title: New Phragmalin-Type Limonoids from Chukrasia tabularis and Their α-Glucosidase Inhibitory Activity.
abstract: Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1-5, named chukbularisins A-E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro α-glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against α-glucosidase with IC50 values of 0.06 ± 0.008, 0.04 ± 0.002, 0.52 ± 0.039, 1.09 ± 0.040, and 0.20 ± 0.057 mM, respectively (using acarbose as positive control, IC50 0.95 ± 0.092 mM).
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. peng900923@163.com.|College of Pharmacy and Chemistry, Dali University, Dali 671000, China. peng900923@163.com.
authors.forename: Jun-Lin
authors.initials: JL
authors.lastname: Peng
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. wanghuanlong@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. kongfandong@itbb.org.cn.
authors.forename: Fan-Dong
authors.initials: FD
authors.lastname: Kong
authors.affiliation: College of Pharmacy and Chemistry, Dali University, Dali 671000, China. xiguaxue@163.com.
authors.forename: Zi-Qi
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. wangpei@itbb.org.cn.
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. narutocn118@163.com.
authors.forename: Cui-Juan
authors.initials: CJ
authors.lastname: Gai
authors.affiliation: College of Pharmacy and Chemistry, Dali University, Dali 671000, China. dalinorthjiang@163.com.
authors.forename: Bei
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. meiwenli@itbb.org.cn.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. daihaofu@itbb.org.cn.
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification; D059625:Liquid-Liquid Extraction / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D013329:Structure-Activity Relationship; D000520:alpha-Glucosidases / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D036701:Limonins; C000593079:phragmalin; D000520:alpha-Glucosidases
keywords: Chukrasia tabularis; Meliaceae; limonoid; α-Glucosidase inhibition activity