title: New neo-clerodane diterpenoids from Scutellaria strigillosa with cytotoxic activities.
abstract: Two new neo-clerodane diterpenoids, named scutestrigillosins D and E (1 and 2), were isolated from the whole plant Scutellaria strigillosa. Their structures were established on the basis of detailed physical data analyses. In vitro, two new compounds exhibited cytotoxic activities against four tumor cell lines (HONE-1, P-388, MCF7, and HT29), and gave IC50 values in the range of 3.4-8.9 μΜ.
authors.affiliation: a School of Pharmaceutical Science , Yantai University , Yantai 264005 , China.
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Dai
authors.affiliation: a School of Pharmaceutical Science , Yantai University , Yantai 264005 , China.
authors.forename: Kai
authors.initials: K
authors.lastname: Xiao
authors.affiliation: a School of Pharmaceutical Science , Yantai University , Yantai 264005 , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a School of Pharmaceutical Science , Yantai University , Yantai 264005 , China.
authors.forename: Qing-Tong
authors.initials: QT
authors.lastname: Han
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry; D031363:Scutellaria / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C000613497:scutestrigillosin D; C000613498:scutestrigillosin E
keywords: Labiatae; Scutellaria strigillosa; cytotoxic activity; neo-clerodane diterpenoid; scutestrigillosins D–E