title: The liver fluke Opisthorchis felineus: biology, epidemiology and carcinogenic potential.
abstract: The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically important liver fluke species belonging to the family Opisthorchiidae and the major agent causing opisthorchiasis over a vast territory, covering Russia, Kazakhstan and several European countries. The similarity between the diseases caused by O. felineus and other liver flukes, O. viverrini and Clonorchis sinensis, in clinical manifestations and course suggests that the scenarios of their development and, possibly, complications have much in common. The International Agency for Research on Cancer classified O. viverrini and C. sinensis as group 1 agents and the major factors inducing cholangiocarcinoma in endemic regions. However, a carcinogenic potential of O. felineus is poorly studied. This review characterizes O. felineus, briefs the epidemiological situation in Western Siberia, the world's largest opisthorchiasis focus, and assesses the carcinogenic potential of this liver fluke. The review is based on a comprehensive analysis of the published medical data on opisthorchiasis and its complications in Western Siberia. Results of performed analysis reflect the actual epidemiological situation in opisthorchiasis focus and suggest an association of this disease with bile duct cancer.
authors.affiliation: Laboratory of Molecular Mechanisms of Pathological Processes, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
authors.forename: Mariya Y
authors.initials: MY
authors.lastname: Pakharukova
authors.affiliation: Laboratory of Molecular Mechanisms of Pathological Processes, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia Laboratory of Pharmacokinetic and Drugs Metabolism, Institute of Molecular Biology and Biophysics Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, 630060, Russia mordvin@bionet.nsc.ru.
authors.forename: Viatcheslav A
authors.initials: VA
authors.lastname: Mordvinov
mesh_terms: D000818:Animals; D001650:Bile Duct Neoplasms / Q000209:etiology* / Q000469:parasitology; D018281:Cholangiocarcinoma / Q000209:etiology* / Q000469:parasitology; D006801:Humans; D008018:Life Cycle Stages; D009889:Opisthorchiasis / Q000150:complications / Q000453:epidemiology / Q000469:parasitology; D009891:Opisthorchis / Q000302:isolation & purification / Q000472:pathogenicity; D015995:Prevalence; D012800:Siberia / Q000453:epidemiology
keywords: Life cycle stages; Liver cancer; Liver fluke; Opisthorchis felineus; Russia