title: Intermolecular Peptide Cross-Linking by Using Diaminodicarboxylic Acids.
abstract: Synthetic methods aimed at preparing peptides cross-linked by diaminodiacids remain an important chemical challenge. These cross-links are known to play a crucial role on the activity, structural stability, and folding of the host peptides and proteins. Recent developments in the syntheses of such systems have led to intriguing advances in the understanding of intermolecular side-chain cross-linking and the role that these structural motifs play in the biochemistry of proteins. Herein we provide an overview of the existing synthetic methodology that has been developed to effect protein cross-linking using diaminodiacids.
authors.affiliation: Institute of Biological Chemistry, Faculty of Chemistry, Währinger Straße 38, 1090, Vienna, Austria.
authors.forename: Meder
authors.initials: M
authors.lastname: Kamalov
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds St., Auckland, 1142, New Zealand.
authors.forename: Harveen
authors.initials: H
authors.lastname: Kaur
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds St., Auckland, 1142, New Zealand. m.brimble@auckland.ac.nz.|School of Biological Sciences, The University of Auckland, 3 Symonds St., Auckland, 1142, New Zealand. m.brimble@auckland.ac.nz.|Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3 Symonds St., Auckland, 1142, New Zealand. m.brimble@auckland.ac.nz.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
mesh_terms: D000595:Amino Acid Sequence; D002264:Carboxylic Acids / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003959:Diamines / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism
chemical_list: D002264:Carboxylic Acids; D003432:Cross-Linking Reagents; D003959:Diamines; D010455:Peptides
keywords: Alzheimer's disease; amino acids; biochemistry; peptide synthesis; proteins