title: Identification and analysis of antinutritional factors in possible interactions between medications and food/nutrients in hospitalized patients.
abstract: OBJECTIVE
  To identify and analyze the presence of antinutritional factors in possible interactions between medications and foods/ nutrients of the diets prescribed for patients of the Hospital Regional Justino Luz, in the city of Picos (PI) in order to suggest their likely mechanisms.
  
  
  METHODS
  The sample was made up of 120 medical records of hospitalized patients. The charts were analyzed to verify the presence or absence of interactions between medications and foods/nutrients of the diets prescribed to the patients at the Hospital Regional Justino Luz, emphasizing the action of antinutritional factors in these interactions.
  
  
  RESULTS
  Of the 189 medications prescribed, 128 (67.7%) had a possible interaction with food, totaling up 98 possible interactions between nutrients/foods and medications. Therefore, 20 (20.4%), 12 (12.2%) and 11 (11.2%) possible interactions were identified with captopril, acetylsalicylic acid and spironolactone, respectively, representing, in this order, the greatest frequencies of possible interactions among drugs and foods. A total of nine antinutritional factors were found in seven vegetable foods prescribed to inpatients, in which five (55.6%) were capable of interacting with the medications. Phytates and tannins had the largest quantity of possible interactions with drugs, each with 4 (26.7%) in a total of 15 interactions. The medications aluminum hydroxide, digoxin, and paracetamol attained greater probability of interaction with antinutrients, with 5 (33.3%), 3 (20%) and 3 (20%) interactions, respectively.
  
  
  CONCLUSIONS
  Due to the large quantity of antinutritional factors capable of interacting with drugs prescribed for inpatients, the involvement of a multiprofessional team is indispensable so that these possible interactions between foods, antinutritional factors and drugs might be foreseen, detected, and resolved.
authors.affiliation: Universidade Federal do Piauí - UFPI, Teresina, PI, BR.
authors.forename: Adnny Fernanda Lima
authors.initials: AF
authors.lastname: Campos
authors.affiliation: Universidade Federal do Piauí - UFPI, Teresina, PI, BR.
authors.forename: Savina Pereira
authors.initials: SP
authors.lastname: Torres
authors.affiliation: Universidade Federal do Piauí - UFPI, Teresina, PI, BR.
authors.forename: Everton Moraes
authors.initials: EM
authors.lastname: Lopes
authors.affiliation: Universidade Federal do Piauí - UFPI, Teresina, PI, BR.
authors.forename: Rumão Batista Nunes de
authors.initials: RB
authors.lastname: Carvalho
authors.affiliation: Universidade Federal do Piauí - UFPI, Teresina, PI, BR.
authors.forename: Rivelilson Mendes de
authors.initials: RM
authors.lastname: Freitas
authors.affiliation: Universidade Federal do Piauí - UFPI, Teresina, PI, BR.
authors.forename: Lívio César Cunha
authors.initials: LC
authors.lastname: Nunes