title: The tumor suppressor role of miR-4782-3p in hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortalities in China. Although advances have been made in treatments, the prognosis of HCC patients has not improved significantly. MicroRNAs (miRNA) play important roles in all stage of the progress of HCC. miR-4782-3p takes part in the pathogenesis of non-small cell lung cancer (NSCLC). However, the role of miR-4782-3p in HCC remains unknown. In the present study, we found that miR-4782-3p had low expression in HCC tissues. The low expression of miR-4782-3p indicated shorter survival of HCC patients. Moreover, the low expression of miR-4782-3p promoted HCC cells growth and inhibited cell apoptosis. We confirmed that USP14 was targeted by miR-4782-3p in HCC cells.
authors.affiliation: Department of Hepatobiliary and Gastrointestinal Surgery, Sichuan Provincial Cancer Hospital, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Bo
authors.affiliation: Department of Hepatobiliary and Gastrointestinal Surgery, Sichuan Provincial Cancer Hospital, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Hepatobiliary and Gastrointestinal Surgery, Sichuan Provincial Cancer Hospital, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Xielin
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Hepatobiliary and Gastrointestinal Surgery, Sichuan Provincial Cancer Hospital, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary and Gastrointestinal Surgery, Sichuan Provincial Cancer Hospital, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Lang
authors.initials: L
authors.lastname: Tian
authors.affiliation: Department of Hepatobiliary and Gastrointestinal Surgery, Sichuan Provincial Cancer Hospital, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Aixiang
authors.initials: A
authors.lastname: Liu
mesh_terms: D020413:3' Untranslated Regions; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D011379:Prognosis; D016019:Survival Analysis; D043222:Ubiquitin Thiolesterase / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; C000605129:MIRN4728 microRNA, human; D035683:MicroRNAs; C509299:USP14 protein, human; D043222:Ubiquitin Thiolesterase