title: Cytisine-type alkaloids and flavonoids from the rhizomes of Sophora tonkinensis.
abstract: A new cytisine-type alkaloid, (-)-N-hexanoylcytisine (1), and a new isoflavan, (3S, 4R)-4-hydroxy-7,4'-dimethoxyisoflavan 3'-O-β-d-glucopyranoside (2), along with 10 known compounds, were isolated from the rhizomes of Sophora tonkinensis. Their structures were determined by spectroscopic methods, chemical evidence, and ECD data analysis. All of the isolates were evaluated for their cytotoxic activities against four human tumor cell lines.
authors.affiliation: a State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences , Guangxi Normal University , Guilin 541004 , China.
authors.forename: Qi-Ming
authors.initials: QM
authors.lastname: Pan
authors.affiliation: b College of Pharmacy , Guilin Medical University , Guilin 541004 , China.
authors.forename: Gui-Jie
authors.initials: GJ
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences , Guangxi Normal University , Guilin 541004 , China.
authors.forename: Ri-Zhen
authors.initials: RZ
authors.lastname: Huang
authors.affiliation: a State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences , Guangxi Normal University , Guilin 541004 , China.
authors.forename: Ying-Ming
authors.initials: YM
authors.lastname: Pan
authors.affiliation: a State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences , Guangxi Normal University , Guilin 541004 , China.
authors.forename: Heng-Shan
authors.initials: HS
authors.lastname: Wang
authors.affiliation: a State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences , Guangxi Normal University , Guilin 541004 , China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001392:Azocines; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D007529:Isoflavones; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D011807:Quinolizines; D027343:Rhizome / Q000737:chemistry; D029909:Sophora; D000093843:Quinolizidine Alkaloids
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001392:Azocines; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007529:Isoflavones; D011807:Quinolizines; C000613442:(3S,4R)-4-hydroxy-7,4'-dimethoxyisoflavan 3'-O-beta-D-glucopyranoside; C000613441:N-hexanoylcytisine; C004712:cytisine; D000093843:Quinolizidine Alkaloids
keywords: Leguminosae; Sophora tonkinensis; cytisine-type alkaloid; cytotoxic activity; isoflavan