title: Generation of Oxazolidine-2,4-diones Bearing Sulfur-Substituted Quaternary Carbon Atoms by Oxothiolation/Cyclization of Ynamides.
abstract: A novel method for metal-free oxothiolation of ynamides to construct oxazolidine-2,4-diones bearing sulfur-substituted quaternary carbon atoms has been developed. It represents a rare C-O bond cleavage of ynamides, as well as a facile and tandem approach for the formation of C-O, C-S, and C-Cl bonds. This redox-neutral protocol can be applied to the synthesis of multisubstituted oxazolidine-2,4-diones with good chemoselectivity and good yields of isolated products under mild conditions.
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, No. 30 North Puzhu Road, Nanjing, 211816, P. R. China.
authors.forename: Hai
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, No. 30 North Puzhu Road, Nanjing, 211816, P. R. China.
authors.forename: Junzhen
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, No. 30 North Puzhu Road, Nanjing, 211816, P. R. China. hegk@njtech.edu.cn.
authors.forename: Guangke
authors.initials: G
authors.lastname: He
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, No. 30 North Puzhu Road, Nanjing, 211816, P. R. China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, No. 30 North Puzhu Road, Nanjing, 211816, P. R. China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, No. 30 North Puzhu Road, Nanjing, 211816, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, No. 30 North Puzhu Road, Nanjing, 211816, P. R. China. zhuhj@njtech.edu.cn.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Zhu
keywords: cyclization; heterocycles; oxothiolation; synthetic methods; ynamides