title: Vitamin D Dosing Strategies Among Jordanians With Hypovitaminosis D.
abstract: OBJECTIVE
  To compare between weekly and daily cholecalciferol in patients with hypovitaminosis D and to determine the optimal maintenance dose.
  
  
  METHODS
  Seventy-one volunteers with hypovitaminosis D were randomly assigned to 2 dose regimens: cholecalciferol 50 000 IU weekly for 8 weeks, then 50 000 IU monthly for 2 months (group A) and 7000 IU daily for 8 weeks, then 12 500 IU weekly for 2 months (group B). Cholecalciferol was stopped for 2 months and reintroduced as 50 000 IU bimonthly for group A and 50 000 IU monthly for group B.
  
  
  RESULTS
  Two months after therapy, the mean serum 25-hydroxyvitamin D (25(OH)D) level increased from 11.4 to 51.2 ng/mL and from 11.7 to 44.9 ng/mL in groups A and B, respectively ( P = .065). The levels of 25(OH)D declined similarly in both groups during maintenance and after holding therapy. After resuming cholecalciferol, 25(OH)D levels increased to 33.8 and 28.8 ng/mL in groups A and B, respectively ( P = .027). There was a negative correlation between serum 25(OH)D levels and body mass index (BMI; P = .040).
  
  
  CONCLUSIONS
  Timing and frequency of the dosing (daily vs weekly) have no effect on the rise in serum 25(OH)D levels as long as the accumulative dose of cholecalciferol is similar. Cholecalciferol 50 000 IU bimonthly is required to maintain sufficient 25(OH)D levels.
authors.affiliation: 1 The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), The University of Jordan, Amman, Jordan.
authors.forename: Nahla
authors.initials: N
authors.lastname: Khawaja
authors.affiliation: 1 The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), The University of Jordan, Amman, Jordan.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Liswi
authors.affiliation: 1 The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), The University of Jordan, Amman, Jordan.|2 Department of Pathology, Microbiology and Forensic Medicine, The University of Jordan, Amman, Jordan.
authors.forename: Mohammed
authors.initials: M
authors.lastname: El-Khateeb
authors.affiliation: 1 The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), The University of Jordan, Amman, Jordan.
authors.forename: Dana
authors.initials: D
authors.lastname: Hyassat
authors.affiliation: 1 The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), The University of Jordan, Amman, Jordan.
authors.forename: Dalila
authors.initials: D
authors.lastname: Bajawi
authors.affiliation: 1 The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), The University of Jordan, Amman, Jordan.
authors.forename: Mayada
authors.initials: M
authors.lastname: Elmohtaseb
authors.affiliation: 1 The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), The University of Jordan, Amman, Jordan.
authors.forename: Hussein
authors.initials: H
authors.lastname: Alkhateeb
authors.affiliation: 1 The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), The University of Jordan, Amman, Jordan.
authors.forename: Kamel
authors.initials: K
authors.lastname: Ajlouni
mesh_terms: D000328:Adult; D002762:Cholecalciferol / Q000008:administration & dosage*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007597:Jordan / Q000453:epidemiology; D008297:Male; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D
keywords: Jordan; cholecalciferol; hypovitaminosis D; therapy