title: Curcumin and β-caryophellene attenuate cadmium quantum dots induced oxidative stress and lethality in Caenorhabditis elegans model system.
abstract: Curcumin (CUR) and β-caryophellene (BCP) are well known bioactive phytomolecules which are known to reduce oxidative stress in living organisms. Therefore, the present study was envisaged to explore the possible effects of CUR and BCP in suppression of cadmium quantum dots (CdTe QDs) induced toxicity in Caenorhabditis elegans. CdTe QD are luminescent nanoparticles extensively exploited for in vivo imaging, but long term bioaccumulation confer deleterious effects on living organisms. The 24-h LC50 and LC100 of CdTe QD were found to be 18.40 μg/ml and 100 μg/ml respectively. The CdTe QD exposure elevated HSP-16.2 expression mediating induction of the stress response. The CdTe QD lethality was due to increment in ROS and decline in SOD and GST expression. The present study demonstrates improved survival in BCP (50 μM) and CUR (20 μM) treated worms by over 60% (P<0.01) and 50% (P<0.029) in CdTe QD (100 μg/ml) exposed worms. Furthermore, BCP and CUR attenuate oxidative stress triggered by QD. The present study for the first time demonstrates CdTe QD toxicity remediation via BCP and CUR. The future investigations can unravel underlying protective effects of phytomolceules for remediating cyotoxicolgical effects of QDs.
authors.affiliation: Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, India.
authors.forename: Swati
authors.initials: S
authors.lastname: Srivastava
authors.affiliation: Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, India.
authors.forename: Aakanksha
authors.initials: A
authors.lastname: Pant
authors.affiliation: Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, India.
authors.forename: Shalini
authors.initials: S
authors.lastname: Trivedi
authors.affiliation: Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, India. Electronic address: r.pandey@cimap.res.in.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Pandey
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002104:Cadmium / Q000633:toxicity*; D017173:Caenorhabditis elegans; D003474:Curcumin; D008954:Models, Biological; D018384:Oxidative Stress / Q000187:drug effects; D000081223:Polycyclic Sesquiterpenes; D045663:Quantum Dots / Q000633:toxicity*; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D002104:Cadmium; C024714:caryophyllene; D003474:Curcumin
keywords: Cadmium quantum dots; Caenorhabditis elegans; Oxidative stress; Phytomolecules; Toxicity