title: Stem cells as cellular vehicles for gene therapy against glioblastoma.
abstract: Glioblastoma (GBM) is the most common and deadliest primary tumor in adults, with current treatments having limited specific and efficient delivery of therapeutic drugs to tumor sites or cells. Therefore, the development of alternative treatment options is urgently needed. Stem cells are considered as ideal cellular vehicles for gene therapy against glioblastoma. In this paper, we reviewed the recent studies investigating the use of different types of stem cells as cellular vehicles and the gene of interests against the glioblastoma, as well as the future directions of the application of cellular vehicles mediated therapy for glioblastoma.
authors.affiliation: Clinical Research Institute, Zhejiang Provincial People's HospitalHangzhou 310014, China; Department of Orthopaedics, The Second Affiliated Hospital, School of Medicine, Zhejiang UniversityHangzhou 310009, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Anus, Rectum & Colon Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou 310003, China.
authors.forename: Fanlong
authors.initials: F
authors.lastname: Liu
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou 310003, China.
authors.forename: Bingyu
authors.initials: B
authors.lastname: Xiang
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou 310003, China.
authors.forename: Charlie
authors.initials: C
authors.lastname: Xiang
authors.affiliation: Clinical Research Institute, Zhejiang Provincial People's Hospital Hangzhou 310014, China.
authors.forename: Xiaozhou
authors.initials: X
authors.lastname: Mou
keywords: Glioma; cellular vehicle; gene therapy; stem cell