title: Ircinal E, a New Manzamine Derivative from the Indonesian Marine Sponge Acanthostrongylophora ingens.
abstract: Chemical investigation of the MeOH extract of the sponge Acanthostrongylophora ingens afforded the new manzamine derivative ircinal E (1), in addition to six known metabolites (2-7). The structure of the new compound was unequivocally elucidated using one- and two-dimensional NMR spectroscopy, as well as high-resolution mass spectrometry. Compounds 1-6 exhibited strong to moderate cytotoxicity against the murine lymphoma L5178Y cell line with IC50 values ranging from 2.8 to 21.7 µM.
authors.forename: Mousa
authors.initials: M
authors.lastname: AlTarabeen
authors.forename: Georgios
authors.initials: G
authors.lastname: Daletos
authors.forename: Weaam
authors.initials: W
authors.lastname: Ebrahim
authors.forename: Werner E G
authors.initials: WE
authors.lastname: Müller
authors.forename: Rudolf
authors.initials: R
authors.lastname: Hartmann
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D002227:Carbazoles / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
chemical_list: D002227:Carbazoles; C041514:carbazole