title: [HLA-G: from feto-maternal tolerance to organ acceptance].
abstract: HLA-G is a nonclassical class I molecule that differs from classical antigens by its restricted expression, very low polymorphism, expression of 7 different protein isoforms, and immune tolerance-inducing activity. HLA-G plays a key role in feto-maternal tolerance. Its interaction with three specific receptors expressed on immune cells (T, B, natural killer and antigen-presenting cells) allows it to act at all levels of the immune response. HLA-G can also be expressed by tumor cells and their microenvironment, endowing them with significant local tolerance. The same is true in some inflammatory and viral diseases.
authors.forename: Edgardo D
authors.initials: ED
authors.lastname: Carosella
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D046528:Chimerism; D003656:Decidua / Q000276:immunology; D005260:Female; D005333:Fetus / Q000276:immunology; D005805:Genes, MHC Class I; D006085:Graft Survival / Q000276:immunology; D059951:HLA-G Antigens / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D064593:Heterografts / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D059630:Mesenchymal Stem Cells / Q000276:immunology; D051379:Mice; D009369:Neoplasms / Q000276:immunology; D011247:Pregnancy / Q000276:immunology; D020033:Protein Isoforms / Q000235:genetics / Q000276:immunology; D014181:Transplantation Immunology; D019139:Tumor Escape / Q000276:immunology; D059016:Tumor Microenvironment / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology
chemical_list: D059951:HLA-G Antigens; D020033:Protein Isoforms