title: Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells.
abstract: Fibrosis and scarring are the end stage of many disease processes. In effect, the collagen fibers that initially provide a necessary strength during the repair of injured tissues are frequently synthesized in excessive amounts and become irreversible fibrotic deposits that limit regeneration of the endogenous cells of a tissue. This review will focus on the potential of mesenchymal stem/stromal cells for treatment of fibrotic diseases, with emphasis on the role of TSG-6 as a mediator of anti-inflammatory effects.
authors.affiliation: Institute for Regenerative Medicine, Texas A&M University, College of Medicine, Temple, TX, USA. Electronic address: Prockop@medicine.tamhsc.edu.
authors.forename: Darwin J
authors.initials: DJ
authors.lastname: Prockop
mesh_terms: D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000627:therapeutic use; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D002921:Cicatrix / Q000188:drug therapy / Q000473:pathology; D003094:Collagen / Q000235:genetics; D005355:Fibrosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D012038:Regeneration / Q000235:genetics
chemical_list: D015815:Cell Adhesion Molecules; C072273:TNFAIP6 protein, human; D003094:Collagen
keywords: Mesenchymal stem/stromal cells; Regenerative medicine; TSG-6; Tissue fibrosis