title: Severe Lower Gastrointestinal Bleeding in a Patient with Crohn's Disease: a Case Report and the Review of Literature.
abstract: Crohn's disease (CD) is rarely presented with lower GI bleeding (LGIB) which eludes the clinician. A 25-year-old lady with severe rectorrhagia was presented with no history of constipation, diarrhea or abdominal pain. Colonoscopy revealed ulcers in the rectum, sigmoid colon, and terminal ileum. Crohn's pathologic features were detected in the terminal ileum. The bleeding was controlled via supportive care and IV corticosteroid. Recurrent LGIB was managed by prednisolone and azathioprine. The patient had an uneventful recovery. The clinicians should consider CD as a possible diagnosis in severe LGIB. Prednisolone and azathioprine efficiently control acute bleeding episodes and prevent the recurrence.
authors.affiliation: Digestive Diseases Research Center, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran.
authors.forename: Pedram
authors.initials: P
authors.lastname: Paragomi
authors.affiliation: Digestive Diseases Research Center, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran.
authors.forename: Kamran
authors.initials: K
authors.lastname: Moradi
authors.affiliation: Digestive Diseases Research Center, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran.
authors.forename: Pejman
authors.initials: P
authors.lastname: Khosravi
authors.affiliation: Digestive Diseases Research Center, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Ansari
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003424:Crohn Disease / Q000175:diagnosis*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use; D012007:Rectum; D012008:Recurrence; D014456:Ulcer / Q000473:pathology*
chemical_list: D000305:Adrenal Cortex Hormones; D011239:Prednisolone
keywords: Azathioprine; Corticosteroids; Crohn’s disease; Inflammatory bowel disease; Rectosigmoidoscopy; Severe hemorrhage