title: Roles of Oxidative Stress in Polycystic Ovary Syndrome and Cancers.
abstract: Oxidative stress (OS) has received extensive attention in the last two decades, because of the discovery that abnormal oxidation status was related to patients with chronic diseases, such as diabetes, cardiovascular, polycystic ovary syndrome (PCOS), cancer, and neurological diseases. OS is considered as a potential inducing factor in the pathogenesis of PCOS, which is one of the most common complex endocrine disorders and a leading cause of female infertility, affecting 4%-12% of women in the world, as OS has close interactions with PCOS characteristics, just as insulin resistance (IR), hyperandrogenemia, and chronic inflammation. It has also been shown that DNA mutations and alterations induced by OS are involved in cancer pathogenesis, tumor cell survival, proliferation, invasion, angiogenesis, and so on. Furthermore, recent studies show that the females with PCOS are reported to have an increasing risk of cancers. As a result, the more serious OS in PCOS is regarded as an important potential incentive for the increasing risk of cancers, and this study aims to analyze the possibility and potential pathogenic mechanism of the above process, providing insightful thoughts and evidences for preventing cancer potentially caused by PCOS in clinic.
authors.affiliation: Joint Laboratory of Reproductive Medicine, SCU-CUHK, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Department of Biological and Pharmaceutical Engineering, School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zuo
authors.affiliation: Reproductive Medicine Center, The Second Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610041, China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Joint Laboratory of Reproductive Medicine, SCU-CUHK, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Wenming
authors.initials: W
authors.lastname: Xu
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology*; D018384:Oxidative Stress; D011085:Polycystic Ovary Syndrome / Q000473:pathology*