title: Sesame fractions and lipid profiles: a systematic review and meta-analysis of controlled trials.
abstract: Increased plasma lipid profiles are among the most important risk factors of CHD and stroke. Sesame contains considerable amounts of vitamin E, MUFA, fibre and lignans, which are thought to be associated with its plasma lipid-lowering properties. This study aimed to systematically review the evidence and identify the effects of sesame consumption on blood lipid profiles using a meta-analysis of controlled trials. PubMed, CINAHL and Cochrane Library databases were searched (from 1960 to May 2015). A total of ten controlled trials were identified based on the eligibility criteria. Both the Cochrane Collaboration tool and the Rosendal scale were used to assess the risk of bias of the included studies. The meta-analysis results showed that consumption of sesame did not significantly change the concentrations of total blood cholesterol (-0·32 mmol/l; 95% CI -0·75, 0·11; P=0·14, I(2)=96%), LDL-cholesterol (-0·15 mmol/l; 95% CI -0·50, 0·19; P=0·39, I(2)=96%) or HDL-cholesterol (0·01 mmol/l; 95% CI -0·00, 0·02; P=0·16, I(2)=0%). However, a significant reduction was observed in serum TAG levels (-0·24 mmol/l; 95% CI -0·32, -0·15; P<0·001, I(2)=84%) after consumption of sesame. It was concluded that sesame consumption can significantly reduce blood TAG levels but there is insufficient evidence to support its hypocholesterolaemic effects. Further studies are required to determine the potential effect of sesame consumption on lipid profiles and cardiovascular risk factors.
authors.affiliation: 1Population and Social Health Research Program,School of Medicine,Menzies Health Institute Queensland,Griffith University,Gold Coast,QLD 4222,Australia.
authors.forename: Saman
authors.initials: S
authors.lastname: Khalesi
authors.affiliation: 1Population and Social Health Research Program,School of Medicine,Menzies Health Institute Queensland,Griffith University,Gold Coast,QLD 4222,Australia.
authors.forename: Ernesta
authors.initials: E
authors.lastname: Paukste
authors.affiliation: 2Molecular Basis of Disease Program,School of Medical Science,Menzies Health Institute Queensland,Griffith University,Gold Coast,QLD 4222,Australia.
authors.forename: Elham
authors.initials: E
authors.lastname: Nikbakht
authors.affiliation: 1Population and Social Health Research Program,School of Medicine,Menzies Health Institute Queensland,Griffith University,Gold Coast,QLD 4222,Australia.
authors.forename: Hossein
authors.initials: H
authors.lastname: Khosravi-Boroujeni
mesh_terms: D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D004043:Dietary Fiber / Q000032:analysis; D005229:Fatty Acids, Monounsaturated / Q000032:analysis; D006801:Humans; D017705:Lignans / Q000032:analysis; D016032:Randomized Controlled Trials as Topic; D012680:Sensitivity and Specificity; D031685:Sesamum / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood*; D014810:Vitamin E / Q000032:analysis
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D005229:Fatty Acids, Monounsaturated; D017705:Lignans; D014280:Triglycerides; D014810:Vitamin E
keywords: CHD; Cholesterol; HDL-cholesterol; LDL-cholesterol; Sesame; TAG