title: Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?
abstract: Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potentiate pulmonary disease. Accordingly, levels of antibodies to three CMV antigen preparations were higher in NTM patients than in age-matched controls. This did not reflect broad-spectrum B cell activation as total immunoglobulin levels were not equivalently increased.
authors.affiliation: School of Laboratory & Pathology Medicine, University of Western Australia, Nedlands, Australia.
authors.forename: Fathiah S
authors.initials: FS
authors.lastname: Amran
authors.affiliation: School of Laboratory & Pathology Medicine, University of Western Australia, Nedlands, Australia.
authors.forename: Kyungchul
authors.initials: K
authors.lastname: Kim
authors.affiliation: School of Laboratory & Pathology Medicine, University of Western Australia, Nedlands, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Lim
authors.affiliation: School of Medicine, University of Queensland, Brisbane, QLD, Australia.|Greenslopes Private Hospital, Brisbane, QLD, Australia.
authors.forename: Rachel
authors.initials: R
authors.lastname: Thomson
authors.affiliation: Department of Microbiology, Royal Perth Hospital, Perth, Australia.
authors.forename: Silvia
authors.initials: S
authors.lastname: Lee
authors.affiliation: School of Medicine & Pharmacology, University of Western Australia, Nedlands, Australia.
authors.forename: Grant
authors.initials: G
authors.lastname: Waterer
authors.affiliation: School of Medicine & Pharmacology, University of Western Australia, Nedlands, Australia. patricia.price@curtin.edu.au.|School of Biomedical Science, Curtin University, GPO Box U1987, Bentley, Perth, Western Australia, 6845. patricia.price@curtin.edu.au.
authors.forename: Patricia
authors.identifier: http://orcid.org/0000-0003-3078-4451
authors.initials: P
authors.lastname: Price
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D016022:Case-Control Studies; D060085:Coinfection; D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology*; D018410:Pneumonia, Bacterial / Q000382:microbiology*; D017735:Virus Latency
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral
keywords: Cytomegalovirus; immunosuppression; non-tuberculous mycobacteria