title: Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen.
abstract: Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen. Furthermore, PPD exacerbated thrombus formation in rats in comparison with those untreated. Our results suggest that PPD is an important platelet primer predisposing platelets to promote thrombus formation in response to vascular injury. This should prompt the authorities to consider controlling the marketing of this product.
authors.affiliation: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Canada.
authors.forename: Younes
authors.initials: Y
authors.lastname: Zaid
authors.forename: Fatimazahra
authors.initials: F
authors.lastname: Marhoume
authors.forename: Nezha
authors.initials: N
authors.lastname: Senhaji
authors.forename: Kevin
authors.initials: K
authors.lastname: Kojok
authors.forename: Hicham
authors.initials: H
authors.lastname: Boufous
authors.forename: Abdallah
authors.initials: A
authors.lastname: Naya
authors.forename: Mounia
authors.initials: M
authors.lastname: Oudghiri
authors.forename: Youssef
authors.initials: Y
authors.lastname: Darif
authors.forename: Norddine
authors.initials: N
authors.lastname: Habti
authors.forename: Soukaina
authors.initials: S
authors.lastname: Zouine
authors.forename: Fekhaoui
authors.initials: F
authors.lastname: Mohamed
authors.forename: Abderahmane
authors.initials: A
authors.lastname: Chait
authors.forename: Abdellah
authors.initials: A
authors.lastname: Bagri
mesh_terms: D000818:Animals; D003094:Collagen / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010655:Phenylenediamines / Q000633:toxicity*; D015539:Platelet Activation / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D017207:Rats, Sprague-Dawley; D013927:Thrombosis / Q000209:etiology*
chemical_list: D010655:Phenylenediamines; D003094:Collagen; C029728:4-phenylenediamine