title: Enhanced glucose tolerance by intravascularly administered piceatannol in freely moving healthy rats.
abstract: Piceatannol is a phytochemical in the seeds of passion fruit that has a hypoglycemic effect when orally administered. To elucidate the contribution of intact and metabolites of piceatannol after gastro-intestinal absorption to hypoglycemic effect, we examined the influence of piceatannol and isorhapontigenin on blood glucose concentrations during fasting and glucose tolerance tests by administering them intravascularly to freely moving healthy rats. We found that intravascularly administered piceatannol reduced the blood glucose concentrations during both fasting and glucose tolerance tests, but isorhapontigenin did not during either of them. Furthermore, we found that piceatannol increased the insulinogenic index during glucose tolerance tests and that piceatannol had no influence on insulin sensitivity by performing hyperinsulinemic euglycemic clamping tests. These results suggest that piceatannol orally intaken may enhance glucose tolerance by the effect of intact piceatannol through enhanced early-phase secretion of insulin. Therefore, oral intake of piceatannol might contribute to proper control of postprandial glycemic excursions in healthy subjects.
authors.affiliation: Health Science Research Center, Morinaga & Co., Ltd., 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Oritani
authors.affiliation: Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan. Electronic address: okitsu@iis.u-tokyo.ac.jp.
authors.forename: Teru
authors.initials: T
authors.lastname: Okitsu
authors.affiliation: Health Science Research Center, Morinaga & Co., Ltd., 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan.
authors.forename: Eisaku
authors.initials: E
authors.lastname: Nishimura
authors.affiliation: Health Science Research Center, Morinaga & Co., Ltd., 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sai
authors.affiliation: Health Science Research Center, Morinaga & Co., Ltd., 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Ito
authors.affiliation: Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan. Electronic address: takeuchi@iis.u-tokyo.ac.jp.
authors.forename: Shoji
authors.initials: S
authors.lastname: Takeuchi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005215:Fasting / Q000097:blood*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013267:Stilbenes / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene
keywords: Freely moving rat; Glucose tolerance; Insulin; Piceatannol