title: Visible-light photoredox intramolecular difluoroacetamidation: facile synthesis of 3,3-difluoro-2-oxindoles from bromodifluoroacetamides.
abstract: We report an operationally simple, visible-light-driven protocol for intramolecular C-H difluoroacetamidation of arenes for the synthesis of biologically relevant 3,3-difluoro-2-oxindoles at room temperature. Using fac-Ir(ppy)3 as a photocatalyst and a 3 W blue LED as a light source, an array of difluoroxindoles was prepared from rapidly available tertiary aryl bromodifluoroacetamides in moderate to excellent yields.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 222 South Tianshui Road, Lanzhou 730000, P. R. China. liuqiang@lzu.edu.cn.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Wei
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Shao-Fu
authors.initials: SF
authors.lastname: Du
authors.forename: Li-Zhu
authors.initials: LZ
authors.lastname: Wu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu