title: Characteristics and prognostic factors of synchronous multiple primary esophageal carcinoma: A report of 52 cases.
abstract: BACKGROUND
  To retrospectively analyze the clinical characteristics and prognostic factors of 52 cases of synchronous multiple primary esophageal carcinoma (SMPEC), in order to provide a reference for treatment strategy.
  
  
  METHODS
  Clinical and survival data of 52 patients with SMPEC were analyzed retrospectively. The rates of overall survival (OS), depending on the different factors, were calculated using Kaplan-Meier analysis. A log-rank test was used for univariate survival analysis and Cox's proportional hazards regression model was used for multivariate survival analysis.
  
  
  RESULTS
  Clinical and survival data of 52 patients with SMPEC, hospitalized from 1 January 2003 to 31 October 2011, were analyzed. Twelve patients underwent surgical resection, five received adjuvant radiotherapy and one received adjuvant radiochemotherapy. Thirty-seven of the 40 non-operative patients received external beam radiation therapy and 20 of them received platinum-based chemotherapy. Another three non-operative patients were given platinum-based chemotherapy alone. The one, three, and five-year OS and the median survival time (MST) were 65.4%, 17.3%, 7.7%, respectively, and 15.0 months for the whole cohort. Tumor length and M stage were independent prognostic factors for the whole cohort by multivariate survival analysis (P = 0.010 and 0.047, respectively). For the radiotherapy subgroup, multivariate analysis of prognostic factors identified that shorter tumor length, M0 stage, and chemotherapy were the predominant independent predictors of long-term survival (P = 0.039, 0.022 and 0.010, respectively).
  
  
  CONCLUSIONS
  SMPEC is a relatively rare and aggressive tumor. Combined radiotherapy with chemotherapy seemed to bring a survival benefit and may be a better management choice for unresectable and non-operative SMPEC.
authors.affiliation: Department of Radiation Oncology, Tumor Hospital of Shantou University Medical College Shantou, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Tumor Hospital of Shantou University Medical College Shantou, China.
authors.forename: Zhi-Xiong
authors.initials: ZX
authors.lastname: Lin
keywords: Esophageal neoplasm; multiple primary carcinoma; prognosis