title: Impact of Monochorionicity and Twin to Twin Transfusion Syndrome on Prenatal Attachment, Post Traumatic Stress Disorder, Anxiety and Depressive Symptoms.
abstract: Monochronioric (MC) twin pregnancies are considered as high-risk pregnancies with potential complications requiring in-utero interventions. We aimed to assess prenatal attachment, anxiety, post-traumatic stress disorder (PTSD) and depressive symptoms in MC pregnancies complicated with Twin-To-Twin-transfusion syndrome (TTTS) in comparison to uncomplicated monochorionic (UMC) and dichorionic pregnancies (DC). Auto-questionnaires were filled out at diagnosis of TTTS and at successive milestones. Prenatal attachment, PTSD, anxiety and perinatal depression were evaluated respectively by the Prenatal Attachment Inventory (PAI) completed for each twin, the Post-traumatic Checklist Scale (PCLS), the State-Trait Anxiety Inventory (STAI) and the Edinburgh Perinatal Depression Scale (EPDS). There was no significant difference in the PAI scores between the two twins. In the DC and UMC groups, PAI scores increased throughout pregnancy, whilst it didn't for TTTS group. TTTS and DC had a similar prenatal attachment while MC mothers expressed a significantly higher attachment to their fetuses and expressed it earlier. At the announcement of TTTS, 72% of the patients present a score over the threshold at the EPDS Scale, with a higher score for TTTS than for DC (p = 0.005), and UMC (p = 0.007) at the same GA. 30% of mothers in TTTS group have PTSD during pregnancy. 50% of TTTS- patients present an anxiety score over the threshold (STAI-Scale), with a score significantly higher in TTTS than in UMC (p<0.001) or DC (p<0.001). The proportion of subject with a STAI-State over the threshold is also significantly higher in TTTS than in DC at 20 GW (p = 0.01) and at 26 GW (p<0.05). The STAI-state scores in UMC and DC increase progressively during pregnancy while they decrease significantly in TTTS. TTTS announcement constitutes a traumatic event during a pregnancy with an important risk of PTSD, high level of anxiety and an alteration of the prenatal attachment. These results should guide the psychological support provided to these patients.
authors.affiliation: Department of Child and Adolescent Psychiatry, Necker-Enfants-Malades Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Berengere
authors.initials: B
authors.lastname: Beauquier-Maccotta
authors.affiliation: Obstetrics and Fetal Medicine Department, Necker-Enfants-Malades Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|Rare Disease Center- TTTS, Necker-Enfants-Malades Hospital, APHP, Paris, France.
authors.forename: Gihad E
authors.initials: GE
authors.lastname: Chalouhi
authors.affiliation: Rare Disease Center- TTTS, Necker-Enfants-Malades Hospital, APHP, Paris, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Picquet
authors.affiliation: Obstetrics and Fetal Medicine Department, Necker-Enfants-Malades Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|Rare Disease Center- TTTS, Necker-Enfants-Malades Hospital, APHP, Paris, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Carrier
authors.affiliation: Rare Disease Center- TTTS, Necker-Enfants-Malades Hospital, APHP, Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Bussières
authors.affiliation: Department of Child and Adolescent Psychiatry, Necker-Enfants-Malades Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Golse
authors.affiliation: Obstetrics and Fetal Medicine Department, Necker-Enfants-Malades Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|Rare Disease Center- TTTS, Necker-Enfants-Malades Hospital, APHP, Paris, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Ville
mesh_terms: D000328:Adult; D001007:Anxiety / Q000503:physiopathology / Q000517:prevention & control / Q000523:psychology*; D002823:Chorion / Q000098:blood supply / Q000503:physiopathology; D003863:Depression / Q000503:physiopathology / Q000517:prevention & control / Q000523:psychology*; D037001:Directive Counseling; D005260:Female; D005330:Fetofetal Transfusion / Q000503:physiopathology; D006801:Humans; D009769:Object Attachment; D011247:Pregnancy; D018566:Pregnancy, High-Risk / Q000523:psychology*; D059285:Pregnancy, Twin / Q000523:psychology*; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology / Q000517:prevention & control / Q000523:psychology*; D014430:Twins, Monozygotic