title: Ultrahigh (19)F Loaded Cu1.75S Nanoprobes for Simultaneous (19)F Magnetic Resonance Imaging and Photothermal Therapy.
abstract: (19)F magnetic resonance imaging (MRI) is a powerful noninvasive, sensitive, and accurate molecular imaging technique for early diagnosis of diseases. The major challenge of (19)F MRI is signal attenuation caused by the reduced solubility of probes with increased number of fluorine atoms and the restriction of molecular mobility. Herein, we present a versatile one-pot strategy for the fabrication of a multifunctional nanoprobe with high (19)F loading (∼2.0 × 10(8 19)F atoms per Cu1.75S nanoparticle). Due to the high (19)F loading and good molecular mobility that results from the small particle size (20.8 ± 2.0 nm) and ultrathin polymer coating, this nanoprobe demonstrates ultrahigh (19)F MRI signal. In vivo tests show that this multifunctional nanoprobe is suitable for (19)F MRI and photothermal therapy. This versatile fabrication strategy has also been readily extended to other single-particle nanoprobes for ablation and sensitive multimodal imaging.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Chen
authors.affiliation: Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University , Xiamen, Fujian 361005, People's Republic of China.
authors.forename: Manli
authors.initials: M
authors.lastname: Song
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
authors.forename: Gaofei
authors.initials: G
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
authors.forename: Suying
authors.initials: S
authors.lastname: Xu
authors.affiliation: Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University , Xiamen, Fujian 361005, People's Republic of China.
authors.forename: Zhide
authors.initials: Z
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Li
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
authors.forename: Jiabin
authors.initials: J
authors.lastname: Cui
authors.affiliation: Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University , Xiamen, Fujian 361005, People's Republic of China.
authors.forename: Xianzhong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, People's Republic of China.
authors.forename: Leyu
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000008:administration & dosage; D003300:Copper / Q000737:chemistry*; D005260:Female; D005462:Fluorine Radioisotopes / Q000008:administration & dosage; D066235:Fluorine-19 Magnetic Resonance Imaging / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D007279:Injections, Subcutaneous; D008321:Mammary Glands, Animal; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010789:Phototherapy / Q000379:methods*
chemical_list: D003287:Contrast Media; D005462:Fluorine Radioisotopes; D003300:Copper; C017846:cupric sulfide
keywords: 19F MRI; copper sulfide nanoparticle; multifunctional nanoprobes; photothermal imaging and therapy