title: Polymorphism of FCGR2A, FCGR2C, and FCGR3B Genes in the Pathogenesis of Sarcoidosis.
abstract: We have previously presented evidence that the polymorphism of the FCGR3A gene, encoding the receptor for Fc fragment of immunoglobulin G IIIa (FcγRIIIa) plays a role in the enhancement of circulating immune complexes (CIs) with the occurrence of Mycobacterium tuberculosis heat shock proteins in patients with sarcoidosis (SA). The immunocomplexemia might be caused by decreased affinity of CIs to Fcγ receptors, with the subsequently decreased receptor clearance by immune cells. In the present study we examined whether the polymorphisms of other related genes (FCGR2A, FCGR2C, FCGR3B) encoding other activatory Fcγ receptors, could have a similar effect. To this end, we genotyped 124 patients with sarcoidosis and 148 healthy volunteers using polymerase chain reaction with sequence-specific primers. We revealed a significant decrease in the percentage of the FCGR2A and FCGR2C variants that ensure effective CIs clearance, with a concomitant increase of less functional variants of these genes in Stages I/II, compared with Stages III/IV of SA. There was no aberration in FCGR3B allele/genotype frequencies. We conclude that the FCGR2A and FCGR2C polymorphisms may also contribute to immunocomplexemia present in SA. The assessment of FCGR genes could become a tool in presaging a clinical course of sarcoidosis and in its personalized therapy.
authors.affiliation: Department of Pulmonology, Medical University of Gdansk, 7 Debinki St, 80-211, Gdansk, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Typiak
authors.affiliation: Department of Forensic Medicine, Medical University of Gdansk, 23 Debowa St, 80-204, Gdansk, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Rębała
authors.affiliation: Non-invasive Cardiac Diagnostic Department, Medical University of Gdansk, 17 Mariana Smoluchowskiego St, 80-214, Gdansk, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Dudziak
authors.affiliation: Department of Pulmonology, Medical University of Gdansk, 7 Debinki St, 80-211, Gdansk, Poland.
authors.forename: J M
authors.initials: JM
authors.lastname: Słomiński
authors.affiliation: Department of Pulmonology, Medical University of Gdansk, 7 Debinki St, 80-211, Gdansk, Poland. aduban@gumed.edu.pl.
authors.forename: A
authors.initials: A
authors.lastname: Dubaniewicz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D012507:Sarcoidosis / Q000235:genetics*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: C445323:FCGR2A protein, human; C000609718:FCGR2C protein, human; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D017452:Receptors, IgG
keywords: FCGR genes; Immunoglobulin G; Polymorphism; Receptor; Sarcoidosis