title: Sex Hormone-Binding Globulin in Children and Adolescents.
abstract: Sex hormone-binding globulin (SHBG) is a circulating glycoprotein that transports testosterone and other steroids in the blood. Interest in SHBG has escalated in recent years because of its inverse association with obesity and insulin resistance, and because many studies have linked lower circulating levels of SHBG to metabolic syndrome, type 2 diabetes, nonalcoholic fatty liver disease, polycystic ovary syndrome, and early puberty. The purpose of this review is to summarize molecular, clinical, endocrine, and epidemiological findings to illustrate how measurement of plasma SHBG may be useful in clinical medicine in children.
authors.forename: Banu
authors.initials: B
authors.lastname: Aydın
authors.affiliation: University of Louisville Faculty of Medicine, Division of Endocrinology, Metabolism and Diabetes, Kentucky, USA Phone: +1 502 852 52 37 E-mail: sjwint01@louisville.edu.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Winters
mesh_terms: D000293:Adolescent; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology* / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology* / Q000378:metabolism; D011379:Prognosis; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*
chemical_list: D012738:Sex Hormone-Binding Globulin