title: Early- vs late-onset subcortical vascular cognitive impairment.
abstract: OBJECTIVE
  To evaluate the differences between early-onset subcortical vascular cognitive impairment (EO-SVCI) and late-onset subcortical vascular cognitive impairment (LO-SVCI) with regard to pathologic burden, structural changes, and cognitive function.
  
  
  METHODS
  We prospectively recruited 142 patients from a single referral center. Patients were divided into EO-SVCI (n = 30, age at onset <65 years) and LO-SVCI (n = 112, age at onset ≥ 65 years) groups. All patients underwent neuropsychological tests, 3T brain MRI, and [(11)C] Pittsburgh compound B (PiB)-PET. We compared pathologic burden such as small vessel disease and amyloid burden; structural changes such as structural network, cortical thickness, and hippocampal volume; and cognitive function between EO-SVCI and LO-SVCI.
  
  
  RESULTS
  EO-SVCI patients had more lacunes, while LO-SVCI patients had higher PiB standardized uptake value ratios. EO-SVCI patients exhibited more severe structural network disruptions in the frontal area, while LO-SVCI patients exhibited more severe cortical and hippocampal atrophy. Although disease severity did not differ between the 2 groups, frontal-executive dysfunction was more severe in EO-SVCI patients.
  
  
  CONCLUSIONS
  EO-SVCI patients showed more vascular related factors, while LO-SVCI patients exhibited more Alzheimer disease-related characteristics. The greater number of lacunes in EO-SVCI might account for the more severe frontal network disruption and frontal-executive dysfunction, while the greater amyloid burden in LO-SVCI might account for the more severe cortical and hippocampal atrophy. Our findings suggest that the age at onset is a crucial factor that determines distinct features in SVCI patients, such as pathologic burden, structural changes, and cognitive function.
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Young Kyoung
authors.initials: YK
authors.lastname: Jang
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Hunki
authors.initials: H
authors.lastname: Kwon
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Yeo Jin
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Na Yeon
authors.initials: NY
authors.lastname: Jung
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jin San
authors.initials: JS
authors.lastname: Lee
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Juyoun
authors.initials: J
authors.lastname: Lee
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Juhee
authors.initials: J
authors.lastname: Chin
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Kiho
authors.initials: K
authors.lastname: Im
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Seun
authors.initials: S
authors.lastname: Jeon
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Joon-Kyoung
authors.initials: JK
authors.lastname: Seong
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jeong Hun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Seonwoo
authors.initials: S
authors.lastname: Kim
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Yearn Seong
authors.initials: YS
authors.lastname: Choe
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Kyung-Han
authors.initials: KH
authors.lastname: Lee
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Kim
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Kim
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Lee
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
authors.affiliation: From the Departments of Neurology (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Nuclear Medicine (Y.S.C., K.-H.L.), and Radiology (S.T.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (Y.K.J., Y.J.K., J.S.L., J.L., J.C., D.L.N., S.W.S., H.J.K.), Samsung Medical Center, Seoul, Korea; Department of Biomedical Engineering (H.K., J.M.L.), Hanyang University, Seoul, Korea; Department of Neurology (N.Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Division of Newborn Medicine (K.I.), Boston Children's Hospital, Harvard Medical School, Boston, MA; McGill Centre for Integrative Neuroscience (S.J.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Departments of Biomedical Engineering (J.-K.S.) and Computer and Radio Communications Engineering (J.H.K.), Korea University; Biostatistics Team (S.K.), Samsung Biomedical Research Institute; and Departments of Nuclear Medicine (J.S.K.) and Neurology (J.H.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. evekhj@gmail.com.
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000378:metabolism; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology*; D003072:Cognition Disorders / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D000682:Amyloid