title: Exploiting the commons: cyclic diguanylate regulation of bacterial exopolysaccharide production.
abstract: Nowadays, there is increasing interest for bacterial polysaccharides in a wide variety of industrial sectors. This is due to their chemical and reological properties, and also the possibility to be obtained by fermentation processes. Biosynthesis of a growing number of exopolysaccharides (EPS) has been reported to be regulated by the ubiquitous second messenger c-di-GMP in a limited number of bacterial species. Since most bacteria are yet unexplored, it is likely that an unsuspected number and variety of EPS structures activated by c-di-GMP await to be uncovered. In the search of new EPS, manipulation of bacterial c-di-GMP metabolism can be combined with high throughput approaches for screening of large collections of bacteria. In addition, c-di-GMP activation of EPS production and promotion of cell aggregation may have direct applications in environmental industries related with biofuel production or wastewater treatments.
authors.affiliation: Dpto. Microbiología del Suelo y Sistemas Simbióticos, Estación Experimental del Zaidín, CSIC. Prof. Albareda N° 1, 18008 Granada, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pérez-Mendoza
authors.affiliation: Dpto. Microbiología del Suelo y Sistemas Simbióticos, Estación Experimental del Zaidín, CSIC. Prof. Albareda N° 1, 18008 Granada, Spain.. Electronic address: Juan.Sanjuan@eez.csic.es.
authors.forename: Juan
authors.initials: J
authors.lastname: Sanjuán
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis*
chemical_list: D001426:Bacterial Proteins; D011135:Polysaccharides, Bacterial; C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP