title: Association Between the NFKB1-94ins/del ATTG Polymorphism (rs28362491) and Coronary Artery Disease: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  Inflammation plays an important role in the pathophysiology of coronary artery disease (CAD). NF-κB is a central regulator of inflammation. Thus the aim of this study was to conduct a systematic review and meta-analysis investigating whether the polymorphism in the NFKB1 promoter region (NFKB1-94ins(I)/del(D)ATTG, rs28362491) is associated with CAD susceptibility.
  
  
  METHODS
  PubMed, Embase, Cochrane Library and CNKI databases were searched up to 30 July 2015. All observational case-control studies that investigated the association of NFKB1 I/D polymorphism and CAD risk were included. Two reviewers independently selected the studies and extracted the data.
  
  
  RESULTS
  A total of 7 studies were included in this meta-analysis. Comparison between alleles showed a 13% increased risk of CAD for D vs. I (OR = 1.13, 95% CI 1.06-1.19, PH = 0.318), and comparisons among genotypes showed a 26% increased risk of CAD for DD vs. II (OR = 1.26, 95% CI 1.12-1.43, PH = 0.125) and in the heterozygote model ID vs. II had an 11% increased risk (OR = 1.11, 95% CI 1.01-1.21, PH = 0.751). In the dominant model the risk of CAD risk was reduced by 13% (OR = 0.87, 95%CI 0.80-0.95, PH = 0.814) across the total population. Subgroup analysis by ethnicity indicated that the additive model was associated with a 21% increased risk for CAD in the Caucasian population (OR = 1.21, 95% CI 1.09-1.34, PH = 0.522), while the homozygote model gave a 47% increased risk for CAD in Asian population (OR = 1.47, 95% CI 1.21-1.78, PH = 0.314).
  
  
  CONCLUSIONS
  Our results indicated that the NFKB1-94ins/del ATTG polymorphism was associated with susceptibility to CAD in both Asian and Caucasian populations.
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|2 Xinjiang Key Laboratory of Cardiovascular Disease Research , Urumqi, China .|3 Clinical Research Institute of Xinjiang Medical University , Urumqi, China .
authors.forename: Qing-Jie
authors.initials: QJ
authors.lastname: Chen
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|4 Department of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region , Urumqi, China .
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Lai
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|2 Xinjiang Key Laboratory of Cardiovascular Disease Research , Urumqi, China .
authors.forename: Long
authors.initials: L
authors.lastname: Zhao
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|2 Xinjiang Key Laboratory of Cardiovascular Disease Research , Urumqi, China .|3 Clinical Research Institute of Xinjiang Medical University , Urumqi, China .
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|2 Xinjiang Key Laboratory of Cardiovascular Disease Research , Urumqi, China .|3 Clinical Research Institute of Xinjiang Medical University , Urumqi, China .
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|2 Xinjiang Key Laboratory of Cardiovascular Disease Research , Urumqi, China .|3 Clinical Research Institute of Xinjiang Medical University , Urumqi, China .
authors.forename: Hui
authors.initials: H
authors.lastname: Zhai
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|2 Xinjiang Key Laboratory of Cardiovascular Disease Research , Urumqi, China .|3 Clinical Research Institute of Xinjiang Medical University , Urumqi, China .
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|2 Xinjiang Key Laboratory of Cardiovascular Disease Research , Urumqi, China .|3 Clinical Research Institute of Xinjiang Medical University , Urumqi, China .
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: He
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|2 Xinjiang Key Laboratory of Cardiovascular Disease Research , Urumqi, China .
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|2 Xinjiang Key Laboratory of Cardiovascular Disease Research , Urumqi, China .
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi, China .|2 Xinjiang Key Laboratory of Cardiovascular Disease Research , Urumqi, China .|3 Clinical Research Institute of Xinjiang Medical University , Urumqi, China .
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
mesh_terms: D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human