title: Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study.
abstract: This study examined the effect of Testofen, a specialised Trigonella foenum-graecum seed extract on the symptoms of possible androgen deficiency, sexual function and serum androgen concentrations in healthy aging males. This was a double-blind, randomised, placebo-controlled trial involving 120 healthy men aged between 43 and 70 years of age. The active treatment was standardised Trigonella foenum-graecum seed extract at a dose of 600 mg/day for 12 weeks. The primary outcome measure was the change in the Aging Male Symptom questionnaire (AMS), a measure of possible androgen deficiency symptoms; secondary outcome measures were sexual function and serum testosterone. There was a significant decrease in AMS score over time and between the active and placebo groups. Sexual function improved, including number of morning erections and frequency of sexual activity. Both total serum testosterone and free testosterone increased compared to placebo after 12 weeks of active treatment. Trigonella foenum-graecum seed extract is a safe and effective treatment for reducing symptoms of possible androgen deficiency, improves sexual function and increases serum testosterone in healthy middle-aged and older men.
authors.affiliation: a Department of Medicine , University of Sydney , Sydney , Australia .
authors.forename: Amanda
authors.initials: A
authors.lastname: Rao
authors.affiliation: b Integrated Health Group, Clinical Research , Brisbane , Australia .
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Steels
authors.affiliation: c Department of Diabetes and Endocrinology , Princess Alexandra Hospital , Brisbane , Australia , and.
authors.forename: Warrick J
authors.initials: WJ
authors.lastname: Inder
authors.affiliation: a Department of Medicine , University of Sydney , Sydney , Australia .
authors.forename: Suzanne
authors.initials: S
authors.lastname: Abraham
authors.affiliation: a Department of Medicine , University of Sydney , Sydney , Australia .|d Medlab Pty Ltd , Sydney , Australia.
authors.forename: Luis
authors.initials: L
authors.lastname: Vitetta
mesh_terms: D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005058:Eunuchism / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use*; D012639:Seeds / Q000737:chemistry; D012725:Sexual Behavior / Q000187:drug effects*; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood* / Q000172:deficiency; D029910:Trigonella / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D013739:Testosterone
keywords: Ageing male syndrome; Trigonella foenum-graecum; androgens; sexual function; testofen; testosterone