title: Pasireotide for the treatment of acromegaly.
abstract: BACKGROUND
  Acromegaly is a chronic disease with high morbidity and enhanced mortality if left untreated. Treatment options include surgery, medical therapy (somatostatin analogues (SA), dopamine agonists (DA) and growth hormone receptor antagonists) and radiotherapy. Despite these treatment options, "real-life" studies have shown that approximately 50% of patients are not controlled. In this scenario, a next-generation SA, pasireotide, has recently been approved for the treatment of acromegaly.
  
  
  METHODS
  1) pasireotide's pharmacokinetics and pharmacodynamics; 2) pasireotide's anti-secretory and anti-proliferative effects, from preclinical studies up to phase III clinical trials; and 3) the adverse effects of pasireotide, focusing on hyperglycemia; 4) biomarkers of response to SA treatment.
  
  
  CONCLUSIONS
  surgery is the primary treatment for most patients with acromegaly; however, approximately half of them will need adjuvant therapy. At present, the decision of this adjuvant treatment is made on a "trial-and-error" fashion. Nevertheless, in recent years, efforts have been made to establish biomarkers for the response to drugs involved in the treatment of acromegaly, which will change the treatment of acromegaly towards a more personalized therapeutic decision-making process. In the near future, the establishment of pasireotide response biomarkers will allow us to identify good candidates for first-line medical monotherapy with pasireotide.
authors.affiliation: a Neuroendocrinology Research Center/Endocrine Section - Medical School and Hospital Universitário Clementino Fraga Filho , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.|b Neuroendocrine Unit , Instituto Estadual do Cérebro Paulo Niemeyer , Rio de Janeiro , Brasil.
authors.forename: Luiz Eduardo
authors.initials: LE
authors.lastname: Wildemberg
authors.affiliation: a Neuroendocrinology Research Center/Endocrine Section - Medical School and Hospital Universitário Clementino Fraga Filho , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.|b Neuroendocrine Unit , Instituto Estadual do Cérebro Paulo Niemeyer , Rio de Janeiro , Brasil.
authors.forename: Mônica R
authors.initials: MR
authors.lastname: Gadelha
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000188:drug therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000150:complications / Q000188:drug therapy; D006801:Humans; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000150:complications / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D013004:Somatostatin; C517782:pasireotide
keywords: acromegaly; acromegaly treatment; pasireotide; somatostatin analogues