title: [Adjuvant Surgery for Initially Unresectable Locally Advanced Pancreatic Cancer following Gemcitabine and S-1 Chemotherapy--A Case Report].
abstract: A man in his 60s was admitted with obstructive jaundice. A hypovascular tumor, 55 mm in diameter, was detected in the pancreas head on imaging. The superior mesenteric vein showed severe stenosis bilaterally and the roots of all branches were invaded by the tumor. The tumor was diagnosed as unresectable pancreatic cancer, and chemotherapy of gemcitabine and S-1 was administered, resulting in a remarkable reduction of the tumor size. Following 7 courses of chemotherapy, a subtotal stomach-preserving pancreatoduodenectomy was carried out. Microscopic examination revealed no residual cancer cells in the resected specimen, indicating that pathological complete remission was obtained. Although some reports suggest that surgical treatment for patients with initially unresectable pancreas cancer who show excellent response to chemotherapy may improve the prognosis, further studies are needed.
authors.affiliation: Dept. of Surgery, Kobe Ekisaikai Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tono
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Manabu
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Hidemine
authors.initials: H
authors.lastname: Senba
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Okubo
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Katayama
authors.forename: Takaaki
authors.initials: T
authors.lastname: Ishii
authors.forename: Koji
authors.initials: K
authors.lastname: Shinozaki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Seiji
authors.initials: S
authors.lastname: Yasuda
authors.forename: Minoru
authors.initials: M
authors.lastname: Ohtsuru
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D016577:Pancreaticoduodenectomy; D005641:Tegafur / Q000008:administration & dosage; D000093542:Gemcitabine
chemical_list: D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine