title: Molecular Phenotyping Small (Asian) versus Large (Western) Plaque Psoriasis Shows Common Activation of IL-17 Pathway Genes but Different Regulatory Gene Sets.
abstract: Psoriasis is present in all racial groups, but in varying frequencies and severity. Considering that small plaque psoriasis is specific to the Asian population and severe psoriasis is more predominant in the Western population, we defined Asian small and intermediate plaque psoriasis as psoriasis subtypes and compared their molecular signatures with the classic subtype of Western large plaque psoriasis. Two different characteristics of psoriatic spreading-vertical growth and radial expansion-were contrasted between subtypes, and genomic data were correlated to histologic and clinical measurements. Compared with Western large plaque psoriasis, Asian small plaque psoriasis revealed limited psoriasis spreading, but IL-17A and IL-17-regulated proinflammatory cytokines were highly expressed. Paradoxically, IL-17A and IL-17-regulated proinflammatory cytokines were lower in Western large plaque psoriasis, whereas T cells and dendritic cells in total psoriatic skin area were exponentially increased. Negative immune regulators, such as CD69 and FAS, were decreased in both Western large plaque psoriasis and psoriasis with accompanying arthritis or obesity, and their expression was correlated with psoriasis severity index. Based on the disease subtype comparisons, we propose that dysregulation of T-cell expansion enabled by downregulation of immune negative regulators is the main mechanism for development of large plaque psoriasis subtypes.
authors.affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA.
authors.forename: Jaehwan
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Chil-Hwan
authors.initials: CH
authors.lastname: Oh
authors.affiliation: Department of Dermatology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Jiehyun
authors.initials: J
authors.lastname: Jeon
authors.affiliation: Department of Dermatology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Yoosang
authors.initials: Y
authors.lastname: Baek
authors.affiliation: Department of Dermatology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Jaewoo
authors.initials: J
authors.lastname: Ahn
authors.affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA; School of Medicine, Stony Brook University, Stony Brook, New York, USA.
authors.forename: Dong Joo
authors.initials: DJ
authors.lastname: Kim
authors.affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA.
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Lee
authors.affiliation: The Center for Clinical and Translational Science, The Rockefeller University, New York, New York, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Correa da Rosa
authors.affiliation: The Center for Clinical and Translational Science, The Rockefeller University, New York, New York, USA; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Mayte
authors.initials: M
authors.lastname: Suárez-Fariñas
authors.affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA; Division of Dermatology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Lowes
authors.affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA. Electronic address: kruegej@rockefeller.edu.
authors.forename: James G
authors.initials: JG
authors.lastname: Krueger
mesh_terms: D044466:Asian People / Q000235:genetics; D001707:Biopsy, Needle; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D006801:Humans; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D010641:Phenotype; D011565:Psoriasis / Q000208:ethnology* / Q000235:genetics* / Q000473:pathology; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D015398:Signal Transduction; D044465:White People / Q000235:genetics
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17