title: Genetic polymorphisms in MMP 2, 3 and 9 genes and the susceptibility of osteosarcoma in a Chinese Han population.
abstract: BACKGROUND
  There are no data about the role of MMPs polymorphism in development of osteosarcoma.
  
  
  METHODS
  Two-hundred fifty-one patients with osteosarcoma and 251 healthy controls were included to investigate the association between the MMP2, 3, 9 polymorphisms and the risk of osteosarcoma.
  
  
  RESULTS
  Compared with the MMP2 SNP rs243865 homozygote CC, The heterozygous CT genotype was associated with significantly increased risk for osteosarcoma (OR = 1.86, 95% CI = 1.18-4.22, p = 0.014); the TT genotype was associated with increased risk for osteosarcoma (OR = 1.92, 95% CI = 1.21-3.52, p = 0.028). However, the genotype and allele frequencies of MMP3 rs3025058 and MMP9 rs3918242 polymorphisms were not significantly different.
  
  
  CONCLUSIONS
  MMP2 rs243865 genotype was associated with increased risk for development of osteosarcoma in Chinese Han population.
authors.affiliation: a Department of Orthopaedics , The Fourth Affiliated Hospital of China Medical University , Shenyang , Liaoning Province , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cui
authors.affiliation: a Department of Orthopaedics , The Fourth Affiliated Hospital of China Medical University , Shenyang , Liaoning Province , China.
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Zhu
authors.affiliation: a Department of Orthopaedics , The Fourth Affiliated Hospital of China Medical University , Shenyang , Liaoning Province , China.
authors.forename: Cheng-Bin
authors.initials: CB
authors.lastname: Ma
authors.affiliation: a Department of Orthopaedics , The Fourth Affiliated Hospital of China Medical University , Shenyang , Liaoning Province , China.
authors.forename: Kai
authors.initials: K
authors.lastname: Cui
authors.affiliation: a Department of Orthopaedics , The Fourth Affiliated Hospital of China Medical University , Shenyang , Liaoning Province , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: a Department of Orthopaedics , The Fourth Affiliated Hospital of China Medical University , Shenyang , Liaoning Province , China.
authors.forename: Sheng-Hui
authors.initials: SH
authors.lastname: Ni
authors.affiliation: a Department of Orthopaedics , The Fourth Affiliated Hospital of China Medical University , Shenyang , Liaoning Province , China.
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D012516:Osteosarcoma / Q000208:ethnology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
chemical_list: C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9
keywords: MMPs; osteosarcoma; single-nucleotide polymorphism; susceptibility