title: Interleukin-1B 31 C>T polymorphism combined with Helicobacter pylori-modified gastric cancer susceptibility: evidence from 37 studies.
abstract: Gastric cancer is one of the most common malignancies worldwide. Interleukin-1-beta (IL-1β) is a pro-inflammatory cytokine and potent inhibitor of gastric acid secretion. Some studies provided evidence of the association between IL-1B 31 polymorphism and gastric cancer risk while other studies did not. Therefore, we conducted a comprehensive meta-analysis to reassess the association. A systematic literature search of the PubMed and EMBASE databases identified 37 studies with 6108 cases and 8980 controls for this meta-analysis. The crude odd ratios (ORs) and the 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Meta-regression was used to determine the major source of heterogeneity across the studies. The pooled analysis did not suggest the significant association of IL-1B 31 C>T polymorphism with gastric cancer risk. Stratified analysis was performed by ethnicity, source of control, genotype method, and indicated a significantly increased gastric cancer risk associated with IL-1B 31T variant in the population-based subgroup (heterozygous model: OR = 1.22, 95% CI = 1.03-1.45). Moreover, stratified analysis by Helicobacter pylori infection status indicated that IL-1B 31 polymorphism increased gastric cancer risk in infection-positive subgroup (homozygous model: OR = 1.35, 95% CI = 1.02-1.78; heterozygous model: OR = 1.31, 95% CI = 1.04-1.66; recessive model: OR = 1.29, 95% CI = 1.04-1.61). The study suggested that IL-1B 31 polymorphism might confer susceptibility to gastric cancer in the presence of H. pylori infection, indicating a gene-environment interaction in gastric carcinogenesis.
authors.affiliation: Department of Laboratory Medicine, Jinhua Central Hospital, Jinhua, Zhejiang, China.
authors.forename: Hua-Yong
authors.initials: HY
authors.lastname: Ying
authors.affiliation: Department of Laboratory Medicine, Jinhua People's Hospital, Jinhua, Zhejiang, China.
authors.forename: Bei-Wei
authors.initials: BW
authors.lastname: Yu
authors.affiliation: The Fifth Medical Team, Xinjiang Uygur Autonomous Region Corps of Chinese People's Armed Police Forces, Xinjiang, China.
authors.forename: Zong
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Laboratory Medicine, Jinhua Woman & Children Health Hospital, Jinhua, Zhejiang, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Yang
authors.affiliation: Department of Laboratory Medicine, Jinhua Central Hospital, Jinhua, Zhejiang, China.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Bo
authors.affiliation: Department of Laboratory Medicine, Jinhua Central Hospital, Jinhua, Zhejiang, China.
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Shan
authors.affiliation: Department of Laboratory Medicine, Jinhua People's Hospital, Jinhua, Zhejiang, China.
authors.forename: Hui-Jiao
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, Jinhua Central Hospital, Jinhua, Zhejiang, China.
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Zhu
authors.affiliation: School of Humanities and Social Science, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Wu
mesh_terms: D016022:Case-Control Studies; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000235:genetics* / Q000382:microbiology; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology
chemical_list: D053583:Interleukin-1beta
keywords: gastric cancer; interleukin-1β; meta-analysis; polymorphism