title: Association between Low Estimated Glomerular Filtration Rate and Risk of Cerebral Small-Vessel Diseases: A Meta-Analysis.
abstract: BACKGROUND
  Although chronic kidney disease has been linked to cerebral small-vessel disease (CSVD), a definite relationship between them has not been established. This study assessed whether low estimated glomerular filtration is associated with risk of different subtypes of CSVDs.
  
  
  METHODS
  Electronic databases were systematically searched for studies reporting an odds ratio of the association between low estimated glomerular filtration and CSVD risk. Sixteen studies, including 10,534 participants, were identified. A fix effects model was applied and odds ratios (ORs) with 95% confidence intervals were presented.
  
  
  RESULTS
  Overall, risk of CSVDs was greater in individuals with low estimated glomerular filtration (OR = 2.20). Stratified analyses consistently showed significant associations across different subtypes, with pooled OR being greatest in subjects with silent cerebral infarction (SCI) (OR = 2.71) and cerebral microbleed (OR = 2.70). A pooled estimate of studies showing OR as a continuous variable showed results consistent with the former analysis (OR = .98 per standard deviation decrease) in low estimated glomerular filtration.
  
  
  CONCLUSIONS
  This study revealed that low estimated glomerular filtration was significantly associated with risk of CSVDs. Low estimated glomerular filtration was most strongly associated with SCI (OR = 2.71) among subtypes of CSVDs.
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Pu
authors.initials: P
authors.lastname: Lv
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Haiqiang
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.affiliation: The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center, Beijing, China.
authors.forename: Chenguang
authors.initials: C
authors.lastname: Niu
authors.affiliation: The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center, Beijing, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Chenghe
authors.initials: C
authors.lastname: Fan
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Teng
authors.affiliation: The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center, Beijing, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Pan
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Peng
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Luo
authors.affiliation: The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center, Beijing, China. Electronic address: zhengl@bjmu.edu.cn.
authors.forename: Lemin
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China. Electronic address: ynhuang@sina.com.
authors.forename: Yining
authors.initials: Y
authors.lastname: Huang
mesh_terms: D059345:Cerebral Small Vessel Diseases / Q000150:complications* / Q000453:epidemiology*; D016208:Databases, Factual / Q000706:statistics & numerical data; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D016017:Odds Ratio; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology
keywords: Cerebral small-vessel diseases; chronic kidney impairment; estimated glomerular filtration rate; meta-analysis