title: Long noncoding RNA GAS5 can predict metastasis and poor prognosis: a meta-analysis.
abstract: BACKGROUND
  Growth arrest-specific 5 (GAS5), a newly discovered long-noncoding RNAs (lncRNAs), has been reported to be down-regulated in multiple cancers. This meta-analysis aims to identify the potential value of GAS5 as a biomarker of cancer metastasis and prognosis.
  
  
  METHODS
  We searched the MEDLINE, EMBASE and Cochrane Library databases. This meta-analysis collected all relevant studies and explored the association of lncRNA GAS5 with overall survival (OS), lymphnode metastasis (LNM), and distant metastasis (DM).
  
  
  RESULTS
  Four studies were eligible for analysis, which included 328 patients. Meta-analysis revealed that low levels of GAS5 expression could predict poor OS in multiple cancers (pooled Hazard Ratio [HR]: 0.38, 95% confidence interval [CI]: 0.26-0.54, P<0.00001). Moreover, compared with high GAS5 expression, low GAS5 expression was correlated with LNM (pooled HR: 4.03, 95% CI: 1.93-8.41, P=0.0002) and DM (pooled HR: 10.17, 95% CI: 1.26-82.31, P=0.03).
  
  
  CONCLUSIONS
  lncRNA GAS5 may potentially serve as a novel biomarker for cancer metastasis and prognosis.
authors.affiliation: Department of Hepatobiliary Surgery, The Second affiliated hospital of Nanchang University, Nanchang, China - tofsw@sina.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Song
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Run-Jin
authors.initials: RJ
authors.lastname: Zhang
authors.forename: Qi-Xin
authors.initials: QX
authors.lastname: Dai
authors.forename: Shu-Bin
authors.initials: SB
authors.lastname: Zou
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D015536:Down-Regulation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D053208:Kaplan-Meier Estimate; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; C561567:GAS5 long non-coding RNA, human; D062085:RNA, Long Noncoding