title: Economic Impact of a New Rapid PCR Assay for Detecting Influenza Virus in an Emergency Department and Hospitalized Patients.
abstract: Seasonal influenza causes significant morbidity and mortality and has a substantial economic impact on the healthcare system. The main objective of this study was to compare the cost per patient for a rapid commercial PCR assay (Xpert® Flu) with an in-house real-time PCR test for detecting influenza virus. Community patients with influenza like-illness attending the Emergency Department (ED) as well as hospitalized patients in the Hospital Clínic of Barcelona were included. Costs were evaluated from the perspective of the hospital considering the use of resources directly related to influenza testing and treatment. For the purpose of this study, 366 and 691 patients were tested in 2013 and 2014, respectively. The Xpert® Flu test reduced the mean waiting time for patients in the ED by 9.1 hours and decreased the mean isolation time of hospitalized patients by 23.7 hours. This was associated with a 103€ (or about $113) reduction in the cost per patient tested in the ED and 64€ ($70) per hospitalized patient. Sensitivity analyses showed that Xpert® Flu is likely to be cost-saving in hospitals with different contexts and prices.
authors.affiliation: Fundació Clínic per a la Recerca Biomèdica, Barcelona, Spain.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Soto
authors.affiliation: Health Technology Assessment Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Sampietro-Colom
authors.affiliation: Public Health Department, Hospital Clínic, University of Barcelona, Barcelona, Spain.|ISGlobal Barcelona Institute for Global Health, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Vilella
authors.affiliation: Public Health Department, Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: Efraín
authors.initials: E
authors.lastname: Pantoja
authors.affiliation: Emergency Department, Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Asenjo
authors.affiliation: ISGlobal Barcelona Institute for Global Health, Barcelona, Spain.|Department of Clinical Microbiology, Biomedical Diagnostic Centre (CDB), Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: Ruth
authors.initials: R
authors.lastname: Arjona
authors.affiliation: ISGlobal Barcelona Institute for Global Health, Barcelona, Spain.|Department of Clinical Microbiology, Biomedical Diagnostic Centre (CDB), Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Hurtado
authors.affiliation: Public Health Department, Hospital Clínic, University of Barcelona, Barcelona, Spain.|ISGlobal Barcelona Institute for Global Health, Barcelona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Trilla
authors.affiliation: ISGlobal Barcelona Institute for Global Health, Barcelona, Spain.|Department of Clinical Microbiology, Biomedical Diagnostic Centre (CDB), Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: Míriam José
authors.initials: MJ
authors.lastname: Alvarez-Martínez
authors.affiliation: Biomedical Diagnostic Centre (CDB), Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: Aurea
authors.initials: A
authors.lastname: Mira
authors.affiliation: ISGlobal Barcelona Institute for Global Health, Barcelona, Spain.|Department of Clinical Microbiology, Biomedical Diagnostic Centre (CDB), Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Vila
authors.affiliation: ISGlobal Barcelona Institute for Global Health, Barcelona, Spain.|Department of Clinical Microbiology, Biomedical Diagnostic Centre (CDB), Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: María Angeles
authors.initials: MA
authors.lastname: Marcos
mesh_terms: D000328:Adult; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D009980:Influenza A virus; D007251:Influenza, Human / Q000097:blood* / Q000191:economics; D008297:Male; D016133:Polymerase Chain Reaction / Q000191:economics / Q000379:methods*; D012680:Sensitivity and Specificity