title: [Preparation of Oenothera biennis Oil Solid Lipid Nanoparticles Based on Microemulsion Technique].
abstract: OBJECTIVE
  To study the preparation of Oenothera biennis oil solid lipid nanoparticles and its quality evaluation.
  
  
  METHODS
  The solid lipid nanoparticles were prepared by microemulsion technique. The optimum condition was performed based on the orthogonal design to examine the entrapment efficiency, the mean diameter of the particles and so on.
  
  
  RESULTS
  The optimal preparation of Oenothera biennis oil solid lipid nanoparticles was as follows: Oenothera biennis dosage 300 mg, glycerol monostearate-Oenothera biennis (2: 3), Oenothera biennis -RH/40/PEG-400 (1: 2), RH-40/PEG-400 (1: 2). The resulting nanoparticles average encapsulation efficiency was (89.89 ± 0.71)%, the average particle size was 44.43 ± 0.08 nm, and the Zeta potential was 64.72 ± 1.24 mV.
  
  
  CONCLUSIONS
  The preparation process is simple, stable and feasible.
authors.forename: Lin-mei
authors.initials: LM
authors.lastname: Piao
authors.forename: Yong
authors.initials: Y
authors.lastname: Jin
authors.forename: Yan-lin
authors.initials: YL
authors.lastname: Cui
authors.forename: Shou-yu
authors.initials: SY
authors.lastname: Yin
mesh_terms: D004337:Drug Carriers; D008041:Linoleic Acids / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles; D031665:Oenothera biennis / Q000737:chemistry*; D010316:Particle Size; D010938:Plant Oils / Q000737:chemistry; D011092:Polyethylene Glycols; D017965:gamma-Linolenic Acid / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D008041:Linoleic Acids; D008055:Lipids; D010938:Plant Oils; C028498:evening primrose oil; D011092:Polyethylene Glycols; D017965:gamma-Linolenic Acid; C000595213:polyethylene glycol 400