title: D-Pinitol Protects Against Carbon Tetrachloride-Induced Hepatotoxicity in Rats.
abstract: The aim of the study was to evaluate the protective activity of D-Pinitol against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. The animals were divided into six groups, with each group consisting of six animals. Group I animals served as normal controls and received olive oil vehicle (1.0 ml/kg body weight intraperitoneally). Group II rats served as CCl4 controls, which received 30% CCl4 suspended in olive oil (3.0 ml/kg body weight intraperitoneally) twice a week for 4 weeks. Group III rats were treated with 30% CCl4 suspended in olive oil (3.0 ml/kg body weight intraperitoneally) twice a week for 4 weeks, followed by D-Pinitol (100 mg/kg body weight) given for 28 days intragastrically. Group IV rats received D-Pinitol alone at a concentration of 100 mg/kg body weight for 28 days intragastrically. At the end of the experimental period, serum marker enzymes and lipid peroxidation (LPO) levels were significantly increased in group II animals. On the other hand, D-Pinitol treatment significantly decreased marker enzymes and LPO levels and increased the antioxidant level. CYP expression was also investigated. Therefore, the present study revealed that D-Pinitol acts as a protective agent by decreasing metabolic activation of xenobiotics through its antioxidant nature.
authors.affiliation: Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia; Department of Pharmacology and Environmental Toxicology, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences.
authors.forename: Thamaraiselvan
authors.initials: T
authors.lastname: Rengarajan
authors.affiliation: NPO-International Laboratory of Biochemistry, Uchide, Nakagawa-ku, Nagoya, Japan.
authors.forename: Peramaiyan
authors.initials: P
authors.lastname: Rajendran
authors.affiliation: Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia; Department of Microbiology, Immunology and Genetics, Ben Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Nandakumar
authors.affiliation: Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia.
authors.forename: Boobathy
authors.initials: B
authors.lastname: Lokeshkumar
authors.affiliation: Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia.
authors.forename: Maruthaiveeran Periyasamy
authors.initials: MP
authors.lastname: Balasubramanian
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D007294:Inositol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D017207:Rats, Sprague-Dawley; D013025:Glycine max / Q000737:chemistry
chemical_list: D000975:Antioxidants; C021730:pinitol; D007294:Inositol; D002251:Carbon Tetrachloride