title: Combined application of polyacrylate scaffold and lipoic acid treatment promotes neural tissue reparation after brain injury.
abstract: OBJECTIVE
  The aim of this study was to investigate the reparative potential of a polymeric scaffold designed for brain tissue repair in combination with lipoic acid.
  
  
  METHODS
  Histological, cytological and structural analysis of a combined treatment after a brain cryo-injury model in rats.
  
  
  METHODS
  Adult Wistar rats were subjected to cryogenic brain injury. A channelled-porous scaffold of ethyl acrylate and hydroxyethylacrylate, p(EA-co-HEA) was grafted into cerebral penumbra alone or combined with intraperitoneal LA administration. Histological and cytological evaluation was performed after 15 and 60 days and structural magnetic resonance (MRI) assessment was performed at 2 and 6 months after the surgery.
  
  
  RESULTS
  The scaffold was suitable for the establishment of different cellular types. The results obtained suggest that this strategy promotes blood vessels formation, decreased microglial response and neuron migration, particularly when LA was administrated.
  
  
  CONCLUSIONS
  These evidences demonstrated that the combination of a channelled polymer scaffold with LA administration may represent a potential treatment for neural tissue repair after brain injury.
authors.affiliation: a Facultad Ciencias de la Salud, Universidad CEU-Cardenal Herrera , Valencia , Spain.
authors.forename: Brenda
authors.initials: B
authors.lastname: Rocamonde
authors.affiliation: a Facultad Ciencias de la Salud, Universidad CEU-Cardenal Herrera , Valencia , Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Paradells
authors.affiliation: a Facultad Ciencias de la Salud, Universidad CEU-Cardenal Herrera , Valencia , Spain.
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Garcia Esparza
authors.affiliation: b Institut D'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS , Barcelona , Spain.
authors.forename: Mavi Sánchez
authors.initials: MS
authors.lastname: Vives
authors.affiliation: a Facultad Ciencias de la Salud, Universidad CEU-Cardenal Herrera , Valencia , Spain.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Sauro
authors.affiliation: c Centro de Biomateriales e Ingeniería Tisular, Universidad Politécnica de Valencia , Valencia , Spain.
authors.forename: Cristina Martínez
authors.initials: CM
authors.lastname: Ramos
authors.affiliation: c Centro de Biomateriales e Ingeniería Tisular, Universidad Politécnica de Valencia , Valencia , Spain.
authors.forename: Manuel Monleón
authors.initials: MM
authors.lastname: Pradas
authors.affiliation: a Facultad Ciencias de la Salud, Universidad CEU-Cardenal Herrera , Valencia , Spain.|d Instituto de Ciencias Biomédicas, Universidad CEU-Cardenal Herrera , Moncada , Valencia , Spain.
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Soria
mesh_terms: D000179:Acrylates / Q000627:therapeutic use*; D000687:Amylopectin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D001921:Brain / Q000473:pathology; D001930:Brain Injuries / Q000534:rehabilitation / Q000628:therapy; D000070642:Brain Injuries, Traumatic / Q000628:therapy*; D008297:Male; D010969:Plastics; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000627:therapeutic use*; D054457:Tissue Scaffolds
chemical_list: D000179:Acrylates; D010969:Plastics; C018317:hydroxyethylamylopectin; C040833:ethyl acrylate; D008063:Thioctic Acid; D000687:Amylopectin
keywords: Brain injury; biopolymers; lipoic acid; neural repairing; oxidative stress