title: Effects of dynamic synapses on noise-delayed response latency of a single neuron.
abstract: The noise-delayed decay (NDD) phenomenon emerges when the first-spike latency of a periodically forced stochastic neuron exhibits a maximum for a particular range of noise intensity. Here, we investigate the latency response dynamics of a single Hodgkin-Huxley neuron that is subject to both a suprathreshold periodic stimulus and a background activity arriving through dynamic synapses. We study the first-spike latency response as a function of the presynaptic firing rate f. This constitutes a more realistic scenario than previous works, since f provides a suitable biophysically realistic parameter to control the level of activity in actual neural systems. We first report on the emergence of classical NDD behavior as a function of f for the limit of static synapses. Second, we show that when short-term depression and facilitation mechanisms are included at the synapses, different NDD features can be found due to their modulatory effect on synaptic current fluctuations. For example, an intriguing double NDD (DNDD) behavior occurs for different sets of relevant synaptic parameters. Moreover, depending on the balance between synaptic depression and synaptic facilitation, single NDD or DNDD can prevail, in such a way that synaptic facilitation favors the emergence of DNDD whereas synaptic depression favors the existence of single NDD. Here we report the existence of the DNDD effect in the response latency dynamics of a neuron.
authors.affiliation: Department of Biomedical Engineering, Bulent Ecevit University, Engineering Faculty, 67100 Zonguldak, Turkey.|The Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia 22030, USA.
authors.forename: M
authors.initials: M
authors.lastname: Uzuntarla
authors.affiliation: Department of Electrical and Electronics Engineering, Bulent Ecevit University, Engineering Faculty, 67100 Zonguldak, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ozer
authors.affiliation: Department of Biomedical Engineering, Bulent Ecevit University, Engineering Faculty, 67100 Zonguldak, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Ileri
authors.affiliation: Department of Biomedical Engineering, Bulent Ecevit University, Engineering Faculty, 67100 Zonguldak, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Calim
authors.affiliation: Department of Electromagnetism and Physics of the Matter and Institute "Carlos I" for Theoretical and Computational Physics, University of Granada, Granada E-18071, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Torres