title: Peripheral T-Cell Lymphoma, Not Otherwise Specified and Concurrent Seminoma in Testis.
abstract: Concurrent seminoma and malignant lymphoma of the testis is rare. We present a case of concurrent seminoma and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) in a 54-year-old man who complained of painless left testicular enlargement. Radical left orchiectomy was performed. Macroscopically, the tumor (4.0 × 3.0 cm) was creamy, soft, and homogeneous, and microscopic evaluation revealed an alveolar structure of large cells that formed sheets, as well as colonization by other abnormal cells in a 1.0 × 1.0 cm area. The portion of the tumor comprising large abnormal cells was diagnosed as a seminoma, which was positive for c-kit by immunohistochemistry; the other portion was diagnosed as CD3/CD8, TIA, and granzyme B-positive PTCL-NOS. These two portions were clearly differentiated from one another. The patient received CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) therapy and achieved complete response for 50 months. To our knowledge, this is the first reported case of synchronous advanced seminoma and PTCL.
authors.affiliation: Department of Hematology, Gifu University Graduate School of Medicine.
authors.forename: Junichi
authors.initials: J
authors.lastname: Kitagawa
authors.forename: Naoe
authors.initials: N
authors.lastname: Goto
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Shibata
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Nakamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kanemura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hara
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Takata
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Sato
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tsurumi
mesh_terms: D015415:Biomarkers; D001706:Biopsy; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007150:Immunohistochemistry; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D018239:Seminoma / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D013737:Testis / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D007143:Immunoglobulin Heavy Chains; D016692:Receptors, Antigen, T-Cell, gamma-delta