title: Biological activities of unique isoflavones prepared from Apios americana Medik.
abstract: Four unique isoflavone aglycones (barpisoflavone A (1), 2'-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1-4. The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities.
authors.affiliation: a Department of Food and Nutrition , Japan Women's University , Tokyo , Japan.
authors.forename: Haruna
authors.initials: H
authors.lastname: Kaneta
authors.affiliation: a Department of Food and Nutrition , Japan Women's University , Tokyo , Japan.
authors.forename: Mina
authors.initials: M
authors.lastname: Koda
authors.affiliation: b Faculty of Science and Technology, Department of Biosciences and Informatics , Keio University , Yokohama , Japan.
authors.forename: Shun
authors.initials: S
authors.lastname: Saito
authors.affiliation: b Faculty of Science and Technology, Department of Biosciences and Informatics , Keio University , Yokohama , Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Imoto
authors.affiliation: c Microbial Chemistry Research Foundation Institute of Microbial Chemistry (BIKAKEN) , Numazu , Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawada
authors.affiliation: c Microbial Chemistry Research Foundation Institute of Microbial Chemistry (BIKAKEN) , Numazu , Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yamazaki
authors.affiliation: c Microbial Chemistry Research Foundation Institute of Microbial Chemistry (BIKAKEN) , Numazu , Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Momose
authors.affiliation: a Department of Food and Nutrition , Japan Women's University , Tokyo , Japan.
authors.forename: Kazuoshi
authors.initials: K
authors.lastname: Shindo
mesh_terms: D007887:Fabaceae / Q000737:chemistry*; D007529:Isoflavones / Q000494:pharmacology*
chemical_list: D007529:Isoflavones
keywords: Apios americana Medik; antioxidant activity; estrogen agonistic activity; isoflavone; α-glucosidase inhibitory activity