title: Release of Enterococcus mundtii Bacteriocin ST4SA from Self-Setting Brushite Bone Cement.
abstract: Maxillofacial and craniofacial surgery is on the increase, which exposes more patients at risk of acquiring microbial infections. The use of antibiotic-loaded calcium phosphate bone cements has been shown to reduce the incidence of infection. A marked increase in antibiotic-resistant pathogens, including multidrug-resistant pathogens, has been reported. This has led to the investigation of various compounds as alternatives to conventional treatments. In this paper, we report on the incorporation and release of a broad-spectrum class II antimicrobial peptide, bacteriocin ST4SA produced by Enterococcus mundtii, into a calcium orthophosphate-based bone cement. Our results suggest class II bacteriocins may be incorporated into self-setting bone cements to produce implants with antimicrobial activity over extended periods of time.
authors.affiliation: Department of Microbiology, University of Stellenbosch, Stellenbosch, 7600, South Africa.
authors.forename: Anton D
authors.initials: AD
authors.lastname: van Staden
authors.affiliation: Department of Microbiology, University of Stellenbosch, Stellenbosch, 7600, South Africa.
authors.forename: Tiaan D J
authors.initials: TD
authors.lastname: Heunis
authors.affiliation: Department of Microbiology, University of Stellenbosch, Stellenbosch, 7600, South Africa. lmtd@sun.ac.za.|, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa. lmtd@sun.ac.za.
authors.forename: Leon M T
authors.initials: LM
authors.lastname: Dicks
keywords: Antimicrobial activity; Bacteriocin; Brushite bone cement