title: The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation.
abstract: Commensal microbes are necessary for a healthy gut immune system. However, the mechanism involving these microbes that establish and maintain gut immune responses is largely unknown. Here, we have found that the gut immune receptor leucine-rich repeat (LRR) C19 is involved in host-microbiota interactions. LRRC19 deficiency not only impairs the gut immune system but also reduces inflammatory responses in gut tissues. We demonstrate that the LRRC19-associated chemokines CCL6, CCL9, CXCL9, and CXCL10 play a critical role in immune cell recruitment and intestinal inflammation. The expression of these chemokines is associated with regenerating islet-derived (REG) protein-mediated microbiotas. We also found that the expression of REGs may be regulated by gut Lactobacillus through LRRC19-mediated activation of NF-κB. Therefore, our study establishes a regulatory axis of LRRC19, REGs, altered microbiotas, and chemokines for the recruitment of immune cells and the regulation of intestinal inflammation.
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Shuisong
authors.initials: S
authors.lastname: Cao
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Su
authors.affiliation: Department of Laboratory Animal Science, College of Basic Medicine Science, Third Military Medical University, Chongqing 404100, China.
authors.forename: Benhua
authors.initials: B
authors.lastname: Zeng
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Yugang
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Enlin
authors.initials: E
authors.lastname: Wang
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Yun
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Laboratory Animal Science, College of Basic Medicine Science, Third Military Medical University, Chongqing 404100, China.
authors.forename: Wenxia
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Laboratory Animal Science, College of Basic Medicine Science, Third Military Medical University, Chongqing 404100, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
authors.forename: Yongzhe
authors.initials: Y
authors.lastname: Che
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China; Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China. Electronic address: ryang@nankai.edu.cn.
authors.forename: Rongcun
authors.initials: R
authors.lastname: Yang
mesh_terms: D000818:Animals; D018925:Chemokines / Q000235:genetics / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D007778:Lactobacillus / Q000302:isolation & purification / Q000378:metabolism; D051847:Lithostathine / Q000235:genetics / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D064307:Microbiota; D016328:NF-kappa B / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*
chemical_list: D018925:Chemokines; C544175:LRRC19 protein, mouse; D051847:Lithostathine; D016328:NF-kappa B; D011956:Receptors, Cell Surface