title: TRPA1 channels as targets for resveratrol and related stilbenoids.
abstract: A series of twenty resveratrol analogues was synthesized and tested on TRPA1 and TRPV1 channels. None was able to significantly modulate TRPV1 channels. Conversely, most of them exhibited remarkably higher TRPA1 modulating activity than resveratrol. Optimal potency was observed with ortho monoxygenated stilbenes 6 and 17.
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, piazzale Aldo Moro 5, 00185 Roma, Italy. Electronic address: marianna.nalli@uniroma1.it.
authors.forename: Marianna
authors.initials: M
authors.lastname: Nalli
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, piazzale Aldo Moro 5, 00185 Roma, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ortar
authors.affiliation: Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, via dei Campi Flegrei 34, 80078 Pozzuoli (Napoli), Italy.
authors.forename: Aniello Schiano
authors.initials: AS
authors.lastname: Moriello
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, piazzale Aldo Moro 5, 00185 Roma, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Morera
authors.affiliation: Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, via dei Campi Flegrei 34, 80078 Pozzuoli (Napoli), Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Marzo
authors.affiliation: Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, via dei Campi Flegrei 34, 80078 Pozzuoli (Napoli), Italy. Electronic address: l.depetrocellis@icb.cnr.it.
authors.forename: Luciano
authors.initials: L
authors.lastname: De Petrocellis
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D057809:HEK293 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D017136:Ion Transport / Q000187:drug effects; D011485:Protein Binding; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D013267:Stilbenes; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels; C480976:Trpa1 protein, rat; D000077185:Resveratrol; D002118:Calcium
keywords: Resveratrol; Stilbenoids; TRP channels; TRPA1; TRPV1