title: Cardiovascular disease risks in adult Native and Mexican Americans with a history of alcohol use disorders: association with cardiovascular autonomic control.
abstract: Hypertension and obesity are serious health problems that have been associated with an increased risk of cardiovascular disease (CVD). We recently showed a relationship between hypertension, obesity and cardiovagal control in a sample of Native and Mexican Americans at high risk of alcohol use disorders (AUD). While studies have shown that Native and Mexican Americans exhibit high rates of AUD, the consequences of AUD on CVD risk factors and their relationship with cardiovascular autonomic control is not well understood in these ethnic groups. This study investigated whether an association could be demonstrated between cardiovascular autonomic control and several CVD risk factors in Native and Mexican American men and women (n = 228) who are literate in English and are residing legally in San Diego County. Participants with lifetime history of AUD showed higher rates of systolic and diastolic hypertension and obesity than participants without lifetime AUD. Lifetime AUD was significantly associated with reduced HR response to deep breathing (HRDB) measure of cardiovagal control, higher current drinking quantity, and obesity. Reduced HRDB was also associated with increased systolic pre-hypertension or hypertension (pre-/hypertension) and with higher diastolic blood pressure in a linear regression model that included several diagnostic and demographic variables. HRDB and time- and frequency-domain measures of cardiovagal control were significantly reduced in participants with diastolic pre-/hypertension. These data suggest that lower cardiovagal control may play a role in the prevalence of systolic and diastolic pre-/hypertension in a community sample with a history of alcohol and substance use disorders.
authors.affiliation: Scripps Autonomic Neuro Lab, Division of Neurology, Scripps Clinic, 10666 North Torrey Pines Rd., MS-313, La Jolla, CA, 92037, USA. criado.jose@scrippshealth.org.|Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA. criado.jose@scrippshealth.org.
authors.forename: José R
authors.initials: JR
authors.lastname: Criado
authors.affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Gilder
authors.affiliation: Scripps Autonomic Neuro Lab, Division of Neurology, Scripps Clinic, 10666 North Torrey Pines Rd., MS-313, La Jolla, CA, 92037, USA.|Division of Neurology, Stroke Center, Scripps Clinic, Green Hospital, La Jolla, CA, 92037, USA.
authors.forename: Mary A
authors.initials: MA
authors.lastname: Kalafut
authors.affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Ehlers
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000503:physiopathology*; D001341:Autonomic Nervous System / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000150:complications / Q000503:physiopathology*; D002320:Cardiovascular Physiological Phenomena; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D007198:Indians, North American; D008297:Male; D017058:Mexican Americans; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D012307:Risk Factors; D055815:Young Adult
keywords: Alcohol use disorders; Autonomic nervous system; Hypertension; Mexican Americans; Native Americans; Obesity