title: Alzheimer's Model Develops Early ADHD Syndrome.
abstract: We describe the first invertebrate model of attention deficit hyperactivity disorder (ADHD) that reproduces its major features, including hyperactivity, male predominance, marked exacerbation by simple carbohydrates, reversible response to dextroamphetamine, and a "paradoxical response" to stimulants. This model may offer new insight into ADHD pathogenesis and treatment. Furthermore, these findings are of particular interest in light of the recent epidemiological evidence showing that patients with dementia have a high frequency of antecedent ADHD symptoms.
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA.
authors.forename: Guiping
authors.initials: G
authors.lastname: Du
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA ; Drug Discovery Lab, Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: V
authors.initials: V
authors.lastname: John
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Kapahi
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA ; Department of Neurology, University of California, Los Angeles, CA 90095.
authors.forename: Dale E
authors.initials: DE
authors.lastname: Bredesen
keywords: ADHD; Alzheimer’s disease; AβPP; Drosophila