title: Evaluation of Color-Changing Effect and Complications After Nd: YAG Laser Application On Iris Surface.
abstract: BACKGROUND
  The aim of this study was to evaluate the color-changing effect and adverse effects after Nd: YAG laser application on the iris surface of rabbit eyes.
  
  
  METHODS
  The study was performed on right eyes of 12 pigmented rabbits. A laser device that produces frequency doubled 532 nm wavelength Nd: YAG laser with 900 μm spot diameter was used. The laser was applied in 3 sessions at 2-week intervals, at energy levels of 0.8 mJ in Group A and 1.5 mJ in Group B. Slit-lamp examinations and measurements of intraocular pressure (IOP) using a Tono-Pen were performed before and 1 day after each laser session. Iris thickness (IT) was measured at the beginning and the end using an ultrasonic biomicroscope. The eyes were enucleated for histopathologic examination on day 60.
  
  
  RESULTS
  On the first day after each laser session, maximum grade 1 anterior chamber flare and cells were observed in both groups. In all eyes, flare and cells disappeared at the end of the first week. There was no significant difference in the IOP and IT values between measurements performed prior to and after laser sessions during the study (p>0.05). None of the eyes showed complications such as corneal edema, hypopyon, posterior synechia, transillumination defect, or pupillary defect. In histopathological examinations, reduction in pigment density was more profound in Group B compared to Group A, which was statistically significant (p<0.019).
  
  
  CONCLUSIONS
  There were no serious complications apart from mild transient inflammatory signs. Change in iris color was more evident at the end of the second month.
authors.affiliation: Department of Ophthalmology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: Yildiray
authors.initials: Y
authors.lastname: Yildirim
authors.affiliation: Department of Ophthalmology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: Eyup
authors.initials: E
authors.lastname: Duzgun
authors.affiliation: Department of Ophthalmology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Kar
authors.affiliation: Department of Ophthalmology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Sonmez
authors.affiliation: Department of Pathology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Kucukodaci
authors.affiliation: Department of Ophthalmology, Dünya Göz Hospital, Istanbul, Turkey.
authors.forename: Dilaver
authors.initials: D
authors.lastname: Ersanli
authors.affiliation: Department of Ophthalmology, Ümraniye Eye Center, Istanbul, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Basoglu
mesh_terms: D000818:Animals; D005127:Eye Color / Q000528:radiation effects*; D007429:Intraocular Pressure / Q000528:radiation effects*; D007431:Intraoperative Complications; D007498:Iris / Q000503:physiopathology* / Q000528:radiation effects*; D053685:Laser Therapy; D053844:Lasers, Solid-State; D008853:Microscopy; D009885:Ophthalmology / Q000295:instrumentation; D010858:Pigmentation; D011817:Rabbits; D013997:Time Factors