title: Inhibition of serotonin reuptake in the prepubertal rat ovary by fluoxetine and effects on ovarian functions.
abstract: Fluoxetine (FLX), a selective serotonin reuptake inhibitor is an antidepressant in the treatment of mood disorders. Its impact on reproductive processes is incompletely known. The present study analyzed the reproductive effects of FLX in prepubertal female rats. Two experiments were conducted. First (acute administration), 30-day-old female rats were injected intraperitoneally with 5mg/kg of fluoxetine-hydrochloride, and were terminated 24, 48 or 72h after the treatment. Second (subchronic administration), FLX was injected on days 30-33 of age, and the animals were terminated the day of first estrus. In acute treatment estradiol concentration increased to 72h. In subchronic treatment increased serotonin concentration in ovaries and decreased the number of ova shed. An increase in number of atretic follicles and oocyte fragmentation was observed in these animals. The results suggest that FLX acts on the ovary or hypothalamus-pituitary axis resulting in modifications of the follicular development and ovulation.
authors.affiliation: Unidad de Investigación en Biología de la Reproducción, Laboratorio de Pubertad, Facultad de Estudios Superiores Zaragoza, UNAM, Iztapalapa, CP 09230 México D.F., Mexico.
authors.forename: Jessica
authors.initials: J
authors.lastname: Romero-Reyes
authors.affiliation: Laboratorio de Hormonas Proteicas, Instituto Nacional de Ciencias Médicas y de Nutrición Salvador Zubirán, Tlalpan, CP 14080 México D.F., Mexico.
authors.forename: Mario
authors.initials: M
authors.lastname: Cárdenas
authors.affiliation: Departamento de Biología de la Reproducción, UAM Iztapalapa, CP 09340 México D.F., Mexico.
authors.forename: Pablo
authors.initials: P
authors.lastname: Damián-Matsumura
authors.affiliation: Unidad de Investigación en Biología de la Reproducción, Laboratorio de Pubertad, Facultad de Estudios Superiores Zaragoza, UNAM, Iztapalapa, CP 09230 México D.F., Mexico.
authors.forename: Roberto
authors.initials: R
authors.lastname: Domínguez
authors.affiliation: Unidad de Investigación en Biología de la Reproducción, Laboratorio de Pubertad, Facultad de Estudios Superiores Zaragoza, UNAM, Iztapalapa, CP 09230 México D.F., Mexico. Electronic address: marayalamx@yahoo.com.mx.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Ayala
mesh_terms: D000367:Age Factors; D000818:Animals; D005260:Female; D005473:Fluoxetine / Q000633:toxicity*; D012739:Gonadal Steroid Hormones / Q000097:blood; D006824:Hybridization, Genetic; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism; D009865:Oocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006080:Ovarian Follicle / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D010060:Ovulation / Q000187:drug effects*; D020318:Rats, Long-Evans; D017208:Rats, Wistar; D044346:Receptor, Serotonin, 5-HT1D / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000633:toxicity*; D012741:Sexual Maturation; D013997:Time Factors
chemical_list: D005473:Fluoxetine; D012739:Gonadal Steroid Hormones; D044346:Receptor, Serotonin, 5-HT1D; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Fluoxetine; Follicle development; Oocyte; Ovary; Rat; Serotonin