title: [Intrinsic factors, genes, and skin aging].
abstract: Skin aging is determined by a combination of endogenous and environmental influences, including epigenetic, posttranslational, microbial, and lifestyle factors. In particular genetic changes, programmed or not, play a pivotal role and understanding of these complex mechanisms may contribute to the prevention of age-related diseases and extension of healthy lifespan. In this article, new knowledge about genes and biological processes that can significantly affect skin homeostasis in old age and can lead to the typical morphological and physiological characteristics of aging skin are summarized.
authors.affiliation: Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Albert-Einstein Allee 23, Life Sciences Building N27, James-Franck Ring/ Meyerhofstr. 11c, 89081, Ulm, Deutschland.|Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06487, Dessau, Deutschland.
authors.forename: E
authors.initials: E
authors.lastname: Makrantonaki
authors.affiliation: Center for Epigenetics, Van Andel Research Institute, 333 Bostwick Avenue NE, 49503, Grand Rapids, MI, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Pfeifer
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06487, Dessau, Deutschland. christos.zouboulis@klinikum-dessau.de.
authors.forename: C C
authors.initials: CC
authors.lastname: Zouboulis
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D044127:Epigenesis, Genetic / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008957:Models, Genetic; D015595:Skin Aging / Q000235:genetics*
keywords: Epigenetics; Gene expression; Genetics; Mutations; Skin homeostasis