title: Evaluation of periodontitis treatment effects on carotid intima-media thickness and expression of laboratory markers related to atherosclerosis.
abstract: The objective of this research was to evaluate the treatment of periodontal disease and its effects on carotid intima-media thickness (CIMT) and expression of laboratory markers related to atherosclerosis. Twenty-three healthy patients (group 1) and 21 patients with moderate to severe periodontitis (group 2) underwent evaluation of clinical periodontal parameters. The patients were submitted to CIMT measurements and laboratory evaluations at the start of the study (0 months), 6 months, and 12 months. All patients received oral hygiene instruction; patients in group 2 also underwent supragingival and subgingival scaling and root planing. A statistically significant improvement in clinical periodontal parameters occurred in both groups (P < 0.05). Improvements were more evident between the first and second evaluations and were greater in group 2. Both groups experienced a statistically significant decrease in CIMT in the first 6 months (P < 0.05). Treatments--oral hygiene instruction in group 1 and instruction plus mechanical periodontal instrumentation in group 2--were effective in improving clinical periodontal parameters of both groups and promoting reduction in CIMT at 6 months.
authors.forename: Jeferson Freitas
authors.initials: JF
authors.lastname: Toregeani
authors.forename: Carlos Augusto
authors.initials: CA
authors.lastname: Nassar
authors.forename: Patrícia Oehlmeyer
authors.initials: PO
authors.lastname: Nassar
authors.forename: Krischina Mendes
authors.initials: KM
authors.lastname: Toregeani
authors.forename: Geyssi Karolyne
authors.initials: GK
authors.lastname: Gonzatto
authors.forename: Rafael
authors.initials: R
authors.lastname: Vendrame
authors.forename: Jussimar Scheffer
authors.initials: JS
authors.lastname: Castilhos
authors.forename: Larissa Sokol
authors.initials: LS
authors.lastname: Rotta
authors.forename: Andréia Carpenedo
authors.initials: AC
authors.lastname: Reinheimer
authors.forename: Anelise
authors.initials: A
authors.lastname: Longoni
authors.forename: Mariana Waterkemper Andrade
authors.initials: MW
authors.lastname: Barcella
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood* / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D012534:Dental Scaling; D006801:Humans; D010518:Periodontitis / Q000150:complications / Q000628:therapy*; D013997:Time Factors; D014280:Triglycerides
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D002784:Cholesterol
keywords: atherosclerosis; carotid intima-media thickness; periodontal treatment; periodontitis