title: Current status of Clonorchis sinensis and clonorchiasis in China.
abstract: The oriental liver fluke, Clonorchis sinensis, a pathogen causing clonorchiasis, is of major socio-economic importance in East Asia, including China, Korea and Vietnam. This parasite is now recognized as a biocarcinogen strongly linked to cholangiocarcinoma in humans. Here, we describe the status of clonorchiasis in China, where it has been estimated that more than 15 million patients are affected. This paper also summarizes the major advances in the field of clonorchiasis research during last decade, including diagnosis techniques, pathogenesis and genome/transcriptome/proteome studies in the last years. We strongly hope that our work can stimulate the governments of the countries or regions where clonorchiasis is endemic to pay more attention to this disease and establish related guidelines to prevent and control it.
authors.affiliation: Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China laidehua@mail.sysu.edu.cn.
authors.forename: De-Hua
authors.initials: DH
authors.lastname: Lai
authors.affiliation: Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China.
authors.forename: Xiao-Kun
authors.initials: XK
authors.lastname: Hong
authors.affiliation: Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China.
authors.forename: Bi-Xiu
authors.initials: BX
authors.lastname: Su
authors.affiliation: Key Laboratory of Tropical Diseases and Control of the Ministry of Education, Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510275, PR China.
authors.forename: Chi
authors.initials: C
authors.lastname: Liang
authors.affiliation: Ecosystems and Environment and Biomedical Research Centres, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, UK.
authors.forename: Geoff
authors.initials: G
authors.lastname: Hide
authors.affiliation: Department of Parasitology, Harbin Medical University, Harbin 150081, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Tropical Diseases and Control of the Ministry of Education, Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510275, PR China.
authors.forename: Xinbing
authors.initials: X
authors.lastname: Yu
authors.affiliation: Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China Key Laboratory of Tropical Diseases and Control of the Ministry of Education, Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510275, PR China Ecosystems and Environment and Biomedical Research Centres, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, UK.
authors.forename: Zhao-Rong
authors.initials: ZR
authors.lastname: Lun
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D003003:Clonorchiasis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D003004:Clonorchis sinensis / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D018509:DNA, Helminth / Q000032:analysis; D014644:Genetic Variation; D006790:Host-Parasite Interactions / Q000502:physiology; D006801:Humans; D008018:Life Cycle Stages
chemical_list: D000871:Anthelmintics; D018509:DNA, Helminth
keywords: Biocarcinogen; China; Cholangiocarcinoma; Foodborne parasite; Hepatobiliary related disease; Neglected tropical disease