title: A New aDENNDum to Genetics of Childhood Asthma.
abstract: Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a molecular basis for how DENND1B contributes to asthma pathogenesis.
authors.affiliation: VIB Inflammation Research Center (IRC), Gent University, Zwijnaarde 9052B, Belgium; argenx, Technologiepark 30, 9052 Zwijnaarde, Belgium.
authors.forename: Marie
authors.initials: M
authors.lastname: Godar
authors.affiliation: VIB Inflammation Research Center (IRC), Gent University, Zwijnaarde 9052B, Belgium; Department of Respiratory Medicine, Gent University Hospital, Gent 9000, Belgium; Department of Pulmonary Medicine, ErasmusMC, Rotterdam 3015 GE, the Netherlands. Electronic address: bart.lambrecht@ugent.be.
authors.forename: Bart N
authors.initials: BN
authors.lastname: Lambrecht
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D053418:Death Domain Receptor Signaling Adaptor Proteins / Q000378:metabolism*; D005260:Female; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D053418:Death Domain Receptor Signaling Adaptor Proteins; D020662:Guanine Nucleotide Exchange Factors; D011948:Receptors, Antigen, T-Cell