title: The effect of inflammatory cytokines and the level of vitamin D on prognosis in Crimean-Congo hemorrhagic fever.
abstract: Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease. Its pathogenesis basically involves endothelial damage. The aim of this study was to determine serum IL2, IL6, IL 10 and 25 OH Vitamin D levels in patients with CCHF and also to reveal their role in the clinical course and prognosis of the disease. Diagnosis of CCHF was confirmed using the positive polymerase chain reaction (PCR) test and/or positive IgM antibody by enzyme-linked immunosorbent assay (ELISA). Serum IL-2, IL-6, IL-10 and total 25 OH Vitamin D levels were also measured using ELISA. Eighty CCHF patients and 110 healthy controls were enrolled. IL2, IL6 and IL10 levels were significantly higher in the patient group. IL 6 and IL 10 levels were significantly higher in the fatal group. There was a positive correlation between Vitamin D and AST (r=0.402; P<0.001), and another positive correlation between IL-6 and CK (r=0.714; P<0.001). High IL6 and L10 levels are a significant indicator of fatality. Cytokines are only one of the factors responsible for mortality. We conclude that the pathogenesis of the disease can be better understood by elucidating the complicated cytokine network.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Atatürk University Faculty of Medicine Erzurum, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Parlak
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Recep Tayyip Erdoğan University Faculty of Medicine Rize, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Ertürk
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Lütfi Kırdar Training and Research Hospital İstanbul, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Çağ
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Atatürk University Erzurum, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Sebin
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Atatürk University Erzurum, Turkey.
authors.forename: Musa
authors.initials: M
authors.lastname: Gümüşdere
keywords: Crimean-Congo hemorrhagic fever; cytokine; fatality; vitamin D Introduction