title: Simultaneous occurrence of Hodgkin's disease and tubercular lymphadenitis in the same cervical lymph node: a rare presentation.
abstract: Concomitant presentation of tuberculosis (TB) and lymphoma is a rare entity. A primary malignancy such as Hodgkin's disease (HD) may cause suppression of the cell-mediated immunity, which predisposes to a concomitant TB infection. We report a case of an 18-year-old man, who presented with fever and was found to have pallor, generalised lymphadenopathy, hepatosplenomegaly, ascites and pedal oedema. Ultrasound of the abdomen revealed enlarged lymph nodes in the para-aortic and peripancreatic region. On chest contrast-enhanced CT, calcified mediastinal lymph nodes were seen. A surgical biopsy of a cervical lymph node was performed, which revealed caseous necrosis surrounded by epithelioid cells along with diffuse nodal architectural effacement by large atypical lymphoid cells. Numerous Reed Sternberg cells were also seen. Immunohistochemistry confirmed diagnosis of Hodgkin's lymphoma. The same lymph node came out to be positive for mycobacterium TB on polymerised chain reaction. The patient was given antitubercular therapy concomitantly with chemotherapy for HD, and improved with treatment.
authors.affiliation: Department of Cardiology, IGMC Shimla, Shimla, Himachal Pradesh, India Doctor's Hostel Pg Hostel.
authors.forename: Kunal
authors.initials: K
authors.lastname: Mahajan
authors.affiliation: Department of ENT, IGMC, Shimla, Himachal Pradesh, India.
authors.forename: Gunjan
authors.initials: G
authors.lastname: Gupta
authors.affiliation: Department of Cardiology, IGMC Shimla, Shimla, Himachal Pradesh, India.
authors.forename: Davinder Pal
authors.initials: DP
authors.lastname: Singh
authors.affiliation: Department of ENT, IGMC, Shimla, Himachal Pradesh, India.
authors.forename: Aditi
authors.initials: A
authors.lastname: Mahajan
mesh_terms: D000293:Adolescent; D001706:Biopsy; D006689:Hodgkin Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009333:Neck / Q000473:pathology; D016539:Reed-Sternberg Cells / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014388:Tuberculosis, Lymph Node / Q000150:complications* / Q000473:pathology