title: Singapore Cancer Network (SCAN) Guidelines for the Systemic Therapy of Endometrial (Uterine) Cancer.
abstract: BACKGROUND
  The SCAN gynaecological cancers systemic therapy workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines for the systemic therapy of endometrial (uterine) cancer.
  
  
  METHODS
  The workgroup utilised a modified ADAPTE process to calibrate high quality international evidence-based clinical practice guidelines to our local setting.
  
  
  RESULTS
  Three international guidelines were evaluated- those developed by the National Cancer Comprehensive Network (2015), the European Society of Medical Oncology (2013) and the Cancer Council Australia (2011). Recommendations on the role of chemotherapy following surgery in women diagnosed with endometrial cancer, the chemotherapeutic options for women with advanced or recurrent endometrial cancers and the role of chemotherapy in women with uterine papillary serous carcinoma or clear cell carcinoma were developed.
  
  
  CONCLUSIONS
  These adapted guidelines form the SCAN Guidelines 2015 for the systemic therapy of endometrial (uterine) cancer.
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D018269:Carcinoma, Endometrioid / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D016889:Endometrial Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D011372:Progestins / Q000008:administration & dosage; D012846:Singapore; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives; D013629:Tamoxifen / Q000008:administration & dosage
chemical_list: D047072:Aromatase Inhibitors; D011372:Progestins; D013629:Tamoxifen; C401859:temsirolimus; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin; D020123:Sirolimus