title: Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis.
abstract: Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.
authors.affiliation: University of Bordeaux, ARNA laboratory , F-33000 Bordeaux, France.|INSERM, U869, ARNA laboratory , F-33000 Bordeaux, France.
authors.forename: Khalid
authors.initials: K
authors.lastname: Oumzil
authors.affiliation: University of Bordeaux, ARNA laboratory , F-33000 Bordeaux, France.|INSERM, U869, ARNA laboratory , F-33000 Bordeaux, France.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Ramin
authors.affiliation: CRMSB Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, CNRS, University of Bordeaux , F-33076 Bordeaux, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Lorenzato
authors.affiliation: CRMSB Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, CNRS, University of Bordeaux , F-33076 Bordeaux, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Hémadou
authors.affiliation: CRMSB Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, CNRS, University of Bordeaux , F-33076 Bordeaux, France.
authors.forename: Jeanny
authors.initials: J
authors.lastname: Laroche
authors.affiliation: CRMSB Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, CNRS, University of Bordeaux , F-33076 Bordeaux, France.
authors.forename: Marie Josée
authors.initials: MJ
authors.lastname: Jacobin-Valat
authors.affiliation: Institut de Chimie de la Matière Condensée de Bordeaux, ICMCB UPR CNRS 9048, University of Bordeaux , F-33608 Pessac, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Mornet
authors.affiliation: University of Bordeaux, ARNA laboratory , F-33000 Bordeaux, France.|INSERM, U869, ARNA laboratory , F-33000 Bordeaux, France.
authors.forename: Claude-Eric
authors.initials: CE
authors.lastname: Roy
authors.affiliation: University of Bordeaux, ARNA laboratory , F-33000 Bordeaux, France.|INSERM, U869, ARNA laboratory , F-33000 Bordeaux, France.
authors.forename: Tina
authors.initials: T
authors.lastname: Kauss
authors.affiliation: University of Bordeaux, ARNA laboratory , F-33000 Bordeaux, France.|INSERM, U869, ARNA laboratory , F-33000 Bordeaux, France.
authors.forename: Karen
authors.initials: K
authors.lastname: Gaudin
authors.affiliation: CRMSB Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, CNRS, University of Bordeaux , F-33076 Bordeaux, France.
authors.forename: Gisèle
authors.initials: G
authors.lastname: Clofent-Sanchez
authors.affiliation: University of Bordeaux, ARNA laboratory , F-33000 Bordeaux, France.|INSERM, U869, ARNA laboratory , F-33000 Bordeaux, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Barthélémy
mesh_terms: D050197:Atherosclerosis / Q000628:therapy*; D011464:Epoprostenol / Q000008:administration & dosage / Q000627:therapeutic use*; D008055:Lipids / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053758:Nanoparticles
chemical_list: D008055:Lipids; D011464:Epoprostenol