title: Effects of vascular endothelial growth factor-b on the bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching.
abstract: Using a microelectrode technique we studied the effects of vascular endothelial growth factor-B on the activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that vascular endothelial growth factor-B increased duration of the action potential only at the level of 90&#x0025; re-polarization. Effects on the frequency and force of contraction were absent. The repetition frequency of the action potentials did not change. Close observation of the vascular endothelial growth factor-B-induced mechanisms and stretch-induced alteration in action potential durations to 90% of repolarization, confirmed the existence of a link between the examining growth factor-B and stretch induced mechanisms.
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Moscow, Russia.
authors.forename: R S
authors.initials: RS
authors.lastname: Ovchinnikov
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Moscow, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Mitrokhin
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Moscow, Russia.
authors.forename: M I
authors.initials: MI
authors.lastname: Mladenov
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D006325:Heart Atria / Q000187:drug effects*; D008297:Male; D008839:Microelectrodes; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D042561:Vascular Endothelial Growth Factor B / Q000494:pharmacology*
chemical_list: D042561:Vascular Endothelial Growth Factor B