title: Rational Design of Targeted Next-Generation Carriers for Drug and Vaccine Delivery.
abstract: Pattern recognition receptors on innate immune cells play an important role in guiding how cells interact with the rest of the organism and in determining the direction of the downstream immune response. Recent advances have elucidated the structure and function of these receptors, providing new opportunities for developing targeted drugs and vaccines to treat infections, cancers, and neurological disorders. C-type lectin receptors, Toll-like receptors, and folate receptors have attracted interest for their ability to endocytose their ligands or initiate signaling pathways that influence the immune response. Several novel technologies are being developed to engage these receptors, including recombinant antibodies, adoptive immunotherapy, and chemically modified antigens and drug delivery vehicles. These active targeting technologies will help address current challenges facing drug and vaccine delivery and lead to new tools to treat human diseases.
authors.affiliation: Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011; email: nbalaji@iastate.edu.
authors.forename: Balaji
authors.initials: B
authors.lastname: Narasimhan
authors.affiliation: Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011; email: nbalaji@iastate.edu.
authors.forename: Jonathan T
authors.initials: JT
authors.lastname: Goodman
authors.affiliation: Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011; email: nbalaji@iastate.edu.
authors.forename: Julia E
authors.initials: JE
authors.lastname: Vela Ramirez
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D058990:Molecular Targeted Therapy / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D014612:Vaccines / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D014612:Vaccines
keywords: C-type lectin receptors; Toll-like receptors; brain drug delivery; cancer; drug delivery vehicles; folate receptors