title: Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins.
abstract: A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Chi-Jene
authors.initials: CJ
authors.lastname: Chen
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Ermler
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Gene S
authors.initials: GS
authors.lastname: Tan
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA florian.krammer@mssm.edu ronghai@ucr.edu.
authors.forename: Florian
authors.initials: F
authors.lastname: Krammer
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Palese
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA florian.krammer@mssm.edu ronghai@ucr.edu.
authors.forename: Rong
authors.initials: R
authors.lastname: Hai
mesh_terms: D002460:Cell Line; D000939:Epitopes / Q000235:genetics; D015870:Gene Expression; D042822:Genomic Instability; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D009980:Influenza A virus / Q000235:genetics* / Q000254:growth & development / Q000502:physiology; D007252:Influenza Vaccines / Q000235:genetics; D009500:Neutralization Tests; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000235:genetics; D010948:Viral Plaque Assay; D014779:Virus Replication
chemical_list: D000939:Epitopes; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines; D011994:Recombinant Proteins