title: Nonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trial.
abstract: In order to evaluate whether nonsurgical periodontal treatment with/without diode laser (DL) decontamination improves clinical parameters, the levels of IL-1β, IL-6, IL-8, intercellular adhesion molecule (ICAM), and vascular cell adhesion molecule (VCAM) in gingival crevicular fluid and metabolic control (HbA1c) in chronic periodontitis (CP) patients with diabetes mellitus type 2 (DM2). Sixty patients with DM2 and CP were randomly assigned into two groups to receive scaling and root planing (SRP, n = 30) or SRP followed by diode laser application (SRP + DL, n = 30). Clinical periodontal and gingival crevicular fluid (GCF) parameters were assessed at baseline, 1, and 3 months after periodontal treatment. HbA1c levels were evaluated at baseline and 3 months post-therapy. Total amounts of cytokines and molecules were analyzed by ELISA. Nonsurgical periodontal treatment with/without DL appeared to improve clinical, biochemical parameters, and glycemic control in DM2 patients (BMI < 25 kg/m(2)) with CP. The SRP + DL group provided better reductions in probing depth (PD) and clinical attachment level (CAL) parameters compared to the SRP group (P < 0.05). Significant reductions were found in the total amounts of GCF levels of IL-1, IL-6, IL-8, ICAM, and VCAM after treatment (P < 0.05). HbA1c levels decreased significantly at 3 months after treatment (P < 0.05). SRP + DL reduced HbA1c levels more significantly compared to SRP alone (0.41 vs. 0.22 %, P < 0.05). SRP, especially in combination with DL, shows improvement of glycemic control for DM2 patients with CP.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Selcuk University, Konya, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Koçak
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey. dtmehmetsaglam@gmail.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sağlam
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Karabük University, Karabuk, Turkey.
authors.forename: Seyit Ali
authors.initials: SA
authors.lastname: Kayış
authors.affiliation: Research Center of Dental Faculty, Selcuk University, Konya, Turkey.
authors.forename: Niyazi
authors.initials: N
authors.lastname: Dündar
authors.affiliation: Department of Endocrinology and Metabolism Disease, School of Medicine, Selcuk University, Konya, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Kebapçılar
authors.affiliation: Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
authors.forename: Bruno G
authors.initials: BG
authors.lastname: Loos
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Selcuk University, Konya, Turkey.|Research Center of Dental Faculty, Selcuk University, Konya, Turkey.
authors.forename: Sema S
authors.initials: SS
authors.lastname: Hakkı
mesh_terms: D000328:Adult; D055113:Chronic Periodontitis / Q000150:complications / Q000378:metabolism* / Q000601:surgery* / Q000628:therapy; D016207:Cytokines / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D016745:Root Planing / Q000379:methods*
chemical_list: D016207:Cytokines
keywords: Cell adhesion molecules; Chronic periodontitis; Cytokines; Diabetes mellitus; Diode lasers; Metabolic control; Nonsurgical periodontal debridement