title: Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function.
abstract: Central fat accumulation is a strong risk factor for type 2 diabetes. Genome-wide association studies have identified numerous loci associated with body fat distribution. The objectives of the current study are to examine whether genes in genetic loci linked to fat distribution can be linked to fat cell size and number (morphology) and/or adipose tissue function. We show, in a cohort of 114 women, that almost half of the 96 genes in these loci are indeed associated with abdominal subcutaneous adipose tissue parameters. Thus, adipose mRNA expression of the genes is strongly related to adipose morphology, catecholamine-induced lipid mobilization (lipolysis), or insulin-stimulated lipid synthesis in adipocytes (lipogenesis). In conclusion, the genetic influence on body fat distribution could be mediated via several specific alterations in adipose tissue morphology and function, which in turn may influence the development of type 2 diabetes.
authors.affiliation: Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden peter.arner@ki.se ingrid.dahlman@ki.se.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Dahlman
authors.affiliation: Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Mikael
authors.initials: M
authors.lastname: Rydén
authors.affiliation: Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
authors.forename: David
authors.initials: D
authors.lastname: Brodin
authors.affiliation: German Center for Diabetes Research (DZD), Neuherberg, Germany Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Grallert
authors.affiliation: Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Rona J
authors.initials: RJ
authors.lastname: Strawbridge
authors.affiliation: Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden peter.arner@ki.se ingrid.dahlman@ki.se.
authors.forename: Peter
authors.initials: P
authors.lastname: Arner
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000502:physiology*; D000273:Adipose Tissue / Q000502:physiology*; D050154:Adiposity / Q000235:genetics*; D000328:Adult; D000368:Aged; D002452:Cell Count; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050155:Lipogenesis / Q000502:physiology; D008066:Lipolysis / Q000235:genetics; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D050507:Subcutaneous Fat, Abdominal / Q000502:physiology; D013548:Sweden; D055815:Young Adult
chemical_list: D007328:Insulin; D012333:RNA, Messenger