title: Target-organ damage and incident hypertension: the Korean genome and epidemiology study.
abstract: OBJECTIVE
  Hypertension is associated with cardiovascular organ damage. However, data are scanty on whether individual forms or combinations of subclinical target organ damage (TOD) increase the risk of incident hypertension in nonhypertensive study participants.
  
  
  METHODS
  A total of 1785 nonhypertensive participants from the fourth biennial examination (2007-2008) of the Korean Genome and Epidemiology Study were followed-up for four years. Echocardiographic left ventricular (LV) hypertrophy, LV diastolic dysfunction, increased carotid intima-media thickness (cIMT), and brachial-ankle pulse wave velocity (baPWV) were defined according to the current guidelines.
  
  
  RESULTS
  During 4-year follow-up, 19.9% of participants developed hypertension. In multivariate Cox proportional hazards models, the adjusted hazard ratios for developing hypertension were 1.39, 1.66, 1.48, and 0.78 for higher values of the LV mass index, cIMT, baPWV, and tissue Doppler e' velocity, respectively (all P < 0.01). The hazard ratios for LV hypertrophy, LV diastolic dysfunction, cIMT >75th percentile, and baPWV ≥ 1400 cm/s were 1.61, 1.30, 1.86, and 2.07, respectively (all P < 0.05). Compared with participants without any TOD, those with combinations of TOD types had significantly greater risk for developing hypertension (hazard ratio = 2.12 and 3.98 for 1-2 and 3-4 TOD sites, respectively, all P < 0.001).
  
  
  CONCLUSIONS
  In the nonhypertensive population, each subclinical form of TOD independently predicts incident hypertension. In addition, the combinations of various forms of TOD are associated with stepwise increases in the risk for developing hypertension. The results suggest that asymptomatic TOD does not always exist in an intermediate stage in the cardiovascular continuum.
authors.affiliation: aDivision of Cardiology, Department of Medicine, Korea University Ansan Hospital, Korea University College of Medicine bCardiovascular Center, Korea University Guro Hospital, Korea University College of Medicine cDivision of Cardiology, Department of Medicine, Seoul National University Bundang Hospital dDepartment of Foods and Nutrition, College of Natural Sciences, Kookmin University eDivision of Cardiology, Department of Medicine, Kangbuk Samsung Hospital fDivision of Endocrinology, Department of Medicine, Hallym University Kangdong Sacred Heart Hospital gInstitute of Human Genomic Study, Korea University Ansan Hospital, Korea University College of Medicine, South Korea.
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Kim
authors.forename: Jin-Seok
authors.initials: JS
authors.lastname: Kim
authors.forename: Sang Yup
authors.initials: SY
authors.lastname: Lim
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Jung
authors.forename: Hong Euy
authors.initials: HE
authors.lastname: Lim
authors.forename: Eung-Ju
authors.initials: EJ
authors.lastname: Kim
authors.forename: Goo-Yeong
authors.initials: GY
authors.lastname: Cho
authors.forename: Inkyung
authors.initials: I
authors.lastname: Baik
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Sung
authors.forename: Juri
authors.initials: J
authors.lastname: Park
authors.forename: Seung Ku
authors.initials: SK
authors.lastname: Lee
authors.forename: Chol
authors.initials: C
authors.lastname: Shin
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D059168:Carotid Intima-Media Thickness; D015331:Cohort Studies; D003971:Diastole; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D056910:Republic of Korea / Q000453:epidemiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000453:epidemiology*