title: [The Case of a Long-Surviving Patient with Colorectal Neuroendocrine Carcinoma with Invasion of the Jejunum and Lymph Node Metastases after Operation].
abstract: A 44-year-old man presented to our hospital with high fever and right side ache. Laboratory data revealed the presence of inflammation. Enhanced CT of the abdomen revealed a 15 cm mass of the ascending colon, and FDG-PET showed abnormal uptake in the same site. Colonofiberscopy demonstrated an elevated lesion in the ascending colon without malignant findings in biopsies. Enema examination revealed an extrinsic compression of the ascending colon. Although the patient received antibiotic therapy, there were no signs of improvement. Therefore, right hemicolectomy with resection of the invasive lesion of the right abdominal wall and the jejunum was performed. The resected specimen showed a solid tumor, 17×11×8 cm in size, in the ascending colon. The tumor invaded the ileum. Immunohistochemical findings revealed positive staining for NSE, synaptophysin, and chromogranin A. Neuroendocrine carcinoma was thus diagnosed. CPT-11-containing chemotherapy was administered for 1 year after surgery. The patient has been free from recurrent disease for over 7 years after surgery.
authors.affiliation: Dept. of Surgery, Nishijin Hospital.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Noriaki
authors.initials: N
authors.lastname: Koizumi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takagi
authors.forename: Kanehisa
authors.initials: K
authors.lastname: Fukumoto
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy / Q000601:surgery; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007583:Jejunum / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D013997:Time Factors; D016896:Treatment Outcome