title: Tug of War in Spindle Orientation.
abstract: The evolutionarily conserved Gαi-LGN-NuMA protein complex is a key regulator of spindle orientation, but how its spatiotemporal localization is achieved remains elusive. Chiu et al. (2016) show that SAPCD2 negatively regulates LGN cortical localization by competing with NuMA for LGN binding in both epithelial cells and mouse retinal progenitor cells.
authors.affiliation: Neuroscience & Behavioral Disorders Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.affiliation: Neuroscience & Behavioral Disorders Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore. Electronic address: hongyan.wang@duke-nus.edu.sg.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D034961:Antigens, Nuclear / Q000378:metabolism*; D016764:Cell Polarity / Q000502:physiology*; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D034521:Nuclear Matrix-Associated Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
chemical_list: D034961:Antigens, Nuclear; D034521:Nuclear Matrix-Associated Proteins; D009687:Nuclear Proteins