title: Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection.
abstract: Animals behave differently in response to visual cues with distinct ethological meaning, a process usually thought to be achieved through differential visual processing. Using a defined zebrafish escape circuit as a model, we found that behavior selection can be implemented at the visuomotor transformation stage through a visually responsive dopaminergic-inhibitory circuit module. In response to non-threatening visual stimuli, hypothalamic dopaminergic neurons and their positively regulated hindbrain inhibitory interneurons increase activity, suppressing synaptic transmission from the visual center to the escape circuit. By contrast, threatening visual stimuli inactivate some of these neurons, resulting in dis-inhibition of the visuomotor transformation and escape generation. The distinct patterns of dopaminergic-inhibitory neural module's visual responses account for this stimulus-specific visuomotor transformation and behavioral control. Thus, our study identifies a behavioral relevance-dependent mechanism that controls visuomotor transformation and behavior selection and reveals that neuromodulation can be tuned by visual cues to help animals generate appropriate responses.
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science & Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; Graduate School, University of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science & Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science & Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; Graduate School, University of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.
authors.forename: Baibing
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science & Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; Graduate School, University of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yin
authors.affiliation: Britton Chance Center for Biomedical Photonics and Department of Biomedical Engineering, Huazhong University of Science and Technology-Wuhan National Laboratory for Optoelectronics, Wuhan 430074, China.
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science & Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; Graduate School, University of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.
authors.forename: Weiyu
authors.initials: W
authors.lastname: Chen
authors.affiliation: Britton Chance Center for Biomedical Photonics and Department of Biomedical Engineering, Huazhong University of Science and Technology-Wuhan National Laboratory for Optoelectronics, Wuhan 430074, China.
authors.forename: Shaoqun
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science & Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; Graduate School, University of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, 319 Yue-Yang Road, Shanghai 200031, China. Electronic address: forestdu@ion.ac.cn.
authors.forename: Jiulin
authors.initials: J
authors.lastname: Du
mesh_terms: D000818:Animals; D003463:Cues; D004192:Discrimination, Psychological / Q000502:physiology*; D059290:Dopaminergic Neurons / Q000502:physiology*; D005239:Fear / Q000502:physiology*; D005998:Glycine / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D007395:Interneurons / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D010775:Photic Stimulation; D012249:Rhombencephalon / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*; D015027:Zebrafish
chemical_list: D005998:Glycine