title: Aetiology of Acute Respiratory Tract Infections in Hospitalised Children in Cyprus.
abstract: In order to improve clinical management and prevention of viral infections in hospitalised children improved etiological insight is needed. The aim of the present study was to assess the spectrum of respiratory viral pathogens in children admitted to hospital with acute respiratory tract infections in Cyprus. For this purpose nasopharyngeal swab samples from 424 children less than 12 years of age with acute respiratory tract infections were collected over three epidemic seasons and were analysed for the presence of the most common 15 respiratory viruses. A viral pathogen was identified in 86% of the samples, with multiple infections being observed in almost 20% of the samples. The most frequently detected viruses were RSV (30.4%) and Rhinovirus (27.4%). RSV exhibited a clear seasonality with marked peaks in January/February, while rhinovirus infections did not exhibit a pronounced seasonality being detected almost throughout the year. While RSV and PIV3 incidence decreased significantly with age, the opposite was observed for influenza A and B as well as adenovirus infections. The data presented expand our understanding of the epidemiology of viral respiratory tract infections in Cypriot children and will be helpful to the clinicians and researchers interested in the treatment and control of viral respiratory tract infections.
authors.affiliation: Cyprus Institute of Neurology and Genetics, Department of Molecular Virology, Nicosia, Cyprus.
authors.forename: Jan
authors.initials: J
authors.lastname: Richter
authors.affiliation: Cyprus Institute of Neurology and Genetics, Department of Molecular Virology, Nicosia, Cyprus.
authors.forename: Christakis
authors.initials: C
authors.lastname: Panayiotou
authors.affiliation: Cyprus Institute of Neurology and Genetics, Department of Molecular Virology, Nicosia, Cyprus.
authors.forename: Christina
authors.initials: C
authors.lastname: Tryfonos
authors.affiliation: Cyprus Institute of Neurology and Genetics, Department of Molecular Virology, Nicosia, Cyprus.
authors.forename: Dana
authors.initials: D
authors.lastname: Koptides
authors.affiliation: Archbishop Makarios III Hospital, Department of Pediatrics, Nicosia, Cyprus.
authors.forename: Maria
authors.initials: M
authors.lastname: Koliou
authors.affiliation: Archbishop Makarios III Hospital, Department of Pediatrics, Nicosia, Cyprus.
authors.forename: Nikolas
authors.initials: N
authors.lastname: Kalogirou
authors.affiliation: Archbishop Makarios III Hospital, Department of Pediatrics, Nicosia, Cyprus.
authors.forename: Eleni
authors.initials: E
authors.lastname: Georgiou
authors.affiliation: Cyprus Institute of Neurology and Genetics, Department of Molecular Virology, Nicosia, Cyprus.
authors.forename: Christina
authors.initials: C
authors.lastname: Christodoulou
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D060085:Coinfection; D003535:Cyprus / Q000453:epidemiology; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000209:etiology*; D012621:Seasons; D014777:Virus Diseases / Q000453:epidemiology / Q000821:virology