title: Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation.
abstract: Circadian rhythms have long been known to regulate numerous physiological processes that vary across the diurnal cycle. The circadian clock system also controls various parameters of the immune system and its biological defense functions, allowing an organism to anticipate daily changes in activity and feeding and the associated risk of infection. Inflammation is an immune response triggered in living organisms in response to external stimuli. The risk of sepsis, an excessive inflammatory response, has been shown to have a diurnal variation. On the other hand, inflammatory responses are emerging to be induced by endogenous factors. Recent studies have suggested that chronic inflammation causes chronic diseases including rheumatoid arthritis, allergies, and aging-related diseases and that proteins encoded by clock genes affect the development of such chronic inflammatory diseases or increase the severity of their symptoms. Therefore, detailed understanding of circadian rhythm effects on inflammatory responses is expected to lead to new strategies for prevention or treatment of inflammatory diseases.
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Kizaki
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, 5323, Harry Hines Boulevard, Dallas, TX 75390 USA.
authors.forename: Shogo
authors.initials: S
authors.lastname: Sato
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Shirato
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Sakurai
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Junetsu
authors.initials: J
authors.lastname: Ogasawara
authors.affiliation: Faculty & Graduate School of Health & Sports Science, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Izawa
authors.affiliation: Faculty & Graduate School of Health & Sports Science, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ohira
authors.affiliation: Department of Pharmaceutical Sciences, Ritsumeikan University, College of Pharmaceutical Sciences, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohno
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology*; D007107:Immune System; D007109:Immunity; D007249:Inflammation / Q000276:immunology*