title: The association between phospholipase C epsilon gene (PLCE1) polymorphisms and colorectal cancer risk in a Chinese Han population: a case-control study.
abstract: BACKGROUND
  Heritable factors contribute to the development of colorectal cancer (CRC). We investigated the association between single nucleotide polymorphisms in phospholipase C epsilon 1 (PLCE1) and CRC susceptibility.
  
  
  METHODS
  We selected eight tag single nucleotide polymorphisms (tSNPs) and investigated whether they were associated with CRC in Chinese Han population. In this study, we used Sequenom MassARRAY technology and genotyped 276 CRC cases and 385 controls. The effects of the polymorphisms on the risk of CRC were expressed as odds ratios (ORs) with 95% confidence intervals (95% CIs), evaluated by different genetic models using unconditional logistic regression analysis adjusted for age and gender. We also analyzed the risk of the eight PLCE1 tSNPs in different histology of CRC.
  
  
  RESULTS
  Based on x(2) tests, rs753724 (OR = 1.49, 95% CI: 1.10-2.03, P = 0.010) and rs10882424 (OR = 1.32, 95% CI: 1.02-1.70, P = 0.037) in PLCE1 were associated with CRC. In genetic model analyses, we found that rs753724 in PLCE1 may increase CRC risk (OR = 1.48, 95% CI: 1.09-2.03, P = 0.013) in the log-additive model, and rs11187842 in PLCE1 may increase CRC risk (OR = 3.09, 95% CI: 1.17-8.14, P = 0.018) in the recessive model. Rs753724 TT (OR = 4.31, P = 0.010), rs11187842 TT (OR = 5.78, P = 0.003), and rs10882424 GG (OR = 2.64, P = 0.022) in PLCE1 may increase rectal cancer in a recessive model.
  
  
  CONCLUSIONS
  Our results suggest that PLCE1 may be associated with CRC in Han Chinese population.
authors.affiliation: Department of General Surgery, Yulin First Hospital Yulin 718000, China.
authors.forename: Yongwang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of the Medical Section, Yulin First Hospital Yulin 718000, China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Gong
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi, China.
authors.forename: Shuli
authors.initials: S
authors.lastname: Du
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi, China.
authors.forename: Mengdan
authors.initials: M
authors.lastname: Yan
authors.affiliation: National Engineering Research Center for Miniaturized Detection SystemsXi'an 710069, Shaanxi, China; Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of MedicineXi'an 710061, Shaanxi, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Geng
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Feng
authors.affiliation: First Department of General Surgery, The Fourth Hospital of Yulin Yulin 719000, China.
authors.forename: Jianrui
authors.initials: J
authors.lastname: Wang
authors.affiliation: National Engineering Research Center for Miniaturized Detection SystemsXi'an 710069, Shaanxi, China; School of Life Sciences, Northwest UniversityXi'an 710069, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
keywords: Phospholipase C epsilon 1; case-control; colorectal cancer; single nucleotide polymorphism