title: Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition.
abstract: Phosphodiesterase type 5 inhibitors (PDE5-Is) have recently emerged as a potential therapeutic strategy for neuroinflammatory, neurodegenerative, and memory loss diseases. Mechanistically, PDE5-Is produce an anti-inflammatory and neuroprotection effect by increasing expression of nitric oxide synthases and accumulation of cGMP and activating protein kinase G (PKG), the signaling pathway of which is thought to play an important role in the development of several neurodiseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The aim of this paper was to review present knowledge of the signaling pathways that underlie the use of PDE5-Is in neuroinflammation, neurogenesis, learning, and memory.
authors.affiliation: Laboratório de Ultraestrutura, Centro de Pesquisa Aggeu Magalhães (FIOCRUZ), 50.740-465 Recife, PE, Brazil.
authors.forename: Christina Alves
authors.initials: CA
authors.lastname: Peixoto
authors.affiliation: Laboratório de Ultraestrutura, Centro de Pesquisa Aggeu Magalhães (FIOCRUZ), 50.740-465 Recife, PE, Brazil; Universidade Federal de Pernambuco, 50.670-901 Recife, PE, Brazil.
authors.forename: Ana Karolina Santana
authors.initials: AK
authors.lastname: Nunes
authors.affiliation: Neurobiology of Alzheimer's disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Garcia-Osta
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D051379:Mice; D009410:Nerve Degeneration / Q000188:drug therapy* / Q000503:physiopathology; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology; D009457:Neuroglia / Q000187:drug effects; D015213:Neuroimmunomodulation / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology; D009712:Nucleotides, Cyclic / Q000378:metabolism; D058986:Phosphodiesterase 5 Inhibitors / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D018696:Neuroprotective Agents; D009712:Nucleotides, Cyclic; D058986:Phosphodiesterase 5 Inhibitors