title: Etanercept for the treatment of non-radiographic axial spondyloarthritis.
abstract: Presently, tumor necrosis factor α antagonist therapy is the only effective alternative treatment to nonsteroidal anti-inflammatory drugs for the entire spectrum of axial spondyloarthritis, including non-radiographic and radiographic (=ankylosing spondylitis) forms. Recently, etanercept has been approved by the European Medicines Agency for the treatment of non-radiographic axial spondyloarthritis, increasing the number of available treatment options for this indication. The latest data on etanercept concerning clinical efficacy and safety in short-term and long-term treatment of patients with non-radiographic axial spondyloarthritis who do not respond to the first-line therapy with non-steroidal anti-inflammatory drugs suggests good efficacy and safety profiles similar to that observed previously in ankylosing spondylitis. This article reviews recent data on the efficacy and safety of etanercept and is focused on the treatment of non-radiographic axial spondyloarthritis. This article will also discuss the role of etanercept in the context of current and developing treatment options.
authors.affiliation: a Rheumatology, Med. Department I, Campus Benjamin Franklin , Charité Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Valeria
authors.initials: V
authors.lastname: Rios Rodriguez
authors.affiliation: a Rheumatology, Med. Department I, Campus Benjamin Franklin , Charité Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Denis
authors.initials: D
authors.lastname: Poddubnyy
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D000068800:Etanercept / Q000627:therapeutic use*; D006801:Humans; D025241:Spondylarthritis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D018501:Antirheumatic Agents; D000068800:Etanercept
keywords: Axial spondyloarthritis; ankylosing spondylitis; etanercept; non-radiographic axial spondyloarthritis; treatment; tumor necrosis factor (TNF) blockers