title: Effect of Annexin V on Development of Apoptosis in Placental Syncytiotrophoblast Nuclei during Exacerbation of Cytomegalovirus Infection in the Third Trimester.
abstract: During exacerbation of cytomegalovirus infection during pregnancy, cytomegalovirus proteins penetrate across the external membrane of placental villous syncytiotrophoblast and suppress activities of ATPase and Bcl-2 protein. Simultaneous increase in the content of annexin V and caspase 3 leads to structural disturbances in DNA in syncytiotrophoblast nuclei and stimulates their apoptosis. Structural abnormalities in the syncytiotrophoblast during exacerbation of cytomegalovirus infection are dangerous for fetal development.
authors.affiliation: Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia. lucenkomt@mail.ru.
authors.forename: M T
authors.initials: MT
authors.lastname: Lutsenko
authors.affiliation: Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Andrievskaya
mesh_terms: D017304:Annexin A5 / Q000378:metabolism*; D017209:Apoptosis / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism*; D003586:Cytomegalovirus Infections / Q000378:metabolism; D005260:Female; D006801:Humans; D010920:Placenta / Q000166:cytology* / Q000378:metabolism*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D017304:Annexin A5
keywords: annexin V; apoptosis; placenta