title: Cytotoxic trichothecene macrolides from the endophyte fungus Myrothecium roridum.
abstract: A new cytotoxic roridin-type trichothecene macrolide named epiroridin acid (1) and two known compounds epiroridin E (2) and mytoxin B (3) were isolated from the liquid culture of Myrothecium roridum A553, which was isolated from the medicinal plant Pogostemon cablin. The structure of the new macrolide (1) was elucidated by extensive spectroscopic measurements (UV, IR, MS, and 1D and 2D NMR) analyses. All isolated compounds (1-3) were evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. The new compound (1) exhibited well cytotoxicity against the four selected tumor cell lines.
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Hong-Xin
authors.initials: HX
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.|b College of Pharmacy, Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Wei-Zhen
authors.initials: WZ
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Yu-Chan
authors.initials: YC
authors.lastname: Chen
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Zhang-Hua
authors.initials: ZH
authors.lastname: Sun
authors.affiliation: b College of Pharmacy, Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Yu-Zhi
authors.initials: YZ
authors.lastname: Tan
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Hao-Hua
authors.initials: HH
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D060026:Endophytes; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D014255:Trichothecenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D018942:Macrolides; D014255:Trichothecenes; C000613436:epiroridin acid
keywords: Myrothecium roridum; cytotoxic activity; endophytic fungus; trichothecene macrolide