title: Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines.
abstract: Type 2 diabetes mellitus (T2DM) is recognized as major risk factor for the progress of active pulmonary tuberculosis (PTB), although the mechanistic link between diabetes and tuberculosis remains poorly characterized. Moreover, the influence of poorly controlled diabetes on the baseline levels of adipocytokines in the context of tuberculosis has not been explored in detail. To characterize the influence of coexistent DM on adipocytokine levels in pulmonary or latent TB (LTB), we examined circulating levels of adipocytokines in the plasma of individuals with PTB-DM or LTB-DM and compared them with those without DM (PTB or LTB). PTB-DM or LTB-DM is characterized by diminished circulating levels of adiponectin and adipsin and/or heightened circulating levels of leptin, visfatin and PAI-1. In addition, adiponectin and adipsin exhibit a significant negative correlation, whereas leptin, visfatin and PAI-1 display a significant positive correlation with HbA1C levels and random blood glucose levels. Therefore, our data reveal that PTB-DM or LTB-DM is characterized by alterations in the systemic levels of adipocytokines, indicating that altered adipose tissue inflammation underlying Type 2 diabetes potentially contributes to pathogenesis of TB disease.
authors.affiliation: National Institutes of Health-International Center for Excellence in Research, Chennai, India; National Institute for Research in Tuberculosis, Chennai, India. Electronic address: pavankumarn@nirt.res.in.
authors.forename: Nathella
authors.initials: N
authors.lastname: Pavan Kumar
authors.affiliation: National Institute for Research in Tuberculosis, Chennai, India.
authors.forename: Dina
authors.initials: D
authors.lastname: Nair
authors.affiliation: National Institute for Research in Tuberculosis, Chennai, India.
authors.forename: V V
authors.initials: VV
authors.lastname: Banurekha
authors.affiliation: National Institute for Research in Tuberculosis, Chennai, India.
authors.forename: Chandrakumar
authors.initials: C
authors.lastname: Dolla
authors.affiliation: National Institute for Research in Tuberculosis, Chennai, India.
authors.forename: Paul
authors.initials: P
authors.lastname: Kumaran
authors.affiliation: Government Stanley Medical Hospital, Chennai, India.
authors.forename: Rathinam
authors.initials: R
authors.lastname: Sridhar
authors.affiliation: National Institutes of Health-International Center for Excellence in Research, Chennai, India.
authors.forename: Subash
authors.initials: S
authors.lastname: Babu
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D011416:Complement Factor D / Q000378:metabolism; D016207:Cytokines / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000473:pathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000473:pathology; D055985:Latent Tuberculosis / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000382:microbiology / Q000473:pathology*
chemical_list: D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; D011416:Complement Factor D; D016207:Cytokines; D006442:Glycated Hemoglobin; D020738:Leptin; D054409:Nicotinamide Phosphoribosyltransferase; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; C517652:hemoglobin A1c protein, human; C085455:nicotinamide phosphoribosyltransferase, human
keywords: Adipocytokines; Diabetes mellitus; Immune regulation; Immune response; Mycobacterium tuberculosis