title: Organ Damage and Quality of Life in Antiphospholipid Syndrome.
abstract: Antiphospholipid syndrome (APS) affects young patients in the most productive years of their life, and the consequences of organic or tissue damage involve a decrease in health-related quality of life (HRQoL). While acute disease manifestations of APS are well known, information on the long-term prognosis and damage in affected patients is still very limited. Systemic lupus erythematosus (SLE) patients would be expected to experience long-term complications and even die as a consequence of APS. Organ damage in APS has been evaluated using different methods and definitions, including the SLICC/ACR Damage Index (SDI), which tend to underestimate aPL-related damage. A new damage index in APS has been proposed (DIAPS), and it seems to be more accurate than SDI. Given the implications for morbidity and mortality, it is imperative to assess accurately aPL-related damage and HRQoL in patients with APS.
authors.affiliation: Hospital Córdoba, Cátedra de Medicina I UHMI n 3, Universidad Nacional de Córdoba, Libertad No. 2051, Córdoba, 5000, Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Alba
authors.affiliation: Grupo de Inmunología Celular e Inmunogenética (GICIG), Universidad de Antioquia, Calle 67 No. 53-108, Medellín, Colombia.
authors.forename: J A
authors.initials: JA
authors.lastname: Gómez-Puerta
authors.affiliation: Unidad de Investigación en Epidemiología Clínica, Hospital General Regional No. 1, IMSS, Universidad Nacional Autónoma de México, Gabriel Mancera # 222, Mexico City, 03100, Mexico.
authors.forename: M V
authors.initials: MV
authors.lastname: Goycochea-Robles
authors.affiliation: Centro Médico ABC, Universidad Nacional Autónoma de México, Sur 136 No. 116, Mexico City, 01120, Mexico. marycarmenamigo@gmail.com.
authors.forename: M C
authors.initials: MC
authors.lastname: Amigo
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications / Q000534:rehabilitation*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000534:rehabilitation; D011379:Prognosis; D011594:Psychometrics; D011788:Quality of Life; D012720:Severity of Illness Index; D013927:Thrombosis / Q000209:etiology
keywords: Antiphospholipid syndrome (APS); Damage index in APS (DIAPS); Health-related quality of life (HRQoL); Organ damage; Quality of life; SLICC/ACR Damage Index (SDI); Systemic autoimmune diseases (SAD)