title: [Pharmacokinetics of salvianolic acid A after single intravenous administration in Rhesus monkey].
abstract: Salvianolic acid A (Sal A) is one of the most effective compounds isolated from the root of Salvia miltiorrhiza. Up to now, several studies regarding the pharmacokinetic profiles of Sal A have been reported, however there is no such study reported in monkeys, the species which is more similar to human. The aim of this study is to develop a LC-MS method for the determination of Sal A in monkey plasma and apply it to the pharmacokinetic studies of monkeys. After single intravenous administration of Sal A, the plasma concentration-time curves were observed and the main pharmacokinetic parameters were calculated. The plasma concentration at 2 min (C2 (min)) values were (28.343 ± 6.426), (45.679 ± 12.301) and (113.293 ± 24.360) mg x L(-1) for Rhesus monkeys treated with Sal A at 2.5, 5 and 10 mg x kg(-1). The area under the concentration-time curve (AUC(0-∞)) values were (3.316 ± 0.871), (5.754 ± 2.150) and (13.761 ± 2.825) μg x L(-1) x h, respectively. Furthermore, this method was improved and applied to the simultaneous determination of Sal A, Sal B and Sal C, which provided useful information for preclinical studies and clinical trials of Sal A, Sal B and Sal C.
authors.forename: Jun-ke
authors.initials: JK
authors.lastname: Song
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Wei-ku
authors.initials: WK
authors.lastname: Zhang
authors.forename: Zhang-ying
authors.initials: ZY
authors.lastname: Feng
authors.forename: Tao
authors.initials: T
authors.lastname: Xie
authors.forename: Guan-Hua
authors.initials: GH
authors.lastname: Du
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D002109:Caffeic Acids / Q000493:pharmacokinetics*; D002853:Chromatography, Liquid; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics; D007773:Lactates / Q000493:pharmacokinetics*; D008253:Macaca mulatta; D013058:Mass Spectrometry; D018517:Plant Roots / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry
chemical_list: D002109:Caffeic Acids; D004365:Drugs, Chinese Herbal; D007773:Lactates; C066201:salvianolic acid A