title: Therapy for kidney fibrosis: is the Src kinase a potential target?
abstract: Chronic kidney disease (CKD) is a public health challenge worldwide. As CKD is associated with high rates of morbidity and mortality, identification of novel targets for effective therapy is urgently needed. Yan et al. provide evidence that the Src kinase plays a critical role in the pathogenesis of CKD by integrating multiple fibrogenic signal inputs. Therefore, targeted inhibition of Src kinase may hold promise as a new strategy in the fight against CKD.
authors.affiliation: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: liuy@upmc.edu.
authors.forename: Youhua
authors.initials: Y
authors.lastname: Liu
mesh_terms: D006801:Humans; D051436:Renal Insufficiency, Chronic; D019061:src-Family Kinases
chemical_list: D019061:src-Family Kinases