title: ⁹⁹mTc-anti-TNF-α antibody for the imaging of disease activity in pulmonary sarcoidosis.
abstract: Infliximab, a monoclonal antibody directed against tumour necrosis factor (TNF)-α, is used in the treatment of refractory sarcoidosis. However, the clinical response is variable and a tool to select responders beforehand is highly desirable. In this study we evaluated scintigraphy with technetium-99m ((99m)Tc)-labelled infliximab for the imaging of disease activity in patients with pulmonary sarcoidosis.10 patients were studied using single photon emission computed tomography/computed tomography (CT) 6 h and 20 h after intravenous administration of 370 MBq of(99m)Tc-infliximab. Correlation analysis was performed between tissue accumulation of(99m)Tc-infliximab and laboratory parameters (including soluble interleukin-2 receptor and angiotensin-converting enzyme), lung function parameters (including forced expiratory volume in 1 s and the diffusing capacity of the lung for carbon monoxide) and(18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT.Analysis showed selective and variable accumulation of(99m)Tc-infliximab in the target tissue. Accumulation correlated positively with all four laboratory parameters and negatively with all four lung function parameters, yielding better correlations than serum TNF-α levels or(18)F-FDG PET/CT.(99m)Tc-infliximab accumulation reflects thein situTNF-α expression in an individual patient and therefore provides valuable information on the presence of the biological target for anti-TNF-α therapy.
authors.affiliation: Dept of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands r.vis@antoniusziekenhuis.nl.
authors.forename: Roeland
authors.identifier: http://orcid.org/0000-0002-4653-8549
authors.initials: R
authors.lastname: Vis
authors.affiliation: Nuclear Imaging, Cancer Research UK Beatson Institute, Glasgow, UK Dept of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Malviya
authors.affiliation: Dept of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands Nuclear Medicine Unit, Dept of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Signore
authors.affiliation: Centre of Interstitial Lung Diseases, Dept of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands Heart and Lung Division, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Jan C
authors.initials: JC
authors.lastname: Grutters
authors.affiliation: Dept of Medical Microbiology and Immunology, St Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Bob
authors.initials: B
authors.lastname: Meek
authors.affiliation: Dept of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Ewoudt M W
authors.initials: EM
authors.lastname: van de Garde
authors.affiliation: Dept of Nuclear Medicine, St Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Ruth G M
authors.initials: RG
authors.lastname: Keijsers
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry; D006801:Humans; D000069285:Infliximab / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000737:chemistry; D049268:Positron-Emission Tomography; D011877:Radionuclide Imaging; D015375:Receptors, Interleukin-2 / Q000737:chemistry; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging*; D000072098:Single Photon Emission Computed Tomography Computed Tomography; D013667:Technetium / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D019788:Fluorodeoxyglucose F18; D013667:Technetium; D000069285:Infliximab; D007703:Peptidyl-Dipeptidase A