title: Marine Pyridoacridine Alkaloids: Biosynthesis and Biological Activities.
abstract: Pyridoacridines are a class of strictly marine-derived alkaloids that constitute one of the largest chemical families of marine alkaloids. During the last few years, both natural pyridoacridines and their analogues have constituted excellent targets for synthetic works. They have been the subject of intense study due to their significant biological activities; cytotoxic, antibacterial, antifungal, antiviral, insecticidal, anti-HIV, and anti-parasitic activities. In the present review, 95 pyridoacridine alkaloids isolated from marine organisms are discussed in term of their occurrence, biosynthesis, biological activities, and structural assignment.
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah , Al Munawwarah 30078, Saudi Arabia (phone: +966-581-183034; fax:+966-484-75027). sabrinshaur@gmail.com.|Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt, (phone: +20-88-2411330; fax: +20-88-2332776). sabrinshaur@gmail.com.
authors.forename: Sabrin R M
authors.initials: SR
authors.lastname: Ibrahim
authors.affiliation: Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia (phone: +966-597-636182). gamals2001@yahoo.com.|Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt, (phone: +20-88-2181191; fax: +20-88-2181191). gamals2001@yahoo.com.
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mohamed
mesh_terms: D000166:Acridines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000470:Alkaloids / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000977:Antiparasitic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007306:Insecticides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015394:Molecular Structure; D010618:Phenanthrolines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000166:Acridines; D000470:Alkaloids; D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000977:Antiparasitic Agents; D007306:Insecticides; D010618:Phenanthrolines; C475900:pyridoacridine
keywords: Alkaloids; Ascidians; Biological activity; Biosynthesis; Pyridoacridine