title: Serum pregnancy-associated plasma protein A correlates with inflammation and malnutrition in patients treated with maintenance hemodialysis.
abstract: Advanced chronic kidney disease (CKD) leads to complications such as anemia, electrolyte abnormalities, bone and mineral disorder, and malnutrition-inflammation-atherosclerosis (MIA) syndrome, that result in high cardiovascu- lar mortality. One of the biomarkers associated with inflammation and cardiovascular events is pregnancy-associated plasma protein A (PAPP-A). The aim of the study was to measure serum PAPP-A in hemodialyzed CKD patients, and to investigate its correlations with the laboratory markers of the complications. We enrolled 78 consecutive stable adult CKD patients treated with maintenance hemodialysis for median period of 60 months. PAPP-A concentrations were measured with by electrochemiluminescence immunoassay. Average serum PAPP-A in hemodialyzed patients was almost two times higher than the upper reference limit. It positively correlated with N-terminal pro-brain natriuretic peptide (NT-proBNP), serum sodium, and the markers of inflammation and malnutrition. In conclusion, serum PAPP-A seems a useful biomarker associated with cardiovascular dysfunction, inflammatory state and malnutrition in hemodialysis patients.
authors.affiliation: Diagnostic Department of University Hospital in Krakow, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Mazur-Laskowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Bała-Błądzińska
authors.forename: Paulina
authors.initials: P
authors.lastname: Zegartowska
authors.forename: Paulina
authors.initials: P
authors.lastname: Dumnicka
authors.forename: Anna
authors.initials: A
authors.lastname: Ząbek-Adamska
authors.forename: Maria
authors.initials: M
authors.lastname: Kapusta
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Maleszka
authors.forename: Barbara
authors.initials: B
authors.lastname: Maziarz
authors.forename: Marek
authors.initials: M
authors.lastname: Kuźniewski
authors.affiliation: Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland. mbkusnie@cyf-kr.edu.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Kuśnierz-Cabala
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D006435:Renal Dialysis; D018570:Risk Assessment
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D011266:Pregnancy-Associated Plasma Protein-A
keywords: cardiovascular diseases; hemodialysis; malnutrition; pregnancy-associated plasma protein A