title: Polyanionic Macromolecular Prodrugs of Ribavirin: Antiviral Agents with a Broad Spectrum of Activity.
abstract: Macromolecular prodrugs are developed as multiarmed agents against diverse viral pathogens. Lead candidates inhibit infectivity and replication of HIV, Ebola, influenza, measles, RSV, etc-thus being broad-spectrum antiviral agents.
authors.affiliation: CSIRO-Health and Biosecurity Flagship, Australian Animal Health Laboratory, Geelong, VIC, 3220, Australia.
authors.forename: Tracey M
authors.initials: TM
authors.lastname: Hinton
authors.affiliation: Department of Infectious Diseases, Aarhus University Hospital, 8000, Aarhus C, Denmark.|Department of Chemistry and the iNano, Interdisciplinary Nanoscience Centre, Aarhus University, 8000, Aarhus C, Denmark.
authors.forename: Kaja
authors.initials: K
authors.lastname: Zuwala
authors.affiliation: CSIRO-Health and Biosecurity Flagship, Australian Animal Health Laboratory, Geelong, VIC, 3220, Australia.
authors.forename: Celine
authors.initials: C
authors.lastname: Deffrasnes
authors.affiliation: CSIRO-Health and Biosecurity Flagship, Australian Animal Health Laboratory, Geelong, VIC, 3220, Australia.
authors.forename: Shawn
authors.initials: S
authors.lastname: Todd
authors.affiliation: CSIRO-Health and Biosecurity Flagship, Australian Animal Health Laboratory, Geelong, VIC, 3220, Australia.
authors.forename: Shuning
authors.initials: S
authors.lastname: Shi
authors.affiliation: CSIRO-Health and Biosecurity Flagship, Australian Animal Health Laboratory, Geelong, VIC, 3220, Australia.
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Marsh
authors.affiliation: CSIRO-Health and Biosecurity Flagship, Australian Animal Health Laboratory, Geelong, VIC, 3220, Australia.
authors.forename: Megan
authors.initials: M
authors.lastname: Dearnley
authors.affiliation: Department of Chemistry and the iNano, Interdisciplinary Nanoscience Centre, Aarhus University, 8000, Aarhus C, Denmark.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Wohl
authors.affiliation: Department of Infectious Diseases, Aarhus University Hospital, 8000, Aarhus C, Denmark.
authors.forename: Martin
authors.initials: M
authors.lastname: Tolstrup
authors.affiliation: Department of Chemistry and the iNano, Interdisciplinary Nanoscience Centre, Aarhus University, 8000, Aarhus C, Denmark.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Zelikin
mesh_terms: D000072283:A549 Cells; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002642:Chick Embryo; D006367:HeLa Cells; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D046911:Macromolecular Substances / Q000737:chemistry*; D000071228:Polyelectrolytes; D011108:Polymers / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology*; D012254:Ribavirin / Q000737:chemistry / Q000494:pharmacology*; D052736:Rous sarcoma virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D046911:Macromolecular Substances; D000071228:Polyelectrolytes; D011108:Polymers; D011355:Prodrugs; D012254:Ribavirin
keywords: antiviral agents; broad-spectrum antiviral agents; macromolecular prodrugs