title: Ethical considerations in the conduct of research on therapies for the prevention and treatment of Ebola virus disease in developing countries.
abstract: The devastating toll of the Ebola epidemic in West Africa necessitates considerations of new approaches to research into new prevention technologies and treatments for Ebola Virus Disease (EVD). Research must be planned and delivered in consultation with civil society from the epicentre to prevent mistrust and misunderstanding. Ethical considerations include development of local research and regulatory capacity; negotiating the standard of prevention packages for research participants, including healthcare workers; and strengthening health systems in developing countries to ensure effective response to future EVD outbreaks in the region. Also, strategic consultation with local communities is an ethical imperative for EVD research, particularly where there is potential for differential access to prevention and care packages between trial staff and local hospital staff.
authors.affiliation: Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria A234.
authors.forename: Morenike Oluwatoyin
authors.initials: MO
authors.lastname: Folayan
authors.affiliation: Bridget Gabrielle Haire, Kirby Institute for Infection and Immunity in Society, Wallace Wurth Building, UNSW Australia, Sydney, NSW 2052, Australia.
authors.forename: Bridget Gabrielle
authors.initials: BG
authors.lastname: Haire
mesh_terms: D000354:Africa, Western / Q000453:epidemiology; D035843:Biomedical Research / Q000941:ethics / Q000458:organization & administration*; D003906:Developing Countries; D004196:Disease Outbreaks / Q000517:prevention & control*; D032984:Ethics, Research; D006282:Health Personnel / Q000458:organization & administration; D006297:Health Services Accessibility; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000517:prevention & control* / Q000628:therapy; D006801:Humans
keywords: Ebola; Ethics; developing countries; research