title: Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway.
abstract: NF-κB pathway has long been considered as one of the potent prototypical pro-inflammatory signaling pathway and its role in several aspects of human health has been established. Recent studies have suggested that NF-κB activation is the master key in early development and pathobiology of several Cancers. Curcumin is a polyphenolic phytochemical compound with several stablished anti-inflammatory properties and is known to exert its anti-inflammatory effects mostly by interrupting NF-κB signaling pathway at multiple stages. Here we tried to provide a summary of recent finding, focusing on introducing NF-κB signaling pathways and its potential mechanism involved in development of several types of Cancers.
authors.affiliation: Novel Drug Delivery Lab, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Yunes
authors.initials: Y
authors.lastname: Panahi
authors.affiliation: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Nanotechnology Research center, Faculty of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran. Electronic address: chopin1827@yahoo.com.
authors.forename: Behrad
authors.initials: B
authors.lastname: Darvishi
authors.affiliation: Novel Drug Delivery Lab, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Ghanei
authors.affiliation: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Nanotechnology Research center, Faculty of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran.
authors.forename: Narges
authors.initials: N
authors.lastname: Jowzi
authors.affiliation: Nephrology and Urology research center, Baqiyatallah medical science university, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Beiraghdar
authors.affiliation: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Nanotechnology Research center, Faculty of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran.
authors.forename: Behrang Shiri
authors.initials: BS
authors.lastname: Varnamkhasti
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D063646:Carcinogenesis / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology*; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D016328:NF-kappa B; D003474:Curcumin
keywords: Cancer; Curcumin; Inflammation; NF-κB