title: E2F1: a promising regulator in ovarian carcinoma.
abstract: E2F is a family of transcription factors that recognized to regulate the expression of genes essential for a wide range of cellular functions, including cell cycle progression, DNA repair, DNA replication, differentiation, proliferation, and apoptosis. E2F1, the most classic member of the E2F family, exhibits a complex role in tumor development regulation. In recent years, a growing body of data suggested an intimate relationship between E2F1 and ovarian carcinoma. And E2F1 was well identified to play dual functions and serve as a useful prognostic indicator in ovarian carcinoma. However, the mechanism underlying E2F1 associated with ovarian carcinoma remains elusive. It is necessary to clarify the fundamental role of E2F1 in ovarian carcinoma. In this review, we tried to sum up the knowledge of E2F1, including its structure and related mechanism. We also attempt to absorb the research achievements and collect the mechanism of E2F1 in ovarian carcinoma.
authors.affiliation: Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhan
authors.affiliation: Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, China.
authors.forename: Enxue
authors.initials: E
authors.lastname: Song
authors.affiliation: Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, China. m1351565@163.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Wei
mesh_terms: D050687:E2F1 Transcription Factor / Q000737:chemistry / Q000502:physiology*; D005260:Female; D019398:Genes, BRCA1; D006801:Humans; D010051:Ovarian Neoplasms / Q000209:etiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
chemical_list: D050687:E2F1 Transcription Factor; C493753:E2F1 protein, human; D016159:Tumor Suppressor Protein p53
keywords: Cellular functions; E2F1; Ovarian carcinoma; Overlapping; Regulator