title: Expression and clinical significance of P53, O6-methylguanine-dna methyltransferase and epidermal growth factor receptor in glioma.
abstract: Glioma is a serious life-threatening disease, the pathogenesis of which remains to be investigated. The objective of the present investigation was to explore the expression and clinical significance of tumor suppressor gene (P53), O6-methylguanine-DNA methyltransferase (MGMT) and epidermal growth factor receptor (EGFR) in glioma. Immunohistochemical staining was applied to study the clinical characteristics of 40 samples from glioma patients, detect the expression of and analyse the relationship between P53, MGMT and EGFR and glioma. The results demonstrated that the positive expression rate of P53 was 47.5% in 40 cases of glioma samples, of which the expression of P53 in the high grade glioma was higher than that of the low grade samples (P < 0.05); the positive expression rate of MGMT was 37.5%, but there was no significant significance of MGMT expression between the high grade glioma and the low grade glioma (P >0.05); the positive expression rate of EGFR was 55%, of which the expression of EGFR of the high grade glioma was higher than that of the low grade glioma (P<0.05). There was no significant difference in the expressions of P53, MGMT and EGFR in the glioma patients of different ages, gender and with different tumor sizes. The expressions of P53 and MGMT were negatively correlated (P<0.05). The expressions of P53 and EGFR were positively correlated (P<0.05). In conclusion, P53, EGFR and MGMT could play a role in the occurrence, development and deterioration of glioma.
authors.affiliation: Oncology Department, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: X R
authors.initials: XR
authors.lastname: Fu
authors.affiliation: Oncology Department, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Z C
authors.initials: ZC
authors.lastname: Sun
authors.affiliation: Oncology Department, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000737:chemistry / Q000209:etiology / Q000473:pathology*; D002648:Child; D015254:DNA Modification Methylases / Q000032:analysis / Q000502:physiology*; D045643:DNA Repair Enzymes / Q000032:analysis / Q000502:physiology*; D066246:ErbB Receptors / Q000032:analysis / Q000502:physiology*; D005260:Female; D005910:Glioma / Q000737:chemistry / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000032:analysis / Q000502:physiology*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; C512478:EGFR protein, human; D066246:ErbB Receptors; D045643:DNA Repair Enzymes