title: Association of monocyte/HDL-C ratio with SYNTAX scores in patients with stable coronary artery disease.
abstract: OBJECTIVE
  The aim of this study was to investigate the relationship between monocyte count/high density lipoprotein cholesterol (HDL-C) ratio (MHR) and the severity of coronary atherosclerosis, as assessed by the SYNTAX score (SXscore), in patients with stable coronary artery disease (CAD) undergoing coronary angiography.
  
  
  METHODS
  A total of 428 patients were included in the study between March 2012 and February 2015. The SXscore was determined with baseline coronary angiography. An SXscore ≥ 23 was regarded as severe CAD by definition, and the patients were divided into two groups: those with low SXscores (< 23) and those with high SXscores (≥ 23).
  
  
  RESULTS
  MHR and C-reactive protein (CRP) were significantly higher in patients with high SXscores (p < 0.001 and p < 0.001, respectively). Left ventricular ejection fraction (LVEF) was lower in the group with high MHR and high SXscores. The cutoff value of MHR that predicted a high SXscore was 24, with a sensitivity of 66 % and a specificity of 65.1 %.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first study in the literature showing that MHR is significantly associated with SXscores. Our results suggest that MHR can be used as a prognostic marker in patients with stable CAD, since it is an easily available and inexpensive test.
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey. harunkundi@hotmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Kundi
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Kiziltunc
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Cetin
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Cicekcioglu
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Cetin
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Cicek
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Ornek
mesh_terms: D060050:Angina, Stable / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL
keywords: Atherogenesis; Cholesterol; Echocardiography; Inflammation; Plaque, atherosclerotic