title: In vitro antimicrobial susceptibility of Alloscardovia omnicolens and molecular mechanisms of acquired resistance.
abstract: All the 31 isolates of Alloscardovia omnicolens exhibited low MICs for β-lactams, glycopeptides, linezolid, tetracyclines, and cotrimoxazole. One strain showed MICs ≥256μg/mL for both erythromycin and clindamycin with a single point mutation in 23S rRNA. One strain likely had acquired fluoroquinolone resistance associated with a unique mutation in ParC.
authors.affiliation: CHU de Caen, Service de Microbiologie, F-14033 Caen, France; Université de Caen Basse-Normandie, EA4655 (équipe "Antibiorésistance"), F-14032 Caen, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Isnard
authors.affiliation: Laboratoire ADMED, CH-2300 La-Chaux-de-Fonds, Switzerland.
authors.forename: Reto
authors.initials: R
authors.lastname: Lienhard
authors.affiliation: CHU de Caen, Service de Microbiologie, F-14033 Caen, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Reissier
authors.affiliation: Laboratoire ADMED, CH-2300 La-Chaux-de-Fonds, Switzerland.
authors.forename: Sonia
authors.initials: S
authors.lastname: Rodriguez
authors.affiliation: CH de Bienne, Service de Médecine Interne, CH-2502 Bienne, Switzerland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Krähenbühl
authors.affiliation: Laboratoire DIANALABS, CH-1205 Geneva, Switzerland.
authors.forename: Nadia
authors.initials: N
authors.lastname: Liassine
authors.affiliation: CHU de Caen, Service de Microbiologie, F-14033 Caen, France; Université de Caen Basse-Normandie, EA4655 (équipe "Antibiorésistance"), F-14032 Caen, France; CNR de la Résistance aux Antibiotiques, Laboratoire Associé "Entérocoques et résistances particulières des bactéries à Gram positif", F-14033 Caen, France.
authors.forename: François
authors.initials: F
authors.lastname: Guérin
authors.affiliation: CHU de Caen, Service de Microbiologie, F-14033 Caen, France; Université de Caen Basse-Normandie, EA4655 (équipe "Antibiorésistance"), F-14032 Caen, France; CNR de la Résistance aux Antibiotiques, Laboratoire Associé "Entérocoques et résistances particulières des bactéries à Gram positif", F-14033 Caen, France. Electronic address: cattoir-v@chu-caen.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Cattoir
mesh_terms: D039903:Actinobacteria / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D024881:Drug Resistance, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D012338:RNA, Ribosomal, 23S / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D000900:Anti-Bacterial Agents; D012338:RNA, Ribosomal, 23S
keywords: 23S rRNA mutation; A. omnicolens; Fluoroquinolone resistance; Macrolide resistance; QRDR; parC mutation