title: A dramatic enhancing effect of InBr3 towards the oxidative Sonogashira cross-coupling reaction of 2-ethynylanilines.
abstract: The addition of InBr3 to the oxidative Sonogashira cross-coupling reaction of 2-ethynylaniline with (E)-trimethyl(3,3,3-trifluoroprop-1-enyl)silane led to a dramatic increase in the reactivity to afford the corresponding 1,3-enynes bearing a trifluoromethyl group on their terminal sp(2) carbon. The subsequent cyclization of these 1,3-enynes under palladium catalysis provides access to the corresponding indoles bearing a 3,3,3-trifluoroprop-1-enyl group at their 2-position.
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. aando@pharm.setsunan.ac.jp.
authors.forename: A
authors.initials: A
authors.lastname: Ikeda
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. aando@pharm.setsunan.ac.jp.
authors.forename: M
authors.initials: M
authors.lastname: Omote
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. aando@pharm.setsunan.ac.jp.
authors.forename: K
authors.initials: K
authors.lastname: Kusumoto
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. aando@pharm.setsunan.ac.jp.
authors.forename: M
authors.initials: M
authors.lastname: Komori
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. aando@pharm.setsunan.ac.jp.
authors.forename: A
authors.initials: A
authors.lastname: Tarui
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. aando@pharm.setsunan.ac.jp.
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. aando@pharm.setsunan.ac.jp.
authors.forename: A
authors.initials: A
authors.lastname: Ando