title: Genetic affinities of the Jewish populations of India.
abstract: Due to the lack of written records or inscription, the origin and affiliation of Indian Jewish populations with other world populations remain contentious. Previous genetic studies have found evidence for a minor shared ancestry of Indian Jewish with Middle Eastern (Jewish) populations. However, these studies (relied on limited individuals), haven't explored the detailed temporal and spatial admixture process of Indian Jewish populations with the local Indian populations. Here, using large sample size with combination of high resolution biparental (autosomal) and uniparental markers (Y chromosome and mitochondrial DNA), we reconstructed genetic history of Indian Jewish by investigating the patterns of genetic diversity. Consistent with the previous observations, we detected minor Middle Eastern specific ancestry component among Indian Jewish communities, but virtually negligible in their local neighbouring Indian populations. The temporal test of admixture suggested that the first admixture of migrant Jewish populations from Middle East to South India (Cochin) occurred during fifth century. Overall, we concluded that the Jewish migration and admixture in India left a record in their genomes, which can link them to the 'Jewish Diaspora'.
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.|Department of Evolutionary Biology, Estonian Biocentre, Riia23b, Tartu, Estonia-51010.
authors.forename: Gyaneshwer
authors.initials: G
authors.lastname: Chaubey
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
authors.forename: Manvendra
authors.initials: M
authors.lastname: Singh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
authors.forename: Niraj
authors.initials: N
authors.lastname: Rai
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.|Department of Anatomy, Amala Institute of Medical Sciences, Thrissur-680555, India.
authors.forename: Mini
authors.initials: M
authors.lastname: Kariappa
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
authors.forename: Kamayani
authors.initials: K
authors.lastname: Singh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Singh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
authors.forename: Deepankar
authors.initials: D
authors.lastname: Pratap Singh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Tamang
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
authors.forename: Deepa
authors.initials: D
authors.lastname: Selvi Rani
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
authors.forename: Alla G
authors.initials: AG
authors.lastname: Reddy
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Kumar Singh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.|Genome Foundation, Hyderabad 500007, India.
authors.forename: Lalji
authors.initials: L
authors.lastname: Singh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
authors.forename: Kumarasamy
authors.initials: K
authors.lastname: Thangaraj
mesh_terms: D041322:Chromosomes, Human, Y; D004272:DNA, Mitochondrial / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005819:Genetic Markers; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007194:India; D007585:Jews / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis
chemical_list: D004272:DNA, Mitochondrial; D005819:Genetic Markers