title: [A Case of Locally Advanced Breast Cancer Treated with Modified Radical Mastectomy with Immediate Reconstruction Using a Tissue Expander after Endocrine Therapy].
abstract: We experienced a case of locally advanced breast cancer treated with modified radical mastectomy with immediate reconstruction using a tissue expander after endocrine therapy. A 64-year-old postmenopausal woman had a 50 mm tumor in her right breast with extensive reddening of the skin. She had axillary lymph node metastasis. Core needle biopsy showed invasive ductal carcinoma with positive hormone receptor (ER+, PgR+) and negative HER2 status. The patient was diagnosed with locally-advanced breast cancer (cT4bN1M0, stage ⅢB). She was treated with anastrozole at a dose of 1 mg per day. The tumor decreased in size gradually and became operable after 7 months of anastrozole monotherapy. She underwent modified radical mastectomy with immediate reconstruction using a tissue expander. The resected specimen was a 30 mm tumor; adverse effects due to endocrine therapy were of Grade 1a severity. Seven months after adjuvant chemotherapy (FEC→DTX), the tissue expander was removed, and the right breast was reconstructed using an implant. No complications were noted, and the patient was treated with radiation therapy. Ten months have passed since surgery, and no local recurrence or distant metastasis has been noted.
authors.affiliation: Dept. of Surgery, Fuchu Hospital.
authors.forename: Naoki
authors.initials: N
authors.lastname: Aomatsu
authors.forename: Seika
authors.initials: S
authors.lastname: Tei
authors.forename: Goichi
authors.initials: G
authors.lastname: Haraoka
authors.forename: Kosuke
authors.initials: K
authors.lastname: Hosoi
authors.forename: Naho
authors.initials: N
authors.lastname: Fujii
authors.forename: Gen
authors.initials: G
authors.lastname: Tsujio
authors.forename: Soichiro
authors.initials: S
authors.lastname: Hiramatsu
authors.forename: En
authors.initials: E
authors.lastname: Wang
authors.forename: Takehiko
authors.initials: T
authors.lastname: Iwauchi
authors.forename: Junya
authors.initials: J
authors.lastname: Morimoto
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nishii
authors.forename: Kinshi
authors.initials: K
authors.lastname: Kosaka
authors.forename: Yasutake
authors.initials: Y
authors.lastname: Uchima
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takeuchi
mesh_terms: D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D062005:Biopsy, Large-Core Needle; D018427:Breast Implants; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use; D015625:Tissue Expansion Devices; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole