title: Singapore Cancer Network (SCAN) Guidelines for the Management of Advanced Castrate-Resistant Prostate Cancer.
abstract: BACKGROUND
  The SCAN genitourinary cancer workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines for the management of advanced castrate-resistant prostate cancer.
  
  
  METHODS
  The workgroup utilised a modified ADAPTE process to calibrate high quality international evidence-based clinical practice guidelines to our local setting.
  
  
  RESULTS
  Five international guidelines were evaluated- those developed by the National Comprehensive Cancer Network (2014), the European Society of Medical Oncology (2013), the American Urological Association (2013), the National Institute of Health and Clinical Excellence (2014) and the American Society of Clinical Oncology and Cancer Care Ontario (2014). Recommendations on the management of advanced castrate-resistant prostate cancer were developed.
  
  
  CONCLUSIONS
  These adapted guidelines form the SCAN Guidelines 2015 for the management of advanced castrate-resistant prostate cancer.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000736:Androstenes / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D019496:Cancer Vaccines / Q000627:therapeutic use*; D000077143:Docetaxel; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008297:Male; D009570:Nitriles; D009919:Orchiectomy; D010669:Phenylthiohydantoin / Q000031:analogs & derivatives / Q000627:therapeutic use; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000473:pathology; D011868:Radioisotopes / Q000627:therapeutic use; D011883:Radium / Q000627:therapeutic use; D012846:Singapore; D043823:Taxoids / Q000627:therapeutic use; D014020:Tissue Extracts / Q000627:therapeutic use
chemical_list: D000726:Androgen Antagonists; D000736:Androstenes; D000970:Antineoplastic Agents; D001549:Benzamides; D019496:Cancer Vaccines; D009570:Nitriles; D011868:Radioisotopes; D043823:Taxoids; D014020:Tissue Extracts; D000077143:Docetaxel; D010669:Phenylthiohydantoin; D007987:Gonadotropin-Releasing Hormone; C552428:cabazitaxel; C511774:sipuleucel-T; C540278:enzalutamide; C089740:abiraterone; D007654:Ketoconazole; C581106:radium Ra 223 dichloride; D011883:Radium