title: Co-infection of Epstein-Barr virus and human papillomavirus in human tumorigenesis.
abstract: Viral infections contribute to approximately 12% of cancers worldwide, with the vast majority occurring in developing countries and areas. Two DNA viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), are associated with 38% of all virus-associated cancers. The probability of one patient infected with these two distinct types of viruses is increasing. Here, we summarize the co-infection of EBV and HPV in human malignancies and address the possible mechanisms for the co-infection of EBV and HPV during tumorigenesis.
authors.affiliation: Cancer Research Institute, Central South University, Changsha, 410078, Hunan, P. R. China. yingshi@csu.edu.cn.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, Hunan, P. R. China. yingshi@csu.edu.cn.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha, 410078, Hunan, P. R. China. yingshi@csu.edu.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Cancer Research Institute, Central South University, Changsha, 410078, Hunan, P. R. China. songlingpeng90@163.com.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, Hunan, P. R. China. songlingpeng90@163.com.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha, 410078, Hunan, P. R. China. songlingpeng90@163.com.
authors.forename: Song-Ling
authors.initials: SL
authors.lastname: Peng
authors.affiliation: Cancer Research Institute, Central South University, Changsha, 410078, Hunan, P. R. China. yanglifang@csu.edu.cn.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, Hunan, P. R. China. yanglifang@csu.edu.cn.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha, 410078, Hunan, P. R. China. yanglifang@csu.edu.cn.
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Yang
authors.affiliation: Cancer Research Institute, Central South University, Changsha, 410078, Hunan, P. R. China. cx_shirley@163.com.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, Hunan, P. R. China. cx_shirley@163.com.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha, 410078, Hunan, P. R. China. cx_shirley@163.com.
authors.forename: Xue
authors.initials: X
authors.lastname: Chen
authors.affiliation: Cancer Research Institute, Central South University, Changsha, 410078, Hunan, P. R. China. taoyong@csu.edu.cn.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, Hunan, P. R. China. taoyong@csu.edu.cn.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha, 410078, Hunan, P. R. China. taoyong@csu.edu.cn.
authors.forename: Yong-Guang
authors.initials: YG
authors.lastname: Tao
authors.affiliation: Cancer Research Institute, Central South University, Changsha, 410078, Hunan, P. R. China. ycao98@vip.sina.com.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, Hunan, P. R. China. ycao98@vip.sina.com.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha, 410078, Hunan, P. R. China. ycao98@vip.sina.com.
authors.forename: Ya
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000071478:APOBEC Deaminases; D060085:Coinfection / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control / Q000821:virology; D003564:Cytidine Deaminase; D043525:Cytosine Deaminase / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics / Q000821:virology*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control; D014765:Viral Vaccines / Q000627:therapeutic use
chemical_list: D014765:Viral Vaccines; D043525:Cytosine Deaminase; D000071478:APOBEC Deaminases; C502889:APOBEC3 proteins, human; D003564:Cytidine Deaminase