title: Marriage and fertility in long-term survivors of childhood, adolescent and young adult (AYA) high-grade sarcoma.
abstract: OBJECTIVE
  We investigated the marital status and the presence or absence of children in survivors of childhood, adolescent and young adult (AYA) high-grade sarcoma and examined the influence of these factors on the quality of life (QOL) of these survivors.
  
  
  METHODS
  Thirty-eight survivors of childhood and AYA high-grade sarcoma (18 males, 20 females) participated in a questionnaire survey on marital status and presence or absence of children, as well as on the health-related QOL (HR-QOL), using the Short Form 36 Health Survey. Diagnoses among these survivors were osteosarcoma (28 participants), Ewing's sarcoma (4 participants), synovial sarcoma (4 participants) and others (2 participants).
  
  
  RESULTS
  Of the 18 males who participated in the survey, eight (44.4 %) were married, of whom five (62.5 %) had children. Fifteen (75.0 %) of the 20 females were married, of whom 14 (93.3 %) had children. The proportions of surviving male patients who were married and who had children, respectively, were lower than those of surviving female patients. The proportion of ifosfamide-treated men with children was significantly lower than that of non-ifosfamide-treated men (p = 0.018). With respect to the relationship between marital status and HR-QOL, the scores for the vitality and mental health domains of the SF-36 of survivors who were married were significantly higher than those of unmarried survivors.
  
  
  CONCLUSIONS
  The results of our questionnaire survey reveal that among the male survivors of high-grade sarcoma, the proportions of those who were married and of those with children were lower than those of female survivors, suggesting that strategies providing support for marriage and child-rearing may be necessary for the male survivor group. In the married group, mental QOL was high.
authors.affiliation: Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, Chiba, 260-8717, Japan. tyonemot@chiba-cc.jp.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Yonemoto
authors.affiliation: Cancer Survivorship Research Division, Center for Cancer Control and Information Services, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Faculty of Nursing and Rehabilitation, Konan Women's University, 6-2-23 Morikita-machi, Higashinada-ku, Kobe City, Hyōgo, 658-0001, Japan.
authors.forename: Mitsue
authors.initials: M
authors.lastname: Maru
authors.affiliation: Department of Pediatric Nursing, Tokyo Healthcare University, 4-1-17 Higashi-gotanda, Shinagawa-ku, Tokyo, 141-8648, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Tomioka
authors.affiliation: Oizumi Gakuen Child and Adolescence Clinic, 6-47-18 Higashi-oizumi, Nerima-ku, Tokyo, 178-0063, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Saito
authors.affiliation: Tamagawa Health Care Center, NEC Corporation, 1753 Simonumabe, Nakahara-ku, Kawasaki, Kanagawa , 211-8666, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Araki
authors.affiliation: Cancer Survivorship Research Division, Center for Cancer Control and Information Services, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Tazaki
authors.affiliation: Cancer Survivorship Research Division, Center for Cancer Control and Information Services, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Tsuchiya
authors.affiliation: Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, Chiba, 260-8717, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Iwata
authors.affiliation: Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, Chiba, 260-8717, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kamoda
authors.affiliation: Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, Chiba, 260-8717, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishii
mesh_terms: D000293:Adolescent; D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000453:epidemiology*; D002648:Child; D005260:Female; D005298:Fertility / Q000187:drug effects; D006306:Health Surveys; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D017533:Marital Status / Q000706:statistics & numerical data*; D008393:Marriage / Q000706:statistics & numerical data; D008875:Middle Aged; D012516:Osteosarcoma / Q000188:drug therapy / Q000453:epidemiology; D011788:Quality of Life; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000453:epidemiology; D013584:Sarcoma, Synovial / Q000188:drug therapy / Q000453:epidemiology; D011795:Surveys and Questionnaires; D017741:Survivors / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide
keywords: Adolescent and young adult; Fertility; Marriage; Quality of life; Sarcoma