title: Major recanalization occurs more often in young patients after unruptured aneurysm coil embolization.
abstract: BACKGROUND
  The recanalization rate after coil embolization of unruptured aneurysms was compared between young and old age groups.
  
  
  METHODS
  From May 2003 to December 2010, 636 patients with 715 saccular unruptured intracranial aneurysms (UIA) underwent endovascular coiling and were followed for at least 6 months. For comparative analysis, patients were categorized into two groups according to age 40: 42 patients with 46 aneurysms who were 40 years or younger (young age group) and 594 patients with 669 aneurysms who were older than 40 years (old age group). Angiographic and clinical outcomes including recanalization rates were compared.
  
  
  RESULTS
  Angiographically, class 1 or 2 occlusion according to the Raymond-Roy Occlusion Classification system was achieved in 89.2 % of the patients (91.3 % in the young age group and 89.1 % in the old age group, p = 0.74). Procedure-related complication rate was 2.2 % and 3.4 % in the young and the old age group (p = 0.16), respectively. The mean follow-up duration was 30.51 ± 18.59 months. Major recanalization occurred in seven aneurysms (15.2 %) in the young age group and in 44 aneurysms (6.6 %) in the old age group (p = 0.03). Retreatment was performed in seven patients (15.2 %) in the young age group and in 35 patients (5.2 %) in the old age group (p = 0.01).
  
  
  CONCLUSIONS
  The present study showed that the technical feasibility and safety of endovascular coiling for UIA did not differ between the two age groups. However, the major recanalization rate was higher in the young age group.
authors.affiliation: Department of Neurosurgery, Seoul National University Boramae Medical Center, Seoul, South Korea.
authors.forename: Young-Je
authors.initials: YJ
authors.lastname: Son
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, 463-707, Seongnam, Gyeonggido, South Korea. meurokwonoki@gmail.com.
authors.forename: O-Ki
authors.initials: OK
authors.lastname: Kwon
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, 463-707, Seongnam, Gyeonggido, South Korea.
authors.forename: Gyojun
authors.initials: G
authors.lastname: Hwang
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, 463-707, Seongnam, Gyeonggido, South Korea.
authors.forename: Nam Mi
authors.initials: NM
authors.lastname: Park
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, 463-707, Seongnam, Gyeonggido, South Korea.
authors.forename: Chang Wan
authors.initials: CW
authors.lastname: Oh
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, 463-707, Seongnam, Gyeonggido, South Korea.
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Bang
mesh_terms: D000328:Adult; D000368:Aged; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D004621:Embolization, Therapeutic / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019233:Retreatment / Q000706:statistics & numerical data
keywords: Endovascular coiling; Recanalization; Unruptured intracranial aneurysm; Young age