title: Clinical predictor and circulating microRNA profile expression in patients with early onset post-stroke depression.
abstract: OBJECTIVE
  We aim to explore the clinical factors and blood biomarker for predicting the early-onset post-stroke depression (PSD).
  
  
  METHODS
  251 acute ischemic stroke patients were divided into PSD group and non-PSD group by Hamilton depression scale in 2 weeks after stroke. The clinical data, the severity, etiology and location of stroke were recorded. The analysis of inflammatory mediator, glycose and lipid metabolism was performed on the day of admission. The association between clinical factors and early onset PSD was studied by logistic regression analysis. In addition, the differentially expressed miRNAs in plasma between the two groups were screened by gene chip and the bio-information was further investigated by GO and KEEG analysis.
  
  
  RESULTS
  Among 251 patients, 45 (17.93%) were diagnosed as early onset PSD. NIHSS score (>3) and carotid stenosis were independent relative factors with early-onset PSD (OR 3.479 and 2.617, p=0.000 and 0.009, respectively). Moreover, lower LDL trended toward association with early onset PSD in minor stroke subgroup (p=0.084). MiRNA profile demonstrated 25 differential expressed circulating miRNAs with FC≥2 and P≤0.05 between the two groups. The target genes of these miRNAs were enriched in pathways of cancer and MAPK signaling.
  
  
  CONCLUSIONS
  The sample of the study was small. The results should be further confirmed in large cohort patients.
  
  
  CONCLUSIONS
  Early onset PSD was more likely in patients with severe neurological deficits and carotid artery stenosis, also note the possible association between lower LDL and depression in minor stroke. Blood miRNAs may be served as a potential biomarker for PSD diagnosis.
authors.affiliation: Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Guo-Yuan
authors.initials: GY
authors.lastname: Yang
authors.affiliation: Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China. Electronic address: liujr300@medmail.com.cn.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China. Electronic address: llzeng@126.com.
authors.forename: Lili
authors.initials: L
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003863:Depression / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D020521:Stroke / Q000097:blood / Q000150:complications* / Q000523:psychology; D013997:Time Factors
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Biomarker; Early onset; LDL; MicroRNA; Post-stroke depression