title: The Synthesis of Structurally Diverse Macrocycles By Successive Ring Expansion.
abstract: Structurally diverse macrocycles and medium-sized rings (9-24 membered scaffolds, 22 examples) can be generated through a telescoped acylation/ring-expansion sequence, leading to the insertion of linear fragments into cyclic β-ketoesters without performing a discrete macrocyclization step. The key β-ketoester motif is regenerated in the ring-expanded product, meaning that the same sequence of steps can then be repeated (in theory indefinitely) with other linear fragments, allowing macrocycles with precise substitution patterns to be "grown" from smaller rings using the successive ring-expansion (SuRE) method.
authors.affiliation: University of York, York, YO24 4PP (UK).
authors.forename: Christiana
authors.initials: C
authors.lastname: Kitsiou
authors.affiliation: University of York, York, YO24 4PP (UK).
authors.forename: Jordan J
authors.initials: JJ
authors.lastname: Hindes
authors.affiliation: University of York, York, YO24 4PP (UK).
authors.forename: Phillip
authors.initials: P
authors.lastname: I'Anson
authors.affiliation: University of York, York, YO24 4PP (UK).
authors.forename: Paula
authors.initials: P
authors.lastname: Jackson
authors.affiliation: University of York, York, YO24 4PP (UK).
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Wilson
authors.affiliation: University of York, York, YO24 4PP (UK).
authors.forename: Eleanor K
authors.initials: EK
authors.lastname: Daly
authors.affiliation: University of York, York, YO24 4PP (UK).
authors.forename: Hannah R
authors.initials: HR
authors.lastname: Felstead
authors.affiliation: University of York, York, YO24 4PP (UK).
authors.forename: Peter
authors.initials: P
authors.lastname: Hearnshaw
authors.affiliation: University of York, York, YO24 4PP (UK). william.unsworth@york.ac.uk.
authors.forename: William P
authors.initials: WP
authors.lastname: Unsworth
keywords: macrocycles; medium-sized rings; rearrangement; ring expansion; structural diversity