title: The role of GATA3 in breast carcinomas: a review.
abstract: GATA3 is a zinc-binding transcription factor that regulates the differentiation of many human tissue types, including the mammary gland. In surgical pathology, immunohistochemistry for GATA3 is largely used to support urothelial or breast origin in a carcinoma of unknown origin. GATA3 is sensitive but not entirely specific in this setting. Although GATA3 labeling is highest in estrogen receptor-positive carcinomas, it also labels estrogen receptor-negative carcinomas and thus has particular diagnostic utility in the setting of triple-negative breast carcinomas, which are typically negative for other mammary-specific markers.
authors.affiliation: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Asch-Kendrick
authors.affiliation: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231; Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD 21231. Electronic address: acimino1@jhmi.edu.
authors.forename: Ashley
authors.initials: A
authors.lastname: Cimino-Mathews
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D050990:GATA3 Transcription Factor / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry
chemical_list: D014408:Biomarkers, Tumor; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human
keywords: Breast cancer; Differential diagnoses; GATA3; Immunohistochemistry; Surgical pathology