title: Factors affecting platinum sensitivity in cervical cancer.
abstract: The present study aimed to investigate the association between nedaplatin (NDP) sensitivity and the expression of biological factors in cervical cancer. A total of 45 cervical cancer specimens, including 18 pretreatment biopsies and 27 surgical specimens, were used in histoculture drug response assays to determine the chemosensitivity of cervical cancer specimens to NDP. Each specimen was assessed for immunohistochemical expression of Ki-67, p53, B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), cleaved caspase-3, cyclooxygenase-2 (COX-2), and excision repair cross-complementation group 1 (ERCC1). The results revealed that low or negative expression of p53, Bcl-2 and COX-2, and high or positive expression of cleaved caspase-3 were significantly correlated with high sensitivity to NDP. However, there were no significant differences in Ki-67, Bax or ERCC1 expression between the low and high sensitivity groups. These findings indicate that sensitivity to platinum may be easily predicted by immunostaining for the detection of these specific factors in pretreatment biopsies or surgical specimens. The expression profiles of these targets may therefore provide additional information for planning individualized chemotherapy in the treatment of cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo 160-0023, Japan; Department of Obstetrics and Gynecology, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
authors.forename: Rina
authors.initials: R
authors.lastname: Kato
authors.affiliation: Department of Obstetrics and Gynecology, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hasegawa
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Torii
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan; Department of Obstetrics and Gynecology, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Udagawa
authors.affiliation: Department of Obstetrics and Gynecology, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
authors.forename: Ichio
authors.initials: I
authors.lastname: Fukasawa
keywords: biological factors; cervical cancer; chemosensitivity; nedaplatin; platinum