title: Dual Antiplatelet Therapy in Patients with Stable Ischemic Heart Disease.
abstract: Dual antiplatelet therapy (DAPT) is the use of a P2Y12 receptor antagonist (clopidogrel, prasugrel, or ticagrelor) in combination with aspirin. Recommendations for its use are primarily in patients who have experienced acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) in the preceding 12 months. There is a growing body of evidence, however, investigating the use of long-duration DAPT in patients with stable ischemic heart disease (SIHD). SIHD is defined as clinical evidence of ischemic heart disease, without an ACS event in the preceding 12 months, and includes patients with stable angina, elective PCI, and remote history of ACS. The use of DAPT in the SIHD population and the recent advancements in our understanding of its use are the focus of this review.
authors.affiliation: Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.|Department of Medicine, Denver Health Hospital Authority, Denver, CO, USA.
authors.forename: Joseph Walker
authors.initials: JW
authors.lastname: Keach
authors.affiliation: Richard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Yeh
authors.affiliation: Cardiology Section, Veterans Affairs Eastern Colorado Health Care System, 1055 Clermont Street, Mail Stop 111B, Denver, CO, 80220, USA. thomas.maddox@va.gov.|Department of Medicine (Cardiology), University of Colorado School of Medicine, Aurora, CO, USA. thomas.maddox@va.gov.|Colorado Cardiovascular Outcomes Research (CCOR) Consortium, Denver, CO, USA. thomas.maddox@va.gov.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Maddox
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D015201:Meta-Analysis as Topic; D017202:Myocardial Ischemia / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
keywords: Aspirin; Clopidogrel; Coronary artery disease; Dual antiplatelet therapy; Myocardial infarction; Prasugrel; Stable ischemic heart disease; Ticagrelor