title: Separate circuitries encode the hedonic and nutritional values of sugar.
abstract: Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of sugar. During sugar intake, suppressing hedonic value inhibited dopamine release in ventral, but not dorsal, striatum, whereas suppressing nutritional value inhibited dopamine release in dorsal, but not ventral, striatum. Consistently, cell-specific ablation of dopamine-excitable cells in dorsal, but not ventral, striatum inhibited sugar's ability to drive the ingestion of unpalatable solutions. Conversely, optogenetic stimulation of dopamine-excitable cells in dorsal, but not ventral, striatum substituted for sugar in its ability to drive the ingestion of unpalatable solutions. Our data indicate that sugar recruits a distributed dopamine-excitable striatal circuitry that acts to prioritize energy-seeking over taste quality.
authors.affiliation: The John B. Pierce Laboratory, New Haven, Connecticut, USA.|Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Tellez
authors.affiliation: The John B. Pierce Laboratory, New Haven, Connecticut, USA.|Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Wenfei
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: The John B. Pierce Laboratory, New Haven, Connecticut, USA.|Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.|Mathematics, Computing and Cognition Center, Federal University of ABC, Santo André SP, Brazil.
authors.forename: Tatiana L
authors.initials: TL
authors.lastname: Ferreira
authors.affiliation: The John B. Pierce Laboratory, New Haven, Connecticut, USA.
authors.forename: Isaac O
authors.initials: IO
authors.lastname: Perez
authors.affiliation: Department of Physiology and Biophysics, Biomedical Sciences Institute, University of São Paulo, São Paulo SP, Brazil.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Shammah-Lagnado
authors.affiliation: Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Anthony N
authors.initials: AN
authors.lastname: van den Pol
authors.affiliation: The John B. Pierce Laboratory, New Haven, Connecticut, USA.|Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.|Department of Physiology, Yale University School of Arts and Sciences, New Haven, Connecticut, USA.
authors.forename: Ivan E
authors.initials: IE
authors.lastname: de Araujo
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D051379:Mice; D009753:Nutritive Value / Q000502:physiology*; D062308:Optogenetics; D057181:Pleasure / Q000187:drug effects / Q000502:physiology*; D013395:Sucrose / Q000031:analogs & derivatives / Q000494:pharmacology; D055697:Taste Perception / Q000187:drug effects / Q000502:physiology*
chemical_list: D013395:Sucrose; C026285:trichlorosucrose; D005947:Glucose; D004298:Dopamine