title: [A Case of Colon Cancer with Multiple Liver Metastases Successfully Treated with Capecitabine/Oxaliplatin plus Bevacizumab].
abstract: A 69-year-old woman was diagnosed with descending colon cancer with multiple liver metastases, and a left hemicolectomy was performed. The patient was treated with capecitabine/oxaliplatin (CapeOX) plus bevacizumab (Bmab). After 5 courses of chemotherapy, the number and size of liver metastases remarkably reduced, and after the 12th course, because of peripheral neuropathy, a "stop-and-go"fashion of administering oxaliplatin (L-OHP) was initiated. After 14 courses, the liver metastases had disappeared. After the 33rd course of L-OHP treatment, the patient started receiving capecitabine therapy. The patient is recurrence-free 3 years after surgery, 14 months after achieving a complete response (CR). We report a case of long-term CR after surgery for descending colon cancer with multiple liver metastases, followed by a "stop-and-go" method of administering L-OHP or CapeOX plus Bmab therapy.
authors.affiliation: Dept. of Digestive and Breast Surgery, National Hospital Organization Disaster Medical Center.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Suematsu
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Miyuki
authors.initials: M
authors.lastname: Hiratsuka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suda
authors.forename: Miyuki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saito
authors.forename: Keita
authors.initials: K
authors.lastname: Omori
authors.forename: Akihiko
authors.initials: A
authors.lastname: Morita
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000008:administration & dosage; D000069287:Capecitabine / Q000008:administration & dosage; D003082:Colectomy; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D011379:Prognosis
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000068258:Bevacizumab; D000069287:Capecitabine