title: A leucine zipper pair-based lipid vesicle for image-guided therapy in breast cancer.
abstract: We developed a controllable image-guided therapy system as a powerful tool for diagnostic and therapeutic applications. The system uses a two-step pretargeting approach that takes advantage of the highly selective binding interactions between leucine zipper pairs. It consists of the utilization of a tumor pretargeting probe for diagnosis and, if necessary, a probe for therapy.
authors.affiliation: BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, 305-806, Daejeon, Republic of Korea. jjung@kribb.re.kr.
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Lim
authors.affiliation: BioNano Health Guard Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 305-806, Daejeon, Republic of Korea.
authors.forename: Panki
authors.initials: P
authors.lastname: Bae
authors.affiliation: BioNano Health Guard Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 305-806, Daejeon, Republic of Korea.
authors.forename: Haeran
authors.initials: H
authors.lastname: Kim
authors.affiliation: BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, 305-806, Daejeon, Republic of Korea. jjung@kribb.re.kr and Nanobiotechnology Major, School of Engineering, University of Science and Technology, 125 Gwahangno, Yuseong, Daejeon 305-806, Republic of Korea.
authors.forename: Juyeon
authors.initials: J
authors.lastname: Jung
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D006801:Humans; D016350:Leucine Zippers; D008055:Lipids / Q000737:chemistry*
chemical_list: D008055:Lipids