title: Heart acceleration and deceleration capacities associated with dilated cardiomyopathy.
abstract: BACKGROUND
  Heart rate deceleration capacity and acceleration capacity are novel autonomic nervous system indicators of cardiac neural regulation. Dilated cardiomyopathy (DCM) changes cardiac electrophysiology; however, how deceleration capacity and acceleration capacity associated with DCM remain unclear.
  
  
  METHODS
  To evaluate the association between heart rate acceleration capacity, deceleration capacity and DCM, 66 DCM patients with DCM and 209 controls were enrolled in the study. Demographic data, echocardiographic data, heart rate variability, deceleration capacity and acceleration capacity were collected. The association pattern between DCM and these indexes were studied by multiple logistic regression analysis.
  
  
  RESULTS
  Deceleration capacity and acceleration capacity were independent risk factors for DCM with an odds ratio (OR) and 95% confidence interval (CI), determined by multiple logistic regression analysis, of 7·97 (3·87-16·42) and 0·09 (0·05-0·19), respectively. Univariate ordinal logistic regression analysis showed that acceleration capacity, fastest heart rate, standard deviation of normal-to-normal RR intervals (SDNN) and left ventricular ejection fraction (LEVF) associated with heart failure grade. The OR for each covariate was further adjusted for the effects of other significant covariates in multivariate ordinal logistic regression analysis. Acceleration capacity, fastest heart rate and LVEF were still independent risk factors in the final equation with ORs of 1·32 (1·03-1·79), 1·04 (0·01-1·07) and 0·46 (0·23-0·93), respectively.
  
  
  CONCLUSIONS
  Heart rate acceleration capacity and deceleration capacity are independent risk factors for DCM, and acceleration capacity is a predictive factor for heart failure exacerbation in patients with DCM.
authors.affiliation: Cardiology Department, First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Cao
authors.initials: C
authors.lastname: Zou
authors.affiliation: Cardiology Department, First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Hongkai
authors.initials: H
authors.lastname: Dong
authors.affiliation: Cardiology Department, First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Fengyan
authors.initials: F
authors.lastname: Wang
authors.affiliation: Electrocardiography Department, First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Meiwen
authors.initials: M
authors.lastname: Gao
authors.affiliation: Electrocardiography Department, First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Xingmei
authors.initials: X
authors.lastname: Huang
authors.affiliation: Electrocardiography Department, First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Jianling
authors.initials: J
authors.lastname: Jin
authors.affiliation: Echocardiography Department, First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Bingyuan
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Cardiology Department, First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Yang
mesh_terms: D000054:Acceleration; D001145:Arrhythmias, Cardiac / Q000150:complications* / Q000503:physiopathology; D002311:Cardiomyopathy, Dilated / Q000209:etiology* / Q000503:physiopathology; D003654:Deceleration; D015716:Electrocardiography, Ambulatory; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors
keywords: Dilated cardiomyopathy; electrophysiology; heart rate acceleration capacity; heart rate deceleration capacity