title: Higher pre-pregnancy body mass index is associated with excessive gestational weight gain in normal weight Chinese mothers with gestational diabetes.
abstract: OBJECTIVE
  To assess how pre-pregnancy body mass index (BMI) affects pregnancy outcome and total gestational weight gain (GWG) in a cohort of women with gestational diabetes (GDM).
  
  
  METHODS
  Pregnant women at 24-28 gestational weeks diagnosed with GDM were classified as normal weight (pre-pregnancy BMI, 18.5-24.9 kg/m(2) ) or overweight (pre-pregnancy BMI, 25.0-29.9 kg/m(2) ). GWG was derived from the self-reported pre-pregnancy and pre-delivery weights, and analyzed using 2009 Institute of Medicine categories.
  
  
  RESULTS
  A total of 106 GDM women were categorized as normal weight (n = 79) or overweight (n = 27). No statistically significant differences were found between the groups in terms of various obstetrical and neonatal outcomes. Higher pre-pregnancy BMI, however, was associated with excessive GWG during pregnancy (difference between groups, P = 0.013). Furthermore, pre-pregnancy BMI (OR, 0.529; 95%CI: 0.377-0.742; P = 0.000) and pre-pregnancy overweight (OR, 3.825; 95%CI: 1.469-9.959; P = 0.006) were independent factors of GWG.
  
  
  CONCLUSIONS
  Among Chinese GDM women, overweight GDM mothers gain excessive weight during pregnancy. Regulation of pre-pregnancy bodyweight might be an appropriate precaution against excessive GWG.
authors.affiliation: Departments of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Departments of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Obstetrics and Gynecology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.affiliation: Departments of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
authors.forename: Pin
authors.initials: P
authors.lastname: Wang
authors.affiliation: Departments of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Xia
authors.affiliation: Departments of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.affiliation: Departments of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Cai
authors.affiliation: Departments of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Sun
authors.affiliation: Departments of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000453:epidemiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D050177:Overweight / Q000150:complications / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011446:Prospective Studies; D015430:Weight Gain
keywords: gestational diabetes mellitus; pre-pregnancy body mass index; pregnancy outcome; pregnancy weight gain