title: Becoming a crossover-competent DSB.
abstract: The proper execution of meiotic recombination (or crossing over) is essential for chromosome segregation during the first meiotic division, and thus this process is regulated by multiple, and often elaborate, mechanisms. Meiotic recombination begins with the programmed induction of DNA double-strand breaks (DSBs), of which only a subset are selected to be repaired into crossovers. This crossover selection process is carried out by a number of pro-crossover proteins that regulate the fashion in which DSBs are repaired. Here, we highlight recent studies regarding the process of DSB fate selection by a family of pro-crossover proteins known as the Zip-3 homologs.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
authors.forename: Cathleen M
authors.initials: CM
authors.lastname: Lake
authors.affiliation: Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Molecular and Integrative Physiology, Kansas University Medical Center, Kansas City, KS 66160, USA. Electronic address: RSH@stowers.org.
authors.forename: R Scott
authors.initials: RS
authors.lastname: Hawley
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003434:Crossing Over, Genetic; D053903:DNA Breaks, Double-Stranded; D006801:Humans; D008540:Meiosis / Q000235:genetics
keywords: Crossover; Double-strand break; Meiosis; Sumoylation; Ubiquitination