title: Social and novel contexts modify hippocampal CA2 representations of space.
abstract: The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated hippocampal subfield CA2 in social and contextual memory but how it does so remains unknown. Here we find that in adult male rats, presentation of a social stimulus (novel or familiar rat) or a novel object induces global remapping of place fields in CA2 with no effect on neuronal firing rate or immediate early gene expression. This remapping did not occur in CA1, suggesting this effect is specific for CA2. Thus, modification of existing spatial representations might be a potential mechanism by which CA2 encodes social and novel contextual information.
authors.affiliation: Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Mail Drop F2-04, Research Triangle Park, North Carolina 27709, USA.
authors.forename: Georgia M
authors.initials: GM
authors.lastname: Alexander
authors.affiliation: Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Mail Drop F2-04, Research Triangle Park, North Carolina 27709, USA.
authors.forename: Shannon
authors.initials: S
authors.lastname: Farris
authors.affiliation: Social and Scientific Systems, Inc., 1009 Slater Road Suite 120, Durham, North Carolina 27703, USA.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Pirone
authors.affiliation: Center for Learning and Memory, The University of Texas at Austin, 1 University Station Stop C7000, NMS 4.104, Austin, Texas 78712, USA.|Department of Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Chenguang
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Center for Learning and Memory, The University of Texas at Austin, 1 University Station Stop C7000, NMS 4.104, Austin, Texas 78712, USA.|Department of Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Colgin
authors.affiliation: Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Mail Drop F2-04, Research Triangle Park, North Carolina 27709, USA.
authors.forename: Serena M
authors.identifier: http://orcid.org/0000-0003-4094-8368
authors.initials: SM
authors.lastname: Dudek
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D056651:CA2 Region, Hippocampal / Q000502:physiology*; D008297:Male; D008568:Memory; D009474:Neurons / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D066107:Social Skills; D013028:Space Perception