title: Innate myeloid cells under the control of adaptive immunity: the example of mast cells and basophils.
abstract: Mast cells and basophils are mostly known as the initiators of IgE-dependent allergic reactions. They, however, contribute to innate immunity against pathogens and venoms. Like other myeloid cells, they also express receptors for the Fc portion of IgG antibodies. These include activating receptors and inhibitory receptors. Because IgG antibodies are produced in exceedingly higher amounts than IgE antibodies, IgG receptors are co-engaged with IgE receptors under physiological conditions. Mast cells and basophils are examples of the many innate myeloid cells whose effector functions are used and finely tuned by antibodies. They can be thus enrolled in a variety of adaptive immune responses, their activation can be regulated, positively and negatively and their biological responses can be modulated qualitatively by antibodies.
authors.affiliation: Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France; Centre d'immunologie de Marseille-Luminy, Université Aix Marseille UM2, Inserm U1104, CNRS UMR7280, 13288 Marseille, France. Electronic address: daeron@pasteur.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Daëron
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D017951:Antigen Presentation; D001491:Basophils / Q000166:cytology / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D007113:Immunity, Innate; D007073:Immunoglobulin E / Q000235:genetics; D007074:Immunoglobulin G / Q000235:genetics; D008407:Mast Cells / Q000166:cytology / Q000276:immunology; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D017455:Receptors, IgE / Q000235:genetics / Q000276:immunology*; D017452:Receptors, IgG / Q000235:genetics / Q000276:immunology*; D017206:Strongylida Infections / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D007074:Immunoglobulin G; D017455:Receptors, IgE; D017452:Receptors, IgG; D007073:Immunoglobulin E