title: The role of epidermal sphingolipids in dermatologic diseases.
abstract: Sphingolipids, a group of lipids containing the sphingoid base, have both structural and biological functions in human epidermis. Ceramides, as a part of extracellular lipids in the stratum corneum, are important elements of the skin barrier and are involved in the prevention of transepidermal water loss. In addition, ceramides regulate such processes as proliferation, differentiation and apoptosis of keratinocytes. Another important sphingolipid, sphingosine-1-phosphate (S1P), inhibits proliferation and induces differentiation of keratinocytes. A recent clinical study of the efficacy and safety of ponesimod (a selective modulator of the S1P receptor 1) suggested that sphingolipid metabolism may become a new target for the pharmacological treatment of psoriasis. The role of sphingolipids in some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses was summarized in this article.
authors.affiliation: Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1B, 02-097, Warsaw, Poland. sonia.borodzicz@onet.pl.
authors.forename: Sonia
authors.initials: S
authors.lastname: Borodzicz
authors.affiliation: Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008, Warsaw, Poland. lidiarudnicka@gmail.com.
authors.forename: Lidia
authors.initials: L
authors.lastname: Rudnicka
authors.affiliation: Department of Experimental and Clinical Pharmacology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1B, 02-097, Warsaw, Poland. dmirowska@wum.edu.pl.
authors.forename: Dagmara
authors.initials: D
authors.lastname: Mirowska-Guzel
authors.affiliation: Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1B, 02-097, Warsaw, Poland. agnieszka.cudnoch@wum.edu.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Cudnoch-Jedrzejewska
mesh_terms: D004817:Epidermis / Q000378:metabolism*; D006801:Humans; D012871:Skin Diseases / Q000378:metabolism*; D013107:Sphingolipids / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*
chemical_list: D013107:Sphingolipids