title: Association of LTβR gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population.
abstract: The lymphotoxin-β receptor (LTβR) gene is involved in autoimmune disease and inflammatory disorder development, but the relationship between LTβR and benign prostatic hyperplasia (BPH) is unclear. In total, 222 with BPH were examined for 3 single nucleotide polymorphisms [rs3759333 (-1387C/T), rs3759334 (-1326A/G), and rs2364480 (Ala172Ala)] located in the promoter and coding regions of LTβR using direct sequencing. The genotype distributions of rs3759334 were associated with prostate volume larger than 40 g. There were significant differences between the small (<40 g) and large (≥40 g) group subjects [codominant 1 model: odds ratio (OR) = 4.65, 95% confidence interval (CI) = 1.95-11.09, P = 0.001; dominant model: OR = 4.91, 95%CI = 2.07-11.63, P = 0.0002; log-additive model: OR = 4.81, 95%CI = 2.05-11.24, P = 0.0001]. The allele distributions of rs3759334 were significantly associated with BPH (OR = 4.87, 95%CI = 2.16-10.99, P = 0.0001). The distribution of rs2364480 was significantly different between groups (codominant 1 model: OR = 2.17, 95%CI = 1.11-4.26, P = 0.028; dominant model: OR = 2.16, 95%CI = 1.13-4.12, P = 0.019; log-additive model: OR = 1.86, 95%CI = 1.07-3.24, P = 0.027). The allele distribution of rs2364480 was significantly associated with BPH (OR = 1.88, 95%CI = 1.08-3.30, P = 0.027). We found that LTβR polymorphisms caused severe BPH. Thus, LTβR may contribute to the risk of BPH development.
authors.affiliation: Departments of Urology, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Kohwang Medical Research Institute and Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Departments of Urology, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Yoo
authors.affiliation: Kohwang Medical Research Institute and Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Departments of Urology, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: S G
authors.initials: SG
authors.lastname: Chang
mesh_terms: D000368:Aged; D000483:Alleles; D015415:Biomarkers; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053259:Lymphotoxin beta Receptor / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009929:Organ Size; D020641:Polymorphism, Single Nucleotide; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D056910:Republic of Korea
chemical_list: D015415:Biomarkers; D053259:Lymphotoxin beta Receptor