title: Interleukin-2 Receptor and Angiotensin-Converting Enzyme as Markers for Ocular Sarcoidosis.
abstract: OBJECTIVE
  To study the impact of soluble IL2 receptor (sIL2R), chest x-ray (CxR), and angiotensin-converting enzyme (ACE) as markers for sarcoidosis in uveitis patients.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Serum concentrations of sIL2R and ACE were measured in patients with active uveitis. Those with elevated sIL2R and /or ACE values were examined for suspected systemic sarcoidosis.
  
  
  METHODS
  Our main outcome parameters were the specificity and sensitivity of sIL2R, CxR and ACE in screening for ocular sarcoidosis.
  
  
  RESULTS
  We measured 261 patients with uveitis for sarcoidosis using sIL2R and ACE between January 2008 and November 2011; sarcoidosis was been diagnosed using other tests (e.g. computer tomography, brochoalveolar lavage, biopsy) in 41 of 53 patients with elevated sIL2R values (>639 U/ml) and in one patient with normal sIL2R (582 U/ml). Their mean sIL2R value was 1310 U/ml, extending from 582 to 8659 U/ml. Only 9 patients, however, presented elevated ACE (>82 U/l). Their mean ACE value was 116.4 U/l, ranging from 84.1 to 175.5 U/l. IL2R specificity was 94% with 98% sensitivity. In contrast, ACE had a specificity of 99.5%, but a sensitivity of only 22%; the chest x-ray had a specificity of 100% with 50% sensitivity in detecting sarcoidosis. We observed the entire spectrum of uveitis: sixteen patients suffered from anterior, 8 from intermediate, 16 from posterior, and 2 from panuveitis.
  
  
  CONCLUSIONS
  An elevated level of soluble IL2R suggests sarcoidosis with uveitis more convincingly than ACE, making sIL2R a more effective marker parameter for sarcoidosis than ACE or chest x-ray in uveitis patients.
authors.affiliation: University Eye Hospital Charite, Berlin, Germany.|Eye Center, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Enken
authors.initials: E
authors.lastname: Gundlach
authors.affiliation: Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Michael Marcus
authors.initials: MM
authors.lastname: Hoffmann
authors.affiliation: Department of Pneumology, University Hospital Freiburg, Freiburg, Germany.|Department Respiratory Medicine Medical School Hannover, Hannover, Germany.|Clinical Research Center Fraunhofer ITEM, Hannover, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Prasse
authors.affiliation: Eye Center, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Heinzelmann
authors.affiliation: Eye Center, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ness
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D013902:Radiography, Thoracic; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D014605:Uveitis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015375:Receptors, Interleukin-2; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A