title: A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated Lactobacillus LB.
abstract: Experimental in vitro and in vivo studies support the hypothesis that heat-treated, lyophilized Lactobacillus acidophilus LB cells and concentrated, neutralized spent culture medium conserve the variety of pharmacological, antimicrobial activities of the live probiotic strain against several infectious agents involved in well-established acute and persistent watery diarrhoea and gastritis. Heat-treated cells and heat-stable secreted molecules trigger multiple strain-specific activities explaining the therapeutic efficacy of L. acidophilus LB. This review discusses the current body of knowledge on the antimicrobial mechanisms of action exerted by L. acidophilus LB demonstrated in in vitro and in vivo experimental studies, and the evidence for the therapeutic efficacy of this anti-infectious biotherapeutic agent proved in randomized clinical trials for the treatment of acute and persistent watery diarrhoea associated with several intestinal infectious diseases in humans.
authors.affiliation: CNRS UMR 8076 BioCIS. LabEx LERMIT - Laboratory of Excellence in Research on Medication and Innovative Therapeutic. Faculty of Pharmacy, University Paris-Sud, F-92296 Châtenay-Malabry, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Liévin-Le Moal
keywords: Lactobacillus; Lactobacillus acidophilus LB; Salmonella; antibacterial; biotherapeutic; diarrhoea; enterovirulent Escherichia coli; gastroenteritis; pharmabiotic; probiotic