title: Prevalence of Cytomegalovirus IgG Antibodies among Pregnant Women Visiting Antenatal Clinic, LAUTECH Teaching Hospital in Osogbo, Osun State, Nigeria.
abstract: Cytomegalovirus (CMV) is one of the predominant viral infections that lead to congenital diseases and teratogenic risks during the perinatal stage. There is paucity of seroepidemiological data on anti-CMV IgG antibody in pregnant women in Osogbo, Osun State, Nigeria. This study was aimed at determining the seroprevalence of Cytomegalovirus IgG antibody among pregnant women visiting antenatal clinic, LAUTECH Teaching Hospital, Osogbo, Nigeria. One hundred and seventy-four sera from the pregnant women were screened by Enzyme linked Immunosorbent Assay (ELISA) for cytomegalovirus (CMV) IgG antibody. Data analysis was done using SPSS software. In this study, 105 of the 174 pregnant women were seropositive for CMV IgG antibodies giving an antibody prevalence of 60%. There was no association found between CMV IgG seropositivity and the subjects' demographic characteristics, however, the 60.0% prevalence of CMV-IgG antibody observed amongst pregnant women in this study demands for vaccines and regular testing for the presence of CMV and its related risk factors in antenatal clinic.
authors.affiliation: a Department of Medical Microbiology and Parasitology , College of Health Sciences, Ladoke Akintola University of Technology , Osogbo , Nigeria.
authors.forename: Oluwatosin
authors.initials: O
authors.lastname: Akende
authors.affiliation: a Department of Medical Microbiology and Parasitology , College of Health Sciences, Ladoke Akintola University of Technology , Osogbo , Nigeria.
authors.forename: Olusola Anuoluwapo
authors.initials: OA
authors.lastname: Akanbi
authors.affiliation: a Department of Medical Microbiology and Parasitology , College of Health Sciences, Ladoke Akintola University of Technology , Osogbo , Nigeria.
authors.forename: Adeolu Sunday
authors.initials: AS
authors.lastname: Oluremi
authors.affiliation: b Medical Microbiology Unit, Department of Microbiology , University of Port Harcourt , Port Harcourt , Rivers State , Nigeria.
authors.forename: Iheanyi Omezuruike
authors.initials: IO
authors.lastname: Okonko
authors.affiliation: a Department of Medical Microbiology and Parasitology , College of Health Sciences, Ladoke Akintola University of Technology , Osogbo , Nigeria.
authors.forename: Oluyinka Oladele
authors.initials: OO
authors.lastname: Opaleye
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology*; D003430:Cross-Sectional Studies; D003587:Cytomegalovirus / Q000276:immunology* / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology*; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D011247:Pregnancy
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G
keywords: CMV; Nigeria; immunoglobulin G; pregnant women; seropositivity