title: Rapid and Early Diagnosis of Posttransplant Lymphoproliferative Disease Using Cross-Sectional Nuclear Medicine Imaging and Laparoscopic Lymph Node Biopsy: A Report of 2 Cases.
abstract: Posttransplant lymphoproliferative disease is a complication of organ transplant with a myriad clinical and anatomic manifestations, thus making diagnosis difficult without histologic confirmation. In cases of lymphadenopathy confined to the abdomen, the diagnosis can be delayed because of late presentation and difficulty obtaining a tissue for histologic analyses. We describe the use of cross-sectional nuclear medicine imaging to locate enlarged abdominal lymph nodes; this facilitated minimally invasive laparoscopic lymph node excision biopsy to rapidly diagnose 2 cases of post-transplant lymphoproliferative disease. Prompt diagnosis has enabled early effective treatment, resulting in good patient outcomes.
authors.affiliation: From the Royal Free London NHS Foundation Trust Renal Transplant Department, United Kingdom.
authors.forename: Sarah
authors.initials: S
authors.lastname: Lewis
authors.forename: Mark
authors.initials: M
authors.lastname: Harber
authors.forename: Bimbi
authors.initials: B
authors.lastname: Fernando
authors.forename: Neal
authors.initials: N
authors.lastname: Banga
mesh_terms: D000328:Adult; D001706:Biopsy; D004359:Drug Therapy, Combination; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D010535:Laparoscopy; D008197:Lymph Node Excision / Q000379:methods*; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents