title: Aluminum nanopyramid array with tunable ultraviolet-visible-infrared wavelength plasmon resonances for rapid detection of carbohydrate antigen 199.
abstract: Aluminum-based localized surface plasmon resonance (LSPR) holds attractive properties include low cost, high natural abundance, and ease of processing by a wide variety of methods including complementary metal oxide semiconductor process, making itself having an edge over conventional ones induced by noble metal. However, the inherent drawbacks of plasmonic mode limited on UV-green wavelength, low refractive index sensitivity, as well as heavy-shape-dependence greatly prevent aluminum plasmonics from real-life biosensing. Here, we demonstrated a uniform quasi-3-dimensional Al nanopyramid array (NPA) structure with tunable ultraviolet-visible-infrared (UV-vis-NIR) plasmon resonances for biosensing. By changing the reflection measuring angle, we could easily obtain typical peaks simultaneously exhibited on the reflectance spectrum across UV-vis-NIR wave region. The Al NPAs carried out high refractive index sensitivities which even comparable with that of noble metal, and can be used as a biosensor for directly detecting cytochrome c and carbohydrate antigen 199 in air after the sensing surface was washed cleanly and dried; the limits of detection were determined to be 800 nM and 29 ng/mL, respectively. Our proposed work therefore initiates the low-cost, high-performance biosensing using aluminum plasmonics, which would find wide applications in rapid diagnosis, mobile-healthcare and environmental monitoring.
authors.affiliation: Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Engineering, Sun Yat-sen University, Guangzhou 510006, China.
authors.forename: Wanbo
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, United States.
authors.forename: Yongcai
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Engineering, Sun Yat-sen University, Guangzhou 510006, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Engineering, Sun Yat-sen University, Guangzhou 510006, China.
authors.forename: Lelun
authors.initials: L
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Optoelectronic Materials and Technologies, School of Physics and Engineering, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Zhangkai
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Optoelectronic Materials and Technologies, School of Physics and Engineering, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Huanjun
authors.initials: H
authors.lastname: Chen
authors.affiliation: Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Engineering, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: zhoujh33@mail.sysu.edu.cn.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis* / Q000097:blood; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood; D006801:Humans; D007259:Infrared Rays; D008027:Light; D046228:Microarray Analysis / Q000379:methods; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis; D012031:Refractometry; D020349:Surface Plasmon Resonance / Q000379:methods*; D014466:Ultraviolet Rays
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C578959:carbohydrate antigen 199, human; D000535:Aluminum
keywords: Aluminum nanopyramid array; Biosensing; Cancer biomarker; Localized surface plasmon resonance; Ultraviolet–visible–infrared