title: Results of a comparative analysis of magnetic resonance imaging-targeted versus three-dimensional transrectal ultrasound prostate biopsies: Size does matter.
abstract: OBJECTIVE
  The aim of this study was to compare the detection rate of clinically significant disease in magnetic resonance imaging (MRI)-targeted biopsies versus three-dimensional transrectal ultrasound (3D TRUS)-guided biopsies according to prostate size.
  
  
  METHODS
  The study compared 120 consecutive biopsy-naïve men who underwent 3D TRUS-guided systematic biopsy to 120 consecutive men who underwent MRI-targeted biopsy. Stratifications based on tertiles were used for assessing interactions between prostate volume and rates of detection of significant cancer.
  
  
  RESULTS
  Older age, higher prostate-specific antigen level, lower prostate volume, increased number of cores and MRI-targeted biopsy were independent predictors of prostate cancer detection in the entire cohort on logistic regression. Clinically significant cancer detection rates were significantly higher in the MRI-targeted group than in the 3D TRUS-guided biopsy group (48.7% vs 29.4%, p = 0.002). When stratified according to prostate volume, these rates were significantly higher only in the third tertile group (volume > 50 cm(3)) for MRI-targeted biopsy compared to 3D TRUS-guided biopsy (56% vs 22%, p = 0.003).
  
  
  CONCLUSIONS
  MRI-targeted biopsies increased the detection rate of clinically significant prostate cancer only in patients with enlarged prostates compared to the 3D TRUS.
authors.affiliation: a Department of Urology , Jules Bordet Institute, Université Libre de Bruxelles , Brussels , Belgium ;
authors.forename: Alexandre
authors.initials: A
authors.lastname: Peltier
authors.affiliation: a Department of Urology , Jules Bordet Institute, Université Libre de Bruxelles , Brussels , Belgium ;
authors.forename: Fouad
authors.initials: F
authors.lastname: Aoun
authors.affiliation: a Department of Urology , Jules Bordet Institute, Université Libre de Bruxelles , Brussels , Belgium ;
authors.forename: Simone
authors.initials: S
authors.lastname: Albisinni
authors.affiliation: a Department of Urology , Jules Bordet Institute, Université Libre de Bruxelles , Brussels , Belgium ;
authors.forename: Quentin
authors.initials: Q
authors.lastname: Marcelis
authors.affiliation: a Department of Urology , Jules Bordet Institute, Université Libre de Bruxelles , Brussels , Belgium ;
authors.forename: Dam
authors.initials: D
authors.lastname: Ledinh
authors.affiliation: b Department of Statistics , Jules Bordet Institute, Université Libre de Bruxelles , Brussels , Belgium ;
authors.forename: Marianne
authors.initials: M
authors.lastname: Paesmans
authors.affiliation: c Department of Radiology , Jules Bordet Institute, Université Libre de Bruxelles , Brussels , Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Lemort
authors.affiliation: a Department of Urology , Jules Bordet Institute, Université Libre de Bruxelles , Brussels , Belgium ;
authors.forename: Roland
authors.initials: R
authors.lastname: van Velthoven
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods; D021621:Imaging, Three-Dimensional; D053783:Magnetic Resonance Imaging, Interventional; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional
keywords: Biopsy; diagnosis; multiparametric magnetic resonance imaging; prostate cancer; prostate volume