title: Rifampin-warfarin interaction in a mitral valve replacement patient receiving rifampin for infective endocarditis: a case report.
abstract: BACKGROUND
  Warfarin therapy is associated with many drug interactions that may cause a significant alteration in its anticoagulant effect. Rifampin is a widely used antimicrobial that has major interactions with several medications including warfarin due to its strong P-glycoprotein and liver enzyme inducer activity especially on CYP2C9, CYP3A4, CYP1A2 and CYP2C19.
  
  
  METHODS
  We report a case of a 34-year-old Srilankan female chronically treated with warfarin for her mitral valve replacement. The patient developed infective endocarditis and was started on a 6-week treatment with rifampin along with other antibiotics. Warfarin dose was increased from 52.5 to 210 mg/week over the course of the rifampin therapy, however, the INR remained subtherapeutic throughout the whole period and reached 2.4 by the end of rifampin therapy.
  
  
  RESULTS
  Anticoagulation management was challenging in the period following the end of rifampin therapy as well, and multiple dose adjustments starting with an increase and followed by reduction were required till she was stable on an 80 mg/week warfarin dose 5 weeks post-rifampin therapy.
  
  
  CONCLUSIONS
  Our findings suggest the importance of close monitoring of warfarin therapy during and after the use of rifampin to minimize the risks of under and over-anticoagulation and improve the safety and efficacy of warfarin therapy.
authors.affiliation: Clinical Pharmacist, Pharmacy department, Alwakra Hospital, P.O. Box: 82228, Doha, Qatar.
authors.forename: Amr Mohamed
authors.initials: AM
authors.lastname: Fahmi
authors.affiliation: Clinical Pharmacist, Pharmacy department, Alwakra Hospital, P.O. Box: 82228, Doha, Qatar.
authors.forename: Osama
authors.initials: O
authors.lastname: Abdelsamad
authors.affiliation: Clinical Pharmacy and Practice Section, College of Pharmacy, Qatar University, P.O. Box 2713, Doha, Qatar.
authors.forename: Hazem
authors.initials: H
authors.lastname: Elewa
keywords: Infective endocarditis; Mitral valve replacement; Rifampin; Warfarin