title: The Utility of Fisher's Geometric Model in Evolutionary Genetics.
abstract: The accumulation of data on the genomic bases of adaptation has triggered renewed interest in theoretical models of adaptation. Among these models, Fisher Geometric Model (FGM) has received a lot of attention over the last two decades. FGM is based on a continuous multidimensional phenotypic landscape, but it is for the emerging properties of individual mutation effects that it is mostly used. Despite an apparent simplicity and a limited number of parameters, FGM integrates a full model of mutation and epistatic interactions that allows the study of both beneficial and deleterious mutations, and subsequently the fate of evolving populations. In this review, I present the different properties of FGM and the qualitative and quantitative support they have received from experimental evolution data. I later discuss how to estimate the different parameters of the model and outline some future directions to connect FGM and the molecular determinants of adaptation.
authors.affiliation: IAME, UMR 1137, INSERM, F-75018 Paris, France ; IAME, UMR 1137, Univ. Paris Diderot, Sorbonne Paris Cité, F-75018 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Tenaillon
keywords: Fisher’s Geometric model; adaptive landscape; distribution of fitness effects; drift load; epistasis; phenotypic complexity; pleiotropy; robustness