title: Meta-analysis of association of the matrix metalloproteinase 2 (-735 C/T) polymorphism with cancer risk.
abstract: The association between matrix metalloproteinase 2 (MMP2) gene polymorphisms and cancer risk has been investigated in many published studies; however, the currently available results are inconclusive. Therefore, we performed a meta-analysis to provide conclusive evidence for an association between the MMP2 polymorphism (-735 C/T) and cancer risk. Sixteen case-control studies with 11792 individuals were included in this meta-analysis. The odds ratio (OR) and 95% confidence interval (95% CI) were used to investigate the strength of the association. Overall, the MMP2 polymorphism (-735 C/T) was not associated with cancer risk in any of the models. However, the subgroup analysis revealed that dominant model (C/T+T/T vs. C/C: OR=1.24, 95% CI=1.01-1.53) and codominant 1 model (C/T vs. C/C: OR=1.30, 95% CI=1.05-1.62) were significantly associated with cancer risk in the Caucasian population. In conclusion, our meta-analysis indicated that the MMP2 polymorphism (-735 C/T) might be genetic risk factor for the carcinogenesis in Caucasians. However, more studies with a larger sample size are needed to provide more precise evidence.
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University Seoul, Republic of Korea.
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University Seoul, Republic of Korea.
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Kang
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University Seoul, Republic of Korea.
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Department of Medical Laser, Dankook University Graduate School, Cheonan, Republic of Korea.
authors.forename: Ju Yeon
authors.initials: JY
authors.lastname: Ban
authors.affiliation: Department of Medical Laser, Dankook University Graduate School, Cheonan, Republic of Korea.
authors.forename: Chung-Hun
authors.initials: CH
authors.lastname: Oh
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University Seoul, Republic of Korea.
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University Seoul, Republic of Korea.
authors.forename: In-Hwan
authors.initials: IH
authors.lastname: Oh
authors.affiliation: Department of Biomedical Laboratory Science, College of Health Sciences, Shinhan University Gyeonggi, Republic of Korea.
authors.forename: Kyu Bong
authors.initials: KB
authors.lastname: Cho
authors.affiliation: Department of Surgery, School of Medicine, Kyung Hee University Seoul, Republic of Korea.
authors.forename: Min-Su
authors.initials: MS
authors.lastname: Park
keywords: Matrix metalloproteinase 2; cancer; meta-analysis; polymorphism