title: Appropriate Size of Magnetic Nanoparticles for Various Bioapplications in Cancer Diagnostics and Therapy.
abstract: The development of multifunctional nanoparticles has attracted increasing attention. The versatility of nanoparticles largely depends on their physiochemical properties (especially size). However, the optimized size range may be different for the bioapplications of each function associated with multifunctional nanoparticles. It is important to investigate every optimized size range to ascertain which size enables the best function of the nanoparticles before deciding their final size. In this work, we synthesized a series of monodisperse Fe3O4 nanoparticles with identical surface properties ranging in size from 60 to 310 nm and systematically investigated their biobehavior and application. Our data indicate that compared to their large counterparts, small Fe3O4 nanoparticles exhibited greater cellular internalization and deeper penetration into multicellular spheroids, thus enabling a higher photothermal ablation efficacy in vitro. Interestingly, larger Fe3O4 nanoparticles showed greater accumulation in tumors, thereby inducing more efficient tumor growth inhibition. In addition, 120 nm may be the optimal diameter of Fe3O4 nanoparticles for magnetic resonance imaging and photoacoustic tomography in vitro. However, more efficient in vivo imaging mediated by Fe3O4 nanoparticles will predominantly depend on their high accumulation. Our work presents a different appropriate size range for each biofunction of Fe3O4 nanoparticles, which could be a valuable reference for future nanoparticle design.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Guo
authors.affiliation: Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University , 38 Zheda Road, Hangzhou, Zhejiang 310027, P. R. China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wu
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Zuhua
authors.initials: Z
authors.lastname: Wang
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Qingpo
authors.initials: Q
authors.lastname: Li
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Fenfen
authors.initials: F
authors.lastname: Kong
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Hanbo
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine , 88 Jiefang Road, Hang Zhou, Zhejiang 310009, P. R. China.
authors.forename: Xiuliang
authors.initials: X
authors.lastname: Zhu
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, P. R. China.
authors.forename: Yiping P
authors.initials: YP
authors.lastname: Du
authors.affiliation: National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine , Nanchang, Jiangxi 330006, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jin
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Du
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: You
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D005290:Ferric Compounds / Q000627:therapeutic use*; D006801:Humans; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D010316:Particle Size; D061088:Photoacoustic Techniques; D010789:Phototherapy; D013499:Surface Properties; D023041:Xenograft Model Antitumor Assays
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide
keywords: Fe3O4 nanoparticles; magnetic resonance imaging; nanoparticle size; photoacoustic tomography; photothermal therapy