title: [Evaluation of the efficacy of a new nutraceutical product in the treatment of postmenopausal symptoms].
abstract: The onset of vasomotor symptoms in postmenopausal women represents the beginning of a hard period from the emotional point of view which involves some of the most important neurotransmitters. Hot flushes and insomnia associated with a state of anxiety that affect postmenopausal women are included in an index known as the Kupperman Index. The use of nutraceuticals in Italy is increasingly widespread, and only 6-8% of women currently choose to take hormone replacement therapy. The action of these natural supplements primarily depends on the selection of substances and the dose of each single ingredient. Moreover, it also depends on the range of vasomotor symptoms (from mild to moderate/severe). The aim of this study was to test the action of a new product without phytoestrogens containing Cimicifuga racemosa, chasteberry (Vitex agnus-castus), hyaluronic acid, zinc and ginger (ElleN®) in two different groups of women: one with mild and the other with moderate/severe menopausal symptoms. All women received a dose of one tablet per day of ElleN® for three months. Results showed a significant reduction in the Kupperman Index in both groups. The treatment was particularly effective against hot flushes associated with night insomnia and anxiety. The product was well tolerated, did not cause any side effects, and none of the subjects dropped out of the study. In conclusion, it can be stated that the supplement evaluated in the present study is able to reduce moderate/severe menopause symptoms.
authors.affiliation: Ginecologia e Ostetricia, Dipartimento di Medicina Molecolare e dello Sviluppo,Policlinico Le Scotte, Università degli Studi di Siena, Siena, Italia - vincenzo.deleo@unisi.it.
authors.forename: V
authors.initials: V
authors.lastname: Cappelli
authors.forename: G
authors.initials: G
authors.lastname: Morgante
authors.forename: A
authors.initials: A
authors.lastname: Di Sabatino
authors.forename: M G
authors.initials: MG
authors.lastname: Massaro
authors.forename: V
authors.initials: V
authors.lastname: De Leo
mesh_terms: D000368:Aged; D019587:Dietary Supplements; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007558:Italy; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D017698:Postmenopause; D011446:Prospective Studies; D012720:Severity of Illness Index; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts