title: Effects of Low-Intensity Pulsed Ultrasound on Orthodontic Tooth Movement and Orthodontically Induced Inflammatory Root Resorption in Ovariectomized Osteoporotic Rats.
abstract: This study investigated the effects of low-intensity pulsed ultrasound (LIPUS) on orthodontic tooth movement (OTM) and orthodontically induced inflammatory root resorption (OIRR) in ovariectomized osteoporotic rats. Forty-eight 28-d-old female Wistar rats were divided into ovariectomized and intact groups. In both groups, animals were left untreated; treated with 50 g mesially directed orthodontic force on the maxillary first molars using nickel-titanium closed-coil springs for 28 d; or treated with the same orthodontic protocol along with a 20-min LIPUS application on alternate days for 28 d. Extent of OTM and amount of OIRR of mesial roots were measured on three-dimensionally reconstructed micro-computed tomography images. Ovariectomy increased OIRR (p < 0.05). LIPUS reduced root volumetric loss regardless of ovariectomy status (p < 0.05); only ovariectomized animals had decreased OTM (p < 0.05). LIPUS normalizes OTM and attenuates OIRR in ovariectomized osteoporotic rats. It may therefore be beneficial in women with postmenopausal osteoporosis.
authors.affiliation: Department of Orthodontics, School of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Feras Y
authors.initials: FY
authors.lastname: Dahhas
authors.affiliation: Department of Orthodontics and Biomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Tarek
authors.initials: T
authors.lastname: El-Bialy
authors.affiliation: Department of Orthodontics, School of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Ahmed R
authors.initials: AR
authors.lastname: Afify
authors.affiliation: Department of Orthodontics, School of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: aakbr@kau.edu.sa.
authors.forename: Ali H
authors.initials: AH
authors.lastname: Hassan
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D010024:Osteoporosis / Q000150:complications*; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D012391:Root Resorption / Q000209:etiology* / Q000628:therapy*; D014087:Tooth Movement Techniques / Q000009:adverse effects* / Q000379:methods*; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*
keywords: Inflammatory root resorption; Low-intensity pulsed ultrasound; Menopause; Micro-computed tomography; Orthodontic force; Osteoporosis; Tooth movement