title: Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulata.
abstract: Three new C-methylated and isoprenylated chalcone derivatives, dentichalcones A-C (1-3), together with six known compounds (4-9), were isolated from the twigs and leaves of Macaranga denticulata. Their structures were elucidated by spectroscopic analysis, including 1D, 2D NMR, and MS data. The known compounds, (2E)-1-(5,7-dihydroxy-2,2,6-trimethyl-2H-benzopyran-8-yl)-3-(4-methoxyphenyl)-2-propen-1-one (4), (2E)-1-(5,7-dihydroxy-2,2-dimethyl-2H-benzopyran-8-yl)-3-phenyl-2-propen-1-one (5), laxichalcone (6), macarangin (7), bonanniol A (8), and bonannione A (9), showed inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) in vitro. Three new C-methylated and isoprenylated chalcone derivatives, dentichalcones A-C (1-3), together with six known compounds, were isolated from the twigs and leaves of Macaranga denticulata. Some compounds showed inhibitory activities against PTP1B in vitro.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai, 201203, People's Republic of China.|Department of Chinese Medicine, School of Pharmacy, Xinxiang Medical University, 601 Jin Sui Road, Xinxiang, 453003, People's Republic of China.
authors.forename: Lai-Bin
authors.initials: LB
authors.lastname: Zhang
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai, 201203, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Lei
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai, 201203, People's Republic of China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Gao
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai, 201203, People's Republic of China.
authors.forename: Jing-Ya
authors.initials: JY
authors.lastname: Li
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai, 201203, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai, 201203, People's Republic of China. ajhou@shmu.edu.cn.
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
keywords: Dentichalcones A–C; Euphorbiaceae; Isoprenylated flavonoids; Macaranga denticulata; Protein tyrosine phosphatase 1B