title: Antibiotic loaded carboxymethylcellulose/MCM-41 nanocomposite hydrogel films as potential wound dressing.
abstract: Existing wound dressings have disadvantages such as lack of antibacterial activity, insufficient oxygen and water vapor permeability, and poor mechanical properties. Hydrogel-based wound dressings swell several times their dry volume and would be helpful to absorb wound exudates and afford a cooling sensation and a moisture environment. To overcome these hassles, a novel antibiotic-eluting nanocomposite hydrogel was designed via incorporation of mesoporous silica MCM-41 as a nano drug carrier into carboxymethylcellulose hydrogel. Tetracycline and methylene blue as antibacterial agents were loaded to the system and showed different release profiles. The prepared nanocomposite hydrogel was characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), UV-vis spectroscopy, and scanning electron microscopy (SEM). The prepared nanocomposite hydrogels exhibited an enhanced in vitro swelling, erosion, water vapor and oxygen permeability, and antimicrobial activity. This could effectively increase the time intervals needed to exchange the bandage. The obtained data strongly encourage the use of these nanocomposite hydrogels as wound dressing material.
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran; Research Center for Pharmaceutical Nanonotechnology, Tabriz University of Medical Science, Tabriz, Iran. Electronic address: namazi@tabrizu.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Namazi
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
authors.forename: Rasul
authors.initials: R
authors.lastname: Rakhshaei
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Hamishehkar
authors.affiliation: Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hossein Samadi
authors.initials: HS
authors.lastname: Kafil
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001684:Biological Dressings; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D065546:Drug Liberation; D020100:Hydrogels; D008756:Methylgalactosides / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010100:Oxygen / Q000737:chemistry; D010539:Permeability; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013227:Steam; D014945:Wound Healing; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D020100:Hydrogels; C509968:MCM-41; D008756:Methylgalactosides; D013227:Steam; C109801:hydrogel film; D012822:Silicon Dioxide; D002266:Carboxymethylcellulose Sodium; D010100:Oxygen
keywords: Antibacterial; Controlled released; Hydrogel; Mesoporous silica; Wound healing