title: Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents.
abstract: OBJECTIVE
  In this study, our aim was to determine cardiovascular risk and cardiac function in prediabetic obese children and adolescents.
  
  
  METHODS
  The study was conducted on 198 obese children and adolescents 6-18 years of age. Anthropometric measurements, blood pressure measurements, oral glucose tolerance test, lipid profile, and HbA1c levels of patients were assessed. Prediabetes was defined according to American Diabetes Association criteria. Left ventricular mass index (LVMi), carotid intima-media thickness (c-IMT), and tissue Doppler measurements records were used.
  
  
  RESULTS
  LVMi was found to be significantly higher in the prediabetes group (p=0.03). There were no statistically significant differences in right ventricular tissue Doppler measurements between the prediabetic and non-prediabetic groups. Left ventricular tissue Doppler measurements were significantly higher in the prediabetes group: LVEEM (left ventricular E/e ratio) (p=0.04); LVEM (left ventricular myocardial velocity cm/s) (p=0.035). LVMi was found to positively correlate with triglyceride level, diastolic blood pressure, waist circumference, body weight standard deviation score and to negatively correlate with high-density lipoprotein cholesterol (p=0.043, r=0.15; p=0.039, r=0.15; p=0.025, r=0.17; p=0.009, r=0.19; p=0.038, r=-0.15, respectively). LVEM was correlated with glucose (p=0.046, r=0.15) and LVEEM was correlated with systolic blood pressure (p=0.035, r=0.15). In linear regression analysis for clinical cardiovascular risk factors, fasting glucose level was the best predictor of LVEM.
  
  
  CONCLUSIONS
  In this study, deterioration of cardiac function in prediabetic obese children and adolescents was shown. We recommend determining cardiovascular risk and cardiac dysfunction at early stages in prediabetic obese children and adolescents.
authors.affiliation: Necmettin Erbakan University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, Konya, Turkey, E-mail: berayselver@hotmail.com.
authors.forename: Beray Selver
authors.initials: BS
authors.lastname: Eklioğlu
authors.forename: Mehmet Emre
authors.initials: ME
authors.lastname: Atabek
authors.forename: Nesibe
authors.initials: N
authors.lastname: Akyürek
authors.forename: Hayrullah
authors.initials: H
authors.lastname: Alp
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D002648:Child; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D011236:Prediabetic State / Q000150:complications* / Q000503:physiopathology; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers