title: 2-(2-Phenylethyl)chromone derivatives in artificial agarwood from Aquilaria sinensis.
abstract: Seven new 2-(2-phenylethyl)chromone derivatives (1-7) including a chlorinated one (4), together with eight known ones (8-15), were isolated from the EtOAc extract of artificial agarwood originating from Aquilaria sinensis (Lour.) Gilg. All structures including the absolute configurations were unambiguously elucidated by spectroscopic (NMR, UV, IR, MS) methods, Mosher's method, and comparison with reported data in the literatures. Among those, compounds 8, 12, and 14 exhibited significant inhibition against α-glucosidase in vitro with IC50 values of 0.15, 0.05, and 0.09 mM, respectively (with acarbose as the positive control; IC50: 0.98 mM). In addition, compounds 3, 9, 11, and 14 showed weak inhibitory activity against AChE; and compounds 12 and 13 displayed weak cytotoxicity against human gastric cell line (SGC-7901) among three types of tested human cancer cell lines (BEL-7402, K562, and SGC-7901).
authors.affiliation: College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, PR China.
authors.forename: Ge
authors.initials: G
authors.lastname: Liao
authors.affiliation: Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.affiliation: Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Dong
authors.affiliation: Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.affiliation: Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Fan-Dong
authors.initials: FD
authors.lastname: Kong
authors.affiliation: Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors.forename: Cui-Juan
authors.initials: CJ
authors.lastname: Gai
authors.affiliation: College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, PR China. Electronic address: songstrong@hainu.edu.cn.
authors.forename: Xi-Qiang
authors.initials: XQ
authors.lastname: Song
authors.affiliation: Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China. Electronic address: daihaofu@itbb.org.cn.
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D029645:Thymelaeaceae / Q000737:chemistry*; D014934:Wood / Q000737:chemistry; D000520:alpha-Glucosidases
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; C062550:2-(2-phenylethyl)chromone; D000520:alpha-Glucosidases
keywords: 2-(2-Phenylethyl)chromone; Agarwood; Aquilaria sinensis; Biological activity