title: Association between Cytotoxic T-lymphocyte antigen 4 (CTLA-4) +49 G>A (rs231775) polymorphism and esophageal cancer: from a case-control study to a meta-analysis.
abstract: The aim of this study was to evaluate the association between CTLA-4 +49 G>A polymorphism and esophageal cancer (EC) susceptibility in a hospital based case-control study and a subsequent meta-analysis. We implemented genotyping analyses for CTLA-4 +49 G>A polymorphism with 629 esophageal squamous cell carcinoma cases and 686 controls in a Chinese Han population. Polymerase chain reaction ligase detection reaction (PCR-LDR) method was used to identify genotypes of CTLA-4 +49 G>A polymorphism. We first assessed the association between CTLA-4 +49 G>A polymorphism and EC risk in a hospital based case-control study, and then performed a comprehensive meta-analysis to derive a more precise estimation. Our results demonstrated that CTLA-4 +49 G>A polymorphism was not associated with EC risk. This case-control study and further meta-analysis, failed to identify the association between CTLA-4 +49 G>A polymorphism and EC risk. And additional, further well designed studies with large sample sizes and detailed gene-environment data are required.
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture Jinghong, Yunnan Province, China.
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Emergency, Affiliated Jintan People's Hospital of Jiangsu University Jintan, China.
authors.forename: Heping
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu UniversityZhenjiang, Jiangsu Province, China; Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical UniversityFuzhou, Fujian Province, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University Fuzhou, Fujian Province, China.
authors.forename: Shuchen
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University Fuzhou, Fujian Province, China.
authors.forename: Mingqiang
authors.initials: M
authors.lastname: Kang
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu Province, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Dong
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu Province, China.
authors.forename: Haiyong
authors.initials: H
authors.lastname: Gu
keywords: CTLA4; esophageal cancer; meta-analysis; polymorphism; susceptibility