title: Approach to the sonographic evaluation of fetal ventriculomegaly at 11 to 14 weeks gestation.
abstract: BACKGROUND
  The aim of the study was to report the prevalence and associated findings of fetal ventriculomegaly between 11 + 0 and 13 + 6 gestational weeks and to evaluate a sonographic approach to classify first trimester ventriculomegaly in the standard axial plane used for biparietal diameter (BPD) measurement.
  
  
  METHODS
  The ratio between choroid plexus and lateral ventricle diameter (PDVDR), between the choroid plexus and lateral ventricle length (PLVLR) and between the choroid plexus and lateral ventricle area (PAVAR) were calculated from stored 2D images of the axial head plane in 100 normal fetuses and 17 fetuses with ventriculomegaly.
  
  
  RESULTS
  The PDVDR, the PLVLR and the PAVAR were below the 5(th) percentile in 82.4%, 94.1% and 94.1% of the cases with ventriculomegaly. Ventriculomegaly was isolated in 29.4% and associated with further anomalies in 70.6% at the initial evaluation. The mean PLVLR in euploid compared to aneuploid fetuses was significantly lower (0.40 versus 0.53 (p = 0.0332)).
  
  
  CONCLUSIONS
  The measurements of PDVDR, PLVLR and PAVAR are helpful to objectify ventriculomegaly at 11-14 gestational weeks. The PLVLR and PAVAR were superior to PDVDR, since there seems to be rather shrinkage of the choroid plexus than an increased width of the lateral ventricles in the first trimester.
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany. gwendolin.manegold-brauer@usb.ch.|Department of Prenatal Medicine and Gynecologic Ultrasound, University of Basel, Basel, Switzerland. gwendolin.manegold-brauer@usb.ch.
authors.forename: Gwendolin
authors.initials: G
authors.lastname: Manegold-Brauer
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany. anton.oseledchyk@ukb.uni-bonn.de.
authors.forename: Anton
authors.initials: A
authors.lastname: Oseledchyk
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany. anne.floeck@ukb.uni-bonn.de.
authors.forename: Anne
authors.initials: A
authors.lastname: Floeck
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany. christoph.berg@ukb.uni-bonn.de.|Department of Obstetrics and Gynecology, Division of Prenatal Medicine and Gynecologic Ultrasound, University of Cologne, Cologne, Germany. christoph.berg@ukb.uni-bonn.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Berg
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany. ulrich.gembruch@ukb.uni-bonn.de.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Gembruch
authors.affiliation: Department of Obstetrics and Prenatal Medicine, University of Bonn, Sigmund-Freud-Str. 25, Bonn, Germany. annegret.geipel@ukb.uni-bonn.de.
authors.forename: Annegret
authors.initials: A
authors.lastname: Geipel
mesh_terms: D002831:Choroid Plexus / Q000000981:diagnostic imaging / Q000196:embryology; D005260:Female; D005865:Gestational Age; D006257:Head / Q000000981:diagnostic imaging / Q000196:embryology; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging*; D020547:Lateral Ventricles / Q000000981:diagnostic imaging / Q000196:embryology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D016216:Ultrasonography, Prenatal / Q000379:methods*