title: Baseline estradiol concentration in community-dwelling Japanese American men is not associated with intra-abdominal fat accumulation over 10 years.
abstract: The role of plasma estradiol in the accumulation of intra-abdominal fat (IAF) in men is uncertain. Cross-sectional studies using imaging of IAF have shown either a positive or no association. In contrast, a randomised controlled trial using an aromatase inhibitor to suppress estradiol production found an association between oestrogen deficiency and short-term IAF accumulation. No longitudinal study has been conducted to examine the relationship between plasma estradiol concentration and the change in IAF area measured using direct imaging.
  
  
  
  This is a longitudinal observational study in community-dwelling Japanese-American men (n=215, mean age 52 years, BMI 25.4kg/m2). IAF and subcutaneous fat areas were assessed using computerized tomography (CT) at baseline, 5 and 10 years. Baseline plasma estradiol concentrations were measured using liquid chromatography-tandem mass spectrometry.
  
  
  
  Univariate analysis found no association between baseline estradiol concentration and baseline IAF, or 5- or 10-year changes in IAF area (r=-0.05 for both time points, p=0.45 and p=0.43, respectively). Multivariate linear regression analysis of the change in IAF area by baseline estradiol concentration adjusted for age, baseline IAF area, and weight change found no association with either the 5- or 10-year IAF area change (p=0.52 and p=0.55, respectively).
  
  
  
  Plasma estradiol concentration was not associated with baseline IAF nor with change in IAF area over 5 or 10 years based on serial CT scans in community-dwelling Japanese-American men. These results do not support a role for oestrogen deficiency in IAF accumulation in men.
authors.affiliation: General Medicine and Hospital and Specialty Medicine Services, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States; Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, University of Washington, Seattle, WA, United States; Seattle Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States. Electronic address: bmkocarnik@gmail.com.
authors.forename: Beverly M
authors.initials: BM
authors.lastname: Kocarnik
authors.affiliation: General Medicine and Hospital and Specialty Medicine Services, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States; Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, University of Washington, Seattle, WA, United States; Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, United States.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Boyko
authors.affiliation: Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, United States.
authors.forename: Alvin M
authors.initials: AM
authors.lastname: Matsumoto
authors.affiliation: Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, University of Washington, Seattle, WA, United States.
authors.forename: Wilfred Y
authors.initials: WY
authors.lastname: Fujimoto
authors.affiliation: Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, United States; Department of Preventive Medicine and Environmental Health, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Tomoshige
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: Department of Anthropology, University of Washington, Seattle, WA, United States.
authors.forename: Donna L
authors.initials: DL
authors.lastname: Leonetti
authors.affiliation: Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, University of Washington, Seattle, WA, United States.
authors.forename: Stephanie T
authors.initials: ST
authors.lastname: Page
mesh_terms: D000005:Abdomen; D000328:Adult; D001213:Asian; D004958:Estradiol / Q000097:blood*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D007564:Japan / Q000208:ethnology; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood; D011446:Prospective Studies
chemical_list: D004958:Estradiol
keywords: Adiposity; Estradiol; Intra-abdominal fat; Japanese Americans