title: Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People.
abstract: OBJECTIVE
  Although several forms of sleep disruption are associated with stroke, few studies have examined the relationship between sleep and histopathologic measures of cerebrovascular disease. We tested the hypothesis that greater sleep fragmentation is associated with a higher burden of cerebral vessel and infarct pathology at autopsy.
  
  
  METHODS
  We used ordinal logistic regression models to relate sleep fragmentation measured by actigraphy to the severity of arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy, and the number of macroscopic and microscopic infarcts assessed by structured brain autopsy in 315 participants from the Rush Memory and Aging Project.
  
  
  RESULTS
  Greater sleep fragmentation was associated with more severe arteriolosclerosis (odds ratio, 1.27; 95% confidence interval, 1.02-1.59; P=0.03 per 1 SD greater sleep fragmentation) and more subcortical macroscopic infarcts (odds ratio, 1.31; 95% confidence interval, 1.01-1.68; P=0.04). These associations were independent of established cardiovascular risk factors and diseases, and several medical comorbidities.
  
  
  CONCLUSIONS
  Sleep fragmentation is associated with arteriolosclerosis and subcortical infarcts in older adults.
authors.affiliation: From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chicago, IL. andrew.lim@utoronto.ca.
authors.forename: Andrew S P
authors.initials: AS
authors.lastname: Lim
authors.affiliation: From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chicago, IL.
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.affiliation: From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chicago, IL.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Schneider
authors.affiliation: From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chicago, IL.
authors.forename: David A
authors.initials: DA
authors.lastname: Bennett
authors.affiliation: From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chicago, IL.
authors.forename: Aron S
authors.initials: AS
authors.lastname: Buchman
mesh_terms: D056044:Actigraphy; D000369:Aged, 80 and over; D050379:Arteriolosclerosis / Q000453:epidemiology* / Q000473:pathology; D001344:Autopsy; D020520:Brain Infarction / Q000453:epidemiology / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000453:epidemiology* / Q000473:pathology; D002544:Cerebral Infarction / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D057187:Independent Living; D002537:Intracranial Arteriosclerosis / Q000453:epidemiology* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D012720:Severity of Illness Index; D012892:Sleep Deprivation / Q000453:epidemiology*
keywords: arteriolosclerosis; cerebral infarct; histopathology; sleep; stroke