title: In-Stent Restenosis Caused by a Calcified Nodule: A Novel Pattern of Neoatherosclerosis.
abstract: Neoatherosclerosis has been described as a cause of in-stent restenosis (ISR), particularly in patients treated with drug-eluting stents (DESs). Although neoatherosclerosis may present as calcified plaques, the occurrence of a "calcified nodule" within the stent has not been previously reported. We describe optical coherence tomographic findings in a patient presenting with a calcified nodule causing "undilatable" ISR 2 years after implantation of a DES. The clinical and technical implications of this novel pattern of neoatherosclerosis are discussed.
authors.affiliation: Hospital Universitario de La Princesa, Madrid, Spain. Electronic address: falf@hotmail.com.
authors.forename: Fernando
authors.initials: F
authors.lastname: Alfonso
authors.affiliation: Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Cuesta
authors.affiliation: Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Bastante
authors.affiliation: Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: María Cruz
authors.initials: MC
authors.lastname: Aguilera
authors.affiliation: Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: Amparo
authors.initials: A
authors.lastname: Benedicto
authors.affiliation: Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivero
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000628:therapy; D023903:Coronary Restenosis / Q000209:etiology* / Q000628:therapy; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D058426:Neointima / Q000473:pathology; D012307:Risk Factors; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods; D016896:Treatment Outcome