title: Pre-operative lymph node status of gastric cancer evaluated by multidetector computed tomography.
abstract: The purpose of the present study was to perform a meta-analysis to evaluate the diagnostic value of Multidetector computed tomography (MDCT) in the pre-operative lymph node (N) staging in gastric cancer (GC) patients. The Medline, Embase and Web of Knowledge were searched for studies assessing the diagnostic value of MDCT in the pre-operative evaluation of TNM staging in GC patients. We pooled the sensitivity, specificity, positive and negative Likelihood ratio (LR+ and LR-), Diagnostic Odds Ratio (DOR) and constructed summary receiver operating characteristic curves (ROC). A total of 30 studies including 6637 GC patients were analyzed. The pooled estimates of sensitivity, specificity, LR+, LR- and DOR of MDCT in the detection of pre-operative N staging in GC patients were 0.67 (95% CI: 0.66-0.69 ), 0.84 (95% CI: 0.83-0.85), 3.25 (95% CI: 2.69-3.93), 0.36 (95% CI: 0.28-0.46) and 10.31 (95% CI: 7.66-13.88), respectively. The results of a summary ROC showed that the AUC and Q* were 0.8338 and 0.7661, respectively. As a control, the AUC and Q* of endoscopic ultrasonography were 0.8063 and 0.7414, respectively. Currently, it is necessary to recommend the routine clinical application of MDCT in the preoperative evaluation of lymph node status in GC patients.
authors.affiliation: Department of Function, The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, China; Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Function, The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Han
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, China; Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, China.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wen
keywords: MDCT; Multi-detector computed tomography; gastric cancer; lymph node staging; meta-analysis