title: Modified inflammation-based score as an independent malignant predictor in patients with pulmonary focal ground-glass opacity: a propensity score matching analysis.
abstract: Pulmonary focal Ground-glass Opacities (fGGOs) would frequently be identified after widely implementation of low-dose computed tomography (LDCT) screening. Because of the high false-positive rate of LDCT, antibiotics should be regarded as advocates in clinical management for detected fGGOs. Retrospectively review consecutive patients with fGGOs between August 2006 and August 2012. Then, relative Glasgow prognostic score (GPS) were constructed in three different systems, traditional GPS system (tGPS), modified GPS system 1 (m1GPS), and modified GPS system 2 (m2GPS). Moreover, propensity score matching (PSM) was employed in balancing baseline covariates. After PSM, patients were matched and included in benign and malignant groups as 1:1 ratio. All reported parameters were balanced in both groups and no statistical differences could be detected. Finally, m1GPS exhibited remarkable different distribution between benign and malignant fGGOs. In detail, m1GPS 1 was more frequently observed in benign fGGOs nodules, while m1GPS 2 in malignant fGGOs nodules. Modified inflammation-based score was identified as an independent predictor of malignancies in patients with pulmonary fGGOs. Patients with m1GPS 1 were more likely to be benign fGGOs, while victims with m1GPS 2 more likely to be malignant.
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.|Lung Cancer Institute of Sun Yat-sen University, Guangzhou 510060, China.|Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.|University of California, San Francisco, San Francisco, USA.
authors.forename: Long
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.|Lung Cancer Institute of Sun Yat-sen University, Guangzhou 510060, China.|Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Yongbin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.|Lung Cancer Institute of Sun Yat-sen University, Guangzhou 510060, China.|Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Han
authors.initials: H
authors.lastname: Yang
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.|Lung Cancer Institute of Sun Yat-sen University, Guangzhou 510060, China.|Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Zerui
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.|Lung Cancer Institute of Sun Yat-sen University, Guangzhou 510060, China.|Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Zehua
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.|Lung Cancer Institute of Sun Yat-sen University, Guangzhou 510060, China.|Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Yaobin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.|Lung Cancer Institute of Sun Yat-sen University, Guangzhou 510060, China.|Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Long
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D008875:Middle Aged; D057216:Propensity Score; D016896:Treatment Outcome; D055815:Young Adult