title: Investigation of the relationship between salivary cortisol, dehydroepiandrosterone sulfate, anxiety, and depression in patients with hyperemesis gravidarum.
abstract: BACKGROUND
  The aim of this study was to determine the relationship of the salivary levels of dehydroepiandrosterone sulfate (DHEA-S) and cortisol with factors related to depression and anxiety in patients with hyperemesis gravidarum (HG).
  
  
  METHODS
  Forty patients with a diagnosis of HG were selected for the study and matched with 40 control patients according to body mass index, parity, and age. Symptoms of depression and anxiety were investigated using the Beck Depression Inventory and Beck Anxiety Inventory for Adults, respectively. Saliva samples were collected in the morning and at night and subjected to enzyme-linked immunosorbent assay for the determination of DHEA-S and cortisol levels.
  
  
  RESULTS
  We observed a positive correlation between increased levels of depression and anxiety and increased salivary levels of cortisol and DHEA-S in patients with HG.
  
  
  CONCLUSIONS
  Salivary cortisol and DHEA-S levels, as well as mood disorders, should be monitored in patients with HG, although further large, prospective studies are needed to confirm our results.
authors.affiliation: a Department of Obstetrics and Gynecology .
authors.forename: Esin
authors.initials: E
authors.lastname: Kasap
authors.affiliation: b Department of Psychiatry , Sifa University School of Medicine , İzmir , Turkey .
authors.forename: Ebru Emine
authors.initials: EE
authors.lastname: Aksu
authors.affiliation: a Department of Obstetrics and Gynecology .
authors.forename: Esra Bahar
authors.initials: EB
authors.lastname: Gur
authors.affiliation: a Department of Obstetrics and Gynecology .
authors.forename: Mine
authors.initials: M
authors.lastname: Genc
authors.affiliation: c Department of Obstetrics and Gynecology , Merkez Efendi State Hospital , Manisa , Turkey , and.
authors.forename: Fatma
authors.initials: F
authors.lastname: Eskicioğlu
authors.affiliation: d Department of Biochemistry , Sifa University School of Medicine , İzmir , Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Gökduman
authors.affiliation: a Department of Obstetrics and Gynecology .
authors.forename: Serkan
authors.initials: S
authors.lastname: Güçlü
mesh_terms: D000328:Adult; D001007:Anxiety / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism*; D003863:Depression / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D006939:Hyperemesis Gravidarum / Q000378:metabolism / Q000523:psychology*; D011247:Pregnancy; D011446:Prospective Studies; D012463:Saliva / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone
keywords: Anxiety; cortisol; dehydroepiandrosterone sulfate; depression; hyperemesis gravidarum