title: Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration.
abstract: The regeneration of cartilage, an aneural and avascular tissue, is often compromised by its lack of innate abilities to mount a sufficient healing response. Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes. The previous in vitro study showed that kartogenin also had a chondrogenesis effect on synovium derived mesenchymal stem cells (SMSCs). Herein, we present the effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology. In vivo studies showed its potential role for cell homing, especially for recruiting the host's endogenous cells, including BMSCs and SMSCs, without cell transplantation. Of note, the regenerated tissues were close to the natural hyaline cartilage based on the histological tests, specific markers analysis, and biomechanical tests. This innovative KGN release system makes the chondrogenesis efficient and persistent.
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University , Zhongshan Road 321, Nanjing 210008, Jiangsu China.
authors.forename: Dongquan
authors.initials: D
authors.lastname: Shi
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University , Zhongshan Road 321, Nanjing 210008, Jiangsu China.
authors.forename: Xingquan
authors.initials: X
authors.lastname: Xu
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
authors.forename: Yanqi
authors.initials: Y
authors.lastname: Ye
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University , Zhongshan Road 321, Nanjing 210008, Jiangsu China.
authors.forename: Kai
authors.initials: K
authors.lastname: Song
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
authors.forename: Jin
authors.initials: J
authors.lastname: Di
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
authors.forename: Quanyin
authors.initials: Q
authors.lastname: Hu
authors.forename: Jianxin
authors.initials: J
authors.lastname: Li
authors.forename: Huangxian
authors.initials: H
authors.lastname: Ju
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University , Zhongshan Road 321, Nanjing 210008, Jiangsu China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.|Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.|Department of Medicine, University of North Carolina School of Medicine , Chapel Hill, North Carolina 27599, United States.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
keywords: drug delivery; hydrogel; nanoparticles; regenerative medicine; tissue engineering