title: Pulmonary Fissure Detection in CT Images Using a Derivative of Stick Filter.
abstract: Pulmonary fissures are important landmarks for recognition of lung anatomy. In CT images, automatic detection of fissures is complicated by factors like intensity variability, pathological deformation and imaging noise. To circumvent this problem, we propose a derivative of stick (DoS) filter for fissure enhancement and a post-processing pipeline for subsequent segmentation. Considering a typical thin curvilinear shape of fissure profiles inside 2D cross-sections, the DoS filter is presented by first defining nonlinear derivatives along a triple stick kernel in varying directions. Then, to accommodate pathological abnormality and orientational deviation, a [Formula: see text] cascading and multiple plane integration scheme is adopted to form a shape-tuned likelihood for 3D surface patches discrimination. During the post-processing stage, our main contribution is to isolate the fissure patches from adhering clutters by introducing a branch-point removal algorithm, and a multi-threshold merging framework is employed to compensate for local intensity inhomogeneity. The performance of our method was validated in experiments with two clinical CT data sets including 55 publicly available LOLA11 scans as well as separate left and right lung images from 23 GLUCOLD scans of COPD patients. Compared with manually delineating interlobar boundary references, our method obtained a high segmentation accuracy with median F1-scores of 0.833, 0.885, and 0.856 for the LOLA11, left and right lung images respectively, whereas the corresponding indices for a conventional Wiemker filtering method were 0.687, 0.853, and 0.841. The good performance of our proposed method was also verified by visual inspection and demonstration on abnormal and pathological cases, where typical deformations were robustly detected together with normal fissures.
authors.forename: Changyan
authors.initials: C
authors.lastname: Xiao
authors.forename: Berend C
authors.initials: BC
authors.lastname: Stoel
authors.forename: M Els
authors.initials: ME
authors.lastname: Bakker
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Peng
authors.forename: Jan
authors.initials: J
authors.lastname: Stolk
authors.forename: Marius
authors.initials: M
authors.lastname: Staring
mesh_terms: D000368:Aged; D000465:Algorithms; D059925:Anatomic Landmarks / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D016208:Databases, Factual; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive; D014057:Tomography, X-Ray Computed / Q000379:methods*