title: Open-Label Study of the Influence of Food Containing the Royal Sun Mushroom, Agaricus brasiliensis KA21 (Higher Basidiomycetes), on the Quality of Life of Healthy Human Volunteers.
abstract: We conducted an open-label study in which food containing Agaricus brasiliensis KA21 was consumed continuously for 12 weeks. A questionnaire for subjective evaluation of the efficacy of this food (hereafter, subjective evaluation questionnaire) revealed significant improvements compared with before its intake; there were improvements in the scores of the amounts of hair loss and gray hair, fatigue and general malaise, eye strain, shoulder stiffness, coldness of extremities, difficulty staying awake during the day, and ease of getting out of bed. These findings suggest that intake of food containing A. brasiliensis KA21 results in the above-mentioned subjectively evaluated improvements, and the possibility that A. brasiliensis KA21 improves the body's immunity. Moreover, no issues regarding the safety of the test food were found.
authors.affiliation: Toei Pharmaceutical Co. Ltd., 2-5-3 Iguchi, Mitaka, Tokyo 181-0011; Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Masuro
authors.initials: M
authors.lastname: Motoi
authors.affiliation: Toei Shinyaku Co., Ltd, Mitaka, Tokyo, Japan.
authors.forename: Akitomo
authors.initials: A
authors.lastname: Motoi
authors.affiliation: Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamanaka
authors.affiliation: Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Sciences School of Pharmacy, Hachioji, Tokyo, Japan.
authors.forename: Naohito
authors.initials: N
authors.lastname: Ohno
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000364:Agaricus; D004032:Diet; D005123:Eye; D005221:Fatigue / Q000178:diet therapy; D005260:Female; D006197:Hair; D064368:Healthy Volunteers; D006801:Humans; D007109:Immunity; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D016059:Range of Motion, Articular; D057566:Self Report; D012782:Shoulder; D012890:Sleep; D011795:Surveys and Questionnaires; D014675:Vegetables