title: Scleritis Due to Histoplasmosis.
abstract: OBJECTIVE
  To describe the first-documented case of histoplasma scleritis in an immunocompetent patient.
  
  
  METHODS
  Medical and pathological records of the patient described were reviewed.
  
  
  RESULTS
  A 77-year-old immunocompetent man presented with necrotizing scleritis. Biopsy was consistent with histoplasma species, and culture results confirmed a causative agent of Histoplasma capsulatum. The patient required a long course of treatment, which included topical voriconazole and amphotericin, oral itraconazole and voriconazole, intravenous amphotericin, and periocular voriconazole and amphotericin. After 8 months of treatment, the patient's scleritis resolved, and he maintained good visual acuity.
  
  
  CONCLUSIONS
  To our knowledge, this is the second report of histoplasma scleritis in the literature and the first report in an immunocompetent patient.
authors.affiliation: *Department of Ophthalmology, Mayo Clinic, Rochester, MN; †Thom Eye & Laser Clinic, Fargo, ND; Departments of ‡Laboratory Medicine and Pathology; and §Infectious Disease, Mayo Clinic, Rochester, MN.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Dalvin
authors.forename: Steven B
authors.initials: SB
authors.lastname: Thom
authors.forename: Joaquín J
authors.initials: JJ
authors.lastname: García
authors.forename: Hind J
authors.initials: HJ
authors.lastname: Fadel
authors.forename: Keith H
authors.initials: KH
authors.lastname: Baratz
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D015821:Eye Infections, Fungal / Q000382:microbiology*; D006658:Histoplasma / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000150:complications*; D006801:Humans; D008297:Male; D015423:Scleritis / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents