title: Association Between Random Measured Glucose Levels in Middle and Old Age and Risk of Dementia-Related Death.
abstract: OBJECTIVE
  To investigate the association between random measured glucose levels in middle and old age and dementia-related death.
  
  
  METHODS
  Population-based cohort study.
  
  
  METHODS
  Norwegian Counties Study (middle-aged individuals; 35-49) and Cohort of Norway participants (older individuals; 65-80).
  
  
  METHODS
  Individuals without (n=74,630) and with (n=3,095) known diabetes mellitus (N=77,725); 67,865 without and 2,341 with diabetes mellitus were included in the complete case analyses (nonmissing for all included covariates), of whom 1,580 without and 131 with diabetes mellitus died from dementia-related causes.
  
  
  METHODS
  Dementia-related death was ascertained according to the Norwegian Cause of Death Registry. Cox regression was used to assess the relationship between random glucose levels (nonfasting) in individuals without and with diabetes mellitus and dementia-related death. Education, smoking, cardiovascular disease, body mass index, cholesterol, blood pressure, and physical activity were adjusted for.
  
  
  RESULTS
  Individuals without diabetes mellitus at midlife with glucose levels between 6.5 and 11.0 mmol/L had a significantly greater risk of dementia-related death than those with levels less than 5.1 mmol/L (hazard ratio=1.32, 95% confidence interval=1.04-1.67) in a fully adjusted model. A dose-response relationship (P=.02) was observed. No significant association between high glucose levels in individuals aged 65 to 80 and dementia-related death was detected.
  
  
  CONCLUSIONS
  High random glucose levels measured in middle-aged but not older age persons without known diabetes mellitus were associated with greater risk of dementia-related death up to four decades later.
authors.affiliation: Institute of Health and Society, University of Oslo, Oslo, Norway.
authors.forename: Tor Atle
authors.initials: TA
authors.lastname: Rosness
authors.affiliation: Norwegian Advisory Unit for Aging and Health, Vestfold Health Trust, Toensberg, Norway.
authors.forename: Knut
authors.initials: K
authors.lastname: Engedal
authors.affiliation: Institute of Health and Society, University of Oslo, Oslo, Norway.
authors.forename: Espen
authors.initials: E
authors.lastname: Bjertness
authors.affiliation: Institute of Health and Society, University of Oslo, Oslo, Norway.|Department of Health Statistics, Norwegian Institute of Public Health, Oslo, Norway.
authors.forename: Bjørn Heine
authors.initials: BH
authors.lastname: Strand
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002423:Cause of Death; D015331:Cohort Studies; D003704:Dementia / Q000097:blood / Q000150:complications / Q000401:mortality; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D012042:Registries; D012307:Risk Factors; D013223:Statistics as Topic; D016019:Survival Analysis; D013995:Time
chemical_list: D001786:Blood Glucose
keywords: dementia; diabetes mellitus; glucose; risk factor