title: Synthesis of 3-alkyl spiro[4,5]trienones by copper-catalyzed oxidative ipso-annulation of activated alkynes with unactivated alkanes.
abstract: A Cu-catalyzed oxidative ipso-annulation of activated alkynes with unactivated alkanes for the synthesis of 3-alkyl spiro[4,5]trienones is described. This method allows the formation of two carbon-carbon bonds and one carbon-oxygen bond in a single reaction through a sequence of C-H oxidative coupling, ipso-carbocyclization and dearomatization.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. srj0731@hnu.edu.cn jhli@hnu.edu.cn.
authors.forename: Xuan-Hui
authors.initials: XH
authors.lastname: Ouyang
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Song
authors.forename: Bang
authors.initials: B
authors.lastname: Liu
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li