title: Palladium-catalyzed direct C-H arylation of 3-aryl-2H-benzo[1,2,4]thiadiazine 1,1-dioxides: an efficient strategy to the synthesis of benzothiadiazine-1,1-dioxide derivatives.
abstract: A new palladium-catalyzed benzothiadiazine-1,1-dioxide direct arylation of C(sp(2))-H bonds is described. 3-Aryl-2H-benzo[1,2,4]thiadiazine 1,1-dioxides react with various aryl iodides to give the corresponding mono-arylation products 3-(biphenyl-2-yl)-2H-benzo[1,2,4]thiadiazine 1,1-dioxides with high reactivity and regioselectivity in the presence of AgOAc. Remarkedly, the addition of TFA is crucial to improve the arylation yield.
authors.affiliation: Department of Chemistry, Jiangxi Normal University, Nanchang, 330022, PR China and Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Nanchang, 330022, PR China.
authors.forename: Dongyin
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Jiangxi Normal University, Nanchang, 330022, PR China and Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Nanchang, 330022, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Jiangxi Normal University, Nanchang, 330022, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yi
authors.affiliation: Department of Chemistry, Jiangxi Normal University, Nanchang, 330022, PR China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, Jiangxi Normal University, Nanchang, 330022, PR China and Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Nanchang, 330022, PR China.
authors.forename: Junmin
authors.initials: J
authors.lastname: Chen