title: Effect of DA-9701 on the Normal Motility and Clonidine-induced Hypomotility of the Gastric Antrum in Rats.
abstract: OBJECTIVE
  DA-9701 is a novel prokinetic agent. In the present study, we investigated the effect of DA-9701 on the motility of the gastric antrum in the normal and clonidine-induced hypomotility in an in vivo animal model.
  
  
  METHODS
  A strain gauge force transducer was sutured on the gastric antrum to measure the contractile activity in rats. A total of 28 rats were subclassified into the 4 groups: (1) the placebo group, (2) the DA-9701 group, (3) the placebo group in the clonidine-pretreated rats, and (4) the DA-9701 group in the clonidine-pretreated rats. After the basal recording, either placebo (3% [w/v] hydroxypropylmethyl cellulose) or DA-9701 was administered. Contractile signals were measured after the administration and after a meal. In the clonidinepretreated rats, either placebo or DA-9701 was administered. Contractile signals were measured after the administration and after a meal.
  
  
  RESULTS
  Oral administration of DA-9701 did not significantly alter the motility index of the gastric antrum in the preprandial and postprandial periods, compared with the placebo group. The administration of clonidine decreased the motility index of the gastric antrum in the preprandial and postprandial periods, compared with the administration of placebo. This reduction of the antral motility by the administration of clonidine was not observed in the clonidine-pretreated DA-9701 group. The percentage of the motility index in the postprandial period was significantly greater in the clonidine-pretreated DA-9701 group, compared with the clonidine-pretreated placebo group.
  
  
  CONCLUSIONS
  DA-9701 improves the hypomotility of the gastric antrum induced by clonidine, suggesting its gastroprokinetic effect in the pathologic condition.
authors.affiliation: Department of Gastroenterology, Ajou University School of Medicine, Suwon, Gyeonggi-do, Korea.
authors.forename: Je Wook
authors.initials: JW
authors.lastname: Kang
authors.affiliation: Laboratory Animal Research Center, Ajou University School of Medicine, Suwon, Gyeonggi-do, Korea.
authors.forename: Dae Kyeong
authors.initials: DK
authors.lastname: Han
authors.affiliation: Laboratory Animal Research Center, Ajou University School of Medicine, Suwon, Gyeonggi-do, Korea.
authors.forename: Ock Nyun
authors.initials: ON
authors.lastname: Kim
authors.affiliation: Department of Gastroenterology, Ajou University School of Medicine, Suwon, Gyeonggi-do, Korea.
authors.forename: Kwang Jae
authors.initials: KJ
authors.lastname: Lee
keywords: Antrum; DA-9701; Motility; Prokinetic