title: Skin compatibility and efficacy of a cosmetic skin care regimen with licochalcone A and 4-t-butylcyclohexanol in patients with rosacea subtype I.
abstract: BACKGROUND
  Patients with rosacea often show facial sensitivity to cosmetics or skin care products that can influence the severity of symptoms and exacerbate erythema and inflammation. Nevertheless, special skin care is necessary to address cosmetic concerns and reduce the potential side-effects of topical or oral treatment of the disease. Appropriate skin care should comprise gentle cleansing, effective moisturization, soothing actives, UV protection and concealing pigments to help neutralize the appearance of redness.
  
  
  OBJECTIVE
  To determine the compatibility and efficacy of a skin care regimen (consisting of a cleanser, a day care with SPF25 and a night care) containing licochalcone A (Lic A), an anti-irritant from the licorice plant Glycyrrhiza inflata, and 4-t-butylcyclohexanol (SymSitive(®) ), a substance which acts as a sensitivity regulator, in female subjects with clinically determined subtype I rosacea.
  
  
  METHODS
  Thirty-two test subjects with mild to moderate rosacea used the skin care regimen daily for 8 weeks. Clinical assessment of erythema, subjective irritation and clinical photography were performed at baseline and after 4 and 8 weeks. Additionally, a quality-of-life questionnaire was filled out by the test subjects at baseline and week 8. The subjects completed a self-assessment questionnaire on product properties after 4 and 8 weeks of product use.
  
  
  RESULTS
  Clinical assessments and subject response confirmed very good tolerability of the regimen, a statistically significant improvement in clinical grading for erythema and tactile roughness at weeks 4 and 8 and on telangiectasia at week 8 when compared to baseline scores. A statistically significant improvement in facial redness (a*) values, based on the L*a*b* colorimetric system, was determined at week 4 and 8 in comparison to baseline. No difference in corneometric measurement was detected at week 4 and 8 compared to baseline.
  
  
  CONCLUSIONS
  The skin care regimen was found to be highly compatible with the sensitive facial skin of patients with rosacea subtype I and effective in improving signs of rosacea. Therefore, the daily use of skin care products containing LicA and SymSitive(®) in patients with rosacea improves the overall skin appearance and the quality of life of these patients.
authors.affiliation: Beiersdorf AG, Hamburg, Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Schoelermann
authors.affiliation: Beiersdorf Inc., Wilton, CT, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Weber
authors.affiliation: Beiersdorf Inc., Wilton, CT, USA.
authors.forename: C
authors.initials: C
authors.lastname: Arrowitz
authors.affiliation: TJ Stephens & Associates, Colorado Springs, CO, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Rizer
authors.affiliation: TJ Stephens & Associates, Colorado Springs, CO, USA.
authors.forename: K
authors.initials: K
authors.lastname: Qian
authors.affiliation: TJ Stephens & Associates, Colorado Springs, CO, USA.
authors.forename: M
authors.initials: M
authors.lastname: Babcock
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D047188:Chalcones / Q000627:therapeutic use*; D003511:Cyclohexanols / Q000627:therapeutic use*; D003902:Detergents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004890:Erythema / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011788:Quality of Life; D012393:Rosacea / Q000188:drug therapy*; D012720:Severity of Illness Index; D017592:Skin Care / Q000379:methods*; D063465:Skin Cream / Q000627:therapeutic use; D013473:Sunscreening Agents / Q000627:therapeutic use; D011795:Surveys and Questionnaires; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors; D013684:Telangiectasis / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D047188:Chalcones; D003511:Cyclohexanols; D003902:Detergents; D013473:Sunscreening Agents; D050916:TRPV Cation Channels; C070840:licochalcone A; C557786:4-tert-butylcyclohexanol