title: Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury.
abstract: Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse involving the interaction of cell injury in hepatocytes, immune cells, and endothelium, mitochondrial dysfunction is a cardinal event culminating in hepatic reperfusion injury. Mitochondrial autophagy, so-called mitophagy, is a key cellular process that regulates mitochondrial homeostasis and eliminates damaged mitochondria in a timely manner. Growing evidence accumulates that I/R injury is attributed to defective mitophagy. This review aims to summarize the current understanding of autophagy and its role in hepatic I/R injury and highlight the various therapeutic approaches that have been studied to ameliorate injury.
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Kristina L
authors.initials: KL
authors.lastname: Go
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Sooyeon
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Zendejas
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Behrns
authors.affiliation: Department of Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D001343:Autophagy; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology*; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology; D063306:Mitophagy; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology*