title: Inhibition of epidermal growth factor receptor induces tumor necrosis factor-α via activation of peroxisome proliferator-activated receptor-γ and nuclear factor-κB in sebocytes: A possible pathogenesis of papulopustular rash.
authors.affiliation: Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ashida
authors.affiliation: Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Eisaku
authors.initials: E
authors.lastname: Ogawa
authors.affiliation: Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Uhara
authors.affiliation: Comprehensive Cancer Center, Shinshu University Hospital, Matsumoto, Japan.
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.affiliation: Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan. Electronic address: rokuyama@shinshu-u.ac.jp.
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Okuyama
mesh_terms: D002460:Cell Line; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000069347:Erlotinib Hydrochloride / Q000633:toxicity*; D000077156:Gefitinib; D006801:Humans; D016328:NF-kappa B / Q000819:agonists* / Q000378:metabolism; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000633:toxicity*; D011799:Quinazolines / Q000633:toxicity*; D012627:Sebaceous Glands / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D016328:NF-kappa B; D047495:PPAR gamma; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D014409:Tumor Necrosis Factor-alpha; D000069347:Erlotinib Hydrochloride; C512478:EGFR protein, human; D066246:ErbB Receptors; D000077156:Gefitinib
keywords: Differentiation; EGFR inhibitor; NF-κB; PPARγ; Papulopustular rash; TNFα