title: Assessment of Background Parenchymal Enhancement and Lesion Kinetics in Breast MRI of BRCA 1/2 Mutation Carriers Compared to Matched Controls Using Quantitative Kinetic Analysis.
abstract: OBJECTIVE
  To investigate whether quantitative kinetic analysis of lesions and background parenchyma in breast magnetic resonance imaging can elucidate differences between BRCA carriers and sporadic controls with high risk for breast cancer.
  
  
  METHODS
  Fifty-nine BRCA and 59 control cases (49 benign, 10 malignant) were examined in this study. Principal component analysis was applied for quantitative analysis of dynamic signal in background parenchyma (B) and lesion (L) in terms of initial enhancement ratio (IER) and delayed enhancement ratio (DER).
  
  
  RESULTS
  Control B-IER, B-DER, L-IER, and L-DER were higher than BRCA cases in all women and in women with benign lesions; statistically significant differences in B-IER and B-DER (all women: P = 0.02 and P = 0.02, respectively; benign only: P = 0.005 and P = 0.005, respectively). In the control cohort, B-IER and B-DER were higher in the premenopausal women than in the postmenopausal women (P = 0.013 and 0.003, respectively), but not in the BRCA cohort; this led to significant differences in B-IER and B-DER between the control and the BRCA groups in the premenopausal women (P = 0.01 and 0.01, respectively) but not in the postmenopausal women.
  
  
  CONCLUSIONS
  Results suggest possible differences in the vascular properties of background parenchyma between BRCA carriers and noncarriers and its association with menopausal status.
authors.affiliation: Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016. Electronic address: Alana.Amarosa@nyumc.org.
authors.forename: Alana A
authors.initials: AA
authors.lastname: Lewin
authors.affiliation: Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016.
authors.forename: Sungheon Gene
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016.
authors.forename: James S
authors.initials: JS
authors.lastname: Babb
authors.affiliation: Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016.
authors.forename: Amy N
authors.initials: AN
authors.lastname: Melsaether
authors.affiliation: Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016.
authors.forename: Jason
authors.initials: J
authors.lastname: McKellop
authors.affiliation: New York University Cancer Institute, 160 East 34th Street 2nd floor, New York, New York 10016.
authors.forename: Melanie
authors.initials: M
authors.lastname: Moccaldi
authors.affiliation: Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016; Department of Radiology, Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Klautau Leite
authors.affiliation: Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016.
authors.forename: Linda
authors.initials: L
authors.lastname: Moy
mesh_terms: D000328:Adult; D000368:Aged; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001706:Biopsy / Q000379:methods; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D016022:Case-Control Studies; D015331:Cohort Studies; D003287:Contrast Media; D005260:Female; D006579:Heterozygote; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007700:Kinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D017698:Postmenopause; D017697:Premenopause; D012189:Retrospective Studies
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D003287:Contrast Media
keywords: BRCA 1/2 mutation carrier; background parenchymal enhancement (BPE); dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI); principal component analysis (PCA)