title: Bromomethyllithium-mediated chemoselective homologation of disulfides to dithioacetals.
abstract: An efficient, chemoselective homologation of disulfides and diselenides to the corresponding dithio- and diselenoacetals has been developed via the addition of bromomethyllithium. Chemoselectivity is fully preserved in the presence of concomitant electrophilic sites decorating the substrates. The synthetic potential of selected dithioacetals has been evaluated in Feringa-Fañanas-Mastral-type Pd-catalyzed coupling with an organolithium and in the unusual 1,4-addition to a Weinreb amide.
authors.affiliation: University of Vienna - Department of Pharmaceutical Chemistry, Althanstrasse, 14. A-1090, Vienna, Austria. vittorio.pace@univie.ac.at.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Pace
authors.forename: Azzurra
authors.initials: A
authors.lastname: Pelosi
authors.forename: Daniele
authors.initials: D
authors.lastname: Antermite
authors.forename: Ornelio
authors.initials: O
authors.lastname: Rosati
authors.forename: Massimo
authors.initials: M
authors.lastname: Curini
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Holzer