title: Val66Met BDNF polymorphism is associated with Parkinson's disease cognitive impairment.
abstract: Parkinson's disease (PD) is one of the most common neurodegenerative diseases worldwide. Besides characteristic PD motor features, the disease has important non-motor characteristics such as cognitive impairment. The role of genetic factors in cognitive impairment associated with PD is still unclear. In this study, we examined whether BDNF Val66Met was associated with impaired cognition in Parkinson's disease. One hundred and seventy five patients with a clinical diagnosis of Parkinson's disease were included. Global cognitive abilities of the patients were measured by the Mini-Mental State Examination (MMSE). Poisson Regression models were used to test for association between 66Met carriers and cognitive impairment controlling for covariates. Carriers of at least one BDNF 66Met allele presented a higher prevalence of cognitive impairment (p=0.005 RR=1.45 IC=95% [1.1-1.8]). These results suggest a role for BDNF Val66Met polymorphism on cognitive impairment in PD.
authors.affiliation: Departamento de Genética, Universidade Federal do Rio Grande do Sul, Brazil.
authors.forename: Vivian
authors.initials: V
authors.lastname: Altmann
authors.affiliation: Departamento de Genética, Universidade Federal do Rio Grande do Sul, Brazil; Servico de Neurologia, Hospital de Clínicas de Porto Alegre, Brazil.
authors.forename: Artur F
authors.initials: AF
authors.lastname: Schumacher-Schuh
authors.affiliation: Departamento de Genética, Universidade Federal do Rio Grande do Sul, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Rieck
authors.affiliation: Departamento de Estatística, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Sidia M
authors.initials: SM
authors.lastname: Callegari-Jacques
authors.affiliation: Servico de Neurologia, Hospital de Clínicas de Porto Alegre, Brazil.
authors.forename: Carlos R M
authors.initials: CR
authors.lastname: Rieder
authors.affiliation: Departamento de Genética, Universidade Federal do Rio Grande do Sul, Brazil. Electronic address: mara.hutz@ufrgs.br.
authors.forename: Mara H
authors.initials: MH
authors.lastname: Hutz
mesh_terms: D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003072:Cognition Disorders / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D011110:Polymorphism, Genetic
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: BDNF; Cognitive impairment; Genetic susceptibility; Parkinson's disease