title: Mitigating Effect of Resveratrol on the Structural Changes of Mice Liver and Kidney Induced by Cadmium; A Stereological Study.
abstract: Exposure to cadmium (Cd) has harmful effects on the liver and kidney. Resveratrol (RES) is an herbal substance that functions as a protective mediator. This study aimed to investigate the effects of RES on the histology of liver and kidney in Cd-exposed mice. Male mice were divided into 4 groups daily receiving normal saline (1 mL normal saline/d), Cd (1 mg/kg/d), RES (20 mg/kg/d), and Cd plus RES, respectively. After 4 weeks, the liver and kidney components were evaluated using stereological methods. The total volume and number of hepatocytes, and volume of fibrous tissue were respectively increased by 34%, 58%, and a 3-fold in the Cd-exposed mice in comparison to the control animals (P < 0.03). On the other hand, the volume of the main vasculature (sinusoids and central veins) was decreased by 36% in the Cd group compared to the control mice (P < 0.03). Considering the kidney, the results showed a 3-fold increase in the total glomeruli volume and a 7-fold increase in fibrous tissue in the Cd-treated group compared to the control mice (P < 0.03). After Cd treatment, a 32% reduction was observed in the volume and length of the proximal and distal convoluted tubules. RES-treatment alone did not induce any structural changes. In comparison to the Cd group, an increase in the normal components of the liver and kidney and a decrease in the formation of the fibrous and degenerated tissues were observed in the Cd+RES-treated mice (P < 0.03).
authors.affiliation: Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran; Physiology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Rafati
authors.affiliation: Department of Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Hoseini
authors.affiliation: Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Babai
authors.affiliation: Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran; Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Noorafshan
authors.affiliation: Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Haghbin
authors.affiliation: Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran; Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran.
authors.forename: Saied
authors.initials: S
authors.lastname: Karbalay-Doust
keywords: cadmium; kidney; liver; quantitative; resveratrol