title: Association between Carotid Artery Stenosis and Cognitive Impairment in Stroke Patients: A Cross-Sectional Study.
abstract: To investigate potential associations between carotid artery stenosis and cognitive impairment among patients with acute ischemic stroke and to provide important clinical implications. We measured the degree of carotid artery stenosis and recorded the Mini-Mental State Examination score (MMSE) at admission in 3116 acute ischemic stroke patients. The association between carotid stenosis and cognitive impairment assessed by MMSE was tested using multivariate regression analysis. Other clinical variables of interest were also studied. After adjusting for age, gender, education level, marriage, alcohol use, tobacco use, physical activity, hypertension, diabetes, hypercholesterolemia, atrial fibrillation, myocardial infarction and NIHSS (National Institutes of Health Stroke Scale) score, we found that participants with high-grade stenosis of the carotid artery had a higher likelihood of cognitive impairment compared to those without carotid artery stenosis (OR = 1.49, 95%CI: 1.05-2.11, p<0.001). Left common carotid artery stenosis was associated with cognitive impairment in the univariate analysis, although this effect did not persist after adjustment for the NIHSS score. Cognitive impairment was associated with high-grade stenosis of the right carotid artery.
authors.affiliation: Department of Neurology, Second Hospital of Tianjin Medical University, Tianjin, PR China.|Department of Neurology, Tianjin Huanhu Hospital, Tianjin, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yue
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.|Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
authors.forename: Anxin
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Neurology, Inner Mongolia People's Hospital, Inner Mongolia, Hohhot, China.
authors.forename: Runxiu
authors.initials: R
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Jining No.1 People's Hospital, Jining, Shandong, China.
authors.forename: Zhongrui
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Department of Neurology, Yanbian University Hospital, Yanji, Jilin Province, China.
authors.forename: Shouhuan
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of Neurology, Harbin No. 2 Hospital, Harbin, Heilongjiang, China.
authors.forename: Jingwei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, Yili Friendship Hospital, Yili, Xinjiang Provine, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Huo
authors.affiliation: Department of Neurology, Taian City Central Hospital, Taian, Shandong Province, China.
authors.forename: Yunlin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology, Second Hospital of Tianjin Medical University, Tianjin, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ji
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D017536:Carotid Artery, Common / Q000503:physiopathology*; D016893:Carotid Stenosis / Q000150:complications* / Q000175:diagnosis; D003072:Cognition Disorders / Q000150:complications* / Q000175:diagnosis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D016017:Odds Ratio; D018384:Oxidative Stress; D010343:Patient Admission; D011446:Prospective Studies; D012042:Registries; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications* / Q000175:diagnosis; D055815:Young Adult