title: Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro.
abstract: In demyelinating diseases such as multiple sclerosis, one of the treatment strategies includes remyelination using oligodendrocyte precursor cells (OPC). Catalpol, the extract of radix rehmanniae, is neuroprotective. Using an OPC culture model, we showed that 10 μM catalpol promotes OPC proliferation, cell migration and differentiation into mature oligodendrocytes. The 10 μM catalpol displayed stronger effects on OPCs migration and oligodendrocyte differentiation. These results suggest that catalpol has a potential role in promoting remyelination in demyelinating diseases, and is of therapeutic interest.
authors.affiliation: Department of Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University Beijing, China.
authors.forename: Chun-Xiao
authors.initials: CX
authors.lastname: Yuan
authors.affiliation: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary Canada.
authors.forename: Takho
authors.initials: T
authors.lastname: Chu
authors.affiliation: Laboratory of Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Laboratory of Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University Beijing, China.
authors.forename: Hao-Wen
authors.initials: HW
authors.lastname: Li
authors.affiliation: Laboratory of Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University Beijing, China.
authors.forename: Ya-Jie
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: Laboratory of Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical UniversityBeijing, China; China National Clinical Research Center for Neurological DiseasesBeijing, China; Center of Stroke, Beijing Institute for Brain DisordersBeijing, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular DiseaseBeijing, China.
authors.forename: An-Chen
authors.initials: AC
authors.lastname: Guo
authors.affiliation: Department of Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University Beijing, China.
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Fan
keywords: Oligodendrocytes precursor cell; catalpol; differentiation; proliferation