title: From drug eluting stents to bioresorbable scaffolds; to new horizons in PCI.
abstract: Drug eluting stents and particularly the fully bioresorbable drug-eluting scaffolds herald a new era in percutaneous treatment of coronary artery disease. There has been tremendous progress in drug eluting stents with fully biodegradable coating polymers and polymer-free devices with reservoir technology planting the anti-proliferative drug. Despite significant decreases in in-stent restenosis rates with drug eluting stents, limitations still remain before we are able to develop fully bioresorbable scaffolds. Enhanced mechanical flexibility that provides superior conformability to the vessel wall, resumption of the vasoreactivity in the follow-up period and improving visualization on non-invasive imaging modalities are some of the supremacies of the fully bioresorbable scaffolds. In this review, we aim to give a general view on the latest developments in metallic drug eluting stents and fully bioresorbable scaffolds.
authors.affiliation: a Department of Cardiology , ThoraxCentre, Erasmus Medical Center , Rotterdam , The Netherlands.
authors.forename: Erhan
authors.initials: E
authors.lastname: Tenekecioglu
authors.affiliation: b Institute of Cardiovascular Sciences , University College of London , London , UK.|c Department of Cardiology , Barts Health NHS Trust , London , UK.
authors.forename: Christos
authors.initials: C
authors.lastname: Bourantas
authors.affiliation: d Academic Medical Center , University of Amsterdam , Amsterdam , The Netherlands.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdelghani
authors.affiliation: a Department of Cardiology , ThoraxCentre, Erasmus Medical Center , Rotterdam , The Netherlands.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: a Department of Cardiology , ThoraxCentre, Erasmus Medical Center , Rotterdam , The Netherlands.
authors.forename: Rafael Cavalcante
authors.initials: RC
authors.lastname: Silva
authors.affiliation: a Department of Cardiology , ThoraxCentre, Erasmus Medical Center , Rotterdam , The Netherlands.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tateishi
authors.affiliation: d Academic Medical Center , University of Amsterdam , Amsterdam , The Netherlands.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Sotomi
authors.affiliation: a Department of Cardiology , ThoraxCentre, Erasmus Medical Center , Rotterdam , The Netherlands.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Onuma
authors.affiliation: e Department of Cardiology , Bursa Postgraduate Research and Education Hospital , Bursa , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yılmaz
authors.affiliation: a Department of Cardiology , ThoraxCentre, Erasmus Medical Center , Rotterdam , The Netherlands.|f International Centre for Circulatory Health , Imperial College , London , UK.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D054855:Drug-Eluting Stents; D006801:Humans; D018579:Patient Selection; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation*; D011108:Polymers / Q000737:chemistry; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D011108:Polymers
keywords: Drug eluting stents; anti-proliferative drug; biodegradable polymer; durable polymer; fully bioresorbable scaffold; polymer-free drug eluting stent