title: Risk factors for fatal outcome in surgical patients with postoperative aspiration pneumonia.
abstract: BACKGROUND
  Aspiration pneumonia in hospitalized surgical patients has been associated with a mortality of approximately 30%. The aim of this study was to assess pre-, intra- and postoperative risk factors for mortality in patients suffering aspiration pneumonia after abdominal surgery.
  
  
  METHODS
  Retrospective study from 01/2006-12/2012 of patients with clinically and radiologically confirmed aspiration pneumonia after abdominal surgery.
  
  
  RESULTS
  A total of 70 patients undergoing abdominal surgery and postoperative aspiration pneumonia were identified. There were 53 (76%) male patients, the mean age was 71 ± 12 years and the mean ASA score was 3 ± 1. The surgical procedures included 32 colorectal or small bowel resections, 10 partial liver resections, 9 gastric surgeries, 8 esophageal resections, 5 pancreatic surgeries, and 6 hernia repairs. Aspiration pneumonia occurred at mean postoperative day 7 ± 10. Overall, 53% (n = 37) of patients required re-intubation, with 4 ± 5 days of additional mechanical ventilation. Mean hospital and ICU length of stay was 32 ± 25 days and 6 ± 9 days, respectively. Overall mortality was 27% (n = 19). Forward logistic regression revealed older age [OR 7.41 (95% CI: 1.29-42.62)], bilateral aspiration pneumonia [OR 7.39 (95% CI: 1.86-29.29)] and intraoperative requirement of blood component transfusion [OR 5.09 (95% CI: 1.34-19.38)] as independent risk factors for mortality (overall R(2) = 0.336).
  
  
  CONCLUSIONS
  Postoperative aspiration pneumonia remains a severe complication with significant mortality. Increasing age, the need for intraoperative blood component transfusion and bilateral pulmonary infiltrates are independent risk factors for fatal outcome after aspiration pneumonia. Therefore, these patients suffering aspiration pneumonia require special attention and increased monitoring.
authors.affiliation: Department of Visceral Surgery and Medicine, Bern University Hospital, Bern, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Studer
authors.affiliation: Department of Visceral Surgery and Medicine, Bern University Hospital, Bern, Switzerland.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Räber
authors.affiliation: Department of Radiology, Bern University Hospital, Bern, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ott
authors.affiliation: Department of Visceral Surgery and Medicine, Bern University Hospital, Bern, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Candinas
authors.affiliation: Department of Visceral Surgery and Medicine, Bern University Hospital, Bern, Switzerland. Electronic address: beat.schnuriger@gmail.com.
authors.forename: Beat
authors.initials: B
authors.lastname: Schnüriger
mesh_terms: D000005:Abdomen / Q000601:surgery; D000367:Age Factors; D000368:Aged; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011015:Pneumonia, Aspiration / Q000209:etiology / Q000401:mortality*; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality*; D012189:Retrospective Studies; D012307:Risk Factors; D065227:Transfusion Reaction
keywords: Abdominal surgery; Aspiration pneumonia; Complication; Critical care