title: A Lanthanum-Tagged Chemotherapeutic Agent HA-Pt to Track theIn VivoDistribution of Hyaluronic Acid Complexes.
abstract: Hyaluronic acid drug conjugates can target anti-cancer drugs directly to tumor tissue for loco-regional treatment with enhanced bioavailability, local efficacy and reduced toxicity. In this study, the distribution and pharmacokinetics of hyaluronic acid carrier and a conjugated cisplatin anti-cancer drug were tracked by lanthanum (III) [La(III)] affinity tagging of the nanocarrier. The strong binding affinity of La(III) to HA enabled the simple preparation of a physiologically stable complex HA-Pt-La and straightforward simultaneous detection of HA-La and Pt in biological matrices using inductively coupled plasma-mass spectrometry (ICP-MS). Consequently, after subcutaneous injection of HA-Pt-La nanoparticles in human head and neck squamous cell carcinoma (HNSCC) tumor-bearing mice, the HA and Pt content were detected and quantified simultaneously in the plasma, primary tumor, liver and spleen.
authors.affiliation: Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.
authors.forename: Ti
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Yang
authors.affiliation: HylaPharm LLC, Lawrence, KS.
authors.forename: W C
authors.initials: WC
authors.lastname: Forrest
authors.affiliation: Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.
authors.forename: Shuang
authors.initials: S
authors.lastname: Cai
authors.affiliation: Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Aires
authors.affiliation: Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.
authors.forename: M Laird
authors.initials: ML
authors.lastname: Forrest
keywords: Biodistribution; Human head and neck squamous cell carcinoma; Hyaluronic acid; Lanthanum