title: In silico analyses of antigenicity and surface structure variation of an emerging porcine circovirus genotype 2b mutant, prevalent in southern China from 2013 to 2015.
abstract: Porcine circovirus type 2 (PCV2) is the pivotal pathogen causing porcine circovirus-associated diseases. In this study, 62 PCV2 isolates were identified from seven farms in southern China from 2013 to 2015 and phylogenetic trees were reconstructed based on whole-genome sequences or the cap gene. In this investigation, PCV2b was the main genotype in circulation throughout these farms. Furthermore, an emerging mutant (PCV2b-1C), isolated from PCV2-vaccinated farms, was the predominant strain prevalent on these farms. In addition, we isolated a new cluster that may represent evolution of the virus through recombination of PCV2b-1A/1B and PCV2b-1C. Finally, we discuss evidence that antigenicity and surface structure variation of the capsid resulted from mutation of the C-terminal loop (Loop CT) of the PCV2b-1C Cap in silico.
authors.affiliation: Research Center of Functional Proteomics, College of Veterinary Medicine, Hunan Agricultural University, Changsha, PRChina.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhan
authors.affiliation: Research Center of Functional Proteomics, College of Veterinary Medicine, Hunan Agricultural University, Changsha, PRChina.
authors.forename: Naidong
authors.initials: N
authors.lastname: Wang
authors.affiliation: Research Center of Functional Proteomics, College of Veterinary Medicine, Hunan Agricultural University, Changsha, PRChina.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Research Center of Functional Proteomics, College of Veterinary Medicine, Hunan Agricultural University, Changsha, PRChina.
authors.forename: Zhanfeng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Research Center of Functional Proteomics, College of Veterinary Medicine, Hunan Agricultural University, Changsha, PRChina.
authors.forename: Aibing
authors.initials: A
authors.lastname: Wang
authors.affiliation: Research Center of Functional Proteomics, College of Veterinary Medicine, Hunan Agricultural University, Changsha, PRChina.
authors.forename: Zhibang
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Research Center of Functional Proteomics, College of Veterinary Medicine, Hunan Agricultural University, Changsha, PRChina.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D005075:Biological Evolution; D036022:Capsid Proteins / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D002681:China / Q000453:epidemiology; D018173:Circoviridae Infections / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D004279:DNA, Viral / Q000235:genetics; D014644:Genetic Variation; D016679:Genome, Viral; D005838:Genotype; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D015995:Prevalence; D054730:Protein Interaction Domains and Motifs; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; D004279:DNA, Viral; D014765:Viral Vaccines