title: Observation of vasculature alternation by intense pulsed light combined with physicochemical methods.
abstract: Intense pulsed light (IPL) with low energy insufficient to completely destroy a vasculature was applied to rabbit ears to investigate vasculature alteration. Glycerol was combined with IPL to enhance the transfer efficacy of IPL energy. Both trans-illumination and laser speckle contrast images were obtained and analyzed after treatment. The application of IPL and glycerol combination induced vasodilation and improvement in blood flow. Moreover, such phenomenon was maintained over time. IPL may be applied to treat blood circulatory diseases by inducing vasodilation and to improve blood flow.
authors.affiliation: Department of Bioengineering, University of Illinois at Chicago, USA.
authors.forename: Taeyoon
authors.initials: T
authors.lastname: Son
authors.affiliation: Department of Biomedical Engineering, Yonsei University, Wonju, Korea; Center for Nano-Bio Measurement, Korea Research Institute of Standards and Science, Daejeon, 34113, Korea.
authors.forename: Heesung
authors.initials: H
authors.lastname: Kang
authors.affiliation: Department of Biomedical Engineering, Yonsei University, Wonju, Korea. Electronic address: bjung@yonsei.ac.kr.
authors.forename: Byungjo
authors.initials: B
authors.lastname: Jung
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D004423:Ear / Q000098:blood supply*; D005260:Female; D005990:Glycerol / Q000008:administration & dosage; D062325:Intense Pulsed Light Therapy / Q000295:instrumentation; D054025:Lasers, Dye; D023421:Models, Animal; D061848:Optical Imaging / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods*; D011817:Rabbits; D012039:Regional Blood Flow; D013997:Time Factors; D014664:Vasodilation
chemical_list: D005990:Glycerol
keywords: Blood vessel; Glycerol; IPL; Laser speckle imaging; Vasodilation