title: Re-Use of Established Drugs for Anti-Metastatic Indications.
abstract: Most patients that die from cancer do not die due to the primary tumor but due to the development of metastases. However, there is currently still no drug on the market that specifically addresses and inhibits metastasis formation. This lack was, in the past, largely due to the lack of appropriate screening models, but recent developments have established such models and have provided evidence that tumor cell migration works as a surrogate for metastasis formation. Herein we deliver on several examples a rationale for not only testing novel cancer drugs by use of these screening assays, but also reconsider established drugs even of other fields of indication.
authors.affiliation: MetaVì Labs Inc., 16238 Ranch Road 620 North, Suite F-347, Austin, TX 78717, USA. fentschladen@metavilabs.com.|Faculty of Health-School of Medicine, Witten/Herdecke University, Alfred-Herrhausen-Straße 50, 58448 Witten, Germany. fentschladen@metavilabs.com.
authors.forename: Frank
authors.initials: F
authors.lastname: Entschladen
authors.affiliation: MetaVì Labs Inc., 16238 Ranch Road 620 North, Suite F-347, Austin, TX 78717, USA. athyssen@metavilabs.com.
authors.forename: Dane A
authors.initials: DA
authors.lastname: Thyssen
authors.affiliation: MetaVì Labs Inc., 16238 Ranch Road 620 North, Suite F-347, Austin, TX 78717, USA. ddrell@metavilabs.com.
authors.forename: David W
authors.initials: DW
authors.lastname: Drell
keywords: cancer; cell migration; drug screening; metastasis