title: Immunohistochemical Expression of Progesterone Receptors in Nonmeningothelial Central Nervous System Tumors.
abstract: Immunostaining of progesterone receptors (PRs) has been described as a prognostic factor related to recurrences in meningiomas. However, its expression in other primary intracranial tumors has been poorly studied. In this paper, we compare the pattern of expression of the receptor in meningiomas with that of nonmeningothelial intracranial tumors to evaluate its value in the diagnosis of the former.
  
  
  
  A total of 42 nonmeningothelial intracranial tumors (21 glioblastomas, 4 anaplastic oligodendrogliomas, 4 oligodendrogliomas, 1 pilomyxoid astrocytoma, 3 ependymomas, 8 schwannomas, 1 chordoid chordoma) and 32 meningiomas (1 rhabdoid, 1 papillary, 5 atypical, 7 with histologic features of more aggressive behavior, 1 microcyst, 8 meningothelial, 7 transitional, 2 fibroblastic) were studied for PR by immunohistochemistry.
  
  
  
  About 73.8% of the nonmeningothelial tumors and 100% of the meningiomas were positive for the receptor, the difference being statistically significant (P=0.0017). The mean percentage of positive tumor cells per high-power field was frequently higher than 30% in meningiomas and lower than 10% in nonmeningothelial tumors (P=0.0001).
  
  
  
  Although we detected that immunostaining for the PR is more frequently observed in meningiomas, we confirmed its expression in diverse nonmeningothelial primary intracranial tumors. Immunohistochemistry for PR would be useful in the diagnosis of meningioma only when its positivity shows a mean higher than 30% of the positive tumor cells per high-power field.
authors.affiliation: *Department of Pathology †Committee of Teaching and Research, Hospital Ignacio Pirovano, Buenos Aires, Argentina.
authors.forename: Mónica B
authors.initials: MB
authors.lastname: Mezmezian
authors.forename: Mónica
authors.initials: M
authors.lastname: B Carassai
authors.forename: Valeria
authors.initials: V
authors.lastname: Dopazo
authors.forename: María L
authors.initials: ML
authors.lastname: Deforel
authors.forename: María Á
authors.initials: MÁ
authors.lastname: Puzzo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016543:Central Nervous System Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011980:Receptors, Progesterone / Q000378:metabolism*; D055815:Young Adult
chemical_list: D011980:Receptors, Progesterone