title: New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.
abstract: Corticosteroid-binding globulin (CBG) is the specific plasma transport glycoprotein for glucocorticoids. Circulating CBG is mainly synthesized in liver but, its synthesis has been located also in other organs as placenta, kidney and adipose tissue with unknown role. Using an experimental model of acute pancreatitis in cbg-/- mice we investigated whether changes in CBG affect the progression of the disease as well as the metabolism of glucocorticoids in the lung. Lack of CBG does not modify the progression of inflammation associated to pancreatitis but resulted in the loss of gender differences in corticosterone serum levels. In the lung, CBG expression and protein level were detected, and it is noteworthy that these showed a sexual dimorphism opposite to the liver, i.e. with higher levels in males. Reduced expression of 11β-HSD2, the enzyme involved in the deactivation of corticosterone, was also observed. Our results indicate that, in addition to glucocorticoids transporter, CBG is involved in the gender differences observed in corticosteroids circulating levels and plays a role in the local regulation of corticosteroids availability in organs like lung.
authors.affiliation: Department of Nutrition and Food Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.|CIBER Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Gulfo
authors.affiliation: Department of Nutrition and Food Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.|CIBER Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
authors.forename: Angelo
authors.initials: A
authors.lastname: Ledda
authors.affiliation: Department of Experimental Pathology, IIBB-CSIC-IDIBAPS, Barcelona, Spain.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Gea-Sorlí
authors.affiliation: Department of Experimental Pathology, IIBB-CSIC-IDIBAPS, Barcelona, Spain.
authors.forename: Laia
authors.initials: L
authors.lastname: Bonjoch
authors.affiliation: Department of Experimental Pathology, IIBB-CSIC-IDIBAPS, Barcelona, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Closa
authors.affiliation: Department of Nutrition and Food Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.|CIBER Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Grasa
authors.affiliation: Department of Nutrition and Food Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.|CIBER Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Esteve
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D005260:Female; D008049:Lipase / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D008810:Mice, Inbred C57BL; D009928:Organ Specificity; D010179:Pancreas / Q000201:enzymology; D010195:Pancreatitis / Q000097:blood; D009195:Peroxidase / Q000378:metabolism; D012727:Sex Characteristics; D014156:Transcortin / Q000502:physiology*; D059467:Transcriptome
chemical_list: C534937:Serpina6 protein, mouse; D014156:Transcortin; D009195:Peroxidase; D008049:Lipase; D003345:Corticosterone