title: Dienogest as preoperative treatment of submucous myomas for hysteroscopic surgery: a prospective, randomized study.
abstract: The aim of this single-center, prospective, randomized, parallel-group study was to compare Dienogest and Danazol as endometrial preparation in patients who have to undergo hysteroscopic surgery for submucous myomas. We enrolled 80 consecutive eligible patients, in reproductive age, affected by submucous myomas. Pre- and posttreatment characterization of endometrium was performed by hysteroscopic visual observation and histologic confirmation. The enrolled patients were randomly assigned to two groups: 40 were treated with 2 mg of Dienogest/die, 40 with 100 mg of Danazol/die, both orally for 5 weeks, starting on day 1 of menstruation. Posttreatment comparison of endometrial patterns showed a significant more marked effect of Dienogest, respect to Danazol, in atrophying endometrium ("normotrophic non-responders" versus "hypotrophic"-"atrophic", p = 0.028). Intraoperative data showed no significant difference between the two groups for cervical dilatation time (p = 0.326), while in the Dienogest group, we found a significant reduction of operative time (p = 0.001), infusion volume (p = 0.001), and severity of bleeding (p = 0.042). Moreover, Dienogest caused less side effects (p = 0.008). According to our data analysis, Dienogest, respect to Danazol, is more effective for the preparation of the endometrium in patients who have to undergo hysteroscopic surgery for submucous myomas, and causes less side effects.
authors.affiliation: a Department of Human Pathology in Adulthood and Childhood "G. Barresi" , Unit of Gynecology and Obstetrics, University of Messina , Messina , Italy and.
authors.forename: Antonio Simone
authors.initials: AS
authors.lastname: Laganà
authors.affiliation: a Department of Human Pathology in Adulthood and Childhood "G. Barresi" , Unit of Gynecology and Obstetrics, University of Messina , Messina , Italy and.
authors.forename: Valentina
authors.initials: V
authors.lastname: Giacobbe
authors.affiliation: a Department of Human Pathology in Adulthood and Childhood "G. Barresi" , Unit of Gynecology and Obstetrics, University of Messina , Messina , Italy and.
authors.forename: Onofrio
authors.initials: O
authors.lastname: Triolo
authors.affiliation: a Department of Human Pathology in Adulthood and Childhood "G. Barresi" , Unit of Gynecology and Obstetrics, University of Messina , Messina , Italy and.
authors.forename: Roberta
authors.initials: R
authors.lastname: Granese
authors.affiliation: b Department of Reproduction , University Medical Center Ljubljana , Ljubljana , Slovenia.
authors.forename: Helena
authors.initials: H
authors.lastname: Ban Frangež
authors.affiliation: b Department of Reproduction , University Medical Center Ljubljana , Ljubljana , Slovenia.
authors.forename: Eda
authors.initials: E
authors.lastname: Vrtačnik-Bokal
authors.affiliation: a Department of Human Pathology in Adulthood and Childhood "G. Barresi" , Unit of Gynecology and Obstetrics, University of Messina , Messina , Italy and.
authors.forename: Chiara
authors.initials: C
authors.lastname: Ietto
authors.affiliation: a Department of Human Pathology in Adulthood and Childhood "G. Barresi" , Unit of Gynecology and Obstetrics, University of Messina , Messina , Italy and.
authors.forename: Vittorio Italo
authors.initials: VI
authors.lastname: Palmara
mesh_terms: D000328:Adult; D003613:Danazol / Q000627:therapeutic use*; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D007889:Leiomyoma / Q000188:drug therapy / Q000601:surgery*; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011300:Preoperative Care; D057234:Preoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000601:surgery*
chemical_list: D006727:Hormone Antagonists; C023635:dienogest; D009277:Nandrolone; D003613:Danazol
keywords: Danazol; Dienogest; hysteroscopic surgery; preoperative treatment; submucous myomas