title: Osteogenic response and osteoprotective effects in vivo of a nanostructured titanium surface with antibacterial properties.
abstract: In implantology, as an alternative approach to the use of antibiotics, direct surface modifications of the implant addressed to inhibit bacterial adhesion and to limit bacterial proliferation are a promising tactic. The present study evaluates in an in vivo normal model the osteogenic response and the osteointegration of an anodic spark deposition nanostructured titanium surface doped with gallium (ASD + Ga) in comparison with two other surface treatments of titanium: an anodic spark deposition treatment without gallium (ASD) and an acid etching treatment (CTR). Moreover the study assesses the osteoprotective potential and the antibacterial effect of the previously mentioned surface treatments in an experimentally-induced peri-implantitis model. The obtained data points out a more rapid primary fixation in ASD and ASD + Ga implants, compared with CTR surface. Regarding the antibacterial properties, the ASD + Ga surface shows osteoprotective action on bone peri-implant tissue in vivo as well as an antibacterial effect within the first considered time point.
authors.affiliation: Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126, Parma, Italy. francesca.ravanetti@unipr.it.
authors.forename: F
authors.initials: F
authors.lastname: Ravanetti
authors.affiliation: Department of Chemistry, Materials and Materials Engineering "G. Natta", Politecnico di Milano, Via Mancinelli 7, 20131, Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Chiesa
authors.affiliation: Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126, Parma, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Ossiprandi
authors.affiliation: Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126, Parma, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Gazza
authors.affiliation: Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100, Sassari, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Farina
authors.affiliation: Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126, Parma, Italy.
authors.forename: F M
authors.initials: FM
authors.lastname: Martini
authors.affiliation: Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126, Parma, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Di Lecce
authors.affiliation: Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126, Parma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Gnudi
authors.affiliation: Department of Chemistry, Materials and Materials Engineering "G. Natta", Politecnico di Milano, Via Mancinelli 7, 20131, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Della Valle
authors.affiliation: Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126, Parma, Italy.
authors.forename: J
authors.initials: J
authors.lastname: Gavini
authors.affiliation: Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126, Parma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cacchioli
mesh_terms: D000818:Animals; D005264:Femoral Fractures / Q000473:pathology / Q000601:surgery; D005708:Gallium / Q000009:adverse effects / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry*; D010012:Osteogenesis; D019736:Prostheses and Implants; D016459:Prosthesis-Related Infections / Q000473:pathology; D011817:Rabbits; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods; D014025:Titanium
chemical_list: D005708:Gallium; D014025:Titanium