title: Effect of context exposure after fear learning on memory generalization in mice.
abstract: BACKGROUND
  The conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization.
  
  
  RESULTS
  Using a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning.
  
  
  CONCLUSIONS
  Our results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization.
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. s1111651@u.tsukuba.ac.jp.
authors.forename: Ayano
authors.initials: A
authors.lastname: Fujinaka
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. s1411707@u.tsukuba.ac.jp.
authors.forename: Ruoshi
authors.initials: R
authors.lastname: Li
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. genome1214@gmail.com.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Hayashi
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. drkdeependra@gmail.com.
authors.forename: Deependra
authors.initials: D
authors.lastname: Kumar
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. gopkmr.c@gmail.com.
authors.forename: Gopakumar
authors.initials: G
authors.lastname: Changarathil
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. keisukenaito6@gmail.com.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Naito
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. tres.arboles419@gmail.com.
authors.forename: Kousuke
authors.initials: K
authors.lastname: Miki
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. taihei.nishiyama.5320710@gmail.com.
authors.forename: Taihei
authors.initials: T
authors.lastname: Nishiyama
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. lazarus.michael.ka@u.tsukuba.ac.jp.
authors.forename: Michael
authors.initials: M
authors.lastname: Lazarus
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. Takeshi.Sakurai@gmail.com.|Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Ishikawa, Japan. Takeshi.Sakurai@gmail.com.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sakurai
authors.affiliation: University of Toronto, Toronto, Canada. nohjin.kee@alumni.utoronto.ca.
authors.forename: Nohjin
authors.initials: N
authors.lastname: Kee
authors.affiliation: Department of Adult Mental Health, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo, Japan. nakajima@ncnp.go.jp.
authors.forename: Satomi
authors.initials: S
authors.lastname: Nakajima
authors.affiliation: Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. szuhan.wang@gmail.com.
authors.forename: Szu-Han
authors.initials: SH
authors.lastname: Wang
authors.affiliation: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. masanori.sakaguchi@gmail.com.
authors.forename: Masanori
authors.initials: M
authors.lastname: Sakaguchi
mesh_terms: D000818:Animals; D005239:Fear / Q000502:physiology*; D005794:Generalization, Response / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D008810:Mice, Inbred C57BL