title: Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia.
abstract: Here we studied the cytoprotective effect of lithium chloride and sodium valproate in the in vivo model of neonatal cerebral ischemia/hypoxia and analyzed the influence of these substances on the death of the major neurovascular unit components in experimental ischemia in vitro. Lithium chloride and sodium valproate effectively prevented death of neurons, astrocytes, and endothelial cells in the oxygen-glucose deprivation. This treatment protected the brain of newborn rats from ischemia/hypoxia injury. The results suggest that lithium and sodium valproate can be used for the treatment of neurodegenerative pathologies associated with hypoxia and ischemia in newborns.
authors.affiliation: A. N. Belozersky Institute of Physical and Chemical Biology, Moscow, Russia.
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.affiliation: A. N. Belozersky Institute of Physical and Chemical Biology, Moscow, Russia.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Plotnikov
authors.affiliation: Faculty of Bioengineering and Bioinformatics, Moscow, Russia.|V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Babenko
authors.affiliation: Faculty of Bioengineering and Bioinformatics, Moscow, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Savchenko
authors.affiliation: International Laser Research Centre, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: L D
authors.initials: LD
authors.lastname: Zorova
authors.affiliation: A. N. Belozersky Institute of Physical and Chemical Biology, Moscow, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Pevzner
authors.affiliation: Faculty of Physics, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Gulyaev
authors.affiliation: Faculty of Physics, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Pirogov
authors.affiliation: V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
authors.affiliation: A. N. Belozersky Institute of Physical and Chemical Biology, Moscow, Russia. zorov@genebee.msu.ru.
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001930:Brain Injuries / Q000188:drug therapy*; D000860:Hypoxia / Q000188:drug therapy*; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy*; D018021:Lithium Chloride / Q000627:therapeutic use*; D051381:Rats; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D014635:Valproic Acid; D018021:Lithium Chloride
keywords: cytoprotection; lithium; neonatal ischemia; neurovascular unit; valproate