title: Echocardiographic evaluation of the early cardiotoxic effect of hematopoietic stem cell transplantation in patients with hematologic malignancies.
abstract: The purpose was to evaluate the early cardiotoxic effects of the treatment in the course of hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The studies were conducted on 47 patients qualified for the HSCT. Echocardiography was carried out prior to the HSCT and after the HSCT. It was shown that higher age, administration of cyclophosphamide and higher glucose concentrations represented independent risk factors for the worsening of left ventricular diastolic function. Higher cumulative dose of anthracyclines in the previous cytostatic treatment, higher age and administration of cyclophosphamide represented independent risk factors for worsening of left ventricular systolic function. Peri-transplant therapy in the course of HSCT in patients with hematologic malignancies gives the negative effect on the diastolic and systolic left ventricular function, however, previous treatment is of importance, as higher cumulative dose of anthracyclines represents an independent risk factor for the worsening of left ventricular systolic function.
authors.affiliation: a Department of Pathophysiology , Wroclaw Medical University , Wroclaw , Poland ;
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Poręba
authors.affiliation: a Department of Pathophysiology , Wroclaw Medical University , Wroclaw , Poland ;
authors.forename: Paweł
authors.initials: P
authors.lastname: Gać
authors.affiliation: b Department of Hematology , Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University , Wroclaw , Poland ;
authors.forename: Lidia
authors.initials: L
authors.lastname: Usnarska-Zubkiewicz
authors.affiliation: a Department of Pathophysiology , Wroclaw Medical University , Wroclaw , Poland ;
authors.forename: Witold
authors.initials: W
authors.lastname: Pilecki
authors.affiliation: b Department of Hematology , Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University , Wroclaw , Poland ;
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Kuliczkowski
authors.affiliation: c Department of Internal Medicine , Occupational Diseases and Hypertension, Wroclaw Medical University , Wroclaw , Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Mazur
authors.affiliation: a Department of Pathophysiology , Wroclaw Medical University , Wroclaw , Poland ;
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sobieszczańska
authors.affiliation: c Department of Internal Medicine , Occupational Diseases and Hypertension, Wroclaw Medical University , Wroclaw , Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Poręba
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D066126:Cardiotoxicity; D003131:Combined Modality Therapy; D004452:Echocardiography / Q000379:methods; D006331:Heart Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D019337:Hematologic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D015994:Incidence; D019172:Transplantation Conditioning / Q000009:adverse effects; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology; D020257:Ventricular Remodeling
keywords: Cardiotoxicity; cumulative dose of anthracyclines; echocardiography; hematopoietic stem cell transplantation