title: Anesthesia and neurotoxicity in the developing brain: A non-systematic review.
abstract: In recent years, increasing experimental evidence has suggested an association between exposure to anesthesia in early life and subsequent poor neurodevelopmental outcome. Retrospective and follow-up studies have also suggested anesthesia-related neurotoxicity in the developing human brain. The present non-systematic review summarizes the available evidence, depicts the current knowledge on the potentially harmful effects of anesthesia and will discuss whether this knowledge urges us to implement changes in clinical practice.
authors.forename: Stefaan
authors.initials: S
authors.lastname: Van Biesen
authors.forename: Marc
authors.initials: M
authors.lastname: Van de Velde
authors.forename: Steffen
authors.initials: S
authors.lastname: Rex
mesh_terms: D000777:Anesthetics / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000209:etiology* / Q000517:prevention & control; D013569:Synapses / Q000187:drug effects / Q000502:physiology
chemical_list: D000777:Anesthetics