title: The role of AEG-1 in the development of liver cancer.
abstract: AEG-1 is an oncogene that is overexpressed in all cancers, including hepatocellular carcinoma. AEG-1 plays a seminal role in promoting cancer development and progression by augmenting proliferation, invasion, metastasis, angiogenesis and chemoresistance, all hallmarks of aggressive cancer. AEG-1 mediates its oncogenic function predominantly by interacting with various protein complexes. AEG-1 acts as a scaffold protein, activating multiple protumorigenic signal transduction pathways, such as MEK/ERK, PI3K/Akt, NF-κB and Wnt/β-catenin while regulating gene expression at transcriptional, post-transcriptional and translational levels. Our recent studies document that AEG-1 is fundamentally required for activation of inflammation. A comprehensive and convincing body of data currently points to AEG-1 as an essential component critical to the onset and progression of cancer. The present review describes the current knowledge gleaned from patient and experimental studies as well as transgenic and knockout mouse models, on the impact of AEG-1 on hepatocarcinogenesis.
authors.affiliation: Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
authors.forename: Chadia L
authors.initials: CL
authors.lastname: Robertson
authors.affiliation: Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Srivastava
authors.affiliation: Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
authors.forename: Devaraja
authors.initials: D
authors.lastname: Rajasekaran
authors.affiliation: Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Gredler
authors.affiliation: Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
authors.forename: Maaged A
authors.initials: MA
authors.lastname: Akiel
authors.affiliation: Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Jariwala
authors.affiliation: Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
authors.forename: Ayesha
authors.initials: A
authors.lastname: Siddiq
authors.affiliation: Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA; VCU Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.
authors.forename: Luni
authors.initials: L
authors.lastname: Emdad
authors.affiliation: Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA; VCU Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Molecular Medicine Research Building 1220 East Broad Street, 7th Floor PO Box 980033, Richmond, VA 23298-0033, USA.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Fisher
authors.affiliation: Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA; VCU Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Molecular Medicine Research Building 1220 East Broad Street, 7th Floor PO Box 980033, Richmond, VA 23298-0033, USA.
authors.forename: Devanand
authors.initials: D
authors.lastname: Sarkar
keywords: AEG-1; angiogenesis; chemoresistance; hepatocellular carcinoma; inflammation; metastasis