title: Composition, in vitro Cytotoxicity, and Anti-mildew Activities of the Leaf Essential Oil of Machilus thunbergii from Taiwan.
abstract: This study investigated the chemical composition, in-vitro cytotoxicity, and anti-mildew fungal activities of the essential oil isolated from the leaf of Machilus thunbergii from Taiwan. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Eighty-three compounds were identified, representing 99.8% of the oil. The main components identified were n-decanal (26.6%), β-caryophyllene (15.8%), α-humulene (10.8%), and β-eudesmol (10.5%). The oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells. The active source compounds were β-caryophyllene, a-humulene, and β-eudesmol. The anti-mildew activity of the leaf oil was also evaluated. Results showed that the leaf oil had excellent anti-mildew activity. For the anti-mildew activity of the leaf oil, the active source compound was determined to be β-eudesmol.
authors.forename: Yu-Chang
authors.initials: YC
authors.lastname: Su
authors.forename: Kuan-Ping
authors.initials: KP
authors.lastname: Hsu
authors.forename: Shu-Ching
authors.initials: SC
authors.lastname: Li
authors.forename: Chen-Lung
authors.initials: CL
authors.lastname: Ho
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D005658:Fungi / Q000187:drug effects; D006801:Humans; D019770:Lauraceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013624:Taiwan
chemical_list: D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile; D010936:Plant Extracts