title: Histopathologic and metabolic effect of ursodeoxycholic acid treatment on PCOS rat model.
abstract: The aim of this study was to determine the effect of ursodeoxycholic acid (UDCA) treatment on a polycystic ovary syndrome (PCOS) rat model. Thirty-two female Wistar-Albino rats were randomly divided into four groups as follows - group 1: sham group (n: 8), group 2: letrozole-induced PCOS group (n: 8), group 3: letrozole-induced PCOS plus metformin-treated (500 mg/kg) group (n: 8) and group 4: letrozole-induced PCOS plus UDCA (150 mg/kg)-treated group (n: 8). Histopathologic examination of the ovaries, circulating estrone (E1), estradiol (E2), testosterone, androstenedione, glucose, insulin and lipid profiles were evaluated. Histopathologic examination results revealed that groups 3 and 4 had significantly lower cystic and atretic follicles compared to group 2. Besides, group 4 had significantly higher antral follicles than group 2 (8.5 ± 2.9 versus 5.4 ± 1.1; p: 0.001). Furthermore, total testosterone (4.9 ± 2.8 versus 8.8 ± 2.9; p= 0.004) and insulin levels were significantly lower in group 4 compared to group 2 (1.7 ± 0.08 versus 2.1 ± 0.5; p = 0.02). However, lipid parameters, E1, E2, glucose and HOMA-IR were comparable between the groups. Our study results demonstrated that UDCA therapy improves ovarian morphology and decreases total testosterone and insulin levels.
authors.affiliation: a Department of Obstetric and Gynecology , School of Medicine, Mustafa Kemal University , Hatay , Turkey .
authors.forename: Ilay
authors.initials: I
authors.lastname: Gozukara
authors.affiliation: b Department of Physiology , Mustafa Kemal University , Hatay , Turkey .
authors.forename: Recep
authors.initials: R
authors.lastname: Dokuyucu
authors.affiliation: c Department of Pathology , Mustafa Kemal University , Hatay , Turkey .
authors.forename: Tümay
authors.initials: T
authors.lastname: Özgür
authors.affiliation: d Department of Biochemistry , Mustafa Kemal University , Hatay , Turkey .
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Özcan
authors.affiliation: e Department of Pharmacology , Mustafa Kemal University , Hatay , Turkey , and.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Pınar
authors.affiliation: a Department of Obstetric and Gynecology , School of Medicine, Mustafa Kemal University , Hatay , Turkey .
authors.forename: Raziye Keskin
authors.initials: RK
authors.lastname: Kurt
authors.affiliation: f Department of Obstetric and Gynecology , Dumlupinar University, School of Medicine , Kütahya , Turkey.
authors.forename: Suna Kabil
authors.initials: SK
authors.lastname: Kucur
authors.affiliation: a Department of Obstetric and Gynecology , School of Medicine, Mustafa Kemal University , Hatay , Turkey .
authors.forename: Kenan
authors.initials: K
authors.lastname: Dolapcioglu
mesh_terms: D000818:Animals; D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D010053:Ovary / Q000187:drug effects*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid
keywords: Histopathology; polycystic ovary syndrome; treatment; ursodeoxycholic acid