title: Electrochemical and bio-sensing platform based on a novel 3D Cu nano-flowers/layered MoS₂ composite.
abstract: A novel 3D nano-flower-like Cu/multi-layer molybdenum disulfide composite (CuNFs/MoS2) modified glassy carbon electrode (GCE) has been successfully constructed. It was a highly sensitive and selective non-enzymatic hydrogen peroxide (H2O2) and glucose biosensor. The morphology of the obtained CuNFs-MoS2 nano-particles was investigated with the use of a scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and energy dispersive X-ray spectroscopy (EDS). The physicochemical properties of the modified electrode were characterized at each of the construction stages with the use of an electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) techniques. The new sensor combined the advantages of MoS2 and CuNFs, and exhibited high electro-catalytic activity toward H2O2 and glucose. Quantitative analysis of H2O2 and glucose was carried out with the use of the amperometric i-t method. Linear ranges were obtained between 0.04-1.88 μM and 1.88-35.6 μM for H2O2 and 1-20 μM and 20-70 μM for glucose, and their corresponding limits of detection (LOD) were 0.021 μM and 0.32 μM. This novel sensor was successfully applied for the quantitative analysis of H2O2 in tap water and glucose in human serum samples.
authors.affiliation: College of Chemistry, Nanchang University, Nanchang 330031, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. Electronic address: ynni@ncu.edu.cn.
authors.forename: Yongnian
authors.initials: Y
authors.lastname: Ni
authors.affiliation: School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane 4001, Australia. Electronic address: s.kokot@qut.edu.au.
authors.forename: Serge
authors.initials: S
authors.lastname: Kokot
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation; D001786:Blood Glucose / Q000032:analysis*; D003300:Copper / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry*; D060766:Drinking Water / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis*; D057230:Limit of Detection; D008982:Molybdenum / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D014961:X-Ray Diffraction
chemical_list: D001786:Blood Glucose; D004220:Disulfides; D060766:Drinking Water; D003300:Copper; D008982:Molybdenum; D006861:Hydrogen Peroxide; C082964:molybdenum disulfide
keywords: 3D Cu nanoflowers; Biosensor; Glucose; Hydrogen peroxide; Molybdenum disulfide