title: [Supramolecular Agents for Theranostics].
abstract: This mini-review summarizes recent data obtained in the process of creation of a versatile module platform suitable for construction of supramolecular theranostic agents. As an example, we consider multifunctional hybrid agents for imaging and elimination of cancer cells. The use of an adapter protein system barnase:barstar for producing targeted multifunctional hybrid structures on the basis of highly specific peptides and mini-antibodies as addressing modules and recombinant proteins and/or nanoparticles of different nature (quantum dots, nanogold, magnetic nanoparticles, nanodiamonds, upconverting nanophosphores, polymer nanoparticles) as agents visualizing and damaging cancer cells is described. New perspectives for creation of selective and highly effective compounds for theranostics and personified medicine are contemplated.
authors.forename: S M
authors.initials: SM
authors.lastname: Deyev
authors.forename: E N
authors.initials: EN
authors.lastname: Lebedenko
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001698:Biomedical Engineering; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D000922:Immunotoxins / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D011994:Recombinant Proteins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012260:Ribonucleases / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D001426:Bacterial Proteins; D004337:Drug Carriers; D000922:Immunotoxins; D011994:Recombinant Proteins; C057438:barstar protein, Bacillus amyloliquefaciens; D012260:Ribonucleases; C019760:Bacillus amyloliquefaciens ribonuclease