title: The role of HIF in immunity and inflammation.
abstract: Uncontrolled or non-resolving inflammation underpins a range of disease states including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Hypoxia is a prominent feature of chronically inflamed tissues. This is due to elevated oxygen consumption by highly metabolically active inflamed resident cells and activated infiltrating immunocytes, as well as diminished oxygen supply due to vascular dysfunction. Tissue hypoxia can have a significant impact upon inflammatory signaling pathways in immune and non-immune cells and this can impact upon disease progression. In this review, we will discuss the relationship between tissue hypoxia and inflammation and identify how hypoxia-sensitive signaling pathways are potential therapeutic targets in chronic inflammatory disease.
authors.affiliation: School of Medicine and Medical Science & The Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Eoin P
authors.initials: EP
authors.lastname: Cummins
authors.affiliation: School of Medicine and Medical Science & The Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Ciara E
authors.initials: CE
authors.lastname: Keogh
authors.affiliation: School of Medicine and Medical Science & The Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Crean
authors.affiliation: School of Medicine and Medical Science & The Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: cormac.taylor@ucd.ie.
authors.forename: Cormac T
authors.initials: CT
authors.lastname: Taylor
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D006801:Humans; D000860:Hypoxia / Q000276:immunology; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000378:metabolism*; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000628:therapy; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051793:Hypoxia-Inducible Factor 1; D016328:NF-kappa B
keywords: Hypoxia; hypoxia inducible factor; inflammation; leukocyte