title: Coexistence of blaOXA-23 with armA in quinolone-resistant Acinetobacter baumannii from a Chinese university hospital.
abstract: A total of 101 Acinetobacter baumannii isolates were collected to determine the mechanisms of quinolone resistance and investigate the occurrence of carbapenem and high-level aminoglycoside resistance genes among quinolone-resistant strains. Among 77 quinolone-resistant A. baumannii harbored mutations of gyrA and parC, 41 isolates, which belonged to European clone II, had resistance to aminoglycosides and carbapenems due to the expression of armA and acquisition of blaOXA-23. Most of sequence type belonged to clonal complex 92. These results suggested hospital dissemination of multidrug-resistant A. baumannii carrying blaOXA-23, armA, and mutations of quinolone resistance-determining regions in western China.
authors.affiliation: Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu 610500, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Shen
authors.affiliation: Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu 610500, PR China.
authors.forename: Guangxin
authors.initials: G
authors.lastname: Luan
authors.affiliation: Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu 610500, PR China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Small Molecule Drugs Key Laboratory of Sichuan Province, Institute of Materia Medica, Chengdu Medical College, Chengdu 610500, PR China.
authors.forename: Yaowen
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Small Molecule Drugs Key Laboratory of Sichuan Province, Institute of Materia Medica, Chengdu Medical College, Chengdu 610500, PR China.
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu 610500, PR China.
authors.forename: Jingni
authors.initials: J
authors.lastname: Yang
authors.affiliation: School of Laboratory Medicine, Chengdu Medical College, Chengdu 610500, PR China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Deng
authors.affiliation: Small Molecule Drugs Key Laboratory of Sichuan Province, Institute of Materia Medica, Chengdu Medical College, Chengdu 610500, PR China. Electronic address: lingbaodong@cmc.edu.cn.
authors.forename: Baodong
authors.initials: B
authors.lastname: Ling
authors.affiliation: Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu 610500, PR China. Electronic address: jiaxu@cmc.edu.cn.
authors.forename: Xu
authors.initials: X
authors.lastname: Jia
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D002681:China; D003428:Cross Infection; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D006785:Hospitals, University; D006801:Humans; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D009154:Mutation; D010802:Phylogeny; D015363:Quinolones / Q000494:pharmacology*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015363:Quinolones; D001618:beta-Lactamases; C000599728:beta-lactamase OXA-23, Acinetobacter baumannii
keywords: Acinetobacter baumannii; Multi-drug resistant; Quinolone; armA; bla(OXA-23)