title: Effect of intranasal steroids on rhinosinusitis after radiotherapy for nasopharyngeal carcinoma: clinical study.
abstract: OBJECTIVE
  Post-irradiation rhinosinusitis is one of the most common untoward side effects in patients with nasopharyngeal carcinoma. This study aimed to evaluate the effect of fluticasone propionate aqueous nasal spray on post-irradiation rhinosinusitis.
  
  
  METHODS
  Nasopharyngeal carcinoma patients who had undergone radiotherapy and subsequently developed chronic rhinosinusitis were randomised to receive either fluticasone propionate aqueous nasal spray 200 µg plus nasal irrigation or a single nasal irrigation, for six months. A questionnaire, nasal endoscopy and computed tomography were used to evaluate rhinosinusitis severity, at the beginning of treatment, and at three and six months after treatment.
  
  
  RESULTS
  The group who received fluticasone propionate aqueous nasal spray combined with irrigation had fewer nasal complaints (overall symptoms, blocked nose and headache were reduced), a better quality of life and less severe endoscopic findings than those who only received nasal irrigation at three and six months after treatment.
  
  
  CONCLUSIONS
  Nasal steroids are a safe and effective therapy for patients with post-irradiation rhinosinusitis.
authors.affiliation: Department of Otolaryngology,Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China.
authors.forename: S
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Otolaryngology,Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China.
authors.forename: Y
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Radiation Oncology,Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China.
authors.forename: Z
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Department of Radiation Oncology,Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China.
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology,Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China.
authors.forename: Z
authors.initials: Z
authors.lastname: Liao
authors.affiliation: Department of Otolaryngology,Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China.
authors.forename: L
authors.initials: L
authors.lastname: Guo
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002277:Carcinoma; D005260:Female; D000068298:Fluticasone / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D055556:Nasal Lavage / Q000379:methods; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects; D012220:Rhinitis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000068298:Fluticasone
keywords: Nasopharyngeal Carcinoma; Radiotherapy; Sinusitis; Steroids