title: A Firming Neck Cream Containing N-Acetyl Glucosamine Significantly Improves Signs of Aging on the Challenging Neck and Décolletage.
abstract: BACKGROUND
  Noninvasive antiaging neck and décolletage treatments are highly sought after by aging patients. A topical cosmetic antiaging cream was formulated with skin matrix building and smoothing ingredients to help reverse visible signs of aging on the neck and décolletage, including laxity, crepiness, deep lines, and hyperpigmentation.
  
  
  OBJECTIVE
  A clinical study was conducted to evaluate the efficacy and safety of the antiaging neck/décolletage cream over a 16-week treatment period.
  
  
  METHODS
  Caucasian women with moderate texture (including wrinkles, fine lines, laxity, and/or crepiness) on the neck and hyperpigmentation on the décolletage used the test cream for 16 weeks. At weeks 0, 8, 12 and 16, the dermatologist investigator graded neck texture, décolletage texture and décolletage pigmentation using a 0-5 scale, and irritation/tolerability using a 0-4 scale. Subjects were photographed and provided self-assessment of their aging parameters as well as product tolerability. Chromameter measurements were collected in triplicate on the chest at weeks 0, 8, and 16 to quantitatively and objectively assess pigmentation.
  
  
  RESULTS
  Forty-two women completed the study. All dermatologist-graded aging parameters were significantly improved at each time point, P<0.001. Chromameter measurements demonstrated significant improvements in brightness (L*) and redness (a*), P<0.05. Self-assessed aging parameters were significantly improved on the décolletage and neck, P<0.05. Digital photography demonstrated obvious antiaging effects including improved texture of neck and décolletage areas, reduced appearance of lines and wrinkles, reduced mottled hyperpigmentation, and a more youthful, firm appearance. The test cream was well-tolerated with no significant changes in irritation parameters throughout the study.
  
  
  CONCLUSIONS
  The antiaging neck/décolletage cream delivered significant firming and smoothing effects with reduced appearance of hyperpigmentation and can be considered an effective topical homecare treatment option for patients seeking rejuvenation of this challenging area
authors.forename: Joel
authors.initials: J
authors.lastname: Schlessinger
authors.forename: Barbara
authors.initials: B
authors.lastname: Green
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Edison
authors.forename: Lynn
authors.initials: L
authors.lastname: Murphy
authors.forename: Yamini
authors.initials: Y
authors.lastname: Sabherwal
mesh_terms: D000117:Acetylglucosamine / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D002626:Chemistry, Pharmaceutical; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy*; D008875:Middle Aged; D009333:Neck; D009824:Ointments; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D009824:Ointments; D000117:Acetylglucosamine