title: [RESEARCH PROGRESS OF microRNA IN INTERVERTEBRAL DISC DEGENERATION].
abstract: OBJECTIVE
  To comprehensively analyze the relationship between microRNAs and intervertebral disc degeneration at home and abroad.
  
  
  METHODS
  The literature about the relationship between microRNAs and intervertebral disc degeneration was reviewed and analyzed.
  
  
  RESULTS
  MicroRNA can lead to intervertebral disc degeneration by regulating the gene expression, thus influencing the cell's apoptosis and proliferation, increasing of the production of inflammatory mediator and protease, which play important roles in intervertebral disc degeneration.
  
  
  CONCLUSIONS
  MicroRNA is a research focus in the field of intervertebral disc degeneration. Further research of the relationship between microRNAs and intervertebral disc degeneration will help to identify the pathogenesis of intervertebral disc degeneration and furnish the new ideal for the diagnosis and treatment of intervertebral disc degeneration.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Cui
authors.forename: Guixin
authors.initials: G
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Tan
authors.forename: Lijun
authors.initials: L
authors.lastname: Li
mesh_terms: D017209:Apoptosis / Q000235:genetics; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D044127:Epigenesis, Genetic; D015870:Gene Expression; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism* / Q000473:pathology; D055959:Intervertebral Disc Degeneration / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism
chemical_list: D035683:MicroRNAs