title: Histological analysis of the repair of dural lesions with silicone mesh in rats subjected to experimental lesions.
abstract: OBJECTIVE
  To evaluate inflammatory reaction, fibrosis and neovascularization in dural repairs in Wistar rats using four techniques: simple suture, bovine collagen membrane, silicon mesh and silicon mesh with suture.
  
  
  METHODS
  Thirty Wistar rats were randomized in five groups: the first was the control group, submitted to dural tear only. The others underwent durotomy and simple suture, bovine collagen membrane, silicon mesh and silicon mesh with suture. Animals were euthanized and the spine was submitted to histological evaluation with a score system (ranging from zero to 3) for inflammation, neovascularization and fibrosis.
  
  
  RESULTS
  Fibrosis was significantly different between simple suture and silicon mesh (p=0.005) and between simple suture and mesh with suture (p=0.015), showing that fibrosis is more intense when a foreign body is used in the repair. Bovine membrane was significantly different from mesh plus suture (p=0.011) regarding vascularization. Inflammation was significantly different between simple suture and bovine collagen membrane.
  
  
  CONCLUSIONS
  Silicon mesh, compared to other commercial products available, is a possible alternative for dural repair. More studies are necessary to confirm these findings.
authors.affiliation: Faculdade de Medicina do ABC, Santo André, SP, Brazil.
authors.forename: Fernando William Figueiredo da
authors.initials: FW
authors.lastname: Rosa
authors.affiliation: Faculdade de Medicina do ABC, Santo André, SP, Brazil.
authors.forename: Pedro Henrique Isoldi
authors.initials: PH
authors.lastname: Pohl
authors.affiliation: Faculdade de Medicina do ABC, Santo André, SP, Brazil.
authors.forename: Ana Maria Amaral Antônio
authors.initials: AM
authors.lastname: Mader
authors.affiliation: Faculdade de Medicina do ABC, Santo André, SP, Brazil.
authors.forename: Carla Peluso de
authors.initials: CP
authors.lastname: Paiva
authors.affiliation: Faculdade de Medicina do ABC, Santo André, SP, Brazil.
authors.forename: Aline Amaro dos
authors.initials: AA
authors.lastname: Santos
authors.affiliation: Faculdade de Medicina do ABC, Santo André, SP, Brazil.
authors.forename: Bianca
authors.initials: B
authors.lastname: Bianco
authors.affiliation: Faculdade de Medicina do ABC, Santo André, SP, Brazil.
authors.forename: Luciano Miller Reis
authors.initials: LM
authors.lastname: Rodrigues
mesh_terms: D000818:Animals; D002417:Cattle; D004195:Disease Models, Animal; D004388:Dura Mater / Q000098:blood supply / Q000293:injuries* / Q000473:pathology* / Q000601:surgery; D005355:Fibrosis; D008297:Male; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D024041:Non-Fibrillar Collagens / Q000627:therapeutic use; D011897:Random Allocation; D017208:Rats, Wistar; D012828:Silicones / Q000494:pharmacology / Q000627:therapeutic use*; D013526:Surgical Mesh; D013536:Suture Techniques / Q000706:statistics & numerical data; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D024041:Non-Fibrillar Collagens; D012828:Silicones