title: [Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines].
abstract: Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity starting from commercially available R- and S-isomers of N-Boc-2-aminopropanol-1. Application of R- and S-isomers of 3-MeSpd for the investigation of the stereospecificity of spermidine transporter and peculiarities of deoxyhypusine synthase reaction are discussed.
authors.forename: M A
authors.initials: MA
authors.lastname: Khomutov
authors.forename: T A
authors.initials: TA
authors.lastname: Keinanen
authors.forename: M T
authors.initials: MT
authors.lastname: Hyvonen
authors.forename: J
authors.initials: J
authors.lastname: Weisell
authors.forename: J
authors.initials: J
authors.lastname: Vepsalainen
authors.forename: L
authors.initials: L
authors.lastname: Alhonen
authors.forename: S N
authors.initials: SN
authors.lastname: Kochetkov
authors.forename: A R
authors.initials: AR
authors.lastname: Khomutov
mesh_terms: D002384:Catalysis; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000737:chemistry; D013095:Spermidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D000587:Oxidoreductases Acting on CH-NH Group Donors; C063507:deoxyhypusine synthase; D013095:Spermidine