title: [Experimental models of human skin aging].
abstract: The skin is a representative model for the study of human aging. Despite the high regenerative capacity of the skin, skin physiology changes over the course of life. Medical and cosmetic research is trying to prevent aging, to slow, to stop, or to reverse it. Effects of age-related DNA damage and of changing skin structure on pharmacological parameters are largely unknown. This review article summarizes the state of scientific knowledge in the field of experimental models of human skin aging and shows approaches to improve organotypic skin models, to develop predictive models of aging, and improve aging research.
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Deutschland.|European Union Reference Laboratory for Alternatives to Animal Testing, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Deutschland.
authors.forename: G
authors.initials: G
authors.lastname: Nikolakis
authors.affiliation: Institut für Pharmazie (Pharmakologie und Toxikologie), Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Zoschke
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Deutschland.|Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Life Science Building N27, James-Franck Ring/Meyerhofstraße 11c, 89081, Ulm, Deutschland.
authors.forename: E
authors.initials: E
authors.lastname: Makrantonaki
authors.affiliation: Institut für Pharmazie (Pharmakologie und Toxikologie), Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Hausmann
authors.affiliation: Institut für Pharmazie (Pharmakologie und Toxikologie), Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Schäfer-Korting
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Deutschland. christos.zouboulis@klinikum-dessau.de.|European Union Reference Laboratory for Alternatives to Animal Testing, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Deutschland. christos.zouboulis@klinikum-dessau.de.
authors.forename: C C
authors.initials: CC
authors.lastname: Zouboulis
mesh_terms: D000818:Animals; D019317:Evidence-Based Medicine; D006801:Humans; D023421:Models, Animal; D015595:Skin Aging / Q000473:pathology* / Q000502:physiology*; D013045:Species Specificity
keywords: DNA damage; Drugs; Models, animal; Organotypic skin models; Skin physiology