title: Asymmetric synthesis of cyclopentanes bearing four contiguous stereocenters via an NHC-catalyzed Michael/Michael/esterification domino reaction.
abstract: An NHC-catalyzed Michael/Michael/esterification domino reaction via homoenolate/enolate intermediates for the asymmetric synthesis of tetrasubstituted cyclopentanes bearing four contiguous stereocenters is described. A variety of α,β-unsaturated aldehydes and 2-nitroallylic acetates react well with good domino yields and high stereoselectivities.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany. enders@rwth-aachen.de.
authors.forename: Tao
authors.initials: T
authors.lastname: Shu
authors.forename: Qijian
authors.initials: Q
authors.lastname: Ni
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Song
authors.forename: Kun
authors.initials: K
authors.lastname: Zhao
authors.forename: Tianyu
authors.initials: T
authors.lastname: Wu
authors.forename: Rakesh
authors.initials: R
authors.lastname: Puttreddy
authors.forename: Kari
authors.initials: K
authors.lastname: Rissanen
authors.forename: Dieter
authors.initials: D
authors.lastname: Enders