title: Effects of Dexmedetomidine Infusion on the Recovery Profiles of Patients Undergoing Transurethral Resection.
abstract: Transurethral resection has been the gold standard in the operative management of benign prostatic hyperplasia and bladder tumor; however, it is associated with several complications that may cause patient discomfort. We evaluated the usefulness of continuous infusion of dexmedetomidine on emergence agitation, hemodynamic status, and recovery profiles in patients undergoing elective surgery by a randomized clinical trial. Sixty patients aged 30 to 80 yr who were scheduled for elective transurethral resection under general anesthesia were included in this study. Participants were randomly assigned to two groups (control group, group C; dexmedetomidine group, group D). A total of 60 male patients were enrolled in this study and randomly assigned to group C (n=30) or group D (n=30). The quality of emergence in group D was marked by a significantly lower incidence of emergence agitation than in group C (P=0.015). Patients in group D therefore felt less discomfort induced by the indwelling Foley catheter than those in group C (P=0.022). No statistically significant differences were found between the two groups with respect to side effects including bradycardia (P=0.085), hypotension (P=0.640), and postoperative nausea and vomiting (P=0.389). Our study showed that intraoperative dexmedetomidine infusion effectively reduced the incidence and intensity of emergence agitation and catheter-induced bladder discomfort without delaying recovery time and discharge time, thus providing smooth emergence during the recovery period in patients undergoing transurethral resection (Clinical Trial Registry No. KT0001683).
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: So-Young
authors.identifier: 0000-0003-0249-4190
authors.initials: SY
authors.lastname: Kwon
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jin-Deok
authors.identifier: 0000-0002-4365-7091
authors.initials: JD
authors.lastname: Joo
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ga-Young
authors.identifier: 0000-0002-2985-3897
authors.initials: GY
authors.lastname: Cheon
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hyun-Seok
authors.identifier: 0000-0002-1043-7180
authors.initials: HS
authors.lastname: Oh
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jang-Hyeok
authors.identifier: 0000-0001-6206-0103
authors.initials: JH
authors.lastname: In
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D001919:Bradycardia / Q000209:etiology; D020927:Dexmedetomidine / Q000009:adverse effects / Q000627:therapeutic use*; D006439:Hemodynamics; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000627:therapeutic use*; D007022:Hypotension / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D011470:Prostatic Hyperplasia / Q000601:surgery*; D011595:Psychomotor Agitation / Q000188:drug therapy*; D020728:Transurethral Resection of Prostate; D014839:Vomiting / Q000209:etiology
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine
keywords: Anesthesia Recovery Period; Dexmedetomidine; Postoperative Nausea and Vomiting; Transurethral Resection