title: Correlation of human papilloma virus with oral squamous cell carcinoma in Chinese population.
abstract: Previous studies indicated that oral squamous cell carcinomas (OSCC) might be related to human papilloma virus (HPV) infection. However, the relationship between OSCC in a Chinese population and oral HPV infection is still unclear. In this study, we evaluate the relationship of OSCC with HPV infection in a Chinese population via a meta-analysis. The reports on HPV and OSCC in a Chinese population published between January, 1994, and October, 2015 were retrieved via CNKI/WANFANG/pubmed databases. According to the inclusion criteria, we selected 26 eligible case-control studies. After testing the heterogeneity of the studies by the Cochran Q test, the meta-analyses for HPV and HPV16 were performed using the random effects model. Quantitative meta-analyses showed that, compared with normal oral mucosa the combined odds ratio of OSCC with HPV infection were 1.98 (95% CI: 1.34-2.92). The test for overall effect showed that the P value was less than 0.05 (Z = 3.46). Forest plot analyses were seen in Figures 2 and 3. Publication bias and bias risk analysis using RevMan 5.3 software were measured indicators of the graphics of the basic symmetry. High incidences of HPV infection were found in the samples of Chinese OSCC. For the Chinese population, HPV infection elevates the risk of OSCC tumorigenesis.
authors.affiliation: Department of Oral Medicine, School of Stomatology, Wannan Medical College Wuhu 241002, China.
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Wannan Medical College Wuhu 241001, China.
authors.forename: Detao
authors.initials: D
authors.lastname: Tao
authors.affiliation: Department of Oral Medicine, School of Stomatology, Wannan Medical College Wuhu 241002, China.
authors.forename: Daofang
authors.initials: D
authors.lastname: Tang
authors.affiliation: Department of Oncology IV, First Hospital of Shijiazhuang Shijiazhuang 050011, China.
authors.forename: Zhenlin
authors.initials: Z
authors.lastname: Gao
keywords: Chinese; Human papilloma virus; oral squamous cell carcinoma