title: [Sézary syndrome treated with extracorporeal photopheresis: Report of one case].
abstract: Sézary syndrome (SS) is an unusually aggressive T- cell lymphoma characterized by the triad of erythroderma, the presence of more than 1,000 Sézary cells in peripheral blood and lymphadenopathies. It is accompanied by generalized pruritus and poor quality of life. The management of SS depends on its stage, patient comorbidities, and treatment availability. Extracorporeal photopheresis (ECP) is the first line of treatment for patients with T-cell lymphomas in stage IVA1, IVA2 or SS. This treatment comprises three phases: leukapheresis, photoactivation and subsequent reinfusion of lymphocytes. As it is an immunomodulatory therapy it does not produce generalized immunosuppression. We report a 76 year-old male with SS stage IIIb initially treated with 12 sessions of ultraviolet phototherapy without response. After 10 well-tolerated sessions of ECP, itching and skin lesions eventually disappeared.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Molgó
authors.forename: Alejandra
authors.initials: A
authors.lastname: Jaque
authors.forename: Verónica
authors.initials: V
authors.lastname: Vial
authors.forename: Mauricio
authors.initials: M
authors.lastname: Ocqueteau
authors.forename: Jaime
authors.initials: J
authors.lastname: Pereira
authors.forename: Mayling
authors.initials: M
authors.lastname: Chang
authors.forename: Sergio
authors.initials: S
authors.lastname: González
mesh_terms: D000368:Aged; D001706:Biopsy; D005347:Fibroblasts / Q000473:pathology; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D017893:Photopheresis / Q000379:methods*; D011537:Pruritus / Q000473:pathology; D012074:Remission Induction / Q000379:methods; D012751:Sezary Syndrome / Q000473:pathology / Q000628:therapy*; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*