title: Role of circulating nesfatin-1 in the underweight children with poor appetite.
abstract: OBJECTIVE
  To investigate serum concentration of nesfatin-1 in underweight children who have poor appetite, and its association with anthropometric markers of malnutrition.
  
  
  METHODS
  We recruited 50 underweight children and adolescents (aged 2-18 years) who presented with loss of appetite. Thirty age- and sex-matched controls were also included in the study. Fasting serum nesfatin-1 concentrations were measured by using Enzyme-Linked Immunosorbent Assay (ELISA) technique.
  
  
  RESULTS
  Mean nesfatin-1 level was significantly higher in underweight children when compared to controls (p<0.001). There was no correlation between serum nesfatin-1 levels and anthropometrics markers.
  
  
  CONCLUSIONS
  Our results suggest that nesfatin-1 might have an important role in regulation of food intake and pathogenesis of loss of appetite in children.
authors.affiliation: Department of Pediatrics, Division of Pediatric Endocrinology, Yüzüncü Yıl University, School of Medicine, Van, Turkey. sultan33kaba@hotmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Kaba
authors.forename: K
authors.initials: K
authors.lastname: Karaman
authors.forename: U
authors.initials: U
authors.lastname: Kömüroğlu
authors.forename: K
authors.initials: K
authors.lastname: A Bala
authors.forename: N
authors.initials: N
authors.lastname: Demir
authors.forename: S
authors.initials: S
authors.lastname: Kocaman
authors.forename: M
authors.initials: M
authors.lastname: Doğan
authors.forename: N
authors.initials: N
authors.lastname: Ceylan
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001066:Appetite / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000097:blood*; D002648:Child; D015362:Child Nutrition Disorders / Q000097:blood* / Q000175:diagnosis; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000097:blood*; D004435:Eating / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D013851:Thinness / Q000097:blood* / Q000175:diagnosis
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins