title: Hydatid cyst surgery complicated by hemorrhage resistant to activated recombinant factor VII, in a hemophiliac A patient with an inhibitor.
abstract: Factor VII is a new coagulation factor replacement therapy. It has permitted the practice of invasive procedures which were up until recently associated with a huge risk of bleeding in patients with hemophilia with inhibitors. Our case illustrates factor replacement therapy failure in a 13-year-old child operated on for hepatic cysts associated with a pelvic cyst. Major bleeding occurred postoperatively requiring several transfusions, an increase in dosage of factor VII, and administration of a heavy dose of factor VIII as a last resort. This case highlights the possibility of failure of factor replacement therapies constituting a life-threatening situation in which alternatives are few.
authors.affiliation: aFaculty of Medicine and Pharmacy, Mohammed V University bHematology and Pediatric Oncology Unit, Children's Hospital, Ibn Sina Hospital cPediatric Intensive Care Unit, Children's Hospital of Rabat, Rabat, Morocco.
authors.forename: Saad
authors.initials: S
authors.lastname: Nabil
authors.forename: Aziza
authors.initials: A
authors.lastname: Bentalha
authors.forename: Lamine
authors.initials: L
authors.lastname: Jaiteh
authors.forename: Mohammed
authors.initials: M
authors.lastname: El Khorassani
authors.forename: Alae
authors.initials: A
authors.lastname: El Koraichi
authors.forename: Salma E-C
authors.initials: SE
authors.lastname: El Kettani
mesh_terms: D000293:Adolescent; D001803:Blood Transfusion; D004443:Echinococcosis / Q000097:blood* / Q000150:complications / Q000469:parasitology / Q000601:surgery; D005169:Factor VIII / Q000627:therapeutic use*; D015942:Factor VIIa / Q000627:therapeutic use*; D006467:Hemophilia A / Q000097:blood* / Q000150:complications / Q000469:parasitology / Q000601:surgery; D006470:Hemorrhage / Q000097:blood / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D005169:Factor VIII; C103587:recombinant FVIIa; D015942:Factor VIIa