title: Michaelis-Menten reaction scheme as a unified approach towards the optimal restart problem.
abstract: We study the effect of restart, and retry, on the mean completion time of a generic process. The need to do so arises in various branches of the sciences and we show that it can naturally be addressed by taking advantage of the classical reaction scheme of Michaelis and Menten. Stopping a process in its midst-only to start it all over again-may prolong, leave unchanged, or even shorten the time taken for its completion. Here we are interested in the optimal restart problem, i.e., in finding a restart rate which brings the mean completion time of a process to a minimum. We derive the governing equation for this problem and show that it is exactly solvable in cases of particular interest. We then continue to discover regimes at which solutions to the problem take on universal, details independent forms which further give rise to optimal scaling laws. The formalism we develop, and the results obtained, can be utilized when optimizing stochastic search processes and randomized computer algorithms. An immediate connection with kinetic proofreading is also noted and discussed.
authors.affiliation: School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Rotbart
authors.affiliation: Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
authors.forename: Shlomi
authors.initials: S
authors.lastname: Reuveni
authors.affiliation: School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Urbakh