title: Formation of Hyaline Membranes in the Lungs of Albino Rat as a Result of Exposure to Bleomycin During the Neonatal Period.
abstract: We studied the effect of bleomycin (1 mg/kg) in 1-day-old rat pups (single intraperitoneal injection) and 4-day-old pups (3 injections on postnatal days 1, 2, and 3). The formation of hyaline membranes against the background of oxidative stress was documented in all bleomycin-treated rats. Repeated injection of bleomycin (4-day-old pups) led to more pronounced destructive alterations in the lungs characterized by the formation of microcysts and atelectases as well as hypertrophy of the interstitial connective tissue. These alterations persisted in 14-day-old rats. Administration of bleomycin during the neonatal period can be a promising approach to simulation of hyaline membrane disease (respiratory distress syndrome).
authors.affiliation: Department of Histology, Far-Eastern State Medical University, Khabarovsk, Russia.
authors.forename: B Ya
authors.initials: BY
authors.lastname: Ryzhavskii
authors.affiliation: Department of Histology, Far-Eastern State Medical University, Khabarovsk, Russia. leoaf@mail.ru.|Research Institute of Maternal and Child Health Care, Khabarovsk Branch of Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Khabarovsk, Russia. leoaf@mail.ru.
authors.forename: O A
authors.initials: OA
authors.lastname: Lebed'ko
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001761:Bleomycin / Q000494:pharmacology*; D006818:Hyalin / Q000187:drug effects / Q000378:metabolism*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D012128:Respiratory Distress Syndrome / Q000378:metabolism / Q000473:pathology
chemical_list: D001761:Bleomycin
keywords: bleomycin; experimental model; free radical oxidation; hyaline membranes; lungs