title: Ultraviolet or blue-filtering intraocular lenses: what is the evidence?
abstract: Cataract surgery was revolutionised by the introduction of modern intraocular lenses in the late 1940's. By the late 1960's to 1970's evidence had emerged that short-wavelength light caused phototoxicity at the retina and retinal pigment epithelium. By the early 1980's ultraviolet filters had been incorporated into intraocular lenses. This caused intense controversy, as there was concern that the UV-filtering chromophore might leach out into the eye causing toxicity. With the arrival of blue-filtering intraocular lenses (BFIOLs) in 1990's, a further debate was ignited as to their safety and potential disadvantages. Selecting the optimal performing intraocular lens to obtain the best visual performance with the fewest potential drawbacks has become complex and challenging for cataract surgeons and their patients with the wide choice of lenses available. Choosing a personalised lens to address astigmatism, presbyopia, spherical aberration, chromatic aberration, and potentially to shield the retina from short-wavelength light is now possible. The potential benefits and possible side effects of these different innovations emphasise the importance of assessing the evidence for their clinical utility, allowing the surgeon and the patient to weigh-up the risk benefit ratio and make an informed decision. The BFIOLs were developed to reduce cyanopsia, address chromatic aberration, and improve contrast sensitivity in different lighting conditions, as well as to prevent short-wavelength light reaching the retina thus potentially reducing the risk of developing age-related macular degeneration. Further design development of the BFIOLs was to mimic the natural crystalline lens absorption and transmittance properties in adulthood. Multiple publications have reported on the potential benefits and pitfalls of implanting a blue-filtering lens. The potential disadvantages raised in the literature over the last 25 years since their introduction, regarding compromise of visual function and disruption of the circadian system, have been largely dispelled. The clear benefits of protecting the retina from short-wavelength light make a BFIOLs a sensible choice. The purpose of this article presented at the Cambridge symposium 2015 is to review the literature on this subject.
authors.affiliation: Oxford Eye Hospital, Oxford University Hospitals Foundation Trust, and Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, UK.
authors.forename: S M
authors.initials: SM
authors.lastname: Downes
mesh_terms: D002387:Cataract Extraction; D020099:Coated Materials, Biocompatible; D005374:Filtration / Q000295:instrumentation*; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D011474:Prosthesis Design; D011832:Radiation Injuries / Q000517:prevention & control; D011835:Radiation Protection / Q000295:instrumentation*; D014466:Ultraviolet Rays; D014786:Vision Disorders / Q000517:prevention & control
chemical_list: D020099:Coated Materials, Biocompatible