title: Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002-2014: a multicentre retrospective cross-sectional study.
abstract: Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognized hazard. We report a multicentre retrospective cross-sectional study undertaken in Turkey in 2014 in nine hospitals, regional reference centres for CCHF, covering the years 2002 to 2014 inclusive. Data were systematically extracted from charts of all personnel with a reported health care injury/accident related to CCHF. Blood samples were tested for CCHF IgM/IgG by enzyme-linked immunosorbent assay and/or viral nucleic acid detection by PCR after the injury. Fifty-one healthcare-related exposures were identified. Twenty-five (49%) of 51 resulted in laboratory-confirmed infection, with a 16% (4/25) overall mortality. The main route of exposure was needlestick injury in 32/51 (62.7%). A potential benefit of post-exposure prophylaxis with ribavirin was identified.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University Medical School, Samsun, Turkey. Electronic address: hakanomu@yahoo.com.
authors.forename: H
authors.initials: H
authors.lastname: Leblebicioglu
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University Medical School, Samsun, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Sunbul
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Yildirim Beyazit University Medical School, Ankara, Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Guner
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Bodur
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Ankara Research and Training Hospital, Ankara, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Bulut
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpasa University Medical School, Tokat, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Duygu
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University Medical School, Sivas, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Elaldi
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, SB Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Cicek Senturk
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Ataturk University Medical School, Erzurum, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Ozkurt
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Karadeniz Technical University Medical School, Erzurum, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Yilmaz
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University Medical School, Samsun, Turkey; Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
authors.forename: T E
authors.initials: TE
authors.lastname: Fletcher
authors.affiliation: Liverpool School of Tropical Medicine, Liverpool, United Kingdom; NIHR HPRU in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, United Kingdom.
authors.forename: N J
authors.initials: NJ
authors.lastname: Beeching
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology; D006479:Hemorrhagic Fever, Crimean / Q000453:epidemiology* / Q000401:mortality; D006761:Hospitals; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016602:Needlestick Injuries / Q000150:complications; D009784:Occupational Diseases / Q000453:epidemiology* / Q000401:mortality; D016273:Occupational Exposure; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000097:blood; D012189:Retrospective Studies; D016019:Survival Analysis; D014421:Turkey / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral
keywords: Crimean-Congo haemorrhagic fever; healthcare associated; infection prevention and control; ribavirin; viral haemorrhagic fever