title: Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population.
abstract: OBJECTIVE
  The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, in European populations. This study aims to assess the genetic association of the variant rs75932628-T with PD and leucoaraiosis (LA) in a Han Chinese population.
  
  
  METHODS
  This population-based study was conducted in China by Xiamen University and its affiliated hospital.
  
  
  METHODS
  308 patients with LA, 342 patients with PD and 198 healthy blood donors were recruited from the First Affiliated Hospital of Xiamen University.
  
  
  METHODS
  Genotyping was performed by molecular beacon real-time PCR and Sanger sequencing.
  
  
  RESULTS
  None of our participants carried the rs75932628-T mutation.
  
  
  CONCLUSIONS
  Our results corroborate and extend previous findings, concluding that the variant rs75932628-T (p.R47H) in TREM2 is not a risk factor for LA or PD in the Han Chinese population.
authors.affiliation: Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Li
authors.affiliation: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
authors.forename: Long
authors.initials: L
authors.lastname: Gu
authors.affiliation: Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Huang
authors.affiliation: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, China.
authors.forename: Xinzhen
authors.initials: X
authors.lastname: Shi
authors.affiliation: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, China.
authors.forename: Xilin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Xingkai
authors.initials: X
authors.lastname: An
authors.affiliation: Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
authors.forename: Chi-Meng
authors.initials: CM
authors.lastname: Tzeng
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology*; D044466:Asian People / Q000235:genetics*; D002681:China; D005006:Ethnicity; D005260:Female; D005838:Genotype; D006801:Humans; D008060:Lipodystrophy / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D010009:Osteochondrodysplasias / Q000473:pathology; D010300:Parkinson Disease / Q000235:genetics; D011110:Polymorphism, Genetic; D060888:Real-Time Polymerase Chain Reaction; D011971:Receptors, Immunologic / Q000235:genetics*; D013344:Subacute Sclerosing Panencephalitis / Q000473:pathology; D066127:White Matter / Q000473:pathology
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C498715:TREM2 protein, human
keywords: Han Chinese population; Leukoaraiosis; p.R47H; rs75932628-T