title: Role of Ebola Virus vp24 Protein in Inhibition of Interferonogenesis.
abstract: The effects of recombinant analog of natural Ebola virus protein vp24 in configurations virulent (vp24-ad) and avirulent (vp24-w) for guinea pigs on interferonogenesis were studied in vivo and in vitro. Amino acid differences were determined by His186 substitution in avirulent (nonlethal) configuration for Tyr in the virulent (lethal) one. Recombinant analogs vp24-w and vp24-ad inhibited interferonogenesis in vivo and in vitro. Inhibition by the two protein configurations was virtually the same.
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia. pathol@inbox.eu.
authors.forename: A A
authors.initials: AA
authors.lastname: Shelemba
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.affiliation: Institute of Basic and Clinical Immunology, Novosibirsk, Russia.
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyashchikh
authors.affiliation: Institute of Basic and Clinical Immunology, Novosibirsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Chepurnov
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy; D007369:Interferon Inducers / Q000494:pharmacology / Q000627:therapeutic use; D007372:Interferons / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D012330:RNA, Double-Stranded / Q000494:pharmacology / Q000627:therapeutic use; D012331:RNA, Fungal / Q000494:pharmacology / Q000627:therapeutic use; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; C446938:VP24 protein, Ebola virus; D014764:Viral Proteins; C076741:ridostin; D007372:Interferons
keywords: Ebola virus; interferon induction; vp24 protein