title: Annual banned-substance review: analytical approaches in human sports drug testing.
abstract: The aim of improving anti-doping efforts is predicated on several different pillars, including, amongst others, optimized analytical methods. These commonly result from exploiting most recent developments in analytical instrumentation as well as research data on elite athletes' physiology in general, and pharmacology, metabolism, elimination, and downstream effects of prohibited substances and methods of doping, in particular. The need for frequent and adequate adaptations of sports drug testing procedures has been incessant, largely due to the uninterrupted emergence of new chemical entities but also due to the apparent use of established or even obsolete drugs for reasons other than therapeutic means, such as assumed beneficial effects on endurance, strength, and regeneration capacities. Continuing the series of annual banned-substance reviews, literature concerning human sports drug testing published between October 2014 and September 2015 is summarized and reviewed in reference to the content of the 2015 Prohibited List as issued by the World Anti-Doping Agency (WADA), with particular emphasis on analytical approaches and their contribution to enhanced doping controls.
authors.affiliation: Center for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.|European Monitoring Center for Emerging Doping Agents, Cologne/Bonn, Germany.
authors.forename: Mario
authors.initials: M
authors.lastname: Thevis
authors.affiliation: Doping Control Laboratory, United Medix Laboratories, Höyläämötie 14, 00380, Helsinki, Finland.
authors.forename: Tiia
authors.initials: T
authors.lastname: Kuuranne
authors.affiliation: Center for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Walpurgis
authors.affiliation: Center for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
authors.forename: Hans
authors.initials: H
authors.lastname: Geyer
authors.affiliation: Center for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Schänzer
mesh_terms: D000318:Adrenergic beta-Agonists / Q000032:analysis; D000319:Adrenergic beta-Antagonists / Q000032:analysis; D045930:Anabolic Agents / Q000032:analysis; D002186:Cannabinoids / Q000032:analysis; D004232:Diuretics / Q000032:analysis; D004300:Doping in Sports / Q000379:methods; D018628:Gene Dosage; D005938:Glucocorticoids / Q000032:analysis; D006728:Hormones / Q000032:analysis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis; D013058:Mass Spectrometry / Q000379:methods; D058573:Performance-Enhancing Substances / Q000032:analysis; D015813:Substance Abuse Detection / Q000379:methods*
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D045930:Anabolic Agents; D002186:Cannabinoids; D004232:Diuretics; D005938:Glucocorticoids; D006728:Hormones; D036341:Intercellular Signaling Peptides and Proteins; D058573:Performance-Enhancing Substances
keywords: SRT2104; adiporon; gene doping; mass spectrometry; mildronate; sport