title: Rapid quantitative T2mapping of the prostate using three-dimensional dual echo steady state MRI at 3T.
abstract: To develop and evaluate a rapid three-dimensional (3D) quantitative T2mapping method for prostate cancer imaging using dual echo steady state (DESS) MRI at 3T.
  
  
  
  In simulations, DESS-T2mapping in the presence of T1and B1+ variations was evaluated. In a phantom and in healthy volunteers (n = 4), 3D DESS-T2mapping was compared with a two-dimensional turbo spin echo (TSE) approach. In volunteers and a pilot patient study (n = 29), quantitative T2in normal prostate anatomical zones and in suspected cancerous lesions was evaluated.
  
  
  
  The simulated bias for DESS-T2was < 2% (5%) for typically observed T1( B1+) variations. In phantoms and in vivo, high correlation of DESS-T2and TSE-T2(r2= 0.98 and 0.88, P < 0.001) was found. DESS-T2in the normal peripheral zone and transition zone was 115 ± 26 ms and 64 ± 7 ms, respectively, in healthy volunteers and 129 ± 39 ms and 83 ± 12 ms, respectively, in patients. In suspected cancerous lesions, DESS-T2was 72 ± 14 ms, which was significantly decreased from the normal peripheral zone (P < 0.001) but not from the transition zone.
  
  
  
  Rapid 3D T2mapping in the entire prostate can be performed in 1 min using DESS MRI. Magn Reson Med 76:1720-1729, 2016. © 2016 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Department of Radiological Sciences, University of California, Los Angeles, California, USA.
authors.forename: Isabel
authors.initials: I
authors.lastname: Dregely
authors.affiliation: Department of Radiological Sciences, University of California, Los Angeles, California, USA.
authors.forename: Daniel A J
authors.initials: DA
authors.lastname: Margolis
authors.affiliation: Department of Radiological Sciences, University of California, Los Angeles, California, USA.
authors.forename: Kyunghyun
authors.initials: K
authors.lastname: Sung
authors.affiliation: Department of Radiological Sciences, University of California, Los Angeles, California, USA.
authors.forename: Ziwu
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Radiological Sciences, University of California, Los Angeles, California, USA.
authors.forename: Novena
authors.initials: N
authors.lastname: Rangwala
authors.affiliation: Department of Radiological Sciences, University of California, Los Angeles, California, USA.
authors.forename: Steven S
authors.initials: SS
authors.lastname: Raman
authors.affiliation: Department of Radiological Sciences, University of California, Los Angeles, California, USA.
authors.forename: Holden H
authors.initials: HH
authors.lastname: Wu
mesh_terms: D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
keywords: 3T MRI; T2 mapping; dual echo steady state (DESS) MRI; prostate cancer imaging