title: Persistent DNA binding, cleavage performance and eco-friendly catalytic nature of novel complexes having 2-aminobenzophenone precursor.
abstract: This paper describes the synthesis of four novel bidentate metal(II) complexes having 2-aminobenzophenone precursor and a co-ligand (anthranilic acid). They are characterized by the usual spectral and analytical data. They adopt octahedral geometrical arrangements around the metal ions which have been confirmed by electronic absorption data. Moreover, the EPR study of Cu(II) complex has provided supportive evidence to the conclusion drawn on the basis of electronic spectrum and magnetic moment value. Powder XRD and SEM studies show that all the complexes are microcrystalline with homogenous morphology. The interaction of these complexes with CT-DNA has been explored by UV-absorption, fluorescence, viscosity, CV and CD techniques which reveal that the complexes could bind to CT-DNA through intercalation. The oxidative cleavage of the metal complexes with pBR322 DNA has also been investigated by gel electrophoresis. Moreover, the antimicrobial bustle shows that all metal chelates have superior activity than the free Schiff base ligand. The catalytic activity of the complexes has been evaluated towards the oxidation of aniline. All the complexes exhibit significant catalytic activity. Among them Cu(II) complex exhibits better catalytic activity than others. This catalytic process occurs at room temperature and it proceeds in water medium which suggests that this is an eco-friendly process.
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, Tamil Nadu, India.
authors.forename: Vellaichamy
authors.initials: V
authors.lastname: Muniyandi
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, Tamil Nadu, India.
authors.forename: Narayanaperumal
authors.initials: N
authors.lastname: Pravin
authors.affiliation: Department of Chemistry, Devanga Arts College, Aruppukottai 626 101, Tamil Nadu, India.
authors.forename: Paramasivam
authors.initials: P
authors.lastname: Subbaraj
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, Tamil Nadu, India. Electronic address: ramchem1964@gmail.com.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Raman
mesh_terms: D001577:Benzophenones / Q000737:chemistry*; D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D006868:Hydrolysis; D008855:Microscopy, Electron, Scanning; D033362:Powder Diffraction; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D001577:Benzophenones; D004247:DNA
keywords: Antimicrobial activity; Catalytic activity; Fluorescence; Oxidative cleavage; UV-absorption