title: Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease.
abstract: OBJECTIVE
  Coronary artery lesions (CALs) and a risk for early onset of atherosclerosis are major concerns following Kawasaki disease (KD). Intimal smooth muscle cells (SMCs) have an important role in vascular lesions in KD. It is known that soluble LR11 (sLR11) is a novel biomarker for vascular lesions and LR11 is markedly expressed in intimal SMCs in atherosclerotic lesions. In this study, we hypothesized that sLR11 reflects the presence of vascular lesions late after KD.
  
  
  METHODS
  Twenty-three age-matched controls (group 1) and 59 patients with a history of KD were enrolled; 36 with KD had normal coronary arteries or regressed aneurysms (group 2), and 23 had CALs (group 3).
  
  
  RESULTS
  Serum sLR11 levels in group 3 (median, interquartile range (IQR): 11.1 ng/mL, 9.3-13.9 ng/mL) were significantly higher than those in groups 1 (8.4 ng/mL, 7.1-10.2 ng/mL, p < 0.001) and 2 (9.0 ng/mL, 7.7-10.1 ng/mL, p < 0.01). Levels of sLR11 were positively correlated with levels of high-sensitivity C-reactive protein (r = 0.480, p < 0.01) and lipoprotein (a) (r = 0.486, p < 0.01).
  
  
  CONCLUSIONS
  These findings suggest that sLR11 reflects the development of vascular lesions in patients with serious CALs.
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. Electronic address: kwatanabe@med.niigata-u.ac.jp.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, Sakura, Japan.
authors.forename: Meizi
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Hisanori
authors.initials: H
authors.lastname: Haniu
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Fujito
authors.initials: F
authors.lastname: Numano
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hoshina
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Saitoh
authors.affiliation: Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Uchiyama
authors.affiliation: Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, Sakura, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Bujo
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000209:etiology*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000097:blood*; D008297:Male; D026901:Membrane Transport Proteins / Q000097:blood*; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D011237:Predictive Value of Tests; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; C102582:SORL1 protein, human
keywords: Biomarker; Kawasaki disease; LR11; Smooth muscle cell