title: [The Influence of Flurbiprofen on the Frequency of Postoperative Shivering].
abstract: BACKGROUND
  Many methods to prevent postoperative shivering (POS) has been reported. However, there are few reports demonstrating the effect of flurbiprofen on POS which affects the set point in the thermocenter of the hypothalamus.
  
  
  METHODS
  One hundred and forty six patients undergoing lung lobectomy or segmentectomy under video-assisted thoracic surgery were divided into a flurbiprofen-treated group (Group F) and a non-treated group (Group N). We retrospectively investigated the incidence of POS associated with total intravenous anesthesia with epidural anesthesia compared with or without flurbiprofen. We weighed the incidence of POS against age, body mass index, the effective site concentration of fentanyl on extubation, the mean dose of remifentanil, the minimum rectal temperature, the surgical duration and total hemorrhage volume based on the anesthetic chart Chi-square and Student t-test were used for statistical analysis.
  
  
  RESULTS
  Although the surgical duration in Group F was shorter than that in Group N (223±83 vs. 165±80 (min), P<0.01), the incidence of POS in Group F was higher than that in Group N (1/32 vs. 28/114, P<0.01). There were no significant differences in another items between the two groups.
  
  
  CONCLUSIONS
  The results of the study indicates that flurbiprofen has a possible beneficial effect in preventing POS.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Urabe
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Nakanuno
authors.forename: Kazuma
authors.initials: K
authors.lastname: Hayase
authors.forename: Nanako
authors.initials: N
authors.lastname: Takata
authors.forename: Masaki
authors.initials: M
authors.lastname: Senami
mesh_terms: D000368:Aged; D005480:Flurbiprofen / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D012189:Retrospective Studies; D012768:Shivering / Q000187:drug effects*; D020775:Thoracic Surgery, Video-Assisted
chemical_list: D005480:Flurbiprofen