title: Effect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials.
abstract: Many individual studies on oat β-glucan (OBG) confirmed its functionality in improving type 2 diabetes mellitus (T2DM), but disagreements were identified among those results. To derive a pooled estimate of these results, relevant articles, published before 5 September 2015, were collected from four electronic databases (Pubmed, Cochrane Library, Scopus, and Web of Science) and subjected to meta-analysis in the present work. In total, four articles, dealing with 350 T2DM patients combined, met the inclusion criteria. Compared to control, T2DM patients administrated OBG from 2.5 to 3.5 g/day for 3 to 8 weeks presented significantly lowered concentrations in fasting plasma glucose (FPG) by -0.52 (95% CI: -0.94, -0.10) mmol/L (p = 0.01) and glycosylated hemoglobin (HbA1c) by -0.21% (95% CI: -0.40, -0.02) (p = 0.03). However, OBG intake did not significantly lower the fasting plasma insulin (FPI) concentration. In conclusion, mediate-term OBG intake (3-8 weeks) favored the glycaemic control of T2DM patients but did not improve their insulin sensitivity. Regrettably, data upon the effects of long-term OBG intake on glycaemic control and insulin sensitivity were scarce, which is of much importance and should be addressed in future research.
authors.affiliation: School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou, China. xiaolishen1983@163.com.
authors.forename: Xiao Li
authors.initials: XL
authors.lastname: Shen
authors.affiliation: School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou, China. 15186613384@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhao
authors.affiliation: School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou, China. zhouyuanzhong@163.com.
authors.forename: Yuanzhong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou, China. xqshi@zmc.edu.cn.
authors.forename: Xiuquan
authors.initials: X
authors.lastname: Shi
authors.affiliation: School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou, China. zouyan54321@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zou
authors.affiliation: College of Food Science, Southwest University, Chongqing 400716, China. zhaogh@swu.edu.cn.|Chongqing Engineering Research Centre of Regional Foods, Chongqing 400716, China. zhaogh@swu.edu.cn.
authors.forename: Guohua
authors.initials: G
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D005215:Fasting / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000187:drug effects*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D047071:beta-Glucans / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D047071:beta-Glucans; C517652:hemoglobin A1c protein, human; C067858:beta-glucan, (1-3)(1-4)-
keywords: diabetes mellitus; glycaemic control; insulin sensitivity; meta-analysis; oat β-glucan