title: Arkypallidal Cells Send a Stop Signal to Striatum.
abstract: The suppression of inappropriate actions is critical for flexible behavior. Cortical-basal ganglia networks provide key gating mechanisms for action suppression, yet the specific roles of neuronal subpopulations are poorly understood. Here, we examine Arkypallidal (‘‘Arky’’) and Prototypical (‘‘Proto’’) globus pallidus neurons during a Stop task, which requires abrupt cancellation of an imminent action. We first establish that Arky neurons can be identified by their firing properties across the natural sleep/wake cycle. We then show that Stop responses are earlier and stronger in the Arky compared to the Proto subpopulation. In contrast to other basal ganglia neurons, pallidal Stop responses are selective to Stop, rather than Go, cues. Furthermore, the timing of these Stop responses matches the suppression of developing striatal Go-related activity. Our results support a two-step model of action suppression: actions-inpreparation are first paused via a subthalamic-nigral pathway, then cancelled via Arky GABAergic projections to striatum.
authors.affiliation: Universite de Bordeaux, Institut des Maladies Neurodegeneratives, 33076 Bordeaux, France
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mallet
authors.forename: Robert
authors.initials: R
authors.lastname: Schmidt
authors.forename: Daniel
authors.initials: D
authors.lastname: Leventhal
authors.forename: Fujun
authors.initials: F
authors.lastname: Chen
authors.forename: Nada
authors.initials: N
authors.lastname: Amer
authors.forename: Thomas
authors.initials: T
authors.lastname: Boraud
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Berke
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003342:Corpus Striatum / Q000166:cytology / Q000502:physiology*; D005917:Globus Pallidus / Q000166:cytology / Q000502:physiology*; D007175:Impulsive Behavior / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012894:Sleep Stages / Q000502:physiology*