title: Evaluation of optimal water fluoridation on the incidence and skeletal distribution of naturally arising osteosarcoma in pet dogs.
abstract: Experimental toxicological studies in laboratory animals and epidemiological human studies have reported a possible association between water fluoridation and osteosarcoma (OSA). To further explore this possibility, a case-control study of individual dogs evaluated by the UC Davis Veterinary Medical Teaching Hospital was conducted using ecologic data on water fluoridation based on the owner's residence. The case group included 161 dogs with OSA diagnosed between 2008-2012. Two cancer control groups included dogs diagnosed with lymphoma (LSA) or hemangiosarcoma (HSA) during the same period (n = 134 and n = 145, respectively). Dogs with OSA were not significantly more likely to live in an area with optimized fluoride in the water than dogs with LSA or HSA. Additional analyses within OSA patients also revealed no significant differences in age, or skeletal distribution of OSA cases relative to fluoride status. Taken together, these analyses do not support the hypothesis that optimal fluoridation of drinking water contributes to naturally occurring OSA in dogs.
authors.affiliation: The Comparative Oncology Laboratory and Center for Companion Animal Health, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Rebhun
authors.affiliation: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: P H
authors.initials: PH
authors.lastname: Kass
authors.affiliation: The Comparative Oncology Laboratory and Center for Companion Animal Health, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Kent
authors.affiliation: UC Davis School of Veterinary Medicine, William R. Pritchard Veterinary Medical Teaching Hospital, University of California-Davis, Davis, CA, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: Watson
authors.affiliation: The Comparative Oncology Laboratory and Center for Companion Animal Health, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Withers
authors.affiliation: The Comparative Oncology Laboratory and Center for Companion Animal Health, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: W T N
authors.initials: WTN
authors.lastname: Culp
authors.affiliation: Department of Civil and Environmental Engineering, University of California-Davis, Davis, CA, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: King
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000662:veterinary*; D016022:Case-Control Studies; D004283:Dog Diseases / Q000139:chemically induced* / Q000453:epidemiology; D004285:Dogs; D005260:Female; D005457:Fluoridation / Q000009:adverse effects*; D015994:Incidence; D008297:Male; D012516:Osteosarcoma / Q000139:chemically induced / Q000453:epidemiology / Q000662:veterinary*
keywords: comparative oncology; epidemiology; oncology; small animal; tumour biology