title: Association of Tumor Growth Factor-β and Interferon-γ Serum Levels With Insulin Resistance in Normal Pregnancy.
abstract: Pregnancy is related to change in glucose metabolism and insulin production. The aim of our study was to determine the association of serum IFN-γ and TGF- β levels with insulin resistance during normal pregnancy. This cross sectional study was carried out on 97 healthy pregnant (in different trimesters) and 28 healthy non-pregnant women. Serum TGF-β and IFN- γ level were measured by ELISA method. Pregnant women had high level TGF-β and low level IFN-γ as compared non-pregnant women. Maternal serum TGF-β concentration significantly increased in third trimester as compared first and second trimester of pregnancy. Maternal serum IFN-γ concentration significantly decreased in third trimester as compared first and second trimester of pregnancy. Pregnant women exhibited higher score of HOMA IR as compared non-pregnant women. There were association between gestational age with body mass index (r=0.28, P=0.005), TGF-β (r=0.45, P<0.001) and IFN-γ (r=-0.50, P<0.001). There was significant association between Insulin resistance and TGF-β (r=0.17, p=0.05). Our findings suggest that changes in maternal cytokine level in healthy pregnant women were anti-inflammatory. Furthermore, Tumor Growth Factor-β appears has a role in induction insulin resistance in healthy pregnant women. However, further studies needed to evaluate role of different cytokines on insulin resistance in normal pregnancy.
authors.affiliation: Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran. sotoodehj2002@yahoo.com.
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Sotoodeh Jahromi
authors.forename: Mohammad Sadegh
authors.initials: MS
authors.lastname: Sanie
authors.forename: Alireza
authors.initials: A
authors.lastname: Yusefi
authors.forename: Hassan
authors.initials: H
authors.lastname: Zabetian
authors.forename: Parvin
authors.initials: P
authors.lastname: Zareian
authors.forename: Hossein
authors.initials: H
authors.lastname: Hakimelahi
authors.forename: Abdolhossien
authors.initials: A
authors.lastname: Madani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hojjat-Farsangi
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007371:Interferon-gamma / Q000097:blood*; D011247:Pregnancy; D016212:Transforming Growth Factor beta / Q000097:blood*
chemical_list: D016212:Transforming Growth Factor beta; D007371:Interferon-gamma