title: Lifting the Mist on Gastric Stem Cells.
abstract: In a recent issue of Cancer Cell, Hayakawa et al. (2015) demonstrate that Mist1(+) gastric stem cells are supported by a specialized niche composed of Cxcl12(+) endothelium and Wnt5a-producing Cxcr4(+) innate lymphoid cells. In diffuse-type gastric cancer this perivascular stem cell niche is expanded and can be exploited for cancer therapy.
authors.affiliation: Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Varga
authors.affiliation: Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany. Electronic address: greten@gsh.uni-frankfurt.de.
authors.forename: Florian R
authors.initials: FR
authors.lastname: Greten
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D055153:Stem Cell Niche; D013274:Stomach Neoplasms / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D051792:Basic Helix-Loop-Helix Proteins