title: Guidelines for genomic array analysis in acquired haematological neoplastic disorders.
abstract: Genetic profiling is important for disease evaluation and prediction of prognosis or responsiveness to therapy in neoplasia. Microarray technologies, including array comparative genomic hybridization and single-nucleotide polymorphism-detecting arrays, have in recent years been introduced into the diagnostic setting for specific types of haematological malignancies and solid tumours. It can be used as a complementary test or depending on the neoplasia investigated, also as a standalone test. However, comprehensive and readable presentation of frequently identified complex genomic profiles remains challenging. To assist diagnostic laboratories, standardization and minimum criteria for clinical interpretation and reporting of acquired genomic abnormalities detected through arrays in neoplastic disorders are presented.
authors.affiliation: Unité De Génétique Du Cancer, Service De Génétique Médicale, Centre Hospitalier Universitaire Vaudois, Lausanne, CH-1011, Switzerland.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Schoumans
authors.affiliation: Cytogenomics Laboratory, NIMGenetics, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Suela
authors.affiliation: Cytogenetic External Quality Assessment, Women's Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
authors.forename: Ros
authors.initials: R
authors.lastname: Hastings
authors.affiliation: Unité De Génétique Du Cancer, Service De Génétique Médicale, Centre Hospitalier Universitaire Vaudois, Lausanne, CH-1011, Switzerland.
authors.forename: Dominique
authors.initials: D
authors.lastname: Muehlematter
authors.affiliation: Institut De Pathologie Et De Génétique, Gosselies, Belgium.|West Midland Regional Genetic Laboratory, Birmingham Womens Hospital, Birmingham, UK.
authors.forename: Katrina
authors.initials: K
authors.lastname: Rack
authors.affiliation: Dept Genet, University Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
authors.forename: Eva
authors.initials: E
authors.lastname: van den Berg
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, the Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Berna Beverloo
authors.affiliation: Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands.
authors.forename: Marian
authors.initials: M
authors.lastname: Stevens-Kroef
mesh_terms: D056915:DNA Copy Number Variations; D017408:Guidelines as Topic; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis