title: Hyaluronic Acid-Modified Multifunctional Q-Graphene for Targeted Killing of Drug-Resistant Lung Cancer Cells.
abstract: Considering the urgent need to explore multifunctional drug delivery system for overcoming multidrug resistance, we prepared a new nanocarbon material Q-Graphene as a nanocarrier for killing drug-resistant lung cancer cells. Attributing to the introduction of hyaluronic acid and rhodamine B isothiocyanate (RBITC), the Q-Graphene-based drug delivery system was endowed with dual function of targeted drug delivery and fluorescence imaging. Additionally, doxorubicin (DOX) as a model drug was loaded on the surface of Q-Graphene via π-π stacking. Interestingly, the fluorescence of DOX was quenched by Q-Graphene due to its strong electron-accepting capability, and a significant recovery of fluorescence was observed, while DOX was released from Q-Graphene. Because of the RBITC labeling and the effect of fluorescence quenching/restoring of Q-Graphene, the uptake of nanoparticles and intracellular DOX release can be tracked. Overall, a highly promising multifunctional nanoplatform was developed for tracking and monitoring targeted drug delivery for efficiently killing drug-resistant cancer cells.
authors.affiliation: Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.|Paul G. Allen School for Global Animal Health, Washington State University , PO Box 647090 Pullman, Washington 99164, United States.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Cai
authors.affiliation: School of Mechanical and Materials Engineering, Washington State University , PO Box 642920 Pullman, Washington 99164, United States.
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Mechanical and Materials Engineering, Washington State University , PO Box 642920 Pullman, Washington 99164, United States.|Paul G. Allen School for Global Animal Health, Washington State University , PO Box 647090 Pullman, Washington 99164, United States.
authors.forename: Yuehe
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.|School of Mechanical and Materials Engineering, Washington State University , PO Box 642920 Pullman, Washington 99164, United States.|Paul G. Allen School for Global Animal Health, Washington State University , PO Box 647090 Pullman, Washington 99164, United States.
authors.forename: Dan
authors.initials: D
authors.lastname: Du
mesh_terms: D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000494:pharmacology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D004337:Drug Carriers; D006108:Graphite; D004317:Doxorubicin; D006820:Hyaluronic Acid
keywords: MDR; Q-Graphene; drug delivery; imaging; tumor cell targeting