title: Eccrine Angiomatous Hamartoma: A Clinicopathologic Review of 18 Cases.
abstract: BACKGROUND
  Eccrine angiomatous hamartoma (EAH) is a benign cutaneous lesion defined by the proliferation of hamartomatous eccrine and capillary-like vascular elements in the dermis. However, the epidemiologic, morphologic, and histopathologic aspects of this uncommon disorder have yet to be fully delineated.
  
  
  METHODS
  The authors retrospectively reviewed 18 EAH cases (including 14 accompanying skin biopsy specimens) diagnosed at 4 American university hospitals from 1996 to 2014.
  
  
  RESULTS
  Patients ranged from 3 days to 84 years at time of diagnosis with a median age of 15 years. A male:female ratio of 11:7 was observed. Sixty-seven percent of cases presented in the extremities, but lesions in the trunk and head/neck regions also occurred. Four patients had multiple lesions, and 2 displayed a segmental pattern. Histologically, dermal vascular dilatation and acanthosis often accompanied EAH's typical eccrine and vascular comingling. One individual developed EAH at the site of a recurrent squamous cell carcinoma after previous excision.
  
  
  CONCLUSIONS
  Although previously thought to occur primarily as a solitary angiomatous-appearing malformation on the extremities of children, EAH may develop with some frequency in adults and may manifest in a multifocal linear distribution. The authors also raise additional histopathologic consideration in support of the vascular theory of histogenesis for this condition.
authors.affiliation: *Ohio State University College of Medicine, Columbus, OH; †Department of Dermatology, Emory University School of Medicine, Atlanta, GA; ‡Division of Dermatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO; §Division of Dermatology, Nationwide Children's Hospital, Columbus, OH; ¶Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO; and ‖Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Patterson
authors.forename: Monique G
authors.initials: MG
authors.lastname: Kumar
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Bayliss
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Witman
authors.forename: Louis P
authors.initials: LP
authors.lastname: Dehner
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Gru
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004439:Eccrine Glands / Q000473:pathology*; D005260:Female; D006222:Hamartoma / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012871:Skin Diseases / Q000473:pathology*; D013543:Sweat Gland Diseases / Q000473:pathology*; D055815:Young Adult