title: Representation of memories in the cortical-hippocampal system: Results from the application of population similarity analyses.
abstract: Here we consider the value of neural population analysis as an approach to understanding how information is represented in the hippocampus and cortical areas and how these areas might interact as a brain system to support memory. We argue that models based on sparse coding of different individual features by single neurons in these areas (e.g., place cells, grid cells) are inadequate to capture the complexity of experience represented within this system. By contrast, population analyses of neurons with denser coding and mixed selectivity reveal new and important insights into the organization of memories. Furthermore, comparisons of the organization of information in interconnected areas suggest a model of hippocampal-cortical interactions that mediates the fundamental features of memory.
authors.affiliation: The Neuroscience Institute, NYU Langone Medical Center, United States.
authors.forename: Sam
authors.initials: S
authors.lastname: McKenzie
authors.affiliation: Center for Memory and Brain, Boston University, United States.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Keene
authors.affiliation: Center for Memory and Brain, Boston University, United States.
authors.forename: Anja
authors.initials: A
authors.lastname: Farovik
authors.affiliation: Center for Memory and Brain, Boston University, United States.
authors.forename: John
authors.initials: J
authors.lastname: Bladon
authors.affiliation: Center for Memory and Brain, Boston University, United States.
authors.forename: Ryan
authors.initials: R
authors.lastname: Place
authors.affiliation: Picower Institute for Learning and Memory, Massachusetts Institute of Technology, United States.
authors.forename: Robert
authors.initials: R
authors.lastname: Komorowski
authors.affiliation: Center for Memory and Brain, Boston University, United States.
authors.forename: Howard
authors.initials: H
authors.lastname: Eichenbaum
mesh_terms: D000818:Animals; D018728:Entorhinal Cortex / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D000071039:Perirhinal Cortex / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*
keywords: Entorhinal; Hippocampus; Memory; Orbitofrontal; Pattern separation; Schema