title: [Current Status and Prospects on PET Radiopharmaceuticals for Radiotherapy].
abstract: 18F-FDG is a most popular radiopharmaceutical for tumor diagnosis in the world. In addition, 11C-methionine, 18F-FLT and 11C-choline have been used to compensate for drawbacks of 18F-FDG. Now, novel radiopharmaceuticals are required to estimate or predict therapeutic efficacy because we have many strategies to treat tumors. Radiotherapy which damage DNA by producing free radicals is commonly used to treat various types of tumors. Hypoxia is closely associated with resistance to chemo- and/or radiotherapy and is a common feature of solid tumors. Recently, understanding of tumor hypoxia in oncology has led to development of radiopharmaceuticals for hypoxia imaging. This review provides an overview of PET radiopharmaceuticals for hypoxia imaging and 18F-FBPA which is used for boron neutron capture therapy.
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Yoshimoto
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy; D056831:Coordination Complexes; D005462:Fluorine Radioisotopes; D006801:Humans; D000860:Hypoxia / Q000000981:diagnostic imaging; D008920:Misonidazole / Q000031:analogs & derivatives; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D009593:Nitroimidazoles; D009942:Organometallic Compounds; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D013882:Thiosemicarbazones
chemical_list: D001896:Boron Compounds; D056831:Coordination Complexes; D005462:Fluorine Radioisotopes; D009593:Nitroimidazoles; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013882:Thiosemicarbazones; C089548:copper (II) diacetyl-di(N(4)-methylthiosemicarbazone); C031843:fluoromisonidazole; C072915:4-borono-2-fluorophenylalanine; C498052:fluoroazomycin arabinoside; D010649:Phenylalanine; D008920:Misonidazole