title: Correlation Between White Matter Lesions and Intelligence Quotient in Patients With Congenital Cytomegalovirus Infection.
abstract: BACKGROUND
  It is well known that congenital cytomegalovirus infection exhibits white matter and other types of lesions in magnetic resonance imaging (MRI), but little is known on the clinical significance of white matter lesions because they are also present in asymptomatic congenital cytomegalovirus infection. We investigated for relationships among white matter lesions, intelligence quotient, and other neurodevelopmental features.
  
  
  METHODS
  Nine children (five boys and four girls; mean age: 87.4 months, range: 63-127 months) with sensorineural hearing loss (five bilateral and four unilateral) had been diagnosed as having congenital cytomegalovirus infection by positive polymerase chain reaction findings of dried umbilical cords. They were evaluated for the presence of autistic features, tested using Wechsler Intelligence Scale for Children-Fourth Edition for intelligence quotient, and underwent brain MRI to measure white matter lesion localization and volume.
  
  
  RESULTS
  At the time of MRI examination (mean age: 69.4 months, range: 19-92 months), white matter lesions were detected in eight of nine patients. Five subjects were diagnosed as having autism spectrum disorders. We observed increased white matter lesion volume was associated with lower intelligence quotient scores (R(2) = 0.533, P = 0.026) but not with autism spectrum disorders.
  
  
  CONCLUSIONS
  In individuals with congenital cytomegalovirus, an increased white matter lesion volume is associated with lower intelligence quotient scores but not with an increased likelihood of autistic behavior.
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. Electronic address: inabay@shinshu-u.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Inaba
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Motobayashi
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishioka
authors.affiliation: Department of Radiology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kaneko
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Yamauchi
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kawasaki
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Shiba
authors.affiliation: Department of Otolaryngology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Shin-ya
authors.initials: SY
authors.lastname: Nishio
authors.affiliation: Department of Otolaryngology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Moteki
authors.affiliation: Department of Otolaryngology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Miyagawa
authors.affiliation: Department of Otolaryngology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takumi
authors.affiliation: Department of Otolaryngology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Usami
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Koike
mesh_terms: D000067877:Autism Spectrum Disorder / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D066127:White Matter / Q000473:pathology*
keywords: autism spectrum disorders; brain magnetic resonance imaging; congenital cytomegalovirus infection; intelligence quotient; white matter lesion