title: Lipid Metabolites from the Mushroom Meripilus giganteus.
abstract: The phytochemical investigation of the methanolic extract of the white rot fungus Meripilus giganteus resulted in the isolation and identification of complex mixtures of free fatty acids (1), monoacylglycerols (2), cerebrosides (3), ergosterol (4) and ergosterol peroxide (5). The structures of the isolated lipid metabolites (1-5) were determined by chemical and spectroscopic methods. The antioxidant activity of the whole MeOH extract of the fungus was evaluated through in vitro model systems, such as 2,2-diphenyl-l-picrylhydrazyl (DPPH) and superoxide anion. In all two systems, the results indicated that the extract of the fungus showed the same free-radical-scavenging activity with SC50 data of 47.70 µg/mL, compared with the positive control quercetin (DPPH assay). None of the isolated compounds (1-5) showed a significant activity. Compounds 2-4 were isolated from Meripilus giganteus for the first time.
authors.forename: Francesca
authors.initials: F
authors.lastname: Catenia
authors.forename: Tiziano
authors.initials: T
authors.lastname: Altieri
authors.forename: Marina
authors.initials: M
authors.lastname: Zacchigna
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Procida
authors.forename: Jelena
authors.initials: J
authors.lastname: Zilic
authors.forename: Dusan
authors.initials: D
authors.lastname: Zigon
authors.forename: Angelo
authors.initials: A
authors.lastname: Cichelli
mesh_terms: D000363:Agaricales / Q000737:chemistry / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000378:metabolism; D014675:Vegetables / Q000737:chemistry*
chemical_list: D008055:Lipids; D010936:Plant Extracts