title: Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one in zebrafish embryos in vivo model.
abstract: In this study, trans-1,3-diphenyl-2,3-epoxypropane-1-one (DPEP) was evaluated for its anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated zebrafish embryos. In the present study, DPEP exhibited potential protective effect in the zebrafish embryos as confirmed by survival rate. DPEP acts as an effective agent against reactive oxygen species (ROS) formation induced by LPS. Moreover, DPEP effectively inhibited LPS-induced nitric oxide (NO) production in zebrafish embryos. In addition, DPEP significantly reduced the expression of inducible NOS (iNOS) and cycloxygenase 2 (COX-2), which generate NO as a key mediator of inflammation in a concentration-dependent manner. According to these results, DPEP could be considered an effective anti-inflammatory agent, which might be further developed as a functional ingredient. This is the first report of the anti-inflammatory activity of DPEP in the LPS-stimulated zebrafish model.
authors.affiliation: Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu 550-749, South Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Cheong
authors.affiliation: School of Marine Biomedical Sciences, Jeju National University, Jeju 690-756, South Korea.
authors.forename: Hye-Won
authors.initials: HW
authors.lastname: Yang
authors.affiliation: School of Marine Biomedical Sciences, Jeju National University, Jeju 690-756, South Korea; Jeju Center, Korea Basic Science Institute (KBSI), Jeju 690-140, South Korea.
authors.forename: Eun-Yi
authors.initials: EY
authors.lastname: Ko
authors.affiliation: Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu 550-749, South Korea.
authors.forename: Ginnae
authors.initials: G
authors.lastname: Ahn
authors.affiliation: School of Marine Biomedical Sciences, Jeju National University, Jeju 690-756, South Korea.
authors.forename: WonWoo
authors.initials: W
authors.lastname: Lee
authors.affiliation: Jeju Center, Korea Basic Science Institute (KBSI), Jeju 690-140, South Korea.
authors.forename: Daekyung
authors.initials: D
authors.lastname: Kim
authors.affiliation: School of Marine Biomedical Sciences, Jeju National University, Jeju 690-756, South Korea. Electronic address: youjinj@jejunu.ac.kr.
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
authors.affiliation: Jeju Center, Korea Basic Science Institute (KBSI), Jeju 690-140, South Korea; Department of Marin Biotechnology, University of Science and Technology, Daejeon 305-350, South Korea. Electronic address: knkim@kbsi.re.kr.
authors.forename: Kil-Nam
authors.initials: KN
authors.lastname: Kim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D051546:Cyclooxygenase 2 / Q000235:genetics* / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D004852:Epoxy Compounds / Q000494:pharmacology*; D029941:Fish Proteins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000008:administration & dosage; D009569:Nitric Oxide / Q000235:genetics* / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000235:genetics* / Q000378:metabolism; D011407:Propane / Q000031:analogs & derivatives* / Q000494:pharmacology; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D004852:Epoxy Compounds; D029941:Fish Proteins; D008070:Lipopolysaccharides; C582886:trans-1,3-diphenyl-2,3-epoxypropane-1-one; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2; D011407:Propane
keywords: Anti-inflammatory; LPS-Treatment; Trans-1,3-diphenyl-2,3-epoxypropan-1-one (DPEP); Zebrafish embryos