title: Microalgal Oil Supplementation Has an Anti-Obesity Effect in C57BL/6J Mice Fed a High Fat Diet.
abstract: This study investigated the impact of microalgal oil (MO) on body weight management in C57BL/6J mice. Obesity was induced for 8 weeks and animals were orally supplemented with the following for 8 additional weeks: beef tallow (BT), corn oil, fish oil (FO), microalgal oil (MO), or none, as a high fat diet control group (HD). A normal control group was fed with a normal diet. After completing the experiment, the FO and MO groups showed significant decreases in body weight gain, epididymal fat pad weights, serum triglycerides, and total cholesterol levels compared to the HD and BT groups. A lower mRNA expression level of lipid anabolic gene and higher levels of lipid catabolic genes were observed in both FO and MO groups. Serum insulin and leptin concentrations were lower in the MO group. These results indicated that microalgal oil has an anti-obesity effect that can combat high fat diet-induced obesity in mice.
authors.affiliation: Department of Food Science and Human Nutrition, Brain Korea 21 Plus, Chonbuk National University, Jeonbuk 54896, Korea.
authors.forename: Jin-Seon
authors.initials: JS
authors.lastname: Yook
authors.affiliation: Department of Food and Nutrition, Songwon University, Gwanju 61756, Korea.
authors.forename: Kyung-Ah
authors.initials: KA
authors.lastname: Kim
authors.affiliation: Department of Food Science and Human Nutrition, Brain Korea 21 Plus, Chonbuk National University, Jeonbuk 54896, Korea.
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Park
authors.affiliation: Department of Food Science and Human Nutrition, Brain Korea 21 Plus, Chonbuk National University, Jeonbuk 54896, Korea.
authors.forename: Seon-Hwa
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Food Science and Human Nutrition, Brain Korea 21 Plus, Chonbuk National University, Jeonbuk 54896, Korea.
authors.forename: Youn-Soo
authors.initials: YS
authors.lastname: Cha
keywords: lipid profile; microalgae; obesity; omega-3; polyunsaturated fatty acids