title: Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology.
abstract: Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic anemia, episodic vaso-occlusion, and progressive organ damage. Current management of the disease remains symptomatic or preventative. Specific treatment targeting major complications such as vaso-occlusion is still lacking. Recent studies have identified various cellular and molecular factors that contribute to the pathophysiology of SCD. Here, we review the role of these elements and discuss the opportunities for therapeutic intervention.
authors.affiliation: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Cell Biology.
authors.forename: Dachuan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Cell Biology.
authors.forename: Chunliang
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Pediatrics, and.
authors.forename: Deepa
authors.initials: D
authors.lastname: Manwani
authors.affiliation: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Cell Biology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Frenette
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood* / Q000473:pathology / Q000628:therapy*; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology / Q000628:therapy; D009504:Neutrophils / Q000378:metabolism* / Q000473:pathology