title: Lessons from Animal Models of Arterial Aneurysm.
abstract: We review the results from the most common animal models of arterial aneurysm, including recent findings from our novel, laparoscopy-based pig model of abdominal aortic aneurysm, that contribute important insights into early pathogenesis. We emphasize the relevance of these findings for evaluation of treatment protocols and novel device prototypes for mechanism-based prevention of progression and rupture.
authors.affiliation: Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel.
authors.forename: S David
authors.initials: SD
authors.lastname: Gertz
authors.affiliation: Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Yoav
authors.initials: Y
authors.lastname: Mintz
authors.affiliation: Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Ronen
authors.initials: R
authors.lastname: Beeri
authors.affiliation: Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Chen
authors.initials: C
authors.lastname: Rubinstein
authors.affiliation: Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Dan
authors.initials: D
authors.lastname: Gilon
authors.affiliation: Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Leah
authors.initials: L
authors.lastname: Gavish
authors.affiliation: Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Yacov
authors.initials: Y
authors.lastname: Berlatzky
authors.affiliation: Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Liat
authors.initials: L
authors.lastname: Appelbaum
authors.affiliation: Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Lilach
authors.initials: L
authors.lastname: Gavish
keywords: Abdominal aortic aneurysm; Animal models; Arterial aneurysm; Periarterial calcium chloride