title: [PULMONARY AND INTESTINAL TUBERCULOSIS DEVELOPING ACUTE TUBERCULOUS PERFORATION OF THE INTESTINE DURING ANTITUBERCULOSIS THERAPY].
abstract: Intestinal tuberculosis (TB) was recognized as the most common complication with a high frequency of active pulmonary TB during the TB epidemic period. However, intestinal TB has become a rare disease, and intestinal perforation due to intestinal TB is extremely rare. We herein report two cases of tuberculous intestinal perforation.
  
  
  METHODS
  A 41-year-old man was admitted to our hospital complaining of persistent cough and anorexia. He was in poor nutritional condition, and his body mass index (BMI) and prognostic nutrition index (PNI) were 13.4 and 36.4, respectively. He was diagnosed with pulmonary TB and received anti-TB therapy. On the 51st day of hospitalization, he developed intestinal perforation. Pathologically caseating epithelioid granulomas were noted at the ulcer lesion.
  
  
  METHODS
  A 61-year-old man was admitted to our hospital due to miliary TB caused by intestinal TB. He had taken oral immunosuppressive drugs and steroids for dermatomyositis over the previous eight years and had a poor nutritional condition, with a BMI of 13.4 and a PNI of 14.4. While receiving anti-TB therapy, he developed intestinal perforation on the 97th day of hospitalization. The patient's poor nutritional condition and immune reconstitution may have contributed to the intestinal perforation.
authors.forename: Miwako
authors.initials: M
authors.lastname: Saitou
authors.forename: Tomoko
authors.initials: T
authors.lastname: Suzuki
authors.forename: Katsunao
authors.initials: K
authors.lastname: Niitsuma
mesh_terms: D000208:Acute Disease; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014385:Tuberculosis, Gastrointestinal / Q000150:complications* / Q000188:drug therapy*; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents