title: Hyperthermia using nanoparticles--Promises and pitfalls.
abstract: An ever-increasing body of literature affirms the physical and biological basis for sensitisation of tumours to conventional therapies such as chemotherapy and radiation therapy by mild temperature hyperthermia. This knowledge has fuelled the efforts to attain, maintain, measure and monitor temperature via technological advances. A relatively new entrant in the field of hyperthermia is nanotechnology which capitalises on locally injected or systemically administered nanoparticles that are activated by extrinsic energy sources to generate heat. This review describes the kinds of nanoparticles available for hyperthermia generation, their activation sources, their characteristics, and the unique opportunities and challenges with nanoparticle-mediated hyperthermia.
authors.affiliation: a Department of Microbiology, Biochemistry and Immunology , Morehouse School of Medicine , Atlanta , Georgia , USA .
authors.forename: Punit
authors.initials: P
authors.lastname: Kaur
authors.affiliation: b Department of Radiation Oncology , University of Texas MD Anderson Cancer Center , Houston , Texas , USA .|c Graduate School of Biomedical Sciences, University of Texas Health Science Center and Medical School at Houston , Houston , Texas , USA , and.
authors.forename: Maureen L
authors.initials: ML
authors.lastname: Aliru
authors.affiliation: b Department of Radiation Oncology , University of Texas MD Anderson Cancer Center , Houston , Texas , USA .
authors.forename: Awalpreet S
authors.initials: AS
authors.lastname: Chadha
authors.affiliation: d Deanship for Scientific Research, University of Dammam , Dammam , Saudi Arabia.
authors.forename: Alexzander
authors.initials: A
authors.lastname: Asea
authors.affiliation: b Department of Radiation Oncology , University of Texas MD Anderson Cancer Center , Houston , Texas , USA .
authors.forename: Sunil
authors.initials: S
authors.lastname: Krishnan
mesh_terms: D000818:Animals; D006046:Gold / Q000627:therapeutic use; D006801:Humans; D006979:Hyperthermia, Induced; D060328:Magnetic Phenomena; D053758:Nanoparticles / Q000627:therapeutic use*; D037742:Nanotubes, Carbon; D009369:Neoplasms / Q000628:therapy
chemical_list: D037742:Nanotubes, Carbon; D006046:Gold
keywords: Cancer; hyperthermia; nanoparticles