title: Cyanobacterial Metabolite Calothrixins: Recent Advances in Synthesis and Biological Evaluation.
abstract: The marine environment is host to unparalleled biological and chemical diversity, making it an attractive resource for the discovery of new therapeutics for a plethora of diseases. Compounds that are extracted from cyanobacteria are of special interest due to their unique structural scaffolds and capacity to produce potent pharmaceutical and biotechnological traits. Calothrixins A and B are two cyanobacterial metabolites with a structural assembly of quinoline, quinone, and indole pharmacophores. This review surveys recent advances in the synthesis and evaluation of the biological activities of calothrixins. Due to the low isolation yields from the marine source and the promise this scaffold holds for anticancer and antimicrobial drugs, organic and medicinal chemists around the world have embarked on developing efficient synthetic routes to produce calothrixins. Since the first review appeared in 2009, 11 novel syntheses of calothrixins have been published in the efforts to develop methods that contain fewer steps and higher-yielding reactions. Calothrixins have shown their potential as topoisomerase I poisons for their cytotoxicity in cancer. They have also been observed to target various aspects of RNA synthesis in bacteria. Further investigation into the exact mechanism for their bioactivity is still required for many of its analogs.
authors.affiliation: Department of Chemistry, University of Alabama at Birmingham, 901, 14th Street South, Birmingham, AL 35294-1240, USA. suxu@uab.edu.
authors.forename: Su
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Chemistry, University of Alabama at Birmingham, 901, 14th Street South, Birmingham, AL 35294-1240, USA. snij@uab.edu.
authors.forename: Bhavitavya
authors.initials: B
authors.lastname: Nijampatnam
authors.affiliation: Department of Chemistry, University of Alabama at Birmingham, 901, 14th Street South, Birmingham, AL 35294-1240, USA. shilpad@uab.edu.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Dutta
authors.affiliation: Department of Chemistry, University of Alabama at Birmingham, 901, 14th Street South, Birmingham, AL 35294-1240, USA. svelu@uab.edu.
authors.forename: Sadanandan E
authors.initials: SE
authors.lastname: Velu
mesh_terms: D000458:Cyanobacteria; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D012623:Seawater
chemical_list: D026121:Indole Alkaloids; C418328:calothrixin A; C418327:calothrixin B
keywords: anticancer activity; antimicrobial activity; calothrix; calothrixin; cyanobacteria; marine natural product; total synthesis