title: The effect of 1 year of trilostane treatment on peripheral lymphocyte subsets in dogs with pituitary-dependent hyperadrenocorticism.
abstract: This study investigated the changes in lymphocyte subsets during the trilostane medication of Pituitary-dependent hyperadrenocorticism (PDH) dogs. The cortisol level and lymphocyte subsets of eight dogs with PDH were monitored 0, 1, 3, 6, 9 and 12 months after the initiation of trilostane treatment. White blood cells (WBC), lymphocytes, CD3(+) (T lymphocyte), CD4(+) (helper T lymphocyte), CD8(+) (cytotoxic T lymphocyte) and CD21(+) (B lymphocyte) cells were measured. Although the post-ACTH stimulation test cortisol level was significantly lower during trilostane treatment, changes in the CD3(+), CD4(+), CD8(+) and CD21(+) counts were not observed. Meanwhile, significant decrease was observed in WBC counts during trilostane treatment. These indicate that long-term trilostane treatment has little effect on the lymphocyte subsets in PDH dogs.
authors.affiliation: School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Oda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Mori
authors.forename: Saori
authors.initials: S
authors.lastname: Shono
authors.forename: Eri
authors.initials: E
authors.lastname: Onozawa
authors.forename: Toshinori
authors.initials: T
authors.lastname: Sako
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D018791:CD4 Lymphocyte Count / Q000662:veterinary; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D013196:Dihydrotestosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000276:immunology; D004285:Dogs; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D016131:Lymphocyte Subsets / Q000187:drug effects*; D008297:Male; D065088:Steroid Synthesis Inhibitors / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D065088:Steroid Synthesis Inhibitors; D013196:Dihydrotestosterone; D000324:Adrenocorticotropic Hormone; C009954:trilostane; D006854:Hydrocortisone