title: Serotonin in peripheral blood reflects oxidative stress and plays a crucial role in atherosclerosis: Novel insights toward holistic anti-atherothrombotic strategy.
abstract: We enrolled 132 outpatients with cardiovascular risk factors to evaluate the serotonin levels in platelet-poor plasma (PPP) and whole blood (WB). PPP serotonin levels and PPP/WB serotonin ratio were significantly correlated with levels of oxidative stress measured by derivative reactive oxygen metabolites (d-ROM). Twenty-five subjects were revealed to have stable coronary artery disease (CAD), and the levels CRP, d-ROM, and PPP/WB serotonin ratio were significantly higher in subjects with CAD than in those without CAD. Logistic regression analysis performed with the endpoint of having CAD revealed that the PPP/WB serotonin ratio was independently associated with CAD (odds ratio 3.37, 95% confidence interval 1.04-10.9, P = 0.04). Receiver operating characteristic (ROC) curve analyses to discriminate subjects with CAD from those without CAD indicated that combining PPP/WB serotonin ratio and d-ROM improved diagnostic utility. Targeting the serotonin-oxidative stress axis as part of a holistic anti-atherothrombotic strategy could be beneficial for patients with atherosclerosis.
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan. Electronic address: tomosugi@med.nagoya-cu.ac.jp.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Sugiura
authors.affiliation: Department of Internal Medicine, Faculty of Rehabilitation, Nagoya Gakuin University, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Dohi
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan.
authors.forename: Sumiyo
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Department of Health Sciences, Saitama Prefectural University, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hirowatari
authors.affiliation: Department of Laboratory Medicine, Asahikawa Medical University, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujii
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohte
mesh_terms: D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D003430:Cross-Sectional Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D012372:ROC Curve; D017382:Reactive Oxygen Species / Q000097:blood; D012701:Serotonin / Q000097:blood*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D005343:Fibrinolytic Agents; D017382:Reactive Oxygen Species; D012701:Serotonin; D002097:C-Reactive Protein
keywords: Atherosclerosis; Cardiovascular risk factor; Coronary artery disease; Oxidative stress; Serotonin