title: [Clinical analysis of liver transplantation for autoimmune hepatitis].
abstract: OBJECTIVE
  To describe the outcomes and recurrence of autoimmune hepatitis (AIH) after liver transplantation.
  
  
  METHODS
  Clinical data of 16 patients with AIH who underwent liver transplantation were analyzed retrospectively. The postoperative cumulative survival rate of the patients was calculated. The postoperative rejections and AIH recurrence were analyzed. The Kaplan-Meier method was used for statistical analysis of survival.
  
  
  RESULTS
  All patients were female, with an average age of 52.6 years (range: 41-66 years), and an average MELD score of 21.4. According serological analysis, 15 patients were AIH type 1 and 1 patient was AIH type 2. Three patients died, including 2 of pulmonary infection and 1 of graft dysfunction.The 1-, 2-and 5-year cumulative survival rates were 93.8%, 87.1% and 79.1%, respectively. Five cases (31.3%) of recurrent AIH were diagnosed based on histological evidence. Acute rejection occurred in 6 (37.5%) patients, and de novo HBV infection occurred in 1 (6.3%) patient.
  
  
  CONCLUSIONS
  Liver transplantation is an effective treatment for end-stage AIH. Recurrence and rejection were commonly associated with AIH, but did not negatively impact patient survival.
authors.affiliation: Liver Transplantation Center, 302 Hospital of PLA, Beijing 100039, China.
authors.forename: Shuang-Nan
authors.initials: SN
authors.lastname: Zhou
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Su
authors.forename: Yin-Jie
authors.initials: YJ
authors.lastname: Gao
authors.forename: Xia
authors.initials: X
authors.lastname: Zhou
authors.forename: Xi
authors.initials: X
authors.lastname: He
authors.forename: Jin-Xu
authors.initials: JX
authors.lastname: Chen
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Zhen-Wen
authors.initials: ZW
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019693:Hepatitis, Autoimmune / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation; D008875:Middle Aged; D011184:Postoperative Period; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome