title: Recent Scientific Advances Towards the Development of Tendon Healing Strategies.
abstract: There exists a range of surgical and non-surgical approaches to the treatment of both acute and chronic tendon injuries. Despite surgical advances in the management of acute tears and increasing treatment options for tendinopathies, strategies frequently are unsuccessful, due to impaired mechanical properties of the treated tendon and/or a deficiency in progenitor cell activities. Hence, there is an urgent need for effective therapeutic strategies to augment intrinsic and/or surgical repair. Such approaches can benefit both tendinopathies and tendon tears which, due to their severity, appear to be irreversible or irreparable. Biologic therapies include the utilization of scaffolds as well as gene, growth factor, and cell delivery. These treatment modalities aim to provide mechanical durability or augment the biologic healing potential of the repaired tissue. Here, we review the emerging concepts and scientific evidence which provide a rationale for tissue engineering and regeneration strategies as well as discuss the clinical translation of recent innovations.
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
authors.forename: Eli T
authors.initials: ET
authors.lastname: Sayegh
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, IL 60612.
authors.forename: John D
authors.initials: JD
authors.lastname: Sandy
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
authors.forename: Mandeep S
authors.initials: MS
authors.lastname: Virk
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Romeo
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Wysocki
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
authors.forename: Jorge O
authors.initials: JO
authors.lastname: Galante
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
authors.forename: Katie J
authors.initials: KJ
authors.lastname: Trella
authors.affiliation: Department of Rheumatology/Internal Medicine, Rush University Medical Center, Chicago, IL 60612.
authors.forename: Anna
authors.initials: A
authors.lastname: Plaas
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Wang
keywords: Tendinopathy; biomechanics; extracellular matrix; healing; therapeutics