title: Ferumoxytol-Enhanced Magnetic Resonance Imaging in Late-Stage CKD.
abstract: Ferumoxytol is a superparamagnetic iron oxide particle encapsulated by a semisynthetic carbohydrate with properties that can be used by the nephrologist for diagnosis and therapy. Ferumoxytol is approved by the US Food and Drug Administration for treating iron deficiency anemia in the setting of chronic kidney disease, but not for clinical diagnostic imaging. It has gained appeal as a magnetic resonance imaging contrast agent in patients with estimated glomerular filtration rates < 30mL/min/1.73m(2) in whom gadolinium-based contrast magnetic resonance imaging agents are relatively contraindicated because of the association with gadolinium deposition and nephrogenic systemic fibrosis. Ferumoxytol metabolism is not dependent on kidney function, but rather is removed from the circulation by the reticuloendothelial system of the liver, spleen, and bone marrow. Additionally, the prolonged intravascular half-life (>14 hours) of ferumoxytol allows for longer image acquisition and repeat imaging, if necessary. In patients with contraindications for gadolinium contrast agents, ferumoxytol is an alternative agent for vascular assessment, including patency and course.
authors.affiliation: Brigham and Women's Hospital, Boston, MA.
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Mukundan
authors.affiliation: Brigham and Women's Hospital, Boston, MA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Steigner
authors.affiliation: Brigham and Women's Hospital, Boston, MA.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Hsiao
authors.affiliation: Brigham and Women's Hospital, Boston, MA.
authors.forename: Sayeed K
authors.initials: SK
authors.lastname: Malek
authors.affiliation: Brigham and Women's Hospital, Boston, MA.
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Tullius
authors.affiliation: Geisinger Wyoming Valley Medical Center, Wilkes-Barre, PA.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Chin
authors.affiliation: Brigham and Women's Hospital, Boston, MA. Electronic address: asiedlecki@bwh.harvard.edu.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Siedlecki
mesh_terms: D000328:Adult; D003287:Contrast Media; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011856:Radiographic Image Enhancement; D051436:Renal Insufficiency, Chronic / Q000000981:diagnostic imaging*; D012720:Severity of Illness Index
chemical_list: D003287:Contrast Media; D052203:Ferrosoferric Oxide
keywords: Ferumoxytol; chronic kidney disease (CKD); contrast agent; magnetic resonance angiography (MRA); magnetic resonance imaging (MRI); renal failure; ultra-small superparamagnetic iron oxide (USPIO)