title: Des-acyl ghrelin prevents heatstroke-like symptoms in rats exposed to high temperature and high humidity.
abstract: We have shown previously that des-acyl ghrelin decreases body temperature in rats through activation of the parasympathetic nervous system. Here we investigated whether des-acyl ghrelin ameliorates heatstroke in rats exposed to high temperature. Peripheral administration of des-acyl ghrelin significantly attenuated hyperthermia induced by exposure to high-temperature (35°C) together with high humidity (70-80%). Although biochemical analysis revealed that exposure to high temperature significantly increased hematocrit and the serum levels of aspartate amino transferase (AST), alanine transaminase (ALT), blood urea nitrogen (BUN), creatinine and electrolytes (Na(+), K(+), Cl(-)), most of these heatstroke-associated reactions were significantly reduced by treatment with des-acyl ghrelin. The level of des-acyl ghrelin in plasma was also found to be significantly increased under high-temperature conditions. These results suggest that des-acyl ghrelin could be useful for preventing heatstroke under high temperature condition.
authors.affiliation: Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Asubio Pharma Co., Ltd., 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Department of Biochemistry, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kangawa
authors.affiliation: Laboratory of Animal Health Science, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Murakami
authors.affiliation: Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan. Electronic address: a0d209u@cc.miyazaki-u.ac.jp.
authors.forename: Keiko
authors.initials: K
authors.lastname: Nakahara
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D001831:Body Temperature / Q000187:drug effects; D002712:Chlorides / Q000097:blood; D003404:Creatinine / Q000097:blood; D004573:Electrolytes; D054439:Ghrelin / Q000097:blood / Q000627:therapeutic use*; D018883:Heat Stroke / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D006400:Hematocrit; D006358:Hot Temperature / Q000009:adverse effects*; D006813:Humidity / Q000009:adverse effects*; D008297:Male; D011188:Potassium / Q000097:blood; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood
chemical_list: D002712:Chlorides; D004573:Electrolytes; D054439:Ghrelin; C422650:ghrelin, des-n-octanoyl; D012964:Sodium; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011188:Potassium
keywords: Body temperature; Des-acyl ghrelin; Heatstroke