title: Cybernetics, Redux: An Outside-In Strategy for Unraveling Cellular Function.
abstract: A new paper in Science reveals how repetitive stimulation can identify and help to repair fragilities within a signaling network, while using linear mathematical models inspired by engineering, thereby suggesting how cybernetic methods can be integrated into systems and synthetic biology.
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Mohan
authors.initials: M
authors.lastname: Malleshaiah
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jeremy_gunawardena@hms.harvard.edu.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Gunawardena
mesh_terms: D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009997:Osmotic Pressure; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D020928:Mitogen-Activated Protein Kinases