title: Correlation between bone mineral density and serum trace element contents of elderly males in Beijing urban area.
abstract: Trace element levels are associated with the incidence of osteoporotic fractures, but related mechanisms remain unknown. Trace elements may interfere with growth, development and maintenance of bones. Therefore, we investigated whether plasma trace element levels are associated with bone mineral density in elderly males in Beijing. After epidemiologically investigating 91 elderly males with age ranging from 50 years to 80 years, we obtained a total of 30 healthy (group 1), 31 osteopoenic (group 2) and 30 osteoporotic (group 3) subjects. Blood was collected, and serum concentrations of trace elements were detected. Elderly males in the three groups were carefully matched in terms of body mass index. Iron, manganese, zinc, copper, selenium, cadmium and lead were analysed by inductively coupled plasma-mass spectrometry. Bone mineral density (BMD) was measured by QDR-2000 dual-energy X-ray absorptiometry. Correlation between BMD and serum element contents was analysed using SPSS16.0. The plasma levels of manganese, zinc, copper, selenium and lead were similar in all of the groups (P>0.05). Cadmium was significantly and negatively correlated with BMD of the lumbar vertebrae (P<0.05). Moreover, cadmium and iron contents significantly differed in osteoporotic and healthy groups. These elements may directly and correlatively affect BMD in elderly males. Many trace elements may directly and correlatively influence BMD. Future studies should be conducted to evaluate serum and bone levels of these trace elements to determine the relationship of these trace elements with osteoporosis.
authors.affiliation: Center of Orthopedics, 309 Hospital of PLA Beijing 100091, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Center of Orthopedics, 309 Hospital of PLA Beijing 100091, China.
authors.forename: Haotian
authors.initials: H
authors.lastname: Yu
authors.affiliation: Center of Orthopedics, 309 Hospital of PLA Beijing 100091, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Yang
authors.affiliation: Center of Orthopedics, 309 Hospital of PLA Beijing 100091, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center of Orthopedics, 309 Hospital of PLA Beijing 100091, China.
authors.forename: Wenjiao
authors.initials: W
authors.lastname: Wang
authors.affiliation: Center of Orthopedics, 309 Hospital of PLA Beijing 100091, China.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Su
authors.affiliation: Center of Orthopedics, 309 Hospital of PLA Beijing 100091, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Ma
authors.affiliation: Center of Orthopedics, 309 Hospital of PLA Beijing 100091, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Center of Orthopedics, 309 Hospital of PLA Beijing 100091, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Chen
authors.affiliation: Division of Science and Technology, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention Beijing 100050, China.
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.affiliation: Center of Orthopedics, 309 Hospital of PLA Beijing 100091, China.
authors.forename: Yuanzheng
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Center for Systems Biomedical Sciences, University of Shanghai for Science and Technology Shanghai 200093, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
keywords: Osteoporosis; bone mineral density; element