title: Anti-cancer effects of vitamin C revisited.
abstract: Vitamin C was first suggested to have cancer-fighting properties in the 1930s and has been the subject of controversy ever since. Despite repeated reports of selective cancer cell toxicity induced by high-dose vitamin C treatment in vitro and in mouse models, the mechanism of action has remained elusive.
authors.affiliation: Cancer Metabolism Research Unit, Cancer Research UK, Beatson Institute, Glasgow, UK.
authors.forename: Jiska
authors.initials: J
authors.lastname: van der Reest
authors.affiliation: Cancer Metabolism Research Unit, Cancer Research UK, Beatson Institute, Glasgow, UK.
authors.forename: Eyal
authors.initials: E
authors.lastname: Gottlieb
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D018631:ras Proteins / Q000235:genetics*
chemical_list: D011518:Proto-Oncogene Proteins; D048493:Proto-Oncogene Proteins B-raf; D018631:ras Proteins; D001205:Ascorbic Acid