title: Should I stop or should I go? The role of complexin in neurotransmitter release.
abstract: When it comes to fusion with the neuronal cell membrane, does a synaptic vesicle have a choice whether to stop or to go? Recent work suggests that complexin, a tiny protein found within the synaptic terminal, contributes to the mechanism through which this choice is made. How complexin plays this consulting part and which synaptic vesicle proteins it interacts with remain open questions. Indeed, studies in mice and flies have led to the proposal of different models of complexin function. We suggest that understanding the modular nature of complexin will help us to unpick its role in synaptic vesicle release.
authors.affiliation: Neuroscience Research Center, Charité Universitätsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Trimbuch
authors.affiliation: Neuroscience Research Center, Charité Universitätsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Rosenmund
mesh_terms: D000818:Animals; D001692:Biological Transport; D002459:Cell Fusion; D005089:Exocytosis; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents