title: The exocyst in Candida albicans polarized secretion and filamentation.
abstract: The exocyst is an octameric complex that orchestrates the docking and tethering of vesicles to the plasma membrane during exocytosis and is fundamental for key biological processes including growth and establishment of cell polarity. Although components of the exocyst are well conserved among fungi, the specific functions of each component of the exocyst complex unique to Candida albicans biology and pathogenesis are not fully understood. This commentary describes recent findings regarding the role of exocyst subunits Sec6 and Sec15 in C. albicans filamentation and virulence.
authors.affiliation: Section of Infectious Diseases, New Mexico VA Healthcare System, 1501 San Pedro SE, Mail Code 111-J, Albuquerque, NM, 87108, USA. albitach@nmsu.edu.|Division of Infectious Diseases, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA. albitach@nmsu.edu.
authors.forename: Alba A
authors.initials: AA
authors.lastname: Chavez-Dozal
authors.affiliation: Section of Infectious Diseases, New Mexico VA Healthcare System, 1501 San Pedro SE, Mail Code 111-J, Albuquerque, NM, 87108, USA.|Division of Infectious Diseases, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA.
authors.forename: Stella M
authors.initials: SM
authors.lastname: Bernardo
authors.affiliation: Section of Infectious Diseases, New Mexico VA Healthcare System, 1501 San Pedro SE, Mail Code 111-J, Albuquerque, NM, 87108, USA.|Division of Infectious Diseases, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA.
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Lee
keywords: Exocyst; Filamentation; Polarisome; SEC15; SEC6; Secretion; Spitzenkörper