title: [Current status of drug treatment against the disease caused by the Ebola virus].
abstract: The recent epidemic of disease caused by the Ebola virus has highlighted the need to develop specific drugs and have to deal with this entity. According to virological analysis they have been designed to give you some new drugs and are proven to others might be effective against this virus. The main lines of therapy are based on immunotherapy (convalescent serum of patients and specific monoclonal antibodies), antiviral drugs (favipiravir, BCX4430, brincidofovir), interfering RNAs (TKM-Ebola) and antisense oligonucleotides (morpholino phosphorodiamidate) and other drugs no antiviral (clomiphene NSC62914, FGI-103, amiloride and ouabain). Existing studies are scarce and mainly in animal models and clinical trials have been inconclusive most by the drastic reduction in the number of new cases. However, progress has been made in the biological knowledge of Ebola virus and have been located new therapeutic targets for the future development of specific antiviral.
authors.affiliation: Jordi Reina, Unidad de Virología. Servicio de Microbiología. Hospital Universitario Son Espases. 07010 Palma de Mallorca, Spain. jorge.reina@ssib.es.
authors.forename: Jordi
authors.initials: J
authors.lastname: Reina
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004196:Disease Outbreaks; D029043:Ebolavirus / Q000187:drug effects*; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy*; D006801:Humans; D007167:Immunotherapy; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D016376:Oligonucleotides, Antisense