title: First Evidence that Sika Deer (Cervus nippon) Velvet Antler Extract Suppresses Migration of Human Prostate Cancer Cells.
abstract: Deer velvet antler (DVA) is one of the most popular medicines in China. Numerous studies have demonstrated that velvet antler possess biological effects. However, data regarding its anti-migration activity on prostate cancer is scarce. In this study, we investigated the inhibitory effect of top DVA (T-DVA) on the expression of prostate-specific antigen (PSA) and migration-related genes in the human prostate cancer cell, LNCaP. The T-DVA down-regulated the expression of PSA. In addition, the Radius(TM) assay revealed that T-DVA inhibited the migration behavior of prostate cancer cells. Furthermore, the expression of matrix metalloproteinase (MMP)-9 and vascular endothelial growth factor (VEGF) was also decreased with T-DVA. On the contrary, T-DVA increased the tissue inhibition of metalloproteinase (TIMP)-1 and (TIMP)-2. Taken together, our findings indicate that the T-DVA possesses anti-migration activity on prostate cancer cells. This is the first study of DVA to report the anti-migration activity on prostate cancer.
authors.affiliation: Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University, Chungju 380-701, Korea ; Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Korea; Jilin Sino-Rok Institute of Animal Science, Changchun 130-600, China.
authors.forename: YuJiao
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University, Chungju 380-701, Korea ; Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Korea.
authors.forename: Byong-Tae
authors.initials: BT
authors.lastname: Jeon
authors.affiliation: Jilin Sino-Rok Institute of Animal Science, Changchun 130-600, China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Division of Sport Science, College of Biomedical and Health Sciences, Konkuk University, Chungju 380-701, Korea.
authors.forename: Eun-Ju
authors.initials: EJ
authors.lastname: Choi
authors.affiliation: Department of Biotechnology, Konkuk University, Chungju 380-701, Korea.
authors.forename: Yon-Suk
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Biotechnology, Konkuk University, Chungju 380-701, Korea.
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Hwang
authors.affiliation: Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Korea; Department of Biotechnology, Konkuk University, Chungju 380-701, Korea.
authors.forename: Pyo-Jam
authors.initials: PJ
authors.lastname: Park
authors.affiliation: Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University, Chungju 380-701, Korea ; Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Korea.
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Moon
authors.affiliation: Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University, Chungju 380-701, Korea ; Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Korea.
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Kim
keywords: Deer velvet antler; PSA; migration; prostate cancer