title: Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study.
abstract: BACKGROUND
  The C-reactive protein (CRP) and the tumor necrosis factor-alpha (TNF-α) are considered markers of inflammation and have been shown to predict the risk of incident cardiovascular events. However, few studies have undertaken a comprehensive examination of SNPs (single nucleotide polymorphisms) of the CRP and TNF-α genes; due to this, we will present a protocol study to evaluate the role of the CRP and TNF-α genes in Mexican individuals.
  
  
  METHODS
  we will perform a case-control study to explore the CRP and TNF-α genotype distribution as well as the serum influence of rs1800947, rs1130864, rs2794521 and rs1205 (polymorphisms of the CRP gene) and rs361525, rs1800629, rs1799724, rs1800630, rs1799964 (of the TNF-α gene) in Mexican individuals who present coronary artery disease.
  
  
  BACKGROUND
  a written informed consent will be obtained from all the participating subjects. An article detailing the results of the study will be submitted for publication in an international peer-reviewed journal, in accordance with STROBE criteria.
authors.affiliation: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco 86205, México. yazmin.hdez.diaz@gmail.com.
authors.forename: Yazmín
authors.initials: Y
authors.lastname: Hernández-Díaz
authors.affiliation: División Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco 86650, México. alfonso_tovillaz@yahoo.com.mx.
authors.forename: Carlos Alfonso
authors.initials: CA
authors.lastname: Tovilla-Zárate
authors.affiliation: División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco Villahermosa, Tabasco 86150, México. iselajuarazrojop@hotmail.com.
authors.forename: Isela
authors.initials: I
authors.lastname: Juárez-Rojop
authors.affiliation: Hospital General de Yajalón. Secretaría de Salud, Yajalón, Chiapas 29932, México. dralilialonar@yahoo.com.mx.
authors.forename: María Lilia
authors.initials: ML
authors.lastname: López-Narváez
authors.affiliation: División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco Villahermosa, Tabasco 86150, México. paco_cca@hotmail.com.
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Álvarez-Cámara
authors.affiliation: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco 86205, México. thelma.glez.castro@gmail.com.
authors.forename: Thelma Beatriz
authors.initials: TB
authors.lastname: González-Castro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000235:genetics*
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
keywords: CAD; CRP; Mexican population; TNF-α; association studies