title: Brain structural correlates of obsessive-compulsive disorder with and without preceding stressful life events.
abstract: Objectives There is growing evidence supporting a role for stressful life events (SLEs) at obsessive-compulsive disorder (OCD) onset, but neurobiological correlates of such effect are not known. We evaluated regional grey matter (GM) changes associated with the presence/absence of SLEs at OCD onset. Methods One hundred and twenty-four OCD patients and 112 healthy controls were recruited. Patients were split into two groups according to the presence (n = 56) or absence (n = 68) of SLEs at disorder's onset. A structural magnetic resonance image was acquired for each participant and pre-processed with Statistical Parametric Mapping software (SPM8) to obtain a volume-modulated GM map. Between-group differences in sociodemographic, clinical and whole-brain regional GM volumes were assessed. Results SLEs were associated with female sex, later age at disorder's onset, more contamination/cleaning and less hoarding symptoms. In comparison with controls, patients without SLEs showed GM volume increases in bilateral dorsal putamen and the central tegmental tract of the brainstem. By contrast, patients with SLEs showed specific GM volume increases in the right anterior cerebellum. Conclusions Our findings support the idea that neuroanatomical alterations of OCD patients partially depend on the presence of SLEs at disorder's onset.
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;|b Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) , Carlos III Health Institute , Spain ;
authors.forename: E
authors.initials: E
authors.lastname: Real
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;|b Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) , Carlos III Health Institute , Spain ;|c Department of Clinical Sciences, School of Medicine , University of Barcelona , Barcelona , Spain ;
authors.forename: M
authors.initials: M
authors.lastname: Subirà
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;|b Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) , Carlos III Health Institute , Spain ;|c Department of Clinical Sciences, School of Medicine , University of Barcelona , Barcelona , Spain ;
authors.forename: P
authors.initials: P
authors.lastname: Alonso
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;|b Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) , Carlos III Health Institute , Spain ;
authors.forename: C
authors.initials: C
authors.lastname: Segalàs
authors.affiliation: d Mental Health Department , Corporació Sanitària Parc Taulí , Sabadell , Spain ;|e Department of Psychiatry and Forensic Medicine , Universitat Autònoma De Barcelona , Barcelona , Spain ;
authors.forename: J
authors.initials: J
authors.lastname: Labad
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;
authors.forename: C
authors.initials: C
authors.lastname: Orfila
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;|b Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) , Carlos III Health Institute , Spain ;|c Department of Clinical Sciences, School of Medicine , University of Barcelona , Barcelona , Spain ;
authors.forename: C
authors.initials: C
authors.lastname: López-Solà
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;
authors.forename: I
authors.initials: I
authors.lastname: Martínez-Zalacaín
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;|c Department of Clinical Sciences, School of Medicine , University of Barcelona , Barcelona , Spain ;
authors.forename: E
authors.initials: E
authors.lastname: Via
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;|d Mental Health Department , Corporació Sanitària Parc Taulí , Sabadell , Spain ;|e Department of Psychiatry and Forensic Medicine , Universitat Autònoma De Barcelona , Barcelona , Spain ;
authors.forename: N
authors.initials: N
authors.lastname: Cardoner
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;|f Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CIBERobn) , Carlos III Health Institute , Madrid , Spain ;
authors.forename: S
authors.initials: S
authors.lastname: Jiménez-Murcia
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;|b Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) , Carlos III Health Institute , Spain ;|g Department of Psychobiology and Methodology in Health Sciences , Universitat Autònoma de Barcelona , Barcelona , Spain.
authors.forename: C
authors.initials: C
authors.lastname: Soriano-Mas
authors.affiliation: a Psychiatry Department , Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) , Barcelona , Spain ;|b Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) , Carlos III Health Institute , Spain ;|c Department of Clinical Sciences, School of Medicine , University of Barcelona , Barcelona , Spain ;
authors.forename: J M
authors.initials: JM
authors.lastname: Menchón
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D015897:Comorbidity; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007406:Interview, Psychological; D008016:Life Change Events; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000523:psychology; D009929:Organ Size / Q000502:physiology; D012016:Reference Values; D012307:Risk Factors; D013223:Statistics as Topic
keywords: MRI; Obsessive–compulsive disorder; anxiety disorders; brain imaging; stress