title: Possible Immune Regulation of Natural Killer T Cells in a Murine Model of Metal Ion-Induced Allergic Contact Dermatitis.
abstract: Metal often causes delayed-type hypersensitivity reactions, which are possibly mediated by accumulating T cells in the inflamed skin, called irritant or allergic contact dermatitis. However, accumulating T cells during development of a metal allergy are poorly characterized because a suitable animal model is unavailable. We have previously established novel murine models of metal allergy and found accumulation of both metal-specific T cells and natural killer (NK) T cells in the inflamed skin. In our novel models of metal allergy, skin hypersensitivity responses were induced through repeated sensitizations by administration of metal chloride and lipopolysaccharide into the mouse groin followed by metal chloride challenge in the footpad. These models enabled us to investigate the precise mechanisms of the immune responses of metal allergy in the inflamed skin. In this review, we summarize the immune responses in several murine models of metal allergy and describe which antigen-specific responses occur in the inflamed skin during allergic contact dermatitis in terms of the T cell receptor. In addition, we consider the immune regulation of accumulated NK T cells in metal ion-induced allergic contact dermatitis.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-3-1 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. kumagai-kenichi@tsurumi-u.ac.jp.|Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan. kumagai-kenichi@tsurumi-u.ac.jp.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kumagai
authors.affiliation: Department of Dermatology, Nishi-Kobe Medical Center, 5-7-1 Kojidai, Kobe 651-2273, Japan. thorikaw@med.kobe-u.ac.jp.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Horikawa
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-3-1 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. shigematsu-h@tsurumi-u.ac.jp.|Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan. shigematsu-h@tsurumi-u.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shigematsu
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-3-1 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. matsubara-ryota@tsurumi-u.ac.jp.|Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan. matsubara-ryota@tsurumi-u.ac.jp.
authors.forename: Ryota
authors.initials: R
authors.lastname: Matsubara
authors.affiliation: Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan. k-kitaura@sagamihara-hosp.gr.jp.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kitaura
authors.affiliation: Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan. fhb19830419@yahoo.co.jp.|Department of Oral and Maxillofacial Surgery, Toshiba Rinkan Hospital, 7-9-1 Kamitsuruma, Minami-ku, Sagamihara 252-0385, Japan. fhb19830419@yahoo.co.jp.
authors.forename: Takanori
authors.initials: T
authors.lastname: Eguchi
authors.affiliation: Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan. hirok0614@yahoo.co.jp.|Department of Oral and Maxillofacial Surgery, Shonan Tobu Hospital, 500 Nishikubo, Chigasaki 253-0083, Japan. hirok0614@yahoo.co.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-3-1 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. from7ritoyou@gmail.com.
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Nakasone
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-3-1 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. sato-ki@tsurumi-u.ac.jp.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Sato
authors.affiliation: Division of Oral Maxillofacial Surgery, Department of Reconstructive Oral and Maxillofacial Surgery, Iwate Medical University School of Dentistry, Morioka, Iwate 020-8505, Japan. yamadah@iwate-med.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamada
authors.affiliation: Section of Biological Sciences, Research Center for Odontology, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan. satsukis@tky.ndu.ac.jp.
authors.forename: Satsuki
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-3-1 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. hamada-y@tsurumi-u.ac.jp.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hamada
authors.affiliation: Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan. r-suzuki@sagamihara-hosp.gr.jp.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D017449:Dermatitis, Allergic Contact / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D015870:Gene Expression; D006119:Groin; D006614:Hindlimb; D006801:Humans; D007267:Injections; D008070:Lipopolysaccharides / Q000494:pharmacology; D019216:Metals, Heavy / Q000494:pharmacology*; D051379:Mice; D055611:Natural Killer T-Cells / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology*; D012867:Skin / Q000187:drug effects / Q000276:immunology* / Q000473:pathology
chemical_list: D008070:Lipopolysaccharides; D019216:Metals, Heavy; D011948:Receptors, Antigen, T-Cell
keywords: T cell receptor; delayed-type hypersensitivity; metal allergy; metal ion; natural killer T cells