title: Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system.
abstract: This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, β-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between β-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems.
authors.affiliation: Department of Chemistry Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
authors.forename: Hyeonjeong
authors.initials: H
authors.lastname: Jeon
authors.affiliation: Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea.
authors.forename: Jihoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea.
authors.forename: Yeong Mi
authors.initials: YM
authors.lastname: Lee
authors.affiliation: Department of Chemistry Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
authors.forename: Jinhwan
authors.initials: J
authors.lastname: Kim
authors.affiliation: Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea.
authors.forename: Hyung Woo
authors.initials: HW
authors.lastname: Choi
authors.affiliation: Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea.
authors.forename: Junseok
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Chemistry Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
authors.forename: Hyeongmok
authors.initials: H
authors.lastname: Park
authors.affiliation: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
authors.forename: Youngnam
authors.initials: Y
authors.lastname: Kang
authors.affiliation: Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 136-791 and KU-KIST School, Korea University, Seoul 02841, Republic of Korea.
authors.forename: In-San
authors.initials: IS
authors.lastname: Kim
authors.affiliation: Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 700-421, Republic of Korea.
authors.forename: Byung-Heon
authors.initials: BH
authors.lastname: Lee
authors.affiliation: Bioengineering Department, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Allan S
authors.initials: AS
authors.lastname: Hoffman
authors.affiliation: Department of Chemistry Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea; Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea. Electronic address: wjkim@postech.ac.kr.
authors.forename: Won Jong
authors.initials: WJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D017239:Paclitaxel / Q000737:chemistry* / Q000494:pharmacology; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties; D050559:beta-Carotene 15,15'-Monooxygenase / Q000276:immunology; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D058185:Magnetite Nanoparticles; D011108:Polymers; D047392:beta-Cyclodextrins; C493359:Bco1 protein, mouse; D050559:beta-Carotene 15,15'-Monooxygenase; D017239:Paclitaxel
keywords: Cyclodextrin; Magnetic-guided drug delivery; Multivalent host-guest chemistry; Paclitaxel; SPION