title: Application of Tauroursodeoxycholic Acid for Treatment of Neurological and Non-neurological Diseases: Is There a Potential for Treating Traumatic Brain Injury?
abstract: The objective of this review was to evaluate the potential of tauroursodeoxycholic acid (TUDCA) for neuroprotection in traumatic brain injury (TBI) patients in the neurocritical care setting. Specifically, we surveyed preclinical studies describing the neuroprotective and systemic effects of TUDCA, and the potential therapeutic application of TUDCA. Preclinical studies have provided promising data supporting its use in neurological disease characterized by apoptosis-induced neuronal loss. TUDCA inhibits multiple proteins involved in apoptosis and upregulates cell survival pathways. In addition, TUDCA exhibits anti-inflammatory effects in models of neuroinflammation and attenuates neuronal loss in chronic neurodegenerative diseases. This may be applicable to TBI, which also triggers inflammatory and apoptotic processes. Additionally, preliminary data support the use of pharmacological therapies that reduce apoptosis and inflammation associated with TBI. The anti-apoptotic and anti-inflammatory mechanisms of TUDCA could prove promising in the treatment of TBI. Currently, there are no published data supporting improvement in clinical outcomes of TBI by treatment with TUDCA, but future studies should be considered.
authors.affiliation: Department of Neurology, University of Minnesota, MMC 295, 420 Delaware Street S.E., Minneapolis, MN, 55455, USA.|Medical School, University of Minnesota, Twin Cites Campus, Minneapolis, MN, USA.
authors.forename: Kyle R
authors.initials: KR
authors.lastname: Gronbeck
authors.affiliation: Faculty of Pharmacy, Research Institute for Medicines (iMed.ULisboa), University of Lisbon, Lisbon, Portugal.
authors.forename: Cecilia M P
authors.initials: CM
authors.lastname: Rodrigues
authors.affiliation: Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Mahmoudi
authors.affiliation: Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Bershad
authors.affiliation: Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Ling
authors.affiliation: Department of Neurology, University of Minnesota, MMC 295, 420 Delaware Street S.E., Minneapolis, MN, 55455, USA.
authors.forename: Salam P
authors.initials: SP
authors.lastname: Bachour
authors.affiliation: Department of Neurology, University of Minnesota, MMC 295, 420 Delaware Street S.E., Minneapolis, MN, 55455, USA. divani@umn.edu.|Department of Neurological Surgery, University of Minnesota, Minneapolis, MN, USA. divani@umn.edu.|Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA. divani@umn.edu.
authors.forename: Afshin A
authors.initials: AA
authors.lastname: Divani
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D000070642:Brain Injuries, Traumatic / Q000188:drug therapy*; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D013655:Taurochenodeoxycholic Acid / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D018696:Neuroprotective Agents; D013655:Taurochenodeoxycholic Acid; C031655:ursodoxicoltaurine
keywords: Apoptosis; Blast injury; Edema; Intracerebral hemorrhage; Intracranial pressure; Neuroinflammation; Neuroprotection; Stroke; Tauroursodeoxycholic acid; Traumatic brain injury