title: [Negative symptoms of schizophrenia: historical aspects].
abstract: The history of negative symptoms of schizophrenia rises early days of medicine in clinical and pathophysiological differences between positive and negative and their complex joint. Forming a set of typical core of symptoms, and some feature of a syndrome belonging to a specific pathophysiological mechanism, negative symptoms of schizophrenia emerge from old descriptions of clinical pictures, related to the overall look of madness, the heart of alienation, a central sign of early dementia, gradually more precisely describing the strange nature of the autistic withdrawal and schizophrenic apragmatism. At therapeutic era, negative symptoms have taken over the positive symptoms to establish an operational criteria whose importance lies in the progressive severity of this clinical type and in their contribution to therapeutic resistance. Despite the efforts of modern typological classifications, this work rehabilitates the old concept of "unitary psychosis" by defining a common symptomatic core to multiple clinical forms of psychosis, combining deficit of emotional expression and avolition, meaning a native psychopathology and a pathophysiology possibly in a common final way, and calling the arrival of new treatment strategies.
authors.affiliation: Faculté de Médecine de Nice - UNSA - 28 Av Valombrose, 06107 Nice, France. Electronic address: pringuey@unice.fr.
authors.forename: D
authors.initials: D
authors.lastname: Pringuey
authors.affiliation: Faculté de Médecine de Nice - UNSA - 28 Av Valombrose, 06107 Nice, France.
authors.forename: N
authors.initials: N
authors.lastname: Paquin
authors.affiliation: Faculté de Médecine de Nice - UNSA - 28 Av Valombrose, 06107 Nice, France.
authors.forename: F
authors.initials: F
authors.lastname: Cherikh
authors.affiliation: Faculté de Médecine de Nice - UNSA - 28 Av Valombrose, 06107 Nice, France.
authors.forename: B
authors.initials: B
authors.lastname: Giordana
authors.affiliation: SHU Psychiatrie adultes, Hôpital Ste Marguerite, 13274 Marseille cedex 9, France.
authors.forename: R
authors.initials: R
authors.lastname: Belzeaux
authors.affiliation: SHU Psychiatrie adultes, Hôpital Ste Marguerite, 13274 Marseille cedex 9, France.
authors.forename: M
authors.initials: M
authors.lastname: Cermolacce
authors.affiliation: SHU Psychiatrie adultes, Hôpital Ste Marguerite, 13274 Marseille cedex 9, France.
authors.forename: M
authors.initials: M
authors.lastname: Adida
authors.affiliation: SHU Psychiatrie adultes, Hôpital Ste Marguerite, 13274 Marseille cedex 9, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Azorin
mesh_terms: D004739:England; D005602:France; D005858:Germany; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D011570:Psychiatry / Q000266:history*; D012559:Schizophrenia / Q000628:therapy*; D012565:Schizophrenic Psychology
keywords: Classifications psychiatriques; Diagnostic evaluation; Histoire de la psychiatrie; History of psychiatry; Negative symptoms; Psychiatric classifications; Psychose unique; Schizophrenia; Schizophrénie; Symptômes négatifs; Unitary psychosis; Évaluations diagnostiques