title: Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents.
abstract: In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as (+)-syringaresinol (1), acanthoside B (2), salvadoraside (3) and acanthoside D (4), lariciresinol-9-O-β-D-glucopyranoside (5) and phenylpropanoids such as 4-[(1E)-3-methoxy-1-propenyl]phenol (6), coniferin (7), and methyl caffeate (8). The extracts and several constituents such as compound 1, 6 and 8 inhibited the production of inflammatory markers, IL-6 and nitric oxide, from IL-1β-treated lung epithelial cells and lipopolysaccharide (LPS)-treated alveolar macrophages. Furthermore, the extracts and compound 4 significantly inhibited lung inflammation in lipolysaccharide-treated acute lung injury in mice by oral administration. Thus it is suggested that A. divaricatus var. albeofructus and its several constituents may be effective against lung inflammation.
authors.affiliation: College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.
authors.forename: Ju Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
authors.forename: Ya Nan
authors.initials: YN
authors.lastname: Sun
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Kim
keywords: Acanthoside; Acantopanax divaricatus var. albeofructus; Lung inflammation; Macrophage