title: Isolation and absolute configurations of diastereomers of 8α-hydroxy-T-muurolol and (1α,6β,7β)-cadinane-4-en-8α,10α-diol from Chimonanthus salicifolius.
abstract: Phytochemical investigation of the aerial parts of Chimonanthus salicifolius resulted in the isolation of two sesquiterpenoids, 8α-hydroxy-T-muurolol and (1α,6β,7β)-cadinane-4-en-8α,10α-diol, together with 13 known compounds. The 15 structures were established by means of 1D and 2D NMR spectroscopy. The relative and absolute configurations of 8α-hydroxy-T-muurolol and 8α,11-elemodiol were achieved by NOESY experiments and X-ray crystallography using CuKα radiation. 8α-hydroxy-T-muurolol and (1α,6β,7β)-cadinane-4-en-8α,10α-diol showed immunosuppressive activities in a dose-dependent manner.
authors.affiliation: Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310018, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310018, PR China.
authors.forename: Yu-Yan
authors.initials: YY
authors.lastname: Jiang
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, PR China.
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Jin
authors.affiliation: Analysis & Testing Center, Soochow University, Suzhou 215123, Jiangsu, PR China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Li
authors.affiliation: Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310018, PR China.
authors.forename: Hu-Jun
authors.initials: HJ
authors.lastname: Xie
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.affiliation: Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310018, PR China. Electronic address: wkwnpc@zjgsu.edu.cn.
authors.forename: Kui-Wu
authors.initials: KW
authors.lastname: Wang
mesh_terms: D031237:Calycanthaceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D019906:Nuclear Magnetic Resonance, Biomolecular; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry*; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry*
chemical_list: D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C499351:T-muurolol; D013729:Terpenes; C508039:cadinane
keywords: (1α,6β,7β)-Cadinane-4-en-8α,10α-diol; 8α-Hydroxy-T-muurolol; Bioactivity; Calycanthaceae; Chimonanthus salicifolius; Sesquiterpene