title: When Less Is Better: ER Stress and Beta Cell Proliferation.
abstract: Pancreatic β cells synthesize and secrete insulin to increase anabolic metabolism in an organism, and insulin synthesis has long been suspected to inhibit β cell replication. Recently in Cell Metabolism, Szabat et al. (2015) present evidence that deletion of Insulin genes alleviates ER stress and promotes mature β cell replication.
authors.affiliation: Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Yong
authors.affiliation: Development and Aging Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Pamela
authors.initials: P
authors.lastname: Itkin-Ansari
authors.affiliation: Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: rkaufman@sbpdiscovery.org.
authors.forename: Randal J
authors.initials: RJ
authors.lastname: Kaufman
mesh_terms: D017209:Apoptosis / Q000235:genetics; D002454:Cell Differentiation; D049109:Cell Proliferation; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000378:metabolism*
chemical_list: D007328:Insulin