title: [Relationship between macrophages and erythropoiesis].
abstract: Macrophages have two major roles in regulating the dynamic equilibrium in erythropoiesis, promoting the differentiation and maturation of nucleated red blood cells into reticulocytes and removing old red blood cells. A recent mouse study has demonstrated that the phenotype of macrophages in erythroblastic islands is CD169+ VCAM-1+ ER-HR3+ CD11b+ F4/80+ Ly-6G+. Molecular connections between erythroid progenitor cells and central macrophages help to maintain the function and integrity of erythroblastic islands. New research advances in Kruppel-like factor 1 (KLF1) provide new evidence for the important role of macrophages in erythroblastic islands. Macrophages play an important role in erythropoiesis both in sickness and in health, and provide a potential targeted therapy for diseases such as polycythemia vera and beta-thalassemia in the future.
authors.affiliation: Diagnosis and Treatment Center of Pediatric Blood Diseases, Institute of Hematology and Blood Disease Hospital, Pecking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300020, China. xfzhu1981@126.com.
authors.forename: Ran-Ran
authors.initials: RR
authors.lastname: Zhang
authors.forename: Xiao-Fan
authors.initials: XF
authors.lastname: Zhu
mesh_terms: D000818:Animals; D004920:Erythropoiesis; D006801:Humans; D039041:Integrin alpha4beta1 / Q000502:physiology; D051741:Kruppel-Like Transcription Factors / Q000502:physiology; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D010641:Phenotype; D019010:Vascular Cell Adhesion Molecule-1 / Q000502:physiology
chemical_list: D039041:Integrin alpha4beta1; D051741:Kruppel-Like Transcription Factors; D019010:Vascular Cell Adhesion Molecule-1; C080774:erythroid Kruppel-like factor