title: Diagnosis and neurocognitive profiles in first-episode non-affective psychosis patients.
abstract: This study explored whether there are distinguishable neurocognitive profiles in diagnostic subgroups of first-episode non-affective psychosis (FEP) patients. Four hundred and eighty-seven individuals with diagnoses of non-affective psychosis disorders were evaluated 6 months after first contact with psychiatric services. Individuals with schizophrenia (n = 257), schizophreniform (n = 141), brief psychotic disorder (n = 54), and psychosis not otherwise specified (n = 35) were compared on baseline neuropsychological variables using analyses of variance and covariance with potential clinical, premorbid, and sociodemographic confounders. The brief psychotic disorder subgroup was the least impaired on global cognitive function, in particular when compared to the schizophrenia subgroup, and specifically on executive function, processing speed, and motor dexterity domains. However, with the exception of the processing speed domain, profile differences could be explained by sex, age, psychotic and negative symptoms, years of education, and premorbid IQ. These results suggest processing speed as a diagnostic marker for brief psychotic disorder in FEP patients. Further, there are quantitative and qualitative differences across the schizophrenia spectrum disorders subgroups, indicating different profiles with varying degrees of deficit.
authors.affiliation: Department of Psychiatry, IDIVAL, School of Medicine, Marqués de Valdecilla University Hospital, University of Cantabria, Avda. Valdecilla s/n, 39008, Santander, Spain. rayesa@humv.es.|CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain. rayesa@humv.es.
authors.forename: Rosa
authors.initials: R
authors.lastname: Ayesa-Arriola
authors.affiliation: Department of Psychiatry, IDIVAL, School of Medicine, Marqués de Valdecilla University Hospital, University of Cantabria, Avda. Valdecilla s/n, 39008, Santander, Spain.|CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez-Sánchez
authors.affiliation: Department of Psychiatry, IDIVAL, School of Medicine, Marqués de Valdecilla University Hospital, University of Cantabria, Avda. Valdecilla s/n, 39008, Santander, Spain.
authors.forename: Esther Setién
authors.initials: ES
authors.lastname: Suero
authors.affiliation: Department of Psychology, Temple University, Philadelphia, PA, USA.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Reeves
authors.affiliation: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain.|Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Valencia, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Tabarés-Seisdedos
authors.affiliation: Department of Psychiatry, IDIVAL, School of Medicine, Marqués de Valdecilla University Hospital, University of Cantabria, Avda. Valdecilla s/n, 39008, Santander, Spain.|CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain.
authors.forename: Benedicto
authors.initials: B
authors.lastname: Crespo-Facorro
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*; D011618:Psychotic Disorders / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D055815:Young Adult
keywords: Diagnosis; First-episode psychosis; Neurocognition; Schizophrenia