title: Enhanced solubilization of curcumin in mixed surfactant vesicles.
abstract: Self-assemblies of equimolar double and single chain mixed ionic surfactants, with increasing numbers of carbon atoms of double chain surfactant, were analyzed on the basis of fluorescence and conductivity results. Attempts were also made to enhance the solubilization of curcumin in aqueous equimolar mixed surfactant systems. Mixed surfactant assembly was successful in retarding the degradation of curcumin in alkaline media (only 25-28 40% degraded in 10h at pH 13). Fluorescence spectroscopy and fluorescence quenching methods were employed to predict the binding position and mechanism of curcumin with self-assemblies. Results indicate that the interactions take place according to both dynamic and static quenching mechanisms and curcumin was distributed in a palisade layer of mixed aggregates. Antioxidant activity (using DPPH radical) and biocompatibility (using calf-thymus DNA) of curcumin-loaded mixed surfactant formulations were also evaluated. The prepared systems improved the stability, solubility and antioxidant activity of curcumin and additionally are biocompatible.
authors.affiliation: Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160 014, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160 014, India.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Dr. SSB University Institute of Chemical Engineering & Technology, Panjab University, Chandigarh 160 014, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Kansal
authors.affiliation: Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160 014, India.
authors.forename: Ganga Ram
authors.initials: GR
authors.lastname: Chaudhary
authors.affiliation: Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160 014, India. Electronic address: skmehta@pu.ac.in.
authors.forename: S K
authors.initials: SK
authors.lastname: Mehta
mesh_terms: D000975:Antioxidants; D003474:Curcumin / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000975:Antioxidants; D013501:Surface-Active Agents; D014867:Water; D003474:Curcumin
keywords: Antioxidant; Curcumin solubility and stability; Mixed surfactants; ct-DNA interaction