title: Sulforaphane exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia.
abstract: Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a promising target for treatment. Sulforaphane exerts protective effects in a rat model of focal cerebral ischemia/reperfusion injury by alleviating brain edema. However, the possible mechanisms of sulforaphane after cerebral ischemia/reperfusion injury have not been fully elucidated. Therefore, in the present study, we investigated the effect of sulforaphane on inflammatory reaction and the potential molecular mechanisms in cerebral ischemia rats. We found that sulforaphane significantly attenuated the blood-brain barrier (BBB) disruption; decreased the levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-1β; reduced the nitric oxide (NO) levels and inducible nitric oxide synthase (iNOS) activity; inhibited the expression of iNOS and cyclooxygenase-2 (COX-2). In addition, sulforaphane inhibits the expression of p-NF-κB p65 after focal cerebral ischemia-reperfusion injury. Taken together, our results suggest that sulforaphane suppresses the inflammatory response via inhibiting the NF-κB signaling pathway in a rat model of focal cerebral ischemia, and sulforaphane may be a potential therapeutic agent for the treatment of cerebral ischemia injury.
authors.affiliation: Department of Neurology, Yantaishan Hospital Yantai 264000, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Ma
authors.affiliation: Department of Neurology, Weifang People's Hospital Weifang 261599, China.
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Xing
authors.affiliation: Department of Neurosurgery, The Third Hospital (China-Japan Union Hospital) of Jilin University Changchun 130033, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Neurology, Yantaishan Hospital Yantai 264000, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Neurology, Yantaishan Hospital Yantai 264000, China.
authors.forename: Tian-Xia
authors.initials: TX
authors.lastname: Yu
authors.affiliation: Department of Neurology, Zhongshan Hospital, Xiamen University Xiamen 361004, China.
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Zheng
authors.affiliation: Department of Neurology, Zhongshan Hospital, Xiamen University Xiamen 361004, China.
authors.forename: Tian-Bao
authors.initials: TB
authors.lastname: Lai
keywords: Sulforaphane; focal cerebral ischemia; inflammatory response