title: Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase.
abstract: The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions.
authors.affiliation: Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Iwakiri
mesh_terms: D042783:Endothelial Cells / Q000378:metabolism; D055166:Hepatic Stellate Cells / Q000378:metabolism; D006801:Humans; D007728:Kupffer Cells / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism / Q000473:pathology*; D009569:Nitric Oxide / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D022661:RNA, Untranslated / Q000378:metabolism
chemical_list: D022661:RNA, Untranslated; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II
keywords: Hepatic stellate cell; Kupffer cell; Liver sinusoidal endothelial cell; NO; iNOS