title: Laparoscopic Radiofrequency Ablation versus Partial Nephrectomy for cT1a Renal Tumors: Long-Term Outcome of 179 Patients.
abstract: OBJECTIVE
  To compare the long-term functional and oncological results between laparoscopic radiofrequency ablation (LRFA) and laparoscopic partial nephrectomy (LPN) in selected clinical T1a (cT1a) renal tumor patients.
  
  
  METHODS
  We retrospectively analyzed the medical records of patients with cT1a renal tumors who had LRFA or LPN at our institution between February 2006 and February 2015. Student's t test was used to compare the perioperative data between the two groups. Survival analyses were calculated using the Kaplan-Meier method.
  
  
  RESULTS
  A total of 179 patients were included in the study. Patients in the LRFA cohort were significantly older and had higher American Society of Anesthesiologists sore than in the LPN cohort. The LRFA group had a significantly lower mean blood loss than the LPN group (p = 0.03). The percent decrease of GFR in the LRFA group was significantly lower than in the LPN group (p = 0.021). The 5-year overall, cancer-specific and disease-free survival were 93.3 vs. 94.6%, 98.0 vs. 98.5% and 97.1 vs. 97.3%, for LRFA and LPN, respectively (all p value >0.05).
  
  
  CONCLUSIONS
  The excellent perioperative results, long-term functional and oncological outcomes of LRFA confirm that this technique is safe, nephron sparing and oncologically effective for the treatment of cT1a renal tumors.
authors.affiliation: Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
authors.forename: Changwei
authors.initials: C
authors.lastname: Ji
authors.forename: Xiaozhi
authors.initials: X
authors.lastname: Zhao
authors.forename: Shiwei
authors.initials: S
authors.lastname: Zhang
authors.forename: Guangxiang
authors.initials: G
authors.lastname: Liu
authors.forename: Xiaogong
authors.initials: X
authors.lastname: Li
authors.forename: Gutian
authors.initials: G
authors.lastname: Zhang
authors.forename: Andrea
authors.initials: A
authors.lastname: Minervini
authors.forename: Hongqian
authors.initials: H
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017115:Catheter Ablation / Q000379:methods*; D003287:Contrast Media / Q000737:chemistry; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000532:radiotherapy* / Q000601:surgery* / Q000628:therapy*; D010535:Laparoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009392:Nephrectomy / Q000379:methods*; D009399:Nephrons / Q000601:surgery*; D059035:Perioperative Period; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media