title: Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp(3) )-H and δ-C-H Bonds with an Oxazoline-Carboxylate Auxiliary.
abstract: A palladium-catalyzed arylation of unactivated γ-methylene C(sp(3) )H and remote δ-CH bonds by using an oxazoline-carboxylate directing group has been developed. Arylation occurs with a broad substrate scope and high tolerance of functional groups (i.e., halogen, nitro, cyano, ether, trifluoromethyl, amine, and ester). The oxazoline-type auxiliary can be removed under acidic conditions.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027 (P.R. China).
authors.forename: Peng-Xiang
authors.initials: PX
authors.lastname: Ling
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027 (P.R. China).
authors.forename: Sheng-Long
authors.initials: SL
authors.lastname: Fang
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027 (P.R. China).
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Yin
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027 (P.R. China).
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027 (P.R. China).
authors.forename: Bo-Zheng
authors.initials: BZ
authors.lastname: Sun
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027 (P.R. China). bfshi@zju.edu.cn.
authors.forename: Bing-Feng
authors.initials: BF
authors.lastname: Shi
keywords: CH activation; arylation; directing groups; oxazolines; palladium