title: Characteristics of non-valvular atrial fibrillation patients who benefit most from anticoagulation treatment.
abstract: OBJECTIVE
  The objective was to determine who will benefit most from oral anticoagulation (OAC) for non-valvular atrial fibrillation (NVAF) patients aged ≥ 75 years.
  
  
  BACKGROUND
  It was unclear whether all of NVAF aged ≥ 75 should receive OAC.
  
  
  METHODS
  We recruited NVAF ≥ 75 years without QAC who were divided into three groups according to CHA2DS-VASc scores. The clinical endpoints were ischemic stroke (IS), thromboembolism (TE), or death.
  
  
  RESULTS
  The patients with CHA2DS2-VASc score of 6-9 were not appropriate for anticoagulation with the highest HAS-BLED scores. CHA2DS2-VASc of 2 had little risk for IS/TE. We further divided CHA2DS2-VASc of 3-5 into three subgroups with estimated glomerular filtration rate (eGFR; ml/min/1.73 m(2)): < 30, 30-60, and > 60. The patients with eGFR < 30 had the highest bleeding risk with a comparable IS/TE.
  
  
  CONCLUSIONS
  NVAF with CHA2DS2-VASc of 3-5 and eGFR > 30 ml/min/1.73 m(2) represent the most appropriate population for anticoagulation.
authors.affiliation: Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University Beijing, People's Republic of China.
authors.forename: Yun-Li
authors.initials: YL
authors.lastname: Xing
authors.affiliation: Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University Beijing, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University Beijing, People's Republic of China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Ma
authors.affiliation: Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University Beijing, People's Republic of China.
authors.forename: Cui-Ying
authors.initials: CY
authors.lastname: Wang
authors.affiliation: School of Biomedical Engineering, Capital Medical University Beijing, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University Beijing, People's Republic of China.
authors.forename: Ying-Shuo
authors.initials: YS
authors.lastname: Huang
authors.affiliation: Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University Beijing, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
keywords: Atrial fibrillation; CHA2DS2-VASc score; anticoagulation; eGFR; elderly