title: Twin pregnancy after intracytoplasmic sperm injection in woman aged 49 using autologous oocytes by mild ovarian stimulation: a case report.
abstract: There were few reports about infertile women aged 45 and above undergoing IVF/ICSI. We are reporting the case of an aged 49 woman who delivered the twins after ICSI using autologous oocytes by mild ovarian stimulation. The patient presented with 26-year primary infertility caused by double fallopian tubes obstruction and man oligoasthenozoospermia. We gave her the treatment with mild ovarian stimulation cycle of clomiphene citrate (CC) and follicle stimulating hormone (FSH) undergoing ICSI, and transferred two fertilization-blastocysts. The outcome measured was the live birth. The twins were delivered by cesarean section operation at 37 pregnancy weeks for the moderate pregnancy-induced hypertension. In summary, we found it is feasible for women with advanced age to undergo ART while the accompanied risk of pregnancy complications and other issues need to be further evaluated.
authors.affiliation: Reproductive Medical Center, Shanghai Tongji Hospital Affiliated to Tongji University Shanghai, China.
authors.forename: Guimin
authors.initials: G
authors.lastname: Yan
authors.affiliation: Reproductive Medical Center, Shanghai Tongji Hospital Affiliated to Tongji University Shanghai, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Xie
authors.affiliation: Reproductive Medical Center, Shanghai Tongji Hospital Affiliated to Tongji University Shanghai, China.
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Reproductive Medical Center, Shanghai Tongji Hospital Affiliated to Tongji University Shanghai, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Shi
authors.affiliation: Reproductive Medical Center, Shanghai Tongji Hospital Affiliated to Tongji University Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Reproductive Medical Center, Shanghai Tongji Hospital Affiliated to Tongji University Shanghai, China.
authors.forename: Yingling
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Reproductive Medical Center, Shanghai Tongji Hospital Affiliated to Tongji University Shanghai, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Tong
authors.affiliation: Reproductive Medical Center, Shanghai Tongji Hospital Affiliated to Tongji University Shanghai, China.
authors.forename: Yazhong
authors.initials: Y
authors.lastname: Ji
keywords: Advanced age; autologous oocytes; endometrial receptivity; mild ovarian stimulation