title: Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art.
abstract: Inflammatory diseases are considered to be highly dreadful ones responsible for higher mortality in the developed countries. This includes cancer, psoriasis, rheumatoid arthritis, and inflammatory bowel disease. The tremendous strides in the area of drug development to find newer molecules like non-steroidal and steroidal agents and immunosuppressant agents delivered by conventional formulation. These therapy have enhances the life expectancy of patient, but it provide the therapeutic benefits only to a limited extent. Recent advancement in liposomes based nanomedicines has led to the possibility of improves the efficacy and safety of the pharmacotherapy of inflammatory disorders. Of late, liposomes have been highly explored as one of the promising systems for delivering numerous anti-inflammatory drugs for attaining enhanced therapeutic outcomes. Over the conventional carriers, liposomal systems have numerous drug delivery merits including advantages in both passive and active targeting of drug molecules to the inflammatory lesions. The current review article, therefore, endeavors to provide a bird's eye view account on the success of liposome-based therapeutic systems in the management of dreadful inflammatory disorders along with updated knowledge to pharmaceutical scientists in the field.
authors.affiliation: a Department of Pharmaceutical Sciences , Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences (SHIATS) , Allahabad , India ;
authors.forename: Mahfoozur
authors.initials: M
authors.lastname: Rahman
authors.affiliation: a Department of Pharmaceutical Sciences , Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences (SHIATS) , Allahabad , India ;
authors.forename: Vikas
authors.initials: V
authors.lastname: Kumar
authors.affiliation: b Department of Pharmaceutics , Faculty of Pharmacy, Jamia Hamdard , New Delhi , India ;
authors.forename: Sarwar
authors.initials: S
authors.lastname: Beg
authors.affiliation: c Liposome Research Laboratory, UIPS, Panjab University , Chandigarh , Mumbai , India ;
authors.forename: Gajanand
authors.initials: G
authors.lastname: Sharma
authors.affiliation: c Liposome Research Laboratory, UIPS, Panjab University , Chandigarh , Mumbai , India ;
authors.forename: Om Prakash
authors.initials: OP
authors.lastname: Katare
authors.affiliation: d Department of Biochemistry , Faculty of Science, King Abdulaziz University , Jeddah , Kingdom of Saudi Arabia.
authors.forename: Firoz
authors.initials: F
authors.lastname: Anwar
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D007249:Inflammation / Q000188:drug therapy; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D008081:Liposomes / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D008081:Liposomes
keywords: Cancer; cationic liposomes; inflammatory disorders; liposomes; psoriasis; rheumatoid arthritis