title: Ruthenium Catalyzed Intramolecular C-S Coupling Reactions: Synthetic Scope and Mechanistic Insight.
abstract: A ruthenium catalyzed intramolecular C-S coupling reaction of N-arylthioureas for the synthesis of 2-aminobenzothiazoles has been developed. Kinetic, isotope labeling, and computational studies reveal the involvement of an electrophilic ruthenation pathway instead of a direct C-H activation. Stereoelectronic effect of meta-substituents on the N-arylthiourea dictates the final regioselective outcome of the reaction.
authors.affiliation: Department of Chemistry, ‡Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan , Bandarsindri, Kishangarh - 305 817, Rajasthan, India.
authors.forename: Shivani
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Chemistry, ‡Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan , Bandarsindri, Kishangarh - 305 817, Rajasthan, India.
authors.forename: Ramdas S
authors.initials: RS
authors.lastname: Pathare
authors.affiliation: Department of Chemistry, ‡Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan , Bandarsindri, Kishangarh - 305 817, Rajasthan, India.
authors.forename: Antim K
authors.initials: AK
authors.lastname: Maurya
authors.affiliation: Department of Chemistry, ‡Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan , Bandarsindri, Kishangarh - 305 817, Rajasthan, India.
authors.forename: Kandasamy
authors.initials: K
authors.lastname: Gopal
authors.affiliation: Department of Chemistry, ‡Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan , Bandarsindri, Kishangarh - 305 817, Rajasthan, India.
authors.forename: Tapta Kanchan
authors.initials: TK
authors.lastname: Roy
authors.affiliation: Department of Chemistry, ‡Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan , Bandarsindri, Kishangarh - 305 817, Rajasthan, India.
authors.forename: Devesh M
authors.initials: DM
authors.lastname: Sawant
authors.affiliation: Department of Chemistry, ‡Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan , Bandarsindri, Kishangarh - 305 817, Rajasthan, India.
authors.forename: Ram T
authors.initials: RT
authors.lastname: Pardasani