title: The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis.
abstract: Changes in chromatin structure and heritably regulating the gene expression by epigenetic mechanisms, such as histone post-translational modification, are involved in most cellular biological processes. Thus, abnormal regulation of epigenetics is implicated in the occurrence of various diseases, including cancer. Human MOF (males absent on the first) is a member of the MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of histone acetyltransferases (HATs). As a catalytic subunit, MOF can form at least two distinct multiprotein complexes (MSL and NSL) in human cells. Both complexes can acetylate histone H4 at lysine 16 (H4K16); however, the NSL complex possesses broader substrate specificity and can also acetylate histone H4 at lysines 5 and 8 (H4K5 and H4K8), suggesting the complexity of the intracellular functions of MOF. Silencing of MOF in cells leads to genomic instability, inactivation of gene transcription, defective DNA damage repair and early embryonic lethality. Unbalanced MOF expression and its corresponding acetylation of H4K16 have been found in certain primary cancer tissues, including breast cancer, medulloblastoma, ovarian cancer, renal cell carcinoma, colorectal carcinoma, gastric cancer, as well as non-small cell lung cancer. In this review, we provide a brief overview of MOF and its corresponding histone acetylation, introduce recent research findings that link MOF functions to tumorigenesis and speculate on the potential role that may be relevant to tumorigenic pathways.
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China. xiaosuyoc@gmail.com.
authors.forename: Jiaming
authors.initials: J
authors.lastname: Su
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China. fei@jlu.edu.cn.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China. caiyong62@jlu.edu.cn.|National Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun 130012, China. caiyong62@jlu.edu.cn.|Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun 130012, China. caiyong62@jlu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cai
authors.affiliation: School of Life Sciences, Jilin University, Changchun 130012, China. jjjin@jlu.edu.cn.|National Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun 130012, China. jjjin@jlu.edu.cn.|Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun 130012, China. jjjin@jlu.edu.cn.
authors.forename: Jingji
authors.initials: J
authors.lastname: Jin
mesh_terms: D000107:Acetylation; D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D051548:Histone Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D011499:Protein Processing, Post-Translational
chemical_list: D006657:Histones; D051548:Histone Acetyltransferases
keywords: H4K16ac; MOF; MYST; histone acetyltransferase; tumorigenesis