title: Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action.
abstract: Natural products have played a pivotal role in malaria chemotherapy progressing from quinine and artemisinin to ozonide-based compounds. Many of these natural products have served as template for the design and development of antimalarial drugs currently in the clinic or in the development phase. In this review, we will detail those privileged scaffolds that have guided medicinal chemistry efforts yielding molecules that have reached the clinic.
authors.affiliation: Diseases of the Developing World, Tres Cantos Medicines Development Campus, GlaxoSmithKline , c/Severo Ochoa, 2, 28760, Tres Cantos, Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Fernández-Álvaro
authors.affiliation: Robert Robinson Laboratories, Department of Chemistry, University of Liverpool , Crown Street, Liverpool L69 7ZD, U.K.
authors.forename: W David
authors.initials: WD
authors.lastname: Hong
authors.affiliation: Robert Robinson Laboratories, Department of Chemistry, University of Liverpool , Crown Street, Liverpool L69 7ZD, U.K.
authors.forename: Gemma L
authors.initials: GL
authors.lastname: Nixon
authors.affiliation: Robert Robinson Laboratories, Department of Chemistry, University of Liverpool , Crown Street, Liverpool L69 7ZD, U.K.
authors.forename: Paul M
authors.initials: PM
authors.lastname: O'Neill
authors.affiliation: Diseases of the Developing World, Tres Cantos Medicines Development Campus, GlaxoSmithKline , c/Severo Ochoa, 2, 28760, Tres Cantos, Madrid, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Calderón
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D015394:Molecular Structure
chemical_list: D000962:Antimalarials; D001688:Biological Products