title: A GC-FID method for quantitative analysis of N,N-carbonyldiimidazole.
abstract: N,N-Carbonyldiimidazole (CDI), a common synthetic reagent used in commercial scale pharmaceutical synthesis, is known to be sensitive to hydrolysis from ambient moisture. This liability demands a simple, robust analytical method to quantitatively determine reagent quality to ensure reproducible performance in chemical reactions. This work describes a protocol for a rapid GC-FID based analysis of CDI.
authors.affiliation: Department of Process and Analytical Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, United States. Electronic address: claire_lee2@merck.com.
authors.forename: Claire
authors.initials: C
authors.lastname: Lee
authors.affiliation: Department of Process and Analytical Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, United States. Electronic address: ian_mangion@merck.com.
authors.forename: Ian
authors.initials: I
authors.lastname: Mangion
mesh_terms: D002849:Chromatography, Gas / Q000379:methods*; D005410:Flame Ionization / Q000379:methods*; D007093:Imidazoles / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry
chemical_list: D007093:Imidazoles; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; C006900:N,N-carbonyldiimidazole
keywords: CDI; Derivatization; GC; N,N-Carbonyldiimidazole