title: Short Peptides and Telomere Length Regulator Hormone Irisin.
abstract: Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin content. The data suggest that the immunomodulatory peptide Lys-Glu and neuroprotective peptide Glu-Asp-Arg modulate the life span by modulating irisin gene expression.
authors.affiliation: Russian Academy of Sciences, I. P. Pavlov Institute of Physiology, Moskva, Russia.|St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.affiliation: Chita State Medical Academy, Ministry of Health of the Russian Federation, Chita, Russia.
authors.forename: B I
authors.initials: BI
authors.lastname: Kuznik
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.|St. Petersburg State Polytechnological University, St. Petersburg, Russia.
authors.forename: S I
authors.initials: SI
authors.lastname: Tarnovskaya
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. linkova@gerontology.ru.|St. Petersburg State Polytechnological University, St. Petersburg, Russia. linkova@gerontology.ru.
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic / Q000235:genetics; D005353:Fibronectins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D010455:Peptides / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000235:genetics*
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins; D010455:Peptides
keywords: epigenetics; irisin; short peptides; telomeres