title: Neurotensin: A role in substance use disorder?
abstract: Neurotensin is a tridecapeptide originally identified in extracts of bovine hypothalamus. This peptide has a close anatomical and functional relationship with the mesocorticolimbic and nigrostriatal dopamine system. Neural circuits containing neurotensin were originally proposed to play a role in the mechanism of action of antipsychotic agents. Additionally, neurotensin-containing pathways were demonstrated to mediate some of the rewarding and/or sensitizing properties of drugs of abuse.This review attempts to contribute to the understanding of the role of neurotensin and its receptors in drug abuse. In particular, we will summarize the potential relevance of neurotensin, its related compounds and neurotensin receptors in substance use disorders, with a focus on the preclinical research.
authors.affiliation: Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy frl@unife.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Ferraro
authors.affiliation: Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Tiozzo Fasiolo
authors.affiliation: Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
authors.forename: Sarah
authors.initials: S
authors.lastname: Beggiato
authors.affiliation: Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
authors.forename: Andrea C
authors.initials: AC
authors.lastname: Borelli
authors.affiliation: Department of Toxicology, Medical College, Jagiellonian University, Kraków, Poland.
authors.forename: Lucyna
authors.initials: L
authors.lastname: Pomierny-Chamiolo
authors.affiliation: Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Frankowska
authors.affiliation: Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Antonelli
authors.affiliation: Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Tomasini
authors.affiliation: Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
authors.forename: Kjell
authors.initials: K
authors.lastname: Fuxe
authors.affiliation: Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Filip
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D009496:Neurotensin / Q000378:metabolism*; D018028:Receptors, Neurotensin / Q000378:metabolism*; D012201:Reward; D019966:Substance-Related Disorders / Q000503:physiopathology*
chemical_list: D014150:Antipsychotic Agents; D018028:Receptors, Neurotensin; D009496:Neurotensin; D004298:Dopamine
keywords: Agonist; antagonist; behavioral sensitization; conditioned place preference; drug abuse; drug self-administration; hyperlocomotion; neurotensin; neurotensin receptor; preclinical research; review