title: Direct Recordings from Human Anterior Insula Reveal its Leading Role within the Error-Monitoring Network.
abstract: The ability to monitor our own errors is mediated by a network that includes dorsomedial prefrontal cortex (dmPFC) and anterior insula (AI). However, the dynamics of the underlying neurophysiological processes remain unclear. In particular, whether AI is on the receiving or driving end of the error-monitoring network is unresolved. Here, we recorded intracerebral electroencephalography signals simultaneously from AI and dmPFC in epileptic patients while they performed a stop-signal task. We found that errors selectively modulated broadband neural activity in human AI. Granger causality estimates revealed that errors were immediately followed by a feedforward influence from AI onto anterior cingulate cortex and, subsequently, onto presupplementary motor area. The reverse pattern of information flow was observed on correct responses. Our findings provide the first direct electrophysiological evidence indicating that the anterior insula rapidly detects and conveys error signals to dmPFC, while the latter might use this input to adapt behavior following inappropriate actions.
authors.affiliation: University of Grenoble Alpes, F-38000 Grenoble, France.|Inserm, U1216, F-38000 Grenoble, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Bastin
authors.affiliation: University of Grenoble Alpes, F-38000 Grenoble, France.|Inserm, U1216, F-38000 Grenoble, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Deman
authors.affiliation: University of Grenoble Alpes, F-38000 Grenoble, France.|Inserm, U1216, F-38000 Grenoble, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: David
authors.affiliation: University of Grenoble Alpes, F-38000 Grenoble, France.|Inserm, U1216, F-38000 Grenoble, France.
authors.forename: Maëlle
authors.initials: M
authors.lastname: Gueguen
authors.affiliation: University of Grenoble Alpes, F-38000 Grenoble, France.|Inserm, U1216, F-38000 Grenoble, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Benis
authors.affiliation: Inserm, U1216, F-38000 Grenoble, France.|Neurology Department, CHU de Grenoble, Hôpital Michallon, F-38000 Grenoble, France.
authors.forename: Lorella
authors.initials: L
authors.lastname: Minotti
authors.affiliation: Neurology Department, CHU de Grenoble, Hôpital Michallon, F-38000 Grenoble, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Hoffman
authors.affiliation: Center of Research and Innovation in Sport, Mental Processes and Motor Performance, University of Lyon I, Lyon, France.|DYCOG Lab, Lyon Neuroscience Research Center, INSERM U1028, UMR 5292, University Lyon I, Lyon, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Combrisson
authors.affiliation: Department of Neuroscience and Biomedical Engineering, Aalto University, 02150 Espoo, Finland.
authors.forename: Jan
authors.initials: J
authors.lastname: Kujala
authors.affiliation: University of Grenoble Alpes, F-38000 Grenoble, France.|CNRS, LPNC, UMR 5105, F-38040 Grenoble, France.
authors.forename: Marcela
authors.initials: M
authors.lastname: Perrone-Bertolotti
authors.affiliation: Inserm, U1216, F-38000 Grenoble, France.|Neurology Department, CHU de Grenoble, Hôpital Michallon, F-38000 Grenoble, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Kahane
authors.affiliation: DYCOG Lab, Lyon Neuroscience Research Center, INSERM U1028, UMR 5292, University Lyon I, Lyon, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Lachaux
authors.affiliation: DYCOG Lab, Lyon Neuroscience Research Center, INSERM U1028, UMR 5292, University Lyon I, Lyon, France.|Psychology Department, University of Montreal, Montreal, QC, Canada.
authors.forename: Karim
authors.initials: K
authors.lastname: Jerbi
mesh_terms: D000328:Adult; D001931:Brain Mapping; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time
keywords: EcoG; anterior cingulate cortex; gamma; performance monitoring; saliency