title: [Two Cases of Effective Hepatic Arterial Infusion Chemotherapy for Liver Metastases of Colon Cancer Resistant to Systemic Chemotherapy].
abstract: A 69-year-old man underwent right hemicolectomy for ascending colon cancer with liver metastases. Postoperative systemic chemotherapy did not reduce the metastases, and therefore, hepatic arterial infusion chemotherapy (HAI) was administered. The metastases decreased in size after 26 rounds of therapy, and the patient underwent resection. He is recurrence-free 63 months after the primary operation. A 57-year-old man underwent Hartmann's operation for sigmoid colon cancer with liver metastases. He underwent hepatic left lobe resection after metastases reduction by systemic chemotherapy. However, multiple liver metastases were detected 2 months later. Because the disease progressed despite the administration of systemic chemotherapy, HAI was utilized instead. The metastases decreased in size remarkably, and resection was performed. The patient is surviving 52 months after the primary operation while being continuously treated with HAI, resection, and systemic chemotherapy for re-recurrence. HAI is a potential alternative treatment for patients with colorectal liver metastases resistant to systemic chemotherapy.
authors.affiliation: Dept. of Surgery, University of Kurume.
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Date
authors.forename: Toru
authors.initials: T
authors.lastname: Hisaka
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Takahashi
authors.forename: Goichi
authors.initials: G
authors.lastname: Nakayama
authors.forename: Masanori
authors.initials: M
authors.lastname: Akashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kawahara
authors.forename: Hisamune
authors.initials: H
authors.lastname: Sakai
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yasunaga
authors.forename: Shinji
authors.initials: S
authors.lastname: Uchida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Horiuchi
authors.forename: Koji
authors.initials: K
authors.lastname: Okuda
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Matsunaga
authors.forename: Keisuke
authors.initials: K
authors.lastname: Miwa
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Akagi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003082:Colectomy; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed