title: Adipokines, cytokines and body fat stores in hepatitis C virus liver steatosis.
abstract: OBJECTIVE
  To identify patients with or without liver steatosis and its severity in treatment-naïve patients affected by hepatitis C virus (HCV) infection.
  
  
  METHODS
  We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body (by densitometry), hormones [insulin, homeostatic model assessment (HOMA)], adipokines (resistin, adiponectin, leptin), and cytokines (tumor necrosis factor α, interleukin-6).
  
  
  RESULTS
  Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunk fat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and resistin.
  
  
  CONCLUSIONS
  Steatosis in HCV infection is common (67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines.
authors.affiliation: Emilio González-Reimers, Javier López-Prieto, Geraldine Quintero-Platt, Ricardo Pelazas-González, M Remedios Alemán-Valls, Onán Pérez-Hernández, M José de-la-Vega-Prieto, M Angeles Gómez-Rodríguez, Candelaria Martín-González, Francisco Santolaria-Fernández, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, 38320 Canary Islands, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: González-Reimers
authors.affiliation: Emilio González-Reimers, Javier López-Prieto, Geraldine Quintero-Platt, Ricardo Pelazas-González, M Remedios Alemán-Valls, Onán Pérez-Hernández, M José de-la-Vega-Prieto, M Angeles Gómez-Rodríguez, Candelaria Martín-González, Francisco Santolaria-Fernández, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, 38320 Canary Islands, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: López-Prieto
authors.affiliation: Emilio González-Reimers, Javier López-Prieto, Geraldine Quintero-Platt, Ricardo Pelazas-González, M Remedios Alemán-Valls, Onán Pérez-Hernández, M José de-la-Vega-Prieto, M Angeles Gómez-Rodríguez, Candelaria Martín-González, Francisco Santolaria-Fernández, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, 38320 Canary Islands, Spain.
authors.forename: Geraldine
authors.initials: G
authors.lastname: Quintero-Platt
authors.affiliation: Emilio González-Reimers, Javier López-Prieto, Geraldine Quintero-Platt, Ricardo Pelazas-González, M Remedios Alemán-Valls, Onán Pérez-Hernández, M José de-la-Vega-Prieto, M Angeles Gómez-Rodríguez, Candelaria Martín-González, Francisco Santolaria-Fernández, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, 38320 Canary Islands, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pelazas-González
authors.affiliation: Emilio González-Reimers, Javier López-Prieto, Geraldine Quintero-Platt, Ricardo Pelazas-González, M Remedios Alemán-Valls, Onán Pérez-Hernández, M José de-la-Vega-Prieto, M Angeles Gómez-Rodríguez, Candelaria Martín-González, Francisco Santolaria-Fernández, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, 38320 Canary Islands, Spain.
authors.forename: M Remedios
authors.initials: MR
authors.lastname: Alemán-Valls
authors.affiliation: Emilio González-Reimers, Javier López-Prieto, Geraldine Quintero-Platt, Ricardo Pelazas-González, M Remedios Alemán-Valls, Onán Pérez-Hernández, M José de-la-Vega-Prieto, M Angeles Gómez-Rodríguez, Candelaria Martín-González, Francisco Santolaria-Fernández, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, 38320 Canary Islands, Spain.
authors.forename: Onán
authors.initials: O
authors.lastname: Pérez-Hernández
authors.affiliation: Emilio González-Reimers, Javier López-Prieto, Geraldine Quintero-Platt, Ricardo Pelazas-González, M Remedios Alemán-Valls, Onán Pérez-Hernández, M José de-la-Vega-Prieto, M Angeles Gómez-Rodríguez, Candelaria Martín-González, Francisco Santolaria-Fernández, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, 38320 Canary Islands, Spain.
authors.forename: M José
authors.initials: MJ
authors.lastname: de-la-Vega-Prieto
authors.affiliation: Emilio González-Reimers, Javier López-Prieto, Geraldine Quintero-Platt, Ricardo Pelazas-González, M Remedios Alemán-Valls, Onán Pérez-Hernández, M José de-la-Vega-Prieto, M Angeles Gómez-Rodríguez, Candelaria Martín-González, Francisco Santolaria-Fernández, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, 38320 Canary Islands, Spain.
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Gómez-Rodríguez
authors.affiliation: Emilio González-Reimers, Javier López-Prieto, Geraldine Quintero-Platt, Ricardo Pelazas-González, M Remedios Alemán-Valls, Onán Pérez-Hernández, M José de-la-Vega-Prieto, M Angeles Gómez-Rodríguez, Candelaria Martín-González, Francisco Santolaria-Fernández, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, 38320 Canary Islands, Spain.
authors.forename: Candelaria
authors.initials: C
authors.lastname: Martín-González
authors.affiliation: Emilio González-Reimers, Javier López-Prieto, Geraldine Quintero-Platt, Ricardo Pelazas-González, M Remedios Alemán-Valls, Onán Pérez-Hernández, M José de-la-Vega-Prieto, M Angeles Gómez-Rodríguez, Candelaria Martín-González, Francisco Santolaria-Fernández, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, 38320 Canary Islands, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Santolaria-Fernández
keywords: Adiponectin; Hepatitis C virus; Insulin resistance; Leptin; Liver steatosis; Proinflammatory cytokines; Resistin