title: Fibroblast growth factor receptor 4: the missing link between chronic kidney disease and FGF23-induced left ventricular hypertrophy?
abstract: Serum phosphorus and the regulatory hormone fibroblast growth factor 23 have been strongly linked to cardiovascular morbidity and mortality in patients with chronic kidney disease. A recent study identified fibroblast growth factor receptor 4 as the primary receptor mediating the effect of fibroblast growth factor 23 on left ventricular hypertrophy, providing new mechanistic insights and a potential therapeutic target to reduce cardiovascular morbidity in chronic kidney disease.
authors.affiliation: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: Christina.wyatt@mssm.edu.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Wyatt
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) U-1018, Team 5, Hôpital Paul Brousse, Paris-Sud University and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University), Villejuif, France.
authors.forename: Tilman B
authors.initials: TB
authors.lastname: Drüeke
mesh_terms: D000818:Animals; D051518:Fibroblast Growth Factor 3 / Q000097:blood* / Q000235:genetics; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D000090265:Klotho Proteins; D051379:Mice; D010758:Phosphorus / Q000097:blood; D051381:Rats; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D051518:Fibroblast Growth Factor 3; D010758:Phosphorus; D000089703:Fibroblast Growth Factor-23; C496371:FGFR4 protein, human; D051499:Receptor, Fibroblast Growth Factor, Type 4; D005966:Glucuronidase; D000090265:Klotho Proteins