title: Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia.
abstract: Preeclampsia is a disease of pregnancy involving systemic endothelial dysfunction. However, cardiovascular consequences of preeclampsia are difficult to analyze in humans. The objective of the present study is to evaluate the cardiovascular dysfunction induced by preeclampsia by examining the endothelium of mice suffering of severe preeclampsia induced by STOX1 overexpression. Using Next Generation Sequencing on endothelial cells of mice carrying either transgenic or control embryos, we discovered significant alterations of gene networks involved in inflammation, cell cycle, and cardiac hypertrophy. In addition, the heart of the preeclamptic mice revealed cardiac hypertrophy associated with histological anomalies. Bioinformatics comparison of the networks of modified genes in the endothelial cells of the preeclamptic mice and HUVECs exposed to plasma from preeclamptic women identified striking similarities. The cardiovascular alterations in the pregnant mice are comparable to those endured by the cardiovascular system of preeclamptic women. The STOX1 mice could help to better understand the endothelial dysfunction in the context of preeclampsia, and guide the search for efficient therapies able to protect the maternal endothelium during the disease and its aftermath.
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Ducat
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Ludivine
authors.initials: L
authors.lastname: Doridot
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Rosamaria
authors.initials: R
authors.lastname: Calicchio
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Celine
authors.initials: C
authors.lastname: Méhats
authors.affiliation: Unité Mixtes de Recherche1313 Génétique Animale et Biologie Intégrative, Institut National de la Recherche Agronomique Jouy-en-Josas, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Vilotte
authors.affiliation: Unité Mixtes de Recherche1313 Génétique Animale et Biologie Intégrative, Institut National de la Recherche Agronomique Jouy-en-Josas, France.
authors.forename: Johann
authors.initials: J
authors.lastname: Castille
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Barbaux
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Betty
authors.initials: B
authors.lastname: Couderc
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Jacques
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Franck
authors.initials: F
authors.lastname: Letourneur
authors.affiliation: Genetics and Endocrine Oncology, Hôpital de la Conception Assistance PubliqueHopitaux de Marseille, Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Buffat
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Fabien
authors.initials: F
authors.lastname: Le Grand
authors.affiliation: Unidad de Genética. Grupo GENIUROS. Escuela de Medicina y Ciencias de la Salud. Universidad del Rosario. Bogotá, Colombia.
authors.forename: Paul
authors.initials: P
authors.lastname: Laissue
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Francisco
authors.initials: F
authors.lastname: Miralles
authors.affiliation: Inserm, U1016, Institut Cochin, Paris, France.|Cnrs, UMR8104, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|DHU Risques et Grossesse, PRES Sorbonne Paris Cité, 53 avenue de l'observatoire, 75014 Paris.
authors.forename: Daniel
authors.initials: D
authors.lastname: Vaiman
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000209:etiology* / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002460:Cell Line; D016000:Cluster Analysis; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism* / Q000401:mortality; D011247:Pregnancy; D011485:Protein Binding; D025941:Protein Interaction Mapping; D060066:Protein Interaction Maps; D059467:Transcriptome
chemical_list: D002352:Carrier Proteins; C500784:STOX1 protein, human