title: Alkaloids with antioxidant activities from Aconitum handelianum.
abstract: A new C20-diterpenoid alkaloid handelidine (1) and twenty-seven known alkaloids (2-28) were isolated from the roots of Aconitum handelianum. Their structures were established on the basis of extensive spectroscopic analyses. The study indicated that denudatine-type C20-diterpenoid alkaloids with vicinal-triol system and benzyltetrahydroisoquinoline alkaloids exhibited significant antioxidant activities measured by three antioxidant test systems. The aconitine-type C19-diterpenoid alkaloids could serve as potential secondary antioxidants for their strong binding effects to metal ions.
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
authors.forename: Tian-Peng
authors.initials: TP
authors.lastname: Yin
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
authors.forename: Le
authors.initials: L
authors.lastname: Cai
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xing
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
authors.forename: Xue-Jiao
authors.initials: XJ
authors.lastname: Li
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
authors.forename: Rui-Feng
authors.initials: RF
authors.lastname: Mei
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
authors.forename: Zhong-Tao
authors.initials: ZT
authors.lastname: Ding
mesh_terms: D000157:Aconitine / Q000737:chemistry; D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C000613528:handelidine; C034767:denudatine; D000157:Aconitine
keywords: Aconitum handelianum; Ranunculaceae; antioxidant; diterpenoid alkaloid; handelidine