title: Orthodontic tooth movement following analgesic treatment with Aspirin and Algocalmin. An experimental study.
abstract: The objective of this study was the tracing of the effect of Aspirin and Algocalmin, two of the most frequently used analgesics after the application of orthodontic appliances, on the dental displacements, starting from the hypothesis according to whom any substance that inhibits prostaglandins' production will have as result the inhibition of the osteoclasts' activity and of the orthodontic tooth movements implicit. Twenty-four male Wistar rats, separated into three groups were used. Group I (control) included eight rats in which the orthodontic device was applied, without a subsequent administration of any analgesic; Group II - eight rats in which after the device application Aspirin was administrated; and Group III - eight animals in which Algocalmin was administrated. A histological study was completed in order to establish the size of bone areola. Average mesial displacement of the first left inferior maxillary molar 28 days after applying the orthodontic device was of 3.61±0.29 mm for the control group. The average displacement in the group in which Aspirin was administrated was 0.03 mm. In the group treated with Algocalmin, the dental displacement was of 0.19±0.08 mm. Histological examination revealed the presence of large sizes bone areola in control group (244 μm), more reduced in the group treated with Aspirin (74 μm), and intermediate in that treated with Algocalmin (127 μm). Treatments with Aspirin and Algocalmin in experimental groups, immediately after the orthodontic device application, induced a decreased dental displacement rate.
authors.affiliation: Department of Orthodontics, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; cristidolteanu@yahoo.com.
authors.forename: Cristian Doru
authors.initials: CD
authors.lastname: Olteanu
authors.forename: Alin
authors.initials: A
authors.lastname: Şerbănescu
authors.forename: Adina Bianca
authors.initials: AB
authors.lastname: Boşca
authors.forename: Carmen Mihaela
authors.initials: CM
authors.lastname: Mihu
mesh_terms: D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D004177:Dipyrone / Q000494:pharmacology*; D008297:Male; D009967:Orthodontic Appliances; D017208:Rats, Wistar; D014087:Tooth Movement Techniques
chemical_list: D000700:Analgesics; D004177:Dipyrone; D001241:Aspirin