title: Low miR-498 expression levels are associated with poor prognosis in ovarian cancer.
abstract: OBJECTIVE
  Decreased expression levels of microRNA (miR)-498 were reported in several human cancers. However, the prognostic value of the miR-498 expression in ovarian cancer has not been assessed. In this study, we addressed this knowledge gap by evaluating an association of miR-498 expression levels with ovarian cancer prognosis.
  
  
  METHODS
  qPCR was used to detect expression levels of miR-498 in cancer specimens and matched adjacent normal tissue specimens. The log-rank test was used to analyze survival rate, whereas the Cox regression model was used fir multivariate analysis of potential prognostic factors.
  
  
  RESULTS
  Expression levels of miR-498 were significantly lower in ovarian cancer tissue specimens compared with matched normal adjacent tissue (p < 0.001). Decreased miR-498 expression levels correlated well with FIGO stage, tumour grade and lymph node metastases (respective p = 0.001, 0.015, and 0.017). Furthermore, patients with lower miR-498 expression had shorter overall and progression-free survival (both p < 0.01 vs. those with high miR-498 expression).
  
  
  CONCLUSIONS
  Decreased expression levels of miR-498 are associated with worse overall survival and poor prognosis in patients with ovarian cancer, highlighting potential usefulness of this miR for prognosis in patients with ovarian cancer.
authors.affiliation: Department of Gynaecology, Qingdao University Affiliated Yantai Yuhuangding Hospital, Yantai, Shandong, China. yn702@163.com.
authors.forename: J
authors.initials: J
authors.lastname: Cong
authors.forename: R
authors.initials: R
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Hou
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D005260:Female; D015870:Gene Expression; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C578093:MIRN498 microRNA, human; D035683:MicroRNAs