title: The Framingham Heart Study--67 years of discovery in metabolic disease.
abstract: The Framingham Heart Study (FHS), initiated in 1948, is the longest running prospective cohort study in the USA. Through >65 years of discovery, the FHS has contributed to our understanding of obesity, type 2 diabetes mellitus and prediabetes mellitus, the metabolic syndrome and nonalcoholic fatty liver disease (NAFLD), and to how these conditions relate to our overall and cardiovascular-related mortality. This Timeline gives an overview of the substantial role the FHS has played in advancing the understanding of obesity, diabetes mellitus and NAFLD, and considers the direction the FHS will take in the years to come.
authors.affiliation: Division of Gastroenterology, Boston Medical Center, Boston University School of Medicine, 7th Floor, 85 East Concord Street, Boston, Massachusetts 02118, USA.
authors.forename: Michelle T
authors.initials: MT
authors.lastname: Long
authors.affiliation: National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Fox
mesh_terms: D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism; D006331:Heart Diseases / Q000453:epidemiology* / Q000378:metabolism; D006801:Humans; D008659:Metabolic Diseases / Q000453:epidemiology* / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology / Q000378:metabolism; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism