title: A very rare case of eyelid metastasis originating from lung adenocarcinoma.
abstract: OBJECTIVE
  To report a very rare eyelid mass confirmed to be a metastasis from lung adenocarcinoma.
  
  
  METHODS
  A 68-year-old man had a two-month history of a large nodule in the right upper eyelid. He was a known case of lung adenocarcinoma since 2 years without a history of systemic metastasis. He underwent further investigations including orbital imaging and biopsy of the lesion.
  
  
  RESULTS
  Biopsy and immunohistochemical evaluations of the eyelid lesion revealed a moderate to poorly differentiated adenocarcinoma, a similar histology to the lung lesion.
  
  
  CONCLUSIONS
  Metastatic involvement of the eyelids is rarely seen; specifically, those associated with lung adenocarcinoma as the source have been reported extremely rare. Eyelid metastases present with various and non-specific clinical features, and therefore biopsy of suspicious or recurrent lesions is highly recommended to rule out such malignant processes.
authors.affiliation: Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Paidarifard St., Pasdaran Ave., Tehran, 16666, Iran. mehditavakolimd@yahoo.com.
authors.forename: Mehdi
authors.identifier: http://orcid.org/0000-0002-4828-2313
authors.initials: M
authors.lastname: Tavakoli
authors.affiliation: Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Paidarifard St., Pasdaran Ave., Tehran, 16666, Iran.
authors.forename: Mahsan
authors.initials: M
authors.lastname: Assadi
authors.affiliation: Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Paidarifard St., Pasdaran Ave., Tehran, 16666, Iran.
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Seifi
authors.affiliation: Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Paidarifard St., Pasdaran Ave., Tehran, 16666, Iran.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Behdad
authors.affiliation: Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Paidarifard St., Pasdaran Ave., Tehran, 16666, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Salour
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D005142:Eyelid Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins
keywords: Adenocarcinoma; Eyelid lesion; Eyelid metastasis; Lung carcinoma