title: Analysis of Antiviral Properties of Hexoral In Vitro against Some Viruses that Cause Acute Respiratory Infections and Herpes.
abstract: Antiviral properties of Hexoral (0.1% solution and 0.2% aerosol for local application) and its constituent hexetidine against viruses causing human respiratory tract infections and herpes virus were studied in vitro. It was found that non-cytotoxic concentrations of hexetidine (alone and as a component of Hexoral) attenuated infectious properties of highly virulent influenza virus A/H5N1, pandemic influenza virus A/H1N1pdm, respiratory syncytial virus, and herpes simplex virus type 1 after a short-term exposure (30 sec) by 100 or more times. It was found that hexidine mostly contributes to the virucidal effect of Hexoral.
authors.affiliation: D. I. Ivanovsky Research Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia. pg_deryabin@mail.ru.
authors.forename: P G
authors.initials: PG
authors.lastname: Deryabin
authors.affiliation: D. I. Ivanovsky Research Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
authors.affiliation: D. I. Ivanovsky Research Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Andronova
authors.affiliation: D. I. Ivanovsky Research Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Botikov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002522:Chlorocebus aethiops; D004285:Dogs; D006590:Hexetidine / Q000494:pharmacology*; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects / Q000472:pathogenicity; D012141:Respiratory Tract Infections / Q000517:prevention & control; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D006590:Hexetidine
keywords: Hexoral; antiviral properties; cell cultures; influenza virus