title: Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer.
abstract: OBJECTIVE
  To compare the diagnostic imaging ability of three different optical coherence tomography (OCT) devices in non-melanoma skin cancer (NMSC).
  
  
  METHODS
  Thirty actinic keratoses (AKs) and 27 basal cell carcinomas (BCCs) of 29 patients were examined with three different OCT devices, VivoSight®, Callisto®and Skintell®.
  
  
  RESULTS
  Complete data sets were available for 16 BCCs and 10 AKs of 18 patients. All OCT devices were able to discriminate BCCs and AKs significantly from perilesional normal skin due to lower signal intensities as well as a thicker stratum corneum and epidermis in AKs. A significant decrease in the signal intensity and thickness of all skin layers was noted with Skintell®in contrast to VivoSight®and Callisto®. OCT comparisons revealed only slight differences between VivoSight®and Callisto®. Regarding BCC tumor thickness VivoSight®and Callisto®correlated well, histology did not correlate with the three OCT devices, whereas Skintell®showed no correlation with VivoSight®, Callisto®or histology.
  
  
  CONCLUSIONS
  All tested OCT devices could identify BCCs and AKs objectively through standardized measurement of signal intensity and skin layer thickness. Due to their technical specifications (resolution, penetration depth), each of the OCT systems offers additional and special information on NMSC.
authors.affiliation: Department of Dermatology and Allergology, General Hospital Augsburg, Augsburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Schuh
authors.affiliation: Department of Dermatology and Allergology, General Hospital Augsburg, Augsburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Kaestle
authors.affiliation: Department of Dermatology and Allergology, Ludwig-Maximilian University of Munich, Munich, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Sattler
authors.affiliation: Department of Dermatology and Allergology, General Hospital Augsburg, Augsburg, Germany. julia.welzel@klinikum-augsburg.de.
authors.forename: J
authors.initials: J
authors.lastname: Welzel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D055623:Keratosis, Actinic / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D013673:Technology Assessment, Biomedical; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods
keywords: OCT devices; actinic keratosis; basal cell carcinoma; non-melanoma skin cancer; optical coherence tomography; skin imaging