title: Meta-analysis of diffusion-weighted magnetic resonance imaging in identification of colorectal cancer.
abstract: OBJECTIVE
  This meta-analysis aimed to evaluate the performance of diffusion-weighted magnetic resonance imaging (DWI) in identification of colorectal cancer.
  
  
  METHODS
  A systematic literature search was performed for studies that evaluated the diagnostic accuracy of DWI in identification of colorectal cancer. Methodological quality was assessed by Quality Assessment for Studies of Diagnostic Accuracy 2 (QUADAS 2) tool. After extracting data, we estimated the pooled sensitivity, specificity, likelihood ratios, and constructed summary receiver operating characteristics (SROC) curve.
  
  
  RESULTS
  Ten studies involving 367 malignant lesions and 178 benign lesions were considered eligible after full-text review. The pooled sensitivity and specificity were 0.95 (95% CI: 0.90-0.97) and 0.93 (95% CI: 0.85-0.97), respectively. Positive likelihood ratio and negative likelihood ratio were 12.8 (95% CI: 5.99-27.4) and 0.06 (95% CI: 0.03-0.11), respectively. The area under SROC curve was 0.98.
  
  
  CONCLUSIONS
  Our meta-analysis indicates that DWI is a highly accurate diagnostic method in identification of colorectal cancer.
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu 610041, PR China.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Jia
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityChengdu 610041, PR China; Department of Oncology, West China Hospital, Sichuan UniversityChengdu 610041, PR China.
authors.forename: Xuelei
authors.initials: X
authors.lastname: Ma
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu 610041, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu 610041, PR China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu 610041, PR China.
authors.forename: Rongjun
authors.initials: R
authors.lastname: Liu
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu 610041, PR China.
authors.forename: Zihang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu 610041, PR China.
authors.forename: Jinna
authors.initials: J
authors.lastname: Chen
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu 610041, PR China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Huang
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu 610041, PR China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu 610041, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityChengdu 610041, PR China; Department of Oncology, West China Hospital, Sichuan UniversityChengdu 610041, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
keywords: MRI; colorectal cancer; diffusion magnetic resonance imaging; meta-analysis