title: Extinction of fear is facilitated by social presence: Synergism with prefrontal oxytocin.
abstract: This study addressed the question of whether extinction in pairs would have a beneficial effect on extinction of fear conditioning. To that end, we established an experimental setting for extinction in which we trained animals to extinguish contextual fear memory in pairs. Taking advantage of the role of oxytocin (OT) in the medial prefrontal cortex (mPFC) in the mediation of memory extinction and social interaction, we also sought to study its role in social interaction-induced effects on extinction. Our results clearly show that the social presence of another animal in the extinction context facilitates extinction, and that this facilitation is mediated through mPFC-OT. Our results suggest that social interaction may be a positive regulator of fear inhibition, implying that social interaction may be an easy, accessible therapeutic tool for the treatment of fear-associated disorders.
authors.affiliation: Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
authors.forename: Naama
authors.initials: N
authors.lastname: Brill-Maoz
authors.affiliation: Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel. Electronic address: mmaroun@psy.haifa.ac.il.
authors.forename: Mouna
authors.initials: M
authors.lastname: Maroun
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology; D005239:Fear / Q000523:psychology*; D008297:Male; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D010121:Oxytocin / Q000494:pharmacology* / Q000502:physiology; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012919:Social Behavior
chemical_list: D010121:Oxytocin
keywords: Extinction; Oxytocin; Prefrontal cortex; Rats; Social behavior