title: Early Degeneration of Extracellular Matrix Used for Aortic Reconstruction During the Norwood Operation.
abstract: The use of prosthetic patch material is often required during the surgical reconstruction of complex congenital cardiac malformations. Decellularized porcine small intestinal submucosa, a type of extracellular matrix, was recently introduced as a patch for cardiac and vascular tissue repair. Extracellular matrix was used for aortic reconstruction during the Norwood procedure in 8 consecutive neonates with hypoplastic left heart syndrome. Rapid degeneration or aneurysm formation developed in 3 of these patients who came to second-stage surgery. Extracellular matrix should be used cautiously for aortic reconstruction in infants until additional reports from other centers provide confirmation of its safety.
authors.affiliation: Acibadem University, Medical Faculty, Acibadem Atakent Hospital, Halkali, Istanbul, Turkey. Electronic address: ersinerek@hotmail.com.
authors.forename: Ersin
authors.initials: E
authors.lastname: Erek
authors.affiliation: Acibadem University, Medical Faculty, Acibadem Atakent Hospital, Halkali, Istanbul, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Acibadem University, Medical Faculty, Acibadem Atakent Hospital, Halkali, Istanbul, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Suzan
authors.affiliation: Acibadem University, Medical Faculty, Acibadem Atakent Hospital, Halkali, Istanbul, Turkey.
authors.forename: Okan
authors.initials: O
authors.lastname: Yildiz
authors.affiliation: Acibadem University, Medical Faculty, Acibadem Atakent Hospital, Halkali, Istanbul, Turkey.
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Demir
authors.affiliation: Acibadem University, Medical Faculty, Acibadem Atakent Hospital, Halkali, Istanbul, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Odemis
mesh_terms: D000818:Animals; D001011:Aorta / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000209:etiology; D001705:Bioprosthesis / Q000009:adverse effects; D005109:Extracellular Matrix / Q000637:transplantation*; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000601:surgery*; D007231:Infant, Newborn; D058327:Norwood Procedures; D011183:Postoperative Complications / Q000209:etiology; D011475:Prosthesis Failure; D013552:Swine; D013997:Time Factors; D014656:Vascular Surgical Procedures / Q000379:methods