title: Chemistry of Ketene N,S-Acetals: An Overview.
abstract: Push-pull alkenes, which bear electron-donating and -accepting group(s) at both termini of a C═C double bond, respectively, are of interest not only for their unique electronic properties but also for their importance as versatile building blocks in organic synthesis. In the world of ketene acetals having the push-pull alkene skeleton, ketene N,S-acetal is most likely the biggest family according to the number and types of these compounds. The first ketene N,S-acetal compound was reported in 1956. As a cyclic ketene N,S-acetal compound, nithiazine, the first lead structure of neonicotinoid insecticides, was reported in 1978. The characteristics of ketene N,S-acetals, which have the structural feature of ketene S,S-acetals and enaminones, make them versatile and easy to use, especially in cyclization and multicomponent reactions for the synthesis of various heterocyclic systems and related natural products. There has been an increasing wealth of information about the synthesis and synthetic applications of ketene N,S-acetals, especially, in recent years. This review provides comprehensive knowledge on the chemistry of ketene N,S-acetals.
authors.affiliation: Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors.forename: Jinhuan
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors.forename: Xianxiu
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu