title: [Isolated factor X deficiency in chronic myelomonocytic leukemia: Report of one case].
abstract: Bleeding disorders are commonly associated with hemato-oncologic diseases. We report a 68 years old male with a chronic myelomonocytic leukemia derived from a long lasting mielodysplastic syndrome that did not respond to treatment with Azacitidine. The patient was hospitalized due to tonic clonic seizures. A CAT scan showed a hematoma in the frontal lobe. A new assessment of hemostasis revealed an isolated deficiency of Factor X. We speculate that this deficit could be secondary to consumption due to the chronic Myelomonocytic Leukemia.
authors.forename: Javier
authors.initials: J
authors.lastname: Zelada
authors.forename: Gabriela
authors.initials: G
authors.lastname: Cantó
authors.forename: Alejandro
authors.initials: A
authors.lastname: Berkovits
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Diocares
authors.forename: Adriana
authors.initials: A
authors.lastname: López
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001374:Azacitidine / Q000627:therapeutic use; D005171:Factor X Deficiency / Q000175:diagnosis / Q000209:etiology*; D005625:Frontal Lobe / Q000293:injuries*; D006406:Hematoma / Q000175:diagnosis; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications* / Q000188:drug therapy; D007962:Leukocytes; D008297:Male; D009000:Monocytes; D012640:Seizures / Q000150:complications
chemical_list: D000964:Antimetabolites, Antineoplastic; D001374:Azacitidine