title: CanisOme--The protein signatures of Canis lupus familiaris diseases.
abstract: Although the applications of Proteomics in Human Biomedicine have been explored for some time now, in animal and veterinary research, the potential of this resource has just started to be explored, especially when companion animal health is considered. In the last years, knowledge on the Canis lupus familiaris proteome has been accumulating in the literature and a resource compiling all this information and critically reviewing it was lacking. This article presents such a resource for the first time. CanisOme is a database of all proteins identified in Canis lupus familiaris tissues, either in health or in disease, annotated with information on the proteins present on the sample and on the donors. This database reunites information on 549 proteins, associated with 63 dog diseases and 33 dog breeds. Examples of how this information may be used to produce new hypothesis on disease mechanisms is presented both through the functional analysis of the proteins quantified in canine cutaneous mast cell tumors and through the study of the interactome of C. lupus familiaris and Leishmania infantum. Therefore, the usefulness of CanisOme for researchers looking for protein biomarkers in dogs and interested in a comprehensive analysis of disease mechanisms is demonstrated.
  
  
  CONCLUSIONS
  This paper presents CanisOme, a database of proteomic studies with relevant protein annotation, allowing the enlightenment of disease mechanisms and the discovery of novel disease biomarkers for C. lupus familiaris. This knowledge is important not only for the improvement of animal health but also for the use of dogs as models for human health studies.
authors.affiliation: Department of Health Sciences, Center for Interdisciplinary Research in Health (CIIS), Universidade Católica Portuguesa, Viseu, Portugal.
authors.forename: Mónica
authors.initials: M
authors.lastname: Fernandes
authors.affiliation: Department of Health Sciences, Center for Interdisciplinary Research in Health (CIIS), Universidade Católica Portuguesa, Viseu, Portugal.
authors.forename: Nuno
authors.initials: N
authors.lastname: Rosa
authors.affiliation: Department of Health Sciences, Center for Interdisciplinary Research in Health (CIIS), Universidade Católica Portuguesa, Viseu, Portugal.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Esteves
authors.affiliation: Department of Health Sciences, Center for Interdisciplinary Research in Health (CIIS), Universidade Católica Portuguesa, Viseu, Portugal.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Correia
authors.affiliation: Department of Informatics Engineering (DEI), Centre for Informatics and Systems of the University of Coimbra (CISUC), University of Coimbra, 3030-290 Coimbra, Portugal.
authors.forename: Joel
authors.initials: J
authors.lastname: Arrais
authors.affiliation: Center for Interdisciplinary Research in Health (CIIS), Universidade Católica Portuguesa, Viseu, Portugal.
authors.forename: Paulo
authors.initials: P
authors.lastname: Ribeiro
authors.affiliation: Escola Superior Agrária de Viseu, Instituto Politécnico de Viseu, Portugal; Centro de Estudos em Educação, Tecnologias e Saúde, Instituto Politécnico de Viseu, Portugal.
authors.forename: Helena
authors.initials: H
authors.lastname: Vala
authors.affiliation: Department of Health Sciences, Center for Interdisciplinary Research in Health (CIIS), Universidade Católica Portuguesa, Viseu, Portugal. Electronic address: mbarros@crb.ucp.pt.
authors.forename: Marlene
authors.initials: M
authors.lastname: Barros
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D030562:Databases, Protein; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D006801:Humans; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: Canis DiseasOme; Canis Leishmaniosis; Canis biomarkers; CanisOme