title: [Identification of Target Extracellular Proteases--Activators of Proteins of Haemostasis System Produced by Micromycetes Aspergillus ochraceus and Aspergillus terreus].
abstract: Effects of extracellular proteases of Aspergillus ochraceus and Aspergillus terreus on plasma hemostasis proteins, consist of initiating the activation of prothrombin complex proteins, was detected. Was discovered, that A. ochraceus proteases have a direct influence on protein C and coagulation factor X, and A. terreus proteases causes their activation indirectly through kallikrein system stimulation. The ability of extracellular proteases of micromycetes activate prekallikrein in human blood plasma on the example of A. terreus was first demonstrated.
authors.forename: E S
authors.initials: ES
authors.lastname: Zvonareva
authors.forename: A A
authors.initials: AA
authors.lastname: Osmolovskiy
authors.forename: V G
authors.initials: VG
authors.lastname: Kreyer
authors.forename: N A
authors.initials: NA
authors.lastname: Baranova
authors.forename: I B
authors.initials: IB
authors.lastname: Kotova
authors.forename: N S
authors.initials: NS
authors.lastname: Egorov
mesh_terms: D001235:Aspergillus ochraceus / Q000201:enzymology*; D001798:Blood Proteins / Q000032:analysis* / Q000737:chemistry; D005170:Factor X / Q000032:analysis / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D010447:Peptide Hydrolases / Q000737:chemistry* / Q000378:metabolism; D010949:Plasma / Q000737:chemistry; D011288:Prekallikrein / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D011486:Protein C / Q000032:analysis / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D001798:Blood Proteins; D011486:Protein C; D005170:Factor X; D011288:Prekallikrein; D010447:Peptide Hydrolases