title: Synthesis, characterization and antimicrobial activities of novel silver(I) complexes with coumarin substituted N-heterocyclic carbene ligands.
abstract: Eight new coumarin substituted silver(I) N-heterocyclic carbene (NHC) complexes were synthesized by the interaction of the corresponding imidazolium or benzimidazolium chlorides and Ag2O in dichloromethane at room temperature. Structures of these complexes were established on the basis of elemental analysis, (1)H NMR, (13)C NMR, IR and mass spectroscopic techniques. The antimicrobial activities of carbene precursors and silver NHC complexes were tested against standard strains: Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and the fungi Candida albicans and Candida tropicalis. Results showed that all the compounds inhibited the growth of the all bacteria and fungi strains and some complexes performed good activities against different microorganisms. Among all the compounds, the most lipophilic complex bis[1-(4-methylene-6,8-dimethyl-2H-chromen-2-one)-3-(naphthalene-2-ylmethyl)benzimidazol-2-ylidene]silver(I) dichloro argentate (5e) was found out as the most active one.
authors.affiliation: Inonu University, Faculty of Science, Department of Chemistry, 44280 Malatya, Turkey. Electronic address: mert.karatas@inonu.edu.tr.
authors.forename: Mert Olgun
authors.initials: MO
authors.lastname: Karataş
authors.affiliation: Ege University Faculty of Science, Department of Chemistry, 35100 Izmir, Turkey.
authors.forename: Begüm
authors.initials: B
authors.lastname: Olgundeniz
authors.affiliation: Inonu University, Faculty of Medicine, Department of Microbiology, 44280 Malatya, Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Günal
authors.affiliation: Inonu University, Faculty of Science, Department of Chemistry, 44280 Malatya, Turkey.
authors.forename: İlknur
authors.initials: İ
authors.lastname: Özdemir
authors.affiliation: Inonu University, Faculty of Science, Department of Chemistry, 44280 Malatya, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Alıcı
authors.affiliation: Ege University Faculty of Science, Department of Chemistry, 35100 Izmir, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Çetinkaya
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D041022:Candida tropicalis / Q000187:drug effects / Q000254:growth & development; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003374:Coumarins; D006571:Heterocyclic Compounds; D008024:Ligands; D009942:Organometallic Compounds; C030011:carbene; D012834:Silver; C030123:coumarin; D008697:Methane
keywords: Antibacterial; Antifungal; Carbene; Coumarin; Silver