title: Surgical treatment of Peyronie's disease with autologous tunica vaginalis of testis.
abstract: BACKGROUND
  To investigate the feasibility and safety of surgical treatment for Peyronie's disease (PD) by excising and repairing plaque using autologous tunica vaginalis of testis.
  
  
  METHODS
  From March 2007 to December 2012, total 19 patients with PD underwent surgical treatment at our center. All patients had significant phallocampsis during erection. All patients complained of decreased sexual function. During the operation, the fibrotic plaque was excised and neurovascular bundle (NVB) was spared. A size-matching autologous tunica vaginalis of testis was harvested as the graft and patched to the defect. All patients received follow up every 3 months in the first year and 6 months in the following years. Data on sexual function before and after the operation was collected and compared.
  
  
  RESULTS
  All operations were completed successfully without serious complications. The mean operative time was 74 min. The mean size of excised plaque was 3.0 cm(2). Postoperative pathological studies revealed the fibroplastic hyperplasia of excised tissue. All patients had satisfactory correction of penile appearance. The erectile penile length between pre- and post-operation didn't show significant difference. Postoperative intercourse satisfaction and overall satisfaction measured by IIEF-5 were significant improved.
  
  
  CONCLUSIONS
  Our surgical treatment is feasible and safe for patients with PD. It can effectively improve the penile cosmetic appearance and patients' intercourse/overall satisfaction on sexual life.
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Bianjiang
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Urology, Suzhou Municipal Hospital, Suzhou, 215000, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Gong
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. nh_song@163.com.
authors.forename: Ninghong
authors.initials: N
authors.lastname: Song
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Min
authors.initials: M
authors.lastname: Gu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Zengjun
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000328:Adult; D007172:Erectile Dysfunction / Q000209:etiology / Q000601:surgery; D005240:Feasibility Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010410:Penile Erection; D010411:Penile Induration / Q000150:complications / Q000601:surgery*; D012189:Retrospective Studies; D012704:Serous Membrane / Q000637:transplantation*; D012735:Sexual Dysfunction, Physiological / Q000209:etiology / Q000601:surgery; D013737:Testis / Q000601:surgery*; D014182:Transplantation, Autologous / Q000379:methods; D016896:Treatment Outcome; D013521:Urologic Surgical Procedures, Male / Q000379:methods*