title: Sexual Function and Fertility of Women with Classic Bladder Exstrophy and Continent Urinary Diversion.
abstract: We evaluated the outcome in female patients with classic bladder exstrophy and continent urinary diversion for sexual function and fertility.
  
  
  
  We reviewed the medical records of female exstrophy patients who underwent continent urinary diversion in our department between 1969 and 2014. Patients were invited for followup examination and asked to complete questionnaires relating to sexual function, social integration and maternity.
  
  
  
  Of 38 eligible patients 29 (response rate 76%) with a followup of 22.3 years were included in study. Primary continent urinary diversion was done in 62% of patients and 38% underwent secondary continent urinary diversion after failed reconstruction of the exstrophic bladder. Sexual function as measured by the Female Sexual Function Index was only little affected in all domains except desire. Mean total Female Sexual Function Index score was 28.4 of a possible 36. Of the women 31% were classified as at risk for sexual dysfunction, 72% had a stable relationship, 41% were married and 31% had completed higher education. The incidence of pelvic organ prolapse requiring surgical repair was 38%. A total of 16 healthy children were conceived by 12 patients. The pregnancy rate after primary continent urinary diversion was higher than after secondary diversion.
  
  
  
  The sexuality and fertility of female patients with exstrophy after continent urinary diversion appears to be comparable with those in previously reported series of patients in whom the bladder was preserved. Management of sexual function, gynecologic pathologies and fertility should be an active part of long-term followup.
authors.affiliation: Division of Pediatric Urology, Mainz University Medical Center, Mainz, Germany. Electronic address: peterrubenwolf@gmx.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Rubenwolf
authors.affiliation: Department of Urology, Mainz University Medical Center, Mainz, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Thomas
authors.affiliation: Department of Urology, Mainz University Medical Center, Mainz, Germany.
authors.forename: Joachim W
authors.initials: JW
authors.lastname: Thüroff
authors.affiliation: Division of Pediatric Urology, Mainz University Medical Center, Mainz, Germany; Department of Pediatric and Adolescent Urology, Mannheim University Medical Center, Mannheim, Germany.
authors.forename: Raimund
authors.initials: R
authors.lastname: Stein
mesh_terms: D000328:Adult; D001746:Bladder Exstrophy / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000453:epidemiology / Q000209:etiology; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D012735:Sexual Dysfunction, Physiological / Q000453:epidemiology / Q000209:etiology*; D016896:Treatment Outcome; D014547:Urinary Diversion / Q000379:methods; D016476:Urinary Reservoirs, Continent
keywords: bladder exstrophy; fertility; pelvic organ prolapse; sexuality; urinary diversion