title: Influences of teriparatide administration on marrow fat content in postmenopausal osteopenic women using MR spectroscopy.
abstract: Objective Teriparatide could induce osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. However, there are significant differences between ex vivo and in vivo models. We aimed to evaluate the impact of teriparatide on marrow and abdominal fat accumulation in postmenopausal osteopenic women. Methods Postmenopausal osteopenic women were randomly assigned to receive teriparatide or placebo for 12 months. Subcutaneous (SAT) and visceral adipose tissue (VAT), marrow fat fraction (MFF), bone density (BMD) and bone biomarkers were measured at baseline, 6 and 12 months. Results At 12 months, mean percentage changes in BMD from baseline were 3.51%, 2.21% and 1.80% at lumbar spine, total hip and femoral neck for the teriparatide group, respectively. Relative to baseline conditions, teriparatide reduced MFF (-3.54% at 6 months; -5.87% at 12 months, all p < 0.01). A significant difference in MFF, but not BMD, was first detected at 6 months (p = 0.012) between groups. MFF was negatively associated with SAT (r = -0.479) and positively associated with VAT (r = 0.531) and VAT/SAT (r = 0.415, all p < 0.05). Teriparatide treatment did not alter abdominal fat composition. Conclusion Teriparatide effectively lowers marrow adiposity but not abdominal fat accumulation in postmenopausal osteopenic women.
authors.affiliation: a Department of Radiology , Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China ;|b Department of Radiology , The Second Affiliated Hospital of Soochow University , Suzhou , China ;
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: a Department of Radiology , Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China ;|c Department of Radiology , Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University , Yangzhou , China ;
authors.forename: X
authors.initials: X
authors.lastname: Luo
authors.affiliation: d Department of Radiology , First People's Hospital Affiliated to Shanghai Jiaotong University , Shanghai , China ;
authors.forename: X
authors.initials: X
authors.lastname: Xie
authors.affiliation: a Department of Radiology , Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China ;
authors.forename: F
authors.initials: F
authors.lastname: Yan
authors.affiliation: b Department of Radiology , The Second Affiliated Hospital of Soochow University , Suzhou , China ;
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.affiliation: b Department of Radiology , The Second Affiliated Hospital of Soochow University , Suzhou , China ;
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.affiliation: b Department of Radiology , The Second Affiliated Hospital of Soochow University , Suzhou , China ;
authors.forename: Z
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: e Department of Endocrinology , The Second Affiliated Hospital of Soochow University , Suzhou , China.
authors.forename: C
authors.initials: C
authors.lastname: Fang
authors.affiliation: b Department of Radiology , The Second Affiliated Hospital of Soochow University , Suzhou , China ;
authors.forename: J
authors.initials: J
authors.lastname: Shen
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects / Q000503:physiopathology; D015502:Absorptiometry, Photon; D050154:Adiposity / Q000187:drug effects*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001853:Bone Marrow / Q000737:chemistry / Q000187:drug effects*; D005260:Female; D005272:Femur Neck; D006801:Humans; D008159:Lumbar Vertebrae; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010919:Placebos; D019379:Teriparatide / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D050071:Bone Density Conservation Agents; D010919:Placebos; D019379:Teriparatide
keywords: Marrow adiposity; abdominal fat accumulation; teriparatide