title: Maternal serum interleukin 6 levels and fetomaternal outcomes in women with preterm premature rupture of membranes in Lagos, South-western Nigeria.
abstract: OBJECTIVE
  This study was done to assess the relationship between maternal serum IL-6 levels and fetomaternal outcome following PPROM.
  
  
  METHODS
  This was a prospective cohort study comprising 45 cases of PPROM and 45 controls of similar age, parity, and gestational age. Five milliliters of maternal serum was collected after obtaining informed consent. They were followed up till delivery and records of the delivery and neonatal outcomes were obtained. Serum IL-6 levels were determined by standard enzyme-linked immunosorbent assay [ELISA]. PPROM patients were categorized into two groups using a threshold of 14 pg/ml. Chi-square (χ2) test was used to compare categorical outcomes. p values of < 0.05 were taken as significant.
  
  
  RESULTS
  The mean serum IL-6 level for the women with PPROM was (20.2 ± 11.0 pg/ml), which was significantly greater than for the control subjects (13.9 ± 5.8 pg/ml, p < 0.001). Fetomaternal outcomes were all worse in those with IL-6 ≥ 14 pg/ml. Nevertheless, only the difference in early neonatal deaths was statistically significant.
  
  
  CONCLUSIONS
  Measurement of maternal serum IL-6 can help to indicate hostile intrauterine environments to the fetus as well as identify patients who may benefit from pregnancy prolongation or intervention.
authors.affiliation: a Department of Obstetrics and Gyneacology , Lagos University Teaching Hospital , Lagos , Nigeria and.
authors.forename: Gbemisola Eniola
authors.initials: GE
authors.lastname: Osanyin
authors.affiliation: b Department of Obstetrics and Gyneacology , College of Medicine, University of Lagos/Lagos University Teaching Hospital , Lagos , Nigeria.
authors.forename: Omololu
authors.initials: O
authors.lastname: Adegbola
mesh_terms: D000328:Adult; D000653:Amniotic Fluid; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood*; D009549:Nigeria; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D015850:Interleukin-6
keywords: Fetomaternal outcomes; preterm premature rupture of membranes; serum interleukin 6