title: Oxysterols: Synthesis and anti-leishmanial activities.
abstract: Oxygenated sterols (2-16) were synthesized by skeletal rearrangement of steroidal allylic alcohols. All the derivatives were screened for their anti-leishmanial activities. Compounds 3, 11 and 12 showed potent activities. Compound 12 was found least toxic and induced highest nitric oxide (NO) at 48 h. Least toxicity of compound 12 on splenocytes validated its best anti-amastigote effect and induction of NO.
authors.affiliation: Natural Products and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Raja Rammohanpur, Darjeeling 734 013, India. Electronic address: pizy12@yahoo.com.
authors.forename: Pranab
authors.initials: P
authors.lastname: Ghosh
authors.affiliation: Natural Products and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Raja Rammohanpur, Darjeeling 734 013, India.
authors.forename: Ashim
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Natural Products and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Raja Rammohanpur, Darjeeling 734 013, India.
authors.forename: Amitava
authors.initials: A
authors.lastname: Mandal
authors.affiliation: Cellular Immunology and Experimental Therapeutics Laboratory, Department of Zoology, West Bengal State University, Barasat, North 24 PGS, West Bengal 700 126, India.
authors.forename: Sirin Salma
authors.initials: SS
authors.lastname: Sultana
authors.affiliation: Cellular Immunology and Experimental Therapeutics Laboratory, Department of Zoology, West Bengal State University, Barasat, North 24 PGS, West Bengal 700 126, India.
authors.forename: Somaditya
authors.initials: S
authors.lastname: Dey
authors.affiliation: Cellular Immunology and Experimental Therapeutics Laboratory, Department of Zoology, West Bengal State University, Barasat, North 24 PGS, West Bengal 700 126, India.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Pal
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007893:Leishmania donovani / Q000378:metabolism*; D018320:Leishmania major / Q000378:metabolism*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D013261:Sterols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D013261:Sterols
keywords: A-nor-cholest-6-hydroxy-5,7-olide; Anti-leishmanial activities; Cytotoxicity; Oxygenated sterols