title: Movement impairment: Focus on the brain.
abstract: The saying "mens sana in corpore sano" has a particular resonance these days because, for the majority who have a very sedentary occupation, the everyday rhythms of life do not compel us to do much physical exercise. Recently published data indicate that exercise can counteract the effects of neurological diseases such as Alzheimer's disease and have prompted research on the beneficial effects of movement on the brain and brain neurogenesis. This might lead us to hypothesize that the absence or reduction of movements, especially those with antigravity effects, could induce a deterioration of the brain. This Review discusses current knowledge of the relationship between neurogenic capacity and the lack of motor activity in human and animal models.
authors.affiliation: Department of Health Science, Faculty of Medicine, University of Milan, Milan, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Adami
authors.affiliation: Department of Health Science, Faculty of Medicine, University of Milan, Milan, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Bottai
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*
keywords: bed rest; hindlimb unloading; neurogenesis; trophic factors