title: Adjuvant treatment for older women with invasive breast cancer.
abstract: Older women experience a large share of breast cancer incidence and death. With the projected rise in the number of older cancer patients, adjuvant chemo-, radiation and endocrine therapy management will become a key component of breast cancer treatment in older women. Many factors influence adjuvant treatment decisions including patient preferences, life expectancy and tumor biology. Geriatric assessment predicts important outcomes, identifies key deficits, and can aid in the decision making process. This review utilizes clinical vignettes to illustrate core principles in adjuvant management of breast cancer in older women and suggests an approach incorporating life expectancy and geriatric assessment.
authors.affiliation: Hematology & Oncology Division, University of North Carolina, Chapel Hill, NC 27599, USA.|Division of Geriatric Medicine & Center for Aging & Health, University of North Carolina, Chapel Hill, NC 27599, USA.|Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.
authors.forename: Trevor A
authors.initials: TA
authors.lastname: Jolly
authors.affiliation: Hematology & Oncology Division, University of North Carolina, Chapel Hill, NC 27599, USA.|Division of Geriatric Medicine & Center for Aging & Health, University of North Carolina, Chapel Hill, NC 27599, USA.|Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.
authors.forename: Grant R
authors.initials: GR
authors.lastname: Williams
authors.affiliation: Department of Medicine/School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Sita
authors.initials: S
authors.lastname: Bushan
authors.affiliation: Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Mackenzi
authors.initials: M
authors.lastname: Pergolotti
authors.affiliation: Hematology & Oncology Division, University of North Carolina, Chapel Hill, NC 27599, USA.|Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.
authors.forename: Kirsten A
authors.initials: KA
authors.lastname: Nyrop
authors.affiliation: Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Ellen L
authors.initials: EL
authors.lastname: Jones
authors.affiliation: Hematology & Oncology Division, University of North Carolina, Chapel Hill, NC 27599, USA.|Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.
authors.forename: Hyman B
authors.initials: HB
authors.lastname: Muss
mesh_terms: D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D003657:Decision Making; D019468:Disease Management; D005260:Female; D015577:Geriatric Assessment / Q000706:statistics & numerical data*; D006801:Humans; D008017:Life Expectancy; D008875:Middle Aged; D020360:Neoadjuvant Therapy
chemical_list: D000970:Antineoplastic Agents
keywords: adjuvant chemotherapy; breast cancer; elderly; endocrine therapy; geriatric assessment; geriatric oncology; radiation