title: Utility of in-house fluconazole disk diffusion susceptibility testing in the treatment of candidemia.
abstract: Among 302 first candidemia episodes, 210 (69.6%) were initially treated with an echinocandin or polyene (E/P) antifungal drug. In 137 (72.5%) patients with fluconazole-susceptible isolates, treatment was changed to fluconazole based on disk diffusion susceptibility testing. Clinical outcomes were not compromised in patients receiving E/P who were de-escalated to fluconazole for treatment of candidemia based on disk diffusion results.
authors.affiliation: Department of Pharmacy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Division of Infectious Diseases, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address: dwkubiak@partners.org.
authors.forename: David W
authors.initials: DW
authors.lastname: Kubiak
authors.affiliation: Warren Alpert Medical School of Brown University, Division of Infectious Diseases, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02115, USA.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Farmakiotis
authors.affiliation: Department of Pharmacy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Viktoria
authors.initials: V
authors.lastname: Arons
authors.affiliation: Department of Pharmacy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Randy M
authors.initials: RM
authors.lastname: Hollins
authors.affiliation: Department of Pharmacy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Sara E
authors.initials: SE
authors.lastname: Rostas
authors.affiliation: Clinical Microbiology Laboratory, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Linda M
authors.initials: LM
authors.lastname: Weiser
authors.affiliation: Division of Infectious Diseases, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Division of Infectious Diseases, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Lindsey R
authors.initials: LR
authors.lastname: Baden
authors.affiliation: Division of Infectious Diseases, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Division of Infectious Diseases, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Francisco M
authors.initials: FM
authors.lastname: Marty
authors.affiliation: Division of Infectious Diseases, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Division of Infectious Diseases, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: skoo@bwh.harvard.edu.
authors.forename: Sophia
authors.initials: S
authors.lastname: Koo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D058387:Candidemia / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D015331:Cohort Studies; D052978:Disk Diffusion Antimicrobial Tests; D005260:Female; D015725:Fluconazole / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole
keywords: Candidemia; Disk diffusion susceptibility testing; Fluconazole