title: Activation of maternal toll-like receptor-2 causes social deficits and memory impairment in female offspring.
abstract: To study the relevance of the activation of toll-like receptor-2 and abnormal behavioral properties, we introduced prenatal zymosan, a toll-like receptor-2 ligand, to investigate the effect of maternal immunity on offspring behavior. Only female offspring showed impaired social and cognitive function, suggesting that zymosan may influence females' behavior.
authors.affiliation: Departments of aLife and Nanopharmaceutical Sciences bOriental Pharmaceutical Science cKyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul dLaboratory of Neuropharmacology, College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Yeonsu-gu, Incheon, Republic of Korea.
authors.forename: Younghwa
authors.initials: Y
authors.lastname: Lee
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Jeon
authors.forename: Ji Woong
authors.initials: JW
authors.lastname: Choi
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Ryu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000378:metabolism*; D008813:Mice, Inbred ICR; D009483:Neuropsychological Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology*; D021641:Recognition, Psychology / Q000502:physiology; D012727:Sex Characteristics; D012919:Social Behavior; D051195:Toll-Like Receptor 2 / Q000378:metabolism*; D015054:Zymosan
chemical_list: C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2; D015054:Zymosan