title: Current Role of Ivabradine in Stable Coronary Artery Disease Without Heart Failure.
abstract: Increase in heart rate represents a significant contribution in the pathophysiology of coronary artery disease and heart failure, by promoting atherosclerotic process and endothelial dysfunction. Thus, it negatively influences cardiovascular risk in the general population. The aim of this review is to analyze the current, controversial, and future role of ivabradine as an anti-anginal agent in the setting of coronary artery disease without heart failure. Ivabradine represents a selective heart rate-lowering agent that increased diastolic perfusion time and improving energetics in the ischemic myocardium.
authors.affiliation: Department of Internal Medicine, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, 4800 Alberta Ave, El Paso, TX, 79905, USA. mateo.porres@ttuhsc.edu.
authors.forename: Mateo
authors.initials: M
authors.lastname: Porres-Aguilar
authors.affiliation: Division of Cardiovascular Diseases, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, TX, USA.
authors.forename: Oscar C
authors.initials: OC
authors.lastname: Muñoz
authors.affiliation: Division of Cardiovascular Diseases, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, TX, USA.
authors.forename: Aamer
authors.initials: A
authors.lastname: Abbas
mesh_terms: D060050:Angina, Stable / Q000188:drug therapy* / Q000503:physiopathology; D001552:Benzazepines / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D000077550:Ivabradine; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D001552:Benzazepines; D002317:Cardiovascular Agents; D000077550:Ivabradine
keywords: Coronary artery disease; Heart failure; Heart rate; Ivabradine