title: The clinicopathological significance of FHIT hypermethylation in non-small cell lung cancer, a meta-analysis and literature review.
abstract: Emerging evidence indicates that FHIT is a candidate tumor suppressor in non-small cell lung cancer (NSCLC). However, the correlation between FHIT hypermethylation and clinicopathological characteristics of NSCLC remains unclear. Thus, we conducted a meta-analysis to quantitatively evaluate the effects of FHIT hypermethylation on the incidence of NSCLC and clinicopathological characteristics. Final analysis of 1717 NSCLC patients from 16 eligible studies was performed. FHIT hypermethylation was found to be significantly higher in NSCLC than in normal lung tissue, the pooled OR from 8 studies including 735 NSCLC and 708 normal lung tissue, OR = 5.45, 95% CI = 2.15-13.79, p = 0.0003. FHIT hypermethylation was also correlated with sex status, smoking status, as well as pathological types. We did not find that FHIT hypermethylation was correlated with the differentiated types or clinical stages in NSCLC patients. However, patients with FHIT hypermethylation had a lower survival rate than those without, HR = 1.73, 95% CI = 1.10-2.71, p = 0.02. The results of this meta-analysis suggest that FHIT hypermethylation is associated with an increased risk and worsen survival in NSCLC patients. FHIT hypermethylation, which induces the inactivation of FHIT gene, plays an important role in the carcinogenesis and clinical outcome and may serve as a potential drug target of NSCLC.
authors.affiliation: Department of Respiratory Medicine, Peking University Third Hospital, Beijing, 100191, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Rheumatology, Peking University Third Hospital, Beijing, 100191, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Xu
authors.affiliation: Department of Respiratory Medicine, Peking University Third Hospital, Beijing, 100191, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Respiratory Medicine, The Shengjing Hospital of China Medical University, Shenyang, 110004, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, Peking University Third Hospital, Beijing, 100191, China.
authors.forename: Bei
authors.initials: B
authors.lastname: He
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology*; D019175:DNA Methylation / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D016017:Odds Ratio; D017594:Publication Bias; D012907:Smoking / Q000009:adverse effects; D016019:Survival Analysis; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase