title: Impact of hypovitaminosis D on clinical, hormonal and insulin sensitivity parameters in normal body mass index polycystic ovary syndrome women.
abstract: Earlier data on the relationship of 25 hydroxyvitamins (25OHD) levels with various components of polycystic ovary syndrome (PCOS) has been conflicting. We studied 122 normal body mass index (BMI) women with PCOS (cases) and 46 age and BMI-matched healthy women (controls) and assessed the impact of serum 25OHD levels on clinical, biochemical and insulin sensitivity parameters in these lean Indian women with PCOS. The mean age and BMI of the cases and controls were comparable. Mean serum 25OHD levels respectively were 10.1 ± 9.9 and 7.9 ± 6.8 ng/ml with 87.7% and 91.1% vitamin D (VD) deficient. No significant correlation was noted between 25OHD levels and clinical, biochemical and insulin sensitivity parameters except with the total testosterone levels (p = 0.007). Also, no significant difference in these parameters was observed once the PCOS women were stratified into various subgroups based on the serum 25OHD levels. We conclude that VD deficiency being common in normal BMI Indian women with or without PCOS does not seem to alter the metabolic phenotype in these women.
authors.affiliation: a Department of Endocrinology , Metabolism and Diabetes, All India Institute of Medical Sciences , New Delhi , India .
authors.forename: Mohd Ashraf
authors.initials: MA
authors.lastname: Ganie
authors.affiliation: b Department of Endocrinology , ILSI India , New Delhi , India .
authors.forename: Raman Kumar
authors.initials: RK
authors.lastname: Marwaha
authors.affiliation: c Department of Geriatric Medicine , All India Institute of Medical Sciences , New Delhi , India .
authors.forename: Sobia
authors.initials: S
authors.lastname: Nisar
authors.affiliation: d Department of Endocrinology .
authors.forename: Khalid Jamal
authors.initials: KJ
authors.lastname: Farooqi
authors.affiliation: e Department of Internal Medicine .
authors.forename: Rafi Ahmed
authors.initials: RA
authors.lastname: Jan
authors.affiliation: f Department of Urology .
authors.forename: Saleem Ahmed
authors.initials: SA
authors.lastname: Wani
authors.affiliation: g Department of Radiodiagnosis , and.
authors.forename: Tariq
authors.initials: T
authors.lastname: Gojwari
authors.affiliation: h Department of Immunology and Molecular Medicine , Sheri-Kashmir Institute of Medical Sciences , Srinagar , India.
authors.forename: Zaffar Amin
authors.initials: ZA
authors.lastname: Shah
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007194:India; D007333:Insulin Resistance; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D013739:Testosterone / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D055815:Young Adult
chemical_list: D014807:Vitamin D; D013739:Testosterone; C104450:25-hydroxyvitamin D
keywords: India; Polycystic ovary syndrome; insulin resistance; vitamin D deficiency