title: Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and it is associated with other medical conditions such as diabetes mellitus, metabolic syndrome, and obesity. The mechanisms of the underlying disease development and progression are not completely established and there is no consensus concerning the pharmacological treatment. In the gold standard treatment for NAFLD weight loss, dietary therapy, and physical activity are included. However, little scientific evidence is available on diet and/or physical activity and NAFLD specifically. Many dietary approaches such as Mediterranean and DASH diet are used for treatment of other cardiometabolic risk factors such as insulin resistance and type-2 diabetes mellitus (T2DM), but on the basis of its components their role in NAFLD has been discussed. In this review, the implications of current dietary and exercise approaches, including Brazilian and other guidelines, are discussed, with a focus on determining the optimal nonpharmacological treatment to prescribe for NAFLD.
authors.affiliation: Department of Gastroenterology, School of Medicine, University of Sao Paulo (USP), 255 Dr. Enéas de Carvalho Aguiar Avenue, Cerqueira César, 05403-900 Sao Paulo, SP, Brazil.
authors.forename: Claudia P
authors.initials: CP
authors.lastname: Oliveira
authors.affiliation: Postgraduate Program in Nutrition, Federal University of Sao Paulo (UNIFESP), 630 Marselhesa Street, Vila Clementino, 04020-060 Sao Paulo, SP, Brazil.
authors.forename: Priscila
authors.initials: P
authors.lastname: de Lima Sanches
authors.affiliation: Division of Interventional Cardiology and Postgraduate Program in Cardiology, Federal University of Sao Paulo (UNIFESP), 715 Napoleao de Barros Street, Vila Clementino, 04024-002 Sao Paulo, SP, Brazil.
authors.forename: Erlon Oliveira
authors.initials: EO
authors.lastname: de Abreu-Silva
authors.affiliation: Department of Nutrition, Federal University of Health Sciences of Porto Alegre (UFCSPA), 245 Sarmento Leite Street, Centro Histórico, 90050-170 Porto Alegre, RS, Brazil; Postgraduate Program in Health Sciences: Cardiology, Institute of Cardiology of Rio Grande do Sul (IC/FUC), 395 Princesa Isabel Avenue, Santana, 90040-371 Porto Alegre, RS, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: Marcadenti
mesh_terms: D004032:Diet; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D065626:Non-alcoholic Fatty Liver Disease / Q000503:physiopathology* / Q000628:therapy*; D009752:Nutritional Status