title: Soluble ST2 Testing: A Promising Biomarker in the Management of Heart Failure.
abstract: ST2 is a member of the interleukin-1 receptor family biomarker and circulating soluble ST2 concentrations are believed to reflect cardiovascular stress and fibrosis. Recent studies have demonstrated soluble ST2 to be a strong predictor of cardiovascular outcomes in both chronic and acute heart failure. It is a new biomarker that meets all required criteria for a useful biomarker. Of note, it adds information to natriuretic peptides (NPs) and some studies have shown it is even superior in terms of risk stratification. Since the introduction of NPs, this has been the most promising biomarker in the field of heart failure and might be particularly useful as therapy guide.
authors.affiliation: Universidade Federal Fluminense, Niterói, RJ, Brazil.
authors.forename: Humberto
authors.initials: H
authors.lastname: Villacorta
authors.affiliation: Division of Cardiovascular Medicine, University of California, San Diego, United States.
authors.forename: Alan S
authors.initials: AS
authors.lastname: Maisel
mesh_terms: D015415:Biomarkers / Q000097:blood; D019468:Disease Management; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000097:blood*; D012016:Reference Values; D018570:Risk Assessment / Q000379:methods; D012995:Solubility; D013997:Time Factors
chemical_list: D015415:Biomarkers; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011956:Receptors, Cell Surface