title: A novel liposomal Clodronate depletes tumor-associated macrophages in primary and metastatic melanoma: Anti-angiogenic and anti-tumor effects.
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, 16147 Genoa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Piaggio
authors.affiliation: Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Centre for Molecular Medicine (CMMC), University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Kondylis
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, 16147 Genoa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pastorino
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, 16147 Genoa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Di Paolo
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, 16147 Genoa, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Perri
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, 16147 Genoa, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Cossu
authors.affiliation: Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Centre for Molecular Medicine (CMMC), University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Schorn
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, 70124 Bari, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Marinaccio
authors.affiliation: Department of Pathology, Istituto Giannina Gaslini, 16147 Genoa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Murgia
authors.affiliation: Laboratorio di Trasferimento Genico, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Daga
authors.affiliation: Laboratory of Molecular Biology, Istituto Giannina Gaslini, 16147 Genoa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Raggi
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, 16147 Genoa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Loi
authors.affiliation: Animal Facility, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Emionite
authors.affiliation: Animal Facility, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Ognio
authors.affiliation: Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Centre for Molecular Medicine (CMMC), University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Pasparakis
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, 70124 Bari, Italy; National Cancer Institute "Giovanni Paolo II", 70124 Bari, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Ribatti
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, 16147 Genoa, Italy. Electronic address: mircoponzoni@ospedale-gaslini.ge.it.
authors.forename: M
authors.initials: M
authors.lastname: Ponzoni
authors.affiliation: Laboratory of Oncology, Istituto Giannina Gaslini, 16147 Genoa, Italy. Electronic address: chiarabrignole@ospedale-gaslini.ge.it.
authors.forename: C
authors.initials: C
authors.lastname: Brignole
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004002:Clodronic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D016207:Cytokines / Q000276:immunology; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008081:Liposomes; D008099:Liver / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008822:Mice, Transgenic; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines; D005229:Fatty Acids, Monounsaturated; D008081:Liposomes; D000644:Quaternary Ammonium Compounds; D004002:Clodronic Acid; C070046:1,2-dioleoyloxy-3-(trimethylammonium)propane
keywords: Adjuvant therapy; Liposomal Clodronate; Melanoma; TAMs