title: Comparison of the Efficacy and Safety of a Pharmacokinetic Model-Based Dosing Scheme Versus a Conventional Fentanyl Dosing Regimen For Patient-Controlled Analgesia Immediately Following Robot-Assisted Laparoscopic Prostatectomy: A Randomized Clinical Trial.
abstract: Conventional, intravenous, patient-controlled analgesia, which is only administered by demand bolus without basal continuous infusion, is closely associated with inappropriate analgesia. Pharmacokinetic model-based dosing schemes can quantitatively describe the time course of drug effects and achieve optimal drug therapy. We compared the efficacy and safety of a conventional dosing regimen for intravenous patient-controlled analgesia that was administered by demand bolus without basal continuous infusion (group A) versus a pharmacokinetic model-based dosing scheme performed by decreasing the dosage of basal continuous infusion according to the model-based simulation used to achieve a targeted concentration (group B) following robot-assisted laparoscopic prostatectomy.In total, 70 patients were analyzed: 34 patients in group A and 36 patients in group B. The postoperative opioid requirements, pain scores assessed by the visual analog scale, and adverse events (eg, nausea, vomiting, pruritis, respiratory depression, desaturation, sedation, confusion, and urinary retention) were compared on admission to the postanesthesia care unit and at 0.5, 1, 4, 24, and 48 h after surgery between the 2 groups. All patients were kept for close observation in the postanesthesia care unit for 1 h, and then transferred to the general ward.The fentanyl requirements in the postanesthesia care unit for groups A and B were 110.0 ± 46.4 μg and 77.5 ± 35.3 μg, respectively. The pain scores assessed by visual analog scale at 0.5, 1, 4, and 24 h after surgery in group B were significantly lower than in group A (all P < 0.05). There were no differences in the adverse events between the 2 groups.We found that the pharmacokinetic model-based dosing scheme resulted in lower opioid requirements, lower pain scores, and no significant adverse events in the postanesthesia care unit following robot-assisted laparoscopic prostatectomy in comparison with conventional dosing regimen.
authors.affiliation: From the Department of Anesthesiology and Pain Medicine (S-JJ, S-UP, J-MY, J-HC, J-HH, Y-KK); Department of Clinical Pharmacology and Therapeutics (H-SL); and Department of Nursing, Asan Medical Center, Seoul, Republic of Korea (Y-JK).
authors.forename: Seok-Joon
authors.initials: SJ
authors.lastname: Jin
authors.forename: Hyeong-Seok
authors.initials: HS
authors.lastname: Lim
authors.forename: Youn-Ju
authors.initials: YJ
authors.lastname: Kwon
authors.forename: Se-Ung
authors.initials: SU
authors.lastname: Park
authors.forename: Jung-Min
authors.initials: JM
authors.lastname: Yi
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Chin
authors.forename: Jai-Hyun
authors.initials: JH
authors.lastname: Hwang
authors.forename: Young-Kug
authors.initials: YK
authors.lastname: Kim
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011468:Prostatectomy; D012371:Robotics
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl