title: Nitrosoureas in the Management of Malignant Gliomas.
abstract: Nitrosoureas represent one of the most active classes of agents in the treatment of high-grade gliomas and glioblastoma. In clinical practice, the most commonly used compounds are lomustine (either alone or in combination with procarbazine and vincristine), carmustine, and fotemustine. Given their toxicity profile and subsequent to the introduction of temozolomide in clinical practice, most of these agents were moved to the recurrent setting. This review focuses on the role of the nitrosoureas currently used in clinical practice for the treatment of malignant gliomas.
authors.affiliation: Department of Medical Oncology, Bellaria Hospital, Azienda USL - IRCCS Institute of Neurological Sciences, Via Altura 3, 40139, Bologna, Italy. alba.brandes@yahoo.it.
authors.forename: Alba A
authors.initials: AA
authors.lastname: Brandes
authors.affiliation: Department of Medical Oncology, Bellaria Hospital, Azienda USL - IRCCS Institute of Neurological Sciences, Via Altura 3, 40139, Bologna, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bartolotti
authors.affiliation: Department of Medical Oncology, Bellaria Hospital, Azienda USL - IRCCS Institute of Neurological Sciences, Via Altura 3, 40139, Bologna, Italy.
authors.forename: Alicia
authors.initials: A
authors.lastname: Tosoni
authors.affiliation: Department of Medical Oncology, Bellaria Hospital, Azienda USL - IRCCS Institute of Neurological Sciences, Via Altura 3, 40139, Bologna, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Franceschi
mesh_terms: D003606:Dacarbazine / Q000031:analogs & derivatives; D005910:Glioma / Q000473:pathology; D006801:Humans; D008130:Lomustine; D009607:Nitrosourea Compounds; D009943:Organophosphorus Compounds; D011344:Procarbazine; D000077204:Temozolomide; D014750:Vincristine
chemical_list: D009607:Nitrosourea Compounds; D009943:Organophosphorus Compounds; D011344:Procarbazine; D014750:Vincristine; D008130:Lomustine; D003606:Dacarbazine; C054368:fotemustine; D000077204:Temozolomide
keywords: Anaplastic; Chemotherapy; Glioblastoma; Glioma; Nitrosoureas