title: Epigenetic mechanisms of bone regeneration and homeostasis.
abstract: Bone regeneration is a promising avenue for osteoporosis (OP) treatment. It consists of several procedures, such as the osteogenic differentiation of mesenchymal stem cells as well as the proliferation and maturation of osteoblasts. Many epigenetic mechanisms are involved in the modulation of bone regeneration, including DNA methylation, histone modifications, and microRNA regulation. These processes functionally modify the genome without changing the nucleotide sequence, leading to changes in gene expression. Past studies have identified the importance of epigenetic mechanisms in bone metabolism. In this review, we will summarize the recent studies in this field to obtain a better understanding of how epigenetic mechanisms participate in bone regeneration and homeostasis. This will provide us a new target for investigating clinical perspectives of osteoporosis treatment.
authors.affiliation: Institute of Metabolism and Endocrinology, Second Xiang-Ya Hospital, Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, PR China; Department of Endocrinology, Qilu Hospital, Shandong University, 107# West Wenhua Road, Jinan, Shandong 250012, PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Qilu Hospital, Shandong University, 107# West Wenhua Road, Jinan, Shandong 250012, PR China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Qilu Hospital, Shandong University, 107# West Wenhua Road, Jinan, Shandong 250012, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Institute of Metabolism and Endocrinology, Second Xiang-Ya Hospital, Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.affiliation: Institute of Metabolism and Endocrinology, Second Xiang-Ya Hospital, Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xiong
authors.affiliation: Institute of Metabolism and Endocrinology, Second Xiang-Ya Hospital, Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Institute of Metabolism and Endocrinology, Second Xiang-Ya Hospital, Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, PR China. Electronic address: allenylq@hotmail.com.
authors.forename: Ling-Qing
authors.initials: LQ
authors.lastname: Yuan
authors.affiliation: Institute of Metabolism and Endocrinology, Second Xiang-Ya Hospital, Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, PR China. Electronic address: eyliao@21cn.com.
authors.forename: Er-Yuan
authors.initials: EY
authors.lastname: Liao
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics
chemical_list: D006657:Histones; D035683:MicroRNAs
keywords: Bone regeneration; DNA methylation; Histone modification; MicroRNA