title: Vaccine-preventable infections in Systemic Lupus Erythematosus.
abstract: Systemic Lupus Erythematosus (SLE) is characterized by abnormal autoantibody production and clearance. Infections are among the most important causes of morbidity and mortality in SLE patients; they have an increased frequency of severe bacterial and viral infections possibly due to inherited genetic and immunologic defects and to immunosuppressive therapies. In addition, infectious agents can switch on lupus disease expression and activity. Among the strategies to reduce the risk of infection, vaccination can be considered the most reliable option. Most vaccines are effective and safe in SLE patients, although in certain cases immunogenicity may be sub-optimal and vaccination can trigger a flare. Although these issues are currently unresolved, the risk benefit balance is in favor for vaccination to reduce the risk of infection in SLE patients. In the present review we discuss the preventive strategies currently recommended to reduce bacterial and viral infections in SLE.
authors.affiliation: a Department of Internal Medicine , University of Genoa, Genoa, Italy and Clinical Immunology Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer Research , Genoa , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Murdaca
authors.affiliation: b Department of Health Sciences, University of Genoa , Genoa, Italy and Hygiene Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer Research , Genoa , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Orsi
authors.affiliation: a Department of Internal Medicine , University of Genoa, Genoa, Italy and Clinical Immunology Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer Research , Genoa , Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Spanò
authors.affiliation: b Department of Health Sciences, University of Genoa , Genoa, Italy and Hygiene Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer Research , Genoa , Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Faccio
authors.affiliation: a Department of Internal Medicine , University of Genoa, Genoa, Italy and Clinical Immunology Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer Research , Genoa , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Puppo
authors.affiliation: c Department of Health Sciences, University of Genoa, Genoa , Italy and Occupational Medicine Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer Research , Genoa , Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Durando
authors.affiliation: b Department of Health Sciences, University of Genoa , Genoa, Italy and Hygiene Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer Research , Genoa , Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Icardi
authors.affiliation: b Department of Health Sciences, University of Genoa , Genoa, Italy and Hygiene Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer Research , Genoa , Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Ansaldi
mesh_terms: D001424:Bacterial Infections / Q000453:epidemiology* / Q000517:prevention & control*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D014777:Virus Diseases / Q000453:epidemiology* / Q000517:prevention & control*
chemical_list: D014612:Vaccines
keywords: erythematosus; infections; systemic lupus; vaccine-preventable; vaccines