title: Noncentrosomal microtubules in C. elegans epithelia.
abstract: The microtubule cytoskeleton has a dual contribution to cell organization. First, microtubules help displace chromosomes and provide tracks for organelle transport. Second, microtubule rigidity confers specific mechanical properties to cells, which are crucial in cilia or mechanosensory structures. Here we review the recently uncovered organization and functions of noncentrosomal microtubules in C. elegans epithelia, focusing on how they contribute to nuclear positioning and protein transport. In addition, we describe recent data illustrating how the microtubule and actin cytoskeletons interact to achieve those functions.
authors.affiliation: Development and Stem Cells Department, IGBMC - CNRS UMR 7104/INSERM U964/Université de Strasbourg, 1 Rue Laurent Fries, Illkirch, 67400, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Quintin
authors.affiliation: Development and Stem Cells Department, IGBMC - CNRS UMR 7104/INSERM U964/Université de Strasbourg, 1 Rue Laurent Fries, Illkirch, 67400, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Gally
authors.affiliation: Université Pierre Et Marie Curie, IBPS, CNRS UMR7622, 7 Quai St-Bernard, Paris, 75005, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Labouesse
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D021381:Protein Transport
chemical_list: D029742:Caenorhabditis elegans Proteins
keywords: adherens junctions; microtubule-actin interacting protein; nuclear positioning; recycling endosome; transport; tubulogenesis