title: Long-Term Effects of In Utero Antiretroviral Exposure: Systolic and Diastolic Function in HIV-Exposed Uninfected Youth.
abstract: The aim of this study was to evaluate the association of in utero exposure to highly active antiretroviral therapy (HAART) with left ventricular (LV) function and structure in HIV-exposed uninfected (HEU) children. A prospective, multisite cohort study in HEU children was conducted by the Pediatric HIV/AIDS Cohort Study (PHACS). Echocardiographic measures of LV systolic and diastolic function and cardiac structure were obtained from HEU subjects aged ≥6 years enrolled in the PHACS Surveillance Monitoring of ART Toxicities study. Echocardiographic Z-scores were calculated using normative data from an established reference cohort. We used adjusted linear regression models to compare Z-scores for echocardiographic measures from HEU children exposed in utero to HAART with those exposed to non-HAART, adjusting for demographic and maternal health characteristics. One hundred seventy-four HEU subjects with echocardiograms and maternal ARV information were included (mean age 10.9 years; 48% male, 56% black non-Hispanic). Among 156 HEU youth with any ARV exposure, we observed no differences in Z-scores for LV systolic function measures between youth exposed in utero to HAART (39%) and HAART-unexposed youth in either unadjusted or adjusted models. In adjusted models, those exposed to HAART had significantly lower mitral late diastolic inflow velocities (adjusted mean Z-score = 0.00 vs. 0.52, p = .04) and significantly higher adjusted mean LV mass-to-volume ratio Z-scores (adjusted mean Z-score = 0.47 vs. 0.11, p = .03) than HAART-unexposed youth. Uninfected children with perinatal exposure to HAART had no difference in LV systolic function. However, small but significant differences in LV diastolic function and cardiac structure were observed, suggesting that continued monitoring for cardiac outcomes is warranted in this population.
authors.affiliation: 1 Department of Pediatrics, Tulane University School of Medicine , New Orleans, Louisiana.
authors.forename: Vitor
authors.initials: V
authors.lastname: Guerra
authors.affiliation: 2 Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health , Boston, Massachusetts.
authors.forename: Erin C
authors.initials: EC
authors.lastname: Leister
authors.affiliation: 2 Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health , Boston, Massachusetts.
authors.forename: Paige L
authors.initials: PL
authors.lastname: Williams
authors.affiliation: 3 Columbia University Medical Center , New York, New York.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Starc
authors.affiliation: 4 Wayne State University School of Medicine and Children's Hospital of Michigan , Detroit, Michigan.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lipshultz
authors.affiliation: 4 Wayne State University School of Medicine and Children's Hospital of Michigan , Detroit, Michigan.
authors.forename: James D
authors.initials: JD
authors.lastname: Wilkinson
authors.affiliation: 1 Department of Pediatrics, Tulane University School of Medicine , New Orleans, Louisiana.
authors.forename: Russell B
authors.initials: RB
authors.lastname: Van Dyke
authors.affiliation: 5 Eunice Kennedy Shriver National Institute of Child Health and Human Development , Bethesda, Maryland.
authors.forename: Rohan
authors.initials: R
authors.lastname: Hazra
authors.affiliation: 6 Harvard Medical School and Boston Children's Hospital , Boston, Massachusetts.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Colan
mesh_terms: D000293:Adolescent; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D002648:Child; D004452:Echocardiography; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000187:drug effects*; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011446:Prospective Studies; D013995:Time; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D044966:Anti-Retroviral Agents