title: New developments in microextraction techniques in bioanalysis. A review.
abstract: In recent years, the interest in new extraction methods with lower sample volume requirements, simpler equipment and handling, and lower reagent consumption, has led to the development of a series of microextraction methods based on extraction phases in the microliter order. Nowadays, many references can be found for several of these methods, which imply a wide range of applications referred to both the analyte and the sample nature. In this paper, recent developments in both well-established microextraction techniques (solid phase microextraction, hollow-fiber liquid phase microextraction, dispersive liquid-liquid microextraction, etc.) and recently appeared microextraction procedures (nanoextraction systems, microchip devices, etc.) for the clinical analysis of biological samples will be reviewed and discussed.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Ocaña-González
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain; Research Centre of Health and Environment (CYSMA), University of Huelva, Spain.
authors.forename: Rut
authors.initials: R
authors.lastname: Fernández-Torres
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain. Electronic address: mabello@us.es.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Bello-López
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain; Department of Analytical Chemistry, Lineberger Cancer Center (School of Medicine), The University of North Carolina at Chapel Hill, NC, United States.
authors.forename: María
authors.initials: M
authors.lastname: Ramos-Payán
mesh_terms: D056656:Lab-On-A-Chip Devices; D059627:Liquid Phase Microextraction / Q000379:methods*; D008567:Membranes, Artificial; D052617:Solid Phase Microextraction / Q000379:methods*
chemical_list: D008567:Membranes, Artificial
keywords: Biological samples; Electromembrane microextraction; Liquid phase microextraction; Microchip device; Nanoextraction; Solid phase microextraction