title: Epithelial-to-mesenchymal transition of tubular epithelial cells in renal fibrosis: a new twist on an old tale.
abstract: Recent publications have questioned whether epithelial-to-mesenchymal transition of tubular epithelial cells is an important contributor to renal fibrosis. Two recent publications describe an intratubular epithelial-to-mesenchymal transition-like program of epithelial cell dedifferentiation that may contribute to the recruitment or proliferation of interstitial myofibroblasts after kidney injury.
authors.affiliation: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Madhav C
authors.initials: MC
authors.lastname: Menon
authors.affiliation: James J. Peters VA Medical Center, Bronx, NY, USA. Electronic address: michael.ross@mssm.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Ross
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000502:physiology; D058750:Epithelial-Mesenchymal Transition; D005355:Fibrosis; D007674:Kidney Diseases / Q000473:pathology*