title: Influence of Pre-organised Architecture on Cell Adhesion by Using Multivalent RGD Compounds.
abstract: Multimeric RGD-containing compounds were designed to study the influence of ligand architecture on binding avidity. We report the synthesis of a series of tetrameric RGD compounds and their in vitro biological evaluation. The further application of molecular dynamic simulations for structural studies of RGD derivatives reveals that the observed affinities correlate with the accessibility of segregated RGD motif.
authors.affiliation: DCM UMR 5250, Université Grenoble Alpes-CNRS, 570 rue de la Chimie, B. P. 53, 38041, Grenoble cedex 9, France.
authors.forename: Adrien
authors.initials: A
authors.lastname: Grassin
authors.affiliation: DCM UMR 5250, Université Grenoble Alpes-CNRS, 570 rue de la Chimie, B. P. 53, 38041, Grenoble cedex 9, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: Jourdan
authors.affiliation: IBMM UMR 5247, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'École Normale, 34090, Montpellier, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
authors.affiliation: DCM UMR 5250, Université Grenoble Alpes-CNRS, 570 rue de la Chimie, B. P. 53, 38041, Grenoble cedex 9, France. didier.boturyn@ujf-grenoble.fr.
authors.forename: Didier
authors.initials: D
authors.lastname: Boturyn
mesh_terms: D002448:Cell Adhesion; D008024:Ligands; D056004:Molecular Dynamics Simulation; D009842:Oligopeptides / Q000737:chemistry*
chemical_list: D008024:Ligands; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid
keywords: RGD peptide; cell adhesion; ligand design; molecular dynamics; multimeric ligand