title: Confocal and dermoscopic features of basal cell carcinoma in Gorlin-Goltz syndrome: A case report.
abstract: Gorlin-Goltz (GS) syndrome is an autosomal dominant disease linked to a mutation in the PTCH gene. Major criteria include the onset of multiple basal cell carcinoma (BCC), keratocystic odontogenic tumours in the jaws and bifid ribs. Dermoscopy and reflectance confocal microscopy represent imaging tools that are able to increase the diagnostic accuracy of skin cancer in a totally noninvasive manner, without performing punch biopsies. Here we present a case of a young woman in whom the combined approach of dermoscopy and RCM led to the identification of multiple small inconspicuous lesions as BCC and thus to the diagnosis of GS syndrome.
authors.affiliation: Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Alice
authors.initials: A
authors.lastname: Casari
authors.affiliation: Department of Dermatology, Second University of Naples, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Argenziano
authors.affiliation: SkinCancer Unit, Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Elvira
authors.initials: E
authors.lastname: Moscarella
authors.affiliation: SkinCancer Unit, Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Aimilios
authors.initials: A
authors.lastname: Lallas
authors.affiliation: SkinCancer Unit, Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Longo
mesh_terms: D001478:Basal Cell Nevus Syndrome / Q000000981:diagnostic imaging*; D046169:Dermoscopy; D005260:Female; D006801:Humans; D018613:Microscopy, Confocal; D012878:Skin Neoplasms / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: Gorlin-Goltz syndrome; confocal laser microscopy; dermoscopy