title: Middle cerebellar peduncles: Magnetic resonance imaging and pathophysiologic correlate.
abstract: We describe common and less common diseases that can cause magnetic resonance signal abnormalities of middle cerebellar peduncles (MCP), offering a systematic approach correlating imaging findings with clinical clues and pathologic mechanisms. Myelin abnormalities, different types of edema or neurodegenerative processes, can cause areas of abnormal T2 signal, variable enhancement, and patterns of diffusivity of MCP. Pathologies such as demyelinating disorders or certain neurodegenerative entities (e.g., multiple system atrophy or fragile X-associated tremor-ataxia syndrome) appear to have predilection for MCP. Careful evaluation of concomitant imaging findings in the brain or brainstem; and focused correlation with key clinical findings such as immunosuppression for progressive multifocal leukoencephalopahty; hypertension, post-transplant status or high dose chemotherapy for posterior reversible encephalopathy; electrolyte disorders for myelinolysis or suspected toxic-drug related encephalopathy; would yield an appropriate and accurate differential diagnosis in the majority of cases.
authors.affiliation: Humberto Morales, Thomas Tomsick, Department of Neuroradiology, University of Cincinnati Medical Center, Cincinnati, OH 45267-0761, United States.
authors.forename: Humberto
authors.initials: H
authors.lastname: Morales
authors.affiliation: Humberto Morales, Thomas Tomsick, Department of Neuroradiology, University of Cincinnati Medical Center, Cincinnati, OH 45267-0761, United States.
authors.forename: Thomas
authors.initials: T
authors.lastname: Tomsick
keywords: Brachium pontis; Magnetic resonance imaging; Middle cerebellar peduncle; Multiple sclerosis; Posterior reversible encephalopathy; Progressive multifocal leukoencephalopathy; Toxic encephalopathy