title: Nonadherence as 4-day Antiretroviral Therapy Interruptions: Do Depression and Race/Ethnicity Matter as Much in the Modern Antiretroviral Therapy Era?
abstract: HIV + White, Latino, and African Americans (N = 1131) completed a survey advertised on social media to re-examine the effect of depressive symptoms (via the Patient Health Questionnaire; PHQ-9) and race/ethnicity on antiretroviral therapy nonadherence (defined as past 3-month, 4-day treatment interruption). An adjusted logistic regression showed a 15 % increase in odds for a treatment interruption per 1-unit increase on the PHQ-9. The effect of depressive symptoms on nonadherence was greater for Latinos (OR = 1.80, p < 0.05), but not for African Americans, compared to Whites. The benefits of modern ART (e.g., simpler, forgiving to minor lapses) may not circumvent the effect of depressive symptomatology.
authors.affiliation: Center for AIDS Prevention Studies, University of California, San Francisco, 550 16th Street, 3rd Floor, UCSF Mailcode 0886, San Francisco, CA, 94158, USA. john.sauceda@ucsf.edu.
authors.forename: John A
authors.initials: JA
authors.lastname: Sauceda
authors.affiliation: Center for AIDS Prevention Studies, University of California, San Francisco, 550 16th Street, 3rd Floor, UCSF Mailcode 0886, San Francisco, CA, 94158, USA.
authors.forename: Mallory O
authors.initials: MO
authors.lastname: Johnson
authors.affiliation: Center for AIDS Prevention Studies, University of California, San Francisco, 550 16th Street, 3rd Floor, UCSF Mailcode 0886, San Francisco, CA, 94158, USA.
authors.forename: Parya
authors.initials: P
authors.lastname: Saberi
mesh_terms: D000328:Adult; D001741:Black or African American / Q000523:psychology* / Q000706:statistics & numerical data*; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D003866:Depressive Disorder / Q000208:ethnology* / Q000523:psychology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000208:ethnology / Q000523:psychology; D006306:Health Surveys; D006630:Hispanic or Latino / Q000523:psychology* / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000208:ethnology* / Q000523:psychology*; D008875:Middle Aged; D016017:Odds Ratio; D011594:Psychometrics / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires; D014481:United States; D044465:White People / Q000523:psychology* / Q000706:statistics & numerical data*
chemical_list: D019380:Anti-HIV Agents
keywords: Adherence; Antiretroviral therapy; Depression; Latinos; Race/ethnicity