title: Cancer Phytotherapy: Recent Views on the Role of Antioxidant and Angiogenesis Activities.
abstract: Nowadays, increases in resistance of tumors to the current therapeutic agents have become a problematic issue. Therefore, efforts to discover new anticancer compounds with high sensitivity of cancer cells are extending. Animal and laboratory researches have shown that exogenous antioxidants are able to help prevent the free radical damage associated with the development of cancer. However, researches in human beings have not demonstrated convincingly that taking antioxidants can reduce the risk of developing cancer. Angiogenesis is also a natural condition that controls the formation of new blood vessels from the available vessels. Today, it is believed that most of the cancers have angiogenesis potential and their growth, metastasis, and invasion depend on angiogenesis. Several compounds with plant origin and with anti-angiogenic properties have been identified. The aim of this study is to review recently published articles about anticancer drugs obtained from plants with antioxidant and anti-angiogenesis properties.
authors.affiliation: 1 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Bahmani
authors.affiliation: 2 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Hedayatollah
authors.initials: H
authors.lastname: Shirzad
authors.affiliation: 3 Virtual School, Department of E-Learning in Medical Education, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Najmeh
authors.initials: N
authors.lastname: Shahinfard
authors.affiliation: 2 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Laaleh
authors.initials: L
authors.lastname: Sheivandi
authors.affiliation: 2 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Rafieian-Kopaei
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008517:Phytotherapy / Q000379:methods*
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D000975:Antioxidants
keywords: angiogenesis; antioxidants; cancer; medicinal plants; tumor