title: A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms.
abstract: We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.
authors.affiliation: Centre Universitaire d׳Informatique, Université de Genève, 7, route de Drize, CH-1227 Switzerland. Electronic address: orestis.malaspinas@unige.ch.
authors.forename: O
authors.initials: O
authors.lastname: Malaspinas
authors.affiliation: Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women׳s Hospital and Harvard Medical School, Boston, MA 02115, United States; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Boston MA 02139, United States.
authors.forename: A
authors.initials: A
authors.lastname: Turjman
authors.affiliation: Laboratoire de Médecine Expérimentale (ULB 222 Unit), Université Libre de Bruxelles, CHU de Charleroi, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Ribeiro de Sousa
authors.affiliation: Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women׳s Hospital and Harvard Medical School, Boston, MA 02115, United States.
authors.forename: G
authors.initials: G
authors.lastname: Garcia-Cardena
authors.affiliation: Unit of Biochemistry and Cellular Biology (URBC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur (UNamur), 61 Rue de Bruxelles, B-5000 Namur, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Raes
authors.affiliation: Centre Universitaire d׳Informatique, Université de Genève, 7, route de Drize, CH-1227 Switzerland.
authors.forename: P-T T
authors.initials: PT
authors.lastname: Nguyen
authors.affiliation: CREATIS INSA-Lyon, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: CREATIS INSA-Lyon, France.
authors.forename: G
authors.initials: G
authors.lastname: Courbebaisse
authors.affiliation: Laboratoire de Médecine Expérimentale (ULB 222 Unit), Université Libre de Bruxelles, CHU de Charleroi, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Lelubre
authors.affiliation: Laboratoire de Médecine Expérimentale (ULB 222 Unit), Université Libre de Bruxelles, CHU de Charleroi, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Zouaoui Boudjeltia
authors.affiliation: Centre Universitaire d׳Informatique, Université de Genève, 7, route de Drize, CH-1227 Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Chopard
mesh_terms: D003198:Computer Simulation; D018056:Hemorheology; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D008954:Models, Biological; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D062211:Spatio-Temporal Analysis; D013314:Stress, Mechanical; D013927:Thrombosis / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology
chemical_list: D012333:RNA, Messenger
keywords: Blood-flow; Cerebral aneurysm; Clotting; Lattice Boltzmann; Numerical modelling; Thrombosis