title: Analysis of the reliability of surgeons' ability to differentiate between idiopathic and degenerative spinal deformity in adults radiologically. What descriptive parameters help them decide?
abstract: Adult spinal deformity (ASD) may be classified as idiopathic (ID) or degenerative (DD) (or other) based on classifier's perception, the reliability of and factors inherent to which remain unknown. The aim of this study is to evaluate the inter- and intra-observer reliability of surgeons' perception in differentiating ID from DD and to identify the determinants of this differentiation.
  
  
  
  From a multicentric prospective database of ASD, 179 patients were identified with the diagnosis of ID (n = 103) or DD (n = 76); without previous surgery; and a lumbar coronal curve larger than 20°. Standing antero-posterior and lateral X-rays of these patients were sent to five experienced spine surgeons to be identified as DD or ID (or other); followed by a second round after reshuffling. Weighted kappa statistics were used, the strength of agreement for the kappa coefficient was considered as; 0.81-1 = almost perfect, 0.61-0.8 = substantial, 0.41-0.60 = moderate, 0.21-0.40 = fair, 0.01-0.20 = slight, and ≤0 = poor. Patients were then stratified based on the number of agreements on a total of 10 rounds as excellent (10 out of 10), good (more than 7 out of 10) and fair/poor (7 and less). These excellent and good agreements were further compared for additional radiological parameters.
  
  
  
  Agreement levels were moderate to substantial for intra but mostly fair for inter-observer comparisons. For ID patients, there were 42 cases with excellent and 38 with very good agreement whereas for DD, there were no excellent and only 17 cases with very good agreement. Upon comparison of these (ID vs DD for at least very good cases), it was seen that they were different for some coronal parameters such as lumbar Cobb angle (larger in ID, p < 0.001), central sacral vertical line (CSVL) modifier (C more common in ID, p = 0.007) and presence of rotatory subluxation (less common in DD, p = 0.017), but very different for sagittal parameters (lumbar lordosis, sagittal vertical axis, T2 sagittal tilt, pelvic tilt, sacral slope, and global tilt; increased sagittal imbalance in DD, all p ≤ 0.001).
  
  
  
  Surgeons in this study demonstrated reasonable (moderate to substantial) intra-observer agreement, but only fair agreement amongst them. Alarming as it may appear, we should be cautious in interpreting these results based on only radiology and no clinical information. In patients with good agreement, the most consistent radiologic determinant of degenerative ASD appeared to be the presence of sagittal imbalance.
authors.affiliation: Ankara Spine Center, Iran Caddesi, Kavaklidere, Cankaya, 45/2, 06700, Ankara, Turkey.
authors.forename: Umit Ozgur
authors.initials: UO
authors.lastname: Guler
authors.affiliation: Department of Biostatistics, Yildirim Beyazit University, Ankara, Turkey.
authors.forename: Selcen
authors.initials: S
authors.lastname: Yuksel
authors.affiliation: Ankara Spine Center, Iran Caddesi, Kavaklidere, Cankaya, 45/2, 06700, Ankara, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Yakici
authors.affiliation: Spine Unit, Hospital Universitari Vall d' Hebron, Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Domingo-Sabat
authors.affiliation: Spine Unit, Hospital Universitari Vall d' Hebron, Barcelona, Spain.
authors.forename: Ferran
authors.initials: F
authors.lastname: Pellise
authors.affiliation: Spine Unit, Hospital Universitari La Paz, Madrid, Spain.
authors.forename: Francisco J S
authors.initials: FJ
authors.lastname: Pérez-Grueso
authors.affiliation: Spine Unit, Bordeaux University Hospital, Bordeaux, France.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Obeid
authors.affiliation: Acibadem Maslak Hospital, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alanay
authors.affiliation: Schultess Clinic, Zurich, Switzerland.
authors.forename: Frank
authors.initials: F
authors.lastname: Kleinstück
authors.affiliation: Ankara Spine Center, Iran Caddesi, Kavaklidere, Cankaya, 45/2, 06700, Ankara, Turkey. acaroglue@gmail.com.
authors.forename: Emre
authors.initials: E
authors.lastname: Acaroglu
mesh_terms: D005260:Female; D006801:Humans; D007738:Kyphosis / Q000145:classification / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D000072161:Orthopedic Surgeons; D011859:Radiography; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012600:Scoliosis / Q000145:classification / Q000000981:diagnostic imaging*; D013122:Spinal Diseases / Q000145:classification / Q000000981:diagnostic imaging
keywords: Adult; Deformity; Degenerative; Idiopathic; Spine