title: Cytotoxic tremulanes and 5,6-secotremulanes, four new sesquiterpenoids from a plant-associated fungus X1-2.
abstract: Two new tremulanes and two new 5,6-secotremulanes, davotremulanes A-D 1-4, along with four known compounds 5-8, were isolated from the culture extract of X1-2, an unidentified plant-associated fungus, which was isolated from the endangered plant, Davidia involucrate Baill. in Shennongjia District. The structures of new compounds 1-4 were established on the basis of extensive spectroscopic analysis. Compounds 1-8 were evaluated for cytotoxic activity to four cancer cell lines, and compounds 1, 2 and 5 displayed selectively moderate activities to A549 cell line with IC50at 15.3, 25.2, 35.2 μg/mL.
authors.affiliation: a Hubei Key Laboratory of Natural Product Research and Development, College of Biological and Pharmaceutical Sciences , China Three Gorges University , Yichang , PR China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Guo
authors.affiliation: a Hubei Key Laboratory of Natural Product Research and Development, College of Biological and Pharmaceutical Sciences , China Three Gorges University , Yichang , PR China.
authors.forename: Xueshuang
authors.initials: X
authors.lastname: Li
authors.affiliation: a Hubei Key Laboratory of Natural Product Research and Development, College of Biological and Pharmaceutical Sciences , China Three Gorges University , Yichang , PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a Hubei Key Laboratory of Natural Product Research and Development, College of Biological and Pharmaceutical Sciences , China Three Gorges University , Yichang , PR China.
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Feng
authors.affiliation: a Hubei Key Laboratory of Natural Product Research and Development, College of Biological and Pharmaceutical Sciences , China Three Gorges University , Yichang , PR China.
authors.forename: Zhangshuang
authors.initials: Z
authors.lastname: Deng
authors.affiliation: a Hubei Key Laboratory of Natural Product Research and Development, College of Biological and Pharmaceutical Sciences , China Three Gorges University , Yichang , PR China.
authors.forename: Haibo
authors.initials: H
authors.lastname: He
authors.affiliation: a Hubei Key Laboratory of Natural Product Research and Development, College of Biological and Pharmaceutical Sciences , China Three Gorges University , Yichang , PR China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zou
keywords: 5,6-secotremulanes; Tremulanes; cytotoxic activity; plant-associated fungus; secondary metabolites