title: Chitosan-gelatin-based microgel for sustained drug delivery.
abstract: We describe here the proof-of-concept of synthesizing microgels via cross-linking of chitosan and gelatin with succinimide-end polyethylene glycol (PEG). The introduction of PEG provided thermo-responsiveness to microgels, and the size of microgels significantly changed with increasing temperature. Furthermore, the microgel was biocompatible as confirmed in vitro by MTT assay with NIH 3T3 fibroblast and degradable. Chitosan-based microgels exhibited strong affinity to hydrophobic drug and prolonged release of folic acid was observed at physiological temperature with varying pH. The proposed cost-effective injectable microgels have the potential to serve as the delivery vehicle of hydrophobic bioactive molecules.
authors.affiliation: a Biomaterials and Macromolecular Science and Engineering Laboratory, Department of Metallurgical, Materials and Biomedical Engineering , University of Texas at El Paso , El Paso , TX , USA.
authors.forename: K
authors.initials: K
authors.lastname: Wang
authors.affiliation: b College of Chemistry , Beijing Normal University , Beijing , China.
authors.forename: S
authors.initials: S
authors.lastname: Lin
authors.affiliation: a Biomaterials and Macromolecular Science and Engineering Laboratory, Department of Metallurgical, Materials and Biomedical Engineering , University of Texas at El Paso , El Paso , TX , USA.
authors.forename: K C
authors.initials: KC
authors.lastname: Nune
authors.affiliation: a Biomaterials and Macromolecular Science and Engineering Laboratory, Department of Metallurgical, Materials and Biomedical Engineering , University of Texas at El Paso , El Paso , TX , USA.
authors.forename: R D K
authors.initials: RD
authors.lastname: Misra
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D005780:Gelatin / Q000737:chemistry*; D005782:Gels; D007267:Injections; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D011092:Polyethylene Glycols / Q000737:chemistry; D013388:Succinimides; D013552:Swine; D013696:Temperature
chemical_list: D004337:Drug Carriers; D005782:Gels; D013388:Succinimides; C032620:succinimide; D011092:Polyethylene Glycols; D005780:Gelatin; D048271:Chitosan
keywords: Microgel; biocompatibility; chitosan; drug delivery; fluorescence