title: Singapore Cancer Network (SCAN) Guidelines for Systemic Therapy of High-Grade Glioma.
abstract: BACKGROUND
  The SCAN Neuro-Oncology workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines for systemic therapy for high-grade glioma in Singapore.
  
  
  METHODS
  The workgroup utilised a modified ADAPTE process to calibrate high quality international evidence-based clinical practice guidelines to our local setting.
  
  
  RESULTS
  Six international guidelines were evaluated- those developed by the National Comprehensive Cancer Network (2013), the European Association for Neuro-Oncology (EANO) Task Force on Malignant Glioma (2014), the European Society of Medical Oncology (2014), the Canadian GBM Recommendations Committee (2007) and the Australian Cancer Network (2009). Recommendations on the systemic therapy of high-grade glioma were produced.
  
  
  CONCLUSIONS
  These adapted guidelines form the SCAN Guidelines 2015 for systemic therapy of high-grade glioma.
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001254:Astrocytoma / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D000068258:Bevacizumab / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D016190:Carboplatin / Q000008:administration & dosage; D059248:Chemoradiotherapy; D017024:Chemotherapy, Adjuvant; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005909:Glioblastoma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D000077146:Irinotecan; D008130:Lomustine; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D009837:Oligodendroglioma / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D011344:Procarbazine; D011878:Radiotherapy; D012846:Singapore; D000077204:Temozolomide; D013713:Teniposide / Q000008:administration & dosage; D014750:Vincristine
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D011344:Procarbazine; D014750:Vincristine; C501466:nimotuzumab; D000077146:Irinotecan; D008130:Lomustine; D003606:Dacarbazine; D003520:Cyclophosphamide; D013713:Teniposide; D016190:Carboplatin; D002166:Camptothecin; D000077204:Temozolomide