title: Genetic effects on source level evoked and induced oscillatory brain responses in a visual oddball task.
abstract: Stimuli in simple oddball target detection paradigms cause evoked responses in brain potential. These responses are heritable traits, and potential endophenotypes for clinical phenotypes. These stimuli also cause responses in oscillatory activity, both evoked responses phase-locked to stimulus presentation and phase-independent induced responses. Here, we investigate whether phase-locked and phase-independent oscillatory responses are heritable traits. Oscillatory responses were examined in EEG recordings from 213 twin pairs (91 monozygotic and 122 dizygotic twins) performing a visual oddball task. After group Independent Component Analysis (group-ICA) and time-frequency decomposition, individual differences in evoked and induced oscillatory responses were compared between MZ and DZ twin pairs. Induced (phase-independent) oscillatory responses consistently showed the highest heritability (24-55%) compared to evoked (phase-locked) oscillatory responses and spectral energy, which revealed lower heritability at 1-35.6% and 4.5-32.3%, respectively. Since the phase-independent induced response encodes functional aspects of the brain response to target stimuli different from evoked responses, we conclude that the modulation of ongoing oscillatory activity may serve as an additional endophenotype for behavioral phenotypes and psychiatric genetics.
authors.affiliation: School of Electronic and Computer Engineering, Technical University of Crete, Chania 73100, Greece. Electronic address: mantonakakis@isc.tuc.gr.
authors.forename: Marios
authors.initials: M
authors.lastname: Antonakakis
authors.affiliation: School of Electronic and Computer Engineering, Technical University of Crete, Chania 73100, Greece.
authors.forename: Michalis
authors.initials: M
authors.lastname: Zervakis
authors.affiliation: Biological Psychology, VU University, van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands.
authors.forename: Catharina E M
authors.initials: CE
authors.lastname: van Beijsterveldt
authors.affiliation: Biological Psychology, VU University, van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
authors.affiliation: Biological Psychology, VU University, van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.
authors.forename: Eco J C
authors.initials: EJ
authors.lastname: De Geus
authors.affiliation: School of Electronic and Computer Engineering, Technical University of Crete, Chania 73100, Greece; Faculty of Medicine, University of Crete, Heraklion 71110, Greece.
authors.forename: Sifis
authors.initials: S
authors.lastname: Micheloyannis
authors.affiliation: Biological Psychology, VU University, van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.
authors.forename: Dirk J A
authors.initials: DJ
authors.lastname: Smit
mesh_terms: D000293:Adolescent; D001683:Biological Clocks / Q000235:genetics*; D001921:Brain / Q000502:physiology; D004569:Electroencephalography; D058068:Endophenotypes; D005074:Evoked Potentials, Visual / Q000235:genetics*; D005824:Genetics, Behavioral; D006801:Humans; D007206:Individuality; D009426:Netherlands; D010775:Photic Stimulation / Q000379:methods; D013647:Task Performance and Analysis; D014429:Twins, Dizygotic / Q000235:genetics
keywords: EEG; Endophenotype; Heritability; ICA; P300; Time-frequency analysis; Twin study