title: Secular trends of HPV genotypes in invasive cervical cancer in Cali, Colombia 1950-1999.
abstract: Aim To estimate relative contribution and time trends of HPV types in cervical cancer in Cali, Colombia over a 50 years' period.
  
  
  METHODS
  Paraffin blocks of 736 cervical cancer histological confirmed cases were retrieved from the pathology laboratory at Hospital Universitario del Valle (Cali, Colombia) and HPV genotyped using SPF10-PCR/DEIA/LiPA25 (version 1) assay. Marginal effect of age and year of diagnosis in secular trends of HPV type prevalence among HPV+ cases were assessed by robust Poisson regression analysis.
  
  
  RESULTS
  64.7% (95%CI: 59.9-69.2) of squamous cell carcinomas (SCCs) were attributed to HPV 16 and 18, 78.2% (95%CI: 74-82) to HPV 16, 18, 31, 33 and 45 and 84.8% (95%CI: 81-88.1) to HPV 16, 18, 31, 33, 45, 52 and 58 while ninety-three percent of adenocarcinomas (ADCs) were attributed to HPV 16, 18 and 45 only. The prevalence of specific HPV types did not change over the 50-year period. A significant downward trend of prevalence ratios of HPV16 (​P=0.017) and α7 but HPV 18 (i.e., HPV 39, 45, 68, 70, ​P=0.024) with increasing age at diagnosis was observed. In contrast, the prevalence ratio to other HPV genotypes of α9 but HPV 16 genotypes (i.e., HPV 31, 33, 35, 52, 58, 67, ​P=0.002) increased with increasing age at diagnosis.
  
  
  CONCLUSIONS
  No changes were observed in the relative contribution of HPV types in cervical cancer in Cali, Colombia during the 50 years. In this population, an HPV vaccine including the HPV 16, 18, 31, 33, 45, 52 and 58 genotypes may have the potential to prevent ∼85% and 93% of SCC and ADC cases respectively.
authors.affiliation: Group Infection and Cancer, School of Medicine and Corporación Académica para el Estudio de Patologías Tropicales, Universidad de Antioquia (UdeA), Medellín, Colombia. Electronic address: gloria.sanchez@udea.edu.co.
authors.forename: Gloria Ines
authors.initials: GI
authors.lastname: Sanchez
authors.affiliation: Registro Poblacional de Cancer de Cali, Universidad del Valle, Cali, Colombia.
authors.forename: Luis Eduardo
authors.initials: LE
authors.lastname: Bravo
authors.affiliation: Grupo Epidemiologia, Instituto Nacional de Cancerologia, Bogotá, Colombia.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Hernandez-Suarez
authors.affiliation: IDIBELL, Institut Català d'Oncologia-Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Tous
authors.affiliation: IDIBELL, Institut Català d'Oncologia-Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
authors.forename: Laia
authors.initials: L
authors.lastname: Alemany
authors.affiliation: IDIBELL, Institut Català d'Oncologia-Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: de Sanjose
authors.affiliation: IDIBELL, Institut Català d'Oncologia-Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: F Xavier
authors.initials: FX
authors.lastname: Bosch
authors.affiliation: Grupo Epidemiologia, Instituto Nacional de Cancerologia, Bogotá, Colombia.
authors.forename: Nubia
authors.initials: N
authors.lastname: Muñoz
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000821:virology; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000821:virology; D003105:Colombia / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology
keywords: Cervical cancer; Colombia; HPV types; HPV vaccines; Time trends