title: Assessment of heat shock proteins and endothelial dysfunction in acute pulmonary embolism.
abstract: We determined the levels of some heat shock proteins (HSP27, HSP70, and HSP90), L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) levels in patients with acute pulmonary embolism. The present case-control study comprised a healthy control group (n = 57) and patients with acute pulmonary embolism (n = 84). HSPs, L-arginine, ADMA, and SDMA levels were measured in all of the cases. The mean age of the control group was 56.72 ± 8.44 years, and the mean age of the patients with acute pulmonary embolism was 60.20 ± 16.56 years (P = 0.104). Compared with controls, patients with acute pulmonary embolism had significantly higher mean serum HSP27, HSP90, and ADMA levels, whereas the mean serum L-arginine and SDMA levels were lower (P < 0.001, for all parameters). In patients with acute pulmonary embolism serum HSP27, HSP70, and ADMA levels were negatively correlated with partial pressures of arterial oxygen levels (r = -0.281, P = 0.01; r = -0.263, P = 0.016; and r = -0.275, P = 0.011, respectively) and arterial oxygen saturation (r = -0.225, P = 0.039; r = -0.400, P < 0.001; r = -0.299, P = 0.006, respectively). The findings of the present study demonstrated that oxidative stress and endothelial damage increase in acute pulmonary embolism.
authors.affiliation: aDepartment of Chest DiseasesbDepartment of Biochemistry and Clinical Biochemistry, Firat University Faculty of Medicine, Elazig, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: İn
authors.forename: Figen
authors.initials: F
authors.lastname: Deveci
authors.forename: Dilara
authors.initials: D
authors.lastname: Kaman
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D055551:HSP27 Heat-Shock Proteins / Q000097:blood* / Q000235:genetics; D018840:HSP70 Heat-Shock Proteins / Q000097:blood* / Q000235:genetics; D018841:HSP90 Heat-Shock Proteins / Q000097:blood* / Q000235:genetics; D006360:Heat-Shock Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D011651:Pulmonary Artery / Q000378:metabolism* / Q000473:pathology; D011655:Pulmonary Embolism / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology
chemical_list: D015415:Biomarkers; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine; D010100:Oxygen