title: Protein sequence design and its applications.
abstract: Design of proteins has far-reaching potentials in diverse areas that span repurposing of the protein scaffold for reactions and substrates that they were not naturally meant for, to catching a glimpse of the ephemeral proteins that nature might have sampled during evolution. These non-natural proteins, either in synthesized or virtual form have opened the scope for the design of entities that not only rival their natural counterparts but also offer a chance to visualize the protein space continuum that might help to relate proteins and understand their associations. Here, we review the recent advances in protein engineering and design, in multiple areas, with a view to drawing attention to their future potential.
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Sankaran
authors.initials: S
authors.lastname: Sandhya
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India; IISc Mathematics Initiative, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Richa
authors.initials: R
authors.lastname: Mudgal
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Gayatri
authors.initials: G
authors.lastname: Kumar
authors.affiliation: National Centre for Biological Sciences-TIFR, UAS-GKVK Campus, Bangalore 560065, India.
authors.forename: Ramanathan
authors.initials: R
authors.lastname: Sowdhamini
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India. Electronic address: ns@mbu.iisc.ernet.in.
authors.forename: Narayanaswamy
authors.initials: N
authors.lastname: Srinivasan
mesh_terms: D000595:Amino Acid Sequence; D036103:Nanotechnology; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins