title: Primary Debulking Surgery Versus Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer: A Propensity-matched Analysis.
abstract: To compare the surgical and survival outcomes of patients undergoing primary debulking surgery (PDS) versus neoadjuvant chemotherapy (NACT) plus interval debulking surgery (IDS) for advanced epithelial ovarian cancer (EOC).
  
  
  
  Consecutive patients managed for advanced EOC since 2009 were matched through a propensity score analysis, defined as the probability of a woman having PDS or NACT plus IDS.
  
  
  
  The study group consisted of 100 propensity-matched women receiving PDS or NACT plus IDS. Groups resulted homogeneous in terms of baseline characteristics and pathologic findings. Patients undergoing PDS had longer operative time (P=0.032) and more blood loss (P=0.011) than the counterpart receiving NACT. No differences were found in terms of residual disease (P=0.11), as well as in terms of hospitalization, intraoperative, and postoperative complications. The mean progression-free survival was 23.0 and 27.7 months (P=0.67), whereas the overall survival (OS) was 44.5 and 43.2 months (P=0.48) for the PDS and NACT plus IDS group, respectively. Residual disease (P<0.0001) was the only independent predictor of progression-free and OS at multivariate analysis.
  
  
  
  PDS and NACT plus IDS achieved comparable results in terms of progression-free and OS in patients with advanced EOC.
authors.affiliation: Gynecologic Unit.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Siesto
authors.affiliation: Medical Oncology and Hematology Unit, Cancer Center, Humanitas Clinical and Research Center, Milan, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Cavina
authors.affiliation: Gynecologic Unit.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Romano
authors.affiliation: Gynecologic Unit.
authors.forename: Domenico
authors.initials: D
authors.lastname: Vitobello
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000077216:Carcinoma, Ovarian Epithelial / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D065426:Cytoreduction Surgical Procedures; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods; D010052:Ovariectomy / Q000379:methods*; D000077982:Progression-Free Survival; D057216:Propensity Score; D016016:Proportional Hazards Models
chemical_list: D000970:Antineoplastic Agents