title: Do preoperative serum vascular endothelial growth factor and migration-inhibitory factor predict the nature of the adnexal masses? A prospective-controlled trial.
abstract: The aim of this study was to identify the role of preoperative serum vascular endothelial growth factor (VEGF) and migration inhibitor factor (MIF) in differentiation of benign and malignant adnexal masses, as well as the relationship between prognostic factors and VEGF and MIF in ovarian cancer patients. This prospective study included 41 patients who were admitted between November 2010 and March 2012. In the malignant group, there were 21 patients, and remaining 20 had benign adnexal masses. Age, CA125 levels, grade, stage, presence of ascites and the degree of cytoreduction performed were noted. There was no significant difference between two groups in preoperative serum VEGF and MIF levels (p = 0.118 and p = 0.297, respectively). CA125 levels were significantly higher in the malignant group (p < 0.0001). There was no significant difference for VEGF and MIF between the groups evaluated for tumour grade, stage, presence of ascites and degree of cytoreduction performed in the malignant group. Preoperative serum, VEGF and MIF levels are not suitable for the differentiation of malignant and benign adnexal masses, and they do not correlate with the prognostic factors of ovarian cancer in this cohort of patients.
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Ege University , Izmir , Turkey .
authors.forename: Nuri
authors.initials: N
authors.lastname: Yildirim
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Ege University , Izmir , Turkey .
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Dikmen
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Ege University , Izmir , Turkey .
authors.forename: Mustafa Cosan
authors.initials: MC
authors.lastname: Terek
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Ege University , Izmir , Turkey .
authors.forename: Levent
authors.initials: L
authors.lastname: Akman
authors.affiliation: b Department of Medical Biology, Faculty of Medicine , Ege University , Izmir , Turkey , and.
authors.forename: Nur Selvi
authors.initials: NS
authors.lastname: Gunel
authors.affiliation: b Department of Medical Biology, Faculty of Medicine , Ege University , Izmir , Turkey , and.
authors.forename: Cagdas
authors.initials: C
authors.lastname: Aktan
authors.affiliation: c Department of Pathology, Faculty of Medicine , Ege University , Izmir , Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Zekioglu
authors.affiliation: b Department of Medical Biology, Faculty of Medicine , Ege University , Izmir , Turkey , and.
authors.forename: Cumhur
authors.initials: C
authors.lastname: Gunduz
mesh_terms: D000291:Adnexal Diseases / Q000097:blood* / Q000601:surgery; D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood* / Q000601:surgery; D011237:Predictive Value of Tests; D057234:Preoperative Period; D011379:Prognosis; D011446:Prospective Studies; D042442:Vascular Endothelial Growth Factors / Q000097:blood*
chemical_list: D018394:CA-125 Antigen; D008263:Macrophage Migration-Inhibitory Factors; D042442:Vascular Endothelial Growth Factors; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human
keywords: Adnexal mass; migration inhibitory factor; ovarian cancer; vascular endothelial growth factor