title: Cell-Capture and Release Platform Based on Peptide-Aptamer-Modified Nanowires.
abstract: Nanowires have attracted much attention due to their potential bioapplications, such as delivery of drugs or sensing devices. Here we report the development of a unique cell-capture and release platform based on nanowires. The combination of nanowires, surface-binding peptides, and cell-targeting aptamers leads to specific and efficient capture of cancer cells. Moreover, the binding processes are reversible, which is not only useful for downstream analysis but also for reusability of the substrate. Our work provides a new method in the design of the cell-capture and release platform, which may open up new opportunities of developing cell-separation and diagnosis systems based on cell-capture techniques.
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Jingying
authors.initials: J
authors.lastname: Li
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Qi
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Lian
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Qiusen
authors.initials: Q
authors.lastname: Han
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Xinhuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Shuangfei
authors.initials: S
authors.lastname: Cai
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
mesh_terms: D000327:Adsorption; D052158:Aptamers, Peptide / Q000737:chemistry*; D005708:Gallium / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D008856:Microscopy, Fluorescence; D053770:Nanowires / Q000737:chemistry*
chemical_list: D052158:Aptamers, Peptide; C473348:gallium nitride; D005708:Gallium
keywords: GaN; aptamers; cell-capture; nanowires; peptides