title: Magnetic resonance spectroscopic imaging at superresolution: Overview and perspectives.
abstract: The notion of non-invasive, high-resolution spatial mapping of metabolite concentrations has long enticed the medical community. While magnetic resonance spectroscopic imaging (MRSI) is capable of achieving the requisite spatio-spectral localization, it has traditionally been encumbered by significant resolution constraints that have thus far undermined its clinical utility. To surpass these obstacles, research efforts have primarily focused on hardware enhancements or the development of accelerated acquisition strategies to improve the experimental sensitivity per unit time. Concomitantly, a number of innovative reconstruction techniques have emerged as alternatives to the standard inverse discrete Fourier transform (DFT). While perhaps lesser known, these latter methods strive to effect commensurate resolution gains by exploiting known properties of the underlying MRSI signal in concert with advanced image and signal processing techniques. This review article aims to aggregate and provide an overview of the past few decades of so-called "superresolution" MRSI reconstruction methodologies, and to introduce readers to current state-of-the-art approaches. A number of perspectives are then offered as to the future of high-resolution MRSI, with a particular focus on translation into clinical settings.
authors.affiliation: Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Switzerland; Department of Radiology and Medical Informatics, University of Geneva, Switzerland.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kasten
authors.affiliation: Department of Radiology and Medical Informatics, University of Geneva, Switzerland.
authors.forename: Antoine
authors.initials: A
authors.lastname: Klauser
authors.affiliation: Department of Radiology and Medical Informatics, University of Geneva, Switzerland.
authors.forename: François
authors.initials: F
authors.lastname: Lazeyras
authors.affiliation: Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Switzerland; Department of Radiology and Medical Informatics, University of Geneva, Switzerland.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Van De Ville
mesh_terms: D000465:Algorithms; D000818:Animals; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*
keywords: Chemical shift imaging; Denoising; Magnetic resonance spectroscopic imaging; Metabolite mapping; Non-Fourier reconstruction; Parametric modeling; Regularization; Spatio-spectral deconvolution; Superresolution