title: Non-dioxin-like Polychlorinated Biphenyls (PCBs) and Chlordecone Release from Adipose Tissue to Blood in Response to Body Fat Mobilization in Ewe (Ovis aries).
abstract: Understanding how persistent organic pollutants (POPs) are released from adipose tissue (AT) to blood is a critical step in proposing rearing strategies hastening the removal of POPs from contaminated livestock. The current study aimed to determine in nonlactating ewes whether polychlorinated biphenyls (PCBs) and chlordecone are released from AT to blood along with lipids during body fat mobilization achieved through β-agonist challenges or undernutrition. β-Agonist challenges did not affect serum POP concentrations, whereas serum PCBs 138, 153, and 180 were readily increased in response to undernutrition. After 21 days of depuration in undernutrition, AT PCB 153 and 180 concentrations were increased concomitantly with a decrease in adipocyte volume, whereas AT chlordecone concentration was not different from that observed at the end of the well-fed contamination period. Thus, undernutrition may be of practical relevance for accelerating POP depuration unless it is combined with a strategy increasing their excretion pool.
authors.affiliation: Université de Lorraine, EA 3998, INRA, USC 340, UR Animal et Fonctionnalités des Produits Animaux, TSA 40602 , F-54518 Vandœuvre-lès-Nancy, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Lerch
authors.affiliation: Université de Lorraine, EA 3998, INRA, USC 340, UR Animal et Fonctionnalités des Produits Animaux, TSA 40602 , F-54518 Vandœuvre-lès-Nancy, France.
authors.forename: Côme
authors.initials: C
authors.lastname: Guidou
authors.affiliation: Laboratoire d'Ecologie Animale et d'Ecotoxicologie, Center for Analytical and Research Technology, Université de Liège , B-4000 Sart-Tilman, Liège, Belgium.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Thomé
authors.affiliation: Université de Lorraine, EA 3998, INRA, USC 340, UR Animal et Fonctionnalités des Produits Animaux, TSA 40602 , F-54518 Vandœuvre-lès-Nancy, France.
authors.forename: Stefan
authors.initials: S
authors.lastname: Jurjanz
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D007631:Chlordecone / Q000097:blood / Q000378:metabolism*; D004785:Environmental Pollutants / Q000097:blood / Q000378:metabolism*; D005223:Fats / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000378:metabolism*; D012756:Sheep / Q000097:blood / Q000378:metabolism*
chemical_list: D004785:Environmental Pollutants; D005223:Fats; D011078:Polychlorinated Biphenyls; D007631:Chlordecone
keywords: body fat mobilization; chlordecone; ewe; non-dioxin-like polychlorinated biphenyls; undernutrition; β-agonist