title: The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice.
abstract: Acute respiratory distress syndrome (ARDS),which is inflammatory disorder of the lung, which is caused by pneumonia, aspiration of gastric contents, trauma and sepsis, results in widespread lung inflammation and increased pulmonary vascular permeability. Its pathogenesis is complicated and the mortality is high. Thus, there is a tremendous need for new therapies. We have reported that HJB-1, a 17-hydroxy-jolkinolide B derivative, exhibited strong anti-inflammatory effects in vitro. In this study, we investigated its impacts on LPS-induced ARDS mice. We found that HJB-1 significantly alleviated LPS-induced pulmonary histological alterations, inflammatory cells infiltration, lung edema, as well as the generation of inflammatory cytokines TNF-α, IL-1β and IL-6 in BALF. In addition, HJB-1 markedly suppressed LPS-induced IκB-α degradation, nuclear accumulation of NF-κB p65 subunit and MAPK phosphorylation. These results suggested that HJB-1 improved LPS-induced ARDS by suppressing LPS-induced NF-κB and MAPK activation.
authors.affiliation: Central Laboratory, The Second Clinical Hospital, Jilin University, Changchun 130041, China. xuxiaohan2015@outlook.com.|Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun 130062, China. xuxiaohan2015@outlook.com.|School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. xuxiaohan2015@outlook.com.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Xu
authors.affiliation: Central Laboratory, The Second Clinical Hospital, Jilin University, Changchun 130041, China. liu_ning@jlu.edu.cn.
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.affiliation: Key Laboratory of Molecular Enzymology &amp; Engineering, Ministry of Education, College of Life Science, Jilin University, Changchun 130012, China. chongfengxing@163.com.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Zhang
authors.affiliation: Central Laboratory, The Second Clinical Hospital, Jilin University, Changchun 130041, China. jinjincao90@163.com.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Cao
authors.affiliation: Jilin Provincial Center for Disease Control and Prevention, Changchun 130062, China. dl_wu@163.com.
authors.forename: Donglin
authors.initials: D
authors.lastname: Wu
authors.affiliation: Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun 130062, China. qishengpeng@yahoo.com.
authors.forename: Qisheng
authors.initials: Q
authors.lastname: Peng
authors.affiliation: School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. hbwang@tongji.edu.cn.
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Wang
authors.affiliation: Central Laboratory, The Second Clinical Hospital, Jilin University, Changchun 130041, China. wanchunsun@jlu.edu.cn.|Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun 130062, China. wanchunsun@jlu.edu.cn.
authors.forename: Wan-Chun
authors.initials: WC
authors.lastname: Sun
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004195:Disease Models, Animal; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal; D004789:Enzyme Activation / Q000187:drug effects; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism; D007274:Injections, Intraperitoneal; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000276:immunology; D015850:Interleukin-6 / Q000096:biosynthesis / Q000276:immunology; D008070:Lipopolysaccharides; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000276:immunology; D000093242:Interleukin-6 Inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D051550:I-kappa B Kinase; D053583:Interleukin-1beta; D015850:Interleukin-6; D008070:Lipopolysaccharides; D020929:Mitogen-Activated Protein Kinase Kinases; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors; C577686:interleukin-6, mouse
keywords: 17-hydroxy-jolkinolide B; Acute respiratory distress syndrome (ARDS); MAPK; NF-κB; edema