title: Poly(p-phenylene) with Poly(ethylene glycol) Chains and Amino Groups as a Functional Platform for Controlled Drug Release and Radiotherapy.
abstract: Conventional cancer treatments such as chemotherapy, radiotherapy, or combination of these two result in side effects, which lower the quality of life of the patients. To overcome problems with these methods, altering the drug properties by conjugating them to carrier polymers has emerged. Such polymeric carriers also hold the potential to make tumor cells more sensitive to radiation therapy. Herein, poly(p-phenylene) (PPP) polymer with poly(ethylene glycol) (PEG) chains and primary amino groups (PPP-NH2 -g-PEG) is synthesized and conjugated with anticancer drug Doxorubicin (DOX). pH dependent drug release experiments are performed at pH 5.3 and pH 7.4, respectively. Cell viability studies on human cervix adenocarcinoma cells show that lower doses of DOX inhibit cell proliferation when conjugated with nontoxic doses of PPP-NH2 -g-PEG polymer. Additionally, PPP-NH2 -g-PEG/Cys/DOX bioconjugate significantly increases radiosensitive properties of DOX. It is possible to use lower doses of DOX when conjugated to PPP-NH2 -g-PEG in combination with radiotherapy.
authors.affiliation: Department of Biochemistry, Faculty of Science, Ege University, 35100, Bornova, Izmir, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Guler
authors.affiliation: Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34467, Istanbul, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Akbulut
authors.affiliation: Department of Biochemistry, Faculty of Science, Ege University, 35100, Bornova, Izmir, Turkey.
authors.forename: Firat Baris
authors.initials: FB
authors.lastname: Barlas
authors.affiliation: Institute on Drug Abuse, Toxicology & Pharmaceutical Sciences, Ege University, 35100, Bornova, Izmir, Turkey.
authors.forename: Caner
authors.initials: C
authors.lastname: Geyik
authors.affiliation: Department of Biochemistry, Faculty of Science, Ege University, 35100, Bornova, Izmir, Turkey.
authors.forename: Dilek Odaci
authors.initials: DO
authors.lastname: Demirkol
authors.affiliation: Sifa University Hospital, 35100, Bornova, Izmir, Turkey.
authors.forename: Ahmet Murat
authors.initials: AM
authors.lastname: Senisik
authors.affiliation: Vocational School of Health Services, Radiotheraphy Department, Sifa University, Buca, 35370, Izmir, Turkey.
authors.forename: Halil Armagan
authors.initials: HA
authors.lastname: Arican
authors.affiliation: Institute on Drug Abuse, Toxicology & Pharmaceutical Sciences, Ege University, 35100, Bornova, Izmir, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Coskunol
authors.affiliation: Department of Biochemistry, Faculty of Science, Ege University, 35100, Bornova, Izmir, Turkey.|Institute on Drug Abuse, Toxicology & Pharmaceutical Sciences, Ege University, 35100, Bornova, Izmir, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Timur
authors.affiliation: Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34467, Istanbul, Turkey.|Center of Excellence for Advanced Materials Research (CEAMR) and Chemistry DepartmentFaculty of Science, King Abdulaziz University, PO Box 80203, Jeddah, 21589, Saudi Arabia.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yagci
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D005260:Female; D006801:Humans; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: bioconjugation; drug release; graft copolymer; poly(p-phenylene)s; radiosensitivity