title: Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats.
abstract: This study was aimed at the histological investigation of the impact of experimental diabetes on the healthy gingiva of rats. Thirty male Wistar rats were used in this study. The animals were randomly divided into two groups (n= 15) prior to the experiment. Group 1 experimental diabetes was created by streptozotocin injection in 15 rats. Group 2 comprised the control group (15 rats). On the 7th, 14th and 21st days after the induction of diabetes by streptozotocin, five animals from each group were euthanized by cardiac puncture. The gingiva of the maxillary left first molar tooth of the sacrificed animals was extracted for histological examination. Histological examination demonstrated that, when compared to the control group, the diabetes group displayed marked hyperkeratosis and parakeratosis of the gingival epithelium on day 21 post-induction. Furthermore, the diabetes group presented with an increased number of inflammatory cells and vasodilatation of the capillaries, in comparison to the controls. The overall evaluation of the findings obtained in this study suggested that diabetes alone could cause changes in the periodontium and affect periodontal health.
authors.affiliation: Faculty of Dentistry, Dicle University , Diyarbakir , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dağ
authors.affiliation: Faculty of Dentistry, Dicle University , Diyarbakir , Turkey.
authors.forename: Ela
authors.initials: E
authors.lastname: Tules Fırat
authors.affiliation: Diyarbakir Vocational School, Dicle University , Diyarbakir , Turkey.
authors.forename: Ersin
authors.initials: E
authors.lastname: Uysal
authors.affiliation: Faculty of Education, Dicle University , Diyarbakir , Turkey.
authors.forename: Şennur
authors.initials: Ş
authors.lastname: Ketani
authors.affiliation: Faculty of Veterinary Medicine, Dicle University , Diyarbakir , Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Aydın Ketani
keywords: experimental diabetes; gingiva of rats; the histological investigation