title: The Effect of Intravenous Dexamethasone on Sugammadex Reversal Time in Children Undergoing Adenotonsillectomy.
abstract: BACKGROUND
  Dexamethasone has been shown to cause inhibition of sugammadex reversal in functionally innervated human muscle cells. In this prospective, double-blind, randomized, controlled study, we evaluated the effect of dexamethasone on the reversal time of sugammadex in children undergoing tonsillectomy and/or adenoidectomy.
  
  
  METHODS
  We recruited 60 patients with ASA physical status I to II, between the ages of 3 and 8 years, scheduled for elective tonsillectomy and/or adenoidectomy. After the induction of anesthesia, patients in group D received IV dexamethasone at a dose of 0.5 mg/kg within a total volume of 5 mL saline, whereas patients in group S received only 5 mL IV saline as the control group. At the end of surgery, all patients were given a single bolus dose (2 mg/kg) of sugammadex at reappearance of T2. Demographic data, hemodynamic variables, time to recovery (a train-of-four ratio of 0.9), time to tracheal extubation, and adverse effects were recorded.
  
  
  RESULTS
  There was no statistical significance between 2 groups in time to recovery and time to extubation. Time to recovery was 97.7 ± 23.9 seconds in group D and 91.1 ± 39.5 seconds in group S (P = 0.436; 95% confidence interval, -10.3 to 23.5). Time to extubation was 127.9 ± 23.2 seconds and 123.8 ± 38.7 seconds in group D and in group S, respectively (P = 0.612; 95% confidence interval, -11.9 to 20.05).
  
  
  CONCLUSIONS
  IV dexamethasone, given after induction of anesthesia, at a dose of 0.5 mg/kg, does not substantively affect the reversal time of sugammadex in pediatric patients undergoing adenoidectomy and/or tonsillectomy.
authors.affiliation: From the Department of Anesthesia, Cukurova University Faculty of Medicine, Balcalı Hospital, Adana, Turkey.
authors.forename: Ersel
authors.initials: E
authors.lastname: Gulec
authors.forename: Ebru
authors.initials: E
authors.lastname: Biricik
authors.forename: Mediha
authors.initials: M
authors.lastname: Turktan
authors.forename: Zehra
authors.initials: Z
authors.lastname: Hatipoglu
authors.forename: Hakki
authors.initials: H
authors.lastname: Unlugenc
mesh_terms: D000233:Adenoidectomy / Q000009:adverse effects; D061605:Administration, Intravenous; D000762:Anesthesia Recovery Period; D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis / Q000517:prevention & control; D011446:Prospective Studies; D000077122:Sugammadex; D014068:Tonsillectomy / Q000009:adverse effects; D016896:Treatment Outcome; D047408:gamma-Cyclodextrins / Q000008:administration & dosage*
chemical_list: D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D003907:Dexamethasone