title: Middle cerebral artery Doppler in prediction degree of fetal anemia and the best timing for the second intrauterine intravascular transfusion in red cell alloimmune disease.
abstract: OBJECTIVE
  To determine the role of fetal multiples of the median of middle cerebral artery peak systolic velocity (MoM MCA-PSV), predicts the rate of decline in fetal hematocrit (Hct) for determination of the best timing for the second intrauterine intravascular transfusion (IUIVT) in fetuses with Rh alloimmunisation.
  
  
  METHODS
  Retrospective study of 59-monofetal alloimmunized pregnancies from 2005 to 2012 that underwent first and second IUIVT were assessed in Department of Gynecology and Obstetrics, Belgrade, Serbia.
  
  
  RESULTS
  There was an inverse statistically significant correlation between measurements MCA MoM-1 and fetal Hct-1 before the first IUIVT r = -0.622; p = 0.001 and MCA-MoM-3 and Hct-3 before the second IUIVT r = -0.381; p = 0.001, also as the significant correlation between the interval between both procedures (expressed in day) and measurement MCA-MoM-3, before the second IUIVT r = -0.284; p = 0.029.
  
  
  CONCLUSIONS
  The measurements MoM-MCA before every IUIVT can be useful for prediction of the best timing for the next IUIVT.
authors.forename: I
authors.initials: I
authors.lastname: Babović
authors.forename: S
authors.initials: S
authors.lastname: Plešinac
authors.forename: Z
authors.initials: Z
authors.lastname: Radojičić
authors.forename: O
authors.initials: O
authors.lastname: Antonović
authors.forename: R
authors.initials: R
authors.lastname: Sparić
authors.forename: D
authors.initials: D
authors.lastname: Plećaš
authors.forename: N
authors.initials: N
authors.lastname: Radunović
mesh_terms: D000740:Anemia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001805:Blood Transfusion, Intrauterine; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D005865:Gestational Age; D006400:Hematocrit; D006801:Humans; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011673:Pulsatile Flow; D012189:Retrospective Studies; D012203:Rh Isoimmunization; D055771:Serbia; D013599:Systole; D016216:Ultrasonography, Prenatal / Q000592:standards*