title: Efficiency of gentamicin loaded in bacterial polysaccharides microcapsules against intracellular Gram-positive and Gram-negative invasive pathogens.
abstract: Gentamicin is an aminoglycoside antibiotic with a wide spectrum of anti-bacterial activity, but however, due to its high solubility in water, it poorly penetrates inside the cells. This major inconvenient constitutes an important challenge for the treatment of intracellular bacterial infections, which might be solved using appropriate delivery systems for the targeted release of the bioactive agents at the intracellular sites of infection. Thus, in the case of antibiotics, the use drug delivery systems may contribute to increase their therapeutic activity against intracellular pathogens. This paper presents an efficient polymeric delivery system for the intracellular release of gentamicin based on bacterial polysaccharides.
authors.affiliation: Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania; danedmih@gmail.com.
authors.forename: Cristina Doina
authors.initials: CD
authors.lastname: Croitoru
authors.forename: Dan Eduard
authors.initials: DE
authors.lastname: Mihaiescu
authors.forename: Mariana Carmen
authors.initials: MC
authors.lastname: Chifiriuc
authors.forename: Alexandra
authors.initials: A
authors.lastname: Bolocan
authors.forename: Coralia
authors.initials: C
authors.lastname: Bleotu
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
authors.forename: Crina Maria
authors.initials: CM
authors.lastname: Saviuc
authors.forename: Veronica
authors.initials: V
authors.lastname: Lazăr
authors.forename: Carmen
authors.initials: C
authors.lastname: Curuţiu
mesh_terms: D002214:Capsules; D005453:Fluorescence; D005839:Gentamicins / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D042541:Intracellular Space / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D011135:Polysaccharides, Bacterial / Q000737:chemistry*
chemical_list: D002214:Capsules; D005839:Gentamicins; D011135:Polysaccharides, Bacterial