title: Motor unit number index (MUNIX): Is it relevant in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)?
abstract: OBJECTIVE
  To determine the test-retest reliability of motor unit number index (MUNIX) technique and to explore if the MUNIX sumscore could be related with disability in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
  
  
  METHODS
  The MUNIX technique was unilaterally assessed in the abductor digiti mini (ADM), the abductor pollicis brevi (APB) and the tibialis anterior (TA) muscles two different times by two blinded examiners. The MUNIX sumscore was calculated by adding the results of the ADM, APB and TA muscles.
  
  
  RESULTS
  14 CIDP patients were enrolled. The intraclass correlation coefficient (ICC) was great for inter and intra variability for ADM muscles (0.8 and 0.81), TA muscles (0.86 and 0.89) and MUNIX sumscore (0.76 and 0.83). The MUNIX sumscores from the first and second evaluations were strongly correlated (r=0.83, p<0.001). The MUNIX sumscore was significantly correlated with MRC testing (r=0.71, p<0.01), overall neuropathy limitation scale (ONLS) (r=-0.70, p<0.001), rasch-built overall disability scale (R-ODS) (r=0.71, p<0.001).
  
  
  CONCLUSIONS
  The MUNIX technique has a good reproducibility and the MUNIX sumscore is related to the disability.
  
  
  CONCLUSIONS
  The MUNIX technique estimates the axonal loss and the number of functional motor units. The MUNIX sumscore may be a good instrument to evaluate the CIDP patients during their follow-up.
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France; Aix-Marseille University, UMR 7286, Medicine Faculty, Marseille, France. Electronic address: emilien.delmont@ap-hm.fr.
authors.forename: Emilien
authors.initials: E
authors.lastname: Delmont
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France.
authors.forename: Agnes
authors.initials: A
authors.lastname: Benvenutto
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France.
authors.forename: Stephan
authors.initials: S
authors.lastname: Grimaldi
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France.
authors.forename: Laureline
authors.initials: L
authors.lastname: Duprat
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France.
authors.forename: Manon
authors.initials: M
authors.lastname: Philibert
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Pouget
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France.
authors.forename: Aude-Marie
authors.initials: AM
authors.lastname: Grapperon
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France; Aix Marseille Université - Inserm UMR S 910, Medical Genetics and Functional Genomics, Marseille, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Salort-Campana
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Sévy
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France.
authors.forename: Annie
authors.initials: A
authors.lastname: Verschueren
authors.affiliation: Referral Center for ALS and Neuromuscular Diseases, Timone University Hospital, Aix-Marseille University, France; Aix Marseille Université - Inserm UMR S 910, Medical Genetics and Functional Genomics, Marseille, France.
authors.forename: Shahram
authors.initials: S
authors.lastname: Attarian
mesh_terms: D000368:Aged; D004576:Electromyography / Q000379:methods / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis* / Q000503:physiopathology*; D011999:Recruitment, Neurophysiological / Q000502:physiology*; D016037:Single-Blind Method
keywords: CIDP; Disability; MUNIX; Test-retest reliability