title: Delayed administration IL-1β neutralizing antibody improves cognitive function after transient global ischemia in rats.
abstract: In order to study the protective effects on motor and cognitive function by inhibiting IL-1β as delayed as 24h after global ischemia, we designed behavioral testing protocol and histology detection after 10 min transient global ischemia followed by IL-1β or its antibody intracerebroventricular injection. We found benefit of IL-1β antibody treatment 24h after ischemia in cognitive function recovery. But no obvious amelioration in motor function was found. Further we detected cell morphology and survival by histology staining and proved IL-1β antibody could reduce ischemia induced cell morphological changes and cell loss in hippocampus, which related with cognitive function. Present results indicate intervening IL-1β pathway could be helpful in cognitive function recovery even as late as 24h after ischemia happens.
authors.affiliation: Department of Physiology and Pathophysiology, School of Basic Medical Science, Dali University, No. 2, Snowman Road, Dali, Yunnan 671000, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Department of Physiology, Medical School of Peking University, No. 38, Xueyuan Road, Beijing 100191, China.
authors.forename: Chang-Jiang
authors.initials: CJ
authors.lastname: Zou
authors.affiliation: Department of Physiology and Pathophysiology, School of Basic Medical Science, Dali University, No. 2, Snowman Road, Dali, Yunnan 671000, China. Electronic address: pingzhou24@163.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D057967:Infusions, Intraventricular; D053583:Interleukin-1beta / Q000008:administration & dosage* / Q000276:immunology; D002546:Ischemic Attack, Transient / Q000150:complications*; D008297:Male; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000906:Antibodies; D053583:Interleukin-1beta
keywords: Cognitive function; Delayed administration; IL-1β; Ischemia; Motor function