title: Alterations in immune function with biologic therapies for autoimmune disease.
abstract: Autoimmune disorders, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, and others, are characterized by dysregulation of various aspects of normal immunity and inflammation. Biologic agents targeting key components of the dysregulated immune response have dramatically improved patient outcomes and transformed treatment paradigms for a number of systemic inflammatory autoimmune diseases. Despite their excellent efficacy, because they do affect normal immune responsiveness, biologic agents can potentially be associated with a variety of adverse effects. Important potential adverse effects related to the use of biologic agents include immunosuppression, which might result in outcomes such as infection, and autoimmunity, that could result in paradoxical inflammation or even autoimmune disease. In this article the current clinical evidence and immunologic mechanisms of the adverse effects related to biologic agents are discussed.
authors.affiliation: Division of Rheumatology, Busan Paik Hospital, Inje University, Busan, South Korea.
authors.forename: Minyoung
authors.initials: M
authors.lastname: Her
authors.affiliation: Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, Calif. Electronic address: akavanaugh@ucsd.edu.
authors.forename: Arthur
authors.initials: A
authors.lastname: Kavanaugh
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology*; D015551:Autoimmunity / Q000187:drug effects; D001691:Biological Therapy / Q000009:adverse effects*; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects
keywords: Biologic agents; adverse effect; autoimmunity; infection; paradoxical inflammation