title: Current understanding of the functional roles of aberrantly expressed microRNAs in esophageal cancer.
abstract: The incidence of esophageal cancer is rising, mostly because the increasing incidence of esophageal adenocarcinoma in Western countries. Despite improvements in diagnosis and treatment, the overall 5-year survival rates remain low. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the expression of target genes. Recently, disease specific miRNAs have been identified, which act as tumor suppressors or oncogenes. In this review, we will summarize the current knowledge about the function of aberrantly expressed miRNAs in esophageal cancer. We selected 5 miRNAs (miRNA-21, -143, -145, -196a and let-7) based on the available literature, and described their potential role in regulating pathways that are deregulated in esophageal cancer. Finally we will highlight the current achievements of using and targeting miRNAs. Because these miRNAs likely have important regulatory roles in cancer development, they open a therapeutic window for new treatment modalities.
authors.affiliation: Christine Kestens, Peter D Siersema, Jantine WPM van Baal, Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.
authors.forename: Christine
authors.initials: C
authors.lastname: Kestens
authors.affiliation: Christine Kestens, Peter D Siersema, Jantine WPM van Baal, Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Siersema
authors.affiliation: Christine Kestens, Peter D Siersema, Jantine WPM van Baal, Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.
authors.forename: Jantine W P M
authors.initials: JW
authors.lastname: van Baal
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D009857:Oncogenes; D012334:RNA, Neoplasm / Q000235:genetics* / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D012334:RNA, Neoplasm
keywords: Esophageal adenocarcinoma; Esophageal cancer; Esophageal squamous cell carcinoma; MicroRNAs; Target genes