title: Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway.
abstract: Isoliquiritigenin (isoLQ), a chalcone found in licorice, has shown a variety of biological activity including anti-inflammatory and antioxidative effects, and the distribution of isoLQ in gastrointestinal tract was higher than any other tissues. Thus, we evaluated whether or not isoLQ attenuated the dextran sulfate sodium (DSS)-induced colitis by observing the physiological changes (body weight loss, diarrhea, bleeding stool, overall disease activity index (DAI) scores, colon length), histopathological analysis and myeloperoxidase (MPO) activities of esophagus and colon. Also, the MAPK pathways including phosphorylation of ERK1/2, p38, and AKT, and the activation of NK-κB were evaluated in colon tissue. Interestingly, the reduction of body weight and colon length, increase of diarrhea, bloody stool, DAI scores and MPO activity, and histologic disturbances in DSS-induced colitis were recovered by isoLQ treatment. Also, isoLQ treatment suppressed the phosphorylation of ERK1/2 and p38, and the activation of NK-κB compared to those in DSS-induced colitis mice. In addition, the distributions of isoLQ in colon were relatively higher in DSS-induced colitis models. All of these results suggested that isoLQ has potential activity to ameliorate the DSS-induced colitis through the inhibition of MAPK pathway.
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Choi
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
authors.forename: Jin-Kyung
authors.initials: JK
authors.lastname: Bae
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
authors.forename: Hee-Sung
authors.initials: HS
authors.lastname: Chae
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
authors.forename: Young Ok
authors.initials: YO
authors.lastname: Choi
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
authors.forename: Piseth
authors.initials: P
authors.lastname: Nhoek
authors.affiliation: Bio-MAX/N-Bio, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Jong-Sun
authors.initials: JS
authors.lastname: Choi
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea. Electronic address: f2744@dongguk.edu.
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D047188:Chalcones / Q000008:administration & dosage* / Q000627:therapeutic use; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy*; D003106:Colon / Q000187:drug effects* / Q000502:physiology; D016264:Dextran Sulfate; D018450:Disease Progression; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006035:Glycyrrhiza / Q000276:immunology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D016328:NF-kappa B / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D047188:Chalcones; D016328:NF-kappa B; D016264:Dextran Sulfate; C040920:isoliquiritigenin; D009195:Peroxidase; D048049:Extracellular Signal-Regulated MAP Kinases
keywords: Colon; Inflammatory bowel disease; Isoliquiritigenin; MAPK inhibition