title: Structural insights of mTOR complex 1.
abstract: The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin, is a central cell growth regulating kinase that forms large molecular complexes in all eukaryotic cells. A paper recently published in Science reports the architecture of mTOR complex 1 (mTORC1) and provides molecular insights into the regulation and substrate selectivity of mTORC1.
authors.affiliation: Molecular Cell Biology Laboratory, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors.forename: Hai-Xin
authors.initials: HX
authors.lastname: Yuan
authors.affiliation: Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Kun-Liang
authors.initials: KL
authors.lastname: Guan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry*; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry*; D058570:TOR Serine-Threonine Kinases / Q000737:chemistry*; D022021:Tacrolimus Binding Proteins / Q000737:chemistry*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D046912:Multiprotein Complexes; D058570:TOR Serine-Threonine Kinases; D022021:Tacrolimus Binding Proteins