title: The key role of rubella virus glycoproteins in the formation of immune response, and perspectives on their use in the development of new recombinant vaccines.
abstract: Rubella is a highly contagious viral disease which is mostly threatens to women of reproductive age. Existent live attenuated vaccines are effective enough, but have some drawbacks and are unusable for a certain group of people, including pregnant women and people with AIDS and other immunodeficiency. Thereby the development of alternative non-replicating, recombinant vaccines undoubtedly is needed. This review discusses the protein E1 and E2 role in formation of immune response and perspectives in development of new generation recombinant vaccines using them.
authors.affiliation: Faculty of Biology, Department of Virology, Lomonosov Moscow State University, 1/12 Leninskie Gory, Moscow 119234, Russia. Electronic address: petrova@mail.bio.msu.ru.
authors.forename: Ekaterina K
authors.initials: EK
authors.lastname: Petrova
authors.affiliation: Faculty of Biology, Department of Virology, Lomonosov Moscow State University, 1/12 Leninskie Gory, Moscow 119234, Russia.
authors.forename: Anastasia A
authors.initials: AA
authors.lastname: Dmitrieva
authors.affiliation: Faculty of Biology, Department of Virology, Lomonosov Moscow State University, 1/12 Leninskie Gory, Moscow 119234, Russia.
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Trifonova
authors.affiliation: Faculty of Biology, Department of Virology, Lomonosov Moscow State University, 1/12 Leninskie Gory, Moscow 119234, Russia.
authors.forename: Nikolai A
authors.initials: NA
authors.lastname: Nikitin
authors.affiliation: Faculty of Biology, Department of Virology, Lomonosov Moscow State University, 1/12 Leninskie Gory, Moscow 119234, Russia.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Karpova
mesh_terms: D000956:Antigens, Viral / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011994:Recombinant Proteins / Q000276:immunology; D012409:Rubella / Q000517:prevention & control*; D012411:Rubella Vaccine / Q000276:immunology*; D012412:Rubella virus; D014614:Vaccines, Synthetic / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D000939:Epitopes; D011994:Recombinant Proteins; D012411:Rubella Vaccine; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; C061826:E1 envelope protein, Rubella virus; C061827:E2 envelope protein, Rubella virus
keywords: Development of recombinant vaccines; Epitopes; Glycoproteins E1 and E2; Rubella virus