title: Association between polymorphism of the norepinephrine transporter gene rs2242446 and rs5669 loci and depression disorders.
abstract: OBJECTIVE
  To explore the association between polymorphism of the norepinephrine transporter (NET) gene rs2242446 and rs5669 loci and depression in Chinese Han population.
  
  
  METHODS
  A case-control study was carried out, the gene types and allele distributions of NFT gene rs2242446 and rs5569 loci in 302 depression patients and 302 healthy controls were detected by Taqman SNP genotyping technology.
  
  
  RESULTS
  The gene types and allele frequency distributions of NFT gene rs2242446 and rs5569 loci had significant differences between case group and control group (rs2242446, x(2)=26.045, P<0.05, x(2)=8.827, P<0.05, rs5569, x(2)=42.47, P<0.05, x(2)=20.9, P<0.05). The CC genotype of NET gene rs2242446 locus and rs5569 loci was a protective factor of depression compared with the CT and TT genotypes.
  
  
  CONCLUSIONS
  The NET genepoly morphism of rs2242446 and rs5569 loci was a ssociated with depression in Chinese Han population, in which the CC genotype of rs2242446 and rs5569 loci was a protective factor of depression.
authors.affiliation: Department of Psychology and Mental Health, Second Military Medical UniversityShanghai, China; Department of Medical Psychology, General Hospital of PLABeijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Juvenile and Children's Behavioral Medicine, 102 Hospital of PLA Changzhou, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: Department of 215 Clinical, Sleeping Center, Dalian Nursing Home Dalian, China.
authors.forename: Mo-Shui
authors.initials: MS
authors.lastname: Shan
authors.affiliation: Department of Psychology and Mental Health, Second Military Medical University Shanghai, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yan
keywords: Depression; norepinephrine transporter gene