title: [Effect of Acanthopanax senticosus Polysaccharides on Cardiac Endogenous Metabolism in Rats Based on Metabolomics].
abstract: OBJECTIVE
  Using metabolomics method to study the influence of Acanthopanax senticosus polysaccharides on cardiac endogenous metabolism in rats, in order to find potential biomarkers and analyze the metabolic pathways which can explore the pharmacological effects and mechanisms of action.
  
  
  METHODS
  20 SD rats were randomly divided into two groups, the blank and Acanthopanax senticosus polysaccharides treatment groups, which were treated with saline and Acanthopanax senticosus polysaccharide for 20 days. On the 21th day,heart tissue were collected and each sample extract was analyzed by UPLC-Q-TOF/MS.
  
  
  RESULTS
  20 potential biomarkers and 6 major metabolic pathways related to cardiovascular and cerebrovascular diseases were identified.
  
  
  CONCLUSIONS
  Acanthopanax senticosus polysaccharides has a certain pharmacological effects on cardio-cerebro vascular diseases, cancer and other diseases. Its mechanism may be related to the metabolic process of amino acids, fatty acid and folate.
authors.forename: Fang
authors.initials: F
authors.lastname: Lu
authors.forename: Xiao-dan
authors.initials: XD
authors.lastname: Yang
authors.forename: Yue-e
authors.initials: YE
authors.lastname: Jing
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.forename: Shu-min
authors.initials: SM
authors.lastname: Liu
mesh_terms: D000818:Animals; D015415:Biomarkers; D028001:Eleutherococcus / Q000737:chemistry*; D006321:Heart / Q000187:drug effects*; D053858:Metabolic Networks and Pathways; D055432:Metabolomics; D009206:Myocardium / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015415:Biomarkers; D010936:Plant Extracts; D011134:Polysaccharides