title: Simulation of Viral Hepatitis E in Marmosets.
abstract: We developed a model of hepatitis E virus infection in common marmosets (Callithrix jacchus) and determined optimal route of infection, duration, clinical and virological characteristics of infection in laboratory animals. Using this model, we demonstrated that replication of hepatitis E virus primarily occurs in the liver, while virus replication presumed to take place in the intestine was not confirmed in this experiment.
authors.affiliation: M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow, Russia. karen-kyuregyan@yandex.ru.
authors.forename: K K
authors.initials: KK
authors.lastname: Kyuregyan
authors.affiliation: M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: V F
authors.initials: VF
authors.lastname: Poleshchuk
authors.affiliation: M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Gordeichuk
authors.affiliation: M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Gulyaeva
authors.affiliation: M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Isaeva
authors.affiliation: M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Morozov
authors.affiliation: M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: M I
authors.initials: MI
authors.lastname: Mikhailov
mesh_terms: D000818:Animals; D002144:Callithrix; D016751:Hepatitis E / Q000821:virology*; D007422:Intestines / Q000821:virology; D008099:Liver / Q000821:virology; D014779:Virus Replication / Q000502:physiology
keywords: experimental infection; hepatitis E; hepatitis E virus; marmosets; virus replication