title: Evaluation of the role of the cannabidiol system in an animal model of ischemia/reperfusion kidney injury.
abstract: OBJECTIVE
  This work aimed to investigate the effects of the administration of cannabidiol in a kidney ischemia/reperfusion animal model.
  
  
  METHODS
  Kidney injury was induced by 45 minutes of renal ischemia followed by reperfusion. Cannabidiol (5mg/kg) was administered immediately after reperfusion.
  
  
  RESULTS
  Ischemia/reperfusion increased the IL-1 and TNF levels, and these levels were attenuated by cannabidiol treatment. Additionally, cannabidiol was able to decrease lipid and protein oxidative damage, but not the nitrite/nitrate levels. Kidney injury after ischemia/reperfusion seemed to be independent of the cannabidiol receptor 1 and cannabidiol receptor 2 (CB1 and CB2) expression levels, as there was no significant increase in these receptors after reperfusion.
  
  
  CONCLUSIONS
  The cannabidiol treatment had a protective effect against inflammation and oxidative damage in the kidney ischemia/reperfusion model. These effects seemed to be independent of CB1/CB2 receptor activation.
authors.affiliation: Laboratório de Fisiopatologia Experimental, Programa de Graduação em Ciências da Saúde, Unidade de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
authors.forename: Rodrigo Zon
authors.initials: RZ
authors.lastname: Soares
authors.affiliation: Laboratório de Fisiopatologia Experimental, Programa de Graduação em Ciências da Saúde, Unidade de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
authors.forename: Francieli
authors.initials: F
authors.lastname: Vuolo
authors.affiliation: Laboratório de Fisiopatologia Experimental, Programa de Graduação em Ciências da Saúde, Unidade de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
authors.forename: Dhébora Mozena
authors.initials: DM
authors.lastname: Dall'Igna
authors.affiliation: Laboratório de Fisiopatologia Experimental, Programa de Graduação em Ciências da Saúde, Unidade de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
authors.forename: Monique
authors.initials: M
authors.lastname: Michels
authors.affiliation: Departamento de Neurociências e Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: José Alexandre de Souza
authors.initials: JA
authors.lastname: Crippa
authors.affiliation: Departamento de Neurociências e Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Jaime Eduardo Cecílio
authors.initials: JE
authors.lastname: Hallak
authors.affiliation: Departamento de Neurociências e Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Antonio Waldo
authors.initials: AW
authors.lastname: Zuardi
authors.affiliation: Laboratório de Fisiopatologia Experimental, Programa de Graduação em Ciências da Saúde, Unidade de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
mesh_terms: D000818:Animals; D002185:Cannabidiol / Q000494:pharmacology*; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology; D007375:Interleukin-1 / Q000378:metabolism; D007674:Kidney Diseases / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism; D043885:Receptor, Cannabinoid, CB2 / Q000378:metabolism; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2; D014409:Tumor Necrosis Factor-alpha; D002185:Cannabidiol