title: [What's new in clinical dermatology?].
abstract: Significant advances have been performed in cutaneous adverse reactions leading to primary prevention strategy and implication of new signaling pathways. Histological features of DRESS and methotrexate toxicity are detailed. New emerging infectious agents are reported including Zika Virus, an arbovirus which can be confused with dengue or chikungunya, a new cowpox virus transmitted by domestic cat leading to lymphadenitis, Spirurina type X larva transmitted in Japan by eating raw squid or fish. Malignancies in pemphigus and pemphigoid are emphasized. Expert recommandations are developped on definitions, diagnosis and disease activity of mucous membrane pemphigoid, bubllous pemphigoid and pemphigus. Psoriasis and cardiometabolic association are discussed. This risk association appears higher in hidradenitis suppurativa, which seems more frequent in patients of African ancestry. IgG4-related disease is an immune mediated entity characterized by fibroinflammatory lesions often misdiagnosed. Pruritus, heat sensations, numbness could be recognized as a small-fiber neuropathy symptoms. Burden impact in common dermatosis is demonstrated and should be integrated in our daily practice.
authors.affiliation: Service de dermatologie, centre de référence des maladies bulleuses immunologiques et toxiques, AP-HP, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil Cedex ; université Paris-Est Créteil, Créteil, France. Electronic address: laurence.allanore@hmn.aphp.fr.
authors.forename: L
authors.initials: L
authors.lastname: Valeyrie-Allanore
mesh_terms: D006801:Humans; D012871:Skin Diseases
keywords: Agents infectieux émergeants; Burden; Drug adverse reaction; Emerging infectious agents; Fardeau; Hidradenitis suppurativa; IgG4-related disease; Maladie de Verneuil; Maladie à IgG4; Neuropathie des petites fibres; Pemphigoid; Pemphigoïde; Psoriasis; Small-fiber neuropathy; Toxidermies