title: Integrated (18)F-fluorodeoxyglucose positron emission tomography magnetic resonance imaging ((18)F-FDG PET/MRI), a multimodality approach for comprehensive evaluation of dementia patients: A pictorial essay.
abstract: Dementia, caused by irreversible neurodegenerative disorders such as Alzheimer's disease or reversible non-degenerative conditions, is rapidly becoming one of the most alarming health problems in our aging society. This cognitive disorder associated with a multitude of clinical differentials with overlapping clinical, pathological, and imaging features is difficult to diagnose and treat, as it often presents late after significant neuronal damage has already occurred. Novel disease-modifying treatments being developed will have to be corroborated with innovative imaging biomarkers so that earlier reliable diagnosis can be made and treatment initiated upon. Along with new specific PET radiotracers, integrated PET/MRI with combined methodological advantage and simultaneously acquired structural-cum-functional information may help achieve this goal. The present pictorial essay details our experiences with PET/MRI in dementing disorders, along with reviewing recent advances and future scope.
authors.affiliation: PET SUITE, Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, New Delhi, India.
authors.forename: Amarnath
authors.initials: A
authors.lastname: Jena
authors.affiliation: PET SUITE, Department of Neurology, Indraprastha Apollo Hospitals, New Delhi, India.
authors.forename: Pushpendra Nath
authors.initials: PN
authors.lastname: Renjen
authors.affiliation: PET SUITE, Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, New Delhi, India.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Taneja
authors.affiliation: PET SUITE, Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, New Delhi, India.
authors.forename: Aashish
authors.initials: A
authors.lastname: Gambhir
authors.affiliation: PET SUITE, Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, New Delhi, India.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Negi
keywords: 18F-FDG; Alzheimer's disease; amyloid PET; dementia; integrated PET/MRI; vascular dementia