title: Adeno-associated virus (AAV) vectors in cancer gene therapy.
abstract: Gene delivery vectors based on adeno-associated virus (AAV) have been utilized in a large number of gene therapy clinical trials, which have demonstrated their strong safety profile and increasingly their therapeutic efficacy for treating monogenic diseases. For cancer applications, AAV vectors have been harnessed for delivery of an extensive repertoire of transgenes to preclinical models and, more recently, clinical trials involving certain cancers. This review describes the applications of AAV vectors to cancer models and presents developments in vector engineering and payload design aimed at tailoring AAV vectors for transduction and treatment of cancer cells. We also discuss the current status of AAV clinical development in oncology and future directions for AAV in this field.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Santiago-Ortiz
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA; Department of Bioengineering, University of California, Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; The Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA. Electronic address: schaffer@berkeley.edu.
authors.forename: David V
authors.initials: DV
authors.lastname: Schaffer
mesh_terms: D036022:Capsid Proteins / Q000235:genetics; D002986:Clinical Trials as Topic; D000229:Dependovirus / Q000235:genetics*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D015202:Protein Engineering; D019076:Transgenes
chemical_list: D036022:Capsid Proteins
keywords: AAV; Adeno-associated virus; Cancer; Gene delivery; Gene delivery vectors; Gene therapy