title: TET2 Mutation in Adult T-Cell Leukemia/Lymphoma.
abstract: Loss-of-function of ten-eleven translocation-2 (TET2) is a common event in myeloid malignancies, and plays pleiotropic roles, including augmenting stem cell self-renewal and skewing hematopoietic cells to the myeloid lineage. TET2 mutation has also been reported in lymphoid malignancies; 5.7～12% of diffuse large B-cell lymphomas and 18～83% of angioimmunoblastic T-cell lymphomas had TET2 mutations. We investigated TET2 mutations in 22 adult T-cell leukemia/lymphoma (ATLL) patients and identified a missense mutation in 3 cases (14%). TET2 mutation occurred in a number of ATLL patients and was likely involved in their leukemogenesis.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shimoda
authors.forename: Kotaro
authors.initials: K
authors.lastname: Shide
authors.forename: Takuro
authors.initials: T
authors.lastname: Kameda
authors.forename: Tomonori
authors.initials: T
authors.lastname: Hidaka
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kubuki
authors.forename: Ayako
authors.initials: A
authors.lastname: Kamiunten
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sekine
authors.forename: Keiichi
authors.initials: K
authors.lastname: Akizuki
authors.forename: Haruko
authors.initials: H
authors.lastname: Shimoda
authors.forename: Takumi
authors.initials: T
authors.lastname: Yamaji
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hiroo
authors.initials: H
authors.lastname: Abe
authors.forename: Tadashi
authors.initials: T
authors.lastname: Miike
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Iwakiri
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tahara
authors.forename: Mitsue
authors.initials: M
authors.lastname: Sueta
authors.forename: Shojiro
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Satoru
authors.initials: S
authors.lastname: Hasuike
authors.forename: Kenji
authors.initials: K
authors.lastname: Nagata
authors.forename: Akira
authors.initials: A
authors.lastname: Kitanaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D049308:Dioxygenases; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D049308:Dioxygenases; C541081:TET2 protein, human