title: Gonadotropin-Releasing Hormone Analogue Treatment in Females with Moderately Early Puberty: No Effect on Final Height.
abstract: OBJECTIVE
  To investigate the effects of treatment with gonadotropin-releasing hormone analog (GnRHa) on final height in girls who experienced moderately early puberty with symptoms beginning at 7-8.5 years of age.
  
  
  METHODS
  Female cases diagnosed with moderately early puberty which had started between ages 7 to 8.5 years were included in the study. In the treatment groups, all cases with a bone age ≤10.5 years constituted group 1 (n=18) and those with a bone age >10.5 years constituted group 2 (n=23). The 8 patients for which treatment approval could not be obtained constituted group 3. The 49 cases in all three groups were observed until they reached their final height.
  
  
  RESULTS
  Target height, target height standard deviation score (SDS), final height, and final height SDS values were similar in all 3 groups. Final height showed a significant positive correlation with target height (p=0.000, r=0.54) and height at diagnosis (p=0.003, r=0.467) in all groups. Linear regression analysis revealed that a 1 cm longer height at diagnosis increased the final height 0.213 fold, and a 1 cm longer target height at diagnosis increased the final height 0.459 fold.
  
  
  CONCLUSIONS
  We found that GnRHa did not make a positive contribution to final height in cases of moderately early puberty.
authors.affiliation: Ankara University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, Ankara, Turkey Phone: +90 312 305 65 13 E-mail: senaysavas@yahoo.com.
authors.forename: Şenay
authors.initials: Ş
authors.lastname: Savaş-Erdeve
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Şıklar
authors.forename: Bülent
authors.initials: B
authors.lastname: Hacıhamdioğlu
authors.forename: Pınar
authors.initials: P
authors.lastname: Kocaay
authors.forename: Emine
authors.initials: E
authors.lastname: Çamtosun
authors.forename: Gönül
authors.initials: G
authors.lastname: Öcal
authors.forename: Merih
authors.initials: M
authors.lastname: Berberoğlu
mesh_terms: D001827:Body Height / Q000187:drug effects*; D002648:Child; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006130:Growth Disorders / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D011629:Puberty, Precocious / Q000150:complications* / Q000188:drug therapy*
chemical_list: D007987:Gonadotropin-Releasing Hormone; C083781:LHRH, Ala(6)-Gly(10)-ethylamide-