title: Ovarian Tissue Cryopreservation for Benign Gynecologic Disease: A Case of Ovarian Torsion and Review of the Literature.
abstract: Ovarian tissue cryopreservation (OTC) is an emerging method for fertility preservation. Although OTC has been previously proposed for benign indications, to our knowledge this is the first report highlighting the use of OTC for the indication of ovarian torsion. A 36-year-old nulligravid woman with a history of recurrent ovarian torsion presented with an acute episode of ovarian torsion confirmed by ultrasound. She requested a laparoscopic oophorectomy because her previous oophoropexy had failed, and in light of this was counseled to undergo concurrent OTC. On laparoscopy, 10 strips of ovarian cortex were obtained. A portion of this tissue was sent for pathological analysis, which revealed a primordial follicle density of 167 follicles/mm(3), a primary follicle density of 38 follicles/mm(3), and minimal ischemic damage. Although the clinical application of OTC continues to evolve and requires further investigation, the possibility of expanding the indications for benign gynecologic conditions is promising.
authors.affiliation: Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address: hickmal@ccf.org.
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Hickman
authors.affiliation: Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio.
authors.forename: Mary Jean
authors.initials: MJ
authors.lastname: Uy-Kroh
authors.affiliation: Department of Pathology, Cleveland Clinic Foundation, Cleveland, Ohio.
authors.forename: Andres
authors.initials: A
authors.lastname: Chiesa-Vottero
authors.affiliation: Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio.
authors.forename: Nina
authors.initials: N
authors.lastname: Desai
authors.affiliation: Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Flyckt
mesh_terms: D000328:Adult; D015925:Cryopreservation / Q000379:methods; D005184:Fallopian Tube Diseases / Q000601:surgery*; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D010049:Ovarian Diseases / Q000601:surgery*; D006080:Ovarian Follicle / Q000473:pathology*; D010052:Ovariectomy; D014102:Torsion Abnormality / Q000601:surgery*; D016896:Treatment Outcome
keywords: Fertility preservation; Ovarian tissue cryopreservation; Ovarian torsion