title: Neurovascular Interactions in the Neurologically Compromised Neonatal Brain.
abstract: Neurological brain injuries such as hypoxic ischaemic encephalopathy (HIE) and associated conditions such as seizures have been associated with poor developmental outcome in neonates. Our limited knowledge of the neurological and cerebrovascular processes underlying seizures limits their diagnosis and timely treatment. Diffuse optical tomography (DOT) provides haemodynamic information in the form of changes in concentration of de/oxygenated haemoglobin, which can improve our understanding of seizures and the relationship between neural and vascular processes. Using simultaneous EEG-DOT, we observed distinct haemodynamic changes which are temporally correlated with electrographic seizures. Here, we present DOT-EEG data from two neonates clinically diagnosed as HIE. Our results highlight the wealth of mutually-informative data that can be obtained using DOT-EEG techniques to understand neurovascular coupling in HIE neonates.
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK. harsimrat.singh@ucl.ac.uk.|BORL, Department of Medical Physics and Bioengineering, UCL, London, UK. harsimrat.singh@ucl.ac.uk.
authors.forename: H
authors.initials: H
authors.lastname: Singh
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|BORL, Department of Medical Physics and Bioengineering, UCL, London, UK.
authors.forename: R
authors.initials: R
authors.lastname: Cooper
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|Neonatal Unit, Rosie Hospital, Cambridge University Hospitals, Cambridge, UK.
authors.forename: C W
authors.initials: CW
authors.lastname: Lee
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|BORL, Department of Medical Physics and Bioengineering, UCL, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Dempsey
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|BORL, Department of Medical Physics and Bioengineering, UCL, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Brigadoi
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|Neonatal Unit, Rosie Hospital, Cambridge University Hospitals, Cambridge, UK.
authors.forename: A
authors.initials: A
authors.lastname: Edwards
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|Neonatal Unit, Rosie Hospital, Cambridge University Hospitals, Cambridge, UK.
authors.forename: D
authors.initials: D
authors.lastname: Airantzis
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|BORL, Department of Medical Physics and Bioengineering, UCL, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Everdell
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|Neonatal Unit, Rosie Hospital, Cambridge University Hospitals, Cambridge, UK.
authors.forename: A
authors.initials: A
authors.lastname: Michell
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|Neonatal Unit, Rosie Hospital, Cambridge University Hospitals, Cambridge, UK.
authors.forename: D
authors.initials: D
authors.lastname: Holder
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|Neonatal Unit, Rosie Hospital, Cambridge University Hospitals, Cambridge, UK.
authors.forename: T
authors.initials: T
authors.lastname: Austin
authors.affiliation: neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.|BORL, Department of Medical Physics and Bioengineering, UCL, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Hebden
mesh_terms: D001921:Brain; D004569:Electroencephalography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology*; D007231:Infant, Newborn; D008297:Male; D012640:Seizures / Q000503:physiopathology; D041622:Tomography, Optical
keywords: Burst suppression; Diffuse optical tomography; Hypoxic–ischaemic encephalopathy; Neonatal seizures; Neurovascular coupling