title: Regulation of the proteome by amino acids.
abstract: Besides their main contribution as substrates for protein synthesis, amino acids as signaling molecules could exert some regulatory functions on protein synthesis and/or proteolysis that have been emphasized in a number of recent studies. Several publications have highlighted supplemental roles of those amino acids in protein metabolism as well as in immunity, heat shock response, or apoptosis processes. In this way, via their regulatory properties, selected amino acids (such as leucine, glutamine, arginine, citrulline, or methionine) directly influence the proteome. In this review, we are proposing an overview of the regulation of the proteome by amino acids in mammals.
authors.affiliation: Plateforme de Protéomique PROMETHEE, IAB, University Grenoble Alpes, Grenoble, France.|Plateforme de Protéomique PROMETHEE, Institut de Biologie et de Pathologie, CHU de Grenoble, Grenoble, France.|Plateforme de Protéomique PROMETHEE, IAB, INSERM, Grenoble, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Bourgoin-Voillard
authors.affiliation: Laboratory of Fundamental and Applied Bioenergetics (LBFA), University Grenoble Alpes, Grenoble, France.|Laboratory of Fundamental and Applied Bioenergetics (LBFA), INSERM, Grenoble, France.
authors.forename: Arthur
authors.initials: A
authors.lastname: Goron
authors.affiliation: Plateforme de Protéomique PROMETHEE, IAB, University Grenoble Alpes, Grenoble, France.|Plateforme de Protéomique PROMETHEE, Institut de Biologie et de Pathologie, CHU de Grenoble, Grenoble, France.|Plateforme de Protéomique PROMETHEE, IAB, INSERM, Grenoble, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Seve
authors.affiliation: Laboratory of Fundamental and Applied Bioenergetics (LBFA), University Grenoble Alpes, Grenoble, France.|Laboratory of Fundamental and Applied Bioenergetics (LBFA), INSERM, Grenoble, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Moinard
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism*; D002956:Citrulline / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D006801:Humans; D007930:Leucine / Q000378:metabolism*; D008715:Methionine / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000502:physiology*; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D020543:Proteome; D005973:Glutamine; D002956:Citrulline; D001120:Arginine; D008715:Methionine; D058570:TOR Serine-Threonine Kinases; D007930:Leucine
keywords: Animal proteomics; Arginine; Citrulline; Glutamine; Leucine; Methionine