title: Phosphate binders in chronic kidney disease: a systematic review of recent data.
abstract: Hyperphosphatemia is common in chronic kidney disease (CKD) and is treated by dietary measures, dialysis techniques and/or phosphate binders. For the present review PubMed was searched for new publications on phosphate binders appearing between January 2010 and October 2015. This review summarizes the latest information on non-pharmacological measures and their problems in lowering phosphate in CKD patients, effects of phosphate binders on morbidity and mortality, adherence to phosphate binder therapy as well as new information on specific aspects of the various phosphate binders on the market: calcium acetate, calcium carbonate, magnesium-containing phosphate binders, polymeric phosphate binders (sevelamer, bixalomer, colestilan), lanthanum carbonate, ferric citrate, sucroferric oxyhydroxide, aluminum-containing phosphate binders, and new compounds in development. The review also briefly covers the emerging field of drugs targeting intestinal phosphate transporters.
authors.affiliation: Department of Nephrology and Clinical Immunology, University Hospital, RWTH University of Aachen, Pauwelsstr. 30, 52057, Aachen, Germany. jfloege@ukaachen.de.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Floege
mesh_terms: D004338:Drug Combinations; D005290:Ferric Compounds / Q000627:therapeutic use; D006801:Humans; D054559:Hyperphosphatemia / Q000188:drug therapy*; D007811:Lanthanum / Q000627:therapeutic use; D010710:Phosphates / Q000378:metabolism*; D011073:Polyamines / Q000627:therapeutic use; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy*; D000069603:Sevelamer / Q000627:therapeutic use; D013395:Sucrose / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D005290:Ferric Compounds; D010710:Phosphates; D011073:Polyamines; C000599459:sucroferric oxyhydroxide; C000589735:bixalomer; C119467:lanthanum carbonate; D013395:Sucrose; D007811:Lanthanum; D000069603:Sevelamer
keywords: Adherence; CKD; Phosphate binder; Phosphate transport