title: The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.
abstract: The apolipoprotein E ε4 allele (APOE4) is an established risk factor for dementia; however, conflicting findings have been reported as to whether this phenotype confers a heightened risk for late onset depression (LOD) independent of dementia. We examined 2242 persons for incident LOD who also underwent genotyping for APOE4. Major LOD was associated with female sex (odds ratio, 3.61; 95% confidence interval, 1.89-6.90). APOE4 was not associated with major LOD regardless of whether dementia was excluded. In conclusion, we showed that the APOE4 phenotype holds no predictive value for major LOD.
authors.affiliation: University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; INSERM, Neuroepidemiology, UMR897, Bordeaux, France. Electronic address: phillip.tully@adelaide.edu.au.
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Tully
authors.affiliation: University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Péres
authors.affiliation: INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Université Montpellier 1, Hôpital La Colombière, Montpellier, France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Berr
authors.affiliation: University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics*; D003704:Dementia / Q000235:genetics; D003863:Depression / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D012307:Risk Factors; D012727:Sex Characteristics
chemical_list: D053327:Apolipoprotein E4
keywords: Ageing; Apolipoprotein E4; Dementia; Late onset depression; Major depression