title: Clinical characteristics of patients with Rutherford category IV, compared with V and VI.
abstract: OBJECTIVE
  Patients categorized Rutherford category IV might have different characteristics compared with Rutherford category V and VI. Our study aims were to estimate the clinical differences between Rutherford category IV and Rutherford category V and VI, for those underwent endovascular therapy for isolated infrapopliteal disease, and also to find risk factors for endovascular therapy in Rutherford category IV.
  
  
  METHODS
  Based on the Japanese multi-center registry data, 1091 patients with 1332 limbs (Rutherford category IV: 226 patients with 315 limbs, Rutherford category V and VI: 865 patients with 1017 limbs) were analyzed retrospectively.
  
  
  RESULTS
  Patients' backgrounds and lesions' characteristics had significant differences. Both freedom rate from major adverse limb event with perioperative death and amputation-free survival rate at 1 year were better in Rutherford category IV than Rutherford category V and VI (93.6% vs 78.3%, 87.7% vs 66.7%) and those maintained to 3 years (p < 0.0001). Significant predictors for major adverse limb event/perioperative death were small body mass index (<18.5 kg/m(3)) and initial endovascular therapy success, and those for amputation-free survival were small body mass index (<18.5 kg/m(3)), non-ambulatory status, high systematic inflammatory reaction (C-reactive protein > 3.0 mg/dL), chronic obstructive pulmonary disease, and coronary artery disease in Rutherford category IV.
  
  
  CONCLUSIONS
  From the present results, Rutherford category IV should be recognized to have quite different backgrounds and better outcome from Rutherford category V and VI.
authors.affiliation: Division of Trans-catheter Cardiovascular Therapeutics, Kanazawa Medical University Hospital, Kahoku, Japan.
authors.forename: Taketsugu
authors.initials: T
authors.lastname: Tsuchiya
authors.affiliation: Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Iida
authors.affiliation: Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Shiraki
authors.affiliation: Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Soga
authors.affiliation: Division of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Yokohama, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hirano
authors.affiliation: Department of Cardiology, Sendai Kousei Hospital, Sendai, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Vascular Surgery, Matsuyama Red Cross Hospital, Matsuyama, Japan.
authors.forename: Terutoshi
authors.initials: T
authors.lastname: Yamaoka
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Miyashita
authors.affiliation: Division of Trans-catheter Cardiovascular Therapeutics, Kanazawa Medical University Hospital, Kahoku, Japan.
authors.forename: Michihiko
authors.initials: M
authors.lastname: Kitayama
authors.affiliation: Division of Cardiology, Kanazawa Medical University Hospital, Kahoku, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Kajinami
keywords: Critical limb ischemia; endovascular therapy; multivariate analysis