title: ROS/oxidative stress signaling in osteoarthritis.
abstract: Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of the population. Its multi-factorial etiology includes oxidative stress and the overproduction of reactive oxygen species, which regulate intracellular signaling processes, chondrocyte senescence and apoptosis, extracellular matrix synthesis and degradation along with synovial inflammation and dysfunction of the subchondral bone. As disease-modifying drugs for osteoarthritis are rare, targeting the complex oxidative stress signaling pathways would offer a valuable perspective for exploration of potential therapeutic strategies in the treatment of this devastating disease.
authors.affiliation: Fourth Department of Trauma and Orthopaedics, Medical School, National and Kapodistrian University of Athens, 'KAT' Hospital, 14561, Kifissia, Athens, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Lepetsos
authors.affiliation: Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. Electronic address: papavas@med.uoa.gr.
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papavassiliou
mesh_terms: D000818:Animals; D016922:Cellular Senescence; D019902:Chondrocytes / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D010003:Osteoarthritis / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species
keywords: Cartilage; Chondrocytes; NO; Osteoarthritis; Oxidative stress; Reactive oxygen species