title: Effect of increased ART-CPT uptake on tuberculosis outcomes and associated factors, Burundi, 2009-2013.
abstract: We retrospectively examined 3579 records of human immunodeficiency virus infected tuberculosis (TB) patients diagnosed from January 2009 to June 2013 in 55 TB treatment facilities in Burundi, to demonstrate whether improvement of combined cotrimoxazole preventive therapy and antiretroviral therapy (ART) uptake was accompanied by improvement of treatment outcomes, and to describe associated factors. Treatment success rates increased from 71% to 80% (P < 0.001). While loss to follow-up and transfer-out rates declined significantly, death rates decreased modestly, and remained high, at 14%. ART uptake was worse in suburban areas and private for-profit institutions. World Health Organization targets could be achieved if peripheral health facilities were prioritised.
authors.affiliation: Damien Foundation, Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Sawadogo
authors.affiliation: National Tuberculosis Control Programme, Ministry of Health, Bujumbura, Burundi.
authors.forename: F
authors.initials: F
authors.lastname: Ciza
authors.affiliation: National Tuberculosis Control Programme, Ministry of Health, Bujumbura, Burundi.
authors.forename: S D
authors.initials: SD
authors.lastname: Nzeyimana
authors.affiliation: National Antituberculosis Centre, Bujumbura, Burundi.
authors.forename: A
authors.initials: A
authors.lastname: Shingiro
authors.affiliation: National Tuberculosis Control Programme, Ministry of Health, Bujumbura, Burundi.
authors.forename: T
authors.initials: T
authors.lastname: Ndikumana
authors.affiliation: Damien Foundation, Brussels, Belgium.
authors.forename: T
authors.initials: T
authors.lastname: Demeulenaere
authors.affiliation: Médecins Sans Frontières, Operational Research Unit, Operational Centre Brussels, Luxembourg.
authors.forename: M
authors.initials: M
authors.lastname: Khogali
authors.affiliation: International Union Against Tuberculosis and Lung Disease (The Union), Paris, France ; School of Public Health, Faculty of Health Sciences, University of Witwaterstand, Johannesburg, South Africa.
authors.forename: M
authors.initials: M
authors.lastname: Edginton
authors.affiliation: Médecins Sans Frontières, Operational Research Unit, Operational Centre Brussels, Luxembourg.
authors.forename: A J
authors.initials: AJ
authors.lastname: Reid
authors.affiliation: The Union, South-East Asia Regional Office, New Delhi, India.
authors.forename: A M V
authors.initials: AM
authors.lastname: Kumar
authors.affiliation: International Union Against Tuberculosis and Lung Disease (The Union), Paris, France ; London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Harries
keywords: ART; Burundi; outcomes; tuberculosis; uptake