title: Synthesis and antitumor activity evaluation of lamiridosin A derivatives.
abstract: A series of lamiridosin A derivatives were synthesized through simple procedures. Their antitumor activities were evaluated against EC9706, MGC803, and B16 cell lines in vitro. Several compounds showed potent antitumor activity, especially compound 10, with IC50 value of 2.36 μmol/L against MGC803 cell lines, is more potent than marketed positive drug 5-fluorouridine (5-FU).
authors.affiliation: a Pharmacy College , Xinxiang Medical University , Xinxiang 453003 , China.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Yang
authors.affiliation: a Pharmacy College , Xinxiang Medical University , Xinxiang 453003 , China.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Yan
authors.affiliation: a Pharmacy College , Xinxiang Medical University , Xinxiang 453003 , China.
authors.forename: Fu-Lin
authors.initials: FL
authors.lastname: Yan
authors.affiliation: a Pharmacy College , Xinxiang Medical University , Xinxiang 453003 , China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Yin
authors.affiliation: a Pharmacy College , Xinxiang Medical University , Xinxiang 453003 , China.
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Zhuang
authors.affiliation: a Pharmacy College , Xinxiang Medical University , Xinxiang 453003 , China.
authors.forename: Zi-Yang
authors.initials: ZY
authors.lastname: Ji
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D039823:Iridoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014529:Uridine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D039823:Iridoids; C546311:lamiridosin A; C001943:5-fluorouridine; D014529:Uridine
keywords: Lamiridosin A; antitumor; ether derivatives; iridoids; triazole