title: Palladium-Catalyzed Site-Selective C-H Functionalization of Weakly Coordinating Sulfonamides: Synthesis of Biaryl Sulfonamides.
abstract: A novel and site selective C-H functionalization of unsubstituted sulfonamides has been developed for the synthesis of ortho aryl sulfonamides. The reaction involves highly regioselective ortho mono arylation of weakly coordinating SO2 NH2 directing group by means of aryl iodides. Palladium acetate in the presence of silver(I) oxide is found to be the most effective catalytic system.
authors.affiliation: Department of Chemistry (Centre of Advanced Study), Faculty of Science, Banaras Hindu University, Varanasi-, 221005, India.
authors.forename: Rajeshwer
authors.identifier: http://orcid.org/0000-0002-5816-5305
authors.initials: R
authors.lastname: Vanjari
authors.affiliation: Department of Chemistry (Centre of Advanced Study), Faculty of Science, Banaras Hindu University, Varanasi-, 221005, India.
authors.forename: Tirumaleswararao
authors.identifier: http://orcid.org/0000-0003-0566-0895
authors.initials: T
authors.lastname: Guntreddi
authors.affiliation: Department of Chemistry (Centre of Advanced Study), Faculty of Science, Banaras Hindu University, Varanasi-, 221005, India. knsingh@bhu.ac.in.
authors.forename: Krishna Nand
authors.initials: KN
authors.lastname: Singh
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D010165:Palladium / Q000737:chemistry*; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis* / Q000737:chemistry; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D013449:Sulfonamides; D010165:Palladium
keywords: C−H functionalization; biaryl sulfonamides; site selectivity; sulfonamides; weak coordination