title: Whole brain C-arm computed tomography parenchymal blood volume measurements.
abstract: BACKGROUND
  C-arm flat detector computed tomography (FDCT) parenchymal blood volume (PBV) imaging in the neuro-interventional suite is a new technique for which detailed whole brain measurements have not been previously reported. This study aims to create a catalogue of PBV measurements for various anatomical regions encompassing the whole brain, using a three-dimensional volume-of-interest (3D-VOI) analysis.
  
  
  METHODS
  We acquired and analysed 30 C-arm FDCT datasets from 26 patients with aneurysmal subarachnoid haemorrhage (SAH), as part of a prospective study comparing C-arm computed tomography (CT) PBV with magnetic resonance perfusion-weighted imaging (MR-PWI). We calculated the PBV values for various brain regions with an automated analysis, using 58 pre-defined atlas-based 3D-VOIs encompassing the whole brain. VOIs partially or completely overlapping regions of magnetic resonance diffusion weighted imaging (MR-DWI) abnormality or magnetic resonance cerebral blood flow (MR-CBF) asymmetry were excluded from the analysis.
  
  
  RESULTS
  Of the 30 C-arm CT PBV datasets, 14 (54%; 12 patients) had areas of restricted diffusion, the majority of which were focal. The PBV values for the cerebral cortex and cerebral white matter were 4.01 ± 0.47 (mean ± SD) and 3.01 ± 0.39 ml per 100 ml. Lobar PBV values were: frontal lobe 4.2 ± 0.8, temporal lobe 4.2 ± 0.9, parietal lobe 3.9 ± 0.7 and occipital lobe 4.3 ± 0.8 ml/100 ml. The basal ganglia and brainstem PBV values were 3.4 ± 0.7 and 4.6 ± 0.6 ml/100 ml, respectively.
  
  
  CONCLUSIONS
  Compared with the typical reference cerebral blood volume (CBV) values reported in the literature for Positron Emission Tomography (PET), the PBV values were relatively high for the white matter and relatively low for the cortical grey matter. The reported catalogue of PBV values for various brain regions would be useful to inform future studies and could be used in clinical practice, when interpreting PBV maps.
authors.affiliation: Nuffield Department of Surgical Sciences, University of Oxford, Headington, Oxford, UK m.kamran@oxon.org.
authors.forename: Mudassar
authors.initials: M
authors.lastname: Kamran
authors.affiliation: Nuffield Department of Surgical Sciences, University of Oxford, Headington, Oxford, UK.
authors.forename: James V
authors.initials: JV
authors.lastname: Byrne
mesh_terms: D000328:Adult; D000368:Aged; D001811:Blood Volume Determination / Q000379:methods*; D001921:Brain / Q000000981:diagnostic imaging*; D002533:Cerebral Angiography / Q000379:methods*; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000098:blood supply; D002560:Cerebrovascular Circulation; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015642:Radiology, Interventional; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D066127:White Matter / Q000033:anatomy & histology / Q000098:blood supply
keywords: C-arm flat detector computed tomography; cerebral blood flow; cerebral blood volume; magnetic resonance imaging; parenchymal blood volume; perfusion-weighted imaging