title: Photoassisted Diversity-Oriented Synthesis: Intramolecular Cycloadditions of Photogenerated Azaxylylenes with Oxazole Pendants, and Subsequent Postphotochemical Multicomponent Modifications.
abstract: Photogenerated aza-o-xylylenes undergo intramolecular cycloaddition reactions to tethered oxazoles, with primary photoproducts featuring a reactive cyclic imine moiety suitable for multicomponent postphotochemical transformations. For example, the reaction of these imine photoproducts with bromoacetyl bromide leads to a key 1,4-dielectrophilic synthon, offering access to diverse polyheterocyclic molecular architectures. This reaction sequence is accompanied by rapid growth complexity in a very few simple synthetic steps, and is in keeping with the philosophy of diversity-oriented synthesis (DOS).
authors.affiliation: Department of Chemistry and Biochemistry, University of Denver , Denver, Colorado 80208, United States.
authors.forename: N N Bhuvan
authors.initials: NN
authors.lastname: Kumar
authors.affiliation: Department of Chemistry and Biochemistry, University of Denver , Denver, Colorado 80208, United States.
authors.forename: Andrei G
authors.initials: AG
authors.lastname: Kutateladze