title: Prognostic significance of Glasgow prognostic score in patients with stage II colorectal cancer.
abstract: Glasgow prognostic score (GPS), one information based prognostic score, has been previously shown to be a prognostic factor in varieties cancers mostly in advanced tumors. This study aimed to explore its value in patients with relatively early stage colorectal cancer (CRC). A total of 99 CRC patients with stage II from 2005 to 2010 operated in our hospital were enrolled in this study. C-reactive protein (CRP), albumin (ALB), Karnofsky Performance Status (KPS) score as well as a variety of biochemical variables before the operation was acquired from the database retrospectively. The value of GPS was calculated and its association with the clinical factors was further investigated. The prognostic significance was analyzed by univariate and multivariate analyses. Increased preoperative GPS was found associated with elevated carcinoembryonic antigen (CEA) and decreasing of KPS. Kaplan-Meier analysis and log-rank test revealed that a higher GPS predicted a higher risk of postoperative mortality in stage II CRC (P < 0.001). Furthermore, multivariate analysis demonstrated the GPS to be a risk factor for postoperative mortality (HR 3.215; P=0.025). The preoperative GPS might be a potential useful indicator for postoperative survival in patients with stage II CRC.
authors.affiliation: Department of Gastroenterology, Taizhou People's Hospital Taizhou, Jiangsu Province, P. R. China.
authors.forename: Mao-Song
authors.initials: MS
authors.lastname: Lin
authors.affiliation: Department of Oncology, Taizhou People's Hospital Taizhou, Jiangsu Province, P. R. China.
authors.forename: Jun-Xing
authors.initials: JX
authors.lastname: Huang
authors.affiliation: Department of Pathology, Taizhou People's Hospital Taizhou, Jiangsu Province, P. R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
keywords: CEA; Glasgow prognostic score; KPS; colorectal cancer; prognosis