title: Obesity, metabolic syndrome and Mediterranean diet: Impact on depression outcome.
abstract: OBJECTIVE
  Obesity, metabolic syndrome (MetS) and low adherence to Mediterranean diet are frequent in major depression patients and have been separately related with prognosis. The aim of this study is to analyse their predictive power on major depression outcome, at 6 and 12 months.
  
  
  METHODS
  273 Major depressive patients completed the Beck Depression Inventory for depressive symptoms and the 14-item Mediterranean diet adherence score. MetS was diagnosed according to the International Diabetes Federation (IDF).
  
  
  RESULTS
  At the baseline Mediterranean diet adherence was inversely associated with depressive symptoms (p=0.007). Depression response was more likely in those patients with normal weight (p=0.006) and not MetS (p=0.013) but it was not associated with Mediterranean diet adherence (p=0.625). Those patients with MetS and obesity were less likely to improve symptoms of depression than patients with obesity but not MetS.
  
  
  CONCLUSIONS
  Obesity and MetS, but not low adherence to the Mediterranean diet at baseline, predicted a poor outcome of depression at 12 months. Our study suggests that MetS is the key factor that impacts negatively in depression prognosis, rather than obesity or diet. If this finding is confirmed, clinicians should be aware about MetS diagnosis and treatment in overweight depressed patients, especially if outcome is not being satisfactory enough.
authors.affiliation: University of Balearic Islands, Spain; Primary Care Prevention and Health Promotion Research Network, Spain.
authors.forename: M
authors.initials: M
authors.lastname: García-Toro
authors.affiliation: Primary Care Prevention and Health Promotion Research Network, Spain; Psychiatric Service, Parc Sanitari Sant Joan de Déu, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Vicens-Pons
authors.affiliation: University of Balearic Islands, Spain; Primary Care Prevention and Health Promotion Research Network, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gili
authors.affiliation: University of Balearic Islands, Spain; Primary Care Prevention and Health Promotion Research Network, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Roca
authors.affiliation: University of Balearic Islands, Spain. Electronic address: mj.serrano@uib.es.
authors.forename: M J
authors.initials: MJ
authors.lastname: Serrano-Ripoll
authors.affiliation: University of Balearic Islands, Spain; Primary Care Prevention and Health Promotion Research Network, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Vives
authors.affiliation: Primary Care Research Unit of Mallorca, Health Services-IbSalut, Instituto de Investigación Sanitaria, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Leiva
authors.affiliation: Instituto de Investigación Sanitaria de Palma, IdISPa, Spain.
authors.forename: A M
authors.initials: AM
authors.lastname: Yáñez
authors.affiliation: University of Balearic Islands, Spain; Department of Nursing, School of Nursing and Physiotherapy, University of Balearic Islands, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Bennasar-Veny
authors.affiliation: Primary Care Prevention and Health Promotion Research Network, Spain; Department of Psychology and Sociology, University of Zaragoza, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Oliván-Blázquez
mesh_terms: D003865:Major Depressive Disorder / Q000453:epidemiology*; D038441:Diet, Mediterranean / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000178:diet therapy / Q000523:psychology*; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000523:psychology*; D010349:Patient Compliance / Q000706:statistics & numerical data*; D012307:Risk Factors
keywords: Depression; Mediterranean diet; Metabolic syndrome; Obesity