title: Responses of antioxidant defense system to polyfluorinated dibenzo-p-dioxins (PFDDs) exposure in liver of freshwater fish Carassius auratus.
abstract: In this study, we evaluated the toxicity of ten polyfluorinated dibenzo-p-dioxins (PFDDs) congeners to freshwater fish Carassius auratus, by determining the antioxidative responses and lipid peroxidation in the liver after the fish were injected with two different concentrations (10 and 100 µmol/kg) of individual PFDDs for 3 and 14 days. The results showed that oxidative stress was obviously induced in some PFDDs-treated groups, as implied by the significantly inhibited antioxidants levels (superoxide dismutase, catalase, reduced glutathione, and glutathione S-transferase) and elevated malondialdehyde content. In addition, the oxidative stress inducing ability was variable for different PFDDs congeners, which was related with the substitution number and position of fluorine atom. Based on the calculated integrated biomarker response (IBR) values, the toxicity was ranked as 2,3,7,8-FDD>Octa-FDD>1,2,3,4,7-FDD>1,3,6,8-FDD>1,2,3,4,6,7-FDD>1,2,6,7-FDD>1,2,7-FDD>DD>2,7-FDD>2-FDD. This study can enhance the general understanding of the PFDDs induced oxidative stress in aquatic organisms.
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of Environment, Nanjing University, Jiangsu Nanjing 210023, PR China.
authors.forename: Chenguang
authors.initials: C
authors.lastname: Li
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of Environment, Nanjing University, Jiangsu Nanjing 210023, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Qin
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of Environment, Nanjing University, Jiangsu Nanjing 210023, PR China.
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Qu
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of Environment, Nanjing University, Jiangsu Nanjing 210023, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of Environment, Nanjing University, Jiangsu Nanjing 210023, PR China. Electronic address: wangzun315cn@163.com.
authors.forename: Zunyao
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004147:Dioxins / Q000737:chemistry / Q000633:toxicity*; D005618:Fresh Water; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006054:Goldfish / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D004147:Dioxins; D014874:Water Pollutants, Chemical; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione; C020887:dibenzo(1,4)dioxin
keywords: Carassius auratus; Integrated biomarker response; Oxidative stress; Polyfluorinated dibenzo-p-dioxins; Toxicity order