title: Influence of High Blood Pressure on Microcirculation in Cerebral Cortex of Young Rats.
abstract: We studied the density and structure of the microvascular network of the pia mater, the blood flow rate and oxygen saturation in the sensorimotor cortex of young spontaneously hypertensive rats (SHR). The density of the microvascular network in hypertensive animals was by ~1.4 times lower than in normotensive Wistar-Kyoto rats (control) and arteriolar bed density was lower by ~1.9 times. The blood flow rate in tissue and oxygen saturation in the sensorimotor cortex in SHR rats were significantly lower than in control animals.
authors.affiliation: Laboratory of Physiology of Cardiovascular and Lymphatic Systems, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. sib@kolt.infran.ru.
authors.forename: I B
authors.initials: IB
authors.lastname: Sokolova
authors.affiliation: Laboratory of Physiology of Cardiovascular and Lymphatic Systems, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Sergeev
authors.affiliation: Laboratory of Physiology of Cardiovascular and Lymphatic Systems, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: D P
authors.initials: DP
authors.lastname: Dvoretskii
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D051381:Rats; D011921:Rats, Inbred WKY
keywords: arterial hypertension; blood flow speed; brain; microcirculation; pial arterioles