title: The NLRP1-IL18 Connection: A Stab in the Back of Obesity-Induced Inflammation.
abstract: IL-18 has been reported to counteract obesity and metabolic syndrome, though the underlying mechanisms remain unclear. In this issue, Masters and colleagues describe how NLRP1 inflammasome induces IL-18 production in fat, solving not only an important biological mechanism, but also opening the door for therapeutic approaches (Murphy et al., 2016).
authors.affiliation: Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525GA Nijmegen, the Netherlands. Electronic address: mihai.netea@radboudumc.nl.
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
authors.affiliation: Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525GA Nijmegen, the Netherlands. Electronic address: leo.joosten@radboudumc.nl.
authors.forename: Leo A B
authors.initials: LA
authors.lastname: Joosten
mesh_terms: D006801:Humans; D058847:Inflammasomes / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism; D020382:Interleukin-18 / Q000378:metabolism*; D024821:Metabolic Syndrome; D009765:Obesity
chemical_list: D058847:Inflammasomes; D020382:Interleukin-18