title: Polysaccharide-based micro/nanocarriers for oral colon-targeted drug delivery.
abstract: Oral colon-targeted drug delivery has attracted many researchers because of its distinct advantages of increasing the bioavailability of the drug at the target site and reducing the side effects. Polysaccharides that are precisely activated by the physiological environment of the colon hold greater promise for colon targeting. Considerable research efforts have been directed towards developing polysaccharide-based micro/nanocarriers. Types of polysaccharides for colon targeting and in vitro/in vivo assessments of polysaccharide-based carriers for oral colon-targeted drug delivery are summarised. Polysaccharide-based microspheres have gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon (colon cancer, inflammatory bowel disease (IBD), amoebiasis and irritable bowel syndrome (IBS)), but also for it's potential for the delivery of anti-rheumatoid arthritis and anti-chronic stable angina drugs. Besides, Polysaccharide-based micro/nanocarriers such as microbeads, microcapsules, microparticles, nanoparticles, nanogels and nanospheres are also introduced in this review.
authors.affiliation: a Shandong Academy of Pharmaceutical Sciences , Jinan , PR China ;
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: b Weihai Institute for Drug Control , Weihai , PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Sang
authors.affiliation: a Shandong Academy of Pharmaceutical Sciences , Jinan , PR China ;
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: a Shandong Academy of Pharmaceutical Sciences , Jinan , PR China ;
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Li
authors.affiliation: a Shandong Academy of Pharmaceutical Sciences , Jinan , PR China ;
authors.forename: Aili
authors.initials: A
authors.lastname: Zhao
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002214:Capsules; D003106:Colon / Q000276:immunology / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism*; D008863:Microspheres; D053758:Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011134:Polysaccharides / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D002214:Capsules; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011134:Polysaccharides
keywords: Micro/nanocarriers; oral colon-targeted drug delivery; polysaccharides