title: Development and Function of Arterial and Cardiac Macrophages.
abstract: Macrophages inhabit all major organs, and are capable of adapting their functions to meet the needs of their home tissues. The recent recognition that tissue macrophages derive from different sources, coupled with the notion that environmental cues and inflammatory stimuli can sculpt and agitate homeostasis, provides a frame of reference from which we can decipher the breadth and depth of macrophage activity. Here we discuss macrophages residing in the cardiovascular system, focusing particularly on their development and function in steady state and disease. Central to our discussion is the tension between macrophage ontogeny as a determinant of macrophage function, and the idea that tissues condition macrophage activities and supplant the influence of macrophage origins in favor of environmental demands.
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: fswirski@mgh.harvard.edu.
authors.forename: Filip K
authors.initials: FK
authors.lastname: Swirski
authors.affiliation: Department of Immunology, Toronto General Research Institute, Peter Munk Cardiac Centre, University Health Network and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5G 1L7, Canada.
authors.forename: Clinton S
authors.initials: CS
authors.lastname: Robbins
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Matthias
authors.initials: M
authors.lastname: Nahrendorf
mesh_terms: D000818:Animals; D001158:Arteries / Q000166:cytology*; D050197:Atherosclerosis / Q000473:pathology*; D002454:Cell Differentiation; D047108:Embryonic Development; D006801:Humans; D008264:Macrophages / Q000502:physiology*; D009000:Monocytes / Q000502:physiology; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000166:cytology*