title: Dual-coated lactic acid bacteria: an emerging innovative technology in the field of probiotics.
abstract: Probiotics are living micro-organisms that do not naturally have shelf life, and normally are weakly protected against the digestive action of the GI tract. A new dual coating technology has been developed in an effort to maximize survival, that is, to be able to reach the intestine alive and in sufficient numbers to confer the beneficial health effects on the host. Dual-coating of lactic acid bacteria (LAB) is the result of fourth-generation coating technology for the protection of these bacteria at least 100-fold or greater than the uncoated LAB. This innovative technique involves a first pH-dependent protein layer that protects bacteria from gastric acid and bile salt, and a second polysaccharide matrix that protects bacteria from external factors, such as humidity, temperature and pressure, as well as the digestive action during the passage through the GI tract. Dual-coated probiotic formulation is applicable to different therapeutic areas, including irritable bowel syndrome, atopic dermatitis, acute diarrhea, chronic constipation, Helicobacter pylori eradication, and prevention of antibiotic-associated diarrhea. An updated review of the efficacy of doubly coated probiotic strains for improving bacterial survival in the intestinal tract and its consequent clinical benefits in humans is here presented.
authors.affiliation: Department of Pediatric Gastroenterology & Nutrition. Gregorio Marañon Hospital. Madrid, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Alvarez-Calatayud
authors.affiliation: Department of Microbiology and Biochemistry of Dairy Products. Dairy Research Institute of Asturias (IPLA-CSIC). Villaviciosa, Asturias, Spain.
authors.forename: Abelardo
authors.initials: A
authors.lastname: Margolles
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects; D003248:Constipation / Q000628:therapy; D003876:Dermatitis, Atopic / Q000628:therapy; D003967:Diarrhea / Q000517:prevention & control / Q000628:therapy; D005744:Gastric Acid; D041981:Gastrointestinal Tract / Q000382:microbiology / Q000502:physiology*; D016480:Helicobacter pylori; D006801:Humans; D006863:Hydrogen-Ion Concentration; D043183:Irritable Bowel Syndrome / Q000628:therapy; D056546:Lactobacillales / Q000502:physiology*; D050296:Microbial Viability; D011134:Polysaccharides / Q000737:chemistry; D019936:Probiotics / Q000737:chemistry / Q000627:therapeutic use; D011506:Proteins / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D011134:Polysaccharides; D011506:Proteins
keywords: antibiotic-related diarrhea; atopic dermatitis; diarrhea; dual-coated probiotic formulation; irritable bowel syndrome; lactic acid bacteria; probiotics