title: Endobronchial ultrasound-guided transbronchial needle aspiration in the staging of lung cancer patients.
abstract: OBJECTIVE
  Mediastinoscopy as diagnostic procedure for evaluation of mediastinum in patients with non-small-cell lung cancer has long been considered the reference standard. However, less invasive method has occurred. Endobronchial ultrasound-guided transbronchial needle aspiration came into widespread use and has resulted in controversy as to whether it is a good replacement for mediastinoscopy. We chose to demonstrate the usefulness of endobronchial ultrasound-guided transbronchial needle aspiration in evaluating the mediastinum in patients with non-small-cell lung cancer.
  
  
  METHODS
  Over a 48-month period, 1841 patients underwent endobronchial ultrasound-guided transbronchial needle aspiration at our healthcare centre. In all patients, 2964 biopsies from the lymph node group N2 and 783 from group N1 were taken. The mean short axis of the lymph nodes biopsied was 2.0 (range: 0.6-2.6). The mean number of lymph node stations biopsied per patient was 2.6. Patients with a negative result of endobronchial ultrasound-guided transbronchial needle aspiration underwent mediastinoscopy. All patients with a negative result in endobronchial ultrasound-guided transbronchial needle aspiration and mediastinoscopy underwent surgical resection with lymph node sampling.
  
  
  RESULTS
  The metastases to lymph nodes N2/N3 and N1 were found in 1111 (60.3%) and 199 (9.3%), respectively. Mediastinoscopy was performed in 730 patients with a positive result in 83 (11.4%) patients. In the group of operated patients, metastatic N1 disease was found in 264 (14.1%). In the group of the operated patients, mediastinal involvement of disease (N2) was found in 30 patients (4.5%). The sensitivity, negative predictive value and diagnostic accuracy for hilar lymph node staging for endobronchial ultrasound-guided transbronchial needle aspiration were 57%, 96% and 96%, respectively. The sensitivity, negative predictive value and diagnostic accuracy per patient for mediastinal lymph node staging for endobronchial ultrasound-guided transbronchial needle aspiration and mediastinoscopy were 91%, 85%, 93% and 73%, 95.5%, 97%, respectively. The specificity and positive predictive value of both tests were 100%.
  
  
  CONCLUSIONS
  The clinical usefulness of endobronchial ultrasound-guided transbronchial needle aspiration is undeniable according to diagnostic performance data. Endobronchial ultrasound-guided transbronchial needle aspiration should be considered complementary to mediastinoscopy in the evaluation of patients with radiographically abnormal mediastinum.
authors.affiliation: Department of Thoracic Surgery, National Research Institute of Chest Diseases, Warsaw, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Dziedzic
authors.affiliation: Department of Thoracic Surgery, National Research Institute of Chest Diseases, Warsaw, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Peryt
authors.affiliation: Department of Patomorphology, National Research Institute of Chest Diseases, Warsaw, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Szolkowska
authors.affiliation: Department of Patomorphology, National Research Institute of Chest Diseases, Warsaw, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Langfort
authors.affiliation: Department of Thoracic Surgery, National Research Institute of Chest Diseases, Warsaw, Poland.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Orlowski
keywords: Surgery; bronchoscopy; lung cancer