title: Tyrphostin AG 1296 induces glioblastoma cell apoptosisin vitroandin vivo.
abstract: Glioblastoma is the most common type of malignant human brain tumor. Currently available chemotherapies for glioblastoma focus on targeting tyrosine kinases. However, the existing inhibitors of tyrosine kinases have not produced the therapeutic outcomes that were anticipated. In order to investigate the viability alternative chemotherapeutic agents in this disease, the present study examined the anticancer effects of tyrphostin AG 1296, focusing on its involvement in apoptosis in glioblastoma cells. The study aimed to identify whether tyrphostin AG 1296 affects glioblastoma cell growth by inducing cell apoptosis. To achieve this, cell viability, propidium iodide analysis and cell invasion assay were used to measure cell growth, cell apoptosis and cell migration of human glioblastoma cells. The results showed that tyrphostin AG 1296 treatment reduced cell viability and suppressed migration of human glioblastoma cells. It was also demonstrated that tyrphostin AG 1296 induced cell apoptosisin vitro. Finally, tyrphostin AG 1296 was also shown to significantly inhibit the growth of glioblastoma cells and to increase tumor cell apoptosisin vivo. These findings suggest that tyrphostin AG 1296 induces apoptosis, thereby reducing cell viability and capacity for migration of glioblastoma cells.
authors.affiliation: Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China; Department of Neurosurgery, The Eight People's Hospital of Shenzhen, Shenzhen, Guangdong 510000, P.R. China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The Eight People's Hospital of Shenzhen, Shenzhen, Guangdong 510000, P.R. China.
authors.forename: Junning
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Neurosurgery, The Eight People's Hospital of Shenzhen, Shenzhen, Guangdong 510000, P.R. China.
authors.forename: Ruiyun
authors.initials: R
authors.lastname: Guan
authors.affiliation: Department of Neurosurgery, The Eight People's Hospital of Shenzhen, Shenzhen, Guangdong 510000, P.R. China.
authors.forename: Zifeng
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China.
authors.forename: Xianhou
authors.initials: X
authors.lastname: Yuan
keywords: cancer therapy; glioblastoma; platelet-derived growth factor receptor inhibitor; tyrphostin AG 1296