title: The Associations Between Increasing Degrees of HOMA-IR and Measurements of Adiposity Among Euglycemic U.S. Adults.
abstract: BACKGROUND
  The purpose of this study was to examine the associations between increasing degrees of insulin resistance (using the homeostatic model assessment of insulin resistance [HOMA-IR]) and two measures of adiposity in a nationally representative sample of euglycemic U.S. adults.
  
  
  METHODS
  Sample included adult participants (≥ 20 years of age) [N = 1586 (body mass index, BMI model), N = 1577 (waist circumference, WC model)] from the 1999-2004 National Health and Nutrition Examination Survey (NHANES). HOMA-IR was categorized into quartiles. BMI and WC were examined continuously as the dependent variables.
  
  
  RESULTS
  Following adjustment for covariates, those with HOMA-IR values in the second, third, and fourth quartiles had significantly higher BMIs (P < 0.001) compared with subjects in the first quartile. In the model using WC, significantly higher WCs were found in subjects in the second, third, and fourth quartiles of HOMA-IR (P < 0.001) compared with those in the first quartile. A significant moderate correlation was found between HOMA-IR and BMI (R(2) = 0.4171, P < 0.001), as well as HOMA-IR and WC (R(2) = 0.4826, P < 0.001).
  
  
  CONCLUSIONS
  Having a higher HOMA-IR value is associated with higher BMI and WC values in euglycemic subjects.
authors.affiliation: 1 Department of Kinesiology, Recreation, and Sport Studies, University of Tennessee , Knoxville, Tennessee.
authors.forename: William R
authors.initials: WR
authors.lastname: Boyer
authors.affiliation: 2 Department of Public Health, University of North Florida , Jacksonville, Florida.
authors.forename: Tammie M
authors.initials: TM
authors.lastname: Johnson
authors.affiliation: 1 Department of Kinesiology, Recreation, and Sport Studies, University of Tennessee , Knoxville, Tennessee.
authors.forename: Eugene C
authors.initials: EC
authors.lastname: Fitzhugh
authors.affiliation: 3 Department of Clinical and Applied Movement Sciences, University of North Florida , Jacksonville, Florida.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Richardson
authors.affiliation: 3 Department of Clinical and Applied Movement Sciences, University of North Florida , Jacksonville, Florida.
authors.forename: James R
authors.initials: JR
authors.lastname: Churilla
mesh_terms: D050154:Adiposity; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin