title: A Probabilistic Atlas of Diffuse WHO Grade II Glioma Locations in the Brain.
abstract: Diffuse WHO grade II gliomas are diffusively infiltrative brain tumors characterized by an unavoidable anaplastic transformation. Their management is strongly dependent on their location in the brain due to interactions with functional regions and potential differences in molecular biology. In this paper, we present the construction of a probabilistic atlas mapping the preferential locations of diffuse WHO grade II gliomas in the brain. This is carried out through a sparse graph whose nodes correspond to clusters of tumors clustered together based on their spatial proximity. The interest of such an atlas is illustrated via two applications. The first one correlates tumor location with the patient's age via a statistical analysis, highlighting the interest of the atlas for studying the origins and behavior of the tumors. The second exploits the fact that the tumors have preferential locations for automatic segmentation. Through a coupled decomposed Markov Random Field model, the atlas guides the segmentation process, and characterizes which preferential location the tumor belongs to and consequently which behavior it could be associated to. Leave-one-out cross validation experiments on a large database highlight the robustness of the graph, and yield promising segmentation results.
authors.affiliation: Center for Visual Computing, Ecole Centrale Paris, Chatenay Malabry, France.|INRIA, Galen Team, Saclay-Ile-de-France Center, Chatenay Malabry, France.|Intrasense SAS, Montpellier, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Parisot
authors.affiliation: INSERM U1051, Montpellier Neurosciences Institute, University Hospital, Montpellier, France.|Department of Medical Oncology, Institut Régional du Cancer de Montpellier - Val d'Aurelle, Montpellier, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Darlix
authors.affiliation: Department of Clinical Epidemiology and Evaluation, University Hospital, Nancy, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Baumann
authors.affiliation: Department of Epidemiology, Groupe de Neuro-Oncologie du Languedoc-Roussillon, Registre des Tumeurs de l'Hérault, Institut Régional du Cancer de Montpellier - Val d'Aurelle, Montpellier, France.
authors.forename: Sonia
authors.initials: S
authors.lastname: Zouaoui
authors.affiliation: Department of Neurosurgery, HIA Val de Grâce, Paris, France.
authors.forename: Yordanka
authors.initials: Y
authors.lastname: Yordanova
authors.affiliation: Neuro-oncology Unit, Department of Neurology, University Hospital, Hôpital Central, Nancy, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Blonski
authors.affiliation: Department of Pathology, University Hospital, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Rigau
authors.affiliation: Intrasense SAS, Montpellier, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Chemouny
authors.affiliation: Neuro-oncology Unit, Department of Neurology, University Hospital, Hôpital Central, Nancy, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Taillandier
authors.affiliation: Department of Medical Oncology, Institut Régional du Cancer de Montpellier - Val d'Aurelle, Montpellier, France.|Department of Neurosurgery, University Hospital, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Bauchet
authors.affiliation: Department of Medical Oncology, Institut Régional du Cancer de Montpellier - Val d'Aurelle, Montpellier, France.|Department of Neurosurgery, University Hospital, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
authors.affiliation: Center for Visual Computing, Ecole Centrale Paris, Chatenay Malabry, France.|INRIA, Galen Team, Saclay-Ile-de-France Center, Chatenay Malabry, France.
authors.forename: Nikos
authors.initials: N
authors.lastname: Paragios
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001271:Atlases as Topic; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011336:Probability