title: N,N'-Substituted Selenoureas as Polyfunctional Antioxidants.
abstract: Analysis of antioxidant activity of synthesized selenourea derivatives showed that N,N'-substituted selenoureas inhibited Fe(III)-induced LPO in rat brain homogenate. On the other hand, oxygen- and sulfur-containing analogs exhibited no antioxidant activity or even slight prooxidant activity. Intramolecular alkylation of selenium atom also led to loss of antioxidant activity. Thus, antioxidant activity of the compounds was due to the presence of a nonalkylated selenium atom in N,N'-substituted selenourea analogs.
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Russia. neganova83@mail.ru.
authors.forename: M E
authors.initials: ME
authors.lastname: Neganova
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Proshin
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: O M
authors.initials: OM
authors.lastname: Redkozubova
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Serkov
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: T P
authors.initials: TP
authors.lastname: Serkova
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: L G
authors.initials: LG
authors.lastname: Dubova
authors.affiliation: Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: E F
authors.initials: EF
authors.lastname: Shevtsova
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005290:Ferric Compounds / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D016566:Organoselenium Compounds / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D005290:Ferric Compounds; D016566:Organoselenium Compounds; D017382:Reactive Oxygen Species; C081959:selenourea; D014508:Urea
keywords: antioxidant; lipid peroxidation; selenourea