title: Computer Simulation and Analysis on Flow Characteristics and Distribution Patterns of Polymethylmethacrylate in Lumbar Vertebral Body and Vertebral Pedicle.
abstract: This study was designed to analyze the flow and distribution of polymethylmethacrylate (PMMA) in vertebral body through computer simulation. Cadaveric lumbar vertebrae were scanned through electron beam tomography (EBT). The data was imported into Mimics software to build computational model. Vertebral body center and junction of pedicle and vertebral body were chosen as injection points. Silicone oil with viscosity of 100,000 cSt matching with PMMA bone cement was chosen for injection. The flow and distribution of silicone oil were analyzed using Fluent software. In vertebral body, silicone oil formed a circle-like shape centered by injection point on transverse and longitudinal sections, finally forming a sphere-like shape as a whole. Silicone oil diffused along lateral and posterior walls forming a circle-like shape on transverse section centered by injection point in pedicle, eventually forming a sphere-like shape as a whole. This study demonstrated that silicone oil flowed and diffused into a circle-like shape centered by injection point and finally formed a sphere-like shape as a whole in both vertebral body and pedicle. The flow and distribution of silicon oil in computational model could simulate PMMA distribution in vertebral body. It may provide theoretical evidence to reduce PMMA leakage risk during percutaneous vertebroplasty.
authors.affiliation: Department of Orthopaedics, Chengdu Military General Hospital, No. 270, Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: Da
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics, Naval Hospital, No. 6, Mazhang District, Zhanjiang, Guangdong 524096, China.
authors.forename: Xu-Li
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics, Chengdu Military General Hospital, No. 270, Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, Chengdu Military General Hospital, No. 270, Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: Dong-Fa
authors.initials: DF
authors.lastname: Liao
authors.affiliation: Department of Orthopaedics, Chengdu Military General Hospital, No. 270, Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, Hospital of Nanjing Military Region, No. 4, Hudong Street, Yingtan, Jiangxi 335000, China.
authors.forename: Jiang-Jun
authors.initials: JJ
authors.lastname: Zhou
authors.affiliation: Department of Orthopaedics, Chengdu Military General Hospital, No. 270, Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Kang
authors.affiliation: Department of Orthopaedics, Chengdu Military General Hospital, No. 270, Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, No. 15, Changle West Road, Xi'an, Shaanxi 710032, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lei
mesh_terms: D001843:Bone Cements / Q000627:therapeutic use*; D002102:Cadaver; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000473:pathology; D019904:Polymethyl Methacrylate / Q000008:administration & dosage*; D012827:Silicone Oils / Q000008:administration & dosage; D016103:Spinal Fractures / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D001843:Bone Cements; D012827:Silicone Oils; D019904:Polymethyl Methacrylate