title: Au-Catalysed oxidative cyclisation.
abstract: The two main strategies of gold-catalysed oxidative cyclisation are discussed in this tutorial. The first one employs nucleophilic oxidants as either internal or external nucleophiles. The inherently weak O-heteroatom bond in the oxidant enables the versatile reactivities of the initial gold-promoted adduct of the oxidant to alkyne, including its fragmentation into a highly reactive α-oxo gold carbene intermediate. The second features external oxidant-powered Au(i)/Au(iii) catalysis, where the metal oxidation state changes during the catalytic cycle. These strategies have been applied toward the development of a variety of valuable synthetic transformations.
authors.affiliation: Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA. zhang@chem.ucsb.edu.
authors.forename: Zhitong
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA. zhang@chem.ucsb.edu.
authors.forename: Zhixun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA. zhang@chem.ucsb.edu.
authors.forename: Youliang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA. zhang@chem.ucsb.edu.
authors.forename: Liming
authors.initials: L
authors.lastname: Zhang