title: Ravages of Diabetes on Gastrointestinal Sensory-Motor Function: Implications for Pathophysiology and Treatment.
abstract: Symptoms related to functional and sensory abnormalities are frequently encountered in patients with diabetes mellitus. Most symptoms are associated with impaired gastric and intestinal function. In this review, we discuss basic concepts of sensory-motor dysfunction and how they relate to clinical findings and gastrointestinal abnormalities that are commonly seen in diabetes. In addition, we review techniques that are available for investigating the autonomic nervous system, neuroimaging and neurophysiology of sensory-motor function. Such technological advances, while not readily available in the clinical setting, may facilitate stratification and individualization of therapy in diabetic patients in the future. Unraveling the structural, mechanical, and sensory remodeling in diabetes disease is based on a multidisciplinary approach that can bridge the knowledge from a variety of scientific disciplines. The final goal is to increase the understanding of the damage to GI structures and to sensory processing of symptoms, in order to assist clinicians with developing an optimal mechanics based treatment.
authors.affiliation: GIOME and the Key Laboratory for Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China. hag@giome.org.|GIOME, College of Bioengineering, Chongqing University, 83 Shabei Lu, Chongqing, China. hag@giome.org.
authors.forename: Hans
authors.initials: H
authors.lastname: Gregersen
authors.affiliation: Giome Academia, Department of Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Donghua
authors.initials: D
authors.lastname: Liao
authors.affiliation: Faculty of Health Sciences, Aarhus University, Aarhus, Denmark.
authors.forename: Anne Mohr
authors.initials: AM
authors.lastname: Drewes
authors.affiliation: Mech-Sense, Department of Gastroenterology and Hepatology & Clinical Institute, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Asbjørn Mohr
authors.initials: AM
authors.lastname: Drewes
authors.affiliation: Giome Academia, Department of Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Zhao
mesh_terms: D003929:Diabetic Neuropathies / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000502:physiology; D041981:Gastrointestinal Tract / Q000294:innervation* / Q000473:pathology; D006801:Humans; D012678:Sensation Disorders / Q000209:etiology / Q000503:physiopathology
keywords: Diabetes; Dysfunction; Gastrointestinal tract; Mechanosensory; Remodeling