title: Opposite Sex Contact and Isolation: A Novel Depression/Anxiety Model.
abstract: To mimic human mood disorders, traditional chronic stresses and social defeat stress have been developed and widely applied. However, these active stresses do not mimic the emotional flaws induced by stresses, and their input levels vary greatly. Also, emotional stresses resulting from social unobtainability remain largely elusive due to the lack of useful animal models. In this study, we developed a mouse model named "opposite sex contact and isolation" (OSCI) and found that OSCI induced significant social avoidance, anhedonia, and anxiety. These behavioral defects developed differently after 7 days of OSCI. The social avoidance behavior was self-curable while anxiety gradually worsened but was alleviated by re-pairing with the same female partner. Corresponding to the behavior changes, the plasma corticosterone and phosphorylated cAMP response element binding protein levels were decreased in the nucleus accumbens of the mice that experienced isolation. Together, this study has developed a novel strategy for depression/anxiety modeling and shows that OSCI may be a useful tool for studying the lovelorn/lovesick type of depression.
authors.affiliation: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. ribaike@163.com.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Shanghai, 200032, China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Shi
authors.affiliation: Liver Cancer Institute, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Integrative Medicine and Neurobiology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Qiu-Qin
authors.initials: QQ
authors.lastname: Han
authors.affiliation: Department of Integrative Medicine and Neurobiology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Integrative Medicine and Neurobiology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Gen-Cheng
authors.initials: GC
authors.lastname: Wu
authors.affiliation: Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Shanghai, 200032, China. yuqiuzhang@fudan.edu.cn.
authors.forename: Yu-Qiu
authors.initials: YQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001007:Anxiety / Q000209:etiology* / Q000523:psychology; D001522:Behavior, Animal; D003345:Corticosterone / Q000097:blood; D017362:Cyclic AMP Response Element-Binding Protein / Q000096:biosynthesis; D003863:Depression / Q000209:etiology* / Q000523:psychology; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D008297:Male; D018782:Maze Learning; D051379:Mice; D008810:Mice, Inbred C57BL; D009714:Nucleus Accumbens / Q000378:metabolism; D012934:Social Isolation / Q000523:psychology*
chemical_list: C492004:Creb1 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D003345:Corticosterone
keywords: Anxiety; Depression; Lovelorn; Opposite sex contact; Social isolation; Social stress