title: Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium.
abstract: OBJECTIVE
  The aim of this study is to compare implantation and live birth rates (LBR) between fresh euploid embryo transfers versus cryo-all cycles with a subsequent embryo transfer into a prepared endometrium.
  
  
  METHODS
  This is a retrospective cohort study. Patients who underwent an IVF cycle with PGS with trophectoderm biopsy from January 2011 to July 2015 were included. Patients were divided into three groups: "Fresh Only," "Frozen Embryo Transfer ('FET) Only," and "Fresh ET then FET." For "Fresh Only" group (n = 345), PGS results were received within 24 h. For "FET Only" group (n = 514), results were expected after 24 h, and embryos were cryopreserved after biopsy; only FET was performed in this group (no fresh transfer). For "FET with a previous fresh ET" (n = 139) group, patients underwent a fresh ET with a subsequent FET, in which the same cohort of embryos was utilized. The main outcome measures were pregnancy rate (PR), clinical PR, implantation rate (IR), LBR, and early pregnancy loss rate.
  
  
  RESULTS
  IRs were statistically higher in the "FET Only" group when compared to the "Fresh Only" group (59.5 vs. 50.6%, p < 0.01) and the "FET with a previous fresh ET" (59.5 vs. 50.6%, p < 0.05). LBR was statistically significant in the "FET Only" group when compared to the "Fresh Only" group (57.6 vs. 46.5 %, p < 0.005) but not when compared to "FET with a previous fresh ET" group (57.6 vs. 47.7%, p = 0.07).
  
  
  CONCLUSIONS
  This analysis suggests euploid embryos to be more likely to implant and achieve a LBR in a synthetic FET cycle than in a fresh cycle.
authors.affiliation: Reproductive Medicine Associates of New York, 635 Madison Ave 10th Floor, New York City, NY, 10022, USA. jrodriguez@rmany.com.
authors.forename: Jorge
authors.initials: J
authors.lastname: Rodriguez-Purata
authors.affiliation: Reproductive Medicine Associates of New York, 635 Madison Ave 10th Floor, New York City, NY, 10022, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Lee
authors.affiliation: Reproductive Medicine Associates of New York, 635 Madison Ave 10th Floor, New York City, NY, 10022, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Whitehouse
authors.affiliation: Reproductive Medicine Associates of New York, 635 Madison Ave 10th Floor, New York City, NY, 10022, USA.
authors.forename: Marlena
authors.initials: M
authors.lastname: Duke
authors.affiliation: Reproductive Medicine Associates of New York, 635 Madison Ave 10th Floor, New York City, NY, 10022, USA.|Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Klingenstein Pavilion 1176 Fifth Avenue 9th Floor, New York City, NY, 10029, USA.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Grunfeld
authors.affiliation: Reproductive Medicine Associates of New York, 635 Madison Ave 10th Floor, New York City, NY, 10022, USA.|Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Klingenstein Pavilion 1176 Fifth Avenue 9th Floor, New York City, NY, 10029, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Sandler
authors.affiliation: Reproductive Medicine Associates of New York, 635 Madison Ave 10th Floor, New York City, NY, 10022, USA.|Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Klingenstein Pavilion 1176 Fifth Avenue 9th Floor, New York City, NY, 10029, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Copperman
authors.affiliation: Reproductive Medicine Associates of New York, 635 Madison Ave 10th Floor, New York City, NY, 10022, USA.|Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Klingenstein Pavilion 1176 Fifth Avenue 9th Floor, New York City, NY, 10029, USA.
authors.forename: Tanmoy
authors.initials: T
authors.lastname: Mukherjee
mesh_terms: D000328:Adult; D000782:Aneuploidy; D001755:Blastocyst / Q000502:physiology*; D015331:Cohort Studies; D015925:Cryopreservation / Q000379:methods*; D010064:Embryo Implantation / Q000235:genetics; D004624:Embryo Transfer / Q000379:methods*; D004717:Endometrium / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Euploid embryos; Fresh embryo transfer; Frozen embryo transfer; Preimplantation genetic screening; Vitrification