title: [Association between visual improvement after photocoagulation and the use of angiotensin converting enzyme inhibitors in diabetic macular oedema].
abstract: BACKGROUND
  Angiotensin converting enzyme inhibitors are effective in delaying the progression of diabetic retinopathy. It is unknown if their use is associated with a better visual outcome in patients with diabetic macular oedema.
  
  
  METHODS
  A non-experimental, comparative, longitudinal and retrospective study was performed on patients with diabetic macular oedema treated by focal photocoagulation, and with systemic arterial hypertension treated with angiotensin converting enzyme inhibitors (Group 1), and without hypertension (Group 2). The dependent variable was the proportion with visual improvement, operatively defined as the gain of one or more lines of vision three weeks after photocoagulation. The independent variable was the use of angiotensin converting enzyme inhibitors. The proportion of eyes with visual improvement after treatment was compared between groups using the Chi squared (χ(2)) test.
  
  
  RESULTS
  A total of 33 eyes (51.6%) were assigned to group 1, and 31 (48.2%), to group 2. The mean of visual acuity improved after three weeks, compared with baseline (p=0.002). The proportion of eyes with visual improvement did not differ between patients treated with angiotensin converting enzyme inhibitors (45.5%) and those that did not use them (51.6%, p=0.4).
  
  
  CONCLUSIONS
  There was no statistical difference in the proportion of eyes with visual improvement between patients treated with angiotensin converting enzyme inhibitors and in those where they were not used. There is no support for the inhibition of angiotensin II in addition to photocoagulation for improving the outcome in patients with diabetic macular oedema.
authors.affiliation: Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, D.F., México.
authors.forename: Selma Alin
authors.initials: SA
authors.lastname: Somilleda-Ventura
authors.affiliation: Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, D.F., México.
authors.forename: Yatzul Zuhaila
authors.initials: YZ
authors.lastname: García-Rubio
authors.affiliation: División de Investigación, Hospital Juárez de México, Secretaría de Salud, Ciudad de México, México.
authors.forename: Dulce Milagros
authors.initials: DM
authors.lastname: Razo Blanco-Hernández
authors.affiliation: Oftalmología, Hospital Juárez de México, Secretaría de Salud, Ciudad de México, México. Electronic address: vlimag@eninfinitum.com.
authors.forename: Virgilio
authors.initials: V
authors.lastname: Lima-Gómez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003930:Diabetic Retinopathy / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D017075:Laser Coagulation; D008269:Macular Edema / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents
keywords: Angiotensin converting enzyme inhibitors; Diabetic macular oedema; Diabetic retinopathy; Edema macular diabético; Focal photocoagulation; Fotocoagulación focal; Inhibidores de la enzima convertidora de angiotensina; Mejoría visual; Retinopatía diabética; Visual improvement