title: Optimal operational conditions for supercontinuum-based ultrahigh-resolution endoscopic OCT imaging.
abstract: We investigated the optimal operational conditions for utilizing a broadband supercontinuum (SC) source in a portable 800 nm spectral-domain (SD) endoscopic OCT system to enable high resolution, high-sensitivity, and high-speed imaging in vivo. A SC source with a 3-dB bandwidth of ∼246  nm was employed to obtain an axial resolution of ∼2.7  μm (in air) and an optimal detection sensitivity of ∼-107  dB with an imaging speed up to 35 frames/s (at 70 k A-scans/s). The performance of the SC-based SD-OCT endoscopy system was demonstrated by imaging guinea pig esophagus in vivo, achieving image quality comparable to that acquired with a broadband home-built Ti:sapphire laser.
authors.forename: Wu
authors.initials: W
authors.lastname: Yuan
authors.forename: Jessica
authors.initials: J
authors.lastname: Mavadia-Shukla
authors.forename: Jiefeng
authors.initials: J
authors.lastname: Xi
authors.forename: Wenxuan
authors.initials: W
authors.lastname: Liang
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Yu
authors.forename: Shaoyong
authors.initials: S
authors.lastname: Yu
authors.forename: Xingde
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D004724:Endoscopy / Q000379:methods*; D006168:Guinea Pigs; D007091:Image Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D041623:Tomography, Optical Coherence / Q000379:methods*