title: High expression of constitutive photomorphogenic 1 (COP1) is associated with poor prognosis in bladder cancer.
abstract: The present study was to investigate the expression and prognostic value of constitutive photomorphogenic 1 (COP1) in bladder cancer. In our study, real-time quantitative PCR (RT-PCR) was performed to detect 10 pairs of fresh bladder cancer (BCa) and adjacent noncancerous tissues. In addition, immunohistochemistry was utilized to detect the expression of COP1 in 174 clinical bladder cancer samples. What is more, the correlation of COP1 expression and clinicopathological features and clinical outcomes were analyzed. The expression levels of COP1 in clinical bladder cancer were much higher than that in paired adjacent noncancerous tissues (p < 0.0001). High expression of COP1 was closely related with differentiation (p = 0.040) and recurrence (p = 0.001) of patients with bladder cancer. Kaplan-Meier analysis revealed that the expression of COP1 was closely correlated with overall survival (p = 0.048) of bladder cancer, while, recurrence-free survival (p = 0.201). Moreover, Cox multivariate regression analyses showed that COP1 expression was an independent predictor of overall survival (OS; p = 0.027, hazard ratio = 2.127, confidence interval 0.814 to 9.736). Based on our data, the present study suggests that high expression of COP1 may be a novel biological indicator for evaluation of poor prognosis in bladder cancer.
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi Province, People's Republic of China.
authors.forename: Jianlong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi Province, People's Republic of China.
authors.forename: Longwang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi Province, People's Republic of China.
authors.forename: Ruihai
authors.initials: R
authors.lastname: Xiao
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi Province, People's Republic of China.
authors.forename: Qiufeng
authors.initials: Q
authors.lastname: Pan
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi Province, People's Republic of China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi Province, People's Republic of China. kuangrenruiapple@126.com.
authors.forename: Renrui
authors.initials: R
authors.lastname: Kuang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D012044:Regression Analysis; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: C471981:COP1 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: Bladder cancer; COP1 expression; Prognosis