title: Role of Embryo Glue as a transfer medium in the outcome of fresh non-donor in-vitro fertilization cycles.
abstract: BACKGROUND
  EmbryoGlue is a hyaluronan-enriched embryo transfer (ET) medium which aids in implantation of embryos, hence, improves pregnancy rates in in-vitro fertilization-ET cycles (IVF-ET).
  
  
  OBJECTIVE
  To evaluate the role of EmbryoGlue in improving implantation and pregnancy rates.
  
  
  METHODS
  A prospective case-control study conducted at assisted reproductive center of a tertiary care hospital.
  
  
  METHODS
  In 42 women undergoing IVF, embryos were transferred into 50 μL of EmbryoGlue for 10 min prior to transfer inside uterine cavity. In the control group (n = 42), embryos were transferred to conventional blastocyst culture medium. Statistical analysis was performed using SPSS IBM version 19.0.
  
  
  RESULTS
  Clinical pregnancy rate in the study group was 7% higher than the control group. The difference, however, was not statistically significant. In addition, no improvement in implantation rates was observed in the study group. However, significant difference (P = 0.04) in clinical pregnancy rate was observed with the EmbryoGlue in patients with previous IVF failure. In the study group, 50% patients (6/12) with previous IVF failure had successful implantation, but in the control group none of the patients (0/11) with previous implantation failure could achieve pregnancy.
  
  
  CONCLUSIONS
  It is difficult to conclude a favourable role of EmbryoGlue in IVF-ET cycles with a good prognosis. However, in patients with recurrent implantation failure, it may be considered as a useful transfer medium.
authors.affiliation: Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India.
authors.forename: Neeta
authors.initials: N
authors.lastname: Singh
authors.affiliation: Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India.
authors.forename: Monica
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India.
authors.forename: Alka
authors.initials: A
authors.lastname: Kriplani
authors.affiliation: Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India.
authors.forename: Perumal
authors.initials: P
authors.lastname: Vanamail
keywords: Embryo transfer; hyaluronan; implantation; in-vitro fertilization; pregnancy; recurrent implantation failure