title: Four types of cannabimimetic indazole and indole derivatives, ADB-BINACA, AB-FUBICA, ADB-FUBICA, and AB-BICA, identified as new psychoactive substances.
abstract: We identified four cannabimimetic indazole and indole derivatives in new illegal psychoactive substances seized from a clandestine laboratory in China. These four derivatives includedN-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-benzyl-1H-indazole-3-carboxamide (ADB-BINACA,1),N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (AB-FUBICA,2),N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (ADB-FUBICA,3), andN-(1-amino-3-methyl-1-oxobutan-2-yl)-1-benzyl-1H-indole-3-carboxamide (AB-BICA,4). These compounds were identified by liquid chromatography-high-resolution mass spectrometry, gas chromatography-mass spectrometry, and nuclear magnetic resonance spectroscopy. No chemical or pharmacological data about compound4has appeared until now, making this the first report on this compound. Compounds1,2, and3have previously been reported to have a high affinity for cannabinoid CB1and CB2receptors, but this is the first report of their presence in illegal products.
authors.affiliation: National Narcotic Laboratory, Drug Intelligence and Forensic Center of Minister of Public Security, No. 18 Dongbeiwang West Round, Haidian District, Beijing, 100193 China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Qian
authors.affiliation: National Narcotic Laboratory, Drug Intelligence and Forensic Center of Minister of Public Security, No. 18 Dongbeiwang West Round, Haidian District, Beijing, 100193 China.
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Hua
authors.affiliation: National Narcotic Laboratory, Drug Intelligence and Forensic Center of Minister of Public Security, No. 18 Dongbeiwang West Round, Haidian District, Beijing, 100193 China.
authors.forename: Cuimei
authors.initials: C
authors.lastname: Liu
authors.affiliation: National Narcotic Laboratory, Drug Intelligence and Forensic Center of Minister of Public Security, No. 18 Dongbeiwang West Round, Haidian District, Beijing, 100193 China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
keywords: N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (ADB-FUBICA); N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-benzyl-1H-indazole-3-carboxamide (ADB-BINACA); N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (AB-FUBICA); N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-benzyl-1H-indole-3-carboxamide (AB-BICA); New psychoactive substance; Synthetic cannabinoid