title: Intimate Partner Violence PTSD and Neural Correlates of Inhibition.
abstract: Posttraumatic stress disorder (PTSD) has been linked to deficits in response inhibition, and neuroimaging research suggests this may be due to differences in prefrontal cortex recruitment. The current study examined relationships between PTSD from intimate partner violence (IPV) and neural responses during inhibition. There were 10 women with PTSD from IPV and 12 female control subjects without trauma history who completed the stop signal task during functional magnetic resonance imaging. Linear mixed models were used to investigate group differences in activation (stop-nonstop and hard-easy trials). Those with PTSD exhibited greater differential activation to stop-nonstop trials in the right dorsolateral prefrontal cortex and the anterior insula and less differential activation in several default mode regions (d = 1.12-1.22). Subjects with PTSD exhibited less differential activation to hard-easy trials in the lateral frontal and the anterior insula regions (driven by less activation to hard trials) and several default mode regions (i.e., medial prefrontal cortex, posterior cingulate; driven by greater activation to easy trials; d = 1.23-1.76). PTSD was associated with difficulties disengaging default mode regions during cognitive tasks with relatively low cognitive demand, as well as difficulties modulating executive control and salience processing regions with increasing cognitive demand. Together, these results suggest that PTSD may relate to decreased neural flexibility during inhibition.
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma, USA.|Department of Community Medicine, University of Tulsa, Tulsa, Oklahoma, USA.
authors.forename: Robin L
authors.initials: RL
authors.lastname: Aupperle
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma, USA.|Department of Psychology, University of Tulsa, Tulsa, Oklahoma, USA.
authors.forename: Ashley N
authors.initials: AN
authors.lastname: Stillman
authors.affiliation: Research Service, VA San Diego Healthcare System, San Diego, California, USA.|Psychiatry Service, VA San Diego Healthcare System, San Diego, California, USA.|Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California, USA.|Department of Psychiatry, University of California-San Diego, San Diego, California, USA.
authors.forename: Alan N
authors.initials: AN
authors.lastname: Simmons
authors.affiliation: Department of Psychiatry, University of California-San Diego, San Diego, California, USA.
authors.forename: Taru
authors.initials: T
authors.lastname: Flagan
authors.affiliation: Research Service, VA San Diego Healthcare System, San Diego, California, USA.|Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California, USA.|Department of Psychiatry, University of California-San Diego, San Diego, California, USA.|Psychology Service, VA San Diego Healthcare System, San Diego, California, USA.
authors.forename: Carolyn B
authors.initials: CB
authors.lastname: Allard
authors.affiliation: Research Service, VA San Diego Healthcare System, San Diego, California, USA.|Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California, USA.|Department of Psychiatry, University of California-San Diego, San Diego, California, USA.|Psychology Service, VA San Diego Healthcare System, San Diego, California, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Thorp
authors.affiliation: Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California, USA.|Department of Psychiatry, University of California-San Diego, San Diego, California, USA.|Psychology Service, VA San Diego Healthcare System, San Diego, California, USA.
authors.forename: Sonya B
authors.initials: SB
authors.lastname: Norman
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma, USA.|Psychiatry Service, VA San Diego Healthcare System, San Diego, California, USA.|Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California, USA.|Department of Psychiatry, University of California-San Diego, San Diego, California, USA.
authors.forename: Martin P
authors.initials: MP
authors.lastname: Paulus
authors.affiliation: Psychiatry Service, VA San Diego Healthcare System, San Diego, California, USA.|Family Medicine and Public Health, University of California-San Diego, San Diego, California, USA.
authors.forename: Murray B
authors.initials: MB
authors.lastname: Stein
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D004644:Emotions / Q000502:physiology*; D056344:Executive Function; D005260:Female; D006801:Humans; D000066511:Intimate Partner Violence / Q000523:psychology*; D008279:Magnetic Resonance Imaging; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011603:Psychophysiology; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology