title: Analysis of the correlative factors in the selection of interbody fusion cage height in transforaminal lumbar interbody fusion.
abstract: BACKGROUND
  Selecting an interbody cage with appropriate height is one of the key steps in lumbar interbody fusion, and has an important impact on clinical efficacy. How to choose the appropriate height of the cage becomes one of the core problems of lumbar interbody fusion for spine surgeons. However, studies about objective selection criteria on interbody cage height was rare.
  
  
  METHODS
  One hundred fifty-seven patients with single segment lumbar degenerative diseases treated by TLIF surgery from January 2011 to July 2013 were retrospectively analyzed. Parameters analyzed included: gender, age, body height, clinical diagnosis, pathological segment location and the intervertebral height of pathological segment, pathological segment activity, the intervertebral height of the adjacent segments. And further to analyze the correlation between these parameters and interbody cage height. By measuring the intervertebral height of pathological segment and normal segment to calculate the regression equation of interbody cage height.
  
  
  RESULTS
  The average interbody cage height of male patients (12.38 ± 1.43) mm was significantly higher than female (11.62 ± 1.45) mm (p < 0.001). The L4-5 segment interbody cage height (12.11 ± 1.38) mm was significantly greater than the L5-S1 (11.25 ± 1.32) mm (p = 0.04). Body height, the intervertebral height of pathological segment, and the middle intervertebral heigh of upper adjacent segment were highly positively correlated to the interbody cage height. The range of interbody cage height used in transforaminal lumbar interbody fusion for Chinese patients with lumbar degenerative diseases was: L3-4 (11.28 ± 3.29) mm ~ (12.76 ± 2.40) mm, L4-5 (11.62 ± 2.89) mm ~ (13.18 ± 1.91) mm, L5-S1 (10.52 ± 2.22) mm ~ (11.90 ± 2.80) mm. The regression equation of interbody cage height was: interbody cage height = 11.123-0.563 * (gender) + 0.149 * (the middle intervertebral height of pathological segment).
  
  
  CONCLUSIONS
  The selection of interbody cage height was influenced by sex, body height, pathological segment location, the intervertebral height of pathological segment and other factors. The interbody cage height for the lower lumbar spine mostly selected 11,12,13 mm, L3-4, L4-5 segment highly selective in general should not be less than 10 mm, and L5-S1 segments height was relatively small, usually not more than 13 mm. The interbody cage height might be selected based on the regression equation of interbody cage height. But, the regression equation maybe need to be verified in a prospective study.
authors.affiliation: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai, 200040, China. wanghongli0212@163.com.
authors.forename: Hongli
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai, 200040, China. chen19881027@aliyun.com.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai, 200040, China. jjy@fudanspine.com.
authors.forename: Jianyuan
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai, 200040, China. dr.feizhou@gmail.com.
authors.forename: Feizhou
authors.initials: F
authors.lastname: Lu
authors.affiliation: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai, 200040, China. fudanspine@163.com.
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai, 200040, China. dr.xinlei@gmail.com.
authors.forename: Xinlei
authors.initials: X
authors.lastname: Xia
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016268:Internal Fixators / Q000592:standards; D055959:Intervertebral Disc Degeneration / Q000000981:diagnostic imaging* / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D013123:Spinal Fusion / Q000295:instrumentation* / Q000379:methods