title: The role of complement system in adipose tissue-related inflammation.
abstract: As the common factor linking adipose tissue to the metabolic context of obesity, insulin resistance and atherosclerosis are associated with a low-grade chronic inflammatory status, to which the complement system is an important contributor. Adipose tissue synthesizes complement proteins and is a target of complement activation. C3a-desArg/acylation-stimulating protein stimulates lipogenesis and affects lipid metabolism. The C3a receptor and C5aR are involved in the development of adipocytes' insulin resistance through macrophage infiltration and the activation of adipose tissue. The terminal complement pathway has been found to be instrumental in promoting hyperglycemia-associated tissue damage, which is characteristic of the major vascular complications of diabetes mellitus and diabetic ketoacidosis. As a mediator of the effects of the terminal complement complex C5b-9, RGC-32 has an impact on energy expenditure as well as lipid and glucose metabolic homeostasis. All of this evidence, taken together, indicates an important role for complement activation in metabolic diseases.
authors.affiliation: Department of Neurology, University of Maryland, School of Medicine, 655 W Baltimore St, BRB 12-033, Baltimore, MD, 21201, USA.|Department of Internal Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Sonia I
authors.initials: SI
authors.lastname: Vlaicu
authors.affiliation: Department of Neurology, University of Maryland, School of Medicine, 655 W Baltimore St, BRB 12-033, Baltimore, MD, 21201, USA.|Research Service, Veterans Administration Maryland Health Care System, Baltimore, MD, USA.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Tatomir
authors.affiliation: Department of Neurology, University of Maryland, School of Medicine, 655 W Baltimore St, BRB 12-033, Baltimore, MD, 21201, USA.
authors.forename: Dallas
authors.initials: D
authors.lastname: Boodhoo
authors.affiliation: Department of Pharmacology, Toxicology and Clinical Pharmacology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Stefan
authors.initials: S
authors.lastname: Vesa
authors.affiliation: Department of Internal Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Petru A
authors.initials: PA
authors.lastname: Mircea
authors.affiliation: Department of Neurology, University of Maryland, School of Medicine, 655 W Baltimore St, BRB 12-033, Baltimore, MD, 21201, USA. hrus@umaryland.edu.|Research Service, Veterans Administration Maryland Health Care System, Baltimore, MD, USA. hrus@umaryland.edu.|Veterans Administration Multiple Sclerosis Center of Excellence, Baltimore, MD, USA. hrus@umaryland.edu.
authors.forename: Horea
authors.initials: H
authors.lastname: Rus
mesh_terms: D000273:Adipose Tissue / Q000276:immunology*; D000818:Animals; D003167:Complement Activation; D003165:Complement System Proteins / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007333:Insulin Resistance; D050356:Lipid Metabolism; D009765:Obesity / Q000276:immunology*
chemical_list: D003165:Complement System Proteins
keywords: Adipose tissue; C5b-9; Complement activation; Diabetes mellitus; Metabolic syndrome; RGC-32