title: Bedside Evaluation of the Functional Organization of the Auditory Cortex in Patients with Disorders of Consciousness.
abstract: To measure the level of residual cognitive function in patients with disorders of consciousness, the use of electrophysiological and neuroimaging protocols of increasing complexity is recommended. This work presents an EEG-based method capable of assessing at an individual level the integrity of the auditory cortex at the bedside of patients and can be seen as the first cortical stage of this hierarchical approach. The method is based on two features: first, the possibility of automatically detecting the presence of a N100 wave and second, in showing evidence of frequency processing in the auditory cortex with a machine learning based classification of the EEG signals associated with different frequencies and auditory stimulation modalities. In the control group of twelve healthy volunteers, cortical frequency processing was clearly demonstrated. EEG recordings from two patients with disorders of consciousness showed evidence of partially preserved cortical processing in the first patient and none in the second patient. From these results, it appears that the classification method presented here reliably detects signal differences in the encoding of frequencies and is a useful tool in the evaluation of the integrity of the auditory cortex. Even though the classification method presented in this work was designed for patients with disorders of consciousness, it can also be applied to other pathological populations.
authors.affiliation: Laboratoire de Mathématiques de Besançon, Besançon, France.|Cegos Deployment, Besançon, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Henriques
authors.affiliation: INSERM CIC 1431 Centre d'Investigation Clinique en Innovation Technologique, CHU de Besançon, Besançon, France.|EA 481 Laboratoire de Neurosciences de Besançon, Besançon, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Pazart
authors.affiliation: Laboratoire de Mathématiques de Besançon, Besançon, France.
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Grigoryeva
authors.affiliation: Service de neurologie, CHU de Besançon, Besançon, France.
authors.forename: Emelyne
authors.initials: E
authors.lastname: Muzard
authors.affiliation: Département douleur soins palliatifs, CHU de Besançon, Besançon, France.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Beaussant
authors.affiliation: INSERM CIC 1431 Centre d'Investigation Clinique en Innovation Technologique, CHU de Besançon, Besançon, France.|EA 481 Laboratoire de Neurosciences de Besançon, Besançon, France.|Service de Psychiatrie de l'adulte, CHU de Besançon, Besançon, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Haffen
authors.affiliation: INSERM CIC 1431 Centre d'Investigation Clinique en Innovation Technologique, CHU de Besançon, Besançon, France.|EA 481 Laboratoire de Neurosciences de Besançon, Besançon, France.|Service de neurologie, CHU de Besançon, Besançon, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Moulin
authors.affiliation: INSERM CIC 1431 Centre d'Investigation Clinique en Innovation Technologique, CHU de Besançon, Besançon, France.|EA 481 Laboratoire de Neurosciences de Besançon, Besançon, France.|Département douleur soins palliatifs, CHU de Besançon, Besançon, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Aubry
authors.affiliation: Laboratoire de Mathématiques de Besançon, Besançon, France.|Centre National de la Recherche Scientifique (CNRS), Paris, France.
authors.forename: Juan-Pablo
authors.initials: JP
authors.lastname: Ortega
authors.affiliation: INSERM CIC 1431 Centre d'Investigation Clinique en Innovation Technologique, CHU de Besançon, Besançon, France.|EA 481 Laboratoire de Neurosciences de Besançon, Besançon, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Gabriel
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000503:physiopathology*; D001307:Auditory Perception; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000503:physiopathology*