title: A Langevin model of physical forces in cell volume fluctuations.
abstract: Cells interact mechanically with their physical surroundings by attaching to the extracellular matrix or other cells and contracting the cytoskeleton. Cells do so dynamically, exhibiting fluctuating contractile motion in time. In monolayers, these dynamic contractions manifest as volume fluctuations, which involve the transport of fluid in and out of the cell. An integrated understanding of cell elasticity, actively generated stresses, and fluid transport has not yet been developed. Here we apply a minimal model of these forces to cell volume fluctuation data, elucidating the dynamic behavior of cells within monolayers.
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Zehnder
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, USA; Department of Mathematics, University of Florida, Gainesville, USA.
authors.forename: Federico M
authors.initials: FM
authors.lastname: Zegers
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, USA; Institute of Cell and Regenerative Medicine, University of Florida, Gainesville, USA. Electronic address: t.e.angelini@ufl.edu.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Angelini
mesh_terms: D000818:Animals; D048429:Cell Size; D003599:Cytoskeleton / Q000502:physiology; D004285:Dogs; D004548:Elasticity; D061985:Madin Darby Canine Kidney Cells; D008954:Models, Biological
keywords: Cell; Cell mechanics; Cytoskeleton; Langevin model; Traction force microscopy; Volume