title: Experimental validation of more realistic computer models for stent-graft repair of abdominal aortic aneurysms, including pre-load assessment.
abstract: Although the endovascular repair of abdominal aortic aneurysms is a less invasive alternative than classic open surgery, complications such as endoleak and kinking still need to be addressed. Numerical simulation of endovascular repair is becoming a valuable tool in stent-graft (SG) optimization, patient selection and surgical planning. The experimental and numerical forces required to produce SG deformations were compared in a range of in vivo conditions in the present study. The deformation modes investigated were: bending as well as axial, transversal and radial compressions. In particular, an original method was developed to efficiently account for radial pre-load because of the pre-compression of stents to match the graft dimensions during manufacturing. This is important in order to compute the radial force exerted on the vessel after deployment more accurately. Variations of displacement between the experimental and numerical results ranged from 1.39% for simple leg bending to 5.93% for three-point body bending. Finally, radial pre-load was modeled by increasing Young's modulus of each stent. On average, it was found that Young's modulus had to be augmented by a factor of 2. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Centre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada, H2X 0A9.|Biomedical Engineering Institute, Université de Montréal, Montréal, Québec, Canada, H3T 1J4.
authors.forename: David
authors.initials: D
authors.lastname: Roy
authors.affiliation: Centre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada, H2X 0A9.|Department of Mechanical Engineering, École de Technologie Supérieure, Montréal, Québec, Canada, H3C 1K3.|Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montréal, Québec, Canada, H3C 3J7.
authors.forename: Sophie
authors.initials: S
authors.lastname: Lerouge
authors.affiliation: Department of Mechanical Engineering, École de Technologie Supérieure, Montréal, Québec, Canada, H3C 1K3.
authors.forename: Karina
authors.initials: K
authors.lastname: Inaekyan
authors.affiliation: Centre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada, H2X 0A9.
authors.forename: Claude
authors.initials: C
authors.lastname: Kauffmann
authors.affiliation: Department of Mechanical Engineering, McGill University, Montréal, Québec, Canada, H3A 0C3.
authors.forename: Rosaire
authors.initials: R
authors.lastname: Mongrain
authors.affiliation: Centre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada, H2X 0A9.|Biomedical Engineering Institute, Université de Montréal, Montréal, Québec, Canada, H3T 1J4.|Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montréal, Québec, Canada, H3C 3J7.
authors.forename: Gilles
authors.initials: G
authors.lastname: Soulez
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D003198:Computer Simulation; D055119:Elastic Modulus; D020342:Finite Element Analysis; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D015607:Stents
keywords: aneurysm; computation; finite element analysis; pre-load; stent-graft