title: Toxocara canis: Larvicidal activity of fatty acid amides.
abstract: Considering the therapeutic potential of fatty acid amides, the present study aimed to evaluate their in vitro activity against Toxocara canis larvae and their cytotoxicity for the first time. Linoleylpyrrolidilamide was the most potent, with a minimal larvicidal concentration (MLC) of 0.05 mg/mL and 27% cytotoxicity against murine peritoneal macrophages C57BL/6 mice, as assessed by the MTT assay.
authors.affiliation: Parasitology Laboratory, Faculty of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil. Electronic address: farmatais@hotmail.com.
authors.forename: Taís
authors.initials: T
authors.lastname: Mata-Santos
authors.affiliation: Laboratory Kolbe of Organic Synthesis, School of Chemistry and Food, Universidade Federal do Rio Grande, Rio Grande, Brazil.
authors.forename: Caroline da Ros Montes
authors.initials: CDRM
authors.lastname: D'Oca
authors.affiliation: Department of Clinical and Toxicological Analysis, Pharmacy College, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Hílton Antônio
authors.initials: HA
authors.lastname: Mata-Santos
authors.affiliation: Parasitology Laboratory, Faculty of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Fenalti
authors.affiliation: Parasitology Laboratory, Faculty of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil.
authors.forename: Nitza
authors.initials: N
authors.lastname: Pinto
authors.affiliation: Center for Research and Medical Microbiology, Faculty of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil.
authors.forename: Tatiane
authors.initials: T
authors.lastname: Coelho
authors.affiliation: Department of Microbiology and Parasitology, Institute of Biology, Universidade Federal de Pelotas, Pelotas, Brazil.
authors.forename: Maria Elisabeth
authors.initials: ME
authors.lastname: Berne
authors.affiliation: Center for Research and Medical Microbiology, Faculty of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil.
authors.forename: Pedro Eduardo Almeida
authors.initials: PEA
authors.lastname: da Silva
authors.affiliation: Laboratory Kolbe of Organic Synthesis, School of Chemistry and Food, Universidade Federal do Rio Grande, Rio Grande, Brazil.
authors.forename: Marcelo Gonçalves Montes
authors.initials: MGM
authors.lastname: D'Oca
authors.affiliation: Parasitology Laboratory, Faculty of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil.
authors.forename: Carlos James
authors.initials: CJ
authors.lastname: Scaini
mesh_terms: D000577:Amides / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology*; D005227:Fatty Acids / Q000737:chemistry*; D007814:Larva / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D017166:Toxocara canis / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000577:Amides; D000981:Antiprotozoal Agents; D005227:Fatty Acids
keywords: Chemical compounds; Chemotherapy; Cytotoxicity; Toxocarosis