title: Bioactive Polycyclic Quinones from Marine Streptomyces sp. 182SMLY.
abstract: Chemical investigation of the cultures of marine Streptomyces sp. 182SMLY led to the discovery of two new polycyclic anthraquinones, which were elucidated as N-acetyl-N-demethylmayamycin (1) and streptoanthraquinone A (2) based on the extensive spectroscopic analysis including 2D NMR, HRESIMS, and an electronic circular dichroism (ECD) calculation. Both anthraquinones remarkably suppressed the proliferation of four different glioma cell lines with IC50 values in a range from 0.5 to 7.3 μM and induced apoptosis in the glioma cells. The ratios of IC50 for normal human astrocytes to IC50 for glioma cells were 6.4-53 for 1 and >14-31 for 2. N-acetyl-N-demethylmayamycin (1) also inhibited the growth of methicillin-resistant Staphylococcus aureus with MIC 20.0 μM.
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China. lynne3665@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. 21319046@zju.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Xie
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China. chenlu0310@sina.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China. slyanphd@163.com.
authors.forename: Shilun
authors.initials: S
authors.lastname: Yan
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China. moshangmowei@163.com.
authors.forename: Xuewei
authors.initials: X
authors.lastname: Ye
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China. komalazam@ymail.com.
authors.forename: Komal
authors.initials: K
authors.lastname: Anjum
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China. hchuang@zju.edu.cn.
authors.forename: Haocai
authors.initials: H
authors.lastname: Huang
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. xylian@zju.edu.cn.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Lian
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China. zzhang88@zju.edu.cn.
authors.forename: Zhizhen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D002681:China; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D011809:Quinones / Q000494:pharmacology*; D051381:Rats; D012623:Seawater; D013211:Staphylococcus aureus / Q000187:drug effects*; D013302:Streptomyces / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D011809:Quinones
keywords: N-acetyl-N-demethylmayamycin; bioactivities against glioma cells and bacteria; marine bacterium Streptomyces sp. 182SMLY; streptoanthraquinone A