title: Prognostic value of Ki67 and p63 expressions in bladder cancer patients who underwent radical cystectomy.
abstract: BACKGROUND
  Radical cystectomy (RC) is the gold standard treatment for patients with high-risk non-muscle-invasive bladder cancer and muscle-invasive bladder cancer (MIBC) . However, despite aggressive treatment, mortality rates of patients are still high. Therefore, it is crucial to indentify some practical prognostic factors for cancer-specific survival in those patients to guide our therapeutic strategies.
  
  
  METHODS
  We included 103 patients treated with RC for urothelial bladder cancer (UBC) between July 2007 and June 2014 in our institution and analyzed their clinicopathological parameters. The mean follow-up was 22 months (range 2-89 months).
  
  
  RESULTS
  Advanced tumor T stage, N stage, ABO blood type, a history of DM and positive p63 expression were independent factors for worse survival in all patients who underwent RC. Moreover, in female gender, high Ki67 expression was significant risk factor for cancer-specific survival (CSS) in MIBC patients.
  
  
  CONCLUSIONS
  Our study demonstrated that immunohistochemical expressions of Ki67 and p63 are potential prognostic factors for UBC patients who underwent RC.
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
authors.forename: Lujia
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
authors.forename: Minwei
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Feng
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
authors.forename: Guanxiong
authors.initials: G
authors.lastname: Ding
authors.affiliation: Department of Pathology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
authors.forename: Haowen
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China. qiangding63@126.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D015653:Cystectomy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; D019394:Ki-67 Antigen; D008565:Membrane Proteins
keywords: Bladder cancer; Ki67; Radical cystectomy; p63