title: A highly fluorescent AIE-active theranostic agent with anti-tumor activity to specific cancer cells.
abstract: A tetraphenylethene derivative with a structure resembling Tamoxifen is designed and synthesized as a theranostic agent for cell imaging and anti-breast cancer therapy. Its high brightness, excellent photostability and long-term cell tracing properties enable elucidation of its working mechanism and hence provide new insights into drug development.
authors.affiliation: HKUST Shenzhen Research Institute, No. 9 Yuexing 1st Road, South Area, Hi-tech Park, Nanshan, Shenzhen 518057, China. tangbenz@ust.hk.
authors.forename: Yueyue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ryan T K
authors.initials: RT
authors.lastname: Kwok
authors.forename: Jacky W Y
authors.initials: JW
authors.lastname: Lam
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D005456:Fluorescent Dyes; D006801:Humans; D061986:MCF-7 Cells; D013267:Stilbenes / Q000494:pharmacology; D013629:Tamoxifen / Q000494:pharmacology; D000068936:Theranostic Nanomedicine
chemical_list: D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D013267:Stilbenes; C000617116:tetraphenylethylene; D013629:Tamoxifen