title: Extravascular lung water monitoring of renal replacement therapy in lung water scavenging for septic acute kidney injury.
abstract: This study aims to investigate the extravascular lung water index (EVLWI) in lung water scavenging of sepsis patients with acute kidney injury (AKI) by renal replacement therapy (RRT). 57 septic acute kidney injury patients with EVLWI > 7 ml/kg were selected and randomly divided into two groups: the treatment group with continued RRT for 24 h per day, the control group with RRT for ≤8 h per day. Fluid resuscitation and RRT were performed simultaneously. After fluid resuscitation, EVLWI, hemodynamics, oxygenation index, blood lactate, and intensive care unit (ICU) stay were determined. The values of EVLWI, pulmonary vascular permeability index (PVPI), and blood lactate decreased and the intrathoracic blood volume index (ITBVI) increased significantly at 24 h, 48 h and 72 h, after RRT, compared with those before RRT in the two groups (P < 0.05). The values of EVLWI at 48 h and 72 h after RRT in the treatment group were significantly lower than that in the control group (P < 0.05). The cardiac index (CI) at 48 h and 72 h after RRT in the treatment group was significantly higher than that before RRT (P < 0.05). The values of PVPI, ITBVI, CI, blood lactate, transcutaneous oxygen saturation pulse (SPO2), oxygenation index (PO2/FiO2) and arterial oxygen (PO2) before and 24 h, 48 h, and 72 h after RRT. The 28d mortality had no significant difference in the two groups (P > 0.05). The average ICU stay for the treatment group was significantly shorter than that of the control group (P < 0.05). EVLWI monitoring of septic patients with AKI in RRT time had clinical reference value.
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China.
authors.forename: Han
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China.
authors.forename: Jia-Kui
authors.initials: JK
authors.lastname: Sun
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China.
authors.forename: Qiao-Lian
authors.initials: QL
authors.lastname: Xu
authors.affiliation: Blood Purification Center, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Chen
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Hong
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Xu
keywords: Sepsis; acute kidney injury; extravascular lung water index; fluid resuscitation; pulse indicating continuous cardiac output; renal replacement therapy