title: Down-regulation of C12orf59 is associated with a poor prognosis and VHL mutations in renal cell carcinoma.
abstract: C12orf59 is newly identified gene in kidney. However, the relation of C12orf59 expression and clinic features is unknown. Here, our study showed that C12orf59 was broadly expressed in normal human tissues with high expression levels in kidney while its expression is beyond detectable in a panel of cancer cell lines. C12orf59 expression in RCC was significantly decreased compared with corresponding adjacent noncancerous tissues (P < 0.01). The decreased C12orf59 expression was correlated with lymph node status (P < 0.05), distant metastases (P < 0.05), poor survival (P < 0.001) (HR 3.00; 95% CI, 1.29-7.53), VHL non-sense mutations or frame-shift mutations (P < 0.01), and UMPP gene non-sense mutations or frame-shift mutations (P = 0.01). Thus, we propose that the decreased C12orf59 expression status is a prognostic biomarker of ccRCC and cooperates with the loss of VHL all the while promoting renal carcinogenesis.
authors.affiliation: Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.|Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.affiliation: Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Chuangzhi
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.|Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Jianting
authors.initials: J
authors.lastname: Wu
authors.affiliation: Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Cailing
authors.initials: C
authors.lastname: Li
authors.affiliation: Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
authors.forename: Liya
authors.initials: L
authors.lastname: Luo
authors.affiliation: Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Xia
authors.affiliation: Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Xianxin
authors.initials: X
authors.lastname: Li
authors.affiliation: Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Yaoting
authors.initials: Y
authors.lastname: Gui
authors.affiliation: Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Cai
authors.affiliation: Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
authors.forename: Zesong
authors.initials: Z
authors.lastname: Li
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics* / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D015996:Survival Rate; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics* / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D008565:Membrane Proteins; C000613547:TMEM52B protein, human; D051794:Von Hippel-Lindau Tumor Suppressor Protein; C497446:VHL protein, human
keywords: C12orf59; prognosis; renal cell cancer (RCC); survival; von Hippel-Lindau (VHL)