title: Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health.
abstract: Osteoarthritis (OA) is a common form of arthritis in humans. It has long been regarded as a non-inflammatory disease, but a degree of inflammation is now recognized as being a vital inducer of subpopulation of OA. Besides inflammation, the establishment and development of OA are associated with alterations in metabolism and profiles of amino acids (AA), including glutamate- and arginine-family AA as well as their related metabolites (e.g., creatinine, hydroxyproline, γ-aminobutyrate, dimethylarginines and homoarginine). Functional AA (e.g., glutamine, arginine, glutamate, glycine, proline, and tryptophan) have various benefits (i.e., anti-inflammation and anti-oxidation) in treatment of inflammation-associated diseases, including OA. Thus, these AA have potential as immunomodulatory nutrients for patients with inflammation-induced OA.
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zeng
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
authors.forename: Zhenhan
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, 410125, Hunan, China.
authors.forename: Wenkai
authors.initials: W
authors.lastname: Ren
authors.affiliation: Department of Animal Science, Texas A&M University, 2471 TAMU, College Station, TX, 77843-2471, USA.
authors.forename: Guoyao
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China. lgh9640@sina.cn.
authors.forename: Guanghua
authors.initials: G
authors.lastname: Lei
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives / Q000276:immunology / Q000378:metabolism; D003404:Creatinine / Q000276:immunology / Q000378:metabolism; D018698:Glutamic Acid / Q000276:immunology / Q000378:metabolism; D005973:Glutamine / Q000276:immunology / Q000378:metabolism; D006709:Homoarginine / Q000276:immunology / Q000378:metabolism; D006801:Humans; D006909:Hydroxyproline / Q000276:immunology / Q000378:metabolism; D007155:Immunologic Factors / Q000378:metabolism; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009751:Nutritional Requirements / Q000276:immunology*; D009752:Nutritional Status / Q000276:immunology*; D010003:Osteoarthritis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011392:Proline / Q000276:immunology / Q000378:metabolism; D014364:Tryptophan / Q000276:immunology / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000276:immunology / Q000378:metabolism
chemical_list: D007155:Immunologic Factors; C487735:dimethylarginine; D005973:Glutamine; D006709:Homoarginine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D014364:Tryptophan; D001120:Arginine; D011392:Proline; D003404:Creatinine; D006909:Hydroxyproline
keywords: Arginine; Glutamate; Glutamine; Inflammation; Osteoarthritis