title: Automated radiosynthesis of [(11)C]L-deprenyl-D2 and [(11)C]D-deprenyl using a commercial platform.
abstract: Two (11)C-labelled PET tracers, (R)-N-[(11)C]methyl-N-(3,3-dideuteropropargyl)-1-phenylpropan-2-amine ([(11)C]L-deprenyl-D2, [(11)C]DED) and (S)-N-[(11)C]methyl-N-propargyl-1-phenylpropan-2-amine ([(11)C]D-deprenyl, [(11)C]DDE) were synthesised. One step N-alkylation with [(11)C]MeI or [(11)C]MeOTf was performed using the automated platform TRACERlab® FX-C Pro. The labelled products were obtained with (37±15)% (n=10) (end of synthesis, decay corrected from [(11)C]MeI) radiochemical yields from [(11)C]MeI after 38±3min synthesis time. In all cases, radiochemical purity was over 99% when [(11)C]MeOTf was used. This synthesis using a commercial platform makes these tracers more accessible for clinical research purposes.
authors.affiliation: Centro Uruguayo de Imagenología Molecular (CUDIM), Ricaldoni 2010, Montevideo 11600, Uruguay.
authors.forename: Pablo
authors.initials: P
authors.lastname: Buccino
authors.affiliation: Centro Uruguayo de Imagenología Molecular (CUDIM), Ricaldoni 2010, Montevideo 11600, Uruguay.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Kreimerman
authors.affiliation: Centro Uruguayo de Imagenología Molecular (CUDIM), Ricaldoni 2010, Montevideo 11600, Uruguay.
authors.forename: Kevin
authors.initials: K
authors.lastname: Zirbesegger
authors.affiliation: Centro Uruguayo de Imagenología Molecular (CUDIM), Ricaldoni 2010, Montevideo 11600, Uruguay; Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Gral. Flores 2124, Montevideo 11800, Uruguay.
authors.forename: Williams
authors.initials: W
authors.lastname: Porcal
authors.affiliation: Centro Uruguayo de Imagenología Molecular (CUDIM), Ricaldoni 2010, Montevideo 11600, Uruguay; Cátedra de Radioquímica, Facultad de Química, Universidad de la República, Gral. Flores 2124, Montevideo 11800, Uruguay. Electronic address: eduardo.savio@cudim.org.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Savio
authors.affiliation: Centro Uruguayo de Imagenología Molecular (CUDIM), Ricaldoni 2010, Montevideo 11600, Uruguay.
authors.forename: Henry
authors.initials: H
authors.lastname: Engler
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry; D006801:Humans; D007553:Isotope Labeling / Q000295:instrumentation / Q000379:methods; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D012642:Selegiline / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002250:Carbon Radioisotopes; D008996:Monoamine Oxidase Inhibitors; D019275:Radiopharmaceuticals; D012642:Selegiline
keywords: Automated synthesis; PET chemistry; [(11)C]D-deprenyl; [(11)C]L-deprenyl-D(2)