title: High level of depressive symptoms as a barrier to reach an ideal cardiovascular health. The Paris Prospective Study III.
abstract: We hypothesized that depression might represent a barrier to reach an ideal cardiovascular health (CVH) as estimated by the 7-item tool proposed by the American Heart Association. Between 2008 and 2012, 9,417 subjects 50-75 years of age were examined in a large health center and enrolled in the Paris Prospective Study III (PPS3). Participants with 0-2, 3-4 and 5-7 health metrics at the ideal level were categorized as having poor, intermediate and ideal CVH, respectively. Participants with a score ≥ 7 on the 13-item Questionnaire of Depression 2nd version, Abridged or who were on antidepressants were referred as having high level of depressive symptoms (HLDS). The mean age of the 9417 study participants was 59.57 (SD 6.28) years and 61.16% were males. A total of 9.55% had HLDS. Poor, intermediate and ideal CVH was present in 40.38%, 49.52% and 10.10% of the participants. In multivariate polytomous logistic regression analysis, HLDS was inversely associated with ideal CVH (odds ratio = 0.70; 95% CI: 0.55;0.90). This was driven by an association with the behavioural component of the CVH. Participants with HLDS had a substantial reduced chance of reaching an ideal CVH.
authors.affiliation: INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Gaye
authors.affiliation: INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Prugger
authors.affiliation: INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Perier
authors.affiliation: Preventive and Clinical Investigation Center, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Thomas
authors.affiliation: INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.|APHP, Hospital Broca, Department of Geriatry, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Plichart
authors.affiliation: INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Guibout
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.|APHP, Georges Pompidou European Hospital, Psychiatry Department, Paris, France.|INSERM U894, Neuropsychiatry, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Lemogne
authors.affiliation: Preventive and Clinical Investigation Center, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Pannier
authors.affiliation: INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.|APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Boutouyrie
authors.affiliation: INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.|APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France.
authors.forename: X
authors.initials: X
authors.lastname: Jouven
authors.affiliation: INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Empana
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D003863:Depression / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005602:France; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D011795:Surveys and Questionnaires
chemical_list: D000928:Antidepressive Agents