title: α-Fluoroallenoate Synthesis via N-Heterocyclic Carbene-Catalyzed Fluorination Reaction of Alkynals.
abstract: The first catalytic α-fluoroallenoate synthesis is described. With a suitable combination of N-heterocyclic carbene precatalyst, base, and fluorine reagent, the reaction proceeded smoothly to yield a wide range of α-fluoroallenoates with excellent chemoselectivity. These substituted α-fluorinated allenoates have been synthesized for the first time, and they are versatile synthetic intermediates toward other useful fluorine-containing building blocks.
authors.affiliation: Department of Pharmacology and Pharmaceutical Science, School of Medicine, Tsinghua University , Beijing 117543, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pharmacology and Pharmaceutical Science, School of Medicine, Tsinghua University , Beijing 117543, China.
authors.forename: Zijun
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Pharmacology and Pharmaceutical Science, School of Medicine, Tsinghua University , Beijing 117543, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang