title: Risk Factors for Mechanical Ventilation in Patients with Scrub Typhus Admitted to Intensive Care Unit at a University Hospital.
abstract: BACKGROUND
  The purpose of this study was to evaluate the risk factors for mechanical ventilation in the patients with scrub typhus admitted to intensive care unit (ICU) at a university hospital.
  
  
  METHODS
  We retrospectively selected and analyzed clinical data from the medical records of 70 patients (32 men, 38 women) admitted to the ICU with scrub typhus between 2004 and 2014. The patients had a mean±standard deviation age of 71.2±11.1 years and were evaluated in two groups: those who had been treated with mechanical ventilation (the MV group, n=19) and those who had not (the non-MV group, n=51). Mean ages of the MV group and the non-MV group were 71.2±8.3 years and 71.2±11.1 years, respectively.
  
  
  RESULTS
  Significant differences between the two groups were observed with respect to acute respiratory failure (p=0.008), Acute Physiology and Chronic Health Evaluation (APACHE) II score (p=0.015), Sequential Organ Failure Assessment (SOFA) score (p=0.013), death (p=0.014), and ICU duration (p<0.01). Multivariate analysis indicated that the following factors were significantly associated with mechanical ventilation: acute respiratory failure (p=0.011), SOFA score (p=0.005), APACHE II score (p=0.011), platelet count (p=0.009), and lactate dehydrogenase (LDH) (p=0.011).
  
  
  CONCLUSIONS
  Thus, five factors-acute respiratory failure, SOFA score, APACHE II score, platelet count, and LDH-can be the meaningful indicators for mechanical ventilation for the patients with scrub typhus admitted to ICU.
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Kyoung Min
authors.initials: KM
authors.lastname: Moon
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Min Soo
authors.initials: MS
authors.lastname: Han
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Ch'ang Bum
authors.initials: CB
authors.lastname: Rim
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Min Seok
authors.initials: MS
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Sang Il
authors.initials: SI
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Yongseon
authors.initials: Y
authors.lastname: Cho
keywords: APACHE; Blood Platelets; Intensive Care Units; Lactate Dehydrogenase; Mechanical Ventilations; Scrub Typhus