title: A commentary on the 2015 Canadian Clinical Practice Guidelines in glutamine supplementation to parenteral nutrition.
abstract: Glutamine is one of the conditionally essential free amino acids with multiple biological functions. Its supplementation to parenteral nutrition has been widely used for the management of complications in intensive care. However, controversial clinical reports have generated reluctance in the use of this pharmaco-nutrient. In this commentary, we address the impact of four studies that influenced the recommendations on glutamine supplementation by the Canadian Clinical Practice Guide 2015. Because of the importance of this guideline in clinical practice, we strongly believe that a more rigorous and critical evaluation is required to support recommendations in future guidelines.
authors.affiliation: Hematology and Oncology, Department of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, Portugal 61, Second Floor, Santiago, 8330034, Chile. aaleguin@uc.cl.
authors.forename: Alberto
authors.initials: A
authors.lastname: Leguina-Ruzzi
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D016638:Critical Illness / Q000628:therapy*; D004750:Enteral Nutrition; D005260:Female; D005973:Glutamine / Q000008:administration & dosage*; D006706:Homeostasis; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000150:complications* / Q000188:drug therapy*; D009104:Multiple Trauma / Q000628:therapy*; D010288:Parenteral Nutrition; D018805:Sepsis / Q000150:complications*; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D005973:Glutamine