title: Regulation of midbody formation and function by mitotic kinases.
abstract: Cytokinesis is the final phase of cell division and safeguards the correct distribution of genomic and cytoplasmic materials between the two nascent daughter cells. The final separation, or abscission, of the daughter cells depends on the proper assembly of an organelle at the intercellular bridge, the midbody, which acts as a platform for the recruitment and organisation of various proteins involved in both the control and execution of the abscission process. Recent studies have led to the identification of the mechanisms, signalling pathways and molecules that control the two tightly linked processes of midbody formation and abscission. Here we review our current knowledge of the role that mitotic kinases play in these processes and offer our perspectives on the potential future challenges that await researchers in the field.
authors.affiliation: Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. Electronic address: ppd21@cam.ac.uk.
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: D'Avino
authors.affiliation: Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
authors.forename: Luisa
authors.initials: L
authors.lastname: Capalbo
mesh_terms: D000818:Animals; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism
chemical_list: D011494:Protein Kinases
keywords: Abscission; Cell division; Cytokinesis; Kinases; Midbody