title: miR-492G>C polymorphism (rs2289030) is associated with overall survival of hepatocellular carcinoma patients.
abstract: Single-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) are considered potential markers of cancer risk and prognosis in various cancers. In the current study, the primary aim is to determine whether the miR-492G>C polymorphism (rs2289030) altered hepatocellular carcinoma (HCC) prognosis. The SNP rs2289030 of miR-492 was genotyped using DNA from blood samples of 362 HCC patients that had undergone surgical resection of a HCC tumor. The associations between overall survival and demographic characteristics, clinical features, and the SNP rs2289030 were estimated using the Cox proportional hazards model. Results showed that patients who carried the CG genotype (P  = 0.015, hazard ratio [HR] = 0.704, 95 % confidence interval [CI] 0.530-0.934) and CG+GG genotype (P = 0.011, HR = 0.703, 95 % CI 0.536-0.924) had significantly decreased risk of death compared to those with the CC genotype. Similar results were found in the multivariate analysis adjusted by tumor size and venous invasion. Further stratification analysis indicated that the effect of rs2289030 had more prominence in patients ≤50 years old and that reported ever using alcohol, male gender, a family history of HCC, being HbsAg or alpha fetoprotein (AFP) positive, differentiation I + II, presence of venous invasion or cirrhosis, multiple tumors, and pTNM stage I + II. Results from this study illustrate the potential use of miR-492 rs2289030 as a prognostic marker for HCC patients that have undergone a surgical resection of the tumor.
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.|Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.|Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.|Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Guopeng
authors.initials: G
authors.lastname: Yu
authors.affiliation: Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Qianyi
authors.initials: Q
authors.lastname: Xiao
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Xiao-Pin
authors.initials: XP
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Xubo
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Zhuqing
authors.initials: Z
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Lu-Yao
authors.initials: LY
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Pengyin
authors.initials: P
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Dong-Lin
authors.initials: DL
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Hui-Xing
authors.initials: HX
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Hexige
authors.initials: H
authors.lastname: Saiyin
authors.affiliation: Qidong Liver Cancer Institute, Qidong People's Hospital, Qidong, Jiangsu, China.
authors.forename: Tao-Yang
authors.initials: TY
authors.lastname: Chen
authors.affiliation: Qidong Liver Cancer Institute, Qidong People's Hospital, Qidong, Jiangsu, China.
authors.forename: Pei-Xin
authors.initials: PX
authors.lastname: Lu
authors.affiliation: Qidong Liver Cancer Institute, Qidong People's Hospital, Qidong, Jiangsu, China.
authors.forename: Neng-Jin
authors.initials: NJ
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Yu
authors.affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Jielin
authors.initials: J
authors.lastname: Sun
authors.affiliation: Center for Genomic Cancer Research, NorthShore University HealthSystem, The University of Chicago, Chicago, IL, USA.
authors.forename: Carly
authors.initials: C
authors.lastname: Conran
authors.affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.|Center for Genomic Cancer Research, NorthShore University HealthSystem, The University of Chicago, Chicago, IL, USA.
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.|Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.|Center for Genomic Cancer Research, NorthShore University HealthSystem, The University of Chicago, Chicago, IL, USA.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Institute of Biomedical Science, Fudan University, Shanghai, China.
authors.forename: Long
authors.initials: L
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China. dekejiang@fudan.edu.cn.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China. dekejiang@fudan.edu.cn.|Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China. dekejiang@fudan.edu.cn.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China. dekejiang@fudan.edu.cn.|Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. dekejiang@fudan.edu.cn.|Center for Genomic Cancer Research, NorthShore University HealthSystem, The University of Chicago, Chicago, IL, USA. dekejiang@fudan.edu.cn.
authors.forename: De-Ke
authors.initials: DK
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C558125:MIRN492 microRNA, human; D035683:MicroRNAs
keywords: Genetic polymorphisms; Hepatocellular carcinoma; Survival; miRNA