title: Nationwide statistical analysis of myeloid malignancies in Korea: incidence and survival rate from 1999 to 2012.
abstract: BACKGROUND
  Large-scale epidemiologic analysis for hematologic malignancies will be helpful to understand the trends in incidence and survival.
  
  
  METHODS
  The Korea Central Cancer Registry (KCCR) updated the nationwide analysis on the incidence and survival of myeloid malignancies, from the Korean National Cancer Incidence Database between 1999 and 2012. Myeloid malignancies were classified based on the International Classification of Diseases for Oncology 3(rd) edition (ICD-O-3).
  
  
  RESULTS
  Overall 3,771 cases of myeloid diseases, which was 1.7% of all cancers, were identified in 2012. The highest incidence of myeloid malignancies was observed in age 70s and male predominance was noted (1.3:1). Acute myeloid leukemia (AML) was the most frequent subtype, followed by myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS) and MDS/MPN: age-standardized incidence rates (ASR) in 2012 for each disease were 2.02, 1.95, 1.13, and 0.12 per 100,000 persons, respectively. The ASR for all myeloid malignancies was increased from 3.31 in 1999 to 5.70 in 2012 with the annual percentage change (APC) of 5.4 %. Five-year relative survival rate (RS) for myeloid malignancies has gradually improved for decades. RS changed from 26.3% to 34.8% in AML, specifically from 51.6% to 69.6% in acute promyelocytic leukemia (APL) and from 23.8% to 29.9% in non-APL AML, between 1996-2000 and 2008-2012. RS also increased from 81.8% to 87.1% in MPN, with a significant improvement in CML (from 74.5% to 85.5%), and from 27.3% to 31.7% in MDS/MPN between 2001-2005 and 2008-2012. However, there was no survival improvement in MDS during the study period (45.6% in 2001-2005 to 44.4% in 2008-2012).
  
  
  CONCLUSIONS
  This report updated the nationwide statistical analysis on myeloid malignancies since 2008, showing increasing incidence and improving trends in survival.
authors.affiliation: The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea.
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Park
authors.affiliation: Hematologic Oncology Clinic, National Cancer Center, Goyang, Korea.
authors.forename: Hyewon
authors.initials: H
authors.lastname: Lee
authors.affiliation: The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea.; Department of Cancer Control and Policy, National Cancer Center, Goyang, Korea.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Won
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, Korea.
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Ju
authors.affiliation: The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea.
authors.forename: Chang-Mo
authors.initials: CM
authors.lastname: Oh
authors.affiliation: The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea.; Department of Cancer Control and Policy, National Cancer Center, Goyang, Korea.
authors.forename: Cecile
authors.initials: C
authors.lastname: Ingabire
authors.affiliation: The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea.
authors.forename: Hyun-Joo
authors.initials: HJ
authors.lastname: Kong
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, Korea.
authors.forename: Byung-Kiu
authors.initials: BK
authors.lastname: Park
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Yoon
authors.affiliation: Hematologic Oncology Clinic, National Cancer Center, Goyang, Korea.; Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
authors.forename: Hyeon-Seok
authors.initials: HS
authors.lastname: Eom
authors.affiliation: Hematologic Oncology Clinic, National Cancer Center, Goyang, Korea.
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Lee
authors.affiliation: Center for Pediatric Oncology, National Cancer Center, Goyang, Korea.
authors.forename: Hyeon Jin
authors.initials: HJ
authors.lastname: Park
keywords: Incidence; Korea; Myeloid malignancy; Survival