title: Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay.
abstract: During efforts to prepare the known compound , a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.
authors.forename: Victoria J B
authors.initials: VJ
authors.lastname: Gotham
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk.
authors.forename: Melanie C
authors.initials: MC
authors.lastname: Hobbs
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk.
authors.forename: Ryan
authors.initials: R
authors.lastname: Burgin
authors.affiliation: Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.
authors.forename: David
authors.initials: D
authors.lastname: Turton
authors.affiliation: Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.
authors.forename: Carl
authors.initials: C
authors.lastname: Smythe
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk.
authors.forename: Iain
authors.initials: I
authors.lastname: Coldham
mesh_terms: D004305:Dose-Response Relationship, Drug; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D059365:Nonsense Mediated mRNA Decay / Q000187:drug effects*; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D012333:RNA, Messenger; C000611470:VG1 compound