title: Role of Collagen Gene Polymorphisms in the Structure of Early Gestation Loss.
abstract: Studies of collagen gene polymorphisms associated with predisposition to early recurrent miscarriages revealed significant differences in the distribution of COL1A1 C-1997A C>A (rs1107946) genotypes and alleles in the group of pregnant patients with early miscarriages in comparison with controls (normal pregnancy). Identification of COL1A1 C-1997A C>A (rs1107946) collagen gene polymorphisms at the stage of pregnancy planning will make it possible to form early miscarriage risk groups for more thorough preparation to gestation and optimization of follow up of this patient population.
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia. alegina1@rambler.ru.
authors.forename: E V
authors.initials: EV
authors.lastname: Alegina
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: N K
authors.initials: NK
authors.lastname: Tetruashvili
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Agadzhanova
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: D Yu
authors.initials: DY
authors.lastname: Trofimov
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Donnikov
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D003094:Collagen / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy
chemical_list: D003094:Collagen
keywords: collagen; gene polymorphism; pregnancy; recurrent miscarriage