title: A grain of salt on kidney dendritic cell function in allograft rejection.
abstract: Acute kidney graft allorejection affects primarily the renal cortex. The present study by Chessa et al. offers an explanation for this phenomenon. The authors employ microarray-based gene expression analysis to provide evidence that the hyperosmolarity of the renal medulla induces a transcriptional fingerprint associated with anti-inflammatory functionality in medullary dendritic cells, which may attenuate local alloreactivity. This novel immunoregulatory mechanism hints at a new opportunity to prevent allorejection.
authors.affiliation: Institute of Experimental Immunology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jobin
authors.affiliation: Institute of Experimental Immunology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Heuser
authors.affiliation: Institute of Experimental Immunology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany. Electronic address: ckurts@web.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Kurts
mesh_terms: D064591:Allografts; D003713:Dendritic Cells / Q000378:metabolism; D006084:Graft Rejection; D006801:Humans; D007668:Kidney; D016030:Kidney Transplantation; D017673:Sodium Chloride, Dietary / Q000378:metabolism
chemical_list: D017673:Sodium Chloride, Dietary