title: Patterns of hippocampal atrophy differ among Alzheimer's disease, amnestic mild cognitive impairment, and late-life depression.
abstract: OBJECTIVE
  This study investigated whether the characteristic changes in hippocampal atrophy seen in coronal scans are useful for differentiating Alzheimer's disease (AD), amnestic mild cognitive impairment (aMCI), and major depressive disorder (MDD).
  
  
  METHODS
  Subjects included 58 patients with AD, 33 with aMCI, 20 with MDD, and 22 normal controls, all aged 60 years or older. For each subject, eight coronal short TI inversion recovery images perpendicular to the hippocampal longitudinal axis were obtained. Images were manually measured using the conventional region of interest method of quantitative analysis.
  
  
  RESULTS
  The overall trend in the corrected volumes of the hippocampus was AD < aMCI < MDD < normal controls. We found atrophy in all slices in AD, atrophy centred on the hippocampal head in aMCI, and atrophy in the slice of the hippocampal body 12 mm from the amygdala in MDD.
  
  
  CONCLUSIONS
  The present study suggested that our method of comparing hippocampal atrophy by region may be useful in distinguishing AD, aMCI, MDD, and normal controls.
authors.affiliation: Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.|Department of Psychiatry, National Hospital Organization, Komoro Kogen Hospital, Komoro, Japan.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Joko
authors.affiliation: Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Washizuka
authors.affiliation: Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Daimei
authors.initials: D
authors.lastname: Sasayama
authors.affiliation: Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Inuzuka
authors.affiliation: Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ogihara
authors.affiliation: Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yasaki
authors.affiliation: Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hagiwara
authors.affiliation: Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Sugiyama
authors.affiliation: Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Radiology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kaneko
authors.affiliation: School of Health Sciences, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Tokiji
authors.initials: T
authors.lastname: Hanihara
authors.affiliation: Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Naoji
authors.initials: N
authors.lastname: Amano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D000647:Amnesia / Q000000981:diagnostic imaging / Q000473:pathology*; D001284:Atrophy / Q000000981:diagnostic imaging* / Q000473:pathology; D001931:Brain Mapping; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000473:pathology; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000473:pathology*; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
keywords: Alzheimer's disease; hippocampus; magnetic resonance imaging; major depressive disorder; mild cognitive impairment