title: Antioxidant 21-aminosteroid "U-74389G" ameliorates the short-time effect of hypoxia-reoxygenation on the platelet count in rats.
abstract: OBJECTIVE
  The aim of this experimental study was to examine the effect of the antioxidant drug "U-74389G", on rat model and particularly in a hypoxia-reoxygenation protocol. The beneficial effect or non-effectiveness of that molecule were studied hematologically using blood mean platelet count. Results were that U-74389G administration interacted or not with reoxygenation time decreased the platelet count by 6.12% ± 3.58% (p = 0.0857) and 12.83% ± 5.79% (p = 0.0303) respectively.
  
  
  CONCLUSIONS
  U-74389G administration interacted or not with reoxygenation time decreases the platelet count within short-term time of 2 hours by different significance levels.
authors.affiliation: Department of Obstetrics & gynecology, Mesologi County Hospital Nafpaktou, Mesolongi, Etoloakarnania, Greece. Constantinostsompos@yahoo.com.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Tsompos
authors.forename: Constantinos
authors.initials: C
authors.lastname: Panoulis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Toutouzas
authors.forename: George
authors.initials: G
authors.lastname: Zografos
authors.forename: Apostolos
authors.initials: A
authors.lastname: Papalois
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology*; D000860:Hypoxia / Q000097:blood / Q000188:drug therapy*; D010976:Platelet Count; D011281:Pregnatrienes / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D011281:Pregnatrienes; C074965:U 74389F
keywords: U-74389G; hypoxia; platelet count; reoxygenation