title: Catalytic Role of Manganese Oxides in Prebiotic Nucleobases Synthesis from Formamide.
abstract: Origin of life processes might have begun with the formation of important biomonomers, such as amino acids and nucleotides, from simple molecules present in the prebiotic environment and their subsequent condensation to biopolymers. While studying the prebiotic synthesis of naturally occurring purine and pyrimidine derivatives from formamide, the manganese oxides demonstrated not only good binding for formamide but demonstrated novel catalytic activity. A novel one pot manganese oxide catalyzed synthesis of pyrimidine nucleobases like thymine is reported along with the formation of other nucleobases like purine, 9-(hydroxyacetyl) purine, cytosine, 4(3 H)-pyrimidinone and adenine in acceptable amounts. The work reported is significant in the sense that the synthesis of thymine has exhibited difficulties especially under one pot conditions and also such has been reported only under the catalytic activity of TiO2. The lower oxides of manganese were reported to show higher potential as catalysts and their existence were favored by the reducing atmospheric conditions prevalent on early Earth; thereby confirming the hypothesis that mineral having metals in reduced form might have been more active during the course of chemical evolution. Our results further confirm the role of formamide as a probable precursor for the formation of purine and pyrimidine bases during the course of chemical evolution and origin of life.
authors.affiliation: Department of Agrifood Engineering and Biotecnology, Universitat Politècnica de Catalunya (UPC), 08860, Barcelona, Castelldefels, Spain. brijbhushaniitr@gmail.com.
authors.forename: Brij
authors.initials: B
authors.lastname: Bhushan
authors.affiliation: Energy and Environment Department, Innovació i Recerca Industrial i Sostenible, -08860, Castelldefels, Spain.
authors.forename: Arunima
authors.initials: A
authors.lastname: Nayak
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667(U.K.), India.
authors.lastname: Kamaluddin
mesh_terms: D002384:Catalysis; D019418:Evolution, Chemical; D005559:Formamides / Q000737:chemistry*; D017895:Manganese Compounds / Q000737:chemistry*; D008956:Models, Chemical; D000069497:Origin of Life; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D011687:Purines / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*
chemical_list: D005559:Formamides; D017895:Manganese Compounds; D010087:Oxides; D011687:Purines; D011743:Pyrimidines; C027424:manganese oxide
keywords: Formamide; Manganese oxides; Nucleobases; Prebiotic Catalyst; Thymine