title: The LAST Project and the diagnostic bottom line.
abstract: The LAST Project's consensus recommendations for terminology and biomarker use to improve the accuracy and reproducibility of histopathological diagnoses for HPV-associated squamous intraepithelial lesions of the lower anogenital tract are reviewed.
authors.affiliation: Departments of Pathology and Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Darragh
mesh_terms: D001003:Anal Canal / Q000473:pathology; D001005:Anus Neoplasms / Q000145:classification* / Q000473:pathology; D015415:Biomarkers; D002584:Cervix Uteri / Q000166:cytology / Q000473:pathology; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004801:Eosine Yellowish-(YS); D005260:Female; D005456:Fluorescent Dyes; D006416:Hematoxylin; D006801:Humans; D009363:Neoplasm Proteins / Q000276:immunology; D030361:Papillomavirus Infections / Q000145:classification* / Q000473:pathology; D015203:Reproducibility of Results; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000145:classification* / Q000473:pathology; D009626:Terminology as Topic
chemical_list: D015415:Biomarkers; C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005456:Fluorescent Dyes; D009363:Neoplasm Proteins; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin
keywords: HPV; p16; squamous intraepithelial lesions; terminology