title: PARP inhibition in castration-resistant prostate cancer.
authors.affiliation: Vancouver Prostate Centre & Department of Urologic Science, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Lucia
authors.initials: L
authors.lastname: Nappi
authors.affiliation: Vancouver Prostate Centre & Department of Urologic Science, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Gleave
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers; D004260:DNA Repair / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D009154:Mutation; D000067856:Poly(ADP-ribose) Polymerase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D000067856:Poly(ADP-ribose) Polymerase Inhibitors
keywords: DNA repair gene mutations; PARP inhibitors; castration-resistant prostate cancer; gene sequencing; targeted therapy