title: The total synthesis of calcium atorvastatin.
abstract: A practical and convergent asymmetric route to calcium atorvastatin (1) is reported. The synthesis of calcium atorvastatin (1) was performed using the remote 1,5-anti asymmetric induction in the boron-mediated aldol reaction of β-alkoxy methylketone (4) with pyrrolic aldehyde (3) as a key step. Calcium atorvastatin was obtained from aldehyde (3) after 6 steps, with a 41% overall yield.
authors.affiliation: Instituto de Química, Universidade Estadual de Campinas, UNICAMP, P.O. Box 6154, 13084-971 Campinas, SP, Brazil. ldias@iqm.unicamp.br.
authors.forename: Luiz C
authors.initials: LC
authors.lastname: Dias
authors.forename: Adriano S
authors.initials: AS
authors.lastname: Vieira
authors.forename: Eliezer J
authors.initials: EJ
authors.lastname: Barreiro
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000069059:Atorvastatin / Q000138:chemical synthesis* / Q000737:chemistry; D001895:Boron / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000379:methods; D015394:Molecular Structure
chemical_list: D000447:Aldehydes; C116609:3-hydroxybutanal; D000069059:Atorvastatin; D001895:Boron