title: A CMOS Amperometric System for Multi-Neurotransmitter Detection.
abstract: In vivo multi-target and selective concentration monitoring of neurotransmitters can help to unravel the brain chemical complex signaling interplay. This paper presents a dedicated integrated potentiostat transducer circuit and its selective electrode interface. A custom 2-electrode time-based potentiostat circuit was fabricated with 0.13 μm CMOS technology and provides a wide dynamic input current range of 20 pA to 600 nA with 56 μ W, for a minimum sampling frequency of 1.25 kHz. A multi-working electrode chip is functionalized with carbon nanotubes (CNT)-based chemical coatings that offer high sensitivity and selectivity towards electroactive dopamine and non-electroactive glutamate. The prototype was experimentally tested with different concentrations levels of both neurotransmitter types, and results were similar to measurements with a commercially available potentiostat. This paper validates the functionality of the proposed biosensor, and demonstrates its potential for the selective detection of a large number of neurochemicals.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Massicotte
authors.forename: Sandro
authors.initials: S
authors.lastname: Carrara
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Micheli
authors.forename: Mohamad
authors.initials: M
authors.lastname: Sawan
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D055664:Electrochemical Techniques / Q000379:methods; D006801:Humans; D008839:Microelectrodes; D037742:Nanotubes, Carbon / Q000737:chemistry; D009420:Nervous System / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon