title: Statins as anti-cancer therapy; Can we translate preclinical and epidemiologic data into clinical benefit?
abstract: Statins, the most commonly prescribed class of drug, have demonstrated effects beyond cholesterol reduction including anti-tumor and immunomodulatory properties. Several epidemiological studies have suggested an anti-neoplastic effect of statins evidenced by reductions in cancer incidence and cancer-related mortality. Clinical trials on statins as part of therapy for cancer have generated interest in the oncology community. Statins have been investigated for a variety of cancers, early and late stage, and in combination with chemotherapy and radiation. So far promising results have been reported with statin use in pediatric brainstem tumors, early stage breast cancer, hepatocellular carcinoma (HCC), colorectal cancer (CRC), refractory or relapsed multiple myeloma (MM), and refractory acute myeloid leukemia (AML). There is still much investigation to be completed to determine which subtypes of patients benefit from statin therapy, how statins may potentiate other anticancer approaches, and the appropriate dosing schedule to use.
authors.affiliation: Northwestern Medicine Developmental Therapeutics Institute, Chicago, IL 60611, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.|Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Young Kwang
authors.initials: YK
authors.lastname: Chae
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Yousaf
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Mary-Kate
authors.initials: MK
authors.lastname: Malecek
authors.affiliation: Northwestern Medicine Developmental Therapeutics Institute, Chicago, IL 60611, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.|Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Benedito
authors.initials: B
authors.lastname: Carneiro
authors.affiliation: Northwestern Medicine Developmental Therapeutics Institute, Chicago, IL 60611, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.|Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Sunandana
authors.initials: S
authors.lastname: Chandra
authors.affiliation: Northwestern Medicine Developmental Therapeutics Institute, Chicago, IL 60611, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.|Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Kaplan
authors.affiliation: Northwestern Medicine Developmental Therapeutics Institute, Chicago, IL 60611, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.|Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Aparna
authors.initials: A
authors.lastname: Kalyan
authors.affiliation: Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.
authors.forename: Antonella
authors.initials: A
authors.lastname: Sassano
authors.affiliation: Northwestern Medicine Developmental Therapeutics Institute, Chicago, IL 60611, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.|Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.|Division of Hematology-Oncology, Department of Medicine, Jesse Brown VA Medical Center, Chicago, IL 60612, USA.
authors.forename: Leonidas C
authors.initials: LC
authors.lastname: Platanias
authors.affiliation: Northwestern Medicine Developmental Therapeutics Institute, Chicago, IL 60611, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.|Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Francis
authors.initials: F
authors.lastname: Giles
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D009367:Neoplasm Staging; D009369:Neoplasms / Q000188:drug therapy* / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy; D057170:Translational Research, Biomedical
chemical_list: D000970:Antineoplastic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors