title: Short-interval two-stage approach to primary total knee arthroplasty for acutely septic osteoarthritic knees.
abstract: Treatment strategies for advanced knee osteoarthritis with coexistent joint infection are not well established. While in periprosthetic joint infection the two-stage approach has been studied extensively, only few case reports on two-stage total knee arthroplasty (TKA) for knee osteoarthritis with coexistent joint infection have been published. The purpose of this paper was to report on our method of implementing a two-stage TKA with intervening antibiotic-loaded articulating cement spacers and a short interval between first- and second-stage procedures to treat two patients with Staphylococcus aureus-infected end-stage knee osteoarthritis. Consistent infection eradication was found at a 1-year follow-up with postoperative range of motion and knee scores comparing favourably with those of other case series. Level of evidence V.
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Cantonal Hospital St. Gallen, 9007, St. Gallen, Switzerland.
authors.forename: Bettina
authors.initials: B
authors.lastname: Hochreiter
authors.affiliation: Department of Infectious Diseases and Infection Control, Cantonal Hospital St. Gallen, 9007, St. Gallen, Switzerland.
authors.forename: Carol
authors.initials: C
authors.lastname: Strahm
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Cantonal Hospital St. Gallen, 9007, St. Gallen, Switzerland. henrik.behrend@kssg.ch.
authors.forename: Henrik
authors.initials: H
authors.lastname: Behrend
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001170:Arthritis, Infectious / Q000382:microbiology / Q000601:surgery*; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D001843:Bone Cements; D016503:Drug Delivery Systems; D006801:Humans; D007719:Knee Joint / Q000382:microbiology / Q000601:surgery; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000601:surgery*; D016059:Range of Motion, Articular; D013203:Staphylococcal Infections / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements
keywords: Knee; Septic osteoarthritis; Short interval; TKR; Total knee arthroplasty; Total knee replacement; Two-stage TKA