title: An evaluation of homocysteine, C-reactive protein, lipid levels, neutrophils to lymphocyte ratio in postmenopausal osteopenic women.
abstract: OBJECTIVE
  In the present study, the risk coefficients of serum homocysteine (hcy), lipid levels, C-reactive protein (CRP), neutrophils to lymphocyte ratio (NLR) in postmenopausal osteopenic women were determined.
  
  
  METHODS
  We enrolled 269 patients with postmenopausal women from Hangzhou No.1 Hospital gynecological clinic, who aged 45 to 60 years old and never received menopause hormone therapy. According to the bone mineral density determination results, subjects were divided into normal group (n  =  128), osteopenia group (n  =  141). Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA). Serum hcy, CRP and lipid indexes were determined by enzyme chemiluminescence immunoassay.
  
  
  RESULTS
  The odds ratios (OR) and 95% confidence intervals (CI) of those variables (menopausal age, duration of menopause, LDL, CRP, hcy and NLR) were found significant (p  <  0.05). Menopausal age, duration of menopause, LDL, CRP, hcy and NLR variables were found statistically significant in the analysis of receiver operating characteristic (ROCs).
  
  
  CONCLUSIONS
  The present study shows that menopause age, duration of menopause, serum LDL, CRP, hcy and NLR levels are risk factors for postmenopausal osteopenic women, which may be used as the indicators of bone loss in postmenopausal women.
authors.affiliation: a Department of Gynecological Endocrinology and.|b Department of Obstetrics and Gynecology, Nanjing Medical University, Hangzhou Maternity Hospital , Hangzhou , China.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Liu
authors.affiliation: b Department of Obstetrics and Gynecology, Nanjing Medical University, Hangzhou Maternity Hospital , Hangzhou , China.
authors.forename: Zheren
authors.initials: Z
authors.lastname: Huang
authors.affiliation: b Department of Obstetrics and Gynecology, Nanjing Medical University, Hangzhou Maternity Hospital , Hangzhou , China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Tang
authors.affiliation: b Department of Obstetrics and Gynecology, Nanjing Medical University, Hangzhou Maternity Hospital , Hangzhou , China.
authors.forename: Shuangshuang
authors.initials: S
authors.lastname: Wei
authors.affiliation: a Department of Gynecological Endocrinology and.|b Department of Obstetrics and Gynecology, Nanjing Medical University, Hangzhou Maternity Hospital , Hangzhou , China.
authors.forename: Zhifen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D001851:Bone Diseases, Metabolic / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count; D008074:Lipoproteins / Q000097:blood*; D008214:Lymphocytes; D008875:Middle Aged; D009504:Neutrophils; D017698:Postmenopause / Q000097:blood*
chemical_list: D008074:Lipoproteins; D006710:Homocysteine; D002097:C-Reactive Protein
keywords: C-reactive protein; homocysteine; lipid; neutrophils to lymphocyte ratio; osteopenia; postmenopausal