title: [Squamous cell carcinoma, basaloid squamous cell carcinoma and adenosquamous carcinoma in the lung].
abstract: The precise distinction between adenocarcinoma and squamous cell carcinoma (SqCC) has become very important for determining the appropriate therapy for patients and more specifically to drive the use of tyrosine kinase inhibitors, pemetrexed, anti-VEGF monoclonal antibody and crizotinib. Squamous pearls and distinct intercellular bridges identify keratinizing SqCC. In non-keratinizing SqCC, immuno-histochemistry is required. Recent studies have shown p40 and TTF1 to be the two best markers of SqCC and adenocarcinoma respectively. Many morphological variants of SqCC have been described. Basaloid SqCC is a poorly differentiated epithelial tumor lacking squamous morphology but showing immuno-histochemical expression of squamous makers. The pronostic of basaloid carcinoma is considered poorer than that of other non-small cell lung cancers. Adenosquamous carcinoma shows components of both SqCC and adenocarcinoma. Both components must be clearly identified either on H&E or by immuno-histochemistry. The adenocarcinoma components justified a screening for gene rearrangements. Finally, the recent WHO classification of lung tumors did not change the criteria applying for the grading of preinvasive bronchial lesion.
authors.affiliation: Département de pathologie, CHRU de Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny-Co n(o) 34, 54035 Nancy cedex, France. Electronic address: jm.vignaud@chu-nancy.fr.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Vignaud
mesh_terms: D014408:Biomarkers, Tumor; D002278:Carcinoma in Situ / Q000737:chemistry / Q000473:pathology; D018196:Carcinoma, Adenosquamous / Q000737:chemistry / Q000145:classification* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000145:classification* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000032:analysis; D006801:Humans; D008171:Lung Diseases / Q000473:pathology; D008175:Lung Neoplasms / Q000737:chemistry / Q000145:classification* / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology; D014157:Transcription Factors / Q000032:analysis; D025521:Tumor Suppressor Proteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C115051:TP63 protein, human; C504003:TTF1 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins
keywords: Adenosquamous carcinoma; Basaloid squamous cell carcinoma; Carcinoma in situ; Carcinome adénosquameux; Carcinome basaloïde; Carcinome in situ; Carcinome épidermoïde; Dysplasie malpighienne; Squamous cell carcinoma; Squamous dysplasia; TTF1; p40