title: Impact of endometrial cavity fluid on assisted reproductive technology outcomes.
abstract: BACKGROUND
  The impact of endometrial cavity fluid (ECF) on assisted reproductive technology (ART) outcomes has not been evaluated in a meta-analysis.
  
  
  OBJECTIVE
  To evaluate the impact of ECF on the outcome of ART cycles.
  
  
  METHODS
  PubMed, China Academic Journals Full-text Database, and China Doctoral/Masters Dissertations Full-text Databases were searched for reports published in any language before January 1, 2015, using relevant keywords.
  
  
  METHODS
  Studies were included if they compared the outcome of ART in women with and without ECF.
  
  
  METHODS
  Background information, participants' characteristics, and study outcomes were recorded. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the Mantel-Haenszel method.
  
  
  RESULTS
  Six studies evaluating 5928 ART cycles were included. The pregnancy rate was significantly lower in the group with ECF than in the group without ECF (OR 0.74, 95% CI 0.55-0.98; P=0.03). The same association was observed if the analysis included only patients with hydrosalpinx (OR 0.36, 95% CI 0.15-0.86; P=0.02).
  
  
  CONCLUSIONS
  The clinical pregnancy rate after ART is significantly lower among patients with ECF than among those without ECF. In addition, if ECF is found in patients with hydrosalpinx, ART cycles should be cancelled after oocyte retrieval.
authors.affiliation: Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Immunology and Microbiology, Xi'an Jiaotong University Health Science Center, Xi'an, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Shi
authors.affiliation: Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China. Electronic address: shijuanzi123@126.com.
authors.forename: Juanzi
authors.initials: J
authors.lastname: Shi
mesh_terms: D001826:Body Fluids / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D054315:Oocyte Retrieval / Q000592:standards*; D010062:Ovulation Induction / Q000592:standards*; D011247:Pregnancy; D018873:Pregnancy Rate
keywords: Assisted reproductive technology; Endometrial cavity fluid; Hydrosalpinx; Meta-analysis; Pregnancy rate