title: Toward faster and higher resolution LA-ICPMS imaging: on the co-evolution of LA cell design and ICPMS instrumentation.
abstract: We describe trends in fast, high resolution elemental imaging by laser ablation-inductively coupled plasma mass spectrometry (LA-ICPMS). Recently developed low dispersion LA cells deliver quantitative transport of ablated aerosols within 10 ms and also provide enhanced sensitivity compared to conventional LA cells because the analyte ion signal becomes less diluted during aerosol transport. When connected to simultaneous ICPMS instruments, these low dispersion LA cells offer a platform for high speed and high lateral resolution shot-resolved LA-ICPMS imaging. Here, we examine the current paradigms of LA-ICPMS imaging and discuss how newly developed LA cell technology combined with simultaneous ICPMS instrumentation is poised to overcome current instrumental limitations to deliver faster, higher resolution elemental imaging.
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, 8093, Zurich, Switzerland. graham@inorg.chem.ethz.ch.
authors.forename: Alexander
authors.initials: A
authors.lastname: Gundlach-Graham
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, 8093, Zurich, Switzerland.
authors.forename: Detlef
authors.initials: D
authors.lastname: Günther
mesh_terms: D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*
keywords: Elemental imaging; ICPMS; Laser ablation; Mass spectrometry; Time-of-flight