title: The Effect of Atorvastatin on Preventing Noise-Induced Hearing Loss: An Experimental Study.
abstract: Noise-induced hearing loss (NIHL) is a common, irreversible occupational disease. Statins have recently been proposed to prevent NIHL.
  
  
  
  To assess the effect of atorvastatin for the prevention of NIHL in rats.
  
  
  
  In this experimental study, forty 2-3-month-old Wistar male rats were divided into 5 groups of 8 animals. 3 groups of rats received atorvastatin at doses of 5, 25, and 50 mg/kg daily for 14 days. The 4th group of rats received normal saline; another group was the control group. After 2 weeks of treatment, the rats were exposed to broad-band noise (125-20 000 Hz) at 110 dB-SPL intensity for 2 hours. Response amplitude of all ears at 5 frequencies was assessed by distortion product otoacoustic emissions (DP-OAE) at baseline, 2 hours, and 2 weeks after the exposure.
  
  
  
  Response amplitude was significantly decreased at all frequencies immediately after exposure to noise in all studied groups. The amplitude increased after 72 hours to a level higher than temporary threshold shift (TTS); this change was only significant in the group received 5 mg/kg atorvastatin.
  
  
  
  Low dose atorvastatin (5 mg/kg) used before exposure to noise can probably prevent NIHL in rats. This effect was not observed with higher doses of the drug.
authors.affiliation: Department of Occupational Medicine, Sadoughi University of Medical Sciences, Yazd, Iran. mdjahani@yahoo.com.
authors.forename: L
authors.initials: L
authors.lastname: Jahani
authors.forename: A H
authors.initials: AH
authors.lastname: Mehrparvar
authors.forename: M
authors.initials: M
authors.lastname: Esmailidehaj
authors.forename: M E
authors.initials: ME
authors.lastname: Rezvani
authors.forename: B
authors.initials: B
authors.lastname: Moghbelolhossein
authors.forename: Z
authors.initials: Z
authors.lastname: Razmjooei
mesh_terms: D000818:Animals; D000069059:Atorvastatin / Q000008:administration & dosage* / Q000494:pharmacology; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D009622:Noise / Q000009:adverse effects; D009784:Occupational Diseases / Q000188:drug therapy / Q000517:prevention & control; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000069059:Atorvastatin