title: Glucose Profiles in Pregnant Women After a Gastric Bypass : Findings from Continuous Glucose Monitoring.
abstract: The diagnosis of gestational diabetes mellitus (GDM) usually requires an oral glucose tolerance test, but this procedure seems inappropriate after gastric bypass surgery (Roux-en-Y gastric bypass (RYGB)) due to specific altered glycemic responses. We aimed here at describing continuous glucose monitoring (CGM) profile of pregnant women after RYGB.
  
  
  
  CGM was performed in 35 consecutive pregnant women after RYGB at 26.2 ± 5 weeks of gestation.
  
  
  
  After RYGB, pregnant women display high postprandial interstitial glucose (IG) peaks and low IG before and 2 h after meals. The postprandial IG peak is reached early, within 54 ± 9 min. The maximum IG values reach 205 mg/dl, and the percentage of time above 140 mg/dl (6.6 ± 7 %) is similar to what is described in GDM women.
  
  
  
  This study is the first to describe CGM profile in pregnant women after RYGB. CGM features are similar to those of non-pregnant post-RYGB patients, characterized by wide and rapid changes in postprandial IG, and high exposure to hyperglycemia. The exposure to hyperglycemia is similar to what is reported in GDM although the time to postprandial peak is shorter. CGM could be an additional useful approach to screen for glucose intolerance during pregnancy after RYGB.
authors.affiliation: Department of Diabetology, Metabolic Diseases, and Nutrition, CHU Toulouse, Toulouse, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Bonis
authors.affiliation: Department of Diabetology, Metabolic Diseases, and Nutrition, CHU Toulouse, Toulouse, France.|Department of Obstetrics and Gynecology, Paule de Viguier Hospital, CHU of Toulouse, Toulouse, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Lorenzini
authors.affiliation: Nutrition Unit, Cardiovascular and Metabolism Division, Larrey Hospital, CHU of Toulouse, Toulouse, France.
authors.forename: Monelle
authors.initials: M
authors.lastname: Bertrand
authors.affiliation: Department of Obstetrics and Gynecology, Paule de Viguier Hospital, CHU of Toulouse, Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Parant
authors.affiliation: Department of Diabetology, Metabolic Diseases, and Nutrition, CHU Toulouse, Toulouse, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Gourdy
authors.affiliation: Department of Diabetology, Metabolic Diseases, and Nutrition, CHU Toulouse, Toulouse, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Vaurs
authors.affiliation: Department of Diabetology, Metabolic Diseases, and Nutrition, CHU Toulouse, Toulouse, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Cazals
authors.affiliation: Nutrition Unit, Cardiovascular and Metabolism Division, Larrey Hospital, CHU of Toulouse, Toulouse, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Ritz
authors.affiliation: Department of Diabetology, Metabolic Diseases, and Nutrition, CHU Toulouse, Toulouse, France. hanaire.h@chu-toulouse.fr.|University of Toulouse 3, Toulouse, France. hanaire.h@chu-toulouse.fr.
authors.forename: Hélène
authors.initials: H
authors.lastname: Hanaire
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015331:Cohort Studies; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods*; D009767:Obesity, Morbid / Q000453:epidemiology / Q000601:surgery; D019518:Postprandial Period; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology
chemical_list: D001786:Blood Glucose
keywords: (MESH) bariatric surgery; Blood glucose self monitoring; Continuous glucose monitoring; Gastric bypass; Gestational diabetes; Pregnancy