title: New composite materials based on alginate and hydroxyapatite as potential carriers for ascorbic acid.
abstract: The purpose of this article was to obtain prolonged drug release systems in which the drug (ascorbic acid) to reach intact the target area in an environment that is able to control the administration of the active component by chemical or physiological pathways. As support for drug, it was used a material based on calcium phosphate - hydroxyapatite and a natural polymer - alginate, since it is one of the most investigated composite materials for medical applications due to its positive response to biological testing: bioactivity, biocompatibility and osteoconductivity. Three composites with different ratios between alginate and hydroxyapatite were obtained: (a) Alg/HA/AA 1:1 (the mass ratio between Alg and HA being of 1:1), (b) Alg/HA/AA 1:3 (Alg:HA mass ratio of 1:3) and (c) Alg/HA/AA 3:1 (Alg:HA mass ratio of 3:1). The synthesized materials were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and to observe the drug release process, UV-vis spectroscopy.
authors.affiliation: POLITEHNICA University of Bucharest, Faculty of Applied Chemistry and Material Science, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania. Electronic address: andreiailie@gmail.com.
authors.forename: Andreia
authors.initials: A
authors.lastname: Ilie
authors.affiliation: POLITEHNICA University of Bucharest, Faculty of Applied Chemistry and Material Science, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Ghiţulică
authors.affiliation: POLITEHNICA University of Bucharest, Faculty of Applied Chemistry and Material Science, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Andronescu
authors.affiliation: POLITEHNICA University of Bucharest, Faculty of Applied Chemistry and Material Science, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.
authors.forename: Andrei
authors.initials: A
authors.lastname: Cucuruz
authors.affiliation: POLITEHNICA University of Bucharest, Faculty of Applied Chemistry and Material Science, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.
authors.forename: Anton
authors.initials: A
authors.lastname: Ficai
mesh_terms: D000464:Alginates / Q000737:chemistry*; D001205:Ascorbic Acid / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration / Q000187:drug effects; D002130:Calcium Phosphates / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D017886:Durapatite / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008422:Materials Testing / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D004337:Drug Carriers; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D017886:Durapatite; C020243:calcium phosphate; D001205:Ascorbic Acid
keywords: Ascorbic acid; Biocompatibility; Composite materials; Hydroxyapatit; Sodium alginate