title: New insights into the regulation of innate immunity by caspase-8.
abstract: Caspase-8 is required for extrinsic apoptosis, but is also central for preventing a pro-inflammatory receptor interacting protein kinase (RIPK) 3-mixed lineage kinase domain-like (MLKL)-dependent cell death pathway termed necroptosis. Despite these critical cellular functions, the impact of capase-8 deletion in the myeloid cell lineage, which forms the basis for innate immune responses, has remained unclear. In a recent article in Arthritis Research & Therapy, Cuda et al. report that myeloid cell-restricted caspase-8 loss leads to a very mild RIPK3-dependent inflammatory phenotype. The presented results suggest that inflammation does not arise exclusively because of RIPK3-mediated necroptotic death but that, in the absence of caspase-8, RIPK1 and RIPK3 enhance microbiome-driven Toll-like receptor-induced pro-inflammatory cytokine production.
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Vitaliya
authors.initials: V
authors.lastname: Sagulenko
authors.affiliation: Walter and Eliza Hall Institute, Parkville, Melbourne, VIC, 3052, Australia.|Department of Medical Biology, The University of Melbourne, Parkville, Melbourne, VIC, 3050, Australia.
authors.forename: Kate E
authors.initials: KE
authors.lastname: Lawlor
authors.affiliation: Walter and Eliza Hall Institute, Parkville, Melbourne, VIC, 3052, Australia. vince@wehi.edu.au.|Department of Medical Biology, The University of Melbourne, Parkville, Melbourne, VIC, 3050, Australia. vince@wehi.edu.au.
authors.forename: James E
authors.initials: JE
authors.lastname: Vince
mesh_terms: D000818:Animals; D053181:Caspase 8 / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*
chemical_list: D053181:Caspase 8