title: Association between three interleukin-10 gene polymorphisms and coronary artery disease risk: a meta-analysis.
abstract: BACKGROUND
  Previous studies have investigated the associations between interleukin-10 (IL-10) gene polymorphisms (-592C/A, -819C/T and -1082G/A) and risk of coronary artery disease (CAD). However, the results were inconsistent. The aim of this study was to clarify the relationship between IL-10 polymorphisms and CAD risk by a meta-analysis approach.
  
  
  METHODS
  The PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang databases were searched according to predefined criteria for all relevant studies published before June 1, 2015. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were computed to assess the association.
  
  
  RESULTS
  24 eligible studies were enrolled including 9736 CAD patients and 8606 controls. We observed a significant decreased risk of CAD for IL-10 -819C/T polymorphism (T allele vs. C allele:OR = 0.91, 95% CI = 0.84-0.99; TT vs. CT + CC:OR = 0.82, 95% CI = 0.69-0.98), especially in Asians (T allele vs. C allele:OR = 0.76, 95% CI = 0.60-0.96; TT vs. CC:OR = 0.51, 95% CI = 0.27-0.96; TT vs. CT + CC:OR = 0.62, 95% CI = 0.44-0.88). Moreover, we found IL-10 -1082G/A polymorphism might contribute to an increased CAD risk in Asians (AA vs. GG:OR = 1.89, 95% CI = 1.36-2.64; AA vs. AG + GG:OR = 1.39, 95% CI = 1.14-1.68) but not in other ethnic groups. However, no significant association between the IL-10 -592C/A polymorphism and CAD risk was observed.
  
  
  CONCLUSIONS
  Our results indicated that IL-10 -819C/T and IL-10 -1082G/A polymorphisms significantly and race-specifically correlate with CAD risk.
authors.affiliation: Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical UniversityHuai'an, China; Department of Cardiology, Drum Tower Clinical Medical Hospital, Nanjing Medical UniversityNanjing, China.
authors.forename: Bing-Jian
authors.initials: BJ
authors.lastname: Wang
authors.affiliation: Department of Biochip Laboratory, Yantai Yuhuangding Hospital of Qingdao University Yantai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University Huai'an, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Geng
authors.affiliation: Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University Huai'an, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University Huai'an, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Hu
authors.affiliation: Department of Cardiology, Drum Tower Clinical Medical Hospital, Nanjing Medical University Nanjing, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Xu
keywords: Interleukin-10 gene; coronary artery disease; meta-analysis; polymorphisms