title: [Treatment of Chronic Heart Failure with Carotid Plaque Patients by Yiqi Huoxue Tongyang Xezhuo Recipe].
abstract: OBJECTIVE
  To evaluate the clinical effectiveness of Yiqi Huoxue Tongyang Xiezhuo Recipe (YHTXR, capable of supplementing qi, activating blood, warming yang, and discharge turbidity) in treating coronary atherosclerotic heart disease (CAHD). and chronic heart failure (CHF) with carotid plaque patients, and to explore new ways of Chinese medicine (CM).
  
  
  METHODS
  Totally 69 CAHD-CHF patients of qi deficiency phlegm stasis syndrome (QDPSS) with carotid plaque were recruited in this study using parallel cohort method. They were assigned to the treatment group (35 cases) and the control group (34 cases). Patients in the control group received routine treatment of Western medicine, while those in the treatment group were additionally treated with YHTXR (twice daily). The therapeutic course for all was three months. Cardiac function levels, echocardiography, carotid plaque, blood lipids and safety indicators were observed before and after treatment.
  
  
  RESULTS
  After treatment the improvement of cardiac function levels was better in the treatment group than in the control group (P < 0.05). Decreased LDL-C levels were higher in the treatment group than in the control group (P < 0.01). There was statistical difference in left ventricular ejection fraction (LVEF), carotid intima-media thickness (IMT), LDL-C, TC, TG in the treatment group between before and after treatment (P < 0.05). LDL-C and TG also decreased in the control group after treatment (P <0.05). There was no significant difference in the left ventricular ejection fraction, carotid IMT, or TC in the control group between before and after treatment (P > 0.05). There was no significant difference in stroke volume, left ventricular end-diastolic diameter, the area of carotid artery plaque, or HDL-C in the two groups between before and after treatment (P > 0.05).
  
  
  CONCLUSIONS
  YHTXR could effectively improve cardiac functions of CAHD-CHF patients of QDPSS with carotid plaque, reduce blood lipids and IMT. It had no significant adverse reactions for elderly patients in short term.
authors.forename: Wen-ting
authors.initials: WT
authors.lastname: Du
authors.forename: Guan
authors.initials: G
authors.lastname: Ming
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Jing-yi
authors.initials: JY
authors.lastname: Tang
authors.forename: Bing
authors.initials: B
authors.lastname: Deng
authors.forename: Nuo
authors.initials: N
authors.lastname: Tang
mesh_terms: D059168:Carotid Intima-Media Thickness; D003327:Coronary Disease; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006321:Heart; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008055:Lipids; D058226:Plaque, Atherosclerotic / Q000188:drug therapy*; D019413:Qi; D016277:Ventricular Function, Left
chemical_list: D004365:Drugs, Chinese Herbal; D008055:Lipids; C033946:yiki-huoxue