title: From bone marrow transplantation to complex biological therapy.
abstract: The major complications after bone marrow transplant are related to opportunistic infections or to graft-versus-host disease. Today, there is a wealth of information associated with bone marrow transplantation and new treatment approaches have been proposed to overcome these complications. Behind these new therapies, such as adoptive transfer of T cells or mesenchymal stem cell infusions, there is significant basic research to support these clinical advances. Most of this knowledge has derived from the development of animal models and intense laboratory work to test and confirm hypotheses. There is no doubt that basic research is still necessary to better understand the basis for clinical outcome improvements.
authors.affiliation: Instituto Israelita de Ensino e Pesquisa Albert Einstein - IIEPAE, São Paulo, SP, BR.
authors.forename: Luciana Cavalheiro
authors.initials: LC
authors.lastname: Marti
authors.affiliation: Instituto Israelita de Ensino e Pesquisa Albert Einstein - IIEPAE, São Paulo, SP, BR.
authors.forename: Luiz Vicente
authors.initials: LV
authors.lastname: Rizzo