title: [Rapid screening and confirmation of illegally added anti- impotence preparations in health care products by high performance liquid chromatography-high resolution mass spectrometry].
abstract: A method was established for rapid screening and quantifying 11 illegally added anti-impotence preparations (yohimbine, acetildenafil, nor-acetildenafil, homosildenafil, hydroxy-homosildenafil, sildenafil, vardenafil, thioaildenafil, tadalafil, pseudovardenafil, dapoxetine) in health care products by high performance liquid chromatography-high resolution mass spectrometry. The samples were extracted with methanol and analyzed by positive mode in the MS detection. The results showed that the limits of detection were 25.0 ng/mLexcept for nor-acetildenafil (5.0 ng/mL), the linear ranges were 5.0-200.0 ng/mL except for nor-acetildenafil (25.0-500.0 ng/mL) with the correlation coefficients not less than 0.999 0. The recoveries were in the range of 82.0%-105.9% with the relative standard deviations of 4.7%-16.5%. This method is accurate, simple and rapid, and can be used in rapid screening and quantitative analysis of the 11 illegally added anti-impotence in health care products.
authors.forename: Tingting
authors.initials: T
authors.lastname: Hu
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Qu
authors.forename: Mingqin
authors.initials: M
authors.lastname: Kang
authors.forename: Qinglian
authors.initials: Q
authors.lastname: Song
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Zhao
authors.forename: Daihui
authors.initials: D
authors.lastname: Zhang
mesh_terms: D001596:Benzylamines / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D007172:Erectile Dysfunction; D006801:Humans; D026121:Indole Alkaloids / Q000032:analysis; D008297:Male; D013058:Mass Spectrometry; D009281:Naphthalenes / Q000032:analysis; D000068677:Sildenafil Citrate / Q000032:analysis; D000068581:Tadalafil / Q000032:analysis; D000069058:Vardenafil Dihydrochloride / Q000032:analysis; D014665:Vasodilator Agents / Q000032:analysis*
chemical_list: D001596:Benzylamines; D026121:Indole Alkaloids; D009281:Naphthalenes; D014665:Vasodilator Agents; C000602209:yohimbane; D000069058:Vardenafil Dihydrochloride; D000068581:Tadalafil; D000068677:Sildenafil Citrate; C080598:dapoxetine