title: Correlation between serum YKL-40 levels and albuminuria in type 2 diabetes.
abstract: We explored the correlation between serum YKL-40 levels and albuminuria in type 2 diabetes mellitus (T2DM) and its clinical significance. This study used a cross-sectional survey method. According to the American Diabetes Association 2007 Clinical Practice Recommendations, 738 patients with T2DM were divided into three groups: a normoalbuminuria group [albumin-to-creatinine ratio (ACR) <30 μg/mg, N = 360], a microalbuminuria group (ACR 30-300 μg/mg, N = 246), and a macroalbuminuria group (ACR ≥ 300 μg/mg, N = 332). The serum YKL-40 levels were determined by a quantitative sandwich enzyme-linked immunosorbent assay in all the cases and in 210 control subjects. Serum YKL-40 levels were significantly higher in the T2DM group vs the control group (P < 0.05), the macroalbuminuria group vs the microalbuminuria group (P < 0.05), and the microalbuminuria group vs the normoalbuminuria group (P < 0.05). Serum YKL-40 levels correlated with ACR in all participants. Significant correlation of YKL-40 was found with ACR, 2-h plasma glucose, glycated hemoglobin, fasting blood glucose, homeostatic model assessment of insulin resistance index, systolic blood pressure, duration, diastolic blood pressure, age, triglycerides, and high-density lipoprotein cholesterol (r-values: 0.713, 0.524, 0.515, 0.467, 0.438, 0.409, 0.407, 0.374, 0.112, 0.097, and -0.123, respectively). ACR correlated with serum YKL-40 levels (Beta = 0.555, P < 0.001). YKL-40 may be involved in the occurrence and development of diabetic nephropathy and would be useful as a new marker for the disease.
authors.affiliation: The Geriatrics Department, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Han
authors.affiliation: The Geriatrics Department, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Ma
authors.affiliation: The Geriatrics Department, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
authors.forename: L J
authors.initials: LJ
authors.lastname: Yu
authors.affiliation: The Endocrine Department, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Shao
authors.affiliation: The Endocrine Department, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Wang
mesh_terms: D000419:Albuminuria / Q000175:diagnosis / Q000209:etiology*; D015415:Biomarkers; D000071451:Chitinase-3-Like Protein 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1