title: Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds.
abstract: Scrapie in goats is a transmissible, fatal prion disease, which is endemic in the British goat population. The recent success in defining caprine PRNP gene variants that provide resistance to experimental and natural classical scrapie has prompted the authors to conduct a survey of PRNP genotypes in 10 goat breeds and 52 herds to find goats with the resistant K222 allele. They report here the frequencies in 1236 tested animals of the resistance-associated K222 and several other alleles by breed and herd. Eight animals were found to be heterozygous QK222 goats (0.64 per cent genotype frequency, 95 per cent CI 0.28 to 1.27 per cent) but no homozygous KK222 goats were detected. The K222 allele was found in Saanen, Toggenburg and Anglo-Nubian goats. The fact that only a few goats with the K222 allele have been identified does not preclude the possibility to design and implement successful breeding programmes at national level.
authors.affiliation: The Roslin Institute and R(D)SVS University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
authors.forename: W
authors.initials: W
authors.lastname: Goldmann
authors.affiliation: Animal and Plant Health Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK.
authors.forename: E
authors.identifier: http://orcid.org/0000-0003-0187-3906
authors.initials: E
authors.lastname: Marier
authors.affiliation: The Roslin Institute and R(D)SVS University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
authors.forename: P
authors.initials: P
authors.lastname: Stewart
authors.affiliation: Animal and Plant Health Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK.
authors.forename: T
authors.initials: T
authors.lastname: Konold
authors.affiliation: Animal and Plant Health Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK.
authors.forename: S
authors.initials: S
authors.lastname: Street
authors.affiliation: Central Veterinary Institute part of Wageningen UR (CVI) Department of Infection Biology, P.O. Box 65, 8200 AB Lelystad, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Langeveld
authors.affiliation: Animal and Plant Health Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK.
authors.forename: O
authors.initials: O
authors.lastname: Windl
authors.affiliation: Animal and Plant Health Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK.
authors.forename: A
authors.initials: A
authors.lastname: Ortiz-Pelaez
mesh_terms: D000483:Alleles; D000818:Animals; D005838:Genotype; D015511:Goat Diseases / Q000235:genetics*; D006041:Goats; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics*; D012608:Scrapie / Q000235:genetics*; D011795:Surveys and Questionnaires; D006113:United Kingdom
chemical_list: D011328:Prions
keywords: Brain diseases; Gene polymorphisms; Goats; Prion protein; Resistance; Scrapie