title: A longitudinally extensive myelopathy associated with multiple spinal arteriovenous fistulas in a patient with Cowden syndrome: a case report.
abstract: Cowden syndrome is an autosomal dominant syndrome characterized by multiple hamartomas and an increased cancer risk. It is associated with mutations in the phosphatase and tensin homologue (PTEN) gene that encodes a tumor suppressant phosphatase.
  
  
  
  The study aimed to report an unusual case of multiple spinal epidural arteriovenous fistulas in a patient diagnosed with Cowden syndrome.
  
  
  
  This is a case report.
  
  
  
  The patient is a 57-year-old woman.
  
  
  
  We report the case of a 57-year-old woman with a history of multiple cancers, with acute exacerbation of lower extremity weakness and numbness that had progressed over a month.
  
  
  
  Magnetic resonance imaging showed abnormal signal in the thoracolumbar spinal cord, with enhancement after contrast administration. A spinal angiogram confirmed the presence of multiple spinal epidural arteriovenous fistulas. Genetic testing confirmed the diagnosis of Cowden syndrome with a mutation in intron 3 of the PTEN gene.
  
  
  
  Spinal vascular malformations occur in patients with Cowden syndrome, and they can be multifocal and locally aggressive. It is important to raise the suspicion of Cowden syndrome in patients with spinal cord vascular anomalies and a history of multiple cancers, as the correct genetic diagnosis may have implications for management and cancer screening.
authors.affiliation: Department of Neurology & Division of Neuroimmunology and Neuroinfectious Disorders, Johns Hopkins University School of Medicine, 600 North Wolfe St, 627 Pathology Blvd, Baltimore, MD 21287, USA; Johns Hopkins Transverse Myelitis Center, Johns Hopkins University School of Medicine, 600 North Wolfe St, 627 Pathology Blvd, Baltimore, MD 21287, USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Barreras
authors.affiliation: Department of Radiology & Division of Interventional Neuroradiology, Johns Hopkins University School of Medicine, 1800 E Orleans Street, Bloomberg 7218, Baltimore, MD 21287, USA.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gailloud
authors.affiliation: Department of Neurology & Division of Neuroimmunology and Neuroinfectious Disorders, Johns Hopkins University School of Medicine, 600 North Wolfe St, 627 Pathology Blvd, Baltimore, MD 21287, USA; Johns Hopkins Transverse Myelitis Center, Johns Hopkins University School of Medicine, 600 North Wolfe St, 627 Pathology Blvd, Baltimore, MD 21287, USA. Electronic address: cpardov1@jhmi.edu.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Pardo
mesh_terms: D000792:Angiography; D001164:Arteriovenous Fistula / Q000150:complications*; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D051059:PTEN Phosphohydrolase / Q000235:genetics
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: Arteriovenous fistula; Cancer; Cowden syndrome; Myelopathy; PTEN; Paraparesis; Spinal cord