title: Strength in Diversity: Hidden Genetic Depths of Mycobacterium tuberculosis.
abstract: Next-generation whole genome sequencing data is currently being utilised to explore Mycobacterium tuberculosis genetic diversity. Studies have focused in particular on the evolution of drug resistance, and have revealed a surprising degree of dynamic population heterogeneity, with implications for transmission studies, treatment regimens and new drug target development.
authors.affiliation: DST-NRF Centre of Excellence for Biomedical Tuberculosis Research/SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. Electronic address: ssampson@sun.ac.za.
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Sampson
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology; D014644:Genetic Variation; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D014376:Tuberculosis / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents