title: Refractory Immunological Thrombocytopenia Purpura and Splenectomy in Pregnancy.
abstract: Thrombocytopenia is defined as a platelet count of less than 100,000 platelets per microlitre (mcL). Thrombocytopenia develops in approximately 6-7% of women during pregnancy and at least 3% of these cases are caused by immunological platelet destruction. Herein, we present a pregnant woman who develops at the first trimester autoimmune thrombocytopenia purpura associated with positive antiphospholipid antibodies. The disease was refractory to pharmacological treatments but had a favourable response to splenectomy. The patient carried the pregnancy to term without complication and gave birth to a healthy baby girl.
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Santiago
authors.initials: S
authors.lastname: Bernal-Macías
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Laura-Marcela
authors.initials: LM
authors.lastname: Fino-Velásquez
authors.affiliation: Surgery Department, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; Surgery Department, Hospital Universitario Mayor-Mederi (HUM), Bogotá, Colombia.
authors.forename: Felipe E
authors.initials: FE
authors.lastname: Vargas-Barato
authors.affiliation: Gynaecology Department, Hospital Universitario Mayor-Mederi (HUM), Bogotá, Colombia.
authors.forename: Lucio
authors.initials: L
authors.lastname: Guerra-Galue
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Benjamín
authors.initials: B
authors.lastname: Reyes-Beltrán
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Adriana
authors.initials: A
authors.lastname: Rojas-Villarraga