title: Synthesis, characterization and antibacterial assessment of SiO2-hydroxypropylmethyl cellulose hybrid materials with embedded silver nanoparticles.
abstract: Antibacterial SiO2hybrid materials based on tetraethyl orthosilicate (TEOS), hydroxypropylmethylcellulose (HPMC) and silver were prepared by the sol-gel method. The content of cellulose derivate was 5 wt% and the silver concentration varied from 0.5 wt% to 2.5 wt%. The amorphous nature, morphology and antibacterial behaviour were studied. Fourier transform infrared (FTIR) spectra of the hybrids showed characteristic peaks for SiO2network. Scanning electron microscope (SEM) analysis confirmed the formation of spherically shaped silver nanoparticles with a size of 30 nm on the matrix surfaces.Bacillus subtilisandEscherichia coliK12 were used as model microorganisms. The hybrid materials demonstrated bacteriostatic and bactericidal effect on the tested bacteria. Highest sensitivity to the obtained hybrids was observed inB. subtiliswith significant lag-phase delay and biggest inhibition zone sizes.
authors.affiliation: Department of Biotechnology, University of Chemical Technology and Metallurgy , Sofia , Bulgaria.
authors.forename: Tsvetelina
authors.initials: T
authors.lastname: Angelova
authors.affiliation: Department of Fundamentals of Chemical Technology, University of Chemical Technology and Metallurgy , Sofia , Bulgaria.
authors.forename: Nadezhda
authors.initials: N
authors.lastname: Rangelova
authors.affiliation: Department of Biotechnology, University of Chemical Technology and Metallurgy , Sofia , Bulgaria.
authors.forename: Hristina
authors.initials: H
authors.lastname: Dineva
authors.affiliation: Department of Biotechnology, University of Chemical Technology and Metallurgy , Sofia , Bulgaria.
authors.forename: Nelly
authors.initials: N
authors.lastname: Georgieva
authors.affiliation: Institute of Technical Biocatalysis, Hamburg University of Technology , Hamburg , Germany.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Müller
keywords: SiO2; antibacterial activity; hydroxypropylmethyl cellulose; silver nanoparticles