title: High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study.
abstract: OBJECTIVE
  Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change in joint space width (JSW).
  
  
  METHODS
  A total of 559 men and women over the age of 50 years with clinical knee OA [Kellgren-Lawrence (KL) grade 2-3] were recruited to the placebo arm of the SEKOIA study (98 centers; 18 countries). Minimal tibiofemoral joint space and KL grade on plain radiograph of the knee were assessed at baseline and at yearly followup up to 3 years. In a subset, serial knee MRI examinations were performed. Individuals with a bone marrow lesion (BML) ≥ grade 2 at the tibiofemoral joint at baseline were classified as BML-positive. Relationships between change in JSW and risk factors were assessed using linear regression.
  
  
  RESULTS
  The mean age of study participants was 62.8 (SD 7.5) years and 73% were female; 38.6% had BML. Mean baseline JSW was 3.65 mm. This reduced by 0.18 (0.30) mm/year in men and 0.13 (0.23) mm/year in women. Those with BML had a significantly higher rate of annualized change in JSW; this relationship remained robust after adjustment for age, sex, and baseline KL grade [β = -0.10 (95% CI -0.18, -0.02) mm/yr]. Age, sex, baseline KL grade, and other MRI findings did not influence the rate of change in JSW.
  
  
  CONCLUSIONS
  The rate of change in JSW was similar in men and women. BML on knee MRI predicted the rate of radiographic change in JSW. This relationship was independent of age, sex, and baseline KL grade.
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Mark H
authors.initials: MH
authors.lastname: Edwards
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Camille
authors.initials: C
authors.lastname: Parsons
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Olivier
authors.initials: O
authors.lastname: Bruyère
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Forence
authors.initials: F
authors.lastname: Petit Dop
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Roland
authors.initials: R
authors.lastname: Chapurlat
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Frank W
authors.initials: FW
authors.lastname: Roemer
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Ali
authors.initials: A
authors.lastname: Guermazi
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Souhil
authors.initials: S
authors.lastname: Zaim
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Harry
authors.initials: H
authors.lastname: Genant
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Reginster
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Dennison
authors.affiliation: From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical
authors.forename: Cyrus
authors.initials: C
authors.lastname: Cooper
mesh_terms: D000368:Aged; D002358:Cartilage, Articular / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging*
keywords: JOINT SPACE NARROWING; KNEE; MAGNETIC RESONANCE IMAGING; NATURAL HISTORY; OSTEOARTHRITIS; PROGRESSION; RADIOGRAPHIC