title: Apolipoprotein E ɛ2/ɛ3/ɛ4 variant in association with obstructive sleep apnoea and lipid profile: A meta-analysis.
abstract: OBJECTIVE
  A meta-analysis of the association between haplotypical variants of the apolipoprotein E (APOE) gene (ɛ2/ɛ3/ɛ4) and obstructive sleep apnoea (OSA) risk and changes in lipid profile.
  
  
  METHODS
  Electronic databases were searched to retrieve articles that provided data on APOE gene ɛ2/ɛ3/ɛ4 variants in patients with OSA and healthy controls. Data were extracted from eligible articles and statistical analyses were performed.
  
  
  RESULTS
  The meta-analysis included 14 articles involving 19 study populations (3198 patients and 6031 controls). There was no significant association between the presence of the ɛ4 allele and OSA risk. The presence of ɛ4 was associated with significantly increased total cholesterol and decreased high-density lipoprotein cholesterol, compared with ɛ4 allele negative individuals. There was a low probability of publication bias but significant heterogeneity.
  
  
  CONCLUSIONS
  There was no association between APOE ɛ2/ɛ3/ɛ4 and OSA susceptibility. The presence of APOE ɛ4 was associated with changes in lipid profile.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China luzq109@126.com.
authors.forename: Zhuoqiang
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Internal Medicine, Fuzhou Children's Hospital of Fujian Province, Teaching Hospital of Fujian Medical University, Fuzhou, Fujian, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Internal Medicine (Area 4), The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Peng
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
authors.forename: Jinxiu
authors.initials: J
authors.lastname: Lin
mesh_terms: D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D015992:Body Mass Index; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008055:Lipids / Q000097:blood*; D012044:Regression Analysis; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D008055:Lipids
keywords: Obstructive sleep apnoea; apolipoprotein E; meta-analysis; variant