title: Decrease of the insulin-like growth factor-1 bioavailability in spontaneously hypertensive rats with erectile dysfunction.
abstract: We investigated the role of insulin-like growth factor-1 (IGF-1) in spontaneously hypertensive rats with erectile dysfunction. Firstly, we evaluated intracavernous pressure. The bioavailability of IGF-1 at both mRNA and protein levels were measured by quantitative real-time PCR and Western blot respectively. Then, cavernous cyclic guanosine monophosphate concentrations were detected by enzyme-linked immunosorbent assay. The cavernosal pressure was significantly decreased in the hypertensive and the propranolol treatment groups compared to the normal control group (P < 0.01). Cavernous IGF-1 bioavailability and the concentrations of cavernous cyclic guanosine monophosphate were both significantly decreased in the hypertensive and the propranolol treatment groups compared to the normal control group (P < 0.01). This study suggests that an obvious decrease in cavernous IGF-1 levels might play an important role in spontaneously hypertensive rats with erectile dysfunction.
authors.affiliation: Department of Urology, First Affiliated Hospital of Yangtze University, Jingzhou, HuBei, China.
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Zhou
authors.affiliation: Department of Urology, First Affiliated Hospital of Yangtze University, Jingzhou, HuBei, China.
authors.forename: S-P
authors.initials: SP
authors.lastname: Cheng
authors.affiliation: Department of Urology, First Affiliated Hospital of Yangtze University, Jingzhou, HuBei, China.
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Urology, First Affiliated Hospital of Yangtze University, Jingzhou, HuBei, China.
authors.forename: Y-L
authors.initials: YL
authors.lastname: Sun
authors.affiliation: Department of Urology, First Affiliated Hospital of Yangtze University, Jingzhou, HuBei, China.
authors.forename: S
authors.initials: S
authors.lastname: Xiao
authors.affiliation: Department of Urology, First Affiliated Hospital of Yangtze University, Jingzhou, HuBei, China.
authors.forename: R-H
authors.initials: RH
authors.lastname: Liu
authors.affiliation: Department of Urology, First Affiliated Hospital of Yangtze University, Jingzhou, HuBei, China.
authors.forename: F-J
authors.initials: FJ
authors.lastname: Mao
authors.affiliation: Department of Urology, First Affiliated Hospital of Yangtze University, Jingzhou, HuBei, China.
authors.forename: G-J
authors.initials: GJ
authors.lastname: Zhong
authors.affiliation: Department of Urology, First Affiliated Hospital of Yangtze University, Jingzhou, HuBei, China.
authors.forename: J-B
authors.initials: JB
authors.lastname: Huang
authors.affiliation: Department of Urology, First Affiliated Hospital of Yangtze University, Jingzhou, HuBei, China.
authors.forename: H
authors.initials: H
authors.lastname: Pan
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D015153:Blotting, Western; D006152:Cyclic GMP; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D007172:Erectile Dysfunction / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D010413:Penis / Q000378:metabolism / Q000502:physiology*; D011433:Propranolol / Q000627:therapeutic use; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D000959:Antihypertensive Agents; D012333:RNA, Messenger; C548904:insulin-like growth factor-1, rat; D007334:Insulin-Like Growth Factor I; D011433:Propranolol; D006152:Cyclic GMP
keywords: Erectile dysfunction; insulin-like growth factor-1; spontaneously hypertensive rats