title: Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules.
abstract: Adipogenesis is the process by which precursor stem cells differentiate into lipid laden adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene expression program. In mammalian cells, the peroxisome proliferator-activated receptor γ (PPARγ), and the CCAAT/enhancer binding proteins (C/EBPs) such as C/EBPα, β and δ are considered the key early regulators of adipogenesis, while fatty acid binding protein 4 (FABP4), adiponectin, and fatty acid synthase (FAS) are responsible for the formation of mature adipocytes. Excess accumulation of lipids in the adipose tissue leads to obesity, which is associated with cardiovascular diseases, type II diabetes and other pathologies. Thus, investigating adipose tissue development and the underlying molecular mechanisms is vital to develop therapeutic agents capable of curbing the increasing incidence of obesity and related pathologies. In this review, we address the process of adipogenic differentiation, key transcription factors and proteins involved, adipogenic regulators and potential anti-adipogenic bioactive molecules.
authors.affiliation: Department of Animal Science, University of Manitoba, 201 Animal Science building, Winnipeg, MB R3T 2N2, Canada. mosetidorothy@gmail.com.
authors.forename: Dorothy
authors.initials: D
authors.lastname: Moseti
authors.affiliation: Department of Animal Science, University of Manitoba, 201 Animal Science building, Winnipeg, MB R3T 2N2, Canada. aregassa2005@gmail.com.
authors.forename: Alemu
authors.initials: A
authors.lastname: Regassa
authors.affiliation: Department of Poultry Science, University of Georgia, 303 Poultry Science Building, Athens, GA 30602-2772, USA. wkkim@uga.edu.
authors.forename: Woo-Kyun
authors.initials: WK
authors.lastname: Kim
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D050156:Adipogenesis / Q000187:drug effects* / Q000235:genetics; D052242:Adiponectin / Q000235:genetics / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000818:Animals; D051743:CCAAT-Enhancer-Binding Protein-delta / Q000235:genetics / Q000378:metabolism; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics / Q000378:metabolism; D054890:Fatty Acid Synthase, Type I / Q000235:genetics / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D019833:Genistein / Q000627:therapeutic use*; D006801:Humans; D006888:Hydroxycholesterols / Q000627:therapeutic use*; D051379:Mice; D009765:Obesity / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D000077185:Resveratrol; D015398:Signal Transduction; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human; C497252:CEBPD protein, human; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D006888:Hydroxycholesterols; D047495:PPAR gamma; D020033:Protein Isoforms; D013267:Stilbenes; D051743:CCAAT-Enhancer-Binding Protein-delta; D019833:Genistein; C518729:FASN protein, human; D054890:Fatty Acid Synthase, Type I; D000077185:Resveratrol
keywords: C/EBPα; PPARγ; adipogenesis; adipose tissue; obesity