title: Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists.
abstract: A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Micheli
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Cremonesi
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Semeraro
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Tarsi
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Tomelleri
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Cavanni
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Oliosi
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Perdonà
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Sava
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Zonzini
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Aldo
authors.initials: A
authors.lastname: Feriani
authors.affiliation: Aptuit s.r.l, Via Fleming 4, 37135 Verona, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Braggio
authors.affiliation: Indivior Inc, The Fairfax Building, 10710 Midlothian Turnpike, Suite 430, Richmond, VA 23235, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Heidbreder
mesh_terms: D000818:Animals; D001665:Binding Sites; D065127:Dopamine D2 Receptor Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D006207:Half-Life; D062105:Molecular Docking Simulation; D009025:Morpholines / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D017434:Protein Structure, Tertiary; D051381:Rats; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D065127:Dopamine D2 Receptor Antagonists; D009025:Morpholines; D050637:Receptors, Dopamine D3; C037574:morpholine
keywords: 7-TM; Antagonist; DA D3 receptor; Dopamine; Morpholine