title: Lack of association between polymorphisms in the SIRT6 gene and longevity in a Chinese population.
abstract: Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity.
authors.affiliation: Department of Biology, Hainan Medical College, Haikou, Hainan 571199, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Lin
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan 571199, China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan 571199, China.
authors.forename: Dongjing
authors.initials: D
authors.lastname: Yan
authors.affiliation: Department of Neurology, The Affiliated Hospital of Hainan Medical College, Haikou, Hainan 571199, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Liao
authors.affiliation: Department of Biology, Hainan Medical College, Haikou, Hainan 571199, China.
authors.forename: Gu
authors.initials: G
authors.lastname: Gong
authors.affiliation: Department of Biology, Hainan Medical College, Haikou, Hainan 571199, China; College of Agriculture, Hainan University, Haikou, Hainan 570228, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Hu
authors.affiliation: Division of Biostatistics and Human Genetics Center, The University of Texas Health Science Center at Houston, 1200 Herman Pressler, Houston, TX 77025, USA; Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, Yunnan 650091, China. Electronic address: yunxin.fu@uth.tmc.edu.
authors.forename: Yunxin
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan 571199, China. Electronic address: caiww591020@163.com.
authors.forename: Wangwei
authors.initials: W
authors.lastname: Cai
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D015810:Linkage Disequilibrium; D008136:Longevity; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D037761:Sirtuins / Q000235:genetics*
chemical_list: C516592:SIRT6 protein, human; D037761:Sirtuins
keywords: Association study; Longevity; Polymorphism; SIRT6