title: Comparison of fetuin-A and transforming growth factor beta 1 levels in patients with spondyloarthropathies and rheumatoid arthritis.
abstract: OBJECTIVE
  We investigated the serum transforming growth factor beta 1 (TGFβ1) and fetuin-A levels, and determined the relationships between these biomarkers and disease activity, mobility and radiologic progression in patients with spondyloarthropathy (SpA) and rheumatoid arthritis (RA).
  
  
  METHODS
  The study included 55 patients with SpA and 38 patients with RA, together with 28 healthy subjects. In AS patients, we assessed disease activity using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional ability using the Bath Ankylosing Spondylitis Functional Index (BASFI), and mobility using the Bath Ankylosing Spondylitis Metrology Index (BASMI), radiologic progression using the Bath Ankylosing Spondylitis Radiology Index (BASRI). Serum fetuin-A and TGFβ1 were determined using enzyme-linked immunosorbent assay (ELISA) equipment.
  
  
  RESULTS
  Fetuin-A was significantly higher in the axial SpA and RA groups than in healthy subjects (P < 0.01). Serum TGFβ1 and fetuin-A levels were similar in the peripheral SpA group and in healthy subjects. A significant positive correlation was found between the fetuin-A and TGFβ1 levels in the axial SpA, peripheral SpA, and RA groups (r = 0.293, P = 0.009; r = 0.215, P = 0.04; r = 0.223, P = 0.05, respectively). Significant correlations were found between fetuin-A and the BASMI and BASRI values in the axial SpA patients (r = 0.444, P = 0.031; r = 0.486, P < 0.001, respectively).
  
  
  CONCLUSIONS
  We conclude that Fetuin-A may be one of the steps that can be active in disease progression in axial SpA patients.
authors.affiliation: Divison of Rheumatology, Department of Pysical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Harman
authors.affiliation: Divison of Rheumatology, Department of Pysical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Tekeoğlu
authors.affiliation: Department of Medical Physiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: Gönül
authors.initials: G
authors.lastname: Gürol
authors.affiliation: Divison of Rheumatology, Department of Pysical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: Mustafa Serdar
authors.initials: MS
authors.lastname: Sağ
authors.affiliation: Department of Microbiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Karakeçe
authors.affiliation: Department of Microbiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: İhsan Hakkı
authors.initials: İH
authors.lastname: Çİftçİ
authors.affiliation: Divison of Rheumatology, Department of Pysical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Kamanlı
authors.affiliation: Divison of Rheumatology, Department of Pysical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Nas
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000000981:diagnostic imaging; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D012042:Registries; D012720:Severity of Illness Index; D025242:Spondylarthropathies / Q000097:blood* / Q000000981:diagnostic imaging; D011795:Surveys and Questionnaires; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis*
chemical_list: C556354:AHSG protein, human; D015415:Biomarkers; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; D060749:alpha-2-HS-Glycoprotein
keywords: fetuin A; new bone formation; rheumatoid arthritis; spondyloarthropathies; transforming growth factor beta 1