title: Descriptive Epidemiology and Whole Genome Sequencing Analysis for an Outbreak of Bovine Tuberculosis in Beef Cattle and White-Tailed Deer in Northwestern Minnesota.
abstract: Bovine tuberculosis (bTB) was discovered in a Minnesota cow through routine slaughter surveillance in 2005 and the resulting epidemiological investigation led to the discovery of infection in both cattle and white-tailed deer in the state. From 2005 through 2009, a total of 12 beef cattle herds and 27 free-ranging white-tailed deer (Odocoileus virginianus) were found infected in a small geographic region of northwestern Minnesota. Genotyping of isolates determined both cattle and deer shared the same strain of bTB, and it was similar to types found in cattle in the southwestern United States and Mexico. Whole genomic sequencing confirmed the introduction of this infection into Minnesota was recent, with little genetic divergence. Aggressive surveillance and management efforts in both cattle and deer continued from 2010-2012; no additional infections were discovered. Over 10,000 deer were tested and 705 whole herd cattle tests performed in the investigation of this outbreak.
authors.affiliation: Minnesota Board of Animal Health, St. Paul, Minnesota, United States of America.
authors.forename: Linda
authors.initials: L
authors.lastname: Glaser
authors.affiliation: Wildlife Health Program, Minnesota Department of Natural Resources, Forest Lake, Minnesota, United States of America.
authors.forename: Michelle
authors.initials: M
authors.lastname: Carstensen
authors.affiliation: Veterinary Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Madison, Wisconsin, United States of America.
authors.forename: Sheryl
authors.initials: S
authors.lastname: Shaw
authors.affiliation: National Veterinary Services Laboratories, Veterinary Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Ames, Iowa, United States of America.
authors.forename: Suelee
authors.initials: S
authors.lastname: Robbe-Austerman
authors.affiliation: Department of Veterinary Population Medicine, Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America.
authors.forename: Arno
authors.initials: A
authors.lastname: Wunschmann
authors.affiliation: Centers for Epidemiology and Animal Health, Veterinary Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, Colorado, United States of America.
authors.forename: Dan
authors.initials: D
authors.lastname: Grear
authors.affiliation: National Veterinary Services Laboratories, Veterinary Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Ames, Iowa, United States of America.
authors.forename: Tod
authors.initials: T
authors.lastname: Stuber
authors.affiliation: National Veterinary Services Laboratories, Veterinary Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Ames, Iowa, United States of America.
authors.forename: Bruce
authors.initials: B
authors.lastname: Thomsen
mesh_terms: D000818:Animals; D002417:Cattle; D003670:Deer; D004196:Disease Outbreaks / Q000662:veterinary*; D016680:Genome, Bacterial; D008910:Minnesota; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification; D014380:Tuberculosis, Bovine / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission