title: Tumor necrosis factor-α G-308A (rs1800629) polymorphism and aggressive periodontitis susceptibility: a meta-analysis of 16 case-control studies.
abstract: Association between tumor necrosis factor-α (TNF-α) G-308A (rs1800629) polymorphism and susceptibility to aggressive periodontitis (AgP) were inconsistent, hence we performed this meta-analysis to clarify the association between them using Comprehensive Meta-Analysis v2.2 software. 16 case-control studies were searched from the PubMed, Embase and CNKI databases up to February 2, 2015. The meta-analysis showed a significantly increased risk in A vs. G (OR = 1.23, 95%CI = 1.04-1.44), AA vs. GG (OR = 2.07, 95%CI = 1.11-3.87), and AA vs. AG+GG genetic models (OR = 2.09, 95%CI = 1.13-3.86); however, the non-significantly increased risk was shown in AG vs. GG (OR = 1.06, 95%CI = 0.85-1.32) and AA+AG vs. GG genetic models (OR = 1.06, 95%CI = 0.85-1.31). Cumulative analysis showed that the association changed from non-significant to significant with new studies accumulated and the CIs became more and more narrow, sensitivity analysis indicated results were statistically robust. Stratified analyses of confirmed of HWE, Asians, Caucasians, and population-based controls obtained results similar to that of overall analysis. There was no evidence of publication bias. In summary, current evidence demonstrates that TNF-a G-308A polymorphism might be associated with AgP susceptibility, especially in Asians and Caucasians.
authors.affiliation: Department of Nursing, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P.R. China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Wei
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China.
authors.forename: Yong-Ji
authors.initials: YJ
authors.lastname: Chen
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Vascular Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P.R. China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Cui
authors.affiliation: Department of Nursing, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P.R. China.
authors.forename: Ding-Wei
authors.initials: DW
authors.lastname: Hu
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China.|Department of Vascular Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P.R. China.
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Zeng
mesh_terms: D010520:Aggressive Periodontitis / Q000453:epidemiology* / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha