title: Dietary phosphorus restriction in predialysis chronic kidney disease: time for a cease-fire?
abstract: The increased awareness that disorders of phosphorus metabolism occur early in the course of chronic kidney disease fuels interest in early intervention strategies. A post hoc analysis of data from the Modification of Diet in Renal Disease (MDRD) Study questions the clinical relevance of early dietary phosphate restriction, so far considered a mainstay in the prevention and treatment of mineral metabolism disorders. Still, on the basis of available evidence, a cease-fire in the war on dietary phosphate would be premature.
authors.affiliation: Department of Immunology and Microbiology, Laboratory of Nephrology, Katholieke Universiteit Leuven, Leuven, Belgium. Electronic address: Pieter.Evenepoel@uzleuven.be.
authors.forename: Pieter
authors.initials: P
authors.lastname: Evenepoel
authors.affiliation: Department of Nephrology and Institute for Cardiovascular Research VU, VU University Medical Center Amsterdam, Amsterdam, the Netherlands.
authors.forename: Marc G
authors.initials: MG
authors.lastname: Vervloet
mesh_terms: D004032:Diet; D006801:Humans; D007676:Kidney Failure, Chronic; D010710:Phosphates / Q000378:metabolism; D010758:Phosphorus; D016226:Phosphorus, Dietary / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic
chemical_list: D010710:Phosphates; D016226:Phosphorus, Dietary; D010758:Phosphorus