title: A New Cytotoxic Gymnomitrane Sesquiterpene from Ganoderma lucidum Fruiting Bodies.
abstract: A new gymnomitrane-type sesquiterpenoid, gymnomitrane-3α,5α,9β,15-tetrol (1), was isolated from the fruiting body of Ganoderma lucidum. Its structure was elucidated using spectroscopic methods. This compound significantly inhibited the growth of epidermal growth factor receptor-tyrosine kinase inhibitor EGFR-TKI-resistant human lung cancer A549 and human prostate cancer PC3 cell lines.
authors.forename: Pham Thanh
authors.initials: PT
authors.lastname: Binh
authors.forename: Dimitri
authors.initials: D
authors.lastname: Descoutures
authors.forename: Nguyen Hai
authors.initials: NH
authors.lastname: Dang
authors.forename: Nguyen Phuong Dai
authors.initials: NP
authors.lastname: Nguyen
authors.forename: Nguyen Tien
authors.initials: NT
authors.lastname: Dat
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology*; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D020940:Reishi / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D003603:Cytotoxins; D012717:Sesquiterpenes