title: To Serve and Protect: Hydrogels to Improve Stem Cell-Based Therapies.
abstract: Harsh environments within damaged and diseased tissues and limited retention and survival of injected stem cells pose major challenges for stem cell therapeutics today. Here, we discuss promising hydrogel-based strategies for improving engraftment and viability of transplanted stem cells and stimulating recruitment of endogenous stem cells for repair.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: burdick2@seas.upenn.edu.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Burdick
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Mauck
authors.affiliation: Department of Chemical and Biomolecular Engineering and the Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Sharon
authors.initials: S
authors.lastname: Gerecht
mesh_terms: D019070:Cell Lineage; D002470:Cell Survival; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007249:Inflammation; D009389:Neovascularization, Pathologic; D010455:Peptides / Q000737:chemistry; D015398:Signal Transduction; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology*; D014945:Wound Healing
chemical_list: D020100:Hydrogels; D010455:Peptides