title: Transcriptional regulation of early T-cell development in the thymus.
abstract: T-cell development occurs in multipotent progenitors arriving in the thymus, which provides a highly specialized microenvironment. Specification and sequential commitment processes to T cells begin in early thymic progenitors upon receiving thymus-specific environmental cues, resulting in the activation of the genetically programmed transcriptional cascade that includes turning on and off numerous transcription factors in a precise manner. Thus, early thymocyte differentiation has been an excellent model system to study cell differentiation processes. This review summarizes recent advances in our knowledge on thymic T-cell development from newly arrived multipotent T-cell progenitors to fully committed T-cell precursors, from the transcriptional regulation perspective.
authors.affiliation: Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
authors.forename: Wooseok
authors.initials: W
authors.lastname: Seo
authors.affiliation: Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Taniuchi
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage; D005786:Gene Expression Regulation; D008213:Lymphocyte Activation; D054504:Precursor Cells, T-Lymphoid / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology* / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: D014157:Transcription Factors
keywords: T-cell development; T-cell progenitors; Thymus; Transcription factors; Transcriptional network; Transcriptional regulation