title: Post-translational Modifications in Heart Failure: Small Changes, Big Impact.
abstract: Heart failure is a complex disease process with various aetiologies and is a significant cause of morbidity and death world-wide. Post-translational modifications (PTMs) alter protein structure and provide functional diversity in terms of physiological functions of the heart. In addition, alterations in protein PTMs have been implicated in human disease pathogenesis. Small ubiquitin-like modifier mediated modification (SUMOylation) pathway was found to play essential roles in cardiac development and function. Abnormal SUMOylation has emerged as a new feature of heart failure pathology. In this review, we will highlight the importance of SUMOylation as a regulatory mechanism of SERCA2a function, and its therapeutic potential for the treatment of heart failure.
authors.affiliation: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: Ahyoung
authors.initials: A
authors.lastname: Lee
authors.affiliation: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: Jae Gyun
authors.initials: JG
authors.lastname: Oh
authors.affiliation: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: Przemek A
authors.initials: PA
authors.lastname: Gorski
authors.affiliation: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Hajjar
authors.affiliation: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: changwon.kho@mssm.edu.
authors.forename: Changwon
authors.initials: C
authors.lastname: Kho
mesh_terms: D000818:Animals; D006333:Heart Failure / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D006801:Humans; D009124:Muscle Proteins / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000378:metabolism*; D058207:Sumoylation
chemical_list: D009124:Muscle Proteins; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; C506946:ATP2A2 protein, human
keywords: Heart failure; Post-translational modifications; SERCA2a; SUMO