title: Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205.
abstract: Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice. Sodium valproate was used as the reference substance. RU-1205 was superior to sodium valproate by anticonvulsant activity (by 12 times) and therapeutic index (by 8.5 times). In contrast to sodium valproate, RU-1205 exhibited significant anticonvulsant activity on the model of pentylenetetrazole-induced kindling without tendency to resistance development.
authors.affiliation: Volgograd State Medical University, Volgograd, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.affiliation: Volgograd State Medical University, Volgograd, Russia. kkonst8@yandex.ru.
authors.forename: K Yu
authors.initials: KY
authors.lastname: Kalitin
authors.affiliation: Volgograd State Medical University, Volgograd, Russia.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Grechko
authors.affiliation: Volgograd State Medical University, Volgograd, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000737:chemistry / Q000627:therapeutic use*; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D051379:Mice; D009025:Morpholines / Q000737:chemistry / Q000627:therapeutic use*; D010433:Pentylenetetrazole / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: C586860:9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo(1,2-alpha)benzimidazole; D000927:Anticonvulsants; D001562:Benzimidazoles; D009025:Morpholines; D014635:Valproic Acid; D010433:Pentylenetetrazole
keywords: anticonvulsant effect; antiepileptic activity; epilepsy; kindling; pentylenetetrazole