title: Successful Use of Early Percutaneous Dilatational Tracheotomy and the No Sedation Concept in Respiratory Failure in Critically Ill Obese Subjects.
abstract: BACKGROUND
  The prevalence of obesity in developed countries is rising. Currently, Europe has a prevalence of 9-30% with significant impact on public health systems. Obese patients in ICUs require special management and treatment. Altered anatomy in obese patients complicates procedures such as mechanical ventilation. Obesity affects cardiopulmonary physiology and requires elevated ventilation pressures. In our retrospective study, we determined the effect of early percutaneous dilatational tracheotomy (PDT) and cessation of sedation on respiratory parameters in severely obese subjects.
  
  
  METHODS
  From June 2010 to July 2014, we included all subjects with a body weight of >130 kg (body mass index >35 kg/m(2)) and respiratory failure who were admitted to the medical ICU of the University Hospital of Münster. All subjects were treated with early PDT and immediate cessation of sedative drugs. We compared ventilator parameters and blood gas analysis before and after PDT. Parameters were recorded on days 0, 1, 3, and 5. Day 0 represents values during ventilation via an endotracheal tube, and days 1, 3, 5 represent values during ventilation via a tracheotomy tube. PDT was performed on day 0 after recording values during ventilation via an endotracheal tube.
  
  
  RESULTS
  We included 23 subjects with a mean body mass index of 53.1 kg/m(2) and respiratory failure. After PDT and cessation of sedation, the required ventilation pressures and FIO2 could be rapidly reduced (P < .001), whereas blood gas parameters significantly improved. We observed no severe PDT-associated complications in our cohort.
  
  
  CONCLUSIONS
  In severe obesity, respiratory failure might be increased by problems in mechanical ventilation due to required high pressures and obesity-induced pulmonary restriction. Rapid tracheotomy with reduction of dead-space ventilation and airway resistance as well as cessation of sedation to enable spontaneous breathing might be a key factor in the therapy of respiratory failure.
authors.affiliation: Division of Electrophysiology, Department of Cardiovascular Medicine, University of Münster, Münster, Germany. sven.kaese@ukmuenster.de.
authors.forename: Sven
authors.initials: S
authors.lastname: Kaese
authors.affiliation: Division of Cardiology, Department of Cardiovascular Medicine, University of Münster, Münster, Germany.
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Zander
authors.affiliation: Division of Cardiology, Department of Cardiovascular Medicine, University of Münster, Münster, Germany.
authors.forename: Pia
authors.initials: P
authors.lastname: Lebiedz
mesh_terms: D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D016638:Critical Illness / Q000628:therapy; D054810:Deep Sedation; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000379:methods; D012131:Respiratory Insufficiency / Q000150:complications / Q000628:therapy*; D012189:Retrospective Studies; D014140:Tracheotomy / Q000009:adverse effects / Q000379:methods*
keywords: intensive care unit; mechanical ventilation; obesity; percutaneous dilatational tracheotomy; respiratory failure; sedation