title: Observation of an improved healing process in superficial skin wounds after irradiation with a blue-LED haemostatic device.
abstract: The healing process of superficial skin wounds treated with a blue-LED haemostatic device is studied. Four mechanical abrasions are produced on the back of 10 Sprague Dawley rats: two are treated with the blue-LED device, while the other two are left to naturally recover. Visual observations, non-linear microscopic imaging, as well as histology and immunofluorescence analyses are performed 8 days after the treatment, demonstrating no adverse reactions neither thermal damages in both abraded areas and surrounding tissue. A faster healing process and a better-recovered skin morphology are observed: the treated wounds show a reduced inflammatory response and a higher collagen content. Blue LED induced photothermal effect on superficial abrasions.
authors.affiliation: National Institute of Optics, National Research Council (INO-CNR), Florence, 50125, Italy.|European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino, 50019, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Cicchi
authors.affiliation: Institute of Applied Physics, National Research Council (IFAC-CNR), Sesto Fiorentino, 50019, Italy. f.rossi@ifac.cnr.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Rossi
authors.affiliation: Light4tech Firenze S.r.l., Scandicci, 50018, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Alfieri
authors.affiliation: Department of Clinical and Experimental Medicine, University of Florence, Florence, 50139, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Bacci
authors.affiliation: Institute of Applied Physics, National Research Council (IFAC-CNR), Sesto Fiorentino, 50019, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Tatini
authors.affiliation: Institute of Applied Physics, National Research Council (IFAC-CNR), Sesto Fiorentino, 50019, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: De Siena
authors.affiliation: Department of Clinical and Experimental Medicine, University of Florence, Florence, 50139, Italy.
authors.forename: Gaia
authors.initials: G
authors.lastname: Paroli
authors.affiliation: Institute of Applied Physics, National Research Council (IFAC-CNR), Sesto Fiorentino, 50019, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pini
authors.affiliation: National Institute of Optics, National Research Council (INO-CNR), Florence, 50125, Italy.|European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino, 50019, Italy.|Department of Physics, University of Florence, Sesto Fiorentino, 50019, Italy.
authors.forename: Francesco S
authors.initials: FS
authors.lastname: Pavone
mesh_terms: D000818:Animals; D006490:Hemostatics / Q000627:therapeutic use*; D008027:Light; D010789:Phototherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000293:injuries*; D014945:Wound Healing
chemical_list: D006490:Hemostatics
keywords: Thermal effects; blue light-emitting diodes; photocoagulation; wound healing