title: Self-Disorders and Clinical High Risk for Psychosis: An Empirical Study in Help-Seeking Youth Attending Community Mental Health Facilities.
abstract: Anomalous subjective experiences involving an alteration of the basic sense of self (ie, Self-disorder [SD]) are emerging as a core marker of schizophrenia spectrum disorders with potential impact on current early detection strategies as well. In this study, we wished to field-test the prevalence of SD in a clinical sample of adolescent/young adult help-seekers at putative risk for psychosis attending standard community mental health facilities in Italy. Participants (n = 47), aged between 14 and 25, underwent extensive psychopathological evaluations with current semi-structured tools to assess Clinical High Risk (CHR) state (ie, Structured Interview for Prodromal Syndromes/Scale of Prodromal Symptoms [SIPS/SOPS], Schizophrenia Proneness Instrument-Adult/Child and Youth [SPI-A/CY]). SD aggregated in CHR subjects as compared to the non-CHR and revealed substantial association with sub-psychotic symptoms (SIPS), subjective experience of cognitive and cognitive-perceptual vulnerability (basic symptoms) and functional level (Global Assessment of functioning). Moreover, a combination of the 2 approaches (ie, CHR plus SD) enabled further "closing-in" on a subgroup of CHR with lower global functioning. The results confirm SD's relevance for the early profiling of youths at potential high risk for psychosis.
authors.affiliation: NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, and Diakonhjemmet Hospital, Oslo, Norway; andrea.raballo@medisin.uio.no.
authors.forename: Andrea
authors.initials: A
authors.lastname: Raballo
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy; Department of Mental Health, Viterbo Health Trust, Viterbo, Italy;
authors.forename: Elena
authors.initials: E
authors.lastname: Pappagallo
authors.affiliation: Department of Mental Health, Viterbo Health Trust, Viterbo, Italy;
authors.forename: Alice
authors.initials: A
authors.lastname: Dell' Erba
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy; Department of Neuroscience, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy;
authors.forename: Nella
authors.initials: N
authors.lastname: Lo Cascio
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy;
authors.forename: Martina
authors.initials: M
authors.lastname: Patane'
authors.affiliation: Neurosciences, Mental Health and Sensory Functions (NESMOS) Department, Faculty of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy;
authors.forename: Eva
authors.initials: E
authors.lastname: Gebhardt
authors.affiliation: Department of Mental Health, Rome E Health Trust, Rome, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Boldrini
authors.affiliation: Department of Mental Health, Viterbo Health Trust, Viterbo, Italy;
authors.forename: Laura
authors.initials: L
authors.lastname: Terzariol
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy;
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Angelone
authors.affiliation: Department of Mental Health, Viterbo Health Trust, Viterbo, Italy;
authors.forename: Alberto
authors.initials: A
authors.lastname: Trisolini
authors.affiliation: Neurosciences, Mental Health and Sensory Functions (NESMOS) Department, Faculty of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy;
authors.forename: Paolo
authors.initials: P
authors.lastname: Girardi
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy;
authors.forename: Paolo
authors.initials: P
authors.lastname: Fiori Nastro
mesh_terms: D000293:Adolescent; D000328:Adult; D003156:Community Mental Health Services; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000503:physiopathology*; D010342:Patient Acceptance of Health Care; D010468:Perceptual Disorders / Q000209:etiology / Q000503:physiopathology*; D062706:Prodromal Symptoms; D011618:Psychotic Disorders / Q000150:complications / Q000503:physiopathology*; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*; D055815:Young Adult
keywords: basic symptoms; clinical high risk; positive symptoms; prodrome; psychosis; self; subjective experience