title: Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity.
abstract: PNAs are emerging as useful synthetic devices targeting natural miRNAs. In particular 3 classes of structurally modified PNAs analogs are herein described, namely α, β and γ, which differ by their backbone modification. Their mode and binding affinity for natural nucleic acids and their use in medicinal chemistry as potential miRNA binders is discussed.
authors.affiliation: a Consiglio Nazionale delle Ricerche-Institute of Cristallography ; Bari , Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Moccia
authors.affiliation: b Centre for Synthesis and Chemical Biology (CSCB); Department of Pharmaceutical & Medicinal Chemistry; Royal College of Surgeons in Ireland ; Dublin , Ireland.
authors.forename: Mauro F A
authors.initials: MF
authors.lastname: Adamo
authors.affiliation: a Consiglio Nazionale delle Ricerche-Institute of Cristallography ; Bari , Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Saviano
mesh_terms: D035683:MicroRNAs / Q000737:chemistry*; D020320:Oligoribonucleotides, Antisense / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*
chemical_list: D035683:MicroRNAs; D020320:Oligoribonucleotides, Antisense; D020135:Peptide Nucleic Acids
keywords: PNA; antisense; backbone modification; chirality; miRNA