title: Application of SonoVue combined with three-dimensional color power angiography in the diagnosis and prognosis evaluation of intrauterine adhesion.
abstract: OBJECTIVE
  To investigate the significance of the related indexes of three-dimensional color power angiography (3D-CPA) combined with SonoVue angiography in the diagnosis and prognosis evaluation of intrauterine adhesion (IUA).
  
  
  METHODS
  The accuracy, sensitivity, and specificity were evaluated between 3D-TVS and hysteroscopy. Endometrial thickness, volume (V), mean gray value (MG), vascularization index (VI), flow index (FI), vascularization flow index (VFI), and other related indexes before and after the angiography were compared. According to the hysteroscopy findings, the patients were divided into three groups: mild, medium, and severe. The endometrial thickness at 3 months postoperatively and the pregnancy rates at 1 year postoperatively were compared.
  
  
  RESULTS
  Compared with the hysteroscopy, sensitivity: 0.970 (0.021), specificity: 0.667 (0.086), (the values inside the bracket were the standard error), positive likelihood ratio: 2.909, negative likelihood ratio: 0.045. There was a significant difference in endometrial thickness and V between the three groups (P<0.05), and there was a significant difference in MG, VI, FI, and VFI between the mild and severe group (P>0.05). During intravenous injection of SonoVue, the blood flow of each group increased (P<0.001), and the VI, FI, and VFI of each group were significantly different (P<0.05). Compared with the preoperative values, the endometrial thickness, V, MG, VI, FI, and VFI significantly changed at 3 months postoperatively (P<0.05). The mild group and high VI group had a higher pregnancy success rate at one year postoperatively.
  
  
  CONCLUSIONS
  3D-CPA can indirectly diagnose IUA, and may play an important role in prognosis assessment.
authors.affiliation: Reproductive Medical Center, Obstetrics and Gynecology of Navy PLA General Hospital, Beijing 100048, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yan
authors.affiliation: Reproductive Medical Center, Obstetrics and Gynecology of Navy PLA General Hospital, Beijing 100048, China. Electronic address: aimingwangcn@163.com.
authors.forename: Aiming
authors.initials: A
authors.lastname: Wang
authors.affiliation: Reproductive Medical Center, Obstetrics and Gynecology of Navy PLA General Hospital, Beijing 100048, China.
authors.forename: Ruifang
authors.initials: R
authors.lastname: Bai
authors.affiliation: Reproductive Medical Center, Obstetrics and Gynecology of Navy PLA General Hospital, Beijing 100048, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shang
authors.affiliation: Reproductive Medical Center, Obstetrics and Gynecology of Navy PLA General Hospital, Beijing 100048, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Reproductive Medical Center, Obstetrics and Gynecology of Navy PLA General Hospital, Beijing 100048, China.
authors.forename: Weizhou
authors.initials: W
authors.lastname: Wang
authors.affiliation: Reproductive Medical Center, Obstetrics and Gynecology of Navy PLA General Hospital, Beijing 100048, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
mesh_terms: D000328:Adult; D000792:Angiography / Q000379:methods*; D004717:Endometrium / Q000098:blood supply / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D015907:Hysteroscopy / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008875:Middle Aged; D010743:Phospholipids; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D012039:Regional Blood Flow; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D000267:Tissue Adhesions / Q000000981:diagnostic imaging; D014591:Uterine Diseases / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride
keywords: Endometrial blood flow; Intrauterine adhesions; SonoVue; Three-dimensional color power angiography (3D-CPA)