title: Influence of platelet-derived growth factor on osseous remodeling properties of a variable-thread tapered dental implant in vivo.
abstract: OBJECTIVE
  To evaluate the effect of platelet-derived growth factor (rhPDGF-BB) on the promotion of osteogenesis around variable-thread tapered implants in an animal model.
  
  
  METHODS
  Twenty-four variable-thread tapered implants were inserted in the tibia of 12 rabbits. Twelve sites received additional rhPDGF-BB released from a presoaked xenogenic bone block that was fixed supracrestally. Primary outcomes were bone-to-implant contact (BIC; in % ± SD) and percentage of medullary bone fill around the implants (PMF; in % ± SD) after 3 weeks (PDGF n = 6, no PDGF n = 6) and 6 weeks (PDGF n = 6, no PDGF n = 6).
  
  
  RESULTS
  Considerable crestal and medullary bone remodeling could be found around all implants. After 3 weeks, both BIC and PMF values were higher in the no PDGF group (BIC: 63% ± 10 with PDGF vs. 85% ± 5 with no PDGF; PMF: 57% ± 10 with PDGF vs. 74% ± 4 with no PDGF). After 6 weeks, the BIC difference between the two groups was less distinct (BIC: 78% ± 17 with PDGF vs. 72% ± 25 with no PDGF), whereas the PDGF group showed higher PMF values (PMF: 77% ± 5 with PDGF vs. 56% ± 10 with no PDGF).
  
  
  CONCLUSIONS
  The addition of rhPDGF-BB decreases early osseous crestal and medullar healing properties around dental implants. In a later phase, an increase in the cortical area as well as an increased medullar bone formation was seen. This response is likely to provide stronger secondary stability and stability in suboptimal situations involving poor-quality bone.
authors.affiliation: Department of Oral, Maxillofacial and Plastic Surgery, University Medical Center Rostock, Rostock, Germany.
authors.forename: Peer W
authors.initials: PW
authors.lastname: Kämmerer
authors.affiliation: Department of Oral, Maxillofacial and Plastic Surgery, University Medical Center Mainz, Mainz, Germany.
authors.forename: Eik
authors.initials: E
authors.lastname: Schiegnitz
authors.affiliation: Department of Oral and Maxillofacial Surgery and Oral Implantology, "A. Gutan" of the State University of Medicine and Pharmacy "N. Testemitanu,", Chisinau, Moldova.
authors.forename: Victor
authors.initials: V
authors.lastname: Palarie
authors.affiliation: Department of Oral, Maxillofacial and Plastic Surgery, University Medical Center Rostock, Rostock, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Dau
authors.affiliation: Department of Oral, Maxillofacial and Plastic Surgery, University Medical Center Rostock, Rostock, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Frerich
authors.affiliation: Department of Oral, Maxillofacial and Plastic Surgery, University Medical Center Mainz, Mainz, Germany.
authors.forename: Bilal
authors.initials: B
authors.lastname: Al-Nawas
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects*; D015921:Dental Implants; D020007:Implants, Experimental; D023421:Models, Animal; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011446:Prospective Studies; D011817:Rabbits; D013977:Tibia / Q000601:surgery
chemical_list: D015921:Dental Implants; D010982:Platelet-Derived Growth Factor
keywords: bone-implant contact; growth factor; medullary remodeling; osseointegration; platelet-derived growth factor; primary stability; secondary stability; variable-thread tapered implant