title: Associations between matrix metalloproteinase gene polymorphisms and the development of cerebral infarction.
abstract: The aim of this study was to investigate the association between MMP3 rs3025058 and MMP9 rs3918242 polymorphisms and the development of ischemic stroke in a Chinese population. Between May 2013 and January 2015, 335 patients with ischemic stroke and 335 health control subjects were enrolled in this study. The MMP3 rs3025058 and MMP9 rs3918242 polymorphisms were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism. By multivariate logistic regression analysis, the CC genotype of MMP9 rs3918242 was shown to be associated with a significantly increased risk of ischemic stroke when compared with the TT genotype [OR (95%CI) = 5.47 (2.64-12.38)]. The TC+CC genotype of MMP9 rs3918242 was furthermore found to be associated with an elevated risk of ischemic stroke in higher BMI individuals [OR (95%CI) = 1.81 (1.03-3.22)]. The findings of this study suggest that the MMP9 rs3918242 polymorphism is associated with an elevated risk of ischemic stroke and that this gene polymorphism interacts with BMI in the risk of ischemic stroke.
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.|Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: J H
authors.initials: JH
authors.lastname: Zhao
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Xu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: H X
authors.initials: HX
authors.lastname: Xing
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: L L
authors.initials: LL
authors.lastname: Su
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: S B
authors.initials: SB
authors.lastname: Tao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Tian
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: H Q
authors.initials: HQ
authors.lastname: Yan
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors.forename: S B
authors.initials: SB
authors.lastname: Ji
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D015992:Body Mass Index; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9