title: Tirofiban as treatment for acute retinal artery occlusion following internal carotid artery flow diverter implantation.
abstract: OBJECTIVE
  To report a favorable outcome of branch retinal artery occlusion (BRAO) treated by means of early administration of tirofiban, a glycoprotein IIb-IIIa platelet receptor inhibitor.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 65-year-old woman developed dramatic visual impairment in her left eye secondary to BRAO after left internal carotid artery endovascular reconstruction with flow diverter stent implant; visual acuity was hand motion. A dose of intravenous tirofiban was injected 10 minutes after symptoms onset. Fourteen hours after drug infusion, retinal fluorescein angiography revealed a well-perfused macula with a partial reperfusion of the inferior temporal branch of the central retinal artery; visual acuity was 20/20 in both eyes.
  
  
  CONCLUSIONS
  This case supports the effectiveness of tirofiban in secondary BRAO in neurosurgery and may open its usage to further research.
authors.affiliation: Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Pierro
authors.affiliation: Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: La Spina
authors.affiliation: Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Corvi
authors.affiliation: Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Cicinelli
authors.affiliation: Department of Neuroradiology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Scomazzoni
authors.affiliation: Department of Cardiology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Cappelletti
authors.affiliation: Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan - Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Bandello
mesh_terms: D000208:Acute Disease; D000368:Aged; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D002343:Carotid Artery, Internal; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D015356:Retinal Artery Occlusion / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D015607:Stents / Q000009:adverse effects*; D000077466:Tirofiban; D041623:Tomography, Optical Coherence; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014792:Visual Acuity
chemical_list: D010975:Platelet Aggregation Inhibitors; D014443:Tyrosine; D000077466:Tirofiban