title: Origins of cardiac fibroblasts.
abstract: Cardiac fibroblasts produce the extracellular matrix (ECM) scaffold within which the various cellular components of the heart are organized. As well as providing structural support, it is becoming evident that the quality and quantity of ECM is a key factor for determining cardiac cell behavior during development and in pathological contexts such as heart failure involving fibrosis. Cardiac fibroblasts have long remained a poorly characterized cardiac lineage. Well characterized markers are now paving the way for a better understanding of the roles of these cells in various developmental and disease contexts. Notably, the relevance of processes including endothelial-tomesenchymal transition and the recruitment of circulating fibroblast progenitors in heart failure has been challenged. This review describes the latest findings on cardiac fibroblast markers and developmental origins, and discusses their importance in myocardial remodeling. Effective modulation of cardiac fibroblast activity would likely contribute to successful treatment of various cardiac disorders.
authors.affiliation: INSERM UMRS_910, Aix-Marseille Université, Marseille, France. Electronic address: thomas.moore-morris@univ-amu.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Moore-Morris
authors.affiliation: Skaggs School of Pharmacy, UCSD, La Jolla, CA, USA.
authors.forename: Paola
authors.initials: P
authors.lastname: Cattaneo
authors.affiliation: INSERM UMRS_910, Aix-Marseille Université, Marseille, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Puceat
authors.affiliation: Skaggs School of Pharmacy, UCSD, La Jolla, CA, USA; Department of Medicine, UCSD, La Jolla, CA, USA; Department of Pharmacology, UCSD, La Jolla, CA, USA.
authors.forename: Sylvia M
authors.initials: SM
authors.lastname: Evans
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D019070:Cell Lineage / Q000502:physiology*; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism; D000070818:Discoidin Domain Receptors; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology*; D005355:Fibrosis; D015870:Gene Expression; D006333:Heart Failure / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000235:genetics / Q000378:metabolism; D011975:Receptors, Mitogen / Q000235:genetics / Q000378:metabolism; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D015415:Biomarkers; D024042:Collagen Type I; D000070818:Discoidin Domain Receptors; D020794:Receptor Protein-Tyrosine Kinases; D020797:Receptor, Platelet-Derived Growth Factor beta; D011975:Receptors, Mitogen; D020825:T-Box Domain Proteins; C491825:TCF21 protein, human; C523796:Tbx18 protein, human; C000605860:PDGFRB protein, human
keywords: Cardiac lineage; Fibroblast; Fibroblast markers; Fibrosis; Hypertrophy; Myocardial infarction