title: Human mutL homolog 1 expression characteristic and prognostic effect on patients with sporadic colorectal cancer.
abstract: The aim of the present study was to analyze the relationship between aberrant human mutL homolog 1 (hMLH1) expression and clinicopathological parameters of patients with sporadic colorectal cancer, and to explore the prognostic effect of aberrant hMLH1 expression in these patients. The relationship was measured by chi-square test and Fisher's exact test. Survival analysis was performed with Kaplan-Meier analysis and Cox regression model to measure 5-year disease-free survival (DFS) and 5-year overall survival (OS) rates. Totally 17.13% of the patients with sporadic colorectal cancer showed aberrant nuclear staining for hMLH1 expression. Aberrant hMLH1 expression was related with tumor pathologic types, tumor location and TNM staging (P<0.05) in the patients with sporadic colorectal cancer. Cox regression analysis indicated important prognostic factors were age (RR: 1.021, 95% CI: 1.003-1.039, P=0.023), mucinous adenocarcinoma (RR: 2.603, 95% CI: 1.705-3.974, P<0.0001), TNM staging (RR: 2.071, 95% CI: 1.170-3.666, P=0.012), lymphangion invasion (RR: 2.013, 95% CI: 1.227-3.303, P=0.006) and aberrant hMLH1 expression (RR: 0.414, 95% CI: 0.216-0.791, P=0.008). Consequently, hMLH1 expression level is related with some clinicopathologic features. Aberrant hMLH1 expression plays a significant part in prognosis for patients with sporadic colorectal cancer and it will promisingly become an independent prognostic factor.
authors.affiliation: Department of Gastroenterology, The Third Xiangya Hospital of Central South University Changsha, Hunan Province, China.
authors.forename: Chibin
authors.initials: C
authors.lastname: Pu
authors.affiliation: Department of Gastroenterology, The Third Xiangya Hospital of Central South University Changsha, Hunan Province, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Ren
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqi, Xinjiang Uygur Autonomous Region, China; Cancer Research Institute of Central South UniversityChangsha, Hunan Province, China.
authors.forename: Zhenqiang
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Xinjiang Medical University Urumqi, Xinjiang Uygur Autonomous Region, China.
authors.forename: Xianbo
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Gastroenterology, The Third Xiangya Hospital of Central South University Changsha, Hunan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Department of Gastroenterology, The Third Xiangya Hospital of Central South University Changsha, Hunan Province, China.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Huang
authors.affiliation: Department of Gastroenterology, The Third Xiangya Hospital of Central South UniversityChangsha, Hunan Province, China; Hunan Key Laboratory of Nonresolving Inflammation and CancerChangsha, Hunan Province, China.
authors.forename: Shourong
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Gastroenterology, The Third Xiangya Hospital of Central South UniversityChangsha, Hunan Province, China; Hunan Key Laboratory of Nonresolving Inflammation and CancerChangsha, Hunan Province, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
keywords: correlation; hMLH1; prognosis; sporadic colorectal cancer