title: Impaired gait kinematics in type 1 Gaucher's Disease.
abstract: Type 1 Gaucher's disease (GD1) is traditionally regarded as "non-neurological". Spatiotemporal and kinematic analysis of gait was carried on thirteen GD1 patients and thirteen healthy controls. We identified a previously unknown subclinical reduction of amplitude of movements in GD1. Articular excursion of ankle, knee and hip was reduced during the swing phase of gait (p <  0.0001). Furthermore, the excursion of the knee appeared also significantly more asymmetric in GD1 patients (p = 0.02). Correction for age, BMI and basal walking speed did not modify the significance. Accordingly to the recent observations that GD1 predisposes to Parkinson's disease, the impaired and asymmetric gait kinematics that we observed might be interpreted as a form of extrapyramidal involvement.
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Italy.|Department of Clinical Neurophysiology, VUmc, Amsterdam, Nederlands.
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Sorrentino
authors.affiliation: Department of Clinical Medicine, University of Naples Federico II, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Barbato
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Del Gaudio
authors.affiliation: Department of Motor Sciences and Wellness, University of Naples Parthenope, Italy.|Institute Hermitage-Capodimonte, Naples, Italy.
authors.forename: Rosaria
authors.initials: R
authors.lastname: Rucco
authors.affiliation: Department of Motor Sciences and Wellness, University of Naples Parthenope, Italy.|Institute Hermitage-Capodimonte, Naples, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Varriale
authors.affiliation: Division of Pediatrics, Moscati Hospital, Aversa (CE), Italy.
authors.forename: Michelina
authors.initials: M
authors.lastname: Sibilio
authors.affiliation: Department of Clinical Medicine, University of Naples Federico II, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Strazzullo
authors.affiliation: Department of Motor Sciences and Wellness, University of Naples Parthenope, Italy.|Institute Hermitage-Capodimonte, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sorrentino
authors.affiliation: Department of Motor Sciences and Wellness, University of Naples Parthenope, Italy.|Institute Hermitage-Capodimonte, Naples, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Agosti
mesh_terms: D000328:Adult; D000368:Aged; D001696:Biomechanical Phenomena / Q000502:physiology; D005260:Female; D005684:Gait / Q000502:physiology; D020233:Gait Disorders, Neurologic / Q000209:etiology*; D005776:Gaucher Disease / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
keywords: Gaucher’s disease; Parkinson disease; extrapyramidal system; gait analysis; joint excursion; parkinsonism