title: Synergistic gold and enamine catalysis: intermolecular α-alkylation of aldehydes with allenamides.
abstract: Aldehydes can be α-alkylated with allenamides by the combined action of an organocatalyst and a gold complex. The reaction requires the simultaneous generation of an enamine and a gold-activated allenamide. Importantly, by using a chiral amine as organocatalyst it is possible to obtain aldehyde products featuring all-carbon quaternary stereocenter at their α-position, with moderate to good levels of enantioselectivity.
authors.affiliation: Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS) and Departamento de Química Orgánica, Universidad de Santiago de Compostela, C/Jenaro de la Fuente, s/n, 15782, Santiago de Compostela, Spain. joseluis.mascarenas@usc.es fernando.lopez@csic.es.
authors.forename: Jaime
authors.initials: J
authors.lastname: Fernández-Casado
authors.affiliation: Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS) and Departamento de Química Orgánica, Universidad de Santiago de Compostela, C/Jenaro de la Fuente, s/n, 15782, Santiago de Compostela, Spain. joseluis.mascarenas@usc.es fernando.lopez@csic.es.
authors.forename: Ronald
authors.initials: R
authors.lastname: Nelson
authors.affiliation: Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS) and Departamento de Química Orgánica, Universidad de Santiago de Compostela, C/Jenaro de la Fuente, s/n, 15782, Santiago de Compostela, Spain. joseluis.mascarenas@usc.es fernando.lopez@csic.es.
authors.forename: José L
authors.initials: JL
authors.lastname: Mascareñas
authors.affiliation: Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS) and Departamento de Química Orgánica, Universidad de Santiago de Compostela, C/Jenaro de la Fuente, s/n, 15782, Santiago de Compostela, Spain. joseluis.mascarenas@usc.es fernando.lopez@csic.es and Instituto de Química Orgánica General (CSIC), Juan de la Cierva, 3, 28006, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: López