title: Bisphenol A exposure may increase the risk of development of atopic disorders in children.
abstract: BACKGROUND
  Little is known about the effect of Bisphenol A (BPA) on atopic disorders.
  
  
  OBJECTIVE
  To investigated the associations (i) between postnatal BPA exposure and allergic diseases in children; (ii) between BPA and IgE levels for the possible disease pathogenesis; and (iii) gender-based differences.
  
  
  METHODS
  A total of 453 children from Childhood Environment and Allergic Diseases Study cohort with urine and blood samples were recruited in Taiwan. Urinary BPA glucoronide (BPAG) levels were measured by UPLC-MS/MS at ages 3 and 6 years. The associations between BPAG levels at different ages and IgE levels and the development of allergic diseases were evaluated by multivariate linear regression and logistic regression. A mediation analysis was also conducted to evaluate how much risk of allergic diseases in relation to BPA exposure is explained by IgE changes.
  
  
  RESULTS
  The BPAG levels at age 3 were positively associated with IgE levels at age 3 (β=64.85kU/l per ln-unit increase BPAG level; 95% CI, 14.59-115.11kU/l). Stratified by gender, BPAG levels at age 3 were positively associated with IgE levels at age 3, particularly in girls (β=139.23kU/l; 95% CI, 57.38-221.09kU/l). Similar results were also found at age 6. Urinary BPAG levels at age 3 were significantly associated with asthma at ages 3 and 6, with OR (95%CI) of 1.29(1.08-1.55) and 1.27(1.04-1.55). We estimated that 70% of the total effect of BPA exposure on asthma is mediated by IgE levels.
  
  
  CONCLUSIONS
  BPA exposures were associated with IgE levels and may increase the risk of development of allergic diseases in children particularly in girls.
authors.affiliation: Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, Taipei, Taiwan; Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Health Risk Management, China Medical University, Taichung, Taiwan. Electronic address: wij636@gmail.com.
authors.forename: I-Jen
authors.initials: IJ
authors.lastname: Wang
authors.affiliation: Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Chia-Yang
authors.initials: CY
authors.lastname: Chen
authors.affiliation: Department of Health, Karlstad University, Karlstad, Sweden.
authors.forename: Carl-Gustaf
authors.initials: CG
authors.lastname: Bornehag
mesh_terms: D001559:Benzhydryl Compounds / Q000633:toxicity* / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D052244:Endocrine Disruptors / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D020719:Glucuronides / Q000652:urine*; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000453:epidemiology* / Q000652:urine; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D016017:Odds Ratio; D010636:Phenols / Q000633:toxicity* / Q000652:urine*; D012306:Risk; D013624:Taiwan; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D020719:Glucuronides; D007073:Immunoglobulin E; D010636:Phenols; C512161:bisphenol A glucuronide; D000098826:Bisphenol A Compounds; C006780:bisphenol A
keywords: Allergic diseases; Bisphenol A; Children; Gender; IgE levels