title: Cardiovascular disease-induced thermal responses during passive heat stress: an integrated computational study.
abstract: The cardiovascular system plays a crucial role in human thermoregulation; cardiovascular diseases may lead to significantly degrading the thermoregulation ability for patients during exposure to heat stress. To evaluate the thermal responses of patients with common chronic cardiovascular diseases, we here propose an integrated computational model by coupling a two-node thermoregulation model with a closed-loop, multi-compartment, lumped-parameter cardiovascular model. This bioheat transfer model is validated, capable to predict cardiovascular functions and thermal responses under varying environmental conditions. Our results demonstrate that the cardiovascular disease-induced reduction in cardiac output and skin blood flow causes extra elevation in core temperature during hyperthermic challenges. In addition, a combination of aging, obesity, and cardiovascular diseases shows a pronounced increase in core temperature during heat exposure, which implies that such combined effect may increase the risk of heat-related morbidity and mortality. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Graduate School of Engineering, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba, Japan.|Computational Science Research Program, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
authors.forename: Xiancheng
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Computational Science Research Program, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
authors.forename: Shigeho
authors.initials: S
authors.lastname: Noda
authors.affiliation: Computational Science Research Program, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Himeno
authors.affiliation: Graduate School of Engineering, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba, Japan. hliu@faculty.chiba-u.jp.|Shanghai Jiao Tong University and Chiba University International Cooperative Research Center (SJTU-CU ICRC), 800 Dongchuan Road, Minhang District, Shanghai, China. hliu@faculty.chiba-u.jp.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
mesh_terms: D001833:Body Temperature Regulation / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D003198:Computer Simulation; D006358:Hot Temperature; D006801:Humans; D008954:Models, Biological
keywords: aging; cardiovascular diseases; heat stress; lumped-parameter model; thermoregulation