title: Development of Endoplasmic Reticulum Stress during Experimental Oxalate Nephrolithiasis.
abstract: Morphological and ultrastructural study of the kidney was performed in rats with oxalate nephrolithiasis. Specific features of endoplasmic reticulum stress were evaluated during nephrolithiasis and treatment with α-tocopherol. We observed the signs of endoplasmic reticulum stress with activation of proapoptotic pathways and injury to the cell lining in nephron tubules and collecting ducts. Ultrastructural changes were found in the organelles, nuclei, and cell membranes of epitheliocytes. A relationship was revealed between endoplasmic reticulum stress and oxidative damage, which developed at the early state of lithogenesis.
authors.affiliation: Altai State Medical University, Barnaul, Russia. pathol@inbox.ru.
authors.forename: Yu G
authors.initials: YG
authors.lastname: Motin
authors.affiliation: Altai State Medical University, Barnaul, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Lepilov
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Bgatova
authors.affiliation: Altai State Medical University, Barnaul, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Zharikov
authors.affiliation: Altai State Medical University, Barnaul, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Motina
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: G A
authors.initials: GA
authors.lastname: Lapii
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyashchikh
mesh_terms: D000818:Animals; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects / Q000502:physiology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D053040:Nephrolithiasis / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D024502:alpha-Tocopherol / Q000494:pharmacology
chemical_list: D024502:alpha-Tocopherol
keywords: endoplasmic reticulum stress; experimental nephrolithiasis; renal epithelium; ultrastructure; α-tocopherol