title: Carbon nanotubes implanted manganese-based MOFs for simultaneous detection of biomolecules in body fluids.
abstract: Metal-organic frameworks (MOFs) have recently attracted much interest in electrochemical fields due to their controlled porosity, large internal surface area, and countless structural topologies. However, the direct application of single component MOFs is limited since they also exhibit poor electronic conductivity, low mechanical stability, and inferior electrocatalytic ability. To overcome these problems, we implanted multi-walled carbon nanotubes (MWCNTs) into manganese-based metal-organic frameworks (Mn-BDC) using a one-step solvothermal method and found that the introduction of MWCNTs can initiate the splitting of bulky Mn-BDC into thin layers. This splitting is highly significant in that it enhances the electronic conductivity and electrocatalytic ability of Mn-BDC. The constructed Mn-BDC@MWCNT composites were utilized as an electrode modifying material in the fabrication of an electrochemical sensor and then were used successfully for the determination of biomolecules in human body fluid. The sensor displayed successful detection performance with wide linear detection ranges (0.1-1150, 0.01-500, and 0.02-1100 μM for AA, DA and UA, respectively) and low limits of detection (0.01, 0.002, and 0.005 μM for AA, DA and UA, respectively); thus, this preliminary study presents an electrochemical biosensor constructed with a novel electrode modifying material that exhibits superior potential for the practical detection of AA, DA and UA in urine samples.
authors.affiliation: Institute for Clean Energy & Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, P.R. China. baoshj@swu.edu.cn.
authors.forename: Min-Qiang
authors.initials: MQ
authors.lastname: Wang
authors.affiliation: Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.
authors.forename: Cui
authors.initials: C
authors.lastname: Ye
authors.affiliation: Institute for Clean Energy & Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, P.R. China. baoshj@swu.edu.cn.
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Bao
authors.affiliation: Institute for Clean Energy & Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, P.R. China. baoshj@swu.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute for Clean Energy & Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, P.R. China. baoshj@swu.edu.cn.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Yu
authors.affiliation: Institute for Clean Energy & Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, P.R. China. baoshj@swu.edu.cn.
authors.forename: Mao-wen
authors.initials: MW
authors.lastname: Xu
mesh_terms: D001205:Ascorbic Acid / Q000652:urine*; D004298:Dopamine / Q000652:urine*; D004563:Electrochemistry; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D008345:Manganese / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors; D014527:Uric Acid / Q000652:urine*; D016482:Urinalysis / Q000379:methods*
chemical_list: D037742:Nanotubes, Carbon; D009942:Organometallic Compounds; D014527:Uric Acid; D008345:Manganese; D001205:Ascorbic Acid; D004298:Dopamine