title: Cascade Pd(II)-catalyzed Wacker lactonization-Heck reaction: rapid assembly of spiranoid lactones.
abstract: An unprecedented Pd-catalyzed cascade Wacker-Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4-exo trig Heck-type cyclization is demonstrated.
authors.affiliation: The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. dmitryt@ekmd.huji.ac.il.
authors.forename: Ghassan
authors.initials: G
authors.lastname: Albarghouti
authors.affiliation: The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. dmitryt@ekmd.huji.ac.il.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Kotikalapudi
authors.affiliation: The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. dmitryt@ekmd.huji.ac.il.
authors.forename: David
authors.initials: D
authors.lastname: Lankri
authors.affiliation: The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. dmitryt@ekmd.huji.ac.il.
authors.forename: Viviana
authors.initials: V
authors.lastname: Valerio
authors.affiliation: The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. dmitryt@ekmd.huji.ac.il.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Tsvelikhovsky