title: A randomised controlled trial of peri-operative lidocaine infusions for open radical prostatectomy.
abstract: We allocated 76 men scheduled for radical retropubic prostatectomy to peri-operative lidocaine 2% or saline 0.9%: a pre-operative 0.075 ml.kg(-1) intravenous bolus; an intra-operative intravenous infusion at 0.075 ml.kg(-1) .h(-1) ; and 24 hours' postoperative subcutaneous infusion at 0.075 ml.kg(-1) .h(-1) . Lidocaine reduced the postoperative hospital stay by a mean (95% CI) of 1.3 (0.3-2.4) days, p = 0.017, from a mean (SD) of 4.6 (3.2) days with saline. There were no significant differences in pain at rest or on coughing at 24 h. [corrected]. Lidocaine reduced 24-h morphine consumption by a mean (95% CI) of 13.9 (2.2-25.7) mg, p = 0.021, from a mean (SD) of 52.3 (26.9) mg with saline. There were no differences in other outcomes.
authors.affiliation: Anaesthesia, Peri-operative and Pain Medicine, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Weinberg
authors.affiliation: Department of Anaesthesia, Eastern Health, Box Hill, Victoria, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Rachbuch
authors.affiliation: Department of Anaesthesia, Monash Health, Clayton, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Ting
authors.affiliation: Acute Pain Service, Austin Hospital, Heidelberg, Victoria, Australia.|Department of Anaesthesia, Austin Hospital, Heidelberg, Victoria, Australia.
authors.forename: W
authors.initials: W
authors.lastname: Howard
authors.affiliation: Acute Pain Service, Austin Hospital, Heidelberg, Victoria, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Yeomans
authors.affiliation: School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: I
authors.initials: I
authors.lastname: Gordon
authors.affiliation: Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.|Department of Anaesthesia, Austin Hospital, Heidelberg, Victoria, Australia.
authors.forename: L
authors.initials: L
authors.lastname: McNicol
authors.affiliation: Department of Anaesthesia, Austin Hospital, Heidelberg, Victoria, Australia.
authors.forename: K
authors.initials: K
authors.lastname: James
authors.affiliation: Anaesthesia, Peri-operative and Pain Medicine, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Story
authors.affiliation: Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Christophi
mesh_terms: D000779:Anesthetics, Local; D006801:Humans; D007262:Infusions, Intravenous; D007902:Length of Stay / Q000706:statistics & numerical data; D008012:Lidocaine; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D019990:Perioperative Care / Q000379:methods*; D011467:Prostate / Q000601:surgery; D011468:Prostatectomy; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine