title: Exploring mild enzymatic sustainable routes for the synthesis of bio-degradable aromatic-aliphatic oligoesters.
abstract: The application of Candida antarctica lipase B in enzyme-catalyzed synthesis of aromatic-aliphatic oligoesters is here reported. The aim of the present study is to systematically investigate the most favorable conditions for the enzyme catalyzed synthesis of aromatic-aliphatic oligomers using commercially available monomers. Reaction conditions and enzyme selectivity for polymerization of various commercially available monomers were considered using different inactivated/activated aromatic monomers combined with linear polyols ranging from C2 to C12 . The effect of various reaction solvents in enzymatic polymerization was assessed and toluene allowed to achieve the highest conversions for the reaction of dimethyl isophthalate with 1,4-butanediol and with 1,10-decanediol (88 and 87% monomer conversion respectively). Mw as high as 1512 Da was obtained from the reaction of dimethyl isophthalate with 1,10-decanediol. The obtained oligomers have potential applications as raw materials in personal and home care formulations, for the production of aliphatic-aromatic block co-polymers or can be further functionalized with various moieties for a subsequent photo- or radical polymerization.
authors.affiliation: University of Natural Resources and Life Sciences Vienna, Institute for Environmental Biotechnology, Tulln an der Donau, Austria.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pellis
authors.affiliation: Laboratory of Applied and Computational Biocatalysis, Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Trieste, Italy.|Erasmus traineeship plus program at University of Natural Resources and Life Sciences, Institute for Environmental Biotechnology, Tulln an der Donau, Austria.
authors.forename: Alice
authors.initials: A
authors.lastname: Guarneri
authors.affiliation: Austrian Centre of Industrial Biotechnology GmbH, Tulln an der Donau, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Brandauer
authors.affiliation: Austrian Centre of Industrial Biotechnology GmbH, Tulln an der Donau, Austria. enrique.herreroacero@acib.at.
authors.forename: Enrique Herrero
authors.initials: EH
authors.lastname: Acero
authors.affiliation: Clariant Produkte (Deutschland) GmbH, Frankfurt am Main, Germany.
authors.forename: Henricus
authors.initials: H
authors.lastname: Peerlings
authors.affiliation: Laboratory of Applied and Computational Biocatalysis, Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Trieste, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Gardossi
authors.affiliation: University of Natural Resources and Life Sciences Vienna, Institute for Environmental Biotechnology, Tulln an der Donau, Austria.|Austrian Centre of Industrial Biotechnology GmbH, Tulln an der Donau, Austria.
authors.forename: Georg M
authors.initials: GM
authors.lastname: Guebitz
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D055162:Biocatalysis; D002072:Butylene Glycols / Q000737:chemistry; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D005233:Fatty Alcohols / Q000737:chemistry; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism*; D008049:Lipase / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D010795:Phthalic Acids / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000737:chemistry; D014050:Toluene / Q000737:chemistry
chemical_list: D000438:Alcohols; D002072:Butylene Glycols; D004800:Enzymes, Immobilized; D005233:Fatty Alcohols; D005656:Fungal Proteins; D010795:Phthalic Acids; D011091:Polyesters; D011108:Polymers; C024617:polyol; D014050:Toluene; C118975:1,10-decanediol; C039681:1,4-butanediol; D008049:Lipase; C431349:lipase B, Candida antarctica
keywords: Cell activation; Cell death; Extracellular vesicles (EV) concentration; Industrial bioprocess; Microenvironment