title: Abnormal default-mode network homogeneity and its correlations with personality in drug-naive somatization disorder at rest.
abstract: BACKGROUND
  While the default-mode network (DMN) appears to play a crucial role in patients suffering from somatization disorder (SD), the abnormalities of the network homogeneity (NH) of the DMN in SD patients have been poorly explored. The aim of this study is to examine DMN NH using an NH approach in patients suffering from SD at rest and determine its correlations with personality as measured by the Eysenck Personality Questionnaire (EPQ).
  
  
  METHODS
  A total of 25 drug-naive patients with SD and 28 sex-, age-, and education-matched healthy controls underwent functional magnetic resonance imaging scans at rest. The data were analyzed by an automated NH method.
  
  
  RESULTS
  Patients showed increased NH in the left superior frontal gyrus and decreased NH in the bilateral precuneus. Moreover, a significantly negative correlation was observed between the NH values in the bilateral precuneus and the EPQ--Neuroticism scores.
  
  
  CONCLUSIONS
  The present study should be considered preliminary due to a lenient, uncorrected threshold of p<0.01.
  
  
  CONCLUSIONS
  The results suggest that abnormal DMN NH exists in drug-naive SD and further highlight the importance of the DMN in the pathophysiology of SD.
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Shubao
authors.initials: S
authors.lastname: Wei
authors.affiliation: Mental Health Institute, The 303rd Hospital of Chinese People's Liberation Army, Nanning, Guangxi 530021, China.
authors.forename: Qinji
authors.initials: Q
authors.lastname: Su
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Muliang
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Yao
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Liling
authors.initials: L
authors.lastname: Long
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Miaoyu
authors.initials: M
authors.lastname: Yu
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: guowenbin76@163.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology*; D000075384:Neuroticism; D010296:Parietal Lobe / Q000503:physiopathology; D010551:Personality / Q000502:physiology*; D010555:Personality Inventory; D017397:Prefrontal Cortex / Q000503:physiopathology; D012146:Rest / Q000502:physiology*; D013001:Somatoform Disorders / Q000503:physiopathology*
keywords: Eysenck Personality Questionnaire; Network homogeneity; Precuneus; Somatization disorder; Superior frontal gyrus