title: Frequency of Celiac Disease in Patients With Increased Intestinal Gas (Flatulence).
abstract: Excessive flatulence which impairs social performance in patients is one of the common reasons for referrals to gastroenterology clinics. Celiac Disease is a rare but important cause of increased intestinal gas (bloating) and if not diagnosed, patients face complications such as malabsorption, anemia, osteoporosis and even intestinal lymphoma. This study aimed to determine the frequency of Celiac Disease in patients with excessive flatulence.One hundred and fifty patients with a chief complaint of experiencing flatulence more than 15 times a day and lasting for three months were referred to the gastroenterology clinic of Rasoul-e-Akram Teaching Hospital. Serological tests for Celiac Disease, Anti TTG Ab (IgA-IgG) were requested and the patients with positive tests underwent upper GI endoscopy. Biopsies of the second part of the duodenum were then sent to the laboratory.From one hundred and thirty patients who completed the study, 92 (70.7%) were female. Mean age of the patients was 32 ± 13 years. Anti TTG Ab was found in 5 patients (3.85%). Only 2 patients (1.5%) had a documented positive pathology for Celiac Disease.According to the results of this study and other studies, we conclude that Celiac Disease is an uncommon etiology for excessive flatulence but it is of importance to investigate it in excessive flatulence patients.
authors.affiliation: Colorectal Research Center, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. masoodi47@gmail.com.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Masoodi
authors.forename: Marjan
authors.initials: M
authors.lastname: Mokhtare
authors.forename: Shahram
authors.initials: S
authors.lastname: Agah
authors.forename: Mohammad
authors.initials: M
authors.lastname: Sina
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Soltani-Kermanshahi
mesh_terms: D000328:Adult; D000368:Aged; D015984:Causality; D002446:Celiac Disease / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005414:Flatulence / Q000453:epidemiology*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D055815:Young Adult