title: Burkitt lymphoma in a child with Bloom syndrome.
abstract: BACKGROUND
  Bloom syndrome is a rare disease characterized by chromosomal instability and increased risk of developing lymphoma.
  
  
  METHODS
  We report on a case of Bloom syndrome in a 5-year-old boy with Burkitt lymphoma. The diagnosis was suspected by growth retardation, repeated respiratory infections, facial telangiectasia, and a low immunoglobulin level, then confirmed cytogenetically by sister chromatid exchanges. Chemotherapy was poorly tolerated, which required reducing the doses. Unfortunately, it was not sufficient to control the neoplasm and the patient died 14 months after diagnosis.
  
  
  CONCLUSIONS
  Cancers in Bloom syndrome are a challenge since the potentially life-threatening side effects of the chemotherapy may require modifications in standard treatment such as dose reduction, which can compromise the tumor prognosis.
authors.affiliation: Department of pediatric A, Bechir Hamza Children Hospital, Tunis-el Manar, Tunisia. Electronic address: faten.fedhila@yahoo.fr.
authors.forename: F
authors.initials: F
authors.lastname: Fedhila-Ben Ayed
authors.affiliation: Department of Pediatric Radiology, Bechir Hamza Children Hospital, Tunis-el Manar, Tunisia.
authors.forename: W
authors.initials: W
authors.lastname: Douira-Khomsi
authors.affiliation: Department of pediatric A, Bechir Hamza Children Hospital, Tunis-el Manar, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Rhayem
authors.affiliation: Department of pediatric A, Bechir Hamza Children Hospital, Tunis-el Manar, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Jelassi
authors.affiliation: Department of dermatology, Rabta Hospital, Tunis-el Manar, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Zribi
authors.affiliation: Department of genetics, Charles-Nicolle Hospital, Tunis-el Manar, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Chaabouni
authors.affiliation: Department of pediatric A, Bechir Hamza Children Hospital, Tunis-el Manar, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Khemiri
authors.affiliation: Department of Pediatric Radiology, Bechir Hamza Children Hospital, Tunis-el Manar, Tunisia.
authors.forename: I
authors.initials: I
authors.lastname: Bellagha
authors.affiliation: Department of pediatric A, Bechir Hamza Children Hospital, Tunis-el Manar, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Barsaoui
mesh_terms: D001816:Bloom Syndrome / Q000150:complications*; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D002675:Child, Preschool; D017809:Fatal Outcome; D006801:Humans; D008297:Male