title: MAESTROweb: a web server for structure-based protein stability prediction.
abstract: The prediction of change in stability upon point mutations in proteins has many applications in protein analysis and engineering. We recently adjoined a new structure-based method called MAESTRO, which is distributed as command line program. We now provide access to the most important features of MAESTRO by an easy to use web service. MAESTROweb allows the prediction of change in stability for user-defined mutations, provides a scan functionality for the most (de)stabilizing n-point mutations for a maximum of n = 5, creates mutation sensitivity profiles and evaluates potential disulfide bonds. MAESTROweb operates on monomers, multimers and biological assemblies as defined by PDB.
  
  
  
  MAESTROweb is freely available for non-commercial use at https://biwww.che.sbg.ac.at/maestro/web
  
  
  
  peter.lackner@sbg.ac.at.
authors.affiliation: Department of Molecular Biology, University of Salzburg, Salzburg 5020 School of Informatics, Communications and Media, University of Applied Sciences Upper Austria, Hagenberg 4232, Austria.
authors.forename: Josef
authors.initials: J
authors.lastname: Laimer
authors.affiliation: School of Informatics, Communications and Media, University of Applied Sciences Upper Austria, Hagenberg 4232, Austria.
authors.forename: Julia
authors.initials: J
authors.lastname: Hiebl-Flach
authors.affiliation: School of Informatics, Communications and Media, University of Applied Sciences Upper Austria, Hagenberg 4232, Austria.
authors.forename: Daniel
authors.initials: D
authors.lastname: Lengauer
authors.affiliation: Department of Molecular Biology, University of Salzburg, Salzburg 5020.
authors.forename: Peter
authors.initials: P
authors.lastname: Lackner
mesh_terms: D003201:Computers; D055550:Protein Stability; D011506:Proteins / Q000737:chemistry*; D012984:Software; D064878:Web Browser
chemical_list: D011506:Proteins