title: Host receptors for bacteriophage adsorption.
abstract: The adsorption of bacteriophages (phages) onto host cells is, in all but a few rare cases, a sine qua non condition for the onset of the infection process. Understanding the mechanisms involved and the factors affecting it is, thus, crucial for the investigation of host-phage interactions. This review provides a survey of the phage host receptors involved in recognition and adsorption and their interactions during attachment. Comprehension of the whole infection process, starting with the adsorption step, can enable and accelerate our understanding of phage ecology and the development of phage-based technologies. To assist in this effort, we have established an open-access resource--the Phage Receptor Database (PhReD)--to serve as a repository for information on known and newly identified phage receptors.
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta, 12th Floor, Donadeo Innovation Centre for Engineering, 9211-116 Street NW, Edmonton, AB T6G 1H9, Canada.
authors.forename: Juliano
authors.initials: J
authors.lastname: Bertozzi Silva
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta, 12th Floor, Donadeo Innovation Centre for Engineering, 9211-116 Street NW, Edmonton, AB T6G 1H9, Canada.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Storms
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta, 12th Floor, Donadeo Innovation Centre for Engineering, 9211-116 Street NW, Edmonton, AB T6G 1H9, Canada dominic.sauvageau@ualberta.ca.
authors.forename: Dominic
authors.initials: D
authors.lastname: Sauvageau
mesh_terms: D000327:Adsorption; D001419:Bacteria / Q000821:virology; D001435:Bacteriophages / Q000235:genetics / Q000502:physiology*; D016208:Databases, Factual; D054884:Host-Pathogen Interactions; D006801:Humans; D011991:Receptors, Virus / Q000737:chemistry / Q000502:physiology*; D017422:Sequence Analysis, DNA
chemical_list: D011991:Receptors, Virus
keywords: bacterial phage resistance; bacteriophage adsorption; host receptors; phage attachment