title: Heparin-Induced-Thrombocytopenia Causing Massive Aortic Thrombosis after Ascending Aortic Replacement for Type A Acute Aortic Dissection.
abstract: A 77-year-old woman underwent emergency ascending aortic replacement for type A acute aortic dissection. Fifteen days after the operation, she had motor and sensory disturbances in the lower limbs. Computed tomography revealed multiple aortic thrombi and disrupted blood flow in the right external iliac and left common iliac arteries. She underwent an emergency thrombectomy for acute limb ischemia. Because heparin-induced-thrombocytopenia (HIT) was suspected to have caused the multiple aortic thrombi, we postoperatively changed the anticoagulant therapy from heparin to argatroban. Seventeen days after the first operation, gastrointestinal bleeding developed, and the patient died of mesenteric ischemia caused by HIT. Arterial embolization caused by HIT after cardiovascular surgery is a rare, but fatal event. To avoid fatal complications, early diagnosis and early treatment are essential. Use of a scoring system would probably facilitate early diagnosis.
authors.affiliation: Cardiovascular Center, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Matsuki
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Imoto
authors.forename: Keiji
authors.initials: K
authors.lastname: Uchida
authors.forename: Susumu
authors.initials: S
authors.lastname: Isoda
authors.forename: Norihisa
authors.initials: N
authors.lastname: Karube
authors.forename: Shota
authors.initials: S
authors.lastname: Yasuda
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
mesh_terms: D000208:Acute Disease; D000368:Aged; D000784:Aortic Dissection / Q000000981:diagnostic imaging / Q000601:surgery*; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001014:Aortic Aneurysm / Q000000981:diagnostic imaging / Q000601:surgery*; D001018:Aortic Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D001027:Aortography / Q000379:methods; D001120:Arginine / Q000031:analogs & derivatives; D019917:Blood Vessel Prosthesis Implantation; D000072226:Computed Tomography Angiography; D057915:Drug Substitution; D004630:Emergencies; D017809:Fatal Outcome; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D065666:Mesenteric Ischemia / Q000209:etiology; D010875:Pipecolic Acids / Q000008:administration & dosage; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013927:Thrombosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban