title: [Update 2016 - Immunotherapy for urothelial carcinoma].
abstract: Advanced urothelial carcinoma of the bladder is an aggressive tumor with a poor prognosis. Besides surgical therapy, classical chemotherapy with platinum compounds is the mainstay of advanced bladder cancer treatment. In recent years, immune modulating therapies have come into the focus of clinical trials. This review provides an overview of the biological mechanisms and immuno-oncological drugs that are currently being analyzed in clinical trials as well as established standard therapies.
authors.affiliation: Urologische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Retz
authors.affiliation: Urologische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Deutschland.
authors.forename: J E
authors.initials: JE
authors.lastname: Gschwend
authors.affiliation: Urologische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Deutschland. sebastian.schmid@tum.de.
authors.forename: S C
authors.initials: SC
authors.lastname: Schmid
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D007167:Immunotherapy / Q000639:trends*; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*
chemical_list: D019496:Cancer Vaccines
keywords: Bladder cancer; Chemotherapy; Clinical trials; Immunotherapy; Urothelial cancer