title: Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer.
abstract: Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related mortalities worldwide. Platelets play an important and multifaceted role in cancer progression. Elevated mean platelet volume (MPV) detected in peripheral blood has been identified in various types of cancer. In the present study, we investigated the application value of MPV in the prediction of chemotherapy response and prognosis in patients with unresectable gastric cancer. A total of 128 patients with unresectable gastric cancer were included and divided according to the median values of baseline MPV (low MPV: <11.65 or high MPV: ≥11.65). A low baseline MPV level was correlated with reduced metastasis. The results showed that patients with a low baseline level of MPV improved response to chemotherapy. Changes in MPV were associated with therapeutic efficacy. Patients who remained in or were transferred into the low MPV level subgroup following first-line chemotherapy had improved response, compared to those remaining in or being transferred into the high MPV level group. The patients with a higher baseline MPV had decreased progression-free and overall survival ratios. Univariate and multivariate analyses revealed that baseline MPV was a prognostic factor affecting progression-free survival. In conclusion, the results showed that MPV measurements can provide important prognostic information for gastric cancer patients.
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China; Department of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu 215131, P.R. China.
authors.forename: Lian
authors.initials: L
authors.lastname: Lian
authors.affiliation: Department of Radiation Oncology, Lianyungang First People's Hospital, Lianyungang, Jiangsu 222002, P.R. China; The Fourth Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors.forename: You-You
authors.initials: YY
authors.lastname: Xia
authors.affiliation: Department of Radiation Oncology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Chong
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu 215131, P.R. China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Shen
authors.affiliation: Department of General Surgery, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu 215133, P.R. China.
authors.forename: Xiang-Li
authors.initials: XL
authors.lastname: Li
authors.affiliation: Department of General Surgery, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu 215133, P.R. China.
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Han
authors.affiliation: Department of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu 215131, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.
authors.forename: Fei-Ran
authors.initials: FR
authors.lastname: Gong
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China; Jiangsu Institute of Clinical Immunology, Soochow University, Suzhou, Jiangsu 215007, P.R. China; Institute of Medical Biotechnology, Soochow University, Suzhou, Jiangsu 215007, P.R. China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, Jiangsu 215021, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Tao
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China; Jiangsu Institute of Clinical Immunology, Soochow University, Suzhou, Jiangsu 215007, P.R. China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, Jiangsu 215021, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
keywords: chemotherapy; gastric cancer; mean platelet volume; prognosis