title: Molecular Imaging of Chemokine Receptor CXCR4 in Non-Small Cell Lung Cancer Using 68Ga-Pentixafor PET/CT: Comparison With 18F-FDG.
abstract: We report the case of a 62-year-old woman with a history of ST-elevation myocardial infarction who underwent 68Ga-Pentixafor PET/CT for characterization of postinfarct myocardial inflammation. 68Ga-Pentixafor PET/CT incidentally demonstrated marked CXCR4 expression in a space-occupying lesion in the right upper lobe. Corresponding 18F-FDG PET/CT showed increased metabolism, and subsequent biopsy revealed non-small cell lung cancer. Immunohistochemistry confirmed that CXCR4 was highly expressed on tumor cells. 68Ga-Pentixafor is a novel CXCR4-targeted probe for PET imaging of CXCR4-positive tumors and holds promise for tumor staging and prognostic stratification. CXCR4-targeted radionuclide therapy represents a therapy option in metastasized diseases.
authors.affiliation: From the *Department of Nuclear Medicine; †Institute of Pathology; and ‡Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Derlin
authors.forename: Danny
authors.initials: D
authors.lastname: Jonigk
authors.forename: Johann
authors.initials: J
authors.lastname: Bauersachs
authors.forename: Frank M
authors.initials: FM
authors.lastname: Bengel
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging*; D056831:Coordination Complexes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008875:Middle Aged; D064847:Multimodal Imaging; D010456:Peptides, Cyclic; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: C000597686:68Ga-pentixafor; D056831:Coordination Complexes; D010456:Peptides, Cyclic; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18