title: Construction and Validation of Brain MRI Templates from a Korean Normal Elderly Population.
abstract: OBJECTIVE
  This study aimed to construct a Korean normal elderly brain template (KNE96) using Korean elderly individuals for use in brain MRI studies and to validate it.
  
  
  METHODS
  We used high-resolution 3.0T T1 structural MR images from 96 Korean normal elderly individuals (M/F=48/48), aged 60 years or older (M=69.5±6.2 years, F=70.1±7.0 years), for constructing the KNE96 template. The KNE96 template was validated by comparing the registration-induced deformations between the KNE96 and ICBM152 templates using different MR images from 48 Korean normal elderly individuals (M/F=24/24), aged 60 years or older (M=71.5±5.9 years, F=72.8±5.1 years). We used the magnitude of displacement vectors (mag-displacement) and log of Jacobian determinants (log-Jacobian) to quantify the deformation produced during registration process to templates.
  
  
  RESULTS
  The mag-displacement and log-Jacobian of the registration were much smaller using the KNE96 template than with the ICBM152 template in most brain regions. There was a prominent difference in the significant averaged differences (SADs) of the mag-displacement and log-Jacobian between the KNE96 and ICBM152 at the superior, medial, and middle frontal gyrus, the lingual, inferior, middle, and superior occipital gyrus, and the caudate and thalamus.
  
  
  CONCLUSIONS
  This study suggests that templates constructed from Asian populations, such as the KNE96, may be more desirable than those from Caucasian populations, like the ICBM152, in computational neuroimaging studies that measure and compare anatomical features of the frontal and occipital lobe, thalamus and caudate.
authors.affiliation: Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
authors.forename: Hyunna
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors.forename: Byung Il
authors.initials: BI
authors.lastname: Yoo
authors.affiliation: Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Han
authors.affiliation: Department of Psychiatry, Dankook University Medical College, Cheonan, Republic of Korea.
authors.forename: Jung Jae
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors.forename: San Yeo Wool
authors.initials: SY
authors.lastname: Oh
authors.affiliation: Department of Psychiatry, Dankook University Medical College, Cheonan, Republic of Korea.
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Lee
authors.affiliation: Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors.forename: Jae Hyoung
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.; Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Ki Woong
authors.initials: KW
authors.lastname: Kim
keywords: Brain template; Elderly; Korean; Magnetic resonance imaging