title: One-Step Synthesis of Sulfonamides from N-Tosylhydrazones.
abstract: The first described reaction between N-tosylhydrazone and SO2 is reported to provide alkyl sulfonamides in the presence of various amines. In this procedurally simple method, hydrazones of both unsaturated aldehydes and ketones proceed in moderate to excellent yields. Primary and secondary aliphatic amines are accommodated in this reaction, which provides a novel route to sulfonamides.
authors.affiliation: Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States.
authors.forename: Andy S
authors.initials: AS
authors.lastname: Tsai
authors.affiliation: Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States.
authors.forename: John M
authors.initials: JM
authors.lastname: Curto
authors.affiliation: Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States.
authors.forename: Benjamin N
authors.initials: BN
authors.lastname: Rocke
authors.affiliation: Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States.
authors.forename: Anne-Marie R
authors.initials: AM
authors.lastname: Dechert-Schmitt
authors.affiliation: Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States.
authors.forename: Gajendrasingh K
authors.initials: GK
authors.lastname: Ingle
authors.affiliation: Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States.
authors.forename: Vincent
authors.initials: V
authors.lastname: Mascitti
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D006835:Hydrazones / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry; D013458:Sulfur Dioxide / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D006835:Hydrazones; D007659:Ketones; D013449:Sulfonamides; D013458:Sulfur Dioxide