title: Leprous neuromyositis: A rare clinical entity and review of the literature.
abstract: Mycobacterium leprae, the causative agent of leprosy (Hansen's disease), is a slow growing intracellular acid-fast bacillus that affects the skin, peripheral nerves and respiratory tract. In patients with suppressed cell-mediated immunity, the infiltration of the Bacilli can produce disseminated illness such as leprous neuromyositis. We reported a case of 56-year-old gentleman presenting with pyrexia of unknown origin, asymmetric sensory motor axonal polyneuropathy and was on chronic exogenous steroid therapy. On evaluation, his skin, muscle, nerve and bone marrow biopsy showed numerous globi of acid-fast Bacilli suggestive of leprous neuromyositis, a rare form of disseminated Hansen's disease. We reported this case in view of its rarity, atypical manifestation of a relatively rare disease and literature review on poor electrophysiological correlation in the diagnosis of leprous neuromyositis as compared to the histopathological examination.
authors.affiliation: Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Shubhanker
authors.initials: S
authors.lastname: Mitra
authors.forename: Karthik
authors.initials: K
authors.lastname: Gunasekaran
authors.forename: Geeta
authors.initials: G
authors.lastname: Chacko
authors.forename: Samuel George
authors.initials: SG
authors.lastname: Hansdak
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007918:Leprosy / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D009132:Muscles / Q000382:microbiology / Q000473:pathology; D009166:Mycobacterium leprae / Q000302:isolation & purification*; D009220:Myositis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D010525:Peripheral Nerves / Q000382:microbiology / Q000473:pathology; D012867:Skin / Q000382:microbiology / Q000473:pathology