title: Association Between Interleukin-1A, Interleukin-1B, and Bridging integrator 1 Polymorphisms and Alzheimer's Disease: a standard and Cumulative Meta-analysis.
abstract: Alzheimer's disease (AD) has been one of the most prevalent health problems among senior population. Interleukin-1A (IL-1A) and IL-1B are two isoforms of IL-1. Recent studies suggested that certain polymorphisms on these two genes are associated with AD. Bridging integrator 1 (BIN1) is considered as common genetic risk factors for AD, whereas different studies have provided various conclusions regarding its role in AD. This study was designed to justify the association between multiple gene polymorphisms and AD through an evidence synthesis approach. We conducted a literature search to identify relevant articles published from 2000 to 2015 from PubMed, Embase, and Cochrane Library, in accordance with inclusion criteria. Pooled odds ratios (ORs) were calculated for the allele model. The effect estimates were summarized by both standard and cumulative meta-analysis. Finally, 54 articles with 88 independent studies were enrolled in this meta-analysis. Mutants in rs1800587 of IL-1A, rs1143634 of IL-1B, rs12989701, and rs744373 of BIN1 were significantly associated with AD onset. The difference effect of same single nucleotide polymorphisms (SNPs) on various ethnicities was also observed in our results. The present meta-analysis suggested that IL-1A, IL-1B, and BIN1 were candidate genes for AD pathogenesis. Polymorphisms of IL-1A, IL-1B, and BIN1 are associated with AD onset.
authors.affiliation: Department of Neurology, Tangshan People's Hospital, Tangshan, 063000, China. xiaoliu_dong@yeah.net.
authors.forename: Xiaoliu
authors.initials: X
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, Tangshan People's Hospital, Tangshan, 063000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Internal Medicine, The People's Hospital of Qianxi County, Qianxi, 064300, China.
authors.forename: Qingling
authors.initials: Q
authors.lastname: Meng
authors.affiliation: Department of Ultrasound, Tangshan People's Hospital, Tangshan, 063000, China.
authors.forename: Qiuyan
authors.initials: Q
authors.lastname: Gao
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies / Q000379:methods*; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C101410:BIN1 protein, human; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D009687:Nuclear Proteins; D025521:Tumor Suppressor Proteins
keywords: Alzheimer disease; Bridging integrator 1; Genetic association; Interleukin-1; Meta-analysis