title: Correlation of miR-494 expression with tumor progression and patient survival in pancreatic cancer.
abstract: MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase chain reaction. We also analyzed the associations between miR-494 expression and clinicopathological features. The survival correlations were analyzed by using the Kaplan-Meier method and Cox proportional hazards model. The level of miR-494 expression was significantly downregulated in pancreatic cancer tissues (mean relative expression level ± SD, 0.48 ± 0.11) as compared to matched adjacent normal tissues (1.80 ± 0.28, P < 0.05). We found significant correlations between the miR-494 expression levels and TNM stage (P = 0.009), lymphatic invasion (P = 0.036), vascular invasion (P = 0.011), distant metastasis (P = 0.007), and tumor grade (P = 0.031). Pancreatic cancer patients with a low miR-494 expression level had a shorter overall survival than those with a high miR-494 expression level (P < 0.05). Reduced miR-494 expression in pancreatic cancer tissues is correlated with tumor progression and might be an independent, poor prognostic factor for patients with pancreatic cancer.
authors.affiliation: Department of Hepatobiliary Surgery, Shandong Provincial Hospital, ShanDong, China.|Department of Hepatobiliary Surgery, Weifang People's Hospital, Shandong, China.
authors.forename: Y B
authors.initials: YB
authors.lastname: Ma
authors.affiliation: Department of Gastroenterology, Shouguang People's Hospital, Shandong, China.
authors.forename: G X
authors.initials: GX
authors.lastname: Li
authors.affiliation: Department of General Surgery, Shouguang People's Hospital, Shandong, China.
authors.forename: J X
authors.initials: JX
authors.lastname: Hu
authors.affiliation: Department of Medical Oncology, Affiliated Hospital of Weifang Medical College, Shandong, China.
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Hepatobiliary Surgery, Shandong Provincial Hospital, ShanDong, China.|Department of General Surgery, Tongji Hospital of Tongji University, Shanghai, China.
authors.forename: B M
authors.initials: BM
authors.lastname: Shi
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D063646:Carcinogenesis; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C547168:MIRN494 microRNA, human; D035683:MicroRNAs