title: The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress.
abstract: Dopamine is a neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dysfunction of the dopamine system has been implicated in different nervous system diseases. The level of dopamine transmission increases in response to any type of reward and by a large number of strongly additive drugs. The role of dopamine dysfunction as a consequence of oxidative stress is involved in health and disease. Introduce new potential targets for the development of therapeutic interventions based on antioxidant compounds. The present review focuses on the therapeutic potential of antioxidant compounds as a coadjuvant treatment to conventional neurological disorders is discussed.
authors.affiliation: Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP), 04530 Ciudad de México, DF, Mexico; Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, 04130 Ciudad de México, DF, Mexico.
authors.forename: Hugo
authors.initials: H
authors.lastname: Juárez Olguín
authors.affiliation: Laboratorio de Neuroquimica, INP, 04530 Ciudad de México, DF, Mexico.
authors.forename: David
authors.initials: D
authors.lastname: Calderón Guzmán
authors.affiliation: Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP), 04530 Ciudad de México, DF, Mexico.
authors.forename: Ernestina
authors.initials: E
authors.lastname: Hernández García
authors.affiliation: Laboratorio de Neuroquimica, INP, 04530 Ciudad de México, DF, Mexico.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Barragán Mejía
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D004298:Dopamine / Q000737:chemistry / Q000378:metabolism*; D004703:Endocrine System / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D011954:Receptors, Dopamine / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D018696:Neuroprotective Agents; D011954:Receptors, Dopamine; D004298:Dopamine