title: Feasibility of 24-Hr Urine Collection for Measurement of Biomarkers in Community-Dwelling Older Adults.
abstract: Biologic markers are becoming a key part of gerontological research, including their measurement at multiple intervals to detect changes over time. This report examined the feasibility and quality of 24-hr urine collection to measure neuroendocrine biomarkers in a community-based sample of older caregivers and non-caregivers. At each interview, participants were instructed on the correct method to collect and store the sample. As incentives, participants selected a day for urine collection within 5 days of the interview, received a reimbursement, and study staff travelled to their home to retrieve the specimen. Between 2008 and 2013, 256 participants were enrolled; all but two participants (99%) provided a baseline urine specimen, of which 93% were considered adequate. Urine collection and quality remained high over three annual follow-up interviews and did not vary by caregiver status or perceived stress level. Our results indicate that 24-hr urine collection is feasible in active, community-dwelling older adults.
authors.affiliation: 1 Boston University, MA, USA.
authors.forename: Sherri O
authors.initials: SO
authors.lastname: Stuver
authors.affiliation: 1 Boston University, MA, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Lyons
authors.affiliation: 1 Boston University, MA, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Coviello
authors.affiliation: 1 Boston University, MA, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Fredman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000652:urine*; D015415:Biomarkers / Q000652:urine*; D001900:Boston; D017028:Caregivers / Q000523:psychology*; D005260:Female; D006801:Humans; D057187:Independent Living; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013315:Stress, Psychological / Q000652:urine*; D059349:Urine Specimen Collection
chemical_list: D015415:Biomarkers
keywords: biological samples; caregiving; longitudinal study