title: Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer.
abstract: Prostate cancer is a common cancer in men. Genetic variations in inflammatory response genes can potentially influence the risk of prostate cancer. We aimed to examine the association between PPARG Pro12Ala, NFKB1 -94 ins/del, NFKBIA -826C/T, COX-1 (50C>T), and COX-2 (-1195G>A) polymorphisms on prostate cancer risk. The genotypes of the polymorphisms were ascertained in 543 prostate cancer patients and 753 controls through PCR-RFLP and the risk association was evaluated statistically using logistic regression analysis. The NFKB1 -94 polymorphism was shown to decrease prostate cancer risk in both heterozygous and homozygous comparison models (odds ratios of 0.74 (95% CI = 0.58-0.96) (P = 0.02) and 0.57 (95% CI = 0.42-0.78) (P < 0.01), resp.). An opposite finding was observed for COX-2 (-1195) polymorphism (odds ratios of 1.58 (95% CI = 1.15-2.18) (P < 0.01) for heterozygous comparison model and 2.08 (95% CI = 1.48-2.92) (P < 0.01) for homozygous comparison model). No association was observed for other polymorphisms. In conclusion, NFKB1 -94 ins/del and COX-2 (-1195G>A) polymorphisms may be, respectively, associated with decreased and increased prostate cancer risk in the Chinese population.
authors.affiliation: Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Cui
authors.affiliation: Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Tong-Wen
authors.initials: TW
authors.lastname: Ou
authors.affiliation: Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Chun-Song
authors.initials: CS
authors.lastname: Jia
authors.affiliation: Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Xu
mesh_terms: D051545:Cyclooxygenase 1 / Q000235:genetics; D051546:Cyclooxygenase 2 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020672:I-kappa B Proteins / Q000235:genetics; D008297:Male; D000072000:NF-KappaB Inhibitor alpha; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors
chemical_list: D020672:I-kappa B Proteins; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; C000606204:NFKBIA protein, human; D047495:PPAR gamma; D000072000:NF-KappaB Inhibitor alpha; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human