title: Chemotherapy for urothelial carcinoma in renal transplantation patients: Initial results from a single center.
abstract: The aim of this study was to assess the safety and efficacy of gemcitabine plus cisplatin/carboplatin (GC/GCa) chemotherapy in renal transplantation (RT) patients with urothelial carcinoma (UC). We reviewed the records of 12 RT patients with metastatic or locally advanced UC who received chemotherapy at our institution since January, 2013. All the patients received intravenous gemcitabine (800 mg/m2) on days 1, 8 and 15, plus cisplatin (70 mg/m2) or carboplatin (area under the curve = 5) on day 2, every 28 days. A total of 10 patients completed all the cycles, while 1 patient discontinued treatment due to disease progression and 1 patient discontinued due to non-medical reasons. In total, 12 patients received a median of four cycles of chemotherapy. The overall response rate was 50% (4/8 cases) in patients with measurable lesions. At the time of the study, 5 patients had succumbed to the disease (overall survival, 9.2 months), while 7 patients remained alive (follow-up time, 13.3 months). The most common toxicities were myelosuppression and gastrointestinal effects. Therefore, the GC/GCa regimen was found to be effective and tolerable in RT patients with UC. However, further studies involving more patients and control groups are required to confirm our results.
authors.affiliation: Department of Urology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Yichen
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Urology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Urology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Urology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Urology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Urology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Y E
authors.initials: YE
authors.lastname: Tian
keywords: chemotherapy; renal transplantation; urothelial carcinoma