title: Current and emerging treatment options for interstitial lung disease in patients with rheumatic disease.
abstract: The management of connective tissue disease-associated interstitial lung disease (CTD-ILD) is complex and this arena offers many challenges to the practicing clinician. Unfortunately, treatment strategies and recommendations are often based on experience rather than evidence, and there are few effective therapeutic options. Pharmacologic intervention with immunosuppression is usually the mainstay of therapy and is reserved for those with clinically significant and/or progressive ILD. There is a desperate need for controlled trials across the spectrum of CTD-ILD and a number of potentially promising novel therapies warrant further study. It is important to address co-morbid conditions or aggravating factors (e.g., gastroesophageal reflux, aspiration, bone health, pulmonary hypertension, Pneumocystis jiroveci prophylaxis) and to institute non-pharmacologic management strategies (e.g., supplemental oxygen and cardiopulmonary rehabilitation) as part of a comprehensive treatment plan in CTD-ILD.
authors.affiliation: a Department of Medicine , University of Colorado School of Medicine , Aurora , CO , USA.
authors.forename: Joyce S
authors.initials: JS
authors.lastname: Lee
authors.affiliation: a Department of Medicine , University of Colorado School of Medicine , Aurora , CO , USA.
authors.forename: Aryeh
authors.initials: A
authors.lastname: Fischer
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000639:trends; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000628:therapy*; D010102:Oxygen Inhalation Therapy / Q000639:trends; D012216:Rheumatic Diseases / Q000150:complications*
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Connective tissue disease; interstitial lung disease; interstitial pneumonia; pulmonary fibrosis