title: SAPHO syndrome presenting as an osteolytic lesion of the neck.
abstract: We report a case of acute-onset multifocal vertebral osteitis with a marked impact on the patient's general health. The radiological, scintigraphic and magnetic resonance findings made it necessary to carry out a differential diagnosis to distinguish it from an infiltrative neoplastic process and determine whether it had an infectious or an inflammatory etiology. The presence of noninfectious multifocal osteitis and sternoclavicular arthritis and the subsequent development of plantar pustulosis pointed to SAPHO syndrome. Treatment with infliximab led to improvement in the clinical symptoms, laboratory values and radiological abnormalities.
authors.affiliation: Servicio de Reumatología, Hospital Universitari Germans Trias i Pujol, Barcelona, España. Electronic address: lmateo.germanstrias@gencat.cat.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Mateo
authors.affiliation: Servicio de Reumatología, Hospital Universitari Germans Trias i Pujol, Barcelona, España.
authors.forename: Juana
authors.initials: J
authors.lastname: Sanint
authors.affiliation: Servicio de Reumatología, Hospital Universitari Germans Trias i Pujol, Barcelona, España.
authors.forename: Samantha
authors.initials: S
authors.lastname: Rodríguez Muguruza
authors.affiliation: Servicio de Reumatología, Hospital Universitari Germans Trias i Pujol, Barcelona, España.
authors.forename: Melania
authors.initials: M
authors.lastname: Martínez Morillo
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitari Germans Trias i Pujol, Barcelona, España.
authors.forename: Ricard
authors.initials: R
authors.lastname: Pérez Andrés
authors.affiliation: Unidad de Resonancia magnética (IDI), Hospital Universitari Germans Trias i Pujol, Barcelona, España.
authors.forename: Sira
authors.initials: S
authors.lastname: Domenech Puigcerver
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000150:complications / Q000175:diagnosis*; D002574:Cervical Vertebrae; D005260:Female; D006801:Humans; D008875:Middle Aged; D010014:Osteolysis / Q000209:etiology*
keywords: Artritis psoriásica; Aseptic osteomyelitis; Lesiones osteolíticas; Multifocal vertebral osteomyelitis; Osteolytic lesions; Osteomielitis aséptica; Osteomielitis vertebral múltiple; Psoriatic arthritis; SAPHO