title: The Pleiotropic Effect of Glycodelin-A in Early Pregnancy.
abstract: Successful pregnancy depends largely on adequate placentation and maternal tolerance of the fetus. Glycodelin-A is a glycoprotein abundant in the decidua during early pregnancy. It plays an important role in placental development and fetomaternal defense. Glycodelin-A interacts by its unique carbohydrate side chains with the cell surface of various cell types in the human fetomaternal interface, particularly the trophoblasts and the immune cells, and modulates their functions and differentiation to permit successful pregnancy. Abnormal levels of glycodelin-A in the endometrium, uterine flushings, and/or maternal serum correlate with unexplained infertility, early pregnancy loss, and recurrent miscarriage. This review integrates recent studies on the role of glycodelin-A in placental development and fetomaternal tolerance in early pregnancy.
authors.affiliation: Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.|Centre for Reproduction, Development and Growth, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.|Shenzhen Key Laboratory of Fertility Regulation, Department of Obstetrics and Gynecology, The University of Hong Kong-Shenzhen Hospital, Hong Kong, Hong Kong.
authors.forename: Cheuk-Lun
authors.initials: CL
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.|Shenzhen Key Laboratory of Fertility Regulation, Department of Obstetrics and Gynecology, The University of Hong Kong-Shenzhen Hospital, Hong Kong, Hong Kong.
authors.forename: Kevin K W
authors.initials: KK
authors.lastname: Lam
authors.affiliation: Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
authors.forename: Madhavi
authors.initials: M
authors.lastname: Vijayan
authors.affiliation: Department of Clinical Chemistry and Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Hannu
authors.initials: H
authors.lastname: Koistinen
authors.affiliation: Department of Clinical Chemistry and Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Seppala
authors.affiliation: Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.|Centre for Reproduction, Development and Growth, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.|Shenzhen Key Laboratory of Fertility Regulation, Department of Obstetrics and Gynecology, The University of Hong Kong-Shenzhen Hospital, Hong Kong, Hong Kong.
authors.forename: Ernest H Y
authors.initials: EH
authors.lastname: Ng
authors.affiliation: Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.|Centre for Reproduction, Development and Growth, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.|Shenzhen Key Laboratory of Fertility Regulation, Department of Obstetrics and Gynecology, The University of Hong Kong-Shenzhen Hospital, Hong Kong, Hong Kong.
authors.forename: William S B
authors.initials: WS
authors.lastname: Yeung
authors.affiliation: Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.|Centre for Reproduction, Development and Growth, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.|Shenzhen Key Laboratory of Fertility Regulation, Department of Obstetrics and Gynecology, The University of Hong Kong-Shenzhen Hospital, Hong Kong, Hong Kong.
authors.forename: Philip C N
authors.initials: PC
authors.lastname: Chiu
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000276:immunology; D000818:Animals; D003656:Decidua / Q000276:immunology* / Q000378:metabolism; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000097:blood / Q000276:immunology*; D006801:Humans; D007247:Infertility, Female / Q000097:blood; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D011247:Pregnancy / Q000097:blood / Q000276:immunology*; D014327:Trophoblasts / Q000276:immunology* / Q000378:metabolism
chemical_list: D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human
keywords: Fetomaternal tolerance; glycodelin-A; glycosylation; placentation; preeclampsia