title: Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia.
abstract: The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety-associated symptoms. The present study assessed the effect of Citrus aurantium L. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either the C. aurantium essential oil through inhalation, diazepam (10 mg), or the placebo. The evaluation was performed through psychometric scales [State-Trait Anxiety Inventory (STAI)] and physiological measurements (blood pressure and cardiac and respiratory frequency). Inhalation of C. aurantium was associated with a decrease in the STAI-S scores, suggesting an anxiolytic effect. In support of these results, a change in all the physiological measurements was observed in the group exposed to C. aurantium. In the diazepam group, only the diastolic pressure decreased, and no effect was observed in the placebo group. Therefore, the results showed that C. aurantium exhibits an anxiolytic effect and reduces the signs and symptoms associated with anxiety in patients with CML.
authors.affiliation: Department of Medicine, Medical Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.
authors.forename: Flávia Cristina Fernandes
authors.initials: FC
authors.lastname: Pimenta
authors.affiliation: Postgraduate Program in Bioactive Natural and Synthetic Products, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Brazil.
authors.forename: Mateus Feitosa
authors.initials: MF
authors.lastname: Alves
authors.affiliation: Academic Medicine, Faculty of Medicine New Hope, Paraíba, Brazil.
authors.forename: Martina Bragante Fernandes
authors.initials: MB
authors.lastname: Pimenta
authors.affiliation: Graduate Program in Decision Models and Health, Center of Exact and Natural Sciences, Federal University of Paraíba, João Pessoa, Brazil.
authors.forename: Silvia Adelaide Linhares
authors.initials: SA
authors.lastname: Melo
authors.affiliation: Department of Speech Therapy, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Brazil.
authors.forename: Anna Alice Figueirêdo
authors.initials: AA
authors.lastname: de Almeida
authors.affiliation: Department of Psychobiology, Federal University of São Paulo, João Pessoa, Brazil.
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Leite
authors.affiliation: Department of Physiology and Pathology, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Brazil.
authors.forename: Liana Clébia de Morais
authors.initials: LC
authors.lastname: Pordeus
authors.affiliation: Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Brazil.
authors.forename: Margareth de Fátima Formiga Melo
authors.initials: Mde F
authors.lastname: Diniz
authors.affiliation: Department of Physiology and Pathology, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Brazil.
authors.forename: Reinaldo Nóbrega
authors.initials: RN
authors.lastname: de Almeida
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy*; D001794:Blood Pressure; D002957:Citrus / Q000737:chemistry*; D003975:Diazepam / Q000627:therapeutic use; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000523:psychology*; D008875:Middle Aged; D009812:Odorants; D009822:Oils, Volatile / Q000737:chemistry / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D009822:Oils, Volatile; D010936:Plant Extracts; D003975:Diazepam
keywords: Citrus aurantium L; anxiety; chronic myeloid leukemia; essential oil; via inhalation