title: [Direct oral anticoagulants: what is the exact assessment of coagulation tests and plasma levels by laboratory tests in clinical practice?].
abstract: Direct oral anticoagulants (DAO), anti-IIa or anti-Xa, are intended to be widely used for the treatment and prevention of thrombotic disorders in venous thromboembolic disease and atrial fibrillation as an alternative of vitamin K antagonists (VKA). Despite predictable pharmacological properties, spontaneous or provoked hemorrhagic risks by DAO are major limitations. Thus, after few years of inconsistence concerning biological implication and in particular coagulation tests, it is now established that we need biology to evaluate hemorrhagic risk before surgery or in hemorrhagic cases.
authors.affiliation: Service d'hématologie biologique, Hôpital européen Georges Pompidou, AP-HP, Paris, France, Université Paris Descartes, Sorbonne Paris Cité, France, Inserm UMR-S1140, Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gendron
authors.affiliation: Service d'hématologie biologique, Hôpital européen Georges Pompidou, AP-HP, Paris, France, Université Paris Descartes, Sorbonne Paris Cité, France, Inserm UMR-S1140, Paris, France.
authors.forename: David M
authors.initials: DM
authors.lastname: Smadja
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics; D001774:Blood Chemical Analysis / Q000379:methods / Q000706:statistics & numerical data; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D001780:Blood Coagulation Tests; D019411:Clinical Laboratory Techniques / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data; D013923:Thromboembolism / Q000097:blood* / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants
keywords: apixaban; coagulation test; dabigatran; direct oral anticoagulants; rivaroxaban