title: Pancreatectomy in Patients with Impaired Renal Function: How Risky Is It?
abstract: Chronic renal impairment causes profound physiologic and metabolic changes. Its impact on surgical outcome after pancreatectomy is not well established. We sought to quantify complication rates of pancreatectomy in patients with chronic renal impairment. Database from the American College of Surgeons National Surgical Quality Improvement Project (2005-2011) was queried to identify patients with chronic renal impairment who underwent pancreatectomy. The study population consisted of 16,708 patients of whom 16,649 patients were not on dialysis and 59 patients were on dialysis. Overall mortality for those on dialysis was 5.1 per cent, whereas it was 2.3 per cent for those not on dialysis (P = 0.114). Patients on dialysis were more likely to have failure to wean ventilation (P < 0.001), reintubation (P = 0.004), myocardial infarction (P = 0.007), and sepsis (P = 0.046). Patients not on dialysis were then divided into three groups: serum creatinine levels <1.2 mg/dL, between 1.2 mg/dL and 2.0 mg/dL, and >2.0 mg/dL. We found the mortality rates for these three groups were 2.0 per cent, 4.6 per cent, and 7.5 per cent, respectively (P < 0.001). In conclusion, need for dialysis is associated with increased postoperative complications. Increased serum creatinine levels were associated with increased mortality rates. These findings should facilitate informative risk/benefit calculation for patients with renal impairment who are considering pancreatectomy.
authors.affiliation: Department of Surgical Oncology, West Virginia University Hospitals, Morgantown, West Virginia, USA.
authors.forename: Jared
authors.initials: J
authors.lastname: Feyko
authors.forename: Hannah
authors.initials: H
authors.lastname: Hazard
authors.forename: Jon
authors.initials: J
authors.lastname: Cardinal
authors.forename: Alan
authors.initials: A
authors.lastname: Thomay
authors.forename: Sung
authors.initials: S
authors.lastname: Cho
mesh_terms: D000368:Aged; D002423:Cause of Death; D003404:Creatinine / Q000097:blood; D016208:Databases, Factual; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods / Q000401:mortality*; D010190:Pancreatic Neoplasms / Q000601:surgery; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D006435:Renal Dialysis / Q000379:methods; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome; D014481:United States
chemical_list: D003404:Creatinine