title: Involvement of Bcl-2-associated athanogene (BAG)-family proteins in the neuroprotection by rasagiline.
abstract: Rasagiline, a novel monoamine oxidase (MAO)-B inhibitor, has a mild to moderate effect in relieving Parkinson's disease (PD) symptoms as well as unique neuroprotective effects. Previous studies demonstrated rasagiline protect neurons by regulating Bcl-2 family proteins. Our study aimed to study whether Bcl-2-associated athanogene (BAG)-family proteins, which were reported closely associated with neurodegenerative disease, were involved in the neuroprotective effect of rasagiline. We found that after the administration of 1-methy1-4-phenvl-1,2,3,6-tetrahvdropvridine (MPTP), BAG2 and BAG5 proteins were up-regulated in the substantia nigra dopaminergic neurons of PD mouse model. A further increase of BAG2 and BAG5 was detected after intragastric administration of rasagiline to post-MPTP lesioned mice. Thus, the current study proved the association of BAG family proteins with PD, and suggested the involvement and a positive role of BAG2, BAG5 in the neuroprotection of rasagiline. These preliminary results implicate a novel pathway for further study on neuroprotection of rasagiline.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South UniversityChangsha 410008, Hunan, People's Republic of China; State Key Laboratory of Medical GeneticsChangsha 410008, Hunan, People's Republic of China; Key Laboratory of Human Province In Neurodegenerative Disorders, Central South UniversityChangsha 410008, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South UniversityChangsha 410008, Hunan, People's Republic of China.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Guo
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University Changsha 410008, Hunan, People's Republic of China.
authors.forename: Shuang
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University Changsha 410008, Hunan, People's Republic of China.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Kang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South UniversityChangsha 410008, Hunan, People's Republic of China; Key Laboratory of Human Province In Neurodegenerative Disorders, Central South UniversityChangsha 410008, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South UniversityChangsha 410008, Hunan, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South UniversityChangsha 410008, Hunan, People's Republic of China; Key Laboratory of Human Province In Neurodegenerative Disorders, Central South UniversityChangsha 410008, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South UniversityChangsha 410008, Hunan, People's Republic of China.
authors.forename: Ya-Cen
authors.initials: YC
authors.lastname: Hu
authors.affiliation: Key Laboratory of Human Province In Neurodegenerative Disorders, Central South UniversityChangsha 410008, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South UniversityChangsha 410008, Hunan, People's Republic of China.
authors.forename: Hai-Nan
authors.initials: HN
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Human Province In Neurodegenerative Disorders, Central South UniversityChangsha 410008, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South UniversityChangsha 410008, Hunan, People's Republic of China.
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South UniversityChangsha 410008, Hunan, People's Republic of China; Key Laboratory of Human Province In Neurodegenerative Disorders, Central South UniversityChangsha 410008, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South UniversityChangsha 410008, Hunan, People's Republic of China.
authors.forename: Xin-Xiang
authors.initials: XX
authors.lastname: Yan
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South UniversityChangsha 410008, Hunan, People's Republic of China; State Key Laboratory of Medical GeneticsChangsha 410008, Hunan, People's Republic of China; Key Laboratory of Human Province In Neurodegenerative Disorders, Central South UniversityChangsha 410008, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South UniversityChangsha 410008, Hunan, People's Republic of China.
authors.forename: Bei-Sha
authors.initials: BS
authors.lastname: Tang
keywords: BAG protein; MPTP; Rasagline; neuroprotection