title: [The mechanisms of prostate cancer progression through androgen receptor].
abstract: Androgen receptor(AR) has a critical role in prostate cancer(PCa) progression and targeting AR axis signaling by androgen deprivation therapy is a standard treatment for advanced PCa. Recently, the role of AR even in castration-resistant PCa(CRPC) is well recognized and emerging evidence suggests survival advantages of treatment by targeting AR in CRPC. This review outlines AR functions that contribute to PCa progression, AR structural alterations and AR activation via intracrine, co-factors, and kinase pathways in CRPC. Finally, we describe about recently reported bipolar androgen therapy as a novel treatment for CRPC targeting AR.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Goto
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Ichikawa
mesh_terms: D017398:Alternative Splicing; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D009154:Mutation; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*
chemical_list: C410798:AR protein, human; D011944:Receptors, Androgen