title: Hyperthyroidism Presenting With Pathologic Fractures.
abstract: Previous studies have shown that thyroid hormone directly stimulates bone resorption in in vitro organ culture, and in adults excess thyroid hormone is associated with decreased bone mineral density. There are limited data in children regarding the effect of hyperthyroidism on bone metabolism and even fewer instances in the literature of hyperthyroidism presenting with bone demineralization and fracture. We report a case of an 11-year-old boy with undiagnosed hyperthyroidism presenting with fractures and osteoporosis. This case emphasizes the importance of maintaining a broad differential diagnosis when a patient presents with a pathologic fracture.
authors.affiliation: Department of Pediatrics, sarezkym@email.chop.edu.
authors.forename: Margaret D
authors.initials: MD
authors.lastname: Sarezky
authors.affiliation: Divisions of Emergency Medicine, and.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Corwin
authors.affiliation: Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and.
authors.forename: Victor S
authors.initials: VS
authors.lastname: Harrison
authors.affiliation: Divisions of Emergency Medicine, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Jacobstein
mesh_terms: D002648:Child; D006111:Graves Disease / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000175:diagnosis / Q000209:etiology*; D058866:Osteoporotic Fractures / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D011885:Radius Fractures / Q000000981:diagnostic imaging / Q000209:etiology*; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000209:etiology*; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000293:injuries*