title: Early-Onset Severe Diffuse Alveolar Hemorrhage after Bortezomib Administration Suggestive of Pulmonary Involvement of Myeloma Cells.
abstract: Severe acute lung injury is a rare but life-threatening complication associated with bortezomib. We report a patient with multiple myeloma who developed a severe diffuse alveolar hemorrhage (DAH) immediately after the first bortezomib administration. The patient was suspected to have pulmonary involvement of myeloma, which caused DAH after rapidly eradicating myeloma cells in the lungs with bortezomib. Rechallenge with bortezomib was performed without recurrent DAH. In patients with multiple myeloma who manifest abnormal pulmonary shadow, we should be aware of early-onset severe DAH after bortezomib administration, which might be due to pulmonary involvement of myeloma cells.
authors.affiliation: Department of Hematology, Asahi General Hospital.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Sugita
authors.forename: Chikako
authors.initials: C
authors.lastname: Ohwada
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Nagao
authors.forename: Chika
authors.initials: C
authors.lastname: Kawajiri
authors.forename: Ryoh
authors.initials: R
authors.lastname: Shimizu
authors.forename: Emi
authors.initials: E
authors.lastname: Togasaki
authors.forename: Atsuko
authors.initials: A
authors.lastname: Yamazaki
authors.forename: Tomoya
authors.initials: T
authors.lastname: Muto
authors.forename: Shio
authors.initials: S
authors.lastname: Sakai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takeda
authors.forename: Naoya
authors.initials: N
authors.lastname: Mimura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Emiko
authors.initials: E
authors.lastname: Sakaida
authors.forename: Tohru
authors.initials: T
authors.lastname: Iseki
authors.forename: Koutaro
authors.initials: K
authors.lastname: Yokote
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakaseko
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018450:Disease Progression; D017809:Fatal Outcome; D006470:Hemorrhage / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000556:secondary*; D009101:Multiple Myeloma / Q000188:drug therapy / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000473:pathology*; D013902:Radiography, Thoracic; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed