title: Serum 25-hydroxyvitamin D3 levels in children with allergic or nonallergic rhinitis.
abstract: OBJECTIVE
  The relationship between vitamin D and allergic diseases such as asthma and atopic dermatitis is shown in several studies. But there is a lack of knowledge about vitamin D status in children with allergic rhinitis (AR). We aimed to investigate serum vitamin D levels of children with AR or nonallergic rhinitis (NAR), to compare with normal subjects and to evaluate the relationship between vitamin D and the severity of AR.
  
  
  METHODS
  The study included a total of 141 children (76 patients with rhinitis and 65 control subjects), who applied to the Pediatric allergy immunology outpatient. Skin prick tests were performed using the same antigens for all patients. Serum 25-hydroxyvitamin D3 (25OHD3) levels were measured. AR was classified according to the ARIA guidelines.
  
  
  RESULTS
  Mean 25OHD3 levels were 18.07±6.1ng/mL in the AR group, 14.81±4.86 in the NAR, and 24.03±9.43ng/mL in the control group. These differences among groups were statistically significant (p=0.001). Vitamin D status was determined as deficient in 32 (66.7%) patients, insufficient in 14 (29.2%) and normal in 2 (4.2%) of the AR group. These frequencies for NAR and control groups are 25 (89.3%), 3 (10.7%), 0, and 25 (38.5%), 32 (49.2%), 8 (12.3%), respectively. Vitamin D status was found to be different among groups (p=0.001). There were not any association between 25OHD3 levels and allergen sensitivity (p>0.05). The comparison of the mean 25OHD3 levels according to the severity and duration of AR did not detect statistically significant difference among groups (respectively, p=0.384, p=0.23 Denburg J, Fokkens WJ, Togias A5).
  
  
  CONCLUSIONS
  The mean serum 25OHD3 levels of the children both with AR and NAR were lower than control group. No association between 25OHD3 levels and allergen sensitivities was found in our study. We did not find any relationship between 25OHD3 levels and the severity and duration of allergic rhinitis.
authors.affiliation: Zeynep Kamil Woman and Children's Diseases Training and Research Hospital, Department of Pediatric Allergy-Immunology, Istanbul, Turkey. Electronic address: mdmahmut@yahoo.com.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Dogru
authors.affiliation: Erzurum District Training and Research Hospital, Department of Pediatric Allergy-Immunology, Erzurum, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Suleyman
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology*; D002112:Calcifediol / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D012220:Rhinitis / Q000097:blood / Q000276:immunology; D065631:Rhinitis, Allergic / Q000097:blood* / Q000276:immunology; D012720:Severity of Illness Index; D012882:Skin Tests; D014808:Vitamin D Deficiency / Q000097:blood* / Q000276:immunology
chemical_list: D000485:Allergens; D002112:Calcifediol
keywords: Allergic rhinitis; Child; Sensitivity; Severity; Vitamin D