title: Propofol sedation versus no sedation in detection of pharyngeal and upper gastrointestinal superficial squamous cell carcinoma using endoscopic narrow band imaging: a multicenter prospective trial.
abstract: Intravenous propofol can provide a superior quality of sedation compared to standard sedation for upper gastrointestinal endoscopy. However, the utility of propofol sedation for the endoscopic early detection of superficial pharyngeal and esophageal squamous cell carcinoma has not been investigated. In a multicenter, prospective trial, 255 patients with esophageal squamous cell carcinomas (ESCCs) were assigned to receive propofol sedation or no sedation according to their own willingness. The primary aim was to compare the detection rates of superficial cancer in the pharyngeal region and the esophagus between two groups. The secondary aim was to evaluate factors associated with technical adequacy. The detection rate was higher in the propofol sedation vs. no sedation group for H&N region (6.06% vs. 2.40%), but not significantly (P=0.22). However, the small lesion (less than 10 mm in diameter) detection rate was higher in sedation vs. no sedation group for H&N region (88.89% vs. 33.33%; P=0.048). The median time for pharyngeal observation in the sedation group was faster than in the no sedation group (20.6 s vs. 44.3 s; P<0.001). Ninety-five percent of H&N region evaluations were totally complete in sedation compared with sixty percent in the no sedation group (P<0.001). The overall p value indicated that only smoking habit was associated with incomplete pharyngeal observation (P<0.05), and it was more difficult to accomplish a complete pharyngeal observation in patients who smoked more than 10 packs per day. Intravenous propofol sedation compared to no intravenous sedation during conventional upper gastrointestinal endoscopy can facilitate a more complete pharyngeal examination and increase the detection rate of superficial H&N squamous cell carcinoma in high risk patients.
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital Beijing 100700, China.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of VIP, Beijing Military General Hospital Beijing 100700, China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital Beijing 100700, China.
authors.forename: Kuangi
authors.initials: K
authors.lastname: Fu
authors.affiliation: Department of Science, Tianjin University of Commerce Tianjin 300134, China.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University Chongqing 400038, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yu
authors.affiliation: Institute for Translational Medicine, College of Medicine, Qingdao University Qingdao 266021, China.
authors.forename: Jianxun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital Beijing 100700, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Jin
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital Beijing 100700, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital Beijing 100700, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital Beijing 100700, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Gastroenterology, 285 Hospital of PLA Handan, Hebei 056001, China.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, 285 Hospital of PLA Handan, Hebei 056001, China.
authors.forename: Fayun
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital Beijing 100700, China.
authors.forename: Jianqiu
authors.initials: J
authors.lastname: Sheng
keywords: Esophageal squamous cell carcinoma; head and neck cancer; high-risk patients; propofol sedation; superficial cancer