title: OUTCOME OF DOGS WITH INTRANASAL LYMPHOMA TREATED WITH VARIOUS RADIATION AND CHEMOTHERAPY PROTOCOLS: 24 CASES.
abstract: Tumors of the nasal cavity comprise approximately 1% of all neoplasms in dogs. Canine intranasal lymphoma is rare and reports evaluating the outcome of treatment are lacking. The goal of this observational, descriptive, multi-institutional study was to evaluate the overall median survival times (MSTs) in a group of dogs with intranasal lymphoma that were treated with irradiation and/or chemotherapy. Dogs meeting these inclusion criteria were retrospectively recruited from medical archives at multiple institutions. Eighteen cases of intermediate to high grade intranasal lymphoma and six cases of low-grade intranasal lymphoma were identified. The date of diagnosis, method of diagnosis, treatment received (radiation and/or chemotherapy protocols), and date of death were recorded. Kaplan-Meier survival analysis was performed on the intermediate to high grade group to calculate overall MST. Log-rank tests were performed to compare effects of treatment with radiation therapy ± chemotherapy and chemotherapy alone. Kaplan-Meier survival analysis was performed separately on the low-grade group. The overall MST was 375 days for the intermediate to high grade group. Cases treated with radiation ± chemotherapy had an MST of 455 days (n = 12) and those treated with chemotherapy alone (n = 6) had an MST of 157 days in the intermediate to high grade group. The MST was 823 days for the low-grade group. Results support the use of radiation therapy for treatment of canine intranasal lymphoma, however a randomized, controlled, clinical trial would be needed for more definitive recommendations. The role of adjunctive chemotherapy also may require further investigation.
authors.affiliation: Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn, AL, 36849.
authors.forename: Rebecca
authors.initials: R
authors.lastname: George
authors.affiliation: Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn, AL, 36849.
authors.forename: Annette
authors.initials: A
authors.lastname: Smith
authors.affiliation: Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn, AL, 36849.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Schleis
authors.affiliation: Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn, AL, 36849.
authors.forename: William
authors.initials: W
authors.lastname: Brawner
authors.affiliation: Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn, AL, 36849.
authors.forename: Gregory
authors.initials: G
authors.lastname: Almond
authors.affiliation: Department of Surgical and Radiological Sciences, UC Davis School of Veterinary Medicine, Davis, CA, 95616.
authors.forename: Michael
authors.initials: M
authors.lastname: Kent
authors.affiliation: Department of Clinical Medicine, University of Illinois College of Veterinary Medicine, Urbana-Champaign, IL, 61802.
authors.forename: Jackie
authors.initials: J
authors.lastname: Wypij
authors.affiliation: Instituto Veterinario de Oncología Comparada (IVOC), Valencia, España, and University of Wisconsin-Madison School of Veterinary Medicine, Madison, WI, 53706.
authors.forename: Juan
authors.initials: J
authors.lastname: Borrego
authors.affiliation: Veterinary Oncology Consultants, Wauchope, New South Wales, Australia, 2446.
authors.forename: Antony
authors.initials: A
authors.lastname: Moore
authors.affiliation: Department of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536 and Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, 14853.
authors.forename: Michele
authors.initials: M
authors.lastname: Keyerleber
authors.affiliation: Florida Veterinary Referral Center, Estero, FL, 33928.
authors.forename: Sarah
authors.initials: S
authors.lastname: Kraiza
mesh_terms: D000818:Animals; D024221:Antineoplastic Protocols; D004283:Dog Diseases / Q000188:drug therapy* / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D008223:Lymphoma / Q000188:drug therapy / Q000532:radiotherapy / Q000662:veterinary*; D008297:Male; D009669:Nose Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000662:veterinary*; D012189:Retrospective Studies
keywords: canine; chemotherapy; intranasal; lymphoma; radiation