title: Induction of autoimmune gastritis by neonatal thymectomy requires autoantibodies and is prevented by anti-FcγR antibodies.
abstract: The autoantibodies (auto-Abs) that are a hallmark of neonatally thymectomized (NTx) mice with autoimmune gastritis (AIG) have been poorly explored. We investigated their immune significance using B cell-deficient (B(-)) mice and found that B(-) mice are totally resistant to AIG but become susceptible to AIG after receiving bone marrow cells from B(+) mice. This susceptibility is most likely caused by the production of auto-Abs by B cells because B(-) pups also became susceptible to AIG when nourished by an AIG dam producing auto-Abs of the IgG class during the suckling period. NTx B(-) mice receiving purified IgG auto-Abs at this developmental stage similarly developed AIG. Auto-Abs probably act on antigen handling for antigen presentation because the treatment of NTx B(+) mice with anti-FcγR Abs prevented the development of AIG. Auto-Abs are indispensable for AIG development but are not sufficient because auto-Ab treatment did not increase AIG incidence in NTx B(+) mice above the baseline.
authors.affiliation: Laboratory of Immunobiology, Department of Life Sciences, Graduate School of Science and Technology, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, Japan.
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Saito
authors.affiliation: Laboratory of Immunobiology, Department of Life Sciences, Graduate School of Science and Technology, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Suenaga
authors.affiliation: Laboratory of Immunobiology, Department of Life Sciences, Graduate School of Science and Technology, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Fujii
authors.affiliation: Laboratory of Immunobiology, Department of Life Sciences, Graduate School of Science and Technology, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kushida
authors.affiliation: Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 757 Ichibancho, Asahimachidori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kawauchi
authors.affiliation: Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 757 Ichibancho, Asahimachidori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Biology, Faculty of Science, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, Japan. Electronic address: tomaki@gs.niigata-u.ac.jp.
authors.forename: Maki
authors.initials: M
authors.lastname: Touma
authors.affiliation: Laboratory of Immunobiology, Department of Life Sciences, Graduate School of Science and Technology, Niigata University, 8050 Ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, Japan. Electronic address: hosono@gs.niigata-u.ac.jp.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Hosono
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D000831:Animals, Newborn; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes; D004195:Disease Models, Animal; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D005756:Gastritis / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008817:Mice, Mutant Strains; D017452:Receptors, IgG / Q000037:antagonists & inhibitors / Q000276:immunology*; D013934:Thymectomy
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007074:Immunoglobulin G; D017452:Receptors, IgG
keywords: Anti-FcγR antibodies; Autoantibodies; Autoimmune gastritis; B cell-deficient mice; Neonatal thymectomy