title: Biotransformation of patchoulol by Cunninghamella echinulata var. elegans.
abstract: Biocatalysis of patchoulol (PA) was performed by the fungus Cunninghamella echinulata var. elegans. Eight metabolites (1-8) including four new compounds were obtained, and their structures were elucidated as (5R,8S)-5,8 dihydroxypatchoulol (1), (5R*,9R*)-5,9 dihydroxypatchoulol (2), (6S*, 9S*)-6,9 dihydroxypatchoulol (3), and (4R*)-4 hydroxypatchoulol (4) by spectroscopic analysis. The absolute configuration of 1 was determined by single crystal X-ray diffraction.
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Xu
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, China.
authors.forename: Kangsheng
authors.initials: K
authors.lastname: Liao
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
authors.forename: Zhenbiao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China. Electronic address: daguo@simm.ac.cn.
authors.forename: Dean
authors.initials: D
authors.lastname: Guo
authors.affiliation: College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address: suziren@gzucm.edu.cn.
authors.forename: Ziren
authors.initials: Z
authors.lastname: Su
authors.affiliation: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, China. Electronic address: doctliu@263.net.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
mesh_terms: D001711:Biotransformation; D018360:Crystallography, X-Ray; D020093:Cunninghamella / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000378:metabolism*
chemical_list: D012717:Sesquiterpenes; C052983:patchouli alcohol
keywords: Biotransformation; Cunninghamella echinulata var. elegans; Patchoulol; X-ray crystallography