title: Association of DENND1A Gene Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis.
abstract: OBJECTIVE
  The rs2479106 and rs10818854 polymorphisms in the DENND1A gene have been reported to be extensively associated with risk of polycystic ovary syndrome (PCOS). However, the results from these studies remained inconclusive and conflicting. To detect a true association of rs2479106 and rs10818854 polymorphisms with PCOS risk, a single study may be underpowered, particularly for those studies with inadequate sample size. Therefore, we performed a meta-analysis of all available studies to explore this association.
  
  
  METHODS
  All studies published up to March 2015 on the association were identified by searching electronic databases PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure. Studies containing available genotype frequencies of those 2 polymorphisms were chosen, and the odds ratios and associated 95% confidence intervals were calculated using fixed- or random- effects models.
  
  
  RESULTS
  A total of 8 studies about s2479106 polymorphism (8185 cases and 28675 controls) and 5 studies about rs10818854 polymorphism (6638 cases and 27443 controls) met the inclusion criteria for the meta-analysis. Overall, significant increase of PCOS risk was found between DENND1A-rs10818854 and PCOS susceptibility. In addition, we also found an increased risk of PCOS in rs2479106 allele model, heterozygote variant genetic model, and dominant genetic model.
  
  
  CONCLUSIONS
  This meta-analysis suggested that rs2479106 and rs10818854 polymorphisms in the DENND1A gene were associated with increased risk of PCOS. To validate the association between these polymorphisms and PCOS susceptibility, further large and well-designed studies are needed.
authors.forename: Shan
authors.initials: S
authors.lastname: Bao
authors.forename: Jun Hong
authors.initials: JH
authors.lastname: Cai
authors.forename: Shu Ying
authors.initials: SY
authors.lastname: Yang
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Ren
authors.forename: Tian
authors.initials: T
authors.lastname: Feng
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Hainan Provincial People's Hospital, Clinic of Gynecology and Obstetrics, Haikou, China Phone: 86-898-68622452 E-mail: zhuorili@126.com.
authors.forename: Zhuo Ri
authors.initials: ZR
authors.lastname: Li
mesh_terms: D053418:Death Domain Receptor Signaling Adaptor Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C571984:DENND1A protein, human; D053418:Death Domain Receptor Signaling Adaptor Proteins; D020662:Guanine Nucleotide Exchange Factors