title: Synthesis and characterisation of poly(acryalamide) grafted carboxymethyl xanthan gum copolymer.
abstract: In the present work, an unreported graft copolymer of carboxymethyl xanthan gum and acrylamide has been synthesised by free radical polymerisation in a nitrogen atmosphere using ammonium persulphate as an initiator. The optimum reaction conditions adopted for affording maximum percentage of grafting including its grafting efficiency were obtained by varying the concentration of carboxymethyl xanthan gum from 4 to 24 g dm(-3); ammonium persulphate from 5×10(-4) to 30×10(-4)mol dm(-3); acrylamide from 0.4 to 1.2 mol dm(-3); reaction temperature from 55 to 75°C and reaction time from 30 to 90 min. The synthesised graft copolymer has been characterised by (1)H NMR, FTIR spectroscopy, X-ray diffraction measurement, thermal analysis, viscosity measurement and scanning electron microscopy. However, grafting of acrylamide onto carboxymethyl xanthan gum backbone enhanced its thermal stability. This graft copolymer might be well exploited globally as a potential carrier for drug delivery system.
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 491024, Chhattisgarh, India. Electronic address: hemantbadwaik@rediffmail.com.
authors.forename: Hemant Ramchandra
authors.initials: HR
authors.lastname: Badwaik
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 491024, Chhattisgarh, India.
authors.forename: Kalyani
authors.initials: K
authors.lastname: Sakure
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 491024, Chhattisgarh, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Alexander
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 491024, Chhattisgarh, India.
authors.lastname: Ajazuddin
authors.affiliation: Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari 490042, Chhattisgarh, India.
authors.forename: Hemant
authors.initials: H
authors.lastname: Dhongade
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Bhilai 491024, Chhattisgarh, India.
authors.forename: Dulal Krishna
authors.initials: DK
authors.lastname: Tripathi
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D013997:Time Factors; D014783:Viscosity; D014961:X-Ray Diffraction; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D011108:Polymers; D011135:Polysaccharides, Bacterial; D000099166:Polyacrylamides; C002563:xanthan gum
keywords: Acrylamide; Carboxymethyl xanthan gum; Viscosity