title: Perioperative use of centrally acting angiotensin-converting enzyme inhibitor may increase patients' risk for postoperative nausea and vomiting.
abstract: Substance P (SP) is involved in the development of postoperative nausea and vomiting (PONV). It is hydrolyzed by angiotensin-converting enzyme (ACE). Centrally acting ACE inhibitors (CACE-Is) are widely used in the perioperative period. The current evidence showed CACE-Is could upregulate SP level in the central nervous system which may contribute to the occurrence of PONV in 0-72 h. Here, we present our hypothesis that the use of CACE-Is in the perioperative period may increase patients' risk for both early (0-24h) and late (24-72 h) PONV. The identification of this new risk factor may improve patients' risk assessment and thus lead to better prophylaxis strategies for PONV that are base on risk stratification.
authors.affiliation: Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Xiong
authors.affiliation: Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Liting
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Dongjiao
authors.initials: D
authors.lastname: An
authors.affiliation: Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Meijiang
authors.initials: M
authors.lastname: Lu
authors.affiliation: Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Wenzhen
authors.initials: W
authors.lastname: Shen
authors.affiliation: Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Yue
authors.affiliation: Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Electronic address: wuanshi1965@163.com.
authors.forename: Anshi
authors.initials: A
authors.lastname: Wu
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002491:Central Nervous System Agents / Q000009:adverse effects*; D019317:Evidence-Based Medicine; D006801:Humans; D015994:Incidence; D008954:Models, Biological; D019990:Perioperative Care / Q000379:methods; D020250:Postoperative Nausea and Vomiting / Q000201:enzymology* / Q000453:epidemiology*; D012307:Risk Factors; D013373:Substance P / Q000378:metabolism*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002491:Central Nervous System Agents; D013373:Substance P