title: Irreversible Electroporation (IRE) in Renal Tumors.
abstract: Small renal masses (SRMs) have been traditionally managed with surgical resection. Minimally invasive nephron-sparing treatment methods are preferred to avoid harmful consequences of renal insufficiency, with partial nephrectomy (PN) considered the gold standard. With increase in the incidence of the SRMs and evolution of ablative technologies, percutaneous ablation is now considered a viable treatment alternative to surgical resection with comparable oncologic outcomes and better nephron-sparing property. Traditional thermal ablative techniques suffer from unique set of challenges in treating tumors near vessels or critical structures. Irreversible electroporation (IRE), with its non-thermal nature and connective tissue-sparing properties, has shown utility where traditional ablative techniques face challenges. This review presents the role of IRE in renal tumors based on the most relevant published literature on the IRE technology, animal studies, and human experience.
authors.affiliation: Department of Radiology, Division of Vascular Interventional Radiology, University of Miami Miller School of Medicine, 1475 NW 12th Avenue Grd Fl. C-085, 33136, Miami, FL, USA. gnarayanan@med.miami.edu.
authors.forename: Govindarajan
authors.initials: G
authors.lastname: Narayanan
authors.affiliation: Department of Radiology, Division of Vascular Interventional Radiology, University of Miami Miller School of Medicine, 1475 NW 12th Avenue Grd Fl. C-080, 33136, Miami, FL, USA. mdoshi@med.miami.edu.
authors.forename: Mehul H
authors.initials: MH
authors.lastname: Doshi
mesh_terms: D000818:Animals; D018274:Electroporation; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy*; D009392:Nephrectomy / Q000379:methods
keywords: IRE; Irreversible electroporation; Kidney cancer; Renal ablation; Renal cell carcinoma; Renal mass