title: [Current status of castration-resistant prostate cancer translational research].
abstract: Recently, new drugs including abiraterone and enzalutamide have been able to be used for castration resistant prostate cancer(CRPC) patients. However, a subset of these patients who receive the new drugs does not response to the therapies. Furthermore, most patients who initially response to the drugs, progress to secondary resistance eventually. Therefore, it is important to investigate a novel therapeutic target and a novel treatment-selection marker for CRPC. In this review, we focused on AR-V7, TMPRSS2-ERG fusion gene and EP4 antagonist as representative translational researches.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maeno
authors.forename: Tomonori
authors.initials: T
authors.lastname: Habuchi
mesh_terms: D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism; D064129:Prostatic Neoplasms, Castration-Resistant / Q000235:genetics* / Q000473:pathology; D011944:Receptors, Androgen / Q000235:genetics; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors / Q000378:metabolism; D058309:Receptors, Prostaglandin E, EP4 Subtype / Q000037:antagonists & inhibitors; D057170:Translational Research, Biomedical / Q000379:methods
chemical_list: D015514:Oncogene Proteins, Fusion; D011944:Receptors, Androgen; D011965:Receptors, Glucocorticoid; D058309:Receptors, Prostaglandin E, EP4 Subtype; C515553:TMPRSS2-ERG fusion protein, human