title: Effects of Dietary Selenium Against Lead Toxicity Are Related to the Ion Profile in Chicken Muscle.
abstract: Complex antagonistic interactions between Selenium (Se) and heavy metals have been reported in previous studies. However, little is known regarding the effects of Se on lead (Pb)-induced toxicity and the ion profile in the muscles of chickens. In this present study, we fed chickens either Se or Pb or both Se and Pb supplement and later analyzed the concentrations of 26 ions in chicken muscle tissues. We determined that a Se- and Pb-containing diets significantly affected microelements in chicken muscle. Treatment with Se increased the content of Se but resulted in a reduced concentration of Cu, As, Cd, Sn, Hg, and Ba. Treatment with Pb increased concentrations of Ni while reducing those of B, V, Cr, Fe, Co, Cu, Zn, and Mo. Moreover, Se also reduced the concentration of Pb, Zn, Co, Fe, V, and Cr, which in contrast were induced by Pb. Additionally, we also found that synergistic and antagonistic interactions existed between Se and Pb supplementation. Our findings suggested that Se can exert a negative effect on Pb in chicken muscle tissues and may be related to changes in ion profiles.
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
authors.forename: Xi
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
authors.forename: Chun Peng
authors.initials: CP
authors.lastname: Liu
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China. 364928357@qq.com.
authors.forename: Xiao Hua
authors.initials: XH
authors.lastname: Teng
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China. jf699@cornell.edu.|Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14850, USA. jf699@cornell.edu.
authors.forename: Jing
authors.initials: J
authors.lastname: Fu
mesh_terms: D000818:Animals; D002645:Chickens / Q000378:metabolism*; D019587:Dietary Supplements; D007477:Ions / Q000378:metabolism; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D007477:Ions; D007854:Lead; D012643:Selenium
keywords: Chicken muscle; Ion profiles; Lead; Selenium