title: A Population-Based Assessment of 24-Hour Ocular Perfusion Pressure Among Patients With Primary Open Angle Glaucoma: The Handan Eye Study.
abstract: OBJECTIVE
  To compare the 24-hour ocular perfusion pressure (OPP) among patients with primary open angle glaucoma (POAG) and those with suspected POAG identified in a population-based study in China.
  
  
  METHODS
  Forty-seven patients with POAG and 35 with suspected POAG attended the 24-hour OPP study. Intraocular pressure (IOP) and blood pressure (BP) were measured at 2, 6, and 10 AM and 2, 6, and 10 PM. Subjects were not taking any medications to lower IOP, which was measured with Goldmann applanation in an upright sitting position. Blood pressure was measured in a supine position using a digital automatic BP monitor (OMRON, model HEM-907). Mean arterial pressure was calculated as diastolic BP + 1[Fraction Slash]3 × (systolic BP - diastolic BP). Mean OPP (MOPP) was defined as 2[Fraction Slash]3 × mean arterial pressure - IOP, systolic OPP (SOPP) was defined as 2[Fraction Slash]3 × systolic BP - IOP, and diastolic OPP (DOPP) was defined as 2[Fraction Slash]3 × diastolic BP - IOP.
  
  
  RESULTS
  After adjustment for age, sex, and IOP, the maximum, mean, and minimum SOPP, DOPP, and MOPP were statistically significantly lower in subjects with POAG than in those with suspected POAG (P < 0.05). The minimum MOPP, SOPP, and DOPP occurred from 10 AM to 2 PM in approximately 60% of eyes with POAG and between 20% and 30% of minimum MOPP, SOPP, and DOPP occurred around 10 PM.
  
  
  CONCLUSIONS
  Systolic OPP, DOPP, and MOPP were consistently lower in eyes with POAG than in those with suspected POAG, providing further evidence that OPP plays a role in the development of glaucoma.
authors.affiliation: From the *Clinical and Epidemiological Eye Research Center, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; †Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing, China; ‡Wilmer Eye Institute, Johns Hopkins University; §Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; and ¶Handan Eye Hospital, Handan, Hebei Province, China.
authors.forename: Yuan Bo
authors.initials: YB
authors.lastname: Liang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhou
authors.forename: David S
authors.initials: DS
authors.lastname: Friedman
authors.forename: Li Xia
authors.initials: LX
authors.lastname: Guo
authors.forename: Lan Ping
authors.initials: LP
authors.lastname: Sun
authors.forename: Qiu Feng
authors.initials: QF
authors.lastname: Zong
authors.forename: Xiao Dong
authors.initials: XD
authors.lastname: Yang
authors.forename: Ning Li
authors.initials: NL
authors.lastname: Wang
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology; D062186:Arterial Pressure / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002681:China; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D014065:Tonometry, Ocular
chemical_list: D000959:Antihypertensive Agents