title: [Identifying clinical risk factors in recurrent idiopathic deep venous thrombosis].
abstract: OBJECTIVE
  Oral anticoagulant therapy for more than 6 months in patients with an episode of idiopathic thromboembolic disease is controversial. The objective was to determine predictive clinical signs that identify patients at increased risk of thromboembolic recurrence after stopping anticoagulant therapy for 6 months after an episode of idiopathic deep vein thrombosis (DVT).
  
  
  METHODS
  A prospective study which included 306 consecutive patients with a first episode of idiopathic DVT from June 2012 to June 2014. Predictor variables of recurrent thromboembolic disease and episodes of recurrence during follow-up of the patients (28.42 months) were collected. We performed a multivariate analysis to analyze possible predictors (P<.20) and an analysis of Kaplan-Meier to establish mean recurrence-free survival.
  
  
  RESULTS
  We identified 91 episodes of residual vein thrombosis on follow-up of the patients (37.5% men and 20.3% women) (OR 1.84; 95% CI 1.25-2.71). In the Cox regression analysis stratified by gender, variables showed significant presence of hyperechoic thrombus (P=.001) in males, and persistence of residual thrombus in women (P=.046). The mean recurrence-free survival was shorter in both groups.
  
  
  CONCLUSIONS
  The presence of echogenic thrombus in men and the existence of residual DVT in women were 2 clinical signs associated with increased risk of thromboembolic recurrence after stopping anticoagulant therapy for 6 months after an episode of idiopathic DVT in our study.
authors.affiliation: Servicio de Angiología y Cirugía Vascular, Hospital Clínico Universitario de Valladolid, Valladolid, España. Electronic address: mlriosol@yahoo.es.
authors.forename: M Lourdes
authors.initials: ML
authors.lastname: Del Río Solá
authors.affiliation: Servicio de Angiología y Cirugía Vascular, Hospital Clínico Universitario de Valladolid, Valladolid, España.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: González Fajardo
authors.affiliation: Servicio de Angiología y Cirugía Vascular, Hospital Clínico Universitario de Valladolid, Valladolid, España.
authors.forename: Carlos
authors.initials: C
authors.lastname: Vaquero Puerta
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D012008:Recurrence; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control
chemical_list: D000925:Anticoagulants
keywords: Enfermedad tromboembólica; Factores de riesgo; Idiopathic deep venous thrombosis; Risk factors; Thromboembolism; Trombosis venosa profunda idiopática