title: Uterine fibroid: common features of widespread tumor (Review article).
abstract: Leiomyoma is the most frequent benign monoclonal tumor (cells behave identically in culture) of the female reproductive system. It affected almost 50% of childbearing age women, deteriorating the quality of life and may cause infertility. The unique features of this pathology is the absence of detailed understanding of pathogenic mechanisms and continuous morbidity among any age groups. Despite the huge amount of articles and studies related to leiomyoma, review pretend to depict herein actual and non-trivial information. This review assemble a versatile description of medical and biological aspects of leiomyomas. Explanation of genetic, molecular, pathophysiological mechanisms of uterine fibroid growing predetermine marked clinical symptoms of pathology. Mentioned model systems show multivariation of leiomyomas in human and animals. Review gives an opportunity analyze separate facets and collect it in one deep understanding of leiomyomas.
authors.affiliation: Department of Pathophysiology, Jagiellonian University, Medical College, Czysta 18,Krakow, Poland.
authors.forename: Veronika
authors.initials: V
authors.lastname: Aleksandrovych
authors.forename: Tomasz
authors.initials: T
authors.lastname: Bereza
authors.forename: Marek
authors.initials: M
authors.lastname: Sajewicz
authors.forename: Jerzy A
authors.initials: JA
authors.lastname: Walocha
authors.affiliation: Department of Pathophysiology, Jagiellonian University, Medical College, Czysta 18,Krakow, Poland. mpgil@cyf-kr.edu.pl.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Gil
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology*; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D014594:Uterine Neoplasms / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology*; D016387:Women's Health
keywords: endometrium; infertility; leyomyoma; myometrium; steroid hormones; uterine fibroid