title: The protective effect of vitamin E against changes in fatty acid composition of phospholipid subclasses in gill tissue of Oreochromis niloticus exposed to deltamethrin.
abstract: The effects of deltamethrin on the fatty acid composition of phospholipid subclasses (phosphatidylchlonine (PC), phosphatidylethanolamine (PE), phosphatidylinositole (PI) and phosphatidylserine (PS)) in gill tissue of Oreochromis niloticus (Perciformes: Cichlidae) and the possible protective effect of vitamin E against deltamethrin were determined by gas chromatography. The changes in the fatty acid profile were analysed after 14 d of exposure. Treatments included Group I (fed with basal diet only), Group II (fed with vitamin E-supplemented diet), Group III (fed with basal diet and exposed to deltamethrin) and Group IV (fed with vitamin E-supplemented diet and exposed to deltamethrin). The effects of deltamethrin on PI, PE and PS were valid for the total saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs). The effect on PC was detected in total SFAs and total PUFAs. The vitamin E-supplemented diet did not show complete protective effect on fatty acid composition of the fish exposed to deltamethrin. However, the protective effect was observed in total SFAs, total MUFAs and total PUFAs in PC. In PI, protective effect was only recorded on total PUFAs. There was no protective effect in PS and PE. The results of the present study demonstrated that deltametrin exposure had harmful effects on cell membrane and treatment with vitamin E could only partially protect fish gills.
authors.affiliation: Dicle University, Faculty Pharmacy, Department of Pharmaceutical Toxicology, TR-21280 Diyarbakir, Turkey. Electronic address: ecengiz@dicle.edu.tr.
authors.forename: Elif Ipek
authors.initials: EI
authors.lastname: Cengiz
authors.affiliation: Dicle University, School of Natural and Applied Sciences, Departmant Biology, TR-21280 Diyarbakir, Turkey.
authors.forename: Ahmet Serhat
authors.initials: AS
authors.lastname: Bayar
authors.affiliation: Dicle University, School of Natural and Applied Sciences, Departmant Biology, TR-21280 Diyarbakir, Turkey.
authors.forename: Veysi
authors.initials: V
authors.lastname: Kizmaz
mesh_terms: D000818:Animals; D023681:Cichlids / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005880:Gills / Q000187:drug effects / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D009570:Nitriles / Q000633:toxicity*; D010743:Phospholipids / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D011722:Pyrethrins / Q000633:toxicity*; D014810:Vitamin E / Q000494:pharmacology*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D005227:Fatty Acids; D007306:Insecticides; D009570:Nitriles; D010743:Phospholipids; D020011:Protective Agents; D011722:Pyrethrins; D014874:Water Pollutants, Chemical; D014810:Vitamin E; C017180:decamethrin
keywords: Deltamethrin; Fatty acid composition; Phospholipid subclasses; Pyrethroid pesticide; Vitamin E