title: The hippocampus may be more susceptible to environmental noise than the auditory cortex.
abstract: Noise exposure can cause structural and functional problem in the auditory cortex (AC) and hippocampus, the two brain regions in the auditory and non-auditory systems respectively. The aim of the present study was to explore which one of these two brain regions may be more susceptible to environmental noise. The AC and hippocampus of mice were separated following 1 or 3 weeks exposure to moderate noise (80 dB SPL, 2 h/day). The levels of oxidative stress and tau phosphorylation were then measured to evaluate the effects by noise. Results showed significant peroxidation and tau hyperphosphorylation in the hippocampus with 1 week of noise exposure. However, the AC did not show significant changes until exposure for 3 weeks. These data suggest that although the hippocampus and AC were affected by moderate noise exposure, the hippocampus in the non-auditory system may have been more vulnerable to environmental noise than the AC.
authors.affiliation: School of Life Sciences & Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan 430079, China; Key Laboratory of Adolescent Cyberpsycology and Behavior (CCNU) of Ministry of Education, Central China Normal University, Wuhan 430079, China; School of Psychology, Central China Normal University, Wuhan 430079, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: School of Life Sciences & Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan 430079, China.
authors.forename: Shao-Hui
authors.initials: SH
authors.lastname: Wang
authors.affiliation: Key Laboratory of Adolescent Cyberpsycology and Behavior (CCNU) of Ministry of Education, Central China Normal University, Wuhan 430079, China; School of Psychology, Central China Normal University, Wuhan 430079, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.affiliation: School of Life Sciences & Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan 430079, China. Electronic address: liaodebox@mail.ccnu.edu.cn.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Liao
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001303:Auditory Cortex / Q000378:metabolism / Q000503:physiopathology*; D001306:Auditory Pathways / Q000503:physiopathology; D004777:Environment; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology*; D015227:Lipid Peroxidation; D051379:Mice; D023421:Models, Animal; D009622:Noise / Q000009:adverse effects*; D018384:Oxidative Stress; D010766:Phosphorylation; D013997:Time Factors; D016875:tau Proteins / Q000378:metabolism
chemical_list: C558298:Mapt protein, mouse; D016875:tau Proteins
keywords: Auditory cortex; Hippocampus; Noise exposure; Oxidation; Tau phosphorylation