title: Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles.
abstract: A physiologically based pharmacokinetic model was developed for accurately characterizing and predicting the in vivo fate of long-circulating inorganic nanoparticles (NPs). This model is built based on direct visualization of NP disposition details at the organ and cellular level. It was validated with multiple data sets, indicating robust inter-route and interspecies predictive capability. We suggest that the biodistribution of long-circulating inorganic NPs is determined by the uptake and release of NPs by phagocytic cells in target organs.
authors.affiliation: Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute , Woolloongabba, QLD 4102, Australia.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Liang
authors.affiliation: Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute , Woolloongabba, QLD 4102, Australia.
authors.forename: Haolu
authors.initials: H
authors.lastname: Wang
authors.affiliation: Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute , Woolloongabba, QLD 4102, Australia.
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Grice
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , St Lucia, QLD 4067, Australia.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute , Woolloongabba, QLD 4102, Australia.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , St Lucia, QLD 4067, Australia.
authors.forename: Zhi Ping
authors.initials: ZP
authors.lastname: Xu
authors.affiliation: School of Pharmacy and Medical Sciences, University of South Australia , Adelaide, SA 5001, Australia.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Roberts
mesh_terms: D000818:Animals; D007287:Inorganic Chemicals / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D051379:Mice; D008956:Models, Chemical; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D010599:Pharmacokinetics; D045663:Quantum Dots / Q000737:chemistry*
chemical_list: D007287:Inorganic Chemicals
keywords: Physiologically-based pharmacokinetic model; biodistribution; inorganic nanoparticles; long-circulating