title: Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders.
abstract: In this study, we found that secreted frizzled-related protein 2 (sFRP2) is overexpressed in the hyperpigmentary skin of melasma and solar lentigo and in acutely UV-irradiated skin. To investigate the effect of sFRP2 on melanogenesis, normal human melanocytes were infected with sFRP2-lentivirus or sh-sFRP2. It was found that sFRP2 stimulates melanogenesis through microphthalmia-associated transcription factor and/or tyrosinase upregulation via β-catenin signaling. The stimulatory action of sFRP2 in pigmentation was further confirmed in melanocytes cocultured with fibroblasts and in ex vivo cultured skin. The findings suggest that sFRP2 functions as a melanogenic stimulator and that it plays a role in the development of UV-induced hyperpigmentary disorders.
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Suwon, Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea; Department of Biomedical Science, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Misun
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Pathology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Han
authors.affiliation: Department of Pathology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Jang-Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea; Department of Biomedical Science, Ajou University School of Medicine, Suwon, Korea; Department of Biochemistry, Ajou University School of Medicine, Suwon, Korea. Electronic address: park64@ajou.ac.kr.
authors.forename: Tae Jun
authors.initials: TJ
authors.lastname: Park
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Suwon, Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea; Department of Biomedical Science, Ajou University School of Medicine, Suwon, Korea. Electronic address: hykang@ajou.ac.kr.
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Kang
mesh_terms: D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology / Q000528:radiation effects; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology / Q000503:physiopathology; D007211:Indoles / Q000378:metabolism* / Q000528:radiation effects; D047908:Intracellular Signaling Peptides and Proteins; D015603:Keratinocytes / Q000378:metabolism / Q000528:radiation effects; D008544:Melanocytes / Q000166:cytology / Q000528:radiation effects; D008565:Membrane Proteins / Q000235:genetics*; D012680:Sensitivity and Specificity; D015398:Signal Transduction; D012867:Skin / Q000166:cytology / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*; D051176:beta Catenin / Q000378:metabolism*; D000099274:Frizzled-Related Proteins; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D006023:Glycoproteins; D007211:Indoles; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051176:beta Catenin; D000099274:Frizzled-Related Proteins; C109618:SFRP2 protein, human; D000094742:Secreted Frizzled-Related Proteins; C009904:melanogen