title: Mechanisms of Stress-Induced Visceral Pain: Implications in Irritable Bowel Syndrome.
abstract: Visceral pain is a term describing pain originating from the internal organs of the body and is a common feature of many disorders, including irritable bowel syndrome (IBS). Stress is implicated in the development and exacerbation of many visceral pain disorders. Recent evidence suggests that stress and the gut microbiota can interact through complementary or opposing factors to influence visceral nociceptive behaviours. The Young Investigator Forum at the International Society of Psychoneuroendocrinology (ISPNE) annual meeting reported experimental evidence suggesting the gut microbiota can affect the stress response to affect visceral pain. Building upon human imaging data showing abnormalities in the central processing of visceral stimuli in patients with IBS and knowledge that the amygdala plays a pivotal role in facilitating the stress axis, the latest experimental evidence supporting amygdala-mediated mechanisms in stress-induced visceral pain was reviewed. The final part of the session at ISPNE reviewed experimental evidence suggesting that visceral pain in IBS may be a result, at least in part, of afferent nerve sensitisation following increases in epithelial permeability and mucosal immune activation.
authors.affiliation: Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.|V.A. Medical Center, Oklahoma City, OK, USA.
authors.forename: B
authors.initials: B
authors.lastname: Greenwood-Van Meerveld
authors.affiliation: Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Moloney
authors.affiliation: Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Johnson
authors.affiliation: Department of Gastroenterology, Neuro-immuno-gastroenterology Laboratory, Digestive Diseases Research Unit, Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron & Universitat Autònoma de Barcelona, Barcelona, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Vicario
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000503:physiopathology; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000503:physiopathology*; D059225:Nociception / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*; D059265:Visceral Pain / Q000150:complications / Q000503:physiopathology*
keywords: amygdala; corticotrophin-releasing hormone; irritable bowel syndrome; mucosal immunity; stress; visceral hypersensitivity