title: Synthesis of cinnolines via Rh(iii)-catalysed dehydrogenative C-H/N-H functionalization: aggregation induced emission and cell imaging.
abstract: Rhodium catalysed dehydrogenative C-H/N-H functionalization was developed to construct phthalazino[2,3-a]-/indazolo[1,2-a]cinnolines by reacting N-phenyl phthalazine/indazole with alkynes. The synthesized compounds exhibit prominent fluorescence properties in solid and aggregation states. Their application in cell imaging was investigated using various cancer cell lines.
authors.affiliation: Organic & Bioorganic Chemistry, Council of Scientific and Industrial Research (CSIR)-CLRI, Chennai, 600020, India. ptperumal@gmail.com.
authors.forename: Sivakalai
authors.initials: S
authors.lastname: Mayakrishnan
authors.affiliation: Organic & Bioorganic Chemistry, Council of Scientific and Industrial Research (CSIR)-CLRI, Chennai, 600020, India. ptperumal@gmail.com.
authors.forename: Yuvaraj
authors.initials: Y
authors.lastname: Arun
authors.affiliation: Department of Hematology, Fujita Health University, Aichi 470-1192, Japan.
authors.forename: Chandrasekar
authors.initials: C
authors.lastname: Balachandran
authors.affiliation: Department of Hematology, Fujita Health University, Aichi 470-1192, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Emi
authors.affiliation: Organic & Bioorganic Chemistry, Council of Scientific and Industrial Research (CSIR)-CLRI, Chennai, 600020, India. ptperumal@gmail.com.
authors.forename: Doraiswamy
authors.initials: D
authors.lastname: Muralidharan
authors.affiliation: Organic & Bioorganic Chemistry, Council of Scientific and Industrial Research (CSIR)-CLRI, Chennai, 600020, India. ptperumal@gmail.com.
authors.forename: Paramasivan Thirumalai
authors.initials: PT
authors.lastname: Perumal
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D045744:Cell Line, Tumor; D002470:Cell Survival; D005453:Fluorescence; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D006865:Hydrogenation; D007191:Indazoles / Q000737:chemistry; D008958:Models, Molecular; D057054:Molecular Imaging; D015394:Molecular Structure; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D010793:Phthalazines / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006574:Heterocyclic Compounds, 2-Ring; D007191:Indazoles; D009942:Organometallic Compounds; D010793:Phthalazines; D012238:Rhodium; C476282:cinnoline