title: A general metal-free route towards the synthesis of 1,2,3-triazoles from readily available primary amines and ketones.
abstract: An unprecedented approach that enables the direct and selective preparation of 1,5-disubstituted 1,2,3-triazoles from abundantly available building blocks such as primary amines, enolizable ketones and 4-nitrophenyl azide as a renewable source of dinitrogen via an organocascade process has been developed. Furthermore, this efficient methodology also enables the synthesis of fully functionalized and fused N-substituted heterocycles.
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium. wim.dehaen@chem.kuleuven.be.
authors.forename: Joice
authors.initials: J
authors.lastname: Thomas
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium. wim.dehaen@chem.kuleuven.be.
authors.forename: Sampad
authors.initials: S
authors.lastname: Jana
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium. wim.dehaen@chem.kuleuven.be.
authors.forename: Jubi
authors.initials: J
authors.lastname: John
authors.affiliation: Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
authors.forename: Sandra
authors.initials: S
authors.lastname: Liekens
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium. wim.dehaen@chem.kuleuven.be.
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen