title: Investigation of associations between ten polymorphisms and the risk of coronary artery disease in Southern Han Chinese.
abstract: A large-scale meta-analysis of 14 genome-wide association studies has identified and replicated a series of susceptibility polymorphisms for coronary artery disease (CAD) in European ancestry populations, but evidences for the associations of these loci with CAD in other ethnicities remain lacking. Herein we investigated the associations between ten (rs579459, rs12413409, rs964184, rs4773144, rs2895811, rs3825807, rs216172, rs12936587, rs46522 and rs3798220) of these loci and CAD in Southern Han Chinese (CHS). Genotyping was performed in 1716 CAD patients and 1572 controls using mass spectrography. Both allelic and genotypic associations of rs964184, rs2895811 and rs3798220 with CAD were significant, regardless of adjustment for covariates of gender, age, hypertension, type 2 diabetes, blood lipid profiles and smoking. Significant association of rs12413409 was initially not observed, but after the adjustment for the covariates, both allelic and genotypic associations were identified as significant. Neither allelic nor genotypic association of the other six polymorphisms with CAD was significant regardless of the adjustment. Our results indicated that four loci of the total 10 were associated with CAD in CHS. Therefore, some of the CAD-related loci in European ancestry populations are indeed susceptibility loci for the risk of CAD in Han Chinese.
authors.affiliation: Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.|Guangzhou Forensic Science Institute, Guangzhou, Guangdong, China.
authors.forename: Er-Wen
authors.initials: EW
authors.lastname: Huang
authors.affiliation: Department of Cardiology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Long-Yun
authors.initials: LY
authors.lastname: Peng
authors.affiliation: Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Jin-Xiang
authors.initials: JX
authors.lastname: Zheng
authors.affiliation: Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Intensive Care Unit, Guangzhou Brain Hospital, Guangzhou, Guangdong, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Tan
authors.affiliation: Department of Cardiology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Zhong-Yi
authors.initials: ZY
authors.lastname: Yang
authors.affiliation: Department of Cardiology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Qiu-Ping
authors.initials: QP
authors.lastname: Wu
authors.affiliation: Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Shuang-Bo
authors.initials: SB
authors.lastname: Tang
authors.affiliation: Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Luo
authors.affiliation: Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Li
authors.initials: L
authors.lastname: Quan
authors.affiliation: Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Shui-Ping
authors.initials: SP
authors.lastname: Liu
authors.affiliation: Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Xiao-Shan
authors.initials: XS
authors.lastname: Liu
authors.affiliation: Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Li
authors.affiliation: Guangzhou Forensic Science Institute, Guangzhou, Guangdong, China.
authors.forename: He
authors.initials: H
authors.lastname: Shi
authors.affiliation: Guangzhou Forensic Science Institute, Guangzhou, Guangdong, China.
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Lv
authors.affiliation: Guangzhou Forensic Science Institute, Guangzhou, Guangdong, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Guangzhou Forensic Science Institute, Guangzhou, Guangdong, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Jian-Ding
authors.initials: JD
authors.lastname: Cheng
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk