title: ISG15 as a novel prognostic biomarker for hepatitis B virus-related hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Interferon-alpha (IFN-α) has recently been recognized to harbor therapeutic potential in prevention and treatment of HCC. IFN-stimulated gene 15 (ISG15) is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. Several studies have shown that the overexpression of ISG15 is correlated with multiply tumor types. However, the role of ISG15 in hepatitis B virus (HBV)-related HCC remains undetermined. ISG15 expression was found to be obviously higher in HBV-related HCC tissues than that in non-tumor tissues. ISG15 is a novel prognostic marker for predicting 5-year overall survival of HBV-related HCC patients. Overexpression of ISG15 was associated with clinicopathological characteristics and poor patient outcomes. ISG15 may serve as a novel prognostic marker for HBV-related HCC. Therefore, ISG15 may represent a novel HCC marker with prognostic significance and may be helpful in selecting patients for and predicting response to the treatment of HBV-related HCC.
authors.affiliation: Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Hunan Province Cancer Hospital and Affiliated Cancer Hospital of Xiangya Medical School, Central South University Changsha, Hunan Province, China.
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Hunan Province Cancer Hospital and Affiliated Cancer Hospital of Xiangya Medical School, Central South University Changsha, Hunan Province, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Hong
authors.affiliation: Department of Molecular Medicine, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University Changsha, Hunan Province, China.
authors.forename: Darong
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Hunan Province Cancer Hospital and Affiliated Cancer Hospital of Xiangya Medical School, Central South UniversityChangsha, Hunan Province, China; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of FloridaGainesville, Florida, USA.
authors.forename: Man
authors.initials: M
authors.lastname: Xia
authors.affiliation: Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Hunan Province Cancer Hospital and Affiliated Cancer Hospital of Xiangya Medical School, Central South UniversityChangsha, Hunan Province, China; Department of Molecular Medicine, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan UniversityChangsha, Hunan Province, China.
authors.forename: Haizhen
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, The second Xiangya Hospital of Central South University Changsha, Hunan Province, China.
authors.forename: Qinglong
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Gastrointestinal Surgery of Second Affiliated Hospital, Cancer Research Institute University of South China Hengyang, Hunan Province, China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Xie
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Gainesville, Florida, USA.
authors.forename: Qunfeng
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Gainesville, Florida, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Hunan Province Cancer Hospital and Affiliated Cancer Hospital of Xiangya Medical School, Central South UniversityChangsha, Hunan Province, China; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of FloridaGainesville, Florida, USA.
authors.forename: Chaohui
authors.initials: C
authors.lastname: Zuo
keywords: HBV; HLCZ01; Hepatocellular carcinoma; ISG15; interferon-alpha; prognostic biomarker