title: Budesonide-loaded solid lipid nanoparticles for pulmonary delivery: preparation, optimization, and aerodynamic behavior.
abstract: Advantages of lipid nanoparticles for pulmonary applications are possibility of deep lung deposition with prolonged release and low toxicity. This study aimed to evaluate the effects of formulation and processing parameters on particle size of prepared SLNs. Budesonide-loaded solid lipid nanoparticles (BUD-SLNs) were prepared with different values of drug content, ultrasonication amplitude, and homogenization time and the data were modeled using artificial neural networks (ANNs). Optimal conditions for fabrication of small-sized particles of 170-200 nm were found to be low drug content with high-amplitude and high-homogenization time. In vitro aerosolization performance of BUD-SLNs was then compared to that of commercial budesonide which indicated enhancement in fine particle fraction value.
authors.affiliation: a Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Esmaeili
authors.affiliation: a Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Aghajani
authors.affiliation: b Department of Biochemistry, Faculty of Medicine, Hamedan University of Medical Sciences , Hamedan , Iran.
authors.forename: Roghayeh
authors.initials: R
authors.lastname: Abbasalipourkabir
authors.affiliation: a Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.|c Medical Biomaterials Research Center, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Amani
mesh_terms: D000280:Administration, Inhalation; D019819:Budesonide / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size
chemical_list: D008055:Lipids; D019819:Budesonide
keywords: Artificial neural networks; budesonide; size; solid lipid nanoparticles; ultra-sonication