title: Flow Synthesis in Hot Water: Synthesis of the Atypical Antipsychotic Iloperidone.
abstract: Inductively heated steel reactors continuously perform organic transformations in water under high temperature conditions, utilizing the unique physiochemical properties of water at subcritical conditions. We demonstrated the power of this set-up in the continuous synthesis of the atypical antipsychotic drug iloperidone, in which we performed four out of five steps under aqueous conditions.
authors.affiliation: Institut für Organische Chemie, und Biomolekulares Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167, Hannover, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Hartwig
authors.affiliation: Institut für Organische Chemie, und Biomolekulares Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167, Hannover, Germany. andreas.kirschning@oci.uni-hannover.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kirschning
mesh_terms: D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature; D014867:Water
chemical_list: D014150:Antipsychotic Agents; D007555:Isoxazoles; D010880:Piperidines; D014867:Water; C081732:iloperidone
keywords: flow synthesis; high temperature; industrial chemistry; medicinal chemistry; synthetic methods