title: Composite Mucoepidermoid Carcinoma and Columnar Cell Variant of Papillary Carcinoma of the Thyroid: A Case Report and Review of the Literature.
abstract: Primary mucoepidermoid carcinoma (MEC) of the thyroid and columnar cell variant of papillary carcinoma of the thyroid (PCT) are uncommon neoplasms. We report the first case of composite MEC and columnar cell variant of PCT. An 86-year-old man consulted for a 47-mm thyroid nodule, cytologically compatible with PCT. Total thyroidectomy was performed. Histological diagnosis, with support of histochemistry and immunohistochemistry, was mixed primary carcinoma of the thyroid, associating an MEC component with predominantly columnar cell variant of PCT. Sixteen months after surgery and external beam radiation therapy, the patient was free of recurrence or distant metastasis. This case report offers an opportunity to highlight the potential pitfalls concerning the interpretation of mucin histochemistry in thyroid tumors.
authors.affiliation: Service de Pathologie Morphologique, Gustave Roussy Cancer Campus, Villejuif, France Universite Paris Nord Sorbonne Cite, UFR Médecine Santé Biologie humaine, Bobigny, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Taconet
authors.affiliation: Service de Pathologie Morphologique, Gustave Roussy Cancer Campus, Villejuif, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Bosq
authors.affiliation: Unité de chirurgie thyroïdienne, Gustave Roussy Cancer Campus, Villejuif, France.
authors.forename: Dana
authors.initials: D
authors.lastname: Hartl
authors.affiliation: Service de médecine nucléaire, Gustave Roussy Cancer Campus, Villejuif, France Université Paris Saclay, Université Paris Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Schlumberger
authors.affiliation: Service de médecine nucléaire, Gustave Roussy Cancer Campus, Villejuif, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Leboulleux
authors.affiliation: Service de Pathologie Morphologique, Gustave Roussy Cancer Campus, Villejuif, France Université Paris Saclay, Université Paris Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Scoazec
authors.affiliation: Service de Pathologie Morphologique, Gustave Roussy Cancer Campus, Villejuif, France abir.alghuzlan@gustaveroussy.fr.
authors.forename: Abir
authors.initials: A
authors.lastname: Al-Ghuzlan
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology*; D018277:Carcinoma, Mucoepidermoid / Q000175:diagnosis / Q000473:pathology*; D002291:Carcinoma, Papillary; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: columnar cell variant of papillary carcinoma; mucoepidermoid carcinoma; thyroid carcinoma