title: [Research hotspot in IgG4-related sialadenitis].
abstract: IgG4-related disease is a novel clinical entity which can affect single or multiple organs. IgG4-related sialadenitis is referred to the salivary gland involvement of IgG4-related disease, with or without other organ involvement. IgG4-related sialadenitis is characterized by painless swelling or enlargement of salivary glands, high serum IgG4 level, abundant IgG4+ plasma cells infiltration with fibrosis histologically, and good response to glucocorticoids. With review of related articles, highlight and provide an overview of the most recent and focused findings and concepts of this disease, including the most significant pathogenic process based on kinds of immunocytes, cytokines, as well as participation of epithelial-mesenchymal transition, the clinical value of elevated serum IgG4 concentration and pathological role of infiltrated IgG4+ plasma cells, the potential relationship with salivary gland malignant tumor, the applying and usefulness of positron emission tomography-CT, the diagnostic utility of lip biopsy, treatment, prognosis, and also future perspectives.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, China.
authors.forename: F Y
authors.initials: FY
authors.lastname: Ping
authors.affiliation: Department of Stomatology, Longsai Hospital, Ningbo Zhejiang 315200, China.
authors.forename: H B
authors.initials: HB
authors.lastname: Pan
mesh_terms: D001706:Biopsy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D010265:Paraproteinemias; D049268:Positron-Emission Tomography; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000097:blood; D012469:Salivary Glands / Q000276:immunology; D012793:Sialadenitis / Q000097:blood* / Q000188:drug therapy / Q000276:immunology
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G