title: IL-21 polymorphisms rs907715 and rs2221903 are associated with decreased non-small cell lung cancer susceptibility.
abstract: The etiology of lung cancer is still incompletely understood. Previous studies have suggested the association between IL-21 polymorphisms and autoimmune diseases, however, little is known about its role in lung cancer susceptibility. Here, we investigated the role of two SNPs of IL-21 gene in a cohort of non-small cell lung cancer (NSCLC) patients. A total of 128 NSCLC patients and 156 healthy controls were genotyped. Multivariate logistic regression was used to analyze the association between IL-21 polymorphisms and NSCLC risk. Our data showed that both rs907715 and rs2221903 were significantly associated with lung cancer susceptibility, and patients carrying rs907715A (P = 0.007, adjusted OR = 0.60, 95% CI = 0.42-0.87) or rs2221903G (P = 0.020, adjusted OR = 0.52, 95% CI = 0.30-0.90) allele had a decreased risk of NSCLC. Further study identified that the association between IL-21 polymorphisms and NSCLC risk was limited to lung adenocarcinoma. Haplotype analysis revealed that the AG (P = 0.006, OR = 0.072 95% CI = 0.011-0.451) and AA (P = 0.022, OR = 0.657, 95% CI = 0.458-0.941) haplotypes of rs907715/rs2221903 were associated with a decreased risk of NSCLC, whereas the GA (P = 0.0001, OR = 1.932, 95% CI = 1.378-2.710) haplotype was associated with an increased risk. In conclusion, our study demonstrates the association between IL-21 polymorphisms (rs907715 and rs2221903) and NSCLC risk in a Chinese Han population, indicating their potential role in lung cancer detection and treatment.
authors.affiliation: Department of Oncology, Shandong UniversityJinan, China; Department of Radiation Oncology, Shandong Cancer Hospital and InstituteJinan, China.
authors.forename: Lanping
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Oncology, Shandong UniversityJinan, China; Department of Radiation Oncology, Shandong Cancer Hospital and InstituteJinan, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Shi
authors.affiliation: Department of Radiology, Shandong Cancer Hospital and Institute Jinan, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Li
authors.affiliation: Internal Medicine-Oncology, Shandong Cancer Hospital and Institute Jinan, China.
authors.forename: Xiuju
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Clinical Lab, Shandong Cancer Hospital and Institute Jinan, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute Jinan, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute Jinan, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Ju
authors.affiliation: Department of Oncology, Shandong UniversityJinan, China; Department of Radiation Oncology, Shandong Cancer Hospital and InstituteJinan, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
keywords: IL-21; NSCLC; SNP; susceptibility