title: Can Insulin Production Suppress β Cell Growth?
abstract: While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.
authors.affiliation: Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom.
authors.forename: Matias
authors.initials: M
authors.lastname: De Vas
authors.affiliation: Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom; Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona, Spain. Electronic address: jferrerm@imperial.ac.uk.
authors.forename: Jorge
authors.initials: J
authors.lastname: Ferrer
mesh_terms: D002453:Cell Cycle; D049109:Cell Proliferation / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000378:metabolism*
chemical_list: D007328:Insulin; D007334:Insulin-Like Growth Factor I