title: [Ebola virus disease: Update].
abstract: The first known Ebola outbreak occurred in 1976. Since then, 24 limited outbreaks had been reported in Central Africa, but never affecting more than 425 persons. The current outbreak in Western Africa is the largest in history with 28,220 reported cases and 11,291 deaths. The magnitude of the epidemic has caused worldwide alarm. For the first time, evacuated patients were treated outside Africa, and secondary cases have occurred in Spain and the United States. Since the start of the current epidemic, our knowledge about the epidemiology, clinical picture, laboratory findings, and virology of Ebola virus disease has considerably expanded. For the first time, experimental treatment has been tried, and there have been spectacular advances in vaccine development. A review is presented of these advances in the knowledge of Ebola virus disease.
authors.affiliation: Unidad de Medicina Tropical y del Viajero, Servicio de Medicina Interna, Hospital La Paz-Cantoblanco-Carlos III, IdiPAZ, Madrid, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: de la Calle-Prieto
authors.affiliation: Unidad de Medicina Tropical y del Viajero, Servicio de Medicina Interna, Hospital La Paz-Cantoblanco-Carlos III, IdiPAZ, Madrid, España.
authors.forename: Marta
authors.initials: M
authors.lastname: Arsuaga-Vicente
authors.affiliation: Unidad de Enfermedades Infecciosas y Microbiología Clínica, Servicio de Medicina Interna, Hospital La Paz-Cantoblanco-Carlos III, IdiPAZ, Madrid, España.
authors.forename: Marta
authors.initials: M
authors.lastname: Mora-Rillo
authors.affiliation: Servicio de Medicina Interna, Hospital La Paz-Cantoblanco-Carlos III, IdiPAZ, Madrid, España.
authors.forename: Francisco
authors.initials: F
authors.lastname: Arnalich-Fernandez
authors.affiliation: Unidad de Enfermedades Infecciosas y Microbiología Clínica, Servicio de Medicina Interna, Hospital La Paz-Cantoblanco-Carlos III, IdiPAZ, Madrid, España. Electronic address: joser.arribas@salud.madrid.org.
authors.forename: Jose Ramon
authors.initials: JR
authors.lastname: Arribas
mesh_terms: D000349:Africa / Q000453:epidemiology; D000354:Africa, Western / Q000453:epidemiology; D004196:Disease Outbreaks; D029043:Ebolavirus; D014943:Global Health; D019142:Hemorrhagic Fever, Ebola / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D013030:Spain / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
keywords: Ebola; Epidemia; Epidemic; Tratamiento; Treatment; Vaccine; Vacuna