title: Sensing Conductive Hydrogels for Rapid Detection of Cytokines in Blood.
abstract: Conducting polymer hydrogel is fabricated atop gold or ITO electrodes and is functionalized with monoclonal antibodies. Binding of interferon-γ molecules causes redox properties of conductive hydrogel to change in a concentration-dependent fashion without the need for washing or sample handling steps. This conductive hydrogel remains functional in a fouling media such as whole blood.
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.|Department of Medical & Pharmaceutical Sciences, Sookmyung Women's University, Seoul, 140-742, Republic of Korea.
authors.forename: Dong-Sik
authors.initials: DS
authors.lastname: Shin
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.|Department of Electrical and Computer Engineering, University of California, Davis, CA, 95616, USA.
authors.forename: Zimple
authors.initials: Z
authors.lastname: Matharu
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.|Department of Plant & Environmental New Resources, Kyung Hee University, Yongin, 446-701, Republic of Korea.
authors.forename: Jungmok
authors.initials: J
authors.lastname: You
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Siltanen
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.
authors.forename: Tam
authors.initials: T
authors.lastname: Vu
authors.affiliation: Department of Surgical & Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
authors.forename: Vijay Krishna
authors.initials: VK
authors.lastname: Raghunathan
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.
authors.forename: Gulnaz
authors.initials: G
authors.lastname: Stybayeva
authors.affiliation: California Animal Health and Food Safety Laboratory, University of California, Davis, CA, 95616, USA.
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Hill
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Revzin
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D002417:Cattle; D016207:Cytokines / Q000097:blood*; D055664:Electrochemical Techniques; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D007371:Interferon-gamma / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D016207:Cytokines; D020100:Hydrogels; D011108:Polymers; D017971:Tin Compounds; C121383:poly(3,4-ethylene dioxythiophene); C109984:indium tin oxide; D006046:Gold; D007371:Interferon-gamma
keywords: biosensors; conducting polymer hydrogels; cytokine detection; electrochemical detection; immunoassays