title: [RESEARCH PROGRESS OF MICROENVIRONMENT FOR TREATMENT OF PERIPHERAL NERVOUS INJURIES].
abstract: OBJECTIVE
  To review the research progress of microenvironment for the treatment of peripheral nervous injuries.
  
  
  METHODS
  The recent literature concerning the treatment mechanism of peripheral nervous injuries was extensively consulted, and the microenvironment response involved in the treatment of peripheral nervous injuries was reviewed.
  
  
  RESULTS
  The complex microenvironment for treatment of peripheral nervous injuries is dependent on nerve regeneration chamber, the formation of neurotrophic factors, inflammation response, regulation of hormones, signaling pathways, and related enzymes in regulation. In-depth study will help us have a clearer understanding on the distal and proximal neurons axons at the cellular and molecular levels after peripheral nervous injuries.
  
  
  CONCLUSIONS
  In recent years, the researches of microenvironment for the treatment of peripheral nervous injuries have achieved obvious progress. With the current nanotechnology, materials science, genetic engineering, and stem cell transplantation technology, it will provide new ideas and corresponding basis for clinical treatment.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Yao
authors.forename: Jieyuan
authors.initials: J
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Bingcang
authors.initials: B
authors.lastname: Li
mesh_terms: D001369:Axons; D006801:Humans; D036103:Nanotechnology / Q000639:trends; D009414:Nerve Growth Factors; D009416:Nerve Regeneration; D059348:Peripheral Nerve Injuries / Q000601:surgery*; D010525:Peripheral Nerves / Q000601:surgery*; D015398:Signal Transduction; D033581:Stem Cell Transplantation; D023822:Tissue Engineering / Q000379:methods / Q000639:trends
chemical_list: D009414:Nerve Growth Factors