title: Spontaneous Regression of Intravascular Large B-Cell Lymphoma and Apoptosis of Lymphoma Cells: A Case Report.
abstract: A 61-year-old Japanese woman presented with hemophagocytic syndrome (HPS) and suffered from intravascular large B-cell lymphoma (IVLBCL). After a few days of supportive care, her condition improved without any anti-cancer drugs or steroids. She experienced recurrences of HPS at 15 mon and 21 mon after first presentation, but lymphoma cells were not observed. Relapse of IVLBCL with pulmonary involvement occurred 27 mon after first presentation. She underwent R-CHOP therapy followed by autologous stem cell transplantation. She is currently alive and without lymphoma. Immunostaining by anti-ssDNA suggested that spontaneous regression may have been due to apoptosis of the lymphoma cells.
authors.affiliation: Department of Oncology/Hematology, Shimane　University Hospital.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Ikejiri
authors.forename: Saki
authors.initials: S
authors.lastname: Takami
authors.forename: Takahiro
authors.initials: T
authors.lastname: Okada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kumanomidou
authors.forename: Koji
authors.initials: K
authors.lastname: Adachi
authors.forename: Jo
authors.initials: J
authors.lastname: Yumi
authors.forename: Chie
authors.initials: C
authors.lastname: Onishi
authors.forename: Koshi
authors.initials: K
authors.lastname: Kawakami
authors.forename: Ichiro
authors.initials: I
authors.lastname: Moriyama
authors.forename: Masaya
authors.initials: M
authors.lastname: Inoue
authors.forename: Takaaki
authors.initials: T
authors.lastname: Miyake
authors.forename: Junko
authors.initials: J
authors.lastname: Tanaka
authors.forename: Riruke
authors.initials: R
authors.lastname: Maruyama
authors.forename: Junji
authors.initials: J
authors.lastname: Suzumiya
mesh_terms: D017209:Apoptosis; D015415:Biomarkers; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous
chemical_list: D015415:Biomarkers