title: Oxidative stress influence on renal dysfunction in patients with obstructive jaundice: A case and control prospective study.
abstract: Obstructive Jaundice (OJ) is associated with a significant risk of developing acute renal failure (ARF). The involvement of oxidative stress in the development of cholestasis has been demonstrated in different experimental models. However, its role in the morbidity of human cholestasis is far to be elucidated. The aim of the study was the evaluation of oxidative stress markers in blood from patients with OJ and its relation to complications and benign/malignant evolution of cholestasis.
  
  
  
  A prospective cross-sectional study of 105 patients with OJ and 34 control subjects were included. Several markers of liver function and oxidative stress, such as lipoperoxides (LPO), as well as reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were assessed.
  
  
  
  The patients with OJ showed a marked increase in plasma levels of LPO, SOD and GSH, while GSH-Px levels were decreased. The increase in lipid peroxidation products and the depletion of SOD activity in blood were also related to renal dysfunction. The highest level of LPO was associated with malignant etiology of the disease. The logistic regression analysis showed that the age of the patient and the levels of LPO in blood were predictors of renal dysfunction in OJ patients.
  
  
  
  This study demonstrates a correlation between oxidative stress and renal dysfunction patients with OJ.
authors.affiliation: General and Digestive Surgery Service, Complejo Hospitalario de Toledo, Av de Barber, 30, 45071 Toledo, Spain. Electronic address: cordcuen@hotmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Martínez-Cecilia
authors.affiliation: Department of General Surgery, Hospital Universitario Virgen del Rocio, Sevilla, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Reyes-Díaz
authors.affiliation: General and Digestive Surgery Service, Hospital Universitario Reina Sofía, Cordoba, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Ruiz-Rabelo
authors.affiliation: General and Digestive Surgery Service, Hospital Universitario Reina Sofía, Cordoba, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Gomez-Alvarez
authors.affiliation: Statistics and Research Service, Hospital Universitario Reina Sofía, Cordoba, Spain.
authors.forename: Carmen Muñoz
authors.initials: CM
authors.lastname: Villanueva
authors.affiliation: Department of General Surgery, Hospital Universitario Virgen del Rocio, Sevilla, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Álamo
authors.affiliation: Department of General Surgery, Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Muntané
authors.affiliation: Department of General Surgery, Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Padillo
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001663:Bilirubin / Q000097:blood / Q000378:metabolism; D015415:Biomarkers; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D007677:Kidney Function Tests; D015227:Lipid Peroxidation; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers; D001663:Bilirubin
keywords: Acute renal failure; Cancer; Obstructive jaundice; Oxidative stress