title: Correlations between intratumoral interstitial fibrillary network and vascular network in Srigley patterns of prostate adenocarcinoma.
abstract: OBJECTIVE
  The study aims to assess the both individual behavior and correlations of stromal fibrillary component (SFC) and vascular density (VD) in relation with Srigley architectural patterns of prostate carcinoma.
  
  
  METHODS
  Digital images of prostate adenocarcinoma labeled following both Gleason and Srigley systems were acquired with ×20 objective from two serial sections, 340 from the section stained using Gömöri technique for SFC assessment and another corresponding 340 from the section immunomarked with anti-CD34 antibody for assessment of VD. The SFC amount and VD were determined and compared. Srigley patterns were divided in two redefined behavioral groups: "solid" group (Srigley I, Srigley III, Srigley IV) and "necrotizing" group (Srigley II with subdivisions: Gleason 3A, 3C and 5A).
  
  
  RESULTS
  SFC mean values had an ascending trend in both "solid" and "necrotizing" groups. VD mean values had an ascending trend in "solid" group but a descending trend in "necrotizing" group towards Gleason 5A pattern. SFC and VD values had a direct, ascending correlation for all determinations (p=0.0006), but also for "solid" (p=0.005) and "necrotizing" (p=0.026) groups. The two stromal elements had different behaviors both individually and in their correlation that seem to be related with their interaction with different tumor cellular populations.
  
  
  CONCLUSIONS
  Our results could plead for the hypothesis that the different subtypes of tumor architecture represent steps of a continuous process from well-differentiated status to poorly or undifferentiated status but who is accomplished by two different tumor cells populations with different distinct behavior in their relationship with the stromal microenvironment.
authors.affiliation: Department of Pathology, University of Medicine and Pharmacy of Craiova, Emergency County Hospital of Craiova, Romania; pie1956@yahoo.com.
authors.forename: George
authors.initials: G
authors.lastname: Mitroi
authors.forename: Răzvan Mihail
authors.initials: RM
authors.lastname: Pleşea
authors.forename: Oltin Tiberiu
authors.initials: OT
authors.lastname: Pop
authors.forename: Dragoş Viorel
authors.initials: DV
authors.lastname: Ciovică
authors.forename: Mircea Sebastian
authors.initials: MS
authors.lastname: Şerbănescu
authors.forename: Dragoş Ovidiu
authors.initials: DO
authors.lastname: Alexandru
authors.forename: Adrian
authors.initials: A
authors.lastname: Stoiculescu
authors.forename: Iancu Emil
authors.initials: IE
authors.lastname: Pleşea
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply* / Q000473:pathology*; D006801:Humans; D008297:Male; D010641:Phenotype; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology