title: Stabilization of Homeostasis in Rats during Cold Exposure with Ethanol.
abstract: The role of ethanol metabolism system in adaptation of laboratory animals to cold temperatures was shown. Cold stress (1-2°C) modeled in male Wistar rats over 7 weeks significantly modulated endogenous ethanol metabolism and led to reorganization of many physiological systems, which resulted in activation of metabolic processes. Under these conditions, endogenous ethanol was utilized as the most easily and fast metabolized energy substrate, due to which its blood concentration decreased and was replenished at the expense of exogenous ethanol. Normalization of blood ethanol concentration led to better adaptation to cold.
authors.affiliation: Institute of Biological Problems of Cryolithozone, Siberian Division of the Russian Academy of Sciences, Yakutsk, Russia. kolosova.olga8@inbox.ru.
authors.forename: O N
authors.initials: ON
authors.lastname: Kolosova
authors.affiliation: Institute of Biological Problems of Cryolithozone, Siberian Division of the Russian Academy of Sciences, Yakutsk, Russia.
authors.forename: B M
authors.initials: BM
authors.lastname: Kershengolts
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology; D003080:Cold Temperature; D000431:Ethanol / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol
keywords: adaptation; alcohol; cold; ethanol; stress