title: Stimulation of food intake after central administration of gonadotropin-inhibitory hormone is similar in genetically selected low and high body weight lines of chickens.
abstract: Gonadotropin-inhibitory hormone (GnIH), first isolated from the brain of the Japanese quail (Coturnix japonica), when centrally administered exerts orexigenic effects in birds. However, the precise mechanisms mediating this effect are poorly understood and limited information is available on this effect in models of body weight dysfunction. Thus, the purpose of the present study was to investigate appetite-associated effects of GnIH in chicks from lines that have been selected for either low or high body weight, and are anorexic or become obese, respectively. Central GnIH injection increased food intake in both lines with a similar magnitude of response. There was no effect on water intake. Hypothalamic GnIH mRNA was greater in the low than high weight lines and was greater in the fasted than fed chicks. GnIH receptor mRNA was similarly expressed in both lines, and was greater in fed than fasted chicks. Thus, although selection for body weight did not alter the effect of GnIH on feeding, fasting increased GnIH mRNA in both lines implying that it is an innate hunger factor.
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA, United States.
authors.forename: Betty R
authors.initials: BR
authors.lastname: McConn
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA, United States.
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Yi
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA, United States.
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Gilbert
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA, United States.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Siegel
authors.affiliation: Division for Experimental Natural Science, Faculty of Arts and Science, Kyushu University, Fukuoka 819-0395, Japan.
authors.forename: Vishwajit S
authors.initials: VS
authors.lastname: Chowdhury
authors.affiliation: Department of Bioresource Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA, United States. Electronic address: macline2@vt.edu.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Cline
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000235:genetics*; D001715:Bird Diseases / Q000235:genetics*; D001835:Body Weight / Q000235:genetics*; D002645:Chickens / Q000235:genetics*; D003370:Coturnix / Q000235:genetics*; D004435:Eating; D006062:Gonadotropins / Q000494:pharmacology; D007028:Hypothalamic Hormones / Q000235:genetics*
chemical_list: D030161:Avian Proteins; D006062:Gonadotropins; D007028:Hypothalamic Hormones; C413752:gonadotropin-inhibitory hormone, Coturnix japonica
keywords: Chicks; Food intake; Gonadotropin-inhibitory hormone; Hypothalamus