title: Synergy Effects of Three Plant Extracts on Protection of Gastric Mucosa.
abstract: The gastric mucosa protection effect of three natural plant extracts, Hericium erinaceus (HE), Centella asiatica (CA) and Amomum villosum (AV), were evaluated using the indomethacin damage model. Compared with a single extract, a combination of HE/CA/AV, especially with the ratios of 80:10:10, 45:45:10 and 45:10:45, showed significant synergistic effects for protection of the gastric mucosa with gastric ulcer inhibition rates of 97.8 ± 0.7%, 86.5 ± 2.8% and 86.1 ± 3.6%, respectively. Microscopic appearances of the gastric mucosa were carried out to help confirm the results.
authors.forename: Caihui
authors.initials: C
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Su
authors.forename: Xingli
authors.initials: X
authors.lastname: Su
authors.forename: Guojun
authors.initials: G
authors.lastname: Ni
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Kong
mesh_terms: D035801:Amomum / Q000737:chemistry*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D001487:Basidiomycota / Q000737:chemistry*; D028041:Centella / Q000737:chemistry*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts