title: [The heart and anticytokine therapy].
abstract: Treatment targeting TNF revolutionized management for rheumatoid arthritis patients offering attainment of clinical remission, preventing patients from disability and improving their quality of life. Anti-cytokine therapy, however may in some circumstance contribute to development of serious adverse effects, including congestive heart failure. The heart failure in patients treated with anti-TNF agents seems to be paradoxical as TNF plays an important pathogenetic role in both conditions. In congestive heart failure, TNF may act as a regulatory factor and may stabilize the heart function, so TNF blockade may result in progression of the heart failure. In this paper, the pathogenetic role of TNF has been discussed with the special emphasis to the role of cytokine in conditions of heart failure and systemic inflammation.
authors.forename: Przemysław J
authors.initials: PJ
authors.lastname: Kotyla
authors.forename: Eugeniusz J
authors.initials: EJ
authors.lastname: Kucharz
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000523:psychology; D016503:Drug Delivery Systems / Q000009:adverse effects*; D006333:Heart Failure / Q000139:chemically induced*; D006801:Humans; D011788:Quality of Life; D000079424:Tumor Necrosis Factor Inhibitors
chemical_list: D000079424:Tumor Necrosis Factor Inhibitors