title: Cancer Stem Cells: Plasticity Works against Therapy.
abstract: Great successes in identification and deciphering of mechanisms of the adult stem cells regulation have given rise to the idea that stem cells can also function in tumors as central elements of their development, starting from the initial stage and continuing until metastasis. Such cells were called cancer stem cells (CSCs). Over the course of intense discussion, the CSCs hypothesis gradually began to be perceived as an obvious fact. Recently, the existence of CSCs has been indeed confirmed in a number of works. However, when are CSCs universal prerequisites of tumors and to what extent their role is essential for tumor evolution remains an issue far from resolved. Likewise, the problem of potential use of CSCs as therapeutic targets remains unsolved. The present review attempts to analyze the issue of cancer stem cells and the potential of targeting them in tumor therapy.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
authors.forename: T V
authors.initials: TV
authors.lastname: Vinogradova
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
authors.forename: I P
authors.initials: IP
authors.lastname: Chernov
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
authors.forename: G S
authors.initials: GS
authors.lastname: Monastyrskaya
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
authors.forename: L G
authors.initials: LG
authors.lastname: Kondratyeva
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
authors.forename: E D
authors.initials: ED
authors.lastname: Sverdlov
keywords: cancer; cancer stem cells; clonal evolution; hierarchical structure of the tumor; stem cells