title: A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.
abstract: A novel complex, [Cu(acetylethTSC)Cl]Cl•0.25C2H5OH1(where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines.In vitrostudies showed that complex1acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects.
authors.affiliation: Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, U.S.A.
authors.forename: Shayna
authors.initials: S
authors.lastname: Sandhaus
authors.affiliation: Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Drive #5043, Hattiesburg, MS, 39406, U.S.A.
authors.forename: Rosella
authors.initials: R
authors.lastname: Taylor
authors.affiliation: Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Drive #5043, Hattiesburg, MS, 39406, U.S.A.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Edwards
authors.affiliation: Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Drive #5043, Hattiesburg, MS, 39406, U.S.A.
authors.forename: Alexis
authors.initials: A
authors.lastname: Huddleston
authors.affiliation: Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Drive #5043, Hattiesburg, MS, 39406, U.S.A.
authors.forename: Ykeysha
authors.initials: Y
authors.lastname: Wooten
authors.affiliation: Department of Chemistry and Biochemistry, P.O. Box 17910, 1400 JR Lynch Street, Jackson State University, Jackson, MS 39217, U.S.A.
authors.forename: Ramaiyer
authors.initials: R
authors.lastname: Venkatraman
authors.affiliation: EPR Division Bruker BioSpin, 44 Manning Road, Billerica, MA 01821, U.S.A.
authors.forename: Ralph T
authors.initials: RT
authors.lastname: Weber
authors.affiliation: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, U.S.A.
authors.forename: Antonio
authors.initials: A
authors.lastname: González-Sarrías
authors.affiliation: North Carolina A and T State University, Department of Biology, Hines Hall, Room 300-B, 1601 East Market St., Greensboro, NC 27411, U.S.A.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Martin
authors.affiliation: North Carolina A and T State University, Department of Biology, Hines Hall, Room 300-B, 1601 East Market St., Greensboro, NC 27411, U.S.A.
authors.forename: Patrice
authors.initials: P
authors.lastname: Cagle
authors.affiliation: Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, U.S.A; Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, U.S.A.
authors.forename: Yuk-Ching
authors.initials: YC
authors.lastname: Tse-Dinh
authors.affiliation: Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, U.S.A.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Beebe
authors.affiliation: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, U.S.A.
authors.forename: Navindra
authors.initials: N
authors.lastname: Seeram
authors.affiliation: Department of Chemistry and Biochemistry, Old Dominion University, 4541 Hampton Boulevard, Norfolk, VA 23529, U.S.A.
authors.forename: Alvin A
authors.initials: AA
authors.lastname: Holder
keywords: ESR spectroscopy; breast cancer; copper(II); cyclic voltammetry; human topoisomerase Iiα; thiosemicarbazones