title: [Cytomegalovirus reactivation and steroid refractory are the independent risk factors for colonic surgery in ulcerative colitis].
abstract: OBJECTIVE
  To explore the risk factors of surgery in patients with ulcerative colitis (UC).
  
  
  METHODS
  Patients with UC, hospitalized from January 2005 to October 2012 were retrospectively enrolled in this study. Univariate and multivariate analyses were used to reveal the risk factors of colon surgery, including demographic features, clinical manifestations, laboratory examinations and medication.
  
  
  RESULTS
  A total of 273 UC patients were enrolled in this study with 39 (14.3%) patients receiving colon surgery. Compared with the flare group, patients in surgery group 71.8% (28/39) had more proportion with severe disease (P=0.008), higher prevalence of active cytomegalovirus (CMV) infection [47.6% (10/21) vs 10.9% (11/101), P<0.001], higher ratio of steroid resistance [60.0% (15/25) vs 10.7% (18/168), P<0.001], more receiving cyclosporine A [28.2% (11/39) vs 7.3% (17/234), P<0.001], and lesser with 5-aminosalicylic acid [82.1% (32/39) vs 95.3% (223/234), P=0.007]. Based on multivariate logistic regression analyses, active CMV infection and steroid resistance were two independent risk factors of colon surgery in UC patients (P=0.006 and 0.030, OR=6.040 and 17.928).
  
  
  CONCLUSIONS
  Active CMV infection and steroid resistance are independent risk factors of colon surgery in UC.
authors.affiliation: Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Li
authors.forename: Mingming
authors.initials: M
authors.lastname: Wei
authors.forename: Bei
authors.initials: B
authors.lastname: Tan
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Lyu
authors.forename: Liying
authors.initials: L
authors.lastname: Wang
authors.forename: Jingnan
authors.initials: J
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Email: qianjiaming1957@126.com.
authors.forename: Jiaming
authors.initials: J
authors.lastname: Qian
mesh_terms: D003093:Colitis, Ulcerative / Q000601:surgery* / Q000821:virology*; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000150:complications*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D015999:Multivariate Analysis; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors