title: Clinical evaluation of an antiinflammatory and antioxidant diet effect in 30 dogs affected by chronic otitis externa: preliminary results.
abstract: The aim of this evaluation study was to assess the possible role of a specific nutraceutical diet in relieving main clinical symptoms of chronic bilateral otitis externa (occlusion of ear canal, erythema, discharge quantity, and odor) in 30 adult dogs. Thirty dogs of different breeds (mean age ± SEM; 6.03 ± 0.15 years and mean weight ± SEM; 32.01 ± 1.17 Kg; 53.3% males, 46.6% females) with evident chronic clinical otitis symptoms were equally divided and randomly assigned to receive either the nutraceutical diet (ND group) or a standard diet (SD group) over a period of 90 days. In all cases a topical pharmacological treatment was given. The nutraceutical diet, also endowed with anti-inflammatory and antioxidant activities, significantly decreased the mean score intensity of all symptoms after 90 days of intervention (P < 0.0001) with the exception of Malassezia pachydermatis infection which was only slightly reduced. Our investigation is one of the few evidence-based results where a commercial nutraceutical diet has been proven effective, in combination with drugs, in relieving otitis externa-related symptoms. This study opens new insights into otitis externa clinical management providing evidence of efficacy of a combined therapy with drugs and a specific nutraceutical diet.
authors.affiliation: School of Specialization in Clinical Biochemistry, "G. d'Annunzio" University, Chieti, Italy. alessandro811@hotmail.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Di Cerbo
authors.affiliation: Research and Development Department, SANYpet S.p.a., Bagnoli di Sopra, Padua, Italy. Sarac.sanypet@forza10.com.
authors.forename: Sara
authors.initials: S
authors.lastname: Centenaro
authors.affiliation: School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy. francesca.beribe@unicam.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Beribè
authors.affiliation: School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy. fulvio.laus@unicam.it.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Laus
authors.affiliation: School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy. matteo.cerquetella@unicam.it.
authors.forename: Matteo
authors.initials: M
authors.lastname: Cerquetella
authors.affiliation: School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy. andrea.spaterna@unicam.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Spaterna
authors.affiliation: Research and Development Department, SANYpet S.p.a., Bagnoli di Sopra, Padua, Italy. Gianandrea.sanypet@forza10.com.
authors.forename: Gianandrea
authors.initials: G
authors.lastname: Guidetti
authors.affiliation: Research and Development Department, SANYpet S.p.a., Bagnoli di Sopra, Padua, Italy. Sergio.sanypet@forza10.com.
authors.forename: Sergio
authors.initials: S
authors.lastname: Canello
authors.affiliation: Department of Science, University of Basilicata, Potenza, Italy. giuseppe.terrazzano@unibas.it.|Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy. giuseppe.terrazzano@unibas.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Terrazzano
mesh_terms: D000818:Animals; D004032:Diet / Q000662:veterinary*; D019587:Dietary Supplements; D004283:Dog Diseases / Q000178:diet therapy*; D004285:Dogs; D005260:Female; D008297:Male; D010032:Otitis Externa / Q000178:diet therapy / Q000662:veterinary*; D016896:Treatment Outcome
keywords: Antiinflammatory and antioxidant activities; Nutraceutical diet; Otitis externa; Symptoms intensity decrease