title: Effect of Hesperidin With and Without a Calcium (Calcilock) Supplement on Bone Health in Postmenopausal Women.
abstract: BACKGROUND
  Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats.
  
  
  OBJECTIVE
  The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women.
  
  
  METHODS
  The study was a double-blind, placebo-controlled, randomized-order crossover design of 500 g hesperidin with or without 500 mg calcium supplement in 12 healthy postmenopausal women. Bone calcium retention was determined from urinary excretion of the rare isotope, (41)Ca, from bone.
  
  
  RESULTS
  Calcium plus hesperidin, but not hesperidin alone, improved bone calcium retention by 5.5% (P < .04).
  
  
  CONCLUSIONS
  Calcium supplementation (Calcilock), in combination with hesperidin, is effective at preserving bone in postmenopausal women.
authors.affiliation: Departments of Nutrition Science (B.R.M., L.M., C.M.W.), Statistics (G.P.M.), and Physics (G.S.J.), Purdue University, West Lafayette, Indiana 47907-2059; Nestle Research Center (M.N.H., E.O.-C.), 1000 Lausanne, Switzerland; and Indiana University School of Medicine (M.P.), Indianapolis, Indiana 46202.
authors.forename: Berdine R
authors.initials: BR
authors.lastname: Martin
authors.affiliation: Departments of Nutrition Science (B.R.M., L.M., C.M.W.), Statistics (G.P.M.), and Physics (G.S.J.), Purdue University, West Lafayette, Indiana 47907-2059; Nestle Research Center (M.N.H., E.O.-C.), 1000 Lausanne, Switzerland; and Indiana University School of Medicine (M.P.), Indianapolis, Indiana 46202.
authors.forename: George P
authors.initials: GP
authors.lastname: McCabe
authors.affiliation: Departments of Nutrition Science (B.R.M., L.M., C.M.W.), Statistics (G.P.M.), and Physics (G.S.J.), Purdue University, West Lafayette, Indiana 47907-2059; Nestle Research Center (M.N.H., E.O.-C.), 1000 Lausanne, Switzerland; and Indiana University School of Medicine (M.P.), Indianapolis, Indiana 46202.
authors.forename: Linda
authors.initials: L
authors.lastname: McCabe
authors.affiliation: Departments of Nutrition Science (B.R.M., L.M., C.M.W.), Statistics (G.P.M.), and Physics (G.S.J.), Purdue University, West Lafayette, Indiana 47907-2059; Nestle Research Center (M.N.H., E.O.-C.), 1000 Lausanne, Switzerland; and Indiana University School of Medicine (M.P.), Indianapolis, Indiana 46202.
authors.forename: George S
authors.initials: GS
authors.lastname: Jackson
authors.affiliation: Departments of Nutrition Science (B.R.M., L.M., C.M.W.), Statistics (G.P.M.), and Physics (G.S.J.), Purdue University, West Lafayette, Indiana 47907-2059; Nestle Research Center (M.N.H., E.O.-C.), 1000 Lausanne, Switzerland; and Indiana University School of Medicine (M.P.), Indianapolis, Indiana 46202.
authors.forename: Marie Noelle
authors.initials: MN
authors.lastname: Horcajada
authors.affiliation: Departments of Nutrition Science (B.R.M., L.M., C.M.W.), Statistics (G.P.M.), and Physics (G.S.J.), Purdue University, West Lafayette, Indiana 47907-2059; Nestle Research Center (M.N.H., E.O.-C.), 1000 Lausanne, Switzerland; and Indiana University School of Medicine (M.P.), Indianapolis, Indiana 46202.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Offord-Cavin
authors.affiliation: Departments of Nutrition Science (B.R.M., L.M., C.M.W.), Statistics (G.P.M.), and Physics (G.S.J.), Purdue University, West Lafayette, Indiana 47907-2059; Nestle Research Center (M.N.H., E.O.-C.), 1000 Lausanne, Switzerland; and Indiana University School of Medicine (M.P.), Indianapolis, Indiana 46202.
authors.forename: Munro
authors.initials: M
authors.lastname: Peacock
authors.affiliation: Departments of Nutrition Science (B.R.M., L.M., C.M.W.), Statistics (G.P.M.), and Physics (G.S.J.), Purdue University, West Lafayette, Indiana 47907-2059; Nestle Research Center (M.N.H., E.O.-C.), 1000 Lausanne, Switzerland; and Indiana University School of Medicine (M.P.), Indianapolis, Indiana 46202.
authors.forename: Connie M
authors.initials: CM
authors.lastname: Weaver
mesh_terms: D000368:Aged; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes / Q000652:urine; D002136:Calcium, Dietary / Q000008:administration & dosage*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006569:Hesperidin / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D010919:Placebos; D017698:Postmenopause
chemical_list: D002132:Calcium Radioisotopes; D002136:Calcium, Dietary; D010919:Placebos; D006569:Hesperidin; D002118:Calcium