title: 1,1'-Carbonyldiimidazole (CDI) Mediated Coupling and Cyclization To Generate [1,2,4]Triazolo[4,3-a]pyridines.
abstract: An operationally efficient CDI mediated tandem coupling and cyclization reaction to generate [1,2,4]triazolo[4,3-a]pyridines has been reported. The reaction conditions and scope were investigated, and the methodology was demonstrated in batch mode as well as in a continuous process.
authors.affiliation: Drug Substance Technologies, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 31320, United States.
authors.forename: Kyle D
authors.initials: KD
authors.lastname: Baucom
authors.affiliation: Drug Substance Technologies, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 31320, United States.
authors.forename: Siân C
authors.initials: SC
authors.lastname: Jones
authors.affiliation: Drug Substance Technologies, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 31320, United States.
authors.forename: Scott W
authors.initials: SW
authors.lastname: Roberts
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007093:Imidazoles; D011725:Pyridines; D014230:Triazoles; C006900:N,N-carbonyldiimidazole