title: [THROMBOANGIITIS OBLITERANS (BUERGER'S DISEASE)].
abstract: To day there appears to be a consensus to recognize thromboangiftis obliterans (Buerger's disease) as a distinct clinical and pathological entity, characterized by an inflammatory occlusive vasculitis of the small and medium-sized arteries and veins that affects young adult smokers. The strong link with smoking is one of the unique features of thromboangiitis obliterans. Once the disease has became established stepping smoking is the only effective way to prevent evolution of the disease and to reduce the risk of major amputations. Ischaemia of the lower and upper limbs and superficial thrombophlabitis are the essential features of the clinical presentation. However the diagnosis of thromboangiitis is rendered difficult by the lack of specific clinical, radiological, biological and histapathological features. Thus the diagnosis is funded on a probabilistic approach. Discontinuation of tobacco use and to day cannabis are the cornerstone of therapeutic management of patients with thromboangiitis. In patients with ischaemic lesions local care is the other main component of therapeutic management, infusion of iloprost had demonstrated some efficacy.
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Fiessinger
authors.forename: Michael
authors.initials: M
authors.lastname: Frank
mesh_terms: D000671:Amputation, Surgical; D005121:Extremities / Q000098:blood supply; D006801:Humans; D007511:Ischemia / Q000209:etiology; D012907:Smoking / Q000009:adverse effects*; D016540:Smoking Cessation; D013919:Thromboangiitis Obliterans / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*