title: Evaluation of the Nano-TiO2 as a Novel Deswelling Material.
abstract: Nano-TiO2 is widely applied in the automobile exhaust hose reels as a catalyst to reduce oxynitride emissions, including nitric oxide (NO). In the biomedicine field, NO plays an important role in vasodilation and edema formation in human bodies. However, the deswelling activity of nano-TiO2 has not been reported. Here, we demonstrated that nano-TiO2 can significantly degrade the production of NO in LPS-induced RAW264.7 mouse macrophages. Further study indicated that nano-TiO2 exhibited an effect on vascular permeability inhibition, and prevented carrageenan-induced footpad edema. Therefore, we prepared a nano-TiO2 ointment and observed similar deswelling effects. In conclusion, nano-TiO2 might act as a novel deswelling agent related with its degradation of NO, which will aid in our ability to design effective interventions for edema involved diseases.
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China. famous@bjmu.edu.cn.|Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China. famous@bjmu.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Chu
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China. hou.yuelong@163.com.|Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China. hou.yuelong@163.com.
authors.forename: Yue-Long
authors.initials: YL
authors.lastname: Hou
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China. xulanyn@163.com.|Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China. xulanyn@163.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Xu
authors.affiliation: Pharmacy Department, Liao Ning University of Traditional Chinese Medicine, Shenyang 116600, Liao Ning, China. chuzhengyun@163.com.
authors.forename: Zheng-Yun
authors.initials: ZY
authors.lastname: Chu
authors.affiliation: Pharmacy Department, Liao Ning University of Traditional Chinese Medicine, Shenyang 116600, Liao Ning, China. mbzhang@126.com.
authors.forename: Ming-Bo
authors.initials: MB
authors.lastname: Zhang
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China. yff1118@163.com.|Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China. yff1118@163.com.
authors.forename: Yue-Dan
authors.initials: YD
authors.lastname: Wang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D002384:Catalysis; D002460:Cell Line; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006614:Hindlimb; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D049329:Nanostructures / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014025:Titanium / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C009495:titanium dioxide; D009569:Nitric Oxide; D002351:Carrageenan; D014025:Titanium
keywords: deswelling activity; nano-TiO2; nano-TiO2 ointment; nitric oxide; vascular permeability