title: ENDOTHELIAL DYSFUNCTION ASSESSED BY LASER DOPPLER POST-OCCLUSIVE HYPEREMIA IN CHRONIC KIDNEY DISEASE PATIENTS.
abstract: This study was intended to investigate the microcirculation endothelial dysfunction through a laser Doppler method (PORH post-occlusive reactive hyperemia) in patients with chronic kidney disease.
  
  
  METHODS
  The study included 299 patients diagnosed with chronic kidney disease, which were divided into three groups: hemodialysis patients, peritoneal dialysis patients and patients with chronic kidney disease stages 3-4. Endotelial dysfunction was assesed with the Laser Doppler Perfusion Monitor type device (Periflux System Monitor 5001).
  
  
  RESULTS
  The values of the parameters we evaluated with postocclusive reactive hyperemia were altered in all patients with chronic kidney disease. In the dialysis groups there was no statistically significant correlation between parameters we tested by measuring PORH and the method of renal replacement therapy or dialysis duration. The same was observed in patients with pre-dialysis chronic kidney disease.
  
  
  CONCLUSIONS
  Post-occlusive reactive hyperemia, a novel method for assessing endothelial dysfunction on the microcirculatory system and early marker of cardiovascular damage requires more studies to validate in patients advanced renal disfunction.
authors.forename: Irina
authors.initials: I
authors.lastname: Busila
authors.forename: Mihai
authors.initials: M
authors.lastname: Onofriescu
authors.forename: Angelica
authors.initials: A
authors.lastname: Gramaticu
authors.forename: Simona
authors.initials: S
authors.lastname: Hogas
authors.forename: Adrian
authors.initials: A
authors.lastname: Covic
authors.forename: Laura
authors.initials: L
authors.lastname: Florea
mesh_terms: D000328:Adult; D000368:Aged; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry / Q000379:methods; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011237:Predictive Value of Tests; D012016:Reference Values; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000503:physiopathology*; D012680:Sensitivity and Specificity