title: miRNAs Regulation and Its Role as Biomarkers in Endometriosis.
abstract: MicroRNAs (miRNAs) are small non-coding RNAs (18-22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease.
authors.affiliation: Unit of Hemostasia, Thrombosis, Atherosclerosis and Vascular Biology, Health Research Institute La Fe, Valencia 46026, Spain. josepmarialexandre@gmail.com.
authors.forename: Josep
authors.initials: J
authors.lastname: Marí-Alexandre
authors.affiliation: Arrays Unit, Health Research Institute La Fe, Valencia 46026, Spain. Maria.D.Sanchez@uv.es.
authors.forename: Dolors
authors.initials: D
authors.lastname: Sánchez-Izquierdo
authors.affiliation: Maternal Child Area, General Hospital, Valencia 46014, Spain. juangilaeste@yahoo.es.
authors.forename: Juan
authors.initials: J
authors.lastname: Gilabert-Estellés
authors.affiliation: Unit of Hemostasia, Thrombosis, Atherosclerosis and Vascular Biology, Health Research Institute La Fe, Valencia 46026, Spain. moibarcelo@live.com.
authors.forename: Moisés
authors.initials: M
authors.lastname: Barceló-Molina
authors.affiliation: Unit of Hemostasia, Thrombosis, Atherosclerosis and Vascular Biology, Health Research Institute La Fe, Valencia 46026, Spain. a.braza.boils@gmail.com.
authors.forename: Aitana
authors.initials: A
authors.lastname: Braza-Boïls
authors.affiliation: Epigomics Unit, Health Research Institute La Fe, Valencia 46026, Spain. juan.sandoval@uv.es.
authors.forename: Juan
authors.initials: J
authors.lastname: Sandoval
mesh_terms: D015415:Biomarkers / Q000097:blood; D004715:Endometriosis / Q000097:blood* / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D012333:RNA, Messenger / Q000097:blood / Q000235:genetics; D020733:RNA, Small Cytoplasmic / Q000097:blood / Q000235:genetics; D034741:RNA, Small Interfering / Q000097:blood / Q000235:genetics; D012343:RNA, Transfer / Q000097:blood / Q000235:genetics
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D012333:RNA, Messenger; D020733:RNA, Small Cytoplasmic; D034741:RNA, Small Interfering; D012343:RNA, Transfer
keywords: biomarker; endometriosis; microRNA; non-coding RNA