title: A Water-Ethanol Extract from the Willow Bracket Mushroom, Phellinus igniarius (Higher Basidiomycetes), Reduces Transient Cerebral Ischemia-Induced Neuronal Death.
abstract: This study investigated the potential neuroprotective effect of a mushroom extract from Phellinus igniarius (Piwep) after transient cerebral ischemia. Ph. Igniarius, which has a history of traditional medicinal use, contains immunomodulatory compounds that have been described to have effects on the human immune system. Using a model of transient cerebral ischemia induced by both common carotid artery occlusion and hypovolemia, a water-ethanol extract precipitate of Ph. Igniarius (Piwep) was delivered intraperitoneally immediately after the insult and was injected subsequently every other day for the experimental course. Neuronal death was examined by Fluoro-Jade B staining 1 week after the insult. Piwep injection lead to decreased hippocampal neuronal death, suppression of oxidative injury, activation of microglia, and disruption of the blood-brain barrier. We conclude that Piwep potently inhibits hippocampal neuronal death following ischemia and may have a high therapeutic potential for ameliorating stroke-induced neuron death in the clinical setting.
authors.affiliation: Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea.
authors.forename: Bo Young
authors.initials: BY
authors.lastname: Choi
authors.affiliation: Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Physiology, College of Medicine, Hallym University, Chuncheon, Republic of Korea.
authors.forename: In Yeol
authors.initials: IY
authors.lastname: Kim
authors.affiliation: Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea.
authors.forename: Bo Eun
authors.initials: BE
authors.lastname: Lee
authors.affiliation: Department of Nursing, Inha University, Incheon, Republic of Korea.
authors.forename: Min
authors.initials: M
authors.lastname: Sohn
authors.affiliation: MushMed Co., Ltd, Chuncheon, Gangwon-do, Republic of Korea.
authors.forename: Hyoung Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Suh
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001487:Basidiomycota; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology; D017628:Microglia / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D020521:Stroke / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000975:Antioxidants; D001688:Biological Products; D018696:Neuroprotective Agents