title: [A Case of Locally Advanced Gastric Cancer after Neoadjuvant Chemotherapy].
abstract: A 60s male was admitted to our hospital because of appetite loss and nausea. After examination, he was diagnosed with type 3 advanced gastric cancer in the antrum. Abdominal computed tomography showed gastric cancer invasion to the left liver lobe. We initiated neoadjuvant chemotherapy using S-1 plus CDDP after laparoscopic gastrojejunostomy. S-1 was orally administered for 3 weeks followed by a 2-week drug-free period. CDDP was administered intravenously on day 8 of each course. After 5 courses of chemotherapy, the gastric cancer was reduced in size. We therefore performed total gastrectomy with D2-affiliated left liver resection. S-1 plus CDDP is expected to improve outcomes in unresectable or locally advanced gastric cancer.
authors.affiliation: Dept. of Surgery, Fukuoka Tokushukai Medical Center.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Okamoto
authors.forename: Keita
authors.initials: K
authors.lastname: Tanaka
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Yonemitsu
authors.forename: Taro
authors.initials: T
authors.lastname: Munechika
authors.forename: Masako
authors.initials: M
authors.lastname: Nomi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maeno
authors.forename: Shuji
authors.initials: S
authors.lastname: Nagao
authors.forename: Shunji
authors.initials: S
authors.lastname: Kawamoto
authors.forename: Takakazu
authors.initials: T
authors.lastname: Sasaguri
authors.forename: Katsuo
authors.initials: K
authors.lastname: Sueishi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D020360:Neoadjuvant Therapy; D010094:Oxonic Acid / Q000008:administration & dosage; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin