title: Tubular and glomerular kidney effects in the Chinese general population with low environmental cadmium exposure.
abstract: Cadmium (Cd), a well-known nephrotoxic agent, has received a great deal of attention from the Chinese public because of reports of its presence in rice. But very few studies have assessed the renal risk of Cd exposure in children. In this cross-sectional study, we aimed to determine whether biologic measures of Cd exposure were associated with biomarkers of early kidney damage in children, adolescents and adults. A total of 1235 subjects (2-86.8 years old) participated in this study and provided samples of blood and urine. As a result, the median urinary Cd level was 0.38 μg g(-1) creatinine in adult men and 0.42 μg g(-1) creatinine in adult women, similar to reference values observed in the United States (median: 0.32-0.40 μg L(-1) in adults). Multiple linear regressions showed Cd in urine to be significantly positively associated with effects on renal tubule biomarkers (as indicated by increased levels of N-acetyl-β-D-glucosaminidase and β2-microglobulin) after adjusting for age, body mass index, blood lead, and urinary density, in all age groups including children. We also found positive associations between blood Cd and renal tubule biomarkers in children. In conclusion, adverse tubular renal effects might have occurred at the current low Cd levels in the study population, including children. These findings are particularly relevant assessing health risks associated with low environmental exposures to Cd.
authors.affiliation: Changshu Center for Disease Prevention and Control, Suzhou 510000, Jiangsu, China.
authors.forename: Dongyue
authors.initials: D
authors.lastname: Wang
authors.affiliation: Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, Jiangsu, China. Electronic address: njmu_sunhong@hotmail.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Sun
authors.affiliation: Changshu Center for Disease Prevention and Control, Suzhou 510000, Jiangsu, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Changshu Center for Disease Prevention and Control, Suzhou 510000, Jiangsu, China.
authors.forename: Zhengyuan
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, Jiangsu, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, Jiangsu, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, Jiangsu, China. Electronic address: cdcxy@vip.sina.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000118:Acetylglucosaminidase / Q000097:blood / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002104:Cadmium / Q000097:blood / Q000633:toxicity* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D002681:China; D003404:Creatinine / Q000097:blood / Q000652:urine; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity* / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects / Q000378:metabolism; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012275:Oryza / Q000737:chemistry; D012016:Reference Values; D018570:Risk Assessment; D055815:Young Adult; D001613:beta 2-Microglobulin / Q000097:blood / Q000652:urine
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D001613:beta 2-Microglobulin; D002104:Cadmium; D003404:Creatinine; D000118:Acetylglucosaminidase
keywords: Cadmium; Children; General population; Glomerular effects; Tubular effects