title: A DTI study on the corpus callosum of treatment-naïve boys with 'pure' Tourette syndrome.
abstract: Disturbances in the corpus callosum (CC) indicating altered interhemispheric connectivity have been associated with Tourette syndrome (TS). The objective of the present study was to refine knowledge about interhemispheric connectivity in TS by analyzing four different diffusion tensor imaging (DTI) parameters in a very homogeneous group of treatment-naïve boys with pure TS in comparison to male healthy controls (HC). Fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD) and mean diffusivity (MD) of five CC-segments were assessed from DTI of 26 treatment-naïve boys with pure TS and 24 HC. We observed no group differences in both FA and RD. However, we found a significant effect for AD and a trend for MD, being both reduced in boys with TS in comparison to HC. Moreover, a negative correlation between AD and the Yale Global Tic Severity Scale total score was observed. Reduced AD of the CC in treatment-naïve boys with pure TS in comparison to HC may indicate that significant alterations in white matter microstructure of the CC contribute to tic symptomatology per se and seem not to be related to confounders such as consequences of long-term medication, tic performance or tic suppression.
authors.affiliation: Department of Child and Adolescent Psychiatry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Electronic address: nicole.wolff@uniklinikum-dresden.de.
authors.forename: Nicole
authors.initials: N
authors.lastname: Wolff
authors.affiliation: Department of Child and Adolescent Psychiatry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Ina
authors.initials: I
authors.lastname: Luehr
authors.affiliation: MR-Research in Neurology and Psychiatry, Department of Cognitive Neurology, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Sender
authors.affiliation: Department of Child and Adolescent Psychiatry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ehrlich
authors.affiliation: MR-Research in Neurology and Psychiatry, Department of Cognitive Neurology, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmidt-Samoa
authors.affiliation: MR-Research in Neurology and Psychiatry, Department of Cognitive Neurology, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Dechent
authors.affiliation: Department of Child and Adolescent Psychiatry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Veit
authors.initials: V
authors.lastname: Roessner
mesh_terms: D000293:Adolescent; D016880:Anisotropy; D016022:Case-Control Studies; D002648:Child; D003337:Corpus Callosum / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D019359:Knowledge; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D012959:Socioeconomic Factors; D005879:Tourette Syndrome / Q000473:pathology*; D066127:White Matter / Q000473:pathology*
keywords: Children; Corpus callosum; DTI; Tics; Tourette syndrome