title: Autotaxin-LPA receptor axis in the pathogenesis of lung diseases.
abstract: Lysophosphatidic acid (LPA) is a small lipid which mediates a variety of cellular functions via the activation of LPA receptors. LPA is generated from lysophosphatidylcholine by the extracellular enzyme, autotaxin (ATX). Elevated ATX expression, LPA production and their signaling pathways have been reported in multiple pathological conditions of lung tissue, including inflammation, fibrosis and cancer. Emerging evidence has highlighted the importance of ATX and LPA receptors in the pathogenesis of lung diseases. Here, we briefly review the current knowledge of different roles of the ATX-LPA receptor axis in lung diseases focusing on inflammation, fibrosis and cancer.
authors.affiliation: People's Hospital of Rizhao Rizhao, Shandong, China.
authors.forename: Xiangpeng
authors.initials: X
authors.lastname: Chu
authors.affiliation: People's Hospital of Rizhao Rizhao, Shandong, China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Wei
authors.affiliation: People's Hospital of Rizhao Rizhao, Shandong, China.
authors.forename: Shaolin
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Internal Medicine, Emory University Atlanta, Georgia, USA.
authors.forename: Peijian
authors.initials: P
authors.lastname: He
keywords: Lysophosphatidic acid receptor; autotaxin; lung diseases