title: Circulating ANGPTL8/Betatrophin Concentrations Are Increased After Surgically Induced Weight Loss, but Not After Diet-Induced Weight Loss.
abstract: ANGPTL8/betatrophin is a secreted protein reported to be involved in β-cell replication that has recently been shown to be more related to lipid metabolism. Weight loss represents a clinical situation of improvement of glucose homeostasis and overall metabolic control. The aim of the present study was to analyze the impact of weight loss induced by either a conventional dietary treatment or bariatric surgery on ANGPTL8/betatrophin concentrations.
  
  
  
  Serum concentrations of ANGPTL8/betatrophin were measured by ELISA in 158 subjects before and 1 year after weight loss induced either by conventional dietary treatment (n = 38) or bariatric surgery (sleeve gastrectomy, n = 20, or Roux-en-Y gastric bypass, n = 100).
  
  
  
  Massive surgery-induced weight loss after SG or RYGB was accompanied by a statistically significant increase in circulating levels of ANGPTL8/betatrophin (28.1 ± 13.9 to 40.3 ± 22.8 ng/mL, P = 0.001 after SG; 24.6 ± 10.9 to 41.7 ± 19.4 ng/mL, P < 0.001 after RYGB), while remaining unchanged 25.6 ± 13.3 to 25.4 ± 10.7 ng/mL (P = 0.891) after diet-induced weight loss. The change in ANGPTL8/betatrophin levels was positively correlated with the change in HDL-C concentrations.
  
  
  
  Our study showed that serum ANGPTL8/betatrophin concentrations were increased in obese subjects after surgically induced weight loss, but not after weight loss achieved by conventional dietary treatment. The change in ANGPTL8/betatrophin concentrations emerged as a significant predictor of the change in HDL-C levels after weight loss.
authors.affiliation: Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Avda. Pío XII 36, 31008, Pamplona, Spain.
authors.forename: Eider
authors.initials: E
authors.lastname: Pascual-Corrales
authors.affiliation: Metabolic Research Laboratory, University of Navarra, Pamplona, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.|Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Gómez-Ambrosi
authors.affiliation: CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.|Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.|Department of Anesthesia, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Moncada
authors.affiliation: CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.|Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.|Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Valentí
authors.affiliation: Metabolic Research Laboratory, University of Navarra, Pamplona, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.|Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Catalán
authors.affiliation: Metabolic Research Laboratory, University of Navarra, Pamplona, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.|Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.
authors.forename: Amaia
authors.initials: A
authors.lastname: Rodríguez
authors.affiliation: Metabolic Research Laboratory, University of Navarra, Pamplona, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.|Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Ramírez
authors.affiliation: Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Avda. Pío XII 36, 31008, Pamplona, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.|Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.
authors.forename: Camilo
authors.initials: C
authors.lastname: Silva
authors.affiliation: CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.|Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.|Department of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Gil
authors.affiliation: Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Avda. Pío XII 36, 31008, Pamplona, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.|Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Salvador
authors.affiliation: Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Avda. Pío XII 36, 31008, Pamplona, Spain. gfruhbeck@unav.es.|Metabolic Research Laboratory, University of Navarra, Pamplona, Spain. gfruhbeck@unav.es.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain. gfruhbeck@unav.es.|Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain. gfruhbeck@unav.es.
authors.forename: Gema
authors.initials: G
authors.lastname: Frühbeck
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins / Q000097:blood*; D050110:Bariatric Surgery; D004038:Diet, Reducing; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D036361:Peptide Hormones / Q000097:blood*; D015431:Weight Loss; D055815:Young Adult
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D036361:Peptide Hormones
keywords: ANGPTL8; Bariatric surgery; Betatrophin; Obesity; Weight loss