title: Multiple Myeloma: Diagnosis and Treatment.
abstract: The diagnosis and treatment of multiple myeloma has changed dramatically in the past decade. The disease definition has been updated to include highly specific biomarkers in addition to established markers of end-organ damage. The staging system has been revised to combine both measures of tumor burden and disease biology. Advances in therapy have resulted in a marked improvement in overall survival. New drugs introduced in the past few years include carfilzomib, pomalidomide, panobinostat, ixazomib, elotuzumab, and daratumumab. In this review, we outline the current approach to the diagnosis, prognosis, and management of multiple myeloma.
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN. Electronic address: rajkumar.vincent@mayo.edu.
authors.forename: S Vincent
authors.initials: SV
authors.lastname: Rajkumar
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN.
authors.forename: Shaji
authors.initials: S
authors.lastname: Kumar
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000145:classification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000145:classification / Q000494:pharmacology; D019468:Disease Management; D006801:Humans; D009101:Multiple Myeloma / Q000175:diagnosis / Q000628:therapy; D009194:Myeloma Proteins / Q000032:analysis; D011379:Prognosis; D047368:Tumor Burden
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D009194:Myeloma Proteins