title: Iris autofluorescence in Fuchs' heterochromic uveitis.
abstract: To explore the characteristic autofluorescence patterns of iris depigmentation in eyes diagnosed with Fuchs' heterochromic uveitis (FHU).
  
  
  
  Near-infrared autofluorescence images and colour images of iris were taken in 21 eyes of 21 patients with FHU, 30 eyes of 15 normal subjects, 30 eyes of 15 normal age-related iris atrophy and 33 eyes of 20 patients with uveitis other than FHU. The confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2, HRA2) was used for melanin-related autofluorescence imaging. The indocyanine green angiography mode of HRA2 was applied for near-infrared laser imaging, and the wavelength of the excitation laser was 795 nm. Iris colour images were also taken with the slit lamp.
  
  
  
  In normal iris, moderately intense autofluorescence was noted for the pigment ruff at the pupillary border, the crests in the pupillary zone and the collarette; and there was mild autofluorescence in the ciliary zone. In eyes with age-related iris atrophy and uveitis, much less autofluorescence was seen than the healthy normal irides. In eyes with FHU, there was moderate but discontinuous autofluorescence in the pigment ruff, a petaloid pattern of autofluorescence in the pupillary zone, moderate autofluorescence in the collarette and reticular pattern of autofluorescence in the ciliary zone.
  
  
  
  Characteristic autofluorescence patterns appeared in eyes diagnosed with FHU. Near-infrared autofluorescence is a promising objective technique to document the iris changes in FHU.
authors.affiliation: Retinal Department, Shanxi Eye Hospital, Taiyuan, Shanxi Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Retinal Department, Shanxi Eye Hospital, Taiyuan, Shanxi Province, China.
authors.forename: Yading
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Retinal Department, Shanxi Eye Hospital, Taiyuan, Shanxi Province, China.
authors.forename: Suhua
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Retinal Department, Shanxi Eye Hospital, Taiyuan, Shanxi Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xie
authors.affiliation: Retinal Department, Shanxi Eye Hospital, Taiyuan, Shanxi Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chang
authors.affiliation: Retinal Department, Shanxi Eye Hospital, Taiyuan, Shanxi Province, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Hou
authors.affiliation: Retinal Department, Shanxi Eye Hospital, Taiyuan, Shanxi Province, China.
authors.forename: Gaiyun
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Koch
authors.affiliation: Retinal Department, Shanxi Eye Hospital, Taiyuan, Shanxi Province, China Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015863:Iridocyclitis / Q000175:diagnosis*; D007498:Iris / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods*; D061848:Optical Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D055815:Young Adult
keywords: Diagnostic tests/Investigation; Imaging; Iris