title: Rhodamine analogues for molecular ruler applications.
abstract: A series of geometrically well-defined cationic fluorophores were designed based on molecular mechanics. They contain biaryl linkers to impart rigidity preventing intramolecular folding between a conjugated biomolecule and fluorophore. All probes have absorption and emission maxima within 20 nm from Texas Red, as predicted by TDDFT calculations and validated experimentally.
authors.affiliation: Department of Chemistry, Portland State University, Portland, Oregon 97207, USA.
authors.forename: Yu-Hsuan
authors.initials: YH
authors.lastname: Chu
authors.affiliation: Department of Chemistry, Portland State University, Portland, Oregon 97207, USA.
authors.forename: Jorge O
authors.initials: JO
authors.lastname: Escobedo
authors.affiliation: Oregon Hearing Research Center, Oregon Health & Science University, Portland, Oregon, USA.
authors.forename: Meiyan
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Oregon Hearing Research Center, Oregon Health & Science University, Portland, Oregon, USA.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Steyger
authors.affiliation: Department of Chemistry, Portland State University, Portland, Oregon 97207, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Strongin
keywords: ion channel; molecular ruler; pore dilation; rhodamine