title: Establishment of TBS reference plots and correlation between TBS and BMD in healthy mainland Chinese women.
abstract: The trabecular bone score (TBS) was obtained from the gray levels of a dual X-ray absorptiometry (DXA) image to evaluate bone microarchitecture. Here, we established the reference plots of TBS in healthy Chinese women of Nanjing area. The TBS references are similar with French and US Caucasian women but higher than Japanese women.
  
  
  OBJECTIVE
  The aim of the study was to establish the reference plots of the TBS in healthy Chinese women of the Nanjing area.
  
  
  METHODS
  A total of 537 healthy Chinese women of the Nanjing area were recruited, and the study was approved by the Ethics Committee of the First Affiliated Hospital with Nanjing Medical University. The TBS of the lumbar spine and the bone mineral density (BMD) of the lumbar spine and femur were measured using dual X-ray absorptiometry. The mean ± standard deviation (SD) of the TBS in women with different age groups was calculated. The correlation of TBS and age and BMD was calculated using regression analysis.
  
  
  RESULTS
  The reference plots of the TBS were established in healthy Chinese women of the Nanjing area between the ages of 20 and 89 years. The average TBS for total subjects was 1.32 ± 0.11 and reached the peak at the age of 20-29 years and then decreased with age thereafter. The determinant coefficient between TBS and age was 0.5065 while between TBS and BMD was 0.5191. After adjusting for lumbar total BMD, the TBS significantly correlated with age in whole subjects and only in the subgroup of ages 50-59 years.
  
  
  CONCLUSIONS
  This study suggested that TBS decreased with age and correlated positively with BMD. The TBS reference of Chinese women is similar with those of French and US Caucasian women but higher than that of Japanese women. Furthermore, the TBS may be more significantly applied in women in menopause for less than 10 years.
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. cphh@sohu.com.
authors.forename: P
authors.initials: P
authors.lastname: Cheng
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. 1398462844@qq.com.
authors.forename: H M
authors.initials: HM
authors.lastname: Qi
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. diwen414@163.com.
authors.forename: W J
authors.initials: WJ
authors.lastname: Di
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. lioujane@126.com.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. tianqu1981@126.com.
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. lvshan3366@126.com.
authors.forename: S
authors.initials: S
authors.lastname: Lv
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. 1605663587@qq.com.
authors.forename: Y L
authors.initials: YL
authors.lastname: Shen
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. zhajuanmin@gmail.com.
authors.forename: J M
authors.initials: JM
authors.lastname: Zha
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. caijinmei110@126.com.
authors.forename: J M
authors.initials: JM
authors.lastname: Cai
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. laibin3377@sina.com.
authors.forename: B
authors.initials: B
authors.lastname: Lai
authors.affiliation: Department of Gerontology, The First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People's Republic of China. dinggx@njmu.edu.cn.
authors.forename: G X
authors.initials: GX
authors.lastname: Ding
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D002681:China / Q000208:ethnology; D005260:Female; D005269:Femur / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008875:Middle Aged; D012016:Reference Values; D012044:Regression Analysis; D055815:Young Adult
keywords: BMD; Bone microarchitecture; Chinese women; Osteoporosis; TBS