title: Chronic kidney disease hotspots in developing countries in South Asia.
abstract: In many developing countries in the South Asian region, screening for chronic diseases in the community has shown a widely varying prevalence. However, certain geographical regions have shown a high prevalence of chronic kidney disease (CKD) of unknown etiology. This predominantly affects the young and middle-aged population with a lower socioeconomic status. Here, we describe the hotspots of CKD of undiagnosed etiology in South Asian countries including the North, Central and Eastern provinces of Sri Lanka and the coastal region of the state of Andhra Pradesh in India. Screening of these populations has revealed cases of CKD in various stages. Race has also been shown to be a factor, with a much lower prevalence of CKD in whites compared to Asians, which could be related to the known influence of ethnicity on CKD development as well as environmental factors. The difference between developed and developing nations is most stark in the realm of healthcare, which translates into CKD hotspots in many regions of South Asian countries. Additionally, the burden of CKD stage G5 remains unknown due to the lack of registry reports, poor access to healthcare and lack of an organized chronic disease management program. The population receiving various forms of renal replacement therapy has dramatically increased in the last decade due to better access to point of care, despite the disproportionate increase in nephrology manpower. In this article we will discuss the nephrology care provided in various countries in South Asia, including India, Bangladesh, Pakistan, Nepal, Bhutan, Sri Lanka and Afghanistan.
authors.affiliation: Madras Medical Mission & Pondicherry Institute of Medical Science , Puducherry , India.
authors.forename: Georgi
authors.initials: G
authors.lastname: Abraham
authors.affiliation: Christian Medical College , Vellore , India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Varughese
authors.affiliation: Tides IHMS , Chennai , India.
authors.forename: Thiagarajan
authors.initials: T
authors.lastname: Thandavan
authors.affiliation: St. Johns Medical College , Bengaluru , India.
authors.forename: Arpana
authors.initials: A
authors.lastname: Iyengar
authors.affiliation: Stanley Medical College , Chennai , India.
authors.forename: Edwin
authors.initials: E
authors.lastname: Fernando
authors.affiliation: The Kidney Foundation , Karachi , Pakistan.
authors.forename: S A Jaffar
authors.initials: SA
authors.lastname: Naqvi
authors.affiliation: University of Colombo , Colombo , Sri Lanka.
authors.forename: Rezvi
authors.initials: R
authors.lastname: Sheriff
authors.affiliation: Kidney Foundation Hospital and Research Institute , Dhaka , Bangladesh.
authors.forename: Harun
authors.initials: H
authors.lastname: Ur-Rashid
authors.affiliation: Madras Medical College , Chennai , India.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Gopalakrishnan
authors.affiliation: National Kidney Center , Kathmandu , Nepal.
authors.forename: Rishi Kumar
authors.initials: RK
authors.lastname: Kafle
keywords: CKD; diabetes mellitus; glomerulonephritis; glomerulosclerosis; pediatrics