title: Palladium-Catalyzed Dehydrative Cross-Coupling of Allylic Alcohols and N-Heterocycles Promoted by a Bicyclic Bridgehead Phosphoramidite Ligand and an Acid Additive.
abstract: A mild and efficient dehydrative cross-coupling reaction between allylic alcohols and N-heterocycles using palladium catalysis is reported. A bicyclic bridgehead phosphoramidite (briphos) ligand together with Pd(dba)2 is a highly efficient catalyst, and an acid additive involved in the rate-determining step promotes the catalytic cycle. The coupling reaction of allylic alcohols with N-heterocycles including imidazoles, benzimidazoles, and triazole proceeds under mild reaction conditions with high yields using Pd/briphos and pentafluorophenol.
authors.affiliation: Department of Chemistry, KAIST , Daejeon 34141, Korea.
authors.forename: Kyungjun
authors.initials: K
authors.lastname: Kang
authors.affiliation: Department of Chemistry, KAIST , Daejeon 34141, Korea.
authors.forename: Jaewook
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Chemistry, KAIST , Daejeon 34141, Korea.
authors.forename: Ansoo
authors.initials: A
authors.lastname: Lee
authors.affiliation: Department of Chemistry, KAIST , Daejeon 34141, Korea.
authors.forename: Woo Youn
authors.initials: WY
authors.lastname: Kim
authors.affiliation: Department of Chemistry, KAIST , Daejeon 34141, Korea.|Center for Nanomaterials and Chemical Reactions, Institute for Basic Science (IBS) , Daejeon 34141, Korea.
authors.forename: Hyunwoo
authors.initials: H
authors.lastname: Kim