title: Proton Pump Inhibitor Prophylaxis After Gastric Bypass Does Not Cause Hypomagnesemia.
abstract: Proton pump inhibitor (PPI)-induced hypomagnesemia is currently a major topic. Patients undergoing Roux-en-Y gastric bypass are generally prescribed PPI prophylaxis after surgery. We investigated the prevalence of hypomagnesemia in our bariatric population. We reviewed the files of 1000 postoperative patients for serum magnesium level during PPI use. We found only five cases of hypomagnesemia, none of which was evidently related to PPI use. We conclude that the risk of hypomagnesemia during 1 year of prophylactic PPI use after Roux-en-Y gastric bypass (RYGB) is minimal and laboratory screening is probably not necessary.
authors.affiliation: Department of Internal Medicine, MC Slotervaart, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. thomas.boerlage@slz.nl.
authors.forename: Thomas C C
authors.initials: TC
authors.lastname: Boerlage
authors.affiliation: Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute/MC Slotervaart, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands. Charlotte@tangeborg.nl.
authors.forename: Charlotte L E
authors.initials: CL
authors.lastname: van Hees
authors.affiliation: Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute/MC Slotervaart, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands. A.Huitema@nki.nl.
authors.forename: Alwin D R
authors.initials: AD
authors.lastname: Huitema
authors.affiliation: Department of Internal Medicine, MC Slotervaart, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. Fanny.Lauw@slz.nl.
authors.forename: Fanny N
authors.initials: FN
authors.lastname: Lauw
mesh_terms: D000328:Adult; D005260:Female; D015390:Gastric Bypass / Q000009:adverse effects*; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors; D008274:Magnesium
keywords: Gastric bypass; Hypomagnesemia; Proton pump inhibitor