title: An enantioselective three-component reaction of diazoacetates with indoles and enals by iridium/iminium co-catalysis.
abstract: The first example of chiral secondary amine and iridium(i) co-catalyzed enantioselective three-component reaction of aryldiazoacetates, indoles and enals was rationally designed and developed to afford 3-substituted indole derivatives in good yields and with moderate diastereoselectivity as well as excellent enantioselectivity. This reaction is proposed to proceed through the enantioselective trapping of iridium(I)-associated zwitterionic intermediates via selective 1,4-addtition to the chiral amine activated enals.
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China. syliu@sist.ecnu.edu.cn whu@chem.ecnu.edu.cn.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Li
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China. syliu@sist.ecnu.edu.cn whu@chem.ecnu.edu.cn and School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China. syliu@sist.ecnu.edu.cn whu@chem.ecnu.edu.cn.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Jin
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China. syliu@sist.ecnu.edu.cn whu@chem.ecnu.edu.cn.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China. syliu@sist.ecnu.edu.cn whu@chem.ecnu.edu.cn.
authors.forename: Shunying
authors.initials: S
authors.lastname: Liu
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China. syliu@sist.ecnu.edu.cn whu@chem.ecnu.edu.cn.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Hu