title: One-Pot Synthesis of Multisubstituted Benzimidazoles via Sequential Ugi and Catalytic Aza-Wittig Reaction Starting from 2-Aminobenzoyl Azides.
abstract: A simple and one-pot synthesis of multisubstituted benzimidazoles by a Ugi 4CC/catalytic aza-Wittig sequence was developed. The reaction of 2-aminobenzoyl azide 2, aldehyde 3, acid 4, and isocyanide 5 produced the benzimidazoles 8 in moderate to good yields via a sequential Ugi condensation and catalytic aza-Wittig in the presence of a catalytic amount of phospholene oxide.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University , Wuhan 430079, P. R. China.
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Yan
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University , Wuhan 430079, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Rao
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University , Wuhan 430079, P. R. China.
authors.forename: Ming-Wu
authors.initials: MW
authors.lastname: Ding