title: Respiratory and lower limb muscle function in interstitial lung disease.
abstract: Growing evidence suggests that respiratory and limb muscle function may be impaired in patients with interstitial lung disease (ILD). Importantly, muscle dysfunction could promote dyspnoea, fatigue and functional limitation all of which are cardinal features of ILD. This article examines the risk factors for skeletal muscle dysfunction in ILD, reviews the current evidence on overall respiratory and limb muscle function and focuses on the occurrence and implications of skeletal muscle dysfunction in ILD. Research limitations and pathways to address the current knowledge gaps are highlighted.
authors.affiliation: Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK mariopanag@gmail.com.
authors.forename: Marios
authors.initials: M
authors.lastname: Panagiotou
authors.affiliation: Hygeia General Hospital, Athens, Greece.
authors.forename: Vlasis
authors.initials: V
authors.lastname: Polychronopoulos
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Charlie
authors.initials: C
authors.lastname: Strange
mesh_terms: D004417:Dyspnea / Q000503:physiopathology*; D006801:Humans; D035002:Lower Extremity; D017563:Lung Diseases, Interstitial / Q000503:physiopathology*; D018763:Muscle Fatigue; D018482:Muscle, Skeletal / Q000503:physiopathology; D052097:Quadriceps Muscle / Q000503:physiopathology*; D012132:Respiratory Muscles / Q000503:physiopathology*; D012307:Risk Factors
keywords: Interstitial lung disease; muscle dysfunction; respiratory muscles; risk factors; skeletal muscle