title: The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice.
abstract: The crude polysaccharide was obtained from the root of Angelica sinensis (AS) to investigate its effect on tumor growth and iron metabolism in H22-bearing mice. In our study, we showed that Angelica sinensis polysaccharide (ASP) was mainly composed of arabinose, glucose and galactose in a molar ratio of 1:1:1.75, with a molecular weight of 80,900 Da and a sugar content of 88.0%. Animal experimental results revealed that three doses of ASP all had anti-tumor effects with inhibition ratios of 27.11%, 31.65% and 37.05%. With respect to iron metabolism, the mean levels of serum hepcidin, interleukin-6 (IL-6), ferritin, transferrin (Tf), transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2) in H22-bearing mice were promoted, and serum iron concentration decreased significantly. After treatment with ASP, these iron-related indicators recovered in different degrees. The findings suggested that the anti-tumor activity of ASP may be affected by its regulation on iron metabolism in H22-bearing mice.
authors.affiliation: Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Road, 430022 Wuhan, China. wkpzhangyu@163.com.
authors.forename: Yao
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Road, 430022 Wuhan, China. wkpzhangyu@163.com.
authors.forename: Jiali
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Road, 430022 Wuhan, China. wkpzhangyu@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China. wkpzcq@126.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China. wkpzcq@126.com.
authors.forename: Kaiping
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Road, 430022 Wuhan, China. wkpzhangyu@163.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001089:Arabinose / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D004195:Disease Models, Animal; D005293:Ferritins / Q000097:blood; D005690:Galactose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D064451:Hepcidins / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000097:blood*; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D009368:Neoplasm Transplantation; D018517:Plant Roots / Q000737:chemistry*; D011134:Polysaccharides / Q000494:pharmacology*; D011990:Receptors, Transferrin / Q000097:blood; D014168:Transferrin / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D064451:Hepcidins; D015850:Interleukin-6; D011134:Polysaccharides; D011990:Receptors, Transferrin; C503641:TFR2 protein, mouse; C480029:Tfrc protein, mouse; D014168:Transferrin; D005293:Ferritins; D001089:Arabinose; D007501:Iron; D005947:Glucose; D005690:Galactose