title: Tumor homing indocyanine green encapsulated micelles for near infrared and photoacoustic imaging of tumors.
abstract: Photoacoustic imaging (PAI) is an emerging analytical modality that is under intense preclinical development for the early diagnosis of various medical conditions, including cancer. However, the lack of specific tumor targeting by various contrast agents used in PAI obstructs its clinical applications. In this study, we developed indocyanine green (ICG)-encapsulated micelles specific for the CD 44 receptor and used in near infrared and photoacoustic imaging of tumors. ICG was hydrophobically modified prior to loading into hyaluronic acid (HA)-based micelles utilized for CD 44 based-targeting. We investigated the physicochemical characteristics of prepared HA only and ICG-encapsulated HA micelles (HA-ICG micelles). After intravenous injection of tumor-bearing mice, the bio-distribution and in vivo photoacoustic images of ICG-encapsulated HA micelles accumulating in tumors were also investigated. Our study further encourages the application of this HA-ICG-based nano-platform as a tumor-specific contrast agent for PAI.
authors.affiliation: Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Saji
authors.initials: S
authors.lastname: Uthaman
authors.affiliation: Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Joon-suk
authors.initials: JS
authors.lastname: Bom
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Hyeon Sik
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Polymer Science and Engineering, BK 21 PLUS Center for Advanced Chemical Technology, Pusan National University, Pusan 609-735, Republic of Korea.
authors.forename: Johnson V
authors.initials: JV
authors.lastname: John
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Hee-Seung
authors.initials: HS
authors.lastname: Bom
authors.affiliation: Department of Korean Medicine Rehabilitation, Mokpo Oriental Hospital of Dongshin University, 313 Baengnyeon-daero, Mokpo 530-822, Korea.
authors.forename: Seon-Jong
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Jung-Joon
authors.initials: JJ
authors.lastname: Min
authors.affiliation: Department of Polymer Science and Engineering, BK 21 PLUS Center for Advanced Chemical Technology, Pusan National University, Pusan 609-735, Republic of Korea.
authors.forename: Il
authors.initials: I
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: In-Kyu
authors.initials: IK
authors.lastname: Park
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D064593:Heterografts; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D008823:Micelles; D041681:NIH 3T3 Cells; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging*; D061088:Photoacoustic Techniques / Q000379:methods*
chemical_list: D004337:Drug Carriers; D008823:Micelles; D007208:Indocyanine Green
keywords: CD44 receptor; hyaluronic acid; indocyanine green; near infrared imaging; photoacoustic imaging