title: Intrauterine trophoblast migration: A comparative view of humans and rodents.
abstract: Trophoblast migration and invasion through the decidua and maternal uterine spiral arteries are crucial events in placentation. During this process, invasive trophoblast replace vascular endothelial cells as the uterine arteries are remodeled to form more permissive vessels that facilitate adequate blood flow to the growing fetus. Placentation failures resulting from either extensive or shallow trophoblastic invasion can cause pregnancy complications such as preeclampsia, intrauterine growth restriction, placenta creta, gestational trophoblastic disease and even maternal or fetal death. Consequently, the use of experimental animal models such as rats and mice has led to great progress in recent years with regards to the identification of mechanisms and factors that control trophoblast migration kinetics. This review aims to perform a comparative analysis of placentation and the mechanisms and factors that coordinate intrauterine trophoblast migration in humans, rats and mice under physiological and pathological conditions.
authors.affiliation: a Laboratório de Endocrinologia e Metabolismo, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais , Belo Horizonte , Minas Gerais , Brazil.
authors.forename: Juneo F
authors.initials: JF
authors.lastname: Silva
authors.affiliation: b Laboratório de Patologia, Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais , Belo Horizonte , Minas Gerais , Brazil.
authors.forename: Rogéria
authors.initials: R
authors.lastname: Serakides
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D005260:Female; D006801:Humans; D008954:Models, Biological; D011247:Pregnancy; D012377:Rodentia; D013312:Stress, Physiological; D014327:Trophoblasts / Q000166:cytology*; D014599:Uterus / Q000166:cytology*
keywords: decidua; factors; human; mice; pathology; placentation; rat; trophoblast migration