title: IGF-1 is associated with fetal growth and preterm delivery in type 1 diabetic pregnancy.
abstract: OBJECTIVE
  No data on IGF-1 and either preterm or preeclampsia have been reported so far in diabetic pregnancies. We evaluated consecutive measurements of IGF-1 for preeclampsia, preterm delivery and birth weight in type 1 diabetic pregnancy.
  
  
  METHODS
  In an outpatient university clinic, 97 pregnant women were consecutively recruited for evaluation of indicators for deterioration of diabetes status and adverse perinatal outcome. At every visit, a blood sample for measurement of IGF-1 was drawn.
  
  
  RESULTS
  IGF-1 levels from week 14 to 32 was consistently lower in women who delivered preterm compared with women whose delivered after gestational week 36; the increase in 2nd and 3rd trimester was steeper in those delivering at term than in women delivering preterm (p = 0.032). IGF-1 in preeclampsia did not show the same relation in diabetic women (p = 0.74). The lowest tertile of birth weight ratio (0.8-1.2) was associated with lower IGF-1 from week 14 to 32 (p = 0.047, adjusted for preterm delivery and preeclampsia).
  
  
  CONCLUSIONS
  We found low IGF-1 levels associated with preterm delivery and low birth weight.
authors.affiliation: a Department of Gynecology and Obstetrics , Herning Hospital , Herning , Denmark and.
authors.forename: Finn Friis
authors.initials: FF
authors.lastname: Lauszus
authors.affiliation: b Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Fuglsang
mesh_terms: D000328:Adult; D001724:Birth Weight; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D047109:Fetal Development; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: Birth weight; IGF-1; preeclampsia; preterm delivery; type 1 diabetes mellitus