title: Adipocytokines, inflammatory and oxidative stress markers of clinical relevance altered in young overweight/obese subjects.
abstract: OBJECTIVE
  The aim of the study was to assess the influence of overweight and obesity in youth on adipocytokines levels, inflammatory and oxidative markers.
  
  
  METHODS
  Cross-sectional study of 149 young adults (54 normal weight, 27 overweight, 68 obese).Clinical and biochemical parameters, including lipid profile, fasting glucose, insulin and HOMA were determined. The levels of adipocytokines(adiponectin, retinol-binding protein 4 (RBP4), and resistin), markers of inflammation (high-sensitivity C-reactive protein (hs-CRP) adenosine deaminase (ADA), dipeptidyl peptidase-IV (DPP-IV) activities, serum IL-6 levels and oxidative stress (malondialdehyde and ferric reducing antioxidant power - FRAP) were measured.
  
  
  RESULTS
  Obese subjects presented significantly lower levels of Sulfhydryl groups (SH groups), adiponectin, HDL-C and the highest levels of RBP4, hs-CRP, resistin, IL-6, ADA, DPP-IV activities, and oxidative markers than compared to those who were of normal weight. There was a positive correlation between hs-CRP, IL-6, DDP-IV activity, anthropometric measurements and biochemical parameters.
  
  
  CONCLUSIONS
  This analysis shows that resistin, RBP4, IL-6, ADA and DPP-IV activities and the reduction of adiponectin can promote inflammation, impairment of insulin sensitivity, and may contribute development of the pathways involved in obesity. These findings may hold promise in identifying new inflammatory markers, benchmarks that assist in the diagnosis and monitoring of patients with overweight and obese.
authors.affiliation: Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil; Center Healthy Sciences, University of West of Santa Catarina, UNOESC, 89900-000 São Miguel do Oeste, SC, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ottobelli Chielle
authors.affiliation: Center Healthy Sciences, University of West of Santa Catarina, UNOESC, 89900-000 São Miguel do Oeste, SC, Brazil.
authors.forename: Willian Marciel
authors.initials: WM
authors.lastname: de Souza
authors.affiliation: Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil.
authors.forename: Thainan Paz
authors.initials: TP
authors.lastname: da Silva
authors.affiliation: Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil; Center of Healthy Sciences, UFSM-Santa Maria-Brazil.
authors.forename: Rafael Noal
authors.initials: RN
authors.lastname: Moresco
authors.affiliation: Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil; Center of Healthy Sciences, UFSM-Santa Maria-Brazil. Electronic address: beatriz@smail.ufsm.br.
authors.forename: Maria Beatriz
authors.initials: MB
authors.lastname: Moretto
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism; D052242:Adiponectin / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D018836:Inflammation Mediators / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D050177:Overweight / Q000503:physiopathology*; D018384:Oxidative Stress; D011379:Prognosis; D052243:Resistin / Q000378:metabolism; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D018836:Inflammation Mediators; D007328:Insulin; D015850:Interleukin-6; C101326:RBP4 protein, human; C499624:RETN protein, human; D052243:Resistin; D054839:Retinol-Binding Proteins, Plasma; D002097:C-Reactive Protein; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4; C548482:ADA protein, human; D000243:Adenosine Deaminase
keywords: Adenosine deaminase; Adipocytokines; Dipeptidyl peptidase-IV; Obesity; Young adult