title: 2D:4D finger ratio positively correlates with total cerebral cortex in males.
abstract: Although there is evidence that the ratio of 2nd-4th digit length (2D:4D) correlates with prenatal testosterone level, psychological and health traits only two studies have assessed the relationship with brain morphological features. Here we investigated the association between the 2D:4D ratio and several brain subvolumes. Seventy-five subjects between the ages of 18 and 30 were included in the study. The length of the 2nd and 4th digits were measured with an electronic vernier caliper while MRI measurements were performed on a Siemens Magnetom Trio Tim (3T) system. Freesurfer software suite was used for volumetric segmentation. Finger ratio significantly positively correlated with total cerebral cortex, total cerebellar white matter and total cerebellar cortex in males but not in females. Our results indicate that prenatal testosterone, as estimated by the 2D:4D ratio has an effect on adult brain morphology in males.
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary. Electronic address: darnai.gergely@pte.hu.
authors.forename: Gergely
authors.initials: G
authors.lastname: Darnai
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary.
authors.forename: Enikő
authors.initials: E
authors.lastname: Plózer
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary; Pécs Diagnostic Centre, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Perlaki
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary; Pécs Diagnostic Centre, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary.
authors.forename: Gergely
authors.initials: G
authors.lastname: Orsi
authors.affiliation: Pécs Diagnostic Centre, Pécs, Hungary.
authors.forename: Szilvia Anett
authors.initials: SA
authors.lastname: Nagy
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary.
authors.forename: Réka
authors.initials: R
authors.lastname: Horváth
authors.affiliation: MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary; Department of Neurosurgery, Pécs, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Schwarcz
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary.
authors.forename: Norbert
authors.initials: N
authors.lastname: Kovács
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary; Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Anna
authors.initials: A
authors.lastname: Altbäcker
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Janszky
authors.affiliation: Department of Neurology, University of Pécs, Pécs, Hungary; National Institute of Clinical Neuroscience, Budapest, Hungary.
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Clemens
mesh_terms: D000293:Adolescent; D000328:Adult; D002525:Cerebellar Cortex / Q000033:anatomy & histology; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D002552:Cerebral Ventricles / Q000033:anatomy & histology; D005385:Fingers / Q000033:anatomy & histology*; D006801:Humans; D008297:Male; D009929:Organ Size; D066127:White Matter / Q000033:anatomy & histology; D055815:Young Adult
keywords: 2D:4D; Brain volumetry; Finger ratio; Total cerebellar cortex; Total cerebellar white matter; Total cerebral cortex