title: NFATc1 regulates the transcription of DNA damage-induced apoptosis suppressor.
abstract: DNA damage induced apoptosis suppressor (DDIAS), or human Noxin (hNoxin), is strongly expressed in lung cancers. DDIAS knockdown induced apoptosis in non-small cell lung carcinoma A549 cells in response to DNA damage, indicating DDIAS as a potential therapeutic target in lung cancer. To understand the transcriptional regulation of DDIAS, we determined the transcription start site, promoter region, and transcription factor. We found that DDIAS transcription begins at nucleotide 212 upstream of the DDIAS translation start site. We cloned the DDIAS promoter region and identified NFAT2 as a major transcription factor (Im et al., 2016 [1]). We demonstrated that NFATc1 regulates DDIAS expression in both pancreatic cancer Panc-1 cells and lung cancer cells.
authors.affiliation: Genome Structure Research Center, KRIBB, Daejeon 305-806, Republic of Korea.
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Im
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea.
authors.forename: Kang-Woo
authors.initials: KW
authors.lastname: Lee
authors.affiliation: Genome Structure Research Center, KRIBB, Daejeon 305-806, Republic of Korea; Functional Genomics, Korea University of Science and Technology, Daejeon 305-350, Republic of Korea.
authors.forename: Kyoung-Jae
authors.initials: KJ
authors.lastname: Won
authors.affiliation: Genome Structure Research Center, KRIBB, Daejeon 305-806, Republic of Korea.
authors.forename: Bo-Kyung
authors.initials: BK
authors.lastname: Kim
authors.affiliation: Biomedical Translational Research Center, KRIBB, Daejeon 305-806, Republic of Korea.
authors.forename: Hyun Seung
authors.initials: HS
authors.lastname: Ban
authors.affiliation: Genome Structure Research Center, KRIBB, Daejeon 305-806, Republic of Korea; Functional Genomics, Korea University of Science and Technology, Daejeon 305-350, Republic of Korea.
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Yoon
authors.affiliation: Genome Structure Research Center, KRIBB, Daejeon 305-806, Republic of Korea.
authors.forename: Young-Ju
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Genomics Research Center, KRIBB, Daejeon 305-806, Republic of Korea.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Food Science and Technology, Chungnam National University, Daejon 305-764, Republic of Korea.
authors.forename: Kyung-Bin
authors.initials: KB
authors.lastname: Song
authors.affiliation: Genome Structure Research Center, KRIBB, Daejeon 305-806, Republic of Korea; Functional Genomics, Korea University of Science and Technology, Daejeon 305-350, Republic of Korea.
authors.forename: Misun
authors.initials: M
authors.lastname: Won
keywords: ChIP; DDIAS; Lung cancer; NFATc1; Pancreatic cancer