title: Analysis of the Relationship Between ADIPOR1 Variants and the Susceptibility of Chronic Metabolic Diseases in a Northeast Han Chinese Population.
abstract: OBJECTIVE
  Shared genetic variants in ADIPOR1 have been identified as closely related to coronary artery disease (CAD), type 2 diabetes (T2D), and T2D with CAD susceptibility, suggesting that these variants are strong candidates for the common soil hypothesis. Therefore, it is essential to analyze the relationship between ADIPOR1 variants and the susceptibility to CAD, T2D, and T2D with CAD in other populations.
  
  
  METHODS
  A case-control study was conducted which included three case cohorts [CAD (n = 316), T2D (n = 295), T2D with CAD (n = 302)], and a control cohort (n = 268) from a population in northeast China. Six ADIPOR1 single-nucleotide polymorphisms were genotyped by high-resolution melting and polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  We confirmed that the shared variant, rs3737884*G, in ADIPOR1 is associated with CAD, T2D, and T2D with CAD (p-value range: 6.54E-6-1.82E-5, odds ratio [OR] range: 1.770-1.844) and that rs16850797*C is associated with T2D and T2D with CAD (p-value range: 0.001-0.001, OR range: 1.529-1.571). We also found that a novel shared variant, rs7514221*C, is associated with an increased susceptibility to CAD, T2D, and T2D with CAD (p-value range: 0.002-0.004, OR range: 1.194-2.382) in this population.
  
  
  CONCLUSIONS
  ADPOR1 variants, rs3737884*G and rs7514221*C, may be shared risk factors associated with CAD, T2D, and T2D with CAD in a population of northeast China.
authors.affiliation: 1 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics , Chinese Ministry of Health, Beijing, China .|2 Department of Geriatrics, the First Affiliated Hospital of Jiamusi University , Jiamusi, China .
authors.forename: Fengling
authors.initials: F
authors.lastname: Wang
authors.affiliation: 1 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics , Chinese Ministry of Health, Beijing, China .|3 Clinical Medical School, Jiamusi University , Jiamusi, China .
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Suo
authors.affiliation: 1 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics , Chinese Ministry of Health, Beijing, China .
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.affiliation: 4 Department of Cardiology, the First Affiliated Hospital of Jiamusi University , Jiamusi, China .
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: 1 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics , Chinese Ministry of Health, Beijing, China .
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: 1 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics , Chinese Ministry of Health, Beijing, China .
authors.forename: Chengxiao
authors.initials: C
authors.lastname: Zhao
authors.affiliation: 3 Clinical Medical School, Jiamusi University , Jiamusi, China .
authors.forename: Xuejie
authors.initials: X
authors.lastname: Li
authors.affiliation: 3 Clinical Medical School, Jiamusi University , Jiamusi, China .
authors.forename: Ludan
authors.initials: L
authors.lastname: Yuan
authors.affiliation: 3 Clinical Medical School, Jiamusi University , Jiamusi, China .
authors.forename: Shuqian
authors.initials: S
authors.lastname: Yu
authors.affiliation: 3 Clinical Medical School, Jiamusi University , Jiamusi, China .
authors.forename: Tao
authors.initials: T
authors.lastname: Qi
authors.affiliation: 1 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics , Chinese Ministry of Health, Beijing, China .
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Zhu
authors.affiliation: 1 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics , Chinese Ministry of Health, Beijing, China .
authors.forename: Huiping
authors.initials: H
authors.lastname: Yuan
authors.affiliation: 5 Department of Emergency Medicine, Anzhen Hospital, Capital Medical University , Beijing Institute of Heart Lung and Blood Vessels, Beijing, China .
authors.forename: Zening
authors.initials: Z
authors.lastname: Jin
authors.affiliation: 5 Department of Emergency Medicine, Anzhen Hospital, Capital Medical University , Beijing Institute of Heart Lung and Blood Vessels, Beijing, China .
authors.forename: Lianmei
authors.initials: L
authors.lastname: Pu
authors.affiliation: 1 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics , Chinese Ministry of Health, Beijing, China .
authors.forename: Deping
authors.initials: D
authors.lastname: Liu
authors.affiliation: 2 Department of Geriatrics, the First Affiliated Hospital of Jiamusi University , Jiamusi, China .
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Sui
authors.affiliation: 1 The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics , Chinese Ministry of Health, Beijing, China .
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054419:Receptors, Adiponectin / Q000235:genetics*
chemical_list: C475418:ADIPOR1 protein, human; D054419:Receptors, Adiponectin