title: Investigation of Risk Factors, Stage and Outcome in Patients with Gestational Trophoblastic Disease since 2001 to 2011 in Iran-Yazd.
abstract: OBJECTIVE
  Gestational trophoblastic disease (GTN) is one of the high-risk forms of pregnancy that requires a lot of attention in terms of research studies, considering its incidence and the importance of the disease in advanced form. The aim of this study was to investigate the risk factors and clinical procedure of patients with gestational trophoblastic disease from 2001 to 2002.
  
  
  METHODS
  This is a retrospective descriptive study, which was carried out on 150 patients with trophoblastic disease. These patients' files were obtained from Shohadaye Kargar and Shahid Sadoughi hospitals and women's oncology offices of Yazd city. The patients were contacted one by one and their disease situation was determined. The data obtained were recorded in a questionnaire and analyzed by SPSS software.
  
  
  RESULTS
  The results indicated that the average age of the patients was 27.65 ± 8.22 with variations in age ranging from 15 to 35 year. In addition, majorities were in the age group of 20 to 40 years. 43.2 percent of the women were affected during their first gestation. 4% had molar gestation record, and 9.4% had positive family record. Mean time of survival was 93.38 ± 0.62 months (MIN ± SE), and only one died owing to chemotherapy complication. Vaginal bleeding (90%) was the most common symptom. 54.6 percent of the disease had complete mole, 30% had incomplete mole, 8.6% had invasive mole, 4.6% had choriocarcinoma and 2% had placenta site trophoblastic tumor (PSTT). Among the patients studied, 28.7% were benign in GTN group while 71.3 % were malignant in the GTN group. The malignant patients were divided into three groups per risk, and 41.2% were in the high-risk group. There was theca-lutein cyst in 54% of the patients, which had a significant relationship with the disease risk of persistent GTN.
  
  
  CONCLUSIONS
  Choriocarcinoma and invasive mole is the most malignant pathology. There was significant relationship between disease interval and the beginning of chemotherapy, and theca lutein cyst and persistent GTN.
authors.affiliation: Associated professor, Department of Gynecology Oncology, Clinical Research Development, Shahid Sadoughi University of Medical Science, Yazd, Iran;
authors.forename: Mojgan
authors.initials: M
authors.lastname: Karimi-Zarchi
authors.affiliation: Assistant professor, Hematology and oncology, hematology and oncology department, Islamic Azad University, Yazd branch, Iran;
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Mortazavizadeh
authors.affiliation: General physician;
authors.forename: Malihe
authors.initials: M
authors.lastname: Soltani-Gerdefaramrzi
authors.affiliation: Medical Student, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;
authors.forename: Mitra
authors.initials: M
authors.lastname: Rouhi
authors.affiliation: Student of medicine, Scientific society of medicine, Yazd branch, Islamic Azad University, Yazd, Iran.
authors.forename: Pouria
authors.initials: P
authors.lastname: Yazdian-Anari
authors.affiliation: Epidemiologist, Shahid Sadoughi University of Medical Science, Yazd, Iran.
authors.forename: Mohammad Hosain
authors.initials: MH
authors.lastname: Ahmadiyeh
keywords: Gestational Trophoblastic Disease; Outcome; Risk Factors; Stage of Disease