title: Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.
abstract: Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.
authors.affiliation: Department of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wen
authors.affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 1628655, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kato
authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
authors.forename: Joo-Yeon
authors.initials: JY
authors.lastname: Hwang
authors.affiliation: Department of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
authors.forename: Xingyi
authors.initials: X
authors.lastname: Guo
authors.affiliation: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.|Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Huaixing
authors.initials: H
authors.lastname: Li
authors.affiliation: Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Dorajoo
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.|Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Yang
authors.affiliation: School of Chinese Medicine, China Medical University, Taichung, Taiwan.|Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan.|Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
authors.forename: Shengxu
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Tangchun
authors.initials: T
authors.lastname: Wu
authors.affiliation: Institute for Health Promotion, Yonsei University, Seodaemun-Gu, Seoul 120-749, Korea.
authors.forename: Soriul
authors.initials: S
authors.lastname: Kim
authors.affiliation: Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Endocrinology, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Clinical Sciences, Genetic &Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö 205 02, Sweden.|Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Shungin
authors.affiliation: Department of Medical Chemistry, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Linda S
authors.initials: LS
authors.lastname: Adair
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute &Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Koichi
authors.initials: K
authors.lastname: Akiyama
authors.affiliation: Division of Preventive Medicine, Department of Family and Preventive Medicine, University of California, San Diego School of Medicine, San Diego, California, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Allison
authors.affiliation: Department of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
authors.forename: Qiuyin
authors.initials: Q
authors.lastname: Cai
authors.affiliation: National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Chang
authors.affiliation: National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.|School of Chinese Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Chien-Hsiun
authors.initials: CH
authors.lastname: Chen
authors.affiliation: National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Yuan-Tsong
authors.initials: YT
authors.lastname: Chen
authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.|Department of Biomedical Science, Hallym University, Gangwon-do, Korea.
authors.forename: Yoon Shin
authors.initials: YS
authors.lastname: Cho
authors.affiliation: Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Bo Youl
authors.initials: BY
authors.lastname: Choi
authors.affiliation: Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Yutang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
authors.forename: Min Jin
authors.initials: MJ
authors.lastname: Go
authors.affiliation: Division of Population Genetics, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
authors.forename: Bok-Ghee
authors.initials: BG
authors.lastname: Han
authors.affiliation: Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Meian
authors.initials: M
authors.lastname: He
authors.affiliation: Human Genetics Center, University of Texas School of Public Health, Houston, Texas, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Hixson
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.|Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 1628655, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Isono
authors.affiliation: Institute for Health Promotion, Yonsei University, Seodaemun-Gu, Seoul 120-749, Korea.
authors.forename: Keum Ji
authors.initials: KJ
authors.lastname: Jung
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Daehee
authors.initials: D
authors.lastname: Kang
authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Nursing, Tsuruga University of Nursing, Tsuruga, Japan.
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Kita
authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
authors.forename: Juyoung
authors.initials: J
authors.lastname: Lee
authors.affiliation: Office of Population Studies Foundation Inc., University of San Carlos, Talamban, Cebu City, Philippines.
authors.forename: Nanette R
authors.initials: NR
authors.lastname: Lee
authors.affiliation: Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
authors.forename: Jeannette
authors.initials: J
authors.lastname: Lee
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Yiqin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Saw Swee Hock School of Public Health, National University of Singapore, Singapore.|Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
authors.forename: Jirong
authors.initials: J
authors.lastname: Long
authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Moon
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Shiga, Japan.|Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Showa-ku, Nagoya 466-8560, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakatochi
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Keizo
authors.initials: K
authors.lastname: Ohnaka
authors.affiliation: Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Dabeeru
authors.initials: D
authors.lastname: Rao
authors.affiliation: Department of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Shi
authors.affiliation: Eulji University, Seongnam City, Gyeonggi-do, Korea.
authors.forename: Jae Woong
authors.initials: JW
authors.lastname: Sull
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.|Department of Chemotherapy, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Tan
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Shiga, Japan.|Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute &Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wu
authors.affiliation: Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.affiliation: Department of Medical Chemistry, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Yao
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Xingwang
authors.initials: X
authors.lastname: Ye
authors.affiliation: Department of Genome Science, Aichi-Gakuin University, School of Dentistry, Chikusa-ku, Nagoya, 464-8651, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Yokota
authors.affiliation: Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.affiliation: Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.affiliation: Institute for Health Promotion, Yonsei University, Seodaemun-Gu, Seoul 120-749, Korea.
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Jee
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute &Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Dongxin
authors.initials: D
authors.lastname: Lin
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Mohlke
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: He
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.|Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Zengnan
authors.initials: Z
authors.lastname: Mo
authors.affiliation: National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.|School of Chinese Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Jer-Yuarn
authors.initials: JY
authors.lastname: Wu
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.|Saw Swee Hock School of Public Health, National University of Singapore, Singapore.|Duke-National University of Singapore Graduate Medical School, Singapore.
authors.forename: E Shyong
authors.initials: ES
authors.lastname: Tai
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Lin
authors.affiliation: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.|Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
authors.forename: Bong-Jo
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 1628655, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Takeuchi
authors.affiliation: Department of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
mesh_terms: D001208:Asia; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D012737:Sex Factors; D055105:Waist Circumference; D049629:Waist-Hip Ratio