title: Can the Assessment of Spontaneous Oscillations by Near Infrared Spectrophotometry Predict Neurological Outcome of Preterm Infants?
abstract: The aim was to assess the correlation between cerebral autoregulation and outcome. Included were 31 preterm infants, gestational age 26 1/7 to 32 2/7 and <24 h life. Coherence between cerebral total haemoglobin (tHb) or oxygenation index (OI) measured by near-infrared spectrophotometry (NIRS) and systemic heart rate (HR) or arterial blood pressure (MAP) was calculated as a measure of autoregulation. In contrast to previous studies, low coherences in the first 24 h were significantly associated with intraventricular haemorrhage, death or abnormal neurodevelopmental outcome at 18 months or later. We suggest that our results can be explained by the concept of a multi-oscillatory-functions-order.
authors.affiliation: Division of Neonatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: André
authors.initials: A
authors.lastname: Stammwitz
authors.affiliation: Division of Neonatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Kurt
authors.initials: K
authors.lastname: von Siebenthal
authors.affiliation: Division of Neonatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Hans U
authors.initials: HU
authors.lastname: Bucher
authors.affiliation: Division of Neonatology, University Hospital Zurich, Zurich, Switzerland. martin.wolf@usz.ch.
authors.forename: Martin
authors.initials: M
authors.lastname: Wolf
mesh_terms: D062186:Arterial Pressure; D001921:Brain / Q000502:physiology*; D006339:Heart Rate; D006706:Homeostasis; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D010100:Oxygen
keywords: Autoregulation; Near infrared spectroscopy; Neurological outcome; Preterm infants; Spontaneous oscillations