title: Anti-phytopathogen, multi-target acetylcholinesterase inhibitory and antioxidant activities of metabolites from endophytic Chaetomium globosum.
abstract: Fourteen metabolites with various structure types were isolated from endophytic Chaetomium globosum. Five compounds were separated from genus Chaetomium for the first time. Some compounds exhibited remarkable inhibition against phytopathogenic fungi causing root rot of Panax notoginseng. Compounds 1-5 had significant DPPH-free radical-scavenging activity. Compounds 3 and 5 indicated significant inhibitions against the acetylcholinesterase (AChE). From preliminary structure-activity relationship, it was found that the oxygenic five-membered ring of 3 and 5 was crucial in the anti-AChE activity. These structures provide new templates for the potential treatment and management of plant diseases and Alzheimer disease.
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.|b School of Pharmaceutical Sciences , Kunming Medical University , Kunming , People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.
authors.forename: Xueqiong
authors.initials: X
authors.lastname: Yang
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.
authors.forename: Yabin
authors.initials: Y
authors.lastname: Yang
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.
authors.forename: Rongting
authors.initials: R
authors.lastname: Duang
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.
authors.forename: Guangyi
authors.initials: G
authors.lastname: Chen
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.
authors.forename: Xiaozhan
authors.initials: X
authors.lastname: Li
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.
authors.forename: Qiling
authors.initials: Q
authors.lastname: Li
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.
authors.forename: Shaohuan
authors.initials: S
authors.lastname: Qin
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.
authors.forename: Shuquan
authors.initials: S
authors.lastname: Li
authors.affiliation: c Yunnan Institute of Microbiology , Yunnan University , Kunming , People's Republic of China.
authors.forename: Lixing
authors.initials: L
authors.lastname: Zhao
authors.affiliation: a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Ding
keywords: Chaetomium globosum; anti-AChE; anti-phytopathogen; antioxidant; metabolite