title: GLP-1 Agonists and Blood Pressure: A Review of the Evidence.
abstract: Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease. The presence of concomitant hypertension in diabetics is a major driver of excess cardiovascular risk. Glucagon-like peptide-1 receptor agonists (GLP-1a) act on numerous pathways that intersect glycemic, weight, and blood pressure (BP) control. BP-lowering effects have been observed in mouse models of hypertension with a variety of GLP-1a. Acute administration of GLP-1a in humans has been shown to no effects and sometimes increased BP in humans. Chronic administration of GLP-1a, however, reduces clinic systolic BP (≈2 mmHg) at least when evaluated as a secondary end point in glycemia-lowering studies while simultaneously increasing heart rate. BP lowering has not been consistently observed in two recent double-blind controlled clinical trials evaluating ambulatory BP as the primary end point. While a number of mechanisms including vascular, myocardial, renal, and central nervous system pathways have been suggested in animal studies, these mechanistic pathways have not been sufficiently detailed in humans and it is unclear if the same pathways are operational. Further studies need to be conducted to unravel the full spectrum of effects of this drug class. An understanding of their effects on BP may help provide an explanation for the ability of GLP-1a to influence cardiovascular (CV) events in ongoing event-driven CV trials.
authors.affiliation: Division of Cardiovascular Medicine, University of Maryland Baltimore, 20 Penn St., Health Science Facility II, Baltimore, MD, 21201, USA.|University of Michigan, Ann Arbor, MI, USA.
authors.forename: Aditya
authors.initials: A
authors.lastname: Goud
authors.affiliation: Division of Cardiovascular Medicine, University of Maryland Baltimore, 20 Penn St., Health Science Facility II, Baltimore, MD, 21201, USA.|University of Michigan, Ann Arbor, MI, USA.
authors.forename: Jixin
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Division of Cardiovascular Medicine, University of Maryland Baltimore, 20 Penn St., Health Science Facility II, Baltimore, MD, 21201, USA.|University of Michigan, Ann Arbor, MI, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Peters
authors.affiliation: Division of Cardiovascular Medicine, University of Maryland Baltimore, 20 Penn St., Health Science Facility II, Baltimore, MD, 21201, USA. robdbrok@umich.edu.|University of Michigan, Ann Arbor, MI, USA. robdbrok@umich.edu.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Brook
authors.affiliation: Division of Cardiovascular Medicine, University of Maryland Baltimore, 20 Penn St., Health Science Facility II, Baltimore, MD, 21201, USA. srajagopalan@medicine.umaryland.edu.|University of Michigan, Ann Arbor, MI, USA. srajagopalan@medicine.umaryland.edu.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Rajagopalan
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000188:drug therapy; D052216:Glucagon-Like Peptide 1 / Q000819:agonists*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D012307:Risk Factors
chemical_list: D052216:Glucagon-Like Peptide 1
keywords: Atrial natriuretic peptide; Blood pressure; Cardiovascular disease; Diabetes; Glucagon-like peptide-1 agonist