title: Alterations of neocortico-limbic association fibers and correlation with diet in prediabetes diagnosed by impaired fasting glucose.
abstract: To assess the existence of alterations in the micro-integrity of the fasciculus in prediabetic subjects. The issue of micro-integrity in white matter tracts has not been adequately addressed in prediabetes.
  
  
  
  Sixty-four prediabetic subjects and 54 controls were enrolled. All participants completed 24-hour diet records and 3-day diet records and received diffusion tensor imaging at 3T. The data for white matter micro-integrity were analyzed and compared between prediabetic subjects and controls with age and gender as covariates. In addition, voxel-wise regression between white matter micro-integrity, diet, and preprandial glucose levels were used to explore the relationship between white matter micro-integrity and diet or serum glucose levels.
  
  
  
  We found that prediabetic subjects had significant reductions in the micro-integrity of bilateral anterior thalamic radiation, left inferior longitudinal fasciculus, and left superior longitudinal fasciculus (corrected P < 0.05). In addition, total carbohydrate intake amount and preprandial serum glucose levels were negatively correlated with the micro-integrity in the left inferior longitudinal fasciculus and left anterior thalamic radiation (r: -0.47, corrected P < 0.05).
  
  
  
  Restrictive alterations in the white matter micro-integrity of the anterior thalamic radiation and inferior and superior longitudinal fasciculi might represent the initial "hot spots" for white matter tract alterations, which might play a role in the development of prediabetes. J. Magn. Reson. Imaging 2016;43:1500-1506.
authors.affiliation: Department of Nutrition, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, ROC.
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Hou
authors.affiliation: School of Nutrition and Health Sciences, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan, ROC.
authors.forename: Shwu-Huey
authors.initials: SH
authors.lastname: Yang
authors.affiliation: Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan, ROC.|Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.|Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC.
authors.forename: Yu-Te
authors.initials: YT
authors.lastname: Wu
authors.affiliation: Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan, ROC.|Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.|Department of Psychiatry, Cheng Hsin General Hospital, Taipei City, Taiwan, ROC.
authors.forename: Chien-Han
authors.initials: CH
authors.lastname: Lai
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D004032:Diet / Q000379:methods; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D019579:Neocortex / Q000000981:diagnostic imaging / Q000473:pathology*; D011236:Prediabetic State / Q000378:metabolism* / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D001786:Blood Glucose
keywords: anterior thalamic radiation; inferior longitudinal fasciculus; prediabetes; superior longitudinal fasciculus; white matter