title: Proline-based phosphoramidite reagents for the reductive ligation of S-nitrosothiols.
abstract: S-Nitrosothiols (RSNOs) have many biological implications but are rarely used in organic synthesis. In this work we report the development of proline-based phosphoramidite substrates that can effectively convert RSNOs to proline-based sulfenamides through a reductive ligation process. A unique property of this method is that the phosphine oxide moiety on the ligation products can be readily removed under acidic conditions. In conjugation with the facile preparation of RSNOs from the corresponding thiols (RSHs), this method provides a new way to prepare proline-based sulfenamides from simple thiol starting materials.
authors.affiliation: Department of Chemistry, Washington State University, Pullman, WA 99164, United States.
authors.forename: Chung-Min
authors.initials: CM
authors.lastname: Park
authors.affiliation: Department of Chemistry, Washington State University, Pullman, WA 99164, United States.
authors.forename: Tyler D
authors.initials: TD
authors.lastname: Biggs
authors.affiliation: Department of Chemistry, Washington State University, Pullman, WA 99164, United States.
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
mesh_terms: D009569:Nitric Oxide / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010720:Phosphines / Q000737:chemistry; D011392:Proline / Q000737:chemistry*; D026403:S-Nitrosothiols / Q000737:chemistry*; D013416:Sulfamerazine / Q000737:chemistry
chemical_list: D009943:Organophosphorus Compounds; D010720:Phosphines; D026403:S-Nitrosothiols; C434331:phosphoramidite; C471392:sulfenamide; D009569:Nitric Oxide; D011392:Proline; C044646:phosphine; D013416:Sulfamerazine