title: Identification of a Neuronal Receptor Controlling Anaphylaxis.
abstract: Allergic reactions can in severe cases induce a state of circulatory shock referred to as anaphylaxis. Histamine, the primary mediator of this condition, is released from immune cells, and, therefore, anaphylaxis has so far been considered an immune system disorder. However, we here show that the glutamatergic receptor mGluR7, expressed on a subpopulation of both peripheral and spinal cord neurons, controls histamine-induced communication through calcium-dependent autoinhibition with implications for anaphylaxis. Genetic ablation of mGluR7, and thus altered regulation of histamine-sensing neurons, caused an anaphylaxis-like state in mGluR7(-/-) mice, which could be reversed by antagonizing signaling between neurons and mast cells but not by antagonizing a central itch pathway. Our findings demonstrate the vital role of nervous system control by mGluR7 in anaphylaxis and open up possibilities for preventive strategies for this life-threatening condition.
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Rogoz
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
authors.forename: Bejan
authors.initials: B
authors.lastname: Aresh
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
authors.forename: Fabio Batista
authors.initials: FB
authors.lastname: Freitag
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
authors.forename: Hanna
authors.initials: H
authors.lastname: Pettersson
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
authors.forename: Elín Ingibjörg
authors.initials: EI
authors.lastname: Magnúsdóttir
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
authors.forename: Linn
authors.initials: L
authors.lastname: Larsson Ingwall
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
authors.forename: Helena
authors.initials: H
authors.lastname: Haddadi Andersen
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
authors.forename: Marina Christina Mikaela
authors.initials: MC
authors.lastname: Franck
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
authors.forename: Chetan
authors.initials: C
authors.lastname: Nagaraja
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
authors.forename: Klas
authors.initials: K
authors.lastname: Kullander
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden. Electronic address: malin.lagerstrom@neuro.uu.se.
authors.forename: Malin Charlotta
authors.initials: MC
authors.lastname: Lagerström
mesh_terms: D000707:Anaphylaxis / Q000235:genetics*; D000818:Animals; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000378:metabolism*