title: The clinical characteristics of 80 cases of acquired immunodeficiency syndrome-associated Kaposi's sarcoma in Xinjiang Autonomous Region and the effect of different treatments on the prognosis.
abstract: To analyze the clinical features of AIDS-related Kaposi's sarcoma (AIDS-KS) patients in Xinjiang Autonomous Region and the impact of CD4 (+)T lymphocyte count, highly active antiretroviral therapy (HAART) and systemic chemotherapy on the prognosis. The clinical information of 80 AIDS-KS patients admitted in Sixth People's Hospital of Xinjiang Autonomous Region from January 2008 to August 2014 was retrospectively reviewed. Population characteristics, extent of lesions, KS progress, CD4 (+)T lymphocyte count, combined opportunistic infections, treatment and prognosis of these patients were analyzed. The 80 patients were divided into five groups according to treatment methods, including HAART, HAART + chemotherapy, chemotherapy + HAART, chemotherapy, and untreated groups. The efficacy and prognosis of the five groups were compared. Among the 80 patients, 74 (92.50%) patients were Uygur. The average age was 39.5±9.9 years and male-to-female ratio was 3:1. The median of baseline CD4 (+)T lymphocyte count was 152.5 cells/μL and the interquartile was 233.25 cells/μL. CD4 (+)T lymphocyte counts were significantly increased after treatment in HAART, HAART + chemotherapy, and chemotherapy + HAART groups (P < 0.05). CD4 (+)T lymphocyte count in chemotherapy groups was significantly reduced after treatment (P < 0.05). The untreated group had the highest mortality rate (33.3%). In HAART group, KS-associated immune reconstitution inflammatory response syndrome (KS-IRIS) appeared in 45.5% cases and 2 death cases were caused by KS-IRIS. In Xinjiang Autonomous Region, the incidence of AIDS-KS is high in young Uygur male people. HAART followed by chemotherapy has ideal efficacy, reduces the incidence of KS-IRIS and improves the prognosis.
authors.affiliation: Department of Infectious Diseases, Sixth People's Hospital of Xinjiang Urumqi, P. R. China.
authors.forename: Tongtong
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Infectious Diseases, The First Teaching Hospital of Xinjiang Medical University Urumqi, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Dermatology, The First Teaching Hospital of Xinjiang Medical University Urumqi, P. R. China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wan
authors.affiliation: Department of Infectious Diseases, The First Teaching Hospital of Xinjiang Medical University Urumqi, P. R. China.
authors.forename: Wubuli
authors.initials: W
authors.lastname: Maimaitiaili
authors.affiliation: Department of Infectious Diseases, Sixth People's Hospital of Xinjiang Urumqi, P. R. China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Infectious Diseases, The First Teaching Hospital of Xinjiang Medical University Urumqi, P. R. China.
authors.forename: Yuexin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, The First Teaching Hospital of Xinjiang Medical University Urumqi, P. R. China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Lu
keywords: Kaposi’s sarcoma; acquired immunodeficiency syndrome; prognosis