title: Efficacy of silodosin in the treatment of distal ureteral stones 4 to 10 mm in diameter.
abstract: OBJECTIVE
  Few studies have investigated the efficacy of silodosin, a recently introduced selective alpha 1-A adrenoceptor antagonist, in medical expulsive therapy (MET) for ureteral calculi. The results of these studies, which all evaluated the efficacy of 8 mg/day, indicate that silodosin is a potential treatment for ureteral calculi. This study investigated the efficacy of 4 mg/day of silodosin for MET of distal ureteral stones 4 to 10 mm in diameter.
  
  
  METHODS
  After 70 patients had been randomized into 2 groups of 35 patients each, both the control and experimental groups (groups 1 and 2, respectively) were advised to take 75 mg/day of diclofenacsodiumas needed for pain relief but only the experimental group to take 4 mg/day of silodosin. After 21 days, the groups were compared regarding the stone expulsion rate and duration, number of renalcolicepisodes, and analgesicdosage.
  
  
  RESULTS
  The median expulsion rates were 71.4% and 91.4% in groups 1 and 2, respectively, and the difference between them was significant (P=0.031). The median expulsion durations were 12.91±6.14 and 8.03±4.99 days, respectively, and the difference between them was significant (P<0.001). No significant differences were found regarding the median number of renal colic episodes or median analgesic dosage. While no patients in group 1 experienced side effects, 5 patients (14%) in group 2 experienced retrograde ejaculation.
  
  
  CONCLUSIONS
  These results indicate that 4 mg/day of silodos in facilitates the expulsion of distal ureteral stones 4 to 10 mm in diameter but does not significantly reduce the number of renal colic episodes or analgesic dosage.
authors.affiliation: Department of Urology, Antalya Training and Research Hospital Antalya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yuksel
authors.affiliation: Department of Urology, Konya Training and Research Hospital Konya, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: Department of Urology, Antalya Training and Research Hospital Antalya, Turkey.
authors.forename: Husnu
authors.initials: H
authors.lastname: Tokgoz
authors.affiliation: Department of Urology, Antalya Training and Research Hospital Antalya, Turkey.
authors.forename: Soner
authors.initials: S
authors.lastname: Yalcinkaya
authors.affiliation: Department of Urology, Babaeski State Hospital Antalya, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Baş
authors.affiliation: Department of Urology, Baskent University Medical Faculty, Alanya Practice and Research Center Antalya, Turkey.
authors.forename: Tümay
authors.initials: T
authors.lastname: Ipekci
authors.affiliation: Department of Urology, Antalya Training and Research Hospital Antalya, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Yildiz
authors.affiliation: Department of Urology, Antalya State Hospital Antalya, Turkey.
authors.forename: Nihat
authors.initials: N
authors.lastname: Ates
authors.affiliation: Department of Urology, Antalya Training and Research Hospital Antalya, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Savas
keywords: Medical expulsive therapy; alpha blocker; renal colic; silodosin; ureteral calculi; ureteral stone