title: Genomic variations in non-coding RNAs: Structure, function and regulation.
abstract: The last decade has seen tremendous improvements in the understanding of human variations and their association with human traits and diseases. The availability of high-resolution map of the human transcriptome and the discovery of a large number of non-protein coding RNA genes has created a paradigm shift in the understanding of functional variations in non-coding RNAs. Several groups in recent years have reported functional variations and trait or disease associated variations mapping to non-coding RNAs including microRNAs, small nucleolar RNAs and long non-coding RNAs. The understanding of the functional consequences of variations in non-coding RNAs has been largely restricted by the limitations in understanding the functionalities of the non-coding RNAs. In this short review, we outline the current state-of-the-art of the field with emphasis on providing a conceptual outline as on how variations could modulate changes in the sequence, structure, and thereby the functionality of non-coding RNAs.
authors.affiliation: GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India; Academy of Scientific & Innovative Research (AcSIR), Anusandhan Bhawan, New Delhi 110001, India.
authors.forename: Deeksha
authors.initials: D
authors.lastname: Bhartiya
authors.affiliation: GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India; Academy of Scientific & Innovative Research (AcSIR), Anusandhan Bhawan, New Delhi 110001, India.
authors.forename: Vinod
authors.initials: V
authors.lastname: Scaria
mesh_terms: D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D009690:Nucleic Acid Conformation; D020537:RNA, Small Nucleolar / Q000737:chemistry* / Q000235:genetics*
chemical_list: D020537:RNA, Small Nucleolar
keywords: Humans; Long non-coding RNAs; MicroRNAs; Non-coding RNAs; SnoRNAs; Variations