title: Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer.
abstract: BACKGROUND
  Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, accounts for 3% of newly diagnosed cases of colorectal cancer. While a partial or subtotal colectomy is indicated for early stage disease, there is a paucity of data addressing locally advanced disease involving the foregut.
  
  
  METHODS
  We report two patients with hereditary nonpolyposis colorectal cancer presenting with locally advanced colon cancer surgically managed by pancreaticoduodenectomy with en bloc partial colectomy and a review of the literature.
  
  
  CONCLUSIONS
  Locally advanced colorectal cancer in HNPCC is a rare clinical entity that requires special surgical consideration. Multidisciplinary treatment, including multi-visceral resection, offers the best long-term outcome.
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA. R.Zhu@yale.edu.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Zhu
authors.affiliation: Department of Surgery, Yale University School of Medicine, New Haven, CT, USA. Gabriella.Grisotti@yale.edu.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Grisotti
authors.affiliation: Department of Surgery, Section of Surgical Oncology, Yale University School of Medicine, PO BOX 208062, New Haven, CT, USA. Ronald.Salem@yale.edu.
authors.forename: Ronald R
authors.initials: RR
authors.lastname: Salem
authors.affiliation: Department of Surgery, Section of Surgical Oncology, Yale University School of Medicine, PO BOX 208062, New Haven, CT, USA. Sajid.Khan@yale.edu.
authors.forename: Sajid A
authors.initials: SA
authors.lastname: Khan
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D003082:Colectomy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016577:Pancreaticoduodenectomy