title: Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis.
abstract: OBJECTIVE
  The relationship between SIRT1 and clinicopathological parameters of colorectal cancer (CRC) is controversial. To evaluate the clinicopathological and prognostic value of silent mating type information regulation 2 homolog-1 (SIRT1) expressions in patients with CRC, a meta-analysis was performed.
  
  
  METHODS
  We conducted a meta-analysis to investigate the impact of SIRT1 on clinicopathological parameters and prognosis in CRC patients. Studies assessing the relationship between these parameters and SIRT1 expression in CRC were identified up to September, 2015.
  
  
  RESULTS
  Seven studies met the inclusion criteria. Our results showed that SIRT1 expression was correlated with depth of invasion (OR = 0.922, 95% CI: 0.646-1.316, P = 0.005), lymph node metastasis (OR = 1.001, 95% CI: 0.781-1.283, P = 0.000) and TNM stage (OR = 1.103, 95% CI: 0.892-1.365, P = 0.008). Furthermore, we found that SIRT1 expression predicted a poor overall survival (OS) in CRC patients (OR = 1.220, 95% CI: 0.955-1.558, P = 0.037, fixed-effect).
  
  
  CONCLUSIONS
  The overall data of the present meta-analysis showed that SIRT1 expression was not correlated with clinicopathological features except for depth of invasion, lymph node metastasis and TNM stage. Simultaneously, SIRT1 overexpression predicted a poor OS in CRC patients, and SIRT1 is a candidate negative prognostic biomarker for CRC patients.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian Shahekou District Zhongshan Road No. 467, Dalian 116027, China. Electronic address: zushanghai@163.com.
authors.forename: Guo
authors.initials: G
authors.lastname: Zu
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian Shahekou District Zhongshan Road No. 467, Dalian 116027, China.
authors.forename: Anlong
authors.initials: A
authors.lastname: Ji
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address: jane1987@126.com.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China.
authors.forename: Ningwei
authors.initials: N
authors.lastname: Che
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D056564:Sirtuin 1 / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Clinicopathological characteristics; Colorectal cancer; Prognosis; SIRT1