title: Abnormal Amygdala Resting-State Functional Connectivity in Irritable Bowel Syndrome.
abstract: Functional neuroimaging studies in irritable bowel syndrome have revealed abnormalities in the corticolimbic regions, specifically, hyperactivity of the amygdala during visceral and somatic stimulation. This study investigated changes in the neural circuitry of the amygdala in patients with irritable bowel syndrome based on resting-state functional connectivity.
  
  
  
  Functional MR imaging data were acquired from 31 patients with irritable bowel syndrome and 32 healthy controls (matched for age, sex, and educational level) during rest, and the resting-state functional connectivity of bilateral amygdalae was compared. Multiple regression was performed to investigate the relationship between clinical indices of patients with irritable bowel syndrome and resting-state functional connectivity.
  
  
  
  Compared with healthy controls, patients with irritable bowel syndrome had higher positive resting-state functional connectivity between the amygdala and insula, midbrain, parahippocampal gyrus, pre- and postcentral gyri, and supplementary motor area. The inclusion of anxiety and depression as covariates did not alter amygdala resting-state functional connectivity differences between the study groups. Multiple covariate regression results showed that the pain intensity in patients with irritable bowel syndrome positively correlated with resting-state functional connectivity between the amygdala and supplementary motor area, pre- and postcentral gyri, and insula, while the Irritable Bowel Syndrome-Symptom Severity Score positively correlated with resting-state functional connectivity between the amygdala and insula and midbrain.
  
  
  
  Patients with irritable bowel syndrome showed disturbed amygdala resting-state functional connectivity with the corticolimbic regions, which could partly account for the enhanced emotional arousal and visceral information processing associated with irritable bowel syndrome.
authors.affiliation: From the Departments of Medical Imaging (R.Q., J.K., Q.X., L.J.Z., G.M.L.).
authors.forename: R
authors.identifier: 0000-0002-9981-9918
authors.initials: R
authors.lastname: Qi
authors.affiliation: Gastroenterology (C.L., Y.Y., F.W.).
authors.forename: C
authors.identifier: 0000-0003-2516-9059
authors.initials: C
authors.lastname: Liu
authors.affiliation: From the Departments of Medical Imaging (R.Q., J.K., Q.X., L.J.Z., G.M.L.).
authors.forename: J
authors.identifier: 0000-0002-8285-2084
authors.initials: J
authors.lastname: Ke
authors.affiliation: From the Departments of Medical Imaging (R.Q., J.K., Q.X., L.J.Z., G.M.L.).
authors.forename: Q
authors.identifier: 0000-0002-7178-0847
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Gastroenterology (C.L., Y.Y., F.W.).
authors.forename: Y
authors.identifier: 0000-0001-8377-5482
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Emergency Medicine (L.J.), Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
authors.forename: L
authors.identifier: 0000-0002-1863-5640
authors.initials: L
authors.lastname: Jia
authors.affiliation: Gastroenterology (C.L., Y.Y., F.W.).
authors.forename: F
authors.identifier: 0000-0001-5261-8556
authors.initials: F
authors.lastname: Wang
authors.affiliation: From the Departments of Medical Imaging (R.Q., J.K., Q.X., L.J.Z., G.M.L.) kevinzhlj@163.com cjr.luguangming@vip.163.com.
authors.forename: L J
authors.identifier: 0000-0002-6664-7224
authors.initials: LJ
authors.lastname: Zhang
authors.affiliation: From the Departments of Medical Imaging (R.Q., J.K., Q.X., L.J.Z., G.M.L.) kevinzhlj@163.com cjr.luguangming@vip.163.com.
authors.forename: G M
authors.identifier: 0000-0003-4913-2314
authors.initials: GM
authors.lastname: Lu
mesh_terms: D000328:Adult; D000679:Amygdala / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male