title: Correlation analysis between serum lipoprotein (a) and the incidence of aortic valve sclerosis.
abstract: This clinical trial explores the correlation between serum lipoprotein and the severity of aortic valve sclerosis in patients diagnosed with aortic valve sclerosis (AVS). A total of 1260 subjects diagnosed with AVS were enrolled in this study between May 2005 and June 2013 and divided into the young-aged (30-59 years, n=217), middle-aged (60-74 years, n=561) and elderly groups (75-93 years, n=482). In each group, patients were sub-grouped into AVS and healthy controls according to angiography findings. Parameters including triglyceride (TG), serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), free fatty acid (FFA), lipoprotein (a) [Lp(a)], apolipoprotein A1 (ApoAl) and apolipoprotein B (ApoB) were accurately measured. Correlation between these parameters and the severity of AVS was statistically evaluated. In the middle-aged and elderly groups, serum Lp(a), TC and LDL-C were significantly higher in patients with AVS compared with healthy counterparts (both P<0.05). In the elderly group, serum HDL-C in AVS patients was significantly lower than healthy subjects (P<0.05). In the young-aged group, serum Lp(a) and ApoB were significantly increased compared with healthy counterparts (both P<0.05). Gemini score in the elderly group was significantly higher than the other groups (both P<0.01). No statistical significance was observed in Lp(a) levels among groups I, II and III. The number of coronary stenosis in group III was significantly increased than those in groups I and II (P<0.01). Lp(a), LDL-C and aging act as independent risk factors of AVS and promote the incidence and progress of AVS.
authors.affiliation: Department of Emergency, Xiangya Hospital of Central South University Changsha 410008, P. R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Yang
authors.affiliation: Department of Cardiovascular, Xiangya Hospital of Central South University Changsha 410008, P. R. China.
authors.forename: Guogang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Emergency, Xiangya Hospital of Central South University Changsha 410008, P. R. China.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Emergency, Xiangya Hospital of Central South University Changsha 410008, P. R. China.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhou
keywords: Correlation; aging; aortic valve sclerosis; lipoprotein (a)