title: Cyclodextrin induced controlled delivery of a biological photosensitizer from a nanocarrier to DNA.
abstract: In this article, we have addressed to a demanding physicochemical aspect of therapeutic and drug research. We have reported a simple yet prospective technique that can be exploited for the controlled delivery of drugs and/or bioactive small molecules to the most relevant biomolecular target DNA. Exploiting various steady state and time resolved spectroscopic techniques together with the DNA helix melting study, we have shown that a biologically significant photosensitizer, namely, phenosafranin (PSF), can be quantitatively transferred to the DNA from the micellar nanocarrier made up of sodium tetradecyl sulfate (STS) using the external stimulant β-cyclodextrin (β-CD). The complexation property of β-CD with the nanocarrier (STS) has been utilized for the controlled release of the probe from the micelle to the DNA. Non-toxicity of the stimulant and the noninvasive nature of the carrier towards the target are expected to add to the suitability of this approach from a clinical perspective.
authors.affiliation: Department of Chemistry, Jadavpur University, Kolkata-700032, India. ghosh.saptarshi89@gmail.com nitin.chattopadhyay@yahoo.com.
authors.forename: Pronab
authors.initials: P
authors.lastname: Kundu
authors.affiliation: Department of Chemistry, Jadavpur University, Kolkata-700032, India. ghosh.saptarshi89@gmail.com nitin.chattopadhyay@yahoo.com.
authors.forename: Saptarshi
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Chemistry, Jadavpur University, Kolkata-700032, India. ghosh.saptarshi89@gmail.com nitin.chattopadhyay@yahoo.com.
authors.forename: Sinjan
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Chemistry, Jadavpur University, Kolkata-700032, India. ghosh.saptarshi89@gmail.com nitin.chattopadhyay@yahoo.com.
authors.forename: Nitin
authors.initials: N
authors.lastname: Chattopadhyay
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D008823:Micelles; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D010619:Phenazines / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000737:chemistry*; D012981:Sodium Tetradecyl Sulfate / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D008823:Micelles; D010619:Phenazines; D017319:Photosensitizing Agents; D047392:beta-Cyclodextrins; C011977:phenosafranine; D004247:DNA; C427203:calf thymus DNA; C031215:betadex; D012981:Sodium Tetradecyl Sulfate