title: Maternal Consumption of Seafood in Pregnancy and Child Neuropsychological Development: A Longitudinal Study Based on a Population With High Consumption Levels.
abstract: Seafood consumption during pregnancy is thought to be beneficial for child neuropsychological development, but to our knowledge no large cohort studies with high fatty fish consumption have analyzed the association by seafood subtype. We evaluated 1,892 and 1,589 mother-child pairs at the ages of 14 months and 5 years, respectively, in a population-based Spanish birth cohort established during 2004-2008. Bayley and McCarthy scales and the Childhood Asperger Syndrome Test were used to assess neuropsychological development. Results from multivariate linear regression models were adjusted for sociodemographic characteristics and further adjusted for umbilical cord blood mercury or long-chain polyunsaturated fatty acid concentrations. Overall, consumption of seafood above the recommended limit of 340 g/week was associated with 10-g/week increments in neuropsychological scores. By subtype, in addition to lean fish, consumption of large fatty fish showed a positive association; offspring of persons within the highest quantile (>238 g/week) had an adjusted increase of 2.29 points in McCarthy general cognitive score (95% confidence interval: 0.42, 4.16). Similar findings were observed for the Childhood Asperger Syndrome Test. Beta coefficients diminished 15%-30% after adjustment for mercury or long-chain polyunsaturated fatty acid concentrations. Consumption of large fatty fish during pregnancy presents moderate child neuropsychological benefits, including improvements in cognitive functioning and some protection from autism-spectrum traits.
authors.forename: Jordi
authors.initials: J
authors.lastname: Julvez
authors.forename: Michelle
authors.initials: M
authors.lastname: Méndez
authors.forename: Silvia
authors.initials: S
authors.lastname: Fernandez-Barres
authors.forename: Dora
authors.initials: D
authors.lastname: Romaguera
authors.forename: Jesus
authors.initials: J
authors.lastname: Vioque
authors.forename: Sabrina
authors.initials: S
authors.lastname: Llop
authors.forename: Jesus
authors.initials: J
authors.lastname: Ibarluzea
authors.forename: Monica
authors.initials: M
authors.lastname: Guxens
authors.forename: Claudia
authors.initials: C
authors.lastname: Avella-Garcia
authors.forename: Adonina
authors.initials: A
authors.lastname: Tardón
authors.forename: Isolina
authors.initials: I
authors.lastname: Riaño
authors.forename: Ainara
authors.initials: A
authors.lastname: Andiarena
authors.forename: Oliver
authors.initials: O
authors.lastname: Robinson
authors.forename: Victoria
authors.initials: V
authors.lastname: Arija
authors.forename: Mikel
authors.initials: M
authors.lastname: Esnaola
authors.forename: Ferran
authors.initials: F
authors.lastname: Ballester
authors.forename: Jordi
authors.initials: J
authors.lastname: Sunyer
mesh_terms: D000328:Adult; D002657:Child Development; D002675:Child, Preschool; D003071:Cognition; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D008628:Mercury / Q000097:blood; D065886:Neurodevelopmental Disorders / Q000453:epidemiology* / Q000517:prevention & control; D009483:Neuropsychological Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D039401:Prenatal Nutritional Physiological Phenomena; D017747:Seafood / Q000706:statistics & numerical data*; D013030:Spain / Q000453:epidemiology
chemical_list: D005231:Fatty Acids, Unsaturated; D008628:Mercury
keywords: autistic spectrum; fatty acids; mercury; neuropsychological development; population-based birth cohorts; pregnancy; seafood intake