title: [COMPARISON OF PERIOPERATIVE INFLAMMATORY MARKERS BETWEEN PATIENTS WITH ANKYLOSING SPONDYLITIS AND NON-INFLAMMATORY DISEASES UNDERGOING TOTAL HIP ARTHROPLASTY].
abstract: OBJECTIVE
  To evaluate the inflammatory markers in patients with ankylosing spondylitis (AS) or non-inflammatory diseases undergoing total hip arthroplasty (THA) and to ascertain the variation trend of perioperative inflammatory markers and the influence of inflammation markers after THA.
  
  
  METHODS
  Between January 2013 and December 2014, 153 consecutive patients with AS were included. According to the range of motion (ROM), the patients were divided into ankylosis group (ROM: 0 degrees; group A, n = 92) and stiff group (ROM: 3-46 degrees; group B, n = 61); 120 non-inflammatory diseases patients having no bacterial infection and undergoing primary THA served as non-inflammatory group (group C). The inflammatory markers including C-reactive protein (CRP), interleukin-6 (IL-6), and erythrocyte sedimentation rate (ESR) concentrations were measured before operation and at 1, 3, 5, and 7 days after operation, and the complication was observed.
  
  
  RESULTS
  Perioperative serum CRP, IL-6, and ESR increased at first after operation, and then decreased in 3 groups. There were significant differences in CRP and ESR between at pre- and post-operation (P < 0.05); the IL-6 at 1, 3, and 5 days after operation were significantly higher than that at preoperation (P<0.05), but no significant difference was found between at 7 days and at preoperation (P > 0.05). CRP, IL-6, and ESR of group B were significantly higher than those of group A at preoperation (P < 0.05); CRP and IL-6 of groups A and B were significantly higher than those of group C at preoperation and at 1 day after operation (P < 0.05); ESR of groups A and B was significantly higher than that of group C at preoperation, and at 1 day and 3 days after operation (P < 0.05); and no significant difference was shown among 3 groups at the other time points (P > 0.05). No inflammatory activity or increased complication was observed.
  
  
  CONCLUSIONS
  AS and non-inflammatory diseases show similar change trend of inflammatory markers at pre- and post-operation. The inflammatory activity of AS has no significant effect on the changes of inflammation markers and does not increase the incidence of postoperative complications.
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Qingmeng
authors.initials: Q
authors.lastname: Zhang
authors.forename: Heng
authors.initials: H
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Chi
authors.initials: C
authors.lastname: Xu
authors.forename: Jiying
authors.initials: J
authors.lastname: Chen
mesh_terms: D019644:Arthroplasty, Replacement, Hip; D015415:Biomarkers / Q000097:blood*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000378:metabolism; D011183:Postoperative Complications; D011859:Radiography; D016059:Range of Motion, Articular; D013167:Spondylitis, Ankylosing / Q000000981:diagnostic imaging / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein