title: Functional assessment and quality of life before and after pulmonary endoarterectomy.
abstract: OBJECTIVE
  The study investigates Quality of Life (QOL) and correlation with functional status of patients affected by Chronic Thromboembolic Pulmonary Hypertension who undergo Pulmonary Endoarterectomy.
  
  
  METHODS
  We investigated with an observational design (before surgery, three and twelve months afterwards) the hemodynamic data (NYHA class, mean pulmonary arterial pressure, cardiac output and pulmonary vascular resistance), the functional status (using the 6-Minute Walk Test) and the QOL, using three questionnaires: Medical Outcome Study Short Form-36 (SF-36), Minnesota Living with Heart Failure Questionnaire (MLHFQ), Saint George Respiratory Questionnaire (SGRQ). We report the results of forty-nine patients.
  
  
  RESULTS
  After surgery there was an improvement on functional and hemodynamic parameters and on QOL. The physical domain (PCS) of SF-36 was weakly but significantly associated with all functional parameters. There was no association between functional parameters and mental domain (MCS) of SF-36 or SGRQ. The improvement in 6-Minute Walk Distance was associated with an increase in MLHFQ.
  
  
  CONCLUSIONS
  Both QOL and submaximal exercise tolerance improve after surgery. However only the physical domains of SF-36 appear to be significantly associated to the functional data.
authors.forename: Lucia
authors.initials: L
authors.lastname: Petrucci
authors.forename: Ettore
authors.initials: E
authors.lastname: Carlisi
authors.forename: Susanna
authors.initials: S
authors.lastname: Ricotti
authors.forename: Simona
authors.initials: S
authors.lastname: Zanellato
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.forename: Andrea M
authors.initials: AM
authors.lastname: D'Armini
authors.forename: Salvatore
authors.initials: S
authors.lastname: Nicolardi
authors.forename: Marco
authors.initials: M
authors.lastname: Morsolini
authors.forename: Mario
authors.initials: M
authors.lastname: Viganò
authors.forename: Elena
authors.initials: E
authors.lastname: Dalla Toffola
mesh_terms: D004691:Endarterectomy; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000150:complications / Q000503:physiopathology* / Q000601:surgery*; D011788:Quality of Life; D011795:Surveys and Questionnaires