title: Total Lesion Glycolysis Using ¹⁸F-FDG PET/CT as a Prognostic Factor for Locally Advanced Esophageal Cancer.
abstract: Standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) have been considered prognostic factors for survival in many cancers. However, their prognostic value for radiotherapy-treated squamous esophageal cancer has not been evaluated. In this study, SUV, MTV, and TLG were measured to predict their prognostic role in overall survival (OS) in 38 esophageal cancer patients who had undergone (18)F-FDG PET/CT before radiotherapy. TLG demonstrated higher sensitivity and specificity for predicting OS than MTV and SUV; and a better OS was observed in patients with low TLG compared to those with high TLG in locally advanced disease (OS, 46.9 months; 95% confidence interval [CI], 33.50-60.26 vs. 25.3 months; 95% CI, 8.37-42.28; P=0.003). Multivariate analyses in these patients determined that TLG and the use of combination chemotherapy were the independent prognostic factors for OS (hazard ratio [HR], 7.12; 95% CI, 2.038-24.857; P=0.002 and HR, 6.76; 95% CI, 2.149-21.248; P=0.001, respectively). These results suggest that TLG is an independent prognostic factor for OS and a better predictor of survival than MTV and SUV in patients with locally advanced esophageal cancer treated with radiotherapy.
authors.affiliation: Department of Internal Medicine, Incheon St. Mary's Hospital, Incheon, Korea.
authors.forename: Ji Hyung
authors.identifier: 0000-0002-0492-3959
authors.initials: JH
authors.lastname: Hong
authors.affiliation: Department of Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea.
authors.forename: Hyon Ho
authors.initials: HH
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Daejeon St. Mary's Hospital, Daejeon, Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Han
authors.affiliation: Department of Internal Medicine, Incheon St. Mary's Hospital, Incheon, Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Byun
authors.affiliation: Department of Radiation Oncology, Seoul St. Mary's Hospital, Seoul, Korea.
authors.forename: Hong Seok
authors.initials: HS
authors.lastname: Jang
authors.affiliation: Department of Nuclear Medicine, Incheon St. Mary's Hospital, Incheon, Korea.
authors.forename: Eun Kyoung
authors.initials: EK
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea.
authors.forename: Jin Hyoung
authors.initials: JH
authors.lastname: Kang
authors.affiliation: Department of Nuclear Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ie Ryung
authors.initials: IeR
authors.lastname: Yoo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry; D006019:Glycolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Esophageal Neoplasms, 18F-FDG PET/CT; Metabolic Tumor Volume; Total Lesion Glycolysis