title: SELF-REPORTED MEDICATION ADHERENCE IN PATIENTS WITH END-STAGE KIDNEY DISEASE UNDERGOING ONLINE-HAEMODIAFILTRATION.
abstract: BACKGROUND
  Non-adherence to therapeutic regimens is a recognised problem in the dialysis population that compromises the opportunity to achieve maximum treatment effect and, therefore, might lead to increased morbidity and mortality. In this study, we aimed to evaluate the prevalence of self-reported medication non-adherence in patients with end-stage kidney disease (ESKD) undergoing online-haemodiafiltration (OL-HDF), as well as to evaluate the factors that could affect medication adherence.
  
  
  METHODS
  We evaluated 122 patients with ESKD undergoing OL-HDF. Patients' reported medication adherence was measured by the Measure Treatment Adherence (MTS) scale. Social support was evaluated by the abbreviated Lubben Social Network Scale (LSNS); depression status by the Geriatric Depression Scale (GDS). Socio-demographic, co-morbidity and clinical data were also evaluated.
  
  
  RESULTS
  Our results showed that 10.7% of patients with ESKD perceived themselves as non-adherent to medication. When two groups of patients (adherent and non-adherents) were compared, significantly higher levels of triglycerides, and higher diastolic and systolic blood pressure were found in the non-adherent group. Significant correlations were found between the MTS score, and diastolic blood pressure, age and GDS score. Multiple regression analysis identified age and the GDS score as independent variables significantly associated with the MTS score.
  
  
  CONCLUSIONS
  Non-adherence to therapeutic regimens in patients with ESKD is associated with higher levels of triglycerides and higher blood pressure and are, therefore, at a higher cardiovascular risk. Moreover, we found that age and depression status are important variables in non-adherence to therapeutic regimens.
authors.affiliation: Nephrocare Portugal, SA-Nephrocare Maia, Maia, Portugal.
authors.forename: Leonilde
authors.initials: L
authors.lastname: Amado
authors.affiliation: Nephrocare Portugal, SA-Nephrocare Maia, Maia, Portugal.
authors.forename: Nuno
authors.initials: N
authors.lastname: Ferreira
authors.affiliation: Nephrocare Portugal, SA-Nephrocare Maia, Maia, Portugal.
authors.forename: Vasco
authors.initials: V
authors.lastname: Miranda
authors.affiliation: Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.|Dr. Francisco Zagalo Hospital, Ovar, Portugal.
authors.forename: Patricia
authors.initials: P
authors.lastname: Meireles
authors.affiliation: UNIFAI, Unit of Research and Training in Adults and Elderly, University of Porto, Porto, Portugal.
authors.forename: Verónica
authors.initials: V
authors.lastname: Povera
authors.affiliation: Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ferreira
authors.affiliation: Nephrocare Portugal, SA-Nephrocare Maia, Maia, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Fazendeiro-Matos
authors.affiliation: Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.|UNIFAI, Unit of Research and Training in Adults and Elderly, University of Porto, Porto, Portugal.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Teixeira
authors.affiliation: Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.|UNIFAI, Unit of Research and Training in Adults and Elderly, University of Porto, Porto, Portugal.
authors.forename: Constança
authors.initials: C
authors.lastname: Paúl
authors.affiliation: Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.|UCIBIO@REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.
authors.forename: Alice
authors.initials: A
authors.lastname: Santos-Silva
authors.affiliation: Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.|UCIBIO@REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.
authors.forename: Elísio
authors.initials: E
authors.lastname: Costa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D017583:Hemodiafiltration / Q000706:statistics & numerical data*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008297:Male; D055118:Medication Adherence / Q000523:psychology; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D057566:Self Report; D011795:Surveys and Questionnaires; D016903:Drug Monitoring
keywords: Adherence; Depression; Dialysis; Haemofiltration