title: Distinctive sleep problems in children with perinatal moderate or mild hypoxic-ischemia.
abstract: Extensive studies focus on the cognitive and motor impairments after perinatal hypoxic-ischemia (HI). Sleep problems, although reported to be associated with cerebral palsy (CP), are often overlooked in non-severe HI patients. Here, by investigating the sleep qualities of children with different degrees of HI, we discovered that sleep initiation and maintenance, sleep-related breathing problems, or circadian rhythmic issues were highly associated with children of moderate or mild HI, respectively. Follow-up MRI studies in 2-year old patients showed that periventricular white matter lesions including periventricular leukomalacia (PVL) were prevalent in moderate, but not mild, HI children. In contrast, the occurrence of pineal cysts had a high risk in children with mild HI. Our study provides novel insights into the mechanisms of distinctive sleep problems associated with children of different degrees of HI, and therefore sheds light on the studies of targeted therapeutic treatments for sleep disorders in children who suffer from HI.
authors.affiliation: Division of Neonatology, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Neurology, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Division of Neonatology, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.affiliation: Center for Circadian Clocks, Medical College, Soochow University, Suzhou 215003, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Radiology, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Division of Neonatology, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Xing
authors.initials: X
authors.lastname: Han
authors.affiliation: Division of Neonatology, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Rehabilitation, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Rehabilitation, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Xujun
authors.initials: X
authors.lastname: Cao
authors.affiliation: Division of Neonatology, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Po
authors.initials: P
authors.lastname: Miao
authors.affiliation: Division of Neonatology, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Wanliang
authors.initials: W
authors.lastname: Guo
authors.affiliation: Department of Rehabilitation, Children's Hospital of Soochow University, Suzhou 215003, PR China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Gu
authors.affiliation: Division of Neonatology, Children's Hospital of Soochow University, Suzhou 215003, PR China. Electronic address: xing_feng66@suda.edu.cn.
authors.forename: Xing
authors.initials: X
authors.lastname: Feng
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002675:Child, Preschool; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D007969:Leukomalacia, Periventricular / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D012893:Sleep Wake Disorders / Q000473:pathology / Q000503:physiopathology*
keywords: Circadian rhythmic issues; Hypoxic-ischemia (HI); Periventricular leukomalacia (PVL); Pineal cyst; Sleep problems; Sleep–wake cycle