title: Arginine vasopressin (AVP): a review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system.
abstract: BACKGROUND
  This publication reviews the function of arginine vasopressin and focuses on the morphologic and functional correlation between the hormone and its effect on stress, the hypophysial-adrenocortical axis, neuroimmune responses, renal function and corticotroph pituitary tumors.
  
  
  METHODS
  A literature review was performed using various search engines for information regarding the morphology and the multifunctional role of arginine vasopressin.
  
  
  RESULTS
  Although a large number of studies were published discussing these interactions, there are several important areas that are still obscure.
  
  
  CONCLUSIONS
  The questions of how does arginine vasopressin affect the morphology and function of these various areas, and how does the secretion of ACTH and adrenocortical hormones influence the morphology of arginine vasopressin-producing cells and their hormone secretion requires further investigation.
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1T8, Canada. rotondof@smh.ca.
authors.forename: Fabio
authors.initials: F
authors.lastname: Rotondo
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1T8, Canada.
authors.forename: Henriett
authors.initials: H
authors.lastname: Butz
authors.affiliation: Department of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellín, Colombia.
authors.forename: Luis V
authors.initials: LV
authors.lastname: Syro
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1T8, Canada.
authors.forename: George M
authors.initials: GM
authors.lastname: Yousef
authors.affiliation: Department of Neurosurgery, Macquarie University Hospital, Sydney, Australia.
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Ieva
authors.affiliation: Division of Endocrinology, Clinica Medellin, Medellín, Colombia.
authors.forename: Lina M
authors.initials: LM
authors.lastname: Restrepo
authors.affiliation: Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico.
authors.forename: Andres
authors.initials: A
authors.lastname: Quintanar-Stephano
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: Istvan
authors.initials: I
authors.lastname: Berczi
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1T8, Canada.
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma; D000236:Adenoma; D001127:Arginine Vasopressin / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000502:physiology*; D007107:Immune System; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000502:physiology*; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D001127:Arginine Vasopressin
keywords: Arginine vasopressin; Corticotroph cells; Hypothalamus; Pituitary; Receptors