title: New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae).
abstract: Six new 9-hydroxybriarane diterpenoids, briarenolides ZI-ZVI (1-6), were isolated from a gorgonian coral Briareum sp. The structures of briaranes 1-6 were elucidated by spectroscopic methods and by comparison of their spectroscopic data with those of related analogues. Briarenolides ZII (2) and ZVI (6) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
authors.affiliation: Department of Marine Biotechnology &amp; Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. gobetter04@yahoo.com.tw.|National Museum of Marine Biology &amp; Aquarium, Pingtung 944, Taiwan. gobetter04@yahoo.com.tw.
authors.forename: Yin-Di
authors.initials: YD
authors.lastname: Su
authors.affiliation: Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan. sung6119@gmail.com.|School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. sung6119@gmail.com.
authors.forename: Chun-Sung
authors.initials: CS
authors.lastname: Sung
authors.affiliation: Department of Marine Biotechnology &amp; Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.|Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University &amp; Academia Sinica, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.affiliation: National Museum of Marine Biology &amp; Aquarium, Pingtung 944, Taiwan. kb5634@yahoo.com.tw.|Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan. kb5634@yahoo.com.tw.
authors.forename: Yu-Hsin
authors.initials: YH
authors.lastname: Chen
authors.affiliation: National Museum of Marine Biology &amp; Aquarium, Pingtung 944, Taiwan. jay0404@gmail.com.|Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University &amp; Academia Sinica, Kaohsiung 804, Taiwan. jay0404@gmail.com.
authors.forename: Yu-Chia
authors.initials: YC
authors.lastname: Chang
authors.affiliation: Department of Pharmacy &amp; Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. jjchen@tajen.edu.tw.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
authors.affiliation: School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.affiliation: Department of Marine Biotechnology &amp; Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.|Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University &amp; Academia Sinica, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
authors.affiliation: Department of Marine Biotechnology &amp; Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.|National Museum of Marine Biology &amp; Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.|Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008958:Models, Molecular; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D008070:Lipopolysaccharides; D052247:Nitric Oxide Synthase Type II
keywords: Briareum; anti-inflammatory; briarane; briarenolide; gorgonian; iNOS