title: Functional and prognostic relevance of -173 G/C gene polymorphism of macrophage migration inhibitory factor in sepsis patients in Egyptian intensive care units.
abstract: This study aimed to evaluate the association of plasma MIF level and -173 G/C single nucleotide polymorphism of the MIF gene with the occurrence, severity and mortality of sepsis patients. A study was conducted in adult surgical intensive care units of Zagazig University Hospitals, Egypt on 25 patients with sepsis, 27 with severe sepsis and 28 controls. Gram-negative bacilli were the most common isolates in both severe sepsis (63.0%) and sepsis (56.0%) patients. A highly statistically significant difference was found in MIF levels between sepsis cases and controls and a statistically significant difference as regards MIF level in different genotypes of the studied groups. MIF level was significantly associated with mortality in sepsis cases. High MIF levels and MIF -173G/C gene polymorphism are powerful predictors of the severity of sepsis and its outcome.
authors.affiliation: Department of Microbiology and Immunology, Zagazig University Hospitals, Zagazig, Egypt.
authors.forename: T E
authors.initials: TE
authors.lastname: Meawed
authors.affiliation: Department of Microbiology and Immunology, Zagazig University Hospitals, Zagazig, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Mansour
authors.affiliation: Department of Microbiology and Immunology, Zagazig University Hospitals, Zagazig, Egypt.
authors.forename: S A
authors.initials: SA
authors.lastname: Mansour
authors.affiliation: Department of Obstetrics and Gynaecology, Zagazig University Hospitals, Zagazig, Egypt.
authors.forename: M L
authors.initials: ML
authors.lastname: Mohamed
authors.affiliation: Department of General Surgery, Zagazig University Hospitals, Zagazig, Egypt.
authors.forename: E M
authors.initials: EM
authors.lastname: Ibrahim
authors.affiliation: Department of Anaesthesiology and Intensive Care, Zagazig University Hospitals, Zagazig, Egypt.
authors.forename: A M
authors.initials: AM
authors.lastname: Ali
mesh_terms: D000328:Adult; D000368:Aged; D004534:Egypt / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D007362:Intensive Care Units; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D018805:Sepsis / Q000097:blood / Q000235:genetics* / Q000382:microbiology / Q000401:mortality
chemical_list: D008263:Macrophage Migration-Inhibitory Factors