title: Understanding auditory neuropathy spectrum disorder: a systematic review in transgenic mouse models.
abstract: Auditory neuropathy spectrum disorder is a unique group of hearing dysfunctions characterized by preserved outer hair cell function and abnormal neural conduction of the auditory pathway. However, the pathogenic mechanism underlying this disorder is not clear. We therefore performed a systematic review of genetic mouse models with different gene mutations to provide a valuable tool for better understanding of the process and the possible molecular mechanisms. Of the 18 articles retrieved, nine met the required criteria. All biochemical, histological, and electrophysiological results were recorded for each of the mouse models, as was the transgenic technology. This review provides a summary of different mouse models that may play an important role in the diagnosis and management of auditory neuropathy spectrum disorder in the future.
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.|Medical College, Nankai University, Tianjin, 300071, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Guan
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.
authors.forename: Hongyang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Lan
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.
authors.forename: Qiujing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zong
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Du
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.
authors.forename: Wenping
authors.initials: W
authors.lastname: Xiong
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.
authors.forename: Fengjiao
authors.initials: F
authors.lastname: Li
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.
authors.forename: Kaiwen
authors.initials: K
authors.lastname: Wu
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China.
authors.forename: Dayong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China. wqcr301@sina.com.
authors.forename: Qiuju
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006313:Hearing Loss, Central / Q000503:physiopathology*; D051379:Mice; D008822:Mice, Transgenic
keywords: auditory neuropathy spectrum disorder; pathogenesis; systematic review; transgenic mouse models