title: Cerebrospinal Fluid Alzheimer's Disease Biomarkers in Cerebral Amyloid Angiopathy-Related Inflammation.
abstract: BACKGROUND
  Decreased cerebrospinal fluid (CSF) amyloid-β 1-40 (Aβ40) and amyloid-β 1-42 (Aβ42) and increased total and phosphorylated tau (t-tau, p-tau) concentrations have been described in cerebral amyloid angiopathy (CAA).
  
  
  OBJECTIVE
  Our aim was to analyze these biomarkers in patients with CAA-related inflammation (CAA-I).
  
  
  METHODS
  We prospectively recruited nine patients with acute phase CAA-I fulfilling Chung criteria. CSF was analyzed for t-tau, p-tau, Aβ42, and Aβ40. Data were compared to controls (n = 14), patients with Alzheimer's disease (AD, n = 42), CAA (n = 10), and primary angiitis of the central nervous system (PACNS, n = 3).
  
  
  RESULTS
  For the CAA-I group, statistically significant differences were: lower Aβ42 (p = 0.00053) compared to the control group; lower t-tau (p = 0.018), p-tau (p <  0.001), and Aβ40 (p <  0.001) compared to AD; lower Aβ42 (p = 0.027) compared to CAA; lower Aβ42 (p = 0.012) compared to PACNS. Nearly significantly lower Aβ40 (p = 0.051) and higher t-tau (p = 0.051) were seen in CAA-I compared to controls.
  
  
  CONCLUSIONS
  CSF biomarkers profile similar to that of CAA was observed in CAA-I (with even lower levels of Aβ42 compared to CAA). Based on our findings, high p-tau seems more specific for AD, whereas low Aβ42 differentiates CAA-I from CAA, PACNS, and controls, and low Aβ40 differentiates CAA-I from AD.
authors.affiliation: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Rue du Pr Debré, Nîmes Cedex, France.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Renard
authors.affiliation: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Rue du Pr Debré, Nîmes Cedex, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Wacongne
authors.affiliation: Department of Neurology, CHU Montpellier, Hôpital Gui de Chauliac, Montpellier, France.|The Neuroscience Institute of Montpellier (INM), Inserm UMR1051, CHU Montpellier, Hôpital Saint-Eloi, Montpellier, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Ayrignac
authors.affiliation: Department of Neurology, CHU Montpellier, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Charif
authors.affiliation: Department of Neurology, CH Narbonne, Narbonne, France.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Fourcade
authors.affiliation: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Rue du Pr Debré, Nîmes Cedex, France.
authors.forename: Souhayla
authors.initials: S
authors.lastname: Azakri
authors.affiliation: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Rue du Pr Debré, Nîmes Cedex, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Le Floch
authors.affiliation: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Rue du Pr Debré, Nîmes Cedex, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Bouly
authors.affiliation: Department of Neurology, CHU Montpellier, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Marelli
authors.affiliation: Department of Neurology, CHU Montpellier, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Arquizan
authors.affiliation: Laboratoire de Biochimie-Protéomique Clinique -IRMB -CCBHM - Inserm U11183, CHU Montpellier, Hôpital St-Eloi - Université Montpellier, Montpellier Cedex, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Hirtz
authors.affiliation: Centre Mémoire de Resources et de Recherche Montpellier, CHU Montpellier, Hôpital Gui de Chauliac -Université de Montpellier, Montpellier Cedex, France.|Laboratoire de Biochimie-Protéomique Clinique -IRMB -CCBHM - Inserm U11183, CHU Montpellier, Hôpital St-Eloi - Université Montpellier, Montpellier Cedex, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Gabelle
authors.affiliation: Department of Neurology, CHU Nîmes, Hôpital Caremeau -Université de Montpellier, Nîmes Cedex, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Thouvenot
authors.affiliation: Laboratoire de Biochimie-Protéomique Clinique -IRMB -CCBHM - Inserm U11183, CHU Montpellier, Hôpital St-Eloi - Université Montpellier, Montpellier Cedex, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Lehmann
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D016657:Cerebral Amyloid Angiopathy / Q000134:cerebrospinal fluid / Q000150:complications*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000134:cerebrospinal fluid* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D016875:tau Proteins
keywords: Alzheimer’s disease; amyloid-β; cerebral amyloid angiopathy; cerebrospinal fluid; inflammation; tau