title: Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide.
abstract: A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle. The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.
authors.affiliation: School of Food and Pharmaceutical Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, 430068 Wuhan, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Ke
authors.affiliation: School of Food and Pharmaceutical Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, 430068 Wuhan, People's Republic of China. honghaosuncn@gmail.com.
authors.forename: Honghao
authors.initials: H
authors.lastname: Sun
authors.affiliation: School of Food and Pharmaceutical Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, 430068 Wuhan, People's Republic of China.
authors.forename: Mingxing
authors.initials: M
authors.lastname: Liu
authors.affiliation: School of Food and Pharmaceutical Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, 430068 Wuhan, People's Republic of China.
authors.forename: Zhengding
authors.initials: Z
authors.lastname: Su
authors.affiliation: School of Food and Pharmaceutical Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, 430068 Wuhan, People's Republic of China.
authors.forename: Kanghong
authors.initials: K
authors.lastname: Hu
authors.affiliation: School of Food and Pharmaceutical Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, 430068 Wuhan, People's Republic of China.
authors.forename: Hongda
authors.initials: H
authors.lastname: Zhua
authors.affiliation: School of Food and Pharmaceutical Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, 430068 Wuhan, People's Republic of China.
authors.forename: Huilin
authors.initials: H
authors.lastname: Guo
authors.affiliation: School of Food and Pharmaceutical Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, 430068 Wuhan, People's Republic of China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department for Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, 2800 Lyngby, Denmark.
authors.forename: Thomas Lars
authors.initials: TL
authors.lastname: Andresen
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
authors.forename: Lars Folke
authors.initials: LF
authors.lastname: Olsen
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology
chemical_list: D057846:Cell-Penetrating Peptides; D005456:Fluorescent Dyes; D009842:Oligopeptides; C448619:octaarginine