title: Clinical Outcomes of Endoscopic Ultrasonography-Guided Pancreatic Cyst Ablation.
abstract: Endoscopic ultrasonography-guided ethanol ablation therapy for pancreatic cystic lesions is a minimally invasive treatment but still is an experimental therapy. The aims were to investigate the safety and efficacy of endoscopic ultrasonography-guided ethanol ablation therapy.
  
  
  
  The inclusion criteria were the following: clinically indeterminate pancreatic cystic lesions in radiologic imaging studies, 2 to 5 cm unilocular or oligolocular cysts without communication to main pancreatic duct, and patients with high-risk operation.
  
  
  
  There were 91 study patients with median follow-up of 40 months. The response rate was as follows: complete resolution, 41 (45%); partial resolution, 37; and persistent cysts, 13. Pancreatic cystic lesions were categorized based on cystic fluid analysis: 9 intraductal papillary mucinous neoplasms (IPMNs), 12 mucinous cystic neoplasms, 33 serous cystic neoplasms, and 28 uncategorized cysts. The success rate was significantly different according to cystic fluid analysis (serous cystic neoplasm, 58%; mucinous cystic neoplasm, 50%; IPMN, 11%; uncategorized cysts, 39%; P < 0.0001). There were 3 patients with mild pancreatitis after the treatment.
  
  
  
  Endoscopic ultrasonography-guided ethanol ablation therapy seems to be a safe treatment modality. However, it was only effective in 11% of IPMNs. Therefore, the clinical application should be very limited for certain patients who could not tolerate the surgical treatment.
authors.affiliation: From the *Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; †Myongji Hospital, Goyang, Gyeonggi; ‡Division of Gastroenterology, Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Joo Kyung
authors.initials: JK
authors.lastname: Park
authors.forename: Byeong Jun
authors.initials: BJ
authors.lastname: Song
authors.forename: Ji Kon
authors.initials: JK
authors.lastname: Ryu
authors.forename: Woo Hyun
authors.initials: WH
authors.lastname: Paik
authors.forename: Jin Myung
authors.initials: JM
authors.lastname: Park
authors.forename: Jaihwan
authors.initials: J
authors.lastname: Kim
authors.forename: Sang Hyub
authors.initials: SH
authors.lastname: Lee
authors.forename: Yong-Tae
authors.initials: YT
authors.lastname: Kim
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D002288:Adenocarcinoma, Mucinous / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000601:surgery; D002291:Carcinoma, Papillary / Q000601:surgery; D020420:Cyst Fluid / Q000737:chemistry; D019160:Endosonography / Q000379:methods*; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010181:Pancreatic Cyst / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000601:surgery; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000431:Ethanol