title: [Negative prognostic impact of female gender on oncological outcomes following radical cystectomy].
abstract: OBJECTIVE
  To confirm gender specific differences in pathologic factors and survival rates of urothelial bladder cancer patients treated with radical cystectomy.
  
  
  METHODS
  We conducted a retrospective monocentric study on 701 patients treated with radical cystectomy and pelvic lymphadenectomy for muscle invasive bladder cancer. Impact of gender on recurrence rate, specific and non-specific mortality rate were evaluated using Cox regression models in univariate and multivariate analysis.
  
  
  RESULTS
  We collected data on 553 males (78.9%) and 148 females (21.1%) between 1998 and 2011. Both groups were comparable at inclusion regarding age, pathologic stage, nodal status and lymphovascular invasion. Mean follow-up time was 45 months (interquartile 23-73) and by that time, 163 patients (23.3%) had recurrence of their tumor and 127 (18.1%) died from their disease. In multivariable Cox regression analyses, female gender was independently associated with disease recurrence (RR: 1.73; 95% CI 1.22-2.47; P=0.02) and cancer-specific mortality (RR=2.50, 95% CI=1.71-3.68; P<0.001).
  
  
  CONCLUSIONS
  We confirmed female gender to be an independent negative prognosis factor for patients following a radical cystectomy and lymphadenectomy for an invasive muscle bladder cancer.
authors.affiliation: Service d'urologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Dabi
authors.affiliation: Service d'urologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Rouscoff
authors.affiliation: Service d'urologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: N B
authors.initials: NB
authors.lastname: Delongchamps
authors.affiliation: Service d'urologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Sibony
authors.affiliation: Service d'urologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Saighi
authors.affiliation: Service d'urologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Zerbib
authors.affiliation: Service d'urologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Peyraumore
authors.affiliation: Service d'urologie, hôpital Cochin, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. Electronic address: evanguelosxylinas@hotmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Xylinas
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015653:Cystectomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D001749:Urinary Bladder Neoplasms / Q000601:surgery*
keywords: Bladder cancer; Cancer-specific mortality; Cystectomie totale; Disease recurrence; Facteurs pronostiques; Gender; Mortalité spécifique; Prognostic factors; Radical cystectomy; Récidive; Sexe; Tumeur de vessie