title: Amorphous powders for inhalation drug delivery.
abstract: For inhalation drug delivery, amorphous powder formulations offer the benefits of increased bioavailability for poorly soluble drugs, improved biochemical stability for biologics, and expanded options of using various drugs and their combinations. However, amorphous formulations usually have poor physicochemical stability. This review focuses on inhalable amorphous powders, including the production methods, the active pharmaceutical ingredients and the excipients with a highlight on stabilization of the particles.
authors.affiliation: School of Medical Instrument and Food Engineering; University of Shanghai for Science and Technology; Shanghai 200093; China.
authors.forename: Lan
authors.initials: L
authors.lastname: Chen
authors.affiliation: Faculty of Pharmacy; Meijo University; 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503; Japan; Advanced Drug Delivery Group; Faculty of Pharmacy; The University of Sydney; Sydney; 2006, NSW, Australia.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Okuda
authors.affiliation: School of Medical Instrument and Food Engineering; University of Shanghai for Science and Technology; Shanghai 200093; China.
authors.forename: Xiang-Yun
authors.initials: XY
authors.lastname: Lu
authors.affiliation: Advanced Drug Delivery Group; Faculty of Pharmacy; The University of Sydney; Sydney; 2006, NSW, Australia.
authors.forename: Hak-Kim
authors.initials: HK
authors.lastname: Chan
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D005079:Excipients; D006801:Humans; D010316:Particle Size; D011208:Powders
chemical_list: D000336:Aerosols; D005079:Excipients; D011208:Powders
keywords: Aerodynamic diameter; Amorphous; Dry powder inhaler; Excipient; Solubility; Spray drying; Stability