title: Techno-economic evaluation of a complete bioprocess for 2,3-butanediol production from renewable resources.
abstract: This study presents the techno-economic evaluation of 2,3-butanediol (BDO) production via fermentation using glycerol, sucrose and sugarcane molasses as carbon sources. Literature-cited experimental data were used to design the fermentation stage, whereas downstream separation of BDO was based on reactive extraction of BDO employing an aldehyde to convert BDO into an acetal that is immiscible with water. The selected downstream process can be used in all fermentations employed. Sensitivity analysis was carried out targeting the estimation of the minimum selling price (MSP) of BDO at different plant capacities and raw material purchase costs. In all cases, the MSP of BDO is higher than 1 $/kg that is considered as the target in order to characterize a fermentation product as platform chemical. The complex nutrient supplements, the raw material market price and the fermentation efficiency were identified as the major reasons for the relatively high MSP observed.
authors.affiliation: Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.
authors.forename: Apostolis A
authors.initials: AA
authors.lastname: Koutinas
authors.affiliation: Biochemistry Department, Chemistry Institute, Federal University of Rio de Janeiro, Cidade Universitária, Centro de Tecnologia, Bloco A, Lab 549, Rio de Janeiro 21941-909, RJ, Brazil.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Yepez
authors.affiliation: Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kopsahelis
authors.affiliation: Biochemistry Department, Chemistry Institute, Federal University of Rio de Janeiro, Cidade Universitária, Centro de Tecnologia, Bloco A, Lab 549, Rio de Janeiro 21941-909, RJ, Brazil.
authors.forename: Denise M G
authors.initials: DMG
authors.lastname: Freire
authors.affiliation: Biotechnology Division, Research and Development Center, PETROBRAS, Av. Horácio Macedo, 950. Ilha do Fundão, Rio de Janeiro 21941-915, Brazil.
authors.forename: Aline Machado
authors.initials: AM
authors.lastname: de Castro
authors.affiliation: Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.
authors.forename: Seraphim
authors.initials: S
authors.lastname: Papanikolaou
authors.affiliation: Department of Chemical Engineering, University of Patras, Rio, 26504 Patras, Greece. Electronic address: i.kookos@chemeng.upatras.gr.
authors.forename: Ioannis K
authors.initials: IK
authors.lastname: Kookos
mesh_terms: D061249:Batch Cell Culture Techniques; D019149:Bioreactors; D002072:Butylene Glycols / Q000737:chemistry / Q000378:metabolism*; D002244:Carbon; D003247:Conservation of Natural Resources / Q000379:methods*; D003362:Cost-Benefit Analysis; D005285:Fermentation; D005990:Glycerol; D006863:Hydrogen-Ion Concentration; D007218:Industrial Microbiology / Q000379:methods; D008965:Molasses / Q000032:analysis*; D031786:Saccharum / Q000737:chemistry*; D013395:Sucrose
chemical_list: D002072:Butylene Glycols; C026978:2,3-butylene glycol; D013395:Sucrose; D002244:Carbon; D005990:Glycerol
keywords: 2,3-Butanediol; Bioprocess design; Fermentation; Minimum selling price; Sensitivity analysis