title: Permanent draft genome sequence of the probiotic strain Propionibacterium freudenreichii CIRM-BIA 129 (ITG P20).
abstract: Propionibacterium freudenreichii belongs to the class Actinobacteria (Gram positive with a high GC content). This "Generally Recognized As Safe" (GRAS) species is traditionally used as (i) a starter for Swiss-type cheeses where it is responsible for holes and aroma production, (ii) a vitamin B12 and propionic acid producer in white biotechnologies, and (iii) a probiotic for use in humans and animals because of its bifidogenic and anti-inflammatory properties. Until now, only strain CIRM-BIA1T had been sequenced, annotated and become publicly available. Strain CIRM-BIA129 (commercially available as ITG P20) has considerable anti-inflammatory potential. Its gene content was compared to that of CIRM-BIA1 T. This strain contains 2384 genes including 1 ribosomal operon, 45 tRNA and 30 pseudogenes.
authors.affiliation: INRA, UMR 1253, Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France ; AGROCAMPUS OUEST, UMR1253, UMR Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Falentin
authors.affiliation: INRA, UMR 1253, Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France ; AGROCAMPUS OUEST, UMR1253, UMR Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France.
authors.forename: Stéphanie-Marie
authors.initials: SM
authors.lastname: Deutsch
authors.affiliation: INRA, UR1077 Unité Mathématique Informatique et Génome, Jouy-en-Josas, France.
authors.forename: Valentin
authors.initials: V
authors.lastname: Loux
authors.affiliation: INRA, UR1077 Unité Mathématique Informatique et Génome, Jouy-en-Josas, France.
authors.forename: Amal
authors.initials: A
authors.lastname: Hammani
authors.affiliation: INRA, UR1077 Unité Mathématique Informatique et Génome, Jouy-en-Josas, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Buratti
authors.affiliation: INRA, UMR 1253, Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France ; AGROCAMPUS OUEST, UMR1253, UMR Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Parayre
authors.affiliation: INRA, UMR 1253, Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France ; AGROCAMPUS OUEST, UMR1253, UMR Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France.
authors.forename: Victoria
authors.initials: V
authors.lastname: Chuat
authors.affiliation: CEA Genoscope CNRS and université d'Evry, 91 006 Evry, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Barbe
authors.affiliation: CEA Genoscope CNRS and université d'Evry, 91 006 Evry, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Aury
authors.affiliation: INRA, UMR 1253, Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France ; AGROCAMPUS OUEST, UMR1253, UMR Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France.
authors.forename: Gwenaël
authors.initials: G
authors.lastname: Jan
authors.affiliation: INRA, UMR 1253, Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France ; AGROCAMPUS OUEST, UMR1253, UMR Science et Technologie du Lait et de l'Oeuf, 35000 Rennes, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Le Loir
keywords: GRAS; QPS; anti-inflammatory; immunomodulation; probiotic; surface proteins