title: A New Approach for the Synthesis of Highly Substituted Aromatic Rings: The Alkyne-Mediated Approach.
abstract: Pentasubstituted aromatic rings serve as templates for drug design and can be conveniently prepared by the thermolysis of suitably substituted alkynes under microwave conditions.
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK. p.parsons@imperial.ac.uk.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Parsons
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Jones
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK.
authors.forename: Alex C
authors.initials: AC
authors.lastname: Padgham
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK.
authors.forename: Lewis A T
authors.initials: LA
authors.lastname: Allen
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK.
authors.forename: Clive S
authors.initials: CS
authors.lastname: Penkett
authors.affiliation: School of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Green
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK.
authors.forename: Andrew J P
authors.initials: AJ
authors.lastname: White
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015195:Drug Design; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D006841:Hydrocarbons, Aromatic
keywords: alkynes; aromatic rings; cyclization; furan; microwave chemistry; thermolysis