title: Differential effects of co-administration of oxotremorine with SCH 23390 on impulsive choice in high-impulsive rats and low-impulsive rats.
abstract: The effect of acetylcholine on impulsive choice is thought to be due to interactions between cholinergic and dopaminergic systems, but this hypothesis has not been proven. This study investigated whether D1-like receptors were involved in the effects of the muscarinic cholinergic agonist oxotremorine on impulsive choice in high-impulsive rats (HI rats, n=8) and low-impulsive rats (LI rats, n=8) characterized by basal levels of impulsive choice in a delay-discounting task. The results revealed that oxotremorine (0.05mg/kg) significantly increased the choice of the large reinforcer in HI rats, whereas decreased the choice of the large reinforcer in LI rats. The D1-like antagonist SCH 23390 produced significant reductions in the large-reinforcer choice in HI rats (0.01mg/kg) and LI rats (0.005, 0.0075, and 0.01mg/kg). SCH 23390 significantly inhibited the increase in the choice of the large reinforcer induced by oxotremorine (0.05mg/kg) in HI rats at doses of 0.005 and 0.0075mg/kg, but enhanced the effect of oxotremorine in LI rats only at the dose of 0.0075mg/kg. These findings suggested that D1-like receptors might be involved in the differential effects of oxotremorine on impulsive choice between HI rats and LI rats.
authors.affiliation: Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, Beijing 100048, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Tian
authors.affiliation: Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, Beijing 100048, China.
authors.forename: Xingna
authors.initials: X
authors.lastname: Qin
authors.affiliation: Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, Beijing 100048, China.
authors.forename: Jinling
authors.initials: J
authors.lastname: Sun
authors.affiliation: Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, Beijing 100048, China. Electronic address: lixw701@sina.cn.
authors.forename: Xinwang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address: 18930173636@189.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Wei
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000008:administration & dosage*; D002755:Choice Behavior / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007175:Impulsive Behavior / Q000187:drug effects*; D018721:Muscarinic Agonists / Q000008:administration & dosage*; D010095:Oxotremorine / Q000008:administration & dosage*; D051381:Rats
chemical_list: D001552:Benzazepines; D018721:Muscarinic Agonists; C534628:SCH 23390; D010095:Oxotremorine
keywords: Delay discounting; Impulsive choice; Oxotremorine; Rat; SCH 23390