title: Recent Strategies in Tissue Engineering for Guided Peripheral Nerve Regeneration.
abstract: The repair of large crushed or sectioned segments of peripheral nerves remains a challenge in regenerative medicine due to the complexity of the biological environment and the lack of proper biomaterials and architecture to foster reconstruction. Traditionally such reconstruction is only achieved by using fresh human tissue as a surrogate for the absence of the nerve. However, recent focus in the field has been on new polymer structures and specific biofunctionalization to achieve the goal of peripheral nerve regeneration by developing artificial nerve prostheses. This review presents various tested approaches as well their effectiveness for nerve regrowth and functional recovery.
authors.affiliation: Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de Recherches Royallieu - CS 60 3019, 60203, Compiègne cedex, France.
authors.forename: Kayla
authors.initials: K
authors.lastname: Belanger
authors.affiliation: Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de Recherches Royallieu - CS 60 3019, 60203, Compiègne cedex, France.
authors.forename: Tony M
authors.initials: TM
authors.lastname: Dinis
authors.affiliation: Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de Recherches Royallieu - CS 60 3019, 60203, Compiègne cedex, France.
authors.forename: Sami
authors.initials: S
authors.lastname: Taourirt
authors.affiliation: Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de Recherches Royallieu - CS 60 3019, 60203, Compiègne cedex, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vidal
authors.affiliation: Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA, 02155, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Kaplan
authors.affiliation: Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de Recherches Royallieu - CS 60 3019, 60203, Compiègne cedex, France.|Department of Oral and Maxillofacial Pathology, Tufts University, School of Dental Medicine, 55 Kneeland Street, Boston, MA, 02111, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Egles
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D003094:Collagen / Q000737:chemistry / Q000494:pharmacology; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D009414:Nerve Growth Factors / Q000494:pharmacology; D009416:Nerve Regeneration / Q000502:physiology; D059348:Peripheral Nerve Injuries / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D010525:Peripheral Nerves / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D016378:Tissue Transplantation / Q000379:methods; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D001672:Biocompatible Materials; D009414:Nerve Growth Factors; D011108:Polymers; D003094:Collagen; D048271:Chitosan
keywords: bioengineering; biomaterials; peripheral nervous system; polymers; regenerative medicine