title: Burning mouth syndrome.
abstract: BACKGROUND
  Burning mouth syndrome mainly affects women, particularly after the menopause, when its prevalence may be 18% to 33%.
  
  
  METHODS
  We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of selected treatments for burning mouth syndrome? We searched: Medline, Embase, The Cochrane Library, and other important databases up to January 2015 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview).
  
  
  RESULTS
  At this update, searching of electronic databases retrieved 70 studies. After deduplication and removal of conference abstracts, 45 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 25 studies and the further review of 20 full publications. Of the 20 full articles evaluated, one systematic review and nine RCTs were added at this update. We performed a GRADE evaluation for five PICO combinations.
  
  
  CONCLUSIONS
  In this systematic overview, we categorised the efficacy for six interventions based on information about the effectiveness and safety of alphalipoic acid, benzodiazepines, benzydamine hydrochloride, cognitive behavioural therapy (CBT), selective serotonin re-uptake inhibitors (SSRIs), and tricyclic antidepressants.
authors.affiliation: Division of Diagnostic, Surgical and Medical Sciences, Eastman Dental Hospital, UCLH NHS Foundation, London, UK.
authors.forename: Joanna
authors.initials: J
authors.lastname: Zakrzewska
authors.forename: John A G
authors.initials: JA
authors.lastname: Buchanan
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001569:Benzodiazepines / Q000627:therapeutic use; D001591:Benzydamine / Q000627:therapeutic use; D002054:Burning Mouth Syndrome / Q000628:therapy*; D015928:Cognitive Behavioral Therapy; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000929:Antidepressive Agents, Tricyclic; D001569:Benzodiazepines; D001591:Benzydamine; D017367:Selective Serotonin Reuptake Inhibitors