title: Trichloromethanesulfonyl Chloride: A Chlorinating Reagent for Aldehydes.
abstract: Trichloromethanesulfonyl chloride (CCl3SO2Cl), a commercially available reagent, has been found to perform efficiently in the α-chlorination of aldehydes, including its catalytic asymmetric version, under very mild reaction conditions. Under our reaction conditions, this compound outperforms typical chlorinating reagents for organic synthesis, facilitates workup and purification of the product, and minimizes the formation of toxic, chlorinated organic waste.
authors.affiliation: Department of Biological Chemistry and Molecular Modelling, IQAC-CSIC , c/Jordi Girona 18-24, E08034 Barcelona, Spain.
authors.forename: Ciril
authors.initials: C
authors.lastname: Jimeno
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, CH-3012 Bern, Switzerland.
authors.forename: Lidong
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, CH-3012 Bern, Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Renaud