title: [Influence of proton pump inhibitors on intestinal fermentative profile: a case-control study].
abstract: BACKGROUND
  Proton pump inhibitors could have an impact on the results of breath tests performed in patients with irritable bowel syndrome. This impact could be due to the development of small intestine bacterial overgrowth.
  
  
  OBJECTIVE
  To compare the prevalence of fermentative profile alterations of irritable bowel syndrome patients exposed and not-exposed to proton pump inhibitor therapy.
  
  
  METHODS
  Subjects with irritable bowel syndrome were enrolled. A validated questionnaire assessing symptom severity as well as proton pump inhibitor treatment was delivered. A lactulose breath test was undertaken by each enrolled subject. Fermentative profile (area under the curve of hydrogen excretion/time) was compared between proton pump inhibitors consumers and non-consumers. Furthermore, small intestine bacterial overgrowth prevalence was compared.
  
  
  RESULTS
  Two hundred and twenty five patients were enrolled. No significant differences were found on the fermentative profile between groups [AUC mediana 3,776 (rango 2,124-5,571) vs 4,347 (rango 2,038-5,481), P = 0.3]. Small intestine bacterial overgrowth prevalence was similar as well [33% vs 27.5%]. These differences remained non-significant after adjusting for proton pump inhibitor dose and treatment time. Surprisingly, symptom score was significantly higher in those patients under proton pump inhibitor therapy [28.5 (23-26) vs 23 (15-29), P = 0.01].
  
  
  CONCLUSIONS
  Proton pump inhibitors have no significant influence on lactulose breath tests, regardless of the dosage and time of administration.
authors.forename: Melisa
authors.initials: M
authors.lastname: Senderovky
authors.forename: Juan
authors.initials: J
authors.lastname: Lasa
authors.forename: Guillermo
authors.initials: G
authors.lastname: Dima
authors.forename: Daniel
authors.initials: D
authors.lastname: Peralta
authors.forename: Mariano
authors.initials: M
authors.lastname: Argüello
authors.forename: Luis
authors.initials: L
authors.lastname: Soifer
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001944:Breath Tests; D016022:Case-Control Studies; D005260:Female; D005285:Fermentation / Q000187:drug effects*; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000188:drug therapy* / Q000382:microbiology; D007792:Lactulose / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*; D011795:Surveys and Questionnaires
chemical_list: D054328:Proton Pump Inhibitors; D007792:Lactulose