title: Current Treatment Modalities of JIA-associated Uveitis and its Complications: Literature Review.
abstract: Uveitis is a common and serious complication of juvenile idiopathic arthritis. Up to 75% of all cases of anterior uveitis in childhood are associated with juvenile idiopathic arthritis. Despite the remarkable progress in early detection and treatment of inflammation, vision-threatening complications of uveitis still occur in almost 60% of patients. Structural complications include band keratopathy, maculopathy (macular edema, macular cysts, and epiretinal membrane), glaucomatous optic neuropathy, and cataracts. The management of complications in juvenile idiopathic arthritis is usually complex and requires early surgical intervention. In this paper, we review the general concepts of common ocular complications seen in patients with JIA-associated uveitis, with special attention to the recent diagnostic and preferred treatment approaches at the Massachusetts Eye Research and Surgery Institution. Received 9 March 2015; revised 30 September 2015; accepted 30 October 2015; published online 14 January 2016.
authors.affiliation: a Massachusetts Eye Research and Surgery Institution (MERSI) , Waltham , Massachusetts , USA.|b Ocular Immunology and Uveitis Foundation (OIUF) , Waltham , Massachusetts , USA.
authors.forename: Khawla
authors.initials: K
authors.lastname: Abu Samra
authors.affiliation: a Massachusetts Eye Research and Surgery Institution (MERSI) , Waltham , Massachusetts , USA.|b Ocular Immunology and Uveitis Foundation (OIUF) , Waltham , Massachusetts , USA.|c Department of Ophthalmology , Scheie Eye Institute, University of Pennsylvania School of Medicine , Philadelphia , Pennsylvania , USA.|d Harvard Medical School , Cambridge , Massachusetts , USA.
authors.forename: Armin
authors.initials: A
authors.lastname: Maghsoudlou
authors.affiliation: a Massachusetts Eye Research and Surgery Institution (MERSI) , Waltham , Massachusetts , USA.|b Ocular Immunology and Uveitis Foundation (OIUF) , Waltham , Massachusetts , USA.|e Department of Ophthalmology , Farabi Eye Hospital , Tehran , Iran.|f Eye Research Centre , Tehran University of Medical Sciences , Tehran , Iran.|g Massachusetts Eye and Ear Infirmary , Cambridge , Massachusetts , USA.
authors.forename: Ramak
authors.initials: R
authors.lastname: Roohipoor
authors.affiliation: a Massachusetts Eye Research and Surgery Institution (MERSI) , Waltham , Massachusetts , USA.|b Ocular Immunology and Uveitis Foundation (OIUF) , Waltham , Massachusetts , USA.
authors.forename: Manuel
authors.initials: M
authors.lastname: Valdes-Navarro
authors.affiliation: a Massachusetts Eye Research and Surgery Institution (MERSI) , Waltham , Massachusetts , USA.|b Ocular Immunology and Uveitis Foundation (OIUF) , Waltham , Massachusetts , USA.
authors.forename: Stacey
authors.initials: S
authors.lastname: Lee
authors.affiliation: a Massachusetts Eye Research and Surgery Institution (MERSI) , Waltham , Massachusetts , USA.|b Ocular Immunology and Uveitis Foundation (OIUF) , Waltham , Massachusetts , USA.|d Harvard Medical School , Cambridge , Massachusetts , USA.|g Massachusetts Eye and Ear Infirmary , Cambridge , Massachusetts , USA.
authors.forename: C Stephen
authors.initials: CS
authors.lastname: Foster
mesh_terms: D001171:Arthritis, Juvenile / Q000150:complications*; D042241:Early Diagnosis; D006801:Humans; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D014792:Visual Acuity / Q000502:physiology
keywords: Chronic JIA-associated uveitis; complication; corticosteroid; review; treatment