title: Ti nanorod arrays with a medium density significantly promote osteogenesis and osteointegration.
abstract: Ti implants are good candidates in bone repair. However, how to promote bone formation on their surface and their consequent perfect integration with the surrounding tissue is still a challenge. To overcome such challenge, we propose to form Ti nanorods on their surface to promote the new bone formation around the implants. Here Ti nanorod arrays (TNrs) with different densities were produced on pure Ti surfaces using an anodizing method. The influence of TNr density on the protein adsorption as well as on the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 pre-osteoblastic cells were assessed. The TNrs were also implanted into the bone defects in rabbits to test their application in promoting bone formation and osteointegration at the implant-bone interface. TNrs with the medium density were found to show the best capability in promoting the protein adsorption from surrounding medium, which in turn efficiently enhanced osteogenic differentiation in vitro and osteointegration in vivo. Our work suggests that growing TNrs with a medium density on the surface of traditional Ti implants is an efficient and facile method for promoting bone formation and osteointegration in bone repair.
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Chengyun
authors.initials: C
authors.lastname: Ning
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Shuangying
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Chemistry &Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019-5300,United States.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Meiling
authors.initials: M
authors.lastname: Zhong
authors.affiliation: General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Lin
authors.affiliation: General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Tan
authors.affiliation: General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: School of Materials Science and Technology, Kunming University of Science and Technology, Kunming 650093, China.
authors.forename: Zhaoyi
authors.initials: Z
authors.lastname: Yin
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yu
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Tianrui
authors.initials: T
authors.lastname: He
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Chemistry &Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019-5300,United States.|School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Mao
mesh_terms: D000327:Adsorption; D000818:Animals; D000069343:Bone-Implant Interface / Q000502:physiology*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D020007:Implants, Experimental / Q000662:veterinary; D008297:Male; D051379:Mice; D043942:Nanotubes / Q000737:chemistry / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia / Q000601:surgery; D014025:Titanium / Q000494:pharmacology*
chemical_list: D014025:Titanium