title: Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity.
abstract: OBJECTIVE
  The aim of this study was to establish the association between anthropometric parameters and non-alcoholic fatty liver disease (NAFLD) and to determine the most reliable measurement as a parameter in predicting NAFLD.
  
  
  METHODS
  Two-hundred fifty-three obese children of ages 10 to 18 years were enrolled in this study. Anthropometric data and metabolic parameters such as fasting blood glucose, insulin and lipid levels, were measured. Liver function tests were assessed. NAFLD was determined by ultrasound.
  
  
  RESULTS
  Most metabolic parameters and anthropometric indices were significantly higher in children with NAFLD. A univariate logistic regression analysis was performed, taking NAFLD status as the dependent variable and anthropometric parameters as the independent variables. NAFLD was affected significantly by the anthropometric values. The multiple logistic regression analysis showed that neck circumference (NC) was the only parameter which determined the risk in both genders. Each 1 cm increase in the NC increased the risk of NAFLD 1.544-fold (p<0.001, 95% confidence interval (CI): 1.357-2.214) in the boys and 1.733-fold (p=0.001, 95% CI: 1.185-2.012) in the girls. Receiver operating characteristic analysis was performed to compare the reliability of anthropometric measurements. NC was observed to be a better indicator.
  
  
  CONCLUSIONS
  Measurement of the NC was shown to be associated with NAFLD in children. We suggest the use of NC as a novel, simple, practical, and reliable anthropometric index in predicting children at risk for NAFLD.
authors.affiliation: Erciyes University Faculty of Medicine, Department of Pediatric Endocrinology, Kayseri, Turkey, Phone: +90 352 438 00 76 E-mail: nihalhatipoglu@yahoo.com.
authors.forename: Nihal
authors.initials: N
authors.lastname: Hatipoğlu
authors.forename: Serap
authors.initials: S
authors.lastname: Doğan
authors.forename: M Mümtaz
authors.initials: MM
authors.lastname: Mazıcıoğlu
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoğlu
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology*; D009333:Neck / Q000473:pathology*; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology / Q000209:etiology*; D063766:Pediatric Obesity / Q000150:complications*; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D055105:Waist Circumference