title: Diagnostic utility of SOX11 immunohistochemistry in differentiating cutaneous spread of mantle cell lymphoma from primary cutaneous B-cell lymphomas.
abstract: BACKGROUND
  Mantle cell lymphoma (MCL) is associated with the worst prognosis among low-grade B-cell lymphomas. While cutaneous involvement by nodal or systemic MCL is uncommon, its differentiation from primary cutaneous B-cell lymphoma (CBCL) or cutaneous involvement by other extra-cutaneous BCL is challenging as neither histomorphology nor immunophenotype can be absolutely specific. We analyzed the diagnostic utility of SOX11 immunohistochemistry in differentiating secondary cutaneous MCL from other low-grade CBCL.
  
  
  METHODS
  Immunohistochemical staining with anti-SOX11 antibody was performed on 8 cases of secondary cutaneous MCL, 16 secondary cutaneous CLL, 20 primary cutaneous MZL, 12 cutaneous FCL (6 primary, 6 secondary), 7 primary cutaneous DLBCL, leg type, 5 systemic DLBCL and 3 B-ALL. SOX11 and cyclin D1 staining were compared in secondary cutaneous MCL.
  
  
  RESULTS
  Nuclear SOX11 staining was seen in seven of eight cases (88%) of secondary cutaneous MCL, including a case with minimal cyclin D1 expression. All other CBCL lacked detectable nuclear SOX11 expression. The sensitivity and specificity for SOX11 in MCL were 87.5 and 100%, respectively. Both the sensitivity and specificity for combined SOX11 and cyclin D1 immunohistochemistry were 100%.
  
  
  CONCLUSIONS
  SOX11 immunohistochemistry could be a useful adjunct in distinguishing secondary cutaneous MCL from other CBCL.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: Andy C
authors.initials: AC
authors.lastname: Hsi
authors.affiliation: Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, MO, USA.
authors.forename: M Yadira
authors.initials: MY
authors.lastname: Hurley
authors.affiliation: Division of Dermatology, Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: Sena J
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.|Division of Dermatology, Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: Ilana S
authors.initials: IS
authors.lastname: Rosman
authors.affiliation: Department of Biology, Washington University in St. Louis, Saint Louis, MO, USA.
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Pang
authors.affiliation: Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gru
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.|Division of Dermatology, Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: András
authors.initials: A
authors.lastname: Schaffer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000378:metabolism / Q000473:pathology; D020522:Lymphoma, Mantle-Cell / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D055751:SOXC Transcription Factors / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D009363:Neoplasm Proteins; C097473:SOX11 protein, human; D055751:SOXC Transcription Factors
keywords: SOX11; cutaneous B-cell lymphomas; mantle cell lymphoma