title: An Androgen Receptor-positive Carcinoma of the Lacrimal Drainage System Resembling Salivary Duct Carcinoma: Case Report and Review of the Literature.
abstract: Carcinomas of the lacrimal drainage apparatus are rare and due to their aggressive behavior, they usually require extensive surgical treatment. We report a unique case of a 60-year-old man presenting with proptosis found to have a mass in the lacrimal drainage system on magnetic resonance imaging. Histology revealed a high-grade carcinoma with morphologic features of salivary gland duct carcinoma. Immunohistochemistry showed an extensive positive staining to androgen receptor. This is the first report of salivary gland-like duct carcinoma of the lacrimal drainage apparatus. Androgen receptor should be included in the immunohistochemical panel for the diagnostic work-up of lacrimal drainage system carcinomas, which resemble salivary gland duct carcinoma. This finding could have important diagnostic and therapeutic implications.
authors.affiliation: *Pathology Centre-Histopathology ‡Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK †Ophthalmology Unit, Azienda Policlinico Umberto I, University of Rome "La Sapienza," Rome, Italy.
authors.forename: Siavash
authors.initials: S
authors.lastname: Rahimi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lambiase
authors.forename: Peter A
authors.initials: PA
authors.lastname: Brennan
authors.forename: Solmaz
authors.initials: S
authors.lastname: Abdolrahimzadeh
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D007765:Lacrimal Apparatus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011944:Receptors, Androgen / Q000378:metabolism*; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D011944:Receptors, Androgen