title: [(18)F]Choline PET/CT and stereotactic body radiotherapy on treatment decision making of oligometastatic prostate cancer patients: preliminary results.
abstract: BACKGROUND
  A new entity of patients with recurrent prostate cancer limited to a small number of active metastatic lesions is having growing interest: the oligometastatic patients. Patients with oligometastatic disease could eventually be managed by treating all the active lesions with local therapy, i.e. either surgery or ablative stereotactic body radiotherapy. This study aims to assess the impact of [(18)F]Choline ([(18)F]FMCH) PET/CT and the use stereotactic body radiotherapy (SBRT) in patients (pts) with oligometastatic prostate cancer (PCa).
  
  
  METHODS
  Twenty-nine pts with oligometastatic PCa (≤3 synchronous active lesions detected with [(18)F]FMCHPET/CT) were treated with repeated salvage SBRT until disease progression (development of > three active synchronous metastases). Primary endpoint was systemic therapy-free survival measured from the baseline [(18)F]FMCHPET/CT.
  
  
  RESULTS
  A total of 45 lesions were treated with SBRT. After a median follow-up of 11.5 months (range 3-40 months), 20 pts were still in the study and did not receive any systemic therapy. Nine pts started systemic therapy, and the median time of the primary endpoint was 39.7 months (CI 12.20-62.14 months). No grade 3 or 4 toxicity was recorded.
  
  
  CONCLUSIONS
  Repeated salvage [(18)F]FMCHPET/CT-guided SBRT is well tolerated and could defer the beginning of systemic therapy in selected patients with oligometastatic PCa.
authors.affiliation: Radiation Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. francep24@hotmail.com.|Radiation Oncology, Pisa University Hospital, Via Roma 67, 56126, Pisa, Italy. francep24@hotmail.com.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pasqualetti
authors.affiliation: Radiation Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. markopanichi@gmail.com.
authors.forename: Marco
authors.initials: M
authors.lastname: Panichi
authors.affiliation: Radiation Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. a.sainato@ao-pisa.toscana.it.
authors.forename: Aldo
authors.initials: A
authors.lastname: Sainato
authors.affiliation: Radiation Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. fabrizio.matteucci@gmail.com.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Matteucci
authors.affiliation: Medical Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. lugal71@yahoo.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Galli
authors.affiliation: Radiation Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. paola.cocuzza@gmail.com.
authors.forename: Paola
authors.initials: P
authors.lastname: Cocuzza
authors.affiliation: Radiation Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. patferrazza@gmail.com.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Ferrazza
authors.affiliation: Radiation Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. gabriele.coraggio@gmail.com.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Coraggio
authors.affiliation: Humanitas University, Via Manzoni 113, Rozzano, Milano, 20089, Italy. giuseppe.pasqualetti@gmail.com.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pasqualetti
authors.affiliation: Medical Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. deros.lisa@gmail.com.
authors.forename: Lisa
authors.initials: L
authors.lastname: Derosa
authors.affiliation: Humanitas University, Via Manzoni 113, Rozzano, Milano, 20089, Italy. martinasollini@msn.com.
authors.forename: Martina
authors.initials: M
authors.lastname: Sollini
authors.affiliation: Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, USA. mannellilorenzo@yahoo.it.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Mannelli
authors.affiliation: Radiology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. s.ortori@libero.it.
authors.forename: Simona
authors.initials: S
authors.lastname: Ortori
authors.affiliation: Geriatrics Unit, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. fabio.monzani@med.unipi.it.
authors.forename: Fabio
authors.initials: F
authors.lastname: Monzani
authors.affiliation: Medical Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. s.ricci@ao-pisa.toscana.it.
authors.forename: Sergio
authors.initials: S
authors.lastname: Ricci
authors.affiliation: Radiation Oncology, Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038, Lisboa, Portugal. carlogreco.office@gmail.com.
authors.forename: Carlo
authors.initials: C
authors.lastname: Greco
authors.affiliation: Radiation Oncology, Azienda Ospedaliero Universitaria Pisana, Via Roma 55, 56126, Pisa, Italy. m.fabrini@ao-pisa.toscana.it.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Fabrini
authors.affiliation: Department of Translational Research and New Technologies in Medicine, Regional Center of Nuclear Medicine, University of Pisa, Via Savi 10, 56126, Pisa, Italy. p.erba@med.unipi.it.
authors.forename: Paola Anna
authors.initials: PA
authors.lastname: Erba
mesh_terms: D000368:Aged; D002794:Choline / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry; D003657:Decision Making; D003661:Decision Support Techniques; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D018572:Disease-Free Survival; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D049268:Positron-Emission Tomography; D016016:Proportional Hazards Models; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D016634:Radiosurgery / Q000379:methods*; D016879:Salvage Therapy / Q000379:methods; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D005462:Fluorine Radioisotopes; D017430:Prostate-Specific Antigen; D002794:Choline