title: Catch bond interaction allows cells to attach to strongly hydrated interfaces.
abstract: Hyaluronans are a class of glycosaminoglycans that are widespread in the mammalian body and serve a variety of functions. Their most striking characteristic is their pronounced hydrophilicity and their capability to inhibit unspecific adhesion when present at interfaces. Catch-bond interactions are used by the CD44 receptor to interact with this inert material and to roll on the surfaces coated with hyaluronans. In this minireview, the authors discuss the general properties of hyaluronans and the occurrence and relevance of the CD44 catch-bond interaction in the context of hematopoiesis, cancer development, and leukemia.
authors.affiliation: Department of Medicine V, University Hospital Heidelberg, Heidelberg 69120, Germany and Analytical Chemistry-Biointerfaces, Ruhr-University Bochum, Bochum 44801, Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Hanke-Roos
authors.affiliation: Applied Physical Chemistry, University of Heidelberg, Heidelberg 69120, Germany.
authors.forename: Georg R
authors.initials: GR
authors.lastname: Meseck
authors.affiliation: Analytical Chemistry-Biointerfaces, Ruhr-University Bochum, Bochum 44801, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Rosenhahn
mesh_terms: D002448:Cell Adhesion; D018960:Hyaluronan Receptors / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions
chemical_list: D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid