title: Effect of Ultrafiltration on Pulmonary Function and Interleukins in Patients Undergoing Cardiopulmonary Bypass.
abstract: OBJECTIVE
  To evaluate the effect of ultrafiltration on interleukins, TNF-α levels, and pulmonary function in patients undergoing coronary artery bypass grafting (CABG).
  
  
  METHODS
  Prospective, randomized, controlled trial.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Forty patients undergoing CABG were randomized into a group assigned to receive ultrafiltration (UF) during cardiopulmonary bypass (CPB) or into another group (control) that underwent the same procedure but without ultrafiltration.
  
  
  METHODS
  Interleukins and TNF-α levels, pulmonary gas exchange, and ventilatory mechanics were measured in the preoperative, intraoperative, and postoperative periods. Interleukins and TNF-α also were analyzed in the perfusate of the test group.
  
  
  RESULTS
  There were increases in IL-6 and IL-8 at 30 minutes after CPB and 6, 12, 24, and 36 hours after surgery, along with an increase in TNF-α at 30 minutes after CPB and 24, 36, and 48 hours after surgery in both groups. IL-1 increased at 30 minutes after CPB and 12 hours after surgery, while IL-6 increased 24 and 36 hours after surgery in the UF group. The analysis of the ultrafiltrate showed the presence of TNF-α and traces of IL-1β, IL-6, and IL-8. There were alterations in the oxygen index, alveolar-arterial oxygen difference, deadspace, pulmonary static compliance and airway resistance after anesthesia and sternotomy, as well as in airway resistance at 6 hours after surgery in both groups, with no difference between them.
  
  
  CONCLUSIONS
  Ultrafiltration increased the serum level of IL-1 and IL-6, while it did not interfere with gas exchange and pulmonary mechanics in CABG.
authors.affiliation: Department of Nursing, Federal University of Alfenas, Alfenas;; Department of Surgery, School of Medical Sciences, State University of Campinas (Unicamp), Barão Geraldo, Campinas. Electronic address: ckosour@fcm.unicamp.br.
authors.forename: Carolina
authors.initials: C
authors.lastname: Kosour
authors.affiliation: Department of Surgery, School of Medical Sciences, State University of Campinas (Unicamp), Barão Geraldo, Campinas.
authors.forename: Desanka
authors.initials: D
authors.lastname: Dragosavac
authors.affiliation: Department of Surgery, School of Medical Sciences, State University of Campinas (Unicamp), Barão Geraldo, Campinas.
authors.forename: Nilson
authors.initials: N
authors.lastname: Antunes
authors.affiliation: Pontifical University Catholic of Campinas (PUC-Campinas),Campinas, Brazil.
authors.forename: Rosmari Aparecida Rosa
authors.initials: RA
authors.lastname: Almeida de Oliveira
authors.affiliation: Department of Surgery, School of Medical Sciences, State University of Campinas (Unicamp), Barão Geraldo, Campinas.
authors.forename: Pedro Paulo
authors.initials: PP
authors.lastname: Martins Oliveira
authors.affiliation: Department of Surgery, School of Medical Sciences, State University of Campinas (Unicamp), Barão Geraldo, Campinas.
authors.forename: Reinaldo
authors.initials: R
authors.lastname: Wilson Vieira
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007378:Interleukins / Q000097:blood*; D008168:Lung / Q000503:physiopathology*; D008170:Lung Compliance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D018836:Inflammation Mediators; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D010100:Oxygen
keywords: coronary artery bypass grafts (CABG); inflammatory mediators; interleukins; lung; ultrafiltration