title: Human Stem Cells Can Differentiate in Post-implantation Mouse Embryos.
abstract: The potency of human pluripotent stem cells (hPSCs) to differentiate into germ layer derivatives is conventionally assessed by teratoma induction and in vitro differentiation. In this issue of Cell Stem Cell, Mascetti and Pedersen (2016) demonstrate that the human-mouse post-implantation chimera offers an efficient avenue to test the germ layer differentiation potential of hPSCs in mouse embryos ex vivo.
authors.affiliation: Embryology Unit, Children's Medical Research Institute, Sydney Medical School, University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia. Electronic address: ptam@cmri.org.au.
authors.forename: Patrick P L
authors.initials: PP
authors.lastname: Tam
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D010064:Embryo Implantation; D005855:Germ Layers / Q000166:cytology*; D006801:Humans; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology*; D013724:Teratoma