title: FCRL3 gene polymorphisms as risk factors for rheumatoid arthritis.
abstract: BACKGROUND
  Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease. As a member of FCRLs clusters, Fc receptor-like 3 (FCRL3) has been recognized as a neoteric autoimmune activation factor for RA. The aim of our study is to evaluate the correlation between four single-nucleotide polymorphisms (SNPs) on FCRL3 and RA risk in a Chinese Han population.
  
  
  METHODS
  The hospital-based case-control study included 630 RA patients together with 696 healthy individuals as the control group and all subjects are Chinese ancestry. Four tagging single-nucleotide polymorphisms (tag-SNPs) on FCRL3 were selected and genotyped by TaqMan assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were employed to evaluate the correlations between FCRL3 polymorphisms and RA. A systematic meta-analysis was also carried out based on the present study and previously published studies to further examine the association between FCRL3 variations and RA risk.
  
  
  RESULTS
  Significant association was found between -169T/C SNP and RA risk (CC vs. TT, OR=1.62, 95% CI=1.18-2.22; TC/CC vs. TT, OR=1.47, 95% CI=1.18-1.84; C vs. T, OR=1.32, 95% CI=1.12-1.54). Apart from that, mutations of -169T/C was significantly correlated with rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA) positive status. The meta-analysis also suggested that -169T/C mutation might have positive correlation with risk of RA in the overall population, particularly for Asian. Stratified analysis based on clinical characteristics of RF and ACPA also provided evidence that -169T/C polymorphisms could alter phenotypes of RA.
  
  
  CONCLUSIONS
  The FCRL3 -169T/C variant was significantly linked with an increased RA risk in the Chinese Han population. Moreover, this meta-analysis also provides notion that -169T/C variant could act as a susceptible factor for RA. However, further investigations about the functional impacts of this polymorphism are essential to confirm the above conclusions.
authors.affiliation: Department of Orthopedics, Fujian Provincial People's Hospital, 817 Road #602, Fuzhou 350004, Fujian, China. Electronic address: drlinxin@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Orthopedics, Fujian Provincial People's Hospital, 817 Road #602, Fuzhou 350004, Fujian, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, Fujian Provincial People's Hospital, 817 Road #602, Fuzhou 350004, Fujian, China.
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Chen
mesh_terms: D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D012307:Risk Factors
chemical_list: C457775:FCRL3 protein, human; D011971:Receptors, Immunologic
keywords: Anti-cyclic citrullinated peptide antibody (ACPA); Fc receptor-like 3 (FCRL3); Rheumatoid arthritis (RA); Rheumatoid factor (RF); Single-nucleotide polymorphism (SNP)