title: Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients.
abstract: OBJECTIVE
  To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis.
  
  
  METHODS
  Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS - 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism with clinical and pathological data of the patients was evaluated.
  
  
  RESULTS
  We have found no significant statistical association between this polymorphism and an increased risk of developing acute pancreatitis.
  
  
  CONCLUSIONS
  In Romanian population, the risk of developing acute pancreatitis is not increased by the presence of iNOS-2087A>G polymorphism.
authors.affiliation: Research Center of Gastroenterology and Hepatology, Craiova, ROMANIA.
authors.forename: V
authors.initials: V
authors.lastname: Pădureanu
authors.affiliation: Research Center of Gastroenterology and Hepatology, Craiova, ROMANIA.
authors.forename: Ioana
authors.initials: I
authors.lastname: StreaȚă
authors.affiliation: Research Center of Gastroenterology and Hepatology, Craiova, ROMANIA.
authors.forename: M
authors.initials: M
authors.lastname: Ioana
authors.affiliation: Research Center of Gastroenterology and Hepatology, Craiova, ROMANIA.
authors.forename: V
authors.initials: V
authors.lastname: Șurlin
authors.affiliation: Research Center of Gastroenterology and Hepatology, Craiova, ROMANIA.
authors.forename: E F
authors.initials: EF
authors.lastname: Georgescu
authors.affiliation: Research Center of Gastroenterology and Hepatology, Craiova, ROMANIA.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mărginean
authors.affiliation: Research Center of Gastroenterology and Hepatology, Craiova, ROMANIA.
authors.forename: A
authors.initials: A
authors.lastname: Săftoiu
keywords: acute pancreatitis; genotype; iNOS; polymorphism