title: Bicalutamide causes heart failure in an elderly patient with prostate cancer.
abstract: OBJECTIVE
  To examine the molecular mechanisms by which bicalutamide may cause heart failure in an elderly patient.
  
  
  METHODS
  Retrospective analysis of bicalutamide as a cause of heart failure in Mr FD, an 82 years old with prostate cancer.
  
  
  RESULTS
  Following months of therapy, Mr FD was diagnosed with heart failure. Bicalutamide has been ceased, but 21 months later, Mr FD was still on heart failure medications, and passed away months later probably due to complications of prostate cancer. The Naranjo ADR probability scale gave this case a score of seven.
  
  
  CONCLUSIONS
  The Naranjo scale strongly suggests that bicalutamide was the cause of heart failure. Apoptosis seems to be one of the mechanisms mediating heart failure, with the involvement of many molecular actors, such as ET-1, Bcl-2 and cyclin-A. The author believes this to be the first analysis describing bicalutamide as a probable cause of heart failure.
authors.affiliation: a HARP Medication Management , St Vincent's Hospital , Fitzroy , Australia.
authors.forename: Kyrillos
authors.initials: K
authors.lastname: Guirguis
mesh_terms: D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D000813:Anilides / Q000009:adverse effects* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D006333:Heart Failure / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009570:Nitriles / Q000009:adverse effects* / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D014105:Tosyl Compounds / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000726:Androgen Antagonists; D000813:Anilides; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide
keywords: Adverse drug reaction; Bicalutamide; apoptosis; elderly; heart failure; prostate cancer