title: The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population.
abstract: The SNP rs1006737 in CACNA1C gene has been significantly associated with psychiatric disorders (e.g., schizophrenia and bipolar disorder) in European populations. In Han Chinese, rs1006737 is also strongly associated with schizophrenia, although the effects of the psychosis risk SNP on related brain functions and structures in this population remain unclear. Here, we examined the association of rs1006737 with gray matter volume in a sample of 278 healthy Han Chinese. A whole-brain voxel-based morphometry (VBM) analysis revealed a significant association in the region around right superior occipital gyrus (family-wise error corrected, P = 0.023). Our data provides initial evidence for the involvement of this psychosis genetic risk locus in brain structure variations in Chinese population, and calls for further investigations.
authors.affiliation: First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Huang
authors.affiliation: Imaging Center, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Mo
authors.affiliation: Imaging Center, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China.
authors.forename: Xuejin
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Hualin
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, China.
authors.forename: Lichuan
authors.initials: L
authors.lastname: Wu
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D020746:Calcium Channels, L-Type / Q000235:genetics*; D005260:Female; D066128:Gray Matter / Q000033:anatomy & histology*; D006801:Humans; D008297:Male; D009929:Organ Size / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
chemical_list: C079146:CACNA1C protein, human; D020746:Calcium Channels, L-Type
keywords: CACNA1C; Han Chinese; gray matter; rs1006737; voxel-based morphometry