title: Vacuolated lymphocytes signifying a metabolic disorder in an infant with developmental delay.
abstract: Metabolic disorders sometimes cause accumulation of metabolic byproducts which are manifested as cytoplasmic vacuoles in lymphocytes. We report the case of an infant with final diagnosis of GM1 gangliosidosis who initially presented with developmental delay and peripheral blood vacuolated lymphocytes. Blood film review is recommended in children suspicious for metabolic disorders.
authors.affiliation: Department of Pathology and Laboratory Medicine Indiana University Indianapolis IN 46202.
authors.forename: Rasha
authors.initials: R
authors.lastname: Salama
authors.affiliation: Department of Pathology and Laboratory Medicine Indiana University Indianapolis IN 46202.
authors.forename: Jiehao
authors.initials: J
authors.lastname: Zhou
keywords: Metabolic disorder; peripheral blood smear; vacuolated lymphocyte