title: Effect of Dietary Complex Lipids on the Biosynthesis of Piglet Brain Gangliosides.
abstract: Gangliosides, found in mammalian milk, are known for their roles in brain development of the newborn. However, the mechanism involved in the impact of dietary gangliosides on brain metabolism is not fully understood. The impact of diets containing complex lipids rich in milk-derived ganglioside GD3 on the biosynthesis of gangliosides (assessed from the incorporation of deuterium) in the frontal lobe of a piglet model is reported. Higher levels of incorporation of deuterium was observed in the GM1 and GD1a containing stearic acid in samples from piglets fed milk containing 18.2 μg/mL of GD3 compared to that in those fed milk containing 25 μg/mL of GD3. This could suggest that the gangliosides from the diet may be used as a precursor for de novo biosynthesis of brain gangliosides or lead to the reduction of de novo biosynthesis of these gangliosides. This effect was more pronounced in the left compared to that in the right brain hemisphere.
authors.affiliation: Food Assurance & Meat Quality Team, Food & Bio-Based Products Group, AgResearch Ruakura , Hamilton 3240, New Zealand.
authors.forename: Marlon M
authors.initials: MM
authors.lastname: Reis
authors.affiliation: Food Nutrition & Health Team, Food & Bio-Based Products Group, AgResearch Grasslands , Palmerston North 4442, New Zealand.
authors.forename: Emma N
authors.initials: EN
authors.lastname: Bermingham
authors.affiliation: Dairy Foods Team, Food & Bio-Based Products Group, AgResearch Ruakura , Hamilton 3240, New Zealand.
authors.forename: Mariza G
authors.initials: MG
authors.lastname: Reis
authors.affiliation: Protein & Biomaterials Team, AgResearch Lincoln , Christchurch 8140, New Zealand.
authors.forename: Santanu
authors.initials: S
authors.lastname: Deb-Choudhury
authors.affiliation: Fonterra Research and Development Centre , Palmerston North 4442, New Zealand.
authors.forename: Alastair
authors.initials: A
authors.lastname: MacGibbon
authors.affiliation: Fonterra Research and Development Centre , Palmerston North 4442, New Zealand.
authors.forename: Bertram
authors.initials: B
authors.lastname: Fong
authors.affiliation: Fonterra Research and Development Centre , Palmerston North 4442, New Zealand.
authors.forename: Paul
authors.initials: P
authors.lastname: McJarrow
authors.affiliation: Food Nutrition & Health Team, Food & Bio-Based Products Group, AgResearch Grasslands , Palmerston North 4442, New Zealand.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Bibiloni
authors.affiliation: Food Nutrition & Health Team, Food & Bio-Based Products Group, AgResearch Grasslands , Palmerston North 4442, New Zealand.
authors.forename: Shalome A
authors.initials: SA
authors.lastname: Bassett
authors.affiliation: Food Nutrition & Health Team, Food & Bio-Based Products Group, AgResearch Grasslands , Palmerston North 4442, New Zealand.
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Roy
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D005732:Gangliosides / Q000096:biosynthesis*; D013552:Swine
chemical_list: D004041:Dietary Fats; D005732:Gangliosides
keywords: GD3; frontal cortex lobe; piglets