title: [Etiological analysis of 264 cases with chronic kidney disease stage 2 to 5 in children].
abstract: OBJECTIVE
  To study and summarize the etiology of children patients with chronic kidney disease (CKD) stage 2 to 5 seen in Children's Hospital of Fudan University from Jan. 2004 to Dec. 2013.
  
  
  METHODS
  By complying with the NKF-K/DOQI guidelines, we collected data of 264 cases of children patients with CKD stage 2-5 from Jan. 2004 to Dec. 2013 in the medical record system of Children's Hospital of Fudan University. And we retrospectively analyzed their age and CKD stage at first diagnosis, primary diseases, complications, etc.
  
  
  RESULTS
  In the collected 264 cases, 52 cases (19.7%) were diagnosed at stage 2, 67 (25.4%) at stage 3, 52 (19.7%) at stage 4 and 93 (35.2%) at stage 5. For disease causes, 116 cases (43.9%) had congenital anomalies of the kidney and urinary tract (CAKUT), 61 cases (23.1%) had glomerular disease, 15 (5.7%) had hereditary kidney disease, 14 (5.3%) had other diseases and in 58 cases (22.0%) the causes of disease were unknown. In the group with age between 0 and 3.0 and 3.1 and 6.0 years, 57.1% (24 cases) and 60.0% (30 cases) had primary disease with CAKUT. In the group with age older than 10 years, 49.2% (30 cases) had primary disease with glomerular disease and 32.0% (32 cases) with unknown causes.
  
  
  CONCLUSIONS
  The major cause of CKD stage 2-5 in children in our hospital during the last ten years was CAKUT (43.9%), followed by glomerular disease (23.1%). The primary diseases of CKD were significantly different between the 2 age groups. CAKUT was more common in infants and preschool children while for adolescents, glomerular disease was the major cause.
authors.affiliation: Department of Nephrology and Rheumatology, Children's Hospital of Fudan University, Shanghai 201102, China.
authors.forename: Qianfan
authors.initials: Q
authors.lastname: Miao
authors.forename: Qian
authors.initials: Q
authors.lastname: Shen
authors.affiliation: Email: hxu@shmu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Xiaoshan
authors.initials: X
authors.lastname: Tang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Fang
authors.forename: Haimei
authors.initials: H
authors.lastname: Liu
authors.forename: Yihui
authors.initials: Y
authors.lastname: Zhai
authors.forename: Yunli
authors.initials: Y
authors.lastname: Bi
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D002648:Child; D002675:Child, Preschool; D002681:China; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000503:physiopathology; D051436:Renal Insufficiency, Chronic / Q000209:etiology*; D012189:Retrospective Studies