title: Historical Hallmarks of Anticoagulation and Antiplatelet Agents.
abstract: Thrombosis is a well known phenomenon among physicians since antiquity. A variety of peculiar agents, such as leeches and bark, were used to prevent it. Hirudin was used during the 19th century. The next eon, heparin, strepokinase, urokinase, TPA, dicumarol, warfarin, aspirin, ticlopidine, Clopidogrel, SSHA and SP54 provoked huge advances in anticoagulation. During 21st century with the use of fondaparinux, dabigatran, rivaroxaban and Ticagrelor antithrombotic prevention and therapeutic interaction entered an era of medical challenges. Although the risk after a thrombotic episode is now highly reduced, blood clots still present damaging or even lethal consequences in human organisms and further research is strongly recommended.
authors.affiliation: Ierolohiton 155, Agioi Anargyroi, Volos, Greece, P.C. 38334. gregorytsoucalas@yahoo.gr.
authors.forename: Gregory
authors.initials: G
authors.lastname: Tsoucalas
authors.forename: Jacques
authors.initials: J
authors.lastname: Chevallier
authors.forename: Marianna
authors.initials: M
authors.lastname: Karamanou
authors.forename: Theodoros
authors.initials: T
authors.lastname: Papaioannou
authors.forename: Markos
authors.initials: M
authors.lastname: Sgantzos
authors.forename: George
authors.initials: G
authors.lastname: Androutsos
mesh_terms: D000925:Anticoagulants / Q000266:history* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000266:history* / Q000494:pharmacology; D013927:Thrombosis / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors