title: Haemolytic uraemic syndrome with peripheral gangrene and Kawasaki disease in a 15-month-old child.
abstract: A 15-month-old boy presented with atypical haemolytic uraemic syndrome (HUS) (without antecedent diarrhoea or dysentery) following a gluteal abscess and subsequently developed digital gangrene. During plasma infusion therapy for HUS, the clinical features of Kawasaki disease (KD) evolved. Intravenous immunoglobulin and aspirin therapy led to resolution of the KD. The case is notable for development of digital gangrene, a rare phenomenon described with HUS, as well as the development of features of KD. This is the first report of atypical HUS in association with peripheral gangrene and KD. The possible pathophysiological mechanisms are discussed.
authors.affiliation: a Department of Paediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research , Pondicherry , India.
authors.forename: Sriram
authors.initials: S
authors.lastname: Krishnamurthy
authors.affiliation: a Department of Paediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research , Pondicherry , India.
authors.forename: Anbazhagan
authors.initials: A
authors.lastname: Jagadeesh
authors.affiliation: a Department of Paediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research , Pondicherry , India.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Chandrasekaran
authors.affiliation: a Department of Paediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research , Pondicherry , India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Mahadevan
authors.affiliation: b Department of Pathology , Jawaharlal Institute of Postgraduate Medical Education and Research , Pondicherry , India.
authors.forename: Nachiappa Ganesh
authors.initials: NG
authors.lastname: Rajesh
mesh_terms: D000038:Abscess / Q000150:complications / Q000473:pathology; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage; D002081:Buttocks; D005734:Gangrene / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006463:Hemolytic-Uremic Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007155:Immunologic Factors / Q000008:administration & dosage; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D001241:Aspirin
keywords: Digital gangrene; Gluteal abscess; Haemolytic uraemic syndrome; Kawasaki disease