title: Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature.
abstract: The autotaxin-lysophophatidic acid (ATX-LPA) signaling pathway is implicated in a variety of human disease states including angiogenesis, autoimmune diseases, cancer, fibrotic diseases, inflammation, neurodegeneration, and neuropathic pain, among others. As a result, ATX-LPA has become of significant interest within both the industrial and the academic communities. This review aims to provide a concise overview of the development of novel ATX inhibitors, including the disclosure of the first ATX clinical trial data.
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde , Glasgow, G1 1XL, U.K.
authors.forename: Diana
authors.initials: D
authors.lastname: Castagna
authors.affiliation: Medicines Research Centre, GlaxoSmithKline , Gunnel Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
authors.forename: David C
authors.initials: DC
authors.lastname: Budd
authors.affiliation: Medicines Research Centre, GlaxoSmithKline , Gunnel Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
authors.forename: Simon J F
authors.initials: SJ
authors.lastname: Macdonald
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde , Glasgow, G1 1XL, U.K.
authors.forename: Craig
authors.initials: C
authors.lastname: Jamieson
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde , Glasgow, G1 1XL, U.K.
authors.forename: Allan J B
authors.initials: AJ
authors.lastname: Watson
mesh_terms: D001583:Benzoxazoles / Q000737:chemistry / Q000494:pharmacology*; D001897:Boronic Acids / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D013329:Structure-Activity Relationship; D000099189:Lysophospholipase D
chemical_list: D001583:Benzoxazoles; D001897:Boronic Acids; D004791:Enzyme Inhibitors; D010727:Phosphoric Diester Hydrolases; D000099189:Lysophospholipase D; C017057:benzoxazolone