title: Metabolomics in multiple sclerosis.
abstract: Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system with inflammatory and degenerative components. The cause of MS remains unknown although genetic and environmental factors appear to play a role in its etiopathogenesis. Metabolomics is a new "omics" technology that aims at measuring small molecules in various biological matrices and can provide information that is not readily obtained from genomics, transcriptomics, or proteomics. Currently, several different analytical platforms exist for metabolomics, and both untargeted and targeted approaches are being employed. Methods of analysis of metabolomics data are also being developed and no consensus currently exists on the optimal approach to analysis and interpretation of these data. Metabolomics has the potential to provide putative biomarkers, insights into the pathophysiology of the disease, and to aid in precision medicine for patients with MS.
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Pavan
authors.initials: P
authors.lastname: Bhargava
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA calabresi@jhmi.edu.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Calabresi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D055432:Metabolomics / Q000379:methods; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D057188:Workflow
chemical_list: D015415:Biomarkers
keywords: Metabolomics; biomarkers; mass spectrometry; multiple sclerosis; nuclear magnetic resonance