title: Prostaglandin E2Levels of Aqueous and Vitreous Humor in Ketorolac 0.4% and Nepafenac 0.1% Administered Healthy Rabbits.
abstract: OBJECTIVE
  To compare the lowering effects of ketorolac 0.4% and nepafenac 0.1% on aqueous and vitreous humor prostaglandin E2(PGE2) levels in rabbits.
  
  
  METHODS
  Ketorolac and nepafenac ophthalmic solutions were administered to the right eyes of 24 healthy rabbits after randomized division into two groups. The left eyes of these rabbits were considered as controls for the two groups. On the 4th day of the experiment, the samples were taken from the aqueous and vitreous humors of the rabbits bilaterally, and PGE2levels were measured by an enzyme immune assay kit.
  
  
  RESULTS
  Ketorolac and nepafenac achieved a statistically significant decrease (p<0.001, for each) in PGE2levels in the aqueous (11.75 ± 6.15 and 14.75 ± 7.60 pg/mL, respectively) and the vitreous humor (6.58 ± 4.62 and 9.83 ± 4.55 pg/mL, respectively).
  
  
  CONCLUSIONS
  Both ketorolac and nepafenac inhibited PGE2levels in both the aqueous and vitreous humors of rabbits. Although PGE2-lowering effects were similar in the aqueous humor, nepafenac seemed to be more potent than ketorolac in the vitreous humor.
authors.affiliation: a Department of Ophthalmology , Hacettepe University, Faculty of Medicine , Ankara , Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Acar
authors.affiliation: b Department of Ophthalmology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Damla Erginturk
authors.initials: DE
authors.lastname: Acar
authors.affiliation: c Department of Ophthalmology , İstanbul Medipol University , İstanbul , Turkey.
authors.forename: Cafer
authors.initials: C
authors.lastname: Tanriverdi
authors.affiliation: d Department of Ophthalmology , Dışkapı Yıldırım Beyazıt Research and Education Hospital , Ankara , Turkey.
authors.forename: Mutlu
authors.initials: M
authors.lastname: Acar
authors.affiliation: b Department of Ophthalmology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Ozdemir
authors.initials: O
authors.lastname: Ozdemir
authors.affiliation: e Department of Biochemistry , Hacettepe University, Faculty of Pharmacy , Ankara , Turkey.
authors.forename: Acelya
authors.initials: A
authors.lastname: Erikci
authors.affiliation: f Department of Ophthalmology , Ankara Research and Education Hospital , Ankara , Turkey.
authors.forename: Firdevs
authors.initials: F
authors.lastname: Ornek
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001082:Aqueous Humor / Q000378:metabolism*; D044482:Benzeneacetamides / Q000008:administration & dosage*; D015232:Dinoprostone / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D020910:Ketorolac / Q000008:administration & dosage*; D009883:Ophthalmic Solutions; D010648:Phenylacetates / Q000008:administration & dosage*; D011817:Rabbits; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044482:Benzeneacetamides; D009883:Ophthalmic Solutions; D010648:Phenylacetates; C414203:nepafenac; D015232:Dinoprostone; D020910:Ketorolac
keywords: Amfenac; PGE2; aqueous humor; ketorolac; nepafenac; vitreous humor