title: Bloodstream infections in the Intensive Care Unit.
abstract: Bloodstream infections (BSIs) represent a common complication among critically ill patients and a leading cause of morbidity and mortality. The prompt initiation of an effective antibiotic therapy is necessary in order to reduce mortality and to improve clinical outcomes. However, the choice of the empiric antibiotic regimen is often challenging, due to the worldwide spread of multi-drug resistant (MDR) organisms with reduced susceptibility to the available broad-spectrum antimicrobials. New therapeutic strategies are 5 to improve the effectiveness of antibiotic treatment while minimizing the risk of resistance selection.
authors.affiliation: a Infectious Diseases Division, Santa Maria Misericordia Hospital , Udine , Italy.|b Clinica Malattie Infettive, Azienda Ospedaliera Universitaria Santa Maria della Misericordia , Udine , Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bassetti
authors.affiliation: a Infectious Diseases Division, Santa Maria Misericordia Hospital , Udine , Italy.|b Clinica Malattie Infettive, Azienda Ospedaliera Universitaria Santa Maria della Misericordia , Udine , Italy.
authors.forename: Elda
authors.initials: E
authors.lastname: Righi
authors.affiliation: a Infectious Diseases Division, Santa Maria Misericordia Hospital , Udine , Italy.|b Clinica Malattie Infettive, Azienda Ospedaliera Universitaria Santa Maria della Misericordia , Udine , Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Carnelutti
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000453:epidemiology* / Q000517:prevention & control; D062905:Central Venous Catheters / Q000382:microbiology; D003141:Communicable Diseases / Q000188:drug therapy / Q000382:microbiology / Q000635:transmission; D016638:Critical Illness / Q000453:epidemiology; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D017576:Daptomycin / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007362:Intensive Care Units
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin
keywords: antimicrobial resistance; bloodstream infections; central venous catheter; combination therapy;daptomycin; de-escalation; empiric therapy; intensive care unit