title: The expanding repertoire of receptor activity modifying protein (RAMP) function.
abstract: Receptor activity modifying proteins (RAMPs) associate with G-protein-coupled receptors (GPCRs) at the plasma membrane and together bind a variety of peptide ligands, serving as a communication interface between the extracellular and intracellular environments. The collection of RAMP-interacting GPCRs continues to expand and now consists of GPCRs from families A, B and C, suggesting that RAMP activity is extremely prevalent. RAMP association with GPCRs can regulate GPCR function by altering ligand binding, receptor trafficking and desensitization, and downstream signaling pathways. Here, we elaborate on these RAMP-dependent mechanisms of GPCR regulation, which provide opportunities for pharmacological intervention.
authors.affiliation: a Department of Cell Biology & Physiology and.
authors.forename: Klara R
authors.initials: KR
authors.lastname: Klein
authors.affiliation: a Department of Cell Biology & Physiology and.
authors.forename: Brooke C
authors.initials: BC
authors.lastname: Matson
authors.affiliation: a Department of Cell Biology & Physiology and.|b Department of Genetics , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Caron
mesh_terms: D008024:Ligands; D010802:Phylogeny; D011485:Protein Binding; D058261:Receptor Activity-Modifying Proteins / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D058261:Receptor Activity-Modifying Proteins
keywords: CLR; G-protein; GPCR; desensitization; ligand; signaling; trafficking