title: Prognostic factors of primary resected retroperitoneal soft tissue sarcoma: Analysis from a single asian tertiary center and external validation of gronchi's nomogram.
abstract: BACKGROUND
  Surgery is the potentially curative treatment for retroperitoneal sarcoma (RS), but complete resectability is frequently a challenge. This study aimed to characterize the clinical features, prognostic factors and treatment outcomes.
  
  
  METHODS
  A cohort of 144 patients with RS was surveyed retrospectively from January 1st, 2000 to July 30th, 2011. The prognostic influence of clinicopathological characteristics as well as treatments on local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS), were examined by univariate and multivariate analyses. A histology-specific nomogram developed by Gronchi et al was used for validation.
  
  
  RESULTS
  Liposarcoma, leiomyosarcoma, and malignant peripheral sheath tumor (MPNST) were the most common histologies (70%). Multivariate analysis revealed FNCLCC tumor grade was the most significant prognostic factor for OS (P = 0.001) and DMFS (P < 0.001) and complete resection was the only significant prognostic factor for LRFS (P = 0.043). Incomplete resection of grade 3 tumor was significantly associated with a worse OS. Despite some differences in characteristics between our patients and Gronchi's cohort, external validation of Gronchi's nomogram demonstrated excellent concordance in predicting survival.
  
  
  CONCLUSIONS
  Our study demonstrated tumor grade and surgical margins had significant prognostic influence and the Gronchi's nomogram has an excellent applicability in predicting survival of STS patients. J. Surg. Oncol. 2016;113:355-360. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.|Division of Hematology and Oncology, Department of Medicine, Lo-Hsu Foundation, Lotung Poh-Ai Hospital, Luodong, Yilan, Taiwan.
authors.forename: Yi-Sheng
authors.initials: YS
authors.lastname: Chou
authors.affiliation: Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Liu
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan.|Department of Urology and Shu-Tien Urological Research Center, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Yen-Hwa
authors.initials: YH
authors.lastname: Chang
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Kuang-Liang
authors.initials: KL
authors.lastname: King
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Paul Chih-Hsueh
authors.initials: PC
authors.lastname: Chen
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Chin-Chen
authors.initials: CC
authors.lastname: Pan
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Shu-Huei
authors.initials: SH
authors.lastname: Shen
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Liu
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Alex T L
authors.initials: AT
authors.lastname: Lin
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Kuang-Kuo
authors.initials: KK
authors.lastname: Chen
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shyr
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Rheun-Chuan
authors.initials: RC
authors.lastname: Lee
authors.affiliation: Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Ta-Chung
authors.initials: TC
authors.lastname: Chao
authors.affiliation: Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Muh-Hwa
authors.initials: MH
authors.lastname: Yang
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Lo-Hsu Foundation, Lotung Poh-Ai Hospital, Luodong, Yilan, Taiwan.
authors.forename: Chung-Huang
authors.initials: CH
authors.lastname: Chan
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Lo-Hsu Foundation, Lotung Poh-Ai Hospital, Luodong, Yilan, Taiwan.
authors.forename: Jie-Yu
authors.initials: JY
authors.lastname: You
authors.affiliation: Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Chueh-Chuan
authors.initials: CC
authors.lastname: Yen
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049451:Nomograms; D011379:Prognosis; D015203:Reproducibility of Results; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D013624:Taiwan; D062606:Tertiary Care Centers
keywords: nomogram; prognostic factor; retroperitoneal sarcoma