title: The mechanical response of the porcine lens to a spinning test.
abstract: The pig lens has been used as a model for presbyopia as pigs lack accommodative ability. Previous studies using microindentation have indicated that the shear modulus distribution is qualitatively similar to that of the aged human lens and that the lens does not alter its refractive power due to equatorial stretching. A lens spinning test was used to determine whether prior lens stiffness data obtained from a sectioned porcine lens were reliable and whether the testing conditions significantly influence the lens' mechanical properties. The elastic modulus distribution determined for fresh lenses closely matched that measured previously using a microindentation test. Confocal scanning laser microscopy was used to evaluate changes to the lens' structure arising from mechanical stress and following storage for up to one week.
authors.affiliation: Department of Biomedical Engineering, Ohio State University, 270 Bevis Hall, 1080 Carmack Rd, Columbus, OH 43210, United States. Electronic address: reilly.196@osu.edu.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Reilly
authors.affiliation: Department of Ophthalmology, University of Rostock, Doberaner Strasse 140, 18057 Rostock, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Martius
authors.affiliation: Department of Biomedical Engineering, Ohio State University, 270 Bevis Hall, 1080 Carmack Rd, Columbus, OH 43210, United States.
authors.forename: Saurav
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, United Kingdom.
authors.forename: Harvey J
authors.initials: HJ
authors.lastname: Burd
authors.affiliation: Department of Ophthalmology, University of Rostock, Doberaner Strasse 140, 18057 Rostock, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Stachs
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology*; D020342:Finite Element Analysis; D006245:Hardness Tests / Q000379:methods*; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000503:physiopathology*; D018613:Microscopy, Confocal / Q000379:methods*; D008954:Models, Biological; D015203:Reproducibility of Results; D012399:Rotation; D012680:Sensitivity and Specificity; D033081:Shear Strength / Q000502:physiology; D013314:Stress, Mechanical; D013552:Swine
keywords: Akkommodation; Auge; Eye; Lagerung; Linseneigenschaften; Presbyopie; accommodation; lens properties; lens spinning; lens storage; presbyopia