title: Degradation and transformation of 17α-trenbolone in aerobic water-sediment systems.
abstract: Synovex® ONE is an extended-release implant containing the active ingredients estradiol benzoate and trenbolone acetate for use in beef steers and heifers. Trenbolone acetate is rapidly hydrolyzed in cattle to form 17β-trenbolone and its isomer, 17α-trenbolone, which are further transformed to a secondary metabolite, trendione. As part of the environmental assessment for the use of Synovex ONE, data were generated to characterize the fate of 17α-trenbolone, which is the principal metabolite found in cattle excreta, in the environment. A study was conducted to determine the degradation and transformation of [14C]-17α-trenbolone in 2 representative water-sediment systems under aerobic conditions. The same transformation products, 17β-trenbolone and trendione, were formed, principally in the sediment phase, in both systems. From the production of these transformation products, the 50% disappearance time (DT50) values of 17β-trenbolone and trendione were determined, along with the DT50 values of the parent compound and the total drug (17α-trenbolone + 17β-trenbolone + trendione). The DT50 values for the total system (aqueous and sediment phase) and for the total residues (17α-trenbolone + 17β-trenbolone + trendione) in the 2 systems were 34.7 d and 53.3 d, respectively. Environ Toxicol Chem 2017;36:630-635. © 2016 SETAC.
authors.affiliation: Zoetis, Kalamazoo, Michigan, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Robinson
authors.affiliation: Exponent, Washington, DC, USA.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Exponent, Cary, North Carolina, USA.
authors.forename: Jane P
authors.initials: JP
authors.lastname: Staveley
authors.affiliation: Phase II+, Kalamazoo, Michigan, USA.
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Smolenski
authors.affiliation: Pfizer, Worldwide R&D, PDM-Environmental Sciences, Groton, Connecticut, USA.
authors.forename: Jon
authors.initials: J
authors.lastname: Ericson
mesh_terms: D000332:Aerobiosis; D045930:Anabolic Agents / Q000032:analysis / Q000378:metabolism; D000818:Animals; D001673:Biodegradation, Environmental; D002417:Cattle; D004784:Environmental Monitoring / Q000379:methods*; D004958:Estradiol / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D004963:Estrenes / Q000032:analysis* / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005260:Female; D019015:Geologic Sediments / Q000737:chemistry*; D008372:Manure / Q000032:analysis; D045483:Rivers / Q000737:chemistry*; D014204:Trenbolone Acetate / Q000032:analysis* / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000378:metabolism
chemical_list: D045930:Anabolic Agents; D004963:Estrenes; D008372:Manure; D014874:Water Pollutants, Chemical; C074283:estradiol 3-benzoate; C070427:trendione; D004958:Estradiol; D014204:Trenbolone Acetate
keywords: Androgenic compound; Steroid transformation; Synovex® ONE; Trenbolone; Veterinary medicine