title: Distinguishing rotamers in N-trifluoroacetyl-3-benzazepine derivatives.
abstract: This paper provides the full (13) C NMR assignments for the trifluoroacetamides of five potentially appetite-reducing 5-HT2C benzazepine receptor agonists and two open-ring synthetic precursors. These compounds exist in solution as mixtures of two rotamers for each of which the (13) C NMR signals have now been assigned with the assistance of 2D NMR experiments and the carbonyl-induced shifts of the neighboring (13) CH2 resonances and long-range (13) C/(19) F couplings.
authors.affiliation: Department of Chemistry, Faculty of Sciences, University of Chile, Santiago, Chile.
authors.forename: Williams A
authors.initials: WA
authors.lastname: Acevedo-Fuentes
authors.affiliation: Department of Chemistry, Faculty of Sciences, University of Chile, Santiago, Chile.
authors.forename: Bruce K
authors.initials: BK
authors.lastname: Cassels
mesh_terms: D001067:Appetite Depressants / Q000737:chemistry*; D001552:Benzazepines / Q000737:chemistry*; D002247:Carbon Isotopes; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D005461:Fluorine / Q000737:chemistry; D007536:Isomerism; D010084:Oxidation-Reduction; D011985:Receptors, Serotonin / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D001067:Appetite Depressants; D001552:Benzazepines; D002247:Carbon Isotopes; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C078730:serotonin 5 receptor; D005461:Fluorine