title: Hyaluronate nanoparticles included in polymer films for the prolonged release of vitamin E for the management of skin wounds.
abstract: Lecithin and hyaluronic acid were used for the preparation of polysaccharide decorated nanoparticles loaded with vitamin E using the cationic lipid dioctadecyldimethylammonium bromide (DODMA). Nanoparticles showed mean particle size in the range 130-350 nm and narrow size distribution. Vitamin E encapsulation efficiency was higher than 99%. These nanoparticles were incorporated in polymeric films containing Aloe vera extract, hyaluronic acid, sodium alginate, polyethyleneoxide (PEO) and polyvinylalcohol (PVA) as an innovative treatment in skin wounds. Films were thin, flexible, resistant and suitable for application on burn wounds. Additionally, in vitro occlusion study highlighted the dependence of the occlusive effect on the presence of nanoparticles. The results obtained show that the bioadhesive films containing vitamin E acetate and Aloe vera could be an innovative therapeutic system for the treatment of skin wounds, such as burns. The controlled release of the vitamin along with a reduction in water loss through damaged skin provided by the nanoparticle-loaded polymer film are considered important features for an improvement in wound healing and skin regeneration.
authors.affiliation: Faculty the Pharmacy, University Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Gabriela Garrastazu
authors.initials: GG
authors.lastname: Pereira
authors.affiliation: Faculty the Pharmacy, University Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Cassia Britto
authors.initials: CB
authors.lastname: Detoni
authors.affiliation: Biopharmanet-TEC, Interdepartmental Centre for Innovation in Health Products, University of Parma, Italy; Department of Pharmacy, University of Parma, Italy.
authors.forename: Anna Giulia
authors.initials: AG
authors.lastname: Balducci
authors.affiliation: Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Rondelli
authors.affiliation: Department of Pharmacy, University of Parma, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Colombo
authors.affiliation: Faculty the Pharmacy, University Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Silvia Stanisçuaski
authors.initials: SS
authors.lastname: Guterres
authors.affiliation: Biopharmanet-TEC, Interdepartmental Centre for Innovation in Health Products, University of Parma, Italy; Department of Pharmacy, University of Parma, Italy; Graduate School of Health - Pharmacy, University of Technology Sydney, Australia. Electronic address: fabio.sonvico@uts.edu.au.
authors.forename: Fabio
authors.initials: F
authors.lastname: Sonvico
mesh_terms: D000464:Alginates / Q000737:chemistry; D000504:Aloe; D000975:Antioxidants / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry*; D054709:Lecithins / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012867:Skin / Q000473:pathology; D014810:Vitamin E / Q000737:chemistry*; D014815:Vitamins / Q000737:chemistry; D014945:Wound Healing
chemical_list: D000464:Alginates; D000975:Antioxidants; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D054709:Lecithins; D010936:Plant Extracts; D000644:Quaternary Ammonium Compounds; D014815:Vitamins; D014810:Vitamin E; C015831:dimethyldioctadecylammonium; D011092:Polyethylene Glycols; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol; D006820:Hyaluronic Acid
keywords: Burns; Hyaluronate nanoparticles; Local delivery; Polymer film; Vitamin E; Wound healing