title: Cholesteryl ester transfer protein gene polymorphism (I405V) and premature coronary artery disease in an Iranian population.
abstract: The effect of human cholesteryl ester transfer protein (CETP) expression on atherogenesis is still under debate. The rs5882 (I405V) polymorphism affect CETP function. We aimed to examine the relationship between the rs5882 polymorphism and the risk of angiographically determined coronary artery disease (CAD). To define premature CAD (PCAD), an age cutoff of 55 years for women and 45 years for men was used. An age- and sex-matched case-control study was conducted in 560 patients with newly diagnosed angiographically documented PCAD (≥50% luminal stenosis of any coronary vessel) and an equal number of control patients with normal coronary arteries (no luminal stenosis at coronary arteries). The severity of CAD was determined by vessel score and Gensini score. A real-time polymerase chain reaction (PCR) and high resolution melting analysis were used to distinguish between genotypes. The I405V genotype distributions were not statistically different in CAD and non-CAD groups in univariate and multivariable-adjusted logistic regression analyzes. The median and inter-quartile range for Gensini score was not significantly different among the AA (43, 24 to 73), AG (40, 20 to 66), and GG (45, 25 to 72) genotypes (p = 0.097). Furthermore, the distribution of vessel score did not statistically differ between these genotypes (p = 0.691). Our results suggest that there is no significant association between CETP I405V polymorphism and the risk of PCAD presence and severity. Larger prospective studies are needed to investigate such associations in different populations.
authors.affiliation: Department of Cardiac Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. hami_nag@yahoo.com.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Goodarzynejad
authors.forename: Mohammadali
authors.initials: M
authors.lastname: Boroumand
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Behmanesh
authors.forename: Shayan
authors.initials: S
authors.lastname: Ziaee
authors.forename: Arash
authors.initials: A
authors.lastname: Jalali
mesh_terms: D000328:Adult; D000367:Age Factors; D050197:Atherosclerosis / Q000453:epidemiology / Q000235:genetics; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007492:Iran / Q000453:epidemiology; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins