title: CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis.
abstract: Elevated CXCL13 within the central nervous system (CNS) correlates with humoral responses in several neuroinflammatory diseases, yet its role is controversial. During coronavirus encephalomyelitis CXCL13 deficiency impaired CNS accumulation of memory B cells and antibody-secreting cells (ASC) but not naïve/early-activated B cells. However, despite diminished germinal center B cells and follicular helper T cells in draining lymph nodes, ASC in bone marrow and antiviral serum antibody were intact in the absence of CXCL13. The data demonstrate that CXCL13 is not essential in mounting effective peripheral humoral responses, but specifically promotes CNS accumulation of differentiated B cells.
authors.affiliation: Department of Neurosciences NC30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, USA. Electronic address: pharest@ccf.org.
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Phares
authors.affiliation: Department of Neurosciences NC30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, USA; School of Biomedical Sciences, Kent State University, Kent, OH, USA. Electronic address: disanok@ccf.org.
authors.forename: Krista D
authors.initials: KD
authors.lastname: DiSano
authors.affiliation: Department of Neurosciences NC30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, USA. Electronic address: stohlms2@ccf.org.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Stohlman
authors.affiliation: Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: bmsegal@med.umich.edu.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Segal
authors.affiliation: Department of Neurosciences NC30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, USA. Electronic address: bergmac@ccf.org.
authors.forename: Cornelia C
authors.initials: CC
authors.lastname: Bergmann
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002465:Cell Movement / Q000276:immunology; D002490:Central Nervous System / Q000276:immunology*; D054382:Chemokine CXCL13 / Q000276:immunology*; D018352:Coronavirus Infections / Q000276:immunology* / Q000473:pathology; D004679:Encephalomyelitis / Q000276:immunology* / Q000473:pathology; D005260:Female; D017578:Immunoglobulin Class Switching / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D054382:Chemokine CXCL13; C486386:Cxcl13 protein, mouse
keywords: Antibody secreting cells; B cells; CXCL13; Central nervous system; Memory B cells; Neuroimmunology