title: Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage.
abstract: The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is used on a wide variety of terrestrial and aquatic broadleaf weeds. 2,4-D has been shown to produce a wide range of adverse effects on animal and human health. The aim of the current study was to evaluate the effects of pre- and postnatal exposure to 2,4-D on rat ventral prostate (VP). Pregnant rats were exposed daily to oral doses of 70 mg/kg/day of 2,4-D from 16 days of gestation up to 23 days after delivery. Then, the treated groups (n = 8) were fed with a 2,4-D added diet until sacrificed by decapitation on postnatal day (PND) 45, 60, or 90. Morphometric studies were performed and androgen receptor (AR) protein levels in the VP were determined. AR, insulin-like growth factor-I (IGF-1) and insulin-like growth factor-I receptor (IGF-1R) mRNA expression in the VP along with testosterone (T), dihydroxytestosterone (DHT), growth hormone (GH) and IGF-1 serum levels were also determined to ascertain whether these parameters were differentially affected. Results of this study showed that 2,4-D exposure during gestation and until adulthood altered development of the prostate gland in male rats, delaying it at early ages while increasing its size in adults, indicate that 2,4-D could behave as endocrine disruptors (EDs).
authors.affiliation: a Laboratorio De Toxicología Experimental , Facultad De Ciencias Bioquímicas Y Farmacéuticas, Universidad Nacional De Rosario , Rosario , Argentina and.
authors.forename: Arístides A
authors.initials: AA
authors.lastname: Pochettino
authors.affiliation: b Laboratorio De Reproducción Y Lactancia , IMBECU, CONICET, CCT CONICET Mendoza , Mendoza , Argentina.
authors.forename: María Belén
authors.initials: MB
authors.lastname: Hapon
authors.affiliation: a Laboratorio De Toxicología Experimental , Facultad De Ciencias Bioquímicas Y Farmacéuticas, Universidad Nacional De Rosario , Rosario , Argentina and.
authors.forename: Silvana M
authors.initials: SM
authors.lastname: Biolatto
authors.affiliation: a Laboratorio De Toxicología Experimental , Facultad De Ciencias Bioquímicas Y Farmacéuticas, Universidad Nacional De Rosario , Rosario , Argentina and.
authors.forename: María José
authors.initials: MJ
authors.lastname: Madariaga
authors.affiliation: b Laboratorio De Reproducción Y Lactancia , IMBECU, CONICET, CCT CONICET Mendoza , Mendoza , Argentina.
authors.forename: Graciela A
authors.initials: GA
authors.lastname: Jahn
authors.affiliation: a Laboratorio De Toxicología Experimental , Facultad De Ciencias Bioquímicas Y Farmacéuticas, Universidad Nacional De Rosario , Rosario , Argentina and.
authors.forename: Cintia N
authors.initials: CN
authors.lastname: Konjuh
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity*; D005260:Female; D005865:Gestational Age; D013006:Growth Hormone / Q000378:metabolism; D006540:Herbicides / Q000633:toxicity*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D011467:Prostate / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D017208:Rats, Wistar; D011944:Receptors, Androgen / Q000378:metabolism; D012741:Sexual Maturation / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
chemical_list: D052244:Endocrine Disruptors; D006540:Herbicides; D011944:Receptors, Androgen; C548904:insulin-like growth factor-1, rat; D015084:2,4-Dichlorophenoxyacetic Acid; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
keywords: 2,4-Dichlorophenoxyacetic herbicide; androgen receptor; developmental toxicity; hormone