title: Photodynamic Therapy in Non-Gastrointestinal Thoracic Malignancies.
abstract: Photodynamic therapy has a role in the management of early and late thoracic malignancies. It can be used to facilitate minimally-invasive treatment of early endobronchial tumours and also to palliate obstructive and bleeding effects of advanced endobronchial tumours. Photodynamic therapy has been used as a means of downsizing tumours to allow for resection, as well as reducing the extent of resection necessary. It has also been used successfully for minimally-invasive management of local recurrences, which is especially valuable for patients who are not eligible for radiation therapy. Photodynamic therapy has also shown promising results in mesothelioma and pleural-based metastatic disease. As new generation photosensitizers are being developed and tested and methodological issues continue to be addressed, the role of photodynamic therapy in thoracic malignancies continues to evolve.
authors.affiliation: Division of Thoracic Surgery, University of Toronto, Toronto, ON M5G 2C4, Canada. b.kidane@mail.utoronto.ca.|Division of Thoracic Surgery, Toronto General Hospital, Toronto, ON M5G 2C4, Canada. b.kidane@mail.utoronto.ca.
authors.forename: Biniam
authors.initials: B
authors.lastname: Kidane
authors.affiliation: Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. dhruvinh@gmail.com.
authors.forename: Dhruvin
authors.initials: D
authors.lastname: Hirpara
authors.affiliation: Division of Thoracic Surgery, University of Toronto, Toronto, ON M5G 2C4, Canada. kazuhiro.yasufuku@uhn.ca.|Division of Thoracic Surgery, Toronto General Hospital, Toronto, ON M5G 2C4, Canada. kazuhiro.yasufuku@uhn.ca.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yasufuku
mesh_terms: D000368:Aged; D000402:Airway Obstruction / Q000188:drug therapy* / Q000473:pathology; D001999:Bronchoscopy; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000556:secondary; D013899:Thoracic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents
keywords: airway obstruction; bronchial obstruction; mesothelioma; non-small cell lung cancer; photodynamic therapy; pleural metastasis; thoracic malignancy