title: Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice.
abstract: Artemisia annua L. (AA) is a well-known source of the antimalarial drug artemisinin. AA also has an antibacterial and antioxidant activity. However, the effect of AA extract on hepatic steatosis induced by obesity is unclear. We investigated whether AA extract prevents obesity-induced insulin resistance and hepatic steatosis in high-fat diet (HFD)-fed mice. Mice were randomly divided into groups that received a normal chow diet or HFD with or without AA for 12 weeks. We found that AA extract reduced insulin resistance and hepatic steatosis in HFD-fed mice. Western blot analysis showed that HFD-induced expression of nuclear sterol regulatory element-binding protein 1 and carbohydrate-responsive element-binding protein in the livers was decreased by AA extract. In particular, dietary administration of AA extract decreased hepatic high-mobility group box 1 and cyclooxygenase-2 expression in HFD-fed mice. AA extract also attenuated HFD-induced collagen deposition and fibrosis-related transforming growth factor-β1 and connective tissue growth factor. These data indicate that dietary AA extract has beneficial effects on hepatic steatosis and inflammation in HFD-fed mice.
authors.affiliation: 1 Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, Gyeongsang National University School of Medicine , Gyeongnam, Republic of Korea.
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Kim
authors.affiliation: 2 Gyeongnam Oriental Medicinal Herb Institute , Gyeongnam, Republic of Korea.|3 Division of Food Science, Gyeongnam National University of Science and Technology , Gyeongnam, Republic of Korea.
authors.forename: Keon-Hee
authors.initials: KH
authors.lastname: Ko
authors.affiliation: 1 Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, Gyeongsang National University School of Medicine , Gyeongnam, Republic of Korea.
authors.forename: Rok Won
authors.initials: RW
authors.lastname: Heo
authors.affiliation: 1 Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, Gyeongsang National University School of Medicine , Gyeongnam, Republic of Korea.
authors.forename: Chin-ok
authors.initials: CO
authors.lastname: Yi
authors.affiliation: 1 Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, Gyeongsang National University School of Medicine , Gyeongnam, Republic of Korea.
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Shin
authors.affiliation: 4 Busan Regional Korea Food and Drug Administration , Ministry of Food and Drug Safety, Busan, Republic of Korea.
authors.forename: Jun Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: 5 Shinseon F&V Co., Ltd. , Gyeongnam, Republic of Korea.
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Park
authors.affiliation: 3 Division of Food Science, Gyeongnam National University of Science and Technology , Gyeongnam, Republic of Korea.
authors.forename: Sanghae
authors.initials: S
authors.lastname: Nam
authors.affiliation: 1 Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, Gyeongsang National University School of Medicine , Gyeongnam, Republic of Korea.
authors.forename: Hwajin
authors.initials: H
authors.lastname: Kim
authors.affiliation: 1 Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, Gyeongsang National University School of Medicine , Gyeongnam, Republic of Korea.
authors.forename: Gu Seob
authors.initials: GS
authors.lastname: Roh
mesh_terms: D000818:Animals; D031172:Artemisia annua / Q000737:chemistry*; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000276:immunology; D059305:Diet, High-Fat / Q000009:adverse effects; D005234:Fatty Liver / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000276:immunology
chemical_list: D010936:Plant Extracts; D051780:Sterol Regulatory Element Binding Protein 1; D051546:Cyclooxygenase 2
keywords: Artemisia annua L.; hepatic inflammation; hepatic steatosis; obesity