title: The real-life value of ST2 monitoring during heart failure decompensation: impact on long-term readmission and mortality.
abstract: BACKGROUND
  Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements.
  
  
  OBJECTIVE
  The objective of this study is to investigate the prognostic value of ST2 in AHF.
  
  
  METHODS
  ST2 levels were determined at admission (n = 182) and discharge (n = 85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year.
  
  
  RESULTS
  Discharge ST2 (HR 2.42 [95% CI 1.46-4], p = 0.001) and ΔST2 (HR 2.32 [95% CI 1.21-4.57], p = 0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP.
  
  
  CONCLUSIONS
  Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information.
authors.affiliation: a Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol , Badalona , Spain .
authors.forename: Cinta
authors.initials: C
authors.lastname: Llibre
authors.affiliation: a Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol , Badalona , Spain .|b Department of Medicine , Autonomous University of Barcelona , Barcelona , Spain , and.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Zamora
authors.affiliation: a Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol , Badalona , Spain .
authors.forename: Àngel
authors.initials: À
authors.lastname: Caballero
authors.affiliation: a Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol , Badalona , Spain .|b Department of Medicine , Autonomous University of Barcelona , Barcelona , Spain , and.
authors.forename: Josep
authors.initials: J
authors.lastname: Lupón
authors.affiliation: a Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol , Badalona , Spain .
authors.forename: Alba
authors.initials: A
authors.lastname: Ros
authors.affiliation: a Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol , Badalona , Spain .
authors.forename: Nuria
authors.initials: N
authors.lastname: Benito
authors.affiliation: a Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol , Badalona , Spain .
authors.forename: Marta
authors.initials: M
authors.lastname: de Antonio
authors.affiliation: c Biochemistry Service, Hospital Universitari Germans Trias I Pujol , Badalona , Spain.
authors.forename: Amparo
authors.initials: A
authors.lastname: Galán
authors.affiliation: a Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol , Badalona , Spain .
authors.forename: Mar
authors.initials: M
authors.lastname: Domingo
authors.affiliation: a Heart Failure Unit and Cardiology Service, Hospital Universitari Germans Trias I Pujol , Badalona , Spain .|b Department of Medicine , Autonomous University of Barcelona , Barcelona , Spain , and.
authors.forename: Antoni
authors.initials: A
authors.lastname: Bayes-Genis
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D006760:Hospitalization; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010351:Patient Discharge; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Acute heart failure; ST2; biomarkers; outcomes; prognosis