title: Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest.
abstract: Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1-3) and the known sesquiterpenoid cinnamosmolide (4). The structures of 1-3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 2, and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 2.8, 10.2 and 2.0 µM, respectively.
authors.affiliation: Department of Chemistry, Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA, 24061, USA.
authors.forename: Qingxi
authors.initials: Q
authors.lastname: Su
authors.affiliation: Department of Chemistry, Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA, 24061, USA.
authors.forename: Peggy J
authors.initials: PJ
authors.lastname: Brodie
authors.affiliation: Department of Chemistry, Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA, 24061, USA.
authors.forename: Yixi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Missouri Botanical Garden, P.O. Box 299, St. Louis, MO, 63166-0299, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Miller
authors.affiliation: Missouri Botanical Garden, B.P 3391, 101 Antananarivo, Madagascar.
authors.forename: Naina M
authors.initials: NM
authors.lastname: Andrianjafy
authors.affiliation: Centre National d'Application des Recherches Pharmaceutiques, B.P 702, 101 Antananarivo, Madagascar.
authors.forename: Rabodo
authors.initials: R
authors.lastname: Antsiferana
authors.affiliation: Centre National d'Application des Recherches Pharmaceutiques, B.P 702, 101 Antananarivo, Madagascar.
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.affiliation: Department of Chemistry, Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA, 24061, USA. dkingston@vt.edu.
authors.forename: David G I
authors.identifier: http://orcid.org/0000-0001-8944-246X
authors.initials: DG
authors.lastname: Kingston
keywords: Antiproliferative activity; Leptaulus citroides (Cardiopteridacea); Triterpenoid saponins