title: Aqueous phase preparation of ultrasmall MoSe2 nanodots for efficient photothermal therapy of cancer cells.
abstract: Photothermal therapy (PTT) is a promising cancer treatment with both high effectiveness and fewer side effects. However, an ideal PTT agent not only needs strong absorption of near-infrared (NIR) light and high photothermal conversion efficiency, but also needs good biocompatibility, stability, and small size, which makes the design and preparation of a novel PTT agent a great challenge. In this work, we developed an ultrasonication-assisted liquid exfoliation method for the direct preparation of ultrasmall (2-3 nm) MoSe2 nanodots (NDs) in aqueous solution and demonstrated their superior properties as a PTT agent. The as-prepared MoSe2 NDs have strong absorption of NIR light and high photothermal conversion efficiency of about 46.5%. In vitro cellular experiments demonstrate that MoSe2 NDs have negligible cytotoxicity and can efficiently kill HeLa cells (human cervical cell line) under NIR laser (785 nm) irradiation.
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
authors.forename: Lihui
authors.initials: L
authors.lastname: Yuwen
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
authors.forename: Jingyang
authors.initials: J
authors.lastname: Shan
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Luo
authors.affiliation: School of Geography and Biological Information, Nanjing University of Posts & Telecommunications, Nanjing 210023, China.
authors.forename: Lixing
authors.initials: L
authors.lastname: Weng
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Teng
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
authors.forename: Lianhui
authors.initials: L
authors.lastname: Wang
mesh_terms: D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D046529:Microscopy, Electron, Transmission; D008982:Molybdenum / Q000737:chemistry* / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000628:therapy; D056951:Photoelectron Spectroscopy; D010789:Phototherapy; D011108:Polymers / Q000737:chemistry; D012643:Selenium / Q000737:chemistry* / Q000494:pharmacology; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D011108:Polymers; D014867:Water; D008982:Molybdenum; D012643:Selenium