title: Herbal Medicines Prevent the Development of Atopic Dermatitis by Multiple Mechanisms.
abstract: Atopic dermatitis (AD) is among the most common skin disorders in humans. Although a variety of regimens are available for the treatment of AD, preventive approaches are limited. Recent studies have demonstrated that certain naturally-occurring herbal medicines are effective in preventing the development of AD via divergent mechanisms, such as inhibiting cytokine and chemokine expression, IgE production, inflammatory cell infiltration, histamine release, and/or enhancement of epidermal permeability barrier function. Yet, they exhibit few adverse effects. Since herbal medicines are widely available, inexpensive and generally safe, they could represent an ideal approach for preventing the development of AD, in both highly developed and developing countries.
authors.affiliation: Dermatology Service, Veterans Affairs Medical Center, CA, 94121, USA.|Department of Dermatology, University of California, San Francisco, CA, 94121, USA.
authors.forename: Mao-Qiang
authors.initials: MQ
authors.lastname: Man
authors.affiliation: School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Li-Zhi
authors.initials: LZ
authors.lastname: Hu
authors.affiliation: Dermatology Service, Veterans Affairs Medical Center, CA, 94121, USA.|Department of Dermatology, University of California, San Francisco, CA, 94121, USA.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Elias
mesh_terms: D000818:Animals; D018925:Chemokines / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000517:prevention & control*; D004195:Disease Models, Animal; D029001:Herbal Medicine; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D007249:Inflammation / Q000473:pathology
chemical_list: D018925:Chemokines; D007073:Immunoglobulin E
keywords: T cells; cytokines; dermatitis; herbal medicines; permeability barrier