title: Microbial community profiling shows dysbiosis in the lesional skin of Vitiligo subjects.
abstract: Healthy human skin harbours a diverse array of microbes that comprise the skin microbiome. Commensal bacteria constitute an important component of resident microbiome and are intricately linked to skin health. Recent studies describe an association between altered skin microbial community and epidemiology of diseases, like psoriasis, atopic dermatitis etc. In this study, we compare the differences in bacterial community of lesional and non-lesional skin of vitiligo subjects. Our study reveals dysbiosis in the diversity of microbial community structure in lesional skin of vitiligo subjects. Although individual specific signature is dominant over the vitiligo-specific microbiota, a clear decrease in taxonomic richness and evenness can be noted in lesional patches. Investigation of community specific correlation networks reveals distinctive pattern of interactions between resident bacterial populations of the two sites (lesional and non-lesional). While Actinobacterial species constitute the central regulatory nodes (w.r.t. degree of interaction) in non-lesional skin, species belonging to Firmicutes dominate on lesional sites. We propose that the changes in taxonomic characteristics of vitiligo lesions, as revealed by our study, could play a crucial role in altering the maintenance and severity of disease. Future studies would elucidate mechanistic relevance of these microbial dynamics that can provide new avenues for therapeutic interventions.
authors.affiliation: CSIR-Institute of Genomics and Integrative Biology (IGIB), Mathura Road, New Delhi, India.|National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
authors.forename: Parul
authors.initials: P
authors.lastname: Ganju
authors.affiliation: Bio-Sciences R and D Division, TCS Innovation Labs, Tata Research Development and Design Centre, Tata Consultancy Services Ltd., 54-B Hadapsar Industrial Estate, Pune, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Nagpal
authors.affiliation: Bio-Sciences R and D Division, TCS Innovation Labs, Tata Research Development and Design Centre, Tata Consultancy Services Ltd., 54-B Hadapsar Industrial Estate, Pune, India.
authors.forename: M H
authors.initials: MH
authors.lastname: Mohammed
authors.affiliation: Bio-Sciences R and D Division, TCS Innovation Labs, Tata Research Development and Design Centre, Tata Consultancy Services Ltd., 54-B Hadapsar Industrial Estate, Pune, India.
authors.forename: P
authors.initials: P
authors.lastname: Nishal Kumar
authors.affiliation: CSIR Ayurgenomics Unit-TRISUTRA, CSIR- Institute of Genomics and Integrative Biology (IGIB), Mathura Road, New Delhi, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Pandey
authors.affiliation: CSIR-Institute of Genomics and Integrative Biology (IGIB), Mathura Road, New Delhi, India.
authors.forename: Vivek T
authors.initials: VT
authors.lastname: Natarajan
authors.affiliation: Bio-Sciences R and D Division, TCS Innovation Labs, Tata Research Development and Design Centre, Tata Consultancy Services Ltd., 54-B Hadapsar Industrial Estate, Pune, India.
authors.forename: Sharmila S
authors.initials: SS
authors.lastname: Mande
authors.affiliation: CSIR-Institute of Genomics and Integrative Biology (IGIB), Mathura Road, New Delhi, India.|National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.|Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.
authors.forename: Rajesh S
authors.initials: RS
authors.lastname: Gokhale
mesh_terms: D000328:Adult; D044822:Biodiversity; D064806:Dysbiosis; D005260:Female; D006801:Humans; D008297:Male; D054892:Metagenome; D056186:Metagenomics / Q000379:methods; D064307:Microbiota; D008875:Middle Aged; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012867:Skin / Q000382:microbiology* / Q000473:pathology; D014820:Vitiligo / Q000209:etiology*; D055815:Young Adult
chemical_list: D012336:RNA, Ribosomal, 16S