title: Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin.
abstract: Self-assembled metallocages are very promising drug-delivery systems among supramolecular complexes. Thus, exo-functionalized Pd2 L4 (L=ligand) cages were synthesized and characterized, and the encapsulation of the anticancer drug cisplatin in their cavity has been documented. The antiproliferative effects of the metallocages and their combination with cisplatin were examined in vitro in cancer cell lines, while fluorescence microscopy was used to monitor their uptake. Notably, the hydroxymethyl-functionalized Pd(II) cage encapsulating cisplatin showed improved cytotoxic effect against human ovarian cancer cells compared to free cisplatin. The toxicity of Pd2 L4 cages was evaluated for the first time ex vivo in healthy rat-liver tissues using the precision cut-tissue slices technology, demonstrating in some cases scarce effects on liver viability. These results further highlight the potential of self-assembled Pd2 L4 cages for biological applications.
authors.affiliation: Department of Chemistry, Catalysis Research Center, Technische Universität München, Lichtenbergstrasse 4, 85747, Garching, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Schmidt
authors.affiliation: Dept. of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713, AV Groningen, The Netherlands.
authors.forename: Viviana
authors.initials: V
authors.lastname: Molano
authors.affiliation: Department of Chemistry, Catalysis Research Center, Technische Universität München, Lichtenbergstrasse 4, 85747, Garching, Germany.
authors.forename: Manuela
authors.initials: M
authors.lastname: Hollering
authors.affiliation: Department of Chemistry, Catalysis Research Center, Technische Universität München, Lichtenbergstrasse 4, 85747, Garching, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Pöthig
authors.affiliation: Dept. of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713, AV Groningen, The Netherlands. casinia@cardiff.ac.uk.|School of Chemistry, Cardiff University, Park Place, CF103AT, Cardiff, UK. casinia@cardiff.ac.uk.
authors.forename: Angela
authors.initials: A
authors.lastname: Casini
authors.affiliation: Department of Chemistry, Catalysis Research Center, Technische Universität München, Lichtenbergstrasse 4, 85747, Garching, Germany. fritz.kuehn@ch.tum.de.
authors.forename: Fritz E
authors.initials: FE
authors.lastname: Kühn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001686:Biological Phenomena; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000737:chemistry* / Q000494:pharmacology*; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry*; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D009944:Organoplatinum Compounds; D010165:Palladium; D002945:Cisplatin
keywords: cisplatin; drug delivery; metallocages; palladium; self-assembly