title: Expanding the diversity of DNA base modifications with N⁶-methyldeoxyadenosine.
abstract: Vertebrate DNA is subjected to epigenetic base modifications that have been thought to be limited to methylated and other modified forms of cytidine. A recent study shows that methylation of adenine to form N (6)-methyladenine is a rare but readily detectable modification that can be mapped to distinct genomic sites in vertebrates.
authors.affiliation: Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY, 10065, USA.
authors.forename: Kate D
authors.initials: KD
authors.lastname: Meyer
authors.affiliation: Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY, 10065, USA. srj2003@med.cornell.edu.
authors.forename: Samie R
authors.initials: SR
authors.lastname: Jaffrey
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000737:chemistry; D000818:Animals; D020029:Base Pairing / Q000235:genetics; D004247:DNA / Q000235:genetics*; D019175:DNA Methylation / Q000235:genetics*; D044127:Epigenesis, Genetic; D014644:Genetic Variation; D014714:Vertebrates / Q000235:genetics
chemical_list: C073276:N(6)-methoxyadenine; D004247:DNA; D000225:Adenine