title: Assessing the quality of proton PBS treatment delivery using machine log files: comprehensive analysis of clinical treatments delivered at PSI Gantry 2.
abstract: Pencil beam scanning (PBS) proton therapy requires the delivery of many thousand proton beams, each modulated for position, energy and monitor units, to provide a highly conformal patient treatment. The quality of the treatment is dependent on the delivery accuracy of each beam and at each fraction. In this work we describe the use of treatment log files, which are a record of the machine parameters for a given field delivery on a given fraction, to investigate the integrity of treatment delivery compared to the nominal planned dose. The dosimetry-relevant log file parameters are used to reconstruct the 3D dose distribution on the patient anatomy, using a TPS-independent dose calculation system. The analysis was performed for patients treated at Paul Scherrer Institute on Gantry 2, both for individual fields and per series (or plan), and delivery quality was assessed by determining the percentage of voxels in the log file dose distribution within  +/-  1% of the nominal dose. It was seen that, for all series delivered, the mean pass rate is 96.4%. Furthermore, this work establishes a correlation between the delivery quality of a field and the beam position accuracy. This correlation is evident for all delivered fields regardless of individual patient or plan characteristics. We have also detailed further usefulness of log file analysis within our clinical workflow. In summary, we have highlighted that the integrity of PBS treatment delivery is dependent on daily machine performance and is specifically highly correlated with the accuracy of beam position. We believe this information will be useful for driving machine performance improvements in the PBS field.
authors.affiliation: Centre for Proton Therapy, Paul Scherrer Institute, 5232 Villigen, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Scandurra
authors.forename: F
authors.initials: F
authors.lastname: Albertini
authors.forename: R
authors.initials: R
authors.lastname: van der Meer
authors.forename: G
authors.initials: G
authors.lastname: Meier
authors.forename: D C
authors.initials: DC
authors.lastname: Weber
authors.forename: A
authors.initials: A
authors.lastname: Bolsi
authors.forename: A
authors.initials: A
authors.lastname: Lomax
mesh_terms: D006801:Humans; D061766:Proton Therapy / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D011787:Quality of Health Care; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*