title: Effect analysis of early bedside hemo-filtration in treatment of severe pneumonia with acute renal failure of children.
abstract: OBJECTIVE
  To investigate the best opportunity for bedside continuous blood purification (CBP) to treat severe pneumonia with acute renal failure (ARF) of children and look for the sensitive marker to evaluate the clinical effects and prognosis.
  
  
  METHODS
  54 children patients that were diagnosed as severe pneumonia with ARF by Pediatric Intensive Care Unit (PICU) were enrolled in our study as experimental group. In the meanwhile, 46 children patients that were diagnosed as severe pneumonia with ARF by PICU were enrolled as a normal control group. Patients in the experimental group started CBP treatment within 24 h after onset while patients in the control group started CBP treatment 24h after onset. The differences of clinical effects between two groups were compared for statistical significance.
  
  
  RESULTS
  The survival rates of the observation group in day 7, day 28 and 6 months were significantly higher than those in the control group. After treatment for 7 days, IL-6 and TNF-α, YKL-40 and Annexin A1 levels of the experimental group were significantly lower than those of the control group. 7-day infection-related organ failure score (SOFA) of the experimental group was significantly lower than that of the control group.
  
  
  CONCLUSIONS
  CBP therapy for treating severe pneumonia with acute renal failure of children within 24 hours could significantly improve the survival rate and reduce the inflammatory reactions.
authors.affiliation: Intensive Care Unit, Xuzhou Children's Hospital, Xuzhou, Jiangsu, China. liweihua1975@126.com.
authors.forename: G-J
authors.initials: GJ
authors.lastname: Qi
authors.forename: Y-L
authors.initials: YL
authors.lastname: Chao
authors.forename: X-Y
authors.initials: XY
authors.lastname: Xi
authors.forename: K-X
authors.initials: KX
authors.lastname: Liu
authors.forename: W-H
authors.initials: WH
authors.lastname: Li
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000401:mortality / Q000628:therapy*; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006440:Hemofiltration; D006801:Humans; D015278:Intensive Care Units, Pediatric; D008297:Male; D011014:Pneumonia / Q000150:complications*; D019095:Point-of-Care Systems; D011379:Prognosis; D012720:Severity of Illness Index; D016019:Survival Analysis