title: Neurogenic plasticity of mesenchymal stem cell, an alluring cellular replacement for traumatic brain injury.
abstract: Traumatic brain injury (TBI) imposes horrendous neurophysiological alterations leading to most devastating forms of neuro-disability. Which includes impaired cognition, distorted locomotors activity and psychosomatic disability in both youths and adults. Emerging evidence from recent studies has identified mesenchymal stem cells (MSCs) as one of the promising category of stem cells having excellent neuroregenerative capability in TBI victims. Some of the clinical and animal studies reported that MSCs transplantation could cure neuronal damage as well as improve cognitive and locomotors behaviors in TBI. However, mechanism behind their broad spectrum neuroregenerative potential in TBI has not been reviewed yet. Therefore, in the present article, we present a comprehensive data on the important attributes of MSCs, such as neurotransdifferentiation, neuroprotection, axonal repair and plasticity, maintenance of blood-brain integrity, reduction of reactive oxygen species (ROS) and immunomodulation. We have reviewed in detail the crucial neurogenic capabilities of MSCs in vivo and provided consolidated knowledge regarding their cellular remodeling in TBI for future therapeutic implications.
authors.forename: Soumya
authors.initials: S
authors.lastname: Pati
authors.forename: Sangu
authors.initials: S
authors.lastname: Muthuraju
authors.forename: Raisah Ab
authors.initials: RA
authors.lastname: Hadi
authors.forename: Tee Jong
authors.initials: TJ
authors.lastname: Huat
authors.forename: Shailja
authors.initials: S
authors.lastname: Singh
authors.forename: Mirjana
authors.initials: M
authors.lastname: Maletic-Savatic
authors.affiliation: Center for Neurosciences Services and Research, Universiti Sains Malaysia Hospital, Jalan Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. brainsciences@gmail.com.
authors.forename: Jafri Malin
authors.initials: JM
authors.lastname: Abdullah
authors.forename: Hasnan
authors.initials: H
authors.lastname: Jaafar
mesh_terms: D001369:Axons / Q000473:pathology; D001812:Blood-Brain Barrier / Q000473:pathology; D001921:Brain / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology / Q000628:therapy*; D002454:Cell Differentiation / Q000235:genetics; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells; D009473:Neuronal Plasticity / Q000235:genetics; D009474:Neurons / Q000473:pathology* / Q000637:transplantation