title: Review: Multiple system atrophy: emerging targets for interventional therapies.
abstract: Multiple system atrophy (MSA) is a fatal orphan neurodegenerative disorder that manifests with rapidly progressive autonomic and motor dysfunction. The disease is characterized by the accumulation of α-synuclein fibrils in oligodendrocytes that form glial cytoplasmic inclusions, a neuropathological hallmark and central player in the pathogenesis of MSA. Here, we summarize the current knowledge on the etiopathogenesis and neuropathology of MSA. We discuss the role of α-synuclein pathology, microglial activation, oligodendroglial dysfunction and putative cell death mechanisms as candidate therapeutic targets in MSA.
authors.affiliation: Division of Neurobiology, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: N
authors.initials: N
authors.lastname: Stefanova
authors.affiliation: Division of Neurobiology, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: G K
authors.initials: GK
authors.lastname: Wenning
mesh_terms: D000818:Animals; D006801:Humans; D019578:Multiple System Atrophy / Q000473:pathology*; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein
keywords: aetiology; clinical trial; multiple system atrophy; neuropathology; pathogenesis; α-synuclein