title: Addition of Hyperoxic Component to Adaptation to Hypoxia Prevents Impairments Induced by Low Doses of Toxicants (Free Radical Oxidation and Proteins of HSP Family).
abstract: We studied the possibility of preventing disturbances caused by administration of low doses of toxicants by adaptation to interval hypoxia and hyperoxia. The preventive protective effect of adaptation to hypoxia-hyperoxia manifested in suppression of free radical oxidation, decrease in the levels of HIF-1α and inducible HOx-1, and improvement of tolerance to physical exercises.
authors.affiliation: Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia. yva1950@gmail.com.
authors.forename: T G
authors.initials: TG
authors.lastname: Sazontova
authors.affiliation: Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Stryapko
authors.affiliation: Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Arkhipenko
mesh_terms: D000818:Animals; D001554:Benzene / Q000633:toxicity*; D002857:Chromium / Q000633:toxicity*; D005609:Free Radicals / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D000860:Hypoxia / Q000503:physiopathology*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D005609:Free Radicals; D006360:Heat-Shock Proteins; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D002857:Chromium; C074702:chromium hexavalent ion; D001554:Benzene
keywords: HIF-1α; Hsp proteins; benzene; hyperoxia; hypoxia