title: Antioxidant and Hepatoprotective Activities of Mycelia Selenium Polysaccharide by Hypsizigus marmoreus SK-02.
abstract: This work was designed to investigate the characteristic properties (bond types and monosaccharide compositions), and hepatoprotective effects on carbon tetrachloride (CCl4)-induced liver damage of mycelia selenium polysaccharides (MSPS) separated and purified from Hypsizigus marmoreus SK-02. Characteristic analysis of MSPS showed the selenium content (70.15 μg/g) in mycelia. The antioxidant activities in vitro demonstrated that MSPS had potential effects on scavenging reactive oxygen species and enhancing the reducing power. The treatment of MSPS for CCl4-induced animal experiment demonstrated that the MSPS could reduce the levels of malondiadehyde (MDA), lipid peroxide (LPO), glutamic oxalacetic transaminase (AST), and glutamic-pyruvic transaminase (ALT) activities and improve the levels of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), total cholesterol (TC), and triglyceride (TG) in serum/liver homogenate against CCl4-induced injures. Findings presented in this study clearly demonstrated that MSPS might be suitable for functional foods and natural drugs in preventing the CCl4-induced acute liver damage.
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: The Central Hospital of Taian, Taian, 271018, People's Republic of China.
authors.forename: Guangyuan
authors.initials: G
authors.lastname: Meng
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, People's Republic of China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, People's Republic of China.
authors.forename: Huajie
authors.initials: H
authors.lastname: Zhao
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, People's Republic of China. jiale0525@163.com.
authors.forename: Le
authors.initials: L
authors.lastname: Jia
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D012643:Selenium / Q000032:analysis / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D011134:Polysaccharides; D020011:Protective Agents; D002251:Carbon Tetrachloride; D012643:Selenium
keywords: Characterization; Hepatoprotective activities; Hypsizigus marmoreus SK-02; Mycelia selenium polysaccharide