title: Evaluation of Xpert MTB/RIF for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid.
abstract: Studies investigating Xpert MTB/RIF diagnostic performance on cerebrospinal fluid (CSF) samples are lacking in resource-rich settings. Xpert MTB/RIF results for 740 CSF samples from 698 patients across England were retrospectively compared with the results of culture of the same and contemporary samples. The overall sensitivity was calculated at 55%.
authors.affiliation: Department of Infection, Barts Health, London, United Kingdom NMRL, Public Health England, London, United Kingdom frederick.pink@bartshealth.nhs.uk.
authors.forename: F
authors.initials: F
authors.lastname: Pink
authors.affiliation: NMRL, Public Health England, London, United Kingdom.
authors.forename: T J
authors.initials: TJ
authors.lastname: Brown
authors.affiliation: NMRL, Public Health England, London, United Kingdom Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom National Mycobacterium Reference Laboratory, Research Centre Borstel, Borstel, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Kranzer
authors.affiliation: Department of Infection, Barts Health, London, United Kingdom NMRL, Public Health England, London, United Kingdom Department of Infectious Diseases, Imperial College, London, United Kingdom.
authors.forename: F
authors.initials: F
authors.lastname: Drobniewski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics*; D011933:Reagent Kits, Diagnostic; D012293:Rifampin / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D020306:Tuberculosis, Central Nervous System / Q000175:diagnosis* / Q000382:microbiology*; D055815:Young Adult
chemical_list: D011933:Reagent Kits, Diagnostic; D012293:Rifampin