title: A Circadian and Cardiac Intraocular Pressure Sensor for Smart Implantable Lens.
abstract: This paper presents a new system to measure the Intraocular Pressure (IOP) with very high accuracy (0.036 mbar) used for monitoring glaucoma. The system not only monitors the daily variation of the IOP (circadian IOP), but also allows to perform an spectral analysis of the pressure signal generated by the heartbeat (cardiac IOP). The system comprises a piezoresistive pressure sensor, an application-specific integrated circuit (ASIC) to read out the sensor data and an external reader installed on customized glasses. The ASIC readout electronics combines chopping modulation with correlated double sampling (CDS) in order to eliminate both the amplifier offset and the chopper ripple at the sampling frequency. In addition, programmable current sources are used to compensate for the atmospheric pressure ( 800-1200 mbar ) and the circadian component (± 7 mbar) thus allowing to read out the very weak cardiac signals (± 1.6 mbar) with a maximum accuracy of 0.036 mbar.
authors.forename: Achille
authors.initials: A
authors.lastname: Donida
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Dato
authors.forename: Paolo
authors.initials: P
authors.lastname: Cunzolo
authors.forename: Marco
authors.initials: M
authors.lastname: Sala
authors.forename: Filippo
authors.initials: F
authors.lastname: Piffaretti
authors.forename: Paolo
authors.initials: P
authors.lastname: Orsatti
authors.forename: Diego
authors.initials: D
authors.lastname: Barrettino
mesh_terms: D015374:Biosensing Techniques; D002940:Circadian Rhythm; D005901:Glaucoma / Q000175:diagnosis; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D007910:Lenses, Intraocular; D063731:Mobile Applications; D018670:Monitoring, Ambulatory / Q000295:instrumentation / Q000379:methods; D058998:Remote Sensing Technology / Q000295:instrumentation*; D014065:Tonometry, Ocular / Q000295:instrumentation* / Q000379:methods