title: Suppression of host PTEN gene expression for Leishmania donovani survival in Indian visceral leishmaniasis.
abstract: Lipid phosphatase, PTEN is amongst the host gene actively involved in determining disease susceptibility. Expression of pten and other genes in vicinity egr1 &4e-bp1 were evaluated in splenic tissue before and after treatment in visceral leishmaniasis patients. Lower expression of egr1 in correlation with pten suppressed 4e-bp1 gene in active cases. The higher levels of pten mRNA expression post treatment confirmed its role in effective clearance of Leishmania. Therefore, it is hypothesized that lower mRNA expression of pten is due to suppression of egr1 activates PI3K signaling bestowing host the ability to cope up infection and continue its normal metabolic machinery.
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, UP, India.
authors.forename: Medhavi
authors.initials: M
authors.lastname: Sudarshan
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, UP, India.
authors.forename: Toolika
authors.initials: T
authors.lastname: Singh
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, UP, India.
authors.forename: Bhawana
authors.initials: B
authors.lastname: Singh
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, UP, India.
authors.forename: Jaya
authors.initials: J
authors.lastname: Chakravarty
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, UP, India. Electronic address: drshyamsundar@hotmail.com.
authors.forename: Shyam
authors.initials: S
authors.lastname: Sundar
mesh_terms: D015536:Down-Regulation; D015870:Gene Expression; D006801:Humans; D057131:Immune Evasion; D007893:Leishmania donovani / Q000472:pathogenicity*; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000473:pathology*; D051059:PTEN Phosphohydrolase / Q000037:antagonists & inhibitors*
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: 4e-bp1; PI3K signaling; Visceral leishmaniasis; egr1; mRNA expression; pten