title: [Progress in sample preparation and analytical methods for trace polar small molecules in complex samples].
abstract: Small polar molecules such as nucleosides, amines, amino acids are important analytes in biological, food, environmental, and other fields. It is necessary to develop efficient sample preparation and sensitive analytical methods for rapid analysis of these polar small molecules in complex matrices. Some typical materials in sample preparation, including silica, polymer, carbon, boric acid and so on, are introduced in this paper. Meanwhile, the applications and developments of analytical methods of polar small molecules, such as reversed-phase liquid chromatography, hydrophilic interaction chromatography, etc., are also reviewed.
authors.forename: Qianchun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xialin
authors.initials: X
authors.lastname: Luo
authors.forename: Gongke
authors.initials: G
authors.lastname: Li
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Xiao
mesh_terms: D000588:Amines / Q000032:analysis*; D000596:Amino Acids / Q000032:analysis*; D002845:Chromatography / Q000379:methods*; D056148:Chromatography, Reverse-Phase; D057927:Hydrophobic and Hydrophilic Interactions; D009705:Nucleosides / Q000032:analysis*; D012822:Silicon Dioxide
chemical_list: D000588:Amines; D000596:Amino Acids; D009705:Nucleosides; D012822:Silicon Dioxide