title: Black titania-based theranostic nanoplatform for single NIR laser induced dual-modal imaging-guided PTT/PDT.
abstract: Substantially different from traditional combinatorial-treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) by using multi-component nanocomposite under excitation of separate wavelength, a novel single near infrared (NIR) laser-induced multifunctional theranostic nanoplatform has been rationally and successfully constructed by a single component black titania (B-TiO2-x) for effective imaging-guided cancer therapy for the first time. This multifunctional PEGylated B-TiO2-x shows high dispersity/stability in aqueous solution, excellent hemo/histocompatibility and broad absorption ranging from NIR to ultraviolet (UV). Both in vitro and in vivo results well demonstrated that such a novel multifunctional theranostic nanoplaform could achieve high therapeutic efficacy of simultaneous and synergistic PTT/PDT under the guidance of infrared thermal/photoacoustic (PA) dual-modal imaging, which was triggered by a single NIR laser. This research circumvents the conventional obstacles of using multi-component nanocomposites, UV light and high laser power density. Furthermore, negligible side effects to blood and main tissues could be found in 3 months' investigation, facilitating its potential biomedical application.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Mou
authors.affiliation: CAS Key Laboratory of Materials for Energy Conversion, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Tianquan
authors.initials: T
authors.lastname: Lin
authors.affiliation: CAS Key Laboratory of Materials for Energy Conversion, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Huang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: hrchen@mail.sic.ac.cn.
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: jlshi@mail.sic.ac.cn.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D008819:Mice, Nude; D064847:Multimodal Imaging; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D016716:PC12 Cells; D010778:Photochemotherapy; D051381:Rats; D019265:Spectroscopy, Near-Infrared; D013194:Staining and Labeling; D000068936:Theranostic Nanomedicine; D014025:Titanium / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: C009495:titanium dioxide; D014025:Titanium
keywords: Black titania; Photoacoustic imaging; Photodynamic therapy; Photothermal therapy; Single NIR laser