title: Stimulus-induced visual cortical networks are recapitulated by spontaneous local and interareal synchronization.
abstract: Intrinsic covariation of brain activity has been studied across many levels of brain organization. Between visual areas, neuronal activity covaries primarily among portions with similar retinotopic selectivity. We hypothesized that spontaneous interareal coactivation is subserved by neuronal synchronization. We performed simultaneous high-density electrocorticographic recordings across the dorsal aspect of several visual areas in one hemisphere in each of two awake monkeys to investigate spatial patterns of local and interareal synchronization. We show that stimulation-induced patterns of interareal coactivation were reactivated in the absence of stimulation for the visual quadrant covered. Reactivation occurred through both interareal cofluctuation of local activity and interareal phase synchronization. Furthermore, the trial-by-trial covariance of the induced responses recapitulated the pattern of interareal coupling observed during stimulation, i.e., the signal correlation. Reactivation-related synchronization showed distinct peaks in the theta, alpha, and gamma frequency bands. During passive states, this rhythmic reactivation was augmented by specific patterns of arrhythmic correspondence. These results suggest that networks of intrinsic covariation observed at multiple levels and with several recording techniques are related to synchronization and that behavioral state may affect the structure of intrinsic dynamics.
authors.affiliation: Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN, Nijmegen, The Netherlands; chris.lewis@esi-frankfurt.de.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Lewis
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN, Nijmegen, The Netherlands; Cognitive and Systems Neuroscience Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 XH, Amsterdam, The Netherlands.
authors.forename: Conrado A
authors.identifier: http://orcid.org/0000-0003-2433-6126
authors.initials: CA
authors.lastname: Bosman
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN, Nijmegen, The Netherlands;
authors.forename: Thilo
authors.identifier: http://orcid.org/0000-0001-6921-4187
authors.initials: T
authors.lastname: Womelsdorf
authors.affiliation: Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN, Nijmegen, The Netherlands;
authors.forename: Pascal
authors.initials: P
authors.lastname: Fries
mesh_terms: D000818:Animals; D004569:Electroencephalography; D000882:Haplorhini; D014793:Visual Cortex / Q000502:physiology*
keywords: connectivity; intrinsic activity; networks; oscillations; vision