title: [C1Q NEPHROPATHY: CASE REPORTS AND LITERATURE REVIEW].
abstract: C1q nephropathy is considered a form of glomerulonephritis, defined by histological findings of dominant Clq immune deposits in renal biopsy. It is a rare disease, most often manifested in children and young adults. The most common clinical manifestation of the disease is nephrotic syndrome, but other renal syndromes could also be found. The cause of the disease is not known, but the immune pathogenesis could be assumed. Often, resistance to glucocorticoid or other immunosuppressive therapy is present, potentially leading to chronic renal insufficiency. We present ten patients with renal biopsy and clinical findings of Clq nephropathy. None of the patients had clinical or serological manifestations of systemic lupus. All patients had normal findings of C3 and C4 components of complement, as well as normal ANF, anti-dsD-NA and ANCA antibodies.
authors.forename: Krešimir
authors.initials: K
authors.lastname: Galešić
authors.forename: Ivica
authors.initials: I
authors.lastname: Horvatić
authors.forename: Danica
authors.initials: D
authors.lastname: Batinić
authors.forename: Danko
authors.initials: D
authors.lastname: Milošević
authors.forename: Marijan
authors.initials: M
authors.lastname: Saraga
authors.forename: Merica Glavina
authors.initials: MG
authors.lastname: Durdov
authors.forename: Danica Galešić
authors.initials: DG
authors.lastname: Ljubanović
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015922:Complement C1q / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D015922:Complement C1q