title: Neutralization breadth and potency of serum derived from recently human immunodeficiency virus type 1-infected Thai individuals.
abstract: Neutralizing antibody responses play important roles in controlling several viral infections including human immunodeficiency virus type 1 (HIV-1). Potent and broad neutralizing antibody responses have been reported in some HIV-1-infected individuals; therefore, elucidating the mechanisms underlying neutralizing antibody responses will provide important information for the development of anti-HIV-1 vaccines. We herein performed a comparative study on the neutralization breadth and potency of serum samples collected from Thai individuals recently and chronically infected with HIV-1. Neutralization tests using a series of envelope glycoproteins (Env)-recombinant viruses revealed that although several serum samples derived from recently infected individuals did not show any HIV-1-specific neutralizing activity, the remaining serum samples exhibited neutralizing activity not only for recombinant viruses with CRF01_AE Env, but also for viruses with subtypes B and C Env. Furthermore, some serum samples derived from recently infected individuals showed the neutralization potency. Our results may provide a deeper insight into the characteristics of neutralizing antibody responses that develop during the course of HIV-1 infection among individuals in Thailand.
authors.affiliation: Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand.
authors.forename: Nithinart
authors.initials: N
authors.lastname: Chaitaveep
authors.affiliation: Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI), Nonthaburi, Thailand.
authors.forename: Piraporn
authors.initials: P
authors.lastname: Utachee
authors.affiliation: Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand.
authors.forename: Thippawan
authors.initials: T
authors.lastname: Chuenchitra
authors.affiliation: Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand.
authors.forename: Nicos
authors.initials: N
authors.lastname: Karasavvan
authors.affiliation: Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI), Nonthaburi, Thailand; Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
authors.forename: Naokazu
authors.initials: N
authors.lastname: Takeda
authors.affiliation: Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; Department of International Health, Kobe University Graduate School of Health Sciences, Hyogo, Japan. Electronic address: mkameoka@port.kobe-u.ac.jp.
authors.forename: Masanori
authors.initials: M
authors.lastname: Kameoka
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood*; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D009500:Neutralization Tests; D044967:Serum / Q000276:immunology; D013785:Thailand; D055815:Young Adult; D054299:env Gene Products, Human Immunodeficiency Virus / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D054299:env Gene Products, Human Immunodeficiency Virus
keywords: CRF01_AE; Neutralization; Recent HIV-1 infection; Thailand