title: Renal Blood Oxygenation Level-dependent Imaging in Longitudinal Follow-up of Donated and Remaining Kidneys.
abstract: Purpose To determine renal oxygenation changes associated with uninephrectomy and transplantation in both native donor kidneys and transplanted kidneys by using blood oxygenation level-dependent (BOLD) MR imaging. Materials and Methods The study protocol was approved by the local ethics committee. Thirteen healthy kidney donors and their corresponding recipients underwent kidney BOLD MR imaging with a 3-T imager. Written informed consent was obtained from each subject. BOLD MR imaging was performed in donors before uninephrectomy and in donors and recipients 8 days, 3 months, and 12 months after transplantation. R2* values, which are inversely related to tissue partial pressure of oxygen, were determined in the cortex and medulla. Longitudinal R2* changes were statistically analyzed by using repeated measures one-way analysis of variance with post hoc pair-wise comparisons. Results R2* values in the remaining kidneys significantly decreased early after uninephrectomy in both the medulla and cortex (P < .003), from 28.9 sec(-1) ± 2.3 to 26.4 sec(-1) ± 2.5 in the medulla and from 18.3 sec(-1) ± 1.5 to 16.3 sec(-1) ± 1.0 in the cortex, indicating increased oxygen content. In donors, R2* remained significantly decreased in both the medulla and cortex at 3 (P < .01) and 12 (P < .01) months. In transplanted kidneys, R2* remained stable during the first year after transplantation, with no significant change. Among donors, cortical R2* was found to be negatively correlated with estimated glomerular filtration rate (R = -0.47, P < .001). Conclusion The results suggest that BOLD MR imaging may potentially be used to monitor renal functional changes in both remaining and corresponding transplanted kidneys. (©) RSNA, 2016.
authors.affiliation: From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiology, Neuroradiology and Nuclear Medicine (H.C.T.) and Department of Nephrology, Hypertension and Clinical Pharmacology (B.V.), University Hospital of Bern, Switzerland.
authors.forename: Maryam
authors.initials: M
authors.lastname: Seif
authors.affiliation: From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiology, Neuroradiology and Nuclear Medicine (H.C.T.) and Department of Nephrology, Hypertension and Clinical Pharmacology (B.V.), University Hospital of Bern, Switzerland.
authors.forename: Ute
authors.initials: U
authors.lastname: Eisenberger
authors.affiliation: From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiology, Neuroradiology and Nuclear Medicine (H.C.T.) and Department of Nephrology, Hypertension and Clinical Pharmacology (B.V.), University Hospital of Bern, Switzerland.
authors.forename: Tobias
authors.initials: T
authors.lastname: Binser
authors.affiliation: From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiology, Neuroradiology and Nuclear Medicine (H.C.T.) and Department of Nephrology, Hypertension and Clinical Pharmacology (B.V.), University Hospital of Bern, Switzerland.
authors.forename: Harriet C
authors.initials: HC
authors.lastname: Thoeny
authors.affiliation: From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiology, Neuroradiology and Nuclear Medicine (H.C.T.) and Department of Nephrology, Hypertension and Clinical Pharmacology (B.V.), University Hospital of Bern, Switzerland.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Krauer
authors.affiliation: From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiology, Neuroradiology and Nuclear Medicine (H.C.T.) and Department of Nephrology, Hypertension and Clinical Pharmacology (B.V.), University Hospital of Bern, Switzerland.
authors.forename: Aurelia
authors.initials: A
authors.lastname: Rusch
authors.affiliation: From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiology, Neuroradiology and Nuclear Medicine (H.C.T.) and Department of Nephrology, Hypertension and Clinical Pharmacology (B.V.), University Hospital of Bern, Switzerland.
authors.forename: Chris
authors.initials: C
authors.lastname: Boesch
authors.affiliation: From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiology, Neuroradiology and Nuclear Medicine (H.C.T.) and Department of Nephrology, Hypertension and Clinical Pharmacology (B.V.), University Hospital of Bern, Switzerland.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vogt
authors.affiliation: From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiology, Neuroradiology and Nuclear Medicine (H.C.T.) and Department of Nephrology, Hypertension and Clinical Pharmacology (B.V.), University Hospital of Bern, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Vermathen
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging; D016030:Kidney Transplantation; D019520:Living Donors; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D009929:Organ Size; D010100:Oxygen / Q000097:blood*; D014019:Tissue Donors
chemical_list: D010100:Oxygen