title: Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo.
abstract: Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol-norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.
authors.affiliation: School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address: dyyan@sjtu.edu.cn.
authors.forename: Deyue
authors.initials: D
authors.lastname: Yan
authors.affiliation: Department of Applied Chemistry, National Chia-Yi University, Chia-Yi City 60004, Taiwan, ROC.
authors.forename: Lin-Kai
authors.initials: LK
authors.lastname: Ni
authors.affiliation: Department of Applied Chemistry, National Chia-Yi University, Chia-Yi City 60004, Taiwan, ROC.
authors.forename: Ho-Lun
authors.initials: HL
authors.lastname: Chen
authors.affiliation: Department of Styling, Tzu Hui Institute of Technology, Pingtung 926, Taiwan, ROC.
authors.forename: Li-Chou
authors.initials: LC
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan, ROC. Electronic address: yauhung@mail.tku.edu.tw.
authors.forename: Yau-Hung
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Applied Chemistry, National Chia-Yi University, Chia-Yi City 60004, Taiwan, ROC. Electronic address: cccheng@mail.ncyu.edu.tw.
authors.forename: Chien-Chung
authors.initials: CC
authors.lastname: Cheng
mesh_terms: D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry; D004625:Embryo, Nonmammalian / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000737:chemistry; D008516:Medicine, Chinese Traditional; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000633:toxicity; D015027:Zebrafish / Q000254:growth & development
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D004337:Drug Carriers; D008081:Liposomes; D013267:Stilbenes; C069741:norcantharidin; D000077185:Resveratrol
keywords: Drug delivery; Liposome; Norcantharidin; Resveratrol; Tadpole structure