title: Oral Squamomelanocytic Tumour in a Dog: a Unique Biphasic Cancer.
abstract: In human medicine, squamomelanocytic tumour is a malignant cutaneous neoplasm composed of closely intermingled neoplastic squamous cells and melanocytes. A multinodular gingival tumour in a 16-year-old, mixed breed neutered female dog was examined microscopically. Two populations of neoplastic cells, melanocytic and squamous epithelial cells were intermingled. The melanocytic cells were melan-A positive and cytokeratin AE1-AE3 negative and the squamous component was cytokeratin AE1-AE3 positive and melan-A negative. Bovine papillomavirus was not identified by immunohistochemistry or polymerase chain reaction. A diagnosis of squamomelanocytic tumour was made.
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy. Electronic address: luisaver.muscatello2@unibo.it.
authors.forename: L V
authors.initials: LV
authors.lastname: Muscatello
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Avallone
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Benazzi
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Sarli
authors.affiliation: Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Porcellato
authors.affiliation: Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Brachelente
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Brunetti
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D008545:Melanoma / Q000473:pathology / Q000662:veterinary*; D009062:Mouth Neoplasms / Q000473:pathology / Q000662:veterinary*
keywords: dog; melanoma; oral cavity; squamous cell carcinoma