title: Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two U.S. Midwestern communities.
abstract: Hydroxylated polychlorinated biphenyls (OH-PCBs) have been detected in human specimens and some are suspected as being more toxic than their parent compounds. We compared 58 OH-PCB congeners (in 51 chromatographic peaks) in serum samples from participants in the AESOP Study, a longitudinal cohort study of adolescents and their mothers living in urban and rural areas in the United States. We hypothesized that adolescents would have lower levels of OH-PCBs than their mothers and that serum concentration of OH-PCBs would be stable over a 3-year period. We found statistically significant differences in total OH-PCBs between age groups in both East Chicago (p = 0.001) and Columbus Junction (p < 0.001), with adolescents having lower concentrations than their mothers. We observed that lower-chlorinated OH-PCBs were rarely detected, suggesting that they are not retained in serum and/or rapidly biotransformed into other forms. Twelve OH-PCBs, including several that are rarely reported (4,4'-diOH-PCB 202, 4'-OH-PCB 208, and 4-OH-PCB 163) were detected in over 60% of participants. Lastly, from repeated measures within subject serum for three OH-PCBs, concentrations of 4-OH-PCB 107 and 4-OH-PCB 187 changed significantly over three years of the study.
authors.affiliation: Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United States.
authors.forename: Wen Xin
authors.initials: WX
authors.lastname: Koh
authors.affiliation: Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United States; Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, IA 52242, United States. Electronic address: keri-hornbuckle@uiowa.edu.
authors.forename: Keri C
authors.initials: KC
authors.lastname: Hornbuckle
authors.affiliation: Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, IA 52242, United States.
authors.forename: Rachel F
authors.initials: RF
authors.lastname: Marek
authors.affiliation: Department of Biostatistics, The University of Iowa, Iowa City, IA 52242, United States.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United States; Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA 52242, United States. Electronic address: peter-thorne@uiowa.edu.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Thorne
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D007196:Indiana; D007484:Iowa; D008297:Male; D008875:Middle Aged; D009035:Mothers; D011078:Polychlorinated Biphenyls / Q000097:blood*; D012424:Rural Population; D014505:Urban Population
chemical_list: D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls
keywords: Biomonitoring; Hydroxylated PCB; Longitudinal analysis; Metabolism; Polychlorinated biphenyl