title: Recombination of Correlations between Bioelements in the Liver and Lungs during Modeling of Diet-Induced Obesity.
abstract: In rats with obesity induced by high fat ration, the concentrations of K, Ca, Mn, Fe, Cu, Zn, Se, Br, Rb, and Sr were measured in the liver and lungs using synchrotron X-ray fluorescence analysis. Recombinations of inter-element correlations in the liver and lungs of rats receiving or not receiving additional Zn were observed under fasting conditions and after eating lard. Sr and Ca made the most pronounced contribution in the redistribution of correlations in the liver of obese rats. In contrast to other bioelements, Sr had negative correlations with all study elements in the liver of obese rats during physiological starvation. Long-term administration of Zn to rats was followed by recombination of both fasting and postprandial inert-element correlations in the liver and lungs, but Zn concentration did not change under these conditions. Redistribution of correlations in the liver and lungs of obese rats under fasting conditions reflects fundamental changes in metabolic processes, while redistribution observed after fat meal indicates temporary (postprandial) changes.
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Moscow, Russia. pathol@inbox.ru.
authors.forename: B V
authors.initials: BV
authors.lastname: Churin
authors.affiliation: A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Division of the Russian Academy of Sciences, Moscow, Russia.|Novosibirsk National Research State University, Novosibirsk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Trunova
authors.affiliation: A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Division of the Russian Academy of Sciences, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Sidorina
authors.affiliation: A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Division of the Russian Academy of Sciences, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Zvereva
authors.affiliation: Research Institute of Chemical Diversity, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Astashov
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Moscow, Russia.
authors.forename: V K
authors.initials: VK
authors.lastname: Preobrazhenskaya
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Moscow, Russia.
authors.forename: R A
authors.initials: RA
authors.lastname: Manvelidze
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D004195:Disease Models, Animal; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000494:pharmacology
chemical_list: D015032:Zinc
keywords: alimentary obesity liver; bioelements; lungs; synchrotron X-ray fluorescence analysis