title: Prognostic value of preoperative peripheral monocyte count in patients with hepatocellular carcinoma after liver transplantation.
abstract: Prognostic value of peripheral monocyte, as a member of inflammatory cells, was widely being investigated. The aim of this study was to evaluate the prognostic value of preoperative peripheral blood monocyte count for hepatocellular carcinoma (HCC) patients who underwent liver transplantation (LT) and the relationship between monocyte count and tumor-related characteristics. We retrospectively analyzed the clinical data of 101 HCC patients after LT. Preoperative monocyte count and demographic, clinical, and pathologic data were analyzed. The optimal cutoff value of monocyte count was 456/mm(3), with the sensitivity and specificity of 69.4 and 61.5 %, respectively. Elevated preoperative peripheral blood monocyte count was significantly associated with large tumor size. The 1-, 3-, and 5-year disease-free survival (DFS) (80.9, 70.1, and 53.3 % vs 55.1, 38.7, and 38.7 %, P = 0.007) and overall survival (OS) rates (95.7, 76.6, and 64.8 % vs 72.2, 44.1, and 36.1 %, P = 0.002) of HCC patients in the peripheral blood monocyte count ≤456/mm(3) group were higher than those in the peripheral blood monocyte count >456/mm(3) group. In conclusion, elevated preoperative peripheral blood monocyte count was significantly associated with advanced tumor stage and it can be considered as a prognostic factor for HCC patients after LT.
authors.affiliation: Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
authors.forename: Qing-Qi
authors.initials: QQ
authors.lastname: Ren
authors.affiliation: Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Fu
authors.affiliation: Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Guo
authors.affiliation: Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ji
authors.affiliation: Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
authors.forename: Mao-Gen
authors.initials: MG
authors.lastname: Chen
authors.affiliation: Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China. lw97002@163.com.
authors.forename: Lin-Wei
authors.initials: LW
authors.lastname: Wu
authors.affiliation: Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China. gdtrc@163.com.
authors.forename: Xiao-Shun
authors.initials: XS
authors.lastname: He
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000379:methods; D007963:Leukocytes, Mononuclear / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology*; D016031:Liver Transplantation / Q000379:methods; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D057234:Preoperative Period; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
keywords: Hepatocellular carcinoma; Liver transplantation; Peripheral blood monocyte count; Prognosis