title: Severe Intimal Thickening of Interlobular Arteries Revealed by a Renal Biopsy in an Adult with Prader-Willi Syndrome Complicated by IgA Nephropathy.
abstract: Renal complications are rare in patients with Prader-Willi syndrome (PWS). We herein experienced a 31-year-old woman with PWS, in whom a renal biopsy showed IgA nephropathy and severe intimal thickening of the interlobular arteries. The patient was admitted to our hospital due to proteinuria and microscopic hematuria after an upper respiratory infection. The occurrence of cardiovascular events has been reported as a cause of death in obese PWS patients. Because chronic kidney disease is generally a risk factor for cardiovascular disease, early detection checkups are essential in obese PWS patients to monitor the possible development of cardiovascular disease.
authors.affiliation: Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
authors.forename: Takayasu
authors.initials: T
authors.lastname: Ito
authors.forename: Eiji
authors.initials: E
authors.lastname: Ishikawa
authors.forename: Mika
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Murata
authors.forename: Norikazu
authors.initials: N
authors.lastname: Yamada
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ito
mesh_terms: D000328:Adult; D001158:Arteries / Q000473:pathology; D001706:Biopsy; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications*; D006417:Hematuria / Q000150:complications; D006801:Humans; D007668:Kidney / Q000473:pathology*; D009765:Obesity / Q000150:complications*; D011218:Prader-Willi Syndrome / Q000150:complications*; D011507:Proteinuria / Q000150:complications; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology*