title: Intraventricular Glioblastomas.
abstract: BACKGROUND
  Although glioblastoma is the most common primary brain tumor, primary intraventricular locations are extremely rare; only 21 cases have been reported to date.
  
  
  METHODS
  A retrospectively acquired database of all intracranial glioblastomas treated in 2 different neurosurgical departments during the last 10 years was queried. Patients with histologically proven intraventricular glioblastomas were included in the study.
  
  
  RESULTS
  Eight patients were identified as having a histologically confirmed intraventricular glioblastoma. Patient age at diagnosis ranged from 6 to 74 years (mean 29.6 years) and the male/female ratio was 5:3. Increased intracranial pressure due to hydrocephalus was the main cause of the clinical manifestations. The tumor was located within the lateral ventricle in 6 cases and the anterior third ventricle in 2 others. Gross total tumor excision was achieved in 3 patients, whereas the surgical resection was subtotal in 4 cases and a surgical biopsy was performed in 1 patient. Postoperative adjuvant therapies were administered in 5 patients. Median survival time was 32.1 months, and 3 patients were alive at the end of study. All of them had isocitrate dehydrogenase-mutated tumors.
  
  
  CONCLUSIONS
  Intraventricular glioblastoma is extremely rare and can affect younger individuals including children. This malignant tumor should be included in the differential diagnosis of intraventricular lesions, especially in the lateral ventricles. Radical surgical resection can be associated with remarkable disease-free survival, especially in isocitrate dehydrogenase-mutated tumors. Because recurrence virtually is unavoidable, long-term follow-up is mandatory.
authors.affiliation: Department of Neurosurgery, Fattouma Bourguiba University Hospital-University of Medicine of Monastir, Monastir, Tunisia. Electronic address: atefbn@hotmail.fr.
authors.forename: Atef
authors.initials: A
authors.lastname: Ben Nsir
authors.affiliation: Department of Neurosurgery, The Tunisian National Institute of Neurology-Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: Yassine
authors.initials: Y
authors.lastname: Gdoura
authors.affiliation: Department of Neurosurgery, The Johns Hopkins Hospital-The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Quoc-Anh
authors.initials: QA
authors.lastname: Thai
authors.affiliation: Department of pathology, La Rabta University Hospital-Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: Alia
authors.initials: A
authors.lastname: Zhani Kassar
authors.affiliation: Department of Neurosurgery, Fattouma Bourguiba University Hospital-University of Medicine of Monastir, Monastir, Tunisia.
authors.forename: Nejib
authors.initials: N
authors.lastname: Hattab
authors.affiliation: Department of Neurosurgery, The Tunisian National Institute of Neurology-Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: Hafedh
authors.initials: H
authors.lastname: Jemel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002551:Cerebral Ventricle Neoplasms / Q000473:pathology* / Q000601:surgery*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005909:Glioblastoma / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D035583:Rare Diseases / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: Chemotherapy; Glioblastoma; Intraventricular tumors; Radiotherapy; Transcallosal approach; Transcortical approach