title: Tuning Reaction and Diffusion Mediated Degradation of Enzyme-Sensitive Hydrogels.
abstract: Enzyme-sensitive hydrogels are promising for cell encapsulation and tissue engineering, but result in complex spatiotemporal degradation behavior that is characteristic of reaction-diffusion mechanisms. An experimental and theoretical approach is presented to identify dimensionless quantities that serve as a design tool for engineering enzyme-sensitive hydrogels with controlled degradation patterns by tuning the initial hydrogel properties and enzyme kinetics.
authors.affiliation: Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, 80309, USA.
authors.forename: Stacey C
authors.initials: SC
authors.lastname: Skaalure
authors.affiliation: Department of Mechanical Engineering, University of Colorado, Boulder, CO, 80309, USA.
authors.forename: Umut
authors.initials: U
authors.lastname: Akalp
authors.affiliation: Department of Mechanical Engineering, Material Science and Engineering Program, University of Colorado, Boulder, CO, 80309, USA.
authors.forename: Franck J
authors.initials: FJ
authors.lastname: Vernerey
authors.affiliation: Department of Chemical and Biological Engineering, Material Science and Engineering Program, BioFrontiers Institute, University of Colorado, Boulder, CO, 80303, USA.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Bryant
mesh_terms: D003198:Computer Simulation; D004058:Diffusion; D004798:Enzymes / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008962:Models, Theoretical; D011092:Polyethylene Glycols / Q000737:chemistry; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D004798:Enzymes; D020100:Hydrogels; D011092:Polyethylene Glycols
keywords: computational models; enzyme degradation; hydrogel; reaction-diffusion; tissue engineering