title: [Association between genotype and allele frequencies of CYP2A6*12 and rs16969968 in CHRNA5 variants with smoking and body mass index in young subjects from Northeast Mexico].
abstract: BACKGROUND
  Several studies have reported that variants rs16969968 G>A of the CHRNA5 gene and CYP2A6*12 of the CYP2A6 gene are associated with smoking and smoking refusal, respectively. In addition, some studies report that a higher cigarette consumption is associated with low body mass index (BMI).
  
  
  OBJECTIVE
  To analyze the allele and genotypic frequencies of these variants and their impact on smoking and BMI.
  
  
  METHODS
  A blood sample was obtained and a survey about smoking habits was answered by 319 university students aged 18 to 35 years (127 women, 171 smokers), living in Northeastern Mexico. Genetic variants were studied by polymerase chain reaction/restriction fragment length polymorphism and their frequencies were associated with smoking and BMI.
  
  
  RESULTS
  No associations were found between the analyzed variants and smoking in the study groups. However, there was an association among non-smoking subjects between the A allele of rs16969968 and high a BMI (p < 0.01).
  
  
  CONCLUSIONS
  This last variant may be involved in food-addiction disorders.
authors.forename: Gissela
authors.initials: G
authors.lastname: Borrego-Soto
authors.forename: Antonio
authors.initials: A
authors.lastname: Costilla-Esquivel
authors.forename: Gerardo Raymundo
authors.initials: GR
authors.lastname: Padilla-Rivas
authors.forename: Paulina Janeth
authors.initials: PJ
authors.lastname: Cázares-Samaniego
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Posadas-Valay
authors.forename: José Gerardo
authors.initials: JG
authors.lastname: Velasco-Castañón
authors.forename: Roberto
authors.initials: R
authors.lastname: Mercado-Longoria
authors.forename: Rocío
authors.initials: R
authors.lastname: Ortiz-López
authors.forename: Augusto
authors.initials: A
authors.lastname: Rojas-Martínez
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D065637:Cytochrome P-450 CYP2A6 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009538:Nicotine / Q000378:metabolism; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics; D011978:Receptors, Nicotinic / Q000235:genetics*; D012907:Smoking / Q000235:genetics*; D055815:Young Adult
chemical_list: C447158:CHRNA5 protein, human; D009419:Nerve Tissue Proteins; D011978:Receptors, Nicotinic; D009538:Nicotine; C585710:CYP2A6 protein, human; D065637:Cytochrome P-450 CYP2A6