title: Examining the Role of Anxiety Sensitivity in Sleep Dysfunction Across Anxiety Disorders.
abstract: Anxiety Sensitivity (AS) has been associated with sleep difficulties in certain anxiety disorder populations, but no studies have examined cross-diagnostically the role of anxiety sensitivity in sleep dysfunction. Three hundred one participants with generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder (PD) completed an ancillary questionnaire-based study. Linear regression was used to examine AS and sleep dysfunction, and mediation analyses were used to examine whether AS was a mediator of the effect of primary diagnosis on sleep. AS was associated with increased sleep dysfunction across anxiety disorders, and primary anxiety disorder diagnosis was significantly associated with sleep dysfunction. However, after controlling for AS, primary diagnosis was no longer significant. AS significantly mediated the effects of PD versus SAD and of PD versus GAD on sleep dysfunction, but did not significantly mediate the effect of GAD versus SAD on sleep dysfunction. Taken together, AS appears to be a more important predictor of sleep dysfunction overall, emphasizing the cross-diagnostic nature of AS and bolstering the RDoC initiative approach for treating psychological dysfunction.
authors.affiliation: a Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry , Massachusetts General Hospital , Boston , Massachusetts.|b Harvard Medical School , Boston , Massachusetts.
authors.forename: Amanda W
authors.initials: AW
authors.lastname: Baker
authors.affiliation: a Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry , Massachusetts General Hospital , Boston , Massachusetts.|b Harvard Medical School , Boston , Massachusetts.
authors.forename: Aparna
authors.initials: A
authors.lastname: Keshaviah
authors.affiliation: a Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry , Massachusetts General Hospital , Boston , Massachusetts.|b Harvard Medical School , Boston , Massachusetts.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Goetter
authors.affiliation: a Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry , Massachusetts General Hospital , Boston , Massachusetts.|b Harvard Medical School , Boston , Massachusetts.
authors.forename: Eric
authors.initials: E
authors.lastname: Bui
authors.affiliation: a Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry , Massachusetts General Hospital , Boston , Massachusetts.
authors.forename: Michaela
authors.initials: M
authors.lastname: Swee
authors.affiliation: a Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry , Massachusetts General Hospital , Boston , Massachusetts.
authors.forename: Peter L
authors.initials: PL
authors.lastname: Rosencrans
authors.affiliation: a Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry , Massachusetts General Hospital , Boston , Massachusetts.|b Harvard Medical School , Boston , Massachusetts.
authors.forename: Naomi M
authors.initials: NM
authors.lastname: Simon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D000072861:Phobia, Social / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D012890:Sleep; D012893:Sleep Wake Disorders / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology*; D011795:Surveys and Questionnaires; D055815:Young Adult