title: Vessel Normalization in the Spot-LIGHT of Cancer Treatment.
abstract: Targeting the aberrant, nonfunctional tumor vasculature is one of the most promising approaches of new anticancer therapies. Here, we discuss a recent publication and a novel mechanism by which tumor-associated macrophages can actively induce vessel normalization and junction stability, and improve the distribution of therapeutic drugs into a tumor.
authors.affiliation: Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, B3000 Leuven, Belgium; Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, KU Leuven, B3000 Leuven, Belgium.
authors.forename: Manuel
authors.initials: M
authors.lastname: Ehling
authors.affiliation: Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, B3000 Leuven, Belgium; Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, KU Leuven, B3000 Leuven, Belgium. Electronic address: massimiliano.mazzone@vib-kuleuven.be.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Mazzone
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*
keywords: LIGHT; TGFβ; mural cell contractility; pericytes; tumor associated macrophages; tumor blood vessel normalization