title: N-Heterocyclic carbene-catalyzed [3 + 2] annulation of bromoenals with 3-aminooxindoles: highly enantioselective synthesis of spirocyclic oxindolo-γ-lactams.
abstract: The chiral N-heterocyclic carbene-catalyzed [3 + 2] annulation of α-bromoenals and 3-aminooxindoles was developed, giving the corresponding spirocyclic oxindolo-γ-lactams in good yields with high diastereoselectivities and enantioselectivities.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. songye@iccas.ac.cn and Marine College, Shandong University at Weihai, 180 Wenhua West Road, Weihai 264209, China. dequn.sun@sdu.edu.cn.
authors.forename: Kun-Quan
authors.initials: KQ
authors.lastname: Chen
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. songye@iccas.ac.cn and Marine College, Shandong University at Weihai, 180 Wenhua West Road, Weihai 264209, China. dequn.sun@sdu.edu.cn.
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. songye@iccas.ac.cn.
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Zhang
authors.affiliation: Marine College, Shandong University at Weihai, 180 Wenhua West Road, Weihai 264209, China. dequn.sun@sdu.edu.cn.
authors.forename: De-Qun
authors.initials: DQ
authors.lastname: Sun
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. songye@iccas.ac.cn.
authors.forename: Song
authors.initials: S
authors.lastname: Ye
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D006842:Hydrocarbons, Brominated; D007211:Indoles; D007769:Lactams; D013141:Spiro Compounds; C030011:carbene; D008697:Methane