title: Worse Neurological State During Acute Ischemic Stroke is Associated with a Decrease in Serum Albumin Levels.
abstract: High serum albumin levels during ischemic stroke (IS) decrease the risk of a poor outcome. This study aimed to determine whether serum albumin levels within the first days after IS correlate with radiological and biochemical markers of brain tissue damage. Fifty-six IS patients were enrolled into the study. Neurological examinations were based on the National Institute of Health Stroke Scale. Serum albumin levels and S100BB were evaluated using commercially available ELISA kits. The albumin decrease index (ADI) was calculated as the difference between serum albumin levels measured on days 1 and 10 of IS. All parameters were estimated on the 1st, 3rd, 5th, and 10th days of IS, and the volume of ischemic focus was measured on the 10th day. Mean serum albumin levels were decreased during acute IS. There were correlations between the ADI and mean S100BB serum levels (r = 0.36, p < 0.05), the volume of ischemic focus (r = 0.39, p < 0.05), and the patients' neurological state when measured on day 10 of IS (r = 0.59, p < 0.001). A decrease in serum albumin levels during the acute phase of IS corresponds to a worse neurological state as a result of a large ischemic focus with intense catabolic processes.
authors.affiliation: Department of Neurology, Medical University of Lublin, Jaczewskiego 8, 20-954, Lublin, Poland. j.bielewicz@op.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Bielewicz
authors.affiliation: Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kurzepa
authors.affiliation: 1st Department of Radiology, Medical University of Lublin, Jaczewskiego 8, 20-954, Lublin, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Czekajska-Chehab
authors.affiliation: Department of Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954, Lublin, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Kamieniak
authors.affiliation: Institute of Psychology, Marie Curie-Skłodowska University in Lublin, Plac Litewski 5, 20-080, Lublin, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Daniluk
authors.affiliation: Department of Neurology, University of Rzeszow, Lwowska 60, 35-301, Rzeszow, Poland.
authors.forename: Halina
authors.initials: H
authors.lastname: Bartosik-Psujek
authors.affiliation: Department of Neurology, Medical University of Lublin, Jaczewskiego 8, 20-954, Lublin, Poland.
authors.forename: Konrad
authors.initials: K
authors.lastname: Rejdak
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood; D020521:Stroke / Q000097:blood* / Q000473:pathology
chemical_list: D000418:Albumins; D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human
keywords: Albumin; Ischemic stroke; Outcome; S100BB protein