title: Cassane diterpenes from the seed kernels of Caesalpinia sappan.
abstract: Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CD spectroscopic analysis. Among the isolated compounds, tomocin A, phanginin A, F, and H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions.
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Hai Xuan
authors.initials: HX
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Nhan Trung
authors.initials: NT
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Phu Hoang
authors.initials: PH
authors.lastname: Dang
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Phuoc
authors.initials: P
authors.lastname: Thi Ho
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam. Electronic address: nttmai@hcmus.edu.vn.
authors.forename: Mai Thanh Thi
authors.initials: MTT
authors.lastname: Nguyen
authors.affiliation: Vietnam Military Medical University, Ha Noi, Viet Nam.
authors.forename: Mao
authors.initials: M
authors.lastname: Van Can
authors.affiliation: Division of Natural Drug Discovery, Department of Translational Research, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Dya Fita
authors.initials: DF
authors.lastname: Dibwe
authors.affiliation: Division of Natural Drug Discovery, Department of Translational Research, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Jun-Ya
authors.initials: JY
authors.lastname: Ueda
authors.affiliation: Division of Natural Drug Discovery, Department of Translational Research, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: suresh@inm.u-toyama.ac.jp.
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
mesh_terms: D029911:Caesalpinia / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D012639:Seeds / Q000737:chemistry
chemical_list: D004224:Diterpenes
keywords: Antiausterity agent; Caesalpinia sappan; Caesalpiniaceae; Cassane diterpene; PANC-1