title: Metachronous Bilateral Extremity Soft Tissue Sarcomas.
abstract: BACKGROUND
  Soft tissue sarcomas (STS) account for approximately 1% of adult malignancies, with 50 to 60% occurring in the extremities. Liposarcoma is the most common type of STS and represent about 20% of total adult sarcomas. There are rare syndromes associated with increased risk of developing STS. Further, chemical compounds such as chlorinated phenols and a few chemotherapeutic drugs have been linked to STS, along with ionizing radiation. Nevertheless, the etiology is uncertain for most of these lesions.
  
  
  METHODS
  This report details 2 cases of metachronous bilateral STS of the lower extremities. The first of these presented as a local recurrence of a previously resected right thigh liposarcoma and a new liposarcoma in the left thigh. As mentioned above, among the different subtypes of STS, liposarcoma has the highest tendency for multifocality. The second patient had multifocal metachronous leiomyosarcoma with lung metastases occurring simultaneously with the second presentation. Leiomyosarcoma is another subtype reported to present with multifocal disease.
  
  
  CONCLUSIONS
  Despite the rarity of bilateral lesions, their occurrence should not be overlooked in the initial diagnosis and follow-up of the initially detected tumor. Early detection can affect patient survival because their presence predicts unfavorable outcomes.
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Tawam Hospital, Al Ain, United Arab Emirates.
authors.forename: Ghodratollah
authors.initials: G
authors.lastname: Nowrasteh
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Tawam Hospital, Al Ain, United Arab Emirates.
authors.forename: Tanim
authors.initials: T
authors.lastname: Aziz
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Al Mafraq Hospital, Abu Dhabi, United Arab Emirates.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Al Assas
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Tawam Hospital, Al Ain, United Arab Emirates.
authors.forename: Lateefa
authors.initials: L
authors.lastname: Al Nuaimi
authors.affiliation: Department of Pathology, FMHS, UAE Unuversity, Al Ain, United Arab Emirates.
authors.forename: Saeeda
authors.initials: S
authors.lastname: Marzouqi
authors.affiliation: Department of Pathology, Tawam Hospital, Al Ain, United Arab Emirates.
authors.forename: Asif A M
authors.initials: AA
authors.lastname: Quadri
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Tawam Hospital, Al Ain, United Arab Emirates.
authors.forename: Sadir
authors.initials: S
authors.lastname: Alrawi
mesh_terms: D000328:Adult; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology* / Q000556:secondary; D008080:Liposarcoma / Q000473:pathology*; D035002:Lower Extremity / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000473:pathology*