title: Significant Beneficial Association of High Dietary Selenium Intake with Reduced Body Fat in the CODING Study.
abstract: Selenium (Se) is a trace element which plays an important role in adipocyte hypertrophy and adipogenesis. Some studies suggest that variations in serum Se may be associated with obesity. However, there are few studies examining the relationship between dietary Se and obesity, and findings are inconsistent. We aimed to investigate the association between dietary Se intake and a panel of obesity measurements with systematic control of major confounding factors. A total of 3214 subjects participated in the study. Dietary Se intake was determined from the Willett food frequency questionnaire. Body composition was measured using dual-energy X-ray absorptiometry. Obese men and women had the lowest dietary Se intake, being 24% to 31% lower than corresponding normal weight men and women, classified by both BMI and body fat percentage. Moreover, subjects with the highest dietary Se intake had the lowest BMI, waist circumference, and trunk, android, gynoid and total body fat percentages, with a clear dose-dependent inverse relationship observed in both gender groups. Furthermore, significant negative associations discovered between dietary Se intake and obesity measurements were independent of age, total dietary calorie intake, physical activity, smoking, alcohol, medication, and menopausal status. Dietary Se intake alone may account for 9%-27% of the observed variations in body fat percentage. The findings from this study strongly suggest that high dietary Se intake is associated with a beneficial body composition profile.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning, China. 271975039@qq.com.
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Discipline of Medicine, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada. xx526916212@126.com.|College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, China. xx526916212@126.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.affiliation: The Discipline of Medicine, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada. pedram.pardis@gmail.com.
authors.forename: Pardis
authors.initials: P
authors.lastname: Pedram
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, AB T6G 2G3, Canada. mshahidi@ualberta.ca.
authors.forename: Mariam
authors.initials: M
authors.lastname: Shahidi
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning, China. dujianling63@163.com.
authors.forename: Jianling
authors.initials: J
authors.lastname: Du
authors.affiliation: Division of Community Health &amp; Humanities, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada. yanqing.yi@med.mun.ca.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Yi
authors.affiliation: The Discipline of Medicine, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada. drgulliver@newlabresearch.com.
authors.forename: Wayne
authors.initials: W
authors.lastname: Gulliver
authors.affiliation: The Discipline of Medicine, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada. hongwei8888@hotmail.com.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: The Discipline of Medicine, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada. gsun@mun.ca.
authors.forename: Guang
authors.initials: G
authors.lastname: Sun
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000328:Adult; D000886:Anthropometry; D001823:Body Composition; D015992:Body Mass Index; D004034:Diet Surveys; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009523:Newfoundland and Labrador; D009765:Obesity / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D012643:Selenium / Q000008:administration & dosage*; D014131:Trace Elements / Q000008:administration & dosage*; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D014131:Trace Elements; D012643:Selenium
keywords: adult population; body composition; confounding factors; dietary selenium intake