title: Identification of plasma vascular endothelia-cadherin as a biomarker for coronary artery disease in Type 2 diabetes mellitus patients.
abstract: OBJECTIVE
  To examine how vascular endothelia (VE)-cadherin plasma levels are correlated with parameters associated with endothelial function such as endothelin-1, nitric oxide, nitric oxide synthase and HbA1c in type 2 diabetic patients with coronary artery disease.
  
  
  METHODS
  VE-cadherin levels were analyzed by enzyme-linked immunosorbent assays. Spearman's correlation and multiple stepwise regression analyses were used to examine the relationship between plasma VE-cadherin and other factors.
  
  
  RESULTS
  By univariate correlation analysis, plasma VE-cadherin levels were significantly associated with age, total cholesterol, triglyceride, hemoglobin A1c, and endothelin-1. Multiple regression analysis (adjusted for age, total cholesterol, and triglyceride) showed that plasma VE-cadherin levels were independently and significantly associated with HbA1c and ET-1. Plasma VE-cadherin levels were significantly highest in patients with diabetes mellitus and coronary artery disease. While patients with diabetes mellitus had higher levels of VE-cadherin compared with healthy subjects.
  
  
  CONCLUSIONS
  This study found that VE-cadherin levels might be a biomarker for some endothelial dysfunction associated with coronary artery disease in type 2 diabetes mellitus.
authors.affiliation: Department of Endocrinology, The Second Artillary General Hospital of Chinese People's Liberation Army Beijing 100088, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Endocrinology, The Second Artillary General Hospital of Chinese People's Liberation Army Beijing 100088, China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Chang
authors.affiliation: Department of Endocrinology, The Second Artillary General Hospital of Chinese People's Liberation Army Beijing 100088, China.
authors.forename: Quanmin
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Endocrinology, The Second Artillary General Hospital of Chinese People's Liberation Army Beijing 100088, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Endocrinology, The Second Artillary General Hospital of Chinese People's Liberation Army Beijing 100088, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, The Second Artillary General Hospital of Chinese People's Liberation Army Beijing 100088, China.
authors.forename: Ruiqin
authors.initials: R
authors.lastname: Du
authors.affiliation: Department of Endocrinology, The Second Artillary General Hospital of Chinese People's Liberation Army Beijing 100088, China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Hu
keywords: Vascular endothelia-cadherin; coronary artery disease; type 2 diabetes mellitus