title: Extranodal Rosai-Dorfman Disease: Clinicopathologic Series of 10 Patients With Radiologic Correlation and Review of the Literature.
abstract: OBJECTIVE
  To describe the radiologic and clinicopathologic features of extranodal Rosai-Dorfman disease (RDD) in our patient population.
  
  
  METHODS
  Via a data mining engine, we evaluated 13 cases of extranodal RDD in 10 patients treated at our institution from 2000 to 2014.
  
  
  RESULTS
  There was a marked female predominance (90%) in our series. The most common clinical presentation was a palpable, painless mass, which often simulated a neoplasm. Only two cases occurred in children. Multicentric and recurrent disease were uncommon. Histologically, all cases showed large histiocytes with emperipolesis in a mixed inflammatory background, with areas of dense, storiform collagen fibrosis. Positive S-100 and CD68 with negative CD1a in histiocytes are characteristic.
  
  
  CONCLUSIONS
  Extranodal RDD is rare and its manifestations varied. It may constitute a clinical and pathologic diagnostic challenge. Clinical suspicion and recognition of its histologic features are necessary for correct diagnosis and avoiding unnecessary treatment. Resection is curative in most cases.
authors.affiliation: From the Departments of Pathology and ywang@montefiore.org.
authors.forename: Jose G
authors.initials: JG
authors.lastname: Mantilla
authors.affiliation: Radiology, Albert Einstein College of Medicine-Montefiore Medical Center, Bronx, NY.
authors.forename: Shlomit
authors.initials: S
authors.lastname: Goldberg-Stein
authors.affiliation: From the Departments of Pathology and.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D057687:Emperipolesis; D005260:Female; D005355:Fibrosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D006644:Histiocytes / Q000473:pathology*; D015618:Histiocytosis, Sinus / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000378:metabolism*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule
keywords: Bone; Breast; Gastrointestinal; Hematopathology; Soft tissue