title: Analysis on clinical characteristics of intracranial Arachnoid Cysts in 488 pediatric cases.
abstract: To summarize the clinical characteristics of intracranial arachnoid cysts (IACs) in pediatric cases. A retrospective analysis was carried out on clinical characteristics of IACs in 488 pediatric cases who were treated at our hospital from January 2003 to September 2013. There were 342 males and 146 females (male-to-female ratio, 2.34:1), aged 5.61±3.25 years on average. 221 cases (45.29%) were diagnosed accidentally, 267 cases had clinical complaints (54.71%), among which relationships between clinical complaints and IACs were identified in 123 (46.07%). Simple IACs occurred in 364 cases (4.59%), and concurrent congenital abnormalities occurred in 124 cases (4.59%). In terms of location, 355 had IACs in middle cranial fossa (72.75%), 82 cases in posterior cranial fossa (16.80%), 20 cases in anterior cranial fossa (4.10%), 12 cases in dorsolateral surface (2.46%), 7 cases in suprasellar cistern (1.43%), 5 cases in cerebral ventricle (1.02%), 5 cases in quadrigeminal cistern (1.02%), and 2 cases in interhemispheric region (0.41%). There were 449 cases with single IAC (92.01%) and 39 cases with multiple IACs (7.99%). On MRI, the cysts produced tension in 127 cases (26.02%), but not in the remaining 361 cases (73.98%). Surgery was performed on 76 of 488 cases (15.57%), while conservative observation was accepted in 412 cases (84.43%). For the former, the symptoms and the cyst volume were improved to varying extent; for the latter, the follow-up lasting for 3-72 months (average 32.43±8.92 months) showed that the cyst volume remained stable in 407 cases (98.78%), enlarged with aggravated symptoms in 3 cases (0.73%), and shrank in 2 cases (0.49%). Clinical complaints of IACs varied in pediatric cases, and the relationships between clinical complaints and IACs were established only partially. Some pediatric cases were combined with other congenital abnormalities. The cyst volume largely remained stable during the disease course, and surgery was required for only a few IACs.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University Fuzhou 350005, China.
authors.forename: Jian-Huang
authors.initials: JH
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University Fuzhou 350005, China.
authors.forename: Wen-Zhong
authors.initials: WZ
authors.lastname: Mei
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University Fuzhou 350005, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University Fuzhou 350005, China.
authors.forename: Jian-Wu
authors.initials: JW
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005, China; Beijing Sanbo Brain Hospital, Capital Medical UniversityBeijing 10093, China.
authors.forename: Zhi-Xiong
authors.initials: ZX
authors.lastname: Lin
keywords: Intracranial arachnoid cysts (IACs); clinical symptoms; natural history; pediatric; treatment