title: Relationships of related genetic polymorphisms and individualized medication of tacrolimus in patients with renal transplantation.
abstract: The aim of this study was to establish clinical and genetic factors-based individual administration model of tacrolimus for Chinese Han patients after renal transplantation (RT). The genetic polymorphisms of CYP3A4, CYP3A5 and MDR1 in 216 RT patients were detected by PCR-RFLP, the genetic and clinical factors and blood concentration/dose × body weight (C/D) values of tacrolimus were performed the single factor correlation analysis, and established the dose prediction algorithm of tacrolimus by stepwise multiple regression analysis. CYP3A5*3, hematocrit and albumin were correlated with the C/D values of tacrolimus, the best regression model could explain 28.3% reason of individual dose differences of tacrolimus, among which CYP3A5*3 polymorphism could explain 23.5%. The genetic factors played an important role in the dose differences of tacrolimus, the patients should be checked CYP3A5*3 genotype before administration of tacrolimus to predict the tacrolimus doses, thus helping to improve the safety and effectiveness of tacrolimus application.
authors.affiliation: Department of Pharmacy, Fuzhou General Hospital of Nanjing Command PLAFuzhou 350025, China; Department of Pharmacy, Yantai Affiliated Hospital of Binzhou Medical UniversityYantai 264100, Shandong, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Pharmacy, Fuzhou General Hospital of Nanjing Command PLA Fuzhou 350025, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, Fuzhou General Hospital of Nanjing Command PLA Fuzhou 350025, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Urology, Fuzhou General Hospital of Nanjing Military Region Fuzhou 350025, Fujian, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Urology, Fuzhou General Hospital of Nanjing Military Region Fuzhou 350025, Fujian, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Tan
authors.affiliation: Department of Urology, Fuzhou General Hospital of Nanjing Military Region Fuzhou 350025, Fujian, China.
authors.forename: Weizhen
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Pharmacy, Fuzhou General Hospital of Nanjing Command PLA Fuzhou 350025, China.
authors.forename: Meiqin
authors.initials: M
authors.lastname: Lin
keywords: CYP3A4; CYP3A5; MDR1; Tacrolimus; genetic polymorphism; individualized medication; renal transplantation