title: Evaluation of a 1540-nm and a 1410-nm Nonablative Fractionated Laser for the Treatment of Striae.
abstract: BACKGROUND
  Aesthetically, striae distensae (SD) are a source of great concern. No treatment modality is currently considered the gold standard. However, studies of nonablative fractionated lasers (NAFLs) have been promising.
  
  
  OBJECTIVE
  To evaluate and compare the clinical and histopathologic efficacy and safety of a 1540-nm NAFL and a 1410-nm NAFL for the treatment of SD.
  
  
  METHODS
  Nine patients with abdominal striae were treated for 6 sessions-half of the abdomen was treated with a 1540-nm NAFL whereas the other half was treated with a 1410-nm NAFL. Photographs were taken at baseline and at the 3-month follow-up visit, when subjects were given a questionnaire. Two blinded dermatologists scored the photographs using a pre-established clinical scale. Biopsies were taken from 2 subjects and graded by 2 dermatopathologists using a pre-established pathology scale.
  
  
  RESULTS
  All 9 subjects demonstrated clinical improvement bilaterally after treatment. Skin biopsies after treatment showed an increase in epidermal thickness, dermal thickness, and collagen and elastin density when compared with baseline. Clinical and histopathological differences between the 2 lasers were not statistically significant.
  
  
  CONCLUSIONS
  Treatment with both the 1540-nm and the 1410-nm NAFL was shown to improve SD clinically and histopathologically. Further studies are needed to optimize treatment parameters.
authors.affiliation: Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Krystle
authors.initials: K
authors.lastname: Wang
authors.forename: Nicholas
authors.initials: N
authors.lastname: Ross
authors.forename: Katie
authors.initials: K
authors.lastname: Osley
authors.forename: Joya
authors.initials: J
authors.lastname: Sahu
authors.forename: Nazanin
authors.initials: N
authors.lastname: Saedi
mesh_terms: D000005:Abdomen / Q000473:pathology; D000293:Adolescent; D000328:Adult; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D057896:Striae Distensae / Q000473:pathology / Q000628:therapy*; D055815:Young Adult