title: Solubilization and Interaction Studies of Bile Salts with Surfactants and Drugs: a Review.
abstract: In this review, bile salt, bile salt-surfactant, and bile salt-drug interactions and their solubilization studies are mainly focused. Usefulness of bile salts in digestion, absorption, and excretion of various compounds and their rare properties in ordering the shape and size of the micelles owing to the presence of hydrophobic and hydrophilic faces are taken into consideration while compiling this review. Bile salts as potential bio-surfactants to solubilize drugs of interest are also highlighted. This review will give an insight into the selection of drugs in different applications as their properties get modified by interaction with bile salts, thus influencing their solution behavior which, in turn, modifies the phase-forming behavior, microemulsion, and clouding phenomenon, besides solubilization. Finally, their future perspectives are taken into consideration to assess their possible uses as bio-surfactants without side effects to human beings.
authors.affiliation: Department of Chemistry, University of Kashmir, Hazratbal, Srinagar, 190006, India. nisarchmjmi@gmail.com.
authors.forename: Nisar Ahmad
authors.initials: NA
authors.lastname: Malik
mesh_terms: D001647:Bile Acids and Salts / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D001647:Bile Acids and Salts; D004364:Pharmaceutical Preparations; D010713:Phosphatidylcholines; D013501:Surface-Active Agents
keywords: Bile salts; Drugs; Interactions; Physico-chemical properties; Surfactants; Thermodynamics