title: Preventive effects of raloxifene treatment on agerelated weight loss in postmenopausal women.
abstract: Decline of body weight and body mass index (BMI) with aging is a major risk factor for osteoporosis and fracture, suggesting that treatment for osteoporosis may affect body composition. However, the effects of treatment for osteoporosis on body composition are not well known. The present study aimed to identify the relationship between raloxifene treatment and body composition markers. We measured bone mineral density (BMD), body composition, and bone remodeling markers in 236 Japanese postmenopausal women with raloxifene treatment (N = 50) and without treatment by any osteoporosis drug (N = 186) for 5 years and analyzed the relationship of these with BMD, BMI, body weight, and biochemical markers. The mean (SD) age of the participants was 65.5 (9.3) years. Percent-changes in body weight and BMI were significantly different between women taking raloxifene and those not taking any osteoporosis drugs (P = 0.03 and 0.048, respectively). Raloxifene treatment was a significant independent determinant of body weight and BMI. Long-term treatment with raloxifene prevents age-related weight loss.
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bumkyo-ku, Tokyo, 113-8655, Japan.|Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Urano
authors.affiliation: Research Institute and Practice for Involutional Diseases, Nagano, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Shiraki
authors.affiliation: Public Health Research Foundation, Tokyo, Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kuroda
authors.affiliation: Division of Clinical Trial, Design and Management, Translational Research Center, Kyoto University, Kyoto, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Division of Nutritional Physiology, Kagawa University, 3-9-21 Chiyoda, Sakaido, Saitama, 350-0288, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Uenishi
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bumkyo-ku, Tokyo, 113-8655, Japan. INOUE-GER@h.u-tokyo.ac.jp.|Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan. INOUE-GER@h.u-tokyo.ac.jp.|Research Center for Genomic Medicine, Saitama Medical School, Saitama, 350-1241, Japan. INOUE-GER@h.u-tokyo.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000188:drug therapy; D017698:Postmenopause / Q000097:blood*; D020849:Raloxifene Hydrochloride / Q000008:administration & dosage*; D012189:Retrospective Studies; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D015415:Biomarkers; D020849:Raloxifene Hydrochloride
keywords: Body mass index; Body weight; Long term treatment; Raloxifene