title: Exploitation of novel gum Prunus cerasoides as mucoadhesive beads for a controlled-release drug delivery.
abstract: The present study deals with the formulation of pH-sensitive mucoadhesive beads using natural gum isolated from Prunus cerasoides (PC) in combination with sodium alginate (SA) for the controlled release of diclofenac sodium (DS). PC and SA composite (PC-SA), DS loaded SA (DS-SA) and DS loaded PC-SA (DS-PC-SA) beads were prepared by ionotropic gelation method. The absence of interaction between DS and PC-SA was shown by FTIR, DSC and TGA analyses. The optimized DS-PC-SA formulation exhibited mucoadhesive property and the controlled release of DS was achieved 68% in 12h. The in vitro release kinetics follows zero order with anomalous diffusion mechanism. Therefore, the formulated mucoadhesive beads with the novel gum are preferable for the controlled release of DS by prolonging the residence time of the drug in the gastrointestinal tract, overcoming the problems associated with the immediate release dosage forms of DS.
authors.affiliation: Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India.
authors.forename: T Veenus
authors.initials: TV
authors.lastname: Seelan
authors.affiliation: Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India; National Facility for Drug Development (NFDD) for Academia, Pharmaceutical and Allied Industries, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India.
authors.forename: Henry Linda Jeeva
authors.initials: HL
authors.lastname: Kumari
authors.affiliation: Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India.
authors.forename: Narra
authors.initials: N
authors.lastname: Kishore
authors.affiliation: Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India; National Facility for Drug Development (NFDD) for Academia, Pharmaceutical and Allied Industries, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India.
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Selvamani
authors.affiliation: Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences (RIPANS), Zemabawk, Aizawl 796017, Mizoram, India.
authors.forename: H
authors.initials: H
authors.lastname: Lalhlenmawia
authors.affiliation: Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences (RIPANS), Zemabawk, Aizawl 796017, Mizoram, India.
authors.forename: K
authors.initials: K
authors.lastname: Thanzami
authors.affiliation: Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences (RIPANS), Zemabawk, Aizawl 796017, Mizoram, India; Department of Pharmaceutical Sciences, Assam University, Silchar 788011, Assam, India. Electronic address: aduhapc@gmail.com.
authors.forename: Lalduhsanga
authors.initials: L
authors.lastname: Pachuau
authors.affiliation: Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India; National Facility for Drug Development (NFDD) for Academia, Pharmaceutical and Allied Industries, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India. Electronic address: hodpharma@gmail.com.
authors.forename: Kandasamy
authors.initials: K
authors.lastname: Ruckmani
mesh_terms: D000464:Alginates / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008863:Microspheres; D009092:Mucous Membrane / Q000187:drug effects / Q000378:metabolism; D010316:Particle Size; D053149:Plant Gums / Q000737:chemistry*; D027861:Prunus / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013818:Thermogravimetry
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D053149:Plant Gums; D020723:Glucuronic Acid
keywords: Controlled drug release; Mucoadhesion; Prunus cerasoides