title: Interplay between oxidant species and energy metabolism.
abstract: It has long been recognized that energy metabolism is linked to the production of reactive oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by redox reactions. This interplay between energy metabolism and ROS becomes most apparent during the aging process and in the onset and progression of many age-related diseases (i.e. diabetes, metabolic syndrome, atherosclerosis, neurodegenerative diseases). As such, the capacity to identify metabolic pathways involved in ROS formation, as well as specific targets and oxidative modifications is crucial to our understanding of the molecular basis of age-related diseases and for the design of novel therapeutic strategies. Herein we review oxidant formation associated with the cell's energetic metabolism, key antioxidants involved in ROS detoxification, and the principal targets of oxidant species in metabolic routes and discuss their relevance in cell signaling and age-related diseases.
authors.affiliation: Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Av. General Flores 2125, CP 11800 Montevideo, Uruguay. Electronic address: celiq@fmed.edu.uy.
authors.forename: Celia
authors.initials: C
authors.lastname: Quijano
authors.affiliation: Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Av. General Flores 2125, CP 11800 Montevideo, Uruguay.
authors.forename: Madia
authors.initials: M
authors.lastname: Trujillo
authors.affiliation: Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Av. General Flores 2125, CP 11800 Montevideo, Uruguay.
authors.forename: Laura
authors.initials: L
authors.lastname: Castro
authors.affiliation: Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Av. General Flores 2125, CP 11800 Montevideo, Uruguay. Electronic address: trocha@fmed.edu.uy.
authors.forename: Andrés
authors.initials: A
authors.lastname: Trostchansky
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002952:Citric Acid Cycle; D045222:Electron Transport Chain Complex Proteins / Q000378:metabolism; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D053858:Metabolic Networks and Pathways; D008928:Mitochondria / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D047495:PPAR gamma / Q000378:metabolism; D011687:Purines / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D045222:Electron Transport Chain Complex Proteins; D005227:Fatty Acids; D016877:Oxidants; D047495:PPAR gamma; D011687:Purines; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; C030985:purine
keywords: Energy metabolism; Mitochondria; Reactive nitrogen species; Reactive oxygen species