title: miR-503 inhibits cell proliferation and invasion in glioma by targeting L1CAM.
abstract: Deregulated microRNAs and their roles in tumorigenesis have attracted much attention in recent years. Although miR-503 has been reported to be aberrant expression in several cancers, its role in glioma remains unknown. In this study, we focused on the expression and mechanisms of miR-503 in glioma development. We found that miR-503 was downregulated in glioma cell lines and tumor tissues, and the restoration of miR-503 reduced cell proliferation invasion. Furthermore, bioinformatics analysis indicated that L1CAM was a putative target of miR-503. In a Luciferase reporter system, we confirmed that L1CAM was a direct target gene of miR-503. These findings indicate that miR-503 suppresses glioma cell growth by negatively regulating the expression of L1CAM. Collectively, our data identify the important roles of miR-503 in glioma pathogenesis, indicating its potential application in cancer therapy.
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Neurology, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P. R. China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P. R. China.
authors.forename: Daguang
authors.initials: D
authors.lastname: Liao
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P. R. China.
authors.forename: Tianyi
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Neurology, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P. R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P. R. China.
authors.forename: Kui
authors.initials: K
authors.lastname: Luo
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P. R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Yang
keywords: L1CAM; glioma; invasion; miR-503; proliferation