title: Riboflavin Arrests Cisplatin-Induced Neurotoxicity by Ameliorating Cellular Damage in Dorsal Root Ganglion Cells.
abstract: Cis-Diamminedichloroplatinum II- (CP-) induced neurotoxicity is one of the least explored aspects of this drug. Dorsal root ganglia (DRG) cells are considered as the primary target, and their damage plays a vital role in pathogenesis and etiology of CP-induced neurotoxicity. The present study is aimed at confirming if riboflavin (RF) has any protective role in shielding the DRG from CP-induced toxicity. After conducting the established treatment strategy on mice under photoillumination, it was observed that, despite the fact that RF alone is partially toxic, its combination with CP significantly ameliorated the drug-induced damage in DRG cells as evidenced by histological analysis. In addition, it was interesting to observe that the combination group (RF + CP) was able to induce apoptosis in the target cells up to a significant extent which is considered as the most preferred way of countering cancer cells. Therefore, RF can act as an effective adjuvant compound in CP-based chemoradiotherapy to improve clinical outcomes in the contemporary anticancer treatment regimes.
authors.affiliation: Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India.
authors.forename: Maria
authors.initials: M
authors.lastname: Salman
authors.affiliation: Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India.
authors.forename: Imrana
authors.initials: I
authors.lastname: Naseem
authors.affiliation: Department of Zoology, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Iftekhar
authors.identifier: 0000-0001-6993-9954
authors.initials: I
authors.lastname: Hassan
authors.affiliation: Department of Anatomy, JNMCH, Aligarh Muslim University, Aligarh 202002, India.
authors.forename: Aijaz A
authors.initials: AA
authors.lastname: Khan
authors.affiliation: Department of Zoology, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Ibrahim M
authors.initials: IM
authors.lastname: Alhazza
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002945:Cisplatin / Q000009:adverse effects; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D020258:Neurotoxicity Syndromes / Q000188:drug therapy* / Q000473:pathology; D012256:Riboflavin / Q000008:administration & dosage*
chemical_list: D002945:Cisplatin; D012256:Riboflavin