title: Differences between buccal and lingual bone quality and quantity of peri-implant regions.
abstract: The objective of the current study was to examine whether peri-implant bone tissue properties are different between the buccal and lingual regions treated by growth factors. Four dental implant groups were used: titanium (Ti) implants, alumina-blasted zirconia implants (ATZ-N), alumina-blasted zirconia implants with demineralized bone matrix (DBM) (ATZ-D), and alumina-blasted zirconia implants with rhBMP-2 (ATZ-B). These implants were placed in mandibles of six male dogs. Nanoindentation elastic modulus (E) and plastic hardness (H) were measured for the buccal and lingual bone tissues adjacent and away from the implants at 3 and 6 weeks post-implantation. A total of 2281 indentations were conducted for 48 placed implants. The peri-implant buccal region had less bone quantity resulting from lower height and narrower width of bone tissue than the lingual region. Buccal bone tissues had significant greater mean values of E and H than lingual bone tissues at each distance and healing period (p<0.007). Nearly all implant treatment groups displayed lower mean values of the E at the lingual bone tissues than at the buccal bone tissues (p<0.046) although the difference was not significant for the Ti implant group (p=0.758). The DBM and rhBMP-2 treatments stimulated more peri-implant bone remodeling at the lingual region, producing more immature new bone tissues with lower E than at the buccal region. This finding suggests that the growth factor treatments to the zirconia implant system may help balance the quantity and quality differences between the peri-implant bone tissues.
authors.affiliation: Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA. Electronic address: kim.2508@osu.edu.
authors.forename: Do-Gyoon
authors.initials: DG
authors.lastname: Kim
authors.affiliation: Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Kathy L
authors.initials: KL
authors.lastname: Elias
authors.affiliation: Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Yong-Hoon
authors.initials: YH
authors.lastname: Jeong
authors.affiliation: Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Kwon
authors.affiliation: Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Clements
authors.affiliation: Division of Restorative Science and Prosthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Brantley
authors.affiliation: Division of Restorative Science and Prosthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Damian J
authors.initials: DJ
authors.lastname: Lee
authors.affiliation: Department of Prosthodontics, Seoul National University, Seoul, Republic of Korea.
authors.forename: Jung-Suk
authors.initials: JS
authors.lastname: Han
mesh_terms: D000818:Animals; D016723:Bone Remodeling; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004285:Dogs; D006928:Hyoid Bone / Q000502:physiology*; D008297:Male; D008334:Mandible / Q000502:physiology*
chemical_list: D015921:Dental Implants
keywords: Bone morphogenetic protein-2; Bone remodeling; Growth factors; Nanoindentation; Peri-implant bone