title: Innate Immunity and BK Virus: Prospective Strategies.
abstract: Recent information demonstrated that BK virus reactivation is a dominant complication after kidney transplantation, which occurs because of immunosuppression. BK virus reactivation is the main reason of transplanted kidney losing. Immune response against BK virus is the major inhibitor of the virus reactivation. Therefore, improving our knowledge regarding the main parameters that fight against BK viruses can shed light on to direct new treatment strategies to suppress BK infection. Innate immunity consists of numerous cell systems and also soluble molecules, which not only suppress virus replication, but also activate adaptive immunity to eradicate the infection. Additionally, it appears that immune responses against reactivated BK virus are the main reasons for induction of BK virus-associated nephropathy (BKAN). Thus, improving our knowledge regarding the parameters and detailed mechanisms of innate immunity and also the status of innate immunity of the patients with BK virus reactivation and its complications can introduce new prospective strategies to either prevent or as therapy of the complication. Therefore, this review was aimed to collate the most recent data regarding the roles played by innate immunity against BK virus and also the status of innate immunity in the patients with reactivation BK virus and BKAN.
authors.affiliation: 1 Shiraz Branch, Department of Microbiology, Islamic Azad University , Shiraz, Iran .|2 Fars Research and Science Branch, Department of Microbiology, Islamic Azad University , Fars, Iran .
authors.forename: Ashraf
authors.initials: A
authors.lastname: Kariminik
authors.affiliation: 3 Shiraz Transplant Research Center, Shiraz University of Medical Sciences , Shiraz, Iran .
authors.forename: Ramin
authors.initials: R
authors.lastname: Yaghobi
authors.affiliation: 4 Pathology and Stem Cell Research Center, Department of Pathology, Afzalipour School of Medicine, Kerman University of Medical Sciences , Kerman, Iran .
authors.forename: Shahriar
authors.initials: S
authors.lastname: Dabiri
mesh_terms: D001739:BK Virus / Q000276:immunology* / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D027601:Polyomavirus Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology; D014775:Virus Activation; D017735:Virus Latency