title: [A Case of Granulocyte-Colony Stimulating Factor-Producing Gastric Cancer Successfully Treated with Trastuzumab].
abstract: A 68-year-old man diagnosed with type 0-Ⅰgastric cancer by gastrointestinal endoscopy underwent urgent distal gastrectomy due to a perforation during endoscopic submucosal resection. Pathological examination revealed pT3N2M0, pStage ⅢA. TS-1 was administered as adjuvant chemotherapy. Laboratory examinations 10 months after surgery revealed leukocytosis (19,100/mL). Positron emission tomography-CT demonstrated metastases in the bone marrow and ascending colon as well as around the liver. Chemotherapy using nab-PTX had poor efficacy and the leukocytosis worsened. Serum granulocyte- colony stimulating facto (r G-CSF) was high at 1,640 pg/mL, and immunohistochemical staining was positive for G-CSF. Thus, the patient was diagnosed with G-CSF-producing gastric cancer. The tumor was also positive for HER2 antibody by immunohistochemical staining. Combination therapy using TS-1 plus CDDP plus trastuzumab resulted in a good response, and the leukocytosis and elevated serum G-CSF gradually improved. The patient is living 30 months postoperatively and remains on chemotherapy.
authors.affiliation: Dept. of Surgery, Kansai Rousai Hospital.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Matsushita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeno
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tamura
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Tomo
authors.initials: T
authors.lastname: Ishida
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Sato
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kusama
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Kei
authors.initials: K
authors.lastname: Kimura
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Katsura
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ohmura
authors.forename: Kanae
authors.initials: K
authors.lastname: Nitta
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kagawa
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Okisiro
authors.forename: Hideki
authors.initials: H
authors.lastname: Sakisaka
authors.forename: Chiyomi
authors.initials: C
authors.lastname: Egawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takeda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kato
mesh_terms: D000368:Aged; D005743:Gastrectomy; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D000068878:Trastuzumab / Q000627:therapeutic use*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D000068878:Trastuzumab