title: Ligand-Enabled, Copper-Promoted Regio- and Chemoselective Hydroxylation of Arenes, Aryl Halides, and Aryl Methyl Ethers.
abstract: We report here a practical method for the ortho C-H hydroxylation of benzamides with inexpensive copper(II) acetate monohydrate and a pyridine ligand. An intra- and intermolecular ligand combination was explored to achieve regio- and chemoselective hydroxylation. Interestingly, typical regiochemical scrambling associated with the C-H activation was further resolved by introducing a ligand-directed ortho hydroxylation of haloarenes and aryl methyl ethers.
authors.affiliation: Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India.|Academy of Scientific and Innovative Research , Kolkata-700032, West Bengal, India.
authors.forename: Bijaya Kumar
authors.initials: BK
authors.lastname: Singh
authors.affiliation: Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India.|Academy of Scientific and Innovative Research , Kolkata-700032, West Bengal, India.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Jana