title: Abdominal CT Does Not Improve Outcome for Children with Suspected Acute Appendicitis.
abstract: BACKGROUND
  Acute appendicitis in children is a clinical diagnosis, which often requires preoperative confirmation with either ultrasound (US) or computed tomography (CT) studies. CTs expose children to radiation, which may increase the lifetime risk of developing malignancy. US in the pediatric population with appropriate clinical follow up and serial exam may be an effective diagnostic modality for many children without incurring the risk of radiation. The objective of the study was to compare the rate of appendiceal rupture and negative appendectomies between children with and without abdominal CTs; and to evaluate the same outcomes for children with and without USs to determine if there were any associations between imaging modalities and outcomes.
  
  
  METHODS
  We conducted a retrospective chart review including emergency department (ED) and inpatient records from 1/1/2009-2/31/2010 and included patients with suspected acute appendicitis.
  
  
  RESULTS
  1,493 children, aged less than one year to 20 years, were identified in the ED with suspected appendicitis. These patients presented with abdominal pain who had either a surgical consult or an abdominal imaging study to evaluate for appendicitis, or were transferred from an outside hospital or primary care physician office with the stated suspicion of acute appendicitis. Of these patients, 739 were sent home following evaluation in the ED and did not return within the subsequent two weeks and were therefore presumed not to have appendicitis. A total of 754 were admitted and form the study population, of which 20% received a CT, 53% US, and 8% received both. Of these 57%, 95% CI [53.5,60.5] had pathology-proven appendicitis. Appendicitis rates were similar for children with a CT (57%, 95% CI [49.6,64.4]) compared to those without (57%, 95% CI [52.9,61.0]). Children with perforation were similar between those with a CT (18%, 95% CI [12.3,23.7]) and those without (13%, 95% CI [10.3,15.7]). The proportion of children with a negative appendectomy was similar in both groups: CT (7%, 95% CI [2.1,11.9]), US (8%, 95% CI [4.7,11.3]) and neither (12%, 95% CI [5.9,18.1]).
  
  
  CONCLUSIONS
  In this uncontrolled study, the accuracy of preoperative diagnosis of appendicitis and the incidence of pathology-proven perforation appendix were similar for children with suspected acute appendicitis whether they had CT, US or neither imaging, in conjunction with surgical consult. The imaging modality of CT was not associated with better outcomes for children presenting to the ED with suspected appendicitis.
authors.affiliation: Connecticut Children's Medical Center, Department of Research, Hartford, Connecticut; University of Connecticut School of Medicine, Farmington, Connecticut.
authors.forename: Danielle I
authors.initials: DI
authors.lastname: Miano
authors.affiliation: Connecticut Children's Medical Center, Department of Research, Hartford, Connecticut.
authors.forename: Renee M
authors.initials: RM
authors.lastname: Silvis
authors.affiliation: Connecticut Children's Medical Center, Department of Research, Hartford, Connecticut.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Popp
authors.affiliation: Connecticut Children's Medical Center, Department of Emergency Medicine, Hartford, Connecticut.
authors.forename: Marvin C
authors.initials: MC
authors.lastname: Culbertson
authors.affiliation: Connecticut Children's Medical Center, Department of Surgery, Hartford, Connecticut.
authors.forename: Brendan
authors.initials: B
authors.lastname: Campbell
authors.affiliation: Connecticut Children's Medical Center, Department of Emergency Medicine, Hartford, Connecticut.
authors.forename: Sharon R
authors.initials: SR
authors.lastname: Smith
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D017677:Age Distribution; D001062:Appendectomy / Q000706:statistics & numerical data; D001064:Appendicitis / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D042241:Early Diagnosis; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D004638:Emergency Treatment / Q000706:statistics & numerical data; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011300:Preoperative Care / Q000592:standards; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014504:Urban Health / Q000706:statistics & numerical data; D055815:Young Adult