title: Decreased Interleukin-10 Responses in Children with Severe Mycoplasma pneumoniae Pneumonia.
abstract: Several cytokines may play roles in the immunological pathogenesis of mycoplasmal pneumonia caused by Mycoplasma pneumoniae. In this study, we investigated serum cytokine profiles in children with mycoplasmal pneumonia. The serum levels of interleukin (IL)-8, IL-10, and IL-18 were examined using ELISA kits in 34 patients with M. pneumoniae infection (Group 1, 11 with severe mycoplasmal pneumonia; Group 2, 13 with mild mycoplasmal pneumonia; Group 3, 10 with asthma) and 32 age-matched, non-infected controls. The serum levels of IL-8, IL-10, and IL-18 increased significantly in patients with mycoplasmal pneumonia compared with those in controls (P<0.01). The serum levels of IL-10 decreased significantly in Group 1 compared with those in Group 2 (P<0.01). The serum levels of IL-18 increased significantly in Group 1 compared with those in Group 2 (P<0.01). The serum levels of IL-10 and IL-18 decreased significantly in 10 M. pneumoniae-infected patients with asthma compared with those in 24 M. pneumoniae-infected patients without asthma (P<0.01). We examined the level of interleukins (IL-8, IL-10 and IL-18) after the patients started therapy. The data showed that IL-18 were lower after therapy (P<0.01). Collectively, our data suggested that these cytokines may be involved in the pathogenesis of mycoplasmal pneumonia.
authors.affiliation: Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Shenggang
authors.initials: S
authors.lastname: Ding
authors.affiliation: Department of Microbiology, Anhui Medical University, Hefei, Anhui, China.|Department of Clinical Laboratory, Fuyang Second People's Hospital, Fuyang, Anhui, China.
authors.forename: Xiaowu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Microbiology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Microbiology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of Microbiology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Boyu
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Microbiology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Respiratory Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Guanghe
authors.initials: G
authors.lastname: Fei
authors.affiliation: Department of Microbiology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Linding
authors.initials: L
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D001249:Asthma / Q000382:microbiology / Q000503:physiopathology; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood; D018655:Lymphocyte Count; D008297:Male; D009177:Mycoplasma pneumoniae; D011019:Pneumonia, Mycoplasma / Q000097:blood* / Q000276:immunology*
chemical_list: D000900:Anti-Bacterial Agents; C508606:CXCL8 protein, human; D016207:Cytokines; C508609:IL10 protein, human; D016209:Interleukin-8; D016753:Interleukin-10; D002097:C-Reactive Protein