title: Maternal Nutrition and Glycaemic Index during Pregnancy Impacts on Offspring Adiposity at 6 Months of Age--Analysis from the ROLO Randomised Controlled Trial.
abstract: Childhood obesity is associated with increased risk of adult obesity and metabolic disease. Diet and lifestyle in pregnancy influence fetal programming; however the influence of specific dietary components, including low glycaemic index (GI), remains complex. We examined the effect of a maternal low GI dietary intervention on offspring adiposity at 6 months and explored the association between diet and lifestyle factors in pregnancy and infant body composition at 6 months. 280 6-month old infant and mother pairs from the control (n = 142) and intervention group (n = 138), who received low GI dietary advice in pregnancy, in the ROLO study were analysed. Questionnaires (food diaries and lifestyle) were completed during pregnancy, followed by maternal lifestyle and infant feeding questionnaires at 6 months postpartum. Maternal anthropometry was measured throughout pregnancy and at 6 months post-delivery, along with infant anthropometry. No difference was found in 6 months infant adiposity between control and intervention groups. Maternal trimester three GI, trimester two saturated fats and trimester one and three sodium intake were positively associated with offspring adiposity, while trimester two and three vitamin C intake was negatively associated. In conclusion associations were observed between maternal dietary intake and GI during pregnancy and offspring adiposity at 6 months of age.
authors.affiliation: UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin 2, Ireland. maryhoran21@hotmail.com.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Horan
authors.affiliation: UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin 2, Ireland. cmcgowa@gmail.com.
authors.forename: Ciara A
authors.initials: CA
authors.lastname: McGowan
authors.affiliation: School of Agriculture &amp; Food Science, University College Dublin, Dublin 4, Ireland. Eileen.gibney@ucd.ie.
authors.forename: Eileen R
authors.initials: ER
authors.lastname: Gibney
authors.affiliation: UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin 2, Ireland. jabyrne@nmh.ie.
authors.forename: Jacinta
authors.initials: J
authors.lastname: Byrne
authors.affiliation: UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin 2, Ireland. donnelly.jean@gmail.com.
authors.forename: Jean M
authors.initials: JM
authors.lastname: Donnelly
authors.affiliation: UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin 2, Ireland. fionnuala.mcauliffe@ucd.ie.
authors.forename: Fionnuala M
authors.initials: FM
authors.lastname: McAuliffe
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity; D000328:Adult; D001205:Ascorbic Acid / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004032:Diet; D004041:Dietary Fats / Q000009:adverse effects; D005260:Female; D047109:Fetal Development; D038321:Glycemic Index; D006801:Humans; D007223:Infant; D008297:Male; D063766:Pediatric Obesity / Q000209:etiology* / Q000517:prevention & control; D049590:Postpartum Period; D011247:Pregnancy; D011264:Pregnancy Trimesters; D039401:Prenatal Nutritional Physiological Phenomena; D017673:Sodium Chloride, Dietary / Q000009:adverse effects; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D017673:Sodium Chloride, Dietary; D001205:Ascorbic Acid
keywords: childhood obesity; fetal programming; glycaemic index; maternal nutrition; offspring adiposity