title: [Plasmablastic lymphoma: a clinicopathologic analysis of 11 cases with review of literature].
abstract: OBJECTIVE
  To investigate the clinicpathologic features and diagnosis of plasmablastic lymphoma (PBL).
  
  
  METHODS
  Eleven cases of PBL were collected and followed up, with review of the literature. HIV and EBV status and their relationships with the tumor were specially compared as well.
  
  
  RESULTS
  In the current cohort, 10 patients were serologically HIV negative; the male to female ratio was 8 to 3, and the median age was 57 years. Ten cases showed extranodal involvement and one case was nodal based. At presentation, five patients had mid-facial involvement, including sinonasal area (3 cases) and oral cavity (2 cases). Histologically, six were PBL of oral mucosa type, and five were PBL with plasmacytic differentiation. In all cases, the neoplastic cells expressed CD138 and MUM-1, and were negative for CD20 and CD3ε; the median Ki-67 index was 80%. Five cases were EBER1/2 in situ hybridization positive. IgH or/and Igκ gene rearrangement was detected in all five cases examined.
  
  
  CONCLUSIONS
  Most patients were no congenital or acquired immunodeficiency in the retrospective study. Of the died patients, EBER1/2 in situ hybridization were negative and their disease staging were Ⅳ, The neoplastic cells were immunoblastic or plasmablastic, sometimes the plasmacytoid cell can be seen and the neoplastic cell had mature plasma cell phenotype, the pathologic diagnosis of the lymphoma is still controversial now. Differentiate with plasma cell neoplasm is difficult, it is necessary to accumulate more cases for advanced study and observation in the future.
authors.affiliation: Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Li
authors.forename: Wenshuang
authors.initials: W
authors.lastname: Ding
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zuo
authors.forename: Ning
authors.initials: N
authors.lastname: Geng
authors.forename: Huai
authors.initials: H
authors.lastname: Yang
authors.forename: Xiulan
authors.initials: X
authors.lastname: Liu
authors.forename: Jianchao
authors.initials: J
authors.lastname: Wang
authors.forename: Wenqing
authors.initials: W
authors.lastname: Yao
authors.forename: Weiping
authors.initials: W
authors.lastname: Liu
mesh_terms: D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma; D010950:Plasma Cells; D000069293:Plasmablastic Lymphoma / Q000175:diagnosis* / Q000473:pathology*; D012367:RNA, Viral / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: C099537:Epstein-Barr virus encoded RNA 1; C106732:Epstein-Barr virus encoded RNA 2; D012367:RNA, Viral