title: Regulatory T Cell Immunotherapy in Immune-Mediated Diseases.
abstract: Broad clinical interest rapidly followed the recent discovery of different subpopulations of T cells that have immune regulatory properties and a number of studies have been conducted aiming to dissect the translational potential of these promising cells. In this review we will focus on forkhead box P3 (FoxP3) positive regulatory T cells, T regulatory type 1 cells and invariant natural killer T cells (iNKT). We will analyze their ability to correct immune dysregulation in animal models of immune mediated diseases and we will examine the first clinical approaches where these cells have been directly or indirectly employed. We will discuss successes, challenges and limitations that rose in the road to the clinical use of regulatory T cells.
authors.affiliation: Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA; Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pierini
authors.affiliation: Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine II, Eberhard Karls University, Tübingen, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Schneidawind
authors.affiliation: Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA; Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nishikii
authors.affiliation: Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Negrin
keywords: FoxP3+ T regulatory cells; Graft versus Host Disease; Hematopoietic Stem Cell Transplantation; Invariant Natural Killer T cells; T regulatory type 1 cells; Tolerance Induction