title: The use of trimethoprim and sulfamethoxazole (TMP-SMX) in dermatology.
abstract: We analyzed publications and articles in the PubMed database about the use of trimethoprim and sulfamethoxazole (TMP-SMX) in dermatology. Literature published in the English language, at least in the past two decades, was reviewed. Specific dermatologic indications for TMP-SMX are few but it is often used as the second- or third- line agent. TMP-SMX is used to treat cutaneous nocardiosis and Aeromonas infections. TMP-SMX is a treatment option for cat - scratch disease, granuloma inguinale, melioidosis and Mycobacterium marinum/fortuitum cutaneous infections. TMP-SMX is an alternate choice for treatment of pyodermas and lymphogranuloma venereum. TMP-SMX has been used to treat acne vulgaris in tetracycline and erythromycin - resistant patients. TMP-SMX is still the preferred empiric antibiotic for methicillin - resistant Staphylococcus aureus skin and soft tissue infection in HIV positive population. TMP-SMX is used in dermatology to treat various skin conditions and is one of the most commonly prescribed sulfonamide drugs. TMP-SMX as monotherapy is an effective treatment option in many diseases but due to drug resistance, a combination therapy-usually of two drugs-may be considered.
authors.affiliation: Department of Dermatology Jagiellonian University Medical College, Skawinska 8, Krakow, Poland. kar.michalek@gmail.com.
authors.forename: Karolina
authors.initials: K
authors.lastname: Michałek
authors.forename: Marta
authors.initials: M
authors.lastname: Lechowicz
authors.forename: Maciej
authors.initials: M
authors.lastname: Pastuszczak
authors.forename: Anna
authors.initials: A
authors.lastname: Wojas-Pelc
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D018461:Soft Tissue Infections / Q000188:drug therapy* / Q000517:prevention & control; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000517:prevention & control; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: co-trimoxazole; combination therapy; cutaneous infections; dermatological indications; sulfamethoxazole; trimethoprim