title: Vinegar Treatment Prevents the Development of Murine Experimental Colitis via Inhibition of Inflammation and Apoptosis.
abstract: This study investigated the preventive effects of vinegar and acetic acid (the active component of vinegar) on ulcerative colitis (UC) in mice. Vinegar (5% v/v) or acetic acid (0.3% w/v) treatment significantly reduced the disease activity index and histopathological scores, attenuated body weight loss, and shortened the colon length in a murine experimental colitis model induced by dextran sulfate sodium (DSS). Further mechanistic analysis showed that vinegar inhibited inflammation through suppressing Th1 and Th17 responses, the NLRP3 inflammasome, and MAPK signaling activation. Vinegar also inhibited endoplasmic reticulum (ER) stress-mediated apoptosis in the colitis mouse model. Surprisingly, pretreatment with vinegar for 28 days before DSS induction increased levels of the commensal lactic acid-producing or acetic acid-producing bacteria, including Lactobacillus, Bifidobacteria, and Enterococcus faecalis, whereas decreased Escherichia coli levels were found in the feces of mice. These results suggest that vinegar supplementation might provide a new dietary strategy for the prevention of UC.
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, The First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University , Changchun 130062, China.
authors.forename: Fengge
authors.initials: F
authors.lastname: Shen
authors.affiliation: College of Medicine, Yanbian University , Yanji 133000, China.
authors.forename: Jiaxuan
authors.initials: J
authors.lastname: Feng
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, The First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University , Changchun 130062, China.
authors.forename: Xinhui
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, The First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University , Changchun 130062, China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Qi
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, The First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University , Changchun 130062, China.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Shi
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, The First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University , Changchun 130062, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: An
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, The First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University , Changchun 130062, China.
authors.forename: Qiaoli
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, The First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University , Changchun 130062, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, The First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University , Changchun 130062, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses , Yangzhou 225009, China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Liu
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, The First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University , Changchun 130062, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, The First Hospital of Jilin University, College of Veterinary Medicine and College of Animal Science, Jilin University , Changchun 130062, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yu
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003093:Colitis, Ulcerative / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D003106:Colon / Q000166:cytology / Q000276:immunology*; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D051379:Mice; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology
chemical_list: D016207:Cytokines; D019342:Acetic Acid
keywords: apoptosis; colitis; inflammation; intestinal microbiota; vinegar