title: Correlation between olfactory acuity and sinonasal radiological findings in adult patients with chronic rhinosinusitis.
abstract: OBJECTIVE
  This study aimed to clarify the correlation between olfactory disorder severity and radiological findings in patients with chronic rhinosinusitis (CRS) in the preoperative stage.
  
  
  METHODS
  From 2007 to 2014, 272 adult patients (163 men, 109 women; age range 22-80 years) with olfactory disorder due to bilateral CRS who were scheduled to undergo primary endoscopic sinus surgery (ESS) were enrolled. Two groups were studied: eosinophilic CRS (ECRS, n=193); and non-ECRS (n=79). T&T olfactometer recognition and intravenous olfaction tests were used. Computed tomography (CT) scores for sinuses and olfactory clefts (OC) were applied. Correlations between olfactory acuity and CT score were statistically analysed.
  
  
  RESULTS
  In both groups, recognition threshold correlated significantly with CT score. Recognition threshold and CT score were significantly more severe in ECRS than in non-ECRS. CT score at OC showed the strongest correlation with recognition threshold. CT scores for total sinuses and OC in patients showing a positive response to the intravenous olfaction test (239 patients) were significantly milder than those in the negative group (29 patients), but ethmoid CT score was not.
  
  
  CONCLUSIONS
  Olfactory disorder severity correlated significantly with CT opacification. Olfactory disorder and CT findings were more severe in patients with ECRS than in those with non-ECRS.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Saito
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan. Electronic address: kenzo@hyo-med.ac.jp.
authors.forename: Kenzo
authors.initials: K
authors.lastname: Tsuzuki
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Yukitatsu
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Sakagami
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D004802:Eosinophilia / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D000857:Olfaction Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D012220:Rhinitis / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012684:Sensory Thresholds; D012852:Sinusitis / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012903:Smell; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: CT score; Eosinophilic rhinosinusitis (ECRS); Intravenous olfaction test; Olfactory disorder; Recognition threshold