title: Personality disorders, but not cancer severity or treatment type, are risk factors for later generalised anxiety disorder and major depressive disorder in non metastatic breast cancer patients.
abstract: This study aimed to determine whether personality disorders were associated with later Major Depressive Disorder (MDD) or Generalised Anxiety Disorder (GAD) in breast cancer patients. This longitudinal and multicentric study included 120 French non-metastatic breast cancer patients. After cancer diagnosis (T1) and 7 months after diagnosis (T3), we assessed MDD and GAD (Mini International Neuropsychiatric Interview 5.0). We assessed personality disorders 3 months after diagnosis (VKP). We used multiple logistic regression analysis to determine what were the factors associated with GAD and MDD at T3. At T3, prevalence rate was 10.8% for MDD and 19.2% for GAD. GAD at T3 was significantly and independently associated with GAD at T1 and with existence of a personality disorder, no matter the cluster type. MDD at T3 was significantly and independently associated with MDD at T1 and with the existence of a cluster C personality disorder. Initial cancer severity and the type of treatment used were not associated with GAD or MDD at T3. Breast cancer patients with personality disorders are at higher risk for GAD and MDD at the end of treatment. Patients with GAD should be screened for personality disorders. Specific interventions for patients with personality disorders could prevent psychiatric disorders.
authors.affiliation: CHRU de Tours, Clinique Psychiatrique Universitaire, 2 Boulevard Tonnellé, 37042 Tours Cedex 9, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Champagne
authors.affiliation: CHRU de Tours, Clinique Psychiatrique Universitaire, 2 Boulevard Tonnellé, 37042 Tours Cedex 9, France; CHRU de Tours, Équipe de Liaison et de Soins en Addictologie, 2 Boulevard Tonnellé, 37042 Tours Cedex 9, France; Université François Rabelais de Tours, Département de Psychologie, EA 2114 « Psychologie des Âges de la Vie », 3 rue des Tanneurs BP 4103, 37041 Tours Cedex 1, France. Electronic address: paul.brunault@univ-tours.fr.
authors.forename: Paul
authors.initials: P
authors.lastname: Brunault
authors.affiliation: CHRU de Tours, Clinique Psychiatrique Universitaire, 2 Boulevard Tonnellé, 37042 Tours Cedex 9, France.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Huguet
authors.affiliation: CHRU de Tours, Clinique Psychiatrique Universitaire, 2 Boulevard Tonnellé, 37042 Tours Cedex 9, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Suzanne
authors.affiliation: Centre Hospitalier Henri-Laborit, Service de Psychiatrie, 370 Avenue Jacques Cœur, 86021 Poitiers, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Senon
authors.affiliation: CHRU de Tours, Service de Gynécologie Obstétrique, 2 Boulevard Tonnellé, 37042 Tours Cedex 9, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Body
authors.affiliation: CHRU de Tours, Service d'Information Médicale, Epidémiologie et Economie de la Santé, 2 Boulevard Tonnellé, 37042 Tours Cedex 9, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Rusch
authors.affiliation: CHU de Poitiers, Service de Gynécologie Obstétrique, 2 rue de la Milétrie, 86021 Poitiers, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Magnin
authors.affiliation: Centre Hospitalier Henri-Laborit, Service de Psychiatrie, 370 Avenue Jacques Cœur, 86021 Poitiers, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Voyer
authors.affiliation: Université François Rabelais de Tours, Département de Psychologie, EA 2114 « Psychologie des Âges de la Vie », 3 rue des Tanneurs BP 4103, 37041 Tours Cedex 1, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Réveillère
authors.affiliation: CHRU de Tours, Clinique Psychiatrique Universitaire, 2 Boulevard Tonnellé, 37042 Tours Cedex 9, France; UMR INSERM U930, 2 boulevard Tonnellé, 37044 Tours Cedex, France; Université François Rabelais de Tours, 3 rue des Tanneurs BP 4103, 37041 Tours Cedex 1, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Camus
mesh_terms: D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D001943:Breast Neoplasms / Q000150:complications / Q000473:pathology* / Q000523:psychology*; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010554:Personality Disorders / Q000150:complications* / Q000523:psychology; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: Breast cancer; Generalised anxiety disorder; Major depressive disorder; Personality disorders; Psychiatric disorders; VKP