title: Human Leukocyte Antigen-G Polymorphisms Association With Cancer Post-Heart Transplantation.
abstract: BACKGROUND
  Post transplantation, a major complication is the development of malignancies. Human Leukocyte Antigen (HLA)-G is a molecule that inhibits the immune system and it is utilized by malignant cells to hide from the immune system. Expression of HLA-G from the donor and recipient cells in transplant patients is regulated by gene variations however, the association between genotype and cancer remains unknown. Our objective was to determine the association between genotype and outcome.
  
  
  METHODS
  Heart transplant recipients (251) and available corresponding donors (196) samples were genotyped for polymorphisms and the association of polymorphisms to outcome was evaluated with parametric hazard regression models.
  
  
  RESULTS
  Risk of cancer was 22% at 10years post-transplantation. The mean follow-up was of 4.9±3.6years. In a multivariable analysis, donor-recipient SNP 3187 matching was identified as a protective factor for cancer (hazard ratio 0.43; 95% confidence interval 0.19-0.93; p=0.03). While coding region allele (haplotype 6) was identified as an independent risk factor (hazard ratio 3.7; 95% confidence interval 1.36-10.06; p=0.01).
  
  
  CONCLUSIONS
  In this investigation, we identified an association between cancer post-transplantation and HLA-G polymorphisms, which may reveal a pathway for potential diagnostic and therapeutic strategies for cancer post-transplantation.
authors.affiliation: Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital-University Health Network, Toronto, Ontario, Canada. Electronic address: julieta.lazarte@mail.utoronto.ca.
authors.forename: Julieta
authors.initials: J
authors.lastname: Lazarte
authors.affiliation: Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital-University Health Network, Toronto, Ontario, Canada.
authors.forename: Livia
authors.initials: L
authors.lastname: Goldraich
authors.affiliation: Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital-University Health Network, Toronto, Ontario, Canada.
authors.forename: Cedric
authors.initials: C
authors.lastname: Manlhiot
authors.affiliation: Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital-University Health Network, Toronto, Ontario, Canada.
authors.forename: Stella
authors.initials: S
authors.lastname: Kozuszko
authors.affiliation: Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital-University Health Network, Toronto, Ontario, Canada.
authors.forename: Vivek
authors.initials: V
authors.lastname: Rao
authors.affiliation: Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital-University Health Network, Toronto, Ontario, Canada.
authors.forename: Diego
authors.initials: D
authors.lastname: Delgado
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D059951:HLA-G Antigens / Q000235:genetics*; D016027:Heart Transplantation; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000235:genetics*; D012306:Risk; D014019:Tissue Donors; D055815:Young Adult
chemical_list: D059951:HLA-G Antigens
keywords: Cancer; HLA-G; HLA-G polymorphisms; Post-heart transplantation