title: Effect of dietary fibers on losartan uptake and transport in Caco-2 cells.
abstract: The objective of this study was to assess the effect of dietary fibers on the transport of losartan, an angiotensin II type 1 receptor blocker, in small intestinal cells. Using Caco-2 cells in vitro, losartan uptake and transport were evaluated in the presence of various fibers (cellulose, chitosan, sodium alginate and glucomannan). Dietary fibers caused a decrease in the uptake of losartan, with chitosan causing a significant reduction. Chitosan and glucomannan significantly reduced the transport of losartan, while cellulose or sodium alginate did not. Dietary fibers also reduced the level of free losartan; however, this did not correlate with the observed reduction in losartan uptake and transport. In summary, chitosan had the greatest inhibitory effect on losartan uptake and transport, and this potential interaction should be considered in patients taking losartan. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Iwazaki
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
authors.forename: Naho
authors.initials: N
authors.lastname: Takahashi
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Miyake
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Hiroshima
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Abe
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
authors.forename: Airi
authors.initials: A
authors.lastname: Yasui
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
authors.forename: Kimie
authors.initials: K
authors.lastname: Imai
mesh_terms: D000464:Alginates / Q000494:pharmacology; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D018938:Caco-2 Cells; D002482:Cellulose / Q000494:pharmacology; D048271:Chitosan / Q000494:pharmacology; D004043:Dietary Fiber / Q000494:pharmacology*; D020723:Glucuronic Acid / Q000494:pharmacology; D006603:Hexuronic Acids / Q000494:pharmacology; D006801:Humans; D019808:Losartan / Q000494:pharmacology*; D008351:Mannans / Q000494:pharmacology
chemical_list: D000464:Alginates; D047228:Angiotensin II Type 1 Receptor Blockers; D004043:Dietary Fiber; D006603:Hexuronic Acids; D008351:Mannans; C022901:(1-6)-alpha-glucomannan; D020723:Glucuronic Acid; D002482:Cellulose; D048271:Chitosan; D019808:Losartan
keywords: chitosan; dietary fiber; interaction; losartan