title: Effect of preoperative statin therapy on early postoperative memory impairment after off-pump coronary artery bypass surgery.
abstract: BACKGROUND
  Frequent incidence of early postoperative memory impairment (POMI) after cardiac surgery remains a concern because of associated morbidity, impaired quality of life, and increased health care cost.
  
  
  OBJECTIVE
  To assess the effect of preoperative statin therapy on POMI in patients undergoing off-pump coronary artery bypass (OPCAB) surgery.
  
  
  METHODS
  Prospective observational study in a tertiary level hospital.
  
  
  METHODS
  Sixty patients aged 45-65 years undergoing OPCAB surgery were allocated into two groups of 30 each. Group A patients were receiving statin and Group B patients were not receiving statins. All patients underwent memory function assessment preoperatively after admission to hospital and on the 6 th postoperative day using postgraduate institute memory scale.
  
  
  METHODS
  Appropriate tests were applied with SPSS 20 to compare both groups. The value P < 0.05 was considered statistically significant. Multiple regression analysis was performed with confounding factors to determine the effect on memory impairment.
  
  
  RESULTS
  Patients in Group A showed significant postoperative deterioration in 6 of the 10 functions and in Group B showed deterioration in 9 of 10 functions tested compared to preoperative scores. Intergroup comparison detected less POMI in Group A compared to Group B and was statistically significant in 8 memory functions. Multiple regression analysis detected statin as an independent factor in preventing memory impairment.
  
  
  CONCLUSIONS
  Preoperative statin therapy attenuates the early POMI in patients undergoing OPCAB. Future long-term studies will define the efficacy of statin on POMI.
authors.affiliation: Department of Cardiac Anaesthesia, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sambhunath
authors.initials: S
authors.lastname: Das
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Nanda
authors.forename: Akshya K
authors.initials: AK
authors.lastname: Bisoi
authors.forename: Ashima N
authors.initials: AN
authors.lastname: Wadhawan
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007430:Intraoperative Care / Q000379:methods*; D007902:Length of Stay; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000517:prevention & control* / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000517:prevention & control* / Q000523:psychology*; D011446:Prospective Studies; D011788:Quality of Life; D012121:Respiration, Artificial
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein