title: Adult Neurogenesis in Fish.
abstract: Teleost fish have a remarkable neurogenic and regenerative capacity in the adult throughout the rostrocaudal axis of the brain. The distribution of proliferation zones shows a remarkable conservation, even in distantly related teleost species, suggesting a common teleost ground plan of proliferation zones. There are different progenitor populations in the neurogenic niches-progenitors positive for radial glial markers (dorsal telencephalon, hypothalamus) and progenitors with neuroepithelial-like characteristics (ventral telencephalon, optic tectum, cerebellum). Definition of these progenitors has allowed studying their role in normal growth of the adult brain, but also when challenged following a lesion. From these studies, important roles have emerged for intrinsic mechanisms and extrinsic signals controlling the activation of adult neurogenesis that enable regeneration of the adult brain to occur, opening up new perspectives on rekindling regeneration also in the context of the mammalian brain.
authors.affiliation: Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403.
authors.forename: Julia
authors.initials: J
authors.lastname: Ganz
authors.affiliation: Biotechnology Center, and DFG-Research Center for Regenerative Therapies Dresden, Technische Universität Dresden, 01307 Dresden, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Brand
mesh_terms: D000818:Animals; D005399:Fishes / Q000145:classification / Q000502:physiology*; D055495:Neurogenesis; D010802:Phylogeny