title: Association between left ventricular end-diastolic pressure and coronary artery disease as well as its extent and severity.
abstract: Patients with myocardial ischemia exhibit increased left ventricular end-diastolic pressure (LVEDP). The study was to evaluate the relationship between LVEDP measured by left cardiac catheterization and coronary artery disease (CAD) as well as its extent and severity evaluated by coronary angiography (CAG). 912 patients who underwent CAG and left cardiac catheterization were enrolled. There were 313 patients without CAD and 599 with CAD according to CAG. The extent and severity of coronary artery was evaluated by number of vessels and Gensini score. Analyze the correlation of LVEDP and CAD as well as its extent and severity. LVEDP was significantly higher in CAD patients than non-CAD (9.58±5.78 mmHg vs 10.9±5.46 mmHg, P<0.001), and was correlated independently with the presence of CAD (OR = 0.11, per 5 mmHg increase, 95% CI 1.02-1.29, P = 0.02). LVEDP was increased with an increase of number of vessels. By linear regression analysis, LVEDP was significantly associated with Gensini score (standardized β = 0.034, P = 0.001). In non-CAD group, LVEDP was only correlated with age (r = 0.123, P = 0.030). In conclusion, our findings suggest that elevated LVEDP was significantly associated with CAD as well as its extent and severity. LVEDP was only correlated with age in non-CAD patients. LVEDP measurement provides incremental clinical value for CAD and non-CAD patients.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Henan Science and Technology University Luoyang 471003, China.
authors.forename: Lai-Jing
authors.initials: LJ
authors.lastname: Du
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Henan Science and Technology University Luoyang 471003, China.
authors.forename: Ping-Shuan
authors.initials: PS
authors.lastname: Dong
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Henan Science and Technology University Luoyang 471003, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Jia
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Henan Science and Technology University Luoyang 471003, China.
authors.forename: Xi-Mei
authors.initials: XM
authors.lastname: Fan
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Henan Science and Technology University Luoyang 471003, China.
authors.forename: Xu-Ming
authors.initials: XM
authors.lastname: Yang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Henan Science and Technology University Luoyang 471003, China.
authors.forename: Shao-Xin
authors.initials: SX
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Henan Science and Technology University Luoyang 471003, China.
authors.forename: Xi-Shan
authors.initials: XS
authors.lastname: Yang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Henan Science and Technology University Luoyang 471003, China.
authors.forename: Zhi-Juan
authors.initials: ZJ
authors.lastname: Li
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Henan Science and Technology University Luoyang 471003, China.
authors.forename: Hong-Lei
authors.initials: HL
authors.lastname: Wang
keywords: Coronary artery disease; Gensini score; left ventricular end-diastolic pressure