title: White-matter connectivity related to paliperidone treatment response in patients with schizophrenia.
abstract: The objective of this study was to examine whether white-matter (WM) connectivity of patients with schizophrenia at early stage of treatment is related to treatment response after paliperidone extended-release (ER) treatment. Forty-one patients with schizophrenia and 17 age- and sex-matched healthy control subjects were included in this study. Brain magnetic resonance scans at 3 Tesla were conducted at early stage of treatment. Voxel-wise statistical analysis of the fractional anisotropy (FA) data was performed using Tract-Based Spatial Statistics. At baseline and eight weeks after paliperidone treatment, patients were assessed using the Positive and Negative Syndrome Scale, the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms. Among the patients with schizophrenia, the FA values of the corpus callosum, corona radiata, internal capsule, external capsule, superior longitudinal fasciculus and fronto-temporal WM regions showed significant negative correlations with scores of the treatment response. The current study suggests that the treatment response after paliperidone ER treatment may be associated with the fronto-temporo-limbic WM connectivity at early stage of treatment in patients with schizophrenia, and it could be used as a predictor of treatment response to paliperidone ER treatment after studies with large samples verify these results.
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Min-Kyoung
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Borah
authors.initials: B
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Kang Soo
authors.initials: KS
authors.lastname: Lee
authors.affiliation: Department of Business Administration, Kwangwoon University, Seoul, Republic of Korea.
authors.forename: Chan Mo
authors.initials: CM
authors.lastname: Kim
authors.affiliation: Department of Public Health, Graduate School of Health and Welfare, CHA University, Seongnam, Republic of Korea.
authors.forename: Seong Yun
authors.initials: SY
authors.lastname: Bang
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Tai Kiu
authors.initials: TK
authors.lastname: Choi
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea leesanghyuk@yahoo.com.
authors.forename: Sang-Hyuk
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000328:Adult; D016880:Anisotropy; D003337:Corpus Callosum / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D066271:External Capsule / Q000187:drug effects; D005260:Female; D006801:Humans; D020772:Internal Capsule / Q000187:drug effects; D008297:Male; D009415:Nerve Net / Q000187:drug effects*; D000068882:Paliperidone Palmitate / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*; D054063:Superior Sagittal Sinus / Q000187:drug effects; D066127:White Matter / Q000187:drug effects*
chemical_list: D003692:Delayed-Action Preparations; D000068882:Paliperidone Palmitate
keywords: Schizophrenia; neuroimaging; paliperidone; treatment response; white-matter connectivity