title: The lymphatic system and pancreatic cancer.
abstract: This review summarizes current knowledge of the biology, pathology and clinical understanding of lymphatic invasion and metastasis in pancreatic cancer. We discuss the clinical and biological consequences of lymphatic invasion and metastasis, including paraneoplastic effects on immune responses and consider the possible benefit of therapies to treat tumors that are localized to lymphatics. A review of current techniques and methods to study interactions between tumors and lymphatics is presented.
authors.affiliation: Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198-5950, USA.
authors.forename: Darci M
authors.initials: DM
authors.lastname: Fink
authors.affiliation: Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198-5950, USA.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Steele
authors.affiliation: Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198-5950, USA. Electronic address: mahollin@unmc.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Hollingsworth
mesh_terms: D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000276:immunology / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D002450:Cell Communication; D006801:Humans; D008197:Lymph Node Excision; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis; D008208:Lymphatic System / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009361:Neoplasm Invasiveness; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D059016:Tumor Microenvironment
keywords: Lymph node; Lymphatics; Pancreatic cancer