title: Inhibitor of growth-4 is a potential target for cancer therapy.
abstract: The inhibitor of growth-4 (ING-4) belongs to the inhibitor of growth (ING) family that is a type II tumor suppressor gene including five members (ING1-5). As a tumor suppressor, ING4 inhibits tumor growth, invasion, and metastasis by multiple signaling pathways. In addition to that, ING4 can facilitate cancer cell sensitivity to chemotherapy and radiotherapy. Although ING4 loss is observed for many types of cancers, increasing evidences show that ING4 can be used for gene therapy. In this review, the recent progress of ING4 regulating tumorigenesis is discussed.
authors.affiliation: Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou, 212017, People's Republic of China.|Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, People's Republic of China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou, 212017, People's Republic of China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Jin
authors.affiliation: Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, People's Republic of China. sjj@ujs.edu.cn.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou, 212017, People's Republic of China. houyz@ujs.edu.cn.|Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, People's Republic of China. houyz@ujs.edu.cn.
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Hou
mesh_terms: D017209:Apoptosis / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000627:therapeutic use; D049109:Cell Proliferation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D015316:Genetic Therapy; D018398:Homeodomain Proteins / Q000235:genetics* / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000627:therapeutic use
chemical_list: D018797:Cell Cycle Proteins; D018398:Homeodomain Proteins; C483230:ING4 protein, human; D025521:Tumor Suppressor Proteins
keywords: Cell proliferation; DNA repair; ING4; NFκB; p53