title: Buprenorphine--the unique opioid adjuvant in regional anesthesia.
abstract: Regional anesthesia techniques are commonly used for many surgical procedures alone or as an addition to general anesthesia, because they offer many advantages over general anesthesia. Unfortunately these techniques are partially limited by the time of action of local anesthetics. One of the methods of overcoming this limitation is adding to the local anesthetic solution additional drug--so called adjuvant. Among many adjuvants to local anesthetic drugs tested so far one seems to be particularly interesting--buprenorphine. The aim of this paper is to present pharmacological background for using buprenorphine for regional anesthesia and to review clinical trials of using buprenorphine for all regional anesthesia techniques: spinal and epidural anesthesia, peripheral nerves blocks, local anesthesia and intravenous regional anesthesia.
authors.affiliation: a Department of Anesthesiology and Intensive Therapy, Faculty of Medicine with the Division of Dentistry and Division of Medical Education in English , Medical University of Białystok , Białystok , Poland.
authors.forename: Juliusz
authors.initials: J
authors.lastname: Kosel
authors.affiliation: a Department of Anesthesiology and Intensive Therapy, Faculty of Medicine with the Division of Dentistry and Division of Medical Education in English , Medical University of Białystok , Białystok , Poland.|b Department of Human Anatomy, Faculty of Medicine with the Division of Dentistry and Division of Medical Education in English , Medical University of Białystok , Białystok , Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Bobik
authors.affiliation: c Department of Pharmacognosy, Faculty of Pharmacy with the Division of Laboratory Medicine , Medical University of Białystok , Białystok , Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Tomczyk
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000765:Anesthesia, Conduction / Q000379:methods*; D000768:Anesthesia, General / Q000379:methods; D000779:Anesthetics, Local / Q000008:administration & dosage; D000818:Animals; D002047:Buprenorphine / Q000008:administration & dosage*; D006801:Humans
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D002047:Buprenorphine
keywords: Buprenorphine; chronic pain syndrome; epidural anesthesia; peripheral nerve block; regional anesthesia; spinal anesthesia