title: Perisurgical and intra-rehabilitative salivary steroid hormone profiles in bicompartmental arthroplasty.
abstract: Sex hormones play a role in pain perception, a key variable in evaluating the progression and treatment of osteoarthritis. The aim of this study was to determine the relationship between salivary concentrations of four steroid hormones and functional/clinical outcomes after hip and knee arthroplasty. Saliva samples were collected from 24 otherwise healthy patients with osteoarthritis before surgery, on admission to rehabilitation, and at hospital discharge. Salivary concentrations of testosterone, 17β-estradiol, dehydroepiandrosterone (DHEA), and cortisol were immunoassayed. Changes in hormone levels were compared with clinical outcomes, as assessed by functional independence measure (FIM®), Barthel Index (BI), and visual analog scale for pain (VAS) scores. Changes in testosterone levels were significantly inversely correlated with VAS (r= -0.53, p=0.043) and FIM® and BI scores in all patients (r= -0.30, p= 0.043, and r= -0.35, p=0.031, respectively). The testosterone to cortisol ratio was inversely correlated with BI scores in all patients (r= -0.30, p=0.040), and in the men (r= -0.55, p=0.005) and the women (r= -0.28, p=0.042) when analyzed separately. Changes in salivary testosterone concentrations closely correlated with clinical outcome measurements for total hip and knee arthroplasty. Clinical outcome after arthroplasty was generally better among the men.
authors.affiliation: Laboratory of Experimental Biochemistry and Molecular Biology, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Perego
authors.affiliation: Laboratory of Experimental Biochemistry and Molecular Biology, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milan, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Grasso
authors.affiliation: O.U. Rehabilitation, 1st Division  Clinical Orthopaedic Rehabilitation, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milan, Italy.
authors.forename: B D
authors.initials: BD
authors.lastname: Bodini
authors.affiliation: O.U. Rehabilitation, 1st Division  Clinical Orthopaedic Rehabilitation, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cavaiani
authors.affiliation: O.U. Rehabilitation, 1st Division  Clinical Orthopaedic Rehabilitation, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: De Santis
authors.affiliation: O.U. Reconstructive Joint Surgery and Orthopaedic Surgery (C.A.S.C.O.), I.R.C.C.S. Istituto Ortopedico Galeazzi, Milan, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Ursino
authors.affiliation: O.U. Rehabilitation, 1st Division  Clinical Orthopaedic Rehabilitation, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pelosi
authors.affiliation: Laboratory of Experimental Biochemistry and Molecular Biology, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Banfi
authors.affiliation: Laboratory of Experimental Biochemistry and Molecular Biology, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D003687:Dehydroepiandrosterone / Q000032:analysis; D004958:Estradiol / Q000032:analysis; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry*; D013256:Steroids / Q000032:analysis*; D013739:Testosterone / Q000032:analysis; D064232:Visual Analog Scale
chemical_list: D013256:Steroids; D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol; D006854:Hydrocortisone