title: How dynein and dynactin transport cargos: a structural perspective.
abstract: Recent structures of the dynein motor in three different conformations reveal how it uses ATP hydrolysis to move along microtubules. Attention is now turning to how cytoplasmic dynein-1 and dynactin act together to carry cargos. Cryo-electron microscopy (cryo-EM) has revealed the structure of dynactin and how it binds dynein in the presence of a cargo adaptor protein Bicaudal-D2 (BICD2). Future questions will include how dynein-1 transports so many different cargos and how the 2.4MDa dynein/dynactin transport machine is regulated.
authors.affiliation: MRC Lab of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom. Electronic address: cartera@mrc-lmb.cam.ac.uk.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Carter
authors.affiliation: MRC Lab of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom.
authors.forename: Aristides G
authors.initials: AG
authors.lastname: Diamant
authors.affiliation: MRC Lab of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom.
authors.forename: Linas
authors.initials: L
authors.lastname: Urnavicius
mesh_terms: D002384:Catalysis; D000072159:Dynactin Complex / Q000737:chemistry / Q000378:metabolism*; D004398:Dyneins / Q000737:chemistry / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D000072159:Dynactin Complex; D004398:Dyneins