title: Central blood pressure and chronic kidney disease.
abstract: In this review, we focused on the relationship between central blood pressure and chronic kidney diseases (CKD). Wave reflection is a major mechanism that determines central blood pressure in patients with CKD. Recent medical technology advances have enabled non-invasive central blood pressure measurements. Clinical trials have demonstrated that compared with brachial blood pressure, central blood pressure is a stronger risk factor for cardiovascular (CV) and renal diseases. CKD is characterized by a diminished renal autoregulatory ability, an augmented direct transmission of systemic blood pressure to glomeruli, and an increase in proteinuria. Any elevation in central blood pressure accelerates CKD progression. In the kidney, interstitial inflammation induces oxidative stress to handle proteinuria. Oxidative stress facilitates atherogenesis, increases arterial stiffness and central blood pressure, and worsens the CV prognosis in patients with CKD. A vicious cycle exists between CKD and central blood pressure. To stop this cycle, vasodilator antihypertensive drugs and statins can reduce central blood pressure and oxidative stress. Even in early-stage CKD, mineral and bone disorders (MBD) may develop. MBD promotes oxidative stress, arteriosclerosis, and elevated central blood pressure in patients with CKD. Early intervention or prevention seems necessary to maintain vascular health in patients with CKD.
authors.affiliation: Yoichi Ohno, Department of Nephrology, Saitama Medical University, Saitama 350-0495, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ohno
authors.affiliation: Yoichi Ohno, Department of Nephrology, Saitama Medical University, Saitama 350-0495, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kanno
authors.affiliation: Yoichi Ohno, Department of Nephrology, Saitama Medical University, Saitama 350-0495, Japan.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Takenaka
keywords: Atherosclerosis; Mineral and bone disorder; Oxidative stress; Proteinuria; Renal autoregulation