title: Stereoselective Synthesis of Diazabicyclic β-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis.
abstract: An efficient C(sp(3))-H bond activation and intramolecular amination reaction via palladium catalysis at the β-position of carboxyamides to make β-lactams was described. The investigation of the substrate scope showed that the current reaction conditions favored activation of the β-methylene group. Short sequences were developed for preparation of various diazabicyclic β-lactam compounds with this method as the key step from chiral proline and piperidine derivatives.
authors.affiliation: Pharmacy College, Chengdu University of Traditional Chinese Medicine , Chengdu 611137, China.|State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, China.
authors.forename: Shi-Jin
authors.initials: SJ
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Wen-Wu
authors.initials: WW
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Cao
authors.affiliation: Pharmacy College, Chengdu University of Traditional Chinese Medicine , Chengdu 611137, China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Dong
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan 430074, China.
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, China.|School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan 430074, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu