title: HCV in 2015: Advances in hepatitis C research and treatment.
abstract: In 2015, new treatment regimens were revealed that achieve >95% cure rates for all HCV genotypes. The HCV polymerase structure was solved in catalytically relevant HCV replication steps and in the context of nucleotide analogue inhibition. Moreover, HCV research taught us new links between innate antiviral responses, lipid metabolism and intracellular membrane formation.
authors.affiliation: Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, 10 Center Drive, Bethesda, Maryland 20892, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Rehermann
mesh_terms: D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D012106:Research