title: Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoblasts and Adipocytes and its Role in Treatment of Osteoporosis.
abstract: Osteoporosis is a systemic metabolic bone disorder characterized by a decrease in bone mass and degradation of the bone microstructure, leaving bones that are fragile and prone to fracture. Most osteoporosis treatments improve symptoms, but to date there is no quick and effective therapy. Bone marrow mesenchymal stem cells (BMMSCs) have pluripotent potential. In adults, BMMSCs differentiate mainly into osteoblasts and adipocytes in the skeleton. However, if this differentiation is unbalanced, it may lead to a decrease in bone mass. If the number of adipocyte cells increases and that of osteoblast cells decreases, osteoporosis can result. A variety of hormones and cytokines play an important role in the regulation of BMMSCs bidirectional differentiation. Therefore, a greater understanding of the regulation mechanism of BMMSC differentiation may provide new methods to prevent and treat osteoporosis. In addition, autologous, allogeneic BMMSCs or genetically modified BMMSC transplantation can effectively increase bone mass and density, increase bone mechanical strength, correct the imbalance in bone metabolism, and increase bone formation, and is expected to provide a new strategy and method for the treatment of osteoporosis.
authors.affiliation: Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China (mainland).
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China (mainland).
authors.forename: Haoye
authors.initials: H
authors.lastname: Meng
authors.affiliation: Department of Orthopedics, Urumqi General Hospital of Lanzhou Military Command, Urumqi, Xinjiang, China (mainland).
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China (mainland).
authors.forename: Chenyang
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China (mainland).
authors.forename: Jing
authors.initials: J
authors.lastname: Peng
authors.affiliation: Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China (mainland).
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010006:Osteoblasts / Q000166:cytology*; D010024:Osteoporosis / Q000628:therapy*