title: Controlled release of diclofenac sodium from polylactide acid-based solid dispersions prepared by hot-melt extrusion.
abstract: In this paper, hot-melt extrusion was applied to prepare drug delivery systems using polylactide acid (PLA) as the matrix. Diclofenac sodium (DS) was used as a model drug. Polyethylene glycol (PEG, molecular weight is 6000) and sodium dodecyl sulfate (SDS) were used as the release rate modifiers. For the PLA/PEG/DS blends, the release of DS was enhanced with higher amounts of PEG and DS. After the addition of SDS to the PLA/PEG/DS blends, the dispersion of DS and PEG was significantly improved. Compared to the PLA/PEG/DS blends with the same drug loading, the drug release behavior of PLA/PEG/DS/SDS was remarkably suppressed due to the presence of SDS. And a controllable linear release of DS was achieved.
authors.affiliation: a The State Key Laboratory of Polymer Materials Engineering , Polymer Research Institute of Sichuan University , Chengdu , China.
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
authors.affiliation: a The State Key Laboratory of Polymer Materials Engineering , Polymer Research Institute of Sichuan University , Chengdu , China.
authors.forename: Genlin
authors.initials: G
authors.lastname: Li
authors.affiliation: a The State Key Laboratory of Polymer Materials Engineering , Polymer Research Institute of Sichuan University , Chengdu , China.
authors.forename: Aichun
authors.initials: A
authors.lastname: Han
authors.affiliation: a The State Key Laboratory of Polymer Materials Engineering , Polymer Research Institute of Sichuan University , Chengdu , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.affiliation: a The State Key Laboratory of Polymer Materials Engineering , Polymer Research Institute of Sichuan University , Chengdu , China.
authors.forename: Shaoyun
authors.initials: S
authors.lastname: Guo
mesh_terms: D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D006358:Hot Temperature; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D004008:Diclofenac; C000595215:Polyethylene Glycol 6000; D012967:Sodium Dodecyl Sulfate; D011092:Polyethylene Glycols; C033616:poly(lactide)
keywords: Polylactide acid; controlled release; diclofenac sodium; hot-melt extrusion; sodium dodecyl sulfate