title: Multiple nodules on the sole of the foot.
abstract: Ledderhose disease, or plantar fibromatosis, is a benign hyperproliferative disorder of the plantar aponeurosis. It presents as one or more round, firm slow-growing plaques or nodules on the plantar surface of the foot, typically on the medial side. The etiology is unknown, though it has been associated with trauma, liver disease, diabetes mellitus, epilepsy and alcoholism. Histopathological examination of plantar fibromatosis reveals dense fibrocellular tissue with parallel and nodular arrays of fibrocytes and fibrillar collagen with a distinctive cork-screw morphology. The differential diagnosis includes various fibroblastic and myofibroblastic proliferations.
authors.affiliation: NYIT-College of Osteopathic Medicine, New York, USA.
authors.forename: Alyssa J
authors.initials: AJ
authors.lastname: Miceli
authors.affiliation: Ackerman Academy of Dermatopathology, New York, USA.
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Junkins-Hopkins
authors.affiliation: Polley Clinic, Wilson, North Carolina, USA.
authors.forename: Dennis C
authors.initials: DC
authors.lastname: Polley
authors.affiliation: Ackerman Academy of Dermatopathology, New York, USA.
authors.forename: Dirk M
authors.initials: DM
authors.lastname: Elston
keywords: Ledderhose disease; Plantar fibromatosis; Superficial fibromatosis