title: Association of MMP-2 gene haplotypes with thoracic aortic dissection in chinese han population.
abstract: BACKGROUND
  Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population.
  
  
  METHODS
  In our case-control study, we recruited 755 unrelated participants: 315 case participants with TAD and 440 controls. Twenty-two tag SNPs were selected from MMP-2 gene and were genotyped. Genotype data were analyzed by logistic regression.
  
  
  RESULTS
  Although we did not find any significant association for MMP-2 SNPs using single-marker analysis, we identified many windows with haplotype frequencies significantly different between case participants and control participants using a variable-sized sliding-window strategy. In particular, the most significant association was shown by a 2-SNP window consisting of rs2241145 and rs9928731 (omnibus test: asymptotic Pasym = 7.48 × 10 (-5) and empirical Pemp = 0.001867). There were two protective haplotypes: CT (Pasym = 0.00303; odds ratio [OR], 0.403) and GC (Pasym = 0.000976; OR, 0.448).
  
  
  CONCLUSIONS
  MMP-2 haplotypes are associated with genetic susceptibility to thoracic aortic dissection in Chinese Han population.
authors.affiliation: Department of Cardiovascular Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, 100029, China.
authors.forename: Ou
authors.initials: O
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, 100029, China.
authors.forename: Jiachen
authors.initials: J
authors.lastname: Li
authors.affiliation: Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 100029, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xin
authors.affiliation: Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 100029, China.
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Department of Cardiovascular Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, 100029, China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, 100029, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Gong
authors.affiliation: Department of Cardiovascular Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, 100029, China.
authors.forename: Yuyong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, 100029, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiovascular Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, 100029, China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, 100029, China. anzhenzhj@163.com.
authors.forename: Hongjia
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000784:Aortic Dissection / Q000235:genetics*; D017545:Aortic Aneurysm, Thoracic / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2