title: The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases.
abstract: The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the central nervous system. Tailess and Tlx, the TLX homologues in Drosophila and mouse, play essential roles in body-pattern formation and neurogenesis during early embryogenesis and perform crucial functions in maintaining stemness and controlling the differentiation of adult neural stem cells in the central nervous system, especially the visual system. Multiple target genes and signaling pathways are regulated by TLX and its homologues in specific tissues during various developmental stages. This review aims to summarize previous studies including many recent updates from different aspects concerning TLX and its homologues in Drosophila and mouse.
authors.affiliation: Department of Intensive Care, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Intensive Care, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. Jianqxicu@163.com.
authors.forename: Jian-Qiong
authors.initials: JQ
authors.lastname: Xiong
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000378:metabolism*; D004330:Drosophila; D006801:Humans; D051379:Mice; D058953:Neural Stem Cells / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
chemical_list: C088601:NR2E1 protein, human; C490258:Nr2e1 protein, mouse; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear
keywords: Neural stem cell; Neurogenesis; TLX