title: Immunopathogenesis of psoriasis: a possible role of TGFbeta/Smads pathway.
abstract: Psoriasis is a chronic immune-mediated inflammatory skin disease with both genetic and environmental factors contributing to its pathogenesis. Transforming Growth Factor beta (TGFbeta) is a member of a large family of pleiotropic cytokines with three different isoforms (TGFbeta1,2,3). Smads are a family of eight-related proteins that function as intracellular signaling intermediates for TGFbeta once the latter is bound to its receptors (TGFbRI, II and III). The involvement of Smads in TGFbeta signaling has been studied intensively in the skin in the process of wound healing. Few studies, and with controversial results, have investigated at the immunohistochemical and molecular level the role of TGFbeta/Smads signaling in psoriasis.
authors.forename: Roberta
authors.initials: R
authors.lastname: Sferra
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Fargnoli
authors.forename: Eleonora
authors.initials: E
authors.lastname: Corbelli
authors.forename: Cristina
authors.initials: C
authors.lastname: Pellegrini
authors.forename: Ketty
authors.initials: K
authors.lastname: Peris
authors.forename: Eugenio
authors.initials: E
authors.lastname: Gaudio
authors.forename: Antonella
authors.initials: A
authors.lastname: Vetuschi
mesh_terms: D006801:Humans; D011565:Psoriasis / Q000209:etiology* / Q000276:immunology; D051785:Smad Proteins / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology*
chemical_list: D051785:Smad Proteins; D016212:Transforming Growth Factor beta