title: Microaneurysms in renal angiomyolipomas: Can clinical and computed tomography features predict their presence and size?
abstract: OBJECTIVE
  To evaluate clinical and multidetector computed tomography (MDCT) features associated with the presence and size of microaneurysms in renal angiomyolipomas (AMLs).
  
  
  METHODS
  The MDCTs and digital subtraction angiographies (DSAs) of 31 patients who had further percutaneous arterial embolization of AMLs were retrospectively reviewed. They were 22 women and 9 men (mean age, 47.7±27.7 years). The medical files of the included patients were reviewed for age, gender and clinical features. MDCT and DSA images were analyzed by two readers working in consensus.
  
  
  RESULTS
  Of the 31 patients, 15 had tuberous sclerosis complex (TSC) or lymphangioleiomyomatosis (LAM). In total, the 31 patients had 54 AMLs (5 ruptured). On DSA, 28 clusters of microaneurysms were found in 17 patients (21 AMLs). Four of the five ruptured AMLs had microaneurysms. None of the 12 AMLs≤40mm and 21 of the 42 AMLs>40mm had microaneurysms. Among AMLs>40mm, history of TSC/LAM (P=0.5), RENAL score (P=0.7) and relative volume of fat (P=0.11) did not significantly predict the presence of microaneurysms. Microaneurysms were significantly larger in ruptured (9.5±5.7mm) than non-ruptured (3.9±1.9mm, P=0.02) AMLs. No associations were found between the size of microaneurysms and the size of AMLs.
  
  
  CONCLUSIONS
  Microaneurysms were found in no AML ≤40mm and in 50%of AMLs>40mm. In AMLs >40mm, history of TSC/LAM, RENAL score and relative volume of fat did not significantly predict the presence of microaneurysms.
authors.affiliation: Department of Urinary and Vascular Radiology, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France.
authors.forename: J
authors.initials: J
authors.lastname: Champagnac
authors.affiliation: Laboratoire d'Écologie Alpine, Université Joseph Fourier, BP 53, 38041 Grenoble, France; CNRS, UMR 5553, BP 53, 38041 Grenoble, France.
authors.forename: C
authors.initials: C
authors.lastname: Melodelima
authors.affiliation: Department of Imaging, centre hospitalier de Valence, 26000 Valence, France.
authors.forename: T
authors.initials: T
authors.lastname: Martinelli
authors.affiliation: Department of Urinary and Vascular Radiology, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France.
authors.forename: G
authors.initials: G
authors.lastname: Pagnoux
authors.affiliation: Université de Lyon, 69003 Lyon, France; Faculté de médecine Lyon Est, université Lyon 1, 69003 Lyon, France; Department of Urology, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Badet
authors.affiliation: Université de Lyon, 69003 Lyon, France; Faculté de médecine Lyon Est, université Lyon 1, 69003 Lyon, France; Department of Nephrology, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Juillard
authors.affiliation: Department of Urinary and Vascular Radiology, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France; Université de Lyon, 69003 Lyon, France; Faculté de médecine Lyon Est, université Lyon 1, 69003 Lyon, France. Electronic address: Olivier.rouviere@netcourrier.com.
authors.forename: O
authors.initials: O
authors.lastname: Rouvière
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018207:Angiomyolipoma / Q000098:blood supply*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000098:blood supply*; D008297:Male; D000071071:Microaneurysm / Q000000981:diagnostic imaging* / Q000473:pathology*; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D055815:Young Adult
keywords: Computed tomography; Digital subtraction angiography; Microaneurysm; Renal angiomyolipoma