title: Mollisolactones A and B, novel dinormonoterpenes from the soft coral Sinularia mollis.
abstract: Two novel dinormonoterpenes, designated as mollisolactones A and B, were discovered from the soft coral Sinularia mollis on the basis of a chromatographic and NMR spectroscopy-based fractionation. Their structures were solved through analysis of comprehensive 1D and 2D NMR spectroscopic data and HRESIMS experiments. The biological activities of the obtained metabolites were evaluated for cytotoxicity against A-459 (human lung carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines as well as antiviral activity against HCMV (human cytomegalovirus).
authors.affiliation: Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
authors.forename: Shi-Yie
authors.initials: SY
authors.lastname: Cheng
authors.affiliation: Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Shang-Kwei
authors.initials: SK
authors.lastname: Wang
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
authors.forename: Yih-Hsin
authors.initials: YH
authors.lastname: Ou
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; Center of Asia-Pacific Marine Researches, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address: yihduh@mail.nsysu.edu.tw.
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000378:metabolism; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003587:Cytomegalovirus / Q000187:drug effects; D019073:HT29 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D039821:Monoterpenes; D012717:Sesquiterpenes; C000611489:mollisolactone A; C000611517:mollisolactone B; C041387:mollislactone
keywords: Antiviral activity; Cytotoxicity; Dinormonoterpenes; HCMV (human cytomegalovirus); Sinularia mollis