title: Association between circulating CD34-positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men.
abstract: BACKGROUND
  Recent studies have confirmed an association between bone metabolism and vascular homeostasis. However, no study has examined the relationship between serum alkaline phosphatase (ALP) (a marker of bone metabolism) and circulating immature cell such as CD34-positive cells (a marker of vascular homeostasis).
  
  
  METHODS
  We conducted a cross-sectional study of this association in 272 elderly Japanese men (60-79 years). Because low body mass index (BMI) status is a known characteristic of Japanese with a high incidence rate of stroke, we used a stratified analysis based on BMI.
  
  
  RESULTS
  Multivariable linear regression analysis adjusted for confounding factors showed a significant correlation between serum ALP and the number of circulating CD34-positive cells, especially for participants with low BMI (<23 kg/m(2)). The parameter estimates (β) and 95% confidence intervals (CI) for one standard deviation increments in serum ALP levels (62 IU/L) for the circulating CD34-positive cell count were β = 0.25 (0.04, 0.45) for total subjects, β = 0.45 (0.16, 0.75) for participants with low BMI (<23 kg/m(2)), and β = 0.04 (-0.25, 0.34) for participants with high BMI (≥23 kg/m(2)).
  
  
  CONCLUSIONS
  Serum ALP correlates positively with circulating CD34-positive cells among a general population of elderly Japanese men, especially those with low BMI (<23 kg/m(2)). These findings suggest that serum ALP levels may constitute an efficient tool for estimating the risk of insufficient vascular homeostasis, especially for participants with relatively few classical cardiovascular risk factors.
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. simizicyuu@yahoo.co.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimizu
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. shimpei.satoh.718@gmail.com.
authors.forename: Shimpei
authors.initials: S
authors.lastname: Sato
authors.affiliation: Department of Island and Community Medicine , Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. jun_koyamatsu@yahoo.co.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Koyamatsu
authors.affiliation: Department of Island and Community Medicine , Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. yhirotomo@yahoo.co.jp.
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Yamanashi
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. nmako@hotmail.com.
authors.forename: Mako
authors.initials: M
authors.lastname: Nagayoshi
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. ko-kado@remus.dti.ne.jp.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kadota
authors.affiliation: Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki, Japan. kazuto@nagasaki-u.ac.jp.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Tsuruda
authors.affiliation: Division of Strategic Collaborative Research Center for Promotion of Collaborative Research on Radiation and Environment Health Effects, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. naomin@nagasaki-u.ac.jp.
authors.forename: Naomi
authors.initials: N
authors.lastname: Hayashida
authors.affiliation: Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. abirun@nagasaki-u.ac.jp.
authors.forename: Norio
authors.initials: N
authors.lastname: Abiru
authors.affiliation: Center for Health and Community Medicine, Nagasaki University, Nagasaki, Japan. hiroymsk@nagasaki-u.ac.jp.
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamasaki
authors.affiliation: Department of Global Health, Medicine and welfare, Atomic bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. takamura@nagasaki-u.ac.jp.
authors.forename: Noboru
authors.initials: N
authors.lastname: Takamura
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. tmaeda@nagasaki-u.ac.jp.|Department of Island and Community Medicine , Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. tmaeda@nagasaki-u.ac.jp.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D018952:Antigens, CD34 / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged
chemical_list: D018952:Antigens, CD34; D000469:Alkaline Phosphatase