title: Acrosome markers of human sperm.
abstract: Molecular biomarkers that can assess sperm acrosome status are very useful for evaluating sperm quality in the field of assisted reproductive technology. In this review, we introduce and discuss the localization and function of acrosomal proteins that have been well studied. Journal databases were searched using keywords, including "human acrosome", "localization", "fertilization-related protein", "acrosomal membrane", "acrosomal matrix", "acrosome reaction", "knockout mouse", and "acrosome marker".
authors.affiliation: Department of Reproductive Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan. chizuru@faculty.chiba-u.jp.
authors.forename: Chizuru
authors.initials: C
authors.lastname: Ito
authors.affiliation: Department of Reproductive Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Toshimori
mesh_terms: D051722:ADAM Proteins; D000176:Acrosin; D000177:Acrosome / Q000502:physiology; D020101:Acrosome Reaction; D000818:Animals; D000941:Antigens; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D004527:Egg Proteins; D004792:Enzyme Precursors; D005306:Fertilization; D006023:Glycoproteins; D006801:Humans; D007136:Immunoglobulins; D007519:Isoantigens; D008297:Male; D051916:Membrane Cofactor Protein; D008565:Membrane Proteins; D051379:Mice; D011956:Receptors, Cell Surface; D029589:Seminal Plasma Proteins; D013094:Spermatozoa / Q000502:physiology
chemical_list: C512729:ACRV1 protein, human; D000941:Antigens; C497857:CD46 protein, human; C062621:CRISP2 protein, human; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D004527:Egg Proteins; D004792:Enzyme Precursors; C512717:Eqtn protein, mouse; D006023:Glycoproteins; C498176:IZUMO1 protein, human; D007136:Immunoglobulins; D007519:Isoantigens; D051916:Membrane Cofactor Protein; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; C455113:SPACA1 protein, human; C490560:SPACA3 protein, human; C484958:SPESP1 protein, human; D029589:Seminal Plasma Proteins; C572207:ZPBP1 protein, human; C403409:acrin 1; C094480:sp56 protein, mouse; C096806:zonadhesin; C022438:proacrosin; D000176:Acrosin; D051722:ADAM Proteins; C499566:ADAM3A protein, human
keywords: Acrosomal matrix; Acrosomal membrane; Acrosome marker; Acrosome reaction; Fertilization-related protein; Human acrosome