title: Association between serum levels of high sensitive C-reactive protein and inflammation activity in chronic gastritis patients.
abstract: BACKGROUND
  Gastritis is an important premalignant lesion and recent studies suggested a production of inflammatory cytokine-like C-reactive protein during gastritis. This study aimed to determine any relationship between high sensitive C-reactive protein (hs-CRP) and inflammation activity among patients with gastritis.
  
  
  METHODS
  Demographic and clinical variables of participants were collected by a validated questionnaire. Using histology of the gastric mucosa, Helicobacter pylori status was investigated and serum concentrations of hs-CRP were measured among dyspeptic patients. Correlation between hs-CRP serum levels and inflammation activities was evaluated by logistic regression analysis. The relation between active inflammation and other variables was evaluated by logic link function model.
  
  
  RESULTS
  Totally 239 patients (56.6% female) were analysed. The prevalence of mild, moderate and severe inflammation activities was 66.5%, 23.8% and 9.6% respectively. Mean ± SD of hs-CRP among men and women were 2.85 ± 2.84 mg/dl and 2.80 ± 4.80 mg/dl (p = 0.047) respectively. Mean ± SD of hs-CRP among patients with H. pylori infection, gland atrophy, metaplasia and dysplasia were 2.83 ± 3.80 mg/dl, 3.52 ± 5.1 mg/dl, 2.22 ± 2.3 mg/dl and 5.3 ± 5.04 mg/dl respectively. Relationship between hs-CRP and inflammation activities (p < 0.01) was significant. A significant relationship between dysplasia and hs-CRP (p < 0.04) was revealed. A significant relationship between age and hs-CRP was detected (p < 0.05).
  
  
  CONCLUSIONS
  Although serum hs-CRP is not a specific biomarker for gastritis, elevated hs-CRP levels may be considered as a predictive marker of changes in gastric mucosa and a promising therapeutic target for patients with gastritis.
authors.affiliation: a Student Researches Committee, Ilam University of Medical Sciences , Ilam , Iran ;
authors.forename: Asghar
authors.initials: A
authors.lastname: Rahmani
authors.affiliation: a Student Researches Committee, Ilam University of Medical Sciences , Ilam , Iran ;
authors.forename: Atefeh
authors.initials: A
authors.lastname: Moradkhani
authors.affiliation: b Department of Pathology , Faculty of Medicine, Ilam University of Medical Sciences , Ilam , Iran ;
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Hafezi Ahmadi
authors.affiliation: c Department of Gastroenterology , Faculty of Medicine, Ilam University of Medical Sciences , Ilam , Iran ;
authors.forename: Ali
authors.initials: A
authors.lastname: Jafari Heirdarlo
authors.affiliation: c Department of Gastroenterology , Faculty of Medicine, Ilam University of Medical Sciences , Ilam , Iran ;
authors.forename: Ghobad
authors.initials: G
authors.lastname: Abangah
authors.affiliation: d Department of Epidemiology , Faculty of Medicine, Ilam Medical Sciences University , Ilam , Iran ;|e The Researches Centre of Psychosocial Injuries, Faculty of Medicine, Ilam University of Medical Science , Ilam , Iran ;
authors.forename: Khairollah
authors.initials: K
authors.lastname: Asadollahi
authors.affiliation: e The Researches Centre of Psychosocial Injuries, Faculty of Medicine, Ilam University of Medical Science , Ilam , Iran ;|f Department of Biostatics , Faculty of Medicine, Ilam University of Medical Sciences , Ilam , Iran.
authors.forename: Kourosh
authors.initials: K
authors.lastname: Sayehmiri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000097:blood* / Q000175:diagnosis; D005773:Gastroscopy; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein
keywords: Chronic gastritis; Helicobacter pylori; hs-CRP; inflammation activities