title: White matter alterations associated with suicide in patients with schizophrenia or schizophreniform disorder.
abstract: The risk of suicide is disproportionately high among people diagnosed with schizophrenia or schizophreniform disorder. Brain imaging studies have shown a few relationships between neuroanatomy and suicide. This study examines the relationship between alterations in brain white matter (WM) and suicidal behavior in people with schizophrenia or schizophreniform disorder. The study participants were 56 patients with schizophrenia or schizophreniform disorder, with (n=15) and without (n=41) a history of suicide attempts. Fractional anisotropy (FA) values were compared between suicide attempters and non-attempters using Tract-Based Spatial Statistics (TBSS). Attempters showed significantly higher FA values than non-attempters in the left corona radiata, the superior longitudinal fasciculus, the posterior limb and retrolenticular part of the internal capsule, the external capsule, the insula, the posterior thalamic radiation, the cerebral peduncle, the sagittal stratum, and temporal lobe WM. Scores of the picture arrangement test showed a significant positive correlation with FA values of the right corona radiata, the right superior longitudinal fasciculus, the body of the corpus callosum, and the left corona radiata in attempters but not in non-attempters. These findings suggest that fronto-temporo-limbic circuits can be associated mainly with suicidal behavior in people with schizophrenia or schizophreniform disorder.
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Sung-Jae
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Borah
authors.initials: B
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Daeyoung
authors.initials: D
authors.lastname: Oh
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Min-Kyoung
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Keun-Hyang
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Public Health, Graduate School of Health and Welfare, CHA University, Seongnam, Republic of Korea.
authors.forename: Seong Yun
authors.initials: SY
authors.lastname: Bang
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Tai Kiu
authors.initials: TK
authors.lastname: Choi
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea. Electronic address: leesanghyuk@yahoo.com.
authors.forename: Sang-Hyuk
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000150:complications / Q000473:pathology*; D012559:Schizophrenia / Q000150:complications / Q000473:pathology*; D013406:Suicide, Attempted; D066127:White Matter / Q000473:pathology*
keywords: Magnetic resonance imaging; Schizophrenia; Schizophreniform disorder; Suicide; White matter integrity