title: Co-exposure of ELF-magnetic fields and chemical mutagens: An investigation of genotoxicity with the SOS-based VITOTOX test in Salmonella typhimurium.
abstract: It is believed that extreme low frequency magnetic fields (ELF-MF) are not mutagenic, at least at exposure levels below 100 μT. Synergistic or co-operative effects with environmental mutagens remain possible yet. We therefore investigated the effects of ELF-MF in conjunction with 4 different well known chemical mutagens having different modes of action. For this purpose the bacterial Vitotox test was used. Our study confirmed previous results which showed that a 100 μT magnetic field (50 Hz) does not damage DNA and hence is not mutagenic in this assay and that there was also no influence on the DNA damaging capacity of the used mutagens.
authors.affiliation: Scientific Institute of Public Health (WIV-ISP), Toxicology Unit, Brussels, Belgium; University of Antwerp, Department of Biomedical Research, Antwerp, Belgium. Electronic address: luc.verschaeve@wiv-isp.be.
authors.forename: Luc
authors.initials: L
authors.lastname: Verschaeve
authors.affiliation: Scientific Institute of Public Health (WIV-ISP), Toxicology Unit, Brussels, Belgium; Free University of Brussels, Faculty of Pharmacy, Brussels, Belgium.
authors.forename: Sheleen
authors.initials: S
authors.lastname: Wambacq
authors.affiliation: Scientific Institute of Public Health (WIV-ISP), Toxicology Unit, Brussels, Belgium.
authors.forename: Roel
authors.initials: R
authors.lastname: Anthonissen
authors.affiliation: Scientific Institute of Public Health (WIV-ISP), Toxicology Unit, Brussels, Belgium.
authors.forename: Annemarie
authors.initials: A
authors.lastname: Maes
mesh_terms: D004249:DNA Damage; D004269:DNA, Bacterial / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D060526:Magnetic Fields / Q000009:adverse effects*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D013014:SOS Response, Genetics; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000528:radiation effects*
chemical_list: D004269:DNA, Bacterial; D009153:Mutagens
keywords: Chemical mutagens; Co-exposure; ELF-MF; Genotoxicity; Vitotox test