title: Atypical development of the central auditory system in young children with Autism spectrum disorder.
abstract: The P1m component of the auditory evoked magnetic field is the earliest cortical response associated with language acquisition. However, the growth curve of the P1m component is unknown in both typically developing (TD) and atypically developing children. The aim of this study is to clarify the developmental pattern of this component when evoked by binaural human voice stimulation using child-customized magnetoencephalography. A total of 35 young TD children (32-121 months of age) and 35 children with autism spectrum disorder (ASD) (38-111 months of age) participated in this study. This is the first report to demonstrate an inverted U-shaped growth curve for the P1m dipole intensity in the left hemisphere in TD children. In addition, our results revealed a more diversified age-related distribution of auditory brain responses in 3- to 9-year-old children with ASD. These results demonstrate the diversified growth curve of the P1m component in ASD during young childhood, which is a crucial period for first language acquisition. Autism Res 2016, 9: 1216-1226. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.
authors.affiliation: Institute of Human and Social Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.|Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoshimura
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.|Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kikuchi
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Hiraishi
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Hasegawa
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: International Education Center, Kyushu University, Fukuoka, 815-8540, Japan.
authors.forename: Gerard B
authors.initials: GB
authors.lastname: Remijn
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Oi
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.|Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Munesue
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Higashida
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.|Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Minabe
authors.affiliation: Institute of Human and Social Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Kojima
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000067877:Autism Spectrum Disorder / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male
keywords: P1m; autism spectrum disorder; magnetoencephalography; young children