title: Ultrasound7 versus ultrasound12 in monitoring the response to infliximab in patients with rheumatoid arthritis.
abstract: This study aimed to assess the responsiveness of ultrasonography (US)-7 in patients with rheumatoid arthritis (RA). Eighty-two RA patients were recruited and followed up for 22 weeks. The clinical, laboratory, and X-ray assessments, along with grayscale US (GSUS) and power Doppler US (PDUS) examinations were performed at baseline, 6, 14, and 22 weeks after infliximab treatment. GSUS for synovitis and PDUS for synovitis and paratendinitis/tenosynovitis were assessed by a semi-quantitative (0 to 3) score, while GSUS for paratendinitis/tenosynovitis and bone erosion was qualitatively assessed as absent or present (0 or 1). US scores in both 7-joint (US7) and 12-joint (US12) systems were evaluated. After 6, 14, and 22 weeks of treatment with infliximab, indices such as US scores, 28-joint disease activity (DAS28) score, and tender and swelling joint count were all significantly improved compared to baseline. US7 scores were significantly correlated with that of US12. Strong correlations were identified between most US7 scores with DAS28, health assessment questionnaire (HAQ), and C-reactive protein (CRP) levels. When DAS28 was used as a reference, the US7 cutoff for disease remission was less than 35 for GS + PD and also less than 29 for GS and 1 for PD, respectively. Additionally, the positive percent agreement, negative percent agreement, and overall percent agreement for GS + PD were 77.78, 76.19, and 76.67 %, respectively, which were all higher than that of GS or PD. US7 may be a feasible tool to assess the therapeutic response in RA patients.
authors.affiliation: Department of Rheumatology, Peking Union Medical College Hospital (West Campus), Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Leng
authors.affiliation: The First Hospital of China Medical University, Shenyang, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Rheumatology, Peking Union Medical College Hospital (West Campus), Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, China.
authors.forename: Zhonghui
authors.initials: Z
authors.lastname: Xu
authors.affiliation: The First Hospital of Wenzhou Medical College, Wenzhou, China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Changhai Hospital of Shanghai, Shanghai, China.
authors.forename: Dongbao
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Shanghai Changzheng Hospital, Shanghai, China.
authors.forename: Huji
authors.initials: H
authors.lastname: Xu
authors.affiliation: The First People's Hospital of Foshan, Foshan, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Rheumatology, Peking Union Medical College Hospital (West Campus), Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.affiliation: The First Hospital of China Medical University, Shenyang, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: The First Hospital of China Medical University, Shenyang, China.
authors.forename: Jiakai
authors.initials: J
authors.lastname: Wang
authors.affiliation: The First Hospital of Wenzhou Medical College, Wenzhou, China.
authors.forename: Xiaoru
authors.initials: X
authors.lastname: Xia
authors.affiliation: The First Hospital of Wenzhou Medical College, Wenzhou, China.
authors.forename: Yongji
authors.initials: Y
authors.lastname: Li
authors.affiliation: West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Honghu
authors.initials: H
authors.lastname: Tang
authors.affiliation: Changhai Hospital of Shanghai, Shanghai, China.
authors.forename: Yeqing
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Shanghai Changzheng Hospital, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Bao
authors.affiliation: Shanghai Changzheng Hospital, Shanghai, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Shanghai Changzheng Hospital, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: Shanghai Changzheng Hospital, Shanghai, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.affiliation: The First People's Hospital of Foshan, Foshan, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology, Peking Union Medical College Hospital (West Campus), Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, China. zhaoyan_pumch2002@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005260:Female; D050823:Hand Joints / Q000000981:diagnostic imaging*; D006801:Humans; D000069285:Infliximab / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014463:Ultrasonography / Q000379:methods*; D055815:Young Adult
chemical_list: D018501:Antirheumatic Agents; D000069285:Infliximab
keywords: Anti-TNFα; Disease activity assessment; Grayscale ultrasound; Power Doppler ultrasound; Rheumatoid arthritis