title: Dextran Nanoparticle Synthesis and Properties.
abstract: Dextran is widely exploited in medical products and as a component of drug-delivering nanoparticles (NPs). Here, we tested whether dextran can serve as the main substrate of NPs and form a stable backbone. We tested dextrans with several molecular masses under several synthesis conditions to optimize NP stability. The analysis of the obtained nanoparticles showed that dextran NPs that were synthesized from 70 kDa dextran with a 5% degree of oxidation of the polysaccharide chain and 50% substitution with dodecylamine formed a NP backbone composed of modified dextran subunits, the mean diameter of which in an aqueous environment was around 100 nm. Dextran NPs could be stored in a dry state and reassembled in water. Moreover, we found that different chemical moieties (e.g., drugs such as doxorubicin) can be attached to the dextran NPs via a pH-dependent bond that allows release of the drug with lowering pH. We conclude that dextran NPs are a promising nano drug carrier.
authors.affiliation: Warsaw University of Technology, Faculty of Chemical Engineering, Warynskiego 1, 00-645 Warsaw, Poland.|NanoVelos Sp. z o.o., Warynskiego 1 / 212, 00-645 Warsaw, Poland.
authors.forename: Iga
authors.initials: I
authors.lastname: Wasiak
authors.affiliation: Warsaw University of Technology, Faculty of Chemical Engineering, Warynskiego 1, 00-645 Warsaw, Poland.|NanoVelos Sp. z o.o., Warynskiego 1 / 212, 00-645 Warsaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kulikowska
authors.affiliation: Warsaw University of Technology, Faculty of Chemical Engineering, Warynskiego 1, 00-645 Warsaw, Poland.|NanoVelos Sp. z o.o., Warynskiego 1 / 212, 00-645 Warsaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Janczewska
authors.affiliation: Warsaw University of Technology, Faculty of Chemical Engineering, Warynskiego 1, 00-645 Warsaw, Poland.|NanoVelos Sp. z o.o., Warynskiego 1 / 212, 00-645 Warsaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Michalak
authors.affiliation: NanoVelos Sp. z o.o., Warynskiego 1 / 212, 00-645 Warsaw, Poland.|International Institute of Molecular and Cell Biology, Trojdena 4, 02-109 Warsaw, Poland.
authors.forename: Iwona A
authors.initials: IA
authors.lastname: Cymerman
authors.affiliation: NanoVelos Sp. z o.o., Warynskiego 1 / 212, 00-645 Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Nagalski
authors.affiliation: Faculty of Physics, University of Vienna, Boltzmanngasse 5, A-1090 Vienna, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Kallinger
authors.affiliation: Faculty of Physics, University of Vienna, Boltzmanngasse 5, A-1090 Vienna, Austria.
authors.forename: Wladyslaw W
authors.initials: WW
authors.lastname: Szymanski
authors.affiliation: Warsaw University of Technology, Faculty of Chemical Engineering, Warynskiego 1, 00-645 Warsaw, Poland.|NanoVelos Sp. z o.o., Warynskiego 1 / 212, 00-645 Warsaw, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Ciach
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D003911:Dextrans / Q000138:chemical synthesis* / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D005612:Freeze Drying; D006367:HeLa Cells; D006801:Humans; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010316:Particle Size
chemical_list: D003911:Dextrans; D004317:Doxorubicin