title: Changes in Inflammatory Activity after Glaucoma Filtration Surgery in Children with Chronic Anterior Uveitis.
abstract: OBJECTIVE
  To evaluate changes in inflammatory activity over time in patients with juvenile idiopathic arthritis (JIA)-associated anterior uveitis after two different types of glaucoma surgery.
  
  
  METHODS
  Retrospective analysis of 32 patients with JIA who had trabeculectomy (TE, 21 eyes) or Ahmed glaucoma valve implantation (AGV, 11 eyes). Inflammatory activity and use of anti-inflammatory medication were evaluated 1 year prior to surgery and in the first, third, and fifth years after surgery.
  
  
  RESULTS
  In both groups IOP decreased significantly from pre-surgery to 2 years after surgery (TE, 31.1 ± 6.7 to 12.8 ± 6.1 mmHg, p<0.0001; AGV, 28.5 ± 8.5 to 14.9 ± 6.6 mmHg, p<0.001). In the TE group flare, anterior chamber cells, and uveitis activity decreased significantly after surgery, whereas with AGV there was no sustained reduction of flare.
  
  
  CONCLUSIONS
  The degree of inflammation in JIA-associated uveitis is significantly reduced after trabeculectomy.
authors.affiliation: a Department of Ophthalmology , St. Franziskus-Hospital Muenster , Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Wiese
authors.affiliation: a Department of Ophthalmology , St. Franziskus-Hospital Muenster , Germany.|b Department of Ophthalmology at University of Duisburg-Essen , Germany.
authors.forename: Arnd
authors.initials: A
authors.lastname: Heiligenhaus
authors.affiliation: a Department of Ophthalmology , St. Franziskus-Hospital Muenster , Germany.|b Department of Ophthalmology at University of Duisburg-Essen , Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Heinz
mesh_terms: D000293:Adolescent; D000867:Anterior Chamber / Q000473:pathology; D001171:Arthritis, Juvenile / Q000503:physiopathology*; D002648:Child; D002908:Chronic Disease; D005901:Glaucoma / Q000503:physiopathology / Q000601:surgery*; D020327:Glaucoma Drainage Implants; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000503:physiopathology; D007429:Intraocular Pressure / Q000502:physiology; D010783:Photometry; D012189:Retrospective Studies; D014130:Trabeculectomy; D014606:Uveitis, Anterior / Q000503:physiopathology*; D055815:Young Adult
keywords: Uveitis; glaucoma; inflammation; trabeculectomy