title: Variation analysis of EXO1 gene in Chinese patients with premature ovarian failure.
abstract: Exonuclease 1 (EXO1) is required for both DNA repair and meiosis. Inactivation of EXO1 gene in mice leads to infertility. This study aimed to investigate whether variants in the EXO1 gene contribute to human premature ovarian failure (POF). The coding region of EXO1 was sequenced in 186 Han Chinese patients with non-syndromic POF. No plausible mutation was detected. The results suggest that mutations in the coding region of EXO1 may not be responsible for POF in Han Chinese women.
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
authors.forename: Shizhen
authors.initials: S
authors.lastname: Su
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Han
authors.affiliation: Biological Sciences, College of Liberal Arts and Science, University of Connecticut, 2131 Hillside Rd, Storrs, CT 06269, USA.
authors.forename: Bowen
authors.initials: B
authors.lastname: Ma
authors.affiliation: Department of Obstetrics and Gynecology, Renji Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Li
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China. Electronic address: shidouzhao@sdu.edu.cn.
authors.forename: Shidou
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China; D004252:DNA Mutational Analysis; D045643:DNA Repair Enzymes / Q000737:chemistry / Q000235:genetics*; D005090:Exodeoxyribonucleases / Q000737:chemistry / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D016649:Primary Ovarian Insufficiency / Q000235:genetics*
chemical_list: C114331:EXO1 protein, human; D005090:Exodeoxyribonucleases; D045643:DNA Repair Enzymes
keywords: EXO1; premature ovarian failure; single-nucleotide polymorphism; variant screening