title: Recent developments of 2-aminothiazoles in medicinal chemistry.
abstract: The 2-aminothiazole (2-AT) core is an active pharmacophore and used in medicinal chemistry and drug discovery research. A number of drugs with 2-AT core are in the market, e.g. Famotidine, Cefdinir, Meloxcam etc. Recently, 2-AT core has been explored for many more important therapeutic areas and identified new 2-aminothiazoles with anticancer, antitumor, antidiebatic and anticonvulsant activity. In this review, we discuss the newly identified and developed 2-aminothiazoles in recent years and their use in medicinal chemistry and pharmacology.
authors.affiliation: Post Graduate Department of Chemistry, Sree Chaitanya College, Habra, 24 Parganas 743268, India. Electronic address: debasisdas@chemconfidence.com.
authors.forename: Debasis
authors.initials: D
authors.lastname: Das
authors.affiliation: Post Graduate Department of Chemistry, Sree Chaitanya College, Habra, 24 Parganas 743268, India.
authors.forename: Papiya
authors.initials: P
authors.lastname: Sikdar
authors.affiliation: Post Graduate Department of Chemistry, Sree Chaitanya College, Habra, 24 Parganas 743268, India.
authors.forename: Moumita
authors.initials: M
authors.lastname: Bairagi
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D007004:Hypoglycemic Agents; D018696:Neuroprotective Agents; D013844:Thiazoles; C004483:2-aminothiazole
keywords: 2-Aminothiazole; Bioactive; Drugs; Medicinal chemistry; Pharmacological activity; Review; Thiazole