title: Advanced Lymphocyte-rich Classical Hodgkin Lymphoma Complicated with Fatal Hemophagocytic Syndrome.
abstract: Lymphocyte-rich classical Hodgkin lymphoma (LRCHL) is a rare subtype of Hodgkin lymphoma with a favorable prognosis, and an aggressive clinical course of LRCHL is uncommon. A 55-year-old man suffering from swelling in the left neck was diagnosed with LRCHL with extranodal lesions in the lung and bone marrow. Initially, he received standard ABVD chemotherapy; however, disease progression, accompanied by hemophagocytic syndrome (HPS), occurred during the second course of ABVD. He received two subsequent courses of intensive chemotherapy containing high-dose steroids, cyclophosphamide, and etoposide. Nevertheless, this therapy was only temporarily effective, and he died of due to an aggressive disease progression accompanied by uncontrollable HPS and severe coagulopathy.
authors.affiliation: Department of Hematology, Osaki Citizen Hospital, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ichikawa
authors.forename: Taro
authors.initials: T
authors.lastname: Takahashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Katsushima
authors.forename: Noriko
authors.initials: N
authors.lastname: Fukuhara
authors.forename: Ryo
authors.initials: R
authors.lastname: Ichinohasama
authors.forename: Hideo
authors.initials: H
authors.lastname: Harigae
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000627:therapeutic use; D019046:Bone Marrow Neoplasms / Q000556:secondary; D003606:Dacarbazine / Q000627:therapeutic use; D018450:Disease Progression; D004317:Doxorubicin / Q000627:therapeutic use; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000473:pathology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin