title: Application of robust Generalised Cross-Validation to the inverse problem of electrocardiology.
abstract: Robust Generalised Cross-Validation was proposed recently as a method for determining near optimal regularisation parameters in inverse problems. It was introduced to overcome a problem with the regular Generalised Cross-Validation method in which the function that is minimised to obtain the regularisation parameter often has a broad, flat minimum, resulting in a poor estimate for the parameter. The robust method defines a new function to be minimised which has a narrower minimum, but at the expense of introducing a new parameter called the robustness parameter. In this study, the Robust Generalised Cross-Validation method is applied to the inverse problem of electrocardiology. It is demonstrated that, for realistic situations, the robustness parameter can be set to zero. With this choice of robustness parameter, it is shown that the robust method is able to obtain estimates of the regularisation parameter in the inverse problem of electrocardiology that are comparable to, or better than, many of the standard methods that are applied to this inverse problem.
authors.affiliation: School of Natural Sciences and Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, Queensland 4111, Australia.
authors.forename: Josef P
authors.initials: JP
authors.lastname: Barnes
authors.affiliation: School of Natural Sciences and Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, Queensland 4111, Australia.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Johnston
mesh_terms: D004562:Electrocardiography / Q000379:methods*; D006801:Humans; D008955:Models, Cardiovascular; D012815:Signal Processing, Computer-Assisted
keywords: Electrocardiology; Electrophysiology; Generalised Cross-Validation; Inverse problems; Tikhonov regularisation