title: SYNTHESIS AND BIOLOGICAL EFFICACY OF NOVEL PIPERAZINE ANALOGUES BEARING QUINOLINE AND PYRIDINE MOIETIES.
abstract: A series of novel piperazine analogues bearing quinolin-8-yloxy-butan--ones/pyridin-2-yloxy-ethanones were synthesized by a simple and convenient approach based on various substituted piperazine incorporating quinoline and pyridine moieties. The analogues were evaluated for in vitro antioxidant activity against 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and ferrous ion radical scavenging activities and anti-inflammatory activity by inhibition of Vipera russelli venom (PLA2) and gastric K+/H(+)-ATPase activities. Most of the title compounds exhibited promising activity. Best antioxidant and PLA2-inhibiting activities were found for piperazine analogues with phenyl and nitro phenyl groups, whereas methoxy group on phenyl piperazine indicated selectivity for the H+/K(+)-ATPase.
authors.forename: M
authors.initials: M
authors.lastname: Al-Ghorbani
authors.forename: N D
authors.initials: ND
authors.lastname: Rekha
authors.forename: V Lakshmi
authors.initials: VL
authors.lastname: Ranganatha
authors.forename: V
authors.initials: V
authors.lastname: Prashanth
authors.forename: T
authors.initials: T
authors.lastname: Veerabasappagowda
authors.forename: S A
authors.initials: SA
authors.lastname: Khanum
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D054501:Group II Phospholipases A2 / Q000037:antagonists & inhibitors; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D015394:Molecular Structure; D010295:Parietal Cells, Gastric / Q000187:drug effects / Q000201:enzymology; D010851:Picrates / Q000737:chemistry; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D012756:Sheep
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D005609:Free Radicals; D010851:Picrates; D010879:Piperazines; D011725:Pyridines; D011804:Quinolines; C004931:1,1-diphenyl-2-picrylhydrazyl; C037219:quinoline; D054501:Group II Phospholipases A2; C408444:VRV-PL-VIIIa phospholipase A2, Vipera russelli; D017506:H(+)-K(+)-Exchanging ATPase; C023666:pyridine