title: Helicobacter pylori infection in dyspeptic patients in an industrial belt of India.
abstract: The present study is done to study different aspects of Helicobacter pylori (H. pylori) such as its prevalence, association with upper gastrointestinal pathology, diagnosis and treatment outcome. Gastric antral biopsy and serology for H. pylori was done for all dyspeptic patients. Histopathology, gram stain and biopsy urease test was done from the gastric biopsy specimen. The prevalence of H. pylori infection was 58.8%. The sensitivity, specificity, positive and negative predictive value for histopathology was 96.9%, 100%, 100% and 95.8%, respectively; for biopsy urease test 80.4%, 100%, 100% and 78.2%, respectively; for gram stain 85.6%, 97.1%, 97.6% and 82.5%, respectively, and for serology 94.8%, 77.9%, 86% and 91.4%, respectively. Mostly peptic ulcer and duodenitis cases followed by chronic active gastritis were associated with H. pylori infection. Repeat biopsy revealed eradication of H. pylori in 90.7% cases. In dyspeptic patients, endoscopic biopsy not only detects H. pylori infection, but also reveals different gastric pathologies.
authors.affiliation: Associate Professor, Midnapore Medical College and Hospital, Midnapore, West Bengal, India.
authors.forename: Parthasarathi
authors.initials: P
authors.lastname: Satpathi
authors.affiliation: Senior Director, Ispat General Hospital, Rourkela, Odisha, India Sanghamitra.satpathi@gmail.com.
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Satpathi
authors.affiliation: Senior Consultant, CWS Hospital, Rourkela, Odisha, India.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Mohanty
authors.affiliation: Dean, Asian Institute of Public Health, Bhubaneswar, Odisha, India.
authors.forename: Saroj K
authors.initials: SK
authors.lastname: Mishra
authors.affiliation: Senior Director, Ispat General Hospital, Rourkela, Odisha, India.
authors.forename: Prativa K
authors.initials: PK
authors.lastname: Behera
authors.affiliation: RMO, Midnapore Medical College and Hospital, Midnapore, India.
authors.forename: Amit Bikram
authors.initials: AB
authors.lastname: Maity
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D004415:Dyspepsia / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D005260:Female; D005756:Gastritis / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology; D005843:Geography; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Dyspepsia; Helicobacter pylori (H. pylori); endoscopic biopsy; gastritis