title: Vescalagin from Pink Wax Apple [Syzygium samarangense (Blume) Merrill and Perry] Alleviates Hepatic Insulin Resistance and Ameliorates Glycemic Metabolism Abnormality in Rats Fed a High-Fructose Diet.
abstract: This study investigates the ameliorative effect of vescalagin (VES) isolated from Pink wax apple fruit on hepatic insulin resistance and abnormal carbohydrate metabolism in high-fructose diet (HFD)-induced hyperglycemic rats. The results show that in HFD rats, VES significantly reduced the values of the area under the curve for glucose in an oral glucose tolerance test and the homeostasis model assessment of insulin resistance index. VES significantly enhanced the activity of hepatic antioxidant enzymes while reducing thiobarbituric acid-reactive substances in HFD rats. Western blot assay revealed that VES reduced hepatic protein expression involved in inflammation pathways while up-regulating expression of hepatic insulin signaling-related proteins. Moreover, VES up-regulated the expression of hepatic glycogen synthase and hepatic glycolysis-related proteins while down-regulating hepatic gluconeogenesis-related proteins in HFD rats. This study suggests some therapeutic potential of VES in preventing the progression of diabetes mellitus.
authors.affiliation: Department of Food and Beverage Management, China University of Science and Technology , No. 245, Sec. 3, Academia Road, Taipei 11581, Taiwan.
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Huang
authors.affiliation: Graduate Institute of Food Science and Technology, National Taiwan University , P.O. Box 23-14, Taipei 10672, Taiwan.
authors.forename: Wen-Chang
authors.initials: WC
authors.lastname: Chang
authors.affiliation: Graduate Institute of Food Science and Technology, National Taiwan University , P.O. Box 23-14, Taipei 10672, Taiwan.
authors.forename: James Swi-Bea
authors.initials: JS
authors.lastname: Wu
authors.affiliation: Department of Human Development and Family Studies, National Taiwan Normal University , No. 162, Sec. 1, Heping East Road, Taipei 10610, Taiwan.
authors.forename: Rui-Wen
authors.initials: RW
authors.lastname: Shih
authors.affiliation: Department of Human Development and Family Studies, National Taiwan Normal University , No. 162, Sec. 1, Heping East Road, Taipei 10610, Taiwan.
authors.forename: Szu-Chuan
authors.initials: SC
authors.lastname: Shen
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism; D005632:Fructose / Q000009:adverse effects* / Q000378:metabolism; D005638:Fruit / Q000737:chemistry; D006801:Humans; D047348:Hydrolyzable Tannins / Q000008:administration & dosage*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D027842:Syzygium / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D047348:Hydrolyzable Tannins; D007328:Insulin; D010936:Plant Extracts; D005632:Fructose; C084709:vescalagin
keywords: carbohydrate metabolism; diabetes mellitus; inflammation; insulin resistance; vescalagin