title: Functional lateralization in cingulate cortex predicts motor recovery after basal ganglia stroke.
abstract: The basal ganglia (BG) is involved in higher order motor control such as movement planning and execution of complex motor synergies. Neuroimaging study on stroke patients specifically with BG lesions would help to clarify the consequence of BG damage on motor control. In this paper, we performed a longitudinal study in the stroke patients with lesions in BG regions across three motor recovery stages, i.e., less than 2week (Session 1), 1-3m (Session 2) and more than 3m (Session 3). The patients showed an activation shift from bilateral hemispheres during early sessions (<3m) to the ipsilesional cortex in late session (>3m), suggesting a compensation effect from the contralesional hemisphere during motor recovery. We found that the lateralization of cerebellum(CB) for affected hand task correlated with patients' concurrent Fugl-Meyer index (FMI) in Session 2. Moreover, the cingulate cortex lateralization index in Session 2 was shown to significantly correlate with subsequent FMI change between Session 3 and Session 2, which serves as a prognostic marker for motor recovery. Our findings consolidated the close interactions between BG and CB during the motor recovery after stroke. The dominance of activation in contralateral cingulate cortex was associated with a better motor recovery, suggesting the important role of ipsilesional attention modulation in the early stage after BG stroke.
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: chenzengai@163.com.
authors.forename: Zengai
authors.initials: Z
authors.lastname: Chen
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Su
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Xiaoliu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China. Electronic address: shanbao.tong@gmail.com.
authors.forename: Shanbao
authors.initials: S
authors.lastname: Tong
mesh_terms: D000368:Aged; D020144:Basal Ganglia Cerebrovascular Disease / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009048:Motor Skills; D059906:Neuroimaging; D020521:Stroke / Q000503:physiopathology*; D000071939:Stroke Rehabilitation
keywords: Basal ganglia; Cerebellum; Cingulate cortex; Lateralization; fMRI