title: Inferior frontal cortex activity is modulated by reward sensitivity and performance variability.
abstract: High reward sensitivity has been linked with motivational and cognitive disorders related with prefrontal and striatal brain function during inhibitory control. However, few studies have analyzed the interaction among reward sensitivity, task performance and neural activity. Participants (N=57) underwent fMRI while performing a Go/No-go task with Frequent-go (77.5%), Infrequent-go (11.25%) and No-go (11.25%) stimuli. Task-associated activity was found in inhibition-related brain regions, with different activity patterns for right and left inferior frontal gyri (IFG): right IFG responded more strongly to No-go stimuli, while left IFG responded similarly to all infrequent stimuli. Reward sensitivity correlated with omission errors in Go trials and reaction time (RT) variability, and with increased activity in right and left IFG for No-go and Infrequent-go stimuli compared with Frequent-go. Bilateral IFG activity was associated with RT variability, with reward sensitivity mediating this association. These results suggest that reward sensitivity modulates behavior and brain function during executive control.
authors.affiliation: Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Av. de Vicent Sos Baynat, s/n, 12071 Castelló de la Plana, Spain.
authors.forename: Paola
authors.initials: P
authors.lastname: Fuentes-Claramonte
authors.affiliation: Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Av. de Vicent Sos Baynat, s/n, 12071 Castelló de la Plana, Spain.
authors.forename: César
authors.initials: C
authors.lastname: Ávila
authors.affiliation: Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Av. de Vicent Sos Baynat, s/n, 12071 Castelló de la Plana, Spain.
authors.forename: Aina
authors.initials: A
authors.lastname: Rodríguez-Pujadas
authors.affiliation: Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Av. de Vicent Sos Baynat, s/n, 12071 Castelló de la Plana, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Costumero
authors.affiliation: Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Av. de Vicent Sos Baynat, s/n, 12071 Castelló de la Plana, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Ventura-Campos
authors.affiliation: Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Av. de Vicent Sos Baynat, s/n, 12071 Castelló de la Plana, Spain; Departamento de Psicología y Sociología, Facultad de Educación, Universidad de Zaragoza, Doctor Cerrada, 1-3, 50005 Zaragoza, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Bustamante
authors.affiliation: Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Av. de Vicent Sos Baynat, s/n, 12071 Castelló de la Plana, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Rosell-Negre
authors.affiliation: Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Av. de Vicent Sos Baynat, s/n, 12071 Castelló de la Plana, Spain. Electronic address: barros@uji.es.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Barrós-Loscertales
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D003071:Cognition / Q000502:physiology; D056344:Executive Function / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D064368:Healthy Volunteers; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011930:Reaction Time / Q000502:physiology*; D012201:Reward; D013647:Task Performance and Analysis; D055815:Young Adult
keywords: Executive function; Individual differences; Prefrontal cortex; Response inhibition; fMRI