title: Dendrimers in anticancer drug delivery: mechanism of interaction of drug and dendrimers.
abstract: Dendrimers represents a novel class of macromolecules, which are derived from branches upon branches type structural design. Dendrimers are emerging as promising drug-delivery molecule because of their extraordinary properties including membrane interaction, monodispersity, well-defined size, shape and molecular weight, etc. Drugs interact with dendrimers in three ways; (a) physical encapsulation, (b) electrostatic interactions, and (c) covalent conjugations. Due to compact, globular structure and availability of interior cavity spaces and multiple surface functional groups, drug molecules can be encapsulated both in the interior of the dendrimers (physical encapsulation) as well as attached to the surface functional groups (covalent conjugations).
authors.affiliation: a Pharmaceutical Nanotechnology Research Laboratory , ISF College of Pharmacy , Moga , Punjab , India ;
authors.forename: Jaspreet
authors.initials: J
authors.lastname: Singh
authors.affiliation: a Pharmaceutical Nanotechnology Research Laboratory , ISF College of Pharmacy , Moga , Punjab , India ;|b National Institute of Pharmaceutical Education and Research (NIPER Raebareli) , Raebareli , Uttar Pradesh , India ;
authors.forename: Keerti
authors.initials: K
authors.lastname: Jain
authors.affiliation: a Pharmaceutical Nanotechnology Research Laboratory , ISF College of Pharmacy , Moga , Punjab , India ;|c Department of Pharmaceutical Sciences , Irma Lerma Rangel College of Pharmacy, Texas A & M Health Science Center, Texas A & M University , Kingsville , TX , USA ;
authors.forename: Neelesh Kumar
authors.initials: NK
authors.lastname: Mehra
authors.affiliation: a Pharmaceutical Nanotechnology Research Laboratory , ISF College of Pharmacy , Moga , Punjab , India ;|d School of Pharmaceutical Sciences, Rajiv Gandhi Technical University , Bhopal , Madhya Pradesh , India.
authors.forename: N K
authors.initials: NK
authors.lastname: Jain
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D050091:Dendrimers / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers
keywords: Anticancer drugs; dendrimers; generations; mechanisms of interaction; polymers.