title: New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone.
abstract: A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.
authors.affiliation: Department of Biochemistry and Molecular Biology, The Biomedicine Discovery Institute, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
authors.forename: Hsiao P J
authors.initials: HP
authors.lastname: Voon
authors.affiliation: Department of Biochemistry and Molecular Biology, The Biomedicine Discovery Institute, Monash University, Wellington Road, Clayton, Victoria 3800, Australia lee.wong@monash.edu.
authors.forename: Lee H
authors.initials: LH
authors.lastname: Wong
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D056970:Co-Repressor Proteins; D004265:DNA Helicases / Q000235:genetics*; D015894:Genome, Human; D006570:Heterochromatin / Q000235:genetics*; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics; D006657:Histones / Q000235:genetics*; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics; D046912:Multiprotein Complexes / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics*; D000075924:X-linked Nuclear Protein
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D056970:Co-Repressor Proteins; C106985:DAXX protein, human; D006570:Heterochromatin; D006657:Histones; D018832:Molecular Chaperones; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D011495:Histone-Lysine N-Methyltransferase; D004265:DNA Helicases; C092332:ATRX protein, human; D000075924:X-linked Nuclear Protein