title: The Influence on LPS-Induced ROS Formation in Macrophages of Capelloside A, a New Steroid Glycoside from the Starfish Ogmaster capella.
abstract: A new steroid glycoside, capelloside A (1), was isolated from the ethanolic extract of the startish Ugmaster capella along with the previously known coscinasteroside B (2). The structures of 1 was elucidated by extensive NMR and ESI-MS techniques as (24S)-24-O-(3-O-methyl-β-D-xylopyranosyl)-5a- cholestane-3β,6β,8,15α,24-pentoI 15-O-sulfate (1). Compounds 1 and 2 decreased intracellular ROS (reactive oxygen species) levels in murine macrophages of the RAW 264.7 cell line at induction by endotoxic lipopolysaccharide (LPS) from E. coli by 60% and 41%, correspondingly.
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Ivanchina
authors.forename: Alla A
authors.initials: AA
authors.lastname: Kicha
authors.forename: Timofey V
authors.initials: TV
authors.lastname: Malyarenko
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Kalinovsky
authors.forename: Ekaterina S
authors.initials: ES
authors.lastname: Menchinskaya
authors.forename: Evgeny A
authors.initials: EA
authors.lastname: Pislyagin
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
mesh_terms: D000818:Animals; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000009:adverse effects; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D000067996:RAW 264.7 Cells; D017382:Reactive Oxygen Species / Q000378:metabolism; D013215:Starfish / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D006027:Glycosides; D008070:Lipopolysaccharides; D017382:Reactive Oxygen Species; D013256:Steroids