title: Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells.
abstract: A 1,2-dioxolane (FINO2) was identified as a lead compound from a screen of organic peroxides. FINO2 does not induce apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative cell death pathway. Few compounds are known to induce primarily ferroptosis. In contrast to the perceived instability of peroxides, FINO2 was found to be thermally stable to at least 150 °C. FINO2 was more potent in cancer cells than nonmalignant cells of the same type. One of the enantiomers was found to be more responsible for the observed activity.
authors.affiliation: Department of Chemistry, New York University , 100 Washington Square East, New York, New York 10003, United States.|Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center , 522 First Avenue, New York, New York 10016, United States.
authors.forename: Rachel P
authors.initials: RP
authors.lastname: Abrams
authors.affiliation: Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center , 522 First Avenue, New York, New York 10016, United States.
authors.forename: William L
authors.initials: WL
authors.lastname: Carroll
authors.affiliation: Department of Chemistry, New York University , 100 Washington Square East, New York, New York 10003, United States.
authors.forename: K A
authors.initials: KA
authors.lastname: Woerpel
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects*; D002460:Cell Line; D045744:Cell Line, Tumor; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010545:Peroxides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010545:Peroxides