title: Genetic polymorphisms associated with heart failure: A literature review.
abstract: OBJECTIVE
  To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure.
  
  
  METHODS
  Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and February 2015.
  
  
  RESULTS
  Eighty-two articles covering 29 genes and 39 polymorphisms were identified.
  
  
  CONCLUSIONS
  Genetic association studies of heart failure have been highly controversial. There may be interaction or synergism of several genetic variants that together result in the ultimate pathological phenotype for heart failure.
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Mengqi
authors.initials: M
authors.lastname: Guo
authors.affiliation: Hubei Key Laboratory of Advanced Technology of Automotive Components, School of Automotive Engineering, Wuhan University of Technology, Wuhan, China.
authors.forename: Guanlun
authors.initials: G
authors.lastname: Guo
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China jxp1964@hotmail.com.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Ji
mesh_terms: D004843:Epistasis, Genetic; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006333:Heart Failure / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis
keywords: Heart failure; genetic polymorphism; prognosis; susceptibility; therapy