title: Incidence and mortality of postoperative acute kidney injury in non-dialysis patients: comparison between the AKIN and KDIGO criteria.
abstract: OBJECTIVE
  This retrospective study determines whether the kidney disease: improving global outcomes (KDIGO) criteria are superior to acute kidney injury network (AKIN) criteria in detecting non-dialysis AKI events and predicting mortality in chronic kidney disease (CKD) patients after surgery.
  
  
  METHODS
  Surgical patients who were admitted to the intensive care unit were enrolled. Non-dialysis AKI cases were defined using either KDIGO or AKIN creatinine criteria and stratified by CKD stages. The adjusted hazard ratios (AHRs) for in-hospital mortality are compared to those without AKI. The cumulative survival curves and the predictability for mortality are accessed by Kaplan-Meier method and calculating the area under the curve (AUC) for the receiver operating characteristic (ROC) curve, respectively.
  
  
  RESULTS
  From a total of 826 postoperative patients, the overall in-hospital mortality rate was 11.6% (96 cases) and that for AKI according to KDIGO and AKIN criteria was 30.0% (248 cases) and 31.0% (256 cases). The cumulative survival curve stratified by CKD and AKI stages were comparable between KDIGO and AKIN criteria. The discriminative power for mortality stratified by CKD stages for KDIGO and AKIN criteria are as followed: all subjects: 0.678 versus 0.670 (both ps <0.001); non-CKD: 0.800 versus 0.809 (both ps <0.001); early-stage CKD: 0.676 versus 0.676 (both ps <0.001); late-stage CKD: 0.674 versus 0.660 (ps were <0.001 and 0.003).
  
  
  CONCLUSIONS
  The KDIGO criteria are superior to AKIN criteria in predicting mortality after surgery, especially in those with advanced CKD.
authors.affiliation: a Division of Nephrology, Department of Internal Medicine , Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan , Taiwan ;|b College of Nursing, Chang Gung University of Science and Technology , Taoyuan , Taiwan ;
authors.forename: Hung-Chieh
authors.initials: HC
authors.lastname: Wu
authors.affiliation: c Department of Physical Medicine and Rehabilitation , Cheng Hsin General Hospital , Taipei , Taiwan ;
authors.forename: Lin-Chien
authors.initials: LC
authors.lastname: Lee
authors.affiliation: a Division of Nephrology, Department of Internal Medicine , Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan , Taiwan ;|b College of Nursing, Chang Gung University of Science and Technology , Taoyuan , Taiwan ;|d Department of Biomedical Engineering , Chung Yuan Christian University , Taoyuan , Taiwan.
authors.forename: Wei-Jie
authors.initials: WJ
authors.lastname: Wang
mesh_terms: D058186:Acute Kidney Injury / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology*; D000368:Aged; D005260:Female; D005440:Fluid Therapy; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies
keywords: Acute kidney injury; acute kidney injury network criteria; chronic kidney disease; kidney disease: improving global outcomes criteria; mortality