title: Retrospective comparison of thromboelastography results to postmortem evidence of thrombosis in critically ill dogs: 39 cases (2005-2010).
abstract: OBJECTIVE
  To determine whether there is an association between thromboelastography (TEG) data and necropsy evidence of thrombosis in a cohort of critically ill dogs.
  
  
  METHODS
  Retrospective study (2005-2010).
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Thirty-nine client-owned critically ill dogs for which TEG was performed within 7 days of complete necropsy.
  
  
  METHODS
  None.
  
  
  RESULTS
  Thrombi were found in 26 (67%) dogs. Spayed females (n = 20) were significantly more likely to have thrombosis (P = 0.0127). No significant association was found between presence of thrombosis and any TEG parameter, the calculated coagulation index, results of coagulation testing, type of vascular access, or clinical diagnosis. D-dimers were significantly higher in dogs with thrombosis (P = 0.0207) and a weak positive correlation was found between D-dimer value and number of sites of thrombosis (ρ = 0.18, P = 0.0045). Dogs with WBC > 16 × 10(3) /μL were more likely to have thrombosis compared to others (odds ratio 5.56, 95% confidence interval 1.2-25.7, P = 0.025).
  
  
  CONCLUSIONS
  This study found no association between any TEG parameter and the presence of thrombosis on postmortem examination.
authors.affiliation: Section of Critical Care, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104.
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Thawley
authors.affiliation: Department of Clinical Studies - Philadelphia, and the Laboratory of Pathology and Toxicology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104.
authors.forename: Melissa D
authors.initials: MD
authors.lastname: Sánchez
authors.affiliation: Section of Critical Care, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Drobatz
authors.affiliation: Section of Critical Care, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104.
authors.forename: Lesley G
authors.initials: LG
authors.lastname: King
mesh_terms: D000818:Animals; D001344:Autopsy; D015331:Cohort Studies; D016638:Critical Illness; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products; D006785:Hospitals, University; D008297:Male; D008499:Medical Records; D012189:Retrospective Studies; D013916:Thrombelastography / Q000662:veterinary; D013927:Thrombosis / Q000175:diagnosis / Q000662:veterinary*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D
keywords: DIC; TEG; coagulopathy; disseminated intravascular coagulation; hypercoagulable; viscoelastic testing