title: Amide α,β-Dehydrogenation Using Allyl-Palladium Catalysis and a Hindered Monodentate Anilide.
abstract: A practical and direct method for the α,β-dehydrogenation of amides is reported using allyl-palladium catalysis. Critical to the success of this process was the synthesis and application of a novel lithium N-cyclohexyl anilide (LiCyan). The reaction conditions tolerate a wide variety of substrates, including those with acidic heteroatom nucleophiles.
authors.affiliation: Department of Chemistry, Yale University , 275 Prospect Street, New Haven, Connecticut 06520-8107, United States.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Yale University , 275 Prospect Street, New Haven, Connecticut 06520-8107, United States.
authors.forename: Aneta
authors.initials: A
authors.lastname: Turlik
authors.affiliation: Department of Chemistry, Yale University , 275 Prospect Street, New Haven, Connecticut 06520-8107, United States.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Newhouse