title: Prognostic value of gasometric parameters of carbon dioxide in resuscitation of septic patients. A bibliography review.
abstract: The anaerobic metabolism is the cornerstone in physiopathology of septic shock. Nowadays we have both the central or mixed venous oxygen saturation and lactate levels to monitoring the metabolism in septic patients. Some studies have shown that normalization of systemic hemodynamic and oxygen metabolism variables not prevent progression to multiorgan damage and death. Recently has been proposed the venous-to-arterial carbon dioxide difference (ΔpvaCO2) as an alternative marker of tissue hypoperfusion, like Cardiac Index. High ΔpvaCO2 predicts adverse outcomes. Also has been proposed both, the ratio between the ΔpvaCO2 and arterial-to-venous oxygen content difference (ΔCavO2): ΔpvaCO2/ΔCavO2; and, the ratio between venous-to-arterial carbon dioxide difference (ΔCvaCO2) and ΔCavO2: ΔCvaCO2/ΔCavO2, as markers of anaerobic metabolism. Both of high ratios are related to high levels of lactate and worse prognosis. Therefore in patients with sepsis the combination of markers of resuscitation could be important to improve the outcomes.
authors.affiliation: Servicio de Anestesiología y Cuidados Críticos, Hospital Sierrallana, Servicio Cántabro de Salud, Torrelavega, Cantabria, España. Electronic address: joseangel.lamsfus@scsalud.es.
authors.forename: J Á
authors.initials: JÁ
authors.lastname: Lamsfus-Prieto
authors.affiliation: Servicio de Anestesiología y Cuidados Críticos, Hospital Sierrallana, Servicio Cántabro de Salud, Torrelavega, Cantabria, España.
authors.forename: R
authors.initials: R
authors.lastname: de Castro-Fernández
authors.affiliation: Servicio de Anestesiología y Cuidados Críticos, Hospital Sierrallana, Servicio Cántabro de Salud, Torrelavega, Cantabria, España.
authors.forename: A M
authors.initials: AM
authors.lastname: Hernández-García
authors.affiliation: Servicio de Anestesiología y Cuidados Críticos, Hospital Sierrallana, Servicio Cántabro de Salud, Torrelavega, Cantabria, España.
authors.forename: G
authors.initials: G
authors.lastname: Marcano-Rodriguez
mesh_terms: D001784:Blood Gas Analysis; D002245:Carbon Dioxide; D006801:Humans; D011379:Prognosis; D012151:Resuscitation; D012772:Shock, Septic
chemical_list: D002245:Carbon Dioxide
keywords: Análisis de los gases de la sangre; Blood gas analysis; Carbon dioxide; Consumo de oxígeno; Dióxido de carbono; Evaluación del resultado de la atención al paciente; Lactic acid; Oxygen consumption; Patient outcome assessment; Septic shock; Shock séptico; Ácido láctico