title: [Oophorectomy for Ovarian Metastasis Occurring during Chemotherapy in Gastric Cancer Patients with Peritoneal Dissemination--Report of Three Cases].
abstract: We report 3 cases of advanced gastric cancer with peritoneal dissemination (PD) who underwent oophorectomy for ovarian metastases that occurred during chemotherapy. Case 1: The patient was a 43-year-old woman who had type 4 advanced gastric cancer with PD. After 24 courses of S-1 plus IV and IP paclitaxel (PTX) combination therapy, oophorectomy was performed for a rapidly growing left ovarian metastasis. Thirty-four months after the start of therapy, she has completed 44 courses of S-1 plus IV and IP PTX therapy and she is continuing the treatment. Case 2: The patient was a 77-year-old woman who underwent total gastrectomy with D2-#10 lymph node dissection and cholecystectomy for gastric cancer with PD. Right ovarian resection was performed for an ovarian metastasis 30 months after gastrectomy. She continues receiving chemotherapy 8 months after oophorectomy. Case 3: The patient was a 42-year-old woman who received S-1 plus CDDP combination therapy and 22 courses of S-1 plus IV and IP PTX for gastric cancer with PD, and oophorectomy for bilateral ovarian metastases was performed. After 10 courses of S-1 plus IV and IP PTX therapy, she died of cancer. We discuss the significance of oophorectomy during chemotherapy for advanced gastric cancer with PD.
authors.affiliation: Dept. of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases.
authors.forename: Momoko
authors.initials: M
authors.lastname: Ichihara
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Omori
authors.forename: Norikatsu
authors.initials: N
authors.lastname: Miyoshi
authors.forename: Keijiro
authors.initials: K
authors.lastname: Sugimura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Akita
authors.forename: Masaaki
authors.initials: M
authors.lastname: Motoori
authors.forename: Kunihito
authors.initials: K
authors.lastname: Gotoh
authors.forename: Hidenori
authors.initials: H
authors.lastname: Takahashi
authors.forename: Shogo
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Shingo
authors.initials: S
authors.lastname: Noura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyata
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohue
authors.forename: Masato
authors.initials: M
authors.lastname: Sakon
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yano
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005743:Gastrectomy; D006801:Humans; D010051:Ovarian Neoplasms / Q000556:secondary / Q000601:surgery*; D010052:Ovariectomy; D010534:Peritoneal Neoplasms / Q000556:secondary*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery