title: Adult Prevalence of Epilepsy in Spain: EPIBERIA, a Population-Based Study.
abstract: BACKGROUND
  This study assesses the lifetime and active prevalence of epilepsy in Spain in people older than 18 years.
  
  
  METHODS
  EPIBERIA is a population-based epidemiological study of epilepsy prevalence using data from three representative Spanish regions (health districts in Zaragoza, Almería, and Seville) between 2012 and 2013. The study consisted of two phases: screening and confirmation. Participants completed a previously validated questionnaire (EPIBERIA questionnaire) over the telephone.
  
  
  RESULTS
  A total of 1741 valid questionnaires were obtained, including 261 (14.99%) raising a suspicion of epilepsy. Of these suspected cases, 216 (82.75%) agreed to participate in phase 2. Of the phase 2 participants, 22 met the International League Against Epilepsy's diagnostic criteria for epilepsy. The estimated lifetime prevalence, adjusted by age and sex per 1,000 people, was 14.87 (95% CI: 9.8-21.9). Active prevalence was 5.79 (95% CI: 2.8-10.6). No significant age, sex, or regional differences in prevalence were detected.
  
  
  CONCLUSIONS
  EPIBERIA provides the most accurate estimate of epilepsy prevalence in the Mediterranean region based on its original methodology and its adherence to ILAE recommendations. We highlight that the lifetime prevalence and inactive epilepsy prevalence figures observed here were compared to other epidemiological studies.
authors.affiliation: Unidad de Neurología y Neurofisiología, Complejo Hospitalario Torrecárdenas, Calle Hermandad de Donantes de Sangre S/N, 04009 Almería, Spain.
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Serrano-Castro
authors.affiliation: Servicio de Neurología, Hospital Clínico Universitario Lozano Blesa, Avenida San Juan Bosco 15, 50009 Zaragoza, Spain.
authors.forename: Jose Angel
authors.initials: JA
authors.lastname: Mauri-Llerda
authors.affiliation: Unidad de Neurología, Hospital de Llerena, Avenida Badajoz 1, 06900 Llerena, Badajoz, Spain.
authors.forename: Francisco José
authors.initials: FJ
authors.lastname: Hernández-Ramos
authors.affiliation: Servicio de Neurología, Hospital Clínico Universitario San Cecilio, Calle Dr. Oloriz 16, 18012 Granada, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Sánchez-Alvarez
authors.affiliation: Servicio de Neurologia, Hospital Clínico San Carlos, Calle del Profesor Martín Lagos S/N, 28040 Madrid, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Parejo-Carbonell
authors.affiliation: Unidad de Neurología y Neurofisiología, Complejo Hospitalario Torrecárdenas, Calle Hermandad de Donantes de Sangre S/N, 04009 Almería, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Quiroga-Subirana
authors.affiliation: Unidad de Neurología y Neurofisiología, Complejo Hospitalario Torrecárdenas, Calle Hermandad de Donantes de Sangre S/N, 04009 Almería, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Vázquez-Gutierrez
authors.affiliation: Servicio de Neurología, Hospital Clínico Universitario Lozano Blesa, Avenida San Juan Bosco 15, 50009 Zaragoza, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Santos-Lasaosa
authors.affiliation: Servicio de Neurología, Hospital Universitario Virgen Macarena, Avenida Doctor Fedriani 3, 41071 Sevilla, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Mendez-Lucena
authors.affiliation: Servicio de Neurología, Hospital Universitario Virgen Macarena, Avenida Doctor Fedriani 3, 41071 Sevilla, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Redondo-Verge
authors.affiliation: Servicio de Neurología, Hospital Clínico Universitario Lozano Blesa, Avenida San Juan Bosco 15, 50009 Zaragoza, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Tejero-Juste
authors.affiliation: Servicio de Neurología, Hospital Clínico Universitario Lozano Blesa, Avenida San Juan Bosco 15, 50009 Zaragoza, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Morandeira-Rivas
authors.affiliation: Servicio de Neurología, Hospital General Universitario de Valencia, Calle de la Casa Misericordia 12, 46014 Valencia, Spain.
authors.forename: Jerónimo
authors.initials: J
authors.lastname: Sancho-Rieger
authors.affiliation: Servicio de Neurologia, Hospital Clínico San Carlos, Calle del Profesor Martín Lagos S/N, 28040 Madrid, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Matías-Guiu
mesh_terms: D000328:Adult; D000367:Age Factors; D004827:Epilepsy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D015995:Prevalence; D013030:Spain / Q000453:epidemiology; D055815:Young Adult