title: Associated Markers for Adult-onset Allergic Asthma.
abstract: The clinical behavior of asthma varies with age at onset. This study was undertaken to identify associated markers of adult-onset allergic asthma (age ≥20 years).This cross-sectional study compared two groups: 58 patients with asthma onset at ≥20 years and 66 with onset at ≥20 years. They were compared depending on results of clinical history, and body mass index (BMI), aeroallergen sensitization, total serum IgE, eosinophil count, asthma control test, and asthma severity level.Ages at first asthma episode were 10.0 ± 6.6 and 33.4 ± 10.5 (p<0.001) in the <20 and ≥20 group, respectively. BMI was higher in adult asthmatic subjects (29.8 versus 27.1, P=0.017), but BMI ≥30 kg/m(2) was not associated with asthma onset in ≥20 years (odds ratio [OR] = 1.56, 95% confidence interval [CI] 0.759 to 3.211; p= 0.227). After multivariate analysis, allergic rhinitis and IgE ≥150 IU/mL were negatively correlated with asthma onset in ≥20 years old (OR adjusted [ORa] = 0.255, 95% CI 0.078 to 0.837, P= 0.024, and ORa =0.385, 95% CI 0.175 to 0.849, p= 0.018, respectively).Adult-onset allergic asthma was not different from early-onset asthma.
authors.affiliation: Allergy and Clinical Immunology Service, Division of Internal Medicine, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Guadalajara, Jalisco, Mexico.
authors.forename: Martín
authors.initials: M
authors.lastname: Bedolla-Barajas
authors.affiliation: Instituto de Salud Pública, Universidad Veracruzana, Xalapa,Veracruz, Mexico.
authors.forename: Jaime
authors.initials: J
authors.lastname: Morales-Romero
authors.affiliation: Universidad Guadalajara Lamar, Guadalajara, Jalisco, Mexico.
authors.forename: Tonatiuh
authors.initials: T
authors.lastname: Ramses-Bedolla-Pulido
authors.affiliation: Medical Doctor. Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Fabiola-García-Padilla
authors.affiliation: Head of Research, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Guadalajara, Jalisco, Mexico.
authors.forename: Dante
authors.initials: D
authors.lastname: Hernández-Colín
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001249:Asthma / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology; D015415:Biomarkers; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000276:immunology; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000276:immunology; D004802:Eosinophilia / Q000453:epidemiology* / Q000276:immunology; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology / Q000276:immunology; D005541:Forced Expiratory Volume; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D050177:Overweight / Q000453:epidemiology; D065631:Rhinitis, Allergic / Q000453:epidemiology / Q000276:immunology; D013147:Spirometry; D014797:Vital Capacity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007073:Immunoglobulin E
keywords: Adult; Asthma; Biological markers; Immunoglobulin E