title: Orthobiologics in Foot and Ankle Surgery.
abstract: Exploration into the molecular aspects of the healing process has led to the development of autologous and recombinant biologic agents. These products, collectively known as orthobiologics, have the potential to optimize favorable outcomes with respect to bone and soft-tissue restoration and to maximize the natural healing response. These orthobiologics include platelet-derived growth factor, bone morphogenetic proteins, and platelet-rich plasma. Although the usefulness of these growth factors is well described in various fields of surgery, few data exist to support or oppose the specific application of growth factors in foot and ankle surgery.
authors.affiliation: From Rutgers New Jersey Medical School, Department of Orthopedics, Newark, NJ.
authors.forename: Sheldon S
authors.initials: SS
authors.lastname: Lin
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Montemurro
authors.forename: Ethan S
authors.initials: ES
authors.lastname: Krell
mesh_terms: D000125:Achilles Tendon / Q000187:drug effects; D000842:Ankle / Q000601:surgery*; D055419:Bone Morphogenetic Protein 7 / Q000627:therapeutic use; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects; D005528:Foot / Q000601:surgery*; D006801:Humans; D019637:Orthopedic Procedures / Q000379:methods; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use; D053657:Platelet-Rich Plasma; D052256:Tendinopathy / Q000188:drug therapy; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D010982:Platelet-Derived Growth Factor