title: The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis.
abstract: BACKGROUND
  Osteoarthritis (OA) is one of the commonest forms of musculoskeletal disorders that leads to joint degeneration and has a major impact on patients' quality of life. Experimental and in vitro studies have suggested the protective roles of pomegranate juice (PJ) as a rich antioxidant source for mitigating cartilage inflammation. In this interventional study, 38 patients with knee OA were randomly divided into two groups: PJ or control for 6 weeks to evaluate the effect of this intervention on clinical signs, inflammation and antioxidant status.
  
  
  RESULTS
  Significant decreases in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) total score (P = 0.01), stiffness score (P = 0.00) and physical function score (P = 0.01) were observed in PJ group after the intervention. The means of serum levels of matrix metalloproteinase (MMP)-13 was significantly decreased (P = 0.02) and glutathione peroxidase was increased in the intervention group compared with the control group after the study period (P = 0.02).
  
  
  CONCLUSIONS
  According to the findings of this clinical trial, PJ consumption can improve physical function and stiffness, decrease breakdown cartilage enzymes and increase antioxidant status in patients with knee OA. © 2016 Society of Chemical Industry.
authors.affiliation: Nutrition and Metabolic Diseases Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Ghoochani
authors.affiliation: Nutrition and Metabolic Diseases Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Karandish
authors.affiliation: Department of Internal Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Karim
authors.initials: K
authors.lastname: Mowla
authors.affiliation: Department of Biostatics and Epidemiology, Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Haghighizadeh
authors.affiliation: Hyperlipidemia Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Mohammad Taha
authors.initials: MT
authors.lastname: Jalali
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D000067030:Fruit and Vegetable Juices / Q000032:analysis; D005979:Glutathione Peroxidase / Q000097:blood* / Q000737:chemistry; D006801:Humans; D007492:Iran; D007719:Knee Joint / Q000276:immunology / Q000503:physiopathology*; D029561:Lythraceae / Q000737:chemistry; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood / Q000737:chemistry; D053509:Matrix Metalloproteinase 13 / Q000097:blood* / Q000737:chemistry; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000178:diet therapy* / Q000276:immunology / Q000503:physiopathology; D018384:Oxidative Stress; D010147:Pain Measurement; D057566:Self Report; D012720:Severity of Illness Index
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D005979:Glutathione Peroxidase; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1
keywords: knee osteoarthritis; matrix metalloproteinases; pain; pomegranate