title: Functional and pathological relevance of HERC family proteins: a decade later.
abstract: The HERC gene family encodes proteins with two characteristic domains in their sequence: the HECT domain and the RCC1-like domain (RLD). In humans, the HERC family comprises six members that can be divided into two groups based on their molecular mass and domain structure. Whereas large HERCs (HERC1 and HERC2) contain one HECT and more than one RLD, small HERCs (HERC3-6) possess single HECT and RLD domains. Accumulating evidence shows the HERC family proteins to be key components of a wide range of cellular functions, including neurodevelopment, DNA damage repair, cell growth and immune response. Considering the significant recent advances made regarding HERC functionality, an updated review summarizing the progress is greatly needed at 10 years since the last HERC review. We provide an integrated view of HERC function and go into detail about its implications for several human diseases such as cancer and neurological disorders.
authors.affiliation: Departament de Ciències Fisiològiques II, Campus de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Universitat de Barcelona, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Sánchez-Tena
authors.affiliation: Departament de Ciències Fisiològiques II, Campus de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Universitat de Barcelona, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
authors.forename: Monica
authors.initials: M
authors.lastname: Cubillos-Rojas
authors.affiliation: Departament de Ciències Fisiològiques II, Campus de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Universitat de Barcelona, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
authors.forename: Taiane
authors.initials: T
authors.lastname: Schneider
authors.affiliation: Departament de Ciències Fisiològiques II, Campus de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Universitat de Barcelona, L'Hospitalet de Llobregat, 08907, Barcelona, Spain. joseluisrosa@ub.edu.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Rosa
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology; D020662:Guanine Nucleotide Exchange Factors / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000502:physiology; D005810:Multigene Family; D017434:Protein Structure, Tertiary; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D020662:Guanine Nucleotide Exchange Factors; C402395:HERC5 protein, human; D047908:Intracellular Signaling Peptides and Proteins; C502268:HERC4 protein, human; C502269:HERC6 protein, human; C102169:HERC1 protein, human; C118566:HERC2 protein, human; C406215:HERC3 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: HECT; HERC proteins; RCC1; RLD; Ubiquitin ligase