title: Reversible Posterior Leukoencephalopathy Syndrome Due to Carboplatin and Paclitaxel Therapy.
abstract: BACKGROUND
  Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinicoradiologic syndrome characterized by headache, decreased alertness, seizures, visual abnormalities, and white matter changes indicative of cerebral edema. Although the pathogenesis remains poorly understood, several etiological causes have been described. RPLS is a common complication of chemotherapeutics because of its toxic effect on the central nervous system. This syndrome is frequently associated with seizures but rarely seen with status epilepticus and periodic lateralized epileptiform discharges (PLEDs).
  
  
  METHODS
  We present a case with metastatic lung cancer that developed RPLS after carboplatin and paclitaxel therapy. Our case was admitted to the hospital with status epilepticus and her electroencephalography showed PLEDs.
  
  
  CONCLUSIONS
  It is important to closely monitor blood pressure and electrolyte levels in patients who take chemotherapeutic agents, especially when there is no previous history of hypertension. It should be kept in mind that RPLS is a causative factor of status epilepticus and PLEDs.
authors.affiliation: Department of Neurology, Bayındır Hospital İçerenköy, İstanbul, Turkey.
authors.forename: Melek
authors.initials: M
authors.lastname: Kandemir
authors.affiliation: Department of Internal Medicine, Bayındır Hospital İçerenköy, İstanbul, Turkey.
authors.forename: Belgin
authors.initials: B
authors.lastname: Küçükkaya
authors.affiliation: Department of Radiology, Bayındır Hospital İçerenköy, İstanbul, Turkey.
authors.forename: Muzaffer Savaş
authors.initials: MS
authors.lastname: Tepe
authors.affiliation: Department of Neurology, Bayındır Hospital İçerenköy, İstanbul, Turkey.
authors.forename: Zehra Betül
authors.initials: ZB
authors.lastname: Yalçıner
authors.affiliation: Department of Oncology, Italian Hospital, İstanbul, Turkey.
authors.forename: Nedret Taflan
authors.initials: NT
authors.lastname: Salepçi
keywords: Carboplatin; drug therapy; paclitaxel; posterior leukoencephalopathy syndrome; status epilepticus