title: Bariatric Surgery and Liver Cancer in a Consortium of Academic Medical Centers.
abstract: Obesity is implicated as an important factor in the rising incidence of liver cancer in the USA. Bariatric surgery is increasingly used for treating morbid obesity and comorbidities. Using administrative data from UHC, a consortium of academic medical centers in the USA, we compared the prevalence of liver cancer among admissions with and without a history of bariatric surgery within a 3-year period. Admissions with a history of bariatric surgery had a 61 % lower prevalence of liver cancer compared to those without a history of bariatric surgery (prevalence ratio 0.39, 95 % confidence interval 0.35-0.44), and these inverse associations persisted within strata of sex, race, and ethnicity. This hospital administrative record-based analysis suggests that bariatric surgery could play a role in liver cancer prevention.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892-9774, USA. baiyu.yang@nih.gov.
authors.forename: Baiyu
authors.initials: B
authors.lastname: Yang
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892-9774, USA. yanghan@mail.nih.gov.
authors.forename: Hannah P
authors.initials: HP
authors.lastname: Yang
authors.affiliation: Division of Gynecologic Oncology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL, 32209, USA. kristy.kay.ward@gmail.com.
authors.forename: Kristy K
authors.initials: KK
authors.lastname: Ward
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892-9774, USA. vikrant.sahasrabuddhe@nih.gov.|Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, 20892-9783, USA. vikrant.sahasrabuddhe@nih.gov.
authors.forename: Vikrant V
authors.initials: VV
authors.lastname: Sahasrabuddhe
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892-9774, USA. mcglynnk@mail.nih.gov.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: McGlynn
mesh_terms: D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050110:Bariatric Surgery; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D015995:Prevalence; D065840:Protective Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Administrative records; Bariatric surgery; Diabetes; Liver cancer; Obesity