title: Ocean acidification increases cadmium accumulation in marine bivalves: a potential threat to seafood safety.
abstract: To date, the effects of ocean acidification on toxic metals accumulation and the underlying molecular mechanism remains unknown in marine bivalve species. In the present study, the effects of the realistic future ocean pCO2 levels on the cadmium (Cd) accumulation in the gills, mantle and adductor muscles of three bivalve species, Mytilus edulis, Tegillarca granosa, and Meretrix meretrix, were investigated. The results obtained suggested that all species tested accumulated significantly higher Cd (p < 0.05) in the CO2 acidified seawater during the 30 days experiment and the health risk of Cd (based on the estimated target hazard quotients, THQ) via consumption of M. meretrix at pH 7.8 and 7.4 significantly increased 1.21 and 1.32 times respectively, suggesting a potential threat to seafood safety. The ocean acidification-induced increase in Cd accumulation may have occurred due to (i) the ocean acidification increased the concentration of Cd and the Cd(2+)/Ca(2+) in the seawater, which in turn increased the Cd influx through Ca channel; (ii) the acidified seawater may have brought about epithelia damage, resulting in easier Cd penetration; and (iii) ocean acidification hampered Cd exclusion.
authors.affiliation: College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China.
authors.forename: Xinguo
authors.initials: X
authors.lastname: Zhao
authors.affiliation: College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.affiliation: Marine Monitoring and Forecasting Center of Zhejiang, Hangzhou, 310007, P.R. China.
authors.forename: Zhumei
authors.initials: Z
authors.lastname: Che
authors.affiliation: Zhejiang Mariculture Research Institute, Wenzhou, 325005, P.R. China.
authors.forename: Xueliang
authors.initials: X
authors.lastname: Chai
authors.affiliation: College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China.
authors.forename: Guangxu
authors.initials: G
authors.lastname: Liu
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000378:metabolism; D000143:Acids / Q000737:chemistry*; D000818:Animals; D059001:Aquatic Organisms / Q000235:genetics / Q000378:metabolism*; D049872:Bivalvia / Q000235:genetics / Q000378:metabolism*; D002104:Cadmium / Q000032:analysis / Q000378:metabolism*; D002118:Calcium / Q000032:analysis; D002245:Carbon Dioxide; D059022:Food Safety; D005786:Gene Expression Regulation; D000075322:Heavy Metal Poisoning; D009792:Oceans and Seas; D011041:Poisoning; D017747:Seafood / Q000009:adverse effects*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000143:Acids; D002104:Cadmium; D002245:Carbon Dioxide; D002118:Calcium