title: Effects of obstructive sleep apnea and its treatment over the erectile function: a systematic review.
abstract: Erectile dysfunction (ED) is considered a condition with a broad range of etiologies. Obstructive sleep apnea (OSA) syndrome is one of the lesser studied risk factors for ED. We intend to summarize the current evidence on the relationship between OSA and sexual impairment, focusing on the results in terms of erectile function of the different therapies offered to OSA patients. A systematic review was conducted, selecting articles related to the physiology of OSA and ED, and to the treatments of OSA syndrome and their reported outcomes in erectile and sexual function. Higher prevalences of ED in the OSA groups have been published. However, whether this effect on the erectile function occurs in the entire range of OSA severities remains unclear. Several hypotheses were proposed to explain the physiology of this association. Continuous Positive Airway Pressure as a treatment for OSA patients with ED has achieved a significative improvement in the sexual parameters in most of the studies. Phosphodiesterase type 5 inhibitors (iPDE5) on demand are useful as a treatment for ED in this subgroup of patients, with high satisfaction rates. The surgical treatment for the OSA evidenced benefits over the erectile function, and the effect on the sexual satisfaction of the therapy using Mandibular Advancement Devices is still undefined.
authors.affiliation: Urology Department, Marques de Valdecilla University Hospital, Santander, 39008, Spain.|Institute of Investigation Marques de Valdecilla, Santander, 39011, Spain.
authors.forename: Felix
authors.initials: F
authors.lastname: Campos-Juanatey
authors.affiliation: Oral and Maxillofacial Surgery Department, Araba University Hospital, Araba, 01004, Spain.
authors.forename: Marcos
authors.initials: M
authors.lastname: Fernandez-Barriales
authors.affiliation: Sleep and Ventilation Unit, Marques de Valdecilla University Hospital, Santander, 39008, Spain.
authors.forename: Monica
authors.initials: M
authors.lastname: Gonzalez
authors.affiliation: Urology Department, Marques de Valdecilla University Hospital, Santander, 39008, Spain.|Institute of Investigation Marques de Valdecilla, Santander, 39011, Spain.|Medical and Surgical Sciences Department, School of Medicine, University of Cantabria, Santander, 39011, Spain.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Portillo-Martin
mesh_terms: D007172:Erectile Dysfunction / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008297:Male; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000453:epidemiology / Q000628:therapy*
chemical_list: D058986:Phosphodiesterase 5 Inhibitors