title: Novel insights into human respiratory syncytial virus-host factor interactions through integrated proteomics and transcriptomics analysis.
abstract: The lack of vaccine and limited antiviral options against respiratory syncytial virus (RSV) highlights the need for novel therapeutic strategies. One alternative is to develop drugs that target host factors required for viral replication. Several microarray and proteomics studies had been published to identify possible host factors that are affected during RSV replication. In order to obtain a comprehensive understanding of RSV-host interaction, we integrated available proteome and transcriptome datasets and used it to construct a virus-host interaction network. Then, we interrogated the network to identify host factors that are targeted by the virus and we searched for drugs from the DrugBank database that interact with these host factors, which may have potential applications in repositioning for future treatment options of RSV infection.
authors.affiliation: a Department of Virology , Tohoku University Graduate School of Medicine , Sendai , Miyagi Prefecture , Japan.
authors.forename: Clyde
authors.initials: C
authors.lastname: Dapat
authors.affiliation: a Department of Virology , Tohoku University Graduate School of Medicine , Sendai , Miyagi Prefecture , Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Oshitani
mesh_terms: D020869:Gene Expression Profiling; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D046228:Microarray Analysis; D040901:Proteomics; D018357:Respiratory Syncytial Virus Infections / Q000235:genetics*; D018113:Respiratory Syncytial Virus, Human / Q000502:physiology
keywords: Drug-drug target interaction network; Microarray analysis; Protein-protein interaction network; Proteomics; Respiratory syncytial virus; Virus-host interactions; human