title: Ceftaroline Fosamil Use in 2 Pediatric Patients With Invasive Methicillin-Resistant Staphylococcus aureus Infections.
abstract: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is one of the most common pathogens causing pediatric infections including skin and soft tissue infections, pyogenic arthritis, osteomyelitis, and septic shock. For decades, patients were treated with antibiotics such as vancomycin and clindamycin, but there is an increasing incidence of resistance to these traditional therapies. We describe 2 cases of patients with CA-MRSA invasive infections with bacteremia who experienced vancomycin therapy failure but who were successfully treated with ceftaroline fosamil. Case 1 involves an 8-year-old Hispanic male who was diagnosed with CA-MRSA bacteremia, thigh abscess, and osteomyelitis. The patient was admitted to the pediatric intensive care unit in septic shock. Case 2 involves an 8-year-old Caucasian male who was diagnosed with CA-MRSA sepsis, right arm abscess, and osteomyelitis. We were able to successfully treat both patients with CA-MRSA sepsis and invasive infection-who failed vancomycin therapy-with ceftaroline fosamil with no adverse efiects. Despite the positive outcome in both pediatric patients, clinical trials with ceftaroline fosamil are needed to further support its use in pediatric patients.
authors.affiliation: Department of Pharmacy, Huntsville Hospital for Women and Children, Huntsville, Alabama.
authors.forename: Amanda W
authors.initials: AW
authors.lastname: Williams
authors.affiliation: Department of Pharmacy, Huntsville Hospital for Women and Children, Huntsville, Alabama.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Newman
authors.affiliation: Huntsville Hospital, Huntsville, Alabama.
authors.forename: Sara
authors.initials: S
authors.lastname: Ocheltree
authors.affiliation: Department of Pharmacy, Huntsville Hospital for Women and Children, Huntsville, Alabama ; Department of Pharmacy, Texas Children's Hospital, Houston, Texas.
authors.forename: Rachel
authors.initials: R
authors.lastname: Beaty
authors.affiliation: Huntsville Hospital, Huntsville, Alabama.
authors.forename: Ali
authors.initials: A
authors.lastname: Hassoun
keywords: ceftaroline fosamil; child; methicillin-resistant Staphylococcus aureus; osteomyelitis; pediatrics