title: Expression of MAGE-A1, -A9, -A11 in laryngeal squamous cell carcinoma and their prognostic significance: a retrospective clinical study.
abstract: CONCLUSIONS
  The melanoma-associated antigens A1, -A9, -A11 (MAGE-A1, -A9, -A11) are relatively tumor-specific in laryngeal squamous cell carcinoma (LSCC), and could be ideal antigens for LSCC immunotherapy. In addition, MAGE-A9 probably is a poor prognostic marker for LSCC patients.
  
  
  OBJECTIVE
  The MAGE-A family belongs to Cancer/testis antigens (CTA). However, the expression pattern of MAGE-A1, MAGE-A9, and MAGE-A11 in LSCC is still unclear. This study aims to evaluate the expression and possible prognostic role of MAGE-A1, MAGE-A9, and MAGE-A11 in LSCC patients.
  
  
  METHODS
  The expression of MAGE-A1, MAGE-A9, and MAGE-A11 in LSCC specimens was investigated by immunohistochemistry, and the association of their expression and the clinical parameters and the survival of LSCC patients were analyzed by chi-square test, Kaplan-Meier survival and Cox regression analysis.
  
  
  RESULTS
  The expression rates of MAGE-A1, MAGE-A9, and MAGE-A11 in LSCC were 54.7%, 46.2%, and 51.9%, respectively. The expression of MAGE-A1, MAGE-A9, and MAGE-A11 in LSCC was correlated with clinical stage, lymph node metastasis, and tumor size. The overall survival of LSCC patients with positive MAGE-A1, MAGE-A9, or MAGE-A11 expression was lower than the patients without MAGE-A1, MAGE-A9, or MAGE-A11 expression. Cox's multivariable analysis showed that MAGE-A9 expression was an independently poor prognostic factor for LSCC patients.
authors.affiliation: a Research Center, the Fourth Hospital of Hebei Medical University , Shijiazhuang , Hebei , PR China ;|b Department of Otolaryngology , the Fourth Hospital of Hebei Medical University , Shijiazhuang , Hebei , PR China.
authors.forename: Shenghui
authors.initials: S
authors.lastname: Liu
authors.affiliation: a Research Center, the Fourth Hospital of Hebei Medical University , Shijiazhuang , Hebei , PR China ;
authors.forename: Meixiang
authors.initials: M
authors.lastname: Sang
authors.affiliation: b Department of Otolaryngology , the Fourth Hospital of Hebei Medical University , Shijiazhuang , Hebei , PR China.
authors.forename: Yuru
authors.initials: Y
authors.lastname: Xu
authors.affiliation: a Research Center, the Fourth Hospital of Hebei Medical University , Shijiazhuang , Hebei , PR China ;
authors.forename: Lina
authors.initials: L
authors.lastname: Gu
authors.affiliation: a Research Center, the Fourth Hospital of Hebei Medical University , Shijiazhuang , Hebei , PR China ;
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.affiliation: a Research Center, the Fourth Hospital of Hebei Medical University , Shijiazhuang , Hebei , PR China ;
authors.forename: Baoen
authors.initials: B
authors.lastname: Shan
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D002681:China / Q000453:epidemiology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D058950:Melanoma-Specific Antigens / Q000378:metabolism*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
chemical_list: D058950:Melanoma-Specific Antigens
keywords: MAGE-A1; MAGE-A11; MAGE-A9; laryngeal squamous cell carcinoma (LSCC); prognosis