title: Preparation of multiparticulate systems for oral delivery of a micronized or nanosized poorly soluble drug.
abstract: The purpose of the present work was to prepare multiparticulate drug delivery systems for oral administration of a poorly soluble drug such as itraconazole. Multiparticulate systems were prepared by extrusion/spheronization technique using a mix of crospovidone, low viscosity hypromellose, microcrystalline cellulose, micronized drug and water. In order to improve the release performance of the multiparticulate systems, the micronized drug was suspended in water with polysorbate 20 and nanonized by a high-pressure homogenization. The suspension of drug nanoparticles was then spray-dried for enabling an easy handling of the drug and for preventing the over-wetting of the powders during extrusion/spheronization processing. Both multiparticulate units prepared with micronized or nanonized drug showed acceptable disintegrating properties. The nanosizing of micronized drug powder provided a significant improvement of drug dissolution rates of the multiparticulates.
authors.affiliation: a Dipartimento Di Scienze Farmaceutiche , Università Degli Studi Di Milano , Milano , Italy ;|b Pharmaceutical Technologies & Development , Veruno , Italy ;
authors.forename: Matteo
authors.initials: M
authors.lastname: Cerea
authors.affiliation: c Dipartimento Di Scienze Del Farmaco , Università Degli Studi Del Piemonte Orientale "a. Avogadro" , Novara , Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Pattarino
authors.affiliation: c Dipartimento Di Scienze Del Farmaco , Università Degli Studi Del Piemonte Orientale "a. Avogadro" , Novara , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Foglio Bonda
authors.affiliation: a Dipartimento Di Scienze Farmaceutiche , Università Degli Studi Di Milano , Milano , Italy ;
authors.forename: Luca
authors.initials: L
authors.lastname: Palugan
authors.affiliation: c Dipartimento Di Scienze Del Farmaco , Università Degli Studi Del Piemonte Orientale "a. Avogadro" , Novara , Italy.
authors.forename: Lorena
authors.initials: L
authors.lastname: Segale
authors.affiliation: b Pharmaceutical Technologies & Development , Veruno , Italy ;
authors.forename: Carlo
authors.initials: C
authors.lastname: Vecchio
mesh_terms: D000284:Administration, Oral; D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods; D065347:Hypromellose Derivatives / Q000737:chemistry; D017964:Itraconazole / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011136:Polysorbates / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D011208:Powders / Q000737:chemistry; D012995:Solubility; D013535:Suspensions / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D011136:Polysorbates; D011208:Powders; D013535:Suspensions; D014867:Water; D017964:Itraconazole; D065347:Hypromellose Derivatives; D002482:Cellulose; D011205:Povidone; C109691:microcrystalline cellulose
keywords: Extrusion and spheronization; high-pressure homogenization; itraconazole; multiparticulate; nanonization; poorly soluble drug; spray drying