title: Meta-analysis reveals PTPN22 1858C/T polymorphism confers susceptibility to rheumatoid arthritis in Caucasian but not in Asian population.
abstract: The PTPN22 1858C/T polymorphism is associated with rheumatoid arthritis (RA). However, reports from the Asian populations are conflicting in nature and lacks consensus. The aim of our study was to evaluate the association between the PTPN22 1858C/T polymorphism and RA in Asian and Caucasian subjects by carrying out a meta-analysis of Asian and Caucasian data. A total of 27 205 RA cases and 27 677 controls were considered in the present meta-analysis involving eight Asian and 35 Caucasian studies. The pooled odds ratios (ORs) were performed for the allele, dominant, and recessive genetic model. No statistically significant association was found between the PTPN22 1858C/T polymorphism and risk of RA in Asian population (allele genetic model: OR = 1.217, 95% confidence interval (CI) = 0.99-1.496, p value 0.061; dominant genetic model: OR = 1.238, 95% CI = 0.982-1.562, p value 0.071; recessive genetic model: OR = 1.964, 95% CI = 0.678-5.693, p value 0.213). A significant association with risk of RA in Caucasian population suggesting that T-- allele does confer susceptibility to RA in this subgroup was observed (allele genetic model: OR = 1.638, 95% CI = 1.574-1.705, p value < 0.0001; dominant genetic model: OR = 1.67, 95% CI = 1.598-1.745, p value < 0.0001; recessive genetic model: OR = 2.65, 95% CI = 2.273-3.089, p value < 0.0001). The PTPN22 1858C/T polymorphism is not associated with RA risk in Asian populations. However, our meta-analysis confirms that the PTPN22 1858C/T polymorphism is associated with RA susceptibility in Caucasians.
authors.affiliation: a Molecular Genetics Laboratory, Department of Medical Lab Technology, College of Applied Medical Sciences, Jazan University , Jazan , Saudi Arabia .
authors.forename: Gowher
authors.initials: G
authors.lastname: Nabi
authors.affiliation: b Department of Laboratory Medicine , Faculty of Applied Medical Sciences, Albaha University , Albaha , Saudi Arabia .
authors.forename: Naseem
authors.initials: N
authors.lastname: Akhter
authors.affiliation: c Research and Scientific Studies Unit , College of Nursing & Allied Health Sciences, Jazan University , Jazan , Saudi Arabia , and.
authors.forename: Mohd
authors.initials: M
authors.lastname: Wahid
authors.affiliation: d Department of Biological Sciences , Rabigh College of Science and Arts, King Abdulaziz University , Rabigh , Jeddah , Saudi Arabia.
authors.forename: Kanchan
authors.initials: K
authors.lastname: Bhatia
authors.affiliation: c Research and Scientific Studies Unit , College of Nursing & Allied Health Sciences, Jazan University , Jazan , Saudi Arabia , and.
authors.forename: Raju Kumar
authors.initials: RK
authors.lastname: Mandal
authors.affiliation: c Research and Scientific Studies Unit , College of Nursing & Allied Health Sciences, Jazan University , Jazan , Saudi Arabia , and.
authors.forename: Sajad Ahmad
authors.initials: SA
authors.lastname: Dar
authors.affiliation: c Research and Scientific Studies Unit , College of Nursing & Allied Health Sciences, Jazan University , Jazan , Saudi Arabia , and.
authors.forename: Arshad
authors.initials: A
authors.lastname: Jawed
authors.affiliation: c Research and Scientific Studies Unit , College of Nursing & Allied Health Sciences, Jazan University , Jazan , Saudi Arabia , and.
authors.forename: Shafiul
authors.initials: S
authors.lastname: Haque
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*; D017594:Publication Bias; D044465:White People / Q000235:genetics*
chemical_list: C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22
keywords: Genetic model; meta-analysis; polymorphism; protein tyrosine phosphatase non-receptor 22; rheumatoid arthritis