title: Amniotic fluid total antioxidant capacity and nitric oxide in emergency cerclage.
abstract: OBJECTIVE
  Nitric oxide (NO) is one of the reactive oxygen species (ROS) that has been associated with inflammation. Total antioxidant capacity (TAC) neutralizes ROS. We evaluated that amniotic fluid (AF) TAC and NO correlate with the outcome of emergency cerclage.
  
  
  METHODS
  Thirty-six women with cervical dilatation (≥2 cm) and bulging membranes between 16 and 24 weeks underwent emergency cerclage. Sixty-seven women between 16 and 24 weeks who had amniocentesis for chromosomal test provided control samples. AF samples were tested for TAC, and NO, and then correlated with pregnancy outcome.
  
  
  RESULTS
  AF TAC was significantly lower in cerclage group than control group (cerclage: 92.6 mmol/L versus control: 127.2 mmol/L, p < 0.001). Higher levels of AF TAC were associated with a longer latency from cerclage to delivery (r = 0.62, p < 0.001). NO was similar between two groups (p = 0.35). The mean gestational age at delivery of control group was better than cerclage group (cerclage: 29.5 weeks versus control: 39.4 weeks, p < 0.01).
  
  
  CONCLUSIONS
  Higher levels of AF TAC are correlated with longer prolongation days after cerclage. However, AF NO and iNOS are not different between two groups.
authors.affiliation: a Department of Obstetrics and Gynecology , Hallym University College of Medicine , Seoul , Republic of Korea and.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Song
authors.affiliation: b Ilsong Institute of Life Science, Hallym University , Anyang, Gyeonggi-Do , Republic of Korea.
authors.forename: Seok Joo
authors.initials: SJ
authors.lastname: Park
authors.affiliation: a Department of Obstetrics and Gynecology , Hallym University College of Medicine , Seoul , Republic of Korea and.
authors.forename: Keun Young
authors.initials: KY
authors.lastname: Lee
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D023802:Cerclage, Cervical; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*; D011247:Pregnancy; D047928:Premature Birth / Q000517:prevention & control
chemical_list: D000975:Antioxidants; D009569:Nitric Oxide; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II
keywords: Amniotic fluid; emergency cerclage; nitric oxide; total antioxidant capacity