title: Meta-analysis indicates that SNP rs9939609 within FTO is not associated with major depressive disorder (MDD) in Asian population.
abstract: BACKGROUND
  Major depressive disorder (MDD) is one of the most prevalent psychiatric illnesses with heritability of up to 38%. The fat mass- and obesity-associated (FTO) gene, in particular the single nucleotide polymorphism (SNP) rs9939609, has been identified as a genetic risk loci associated with MDD. However, most prior studies have involved European and American populations. Whether rs9939609 is an true risk SNP for MDD in Asian populations remains inconclusive.
  
  
  METHODS
  In the present study, we conducted a meta-analysis of the association between rs9939609 and MDD in Asian populations by combining 5 available case-control samples totaling 6531 cases and 12,359 controls.
  
  
  RESULTS
  Our meta-analysis suggests that rs9939609 is not a risk SNP for MDD in Asian populations by fixed effect model (Z=1.04, P=0.30, OR=0.96, 95% CI=0.90-1.03).
  
  
  CONCLUSIONS
  The age distribution and gender ratios were not matched well in the combined samples of cases and controls. Publication bias might be also considered with only a relatively small number of association studies of FTO rs9939609 with MDD in Asian populations.
  
  
  CONCLUSIONS
  The absence of association of rs9939609 with MDD in our Asian populations suggests a potential genetic heterogeneity in the susceptibility of MDD on this locus.
authors.affiliation: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
authors.forename: Yueqiang
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650031, China.
authors.forename: Tingfu
authors.initials: T
authors.lastname: Du
authors.affiliation: Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Sun
authors.affiliation: Mental Health Center, Huaxi Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Deng
authors.affiliation: Disease Epigenetics Group, Murdoch Childrens Research Institute & Department of Paediatrics, University of Melbourne, Parkville 3052, Victoria, Australia; Inserm, U1061, Univ Montpellier, Montpellier, France.
authors.forename: Joanne
authors.initials: J
authors.lastname: Ryan
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. Electronic address: raoshuquantongji@163.com.
authors.forename: Shuquan
authors.initials: S
authors.lastname: Rao
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000208:ethnology* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: Asian population; FTO; Major depressive disorder; Meta-analysis; rs9939609