title: Targeting the Notch signaling pathway in cancer therapeutics.
abstract: Despite advances in surgery, imaging, chemotherapy, and radiotherapy, the poor overall cancer-related death rate remains unacceptable. Novel therapeutic strategies are desperately needed. Nowadays, targeted therapy has become the most promising therapy and a welcome asset to the cancer therapeutic arena. There is a large body of evidence demonstrating that the Notch signaling pathway is critically involved in the pathobiology of a variety of malignancies. In this review, we provide an overview of emerging data, highlight the mechanism of the Notch signaling pathway in the development of a wide range of cancers, and summarize recent progress in therapeutic targeting of the Notch signaling pathway.
authors.affiliation: Key Laboratory of Longevity and Aging-Related Diseases, Ministry of Education Nanning, China; Center for Translational Medicine, Guangxi Medical University Nanning, China.
authors.forename: Huajiao
authors.initials: H
authors.lastname: Guo
authors.affiliation: Key Laboratory of Longevity and Aging-Related Diseases, Ministry of Education Nanning, China; Center for Translational Medicine, Guangxi Medical University Nanning, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Biochemistry and Molecular & Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis, Ministry of Education Shanghai, China; Institute of Medical Science, Shanghai Jiao Tong University School of Medicine Shanghai, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Longevity and Aging-Related Diseases, Ministry of Education Nanning, China; Center for Translational Medicine, Guangxi Medical University Nanning, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Urology and Pathology, School of Medicine, University of Michigan Ann Arbor, Michigan, USA.
authors.forename: Evan T
authors.initials: ET
authors.lastname: Keller
authors.affiliation: Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital Tianjin, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital Tianjin, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Longevity and Aging-Related Diseases, Ministry of Education Nanning, China; Center for Translational Medicine, Guangxi Medical University Nanning, China; Department of Urology and Pathology, School of Medicine, University of Michigan Ann Arbor, Michigan, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
keywords: Cancer; Notch signaling pathway; oncogene; targeted therapeutics; tumor suppressor gene