title: Catalytic asymmetric [3 + 2]-cycloaddition for stereodivergent synthesis of chiral indolyl-pyrrolidines.
abstract: The stereochemical divergent synthesis of indolyl-pyrrolidines was accomplished using an imidazoline-aminophenol (IAP)-Ni(OAc)2 complex and a bis(imidazolidine)pyridine (PyBidine)-Cu(OTf)2 complex. The former catalyzed exo'-selective asymmetric [3 + 2] cyclization of iminoesters with indolyl nitroalkenes, and the latter catalyzed the reaction in an endo-selective manner. These catalysts are tolerant toward highly functional substrates that supply chiral indolyl-pyrrolidine hybrids.
authors.affiliation: Molecular Chirality Research Center, and Department of Chemistry, Graduate School of Science, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan. tarai@faculty.chiba-u.jp.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Arai
authors.affiliation: Molecular Chirality Research Center, and Department of Chemistry, Graduate School of Science, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan. tarai@faculty.chiba-u.jp.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Tokumitsu
authors.affiliation: Molecular Chirality Research Center, and Department of Chemistry, Graduate School of Science, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan. tarai@faculty.chiba-u.jp.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Miyazaki
authors.affiliation: Molecular Chirality Research Center, and Department of Chemistry, Graduate School of Science, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan. tarai@faculty.chiba-u.jp.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kuwano
authors.affiliation: Molecular Chirality Research Center, and Department of Chemistry, Graduate School of Science, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan. tarai@faculty.chiba-u.jp.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Awata