title: Calculating Stress: From Entropy to a Thermodynamic Concept of Health and Disease.
abstract: To date, contemporary science has lacked a satisfactory tool for the objective expression of stress. This text thus introduces a new-thermodynamically derived-approach to stress measurement, based on entropy production in time and independent of the quality or modality of a given stressor or a combination thereof. Hereto, we propose a novel model of stress response based on thermodynamic modelling of entropy production, both in the tissues/organs and in regulatory feedbacks. Stress response is expressed in our model on the basis of stress entropic load (SEL), a variable we introduced previously; the mathematical expression of SEL, provided here for the first time, now allows us to describe the various states of a living system, including differentiating between states of health and disease. The resulting calculation of stress response regardless of the type of stressor(s) in question is thus poised to become an entirely new tool for predicting the development of a living system.
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5 A18, Brno, 625 00, Czech Republic.
authors.forename: Julie
authors.initials: J
authors.lastname: Bienertová-Vašků
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5 A18, Brno, 625 00, Czech Republic.
authors.forename: Filip
authors.initials: F
authors.lastname: Zlámal
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5 A18, Brno, 625 00, Czech Republic.
authors.forename: Ivo
authors.initials: I
authors.lastname: Nečesánek
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5 A18, Brno, 625 00, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Konečný
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5 A18, Brno, 625 00, Czech Republic.
authors.forename: Anna
authors.initials: A
authors.lastname: Vasku
mesh_terms: D004194:Disease; D019277:Entropy; D006262:Health; D008962:Models, Theoretical; D013816:Thermodynamics