title: A randomised double-blind placebo-controlled trial comparing stepwise oral misoprostol with vaginal misoprostol for induction of labour.
abstract: A comparison of induction of labour (IOL) using three doses of 25 µg vaginal misoprostol inserted at intervals of 4 h or more with a stepwise oral regime starting with 50 µg followed by two doses of 100 µg was studied in a double-blind placebo-controlled trial in a tertiary centre in South India. Primary outcome was vaginal delivery in 24 h. Significantly more women in the first group required oxytocin augmentation and a third dose of the drug than women in the second group. Uterine tachysystole and other maternal and neonatal complications were similar. Thus it is concluded that women induced with oral, as compared to vaginal misoprostol are more likely to labour without oxytocin.
authors.affiliation: Registrar, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Hilda
authors.initials: H
authors.lastname: Yenuberi
authors.affiliation: Assistant Professor, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Anuja
authors.initials: A
authors.lastname: Abraham
authors.affiliation: Assistant Professor, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Ajit
authors.initials: A
authors.lastname: Sebastian
authors.affiliation: Associate Professor, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Santosh J
authors.initials: SJ
authors.lastname: Benjamin
authors.affiliation: Lecturer, Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Visalakshi
authors.initials: V
authors.lastname: Jeyaseelan
authors.affiliation: Professor, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India coronistrial@yahoo.co.in.
authors.forename: Jiji E
authors.initials: JE
authors.lastname: Mathews
mesh_terms: D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D036861:Delivery, Obstetric; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007194:India; D007751:Labor, Induced / Q000379:methods*; D016595:Misoprostol / Q000008:administration & dosage*; D010120:Oxytocics / Q000008:administration & dosage*; D011247:Pregnancy; D011256:Pregnancy Outcome; D013997:Time Factors; D016896:Treatment Outcome; D014599:Uterus / Q000187:drug effects*
chemical_list: D010120:Oxytocics; D016595:Misoprostol
keywords: Oral; induction; misoprostol; oxytocin; tachysystole; vaginal