title: Arthritis and osteoporosis: pathogenetic correlations in function of arthroplasty.
abstract: Osteoarthritis is being increasingly characterised as an inflammatory incoming and recurrent disease, with the specific symptoms of inflammation at every stage of the disease. With regard to the pathogenesis over time, the degenerative and inflammatory components are combined and lead to osteocartilaginous degeneration. Such deterioration involves other joint tissues as well as the subchondral bone tissue, the suffering of which is the key event of the beginning and progression of OA; its involvement concerns the same pathogenetic mechanisms and the same chemical mediators of the chondropathy. The increase in joint inflammatory events leads to suspect the onset or the worsening of the osteometabolic disorder, which is documented by the MR as bone edema or as algodystrophic syndrome. The pain appears both while moving and resting and with signs of inflammation. The treatment of OA requires drugs, such as paracetamol, selective and nonselective NSAIDs and opiates, for pain control. Treatment should ensure the pharmacological control of the pain related to the osteometabolic juxta-articular alteration, through bisphosphonates, favouring those which can control bone loss, inflammation and pain.
authors.affiliation: School of Medical and Pharmaceutical Sciences, Research Centre on Osteoporosis and Osteoarticular Diseases (CROPO) University of Genoa, Genoa, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Molfetta
authors.affiliation: School of Medical and Pharmaceutical Sciences, Research Centre on Osteoporosis and Osteoarticular Diseases (CROPO) University of Genoa, Genoa, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Seriolo
mesh_terms: D018771:Arthralgia / Q000209:etiology; D001178:Arthroplasty; D001696:Biomechanical Phenomena; D015519:Bone Density; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy / Q000209:etiology*; D010024:Osteoporosis / Q000209:etiology*