title: (68)Ga-DOTATOC-PET/CT for effective diagnosis and treatment of pancreatic tail gastrinoma with multiple liver metastases: a case report.
abstract: A 40-year-old man admitted to our hospital with diarrhea underwent abdominal computed tomography (CT) which showed multiple masses in the liver and pancreatic tail. Although there were no abnormal accumulations with fluorodeoxyglucose ((18)F) positron emission tomography (FDG-PET), (68)Ga-DOTATOC-PET/CT detected obvious abnormal accumulations for the both lobes of liver and pancreatic tail tumors. The serum gastrin was markedly high, and liver tumor biopsy demonstrated the presence of malignant cells with round nuclei that were positive for gastrin and somatostatin receptor. The patient was diagnosed with pancreatic tail gastrinoma with multiple liver metastases and treated with octreotide, everolimus, and a proton pump inhibitor which functionally controlled tumor growth. This case demonstrates (68)Ga-DOTATOC-PET/CT as a useful modality for the localization, qualitative diagnosis, and treatment of gastrinoma.
authors.affiliation: Department of Gastroenterology, Japanese Red Cross Kyoto Daiichi Hospital.
authors.forename: Shinya
authors.initials: S
authors.lastname: Matsumura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Okuyama
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Doi
authors.forename: Ryuta
authors.initials: R
authors.lastname: Nakao
authors.forename: Yoji
authors.initials: Y
authors.lastname: Urata
authors.forename: Norimasa
authors.initials: N
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000068338:Everolimus / Q000008:administration & dosage; D005710:Gallium Radioisotopes; D015408:Gastrinoma / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary; D008297:Male; D015282:Octreotide / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D000072078:Positron Emission Tomography Computed Tomography; D016896:Treatment Outcome
chemical_list: D005710:Gallium Radioisotopes; D000068338:Everolimus; D015282:Octreotide