title: [Efficacy of adjuvant therapy in 110 patients with N1 lymph node metastasis of esophageal squamous cell carcinoma].
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of postoperative adjuvant therapy on the survival in patients with N1 lymph node metastasis of esophageal squamous cell carcinoma (ESCC).
  
  
  METHODS
  110 patients with positive N1 lymph node metastasis of esophageal squamous carcinoma were included in this study. The surgery group included 46 cases and the postoperative adjuvant therapy group included 64 cases (24 cases in the adjuvant chemotherapy subgroup and 40 cases in the adjuvant concurrent chemoradiotherapy). The disease-free survival (DFS) and overall survival (OS) of the two groups were compared and the prognostic factors were analyzed by multivariate Cox model.
  
  
  RESULTS
  In the postoperative adjuvant therapy group, the DFS (16.8 months) and OS (21.3 months) were significantly prolonged compared with those in the surgery group (10.6 months, P=0.007) and (13.7 months, P=0.001), respectively. Postoperative adjuvant chemotherapy significantly extended the OS (31.1 months) of N1-positive patients compared with 13.7 months (P=0.002) in the surgery group. But there were no significant differences between the DFS in the two subgroups (16.3 and 16.8 months, P=0.346) and between the OS (23.4 and 21.3 months, P=0.491). Postoperative adjuvant therapy was an independent prognostic factor in the ESCC patients with N1 lymph node metastasis.
  
  
  CONCLUSIONS
  Postoperative adjuvant therapy can improve the prognosis and prolong the survival time in ESCC patients with positive N1 lymph node metastasis.
authors.affiliation: Department of Thoracic Surgery, the First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Guoguang
authors.initials: G
authors.lastname: Shao
authors.affiliation: Cancer Center, the First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Cancer Center, the First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Xinxing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, the First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, the First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Youbin
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Cancer Center, the First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Liang
authors.affiliation: Cancer Center, the First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Kewei
authors.initials: K
authors.lastname: Ma
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D059248:Chemoradiotherapy; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D011182:Postoperative Care; D011379:Prognosis; D012189:Retrospective Studies