title: Multicenter Comparison of Machine Learning Methods and Conventional Regression for Predicting Clinical Deterioration on the Wards.
abstract: OBJECTIVE
  Machine learning methods are flexible prediction algorithms that may be more accurate than conventional regression. We compared the accuracy of different techniques for detecting clinical deterioration on the wards in a large, multicenter database.
  
  
  METHODS
  Observational cohort study.
  
  
  METHODS
  Five hospitals, from November 2008 until January 2013.
  
  
  METHODS
  Hospitalized ward patients
  
  
  METHODS
  None
  
  
  RESULTS
  Demographic variables, laboratory values, and vital signs were utilized in a discrete-time survival analysis framework to predict the combined outcome of cardiac arrest, intensive care unit transfer, or death. Two logistic regression models (one using linear predictor terms and a second utilizing restricted cubic splines) were compared to several different machine learning methods. The models were derived in the first 60% of the data by date and then validated in the next 40%. For model derivation, each event time window was matched to a non-event window. All models were compared to each other and to the Modified Early Warning score, a commonly cited early warning score, using the area under the receiver operating characteristic curve (AUC). A total of 269,999 patients were admitted, and 424 cardiac arrests, 13,188 intensive care unit transfers, and 2,840 deaths occurred in the study. In the validation dataset, the random forest model was the most accurate model (AUC, 0.80 [95% CI, 0.80-0.80]). The logistic regression model with spline predictors was more accurate than the model utilizing linear predictors (AUC, 0.77 vs 0.74; p < 0.01), and all models were more accurate than the MEWS (AUC, 0.70 [95% CI, 0.70-0.70]).
  
  
  CONCLUSIONS
  In this multicenter study, we found that several machine learning methods more accurately predicted clinical deterioration than logistic regression. Use of detection algorithms derived from these techniques may result in improved identification of critically ill patients on the wards.
authors.affiliation: 1Department of Medicine, University of Chicago, Chicago, IL. 2Department of Medicine, NorthShore University HealthSystem, Evanston, IL. 3Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Churpek
authors.forename: Trevor C
authors.initials: TC
authors.lastname: Yuen
authors.forename: Christopher
authors.initials: C
authors.lastname: Winslow
authors.forename: David O
authors.initials: DO
authors.lastname: Meltzer
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kattan
authors.forename: Dana P
authors.initials: DP
authors.lastname: Edelson
mesh_terms: D000367:Age Factors; D015331:Cohort Studies; D019937:Diagnostic Techniques and Procedures; D006323:Heart Arrest / Q000401:mortality*; D006801:Humans; D007362:Intensive Care Units / Q000458:organization & administration*; D016015:Logistic Models; D000069550:Machine Learning / Q000706:statistics & numerical data*; D015233:Models, Statistical; D016571:Neural Networks, Computer; D012372:ROC Curve; D018570:Risk Assessment; D012959:Socioeconomic Factors; D060388:Support Vector Machine; D016019:Survival Analysis; D013997:Time Factors; D055986:Vital Signs