title: Incidence of peripheral arterial disease in the ARTPER population cohort after 5 years of follow-up.
abstract: BACKGROUND
  To know the epidemiology (prevalence, incidence, progression and morbidity and mortality associated) of peripheral artery disease in general population and the factors associated with this progression is essential to know the evolution of atherosclerosis and develop preventive strategies. The aim of the study was to determine the incidence of PAD after 5 years of follow-up population-based cohort ARTPER, and the evolution of Ankle brachial Index (ABI) in this period.
  
  
  METHODS
  Peripheral artery disease incidence analysis after 5 years of follow-up of 3786 subjects > 50 years old. Peripheral artery disease incident when the second cross section Ankle brachial Index was <0.9 in any of the lower limbs, with normal baseline (0.9 to 1.4).
  
  
  RESULTS
  Between 2012 and 2013 2762 individuals (77% participation) were re-examined . Finally analyzed 2256 subjects (after excluding pathological Ankle brachial Index) followed for 4.9 years (range 3.8 to 5.8 years), totalling 11,106 person-years. Peripheral artery disease 95 new cases were detected, representing an incidence of 4.3% at 5 years and 8.6 per 1000 person-years (95% CI 6.9 to 10.5) being higher in men (10.2, 95% CI 7.4 to 13.5) than in women (7.5, 95% CI 5.5 to 9.9). Linear correlation between the baseline Ankle brachial Index and the second cross section was low (r = 0.23).
  
  
  CONCLUSIONS
  The incidence of peripheral artery disease in ARTPER cohort was 8.6 cases per 1000 person-years, being higher in men, especially <65 years. The correlation between two measures Ankle brachial Index after 5 years of follow-up was low. One might consider whether Ankle brachial Index repeated measures could improve the correlation.
authors.affiliation: Primary Healthcare Centre Riu Nord-Riu Sud, Institut Català de la Salut, Santa Coloma de Gramenet, Barcelona, Spain. maiteal2007@gmail.com.|Research Unit Barcelonès Nord Maresme, ICS-IDIAP Jordi Gol, Barcelona, Spain. maiteal2007@gmail.com.
authors.forename: Ma Teresa
authors.initials: MT
authors.lastname: Alzamora
authors.affiliation: Primary Healthcare Centre Riu Nord-Riu Sud, Institut Català de la Salut, Santa Coloma de Gramenet, Barcelona, Spain.|Research Unit Barcelonès Nord Maresme, ICS-IDIAP Jordi Gol, Barcelona, Spain.|Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Forés
authors.affiliation: Research Unit Barcelonès Nord Maresme, ICS-IDIAP Jordi Gol, Barcelona, Spain.
authors.forename: Guillem
authors.initials: G
authors.lastname: Pera
authors.affiliation: Primary Healthcare Centre La Marina, Institut Català de la Salut, Barcelona, Spain.
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Baena-Díez
authors.affiliation: Primary Healthcare Centre Riu Nord-Riu Sud, Institut Català de la Salut, Santa Coloma de Gramenet, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Heras
authors.affiliation: Primary Healthcare Centre Numància, Institut Català de la Salut, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Sorribes
authors.affiliation: Primary Healthcare Centre Riu Nord-Riu Sud, Institut Català de la Salut, Santa Coloma de Gramenet, Barcelona, Spain.|Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Valverde
authors.affiliation: Research Unit Barcelonès Nord Maresme, ICS-IDIAP Jordi Gol, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Muñoz
authors.affiliation: Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain.|Research Unit Barcelona, ICS-IDIAP Jordi Gol, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Mundet
authors.affiliation: Research Unit Barcelonès Nord Maresme, ICS-IDIAP Jordi Gol, Barcelona, Spain.
authors.forename: Pere
authors.initials: P
authors.lastname: Torán
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D015999:Multivariate Analysis; D058729:Peripheral Arterial Disease / Q000453:epidemiology* / Q000503:physiopathology; D016016:Proportional Hazards Models; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology*; D013030:Spain / Q000453:epidemiology
chemical_list: D008076:Cholesterol, HDL