title: Recent advances in peptides for enhancing transdermal macromolecular drug delivery.
abstract: Transdermal delivery of drugs, a compelling route of systemic drug delivery, provides painless, reliable, targeted, efficient and cost effective therapeutic regimen for patients. However, its use is limited by skin barrier especially the stratum corneum barrier. Moreover, transdermal delivery of macromolecules remains a challenge. Naturally, varieties of physical methods, chemical enhancers and drug carriers have been used to counteract this limitation. Recently, transdermal peptides discovered as safer, more efficient and more specific enhancers could promote the delivery of macromolecules across the skin. Herein, the underlying transdermal peptides are included. Subsequently, we have discussed typical applications and the possible mechanism of two groups of biologically inspired transdermal peptide enhancers, namely cell penetration peptides and transdermal enhanced peptides.
authors.affiliation: School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230027, China.|Department of Pharmacology, Anhui University of Chinese Medicine, Hefei, Anhui 230038, China.
authors.forename: Renquan
authors.initials: R
authors.lastname: Ruan
authors.affiliation: School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230027, China.|Department of Electronic Science & Technology, University of Science & Technology of China, Hefei, Anhui 230027, China.|Fujian Longsheng Biotechnology (group) Co., Ltd, Longyan, Fujian, 364000, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Pharmacology, Anhui University of Chinese Medicine, Hefei, Anhui 230038, China.|Anhui Anke Biotechnology (group) Co., Ltd, Hefei, Anhui, 230088, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zou
authors.affiliation: School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230027, China.|Center for Biomedical Engineering, University of Science & Technology of China, Hefei, Anhui 230027, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Wei
authors.affiliation: Department of Pharmacology, Anhui University of Chinese Medicine, Hefei, Anhui 230038, China.|Anhui Anke Biotechnology (group) Co., Ltd, Hefei, Anhui, 230088, China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pharmacology, Anhui University of Chinese Medicine, Hefei, Anhui 230038, China.|Anhui Anke Biotechnology (group) Co., Ltd, Hefei, Anhui, 230088, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Ding
authors.affiliation: School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230027, China.
authors.forename: Longping
authors.initials: L
authors.lastname: Wen
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D012869:Skin Absorption
chemical_list: D004337:Drug Carriers; D010455:Peptides; C015462:polyarginine
keywords: applications; mechanism; transdermal delivery; transdermal enhanced peptides