title: Protection by Edaravone, a Radical Scavenger, against Manganese-Induced Neurotoxicity in Rats.
abstract: Manganese (Mn) is a required element for biological systems; however, its excessive exposure may lead to a neurological syndrome known as manganism. The aim of the present study was to assess the toxic effects of subacute exposure of Mn by measuring weight gain, motor performance, and biochemical parameters (complex I activity, lipid peroxides, and protein carbonyls) in brain mitochondria in rats. We also examined whether edaravone (EDA), a radical scavenger, exerts protective effects against Mn-induced neurotoxicity. In addition, we evaluated the accumulation of Mn in brain regions using magnetic resonance imaging. Mn-exposed rats revealed significantly impaired motor performance, weight loss, and Mn accumulation in particular brain area. Lipid peroxides and protein carbonyls were significantly increased in Mn-exposed rats, whereas complex I activity was found to be decreased. EDA treatment significantly prevented mitochondrial oxidative damage and improved motor performance. These findings suggested that EDA might serve as a clinically effective agent against Mn-induced neurotoxicity.
authors.affiliation: Department of Physiology, School of Medicine, Ege University, Izmir, Turkey.|Department of Radiology, Atatürk Education and Training Hospital, Izmir Katip Çelebi University, Izmir, Turkey.
authors.forename: Melda
authors.initials: M
authors.lastname: Apaydin
authors.affiliation: Department of Physiology, School of Medicine, Istanbul Bilim University, Istanbul, Turkey.
authors.forename: Oytun
authors.initials: O
authors.lastname: Erbas
authors.affiliation: Department of Physiology, School of Medicine, Ege University, Izmir, Turkey. dilek.taskiran@ege.edu.tr.
authors.forename: Dilek
authors.initials: D
authors.lastname: Taskiran
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D002712:Chlorides; D000077553:Edaravone; D042967:Electron Transport Complex I / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D008297:Male; D017895:Manganese Compounds; D020149:Manganese Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D050050:Protein Carbonylation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects
chemical_list: D002712:Chlorides; D016166:Free Radical Scavengers; D017895:Manganese Compounds; D018696:Neuroprotective Agents; D042967:Electron Transport Complex I; C025340:manganese chloride; D000077553:Edaravone; D000983:Antipyrine
keywords: Edaravone; Magnetic resonance imaging; Manganese; Neurotoxicity; Oxidative Stress