title: The impact of acute bouts of exercise on circulating cardiac natriuretic peptide and left ventricular function in untrained healthy young subjects.
abstract: BACKGROUND
  To examine the impact of a single bout of exercise on cardiac function and the blood level of brain natriuretic peptide (BNP) in healthy subjects.
  
  
  METHODS
  Thirty untrained, healthy young (aged between 20 and 29 years) volunteers (15 men and 15 women) were prospectively recruited. The plasma N-terminal pro-B-type BNP (NT-proBNP) level was checked, cardiac function was assessed using echocardiography in baseline conditions, and the values were compared with those obtained after treadmill exercise according to the Bruce protocol.
  
  
  RESULTS
  Left ventricular (LV) ejection fraction decreased after exercise in men, but not in women. Parameters of LV diastolic function were likely to change unfavorably in both sexes after exercise. NT-proBNP levels were significantly elevated by exercise in both sexes (from 22.1±18.3 to 24.7±20.2 pg/mL, P=0.006 in men; from 41.1±21.5 to 46.5±24.9 pg/mL, P<0.001 in women). Changes in NT-proBNP levels were significantly associated with those in E wave velocity, E wave deceleration time, E/e' and E/propagation velocity (Vp) in men (P<0.05 for each) even after controlling for the effects of blood pressure and heart rate. In women, there were no significant associations between changes in parameters of LV diastolic function and those in NT-proBNP levels.
  
  
  CONCLUSIONS
  LV systolic and diastolic functions may deteriorate, and proBNP levels could be elevated even by a single bout of treadmill exercise in untrained young subjects. Dynamic change in LV diastolic function is a major stimulus to NT-proBNP release following exercise in men but not in women.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.|Cardiovascular Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Hack L
authors.initials: HL
authors.lastname: Kim
authors.affiliation: Cardiovascular Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: You N
authors.initials: YN
authors.lastname: Kim
authors.affiliation: Cardiovascular Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Seon K
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.|Cardiovascular Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jae B
authors.initials: JB
authors.lastname: Seo
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.|Cardiovascular Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Woo Y
authors.initials: WY
authors.lastname: Chung
authors.affiliation: Department of Laboratory Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Sue
authors.initials: S
authors.lastname: Shin
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.|Cardiovascular Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Sang H
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jong H
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.|Cardiovascular Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Myung A
authors.initials: MA
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea - jooheezo@hanmail.net.|Cardiovascular Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Joo H
authors.initials: JH
authors.lastname: Zo
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D004452:Echocardiography; D015444:Exercise / Q000502:physiology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011446:Prospective Studies; D056910:Republic of Korea; D013599:Systole; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain