title: Effect of Increasing Doses of Linoleic and α-Linolenic Acids on High-Fructose and High-Fat Diet Induced Metabolic Syndrome in Rats.
abstract: Doses and ratio of linoleic acid (LA) and α-linolenic acid (ALA) preventing metabolic syndrome (MS) were investigated. SD rats were fed (i) basal diet, (ii) high-fructose and high-fat diet (HFFD), (iii) HFFD with increasing-dose LA (0.75 energy-% ALA + 3, 6, 9, 12, 15, and 30 energy-% LA), and (iv) HFFD with increasing-dose ALA (6 energy-% LA + 0.3, 0.5, 0.75, 1.5, 2.25, and 3.75 energy-% ALA) for 18 weeks. Results showed 6, 12, 15, and 30 energy-% LA significantly ameliorated central obesity, hyperlipidemia, glucose homeostasis, and leptin status; 0.5 and 0.75 energy-% ALA significantly improved insulin sensitivity, adiponectin, and anti-inflammatory status. Moreover, high intakes of ALA (1.5, 2.25, and 3.75 energy-%) presented a pro-oxidant activity. In conclusion, dose instead of ratio determines the prevention of MS. The optimal doses are 6 energy-% LA and 0.75 energy-% ALA; high intakes of ALA may have side effects.
authors.forename: Jianan
authors.initials: J
authors.lastname: Zhang
authors.forename: Ou
authors.initials: O
authors.lastname: Wang
authors.forename: Yingjian
authors.initials: Y
authors.lastname: Guo
authors.forename: Tuo
authors.initials: T
authors.lastname: Wang
authors.forename: Siyi
authors.initials: S
authors.lastname: Wang
authors.forename: Guopeng
authors.initials: G
authors.lastname: Li
authors.forename: Baoping
authors.initials: B
authors.lastname: Ji
authors.affiliation: Oil Crops Research Institute, Chinese Academy of Agricultural Sciences , Wuhan 430062, People's Republic of China.|Hubei Key Laboratory of Lipid Chemistry and Nutrition , Wuhan 430062, People's Republic of China.
authors.forename: Qianchun
authors.initials: Q
authors.lastname: Deng
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects / Q000032:analysis / Q000378:metabolism; D005632:Fructose / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D017962:alpha-Linolenic Acid / Q000008:administration & dosage*
chemical_list: D004041:Dietary Fats; D017382:Reactive Oxygen Species; D017962:alpha-Linolenic Acid; D005632:Fructose
keywords: dose; linoleic acid; metabolic syndrome; ratio; α-linolenic acid