title: [Multiple abscesses after a cruise along the Latin American coast].
abstract: We report a case of an extracutaneous involvement of pyoderma gangrenosum. The patient initially presented with multiple sterile abscesses of the skin, heart, prostate, and kidney. Extracutaneous involvement in pyoderma gangrenosum is very rare. Confirmation of the diagnosis was only possible after exclusion of other relevant differential diagnoses. Continuous search for microbes proved negative and after an empiric therapeutic attempt with prednisolone, the patient improved quickly. However, each time we reduced the steroids even in combination with methotrexate or with azathioprine the patient relapsed. Only after therapy with the tumor necrosis factor-α-inhibitor infliximab was permanent remission achieved.
authors.affiliation: I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Reynolds
authors.affiliation: Universitäres Herzzentrum Hamburg GmbH, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Schofer
authors.affiliation: Universitäres Herzzentrum Hamburg GmbH, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
authors.forename: E
authors.initials: E
authors.lastname: Zengin
authors.affiliation: I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
authors.forename: A W
authors.initials: AW
authors.lastname: Lohse
authors.affiliation: Gastroenterologie und Interventionelle Endoskopie, Viszeralmedizinisches Zentrum, Asklepios-Klinik Barmbek, Hamburg, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Faiss
authors.affiliation: I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland. s.schmiedel@uke.de.|Ambulanzzentrum, Bereich Infektiologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland. s.schmiedel@uke.de.
authors.forename: S
authors.initials: S
authors.lastname: Schmiedel
mesh_terms: D000038:Abscess / Q000175:diagnosis* / Q000188:drug therapy*; D000368:Aged; D003879:Dermatologic Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D006801:Humans; D000069285:Infliximab / Q000008:administration & dosage*; D007843:Latin America; D008297:Male; D017511:Pyoderma Gangrenosum / Q000175:diagnosis* / Q000188:drug therapy*; D014195:Travel; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D000069285:Infliximab
keywords: Abscess, sterile; Extracutaneous affection; Prednisolone; Pyoderma gangrenosum; Tumor necrosis factor-alpha, inhibitor