title: Effect of chirality in gamma-PNA: PNA interaction, another piece in the picture.
abstract: Modification of the PNA backbone can be used to broaden their utility by introducing new functional groups. In particular, gamma-modified PNA have been found to be quite effective in a number of applications, and exhibit particularly high DNA binding affinity. The introduction of one side chain imply that the achiral backbone of PNA becomes chiral, and binding properties depend on the stereochemistry. A new paper on gamma-modified PNA by Ly and co-workers complete the existing knowledge by displaying that in binding to complementary PNA stereochemical orthogonality can be demonstrated. This opens the way to the exploitation of stereochemical features in diagnostic assays and in nanofabrication.
authors.affiliation: a Dipartimento di Chimica; University of Parma; Parma , Italy.
authors.forename: Alex
authors.initials: A
authors.lastname: Manicardi
authors.affiliation: a Dipartimento di Chimica; University of Parma; Parma , Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Corradini
mesh_terms: D004247:DNA / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004268:DNA-Binding Proteins; D020135:Peptide Nucleic Acids; D004247:DNA
keywords: gamma-PNA; nanofabrication; orthogonality; self-assembly; stereochemistry