title: [The mechanism of miRNA-mediated PGR signaling pathway in regulating female reproduction].
abstract: MicroRNAs (miRNAs) are involved in several physiological processes as important post-transcriptional regulators. Progesterone (P4), an important steroid hormone, produces physiological effect through binding specific receptor progesterone receptors (PGR) which regulates functions of both reproductive and non-reproductive tissues as a member of the nuclear receptor superfamily. P4/PGR and miRNAs could regulate female reproduction independently, however, it is still unclear how miRNAs and P4/PGR interaction regulates female reproductive activities such as ovulation in female reproduction. In this review, we summarize the possible ways in which miRNAs regulate P4 production and PGR gene expression as well as P4/PGR regulate miRNAs expression, which provide a theoretical basis for further studying the role of miRNAs and P4/PGR in female reproduction.
authors.affiliation: Bioengineering Institute of Chongqing University, Chongqing 400030, China.
authors.forename: Long
authors.initials: L
authors.lastname: Chen
authors.affiliation: Bioengineering Institute of Chongqing University, Chongqing 400030, China.
authors.forename: Bao-yun
authors.initials: BY
authors.lastname: Zhang
authors.affiliation: Sichuan TQLS Animal Husbandry Science and Technology Co., LTD, Mianyang 621000, China.
authors.forename: Guang-de
authors.initials: GD
authors.lastname: Feng
authors.affiliation: Bioengineering Institute of Chongqing University, Chongqing 400030, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiang
authors.affiliation: Bioengineering Institute of Chongqing University, Chongqing 400030, China.
authors.forename: Yun-xia
authors.initials: YX
authors.lastname: Ma
authors.affiliation: Bioengineering Institute of Chongqing University, Chongqing 400030, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Chen
authors.affiliation: Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
authors.forename: Ming-xing
authors.initials: MX
authors.lastname: Chu
authors.affiliation: Bioengineering Institute of Chongqing University, Chongqing 400030, China.
authors.forename: Ping-qing
authors.initials: PQ
authors.lastname: Wang
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism*; D012098:Reproduction; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D011980:Receptors, Progesterone; D011374:Progesterone