title: Myomas: anatomy and related issues.
abstract: Myomas are the most common disorder of the female genital organs, occurring more frequently throughout women's reproductive years. Myomas are a major health issue all over the world. They develop as a monoclonal tumor from cells influenced by ovarian steroids, and mediated by surrounding myometrial cells by paracrine mechanisms. During its growth, a myoma compresses the surrounding tissue, causing the formation of a pseudocapsule, encapsulating the myoma. The mechanical properties of myomas are a key factor which can contribute to their growth. While myomas are essentially rigid, their pseudocapsule is more elastic, and this allows uterine adaptation to the growing myoma. Hence, the pseudocapsule induces displacement on the myometrium, which is not destructive since the integrity and contractility of uterine structure is maintained. Extensive research conducted on the myoma and its pseudocapsule has produced important data. Scientific research is still trying to clarify some of the evidence regarding the influence of myomas on infertility, especially in the case of intramural myomas. During fertility-sparing myoma surgery, data suggest that during myoma removal the pseudocapsule should be preserved. However, unsolved issues still exist on the cesarean myomectomy technique, since the age of pregnancy has been increasing in the new millennium, so patients present with myomas which should be removed before and during the cesarean section, or prior to applying for medically-assisted reproduction.
authors.affiliation: Division of Experimental Endoscopic Surgery, Imaging, Technology and Minimally Invasive Therapy, Department of Obstetrics and Gynecology, "Vito Fazzi" Hospital, Lecce, Italy - andreatinelli@gmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Tinelli
authors.forename: Radmila
authors.initials: R
authors.lastname: Sparic
authors.forename: Saša
authors.initials: S
authors.lastname: Kadija
authors.forename: Ivana
authors.initials: I
authors.lastname: Babovic
authors.forename: Raffaele
authors.initials: R
authors.lastname: Tinelli
authors.forename: Ospan A
authors.initials: OA
authors.lastname: Mynbaev
authors.forename: Antonio
authors.initials: A
authors.lastname: Malvasi
mesh_terms: D005260:Female; D059247:Fertility Preservation; D014943:Global Health; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D007889:Leiomyoma / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D063186:Uterine Myomectomy / Q000379:methods; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery