title: Effects of a collagen membrane positioned between augmentation material and the sinus mucosa in the elevation of the maxillary sinus floor. An experimental study in sheep.
abstract: OBJECTIVE
  To assess the influence of a collagen membrane placed subjacent to a pristine sinus mucosa on the healing outcome of a sinus floor elevation procedure.
  
  
  METHODS
  Eight Pelibuey sheep (Cubano rojo) underwent sinus floor elevation on both sides of the maxilla. At a randomly selected side (test), a collagen membrane was placed subjacent to the sinus mucosa, while the contralateral side (control) was left without the placement of a membrane. Deproteinized bovine bone mineral (DBBM) was used to fill the space created. A collagen membrane was placed bilaterally to cover the access osteotomy. After 4 months, biopsies were harvested and ground sections prepared. Morphometric analysis was performed in four different regions, three within the elevated area and one at the site of the osteotomy.
  
  
  RESULTS
  The total percentages of mineralized new bone within the elevated area were 29.4 ± 16.2% and 30.9 ± 9.2% and of marrow spaces 44.0 ± 23.0% and 45.6 ± 14.1%, at the Non-membrane and at the Membrane sites, respectively. A low content of connective tissue within the elevated area was noticed. A higher content of connective tissue was found in the osteotomy region, however. Remnants of DBBM granules were found at a percentage of 17-19%. No statistically significant differences were observed between test and control sites.
  
  
  CONCLUSIONS
  The application of a collagen membrane subjacent to the Schneiderian mucosa in a sinus floor elevation procedure did not influence the healing outcomes at all.
authors.affiliation: ARDEC, Ariminum Odontologica, Rimini, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Scala
authors.affiliation: Center for Dental Medicine, University of Zurich, Zurich, Switzerland.|University of Bern, Bern, Switzerland.
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
authors.affiliation: Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
authors.forename: Joaquin Urbizo
authors.initials: JU
authors.lastname: Velez
authors.affiliation: Private Practice, Treviso (TV), Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Favero
authors.affiliation: Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
authors.forename: Franco
authors.initials: F
authors.lastname: Bengazi
authors.affiliation: ARDEC, Ariminum Odontologica, Rimini, Italy. daniele.botticelli@gmail.com.|Faculty of Dentistry, University of Medical Science, La Habana, Cuba. daniele.botticelli@gmail.com.
authors.forename: Daniele
authors.initials: D
authors.lastname: Botticelli
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000494:pharmacology; D003094:Collagen; D008567:Membranes, Artificial; D010012:Osteogenesis / Q000502:physiology*; D010027:Osteotomy; D012756:Sheep; D034561:Sheep, Domestic; D059546:Sinus Floor Augmentation / Q000379:methods*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial; D003094:Collagen
keywords: animal study; bone healing; collagen membrane; deproteinized bovine bone mineral; osteoconductivity morphometry; sinus floor elevation; xenograft