title: Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
abstract: BACKGROUND
  Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by repeated skin exposure to contact allergens. The goal of this pilot study was to identify inflammatory proteins which can serve as biomarkers for ACD.
  
  
  METHODS
  We measured levels of 102 cytokines, chemokines, and growth factors in the sera of 16 ACD patients during acute and remission phases, and 16 healthy volunteers.
  
  
  RESULTS
  Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls. In ACD patients, serum levels of CCL5 were elevated, whereas levels of TFF3, soluble intercellular adhesion molecule-1 (sICAM-1), and platelet-derived growth factor (PDGF)-AB/BB were found to be lower during the remission phase of the disease.
  
  
  CONCLUSIONS
  Serum levels of adiponectin, CCL5, CRP, CHI3L1, CFD, endoglin, lipocalin-2, osteopontin, RBP4, PF4, and TFF3 might be exploited as biomarkers for ACD, whereas levels of CCL5, TFF3, sICAM-1, and PDGF-AB/BB might be exploited for evaluation of disease progression and efficacy of ACD treatment.
authors.affiliation: Department of Immunology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
authors.forename: Auksė
authors.initials: A
authors.lastname: Zinkevičienė
authors.forename: Denis
authors.initials: D
authors.lastname: Kainov
authors.forename: Eglė
authors.initials: E
authors.lastname: Lastauskienė
authors.forename: Violeta
authors.initials: V
authors.lastname: Kvedarienė
authors.forename: Dmitrii
authors.initials: D
authors.lastname: Bychkov
authors.forename: Myles
authors.initials: M
authors.lastname: Byrne
authors.forename: Irutė
authors.initials: I
authors.lastname: Girkontaitė
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D018925:Chemokines / Q000097:blood; D016207:Cytokines / Q000097:blood; D017449:Dermatitis, Allergic Contact / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins