title: Randomized dose-response study of subcutaneous immunotherapy with a Dermatophagoides pteronyssinus extract in patients with respiratory allergy.
abstract: OBJECTIVE
  To evaluate the efficacy of Dermatophagoides pteronyssinus (DPT) subcutaneous immunotherapy in allergic rhinoconjunctivitis patients.
  
  
  METHODS
  This 17-week double-blind study randomized 136 patients (95 evaluable) to five dose groups of DPT depot extract (0.0625-0.75 skin prick test [SPT] units) or placebo, administered in a six updosing schedule.
  
  
  RESULTS
  A dose-response was observed for clinical efficacy (allergen concentration needed to induce a positive nasal provocation test response from baseline to final visit) and safety (adverse reactions). Local and systemic reactions occurred with 14.8 and 6.4% of administered doses, respectively; a single anaphylactic reaction occurred in each of Groups 3, 4 and 5 (0.3% of doses).
  
  
  CONCLUSIONS
  The risk-benefit profile appeared most favorable with a DPT dose of 0.125 SPT units.
authors.affiliation: Servicio de Alergología, Hospital Blanca Paloma, Huelva, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Moreno
authors.affiliation: Servicio de Alergología, Hospital de Manises, Manises, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Alvariño
authors.affiliation: Servicio de Alergología, Hospital Marqués de Valdecilla, Santander, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodríguez
authors.affiliation: Unidad de Alergología, Hospital Germans Trias i Pujol, Badalona, Spain.
authors.forename: Albert
authors.initials: A
authors.lastname: Roger
authors.affiliation: Servicio de Alergología, Hospital Vega Baja (Orihuela), San Bartolomé, Spain.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Peña-Arellano
authors.affiliation: Servicio de Alergología, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Lleonart
authors.affiliation: Servicio Alergia, Hospital Virgen de la Arrixaca, El Palmar, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Pagán
authors.affiliation: Servicio de Alergología, Hospital Donostia, Donostia, Spain.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Navarro
authors.affiliation: Servicio de Alergología, Hospital Luís Alcanyís, Xátiva, Spain.
authors.forename: Luís Angel
authors.initials: LA
authors.lastname: Navarro
authors.affiliation: Servicio de Alergología, Complejo Hospitalario Universitario de Santiago (Hospital de Conxo), Santiago de Compostela, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Vidal
authors.affiliation: R&D Department, Bial Industrial Farmacéutica S.A., Zamudio, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Ponte-Tellechea
authors.affiliation: R&D Department, Bial Industrial Farmacéutica S.A., Zamudio, Spain.
authors.forename: María Cruz
authors.initials: MC
authors.lastname: Gómez-Fernández
authors.affiliation: R&D Department, Bial Industrial Farmacéutica S.A., Zamudio, Spain.
authors.forename: Begoña
authors.initials: B
authors.lastname: Madariaga-Goirigolzarri
authors.affiliation: R&D Department, Bial Industrial Farmacéutica S.A., Zamudio, Spain.
authors.forename: Juan Andrés
authors.initials: JA
authors.lastname: Asturias
authors.affiliation: Servicio de Alergología, IIS, Hospital Universitari La Fe, Valencia, Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Hernández-Fernandez de Rojas
mesh_terms: D000328:Adult; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D002457:Cell Extracts / Q000008:administration & dosage* / Q000009:adverse effects; D003233:Conjunctivitis, Allergic / Q000276:immunology / Q000628:therapy*; D040002:Dermatophagoides pteronyssinus / Q000276:immunology*; D003888:Desensitization, Immunologic; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D065631:Rhinitis, Allergic / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D039741:Antigens, Dermatophagoides; D002457:Cell Extracts
keywords: Dermatophagoides pteronyssinus; house dust mite; rhinoconjunctivitis; subcutaneous immunotherapy