title: Ginsenoside Rg1 and 20(S)-Rg3 Induce IgA Production by Mouse B Cells.
abstract: Ginsenosides are the major components of ginseng, which is known to modulate blood pressure, metabolism, and immune function, and has been used to treat various diseases. It has been reported that ginseng and several ginsenosides have immunoregulatory effects on the innate and T cell-mediated immune response. However, their effects on the humoral immune response have not been fully explored. The present study examined the direct effects of red ginseng extract (RGE) and ginsenosides on mouse B cell proliferation and on antibody production and the expression of germline transcripts (GLT) by mouse B cells in vitro. RGE slightly reduced B cell proliferation, but increased IgA production by LPS-stimulated B cells. Furthermore, ginsenoside Rg1 and 20(S)-Rg3 selectively induced IgA production and expression of GLTα transcripts by LPS-stimulated B cells. Collectively, these results suggest that ginsenoside Rg1 and 20(S)-Rg3 can drive the differentiation of B cells into IgA-producing cells through the selective induction of GLTα expression.
authors.affiliation: Department of Microbiology, College of Medicine, Konyang University, Daejeon 35365, Korea.; Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Korea.
authors.forename: Ha-Yan
authors.initials: HY
authors.lastname: Park
authors.affiliation: Department of Microbiology, College of Medicine, Konyang University, Daejeon 35365, Korea.; Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Korea.
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Microbiology, College of Medicine, Konyang University, Daejeon 35365, Korea.; Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Korea.
authors.forename: Kyu-Seon
authors.initials: KS
authors.lastname: Lee
authors.affiliation: Department of Microbiology, College of Medicine, Konyang University, Daejeon 35365, Korea.; Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Korea.
authors.forename: Hee-Kyung
authors.initials: HK
authors.lastname: Yoon
authors.affiliation: Department of Microbiology, College of Medicine, Konyang University, Daejeon 35365, Korea.; Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Korea.
authors.forename: Yung-Choon
authors.initials: YC
authors.lastname: Yoo
authors.affiliation: Department of Microbiology, College of Medicine, Konyang University, Daejeon 35365, Korea.; Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Korea.
authors.forename: Junglim
authors.initials: J
authors.lastname: Lee
authors.affiliation: College of Agriculture and Life Science, Chungnam National University, Daejeon 34134, Korea.
authors.forename: Jae Eul
authors.initials: JE
authors.lastname: Choi
authors.affiliation: Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea.
authors.forename: Pyeung-Hyeun
authors.initials: PH
authors.lastname: Kim
authors.affiliation: Department of Microbiology, College of Medicine, Konyang University, Daejeon 35365, Korea.; Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Korea.
authors.forename: Seok-Rae
authors.initials: SR
authors.lastname: Park
keywords: B cells; Germline α transcripts; Ginseng; Ginsenoside; IgA