title: Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study.
abstract: OBJECTIVE
  The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2).
  
  
  METHODS
  Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20% Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained.
  
  
  RESULTS
  Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min(-1)); 18.5 ± 1.5 (5 L min(-1)); 21.7 ± 1.7 (10 L min(-1)); 24.0 ± 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air.
  
  
  CONCLUSIONS
  An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.
authors.affiliation: Subdivision MOVEFIT-Sports Medicine, Department of Rehabilitation Medicine, Erasmus University Medical Center, Wytemaweg 80, 3000 CA, Rotterdam, The Netherlands. r.rozenberg@erasmusmc.nl.
authors.forename: Robert
authors.initials: R
authors.lastname: Rozenberg
authors.affiliation: Subdivision MOVEFIT-Sports Medicine, Department of Rehabilitation Medicine, Erasmus University Medical Center, Wytemaweg 80, 3000 CA, Rotterdam, The Netherlands. r.mankowski@ufl.edu.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Mankowski
authors.affiliation: Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands. l.vanloon@maastrichtuniversity.nl.
authors.forename: Luc J C
authors.initials: LJ
authors.lastname: van Loon
authors.affiliation: Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. j.langendonk@erasmusmc.nl.
authors.forename: Janneke G
authors.initials: JG
authors.lastname: Langendonk
authors.affiliation: Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. e.sijbrands@erasmusmc.nl.
authors.forename: Eric J G
authors.initials: EJ
authors.lastname: Sijbrands
authors.affiliation: Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. a.vandenmeiracker@erasmusmc.nl.
authors.forename: Anton H
authors.initials: AH
authors.lastname: van den Meiracker
authors.affiliation: Subdivision MOVEFIT-Sports Medicine, Department of Rehabilitation Medicine, Erasmus University Medical Center, Wytemaweg 80, 3000 CA, Rotterdam, The Netherlands. h.j.stam@erasmusmc.nl.
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Stam
authors.affiliation: Subdivision MOVEFIT-Sports Medicine, Department of Rehabilitation Medicine, Erasmus University Medical Center, Wytemaweg 80, 3000 CA, Rotterdam, The Netherlands. s.praet@erasmusmc.nl.
authors.forename: Stephan F E
authors.initials: SF
authors.lastname: Praet
mesh_terms: D000704:Analysis of Variance; D001784:Blood Gas Analysis; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005240:Feasibility Studies; D006339:Heart Rate; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018496:Hyperoxia; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D011312:Pressure
chemical_list: D010100:Oxygen