title: Overexpression of HOXC8 is Associated With Poor Prognosis in Epithelial Ovarian Cancer.
abstract: Homeobox C8 (HOXC8) is a transcription factor that has been reported as a potential driver oncogene in several tumors and involved in the regulation of many cancer-related proteins. In this study, we investigated the expression and role of HOXC8 in ovarian cancer. Western blot and immunohistochemistry analyses were performed to detect the expression of HOXC8. Kaplan-Meier curve showed that high expression of HOXC8 was related to poor prognosis of patients with epithelial ovarian cancer (EOC). Starvation and refeeding assay were used to assess cell cycle, suggesting that HOXC8 played a critical role in EOC cell proliferation. HOXC8 depletion by small interfering RNA inhibited cell proliferation, migration, and induced apoptosis in EOC cells. Moreover, HOXC8 knockdown increased the expression of ZAC1. Owing to the overexpression of HOXC8, our findings implied that HOXC8 is involved in the progression of EOC and could be a potential therapeutical approach of EOC.
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Pathology, Nantong University Cancer Hospital, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Su
authors.affiliation: Department of Pathology, Nantong University Cancer Hospital, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Yingze
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Pathology, Nantong University Cancer Hospital, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Shuyun
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Pathology, Nantong University Cancer Hospital, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Song
authors.initials: S
authors.lastname: He
authors.affiliation: The Center for Reproductive Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, Nantong University Cancer Hospital, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Fulin
authors.initials: F
authors.lastname: Qiang
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Shuyang
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China.
authors.forename: Mengting
authors.initials: M
authors.lastname: Shao
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China maoguoxinnt@163.com.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Mao
mesh_terms: D017209:Apoptosis; D000077216:Carcinoma, Ovarian Epithelial; D002453:Cell Cycle; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis
chemical_list: C489815:HOXC8 protein, human; D018398:Homeodomain Proteins
keywords: HOXC8; apoptosis; migration; ovarian cancer; proliferation