title: [Impacts of ABO incompatibility on early outcome after single unit unrelated cord blood transplantation: a retrospective single center experience].
abstract: OBJECTIVE
  To retrospectively study the impacts of ABO incompatibility on early outcome after single unit unrelated cord blood transplantation（UCBT）, such as cumulative incidence of engraftment, incidence of acute graft- versus- host disease （aGVHD） and 180- day transplant- related mortality（TRM）.
  
  
  METHODS
  208 patients underwent single unit UCBT from April 2008 to October 2014 were analyzed, included 99 ABO- identical, 60 minor, 38 major and 11 bidirectional ABO- incompatible recipients. All the patients received intensified myeloablative conditioning, and a combination of cyclosporine A and mycophenolate mofetil was given for GVHD prophylaxis.
  
  
  RESULTS
  Cumulative incidences of neutrophil engraftment, platelet recovery, erythroid lineage reconstitution, Ⅱ-Ⅳ aGVHD, Ⅲ-Ⅳ aGVHD and 180- day TRM showed no significant difference among the patients receiving ABOidentical, minor, major, and bidirectional UCBT（all P>0.05, respectively）. What's more, none of the patients developed pure red- cell aplasia（PRCA）after UCBT. Group A donor and a group O recipient patients didn't appeared to influence the clinical results when compared with others（all P>0.05, respectively）.
  
  
  CONCLUSIONS
  Patients receive ABO- incompatible UCBT may not develop PRCA. The presence of ABO- incompatibility did not influence the hematopoietic reconstitution, the incidence of aGVHD and 180-day TRM in this cohort. There is not support for the need to regard ABO-compatibility as an UCB-graft selection criterion.
authors.affiliation: Department of Hematology, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Hematology, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Sun
authors.affiliation: Department of Hematology, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Yao
authors.affiliation: Department of Hematology, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Hematology, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Baolin
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Hematology, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Changcheng
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Department of Hematology, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Huilan
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Hematology, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Zimin
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000017:ABO Blood-Group System; D001787:Blood Group Incompatibility; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects; D016572:Cyclosporine / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D012010:Red-Cell Aplasia, Pure / Q000150:complications; D012189:Retrospective Studies; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D000017:ABO Blood-Group System; D016572:Cyclosporine; D009173:Mycophenolic Acid