title: Enantioseparation of citalopram analogues with sulfated β-cyclodextrin by capillary electrophoresis.
abstract: Capillary electrophoresis methods were developed for the enantiomeric separation of 27 citalopram analogues. Sulfated β-cyclodextrin was the most broadly selective and useful chiral selector. The separations of most of the citalopram analogue compounds reported in this work have not been reported previously. Excellent enantiomeric separations were obtained for 26 out of 27 compounds, and most of the separations were achieved within 10 min. The effects of chemical parameters such as chiral selector types, buffer types, chiral selector and buffer concentrations, buffer pH and organic modifiers on the separation were investigated. The influence of analyte structure on separation also was examined and discussed.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, USA.
authors.forename: Yadi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, USA.|College of Chemistry & Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China.
authors.forename: Shusheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, USA.
authors.forename: Zachary S
authors.initials: ZS
authors.lastname: Breitbach
authors.affiliation: H. Lundbeck A/S, Chemical Process Research, Valby, Denmark.
authors.forename: Hans
authors.initials: H
authors.lastname: Petersen
authors.affiliation: H. Lundbeck A/S, Chemical Process Research, Valby, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Ellegaard
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, USA.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Armstrong
mesh_terms: D015283:Citalopram / Q000032:analysis* / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D047392:beta-Cyclodextrins; D015283:Citalopram
keywords: Chiral capillary electrophoresis; Citalopram; Enantioseparation; Sulfated β-cyclodextrin