title: Role of Nitric Oxide Produced by Lactobacilli in Relaxation of Intestinal Smooth Muscles.
abstract: Application of NO-producing lactobacilli to a rat jejunum segment induced muscle relaxation that was potentiated after activation of bacterial NO production with NO synthase substrate L-arginine. Similar changes in the intestinal contractile activity were observed in response to exogenous NO formed by sodium nitroprusside. These results indicated the involvement of NO synthesized by probiotic lactobacilli in the regulation of the intestinal motor function.
authors.affiliation: Department of Microbiology, Kazan (Volga Region) Federal University, Kazan, Russia. kasfes@gmail.com.
authors.forename: D R
authors.initials: DR
authors.lastname: Yarullina
authors.affiliation: Department of Human and Animal Physiology, Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: R O
authors.initials: RO
authors.lastname: Mikheeva
authors.affiliation: Department of Human and Animal Physiology, Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: G I
authors.initials: GI
authors.lastname: Sabirullina
authors.affiliation: Department of Microbiology, Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: P V
authors.initials: PV
authors.lastname: Zelenikhin
authors.affiliation: Department of Microbiology, Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: O N
authors.initials: ON
authors.lastname: Ilinskaya
authors.affiliation: Department of Human and Animal Physiology, Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: G F
authors.initials: GF
authors.lastname: Sitdikova
mesh_terms: D000818:Animals; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D007778:Lactobacillus / Q000378:metabolism* / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats
chemical_list: D009599:Nitroprusside; D009569:Nitric Oxide
keywords: Lactobacillus plantarum; nitric oxide; rat jejunum; smooth musculature; spontaneous contractile activity