title: Internal exposure levels of typical POPs and their associations with childhood asthma in Shanghai, China.
abstract: Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are common persistent organic pollutants (POPs) that may be associated with childhood asthma. The concentrations of PBDEs, PCBs and OCPs were analyzed in pooled serum samples from both asthmatic and non-asthmatic children. The differences in the internal exposure levels between the case and control groups were tested (p value <0.0012). The associations between the internal exposure concentrations of the POPs and childhood asthma were estimated based on the odds ratios (ORs) calculated using logistic regression models. There were significant differences in three PBDEs, 26 PCBs and seven OCPs between the two groups, with significantly higher levels in the cases. The multiple logistic regression models demonstrated that the internal exposure concentrations of a number of the POPs (23 PCBs, p,p'-DDE and α-HCH) were positively associated with childhood asthma. Some synergistic effects were observed when the children were co-exposed to the chemicals. BDE-209 was positively associated with asthma aggravation. This study indicates the potential relationships between the internal exposure concentrations of particular POPs and the development of childhood asthma.
authors.affiliation: School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China.
authors.forename: Ge
authors.initials: G
authors.lastname: Meng
authors.affiliation: School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.affiliation: School of Environmental Science & Engineering, Shanghai Jiaotong University, Shanghai 200240, PR China.
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: Nie
authors.affiliation: School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Wu
authors.affiliation: School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing 100191, China; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Wu
authors.affiliation: Shanghai Children's Medical Center, Shanghai 200127, PR China. Electronic address: yinyong9999@163.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yin
authors.affiliation: School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital / Faculty of Basic Medicine (or Faculty of Public Health), Shanghai Jiao Tong University School of Medicine; MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: wangyanshjy@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001249:Asthma / Q000139:chemically induced / Q000453:epidemiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004781:Environmental Exposure; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000097:blood*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D015994:Incidence; D008297:Male; D011078:Polychlorinated Biphenyls / Q000097:blood*; D014504:Urban Health
chemical_list: D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D006843:Hydrocarbons, Chlorinated; D011078:Polychlorinated Biphenyls
keywords: Childhood asthma; Internal exposure; Logistic regression model; Persistent organic pollutants; Positive association.