title: Lack of Association Between rs17568 Polymorphism in OX40 Gene and Myocardial Infarction, Southern of Iran.
abstract: Tumor necrosis factor (TNF) is one of the inflammatory cytokines which has an important role in inflammation and migration of other inflammatory cells to the atherosclerotic plaques. OX40 is a member of the TNF super family receptor protein. OX40 and OX40 ligand are co-stimulators for T-cells and can increase inflammatory response in atherosclerotic plaques. The aim of this study was to determine the association of rs17568 polymorphism in OX40 gene with premature myocardial infarction. This case control study was done on 100 patients with premature acute myocardial infarction (AMI) and a similar number of sex, age and some other cardiovascular risk factor matched healthy people. The OX40 rs17568 polymorphism was genotyped, using PCR-RFLP method. A-allele frequency of rs17568 SNP was lower non-significantly in Premature AMI, compared to healthy subjects (49% vs. 51%). The analysis of rs17568 (A/G) polymorphism showed an odds ratio of 1.127 (95% CI: 0.635-1.999; P= 0.686) for the GG genotype and 5.761 (95% CI: 1.200-27.655; P= 0.029) for the AG genotype, compared to the AA genotype. The results of this study indicate that the rs17568 SNP of OX40 gene is not associated with premature AMI in the evaluated population.
authors.affiliation: Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran. sotoodehj2002@yahoo.com.
authors.forename: Mehrnoosh
authors.initials: M
authors.lastname: Maalhagh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shojaei
authors.forename: Saeideh
authors.initials: S
authors.lastname: Erfanian
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Sotoodeh Jahromi
authors.forename: Mohammad Sadegh
authors.initials: MS
authors.lastname: Sanie
authors.forename: Alireza
authors.initials: A
authors.lastname: Yusefi
authors.forename: Hassan
authors.initials: H
authors.lastname: Zabetian
authors.forename: Hossein
authors.initials: H
authors.lastname: Hakimelahi
authors.forename: Abdolhossien
authors.initials: A
authors.lastname: Madani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hojjat-Farsangi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007492:Iran; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics*; D053278:OX40 Ligand / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D053278:OX40 Ligand; C089251:TNFSF4 protein, human