title: Benefits of Physical Exercise for Individuals with Fragile X Syndrome in Humans.
abstract: Fragile X syndrome (FXS) is the most common known genetic cause of autism spectrum disorder, and is also linked to other neurologic and psychiatric disorders. The purpose of this review article is to examine a variety of recent studies on the correlation between physical exercise and autistic behavior in individuals with fragile X syndrome. Additionally, we discuss promising approaches for further investigation of the benefits of physical exercise for autism spectrum disorder (ASD) patients. A systematic search of the PubMed digital library database for pertinent articles published from 1995 to 2011 was conducted. Individuals with ASD who experience exercise tend to exhibit improvement in physical function. In addition, exercise promotes neurotrophic factors and boosts the growth of new brain cells. The collected review articles describe how physical exercise has particular effects on stereotypic behavior and cognition among ASD patients. Finally, physical exercise may benefit patients with autism spectrum disorder through the improvement of muscular strength for increased physical capability.
authors.affiliation: Department of Rehabilitation Science, Graduate School, Inje University, Gimhae, Korea; Ubiquitous Healthcare & Anti-aging Research Center (u-HARC), Inje University, Gimhae, Korea; Biohealth Products Research Center (BPRC), Inje University, Gimhae, Korea.
authors.forename: Minkyung
authors.initials: M
authors.lastname: Lee
authors.affiliation: Department of Rehabilitation Science, Graduate School, Inje University, Gimhae, Korea; Ubiquitous Healthcare & Anti-aging Research Center (u-HARC), Inje University, Gimhae, Korea; Biohealth Products Research Center (BPRC), Inje University, Gimhae, Korea.
authors.forename: Jinyoung
authors.initials: J
authors.lastname: Won
authors.affiliation: Ubiquitous Healthcare & Anti-aging Research Center (u-HARC), Inje University, Gimhae, Korea; Biohealth Products Research Center (BPRC), Inje University, Gimhae, Korea; Department of Physical Therapy, College of Biomedical Science & Engineering, Inje University, Gimhae, Korea.
authors.forename: Seonghoon
authors.initials: S
authors.lastname: Lee
authors.affiliation: Ubiquitous Healthcare & Anti-aging Research Center (u-HARC), Inje University, Gimhae, Korea; Biohealth Products Research Center (BPRC), Inje University, Gimhae, Korea; Department of Physical Therapy, College of Biomedical Science & Engineering, Inje University, Gimhae, Korea.
authors.forename: Yunkyung
authors.initials: Y
authors.lastname: Hong
authors.affiliation: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Korea.
authors.forename: Joo-Heon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Rehabilitation Science, Graduate School, Inje University, Gimhae, Korea; Ubiquitous Healthcare & Anti-aging Research Center (u-HARC), Inje University, Gimhae, Korea; Biohealth Products Research Center (BPRC), Inje University, Gimhae, Korea; Department of Physical Therapy, College of Biomedical Science & Engineering, Inje University, Gimhae, Korea.
authors.forename: Yonggeun
authors.initials: Y
authors.lastname: Hong
keywords: Autism spectrum disorders; Fragile X syndrome; Physical exercise