title: Short-term results of platelet-rich plasma as adjuvant to 23-G vitrectomy in the treatment of high myopic macular holes.
abstract: OBJECTIVE
  To investigate the short-term safety and efficacy of autologous platelet-rich plasma (a-PRP) as adjuvant to pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling in the treatment of highly myopic macular holes (MH).
  
  
  METHODS
  This was a prospective, nonrandomized interventional case series. Patients with MH associated with high myopia, with or without previous PPV, were included. All patients underwent 23-G PPV with the use of a-PRP. Anatomical and functional results of surgery were recorded.
  
  
  RESULTS
  We included 7 eyes of 6 patients with highly myopic MH. Primary anatomical success was achieved in 7 out of 7 eyes. Mean best-corrected visual acuity improved by more than 1 line from baseline (0.66 ± 0.36 LogMAR) to final visit (0.52 ± 0.25 logMAR), but with no statistically significant difference (p = 0.246, Wilcoxon test). No surgical-related complications were noticed.
  
  
  CONCLUSIONS
  The use of a-PRP as adjuvant to PPV with ILM peeling is effective in the treatment of highly myopic MH. This approach may represent a valid alternative to the inverted ILM flap technique, with comparable visual and anatomical results and the advantage of a simpler procedure. Further studies are necessary to confirm its usefulness in the management of high myopic MH.
authors.affiliation: Vissum Madrid, Madrid - Spain.
authors.forename: Marta S
authors.initials: MS
authors.lastname: Figueroa
authors.affiliation: Vissum Madrid, Madrid - Spain.
authors.forename: Andrea
authors.initials: A
authors.lastname: Govetto
authors.affiliation: Vissum Madrid, Madrid - Spain.
authors.forename: Pablo de
authors.initials: Pd
authors.lastname: Arriba-Palomero
mesh_terms: D000368:Aged; D001485:Basement Membrane / Q000601:surgery; D058450:Endotamponade; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D012167:Retinal Perforations / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D012189:Retrospective Studies; D012827:Silicone Oils / Q000008:administration & dosage; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D005466:Fluorocarbons; D012827:Silicone Oils; C042852:perflutren