title: [Sporadic cutaneous lymphosarcoma of T-cell origin with involvement of lymph nodes and internal organs in a Holstein cow].
abstract: Sporadic lymphosarcomas in adult cattle are rare entities with an unknown etiology. This case report describes the course of the disease in a 3.5-year-old cow of the breed German Holstein, which was presented to the veterinarian due to multifocal nodular skin lesions. Several superficial lymph nodes (Lymphonodi mandibulares, parotidei and mammariae) were enlarged, had a tight-elastic consistency and were freely movable. The histopathological and immunohistochemical examination of skin biopsies showed the presence of multifocal cutaneous T-cell lymphosarcomas consistent with a skin leukosis. Bovine leukemia virus infection was excluded by serological investigation of a milk sample and virological examination of a tissue sample, respectively. Seven weeks after the first clinical examination, the cow deteriorated rapidly and was euthanized. A post mortem examination revealed the presence of neoplastic cells within lymph nodes (all superficial lymph nodes of the carcass and Lymphonodi pulmonales), kidney and lungs as well as a liver rupture. Additionally, an overview of the case reports of sporadic bovine cutaneous lymphosarcomas published during the previous 15 years will be provided. The legal background for a further utilization of affected animals for milk and meat production will be discussed. This case report illustrates that sporadic bovine leukosis represents an important differential diagnosis for viral-, bacterial- and parasitic-induced skin lesions and enlargement of lymph nodes in adult cattle.
authors.affiliation: Dr. Markus Freick, Straße der Jugend 68, 09306 Zettlitz OT Methau, E-Mail: mfreick@gmx.de.
authors.forename: M
authors.initials: M
authors.lastname: Freick
authors.forename: L
authors.initials: L
authors.lastname: Lapko
authors.forename: M
authors.initials: M
authors.lastname: Neubert
authors.forename: M
authors.initials: M
authors.lastname: Hardt
authors.forename: H
authors.initials: H
authors.lastname: Behn
authors.forename: O
authors.initials: O
authors.lastname: Passarge
authors.forename: S
authors.initials: S
authors.lastname: Schöniger
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D016583:Enzootic Bovine Leukosis / Q000473:pathology*; D037901:Euthanasia, Animal; D005260:Female; D008198:Lymph Nodes / Q000473:pathology*
keywords: Dairy cow; T-lymphocytes; cutaneous tumors; skin leukosis