title: Systematic prophylactic oxytocin injection and the incidence of postpartum hemorrhage: A before-and-after study.
abstract: OBJECTIVE
  Assess the impact of routine injection of 5 units of oxytocin as soon as the anterior shoulder is delivered on the incidence of postpartum haemorrhage (PPH) in a context of daily practice.
  
  
  METHODS
  Single-centre before-and-after study evaluating the effect of a change in the protocol for PPH prevention as applied in our obstetrical unit. During the first period, oxytocin (5 units) was to be injected only in case of PPH risk factors. During the second period, the injection was systematic.
  
  
  RESULTS
  In the "before" study period, there were 1953 patients vaginal deliveries and 843 (43%) oxytocin injections, with a protocol compliance of 85%. In the "after" study period, 2018 women had vaginal deliveries and 1911 (95%) had an oxytocin injection (protocol compliance: 95%). The whole study period was associated with a reduced risk of moderate haemorrhage (13.4% vs. 9.2%, P<0.001), but no significant reduced risk of severe haemorrhage was observed (2.1% vs. 2.0%, P=0.79). After logistic regression, the study period remained associated with a significant reduction in the risk of moderate PPH (OR=0.72 [0.58-0.89]).
  
  
  CONCLUSIONS
  Routine injection of 5 units of oxytocin makes it possible to reduce the risk of moderate PPH, but it does not affect the risk of severe PPH.
authors.affiliation: Department of Obstetrics, Jeanne-de-Flandre Hospital, University of Lille North of France, CHRU de Lille, 1, rue Eugène-Avinée, 59037 Lille cedex, France. Electronic address: Charles.garabedian@chru-lille.fr.
authors.forename: C
authors.initials: C
authors.lastname: Garabedian
authors.affiliation: Department of Obstetrics, Jeanne-de-Flandre Hospital, University of Lille North of France, CHRU de Lille, 1, rue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Simon
authors.affiliation: Department of Obstetrics, Jeanne-de-Flandre Hospital, University of Lille North of France, CHRU de Lille, 1, rue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Closset
authors.affiliation: Department of Obstetrics, Jeanne-de-Flandre Hospital, University of Lille North of France, CHRU de Lille, 1, rue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: A-S
authors.initials: AS
authors.lastname: Ducloy-Bouthors
authors.affiliation: Department of Obstetrics, Jeanne-de-Flandre Hospital, University of Lille North of France, CHRU de Lille, 1, rue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Schaffar
authors.affiliation: Department of Obstetrics, Jeanne-de-Flandre Hospital, University of Lille North of France, CHRU de Lille, 1, rue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Deruelle
authors.affiliation: Regional Center of Pharmacovigilance, University of Lille North of France, 59037 Lille cedex , France.
authors.forename: S
authors.initials: S
authors.lastname: Gautier
authors.affiliation: Department of Obstetrics, Jeanne-de-Flandre Hospital, University of Lille North of France, CHRU de Lille, 1, rue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Depret
authors.affiliation: Department of Obstetrics, Jeanne-de-Flandre Hospital, University of Lille North of France, CHRU de Lille, 1, rue Eugène-Avinée, 59037 Lille cedex, France; Inserm, UMR S953, Epidemiological Research Unit on Perinatal Health and Women's Health, Cochin Hospital, 75014 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Subtil
mesh_terms: D000328:Adult; D018890:Chemoprevention / Q000379:methods / Q000592:standards; D036861:Delivery, Obstetric / Q000009:adverse effects* / Q000592:standards / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D007267:Injections; D007749:Labor Stage, Third; D010121:Oxytocin / Q000008:administration & dosage*; D006473:Postpartum Hemorrhage / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data; D011247:Pregnancy; D055815:Young Adult
chemical_list: D010121:Oxytocin
keywords: Accouchement par voie basse; Active management of third stage of labour; Grossesse; Hémorragie du post-partum; Ocytocine; Oxytocin; Postpartum haemorrhage; Pregnancy; Prise en charge active de la troisième phase du travail; Vaginal delivery