title: Antenna Biphenols: Development of Extended Wavelength Chiroptical Reporters.
abstract: Molecular hosts capable of chiroptical sensing of complexed guest molecules offer an attractive alternative to conventional methods for the analysis of the absolute configuration and enantiopurity. Sensors based on the Pfeiffer effect rely on complexation-driven asymmetric transformation of the first kind and can produce a chiroptical signal against an otherwise null background. To be most effective, the wavelength of the induced chiroptical sensor readout should be free and clear of interfering signals coming from the sample under investigation. In this study, we report the introduction of stereodynamic zinc complexes of antenna biphenols, a new class of sensors bearing antenna-like appendages that can extend the wavelength of the chiroptical signal while also improving enantioselective guest recognition.
authors.affiliation: Department of Chemistry, Georgetown University , Washington, D.C. 20057, United States.
authors.forename: Keith W
authors.initials: KW
authors.lastname: Bentley
authors.affiliation: Department of Process and Analytical Chemistry, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
authors.forename: Leo A
authors.initials: LA
authors.lastname: Joyce
authors.affiliation: Department of Process and Analytical Chemistry, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
authors.forename: Edward C
authors.initials: EC
authors.lastname: Sherer
authors.affiliation: Department of Process and Analytical Chemistry, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
authors.forename: Huaming
authors.initials: H
authors.lastname: Sheng
authors.affiliation: Department of Chemistry, Georgetown University , Washington, D.C. 20057, United States.
authors.forename: Christian
authors.initials: C
authors.lastname: Wolf
authors.affiliation: Department of Process and Analytical Chemistry, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Welch