title: The Practicality of Targeted Prostate Biopsy Procedures on the Dominant Side of the Tumor Determined by Magnetic Resonance Imaging in Elderly Patients with High Serum Levels of Prostate-Specific Antigen.
abstract: OBJECTIVE
  To examine the possibility of reducing the number of cores per prostate biopsy in elderly patients with high levels of prostate-specific antigen (PSA) without significantly lowering the detection rate of prostate cancer.
  
  
  METHODS
  Two hundreds sixteen men with PSA levels >20 ng/mL who underwent prostate biopsies from May 2009 to April 2013 were retrospectively reviewed. With the help of magnetic resonance imaging (MRI), the laterality of the dominant tumor burden in patients was determined. The results of targeted biopsies were compared with those of conventional biopsy procedures.
  
  
  RESULTS
  The mean age and PSA level were 79.5 years and 81.3 ng/mL, respectively, and the overall diagnostic rate of sextant biopsies was 81.9% (177/216). MRI was able to show the tumor burden in 189 of the 216 patients. The detection rate of transrectal ultrasonography (TRUS)-guided targeted biopsies was 87.3% (165/189). Detection rates were comparable with conventional biopsies (81.9% [177/216]) (p=0.23). Of the 177 men in whom the results of the sextant biopsy were positive, 12 men (6.8%) with PSA levels <29 ng/mL did not have any cancer cells according to targeted biopsies. However, all other patients were diagnosed with prostate cancer using the abovementioned techniques.
  
  
  CONCLUSIONS
  We believe that TRUS-guided targeted biopsies of the prostate in elderly men with high PSA levels could reduce the number of unnecessary cores per biopsy. However, a risk of detection loss remains. Therefore, we recommend that at least a sextant biopsy should be performed, even in elderly patients, in order to detect prostate cancer.
authors.affiliation: Department of Urology, Jeju National University School of Medicine, Jeju, Korea.
authors.forename: Jung Sik
authors.initials: JS
authors.lastname: Huh
authors.affiliation: Department of Radiology, Jeju National University School of Medicine, Jeju, Korea.
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Department of Urology, Jeju National University School of Medicine, Jeju, Korea.
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Urology, Jeju National University School of Medicine, Jeju, Korea.
authors.forename: Sung Dae
authors.initials: SD
authors.lastname: Kim
authors.affiliation: Department of Urology, Jeju National University School of Medicine, Jeju, Korea.
authors.forename: Kyung Kgi
authors.initials: KK
authors.lastname: Park
keywords: Aged; Biopsy; Magnetic resonance imaging; Prostate-specific antigen; Prostatic neoplasms