title: Constituents of the Stem of Nauclea orientalis.
abstract: A new α-pinene derivative (1) was isolated from the stem of Nauclea orientalis (L.) L. (Rubiaceae), together with twelve known compounds, including four terpenoids, loganetin (2), loganin (3), sweroside (4), grandifloroside (5), four simple phenols, methyl protocatechuate (6), trans-p-coumaric acid (7), 3-(2,4- dihydroxylphenyl)propanoic acid (8), methyl 3-(2,4-dihydroxylphenyl)propanoate (9), two coumarin glucosides, skimmin (10), adicardin (11), an anthraquinone, aloe emodin (12), and a lignan, (+)-pinoresinol (13). Their structures were elucidated on the basis of spectroscopic data. All compounds were tested for DPPH free radical scavenging and lipid peroxidation inhibitory activities. Among them, compounds 5 and 6 displayed strong antioxidant activity with IC50 values of 6.6 and 67.9 µM, 12.4 and 813.0 µM, respectively.
authors.forename: Phan Thi Anh
authors.initials: PT
authors.lastname: Dao
authors.forename: Tran Le
authors.initials: TL
authors.lastname: Quan
authors.forename: Nguyen Thi Thanh
authors.initials: NT
authors.lastname: Mai
mesh_terms: D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D018547:Plant Stems / Q000737:chemistry*; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D016166:Free Radical Scavengers; D010936:Plant Extracts