title: The effects of bupropion on hybrid striped bass brain chemistry and predatory behavior.
abstract: Increased use of antidepressants has led to an increase in their detection in final treated wastewater effluents and receiving streams. Antidepressants are intended to modify human behavior by altering brain chemistry, and because of the high functional conservation of antidepressant target receptors in vertebrates, aquatic organisms may be at risk. The antidepressant bupropion is designed to alter brain norepinephrine and dopamine concentrations in humans. The objective of the present study was to understand if alteration of dopaminergic neurotransmitter concentrations in the hybrid striped bass (Morone saxatilis × Morone chrysops) brain by bupropion would alter this predator's ability to capture prey. The authors exposed hybrid striped bass to bupropion in a static system for 6 d, followed by a 6-d recovery period. During the present study's 12-d experiment, each hybrid striped bass was fed 4 unexposed fathead minnows every 3 d, and the time it took the hybrid striped bass to consume each of those 4 fathead minnows was quantified. After each feeding event, hybrid striped bass brains were harvested and analyzed for changes in several brain neurotransmitter concentrations, including serotonin, norepinephrine, dopamine, and many of their metabolites. Although bupropion altered the concentration of dopamine and many of the dopaminergic neurotransmitter metabolite concentrations in the brains on day 3 of the exposure, it did not alter the time to capture prey. This suggests that alteration of dopaminergic neurotransmitter concentrations in the hybrid striped bass brain does not alter a predator's ability to capture prey. Environ Toxicol Chem 2016;35:2058-2065. © 2016 SETAC.
authors.affiliation: Institute of Environmental Toxicology, Clemson University, Clemson, South Carolina, USA.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Sweet
authors.affiliation: Department of Environmental and Global Health, Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida, USA.
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Bisesi
authors.affiliation: State Key Laboratory for Marine Pollution, Department of Biology & Chemistry, City University of Hong Kong, Hong Kong SAR, China.
authors.forename: E N Y
authors.initials: EN
authors.lastname: Lei
authors.affiliation: State Key Laboratory for Marine Pollution, Department of Biology & Chemistry, City University of Hong Kong, Hong Kong SAR, China.
authors.forename: Michael H W
authors.initials: MH
authors.lastname: Lam
authors.affiliation: Institute of Environmental Toxicology, Clemson University, Clemson, South Carolina, USA.|Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA.|Water Research Group (Ecotoxicology), Unit for Environmental Sciences and Management, North West University, Potchefstroom Campus, Potchefstroom, South Africa.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Klaine
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000633:toxicity*; D001492:Bass / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D016642:Bupropion / Q000633:toxicity*; D004298:Dopamine / Q000378:metabolism; D004784:Environmental Monitoring; D011235:Predatory Behavior / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000928:Antidepressive Agents; D014874:Water Pollutants, Chemical; D016642:Bupropion; D012701:Serotonin; D004298:Dopamine
keywords: Antidepressant; Behavior; Bupropion; Fish; Neurotransmitter