title: Aggregation induced emission from α-napthoflavone microstructures and its cyto-toxicity.
abstract: α-Napthoflavone (ANF) microstructures of various morphologies were synthesized using reprecipitation method. Sodium Dodecyl Sulfate (SDS) was used as morphology directing agent. The morphologies of the particles were characterized using optical and scanning electron microscopy (SEM). Single crystal data of ANF suggests that the aromatic units of ANF are in parallel slipped conformation in its aggregated form. Photophysical properties of aggregated ANF hydrosol were studied using UV-Vis absorption, steady state and time resolved spectroscopy. Red shift and broadening of UV-Vis spectra of ANF hydrosol are explained due to strong π-π and H-π interactions among the neighboring ANF molecules within the aggregated microstructures. Though ANF is non-luminescent in good solvent, a strong emission is observed in its aggregated state. This aggregation induced emission (AIE) has been explained due to restriction of intramoleculer rotation and large amplitude vibrational modes of ANF in its aggregated state. Our Photophysical study also reveals that AIE effect decreases after an optimum concentration of ANF and this has been explained due to softening of crystal lattice. Cytotoxicity of ANF hydrosol was examined to get an idea of the toxic level of this hydrosol toward cultured normal human cells. It is observed that ANF hydrosol may draw beneficial effect in biological application as it has no higher toxic activity but has antioxidant property.
authors.affiliation: Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore 721102, W.B, India.
authors.forename: Debasish
authors.initials: D
authors.lastname: Das
authors.affiliation: Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore 721102, W.B, India.
authors.forename: Prativa
authors.initials: P
authors.lastname: Mazumdar
authors.affiliation: Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore 721102, W.B, India.
authors.forename: Ashim
authors.initials: A
authors.lastname: Maity
authors.affiliation: Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore 721102, W.B, India.
authors.forename: Satyajit
authors.initials: S
authors.lastname: Tripathy
authors.affiliation: Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore 721102, W.B, India.
authors.forename: Somenath
authors.initials: S
authors.lastname: Roy
authors.affiliation: Department of Polymer Science and Technology, University College of Science and Technology, 92 APC Road, Kolkata 700009, West Bengal, India.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Chattopadhyay
authors.affiliation: Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore 721102, W.B, India. Electronic address: ajay@mail.vidyasagar.ac.in.
authors.forename: Ajay
authors.initials: A
authors.lastname: Misra
mesh_terms: D001571:Benzoflavones / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes; D006801:Humans; D015394:Molecular Structure; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001571:Benzoflavones; D005456:Fluorescent Dyes; D012967:Sodium Dodecyl Sulfate; C011512:alpha-naphthoflavone
keywords: Aggregation induce emission (AIE); Cytotoxicity; Fluorescence; Restricted intramolecular rotation (RIR); XRD; α-napthoflavone