title: Lung transplantation for pulmonary sarcoidosis. Twenty-five years of experience in the USA.
abstract: OBJECTIVE
  Lung transplantation is the ultimate treatment for end-stage pulmonary sarcoidosis. Post-transplant survival outcomes remain unclear.
  
  
  METHODS
  Survival models were used to assess survival and graft outcomes in patients with sarcoid among 20,896 lung transplants performed in the USA.
  
  
  RESULTS
  695 lung recipients were transplanted for pulmonary sarcoidosis. Sarcoid lung recipients had similar median survival rate (69.7 months (IQR 60.2-79.3)) compared with the non-sarcoid lung recipients (63.1 months (IQR 61.4-64.8), p=0.88). In multivariate Cox regression, sarcoidosis was not independently associated with worse mortality (HR 0.96 (95% CI 0.85 to 1.08), p=0.51). Among the sarcoid lung recipients, double lung transplantation (HR 0.76 (0.58 to 0.99), p=0.04) and lung allocation score era (HR 0.74 (0.56 to 0.97), p=0.03) were associated with improved survival.
  
  
  CONCLUSIONS
  Recipients of lung transplants for pulmonary sarcoidosis had similar outcomes compared with non-sarcoid lung recipients.
authors.affiliation: Lillehei Heart Institute, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA.
authors.forename: Ziad
authors.initials: Z
authors.lastname: Taimeh
authors.affiliation: Department of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA.
authors.forename: Marshall I
authors.initials: MI
authors.lastname: Hertz
authors.affiliation: Department of Cardiothoracic Surgery, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Shumway
authors.affiliation: Lillehei Heart Institute, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Pritzker
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation / Q000401:mortality / Q000706:statistics & numerical data; D008297:Male; D012189:Retrospective Studies; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*; D016896:Treatment Outcome; D014481:United States
keywords: Lung Transplantation; Sarcoidosis