title: New C-methylated flavonoids and α-pyrone derivative from roots of Talinum triangulare growing in Nigeria.
abstract: The first chemical examination of roots of the traditionally used medicinal plant Talinum triangulare (Portulacaceae) from Nigeria led to the isolation of two new C-methylated flavonoids, 5,6-dimethoxy-7-hydroxy-8-methyl-flavone (1), 5,6-dimethoxy-8-methyl-2-phenyl-7H-1-benzopyran-7-one (2), and one new α-pyrone derivative, 4-methoxy-6-(2-hydroxy-4-phenylbutyl)-2H-pyran-2-one (3), along with thirteen known compounds, including nine amides (4-12), indole-3-carboxylic acid (13), p-hydroxy benzoic acid (14), and two steroids (15-16). Their structures were elucidated by extensive spectroscopic measurements including 1D, 2D NMR, MS, and by comparison with the literature. All isolated compounds were screened for their cytotoxic and antifungal activities. However, none of them showed significant activity.
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany; Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka, Nigeria.
authors.forename: Blessing O
authors.initials: BO
authors.lastname: Umeokoli
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
authors.forename: Rini
authors.initials: R
authors.lastname: Muharini
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka, Nigeria.
authors.forename: Festus B
authors.initials: FB
authors.lastname: Okoye
authors.affiliation: Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, Awka, Nigeria.
authors.forename: Vincent I
authors.initials: VI
authors.lastname: Ajiwe
authors.affiliation: Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, Awka, Nigeria.
authors.forename: Mabel U
authors.initials: MU
authors.lastname: Akpuaka
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 100191 Beijing, China.
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. Electronic address: zhenfeizi0@sina.com.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. Electronic address: proksch@uni-duesseldorf.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D051379:Mice; D015394:Molecular Structure; D009549:Nigeria; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D029622:Portulacaceae / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D005419:Flavonoids; D011753:Pyrones
keywords: Amides; C-methylated flavonoids; Talinum triangulare; α-pyrone