title: Rapid Extensive Recurrence of Triple Negative Breast Cancer: Are Both Therapy and Cancer Biology the Culprit?
abstract: Triple negative breast cancer (TNBC) comprises 17-20% of all breast cancers and is one of the most common breast cancers. The lack of therapy and failure of existing therapy has been a challenge for clinicians. Doxorubicin (DOX) is the first-line therapy, however, it has significant limitations. Rapid extensive recurrence with metastasis in any cancer has been a challenge for surgeons and medical oncologists. The challenge can be due to failure of therapy, drug resistance, or epigenetic changes. Here, we are discussing a stage I breast cancer patient, operated and treated with appropriate chemotherapy with complete response, which recurred in less than 8 months and metastasized to bone, liver and other organs. We are also presenting lab data of the IL-6 secretions on exposure to DOX in one of the most commonly used TNBC cell lines MDA-MB-231. Breast cancer cell line MDA-MB-231 upon exposure to DOX shows an increase in IL-6 levels more than the already elevated IL-6 levels. This might be a reason for early recurrence. We concluded that patients with TNBC might benefit from a standard DOX treatment regimen with an inflammation-blocking agent.
authors.affiliation: 61391 ODE Surgery, Department of Surgery, Texas Tech University Health Sciences Center, 3601 Fourth Street, Lubbock, TX 79430, USA; These authors contributed equally to this paper.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Vyas
authors.affiliation: Michigan State University, College of Human Medicine, 1200 East Michigan Avenue, Suite 655, East Lansing, MI 48824, USA.
authors.forename: Kaivalya
authors.initials: K
authors.lastname: Deshpande
authors.affiliation: Michigan State University, College of Human Medicine, 1200 East Michigan Avenue, Suite 655, East Lansing, MI 48824, USA.
authors.forename: Lakshmishankar
authors.initials: L
authors.lastname: Chaturvedi
authors.affiliation: Michigan State University, College of Human Medicine, 1200 East Michigan Avenue, Suite 655, East Lansing, MI 48824, USA; These authors contributed equally to this paper.
authors.forename: Laput
authors.initials: L
authors.lastname: Gieric
authors.affiliation: Michigan State University, College of Human Medicine, 1200 East Michigan Avenue, Suite 655, East Lansing, MI 48824, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Ching
keywords: Cancer; Doxorubicin; IL-6; Inflammation; Metastasis