title: To stop or not? Tamoxifen therapy for secondary prevention of breast cancer in a patient with ocular toxicity.
abstract: We report a case of a patient with treated breast cancer whose dilated fundus examination showed crystalline deposits in the central region of the macula. She was taking tamoxifen for secondary prevention. Optical coherence tomography revealed individual refractile deposits associated with intraretinal cysts in both eyes. Tamoxifen-related retinopathy was suspected. A decision to discontinue treatment with tamoxifen was considered but had to be taken in conjunction with the oncologist.
authors.affiliation: Leeds Centre for Ophthalmology, Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UK.
authors.forename: Tejaswi
authors.initials: T
authors.lastname: Bommireddy
authors.affiliation: Leeds Centre for Ophthalmology, Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UK.
authors.forename: Zia Iqbal
authors.initials: ZI
authors.lastname: Carrim
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000517:prevention & control; D003560:Cysts / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008875:Middle Aged; D012164:Retinal Diseases / Q000139:chemically induced* / Q000473:pathology; D055502:Secondary Prevention; D013629:Tamoxifen / Q000009:adverse effects*; D041623:Tomography, Optical Coherence
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen