title: Overexpression of CSF-1R in nasopharyngeal carcinoma.
abstract: BACKGROUND
  Tumor-associated macrophages play a significant role in tumor progression. CSF-1/CSF-1R is one of the most primary regulators of macrophage physiology in immune system. The expression of CSF-1/CSF-1R in nasopharyngeal carcinoma is unclear.
  
  
  OBJECTIVE
  The aim of this study was to compare the expression of CSF-1R in nasopharyngeal carcinoma to nasopharyngitis for assessing the role CSF-1/CSF-1R in nasopharyngeal carcinoma.
  
  
  METHODS
  Diagnostic tissues from 56 nasopharyngeal carcinoma patients and 32 nasopharyngitis patients were evaluated retrospectively by immunohistochemical analysis for the expression of CSF-1R.
  
  
  RESULTS
  Significant differences of CSF-1R expression exists between nasopharyngeal carcinoma patients and nasopharyngitis patients (p<0.001). However, there is no relevance between CSF-1R and worse survival.
authors.affiliation: Cancer Center, Renmin Hospital of Wuhan University, People's Hospital of Guangxi Autonomous Region, China; whuxxm@yahoo.com, yanronghao.2008@aliyun.com.
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.forename: Ximing
authors.initials: X
authors.lastname: Xu
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Hao
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Junping
authors.initials: J
authors.lastname: Cheng
authors.forename: Zhaohong
authors.initials: Z
authors.lastname: Chen
authors.forename: Wuqing
authors.initials: W
authors.lastname: Liang
authors.forename: Jiao
authors.initials: J
authors.lastname: Yang
authors.forename: Wen
authors.initials: W
authors.lastname: Ao
authors.forename: Xin
authors.initials: X
authors.lastname: Hao
authors.forename: Weiwei
authors.initials: W
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009304:Nasopharyngitis / Q000378:metabolism / Q000473:pathology; D009362:Neoplasm Metastasis; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D016186:Receptor, Macrophage Colony-Stimulating Factor