title: Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study.
abstract: Curcumin is an antioxidant agent with both radiosensitizing and radioprotective properties. The aim of the present study was to evaluate the effect of curcumin supplementation on oxidative status of patients with prostate cancer who undergo radiotherapy. Forty patients treated with radiotherapy for prostate cancer were randomized to the curcumin (CG, n = 20) or placebo group (PG, n = 20). They received curcumin (total 3 g/day) or placebo during external-beam radiation therapy of up to 74 Gy. Plasma total antioxidant capacity (TAC) and activity of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) were measured at baseline and 3 mo after radiotherapy completion. Analysis of covariance was used to compare the variables between groups following the intervention. Serum PSA levels and MRI/MRS images were investigated. In CG, TAC significantly increased (P < 0.001) and the activity of SOD decreased (P = 0.018) after radiotherapy compared with those at baseline. In CG, however, the activity of SOD had a significant reduction (P = 0.026) and TAC had a significant increase (P = 0.014) compared with those in PG. PSA levels were reduced to below 0.2 ng/ml in both groups, 3 mo after treatment, however, no significant differences were observed between the 2 groups regarding treatment outcomes.
authors.affiliation: a Department of Biochemistry and Nutrition , Faculty of Medicine, Zanjan University of Medical Sciences , Zanjan , Iran.
authors.forename: Jalal
authors.initials: J
authors.lastname: Hejazi
authors.affiliation: b Independent Researcher , Tehran , Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Rastmanesh
authors.affiliation: c Department of Clinical Nutrition and Dietetics , Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Forough-Azam
authors.initials: FA
authors.lastname: Taleban
authors.affiliation: c Department of Clinical Nutrition and Dietetics , Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Seyed-Hadi
authors.initials: SH
authors.lastname: Molana
authors.affiliation: c Department of Clinical Nutrition and Dietetics , Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Hejazi
authors.affiliation: d Department of Radiation Oncology , Beasat Hospital, Armey Medical Sciences University , Tehran , Iran.
authors.forename: Golamreza
authors.initials: G
authors.lastname: Ehtejab
authors.affiliation: e Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University , Niigata , Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Hara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002374:Catalase / Q000378:metabolism; D003474:Curcumin / Q000008:administration & dosage*; D019587:Dietary Supplements; D004311:Double-Blind Method; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010084:Oxidation-Reduction; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D002374:Catalase; D013482:Superoxide Dismutase; D017430:Prostate-Specific Antigen; D003474:Curcumin