title: A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction.
abstract: Cigarette smoking has been shown to be a health hazard. In addition to being considered a negative lifestyle behavior, studies have shown that cigarette smoking has been linked to genetic underpinnings of hypertension. Because African Americans have the highest incidence and prevalence of hypertension, we examined the joint effect of genetics and cigarette smoking on health among this understudied population. The sample included African Americans from the genome wide association studies of HyperGEN (N = 1083, discovery sample) and GENOA (N = 1427, replication sample), both part of the FBPP. Results suggested that 2 SNPs located on chromosomes 14 (NEDD8; rs11158609; raw p = 9.80 × 10(-9), genomic control-adjusted p = 2.09 × 10(-7)) and 17 (TTYH2; rs8078051; raw p = 6.28 × 10(-8), genomic control-adjusted p = 9.65 × 10(-7)) were associated with SBP including the genetic interaction with cigarette smoking. These two SNPs were not associated with SBP in a main genetic effect only model. This study advances knowledge in the area of main and joint effects of genetics and cigarette smoking on hypertension among African Americans and offers a model to the reader for assessing these risks. More research is required to determine how these genes play a role in expression of hypertension.
authors.affiliation: School of Nursing, Yale University, Orange.
authors.forename: Jacquelyn Y
authors.initials: JY
authors.lastname: Taylor
authors.affiliation: Division of Biostatistics, School of Medicine, Washington University in St. Louis, St. Louis.
authors.forename: Karen
authors.initials: K
authors.lastname: Schwander
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor.
authors.forename: Sharon L R
authors.initials: SL
authors.lastname: Kardia
authors.affiliation: Department of Epidemiology, School of Public Health, University of Alabama, Birmingham.
authors.forename: Donna
authors.initials: D
authors.lastname: Arnett
authors.affiliation: Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liang
authors.affiliation: Cardiovascular Genetics Division, School of Medicine, University of Utah, Salt Lake City.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Hunt
authors.affiliation: Division of Biostatistics, School of Medicine, Washington University in St. Louis, St. Louis.
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
authors.affiliation: Department of Epidemiology, Rollins School of Public Health, Emory University.|Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta.
authors.forename: Yan V
authors.initials: YV
authors.lastname: Sun
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics*; D000368:Aged; D001794:Blood Pressure / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking