title: The effect of vitamin D on thyroid autoimmunity in non-lactating women with postpartum thyroiditis.
abstract: The study included 38 non-lactating l-thyroxine-treated women with postpartum thyroiditis (PPT) and 21 matched healthy postpartum women. Women with vitamin D deficiency were treated with oral vitamin D (4000 IU daily), whereas women with vitamin D insufficiency and women with normal 25-hydroxy vitamin levels were either treated with vitamin D (2000 IU daily) or left untreated. Serum hormone levels and thyroid antibody titers were measured at the beginning of the study and 3 months later. 25-hydroxy vitamin D levels were lower in women with PPT than in healthy women. Thyroid peroxidase and thyroglobulin antibody titers inversely correlated with vitamin D status. Apart from increasing serum levels of 25-hydroxy vitamin D and decreasing serum levels of parathyroid hormone, vitamin D reduced titers of thyroid peroxidase antibodies and this effect was stronger in women with vitamin D deficiency. The study's results suggest that vitamin D supplementation may bring benefits to l-thyroxine-treated women with PPT.
authors.affiliation: Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Krysiak
authors.affiliation: Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Kowalcze
authors.affiliation: Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Okopien
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D016022:Case-Control Studies; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D010281:Parathyroid Hormone / Q000097:blood; D050032:Postpartum Thyroiditis / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D013974:Thyroxine / Q000627:therapeutic use; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000276:immunology*; D014808:Vitamin D Deficiency / Q000097:blood / Q000276:immunology* / Q000628:therapy; D014815:Vitamins / Q000008:administration & dosage / Q000276:immunology*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D010281:Parathyroid Hormone; D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D007453:Iodide Peroxidase; D013974:Thyroxine