title: Left atrial aging: a cardiac magnetic resonance feature-tracking study.
abstract: Importance of left atrial (LA) phasic function evaluation is increasingly recognized for its incremental value in terms of prognosis and risk stratification. LA phasic deformation in the pathway of normal aging has been characterized using echocardiographic speckle tracking. However, no data are available regarding age-related variations using feature-racking (FT) techniques from standard cine magnetic resonance imaging (MRI). We studied 94 healthy adults (41 ± 14 yr, 47 women), who underwent MRI and Doppler echocardiography on the same day for left ventricular (LV) diastolic function evaluation. From cine MRI, longitudinal strain and strain rate, radial motion fraction, and radial relative velocity, respectively, corresponding to the reservoir, conduit, and LA contraction phases, were measured using dedicated FT software. Longitudinal strain and radial motion fraction decreased gradually and significantly with aging for both reservoir (r > 0.31, P < 0.003) and conduit (r > 0.54, P < 0.001) phases, whereas they remained unchanged during the LA contraction phase. Subsequently, the LA contraction-to-reservoir ratio increased significantly with age (r > 0.44, P < 0.001). Longitudinal strain rate and radial relative velocity significantly decreased with age (reservoir: r = 0.39, P < 0.001, conduit: r > 0.54, P < 0.001), and these associations tended to be stronger in women than in men. Finally, associations of LA functional indexes with age were stronger in individuals with lower transmitral early-to-atrial maximal velocity ratio and mitral annulus maximal longitudinal velocity, as well as higher transmitral early maximal-to-mitral annulus maximal longitudinal velocity ratio, highlighting the LV-LA interplay. Age-related changes in LA phasic function indexes were quantified by cine MRI images using a FT technique and were significantly related to age and LV diastolic function.
authors.affiliation: Sorbonne Universités, UPMC University Paris 06, INSERM UMRS 1146, CNRS UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, France; ICAN Institute of Cardiometabolism and Nutrition, Paris, France; evinmorgane@gmail.com.
authors.forename: Morgane
authors.initials: M
authors.lastname: Evin
authors.affiliation: Sorbonne Universités, UPMC University Paris 06, INSERM UMRS 1146, CNRS UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, France; ICAN Institute of Cardiometabolism and Nutrition, Paris, France; Department of Cardiovascular Radiology, Institute of Cardiologie, Hôpital Pitié-Salpêtrière, Paris, France; ICAN Imaging Core Laboratory, Paris, France; and.
authors.forename: Alban
authors.initials: A
authors.lastname: Redheuil
authors.affiliation: Paris-Centre de Recherche Cardiovasculaire, INSERM, HEGP, Paris, France; Department of Cardiology, European Hospital Georges Pompidou, Paris, France;
authors.forename: Gilles
authors.initials: G
authors.lastname: Soulat
authors.affiliation: Department of Cardiology, European Hospital Georges Pompidou, Paris, France;
authors.forename: Ludivine
authors.initials: L
authors.lastname: Perdrix
authors.affiliation: Sorbonne Universités, UPMC University Paris 06, INSERM UMRS 1146, CNRS UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, France; Department of Cardiology, European Hospital Georges Pompidou, Paris, France;
authors.forename: Golmehr
authors.initials: G
authors.lastname: Ashrafpoor
authors.affiliation: Sorbonne Universités, UPMC University Paris 06, INSERM UMRS 1146, CNRS UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, France;
authors.forename: Alain
authors.initials: A
authors.lastname: Giron
authors.affiliation: Sorbonne Universités, UPMC University Paris 06, INSERM UMRS 1146, CNRS UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, France; ICAN Institute of Cardiometabolism and Nutrition, Paris, France;
authors.forename: Jérôme
authors.initials: J
authors.lastname: Lamy
authors.affiliation: Department of Cardiology, Institute of Cardiologie, Hôpital Pitié-Salpêtrière, Paris, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Defrance
authors.affiliation: Sorbonne Universités, UPMC University Paris 06, INSERM UMRS 1146, CNRS UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, France; ICAN Institute of Cardiometabolism and Nutrition, Paris, France; Department of Cardiovascular Radiology, Institute of Cardiologie, Hôpital Pitié-Salpêtrière, Paris, France;
authors.forename: Charles
authors.initials: C
authors.lastname: Roux
authors.affiliation: ICAN Institute of Cardiometabolism and Nutrition, Paris, France; Université Pierre et Marie Curie-Paris 6, INSERM UMR-S956, Paris, France; Department of Cardiology, Institute of Cardiologie, Hôpital Pitié-Salpêtrière, Paris, France.
authors.forename: Stéphane N
authors.initials: SN
authors.lastname: Hatem
authors.affiliation: Sorbonne Universités, UPMC University Paris 06, INSERM UMRS 1146, CNRS UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, France; Department of Cardiology, European Hospital Georges Pompidou, Paris, France;
authors.forename: Benoit
authors.initials: B
authors.lastname: Diebold
authors.affiliation: Paris-Centre de Recherche Cardiovasculaire, INSERM, HEGP, Paris, France; Department of Cardiology, European Hospital Georges Pompidou, Paris, France;
authors.forename: Elie
authors.initials: E
authors.lastname: Mousseaux
authors.affiliation: Sorbonne Universités, UPMC University Paris 06, INSERM UMRS 1146, CNRS UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, France; ICAN Institute of Cardiometabolism and Nutrition, Paris, France;
authors.forename: Nadjia
authors.initials: N
authors.lastname: Kachenoura
mesh_terms: D000328:Adult; D000367:Age Factors; D000375:Aging / Q000473:pathology; D016279:Atrial Function, Left; D001696:Biomechanical Phenomena; D015150:Echocardiography, Doppler; D005260:Female; D064368:Healthy Volunteers; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D012737:Sex Factors; D013314:Stress, Mechanical; D013997:Time Factors; D016277:Ventricular Function, Left; D055815:Young Adult
keywords: aging; feature tracking; left atrial function; magnetic resonance imaging