title: Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity.
abstract: Regulatory T cells (Tregs) are comprised of a heterogeneous population of cells that play a vital role in suppressing inflammation and maintaining immune tolerance. Given the crucial role of Tregs in maintaining immune homeostasis, it is probably not surprising that many microbial species and their metabolites have the potential to induce Tregs. There is now great interest in the therapeutic potential of probiotics and prebiotics based strategies for a range of autoimmune disorders. This review will summarise recent findings concerning the role of probiotics and prebiotics in induction of Tregs to ameliorate the autoimmune conditions. In addition, the article is focused to explain the different mechanisms of Treg induction and function by these probiotics and prebiotics, based on the available studies till date. The article further proposes that induction of Tregs by probiotics and prebiotics could lead to the development of new therapeutic approach towards curbing the autoimmune response and as an alternative to detrimental immunosuppressive drugs.
authors.affiliation: C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Tarsadi, Surat, Gujarat -394350, India.
authors.forename: Mitesh
authors.initials: M
authors.lastname: Dwivedi
authors.affiliation: C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Tarsadi, Surat, Gujarat -394350, India.
authors.forename: Prasant
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Department of Molecular Biology, Unipath Specialty Laboratory Ltd., Ahmedabad, Gujarat, India.
authors.forename: Naresh C
authors.initials: NC
authors.lastname: Laddha
authors.affiliation: Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom. Electronic address: e.h.kemp@sheffield.ac.uk.
authors.forename: E Helen
authors.initials: EH
authors.lastname: Kemp
mesh_terms: D015551:Autoimmunity / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D056692:Prebiotics; D019936:Probiotics; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D056692:Prebiotics
keywords: Autoimmunity; CD8(+) T cells; Immune regulation; Prebiotics; Probiotics; Regulatory T cells