title: Human amniotic membrane grafts in therapy of chronic non-healing wounds.
abstract: BACKGROUND
  Human amniotic membrane (HAM) has been embraced as a natural wound dressing almost exclusively in ophthalmology. Only recently, emergence of commercial HAM products prompted its use in growing range of indications, especially treatment of chronic non-healing wounds.
  
  
  METHODS
  ClinicalTrials.gov database and International Clinical Trials Registry Platform searched with key words 'human amniotic membrane' and 'chronic wounds'.
  
  
  RESULTS
  HAM can be successfully used as a natural wound dressing to promote healing.
  
  
  RESULTS
  It is still unclear, which preparation is more advantageous, cryopreserved HAM or dehydrated HAM.
  
  
  CONCLUSIONS
  There are an increasing number of commercial HAM products and clinical trials for a variety of dermatological diagnoses.
  
  
  CONCLUSIONS
  In spite of easy procurement and low production costs, to our knowledge, there are currently only a few manufacturers of commercial HAM products tested in clinical trials for cutaneous wounds and all of them are located in the USA.
authors.affiliation: Stem Cell Laboratories, Guy's Assisted Conception Unit, Division of Women's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK dusko.ilic@kcl.ac.uk.
authors.forename: Dusko
authors.initials: D
authors.lastname: Ilic
authors.affiliation: Laboratory for Biology of Reproduction, Institute INEP, University of Belgrade, Banatska 31b, Zemun, Belgrade 11080, Serbia.
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Vicovac
authors.affiliation: Division of Pediatric Dermatology, Department of Dermatovenereology, Faculty of Medicine, University of Belgrade, Pasterova 2, Belgrade 11000, Serbia.
authors.forename: Milos
authors.initials: M
authors.lastname: Nikolic
authors.affiliation: Bone Marrow Transplantation Unit, Laboratory for Cryobiology, Mother and Child Healthcare Institute, Belgrade, Serbia.
authors.forename: Emilija
authors.initials: E
authors.lastname: Lazic Ilic
mesh_terms: D000650:Amnion / Q000637:transplantation*; D001684:Biological Dressings; D002908:Chronic Disease / Q000628:therapy; D002986:Clinical Trials as Topic; D017719:Diabetic Foot / Q000628:therapy; D006801:Humans; D007871:Leg Ulcer / Q000628:therapy; D012867:Skin / Q000293:injuries*; D017768:Skin, Artificial; D014945:Wound Healing / Q000502:physiology*
keywords: burns; chronic wounds; diabetic foot ulcer; human amniotic membrane; natural wound dressing; recessive dystrophic epidermolysis bullosa