title: Pharmacokinetics of intravenous moxifloxacin in the cerebrospinal fluid of a patient with central nervous system shunt infection.
abstract: We report the first case describing the pharmacokinetics of moxifloxacin in the cerebrospinal fluid after multiple-dose intravenous administration in a patient with central nervous system shunt infection. The ratio of the area under the concentration-time curve over 24h (AUC) in cerebrospinal fluid to the AUC in serum was 0.7 in this patient.
authors.affiliation: Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zeng
authors.affiliation: Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Mei
authors.affiliation: Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: fu_pumch@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
mesh_terms: D061605:Administration, Intravenous; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D020806:Central Nervous System Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy*; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077266:Moxifloxacin
keywords: Cerebrospinal fluid; Intravenous; Moxifloxacin; Pharmacokinetics