title: Morphometric changes in liver cirrhosis: aetiological differences correlated with progression.
abstract: OBJECTIVE
  To evaluate the morphometric changes in liver cirrhosis using multidetector CT volumetry and to analyse the differences in morphometric changes among different aetiologies and stages of cirrhosis.
  
  
  METHODS
  Each portal segment with the respective proportion relative to total liver volume was measured in 54 patients without cirrhosis as a control (male/female, 29/25; 62.4 ± 7.6 years) and 250 patients with cirrhosis (male/female, 172/78; 64.6 ± 9.2 years) related to hepatitis virus infection (n = 96), alcoholism (n = 88) and non-alcoholic steatohepatitis (NASH) (n = 66). 149 patients were classified as patients with Child-Pugh Class A, 57 patients as patients with Class B and 44 patients as patients with Class C. The Kruskal-Wallis test was used for statistical analysis (p < 0.05).
  
  
  RESULTS
  Cirrhosis associated with all aetiologies commonly showed atrophy of the medial and anterior segments and right lobe and hypertrophy of the lateral segment and caudate lobe compared with the control (p < 0.05). In Child-Pugh Class A, hypertrophy of the caudate lobe progressed more in alcoholism and NASH than in virus-related aetiologies (p < 0.001). Hypertrophy of the lateral segment and atrophy of the medial and anterior segments and right lobe progressed less in NASH than in cases with virus related and alcoholic cirrhosis (p < 0.001). In patients with Class B, these differences were less prominent than in those with Class A (p < 0.001). In Class C, no significant differences were noted in any segment, regardless of aetiology (p > 0.05).
  
  
  CONCLUSIONS
  Morphometric changes of cirrhosis display different patterns according to aetiology. Differences between aetiologies would decrease with progression of cirrhosis.
  
  
  CONCLUSIONS
  Morphometric changes of cirrhosis display different patterns according to aetiology. Differences between aetiologies would decrease with progression of cirrhosis.
authors.affiliation: Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Kumi
authors.initials: K
authors.lastname: Ozaki
authors.affiliation: Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsui
authors.affiliation: Department of Quantum Medicine Technology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Minami
authors.affiliation: Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Azusa
authors.initials: A
authors.lastname: Kitao
authors.affiliation: Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Gabata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D012189:Retrospective Studies