title: A Randomized Controlled Trial to Compare the Safety and Efficacy of Tadalafil and Tamsulosin in Relieving Double J Stent Related Symptoms.
abstract: Objectives. To evaluate the safety and efficacy of Tadalafil and Tamsulosin in treating Double J stent related symptoms. Methods. In a prospective study, 161 patients with DJ related symptoms were randomized into 3 groups: Group A patients (54), Group B patients (53), and Group C patients (54). They were given Tadalafil, Tamsulosin, and placebo, respectively, at 1st week till removal of DJ stent at 3rd week. All patients completed Ureteral Stent Symptom Questionnaire (USSQ) at 1st week and at 3rd week. The statistical significant difference among groups was determined by the t-test, Kruskal-Wallis test and multivariate analysis were used to assess association of the variables within the three groups, and the level of significance was set at P < 0.05. Results. Tadalafil and Tamsulosin were comparable in relieving urinary symptoms, general health, and work performance (OR = 0.65, 1.8, and 0.92). But Tadalafil was more effective in relieving body pain, sexual problems, and additional problems than Tamsulosin (OR = 5.95, 19.25, and 2.69) and was statistically significant as P < 0.05. Conclusion. Tadalafil was as effective as Tamsulosin in relieving urinary symptom but more effective in relieving sexual symptoms and body pain.
authors.affiliation: SMS Medical College and Hospital, Jaipur 302004, India.
authors.forename: Satinder Pal
authors.initials: SP
authors.lastname: Aggarwal
authors.affiliation: SMS Medical College and Hospital, Jaipur 302004, India.
authors.forename: Shivam
authors.initials: S
authors.lastname: Priyadarshi
authors.affiliation: SMS Medical College and Hospital, Jaipur 302004, India.
authors.forename: Vinay
authors.initials: V
authors.lastname: Tomar
authors.affiliation: SMS Medical College and Hospital, Jaipur 302004, India.
authors.forename: S S
authors.initials: SS
authors.lastname: Yadav
authors.affiliation: SMS Medical College and Hospital, Jaipur 302004, India.
authors.forename: Goto
authors.initials: G
authors.lastname: Gangkak
authors.affiliation: SMS Medical College and Hospital, Jaipur 302004, India.
authors.forename: Nachiket
authors.initials: N
authors.lastname: Vyas
authors.affiliation: SMS Medical College and Hospital, Jaipur 302004, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Agarwal
authors.affiliation: SMS Medical College and Hospital, Jaipur 302004, India.
authors.forename: Ujwal
authors.initials: U
authors.lastname: Kumar