title: Multimodal imaging with (18)F-FDG-PET/CT and (111)In-Octreotide SPECT in patients with metastatic medullary thyroid carcinoma.
abstract: OBJECTIVE
  The aim of our study was to determine the role of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) and indium-111 Octreotide single photon emission tomography ((111)In-Octreotide SPECT) in the evaluation of metastatic medullary thyroid carcinoma (MMTC).
  
  
  METHODS
  Twenty-five MMTC patients were retrospectively evaluated. All patients had undergone whole-body (18)F-FDG-PET/CT including 20 who had also undergone (111)In-Octreotide SPECT within a maximum interval of 6 weeks. Diagnostic contrast-enhanced computed tomography (CT) alone or as part of (18)F-FDG-PET/CT examination was performed in all patients.
  
  
  RESULTS
  Contrast-enhanced CT detected a total of 131 lesions including 79 enlarged lymph nodes and 14 bone lesions. (18)F-FDG-PET/CT visualized a total of 92 true positive lesions (SUVmax range 1.1-10.0, mean 4.0 ± 1.7) including 66 lymph nodes, 7 of which were not enlarged on CT, and 8 bone metastases. In the 20 patients studied with both techniques, a total of 64 and 46 true positive lesions were detected by (18)F-FDG-PET/CT and (111)In-Octreotide SPECT, respectively. In particular, (18)F-FDG uptake was found in 43 lymph nodes and in 7 bone metastases whereas (111)In-Octreotide uptake was detected in 27 lymph nodes and in 10 bone metastases.
  
  
  CONCLUSIONS
  In MMTC patients, (18)F-FDG-PET/CT provides a useful contribution mainly in evaluating lymph node involvement whereas (111)In-Octreotide SPECT can contribute to the detection and somatostatin receptor characterization especially of bone lesions.
authors.affiliation: Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Edificio 10, 80131, Naples, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: De Luca
authors.affiliation: Institute of Biostructures and Bioimages, National Research Council, Naples, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Fonti
authors.affiliation: Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Edificio 10, 80131, Naples, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Camera
authors.affiliation: Institute of Biostructures and Bioimages, National Research Council, Naples, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Salvatore
authors.affiliation: Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
authors.forename: Antongiulio
authors.initials: A
authors.lastname: Faggiano
authors.affiliation: Nuclear Medicine Department, Hospital S. Andrea, La Spezia, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ciarmiello
authors.affiliation: Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Edificio 10, 80131, Naples, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Segreto
authors.affiliation: Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.affiliation: IRCCS-SDN, Naples, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Salvatore
authors.affiliation: Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Edificio 10, 80131, Naples, Italy. delvecc@unina.it.|Institute of Biostructures and Bioimages, National Research Council, Naples, Italy. delvecc@unina.it.
authors.forename: Silvana
authors.initials: S
authors.lastname: Del Vecchio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018278:Carcinoma, Neuroendocrine / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009362:Neoplasm Metastasis; D015282:Octreotide / Q000031:analogs & derivatives*; D000072078:Positron Emission Tomography Computed Tomography; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D055815:Young Adult
chemical_list: C094279:indium-111-octreotide; D019788:Fluorodeoxyglucose F18; D015282:Octreotide
keywords: 111In-Octreotide SPECT; 18F-FDG-PET/CT; Contrast-enhanced CT; Medullary thyroid carcinoma; Multimodal imaging