title: Comparative Biochemical and Motor Function Analysis of Alpha Lipoic Acid and N-Acetyl Cysteine Treatment on Rats with Experimental Spinal Cord Injury.
abstract: OBJECTIVE
  Spinal Cord Injury (SCI) is a devastating health problem both for the patient and the clinician. Numerous treatment modalities have been studied to reverse the effects of spinal cord injury. Herein is reported the effects and the comparison of Alpha Lipoic Acid and N-Acetyl Cysteine on rats with SCI.
  
  
  METHODS
  38 adult male Sprague-Dawley rats were randomly divided into 5 groups: only laminectomy, laminectomy and trauma, laminectomy trauma and Alpha Lipoic Acid 100 mg/kg IP administration, laminectomy trauma and N-Acetyl Cysteine 300 mg/kg IP administration, and vehicle group (PEG). The trauma model was the Modified Allen Weight drop method. After the procedure, the rats' motor function was evaluated using the modified Tarlov Scale and consequently they were sacrificed and the spinal cord tissue was analyzed biochemically for inflammation markers.
  
  
  RESULTS
  Both Alpha Lipoic Acid and N-Acetyl Cysteine administration after the injury significantly improved the results. There was no statistically significant difference in between the agents.
  
  
  CONCLUSIONS
  Although these agents both proven to be effective in ameliorating the effects of SCI, there was not enough evidence in this research to conclude the benefit of one agent over the other.
authors.affiliation: Ankara Ataturk Research and Training Hospital, Department of Neurosurgery, Ankara, Turkey.
authors.forename: Ahmet Gurhan
authors.initials: AG
authors.lastname: Gurcay
authors.forename: Oktay
authors.initials: O
authors.lastname: Gurcan
authors.forename: Atilla
authors.initials: A
authors.lastname: Kazanci
authors.forename: Ismail
authors.initials: I
authors.lastname: Bozkurt
authors.forename: Salim
authors.initials: S
authors.lastname: Senturk
authors.forename: Ebru
authors.initials: E
authors.lastname: Bodur
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Turkoglu
authors.forename: Murad
authors.initials: M
authors.lastname: Bavbek
mesh_terms: D000818:Animals; D003545:Cysteine / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000187:drug effects*; D013119:Spinal Cord Injuries / Q000473:pathology*; D008063:Thioctic Acid / Q000494:pharmacology*
chemical_list: D018696:Neuroprotective Agents; D008063:Thioctic Acid; D003545:Cysteine