title: Anti-Inflammatory Activity of Tanzawaic Acid Derivatives from a Marine-Derived Fungus Penicillium steckii 108YD142.
abstract: Chemical investigation of a marine-derived fungus, Penicillium steckii 108YD142, resulted in the discovery of a new tanzawaic acid derivative, tanzawaic acid Q (1), together with four known analogues, tanzawaic acids A (2), C (3), D (4), and K (5). The structures of tanzawaic acid derivatives 1-5 were determined by the detailed analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis. These compounds significantly inhibited nitric oxide (NO) production and the new tanzawaic acid Q (1) inhibited the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins and mRNA expressions in RAW 264.7 macrophages. Additionally, compound 1 reduced the mRNA levels of inflammatory cytokines. Taken together, the results of this study demonstrated that the new tanzawaic acid derivative inhibits LPS-induced inflammation. This is the first report on the anti-inflammatory activity of tanzawaic acid Q (1).
authors.affiliation: Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea. shinhj@kiost.ac.
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Shin
authors.affiliation: Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea. vlfrkaqkd@kiost.ac.|Department of Applied Chemistry, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-ku, Ansan, Gyeongi-do 15588, Korea. vlfrkaqkd@kiost.ac.
authors.forename: Gam Bang
authors.initials: GB
authors.lastname: Pil
authors.affiliation: Jeju International Marine Science Center for Research &amp; Education, Korea Institute of Ocean Science and Technology, Jeju 63349, Korea. sjheo@kiost.ac.kr.
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Heo
authors.affiliation: Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea. hslee@kiost.ac.
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea. jslee@kiost.ac.
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea. yjlee@kiost.ac.
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea. jihoonlee@kiost.ac.
authors.forename: Jihoon
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Applied Chemistry, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-ku, Ansan, Gyeongi-do 15588, Korea. hswon@hanyang.ac.kr.
authors.forename: Ho Shik
authors.initials: HS
authors.lastname: Won
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D051546:Cyclooxygenase 2 / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009284:Naphthols / Q000737:chemistry / Q000494:pharmacology*; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects; D010407:Penicillium; D012623:Seawater; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D005231:Fatty Acids, Unsaturated; D009284:Naphthols; C000611218:tanzawaic acid Q; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2
keywords: Penicillium steckii; anti-inflammatory; marine fungus; tanzawaic acids