title: Antimicrobial Diterpenes from Azorella Species Against Gram-Positive Bacteria.
abstract: The present study was aimed at evaluating the antibacterial activity of mulinane and azorellane diterpenes isolated from the Andean plants Azorella compacta and A. trifoliolata and semisynthetic derivatives against reference and multidrug-resistant strains. The results revealed that the semisynthetic compound 7-acetoxy-mulin-9,12-diene (5) exhibited antibacterial activity against reference and multidrug-resistant strains of Staphylococcus aureus and moderate antimycobacterial activity against Mycobacterium smegmatis ATCC 14468.
authors.forename: Viviana
authors.initials: V
authors.lastname: Donoso
authors.forename: Mitchell
authors.initials: M
authors.lastname: Bacho
authors.forename: Solange
authors.initials: S
authors.lastname: Núiñez
authors.forename: Juana
authors.initials: J
authors.lastname: Rovirosa
authors.forename: Aurelio
authors.initials: A
authors.lastname: San-Martin
authors.forename: Sergio
authors.initials: S
authors.lastname: Leiva
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts