title: Genetic risk factors of cisplatin induced ototoxicity in adult patients.
abstract: Ototoxicity is an important adverse effect of using Cisplatin (cis-diamminedichloroplatinum) (CDDP) as a form of chemotherapy. The clinical picture of CDDP induced ototoxicity includes perceptive hearing impairment (reversible or permanent) and tinnitus. Ototoxicity manifests with considerable variability between patients. The objective of this prospective study was to investigate a possible genetic background to this variability. We assessed ototoxicity induced by therapeutic doses of CDDP in adult patients with germinative testicular tumors, or other tumors treated with an identical CDDP dosage scheme. Audiological examination before, during and after the treatment has shown deterioration in hearing; first in the high-frequencies and with increased CDDP cumulative doses, impairment in other frequencies as well. Occurrence of tinnitus was not dependent on the administered dose of CDDP, or the other risk factors examined in this study. The association of CDDP induced ototoxicity with genetic polymorphisms in candidate genes was examined. Our study has demonstrated an association of early onset of CDDP induced ototoxicity with the presence of two copies of GSTT1 gene (p=0,009) and with T allele of rs9332377 polymorphism in COMT gene (p=0,001).
authors.forename: T
authors.initials: T
authors.lastname: Talach
authors.forename: J
authors.initials: J
authors.lastname: Rottenberg
authors.forename: B
authors.initials: B
authors.lastname: Gal
authors.forename: R
authors.initials: R
authors.lastname: Kostrica
authors.forename: M
authors.initials: M
authors.lastname: Jurajda
authors.forename: I
authors.initials: I
authors.lastname: Kocak
authors.forename: R
authors.initials: R
authors.lastname: Lakomy
authors.forename: E
authors.initials: E
authors.lastname: Vogazianos
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D056915:DNA Copy Number Variations / Q000235:genetics; D005260:Female; D018628:Gene Dosage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D034381:Hearing Loss / Q000139:chemically induced* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy; D011110:Polymorphism, Genetic / Q000235:genetics; D011446:Prospective Studies; D012307:Risk Factors; D014012:Tinnitus / Q000139:chemically induced* / Q000235:genetics*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: DNA copy number variations; cisplatin; ototoxicity; single nucleotide polymorphisms.