title: PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation.
abstract: Long-term consolidation of memories depends on processes occurring many hours after acquisition. Whether this involves plasticity that is specifically required for long-term consolidation remains unclear. We found that learning-induced plasticity of local parvalbumin (PV) basket cells was specifically required for long-term, but not short/intermediate-term, memory consolidation in mice. PV plasticity, which involves changes in PV and GAD67 expression and connectivity onto PV neurons, was regulated by cAMP signaling in PV neurons. Following induction, PV plasticity depended on local D1/5 dopamine receptor signaling at 0-5 h to regulate its magnitude, and at 12-14 h for its continuance, ensuring memory consolidation. D1/5 dopamine receptor activation selectively induced DARPP-32 and ERK phosphorylation in PV neurons. At 12-14 h, PV plasticity was required for enhanced sharp-wave ripple densities and c-Fos expression in pyramidal neurons. Our results reveal general network mechanisms of long-term memory consolidation that requires plasticity of PV basket cells induced after acquisition and sustained subsequently through D1/5 receptor signaling.
authors.affiliation: Friedrich Miescher Institut, Basel, Switzerland.
authors.forename: Smitha
authors.initials: S
authors.lastname: Karunakaran
authors.affiliation: Friedrich Miescher Institut, Basel, Switzerland.
authors.forename: Ananya
authors.initials: A
authors.lastname: Chowdhury
authors.affiliation: Friedrich Miescher Institut, Basel, Switzerland.
authors.forename: Flavio
authors.initials: F
authors.lastname: Donato
authors.affiliation: Neuroscience Department of the Medical Faculty and Center for Biomedical Imaging, University of Geneva, Geneva, Switzerland.
authors.forename: Charles
authors.initials: C
authors.lastname: Quairiaux
authors.affiliation: Neuroscience Department of the Medical Faculty and Center for Biomedical Imaging, University of Geneva, Geneva, Switzerland.
authors.forename: Christoph M
authors.initials: CM
authors.lastname: Michel
authors.affiliation: Friedrich Miescher Institut, Basel, Switzerland.
authors.forename: Pico
authors.initials: P
authors.lastname: Caroni
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32 / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D000069077:Memory Consolidation; D057567:Memory, Long-Term / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D051379:Mice; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D010320:Parvalbumins / Q000378:metabolism*; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D050641:Receptors, Dopamine D5 / Q000502:physiology*; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D010320:Parvalbumins; C497929:Ppp1r1b protein, mouse; D017447:Receptors, Dopamine D1; D050641:Receptors, Dopamine D5; D000242:Cyclic AMP; D048049:Extracellular Signal-Regulated MAP Kinases; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1