title: Hypolipidemic Effects of Phospholipids (PL) Containing n-3 Polyunsaturated Fatty Acids (PUFA) Are Not Dependent on Esterification of n-3 PUFA to PL.
abstract: Phospholipids (PL) containing n-3 polyunsaturated fatty acids (PUFA) have beneficial effects of maintaining and promoting health compared with triacylglycerols (TAG) containing n-3 PUFA or general PL. This study evaluated the effects of dietary PL containing n-3 PUFA and elucidated the effects of the glycerophosphate structure and n-3 PUFA on fatty acid (FA) metabolism in rats. Rats were fed a basal diet containing soybean oil alone, TAG containing n-3 PUFA (1.8%), soybean PL (2.7%), PL containing n-3 PUFA (2.7%), or TAG containing n-3 PUFA (1.8%) + soybean PL (2.7%). The present n-3 PUFA-supplemented diets had similar FA compositions, and the PL diets had similar PL compositions. TAG containing n-3 PUFA reduced serum TAG contents, but did not affect serum cholesterol contents compared with soybean oil alone. PL diets containing n-3 PUFA and the combination of TAG containing n-3 PUFA and soybean PL resulted in decreased serum and liver TAG contents compared with the diet containing soybean oil alone, reflecting enhanced liver FA β-oxidation. The results of this study show that TAG containing n-3 PUFA with added soybean PL affects serum and liver TAG and cholesterol contents to a similar degree as PL containing n-3 PUFA. TAG containing n-3 PUFA and soybean PL are widely used as functional food ingredients and pharmaceutical constituents and are inexpensive compared with PL containing n-3 PUFA. Therefore, the combination of TAG containing n-3 PUFA and soybean PL has potential as a useful and inexpensive component of functional foods.
authors.affiliation: Laboratory of Food and Nutritional Sciences, Faculty of Chemistry, Materials, and Bioengineering, Kansai University, Suita, Osaka, 564-8680, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Fukunaga
authors.affiliation: Laboratory of Food and Nutritional Sciences, Faculty of Chemistry, Materials, and Bioengineering, Kansai University, Suita, Osaka, 564-8680, Japan. hryotan@kansai-u.ac.jp.
authors.forename: Ryota
authors.initials: R
authors.lastname: Hosomi
authors.affiliation: Laboratory of Food and Nutritional Sciences, Faculty of Chemistry, Materials, and Bioengineering, Kansai University, Suita, Osaka, 564-8680, Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Fukao
authors.affiliation: Laboratory of Food and Nutritional Sciences, Faculty of Chemistry, Materials, and Bioengineering, Kansai University, Suita, Osaka, 564-8680, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Miyauchi
authors.affiliation: Department of Public Health, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kanda
authors.affiliation: Department of Public Health, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan.
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Nishiyama
authors.affiliation: Laboratory of Food and Nutritional Sciences, Faculty of Chemistry, Materials, and Bioengineering, Kansai University, Suita, Osaka, 564-8680, Japan.
authors.forename: Munehiro
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D004032:Diet; D004951:Esterification; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D055951:Functional Food; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D010743:Phospholipids / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015525:Fatty Acids, Omega-3; D000960:Hypolipidemic Agents; D010743:Phospholipids
keywords: Fatty acid metabolism; Phospholipid; Rat; n-3 Polyunsaturated fatty acids