title: Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance.
abstract: Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid inEscherichia colidepend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.
authors.affiliation: Department of Biology, University of York, York, United Kingdom mjmb500@york.ac.uk.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bottery
authors.affiliation: Department of Biology, University of York, York, United Kingdom Department of Mathematics, University of York, York, United Kingdom.
authors.forename: A Jamie
authors.initials: AJ
authors.lastname: Wood
authors.affiliation: Department of Biology, University of York, York, United Kingdom.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Brockhurst
mesh_terms: D000222:Adaptation, Physiological; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics*; D015870:Gene Expression; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000737:chemistry* / Q000378:metabolism; D012641:Selection, Genetic; D013752:Tetracycline / Q000494:pharmacology; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin; D001618:beta-Lactamases; D013752:Tetracycline