title: Role of the neural pathway from hindbrain to hypothalamus in the regulation of energy homeostasis in rats.
abstract: Recent evidence suggests that neural pathways from the hindbrain to the hypothalamus are important for informing the hypothalamus of the body's condition with regard to energy metabolism. Here we examined energy metabolism in rats with transections of the midbrain that severed the neural pathway from the hindbrain to the hypothalamus, and then investigated the levels of various molecules associated with control of energy metabolism in these rats. Food intake and body weight were higher in the midbrain-transected rats than in sham-operated rats. In addition, the midbrain-transected rats showed insulin resistance and hyperleptinemia. Furthermore, the hypothalamic mRNA levels of anorectic proopiomelanocortin and cocaine- and amphetamine-related transcript were significantly lower in midbrain-transected rats than in sham-operated rats. Our findings elucidate the mechanisms of food intake and energy balance from the perspective of multifactorial regulatory systems that underlie functions such as neurohormonal integration.
authors.affiliation: Frontier Science Research Center, University of Miyazaki, Miyazaki 889-1692, Japan; Department of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Utoyama
authors.affiliation: Frontier Science Research Center, University of Miyazaki, Miyazaki 889-1692, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Akieda-Asai
authors.affiliation: Psychiartric & Neurological Disease Field, Asubio Pharma, Kobe 650-0047, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Koda
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nunoi
authors.affiliation: Frontier Science Research Center, University of Miyazaki, Miyazaki 889-1692, Japan. Electronic address: dateyuka@med.miyazaki-u.ac.jp.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Date
mesh_terms: D000818:Animals; D001835:Body Weight; D004435:Eating; D004734:Energy Metabolism; D005951:Glucose Tolerance Test; D006706:Homeostasis; D007031:Hypothalamus / Q000502:physiology*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008297:Male; D009434:Neural Pathways; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D017208:Rats, Wistar; D054411:Receptors, Leptin / Q000235:genetics / Q000378:metabolism; D012249:Rhombencephalon / Q000502:physiology*
chemical_list: D020738:Leptin; D012333:RNA, Messenger; D054411:Receptors, Leptin; D011333:Pro-Opiomelanocortin
keywords: Energy homeostasis; Food intake; Leptin signaling