title: Impact of Skin Toxicities Associated with Targeted Cancer Therapies on Body Image: A Prospective Study.
abstract: OBJECTIVE
  Body-image issues associated with dermatological side effects induced by anticancer-targeted therapies have not been specifically explored until now despite growing literature about their impact on quality of life. Prospective and longitudinal investigations were needed. The aim of our study was to describe body-image changes occurring with cutaneous toxicities and their psychosocial impact on patients.
  
  
  METHODS
  Thirty-three patients were evaluated four times during the first 3 months of targeted therapy in terms of body satisfaction, physical attitudes and depression with validated and ad hoc questionnaires. The NCI-CTCAE V4.0 was used to grade adverse dermatological events. Descriptive and inferential analyses were conducted with SPSS 14.0 software.
  
  
  RESULTS
  Ninety-four per cent of the patients developed skin toxicities. Body satisfaction remained stable and slightly better than average over this period. About one-third of the patients reported body-image issues at baseline. Body satisfaction and depression levels at baseline appeared to be significantly associated with body-image issues after 3 months of therapy.
  
  
  CONCLUSIONS
  In the framework of regular dermatological monitoring, skin toxicities did not appear to be associated with body-image issues. Body satisfaction and depressive symptoms at the beginning of targeted therapy emerged as critical factors that practitioners should consider in order to prevent deterioration of body image that could impact on quality of life and compromise compliance.
authors.affiliation: Psycho-Oncology Unit, Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France. cecile.charles@gustaveroussy.fr.|Laboratory of Psychopathology and Health processes, EA 4057, Psychology Institute, Paris Descartes University-Sorbonne Paris Cité, Boulogne-Billancourt, France. cecile.charles@gustaveroussy.fr.
authors.forename: Cécile
authors.initials: C
authors.lastname: Charles
authors.affiliation: Psychosomatic and Psycho-Oncology Research Unit, University of Brussels-Psycho-Oncology Clinic, Jules Bordet Institute, Brussels, Belgium.
authors.forename: Darius
authors.initials: D
authors.lastname: Razavi
authors.affiliation: Laboratory of Psychopathology and Health processes, EA 4057, Psychology Institute, Paris Descartes University-Sorbonne Paris Cité, Boulogne-Billancourt, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Bungener
authors.affiliation: Dermatology Service, Gustave Roussy Cancer Campus Grand-Paris-Sud Villejuif, Villejuif, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Mateus
authors.affiliation: Department of Biostatistics and Epidemiology, Gustave Roussy, Villejuif, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Lanoy
authors.affiliation: Department of Research and Innovation, L'Oreal, Paris, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Verschoore
authors.affiliation: Psycho-Oncology Unit, Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Dauchy
authors.affiliation: Dermatology Service, Gustave Roussy Cancer Campus Grand-Paris-Sud Villejuif, Villejuif, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Robert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001828:Body Image / Q000523:psychology*; D003863:Depression / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires