title: Plasma Content of Glucose, C-reactive Protein, Uric Acid and Cholesterol in Male, Female and Ovariectomized Rats upon Acute and Chronic Stress--a Path for Development of Cardiovascular Diseases.
abstract: To explore sex differences in cardiovascular function under stress, we analyzed plasma levels of glucose, C-reactive protein (CRP), uric acid and cholesterol in male, female and ovariectomized rats under acute and chronic stress. Glucose tolerance test (GTT) was performed in all rats before any stress was performed, as well as later in the chronic stress experiment. GTT in control animals showed the same trend as in chronically stressed. Male rats showed the highest plasma level of glucose and uric acid upon acute stress in comparison between the other two groups. Ovariectomized rats reached the highest concentration of plasma cholesterol during acute and chronic stress, respectively and also the highest plasma concentration of CRP during acute stress. Stress, as a risk factor of metabolic syndrome, affected biochemical parameters in males upon acute more than upon chronic stress, but the opposite was observed in female rats. Gender differences supported by ovariectomy show that stress managing could be affected by sexual hormones.
authors.forename: Marta
authors.initials: M
authors.lastname: Balog
authors.forename: Dražen
authors.initials: D
authors.lastname: Mlinarević
authors.forename: Vatroslav
authors.initials: V
authors.lastname: Šerić
authors.forename: Milan
authors.initials: M
authors.lastname: Miljanović
authors.forename: Robert
authors.initials: R
authors.lastname: Blažeković
authors.forename: Ivan Večeslav
authors.initials: IV
authors.lastname: Degmečić
authors.forename: Senka
authors.initials: S
authors.lastname: Blažetić
authors.forename: Ivana
authors.initials: I
authors.lastname: Oršolić
authors.forename: Sandor G
authors.initials: SG
authors.lastname: Vari
authors.forename: Marija
authors.initials: M
authors.lastname: Heffer
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D002784:Cholesterol / Q000097:blood*; D005260:Female; D008297:Male; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors; D012727:Sex Characteristics; D013315:Stress, Psychological / Q000150:complications*; D014527:Uric Acid / Q000097:blood*
chemical_list: D001786:Blood Glucose; D014527:Uric Acid; D002097:C-Reactive Protein; D002784:Cholesterol