title: One-dimensional collective migration of a proliferating cell monolayer.
abstract: The importance of collective cellular migration during embryogenesis and tissue repair asks for a sound understanding of underlying principles and mechanisms. Here, we address recent in vitro experiments on cell monolayers, which show that the advancement of the leading edge relies on cell proliferation and protrusive activity at the tissue margin. Within a simple viscoelastic mechanical model amenable to detailed analysis, we identify a key parameter responsible for tissue expansion, and we determine the dependence of the monolayer velocity as a function of measurable rheological parameters. Our results allow us to discuss the effects of pharmacological perturbations on the observed tissue dynamics.
authors.affiliation: Mathematical Institute, University of Oxford, Oxford OX26GG, UK and Sorbonne Université, UPMC Univ Paris 06, Institut Curie, CNRS, UMR 168, Laboratoire Physco-Chimie Curie, Paris, France. philippe.marcq@curie.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Recho
authors.affiliation: Laboratoire de Physique Statistique, École Normale Supérieure, 24 rue Lhomond, F-75231 Paris Cedex 05, France.
authors.forename: Jonas
authors.initials: J
authors.lastname: Ranft
authors.affiliation: Sorbonne Université, UPMC Univ Paris 06, Institut Curie, CNRS, UMR 168, Laboratoire Physco-Chimie Curie, Paris, France. philippe.marcq@curie.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Marcq
mesh_terms: D002465:Cell Movement; D049109:Cell Proliferation; D002477:Cells / Q000737:chemistry / Q000166:cytology*; D008954:Models, Biological