title: Adjuvant systemic chemotherapy with or without bevacizumab in patients with resected pulmonary metastases from colorectal cancer.
abstract: BACKGROUND
  We investigated the impact of modern chemotherapy regimens and bevacizumab following pulmonary metastasectomy (PM) from metastatic colorectal cancer (CRC).
  
  
  METHODS
  A total of 122 consecutive patients who were curatively resected for pulmonary metastases of CRC in twelve oncology centers were retrospectively analysed between January 2000 and April 2012.
  
  
  RESULTS
  Of 122 patients, 14 did not receive any treatment following PM. The remaining 108 patients received fluoropyrimidine-based (n = 12), irinotecan-based (n = 56) and oxaliplatin-based (n = 40) chemotherapy combinations. Among these, 52 patients received bevacizumab (BEV) while 56 did not (NoBEV). Median recurrence-free survival (RFS) was 17 months and median overall survival (OS) has not been reached at a median follow-up of 25 months after PM. Three and five-year OS rates were 66% and 53%, respectively. RFS and OS were similar, irrespective of the chemotherapy regimen or BEV use. Positive pulmonary margin, KRAS mutation status, and previous liver metastasectomy were negative independent prognostic factors for RFS, while pathologically confirmed thoracic lymph node involvement was the only negative independent prognostic for OS in multivariate analysis.
  
  
  CONCLUSIONS
  No significant RFS or OS difference was observed in respect to chemotherapy regimens with or without BEV in patients with pulmonary metastases of CRC following curative resection.
authors.affiliation: Department of Medical Oncology, Malatya State Hospital Malatya, Turkey.
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authors.lastname: Turan
authors.affiliation: Department of Medical Oncology, Gazi University Faculty of Medicine Ankara, Turkey.
authors.forename: Mustafa
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authors.lastname: Benekli
authors.affiliation: Department of Medical Oncology, Marmara University Faculty of Medicine Istanbul, Turkey.
authors.forename: Faysal
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authors.lastname: Dane
authors.affiliation: Department of Medical Oncology, Dokuz Eylül University Faculty of Medicine Izmir, Turkey.
authors.forename: Olcun Umit
authors.initials: OU
authors.lastname: Unal
authors.affiliation: Department of Thoracic Surgery, Marmara University Faculty of Medicine Istanbul, Turkey.
authors.forename: Hasan Volkan
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authors.affiliation: Department of Medical Oncology, Regional Training and Research Hospital Van, Turkey.
authors.forename: Dogan
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authors.affiliation: Department of Medical Oncology, Dr Lutfi Kirdar Kartal Education and Research Hospital Istanbul, Turkey.
authors.forename: Ozlem
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authors.affiliation: Department of Medical Oncology, Numune Education and Research Hospital Ankara, Turkey.
authors.forename: Tulay
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authors.lastname: Eren
authors.affiliation: Department of Medical Oncology, Necmettin Erbakan University Faculty of Medicine Konya, Turkey.
authors.forename: Didem
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authors.affiliation: Department of Medical Oncology, Dr Abdurrahman Yurtaslan Education and Research Hospital Ankara, Turkey.
authors.forename: Kaan
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authors.affiliation: Department of Medical Oncology, Erciyes University Faculty of Medicine Kayseri, Turkey.
authors.forename: Veli
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authors.lastname: Berk
authors.affiliation: Department of Medical Oncology, Dr Abdurrahman Yurtaslan Education and Research Hospital Ankara, Turkey.
authors.forename: Umut
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authors.lastname: Demirci
authors.affiliation: Department of Medical Oncology, Adıyaman University Education and Research Hospital Adıyaman, Turkey.
authors.forename: Selcuk Cemil
authors.initials: SC
authors.lastname: Ozturk
authors.affiliation: Department of Medical Oncology, Regional Training and Research Hospital Van, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Dogan
authors.affiliation: Department of Medical Oncology, Regional Training and Research Hospital Van, Turkey.
authors.forename: Bulent
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authors.lastname: Cetin
authors.affiliation: Department of Medical Oncology, Dicle University Faculty of Medicine Diyarbakir, Turkey.
authors.forename: Mehmet
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authors.lastname: Kucukoner
authors.affiliation: Department of Medical Oncology, Antakya State Hospital Hatay, Turkey.
authors.forename: Onder
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authors.lastname: Tonyali
authors.affiliation: Department of Medical Oncology, Rize Education and Research Hospital Rize, Turkey.
authors.forename: Gulnihal
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authors.lastname: Tufan
authors.affiliation: Department of Medical Oncology, Dokuz Eylül University Faculty of Medicine Izmir, Turkey.
authors.forename: Ilhan
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authors.affiliation: Department of Medical Oncology, Dr Lutfi Kirdar Kartal Education and Research Hospital Istanbul, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gumus
authors.affiliation: Department of Medical Oncology, Gazi University Faculty of Medicine Ankara, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Coskun
authors.affiliation: Department of Medical Oncology, Gazi University Faculty of Medicine Ankara, Turkey.
authors.forename: Aytug
authors.initials: A
authors.lastname: Uner
authors.affiliation: Department of Medical Oncology, Gazi University Faculty of Medicine Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozet
authors.affiliation: Department of Medical Oncology, Gazi University Faculty of Medicine Ankara, Turkey.
authors.forename: Suleyman
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authors.lastname: Buyukberber
keywords: Adjuvant chemotherapy; bevacizumab; colorectal cancer; pulmonary metastasectomy