title: Skin Glue Reduces the Failure Rate of Emergency Department-Inserted Peripheral Intravenous Catheters: A Randomized Controlled Trial.
abstract: Peripheral intravenous catheters are the most common invasive device in health care yet have very high failure rates. We investigate whether the failure rate could be reduced by the addition of skin glue to standard peripheral intravenous catheter care.
  
  
  
  We conducted a single-site, 2-arm, nonblinded, randomized, controlled trial of 380 peripheral intravenous catheters inserted into 360 adult patients. The standard care group received standard securement. The skin glue group received standard securement plus cyanoacrylate skin glue applied to the skin insertion site. The primary outcome was peripheral intravenous catheter failure at 48 hours, regardless of cause. Secondary outcomes were the individual modes of peripheral intravenous catheter failure: infection, phlebitis, occlusion, or dislodgement.
  
  
  
  Peripheral intravenous catheter failure was 10% lower (95% confidence interval -18% to -2%; P=.02) with skin glue (17%) than standard care (27%), and dislodgement was 7% lower (95% confidence interval -13% to 0%; P=.04). Phlebitis and occlusion were less with skin glue but were not statistically significant. There were no infections.
  
  
  
  This study supports the use of skin glue in addition to standard care to reduce peripheral intravenous catheter failure rates for adult emergency department patients admitted to the hospital.
authors.affiliation: Department of Emergency Medicine, Caboolture Hospital, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia; NHMRC Centre of Research Excellence in Nursing, Centre for Health Practice Innovation, Menzies Health Institute Queensland, Griffith University, Nathan Campus, Brisbane, Queensland, Australia; Critical Care Research Group, the Prince Charles Hospital and University of Queensland, Brisbane, Queensland, Australia. Electronic address: simon.bugden@health.qld.gov.au.
authors.forename: Simon
authors.initials: S
authors.lastname: Bugden
authors.affiliation: Department of Emergency Medicine, Caboolture Hospital, Queensland, Australia.
authors.forename: Karla
authors.initials: K
authors.lastname: Shean
authors.affiliation: Department of Emergency Medicine, Caboolture Hospital, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Mark
authors.initials: M
authors.lastname: Scott
authors.affiliation: Centre for Applied Health Economics, School of Medicine, Menzies Health Institute Queensland, Griffith University, Logan Campus, Queensland, Australia.
authors.forename: Gabor
authors.initials: G
authors.lastname: Mihala
authors.affiliation: Department of Emergency Medicine, Caboolture Hospital, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Sean
authors.initials: S
authors.lastname: Clark
authors.affiliation: Department of Emergency Medicine, Caboolture Hospital, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Christopher
authors.initials: C
authors.lastname: Johnstone
authors.affiliation: NHMRC Centre of Research Excellence in Nursing, Centre for Health Practice Innovation, Menzies Health Institute Queensland, Griffith University, Nathan Campus, Brisbane, Queensland, Australia; Critical Care Research Group, the Prince Charles Hospital and University of Queensland, Brisbane, Queensland, Australia.
authors.forename: John F
authors.initials: JF
authors.lastname: Fraser
authors.affiliation: NHMRC Centre of Research Excellence in Nursing, Centre for Health Practice Innovation, Menzies Health Institute Queensland, Griffith University, Nathan Campus, Brisbane, Queensland, Australia; Critical Care Research Group, the Prince Charles Hospital and University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Claire M
authors.initials: CM
authors.lastname: Rickard
mesh_terms: D000328:Adult; D002406:Catheterization, Peripheral / Q000295:instrumentation*; D003487:Cyanoacrylates; D004868:Equipment Failure; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D053832:Surgical Tape; D014014:Tissue Adhesives
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives