title: Prediction of patient-specific post-operative outcomes of TAVI procedure: The impact of the positioning strategy on valve performance.
abstract: Prosthesis positioning in transcatheter aortic valve implantation procedures represents a crucial aspect for procedure success as demonstrated by many recent studies on this topic. Possible complications, device performance, and, consequently, also long-term durability are highly affected by the adopted prosthesis placement strategy. In the present work, we develop a computational finite element model able to predict device-specific and patient-specific replacement procedure outcomes, which may help medical operators to plan and choose the optimal implantation strategy. We focus in particular on the effects of prosthesis implantation depth and release angle. We start from a real clinical case undergoing Corevalve self-expanding device implantation. Our study confirms the crucial role of positioning in determining valve anchoring, replacement failure due to intra or para-valvular regurgitation, and post-operative device deformation.
authors.affiliation: Dip. di Ingegneria Industriale e dell׳Informazione, Università di Pavia, Pavia, Italy. Electronic address: simone.morganti@unipv.it.
authors.forename: S
authors.initials: S
authors.lastname: Morganti
authors.affiliation: ICSA Policlinico Sant׳Ambrogio, Milano, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Brambilla
authors.affiliation: Ospedale Cisanello, Pisa, Italy.
authors.forename: A S
authors.initials: AS
authors.lastname: Petronio
authors.affiliation: Dip. di Ingegneria Civile e Architettura, Università di Pavia, Pavia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Reali
authors.affiliation: ICSA Policlinico Sant׳Ambrogio, Milano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bedogni
authors.affiliation: Dip. di Ingegneria Civile e Architettura, Università di Pavia, Pavia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Auricchio
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000601:surgery; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D066230:Patient-Specific Modeling; D011184:Postoperative Period; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D016896:Treatment Outcome
keywords: Finite element analysis; Patient-specific modeling; TAVI