title: Synthesis, self-assembly, and in vitro toxicity of fatty acids-modified Bletilla striata polysaccharide.
abstract: Hydrophobic modification of Bletilla striata polysaccharide (BSP) was performed by grafting fatty acids to BSP backbone and then characterized on their physicochemical properties. All neutral derivatives were able to self-assemble into spherical particles within the size range of 250-400 nm, their size and critical micelle concentration decreased with increasing hydrophobicity and substitution degree of the fatty acids. Also, the BSP-stearic acid conjugates showed a preferable performance on hemolysis test and cytotoxicity analysis on HepG2 cells, which suggested their potential application as a drug delivery vector.
authors.affiliation: a School of Pharmacy, Ningxia Medical University , Yinchuan , Ningxia , China.
authors.forename: Wenping
authors.initials: W
authors.lastname: Wang
authors.affiliation: a School of Pharmacy, Ningxia Medical University , Yinchuan , Ningxia , China.
authors.forename: Shaolong
authors.initials: S
authors.lastname: He
authors.affiliation: b Department of Pharmacy , General Hospital of Yan Kuang Group , Zou Cheng , Shandong , China.
authors.forename: Tongtong
authors.initials: T
authors.lastname: Hong
authors.affiliation: c School of Basic Medicine, Ningxia Medical University , Yinchuan , Ningxia , China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a School of Pharmacy, Ningxia Medical University , Yinchuan , Ningxia , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Sui
authors.affiliation: a School of Pharmacy, Ningxia Medical University , Yinchuan , Ningxia , China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: d General Hospital of Ningxia Medical University , Yinchuan , Ningxia , China.
authors.forename: Yanni
authors.initials: Y
authors.lastname: Ma
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems / Q000009:adverse effects / Q000379:methods; D056945:Hep G2 Cells; D006801:Humans; D011134:Polysaccharides / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D013229:Stearic Acids / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology
chemical_list: D011134:Polysaccharides; D013229:Stearic Acids; C000591471:polysaccharide b, Bletilla striata; C031183:stearic acid
keywords: Bletilla striata; HepG2 cells; glucomannan; hemolysis; hydrophobic modification; nanoparticles