title: Effects of Al(3+) on Phosphocholine and Phosphoglycerol Containing Solid Supported Lipid Bilayers.
abstract: Aluminum has attracted great attention recently as it has been suggested by several studies to be associated with increased risks for Alzheimer's and Parkinson's disease. The toxicity of the trivalent ion is assumed to derive from structural changes induced in lipid bilayers upon binding, though the mechanism of this process is still not well understood. In the present study we elucidate the effect of Al(3+) on supported lipid bilayers (SLBs) using fluorescence microscopy, the quartz crystal microbalance with dissipation (QCM-D) technique, dual-polarization interferometry (DPI), and molecular dynamics (MD) simulations. Results from these techniques show that binding of Al(3+) to SLBs containing negatively charged and neutral phospholipids induces irreversible changes such as domain formation. The measured variations in SLB thickness, birefringence, and density indicate a phase transition from a disordered to a densely packed ordered phase.
authors.affiliation: Department of Chemistry, Pomona College , 645 North College Ave., Claremont, California 91711, United States.
authors.forename: Hannah K
authors.initials: HK
authors.lastname: Wayment-Steele
authors.affiliation: Department of Applied Physics, Chalmers University of Technology , 412 96 Göteborg, Sweden.
authors.forename: Yujia
authors.initials: Y
authors.lastname: Jing
authors.affiliation: Swann Scientific Consulting Ltd., 110 Sandy Lane, Lymm, Cheshire, U.K.
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Swann
authors.affiliation: Department of Chemistry, Pomona College , 645 North College Ave., Claremont, California 91711, United States.|Department of Chemistry, University of Washington , 109 Bagley Hall, Seattle, Washington 98195, United States.
authors.forename: Lewis E
authors.initials: LE
authors.lastname: Johnson
authors.affiliation: Department of Applied Physics, Chalmers University of Technology , 412 96 Göteborg, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Agnarsson
authors.affiliation: Department of Applied Physics, Chalmers University of Technology , 412 96 Göteborg, Sweden.
authors.forename: Sofia
authors.initials: S
authors.lastname: Svedhem
authors.affiliation: Department of Chemistry, Pomona College , 645 North College Ave., Claremont, California 91711, United States.
authors.forename: Malkiat S
authors.initials: MS
authors.lastname: Johal
authors.affiliation: Department of Applied Physics, Chalmers University of Technology , 412 96 Göteborg, Sweden.|Institute of Physical Chemistry, University of Göttingen , 37077 Göttingen, Germany.
authors.forename: Angelika
authors.initials: A
authors.lastname: Kunze
mesh_terms: D000535:Aluminum / Q000494:pharmacology*; D004058:Diffusion; D005994:Glycerophosphates / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D010767:Phosphorylcholine / Q000737:chemistry*
chemical_list: D005994:Glycerophosphates; D008051:Lipid Bilayers; D010767:Phosphorylcholine; C029620:alpha-glycerophosphoric acid; D000535:Aluminum