title: Tool use in left brain damage and Alzheimer's disease: What about function and manipulation knowledge?
abstract: Tool use disorders are usually associated with difficulties in retrieving function and manipulation knowledge. Here, we investigate tool use (Real Tool Use, RTU), function (Functional Association, FA) and manipulation knowledge (Gesture Recognition, GR) in 17 left-brain-damaged (LBD) patients and 14 AD patients (Alzheimer disease). LBD group exhibited predicted deficit on RTU but not on FA and GR while AD patients showed deficits on GR and FA with preserved tool use skills. These findings question the role played by function and manipulation knowledge in actual tool use.
authors.affiliation: Laboratory of Psychology LPPL (EA 4638), University of Angers, France.
authors.forename: Christophe
authors.identifier: http://orcid.org/0000-0002-2359-2980
authors.initials: C
authors.lastname: Jarry
authors.affiliation: Laboratory for the Study of Cognitive Mechanisms (EA 3082), University of Lyon, France.|French Universitary Institute, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Osiurak
authors.affiliation: Laboratory of Psychology LPPL (EA 4638), University of Angers, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Besnard
authors.affiliation: Laboratory of Psychology LPPL (EA 4638), University of Angers, France.
authors.forename: Josselin
authors.initials: J
authors.lastname: Baumard
authors.affiliation: Laboratory for the Study of Cognitive Mechanisms (EA 3082), University of Lyon, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lesourd
authors.affiliation: Neuropsychological Unit, Neurological Hospital Pierre Wertheimer, Bron, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Croisile
authors.affiliation: Laboratory of Psychology LPPL (EA 4638), University of Angers, France.|Department of Neurology, University Hospital of Angers, France.|Neuropsychological Unit, Department of Neurology, University Hospital of Angers, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Etcharry-Bouyx
authors.affiliation: Department of Neurology, University Hospital of Angers, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Chauviré
authors.affiliation: Laboratory of Psychology LPPL (EA 4638), University of Angers, France.|Department of Neurology, University Hospital of Angers, France.|Neuropsychological Unit, Department of Neurology, University Hospital of Angers, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Le Gall
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology* / Q000523:psychology*; D001072:Apraxias / Q000150:complications / Q000473:pathology* / Q000523:psychology*; D005260:Female; D007839:Functional Laterality; D005868:Gestures; D006801:Humans; D008297:Male; D011597:Psychomotor Performance; D021641:Recognition, Psychology; D020521:Stroke / Q000150:complications / Q000473:pathology* / Q000523:psychology*
keywords: Alzheimer's disease; apraxia; function knowledge; left brain damage; manipulation knowledge; tool use