title: Genomic Medicine: Why Do "Similar" Patients Have Different Outcomes?
abstract: Genomic variation is an important factor in why supposedly "similar" patients react differently to drugs, have different disease course(s), and varying clinical outcomes. This review provides an update on concepts in modern genomic medicine with an emphasis on clinically relevant study approaches, disease/drug pathway analysis, and recent pharmacogenomic findings. The application of genomic medicine and its importance for rapid diagnosis of disease-causing agents, as well as its clinical application in human disease diagnosis/treatment and in cardiovascular disease are discussed. In addition to direct clinical applications, modern genomic approaches also play an important role in elucidating new mechanisms of disease. Finally, the role of the National Institutes of Health national pharmacogenomics research network in codifying "bench to bedside" translation of genetic results that impact drug therapy will also be discussed.
authors.affiliation: Department of Anesthesiology & Pain Medicine, Allan J. Treuer Endowed Professor, Adjunct Professor of Pharmacology and Genome Sciences, Box 356540, University of Washington, Seattle, WA 98195-6540, 206-543-2673, dschwinn@uw.edu.
authors.forename: Debra
authors.initials: D
authors.lastname: Schwinn
authors.affiliation: University of Washington, Resident, Department of Anesthesiology & Pain Therapy, Bern, Switzerland, Department of Anesthesiology & Pain Medicine, Box 356540, University of Washington, Seattle, WA 98195-6540, 206-685-7968, marenkb@uw.edu.
authors.forename: Maren
authors.initials: M
authors.lastname: Kleine-Brueggeney
authors.affiliation: Department of Anesthesiology & Pain Medicine, Box 356540, University of Washington, Seattle, WA 98195-6540, 206-685-7520, anush@uw.edu.
authors.forename: Anush
authors.initials: A
authors.lastname: Oganesian