title: Carcinogenicity and chronic toxicity of hydrazine monohydrate in rats and mice by two-year drinking water treatment.
abstract: The carcinogenicity and chronic toxicity of hydrazine monohydrate was examined by administrating hydrazine monohydrate in drinking water to groups of 50 F344/DuCrj rats and 50 Crj:BDF1 mice of both sexes for two years. The drinking water concentration of hydrazine monohydrate was 0, 20, 40 or 80 ppm (wt/wt) for male and female rats and male mice; and 0, 40, 80 or 160 ppm for female mice. Survival rates of each group of males and females rats and mice were similar to the respective controls, except female rats administered 80 ppm. Two-year administration of hydrazine monohydrate produced an increase in the incidences of hepatocellular adenomas and carcinomas in rats of both sexes along with hepatic foci. In mice, the incidences of hepatocellular adenomas and carcinomas were increased in females, and significantly increased incidences of hepatocellular adenomas in females administered 160 ppm were observed. Thus, hydrazine monohydrate is carcinogenic in two species, rats and mice. Additionally, non-neoplastic renal lesions in rats and mice and non-neoplastic nasal lesions in mice were observed.
authors.affiliation: Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445 Hirasawa, Hadano, Kanagawa, 257-0015, Japan. Electronic address: m-matsumoto@jisha.or.jp.
authors.forename: Michiharu
authors.initials: M
authors.lastname: Matsumoto
authors.affiliation: Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445 Hirasawa, Hadano, Kanagawa, 257-0015, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kano
authors.affiliation: Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445 Hirasawa, Hadano, Kanagawa, 257-0015, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445 Hirasawa, Hadano, Kanagawa, 257-0015, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Katagiri
authors.affiliation: Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445 Hirasawa, Hadano, Kanagawa, 257-0015, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Umeda
authors.affiliation: Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445 Hirasawa, Hadano, Kanagawa, 257-0015, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Fukushima
mesh_terms: D000236:Adenoma / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D000284:Administration, Oral; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D002277:Carcinoma / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D004326:Drinking / Q000187:drug effects; D060766:Drinking Water; D004435:Eating / Q000187:drug effects; D005260:Female; D006834:Hydrazines / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008113:Liver Neoplasms / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D009666:Nose / Q000187:drug effects / Q000473:pathology; D011916:Rats, Inbred F344; D018570:Risk Assessment; D012737:Sex Factors; D013045:Species Specificity; D013997:Time Factors; D036401:Toxicity Tests, Chronic
chemical_list: D015415:Biomarkers; D002273:Carcinogens; D060766:Drinking Water; D006834:Hydrazines; C029424:hydrazine
keywords: Carcinogenicity; Chronic toxicity; Hydrazine monohydrate; Liver; Mice; Rats