title: Elevated glycated hemoglobin levels impair blood pressure in children and adolescents with type 1 diabetes mellitus.
abstract: BACKGROUND
  Deregulation of glycemic and glycated hemoglobin (HbA1) levels accelerate the progression of cardiovascular complications in type 1 diabetes mellitus (T1DM). The aim of this study was to investigate the association between HbA1 and changes in blood pressure of children and adolescents with T1DM.
  
  
  METHODS
  A total of 60 children and adolescents were recruited and allocated into two groups (prehypertension and control group). Blood pressure and HbA1 were measured by the oscillometric method and high-performance liquid chromatography, respectively.
  
  
  RESULTS
  The prehypertensive group had (P < 0.05) higher disease duration, body weight, Z score for body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and a higher HbA1 when compared with the control children and adolescents. Multiple regression to predict alterations in DBP from HbA1 adjusted for age, disease duration, and body mass index demonstrated a positive relationship with DBP (P < 0.05). A 1 % increase in HbA1 was associated with 1.73 mmHg increase in DBP.
  
  
  CONCLUSIONS
  High levels of HbA1 may be associated with increased blood pressure in T1DM. A tight control of HbA1 levels may provide long-term cardiovascular protection in children and adolescents with T1DM.
authors.affiliation: Department of Physical Education, Graduation Program on Physical Education-Catholic University of Brasilia (UCB), Q.S 7, lote 1-Bloco G-Aguas Claras, Taguatinga, Federal District, Brasilia, DF 71966-700 Brazil.
authors.forename: Sandra
authors.initials: S
authors.lastname: de Oliveira
authors.affiliation: Department of Physical Education, Graduation Program on Physical Education-Catholic University of Brasilia (UCB), Q.S 7, lote 1-Bloco G-Aguas Claras, Taguatinga, Federal District, Brasilia, DF 71966-700 Brazil.
authors.forename: Dahan
authors.initials: D
authors.lastname: da Cunha Nascimento
authors.affiliation: Department of Physical Education, Graduation Program on Physical Education-Catholic University of Brasilia (UCB), Q.S 7, lote 1-Bloco G-Aguas Claras, Taguatinga, Federal District, Brasilia, DF 71966-700 Brazil.
authors.forename: Ramires Alsamir
authors.initials: RA
authors.lastname: Tibana
authors.affiliation: Department of Physical Education, Graduation Program on Physical Education-Catholic University of Brasilia (UCB), Q.S 7, lote 1-Bloco G-Aguas Claras, Taguatinga, Federal District, Brasilia, DF 71966-700 Brazil.
authors.forename: Samuel Lima
authors.initials: SL
authors.lastname: de Oliveira
authors.affiliation: Department of Physical Education, Graduation Program on Physical Education-Catholic University of Brasilia (UCB), Q.S 7, lote 1-Bloco G-Aguas Claras, Taguatinga, Federal District, Brasilia, DF 71966-700 Brazil.
authors.forename: Ivo Vieira
authors.initials: IV
authors.lastname: de Sousa Neto
authors.affiliation: Endocrinology Unity-Research Polo Foundation for Teaching and Research in Health Sciences-Regional Hospital of Taguatinga, Federal District, Brasilia, Brazil.
authors.forename: Roberta Kelly Menezes Maciel
authors.initials: RK
authors.lastname: Falleiros
authors.affiliation: Endocrinology Unity-Research Polo Foundation for Teaching and Research in Health Sciences-Regional Hospital of Taguatinga, Federal District, Brasilia, Brazil.
authors.forename: Leonardo Garcia
authors.initials: LG
authors.lastname: Miranda
authors.affiliation: Endocrinology Unity-Research Polo Foundation for Teaching and Research in Health Sciences-Regional Hospital of Taguatinga, Federal District, Brasilia, Brazil.
authors.forename: Hermelinda Cordeiro
authors.initials: HC
authors.lastname: Pedrosa
authors.affiliation: Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, USA.
authors.forename: James Wilfred
authors.initials: JW
authors.lastname: Navalta
authors.affiliation: Department of Physical Education, Graduation Program on Physical Education-Catholic University of Brasilia (UCB), Q.S 7, lote 1-Bloco G-Aguas Claras, Taguatinga, Federal District, Brasilia, DF 71966-700 Brazil.
authors.forename: Guilherme Borges
authors.initials: GB
authors.lastname: Pereira
authors.affiliation: Department of Physical Education, Graduation Program on Physical Education-Catholic University of Brasilia (UCB), Q.S 7, lote 1-Bloco G-Aguas Claras, Taguatinga, Federal District, Brasilia, DF 71966-700 Brazil.
authors.forename: Jonato
authors.initials: J
authors.lastname: Prestes
keywords: Cardiovascular health; Childhood; Diabetes; Glycated hemoglobin; Hypertension