title: Pharmacokinetics of ambroxol and clenbuterol tablets in healthy Chinese volunteers.
abstract: OBJECTIVE
  To investigate the pharmacokinetics of Ambroxol and Clenbuterol Tablets in Chinese healthy volunteers after a single or multiple dosages oral administration.
  
  
  METHODS
  A total of 9 healthy adult subjects were given Ambroxol and Clenbuterol Tablets in a single dosage or multiple dosages respectively. LC/MS/MS were used for the determination of Ambroxol and Clenbuterol of in plasma. The important pharmacokinetic parameters were calculated by DAS 2.0 software (compartment model).
  
  
  RESULTS
  Single and multiple dosage groups of Ambroxol and Clenbuterol were all fitted two-compartment model. The pharmacokinetics fitted first order kinetics process. No difference in pharmacokinetics of Ambroxol in single and multiple dosage groups volunteers was observed, Which showed no marked changes, suggesting that multiple dosing did not influence the velocity of drug metabolism. Moreover, parameters of Clenbuterol had significant difference between the single and multiple dosage groups (P<0.05), showing there was accumulation in the body. 9 subjects had completed single or multiple dosages oral administration test, with no adverse drug reactions appeared during the test.
  
  
  CONCLUSIONS
  There was no obvious accumulation of Ambroxol after repeated dosing. But obvious accumulation of Clenbuterol was noted in multiple-dose administration. The established method is sensitive, accurate, reliable and specific, and it can meet the requirement of clinical pharmacokinetic trial.
authors.affiliation: Department of Pharmacy, Beijing Military Region General Hospital Beijing, China.
authors.forename: Yong-Ge
authors.initials: YG
authors.lastname: Yang
authors.affiliation: Department of Pharmacy, Beijing Military Region General Hospital Beijing, China.
authors.forename: Li-Xue
authors.initials: LX
authors.lastname: Song
authors.affiliation: Department of Pharmacy, Beijing Military Region General Hospital Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Department of Pharmacy, Beijing Military Region General Hospital Beijing, China.
authors.forename: Xue-Ting
authors.initials: XT
authors.lastname: Xu
authors.affiliation: Department of Pharmacy, Beijing Military Region General Hospital Beijing, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Di
authors.affiliation: Department of Pharmacy, Beijing Military Region General Hospital Beijing, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
keywords: Ambroxol; LC/MS/MS; clenbuterol; pharmacokinetics