title: Canine Cutaneous and Subcutaneous Soft Tissue Sarcoma: An Evidence-Based Review of Case Management.
abstract: Canine cutaneous and subcutaneous soft tissue sarcomas (STS) account for 20.3% of malignant neoplasms of the skin. This article makes recommendations for the diagnosis, treatment, and follow-up in dogs with STS, using evidence-based medicine concepts. Although our review of the literature on the management of canine STS found many of the studies to be less than rigorous, board-certified specialists in internal medicine, surgery, pathology, oncology, and radiation oncology were able to make several recommendations based on the literature review: cytology and biopsy are important for presurgical planning; wide (>3 cm margins) surgical excision decreases the likelihood of tumor recurrence; the use of a histologic grading scale is useful in predicting biologic behavior; and, in select cases, chemotherapy and radiation therapy may be beneficial adjunct treatments to surgical excision. More research is necessary to determine minimum size of surgical margins, the impact of radiation therapy on incompletely resected tumors, the ideal chemotherapy protocol for high grade STS, and the optimal methods of monitoring dogs for tumor recurrence and metastasis.
authors.affiliation: From the Animal Medical Center, New York, NY (A.E.H.); Stanford University, Stanford, CA (J.L.K.); IDEXX Laboratories, New York, NY (J.H.); Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA (L.B.); VCA Veterinary Referral and Emergency Center, Norwalk, CT (M.P.); the Veterinary Cancer Center, Norwalk, CT (J.F.); and Guilford Veterinary Hospital, Guilford, CT (A.S.).
authors.forename: Ann E
authors.initials: AE
authors.lastname: Hohenhaus
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Kelsey
authors.affiliation: From the Animal Medical Center, New York, NY (A.E.H.); Stanford University, Stanford, CA (J.L.K.); IDEXX Laboratories, New York, NY (J.H.); Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA (L.B.); VCA Veterinary Referral and Emergency Center, Norwalk, CT (M.P.); the Veterinary Cancer Center, Norwalk, CT (J.F.); and Guilford Veterinary Hospital, Guilford, CT (A.S.).
authors.forename: Jamie
authors.initials: J
authors.lastname: Haddad
authors.affiliation: From the Animal Medical Center, New York, NY (A.E.H.); Stanford University, Stanford, CA (J.L.K.); IDEXX Laboratories, New York, NY (J.H.); Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA (L.B.); VCA Veterinary Referral and Emergency Center, Norwalk, CT (M.P.); the Veterinary Cancer Center, Norwalk, CT (J.F.); and Guilford Veterinary Hospital, Guilford, CT (A.S.).
authors.forename: Lisa
authors.initials: L
authors.lastname: Barber
authors.affiliation: From the Animal Medical Center, New York, NY (A.E.H.); Stanford University, Stanford, CA (J.L.K.); IDEXX Laboratories, New York, NY (J.H.); Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA (L.B.); VCA Veterinary Referral and Emergency Center, Norwalk, CT (M.P.); the Veterinary Cancer Center, Norwalk, CT (J.F.); and Guilford Veterinary Hospital, Guilford, CT (A.S.).
authors.forename: Matthew
authors.initials: M
authors.lastname: Palmisano
authors.affiliation: From the Animal Medical Center, New York, NY (A.E.H.); Stanford University, Stanford, CA (J.L.K.); IDEXX Laboratories, New York, NY (J.H.); Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA (L.B.); VCA Veterinary Referral and Emergency Center, Norwalk, CT (M.P.); the Veterinary Cancer Center, Norwalk, CT (J.F.); and Guilford Veterinary Hospital, Guilford, CT (A.S.).
authors.forename: John
authors.initials: J
authors.lastname: Farrelly
authors.affiliation: From the Animal Medical Center, New York, NY (A.E.H.); Stanford University, Stanford, CA (J.L.K.); IDEXX Laboratories, New York, NY (J.H.); Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA (L.B.); VCA Veterinary Referral and Emergency Center, Norwalk, CT (M.P.); the Veterinary Cancer Center, Norwalk, CT (J.F.); and Guilford Veterinary Hospital, Guilford, CT (A.S.).
authors.forename: Anita
authors.initials: A
authors.lastname: Soucy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D019317:Evidence-Based Medicine; D012509:Sarcoma / Q000628:therapy / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000628:therapy / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents