title: The Rapid Induction of Carbapenem-Resistance in an Aeromonas dhakensis Blood Isolate.
abstract: Meropenem-susceptible and -resistant Aeromonas dhakensis isolates from blood cultures of a fatal case of septicemia were analyzed. The two isolates were homologous and gene expression of metallo-β-lactamase in the resistant strain was upregulated. Physicians should be aware of the possibility of the induction of carbapenem-resistance, following the use of carbapenems in the treatment of Aeromonas infection.
authors.affiliation: Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences.
authors.forename: Mika
authors.initials: M
authors.lastname: Murata
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Morinaga
authors.forename: Norihiko
authors.initials: N
authors.lastname: Akamatsu
authors.forename: Junichi
authors.initials: J
authors.lastname: Matsuda
authors.forename: Naoki
authors.initials: N
authors.lastname: Uno
authors.forename: Kosuke
authors.initials: K
authors.lastname: Kosai
authors.forename: Hiroo
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Masahiko
authors.initials: M
authors.lastname: Okada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Moriuchi
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
mesh_terms: D000293:Adolescent; D000333:Aeromonas / Q000187:drug effects* / Q000302:isolation & purification; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology*; D001769:Blood / Q000382:microbiology*; D005260:Female; D020869:Gene Expression Profiling; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology*; D006801:Humans; D008297:Male; D000077731:Meropenem; D008875:Middle Aged; D013845:Thienamycins / Q000494:pharmacology*; D013997:Time Factors; D015854:Up-Regulation; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D001618:beta-Lactamases; D000077731:Meropenem