title: ANALYSIS OF THREE-DIMENSIONAL CHOROIDAL VOLUME WITH ENHANCED DEPTH IMAGING FINDINGS IN PATIENTS WITH BIRDSHOT RETINOCHOROIDOPATHY.
abstract: OBJECTIVE
  To describe changes in three-dimensional choroidal volume and thickness with full raster scans of enhanced depth imaging optical coherence tomography in patients with birdshot retinochoroidopathy.
  
  
  METHODS
  This prospective case series collected spectral domain optical coherence tomography images with the enhanced depth imaging technique from eight eyes of eight patients with birdshot retinochoroidopathy including four active patients (four eyes) and four quiet patients (four eyes). Fifty scans of each patient were manually segmented before automated built-in calibration software was used.
  
  
  RESULTS
  Of all active patients, there were no statistically significant differences in the total choroidal volume and mean central choroidal thickness between the active and inactive phase over 6 months of follow-up. Alterations in choroidal parameters were evident and consistent after amelioration of inflammation, whereas the retinal volume and thickness remained stable. Regarding the eight inactive eyes at 6 months, the mean total choroidal volume and mean central choroidal thickness were significantly less than historical controls (P = 0.03 and P < 0.001, respectively). Persistent suprachoroidal hyporeflective space in two patients was noted despite the fact that clinical inflammation completely subsided at 6 months.
  
  
  CONCLUSIONS
  Choroidal volume and thickness changes were consistent with inflammation in patients with birdshot retinochoroidopathy. Patients with inactive birdshot retinochoroidopathy have significant reduction in choroidal volume and thickness than do normal patients.
authors.affiliation: *Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; †Ocular Immunology & Uveitis Foundation, Waltham, Massachusetts; ‡Department of Ophthalmology, Faculty of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand; §Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran; and ¶Harvard Medical School, Boston, Massachusetts.
authors.forename: Sukhum
authors.initials: S
authors.lastname: Silpa-Archa
authors.forename: Arash
authors.initials: A
authors.lastname: Maleki
authors.forename: Ramak
authors.initials: R
authors.lastname: Roohipoor
authors.forename: Janine M
authors.initials: JM
authors.lastname: Preble
authors.forename: C Stephen
authors.initials: CS
authors.lastname: Foster
mesh_terms: D000328:Adult; D000080365:Birdshot Chorioretinopathy; D002825:Chorioretinitis / Q000000981:diagnostic imaging*; D002829:Choroid / Q000473:pathology*; D004396:Coloring Agents / Q000008:administration & dosage; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D021621:Imaging, Three-Dimensional; D007208:Indocyanine Green / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green