title: Expression of FGFs during early mouse tongue development.
abstract: The fibroblast growth factors (FGFs) constitute one of the largest growth factor families, and several ligands and receptors in this family are known to play critical roles during tongue development. In order to provide a comprehensive foundation for research into the role of FGFs during the process of tongue formation, we measured the transcript levels by quantitative PCR and mapped the expression patterns by in situ hybridization of all 22 Fgfs during mouse tongue development between embryonic days (E) 11.5 and E14.5. During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme. Our results indicate that FGF signaling regulates tongue development at multiple stages.
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Wen
authors.initials: W
authors.lastname: Du
authors.affiliation: Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA 94143, USA; Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Prochazka
authors.affiliation: Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA 94143, USA; Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague, Czech Republic.
authors.forename: Michaela
authors.initials: M
authors.lastname: Prochazkova
authors.affiliation: Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics and Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address: ophir.klein@ucsf.edu.
authors.forename: Ophir D
authors.initials: OD
authors.lastname: Klein
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics*; D004848:Epithelium / Q000254:growth & development / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D017403:In Situ Hybridization; D008648:Mesoderm / Q000254:growth & development / Q000378:metabolism; D051379:Mice; D038081:Organogenesis / Q000235:genetics; D015398:Signal Transduction; D014059:Tongue / Q000254:growth & development* / Q000378:metabolism
chemical_list: D005346:Fibroblast Growth Factors
keywords: Expression; FGF; Papilla; Tongue