title: Are the Dysnatremias a Permanent Threat to the Critically Ill Patients?
abstract: BACKGROUND
  The dysnatremias (hyponatremia and hypernatremia) are relatively common findings on admission of intensive care unit (ICU) patients and may represent a major risk. The aim of the study was to assess the ability of serum sodium levels and the Acute Physiology and Chronic Health Evaluation II (APACHE II) to predict mortality of surgical critically ill patients.
  
  
  METHODS
  One hundred and ninety-five surgical patients (62% males and 38% females; mean age of 51.8 ± 17.3 years) admitted to the ICU in the postoperative phase were retrospectively studied. The patients were divided into survivors (n = 152) and non-survivors (n = 43). APACHE II, and serum sodium levels at admission, 48 h and discharge were analyzed by generation of receiver operating characteristic (ROC) curves.
  
  
  RESULTS
  The mean APACHE II was 16.3 ± 8.3 (13.6 ± 6.1 for survivors and 25.5 ± 8.5 for non-survivors). The area under the ROC curve for APACHE II was 0.841 (0.782 - 0.889) and 0.721 (0.653 - 0.783), 0.754 (0.653 - 0.783) and 0.720 (0.687 - 0.812) for serum sodium level at admission, 48 h and discharge, respectively.
  
  
  CONCLUSIONS
  Even though APACHE II scoring system was the most effective index to predict mortality in the surgical critically ill patients, the serum sodium levels on admission may also be used as an independent predictor of outcome.
authors.affiliation: Division of Intensive Care, Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, SP 14049-900 Ribeirao Preto, Brazil.
authors.forename: Anibal
authors.initials: A
authors.lastname: Basile-Filho
authors.affiliation: Division of Intensive Care, Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, SP 14049-900 Ribeirao Preto, Brazil.
authors.forename: Mayra Goncalves
authors.initials: MG
authors.lastname: Menegueti
authors.affiliation: Division of Intensive Care, Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, SP 14049-900 Ribeirao Preto, Brazil.
authors.forename: Edson Antonio
authors.initials: EA
authors.lastname: Nicolini
authors.affiliation: Division of Intensive Care, Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, SP 14049-900 Ribeirao Preto, Brazil.
authors.forename: Alessandra Fabiane
authors.initials: AF
authors.lastname: Lago
authors.affiliation: Department of Social Medicine (Statistics), Ribeirao Preto Medical School, University of Sao Paulo, SP 14049-900 Ribeirao Preto, Brazil.
authors.forename: Edson Zangiacomi
authors.initials: EZ
authors.lastname: Martinez
authors.affiliation: Division of Intensive Care, Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, SP 14049-900 Ribeirao Preto, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: Auxiliadora-Martins
keywords: APACHE; Hypernatremia; Hyponatremia; Intensive care; Mortality