title: Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging.
abstract: ADAM10 is one of the key players in ectodomain-shedding of the amyloid-β protein precursor (AβPP). Previous research with postmortem tissue has shown reduced expression and activity of ADAM10 within the central nervous system (CNS) of Alzheimer's disease (AD) patients. Determination of cerebral ADAM10 in living humans is hampered by its transmembrane property; only the physiological AβPP cleavage product generated by ADAM10, sAβPPα, can be assessed in cerebrospinal fluid. Establishment of surrogate markers in easily accessible material therefore is crucial. It has been demonstrated that ADAM10 is expressed in platelets and that platelet amount is decreased in AD patients. Just recently it has been shown that platelet ADAM10 and cognitive performance of AD patients positively correlate. In contrast to AD patients, to our knowledge almost no information has been published regarding ADAM10 expression during normal aging. We investigated ADAM10 amount and activity in platelets of cognitively healthy individuals from three different age groups ranging from 22-85 years. Interestingly, we observed an age-dependent increase in ADAM10 levels and activity in platelets.
authors.forename: Florian
authors.initials: F
authors.lastname: Schuck
authors.forename: Dominik
authors.initials: D
authors.lastname: Wolf
authors.forename: Andreas
authors.initials: A
authors.lastname: Fellgiebel
authors.forename: Kristina
authors.initials: K
authors.lastname: Endres
mesh_terms: D051722:ADAM Proteins / Q000097:blood*; D000072197:ADAM10 Protein; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000235:genetics; D053829:Amyloid Precursor Protein Secretases / Q000097:blood*; D016564:Amyloid beta-Protein Precursor / Q000097:blood; D000704:Analysis of Variance; D053327:Apolipoprotein E4 / Q000235:genetics; D003071:Cognition; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D039661:Integrin beta3 / Q000097:blood; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D009483:Neuropsychological Tests; D055815:Young Adult
chemical_list: D016564:Amyloid beta-Protein Precursor; D053327:Apolipoprotein E4; D039661:Integrin beta3; D008565:Membrane Proteins; D053829:Amyloid Precursor Protein Secretases; D051722:ADAM Proteins; D000072197:ADAM10 Protein; C491236:ADAM10 protein, human
keywords: ADAM10; fluorescence activity; normal aging; platelets; resilience factor