title: Tumor vascularity and lipiodol deposition as early radiological markers for predicting risk of disease progression in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization.
abstract: This study evaluated the factors impacting overall survival (OS) and time to progression (TTP) in patients with unresectable hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE). HCC patients were grouped based on tumor vascularity and lipidiol deposition after TACE. Tumor vascularity was classified based on contrast enhancement on arterial phase baseline CT scans. Lipiodol deposition was evaluated using CT scans. The progression-free rate was significantly higher in patients with good blood supply + good lipiodol deposition compared to those with good blood supply + poor lipiodol deposition. In patients with poor lipidiol deposition, risk of death was significantly positively correlated with stage, and negatively correlated with number of TACE procedures and degree of lipidiol deposition after the first TACE. Risk of disease progression in these patients was positively correlated with tumor size, and negatively correlated with number of TACE procedures and degree of lipidiol deposition after the first TACE. Our data showed that tumor vascularity and lipiodol deposition can be used as early radiological markers to identify patients who do not respond to TACE, and who can be considered earlier for alternative combination treatment strategies. Our data also indicated that poor lipiodol retention may predict a poor TTP and OS despite the blood supply status.
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Cheng-Shi
authors.initials: CS
authors.lastname: Chen
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Fang-Kun
authors.initials: FK
authors.lastname: Li
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Chen-Yang
authors.initials: CY
authors.lastname: Guo
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Jin-Cheng
authors.initials: JC
authors.lastname: Xiao
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Hu
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Cheng
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Deng-Wei
authors.initials: DW
authors.lastname: Zong
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Ma
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou 450008, China.
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Li
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology*; D016461:Chemoembolization, Therapeutic; D018450:Disease Progression; D004998:Ethiodized Oil / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D047368:Tumor Burden
chemical_list: D004998:Ethiodized Oil
keywords: hepatocellular carcinoma; lipiodol; overall survival; transarterial chemoembolization; tumor vascularity