title: Venous access for hematopoietic progenitor cell collection: An international survey by the ASFA HPC donor subcommittee.
abstract: OBJECTIVE
  Hematopoietic Progenitor Cell (HPC) collection by apheresis is performed in patients and donors to obtain HPCs for transplantation. Although studies have shown these procedures to be safe, successful collection cannot be performed without establishment of venous access. This project's objective was to ascertain the current practices of donor vein assessment and central venous catheter (CVC) usage.
  
  
  METHODS
  The American Society for Apheresis (ASFA) HPC subcommittee created an electronic survey about precollection vein assessment and line placement, care, and removal in autologous and allogeneic donors. It was distributed to >5,000 possible participants, with one response analyzed per institution.
  
  
  RESULTS
  One hundred centers performing autologous and/or allogeneic procedures provided adequate responses for analysis. Donor vein assessment is most often performed by apheresis staff more than 1 week prior to collection. For patients with questionable access, the next step performed most often is secondary assessment for autologous procedures and CVC placement for allogeneic procedures. Most centers use interventional radiology to place CVCs in jugular veins on collection day with placement verification through electronic medical records. Verbal and written postinsertion CVC care instructions are routinely provided. The apheresis team frequently provides postinsertion CVC care for autologous patients. Heparin is used most often for CVC lock. When used, tissue plasminogen activator is usually instilled for up to 60 min.
  
  
  CONCLUSIONS
  These data summarize the largest single survey of donor vein assessment at institutions performing HPC collections by apheresis. The variations identified in donor venous access practice warrant further investigation and consensus to establish best practices. J. Clin. Apheresis 31:529-534, 2016. © 2015 Wiley Periodicals, Inc.
authors.affiliation: University Medical Center New Orleans, New Orleans, Louisiana.|The Blood Center, New Orleans, Louisiana.|Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
authors.forename: Mandy Flannery
authors.initials: MF
authors.lastname: O'Leary
authors.affiliation: Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Dunbar
authors.affiliation: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.|Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Haewon C
authors.initials: HC
authors.lastname: Kim
authors.affiliation: University of Colorado Hospital, Aurora, Colorado.|Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Draper
authors.affiliation: Department of Medicine, Division of Hematology, University of Washington, Seattle, Washington.|Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.|Seattle Cancer Care Alliance, Seattle, Washington.
authors.forename: Michael
authors.initials: M
authors.lastname: Linenberger
authors.affiliation: Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
authors.forename: Joseph
authors.initials: J
authors.lastname: Schwartz
authors.affiliation: American Red Cross, Donor and Client Support Center, Charlotte, North Carolina.
authors.forename: Yvette
authors.initials: Y
authors.lastname: Miller
authors.affiliation: Seattle Cancer Care Alliance, Seattle, Washington.
authors.forename: Ally
authors.initials: A
authors.lastname: Murtaugh
authors.affiliation: New York Medical College, Valhalla, New York.
authors.forename: F Bernadette
authors.initials: FB
authors.lastname: West
authors.affiliation: Davis Medical Center, University of California, Sacramento, California.
authors.forename: Leonor P
authors.initials: LP
authors.lastname: Fernando
authors.affiliation: The Blood Center, New Orleans, Louisiana.|Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Yara A
authors.initials: YA
authors.lastname: Park
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000379:methods; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006306:Health Surveys; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D012955:Societies, Medical; D014019:Tissue Donors; D014680:Veins / Q000187:drug effects / Q000473:pathology
chemical_list: D005343:Fibrinolytic Agents
keywords: Apheresis; HPC; Venous Access; stem cell collection