title: Myriad Functions of Stanniocalcin-1 (STC1) Cover Multiple Therapeutic Targets in the Complicated Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF).
abstract: Idiopathic pulmonary fibrosis (IPF) is an intractable disease for which the pathological findings are characterized by temporal and spatial heterogeneity. The pathogenesis is composed of myriad factors, including repetitive injuries to epithelial cells, alterations in immunity, the formation of vascular leakage and coagulation, abnormal wound healing, fibrogenesis, and collagen accumulation. Therefore, the molecular target drugs that are used or attempted for treatment or clinical trials may not cover the myriad therapeutic targets of IPF. In addition, the complicated pathogenesis results in a lack of informative biomarkers to diagnose accurately the status of IPF. These facts point out the necessity of using a combination of drugs, that is, each single drug with molecular targets or a single drug with multiple therapeutic targets. In this review, we introduce a humoral factor, stanniocalcin-1 (STC1), which has myriad functions, including the maintenance of calcium homeostasis, the promotion of early wound healing, uncoupling respiration (aerobic glycolysis), reepithelialization in damaged tissues, the inhibition of vascular leakage, and the regulation of macrophage functions to keep epithelial and endothelial homeostasis, which may adequately cover the myriad therapeutic targets of IPF.
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan; Department of Occupational Health, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Ohkouchi
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Ono
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Taizou
authors.initials: T
authors.lastname: Hirano
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tojo
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, NY, USA; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Shu
authors.initials: S
authors.lastname: Hisata
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ichinose
authors.affiliation: Department of Occupational Health, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Irokawa
authors.affiliation: Department of Occupational Health, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ogawa
authors.affiliation: Department of Occupational Health, Graduate School of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Kurosawa
keywords: biomarker; idiopathic pulmonary fibrosis (IPF); macrophage; stanniocalcin-1 (STC1); wound healing