title: Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults.
abstract: Gender-related differences in the association between polymorphism of xenobiotic-metabolising enzymes or non-genetic biomarkers and susceptibility to oxidative stress was assessed in healthy middle-aged Serbian adults, by urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG/creatinine) and total antioxidant status in serum (TAOS). Females were more susceptible to oxidative stress. In both genders, positive predictor of the antioxidative protection was serum triglyceride, while BMI <25 kg/m(2) was associated with oxidative stress. Susceptibility to oxidative stress in males was associated with GSTT1*null allele and increased serum iron, but in females, it was decreased serum bilirubin. Early identification of the risk factors could be important in the prevention of oxidative stress-related diseases.
authors.affiliation: a Department of Medical Biochemistry , Faculty of Pharmacy, University of Belgrade , Belgrade , Serbia .
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Topic
authors.affiliation: b Faculty of Pharmacy , University of Bijeljina , Bijeljina , Bosnia & Herzegovina .
authors.forename: Zivka
authors.initials: Z
authors.lastname: Malic
authors.affiliation: c Institute of Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia .
authors.forename: Djordje
authors.initials: D
authors.lastname: Francuski
authors.affiliation: c Institute of Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia .
authors.forename: Marija
authors.initials: M
authors.lastname: Stankovic
authors.affiliation: d Department of Pharmaceutical Chemistry , Faculty of Pharmacy, University of Belgrade , Belgrade , Serbia .
authors.forename: Bojan
authors.initials: B
authors.lastname: Markovic
authors.affiliation: c Institute of Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia .
authors.forename: Blagoje
authors.initials: B
authors.lastname: Soskic
authors.affiliation: c Institute of Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia .
authors.forename: Branko
authors.initials: B
authors.lastname: Tomic
authors.affiliation: c Institute of Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia .
authors.forename: Stefan
authors.initials: S
authors.lastname: Ilic
authors.affiliation: e Clinical Chemical Laboratory, Health Centre , "Stari Grad", Belgrade , Serbia , and.
authors.forename: Snezana
authors.initials: S
authors.lastname: Dobrivojevic
authors.affiliation: f Clinical Chemical Laboratory, General Hospital , Pancevo , Serbia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Drca
authors.affiliation: c Institute of Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia .
authors.forename: Dragica
authors.initials: D
authors.lastname: Radojkovic
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000483:Alleles; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000652:urine; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004851:Epoxide Hydrolases / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D055771:Serbia; D012737:Sex Factors
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000975:Antioxidants; D015415:Biomarkers; D003404:Creatinine; D019363:Cytochrome P-450 CYP1A1; D003849:Deoxyguanosine; D004851:Epoxide Hydrolases; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D007501:Iron; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human
keywords: Cytochrome P450 1A1; glutathione-S-transferase; microsomal epoxide hydrolase; oxidative stress