title: Highly Fluorescent and Photostable Polymeric Nanofibers as Scaffolds for Cell Interfacing and Long-Term Tracking.
abstract: Highly fluorescent polymeric nanofibers fabricated via electrospinning of PCL-DPP-PCL (photostable polycaprolactones-di(thiophene-2-yl)-diketopyrrolopyrrole-photostable polycaprolactones) and commercial PCL mixture show superior photostability and cytocompatibility for long-term tracking of cell-substrate interaction. As a proof of concept, these PCL-DPP-PCL nanofibers enable clear visualization of intricate cell-substrate interactions such as oligodendrocyte myelination.
authors.affiliation: School of Chemical & Biomedical Engineering, Nanyang Technological University, Singapore, 637459.
authors.forename: Hua Jia
authors.initials: HJ
authors.lastname: Diao
authors.affiliation: School of Chemical & Biomedical Engineering, Nanyang Technological University, Singapore, 637459.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: School of Chemical & Biomedical Engineering, Nanyang Technological University, Singapore, 637459.
authors.forename: Hong Yan
authors.initials: HY
authors.lastname: Long
authors.affiliation: School of Chemical & Biomedical Engineering, Nanyang Technological University, Singapore, 637459.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Chemical & Biomedical Engineering, Nanyang Technological University, Singapore, 637459.|Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 636921.
authors.forename: Sing Yan
authors.initials: SY
authors.lastname: Chew
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D058948:Cell Tracking / Q000379:methods*; D005347:Fibroblasts / Q000378:metabolism; D005453:Fluorescence; D006801:Humans; D008027:Light; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D009836:Oligodendroglia / Q000166:cytology; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D011108:Polymers
keywords: electrospinning; fluorescence; myelination; oligodendrocytes; polycaprolactone