title: Nanotechnology for delivery of peptide nucleic acids (PNAs).
abstract: Over the past three decades, peptide nucleic acids have been employed in numerous chemical and biological applications. Peptide nucleic acids possess enormous potential because of their superior biophysical properties, compared to other oligonucleotide chemistries. However, for therapeutic applications, intracellular delivery of peptide nucleic acids remains a challenge. In this review, we summarize the progress that has been made in delivering peptide nucleic acids to intracellular targets. In addition, we emphasize recent nanoparticle-based strategies for efficient delivery of conventional and chemically-modified peptides nucleic acids.
authors.affiliation: Department of Therapeutic Radiology, Yale University, New Haven, CT, USA.
authors.forename: Anisha
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Therapeutic Radiology, Yale University, New Haven, CT, USA.
authors.forename: Raman
authors.initials: R
authors.lastname: Bahal
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT, USA; Department of Chemical Engineering, Indian Institute of Technology-Delhi, New Delhi, India.
authors.forename: Meera
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Department of Therapeutic Radiology, Yale University, New Haven, CT, USA; Department of Genetics, Yale University, New Haven, CT, USA. Electronic address: peter.glazer@yale.edu.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Glazer
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT, USA. Electronic address: mark.saltzman@yale.edu.
authors.forename: W Mark
authors.initials: WM
authors.lastname: Saltzman
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D020135:Peptide Nucleic Acids / Q000008:administration & dosage* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004337:Drug Carriers; D020135:Peptide Nucleic Acids
keywords: Antisense therapy; Gene editing; Nanoparticles; Peptide nucleic acids