title: Rs5498 polymorphism may be a risk factor for coronary heart disease in Chinese population: evidence from a meta-analysis involving 5537 subjects.
abstract: Despite large numbers of studies from Chinese population related to the association between rs5498 polymorphism and coronary heart disease (CHD) risk, the results are inconsistent probably due to the difference in the nationalities. To further evaluate the impact of the rs5498 polymorphism on CHD risk of different nationalities population, we performed this meta-analysis. We comprehensively searched the eligible studies for the present meta-analysis through China National Knowledge Infrastructure (CNKI), PubMed, EMBASE databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were obtained to evaluate the strength of the association between rs5498 polymorphism and CHD risk. Finally, a total of 18 studies including 5537 subjects met the inclusion criteria. The pooled result showed that the rs5498 polymorphism was significantly associated with an increased risk of CHD in allele comparison model (OR=1.43, 95% CI=1.17-1.73, P=0.000), homozygote model (OR=1.23, 95% CI=1.03-1.46, P=0.000), heterozygote model (OR=1.23, 95% CI=1.03-1.46, P=0.018), dominant model (OR=1.45, 95% CI=1.21-1.74, P=0.001) and recessive model (OR=2.17, 95% CI=1.70-2.77, P=0.002). But subgroup analysis only supported the results from data of Han and Zhuang population in South China and North China. We did not find any evidences revealing some relationship between them in the Uygur population of Northwest China. Totally, the results of our meta-analysis indicate that the rs5498 polymorphism may be associated with coronary heart disease in Han and Zhuang population but not in Uyghur population. A large number of well-designed and multiracial studies should be conducted to re-evaluate the relationship.
authors.affiliation: Department of Cardiology, Yantai Yeda Hospital Affiliated to Binzhou Medical University Yantai 264006, Shandong, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cui
authors.affiliation: Department of Cardiology, Yantai Yeda Hospital Affiliated to Binzhou Medical University Yantai 264006, Shandong, China.
authors.forename: Shicong
authors.initials: S
authors.lastname: Jing
authors.affiliation: Department of Geriatrics, Yantai Yeda Hospital Affiliated to Binzhou Medical University Yantai 264006, Shandong, China.
authors.forename: Xiangfen
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zong
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital to Binzhou Medical University Bibzhou 256603, Shandong, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Yantai Yeda Hospital Affiliated to Binzhou Medical University Yantai 264006, Shandong, China.
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Jiao
authors.affiliation: Department of Radiology, Yantai Yeda Hospital Affiliated to Binzhou Medical University Yantai 264006, Shandong, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Peng
authors.affiliation: Department of Radiology, Yantai Yeda Hospital Affiliated to Binzhou Medical University Yantai 264006, Shandong, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Yantai Yeda Hospital Affiliated to Binzhou Medical University Yantai 264006, Shandong, China.
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Radiology, Yantai Haigang Hospital Yantai 264002, Shandong, China.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Niu
keywords: Coronary heart disease; meta-analysis; polymorphism; rs5498