title: Cancer cell identification by bi-color ZnO and TiO2nanowires.
abstract: Semiconductor nanocomposites provide advantages beyond the capability of typical fluorescent materials for cancer detection. In this work, nanowire-based probes with dual color channels are employed to demonstrate the capacity of cancer cell detection. Purple emitting ZnO/antibody probes are applied to detect cancer cells and meanwhile TiO2/antibody probes with green light emission are applied to identify normal fibroblast cells. A series of quantitative analyses are conducted to verify the correlation between the concentrations of ZnO and TiO2probes, cell numbers, and peak intensities of the PL spectra. The results provide a quantitative reference for developing nanowire-based cancel cell probes.
authors.affiliation: Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Sec. 4, Taipei 106, Taiwan.
authors.forename: Wei-Jen
authors.initials: WJ
authors.lastname: Li
authors.affiliation: Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Sec. 4, Taipei 106, Taiwan.
authors.forename: Yung-Tsan
authors.initials: YT
authors.lastname: Chen
authors.affiliation: Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Sec. 4, Taipei 106, Taiwan.
authors.forename: Po-Hao
authors.initials: PH
authors.lastname: Huang
authors.affiliation: Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Sec. 1, Taipei 100, Taiwan.|Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, No. 1, Jen-Ai Road, Sec. 1, Taipei 100, Taiwan.
authors.forename: Tsung-Lin
authors.initials: TL
authors.lastname: Yang
authors.affiliation: Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Sec. 4, Taipei 106, Taiwan.|Department of Electrical Engineering, National Taiwan University, 1, Roosevelt Road, Sec. 4, Taipei 106, Taiwan.
authors.forename: Jian-Jang
authors.initials: JJ
authors.lastname: Huang
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D007834:Lasers; D053770:Nanowires; D009369:Neoplasms / Q000000981:diagnostic imaging; D012666:Semiconductors; D014025:Titanium; D015034:Zinc Oxide
chemical_list: C009495:titanium dioxide; D014025:Titanium; D015034:Zinc Oxide
keywords: TiO2 nanowires; ZnO nanowires; cell detection; nanoprobe