title: Revisiting supersaturation as a factor determining amyloid fibrillation.
abstract: Amyloid fibrils involved in various diseases are formed by a nucleation-growth mechanism, similar to the crystallization of solutes from solution. Solubility and supersaturation are two of the most important factors determining crystallization of solutes. Moreover, crystallization competes with glass formation in which solutes collapse into amorphous aggregates. Recent studies on the formation of amyloid fibrils and amorphous aggregates indicate that the partition between distinct types of aggregates can be rationally explained by a kinetic and thermodynamic competition between them. Understanding the role of supersaturation in determining aggregation-based phase transitions of denatured proteins provides an important complementary point of view to structural studies of protein aggregates.
authors.affiliation: Institute for Protein Research, Osaka University, Yamadaoka 3-2, Suita, Osaka 565-0871, Japan.
authors.forename: Masatomo
authors.initials: M
authors.lastname: So
authors.affiliation: Institute for Protein Research, Osaka University, Yamadaoka 3-2, Suita, Osaka 565-0871, Japan; Research School of Chemistry, Australian National University, Acton, ACT 2601, Australia.
authors.forename: Damien
authors.initials: D
authors.lastname: Hall
authors.affiliation: Institute for Protein Research, Osaka University, Yamadaoka 3-2, Suita, Osaka 565-0871, Japan. Electronic address: gtyj8126@protein.osaka-u.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Goto
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism; D000682:Amyloid / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism; D066329:Protein Aggregates; D066263:Protein Aggregation, Pathological; D011485:Protein Binding; D055503:Protein Multimerization; D020543:Proteome
chemical_list: D000682:Amyloid; D015415:Biomarkers; D066329:Protein Aggregates; D020543:Proteome