title: Rhodium complexes as therapeutic agents.
abstract: The landscape of inorganic medicinal chemistry has been dominated by the investigation of platinum, and to a lesser extent ruthenium, complexes over the past few decades. Recently, complexes based on other metal centers such as rhodium have attracted attention due to their tunable chemical and biological properties as well as distinct mechanisms of action. This perspective highlights recent examples of rhodium complexes that show diverse biological activities against various targets, including enzymes and protein-protein interactions.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. edmondma@hkbu.edu.hk.
authors.forename: Dik-Lung
authors.initials: DL
authors.lastname: Ma
authors.forename: Modi
authors.initials: M
authors.lastname: Wang
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Mao
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.forename: Chan-Tat
authors.initials: CT
authors.lastname: Ng
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Leung
mesh_terms: D000818:Animals; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D056831:Coordination Complexes; D012238:Rhodium