title: Effect of taking dietary supplement on hematological and biochemical parameters in male bodybuilders an equation model.
abstract: BACKGROUND
  The improved physical action following administration of supplements to bodybuilders was supported by changes in laboratory parameters. Despite the fact that these supplements are sometimes associated both advantage and side effects, this study were conducted for the purpose of evaluating the possible effects of some commonly used supplements in bodybuilders on the hematological and biochemical parameters.
  
  
  METHODS
  In this study, we included 40 male bodybuilders as cases and 40 controls in the age group of 20-40 years. They used different kinds of supplements for 1 year. In general, all the supplements used were classified into two groups: hormonal and non-hormonal. Laboratory tests were requested for evaluation of hematological and biochemical parameters.
  
  
  RESULTS
  In an equation model, we found that weight (P = 0.024), duration of bodybuilding (P < 0.001), and duration of hormone supplement consumption (P < 0.001) were loaded significantly on the latent variables, demographic and dietary supplement, respectively. The relationship between dietary supplement and biochemical and hematological parameters was significant (P = 0.01) and some of these parameters including creatinine (P = 0.023), blood aspartate aminotransferase (AST) (P < 0.001), alanine aminotransferase (ALT) (P < 0.001), and red blood cell distribution (RDW) (P = 0.046) had a significant role than others. In a multivariate regression model, we found that WBC (P < 0.001), platelets (P < 0.001), blood urea nitrogen (BUN; P < 0.001), creatinine (P < 0.001), AST (P = 0.005), and ALT (P = 0.001) were higher in athletes than in controls.
  
  
  CONCLUSIONS
  It is strongly advised that there should be some concerns about possible supplement-induced changes in the laboratory exams for bodybuilders. The available supplements are unchecked and not approved by the US Food and Drug Administration (FDA). More studies should be designed for a better and precise administration of each supplement in athletes.
authors.affiliation: Department of Medical Science, School of Medicine, Najafabad Branch, Islamic Azad University and Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Rokhsareh
authors.initials: R
authors.lastname: Meamar
authors.affiliation: Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Maracy
authors.affiliation: Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Nematollahi
authors.affiliation: Department of Medical Sciences, Najafabad Branch, Islamic Azad University, Isfahan, Iran.
authors.forename: Shemouil
authors.initials: S
authors.lastname: Yeroshalmi
authors.affiliation: Sayyd-Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Zamani-Moghaddam
authors.affiliation: Isfahan Center of Health Research, National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Reza Aghaye
authors.initials: MR
authors.lastname: Ghazvini
keywords: Bodybuilder; hematological and biochemical parameters; supplement