title: Authors' response to comments.
authors.affiliation: Section of Medical Statistics, Medical University of Vienna, Spitalgasse 23, Wien, 1090, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Bauer
authors.affiliation: Novartis Pharma AG, Lichtstrasse 35, Basel, 4002, Switzerland.
authors.forename: Frank
authors.identifier: http://orcid.org/0000-0002-2008-8340
authors.initials: F
authors.lastname: Bretz
authors.affiliation: Johnson and Johnson, 1400 McKean Rd, Spring House, PA, 19477, U.S.A.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Dragalin
authors.affiliation: Section of Medical Statistics, Medical University of Vienna, Spitalgasse 23, Wien, 1090, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: König
authors.affiliation: Institute for Medical Statistics, Informatics and Epidemiology, University of Cologne, 50924 Köln, Germany.
authors.forename: Gernot
authors.initials: G
authors.lastname: Wassmer