title: Higher level of NT-proCNP in cerebrospinal fluid of patients with meningitis.
abstract: Aminoterminal pro-C type natriuretic peptide (NT-proCNP) as an active form of CNP, has been recently proven to be a potential marker of sepsis and to be linked to inflammatory diseases. So far, there are no studies describing the level of NT-proCNP in meningitis. The purpose of this study was to evaluate the diagnostic value of NT-proCNP in cerebrospinal fluid (CSF) in patients with meningitis and to compare it with the serum level of CRP and procalcitonin (PCT) in this group of patients. The results were compared to serum levels of CRP, PCT and CSF levels of cytosis, protein and lactate. NT-proCNP levels were statistically significant between the control group and the meningitis groups (p=0.02; R=0.3). We also noted a correlation between the level of NT-proCNP in the CSF of all of the study groups (controls and meningitis patients) and the CSF levels of cytosis (p<0.5; R=0.43), protein (p<0.05; R=0.39) and lactate (p<0.05; R=0.34), and also the serum level of CRP (p<0.05; R=0.30), but not serum PCT (p>0.05; R=0.11). These results suggest that NT-proCNP could be a potential marker of meningitis, but it cannot be used to distinguish between the types of meningitis.
authors.affiliation: Department of Laboratory Diagnostics, Mazovian Brodno Hospital in Warsaw, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Tomasiuk
authors.affiliation: Department of Adult's Infectious Diseases, Institute of Infectious and Parasitic Diseases in Warsaw, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Lipowski
authors.affiliation: Department of Neurology, Faculty of Health Science, Medical University of Warsaw, Poland. Electronic address: stanislaw.szlufik@gmail.com.
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Szlufik
authors.affiliation: Department of Neurology, Faculty of Health Science, Medical University of Warsaw, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Peplinska
authors.affiliation: I Department of Anesthesiology and Intensive Care, Medical University of Warsaw, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Mikaszewska-Sokolewicz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D016022:Case-Control Studies; D006801:Humans; D008581:Meningitis / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D020098:Natriuretic Peptide, C-Type / Q000134:cerebrospinal fluid*; D011498:Protein Precursors / Q000097:blood
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; C480579:amino-terminal pro-C-type natriuretic peptide, human; D020098:Natriuretic Peptide, C-Type; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide
keywords: CRP; Cerebrospinal fluid; Meningitis; NT-proCNP; Natriuretic peptide; PCT