title: Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery.
abstract: We describe, for the first time, stimulus-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 h). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in "on-demand" delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.
authors.affiliation: School of Pharmacy, Queens University Belfast, Medical Biology Centre , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland U.K.
authors.forename: John G
authors.initials: JG
authors.lastname: Hardy
authors.affiliation: School of Pharmacy, Queens University Belfast, Medical Biology Centre , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland U.K.
authors.forename: Eneko
authors.initials: E
authors.lastname: Larrañeta
authors.affiliation: School of Pharmacy, Queens University Belfast, Medical Biology Centre , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland U.K.
authors.forename: Ryan F
authors.initials: RF
authors.lastname: Donnelly
authors.affiliation: School of Pharmacy, Queens University Belfast, Medical Biology Centre , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland U.K.
authors.forename: Niamh
authors.initials: N
authors.lastname: McGoldrick
authors.affiliation: School of Pharmacy, Queens University Belfast, Medical Biology Centre , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland U.K.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Migalska
authors.affiliation: School of Pharmacy, Queens University Belfast, Medical Biology Centre , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland U.K.
authors.forename: Maelíosa T C
authors.initials: MT
authors.lastname: McCrudden
authors.affiliation: School of Pharmacy, Queens University Belfast, Medical Biology Centre , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland U.K.
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Irwin
authors.affiliation: School of Pharmacy, Queens University Belfast, Medical Biology Centre , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland U.K.
authors.forename: Louise
authors.initials: L
authors.lastname: Donnelly
authors.affiliation: School of Pharmacy, Queens University Belfast, Medical Biology Centre , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland U.K.
authors.forename: Colin P
authors.initials: CP
authors.lastname: McCoy
mesh_terms: D000279:Administration, Cutaneous; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage / Q000378:metabolism*; D008027:Light; D008422:Materials Testing; D008845:Microinjections; D009339:Needles; D011108:Polymers / Q000737:chemistry*; D012867:Skin
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D020100:Hydrogels; D011108:Polymers; D007052:Ibuprofen
keywords: hydrogel; light-triggered; microneedle; stimuli-responsive