title: Neonatal lupus erythematosus: a cutaneous cases based update.
abstract: BACKGROUND
  Neonatal Lupus Erythematosus (NLE) is an uncommon autoimmune disease characterized by cutaneous, hepatic, hematological, neurological and cardiac involvement.
  
  
  METHODS
  Here we report four cases of cutaneous NLE which were referred to our department in the last 10 years and update literature. The newborns presented with different skin, clinical and laboratory features. This underlines the phenotypic variability of NLE. We investigated the passage of maternal antinuclear antibodies (ANA) and extractable nuclear antigen antibodies (ENA) - particularly anti-Ro/SSA, anti-La/SSB and anti-U1 ribonucleoprotein RNP - through the placenta. Despite the positive family background, cutaneous NLE and serological data improved in infants within 4 months without treatment.
  
  
  CONCLUSIONS
  The evolution of cutaneous NLE may be the spontaneous regression of lesions within six months without progression to Systemic Lupus Erytehmatosus.
authors.affiliation: Department of Pediatrics and Adolescence - Regina Margherita Children's Hospital, Azienda Ospedaliera Città della Salute e della Scienza di Torino, University of Turin, Piazza Polonia, 94, Torino, 10126, Italy. francesco.savino@unito.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Savino
authors.affiliation: Department of Pediatrics and Adolescence - Regina Margherita Children's Hospital, Azienda Ospedaliera Città della Salute e della Scienza di Torino, University of Turin, Piazza Polonia, 94, Torino, 10126, Italy. viola.serena@libero.it.
authors.forename: Serena
authors.initials: S
authors.lastname: Viola
authors.affiliation: Department of Pediatrics and Adolescence - Regina Margherita Children's Hospital, Azienda Ospedaliera Città della Salute e della Scienza di Torino, University of Turin, Piazza Polonia, 94, Torino, 10126, Italy. valentina.tarasco@libero.it.
authors.forename: Valentina
authors.initials: V
authors.lastname: Tarasco
authors.affiliation: Department of Pediatrics and Adolescence - Regina Margherita Children's Hospital, Azienda Ospedaliera Città della Salute e della Scienza di Torino, University of Turin, Piazza Polonia, 94, Torino, 10126, Italy. manulocatelli@libero.it.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Locatelli
authors.affiliation: Department of Pediatrics and Adolescence - Regina Margherita Children's Hospital, Azienda Ospedaliera Città della Salute e della Scienza di Torino, University of Turin, Piazza Polonia, 94, Torino, 10126, Italy. alberto.ricagni@edu.unito.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ricagni
authors.affiliation: Department of Surgery, Dermatology Unit, Regina Margherita Children's Hospital, University of Turin, Turin, Italy. coppo.paola@gmail.com.
authors.forename: Paola
authors.initials: P
authors.lastname: Coppo
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006257:Head; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008178:Lupus Erythematosus, Cutaneous / Q000151:congenital* / Q000628:therapy*; D008297:Male