title: Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis.
abstract: Genetic polymorphisms (C677T and A1298C) in methylenetetrahydrofolate reductase (MTHFR) were shown to be related to prostate cancer risk in previous studies; however, the results are controversial. We performed a meta-analysis of previous studies and quantitatively estimated these associations. Pubmed, Embase, and Cochrane Library Database were searched for published case-control studies evaluating the association between C677T (or A1298C) and prostate cancer risk. Pooled associations were presented as odds ratios (ORs) along with their 95% confidence intervals. Twenty-one case control studies were identified for meta-analysis that included 21,581 participants. No significant associations were found between the MTHFR polymorphisms C677T or A1298C and prostate cancer risk in our meta-analysis. However, in subgroup analyses, the C677T CT polymorphism was associated with increased prostate cancer risk in East Asians (CT vs CC+TT: OR = 1.324, P = 0.03). The A1298C CC polymorphism in MTHFR was also linked to slightly reduced prostate cancer risk in European residents (CC vs AC+AA: OR = 0.751, P = 0.004; CC vs AA: OR = 0.768, P = 0.011), whereas it was associated with a significantly increased prostate cancer risk in Asian residents (CC vs AA: OR = 1.862, P = 0.006). The C677T CT polymorphism of MTHFR may be a risk factor for prostate cancer in East Asians. The association between the MTHFR A1298C CC genotype and prostate cancer risk may vary within different populations. Large-scale well-designed studies are required to confirm these associations.
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University, Guangdong Province, China.
authors.forename: P L
authors.initials: PL
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Southern Medical University.
authors.forename: W T
authors.initials: WT
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangdong Province, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University, Guangdong Province, China.
authors.forename: Y D
authors.initials: YD
authors.lastname: Jiang
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University, Guangdong Province, China.
authors.forename: P
authors.initials: P
authors.lastname: Wu
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University, Guangdong Province, China.
authors.forename: T
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University, Guangdong Province, China.
authors.forename: S B
authors.initials: SB
authors.lastname: Zheng
mesh_terms: D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D044465:White People
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)