title: Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea-induced t-MDS/AML.
abstract: Rapid remission of MDS/AML may be induced with Decitabine; however, significant megakaryocyte expansion and subsequent thrombocytosis may occur. Decitabine-mediated reversion of the MDS to benign ET via hypomethylation of JAK/STAT pathway repressors is one potential mechanism to explain this observed phenomenon.
authors.affiliation: New York University School of Medicine 550 First Avenue New York New York 10010.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Horton
authors.affiliation: Department of Pathology New York University Medical Center 530 First Avenue New York New York 10010.
authors.forename: Arnaldo A
authors.initials: AA
authors.lastname: Arbini
authors.affiliation: Department of Pathology New York University Medical Center 530 First Avenue New York New York 10010.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Perle
authors.affiliation: Hematology Division Department of Medicine New York University Medical Center 550 First Avenue New York New York 10010.
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Raphael
keywords: Acute leukemia; chemotherapy; essential thrombocythemia; hydroxyurea; leukemia cytogenetics; megakaryocyte