title: Early diagnosis of asymptomatic neurocutaneous melanosis (60 month follow-up).
abstract: Neurocutaneous melanosis (NCM) is a rare, sporadic, congenital neuroectodermal dysplasia. Large congenital melanocytic nevi (CMN) can evolve in a certain percentage of patients to NCM. Meningeal deposits are benign, but can be prone to malignant transformation in some cases. We describe the case of an infant with asymptomatic NCM, and typical magnetic resonance imaging (MRI) findings. The diagnosis was established shortly after delivery, and the patient was followed for 60 months. At that time, the girl did not have any neurologic symptoms; she reached normal developmental milestones and did not show mental retardation and did not develop malignant melanoma; further follow-up will be needed, although there are no reliable guidelines as to the time range of follow up of asymptomatic NCM in the literature. We report the typical MRI signal abnormalities of the brain, and present a review of the literature regarding this rare and mysterious congenital disorder.
authors.affiliation: Institute of Radiology, Clinical Center Nis, Serbia, Nis, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Markovic
authors.affiliation: General Hospital "Sava Surgery", Nis, Serbia.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Milenkovic
authors.affiliation: Al Adan Hospital, Pediatric Department, Neurology Unit, Hadya, Kuwait.
authors.forename: Marina
authors.initials: M
authors.lastname: Jovanović
authors.affiliation: Al Sabah Hospital, Pediatric Department, Neurology Department, Kuwait.
authors.forename: Bosanka Jocić
authors.initials: BJ
authors.lastname: Jakubi
authors.affiliation: General Hospital "Sava Surgery", Nis, Serbia.
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Sekulovic-Stefanovic
keywords: giant congenital melanocytic nevi; magnetic resonance imaging; neurocutaneous melanosis; neuroectodermal dysplasia