title: Fecal Calprotectin as an Activity Marker of Inflammatory Bowel Disease in Children.
abstract: BACKGROUND
  Children constitute 20% of patients with inflammatory bowel diseases (IBD). Still there is a search for a perfect marker for this group of patients which would help in the diagnosis of the disease, in determinating its activity and in monitoring the treatment.
  
  
  OBJECTIVE
  Evaluate the usefulness of the application of calprotectin measurement in stool samples from children with IBD, as a marker of the severity of inflammation.
  
  
  METHODS
  We analysed 156 patients: 58 with ulcerative colitis (UC), 67 with Crohn's disease (CD), and 31 from the control group. In all patients the concentration of calprotectin in the sample of feces, markers of inflammation and hemoglobin were measured.
  
  
  RESULTS
  Concentration of calprotectin in feces of patients with IBD was above the normal range in all patients with moderate and severe disease and in the majority with mild disease or in remission, but it was normal in all patients from the control group.
  
  
  CONCLUSIONS
  Elevated concentration of fecal calprotectin (FC) was observed in the majority of patients with IBD, but in none from the control group. The number of patients with elevated FC concentration increased together with the disease activity. FC concentration was higher in patients with severe and moderate disease activity. FC concentration in patients with IBD was associated with the increase of inflammatory markers and decreased haemoglobin. Percentage of laboratory abnormalities in children with Crohn's disease and perianal changes was higher. FC concentration can be a noninvasive marker of disease activity in IBD.
authors.affiliation: 2nd Department and Clinic of Paediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Krzesiek
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000378:metabolism* / Q000473:pathology; D003424:Crohn Disease / Q000378:metabolism* / Q000473:pathology; D005243:Feces / Q000737:chemistry*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D039841:Leukocyte L1 Antigen Complex