title: Three New Chlorinated Cyclopentenols, Palmaenols A and B and Palmaetriol, from the Discomycete Lachnum palmae.
abstract: The new chlorinated cyclopentenols, palmaenol A (1) and palmaetriol (3), were isolated from the culture broth of the discomycete Lachnum palmae (NBRC- 106495). In addition, a new chlorinated cyclopentenol, palmaenol B (2), a geometric isomer of 1, was also obtained from the culture broth containing KCl. The structures of 1-3 were elucidated from spectroscopic data. Compounds 1-3 are cyclopentenols containing three or two chlorines; 1 and 2 are also reduced forms of palmaenones A (4) and B (5), which have been isolated from the same discomycete, respectively. Compounds 4 and 5 had potent antimicrobial activity, while compounds 1-3 showed no such activity. Thus, it is suggested that the unsaturated carbonyl group at C-6 has an important role for the antimicrobial activity.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Takunori
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hosoya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Shigemori
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D003517:Cyclopentanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D054879:Halogenation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D003517:Cyclopentanes; C000604857:palmaenol A; C000604858:palmaenol B; C000604859:palmaetriol