title: SURGICAL MANAGEMENT OF ADVANCED FAMILIAL EXUDATIVE VITREORETINOPATHY WITH COMPLICATIONS.
abstract: OBJECTIVE
  To report the management of complicated advanced familial exudative vitreoretinopathy in a predominantly young population.
  
  
  METHODS
  This retrospective study was performed on 34 eyes of 25 patients with severe complications of advanced familial exudative vitreoretinopathy, including retinal detachment, corneal opacity, shallow or flat anterior chamber, cataract, posterior pupillary adhesion, secondary glaucoma, vitreous hemorrhage, and preretinal hemorrhage. Preoperative and postoperative clinical information was reviewed.
  
  
  RESULTS
  The average age of the patients was 3.52 ± 5.94 years. Of the 34 eyes, 22 underwent lensectomy, 9 underwent lensectomy combined with vitrectomy, 2 underwent staged lensectomy and vitrectomy, and 1 underwent lens-sparing vitrectomy. After surgery, the shallow or flat anterior chamber became normal in 26/28 eyes; corneal opacity disappeared or improved in 10/22 eyes; and secondary glaucoma was controlled in 22/24 eyes. Among the 12 eyes operated by vitrectomy, the retina was attached in 5 eyes and partly attached in 7. Final visual acuity ranged from no light perception to 30/200 (n = 17). All 5 eyes with preoperative and postoperative visual acuity records showed improvement.
  
  
  CONCLUSIONS
  Surgical intervention is recommended to resolve complications of advanced familial exudative vitreoretinopathy and to preserve visual function. Staged lensectomy and vitrectomy is an alternative for advanced familial exudative vitreoretinopathy with corneal complications and/or vascularly active fibrovascular proliferation.
authors.affiliation: Xinhua Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Fei
authors.forename: Wenjie
authors.initials: W
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Haiying
authors.initials: H
authors.lastname: Jin
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Peiquan
authors.initials: P
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000867:Anterior Chamber / Q000473:pathology; D002386:Cataract / Q000209:etiology; D002387:Cataract Extraction; D002648:Child; D002675:Child, Preschool; D003318:Corneal Opacity / Q000209:etiology / Q000601:surgery; D005128:Eye Diseases / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D015785:Eye Diseases, Hereditary; D000080345:Familial Exudative Vitreoretinopathies; D005260:Female; D005451:Fluorescein Angiography; D005901:Glaucoma / Q000209:etiology / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D012163:Retinal Detachment / Q000209:etiology / Q000601:surgery; D012164:Retinal Diseases / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D012166:Retinal Hemorrhage / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy; D014823:Vitreous Hemorrhage / Q000209:etiology / Q000601:surgery; D055815:Young Adult