title: Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes.
abstract: In this work, we present an infrared plasmonic biosensor for chemical-specific detection and monitoring of biomimetic lipid membranes in a label-free and real-time fashion. Lipid membranes constitute the primary biological interface mediating cell signaling and interaction with drugs and pathogens. By exploiting the plasmonic field enhancement in the vicinity of engineered and surface-modified nanoantennas, the proposed biosensor is able to capture the vibrational fingerprints of lipid molecules and monitor in real time the formation kinetics of planar biomimetic membranes in aqueous environments. Furthermore, we show that this plasmonic biosensor features high-field enhancement extending over tens of nanometers away from the surface, matching the size of typical bioassays while preserving high sensitivity.
authors.affiliation: Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne 1015, Switzerland.
authors.forename: Odeta
authors.initials: O
authors.lastname: Limaj
authors.affiliation: Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne 1015, Switzerland.
authors.forename: Dordaneh
authors.initials: D
authors.lastname: Etezadi
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota , Minneapolis, Minnesota 55455, United States.
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Wittenberg
authors.affiliation: Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne 1015, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rodrigo
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota , Minneapolis, Minnesota 55455, United States.
authors.forename: Daehan
authors.initials: D
authors.lastname: Yoo
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota , Minneapolis, Minnesota 55455, United States.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Oh
authors.affiliation: Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne 1015, Switzerland.
authors.forename: Hatice
authors.initials: H
authors.lastname: Altug
mesh_terms: D015374:Biosensing Techniques; D007700:Kinetics; D008563:Membrane Lipids / Q000737:chemistry / Q000302:isolation & purification*; D049329:Nanostructures / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D020349:Surface Plasmon Resonance; D014867:Water / Q000737:chemistry
chemical_list: D008563:Membrane Lipids; D014867:Water
keywords: Surface-enhanced infrared absorption; label-free biosensor; lipid membrane; near-field decay; plasmonics; real-time kinetics