title: Association of N-Methyl-D-Aspartate receptor 2B Subunit (GRIN2B) polymorphism with earlier age at onset of withdrawal symptoms in Indian alcohol dependent subjects.
abstract: The associations of GRIN2B polymorphism (rs1806201) with alcohol withdrawal and related clinical parameters in alcohol dependent subjects were investigated. Cases were assessed using a semi-structured clinical pro forma for alcohol abuse and a questionnaire for family history of alcohol dependence and psychiatric disorders after obtaining informed consent. The study included alcohol dependent male cases (n = 220, age at onset of alcohol withdrawal symptoms = 32.4 ± 8.8 y) recruited at the Center for Addiction Medicine, National Institute of Mental Health and Neurosciences, Bangalore, India. The controls comprised of healthy unrelated males (n = 183) who were ethnically matched and selected randomly. The polymorphism rs1806201 was analyzed by polymerase chain reaction and restriction fragment length polymorphism. The presence of T allele at this locus was significantly associated with lower age at onset of alcohol withdrawal symptoms (p = .005) among the cases. Mean age at onset of alcohol withdrawal symptoms in subjects who were T carriers was 31.4 ± 8.5 y (n = 160) and non-T carriers was 35.2 ± 9.0 y (n = 60). The SNP rs1806201 in GRIN2B may play an important role in genetic susceptibility to earlier age of withdrawal in alcohol dependent patients.
authors.affiliation: a Molecular Genetics Laboratory, Neurobiology Research Centre, Department of Psychiatry , National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
authors.forename: Pradip
authors.initials: P
authors.lastname: Paul
authors.affiliation: b Department of Psychiatry , National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
authors.forename: Ajit
authors.initials: A
authors.lastname: Dahale
authors.affiliation: c Mid-West Area Mental Health Service , North Western Mental Health, Melbourne Health , Victoria , Australia.
authors.forename: Brij
authors.initials: B
authors.lastname: Kishore
authors.affiliation: d Center for Addiction Medicine, Department of Psychiatry , National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
authors.forename: Prabhat
authors.initials: P
authors.lastname: Chand
authors.affiliation: d Center for Addiction Medicine, Department of Psychiatry , National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Benegal
authors.affiliation: a Molecular Genetics Laboratory, Neurobiology Research Centre, Department of Psychiatry , National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Jain
authors.affiliation: d Center for Addiction Medicine, Department of Psychiatry , National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
authors.forename: Pratima
authors.initials: P
authors.lastname: Murthy
authors.affiliation: a Molecular Genetics Laboratory, Neurobiology Research Centre, Department of Psychiatry , National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
authors.forename: Meera
authors.initials: M
authors.lastname: Purushottam
mesh_terms: D000328:Adult; D017668:Age of Onset; D000437:Alcoholism / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*; D013375:Substance Withdrawal Syndrome / Q000235:genetics*
chemical_list: C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Alcohol dependence; N-Methyl-D-Aspartate receptor (GRIN2B); glutamate; polymorphism; rs1806201; withdrawal