title: Neural Function Before and After Mindfulness-Based Cognitive Therapy in Anxious Adolescents at Risk for Developing Bipolar Disorder.
abstract: We sought to evaluate the neurophysiology of mindfulness-based cognitive therapy for children (MBCT-C) in youth with generalized, social, and/or separation anxiety disorder who were at risk for developing bipolar disorder.
  
  
  
  Nine youth (mean age: 13 ± 2 years) with a generalized, social, and/or separation anxiety disorder and a parent with bipolar disorder completed functional magnetic resonance imaging (fMRI) while performing a continuous processing task with emotional and neutral distractors (CPT-END) prior to and following 12 weeks of MBCT-C.
  
  
  
  MBCT-C was associated with increases in activation of the bilateral insula, lentiform nucleus, and thalamus, as well as the left anterior cingulate while viewing emotional stimuli during the CPT-END, and decreases in anxiety were correlated with change in activation in the bilateral insula and anterior cingulate during the viewing of emotional stimuli (p < 0.05, uncorrected; p < 0.005 corrected; cluster size, 37 voxels).
  
  
  
  MBCT-C treatment in anxious youth with a familial history of bipolar disorder is associated with increased activation of brain structures that subserve interoception and the processing of internal stimuli-functions that are ostensibly improved by this treatment.
authors.affiliation: 1 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati , College of Medicine, Cincinnati, Ohio.|2 Cincinnati Children's Hospital Medical Center , Department of Psychiatry, Cincinnati, Ohio.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Strawn
authors.affiliation: 3 Department of Family and Community Medicine, University of Cincinnati, Center for Imaging Research, University of Cincinnati , Cincinnati, Ohio.
authors.forename: Sian
authors.initials: S
authors.lastname: Cotton
authors.affiliation: 3 Department of Family and Community Medicine, University of Cincinnati, Center for Imaging Research, University of Cincinnati , Cincinnati, Ohio.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Luberto
authors.affiliation: 1 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati , College of Medicine, Cincinnati, Ohio.
authors.forename: L Rodrigo
authors.initials: LR
authors.lastname: Patino
authors.affiliation: 1 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati , College of Medicine, Cincinnati, Ohio.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Stahl
authors.affiliation: 1 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati , College of Medicine, Cincinnati, Ohio.
authors.forename: Wade A
authors.initials: WA
authors.lastname: Weber
authors.affiliation: 3 Department of Family and Community Medicine, University of Cincinnati, Center for Imaging Research, University of Cincinnati , Cincinnati, Ohio.
authors.forename: James C
authors.initials: JC
authors.lastname: Eliassen
authors.affiliation: 1 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati , College of Medicine, Cincinnati, Ohio.
authors.forename: Richard
authors.initials: R
authors.lastname: Sears
authors.affiliation: 1 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati , College of Medicine, Cincinnati, Ohio.|2 Cincinnati Children's Hospital Medical Center , Department of Psychiatry, Cincinnati, Ohio.
authors.forename: Melissa P
authors.initials: MP
authors.lastname: DelBello
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000523:psychology / Q000628:therapy*; D001714:Bipolar Disorder / Q000517:prevention & control*; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D064866:Mindfulness / Q000379:methods*; D009483:Neuropsychological Tests; D012307:Risk Factors; D016896:Treatment Outcome