title: Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs.
abstract: Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species.
authors.affiliation: Department of Chemistry and Frontier Research Center on Fundamental & Applied Sciences of Matters, National Tsing Hua University, Hsinchu, 30013, Taiwan. jrhwu@mx.nthu.edu.tw.|Department of Chemistry, National Central University, Jhongli City, Taoyuan, 32001, Taiwan. jrhwu@mx.nthu.edu.tw.
authors.forename: Jih Ru
authors.initials: JR
authors.lastname: Hwu
authors.affiliation: Department of Chemistry and Frontier Research Center on Fundamental & Applied Sciences of Matters, National Tsing Hua University, Hsinchu, 30013, Taiwan.|Department of Chemistry, National Central University, Jhongli City, Taoyuan, 32001, Taiwan.
authors.forename: Shwu-Chen
authors.initials: SC
authors.lastname: Tsay
authors.affiliation: Department of Chemistry and Frontier Research Center on Fundamental & Applied Sciences of Matters, National Tsing Hua University, Hsinchu, 30013, Taiwan.
authors.forename: Kao Shu
authors.initials: KS
authors.lastname: Chuang
authors.affiliation: Department of Chemistry and Frontier Research Center on Fundamental & Applied Sciences of Matters, National Tsing Hua University, Hsinchu, 30013, Taiwan.
authors.forename: Mohit
authors.initials: M
authors.lastname: Kapoor
authors.affiliation: Department of Chemistry and Frontier Research Center on Fundamental & Applied Sciences of Matters, National Tsing Hua University, Hsinchu, 30013, Taiwan.
authors.forename: Jia Yu
authors.initials: JY
authors.lastname: Lin
authors.affiliation: National Cheng Kung University, Tainan, 701, Taiwan.
authors.forename: Chen-Sheng
authors.initials: CS
authors.lastname: Yeh
authors.affiliation: National Cheng Kung University, Tainan, 701, Taiwan.
authors.forename: Wu-Chou
authors.initials: WC
authors.lastname: Su
authors.affiliation: National Cheng Kung University, Tainan, 701, Taiwan.
authors.forename: Ping-Ching
authors.initials: PC
authors.lastname: Wu
authors.affiliation: National Cheng Kung University, Tainan, 701, Taiwan.
authors.forename: Tsung-Lin
authors.initials: TL
authors.lastname: Tsai
authors.affiliation: National Cheng Kung University, Tainan, 701, Taiwan.
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Wang
authors.affiliation: National Cheng Kung University, Tainan, 701, Taiwan.
authors.forename: Dar-Bin
authors.initials: DB
authors.lastname: Shieh
keywords: anticancer drugs; biological activity; nanoparticles; platinum; sulindac