title: Flow-Driven Cell Migration under External Electric Fields.
abstract: Electric fields influence many aspects of cell physiology, including various forms of cell migration. Many cells are sensitive to electric fields, and they can migrate toward a cathode or an anode, depending on the cell type. In this Letter, we examine an actomyosin-independent mode of cell migration under electrical fields. Our theory considers a one-dimensional cell with water and ionic fluxes at the cell boundary. Water fluxes through the membrane are governed by the osmotic pressure difference across the cell membrane. Fluxes of cations and anions across the cell membrane are determined by the properties of the ion channels as well as the external electric field. Results show that without actin polymerization and myosin contraction, electric fields can also drive cell migration, even when the cell is not polarized. The direction of migration with respect to the electric field direction is influenced by the properties of ion channels, and are cell-type dependent.
authors.affiliation: Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors.forename: Yizeng
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Mathematics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Mori
authors.affiliation: Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.|Johns Hopkins Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors.forename: Sean X
authors.initials: SX
authors.lastname: Sun
mesh_terms: D000205:Actomyosin / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D004574:Electromagnetic Fields; D007473:Ion Channels / Q000378:metabolism; D008954:Models, Biological; D009997:Osmotic Pressure; D014867:Water / Q000378:metabolism
chemical_list: D007473:Ion Channels; D014867:Water; D000205:Actomyosin