title: Recombinant immune complexes as versatile and potent vaccines.
abstract: Immune complexes (IC) used as vaccines have the potential to enhance both antibody and cell-mediated immune responses over those obtained with antigen alone. However, difficulty of manufacture represents a significant hurdle to the widespread use of IC as vaccines. Recombinant IC (RIC) and their expression in plants enable manufacturing by the coordinate expression of immunoglobulin and antigen as a fusion protein. The use of a modular RIC system facilitates insertion of antigen genes and provides a broadly applicable platform that can be adapted for a wide variety of antigens.
authors.affiliation: a Biodesign Institute and School of Life Sciences, Arizona State University , Tempe , AZ , USA.
authors.forename: Hugh S
authors.initials: HS
authors.lastname: Mason
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000936:Antigen-Antibody Complex / Q000008:administration & dosage / Q000009:adverse effects / Q000235:genetics* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000276:immunology; D064166:Vaccine Potency; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D000936:Antigen-Antibody Complex; D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic
keywords: antibody fusion; immune complex; recombinant plant; transient expression; vaccine