title: [RESEARCH PROGRESS OF ENDOTHELIAL PROGENITOR CELLS DERIVED EXTRACELLULAR VESICLES].
abstract: OBJECTIVE
  To review the current progresses in purification strategies, biological characters, and functions of endothelial progenitor cells (EPCs) derived extracellular vesicles (EVs) (EPC-EVs).
  
  
  METHODS
  Recent relevant publications on the EPC-EVs were extensively reviewed, analyzed, and summarized.
  
  
  RESULTS
  EPC-EVs are usually isolated by differential centrifugation and exhibit a homogenous pattern of spheroid particles with a diameter ranging from 60 to 160 nm under transmission electron microscopy. EPC-EVs are positive for cell-surface markers of EPCs (CD31, CD34, and CD133), and negative for markers of platelets (P-selectin and CD42b) and monocytes (CD14). Recent studies have shown the effectiveness of EPC-EVs in ischemic injuries, anti-Thyl glomerulonephritis, and cardiomyocyte hypertrophy, and also shown their predictive role in cardio-cerebral-vascular diseases.
  
  
  CONCLUSIONS
  An alluring prospect exists on the EPC-EVs-related research. Further studies are required to decipher the composition of EPC-EVs and their precise role in pathophysiological processes, and to investigate the molecular mechanisms for their targeting and function.
authors.forename: Chunyuan
authors.initials: C
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D015415:Biomarkers; D002454:Cell Differentiation; D066026:Endothelial Progenitor Cells; D000067128:Extracellular Vesicles; D006801:Humans; D009000:Monocytes; D019007:P-Selectin
chemical_list: D015415:Biomarkers; D019007:P-Selectin; C546937:SELP protein, human