title: Shape analysis of hypertrophic and hypertensive heart disease using MRI-based 3D surface models of left ventricular geometry.
abstract: The focus of this study was to develop advanced mathematical tools to construct high-resolution 3D models of left-ventricular (LV) geometry to evaluate focal geometric differences between patients with hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) using cardiac magnetic resonance (MR) cross-sectional images. A limiting factor in 3D analysis of cardiac MR cross-sections is the low out-of-plane resolution of the acquired images. To overcome this problem, we have developed a mathematical framework to construct a population-based high-resolution 3D LV triangulated surface (template) in which an iterative matching algorithm maps a surface mesh of a normal heart to a set of cross-sectional contours that were extracted from short-axis cine cardiac MR images of patients who were diagnosed with either HCM or HHD. A statistical analysis was conducted on deformations that were estimated at each surface node to identify shape differences at end-diastole (ED), end-systole (ES), and motion-related shape variation from ED to ES. Some significant shape difference in radial thickness was detected at ES. Differences of LV 3D surface geometry were identified focally on the basal anterior septum wall. Further research is needed to relate these findings to the HCM morphological substrate and to design a classifier to discriminate among different etiologies of LV hypertrophy.
authors.affiliation: Center for Imaging Science, Johns Hopkins University, USA; Institute for Computational Medicine, Johns Hopkins University, USA. Electronic address: sardekani@jhu.edu.
authors.forename: Siamak
authors.initials: S
authors.lastname: Ardekani
authors.affiliation: Center for Imaging Science, Johns Hopkins University, USA.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Jain
authors.affiliation: Center for Imaging Science, Johns Hopkins University, USA.
authors.forename: Alianna
authors.initials: A
authors.lastname: Sanzi
authors.affiliation: Johns Hopkins University Medical Institutions, USA.
authors.forename: Celia P
authors.initials: CP
authors.lastname: Corona-Villalobos
authors.affiliation: Johns Hopkins University Medical Institutions, USA.
authors.forename: Theodore P
authors.initials: TP
authors.lastname: Abraham
authors.affiliation: Johns Hopkins University Medical Institutions, USA.
authors.forename: M Roselle
authors.initials: MR
authors.lastname: Abraham
authors.affiliation: Johns Hopkins University Medical Institutions, USA.
authors.forename: Stefan L
authors.initials: SL
authors.lastname: Zimmerman
authors.affiliation: Johns Hopkins University Medical Institutions, USA.
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Wu
authors.affiliation: Institute for Computational Medicine, Johns Hopkins University, USA.
authors.forename: Raimond L
authors.initials: RL
authors.lastname: Winslow
authors.affiliation: Center for Imaging Science, Johns Hopkins University, USA; Institute for Computational Medicine, Johns Hopkins University, USA.
authors.forename: Michael I
authors.initials: MI
authors.lastname: Miller
authors.affiliation: Center for Imaging Science, Johns Hopkins University, USA; Institute for Computational Medicine, Johns Hopkins University, USA.
authors.forename: Laurent
authors.initials: L
authors.lastname: Younes
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000473:pathology*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D015233:Models, Statistical; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume
keywords: 3D left-ventricular geometry; Cardiac MRI; Cardiomyopathy; Surface-to-contour mapping