title: Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity.
abstract: It has been confirmed that mitochondrial impairment may underlie both sporadic and familial Parkinson's disease (PD). Mitochondrial fission/fusion and biogenesis are key processes in regulating mitochondrial homeostasis. Therefore, we explored whether the protective effect of resveratrol in rotenone-induced neurotoxicity was associated with mitochondrial fission/fusion and biogenesis. The results showed that resveratrol could not only promote mitochondrial mass and DNA copy number but also improve mitochondrial homeostasis and neuron function in rats and PC12 cells damaged by rotenone. We also observed effects with alterations in proteins known to regulate mitochondrial fission/fusion and biogenesis in rotenone-induced neurotoxicity. Therefore, our findings suggest that resveratrol may prevent rotenone-induced neurotoxicity through regulating mitochondrial fission/fusion and biogenesis.
authors.affiliation: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Kaige
authors.initials: K
authors.lastname: Peng
authors.affiliation: College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tao
authors.affiliation: College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.affiliation: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Guorong
authors.initials: G
authors.lastname: Dan
authors.affiliation: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yuanpeng
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jiqing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Zou
authors.affiliation: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Cao
authors.affiliation: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sai
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004272:DNA, Mitochondrial / Q000235:genetics; D018628:Gene Dosage; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D063154:Mitochondrial Dynamics / Q000187:drug effects / Q000235:genetics*; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology; D009498:Neurotoxins / Q000633:toxicity*; D001678:Organelle Biogenesis; D016716:PC12 Cells; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D045442:Rotarod Performance Test; D012402:Rotenone / Q000633:toxicity*; D013267:Stilbenes / Q000494:pharmacology*; D016019:Survival Analysis; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D004272:DNA, Mitochondrial; D018696:Neuroprotective Agents; D009498:Neurotoxins; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C501429:Ppargc1a protein, rat; D017382:Reactive Oxygen Species; D013267:Stilbenes; D014157:Transcription Factors; D012402:Rotenone; D000255:Adenosine Triphosphate; D000077185:Resveratrol