title: An insulin-binding protein from the venom of a solitary wasp Eumenes pomiformis binds to apolipophorin III in lepidopteran hemolymph.
abstract: EpIBP, an insulin-like peptide-binding protein, is a major protein component of the venom of a solitary hunting wasp, Eumenes pomiformis. To evaluate the bioactivity, bacteria-expressed EpIBP was injected into Spodoptera exigua larvae, resulting in a higher survival rate and reduced loss of body weight under starvation conditions than control larvae. EpIBP was found to interact with apolipophorin III (apoLp III), implying that EpIBP might function by altering the apoLp III-mediated metabolism of prey.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Gyeongsang National University, Jinju 52828, South Korea.
authors.forename: Ji Hyeong
authors.initials: JH
authors.lastname: Baek
authors.affiliation: Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, South Korea. Electronic address: shlee22@snu.ac.kr.
authors.forename: Si Hyeock
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Division of Applied Life Science (BK21Plus), PMBBR & IALS, Gyeongsang National University, Jinju 52828, South Korea.
authors.forename: Woe-Yeon
authors.initials: WY
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, PMBBRC, Gyeongsang National University, Jinju 52828, South Korea. Electronic address: mgk1284@gnu.ac.kr.
authors.forename: Min Gab
authors.initials: MG
authors.lastname: Kim
mesh_terms: D000818:Animals; D001053:Apolipoproteins / Q000737:chemistry / Q000378:metabolism*; D005508:Food Deprivation; D006458:Hemolymph / Q000378:metabolism*; D019476:Insect Proteins / Q000378:metabolism / Q000494:pharmacology*; D007814:Larva / Q000502:physiology; D018411:Spodoptera / Q000378:metabolism*; D013997:Time Factors; D014862:Wasp Venoms / Q000737:chemistry*; D014863:Wasps / Q000502:physiology*
chemical_list: D001053:Apolipoproteins; D019476:Insect Proteins; D014862:Wasp Venoms; C042470:apolipophorin III
keywords: Apolipophorin III; EpIBP; Insulin-binding protein; Solitary hunting wasp; Venom