title: Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy.
abstract: A stability-difference-selective bond-breakage strategy for the fabrication of largepore-sized hollow mesoporous organosilica nanoparticles (HMONs) is successfully developed. Moreover, surfacefunctionalized HMONs are successfully constructed to simultaneously deliver P-gp modulator siRNA and anticancer drug doxorubicin to reverse the multidrug resistance of cancer cells.
authors.affiliation: State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, P. R. China.
authors.forename: Meiying
authors.initials: M
authors.lastname: Wu
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, P. R. China.
authors.forename: Qingshuo
authors.initials: Q
authors.lastname: Meng
authors.affiliation: State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, P. R. China.
authors.forename: Lingxia
authors.initials: L
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, P. R. China.
authors.forename: Mengli
authors.initials: M
authors.lastname: Li
authors.affiliation: State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, P. R. China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Cai
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, P. R. China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, P. R. China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Yu
authors.affiliation: State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, P. R. China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, P. R. China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D000497:Alloys / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D002384:Catalysis; D004337:Drug Carriers / Q000737:chemistry*; D018014:Gene Transfer Techniques; D006801:Humans; D008670:Metals / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000497:Alloys; D000970:Antineoplastic Agents; D004337:Drug Carriers; D008670:Metals; D010087:Oxides; D012822:Silicon Dioxide
keywords: cancer therapy; gene delivery; large pores; multidrug resistance; nanoparticles