title: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with liver involvement.
abstract: BACKGROUND
  We examined outcomes of patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) combined with liver resection.
  
  
  METHODS
  All patients undergoing CRS/HIPEC between 2007 and 2014 were retrospectively reviewed: patients who underwent synchronous liver resection (group 1) were compared with those who did not (group 2) in terms of perioperative and long-term results.
  
  
  RESULTS
  Group 1 included 103 patients with colorectal cancer (CRC, n = 28), appendiceal cancer (n = 34), and other malignancies. Compared with group 2 (n = 166), group 1 had higher number of organs resected, increased intraoperative blood loss, and longer hospital stay (all P ≤ 0.004) but similar major morbidity (24.3% vs. 18.1%, P = 0.22) and perioperative mortality rates. Two patients from group 1 developed liver resection-related complications. A comparison between patients who underwent parenchymal liver resection (n = 42) and matched pairs from group 2 with similar extent of cytoreduction did not yield significant differences in morbidity/mortality. CRC patients from group 1 had poorer median overall survival (45.1 vs. 73.5 months from stage IV diagnosis, P = 0.009).
  
  
  CONCLUSIONS
  Liver involvement denotes high peritoneal carcinomatosis burden, which often requires resection of multiple organs in order to achieve optimal cytoreduction. However, liver resection-related morbidity is low and overall morbidity/mortality rates are comparable to other extensive CRS/HIPEC procedures. J. Surg. Oncol. 2016;113:432-437. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Mount Sinai Medical Center, New York, New York.
authors.forename: Yaniv
authors.initials: Y
authors.lastname: Berger
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Mount Sinai Medical Center, New York, New York.
authors.forename: Samantha
authors.initials: S
authors.lastname: Aycart
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Mount Sinai Medical Center, New York, New York.
authors.forename: Parissa
authors.initials: P
authors.lastname: Tabrizian
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Mount Sinai Medical Center, New York, New York.
authors.forename: Yahel
authors.initials: Y
authors.lastname: Agmon
authors.affiliation: Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York.
authors.forename: John
authors.initials: J
authors.lastname: Mandeli
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Mount Sinai Medical Center, New York, New York.
authors.forename: Marina
authors.initials: M
authors.lastname: Heskel
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Mount Sinai Medical Center, New York, New York.
authors.forename: Spiros
authors.initials: S
authors.lastname: Hiotis
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Mount Sinai Medical Center, New York, New York.
authors.forename: Umut
authors.initials: U
authors.lastname: Sarpel
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Mount Sinai Medical Center, New York, New York.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Labow
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007263:Infusions, Parenteral; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: cytoreductive surgery; hepatectomy; hyperthermic intraperitoneal chemotherapy; liver resection