title: In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol.
abstract: Recent studies have revealed the high cytotoxicity of p-menthane derivatives against human tumor cells. In this study, the substance perillaldehyde 8,9-epoxide, a p-menthane class derivative obtained from (S)-(-)-perillyl alcohol, was selected in order to assess antitumor activity against experimental sarcoma 180 tumors. Toxicological effects related to the liver, spleen, kidneys and hematology were evaluated in mice submitted to treatment. The tumor growth inhibition rate was 38.4%, 58.7%, 35.3%, 45.4% and 68.1% at doses of 100 and 200 mg/kg/day for perillaldehyde 8,9-epoxide, perillyl alcohol and 25 mg/kg/day for 5-FU intraperitoneal treatments, respectively. No toxicologically significant effect was found in liver and kidney parameters analyzed in Sarcoma 180-inoculated mice treated with perillaldehyde 8,9-epoxide. Histopathological analyses of the liver, spleen, and kidneys were free from any morphological changes in the organs of the animals treated with perillaldehyde 8,9-epoxide. In conclusion, the data suggest that perillaldehyde 8,9-epoxide possesses significant antitumor activity without systemic toxicity for the tested parameters. By comparison, there was no statistical difference for the antitumor activity between perillaldehyde 8,9-epoxide and perillyl alcohol.
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão, Sergipe CP 353, Brazil. lulisynalone@yahoo.com.br.
authors.forename: Luciana Nalone
authors.initials: LN
authors.lastname: Andrade
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão, Sergipe CP 353, Brazil. ricardoamaral23@hotmail.com.
authors.forename: Ricardo Guimarães
authors.initials: RG
authors.lastname: Amaral
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão, Sergipe CP 353, Brazil. gracedoria@hotmail.com.
authors.forename: Grace Anne Azevedo
authors.initials: GA
authors.lastname: Dória
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão, Sergipe CP 353, Brazil. cecilia_farma@hotmail.com.
authors.forename: Cecília Santos
authors.initials: CS
authors.lastname: Fonseca
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão, Sergipe CP 353, Brazil. tayane.kayane@yahoo.com.br.
authors.forename: Tayane Kayane Mariano
authors.initials: TK
authors.lastname: da Silva
authors.affiliation: Laboratório de Morfologia e Patologia Experimental, Instituto de Tecnologia e Pesquisa, CEP 49032-490, Aracaju, Sergipe CP 203, Brazil. ricardo.patologia@uol.com.br.
authors.forename: Ricardo Luiz Cavalcante
authors.initials: RL
authors.lastname: Albuquerque Júnior
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão, Sergipe CP 353, Brazil. sthomazzi@gmail.com.
authors.forename: Sara Maria
authors.initials: SM
authors.lastname: Thomazzi
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CEP 58051-970, João Pessoa, Paraíba CP 5009, Brazil. lazarofarm2@gmail.com.
authors.forename: Lázaro Gomes
authors.initials: LG
authors.lastname: do Nascimento
authors.affiliation: Núcleo de Farmácia, Universidade Federal de Sergipe, CEP 49400-000, Lagarto, Sergipe CP 353, Brazil. a.acarvalho@yahoo.com.br.
authors.forename: Adriana Andrade
authors.initials: AA
authors.lastname: Carvalho
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CEP 58051-970, João Pessoa, Paraíba CP 5009, Brazil. damiao_desousa@yahoo.com.br.
authors.forename: Damião Pergentino
authors.initials: DP
authors.lastname: de Sousa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D051379:Mice; D039821:Monoterpenes / Q000494:pharmacology*; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D039821:Monoterpenes; C000611748:perillaldehyde 8,9-epoxide; C032208:perillyl alcohol; D005472:Fluorouracil
keywords: anticancer; antitumor activity; essential oils; monoterpenes; natural products; p-menthanes; perillyl alcohol; sarcoma 180; toxicity