title: Volasertib Versus Chemotherapy in Platinum-Resistant or -Refractory Ovarian Cancer: A Randomized Phase II Groupe des Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire Study.
abstract: OBJECTIVE
  Volasertib is a potent and selective cell-cycle kinase inhibitor that induces mitotic arrest and apoptosis by targeting Polo-like kinase. This phase II trial evaluated volasertib or single-agent chemotherapy in patients with platinum-resistant or -refractory ovarian cancer who experienced failure after treatment with two or three therapy lines.
  
  
  METHODS
  Patients were randomly assigned to receive either volasertib 300 mg by intravenous infusion every 3 weeks or an investigator's choice of single-agent, nonplatinum, cytotoxic chemotherapy. The primary end point was 24-week disease control rate. Secondary end points included best overall response, progression-free survival (PFS), safety, quality of life, and exploratory biomarker analyses.
  
  
  RESULTS
  Of the 109 patients receiving treatment, 54 received volasertib and 55 received chemotherapy; demographics were well balanced. The 24-week disease control rates for volasertib and chemotherapy were 30.6% (95% CI, 18.0% to 43.2%) and 43.1% (95% CI, 29.6% to 56.7%), respectively, with partial responses in seven (13.0%) and eight (14.5%) patients, respectively. Median PFS was 13.1 weeks and 20.6 weeks for volasertib and chemotherapy (hazard ratio, 1.01; 95% CI, 0.66 to 1.53). Six patients (11%) receiving volasertib achieved PFS fore more than 1 year, whereas no patient receiving chemotherapy achieved PFS greater than 1 year. No relationship between the expression of the biomarkers tested and their response was determined. Patients treated with volasertib experienced more grade 3 and 4 drug-related hematologic adverse events (AEs) and fewer nonhematologic AEs than did patients receiving chemotherapy. Discontinuation resulting from AEs occurred in seven (13.0%) and 15 (27.3%) patients in the volasertib and chemotherapy arms, respectively. Both arms showed similar effects on quality of life.
  
  
  CONCLUSIONS
  Single-agent volasertib showed antitumor activity in patients with ovarian cancer. AEs in patients receiving volasertib were mainly hematologic and manageable.
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany. epujade@arcagy.org.
authors.forename: Eric
authors.initials: E
authors.lastname: Pujade-Lauraine
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Selle
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Weber
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Isabelle-Laure
authors.initials: IL
authors.lastname: Ray-Coquard
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Ignace
authors.initials: I
authors.lastname: Vergote
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Jozef
authors.initials: J
authors.lastname: Sufliarsky
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Del Campo
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Alain
authors.initials: A
authors.lastname: Lortholary
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Lesoin
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Philippe
authors.initials: P
authors.lastname: Follana
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Gilles
authors.initials: G
authors.lastname: Freyer
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Pardo
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Vidal
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Bengt
authors.initials: B
authors.lastname: Tholander
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Laurence
authors.initials: L
authors.lastname: Gladieff
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Mouna
authors.initials: M
authors.lastname: Sassi
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Pilar
authors.initials: P
authors.lastname: Garin-Chesa
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Serge
authors.initials: S
authors.lastname: Nazabadioko
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Kristell
authors.initials: K
authors.lastname: Marzin
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Korinna
authors.initials: K
authors.lastname: Pilz
authors.affiliation: Eric Pujade-Lauraine, Centre des Cancers de la Femme et Recherche Clinique, Paris; Frédéric Selle, Hôpitaux Universitaires de l'Est Parisien-site Tenon and Alliance Pour la Recherche En Cancérologie, Paris; Béatrice Weber, Centre Alexis Vautrin, Vandoeuvre-les-Nancy; Isabelle-Laure Ray-Coquard, Centre Léon Bérard and Université Claude Bernard-Lyon I, Lyon; Alain Lortholary, Centre Catherine de Sienne, Nantes; Anne Lesoin, Centre Oscar Lambret, Lille; Philippe Follana, Centre Antoine-Lacassagne, Nice; Gilles Freyer, Lyon University, Hospices Civils de Lyon, Pierre-Bénite Cédex; Laurence Gladieff, Institut Claudius Regaud-IUCTO, Toulouse; Mouna Sassi and Serge Nazabadioko, Boehringer Ingelheim, Reims; Florence Joly, Centre François Baclesse, Caen, France; Ignace Vergote, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovakia; Josep Maria Del Campo, Hospital University, Vall d'Hebrón; Beatriz Pardo, Institut Català d'Oncologia-Instituto de Investigación Biomédica de Bellvitge; Laura Vidal, Hospital Clínic de Barcelona, Barcelona, Spain; Bengt Tholander, Uppsala University Hospital, Uppsala, Sweden; Pilar Garin-Chesa, Boehringer Ingelheim, Vienna, Austria; Kristell Marzin, Boehringer Ingelheim, Biberach; and Korinna Pilz, Boehringer Ingelheim, Ingelheim, Germany.
authors.forename: Florence
authors.initials: F
authors.lastname: Joly
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D016190:Carboplatin / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011621:Pteridines / Q000008:administration & dosage / Q000627:therapeutic use*; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; C541363:BI 6727; D014408:Biomarkers, Tumor; D011621:Pteridines; D016190:Carboplatin; D002945:Cisplatin