title: Relationship between high sensitivity troponins and estimated glomerular filtration rate.
abstract: BACKGROUND
  Diagnosis of acute coronary syndrome may be challenging because of high troponin concentrations in patients with chronic kidney disease.
  
  
  OBJECTIVE
  the aim of this study is to investigate the difference between high sensitivity troponin T and troponin I in four groups of patients separated according to eGFR values and the effect of renal function both on troponin T and troponin I.
  
  
  METHODS
  119 outpatients were divided into 4 groups according to their eGFR values as Group 1: eGFR<30, Group 2: eGFR between 30 and 60, Group 3: eGFR between 60 and 90 and Group 4: eGFR >90mL/min/1.73m(2). The cardiac troponin T and I concentrations were measured concurrently.
  
  
  RESULTS
  Troponin T values of all patients who have eGFR values lower than 30mL/min/1.73m(2) were above the decision point, but cTnI values of only 2 patients were above the decision limit (40ng/L) in this group. There was a strong and significant negative relationship between eGFR and hs-cTnT [log(y)=2.3-0.72log(x); R(2)=0.625] whereas there was no significant relationship between eGFR and hs-cTnI [log(y)=1.28-0.08log(x); R(2)=0.013] when eGFR was taken into consideration as a continuous variable.
  
  
  CONCLUSIONS
  In this study, we found that cTnT increases with decreasing eGFR values, but cTnI is not affected by the change in eGFR values.
authors.affiliation: Department of Medical Biochemistry, Ankara Training and Research Hospital, Ministry of Health, Ankara 06340, Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Guclu
authors.affiliation: Department of Medical Biochemistry, Ankara Training and Research Hospital, Ministry of Health, Ankara 06340, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Bolat
authors.affiliation: Department of Medical Biochemistry, Ankara Training and Research Hospital, Ministry of Health, Ankara 06340, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Şenes
authors.affiliation: Department of Medical Biochemistry, Ankara Training and Research Hospital, Ministry of Health, Ankara 06340, Turkey. Electronic address: doyucel@yahoo.com.
authors.forename: Dogan
authors.initials: D
authors.lastname: Yucel
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D005919:Glomerular Filtration Rate; D006801:Humans; D008875:Middle Aged; D012680:Sensitivity and Specificity; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D019210:Troponin I; D020107:Troponin T
keywords: Acute coronary syndrome; Cardiac troponin; Chronic kidney disease; Creatinine; Estimated glomerular filtration rate