title: [Susceptibility status of Anopheles gambiae sensu lato to insecticides commonly used for malaria control in Mali].
abstract: The objective of this work was to monitor the susceptibility of malaria vectors to insecticides in nine sentinel sites of the National Malaria Control Program in Mali. The study was performed during the rainy seasons of 2010 and 2011. WHO bioassays were conducted using F0 and/or F1 from wild collected females. The insecticides used were lambda-cyhalothrin 0.05%, DDT 4%, permethrin 0.75%, deltamethrin 0.05%, bendiocarb 0.1% and fenitrothion 1.0%. Results showed suspicion of resistance to pyrethroids and organochlorine in An. gambiae s.l. at almost all the sites except Yanfolila where the vector was susceptible to lambda-cyhalothrin (98.0%) [CI 95%, 98-99.8] and to DDT (100%). An. gambiae s.l. was susceptible to bendiocarb in five of the sites (Gao, Bougouni, Djenné, Yanfolila, Tombouctou) while there was a suspicion of resistance at the other sites (Kati, Niono, Bandiagara, Kita). Fenitrothion remains efficient except in the rice area of Niono, where there was a suspicion of resistance with a mortality rate of 92% [IC 95% 88.3-94.8]. Thus, it could be used as an alternative insecticide for IRS in Mali. These results show resistance to pyrethroids, the main insecticide family used in public health (and to some extent in agriculture). This could compromise the malaria vector control efforts in Mali where pyrethroids are used for both in bed nets and in IRS.
authors.affiliation: Malaria Research and Training center, Faculté de médecine et d'odontostomatologie (FMOS), Université des sciences, des techniques et des technologies de Bamako, BP, 1805, Bamako, Mali. moussa@icermali.org.
authors.forename: M
authors.initials: M
authors.lastname: Keïta
authors.affiliation: Programme national de lutte contre le paludisme, Bamako, Mali.
authors.forename: S
authors.initials: S
authors.lastname: Traoré
authors.affiliation: Malaria Research and Training center, Faculté de médecine et d'odontostomatologie (FMOS), Université des sciences, des techniques et des technologies de Bamako, BP, 1805, Bamako, Mali.
authors.forename: N
authors.initials: N
authors.lastname: Sogoba
authors.affiliation: Programme national de lutte contre le paludisme, Bamako, Mali.
authors.forename: A M
authors.initials: AM
authors.lastname: Dicko
authors.affiliation: Malaria Research and Training center, Faculté de médecine et d'odontostomatologie (FMOS), Université des sciences, des techniques et des technologies de Bamako, BP, 1805, Bamako, Mali.
authors.forename: B
authors.initials: B
authors.lastname: Coulibaly
authors.affiliation: Malaria Research and Training center, Faculté de médecine et d'odontostomatologie (FMOS), Université des sciences, des techniques et des technologies de Bamako, BP, 1805, Bamako, Mali.
authors.forename: A
authors.initials: A
authors.lastname: Sacko
authors.affiliation: Malaria Research and Training center, Faculté de médecine et d'odontostomatologie (FMOS), Université des sciences, des techniques et des technologies de Bamako, BP, 1805, Bamako, Mali.
authors.forename: S
authors.initials: S
authors.lastname: Doumbia
authors.affiliation: Malaria Research and Training center, Faculté de médecine et d'odontostomatologie (FMOS), Université des sciences, des techniques et des technologies de Bamako, BP, 1805, Bamako, Mali.
authors.forename: S F
authors.initials: SF
authors.lastname: Traoré
mesh_terms: D000818:Animals; D000852:Anopheles / Q000187:drug effects* / Q000254:growth & development; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007303:Insect Vectors / Q000187:drug effects* / Q000254:growth & development; D007305:Insecticide Resistance; D007306:Insecticides / Q000494:pharmacology*; D008288:Malaria / Q000517:prevention & control* / Q000635:transmission; D008302:Mali / Q000453:epidemiology; D009032:Mosquito Control / Q000379:methods* / Q000592:standards
chemical_list: D007306:Insecticides
keywords: Bendiocarb; DDT; Deltamethrin; Fenitrothion; Insecticides; Lambda-cyhalothrin; Malaria vectors; Mali; Permethrin; Resistance; Sensibility; Sub-Saharan Africa