title: Highly controlled coating of strontium-doped hydroxyapatite on electrospun poly(ɛ-caprolactone) fibers.
abstract: Electrospun fibers show great potential as scaffolds for bone tissue engineering due to their architectural biomimicry to the extracellular matrix (ECM). Cation substitution of strontium for calcium in hydroxyapatite (HAp) positively influences the mechanism of bone remodeling including enhancing bone regeneration and reducing bone resorption. The objective of this study was to attach strontium-doped HAp (SrHAp) to electrospun poly(ɛ-caprolactone) (PCL) fibers for creation of novel composite scaffolds that can not only mimic the architecture and composition of ECM but also affect bone remodeling favorably. We demonstrated for the first time the highly controlled SrHAp coatings on electrospun PCL fibers. We showed the reproducible manufacturing of composite fiber scaffolds with controllable thickness, composition, and morphology of SrHAp coatings. We further showed that the released strontium and calcium cations from coatings could reach effective concentrations within 1 day and endure more than 28 days. Additionally, the Young's modulus of the SrHAp-coated PCL fibers was up to around six times higher than that of raw fibers dependent on the coating thickness and composition. Together, this novel class of composite fiber scaffolds may hold great promise for bone regeneration. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 753-763, 2017.
authors.affiliation: Department of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, 68198.
authors.forename: Lin
authors.initials: L
authors.lastname: Weng
authors.affiliation: Department of Orthopedic Surgery, University of Nebraska Medical Center, Omaha, Nebraska, 68198.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Teusink
authors.affiliation: Department of Orthopedic Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, 25701.
authors.forename: Franklin D
authors.initials: FD
authors.lastname: Shuler
authors.affiliation: Department of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, 68198.
authors.forename: Vivi
authors.initials: V
authors.lastname: Parecki
authors.affiliation: Department of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, 68198.
authors.forename: Jingwei
authors.initials: J
authors.lastname: Xie
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D055119:Elastic Modulus; D005109:Extracellular Matrix / Q000737:chemistry*; D006801:Humans; D011091:Polyesters / Q000737:chemistry*; D013324:Strontium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D011091:Polyesters; C016240:polycaprolactone; D017886:Durapatite; D013324:Strontium
keywords: coating; electrospinning; hydroxyapatite; poly(ɛ-caprolactone) fibers; strontium