title: Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study.
abstract: BACKGROUND
  Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions.
  
  
  OBJECTIVE
  The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907).
  
  
  METHODS
  AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years.
  
  
  RESULTS
  Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients.
  
  
  CONCLUSIONS
  In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction.
authors.affiliation: a Department of Internal Medicine , Federal Armed Forces Central Hospital , Koblenz , Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Bickel
authors.affiliation: b Department of General and Interventional Cardiology , University Heart Center Hamburg , Hamburg , Germany.
authors.forename: Renate B
authors.initials: RB
authors.lastname: Schnabel
authors.affiliation: b Department of General and Interventional Cardiology , University Heart Center Hamburg , Hamburg , Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Zeller
authors.affiliation: c Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg-University Mainz , Mainz , Germany.
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Lackner
authors.affiliation: d Department of Medicine II , GPR Rüsselsheim , Rüsselsheim , Germany.
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Rupprecht
authors.affiliation: b Department of General and Interventional Cardiology , University Heart Center Hamburg , Hamburg , Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
authors.affiliation: b Department of General and Interventional Cardiology , University Heart Center Hamburg , Hamburg , Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Sinning
authors.affiliation: b Department of General and Interventional Cardiology , University Heart Center Hamburg , Hamburg , Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Westermann
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000401:mortality*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012737:Sex Factors
chemical_list: D020738:Leptin
keywords: Cardiovascular events; coronary artery disease; leptin; prognosis