title: Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives.
abstract: The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a diastolic dysfunction and cardiac remodelling without signs of hypertension and coronary artery diseases. In an early stage, it is an asymptomatic disease; however, clinical studies demonstrate that diabetic myocardia are more vulnerable to injury derived by acute myocardial infarct and are the worst prognosis for rehabilitation. Currently, biochemical and imaging diagnostic methods are unable to detect subclinical manifestation of the disease (prior to diastolic dysfunction). In this review, we elaborately discuss the current scientific evidences to propose circulating microRNAs as promising biomarkers for early detection of diabetic cardiomyopathy and, then, to identify patients at high risk of diabetic cardiomyopathy development. Moreover, here we summarise the research strategies to identify miRNAs as potential biomarkers, present limitations, challenges, and future perspectives.
authors.affiliation: Centro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, 7710162 Santiago, Chile.
authors.forename: Luis E
authors.initials: LE
authors.lastname: León
authors.affiliation: Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway, Ireland.
authors.forename: Sweta
authors.initials: S
authors.lastname: Rani
authors.affiliation: Clínica Alemana, 7650568 Santiago, Chile.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Fernandez
authors.affiliation: Clínica Alemana, 7650568 Santiago, Chile.
authors.forename: Martín
authors.initials: M
authors.lastname: Larico
authors.affiliation: Centro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, 7710162 Santiago, Chile.
authors.forename: Sebastián D
authors.initials: SD
authors.lastname: Calligaris
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D058065:Diabetic Cardiomyopathies / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D042241:Early Diagnosis; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs