title: Low expression of long noncoding RNA CASC2 indicates a poor prognosis and regulates cell proliferation in non-small cell lung cancer.
abstract: Recently, long noncoding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancer biology. The aim of this study was to evaluate the expression and biological role of lncRNA CASC2 in non-small cell lung cancer (NSCLC). By bioinformatics analysis, we found that CASC2 was significantly decreased in NSCLC. qRT-PCR was performed to investigate the expression of CASC2 in tumor tissues and corresponding non-tumor NSCLC tissues from 76 patients. The lower expression of CASC2 was remarkably correlated with advanced TNM stage and tumor size. Multivariate analyses found that CASC2 expression served as an independent predictor for overall survival of NSCLC. Moreover, overexpression of CASC2 significantly inhibited NSCLC cell proliferation both in vitro and in vivo. In conclusion, our study demonstrated that CASC2 is involved in the development and progression of NSCLC and shows that CASC2 may be a potential diagnostic and target for new therapies in patients with NSCLC.
authors.affiliation: Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: Xuezhi
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Oncology, the Affiliated Jiangyin hospital, School of Medicien, Southeast University, Wuxi, Jiangsu, People's Republic of China.
authors.forename: Zhili
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Oncology, the Affiliated Jiangyin hospital, School of Medicien, Southeast University, Wuxi, Jiangsu, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Yang
authors.affiliation: Central laboratory, the Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Yin
authors.affiliation: Department of Oncology, Xuzhou Central Hospital, Affiliated Xuzhou Hospital, College of Medicine, Southeast University, Xuzhou, Jiangsu, People's Republic of China. lianghan_xuzhou@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China. dewei@njmu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: De
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China. renhuaguo2014@sina.com.
authors.forename: Renhua
authors.initials: R
authors.lastname: Guo
mesh_terms: D000072283:A549 Cells; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding; D025521:Tumor Suppressor Proteins; C484713:long non-coding RNA CASC2, human
keywords: CASC2; Cell proliferation; NSCLC; lncRNAs