title: FINEMAP: efficient variable selection using summary data from genome-wide association studies.
abstract: The goal of fine-mapping in genomic regions associated with complex diseases and traits is to identify causal variants that point to molecular mechanisms behind the associations. Recent fine-mapping methods using summary data from genome-wide association studies rely on exhaustive search through all possible causal configurations, which is computationally expensive.
  
  
  
  We introduce FINEMAP, a software package to efficiently explore a set of the most important causal configurations of the region via a shotgun stochastic search algorithm. We show that FINEMAP produces accurate results in a fraction of processing time of existing approaches and is therefore a promising tool for analyzing growing amounts of data produced in genome-wide association studies and emerging sequencing projects.
  
  
  
  FINEMAP v1.0 is freely available for Mac OS X and Linux at http://www.christianbenner.com
  
  
  
  : christian.benner@helsinki.fi or matti.pirinen@helsinki.fi.
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Public Health, University of Helsinki, Helsinki, Finland.
authors.forename: Christian
authors.initials: C
authors.lastname: Benner
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
authors.forename: Chris C A
authors.initials: CC
authors.lastname: Spencer
authors.affiliation: National Institute for Health and Welfare (THL), Helsinki, Finland and.
authors.forename: Aki S
authors.initials: AS
authors.lastname: Havulinna
authors.affiliation: National Institute for Health and Welfare (THL), Helsinki, Finland and.
authors.forename: Veikko
authors.initials: V
authors.lastname: Salomaa
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Public Health, University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
authors.forename: Samuli
authors.initials: S
authors.lastname: Ripatti
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Pirinen
mesh_terms: D000465:Algorithms; D016678:Genome; D055106:Genome-Wide Association Study; D023281:Genomics; D020641:Polymorphism, Single Nucleotide; D012984:Software