title: Circulating serum levels of angiopoietin-1 and angiopoietin-2 in nasopharynx and larynx carcinoma patients.
abstract: We aimed to determine the serum levels of angiogenic factors, namely angiopoietins, in nasopharyngeal and laryngeal carcinoma patients. We also aimed to seek the relation of these molecules with tumor grade and their utility as diagnostic biomarkers. We evaluated angiopoietin 1 and 2 levels innasopharynx and larynx cancer patients before treatment. Angiopoietin 2 levels were significantly elevated in larynx carcinoma patients and tended to be elevated in nasopharynx cancer patients compared with healthy controls. However, angiopoietin 1 levels were similar in cancer patients and controls. Angiopoietin 1 levels were significantly higher in nasopharyngeal cancer patients with advanced stages compared to earlier stages. On the other hand, angiopoietin 2 levels were similar in advanced and earlier stage cancer patients.
authors.affiliation: Istanbul University Oncology Institute, Istanbul, Turkey. meguveli@gmail.com.
authors.forename: Murat Emin
authors.initials: ME
authors.lastname: Güveli
authors.affiliation: Istanbul University Oncology Institute, Istanbul, Turkey. duranyildiz@yahoo.com.
authors.forename: Derya
authors.initials: D
authors.lastname: Duranyildiz
authors.affiliation: Istanbul University Oncology Institute, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karadeniz
authors.affiliation: Istanbul University Oncology Institute, Istanbul, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Bilgin
authors.affiliation: Istanbul University Oncology Institute, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Serilmez
authors.affiliation: Istanbul University Oncology Institute, Istanbul, Turkey.
authors.forename: Hilal Oguz
authors.initials: HO
authors.lastname: Soydinc
authors.affiliation: Istanbul University Oncology Institute, Istanbul, Turkey.
authors.forename: Vildan
authors.initials: V
authors.lastname: Yasasever
mesh_terms: D042683:Angiopoietin-1 / Q000097:blood*; D042702:Angiopoietin-2 / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D002277:Carcinoma / Q000097:blood* / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: C467630:ANGPT1 protein, human; D042683:Angiopoietin-1; D042702:Angiopoietin-2; D014408:Biomarkers, Tumor
keywords: Angiopoietins; Larynx cancer; Nasopharynx cancer