title: Autophagy Snuffs a Macrophage's Inner Fire.
abstract: Autophagy is a well-known cell-intrinsic antiviral defense mechanism. Two new studies published in this issue of Cell Host & Microbe (Lu et al., 2016; Park et al., 2016) demonstrate that deletion of autophagy in myeloid cells leads paradoxically to better control of viral infection in vivo through enhanced inflammation, leading to antiviral resistance.
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: William
authors.initials: W
authors.lastname: Khoury-Hanold
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: akiko.iwasaki@yale.edu.
authors.forename: Akiko
authors.initials: A
authors.lastname: Iwasaki
mesh_terms: D001343:Autophagy; D007249:Inflammation; D008264:Macrophages; D022423:Myeloid Cells