title: Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow.
abstract: Plasma therapy consists in bringing to a patient in need - in general suffering a severe, resistant to current therapy, and even lethal infection - plasma or specific, fractioned, antibodies, along with other immunoglobulins and possibly healing factors that can be obtained from immunized blood donors; donors (voluntary and benevolent) can be either actively immunized individuals or convalescent persons. Plasma therapy has been used since the Spanish flu in 1917-1918, and regularly then when viral epidemics threatened vulnerable populations, the last reported occurrence being the 2013-2015 Ebola virus outbreak in West Africa. The precise action mechanism of plasma therapy is not fully delineated as it may function beyond purified, neutralizing antibodies.
authors.affiliation: Faculté de médecine de Saint-Étienne, université de Lyon, 42023 Saint-Étienne, France; Institut national de la transfusion sanguine, 75015 Paris, France. Electronic address: ogarraud@ints.fr.
authors.forename: O
authors.initials: O
authors.lastname: Garraud
authors.affiliation: Hôpital Cochin, Assistance publique des Hôpitaux de Paris, 75005 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Heshmati
authors.affiliation: Faculté de médecine de Saint-Étienne, université de Lyon, 42023 Saint-Étienne, France; Laboratoire des agents infectieux et d'hygiène, CHU de Saint-Étienne, 42055 Saint-Étienne, France.
authors.forename: B
authors.initials: B
authors.lastname: Pozzetto
authors.affiliation: Groupe Necker-Enfants malades, Assistance publique des Hôpitaux de Paris, 75015, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Lefrere
authors.affiliation: Hôpital Tenon, Assistance publique des Hôpitaux de Paris, 75020 Paris, France; Université Pierre-et-Marie-Curie-Paris 6, 75005 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Girot
authors.affiliation: Centre de transfusion sanguine des armées, 92140 Clamart, France.
authors.forename: A
authors.initials: A
authors.lastname: Saillol
authors.affiliation: Institut national de la transfusion sanguine, 75015 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Laperche
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000097:blood / Q000627:therapeutic use; D003289:Convalescence; D004196:Disease Outbreaks; D005544:Forecasting; D006801:Humans; D007116:Immunization, Passive / Q000379:methods* / Q000639:trends; D007239:Infections / Q000628:therapy*; D010949:Plasma / Q000276:immunology; D014777:Virus Diseases / Q000453:epidemiology / Q000628:therapy
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral
keywords: Anticorps neutralisants; Convalescent plasma; Ebolavirus; Ebolavirus infection; Infectious disease; Maladies infectieuses; Neutralizing antibodies; Plasma convalescent; Plasma therapy; Plasma thérapeutique; Plasmathérapie; Therapeutic plasma; Transfusion