title: Assessment of the prophylactic speed of kill of Frontline Tri-Act(®) against ticks (Ixodes ricinus and Rhipicephalus sanguineus) on dogs.
abstract: The objective of the study was to assess the speed of kill of a single topical treatment with a combination of fipronil and permethrin (Frontline Tri-Act(®)/Frontect(®)) against experimental infestations of Ixodes ricinus and Rhipicephalus sanguineus ticks on dogs. In this parallel group designed, randomised, single centre, controlled efficacy study, 16 healthy adult dogs were allocated to two groups: 8 dogs were treated with the topical combination on Day 0 and the other 8 dogs served as untreated controls. Each dog was exposed in a crate to 100 I. ricinus (50 females, 50 males) and 50 R. sanguineus (25 males, 25 females) on Days 2, 7, 14, 21 and 28. Ticks were counted in situ at 6 and 12 h after exposure and removed at 24 h after exposure. Frontline Tri-Act(®) was effective (≥90%) against both R. sanguineus and I. ricinus tick infestations at 6, 12 and 24 h after exposure, from 2 to 28 days after treatment. This is the first time that a topical ectoparasiticide has demonstrated a preventive killing effect against these two tick species in 6 h for a full month.
authors.affiliation: Merial SAS, 29 Avenue Tony Garnier, 69007 Lyon, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Beugnet
authors.affiliation: Merial SAS, 29 Avenue Tony Garnier, 69007 Lyon, France.
authors.forename: Lénaïg
authors.initials: L
authors.lastname: Halos
authors.affiliation: ClinVet International (Pty) Ltd, PO Box 11186, 9321 Universitas, South Africa.
authors.forename: Julian
authors.initials: J
authors.lastname: Liebenberg
authors.affiliation: ClinVet International (Pty) Ltd, PO Box 11186, 9321 Universitas, South Africa.
authors.forename: Josephus
authors.initials: J
authors.lastname: Fourie
mesh_terms: D056810:Acaricides / Q000494:pharmacology* / Q000627:therapeutic use; D000287:Administration, Topical; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D018884:Ixodes / Q000187:drug effects*; D008297:Male; D026023:Permethrin / Q000494:pharmacology* / Q000627:therapeutic use; D011720:Pyrazoles / Q000494:pharmacology* / Q000627:therapeutic use; D048508:Rhipicephalus sanguineus / Q000187:drug effects*; D013984:Tick Infestations / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D013997:Time Factors
chemical_list: D056810:Acaricides; D004338:Drug Combinations; D011720:Pyrazoles; D026023:Permethrin; C082360:fipronil