title: A new class of Ru(II) polyazine agents with potential for photodynamic therapy.
abstract: Appending anthracene units to [(bpy)2Ru(dpp)](2+) results in Ru(II) agents that exhibit dynamic photoreactivity towards DNA and protein. [(Anthbpy)(bpy)Ru(dpp)](2+) and [(Anthbpy)2Ru(dpp)](2+) are the first metal-organic Ru(II) agent with dpp ligands shown to photomodify DNA in the presence or absence of oxygen, while also binding protein in an oxygen-dependent manner.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA.
authors.forename: Roberto
authors.initials: R
authors.lastname: Padilla
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA.
authors.forename: José A
authors.initials: JA
authors.lastname: Rodriguez-Corrales
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Donohoe
authors.affiliation: Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0406, USA. winkel@vt.edu.
authors.forename: Brenda S J
authors.initials: BS
authors.lastname: Winkel
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Brewer
mesh_terms: D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D017319:Photosensitizing Agents; D017975:Ruthenium Compounds