title: Recent advances in polymeric micelles for anti-cancer drug delivery.
abstract: Block co-polymeric micelles receive increased attention due to their ability to load therapeutics, deliver the cargo to the site of action, improve the pharmacokinetic of the loaded drug and reduce off-target cytotoxicity. While polymeric micelles can be developed with improved drug loading capabilities by modulating hydrophobicity and hydrophilicity of the micelle forming block co-polymers, they can also be successfully cancer targeted by surface modifying with tumor-homing ligands. However, maintenance of the integrity of the self-assembled system in the circulation and disassembly for drug release at the site of drug action remain a challenge. Therefore, stimuli-responsive polymeric micelles for on demand drug delivery with minimal off-target effect has been developed and extensively investigated to assess their sensitivity. This review focuses on discussing various polymeric micelles currently utilized for the delivery of chemotherapeutic drugs. Designs of various stimuli-sensitive micelles that are able to control drug release in response to specific stimuli, either endogenous or exogenous have been delineated.
authors.affiliation: Birla Institute of Technology and Science-Pilani, Hyderabad, Jawahar Nagar, Shameerpet, Hyderabad 500078, Telangana, India.
authors.forename: Swati
authors.initials: S
authors.lastname: Biswas
authors.affiliation: Birla Institute of Technology and Science-Pilani, Hyderabad, Jawahar Nagar, Shameerpet, Hyderabad 500078, Telangana, India.
authors.forename: Preeti
authors.initials: P
authors.lastname: Kumari
authors.affiliation: Birla Institute of Technology and Science-Pilani, Hyderabad, Jawahar Nagar, Shameerpet, Hyderabad 500078, Telangana, India.
authors.forename: Prit Manish
authors.initials: PM
authors.lastname: Lakhani
authors.affiliation: Birla Institute of Technology and Science-Pilani, Hyderabad, Jawahar Nagar, Shameerpet, Hyderabad 500078, Telangana, India. Electronic address: balaram@hyderabad.bits-pilani.ac.in.
authors.forename: Balaram
authors.initials: B
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy; D011108:Polymers / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D011108:Polymers
keywords: Anticancer; Block polymer; Cancer therapy; EPR effect; Polymeric micelles; Targeted delivery