title: Identifying high-risk adult AML patients: epigenetic and genetic risk factors and their implications for therapy.
abstract: Acute myeloid leukemia (AML) is a heterogeneous disease at molecular level, in response to therapy and prognosis. The molecular landscape of AML is evolving with new technologies revealing complex panorama of genetic abnormalities where genomic instability and aberrations of epigenetic regulators play a key role in pathogenesis. The characterization of AML diversity has led to development of new personalized therapeutic strategies to improve outcome of the patients.
authors.affiliation: a Department of Biological Hematology , CHU Montpellier , Montpellier , France.|b Institute of Human Genetics, CNRS-UPR1142 , Montpellier F-34396 , France.|c University of Montpellier 1, UFR de Médecine , Montpellier , France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Bret
authors.affiliation: b Institute of Human Genetics, CNRS-UPR1142 , Montpellier F-34396 , France.
authors.forename: Elena
authors.initials: E
authors.lastname: Viziteu
authors.affiliation: a Department of Biological Hematology , CHU Montpellier , Montpellier , France.|b Institute of Human Genetics, CNRS-UPR1142 , Montpellier F-34396 , France.
authors.forename: Alboukadel
authors.initials: A
authors.lastname: Kassambara
authors.affiliation: a Department of Biological Hematology , CHU Montpellier , Montpellier , France.|b Institute of Human Genetics, CNRS-UPR1142 , Montpellier F-34396 , France.|c University of Montpellier 1, UFR de Médecine , Montpellier , France.
authors.forename: Jerome
authors.initials: J
authors.lastname: Moreaux
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics; D020732:Cytogenetic Analysis; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D057890:Epigenomics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D057285:Precision Medicine; D011379:Prognosis; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor
keywords: Acute myeloid Leukemia; Epigenetics; Genetic; Risk factors; targeted treatment