title: [Quality of biomaterials in liquid- and tissue-biobanking].
abstract: During the last years, many biobanks that collect and provide biomaterials as well as associated phenotypical data have been established on national and international levels. However, due to the heterogeneity in structure and process landscape between biobanks, quality issues arise, which might affect equivalence of sample quality and thus usability of biomaterials for scientific research projects as well as interoperability of biobanks.Here, we will give an overview on the influence of biobanking procedures on sample quality and on potential quality control measures for research biobanks, mainly focusing on tissue and liquid biomaterials. General infrastructural requirements as well as the influence of preanalytical variables affecting sample quality and usability are described and opportunities and drawbacks of different quality assurance procedures are discussed. As there is increasing consensus on national and international levels that evidence-based standardization and harmonization of biobank structures and workflows are urgently needed for quality-assured biobanking, recent activities in the development and implementation of an ISO Standard for biobanks will be illustrated in the last section of this article.
authors.affiliation: Pathologisches Institut, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.|Gewebebank des Nationalen Centrums für Tumorerkrankungen (NCT), Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
authors.forename: Esther
authors.initials: E
authors.lastname: Herpel
authors.affiliation: Gewebebank des Nationalen Centrums für Tumorerkrankungen (NCT), Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Schmitt
authors.affiliation: Institut für Klinische Chemie und Laboratoriumsdiagnostik, Universitätsklinikum Jena, Jena, Deutschland. Michael.Kiehntopf@med.uni-jena.de.|Integrierte Biobank Jena (IBBJ), Universitätsklinikum Jena, Jena, Deutschland. Michael.Kiehntopf@med.uni-jena.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Kiehntopf
mesh_terms: D018070:Biological Specimen Banks / Q000592:standards*; D035843:Biomedical Research / Q000592:standards*; D005858:Germany; D006801:Humans; D038622:Internationality; D017410:Practice Guidelines as Topic; D011785:Quality Assurance, Health Care / Q000592:standards*; D011786:Quality Control; D013048:Specimen Handling / Q000592:standards*; D009927:Tissue and Organ Procurement / Q000592:standards*
keywords: Biomaterial; Liquid biobanking; Preanalytics; Quality markers; Tissue biobanking