title: The Structure-Activity Relationship of the Antioxidant Peptides from Natural Proteins.
abstract: Peptides derived from dietary proteins, have been reported to display significant antioxidant activity, which may exert notably beneficial effects in promoting human health and in food processing. Recently, much research has focused on the generation, separation, purification and identification of novel peptides from various protein sources. Some researchers have tried to discover the structural characteristics of antioxidant peptides in order to lessen or avoid the tedious and aimless work involving the ongoing generated peptide preparation schemes. This review aims to summarize the current knowledge on the relationship between the structural features of peptides and their antioxidant activities. The relationship between the structure of the precursor proteins and their abilities to release antioxidant fragments will also be summarized and inferred. The preparation methods and antioxidant capacity evaluation assays of peptides and a prediction scheme of quantitative structure-activity relationship (QSAR) will also be pointed out and discussed.
authors.affiliation: Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. zoutb@163.com.
authors.forename: Tang-Bin
authors.initials: TB
authors.lastname: Zou
authors.affiliation: Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. taipinghe@163.com.
authors.forename: Tai-Ping
authors.initials: TP
authors.lastname: He
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. lihuabin@mail.sysu.edu.cn.
authors.forename: Hua-Bin
authors.initials: HB
authors.lastname: Li
authors.affiliation: Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. gdmcthw@126.com.
authors.forename: Huan-Wen
authors.initials: HW
authors.lastname: Tang
authors.affiliation: Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. enqinxia@163.com.
authors.forename: En-Qin
authors.initials: EQ
authors.lastname: Xia
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D001688:Biological Products / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D059748:Proteolysis; D021281:Quantitative Structure-Activity Relationship; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D055672:Static Electricity
chemical_list: D000596:Amino Acids; D000975:Antioxidants; D001688:Biological Products; D004044:Dietary Proteins; D010446:Peptide Fragments; D017382:Reactive Oxygen Species
keywords: antioxidant peptides; proteins; structure-activity relationship