title: Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia.
abstract: OBJECTIVE
  To analyze the outcome of patients treated with gemtuzumab ozogamycin combined with conventional therapy treated at Hospital Israelita Albert Einstein.
  
  
  METHODS
  14 patients who had high risk features (secondary leukemia, unfavorable cytogenetics, and refractory disease) were treated with gemtuzumab ozogamycin combined with conventional therapy and their outcome was analysed by reviewing their medical records.
  
  
  RESULTS
  Overall response rate was 58%, with 43% achieving complete response, with a median follow-up of 11 months, event-free survival was 3 months. Eleven patients died, 6 of them due to refractory acute myeloid leukemia. Only four patients presented with grade 3 to 4 toxicities and only one patient had sinusoidal obstruction syndrome after bone marrow transplant.
  
  
  CONCLUSIONS
  gemtuzumab ozogamycin combined with chemotherapy is a feasible treatment regimen in acute myeloid leukemia patients. However, further studies are necessary to clarify which subgroup of patients may beneft from this treatment.
authors.affiliation: Hospital Israelita Albert Einstein - HIAE, São Paulo, SP, BR.
authors.forename: Guilherme Fleury
authors.initials: GF
authors.lastname: Perini
authors.affiliation: Hospital Israelita Albert Einstein - HIAE, São Paulo, SP, BR.
authors.forename: Fabio Pires de Souza
authors.initials: FP
authors.lastname: Santos
authors.affiliation: Hospital Israelita Albert Einstein - HIAE, São Paulo, SP, BR.
authors.forename: Iracema
authors.initials: I
authors.lastname: Esteves
authors.affiliation: Hospital Israelita Albert Einstein - HIAE, São Paulo, SP, BR.
authors.forename: Claudia Mac-Donald Bley do
authors.initials: CM
authors.lastname: Nascimento
authors.affiliation: Hospital Israelita Albert Einstein - HIAE, São Paulo, SP, BR.
authors.forename: Morgani
authors.initials: M
authors.lastname: Rodrigues
authors.affiliation: Hospital Israelita Albert Einstein - HIAE, São Paulo, SP, BR.
authors.forename: Reijane Alves de
authors.initials: RA
authors.lastname: Assis
authors.affiliation: Hospital Israelita Albert Einstein - HIAE, São Paulo, SP, BR.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Helman
authors.affiliation: Hospital Isrealita Albert Einstein - HIAE, São Paulo, SP, BR.
authors.forename: Jose Mauro
authors.initials: JM
authors.lastname: Kutner
authors.affiliation: Hospital Isrealita Albert Einstein - HIAE, São Paulo, SP, BR.
authors.forename: Andreza Alice Feitosa
authors.initials: AA
authors.lastname: Ribeiro
authors.affiliation: Hospital Israelita Albert Einstein - HIAE, São Paulo, SP, BR.
authors.forename: Nelson
authors.initials: N
authors.lastname: Hamerschlak