title: Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil.
abstract: OBJECTIVE
  To present the frequency of single nucleotide polymorphisms of a few immune response genes in a population sample from São Paulo City (SP), Brazil.
  
  
  METHODS
  Data on allele frequencies of known polymorphisms of innate and acquired immunity genes were presented, the majority with proven impact on gene function. Data were gathered from a sample of healthy individuals, non-HLA identical siblings of bone marrow transplant recipients from the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, obtained between 1998 and 2005. The number of samples varied for each single nucleotide polymorphism analyzed by polymerase chain reaction followed by restriction enzyme cleavage.
  
  
  RESULTS
  Allele and genotype distribution of 41 different gene polymorphisms, mostly cytokines, but also including other immune response genes, were presented.
  
  
  CONCLUSIONS
  We believe that the data presented here can be of great value for case-control studies, to define which polymorphisms are present in biologically relevant frequencies and to assess targets for therapeutic intervention in polygenic diseases with a component of immune and inflammatory responses.
authors.affiliation: Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo - USP, São Paulo, SP, BR.
authors.forename: Léa Campos de
authors.initials: LC
authors.lastname: Oliveira
authors.affiliation: Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo - USP, São Paulo, SP, BR.
authors.forename: Rajendranath
authors.initials: R
authors.lastname: Ramasawmy
authors.affiliation: Instituto Israelita de Ensino e Pesquisa Albert Einstein - IIEPAE, São Paulo, SP, BR.
authors.forename: Jaila Dias
authors.initials: JD
authors.lastname: Borges
authors.affiliation: Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo - USP, São Paulo, SP, BR.
authors.forename: Maria Lucia Carnevale
authors.initials: ML
authors.lastname: Marin
authors.affiliation: Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo - USP, São Paulo, SP, BR.
authors.forename: Natalie Guida
authors.initials: NG
authors.lastname: Muller
authors.affiliation: Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo - USP, São Paulo, SP, BR.
authors.forename: Jorge
authors.initials: J
authors.lastname: Kalil
authors.affiliation: Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo - USP, São Paulo, SP, BR.
authors.forename: Anna Carla
authors.initials: AC
authors.lastname: Goldberg