title: Human Induced Pluripotent Stem Cells for Tumor Targeted Delivery of Gold Nanorods and Enhanced Photothermal Therapy.
abstract: How to improve effective accumulation and intratumoral distribution of plasmonic gold nanoparticles has become a great challenge for photothermal therapy of tumors. Herein, we reported a nanoplatform with photothermal therapeutic effects by fabricating Au nanorods@SiO2@CXCR4 nanoparticles and loading the prepared nanoparticles into the human induced pluripotent stem cells(AuNRs-iPS). In virtue of the prominent optical properties of Au nanorods@SiO2@CXCR4 and remarkable tumor target migration ability of iPS cells, the Au nanorods delivery mediated by iPS cells via the nanoplatform AuNRs-iPS was found to have a prolonged retention time and spatially even distribution in MGC803 tumor-bearing nude mice observed by photoacoustic tomography and two-photon luminescence. On the basis of these improvements, the nanoplatform displayed a robust migration capacity to target the tumor site and to improve photothermal therapeutic efficacy on inhibiting the growth of tumors in xenograft mice under a low laser power density. The combination of gold nanorods with human iPS cells as a theranostic platform paves an alternative road for cancer theranostics and holds great promise for clinical translation in the near future.
authors.forename: Yanlei
authors.initials: Y
authors.lastname: Liu
authors.forename: Meng
authors.initials: M
authors.lastname: Yang
authors.forename: Jingpu
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhi
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Chunlei
authors.initials: C
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Pan
authors.forename: Kan
authors.initials: K
authors.lastname: Wang
authors.forename: Yuming
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Instituto de Nanociencia de Aragon (INA), Universidad de Zaragoza , Zaragoza, 50018, Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Martinez de la Fuentea
authors.forename: Daxiang
authors.initials: D
authors.lastname: Cui
mesh_terms: D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D005260:Female; D006046:Gold / Q000737:chemistry; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000637:transplantation*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D043942:Nanotubes / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods*; D019718:Receptors, CXCR4 / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: C527276:CXCR4 protein, human; D019718:Receptors, CXCR4; D006046:Gold; D012822:Silicon Dioxide
keywords: Au nanorods; CXCR4; induced pluripotent stem cells; photothermal therapy