title: Associations of TM6SF2 167K allele with liver enzymes and lipid profile in children: the PANIC Study.
abstract: The 167K allele in the TM6SF2 gene has been suggested to protect against cardiovascular disease at the cost of developing nonalcoholic fatty liver disease in adults.
  
  
  
  We performed a cross-sectional study in a population sample of 462 Caucasian children aged 6-9 y, genotyped the polymorphism using HumanCoreExome BeadChip, and assessed several cardiometabolic risk factors.
  
  
  
  The 51 (11%) carriers of the 167K allele had higher plasma alanine aminotransferase (ALT) (20.8 vs. 18.4 U/l, P = 0.011) but lower plasma triglycerides (0.54 vs. 0.61 mmol/l, P = 0.024), total cholesterol (4.08 vs. 4.30 mmol/l, P = 0.016), and low-density lipoprotein (LDL) cholesterol (2.22 vs. 2.38 mmol/l, P = 0.012) than the 411 noncarriers. In factor analysis, the first factor was heavily loaded by plasma ALT (factor loading 0.63), triglycerides (-0.82), LDL cholesterol (-0.71), and waist circumference (0.61) in the carriers but not in the noncarriers.
  
  
  
  The carriers of the 167K allele have higher plasma ALT but lower plasma triglycerides and total and LDL cholesterol than the noncarriers already in childhood.
authors.affiliation: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Viitasalo
authors.affiliation: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.|Department of Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Pihlajamäki
authors.affiliation: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.|Institute of Biomedicine, Bioinformatics Center, University of Eastern Finland, Kuopio, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Paananen
authors.affiliation: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Atalay
authors.affiliation: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
authors.forename: Virpi
authors.initials: V
authors.lastname: Lindi
authors.affiliation: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.|Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Timo A
authors.initials: TA
authors.lastname: Lakka
mesh_terms: D000410:Alanine Transaminase / Q000097:blood*; D000483:Alleles; D002318:Cardiovascular Diseases / Q000235:genetics / Q000517:prevention & control; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D065626:Non-alcoholic Fatty Liver Disease / Q000235:genetics / Q000517:prevention & control; D012307:Risk Factors; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D008078:Cholesterol, LDL; D008055:Lipids; D008565:Membrane Proteins; C419195:TM6SF2 protein, human; D014280:Triglycerides; D000410:Alanine Transaminase