title: Two-dimensional honeycomb network through sequence-controlled self-assembly of oligopeptides.
abstract: The sequence of a peptide programs its self-assembly and hence the expression of specific properties through non-covalent interactions. A large variety of peptide nanostructures has been designed employing different aspects of these non-covalent interactions, such as dispersive interactions, hydrogen bonding or ionic interactions. Here we demonstrate the sequence-controlled fabrication of molecular nanostructures using peptides as bio-organic building blocks for two-dimensional (2D) self-assembly. Scanning tunnelling microscopy reveals changes from compact or linear assemblies (angiotensin I) to long-range ordered, chiral honeycomb networks (angiotensin II) as a result of removal of steric hindrance by sequence modification. Guided by our observations, molecular dynamic simulations yield atomistic models for the elucidation of interpeptide-binding motifs. This new approach to 2D self-assembly on surfaces grants insight at the atomic level that will enable the use of oligo- and polypeptides as large, multi-functional bio-organic building blocks, and opens a new route towards rationally designed, bio-inspired surfaces.
authors.affiliation: Max Planck Institute for Solid State Research, Heisenbergstraße 1, 70569 Stuttgart, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Abb
authors.forename: Ludger
authors.initials: L
authors.lastname: Harnau
authors.affiliation: Max Planck Institute for Solid State Research, Heisenbergstraße 1, 70569 Stuttgart, Germany.
authors.forename: Rico
authors.initials: R
authors.lastname: Gutzler
authors.affiliation: Max Planck Institute for Solid State Research, Heisenbergstraße 1, 70569 Stuttgart, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Rauschenbach
authors.affiliation: Max Planck Institute for Solid State Research, Heisenbergstraße 1, 70569 Stuttgart, Germany.|Institut de Physique de la Matière Condensée, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
authors.forename: Klaus
authors.initials: K
authors.lastname: Kern
mesh_terms: D000803:Angiotensin I / Q000737:chemistry / Q000378:metabolism*; D000804:Angiotensin II / Q000737:chemistry / Q000378:metabolism*; D016252:Microscopy, Scanning Tunneling; D056004:Molecular Dynamics Simulation; D049329:Nanostructures / Q000648:ultrastructure*; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D009842:Oligopeptides; D010455:Peptides; D000804:Angiotensin II; D000803:Angiotensin I