title: Dietary burden calculations relating to fish metabolism studies.
abstract: Fish farming is increasingly dependent on plant commodities as a source of feed leading to an increased risk for pesticide residues in aquaculture diets and consequently their transfer into aquaculture food products. The European pesticide regulation requires fish metabolism and fish feeding studies where residues in fish feed exceed 0.1 mg kg(-1) of the total diet (dry weight basis) to enable the setting of appropriate maximum residue levels in fish commodities. Fish dietary burden calculation is therefore an important prerequisite to decide on further experimental testing as part of the consumer risk assessment. In this review, the different aquaculture production systems are compared with regard to their specific feeding practices and the principles of dietary burden calculation are described.
authors.affiliation: Department Bioaccumulation and Animal Metabolism, Fraunhofer IME, 57392 Schmallenberg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Schlechtriem
authors.affiliation: Department of Experimental Toxicology and ZEBET, Unit Animal Husbandry, Aquaculture and Reference Materials, Federal Institute for Risk Assessment, 10589 Berlin, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Pucher
authors.affiliation: Department of Pesticides Safety, Unit Residues and Analytical Methods, Federal Institute for Risk Assessment, 10589 Berlin, Germany.
authors.forename: Britta
authors.initials: B
authors.lastname: Michalski
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D017756:Aquaculture; D003257:Consumer Product Safety; D004032:Diet / Q000662:veterinary*; D005395:Fish Oils / Q000737:chemistry; D005396:Fish Products / Q000032:analysis; D005399:Fishes / Q000378:metabolism*; D005506:Food Contamination / Q000032:analysis; D010573:Pesticide Residues / Q000032:analysis*
chemical_list: D005395:Fish Oils; D010573:Pesticide Residues
keywords: aquaculture; dietary exposure; feed residues; fish feeding; pesticide regulation; risk assessment