title: Sensitivity analysis of the position of the intervertebral centres of reaction in upright standing--a musculoskeletal model investigation of the lumbar spine.
abstract: The loads between adjacent vertebrae can be generalised as a single spatial force acting at the intervertebral centre of reaction. The exact position in vivo is unknown. However, in rigid body musculoskeletal models that simulate upright standing, the position is generally assumed to be located at the discs' centres of rotation. The influence of the antero-posterior position of the centre of reaction on muscle activity and joint loads remains unknown. Thus, by using an inverse dynamic model, we varied the position of the centre of reaction at L4/L5 (i), simultaneously at all lumbar levels (ii), and by optimisation at all lumbar levels (iii). Variation of the centres of reaction can considerably influence the activities of lumbar muscles and the joint forces between vertebrae. The optimisation of the position of the centre of reaction reduced the maximum lumbar muscle activity and axial joint forces at L4/L5 from 17.5% to 1.5% of the muscle strength and from 490 N to 390 N, respectively. Thus, when studying individual postures, such as for therapeutic or preventive evaluations, potential differences between the centre of reaction and the centre of rotation might influence the study results. These differences could be taken into account by sensitivity analyses.
authors.affiliation: Julius Wolff Institute, Charité - Universitätsmedizin, Augustenburger Platz 1, D-13353 Berlin, Germany. Electronic address: thomas.zander@charite.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Zander
authors.affiliation: Julius Wolff Institute, Charité - Universitätsmedizin, Augustenburger Platz 1, D-13353 Berlin, Germany.
authors.forename: Marcel
authors.initials: M
authors.lastname: Dreischarf
authors.affiliation: Julius Wolff Institute, Charité - Universitätsmedizin, Augustenburger Platz 1, D-13353 Berlin, Germany.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Schmidt
mesh_terms: D006801:Humans; D007403:Intervertebral Disc / Q000033:anatomy & histology / Q000502:physiology*; D008159:Lumbar Vertebrae / Q000033:anatomy & histology / Q000502:physiology*; D008953:Models, Anatomic; D008954:Models, Biological; D009132:Muscles / Q000033:anatomy & histology / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D016474:Weight-Bearing
keywords: Centre of reaction; Centre of rotation; Musculoskeletal model; Standing; Static equilibrium