title: Base-Promoted Formal [4 + 3] Annulation between 2-Fluorophenylacetylenes and Ketones: A Route to Benzoxepines.
abstract: The first base-promoted formal [4 + 3] annulation between 2-fluorophenylacetylenes and ketones has been disclosed. The reaction proceeds through a tandem α-vinylation of ketones followed by an intramolecular nucleophilic aromatic substitution (SNAr) reaction of the in situ generated β,γ-unsaturated ketone intermediates, providing a straightforward access to a wide range of functionalized benzoxepines in moderate to high yields. The transition-metal-free methodology featured a wide substrate scope, the use of easily available starting materials, and a high functional group tolerance.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology , Guangzhou 510640, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Ouyang
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology , Guangzhou 510640, China.
authors.forename: Chaorong
authors.initials: C
authors.lastname: Qi
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology , Guangzhou 510640, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: He
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology , Guangzhou 510640, China.
authors.forename: Youbin
authors.initials: Y
authors.lastname: Peng
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology , Guangzhou 510640, China.
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xiong
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology , Guangzhou 510640, China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Ren
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology , Guangzhou 510640, China.
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang