title: Microbiota Control of Malaria Transmission.
abstract: Stable mutualistic interactions between multicellular organisms and microbes are an evolutionarily conserved process with a major impact on host physiology and fitness. Humans establish such interactions with a consortium of microorganisms known as the microbiota. Despite the mutualistic nature of these interactions, some bacterial components of the human microbiota express immunogenic glycans that elicit glycan-specific antibody (Ab) responses. The ensuing circulating Abs are protective against infections by pathogens that express those glycans, as demonstrated for Plasmodium, the causative agent of malaria. Presumably, a similar protective Ab response acts against other vector-borne diseases.
authors.affiliation: Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, 2780-156, Oeiras, Portugal. Electronic address: mpsoares@igc.gulbenkian.pt.
authors.forename: Miguel P
authors.initials: MP
authors.lastname: Soares
authors.affiliation: Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, 2780-156, Oeiras, Portugal; Current address: Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland. Electronic address: bahtiyar_yilmaz@outlook.com.
authors.forename: Bahtiyar
authors.initials: B
authors.lastname: Yilmaz
mesh_terms: D000906:Antibodies / Q000276:immunology; D005075:Biological Evolution; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007422:Intestines / Q000382:microbiology; D016778:Malaria, Falciparum / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control / Q000635:transmission*; D064307:Microbiota / Q000276:immunology / Q000502:physiology*; D010963:Plasmodium falciparum / Q000502:physiology; D011134:Polysaccharides / Q000276:immunology; D016052:Protozoan Vaccines / Q000276:immunology
chemical_list: D000906:Antibodies; D011134:Polysaccharides; D016052:Protozoan Vaccines