title: Wide field of view swept-source optical coherence tomography for peripheral retinal disease.
abstract: OBJECTIVE
  To assess peripheral retinal lesions and the posterior pole in single widefield optical coherence tomography (OCT) volumes.
  
  
  METHODS
  A wide field of view (FOV) swept-source OCT (WFOV SSOCT) system was developed using a commercial swept-source laser and a custom sample arm consisting of two indirect ophthalmic lenses. Twenty-seven subjects with peripheral lesions (choroidal melanomas, choroidal naevi, sclerochoroidal calcification, retinitis pigmentosa, diabetic retinopathy, retinoschisis and uveitis) were imaged with the WFOV SSOCT. Volumes were taken in primary gaze. Using the optic nerve to fovea distance as a reference measurement, comparisons were made between the lateral FOV of the WFOV SSOCT, current generation spectral-domain OCT (SDOCT) and widefield scanning laser ophthalmoscopy (SLO) of the same eyes.
  
  
  RESULTS
  Peripheral pathologies were captured with WFOV SSOCT in 26 of the 27 subjects. The one not captured was in the far nasal periphery and was not seen in the primary gaze volume. Posterior pole associated pathologies were captured in all subjects. Current generation SDOCT had a mean lateral FOV of 2.08±0.21 optic nerve to fovea distance units, WFOV SSOCT had an FOV of 4.62±0.62 units and SLO had an FOV of 9.35±1.02 units.
  
  
  CONCLUSIONS
  WFOV OCT can be used to examine both peripheral retinal pathology and the posterior pole within a single volume acquisition. SLO had the greatest FOV, but does not provide depth information. Future studies using widefield OCT systems will help further delineate the role of WFOV OCT to quantitatively assess and monitor peripheral retinal disease in three dimensions.
authors.affiliation: Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Ryan P
authors.initials: RP
authors.lastname: McNabb
authors.affiliation: Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Dilraj S
authors.initials: DS
authors.lastname: Grewal
authors.affiliation: Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Rajvi
authors.initials: R
authors.lastname: Mehta
authors.affiliation: Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Stefanie G
authors.initials: SG
authors.lastname: Schuman
authors.affiliation: Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Izatt
authors.affiliation: Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Tamer H
authors.initials: TH
authors.lastname: Mahmoud
authors.affiliation: Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Glenn J
authors.initials: GJ
authors.lastname: Jaffe
authors.affiliation: Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Prithvi
authors.initials: P
authors.lastname: Mruthyunjaya
authors.affiliation: Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Kuo
mesh_terms: D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012160:Retina / Q000000981:diagnostic imaging*; D012164:Retinal Diseases / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: Imaging; Retina