title: The MTHFR C677T Polymorphism and Risk of Intracerebral Hemorrhage in a Chinese Han Population.
abstract: BACKGROUND
  Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been speculated to be and extensively investigated as a risk factor for various vascular diseases, including intracerebral hemorrhage (ICH). However, results from published studies regarding the role of C677T polymorphism in ICH risk in Chinese populations were contradictory rather than conclusive.
  
  
  METHODS
  In this study, a total of 180 ICH patients and 180 matched controls of Chinese Han ethnicity were enrolled. The MTHFR C677T polymorphism was genotyped by polymerase chain reaction-ligation detection reaction (PCR-LDR). A meta-analysis was conducted by combining our data with previous relevant studies in Chinese populations.
  
  
  RESULTS
  In our case-control study, similar allele frequency (p=0.492) and genotype distribution (p=0.748) of MTHFR C677T polymorphism were detected between ICH patients and controls. Further analysis based on hematoma location did not show a significant association. When combined with previous studies, however, C677T polymorphism was found to be significantly associated with an increased risk for ICH in Chinese populations (recessive model: OR=1.57, 95%CI=1.29-1.91). When focusing on the Han ethnicity, carriers of the TT genotype had an increased risk of ICH (recessive model: OR=1.36, 95%CI=1.05-1.75).
  
  
  CONCLUSIONS
  In this case-control study we did not observe that the MTHFR C677T polymorphism was associated with ICH risk in people of Chinese Han ethnicity. However, when combined with previous published studies, a significant association of C677T polymorphism with an increased risk of ICH was detected in Chinese populations, and also in the subgroup analysis focusing on Han ethnicity.
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Xin
authors.initials: X
authors.lastname: Hu
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Chuanyuan
authors.initials: C
authors.lastname: Tao
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Yunke
authors.initials: Y
authors.lastname: Li
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Sen
authors.initials: S
authors.lastname: Lin
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Chao
authors.initials: C
authors.lastname: You
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000208:ethnology* / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)