title: Cardiomyocyte Autophagia and Morphological Alterations in the Left Ventricular Myocardium during Acute Focal Ischemia.
abstract: In experiments on rabbits we evaluated the intensity of cardiomyocyte autophagia by the level beclin-1 protein and morphology of the left ventricular myocardium on days 1, 3, and 5 after the onset of focal ischemia caused by ligation of the descending branch of the left coronary artery. The morphological alterations in the left ventricular myocardium were accompanied by intensification of cardiomyocyte autophagia, which attained maximum on postligation day 1.
authors.affiliation: Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship, Moscow, Russia. blagonravovm@mail.ru.
authors.forename: M L
authors.initials: ML
authors.lastname: Blagonravov
authors.affiliation: Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Korshunova
authors.affiliation: Department of Biology and General Genetics, Medical Institute of Russian University of People Friendship, Moscow, Russia.
authors.forename: M M
authors.initials: MM
authors.lastname: Azova
authors.affiliation: Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship, Moscow, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Bondar'
authors.affiliation: Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Frolov
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001343:Autophagy / Q000502:physiology; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D011817:Rabbits; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D051017:Apoptosis Regulatory Proteins
keywords: autophagia; beclin-1; cardiomyocyte; focal ischemia; myocardium