title: Increased body mass index associated with autonomic dysfunction in Parkinson's disease.
abstract: BACKGROUND
  The association between Parkinson's disease (PD) and body mass index (BMI) has not been established. In this study, we investigated the correlation between BMI and autonomic dysfunction in patients with PD.
  
  
  METHODS
  Clinical features, BMI, cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphy and the coefficient of variation of the electrocardiographic R-R interval (CVRR) were analyzed in 124 patients with PD who were naïve to anti-parkinsonian drugs.
  
  
  RESULTS
  BMI was negatively correlated with early heart-to-mediastinum ratio and CVRR in patients with PD, regardless of disease duration and severity.
  
  
  CONCLUSIONS
  Autonomic dysfunction and BMI increase were associated with each other. Physicians should consider the possibility of autonomic dysfunction in PD patients with high BMI.
authors.affiliation: Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: mochizuki-h@umin.net.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mochizuki
authors.affiliation: Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: akitoshi_taniguchi@med.miyazaki-u.ac.jp.
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Taniguchi
authors.affiliation: Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: yuuki_nakazato@med.miyazaki-u.ac.jp.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakazato
authors.affiliation: Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: nobuyuki_ishii@med.miyazaki-u.ac.jp.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ishii
authors.affiliation: Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: yuka_iwakiri@med.miyazaki-u.ac.jp.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Ebihara
authors.affiliation: Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: t_sugiyama@med.miyazaki-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugiyama
authors.affiliation: Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: shiomik@med.miyazaki-u.ac.jp.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Shiomi
authors.affiliation: Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: nakazato@med.miyazaki-u.ac.jp.
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Nakazato
mesh_terms: D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012189:Retrospective Studies
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine
keywords: Body mass index; Coefficient of variation of the R–R interval; Electrocardiography; MIBG scintigraphy; Parkinson's disease