title: Metastasized Leydig cell tumor in a dog.
abstract: We present the clinical findings, diagnosis and treatment of an 11-year old intact male Fox Terrier with a malignant Leydig cell tumor of the right testicle, which metastasized to the skeletal musculature of the left hind limb. The primary tumor and the metastasis were resected with narrow margins. The dog was treated with metronomic chemotherapy using thalidomid and dyclophosphamide. Local recurrence at the site of the metastasis and a pulmonary metastasis were present 30 months after surgery. The dog was euthanized.
authors.forename: A
authors.initials: A
authors.lastname: Togni
authors.forename: M
authors.initials: M
authors.lastname: Rütten
authors.forename: C Rohrer
authors.initials: CR
authors.lastname: Bley
authors.forename: K
authors.initials: K
authors.lastname: Hurter
mesh_terms: D059250:Administration, Metronomic / Q000662:veterinary; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant / Q000662:veterinary; D003520:Cyclophosphamide / Q000008:administration & dosage; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D004285:Dogs; D037901:Euthanasia, Animal; D017809:Fatal Outcome; D006614:Hindlimb; D007984:Leydig Cell Tumor / Q000175:diagnosis / Q000556:secondary / Q000628:therapy / Q000662:veterinary*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000662:veterinary; D008297:Male; D019042:Muscle Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000628:therapy / Q000662:veterinary*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D013792:Thalidomide / Q000008:administration & dosage
chemical_list: D020533:Angiogenesis Inhibitors; D018906:Antineoplastic Agents, Alkylating; D013792:Thalidomide; D003520:Cyclophosphamide