title: Advantage of impulse oscillometry over spirometry to diagnose chronic obstructive pulmonary disease and monitor pulmonary responses to bronchodilators: An observational study.
abstract: OBJECTIVE
  This retrospective study was a comparative analysis of sensitivity of impulse oscillometry and spirometry techniques for use in a mixed chronic obstructive pulmonary disease group for assessing disease severity and inhalation therapy.
  
  
  METHODS
  A total of 30 patients with mild-to-moderate chronic obstructive pulmonary disease were monitored by impulse oscillometry, followed by spirometry. Lung function was measured at baseline after bronchodilation and at follow-up (3-18 months). The impulse oscillometry parameters were resistance in the small and large airways at 5 Hz (R5), resistance in the large airways at 15 Hz (R15), and lung reactance (area under the curve X; AX).
  
  
  RESULTS
  After the bronchodilator therapy, forced expiratory volume in 1 second (FEV1) readings evaluated by spirometry were unaffected at baseline and at follow-up, while impulse oscillometry detected an immediate improvement in lung function, in terms of AX (p = 0.043). All impulse oscillometry parameters significantly improved at follow-up, with a decrease in AX by 37% (p = 0.0008), R5 by 20% (p = 0.0011), and R15 by 12% (p = 0.0097).
  
  
  CONCLUSIONS
  Impulse oscillometry parameters demonstrated greater sensitivity compared with spirometry for monitoring reversibility of airway obstruction and the effect of maintenance therapy. Impulse oscillometry may facilitate early treatment dose optimization and personalized medicine for chronic obstructive pulmonary disease patients.
authors.affiliation: Texas Tech University Health Sciences Center, Lubbock, TX, USA; Amarillo Center for Clinical Research (ACCR), Allergy A.R.T.S. (Asthma, Rheumatology Treatment Specialists), Amarillo, TX, USA.
authors.forename: Constantine
authors.initials: C
authors.lastname: Saadeh
authors.affiliation: Texas Tech University Health Sciences Center, Lubbock, TX, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Saadeh
authors.affiliation: Texas College of Osteopathic Medicine, University of North Texas, Denton, TX, USA.
authors.forename: Blake
authors.initials: B
authors.lastname: Cross
authors.affiliation: Amarillo Center for Clinical Research (ACCR), Allergy A.R.T.S. (Asthma, Rheumatology Treatment Specialists), Amarillo, TX, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Gaylor
authors.affiliation: Amarillo Center for Clinical Research (ACCR), Allergy A.R.T.S. (Asthma, Rheumatology Treatment Specialists), Amarillo, TX, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Griffith
keywords: Bronchodilator; chronic obstructive pulmonary disease; impulse oscillometry; spirometry