title: Health-Related Quality of Life and Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus.
abstract: OBJECTIVE
  The burdens imposed on a child and his/her parents by a diagnosis of type 1 diabetes mellitus (T1DM) adversely affect their health-related quality of life (HRQoL). HRQoL is important for prognosis and is related to metabolic control. To evaluate the HRQoL of Turkish children and adolescents with T1DM and to assess the correlation of HRQoL subscales (including physical and psychosocial health) with metabolic control, and particularly with hypo- and hyperglycaemic episodes.
  
  
  METHODS
  This cross-sectional study included 70 participants with T1DM aged between 8 and 18 years (study group) and 72 healthy controls who were matched to the study group in terms of age, gender, and sociodemographic characteristics (control group), and their parents. HRQoL was determined by the Pediatric Quality of Life Inventory. As an indicator of metabolic control, the most recent hemoglobin A1c (HbA1c) levels were obtained and the number of hypo- and hyperglycaemic episodes over the past one month were checked.
  
  
  RESULTS
  The study group had similar HRQoL scores for children's self-reports and parents' proxy-reports to the control group apart from a decreasing psychosocial health score for parents' proxy-reports in the study group. Although HbA1c level was not related to HRQoL scores, lower number of hypo- and hyperglycaemic episodes were associated with an increase in psychosocial health scores and physical health scores as well as an increase in the total score for parents' proxy-reports.
  
  
  CONCLUSIONS
  Although there was no correlation between metabolic control and HRQoL in children's self-reports, the improving HRQoL levels in parents' proxy-reports were associated with good metabolic control.
authors.affiliation: Erciyes University Faculty of Health Science, Department of Nutrition and Dietetics, Kayseri, Turkey, E-mail: zeynepcaferoglu@gmail.com, zcaferoglu@erciyes.edu.tr.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Caferoğlu
authors.forename: Neriman
authors.initials: N
authors.lastname: İnanç
authors.forename: Nihal
authors.initials: N
authors.lastname: Hatipoğlu
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoğlu
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology*; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human