title: An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor.
abstract: Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.
authors.affiliation: The Sainsbury Laboratory, Norwich, United Kingdom.
authors.forename: Yasin F
authors.identifier: http://orcid.org/0000-0002-9502-355X
authors.initials: YF
authors.lastname: Dagdas
authors.affiliation: The Sainsbury Laboratory, Norwich, United Kingdom.
authors.forename: Khaoula
authors.initials: K
authors.lastname: Belhaj
authors.affiliation: Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom.
authors.forename: Abbas
authors.initials: A
authors.lastname: Maqbool
authors.affiliation: The Sainsbury Laboratory, Norwich, United Kingdom.
authors.forename: Angela
authors.initials: A
authors.lastname: Chaparro-Garcia
authors.affiliation: Department of Life Sciences, Imperial College London, London, United Kingdom.
authors.forename: Pooja
authors.initials: P
authors.lastname: Pandey
authors.affiliation: The Sainsbury Laboratory, Norwich, United Kingdom.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Petre
authors.affiliation: Department of Life Sciences, Imperial College London, London, United Kingdom.
authors.forename: Nadra
authors.identifier: http://orcid.org/0000-0002-2722-9441
authors.initials: N
authors.lastname: Tabassum
authors.affiliation: The Sainsbury Laboratory, Norwich, United Kingdom.
authors.forename: Neftaly
authors.initials: N
authors.lastname: Cruz-Mireles
authors.affiliation: Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom.
authors.forename: Richard K
authors.initials: RK
authors.lastname: Hughes
authors.affiliation: The Sainsbury Laboratory, Norwich, United Kingdom.
authors.forename: Jan
authors.initials: J
authors.lastname: Sklenar
authors.affiliation: The Sainsbury Laboratory, Norwich, United Kingdom.
authors.forename: Joe
authors.initials: J
authors.lastname: Win
authors.affiliation: The Sainsbury Laboratory, Norwich, United Kingdom.
authors.forename: Frank
authors.initials: F
authors.lastname: Menke
authors.affiliation: Department of Cell and Developmental Biology, John Innes Centre, Norwich, United Kingdom.
authors.forename: Kim
authors.initials: K
authors.lastname: Findlay
authors.affiliation: Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom.
authors.forename: Mark J
authors.identifier: http://orcid.org/0000-0001-8921-3835
authors.initials: MJ
authors.lastname: Banfield
authors.affiliation: The Sainsbury Laboratory, Norwich, United Kingdom.
authors.forename: Sophien
authors.identifier: http://orcid.org/0000-0002-0290-0315
authors.initials: S
authors.lastname: Kamoun
authors.affiliation: The Sainsbury Laboratory, Norwich, United Kingdom.|Department of Life Sciences, Imperial College London, London, United Kingdom.
authors.forename: Tolga O
authors.initials: TO
authors.lastname: Bozkurt
mesh_terms: D001343:Autophagy; D005656:Fungal Proteins / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D055750:Phytophthora infestans / Q000472:pathogenicity*; D010935:Plant Diseases / Q000276:immunology / Q000382:microbiology*; D010940:Plant Proteins / Q000378:metabolism*; D011485:Protein Binding; D011198:Solanum tuberosum / Q000276:immunology / Q000382:microbiology*
chemical_list: D005656:Fungal Proteins; D010940:Plant Proteins
keywords: Irish potato famine; Nicotiana benthamiana; Phytophthora infestans; autophagy; effectors; infectious disease; late blight disease; microbiology; plant biology