title: Comparative study of self-expanding metal stent and intraluminal radioactive stent for inoperable esophageal squamous cell carcinoma.
abstract: BACKGROUND
  We compared the effectiveness of self-expanding metal stent alone vs. radioactive stent embedded with 125I seeds implantation insertion in patients of inoperable esophageal squamous cell cancer combined with malignant esophageal stenosis.
  
  
  METHODS
  We studied two groups of patients with stenosis attribute to inoperable esophageal squamous cell carcinoma. Group A had placed self-expanding metal stent alone insertion; group B encountered radioactive stent embedded with 125I seeds. Patients were followed up by monthly home visits or telephone interview. Survival time was analyzed with Kaplan-Meier analysis. Log rank test was used to analyze factors of survival time for all significant differences.
  
  
  RESULTS
  There was no significant difference between the two groups of all baseline characteristics. There was no statistical difference in complications including massive hematemesis, pain more than 1 month, stent migration, and restenosis. Survival time and causes of death such as tumor metastasis, massive hemorrhage, non-tumor-related factors, and restenosis were comparable between the two groups (P>0.05). The medical costs were significantly less in group A than those in group B (P<0.01).
  
  
  CONCLUSIONS
  Radioactive stent embedded with (125)I seeds was not significant in improving survival rate, but showed to increase hospitalization costs compared to self-expandable metal stent alone in treating inoperable esophageal squamous cell carcinoma stricture.
authors.affiliation: Cardiothoracic Surgery Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China. 22tiandong@163.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Tian
authors.affiliation: Cardiothoracic Surgery Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China. 1104501863@qq.com.
authors.forename: Hongying
authors.initials: H
authors.lastname: Wen
authors.affiliation: Cardiothoracic Surgery Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China. fumaoyongmd@126.com.
authors.forename: Maoyong
authors.initials: M
authors.lastname: Fu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000401:mortality; D003131:Combined Modality Therapy; D057186:Comparative Effectiveness Research; D004938:Esophageal Neoplasms / Q000150:complications* / Q000401:mortality; D000077277:Esophageal Squamous Cell Carcinoma; D004940:Esophageal Stenosis / Q000209:etiology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods*; D011446:Prospective Studies; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D000069322:Self Expandable Metallic Stents; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals