title: Polyoxometalate-Driven Self-Assembly of Short Peptides into Multivalent Nanofibers with Enhanced Antibacterial Activity.
abstract: Multivalent peptide nanofibers have attracted intense attention as promising platforms, but the fabrication of those nanofibers is mainly dependent on the spontaneous assembly of β-sheet peptides. Herein we report an alternative approach to the creation of nanofibers: the polyoxometalate-driven self-assembly of short peptides. The resultant nanofibers with concentrated positive charges are excellent multivalent ligands for binding with bacterial cells and thus lead to a salient improvement in bioactivity.
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China.
authors.forename: Jingfang
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China.
authors.forename: Mengcheng
authors.initials: M
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China.
authors.forename: Jiangbo
authors.initials: J
authors.lastname: Jing
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China. wenli@jlu.edu.cn.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China.
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Qianjin Avenue 2699, Changchun, 130012, China.
authors.forename: Myongsoo
authors.initials: M
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D046529:Microscopy, Electron, Transmission; D057139:Nanofibers; D010455:Peptides / Q000737:chemistry*; D017973:Tungsten Compounds / Q000737:chemistry*; D000099294:Polyoxometalates
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates
keywords: bioactivity; ionic self-assembly; multivalent nanofibers; polyoxometalates; short peptides