title: Advancing translational research with next-generation protein microarrays.
abstract: Protein microarrays are a high-throughput technology used increasingly in translational research, seeking to apply basic science findings to enhance human health. In addition to assessing protein levels, posttranslational modifications, and signaling pathways in patient samples, protein microarrays have aided in the identification of potential protein biomarkers of disease and infection. In this perspective, the different types of full-length protein microarrays that are used in translational research are reviewed. Specific studies employing these microarrays are presented to highlight their potential in finding solutions to real clinical problems. Finally, the criteria that should be considered when developing next-generation protein microarrays are provided.
authors.affiliation: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (The PHOENIX Center, Beijing), Beijing, P. R. China.|The Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Yu
authors.affiliation: The Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
authors.forename: Brianne
authors.initials: B
authors.lastname: Petritis
authors.affiliation: The Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: LaBaer
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D003141:Communicable Diseases / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism; D040081:Protein Array Analysis / Q000379:methods*; D011485:Protein Binding; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D057170:Translational Research, Biomedical / Q000379:methods*
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: Biomarker; In vitro diagnostics; Protein microarray; Translational research