title: New molecular insights in diabetic nephropathy.
abstract: Diabetes mellitus represents one of the major causes of functional kidney impairment. The review highlights the most significant steps made over the last decades in understanding the molecular basis of diabetic nephropathy (DN), which may provide reliable biomarkers for early diagnosis and prognosis, along with new molecular targets for personalized medicine. There is an increased interest in developing new therapeutic strategies to slow DN progression for improving patients' quality of life and reducing all-cause morbidity and disease-associated mortality. It is highly important to have a science-based medical attitude when facing diabetic patients with associated comorbidities and risk of rapid evolution toward end-stage renal disease. The data discussed herein were mainly from MEDLINE and PubMed articles published in English from 1990 to 2015 and from up-to-date. The search term was "diabetic nephropathy and oxidative stress".
authors.affiliation: Clinical Department No 3, "Carol Davila" University of Medicine and Pharmacy, 37th Dionisie Lupu Street, Sector 1, 020022, Bucharest, Romania.|Department of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital, Bucharest, Romania.|"Victor Babes" National Institute of Pathology, Bucharest, Romania.
authors.forename: Ionel Alexandru
authors.initials: IA
authors.lastname: Checheriţă
authors.affiliation: "Victor Babes" National Institute of Pathology, Bucharest, Romania.
authors.forename: Gina
authors.initials: G
authors.lastname: Manda
authors.affiliation: "Victor Babes" National Institute of Pathology, Bucharest, Romania.|Preclinical Department No 2, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Mihai Eugen
authors.initials: ME
authors.lastname: Hinescu
authors.affiliation: Clinical Department No 3, "Carol Davila" University of Medicine and Pharmacy, 37th Dionisie Lupu Street, Sector 1, 020022, Bucharest, Romania. ileana_peride@yahoo.com.|Department of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital, Bucharest, Romania. ileana_peride@yahoo.com.
authors.forename: Ileana
authors.initials: I
authors.lastname: Peride
authors.affiliation: Clinical Department No 3, "Carol Davila" University of Medicine and Pharmacy, 37th Dionisie Lupu Street, Sector 1, 020022, Bucharest, Romania.|Department of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital, Bucharest, Romania.
authors.forename: Andrei
authors.initials: A
authors.lastname: Niculae
authors.affiliation: Department of Internal Medicine I, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.|Department of Nephrology, "Dr. C. I. Parhon" Clinical Hospital, Iasi, Romania.
authors.forename: Ştefana
authors.initials: Ş
authors.lastname: Bîlha
authors.affiliation: Department of Internal Medicine I, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.|Department of Nephrology, "Dr. C. I. Parhon" Clinical Hospital, Iasi, Romania.
authors.forename: Angelica
authors.initials: A
authors.lastname: Grămăticu
authors.affiliation: Department of Internal Medicine I, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.|Department of Nephrology, "Dr. C. I. Parhon" Clinical Hospital, Iasi, Romania.
authors.forename: Luminiţa
authors.initials: L
authors.lastname: Voroneanu
authors.affiliation: Department of Internal Medicine I, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.|Department of Nephrology, "Dr. C. I. Parhon" Clinical Hospital, Iasi, Romania.
authors.forename: Adrian
authors.initials: A
authors.lastname: Covic
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress; D011379:Prognosis
chemical_list: D015415:Biomarkers
keywords: Diabetic nephropathy; Inflammation; Oxidative stress; Prognosis; Therapy