title: Ustekinumab for the treatment of Crohn's disease: can it find its niche?
abstract: Crohn's disease is an immune-mediated disease that results in panenteric chronic inflammation in genetically predisposed individuals exposed to an appropriate environment. The past two decades have witnessed the emergence of an important class of drugs known as anti-tumour necrosis factor (TNF) agents in the treatment of Crohn's disease. Unfortunately, the utility of these agents have been hampered by primary and secondary nonresponse in a significant proportion of patients. Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin (IL) 12 and 23, is a novel pharmacotherapy for this patient cohort that offers an out-of-class option. It is approved for use in psoriasis and psoriatic arthritis, and has now been evaluated in phase II trials for moderate-to-severe Crohn's disease. We here review the published literature and describe a potential clinical role for its use in this disease cohort.
authors.affiliation: Department of Gastroenterology, Christian Medical College, Vellore, India NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham University Hospitals NHS Trust and The University of Nottingham, Nottingham, UK.
authors.forename: Ebby G
authors.initials: EG
authors.lastname: Simon
authors.affiliation: Department of Medicine and IBD Clinic, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Subrata
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Medicine and IBD Clinic, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Marietta
authors.initials: M
authors.lastname: Iacucci
authors.affiliation: NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham University Hospitals NHS Trust and The University of Nottingham, Nottingham, UK.
authors.forename: Gordon W
authors.initials: GW
authors.lastname: Moran
keywords: Crohn’s disease; anti-TNF agents; ustekinumab