title: [Expressions of interleukin-21 and interleukin-22 in Kimura's disease].
abstract: OBJECTIVE
  To investigate the expressions of interleukin (IL)-21 (IL-21) and IL-22 in patients with Kimura's disease (KD).
  
  
  METHODS
  Expressions of IL-21 and IL-22 were examined immunohistochemically in 36 patients with KD and 7 normal controls. The integral absorbance (IA) of the two groups was compared. Meanwhile, clinical data were reviewed.
  
  
  RESULTS
  The IA of IL-21 [M(Q): 1 373 418 (1 800 926)] and IL-22 [M(Q): 462 086(484 672)] in KD was significantly higher than those in normal controls [M(Q): 70 445(44 658), 51 599(71 241), P < 0.05]. The overexpression of IL-21 was significantly associated with pruritus (Z = -1.993, P < 0.05). Moreover, IL-21 was identified for disease recurrence (Z = -2.303, P < 0.05). There was a significant association between the expression of IL-22 and the number of affected sites (Z = -1.979, P < 0.05). In addition, IL-22 was significantly higher in the high-eosinophils group than in the low-eosinophils group (Z = -2.025, P < 0.05). There was no association between IL-21, IL-22 and age, gender, laterality, maximum size.
  
  
  CONCLUSIONS
  IL-21 and IL-22 may be involved in the pathogenesis of KD.
authors.affiliation: Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Hu
authors.affiliation: Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China; Email: gump0904@aliyun.com.
authors.forename: Zhongcheng
authors.initials: Z
authors.lastname: Gong
authors.affiliation: Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Dwa
authors.initials: D
authors.lastname: Srijana
authors.affiliation: Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Yin
authors.affiliation: Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Zhaoquan
authors.initials: Z
authors.lastname: Lin
mesh_terms: D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000378:metabolism*; D016022:Case-Control Studies; D004804:Eosinophils; D006801:Humans; D007378:Interleukins / Q000378:metabolism*; D007958:Leukocyte Count; D011537:Pruritus / Q000378:metabolism; D012008:Recurrence; D000097043:Interleukin-22; D000098546:Interleukin-21
chemical_list: D007378:Interleukins; D000097043:Interleukin-22; D000098546:Interleukin-21