title: Effect of odanacatib on root resorption and alveolar bone metabolism during orthodontic tooth movement.
abstract: The aim of this study was to investigate the effect of local administration of odanacatib (ODN) on orthodontic root resorption and the status of alveolar bone metabolism in rat molars. All specimens were scanned using microcomputed tomography and then the raw images were reconstructed. The total volume of the root resorption craters of the 60 g-NS (normal saline) group was higher than in the 60 g-ODN group and the control group. In the 60 g-NS group, the bone volume fraction values of alveolar bone were significantly decreased compared with the other 2 groups. There were no significant differences in the bone volume fraction values of the tibiae among the 3 groups. The results of tartrate-resistant acid phosphatase-positive (TRAP+) numbers showed that there was no difference between the 60 g-NS group and the 60 g-ODN group. The expression of cathepsin K was decreased significantly in the 60 g-ODN group. These results indicate that ODN reduces orthodontics-induced external root resorption and increases alveolar bone metabolism. This may be because ODN inhibits the activity of odontoclasts, but maintains the quantity of odontoclasts and enhances bone formation. ODN promotes local alveolar bone metabolism, but does not affect systemic bone metabolism.
authors.affiliation: Department of Orthodontics, Capital Medical University School of Stomatology, Beijing, China.|Department of Orthodontics, Zhengzhou University School of Stomatology, Zhengzhou, China.
authors.forename: X X
authors.initials: XX
authors.lastname: Wei
authors.affiliation: Department of Endodontics, Zhengzhou University School of Stomatology, Zhengzhou, China.
authors.forename: J P
authors.initials: JP
authors.lastname: Chu
authors.affiliation: Department of Orthodontics, Zhengzhou University School of Stomatology, Zhengzhou, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Zou
authors.affiliation: Department of Orthodontics, Capital Medical University School of Stomatology, Beijing, China.
authors.forename: N
authors.initials: N
authors.lastname: Ru
authors.affiliation: Department of Orthodontics, Zhengzhou University School of Stomatology, Zhengzhou, China.
authors.forename: S X
authors.initials: SX
authors.lastname: Cui
authors.affiliation: Department of Orthodontics, Capital Medical University School of Stomatology, Beijing, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Bai
mesh_terms: D016301:Alveolar Bone Loss / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001713:Biphenyl Compounds / Q000008:administration & dosage*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D056657:Cathepsin K / Q000096:biosynthesis; D006801:Humans; D008963:Molar / Q000378:metabolism / Q000473:pathology; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D012391:Root Resorption / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014087:Tooth Movement Techniques; D055114:X-Ray Microtomography
chemical_list: D001713:Biphenyl Compounds; D056657:Cathepsin K; C527128:odanacatib