title: Dissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup.
abstract: The global distribution of J2-M172 sub-haplogroups has been associated with Neolithic demic diffusion. Two branches of J2-M172, J2a-M410 and J2b-M102 make a considerable part of Y chromosome gene pool of the Indian subcontinent. We investigated the Neolithic contribution of demic dispersal from West to Indian paternal lineages, which majorly consists of haplogroups of Late Pleistocene ancestry. To accomplish this, we have analysed 3023 Y-chromosomes from different ethnic populations, of which 355 belonged to J2-M172. Comparison of our data with worldwide data, including Y-STRs of 1157 individuals and haplogroup frequencies of 6966 individuals, suggested a complex scenario that cannot be explained by a single wave of agricultural expansion from Near East to South Asia. Contrary to the widely accepted elite dominance model, we found a substantial presence of J2a-M410 and J2b-M102 haplogroups in both caste and tribal populations of India. Unlike demic spread in Eurasia, our results advocate a unique, complex and ancient arrival of J2a-M410 and J2b-M102 haplogroups into Indian subcontinent.
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Sakshi
authors.initials: S
authors.lastname: Singh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Singh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Raja
authors.initials: R
authors.lastname: Rajkumar
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Katakam
authors.initials: K
authors.lastname: Sampath Kumar
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Subburaj
authors.initials: S
authors.lastname: Kadarkarai Samy
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Sheikh
authors.initials: S
authors.lastname: Nizamuddin
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Amita
authors.initials: A
authors.lastname: Singh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Shahnawaz
authors.initials: S
authors.lastname: Ahmed Sheikh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Vidya
authors.initials: V
authors.lastname: Peddada
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Vinee
authors.initials: V
authors.lastname: Khanna
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Pandichelvam
authors.initials: P
authors.lastname: Veeraiah
authors.affiliation: Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, Netherlands.
authors.forename: Aridaman
authors.initials: A
authors.lastname: Pandit
authors.affiliation: Evolutionary Biology Group, Estonian Biocentre, Tartu, Estonia.
authors.forename: Gyaneshwer
authors.initials: G
authors.lastname: Chaubey
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Lalji
authors.initials: L
authors.lastname: Singh
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.
authors.forename: Kumarasamy
authors.initials: K
authors.lastname: Thangaraj
mesh_terms: D002877:Chromosomes, Human; D041322:Chromosomes, Human, Y; D005828:Genetics, Population; D005843:Geography; D006239:Haplotypes; D006801:Humans; D007194:India; D010802:Phylogeny; D058974:Phylogeography