title: Impacts of laparoscopic hysterectomy on functions of coagulation and fibrinolysis system.
abstract: The main objective of the study is to compare the impacts of laparoscopic hysterectomy and total abdominal hysterectomy on the functions of coagulation and fibrinolysis system. Seventy-five patients who had undergone hysterectomy were randomly divided into laparoscopic hysterectomy group (n = 38) and total abdominal hysterectomy group (n = 37). The prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen, D-dimer, von Willebrand factor, α-granule membrane protein-140, thrombin-activated fibrinolysis inhibitor (TAFI) and platelet count were detected at preoperative 24 h (N0), postoperative 24 h (N1) and postoperative 48 h (N2). Compared with N0, values of PT, APTT and TT were significantly decreased at N1 in both groups, whereas von Willebrand factor, platelet count and α-granule membrane protein-140 levels at N1 were significantly increased (P < 0.05). There was no significant difference between N0 and N2 (P > 0.05). Compared with N0, fibrinogen, D-dimer and TAFI levels in both groups were significantly higher at N1 (P < 0.05), and there was no significant difference between N0 and N2 (P > 0.05). The intergroup comparison showed no significant difference of above indexes between two groups (P > 0.05). The univariate analysis showed that TAFI was negatively correlated with TT (r = -0.365, P < 0.01), APTT (r = -0.183, P < 0.05) and PT (r = -0.121, P < 0.05), whereas not correlated with other indicators. Laparoscopic hysterectomy may increase the risk of postoperative venous thrombosis.
authors.affiliation: aDepartment of Gynecology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'anbDepartment of Gynecology, Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Honghui
authors.initials: H
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.forename: Chunjie
authors.initials: C
authors.lastname: Hu
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Gao
authors.forename: Yumei
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yang
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D025901:Carboxypeptidase B2 / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects / Q000379:methods*; D010535:Laparoscopy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D011517:Prothrombin Time; D012189:Retrospective Studies; D012306:Risk; D013918:Thrombin Time; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D019007:P-Selectin; C036309:fibrin fragment D; D014841:von Willebrand Factor; D005340:Fibrinogen; D025901:Carboxypeptidase B2