title: Microbial stress priming: a meta-analysis.
abstract: Microbes have to cope with complex and dynamic environments, making it likely that anticipatory responses provide fitness benefits. Mild, previous stressors can prepare microbes (stress priming) to further and potentially damaging stressors (triggering). We here quantitatively summarize the findings from over 250 trials of 34 studies including bacteria and fungi, demonstrating that priming to stress has a beneficial impact on microbial survival. In fact, survival of primed microbes was about 10-fold higher compared with that in non-primed microbes. Categorical moderators related to microbial taxonomy and the kind of stress applied as priming or as triggering revealed significant differences of priming effect size among 14 different microbial species, 6 stress categories and stressor combination. We found that priming by osmotic, physiological and temperature stress had the highest positive effect sizes on microbial response. Cross-protection was evident for physiological, temperature and pH stresses. Microbes are better prepared against triggering by oxidative, temperature and osmotic stress. Our finding of an overall positive mean effect of priming regardless of the microbial system and particular stressor provides unprecedentedly strong evidence of the broad ecological significance of microbial stress priming. These results further suggest that stress priming may be an important factor in shaping microbial communities.
authors.affiliation: Plant Ecology, Institut für Biologie, Freie Universität Berlin, Berlin, D-14195, Germany.|Berlin-Brandenburg Institute of Advanced Biodiversity Research (BBIB), Berlin, D-14195, Germany.
authors.forename: Diana R
authors.initials: DR
authors.lastname: Andrade-Linares
authors.affiliation: Plant Ecology, Institut für Biologie, Freie Universität Berlin, Berlin, D-14195, Germany.|Berlin-Brandenburg Institute of Advanced Biodiversity Research (BBIB), Berlin, D-14195, Germany.
authors.forename: Anika
authors.initials: A
authors.lastname: Lehmann
authors.affiliation: Plant Ecology, Institut für Biologie, Freie Universität Berlin, Berlin, D-14195, Germany.|Berlin-Brandenburg Institute of Advanced Biodiversity Research (BBIB), Berlin, D-14195, Germany.
authors.forename: Matthias C
authors.initials: MC
authors.lastname: Rillig
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D001419:Bacteria / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D005658:Fungi / Q000502:physiology*; D009997:Osmotic Pressure / Q000502:physiology*; D013696:Temperature