title: Water-Borne Endovascular Embolics Inspired by the Undersea Adhesive of Marine Sandcastle Worms.
abstract: Transcatheter embolization is used to treat vascular malformations and defects, to control bleeding, and to selectively block blood supply to tissues. Liquid embolics are used for small vessel embolization that require distal penetration. Current liquid embolic agents have serious drawbacks, mostly centered around poor handling characteristics and toxicity. In this work, a water-borne in situ setting liquid embolic agent is described that is based on electrostatically condensed, oppositely charged polyelectrolytes-complex coacervates. At high ionic strengths, the embolic coacervates are injectable fluids that can be delivered through long narrow microcatheters. At physiological ionic strength, the embolic coacervates transition into a nonflowing solid morphology. Transcatheter embolization of rabbit renal arteries demonstrated capillary level penetration, homogeneous occlusion, and 100% devascularization of the kidney, without the embolic crossing into venous circulation. The benign water-borne composition and setting mechanism avoids many of the problems of current liquid embolics, and provides precise temporal and spatial control during endovascular embolization.
authors.affiliation: Department of Bioengineering, University of Utah, Salt Lake City, UT, 84112, USA.
authors.forename: Joshua P
authors.initials: JP
authors.lastname: Jones
authors.affiliation: Department of Bioengineering, University of Utah, Salt Lake City, UT, 84112, USA.
authors.forename: Monika
authors.initials: M
authors.lastname: Sima
authors.affiliation: Department of Radiology, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
authors.forename: Ryan G
authors.initials: RG
authors.lastname: O'Hara
authors.affiliation: Department of Bioengineering, University of Utah, Salt Lake City, UT, 84112, USA.
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Stewart
mesh_terms: D000269:Adhesives / Q000494:pharmacology*; D000818:Animals; D000845:Annelida / Q000737:chemistry*; D059001:Aquatic Organisms / Q000737:chemistry*; D004621:Embolization, Therapeutic; D057510:Endovascular Procedures; D007267:Injections; D009792:Oceans and Seas; D009994:Osmolar Concentration; D011312:Pressure; D011817:Rabbits; D012077:Renal Artery / Q000187:drug effects / Q000473:pathology; D012212:Rheology; D014783:Viscosity; D014867:Water / Q000737:chemistry*
chemical_list: D000269:Adhesives; D014867:Water
keywords: complex coacervates; condensed polyelectrolytes; embolic agents; renal embolization