title: Canonical and non-canonical Wnt signaling control the regeneration of amputated rodent vibrissae follicles.
abstract: Although mammals are notoriously poor at regeneration compared with many lower-order species, the hair follicle, particular to mammals, is capable of regeneration following partial amputation. The detailed internal mechanism of this phenomenon is still unclear. Development and regrowth of the hair follicle depends on dermal-epidermal interaction within the hair follicle. Previous studies have shown that Wnt/β-catenin, Shh, Bmp, PDGF, TGF and Notch signals all take part in the development and growth of the hair follicle, and the Wnt/β-catenin signaling additionally plays an indispensable role in hair follicle morphogenesis and regrowth. In this study, we investigated the localization, as well as, protein levels of Wnt/β-catenin signaling molecules during amputated whisker follicle regeneration.
authors.affiliation: Department of Histology and Embryology, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong Province, People's Republic of China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Yuan
authors.affiliation: Department of Histology and Embryology, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong Province, People's Republic of China.
authors.forename: Keng
authors.initials: K
authors.lastname: Huang
authors.affiliation: Department of Cell Biology, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong Province, People's Republic of China.
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Xu
authors.affiliation: Department of Histology and Embryology, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong Province, People's Republic of China.
authors.forename: Xian-Cai
authors.initials: XC
authors.lastname: Chen
authors.affiliation: Emergency Department, The Second Affiliated Hospital, Shantou University Medical College, North Dongxia Road, Shantou, 515041, Guangdong Province, People's Republic of China.
authors.forename: Hai-Hong
authors.initials: HH
authors.lastname: Li
authors.affiliation: Department of Cell Biology, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong Province, People's Republic of China.
authors.forename: Bo-Zhi
authors.initials: BZ
authors.lastname: Cai
authors.affiliation: Department of Histology and Embryology, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong Province, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Histology and Embryology, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong Province, People's Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Tissue Engineering Laboratory, First Affiliated Hospital, Shantou University Medical College, No. 57 Changping Road, Shantou, 515041, Guangdong Province, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Histology and Embryology, Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong Province, People's Republic of China. cocolin@126.com.
authors.forename: Chang-Min
authors.initials: CM
authors.lastname: Lin
mesh_terms: D000818:Animals; D055395:Bone Morphogenetic Protein 1 / Q000235:genetics / Q000378:metabolism; D052004:Bone Morphogenetic Protein Receptors / Q000235:genetics / Q000378:metabolism; D020405:Dermis / Q000378:metabolism / Q000637:transplantation*; D004210:Dissection; D005260:Female; D005786:Gene Expression Regulation; D018859:Hair Follicle / Q000378:metabolism / Q000637:transplantation*; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism; D012038:Regeneration / Q000235:genetics*; D014738:Vibrissae / Q000378:metabolism / Q000637:transplantation*; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000235:genetics*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins; D010982:Platelet-Derived Growth Factor; D051880:Receptors, Notch; C546888:Shh protein, rat; D051153:Wnt Proteins; D051176:beta Catenin; D052004:Bone Morphogenetic Protein Receptors; C525707:Bmp1 protein, mouse; D055395:Bone Morphogenetic Protein 1
keywords: Differentiation; Hair follicle; Immunofluorescence staining; Regeneration; Stem cell; Wnt/β-catenin signaling