title: Surgical treatment of Langerhans cell histiocytosis of cervical spine: case report and review of literature.
abstract: BACKGROUND
  Langerhans cell histiocytosis (LCH) is a rare condition, and even rare is cervical spine involvement.
  
  
  METHODS
  A 9-year-old girl had neck pain, neck tilt and left upper limb weakness, occasional fever and positive family history of tuberculosis. Imaging showed C5 vertebral body collapse with epidural and prevertebral soft tissue collection causing cord and nerve root compression. The patient underwent C5 corpectomy and fusion. Histopathological was suggestive of LCH. She underwent radiotherapy and was asymptomatic at 1-year follow-up.
  
  
  CONCLUSIONS
  Despite the rarity of the condition, the possibility of LCH should be considered in such cases. When neurologic deficits are present, operative treatment should be considered.
authors.affiliation: Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, 560 029, India.
authors.forename: Nishanth
authors.initials: N
authors.lastname: Sadashiva
authors.affiliation: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors.forename: P
authors.initials: P
authors.lastname: Rajalakshmi
authors.affiliation: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors.forename: Anita
authors.initials: A
authors.lastname: Mahadevan
authors.affiliation: Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, 560 029, India.
authors.forename: Vikas
authors.initials: V
authors.lastname: Vazhayil
authors.affiliation: Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, 560 029, India. neuronarsi@gmail.com.
authors.forename: Kannepalli Narasinga
authors.initials: KN
authors.lastname: Rao
authors.affiliation: Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, 560 029, India.
authors.forename: Sampath
authors.initials: S
authors.lastname: Somanna
mesh_terms: D018949:Antigens, CD1 / Q000378:metabolism; D002574:Cervical Vertebrae / Q000601:surgery; D002648:Child; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology*; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen
keywords: Eosinophilic granulomas; Hand-Schüller-Christian disease; Langerhans cell granulomatosis; Letterer-Siwe disease