title: Management of NSAID-associated peptic ulcer disease.
abstract: Non-steroidal anti-inflammatory drug (NSAID) use increases the risk of gastrointestinal complications such as ulcers or bleeding. The presence of factors like advanced age, history of peptic ulcer, Helicobacter pylori infection and the use of anticoagulants or antiplatelet agents increase this risk further. COX-2 inhibitors and antisecretory drugs, particularly proton pump inhibitors, help to minimize the risk of gastrointestinal complications in high-risk patients. This review presents a practical approach to the prevention and treatment of NSAID-associated peptic ulcer disease and examines the new advances in the rational use of NSAIDs.
authors.affiliation: a Unidad de Gastroenterología, Servicio de Digestivo , Corporació Sanitària Parc Taulí , Sabadell , Spain.
authors.forename: Luigi
authors.initials: L
authors.lastname: Melcarne
authors.affiliation: a Unidad de Gastroenterología, Servicio de Digestivo , Corporació Sanitària Parc Taulí , Sabadell , Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: García-Iglesias
authors.affiliation: a Unidad de Gastroenterología, Servicio de Digestivo , Corporació Sanitària Parc Taulí , Sabadell , Spain.|b Departament de Medicina , Universitat Autònoma de Barcelona , Sabadell , Spain.|c CIBERehd , Instituto Carlos III , Madrid , Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Calvet
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D016481:Helicobacter Infections / Q000188:drug therapy / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects / Q000472:pathogenicity; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors
keywords: COX-2 selective inhibitors; Cardiovascular risk; Gastrointestinal bleeding; Gastrointestinal risk; Gastroprotection; Low dose aspirin; NSAID gastropathy; Non-steroidal anti-inflammatory drugs; Upper gastrointestinal complications