title: Platelet parameters (PLT, MPV, P-LCR) in patients with schizophrenia, unipolar depression and bipolar disorder.
abstract: There are no studies comparing platelet parameters platelet parameters (platelet count (PLT), mean platelet volume (MPV) and platelet large cell ratio (P-LCR)) between patients with schizophrenia, bipolar disorder and unipolar depression. Therefore, the aim of this study was to determine and compare differences in PLT, MPV and P-LCR in patients with schizophrenia, unipolar depression and bipolar disorder. This was a retrospective, cross-sectional, naturalistic study of 2377 patients (schizophrenia n=1243; unipolar depression n=791; bipolar disorder n=343, including bipolar depression n=259 and mania n=84). There were significant differences for PLT, MPV and P-LCR values between study groups. A significant percentage of patients with bipolar disorder had abnormal (too low or too high) number of platelets. Negative correlation between PLT and age was found in all study groups and positive correlation between age and MPV and P-LCR was found in patients with schizophrenia.
authors.affiliation: Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland. Electronic address: adam.wysokinski@umed.lodz.pl.
authors.forename: Adam
authors.initials: A
authors.lastname: Wysokiński
authors.affiliation: Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Szczepocka
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods; D008875:Middle Aged; D010976:Platelet Count / Q000379:methods; D012189:Retrospective Studies; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis; D055815:Young Adult
keywords: Bipolar disorder; Depression; MPV; P-LCR; PLT; Platelets; Schizophrenia