title: Natural Cosmeceutical Ingredients for Hyperpigmentation.
abstract: As Dermatologists caring for patients with hyperpigmentation problems, we are always looking for more alternative therapies. Hydroquinone (HQ) is still the standard of care. However, traditional depigmenting agents such as HQ and corticosteroids, although highly effective, can raise safety concerns including exogenous ochronosis, atrophy, carcinogenesis and local and systemic untoward effects with long term use. Therefore, we need to investigate non-prescription natural alternatives. This manuscript presents many of the natural ingredients found in cosmeceuticals for the treatment of hyperpigmentation and their mechanisms of action. It will also describe the melanocyte activation pathways and how each of these ingredients interferes with it.
authors.forename: Noelani
authors.initials: N
authors.lastname: Gonzalez
authors.forename: Maritza
authors.initials: M
authors.lastname: Perez
mesh_terms: D001104:Arbutin / Q000627:therapeutic use; D000068937:Cosmeceuticals / Q000032:analysis / Q000627:therapeutic use*; D006801:Humans; D006873:Hydroquinones / Q000627:therapeutic use; D017495:Hyperpigmentation / Q000188:drug therapy*; D008544:Melanocytes / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts / Q000627:therapeutic use; D013025:Glycine max; D014801:Vitamin A / Q000627:therapeutic use
chemical_list: D000068937:Cosmeceuticals; D006873:Hydroquinones; D010936:Plant Extracts; D014801:Vitamin A; D001104:Arbutin; C031927:hydroquinone