title: Antitumor Properties of Modified Detonation Nanodiamonds and Sorbed Doxorubicin on the Model of Ehrlich Ascites Carcinoma.
abstract: We studied antitumor properties of modified detonation nanodiamonds loaded with doxorubicin on in vivo model of Ehrlich ascites carcinoma. The type of tumor development and morphological characteristics of the liver, kidneys, and spleen were evaluated in experimental animals. Modified nanodiamonds injected intraperitoneally produced no antitumor effect on Ehrlich carcinoma. However, doxorubicin did not lose antitumor activity after sorption on modified nanodiamonds.
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Medvedeva
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia. evgen_patolog@mail.ru.
authors.forename: E L
authors.initials: EL
authors.lastname: Zhukov
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.|Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Inzhevatkin
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Bezzabotnov
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D004317:Doxorubicin / Q000737:chemistry* / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D058612:Nanodiamonds / Q000737:chemistry*; D010537:Peritoneum / Q000187:drug effects / Q000473:pathology
chemical_list: D058612:Nanodiamonds; D004317:Doxorubicin
keywords: Ehrlich ascites carcinoma; doxorubicin; nanodiamonds