title: Association between EPHX1 rs1051740 and lung cancer susceptibility: a meta-analysis.
abstract: BACKGROUND
  Microsomal epoxide hydrolase 1 (EPHX1) may play an important role in epigenetic change and DNA repair concerned with lung cancer. Several studies have investigated the association between EPHX1 rs1051740 and lung cancer risk, but there is no consensus. Therefore, we performed a meta-analysis to further identify the relationship.
  
  
  METHODS
  The Pubmed and Embase databases were searched for eligible studies. An odds ratio (OR) with 95% confidence intervals (CIs) was used to assess the correlation between EPHX1 rs1051740 polymorphism and lung cancer risk through a meta-analysis.
  
  
  RESULTS
  Overall, no significant relationship was found between EPHX1 rs1051740 and lung cancer risk (CC vs. TT: OR=1.10, 95% CI=0.88-1.36; CC+CT vs. TT: OR=1.02, 95% CI=0.88-1.18; CC vs. TT+CT: OR=1.08, 95% CI=0.91-1.27; C vs. T: OR=1.04, 95% CI=0.93-1.17; CT vs. TT: OR=0.98, 95% CI=0.85-1.13). Nevertheless, further subgroup analysis by ethnicity demonstrated that EPHX1 rs1051740 with CC genotype or C allele was an increased risk for lung cancer in Asians (CC vs. TT: OR=1.54, 95% CI=1.23-1.94; CC vs. TT+CT: OR=1.43, 95% CI=1.20-1.71; C vs. T: OR=1.26, 95% CI=1.08-1.47).
  
  
  CONCLUSIONS
  This meta-analysis indicates that EPHX1 rs1051740 with CC genotype or C allele may be a risk factor in Asians.
authors.affiliation: Department of Respiratory Medicine, Huashan Hospital North, Fudan University Shanghai 201907, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Huashan Hospital North, Fudan University Shanghai 201907, China.
authors.forename: Youzhi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Huashan Hospital North, Fudan University Shanghai 201907, China.
authors.forename: Haihua
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Respiratory Medicine, Huashan Hospital North, Fudan University Shanghai 201907, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Huashan Hospital North, Fudan University Shanghai 201907, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, Huashan Hospital North, Fudan University Shanghai 201907, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Long
keywords: EPHX1; lung cancer; polymorphism