title: [Short-term effects of hemogram in healthy donors after peripheral blood stem cell collection].
abstract: OBJECTIVE
  To observe the short- term effects of hemogram in donors after peripheral blood stem cell（PBSC）collection and donors' tolerance.
  
  
  METHODS
  A total of 166 related allogeneic donors were selected from The First Affiliated Hospital of Medical School of Zhejiang University between January 2013 and December 2014, including 86 male and 80 female. All donors accepted granulocytecolony- stimulating factor（G-CSF）5-10 μg·kg⁻¹·d⁻¹ until collection finished and were measured by blood cells count before and after PBSC collection.
  
  
  RESULTS
  After PBSC collection, the hemoglobin level decreased from 145（94-181）g/L to 138（93-167）g/L, and the platelet counts decreased in all donors from 231（105- 490）× 10⁹/L to 95（39- 210）× 10⁹/L. The amount of hemoglobin contamination in collection products was weak correlated with the decreased hemoglobin in peripheral blood（r=0.297, P=0.017）, and the platelet contamination was high correlated with that decreased in peripheral blood（r=0.719, P<0.001）. The decline of hemoglobin level after twice PBSC collection was of no significant difference between four groups in different ages（P≥0.05）. The decline of platelet counts was out of a significant difference（P> 0.05）. In addition, the decline of hemoglobin level after once and twice PBSC collection was of a significant difference between four groups in different body mass index（BMI）（P=0.003 and P<0.001）, especially in thinner group with obvious decrease. But the decline of platelet counts was out of a significant difference （P>0.05）.
  
  
  CONCLUSIONS
  The hemoglobin level decreased mildly in healthy allogeneic hematopoietic stem cell donors after PBSC collection and it is better to adjust parameters every time to ensure their safety for thinner donors. However, it will increase the risk of platelet decline, which is unrelated with ages and BMI and can be tolerated.
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: Wanzhuo
authors.initials: W
authors.lastname: Xie
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: De
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: Xiudi
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: Xiujin
authors.initials: X
authors.lastname: Ye
mesh_terms: D001782:Blood Donors; D001792:Blood Platelets; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D010976:Platelet Count
chemical_list: D006454:Hemoglobins; D016179:Granulocyte Colony-Stimulating Factor