title: Influence of dioxin exposure upon levels of prostate-specific antigen and steroid hormones in Vietnamese men.
abstract: Most studies on the relationship between Agent Orange and prostate cancer have focused on US veterans of the Vietnam War. There have been few studies focusing on the relationship between levels of prostate-specific antigen (PSA) and dioxins or steroid hormones in Vietnamese men. In 2009-2011, we collected blood samples from 97 men who had resided in a "dioxin hotspot" and 85 men from a non-sprayed region in Vietnam. Then levels of PSA, dioxins, and steroid hormones were analyzed. Levels of most dioxins, furans, and non-ortho polychlorinated biphenyls were higher in the hotspot than those in the non-sprayed region. Levels of testosterone, dehydroepiandrosterone, and estradiol differed significantly between the hotspot and the non-sprayed region, but there were no correlations between levels of PSA and steroid hormones and dioxins in either of the two regions. Our findings suggest that PSA levels in Vietnamese men are not associated with levels of dioxin or steroid hormones in these two regions.
authors.affiliation: Department of Public Health, School of Medicine, Jiaxing University, Jiaxing, China.|Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
authors.forename: Xian Liang
authors.initials: XL
authors.lastname: Sun
authors.affiliation: Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan. kido@mhs.mp.kanazawa-u.ac.jp.|Institute of Medical, Pharmaceutical, and Health Sciences, Faculty of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa, Japan, 920-0942. kido@mhs.mp.kanazawa-u.ac.jp.
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Kido
authors.affiliation: Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Seijiro
authors.initials: S
authors.lastname: Honma
authors.affiliation: Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Okamoto
authors.affiliation: Faculty of Pharmacy, Lac Hong University, Bien Hoa, Vietnam.
authors.forename: Ho Dung
authors.initials: HD
authors.lastname: Manh
authors.affiliation: Department of Public Health, Kanazawa Medical University, Kanazawa, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Maruzeni
authors.affiliation: Department of Public Health, Kanazawa Medical University, Kanazawa, Japan.
authors.forename: Muneko
authors.initials: M
authors.lastname: Nishijo
authors.affiliation: Department of Public Health, Kanazawa Medical University, Kanazawa, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nakagawa
authors.affiliation: Center for Advanced Science and Innovation, Osaka University, Osaka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakano
authors.affiliation: Department of Urology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Osaka, Japan.
authors.forename: Eitetsu
authors.initials: E
authors.lastname: Koh
authors.affiliation: Shimadzu Techno-Research, Inc., Kyoto, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Takasuga
authors.affiliation: 10-80 Division, Hanoi Medical University, Hanoi, Vietnam.
authors.forename: Dang Duc
authors.initials: DD
authors.lastname: Nhu
authors.affiliation: 10-80 Division, Hanoi Medical University, Hanoi, Vietnam.
authors.forename: Nguyen Ngoc
authors.initials: NN
authors.lastname: Hung
authors.affiliation: Environment Administration, Ministry of Natural Resources and Environment, Hanoi, Vietnam.
authors.forename: Le Ke
authors.initials: le K
authors.lastname: Son
mesh_terms: D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000032:analysis / Q000633:toxicity*; D015084:2,4-Dichlorophenoxyacetic Acid / Q000032:analysis / Q000633:toxicity*; D000368:Aged; D000075182:Agent Orange; D001572:Benzofurans; D004147:Dioxins; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D005663:Furans / Q000032:analysis; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000032:analysis; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms; D013256:Steroids; D013739:Testosterone; D014744:Vietnam
chemical_list: D001572:Benzofurans; D004147:Dioxins; D004785:Environmental Pollutants; D005663:Furans; D012739:Gonadal Steroid Hormones; D000072317:Polychlorinated Dibenzodioxins; D013256:Steroids; D015084:2,4-Dichlorophenoxyacetic Acid; D000075182:Agent Orange; D013739:Testosterone; D015085:2,4,5-Trichlorophenoxyacetic Acid; D011078:Polychlorinated Biphenyls; D017430:Prostate-Specific Antigen
keywords: Polychlorinated biphenyls; Polychlorinated dibenzo-p-dioxins; Polychlorinated dibenzofurans; Prostate-specific antigen; Steroid hormones; Vietnamese men