title: Effects of Barium Chloride Exposure on Hormones and Genes of the Hypothalamic-Pituitary-Gonad Axis, and Reproduction of Zebrafish (Danio rerio).
abstract: Adult zebrafish pairs were exposed to sub-lethal concentrations of BaCl2 for 21 days, and the effects on reproduction, sex steroid hormones, and transcription of the genes belonging to the hypothalamic-pituitary-gonad (HPG) axis were investigated. The adverse effects on performances of F1 generation were further examined with or without subsequent exposure to BaCl2. Egg production was significantly decreased, and parental exposure to BaCl2 resulted in lesser rates of hatching. In males, exposure to BaCl2 resulted in greater concentrations of E2 along with greater mRNA expression of cyp19a. The results demonstrated that BaCl2 could modulate gene transcriptions and hormone production of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring.
authors.affiliation: Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea.
authors.forename: Bareum
authors.initials: B
authors.lastname: Kwon
authors.affiliation: Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea.
authors.forename: Nayoung
authors.initials: N
authors.lastname: Ha
authors.affiliation: Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea.
authors.forename: Joeun
authors.initials: J
authors.lastname: Jung
authors.affiliation: Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea.
authors.forename: Pan-Gyi
authors.initials: PG
authors.lastname: Kim
authors.affiliation: Department of Health, Environment and Safety, Eulji University, Gyeonggi, Seongnam, 13135, Republic of Korea.
authors.forename: Younglim
authors.initials: Y
authors.lastname: Kho
authors.affiliation: Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea.
authors.forename: Kyungho
authors.initials: K
authors.lastname: Choi
authors.affiliation: Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea. kyungheeji@yongin.ac.kr.|Department of Occupational and Environmental Health, Yongin University, Yongin, 17092, Republic of Korea. kyungheeji@yongin.ac.kr.
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Ji
mesh_terms: D000818:Animals; D001141:Aromatase / Q000235:genetics; D017609:Barium Compounds / Q000633:toxicity*; D002712:Chlorides / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D052244:Endocrine Disruptors / Q000633:toxicity*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006066:Gonads / Q000187:drug effects* / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D012098:Reproduction / Q000187:drug effects*; D012737:Sex Factors; D014158:Transcription, Genetic / Q000187:drug effects; D015027:Zebrafish / Q000235:genetics / Q000378:metabolism; D029961:Zebrafish Proteins / Q000235:genetics
chemical_list: D017609:Barium Compounds; D002712:Chlorides; D052244:Endocrine Disruptors; D012739:Gonadal Steroid Hormones; D029961:Zebrafish Proteins; C024986:barium chloride; D001141:Aromatase; C440729:Cyp19a1a protein, zebrafish
keywords: Barium chloride; Endocrine disruption; HPG axis; Reproduction; Zebrafish