title: Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng.
abstract: Four new fungal polyketides named koninginins N-Q (1-4), together with four known analogues (5-8), were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH30002 harbored in Panax notoginseng. Their structures were determined on the basis of spectral data interpretation. These compounds were evaluated for their antifungal activity, nitric oxide inhibition, and anticoagulant activity.
authors.affiliation: Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
authors.forename: Ya-Bin
authors.initials: YB
authors.lastname: Yang
authors.affiliation: School of Energy and Environment Science, Yunnan Normal University, Kunming, 650092, People's Republic of China.
authors.forename: Jin-Lian
authors.initials: JL
authors.lastname: Chen
authors.affiliation: Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, People's Republic of China.
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Miao
authors.affiliation: Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, People's Republic of China.
authors.forename: You-Wei
authors.initials: YW
authors.lastname: Chen
authors.affiliation: Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, People's Republic of China.
authors.forename: Yi-Qing
authors.initials: YQ
authors.lastname: Li
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. ztding@ynu.edu.cn.
authors.forename: Zhong-Tao
authors.initials: ZT
authors.lastname: Ding
authors.affiliation: Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, People's Republic of China. zlx70@163.com.
authors.forename: Li-Xing
authors.initials: LX
authors.lastname: Zhao
keywords: Antifungal activity; Bioactivity assay; Koninginin; Polyketide; Trichoderma koningiopsis