title: Optical coherence tomography (OCT) evaluation of intermediate coronary lesions in patients with NSTEMI.
abstract: BACKGROUND
  Coronary angiography is commonly performed following non-ST segment elevation myocardial infarction (NSTEMI) to assess the need for revascularization. Some of these patients have myocardial infarction (MI) with no obstructive coronary atherosclerosis (MINOCA). Patients without severe obstructive lesions are usually treated conservatively. However, coronary angiography has known limitations in the assessment of lesion severity. We report our experience of using coronary Optical Coherence Tomography (OCT) in a series of patients without severe obstructive coronary lesions.
  
  
  METHODS
  165 patients underwent coronary OCT at Vancouver General Hospital. NSTEMI was the clinical presentation in 70 patients and 26 had angiographically intermediate lesions with 40%-69% diameter stenosis. Prior to OCT image acquisition, intracoronary nitroglycerin 100-200μg was administered. Blood in the vessel was displaced using contrast media by manual injections.
  
  
  RESULTS
  OCT of the angiographically intermediate lesions showed larger minimal luminal area (MLA) than the angiographically severe lesions (MLA 3.3mm(2)±1.8mm(2) vs. 1.6mm(2)±0.6mm(2), p<0.001) and less severe % lumen area stenosis (54.2%±11.4% vs. 70.9%±6.8%, p=0.001). Plaque rupture or intracoronary thrombus was detected in 8/26 (31%) patients. PCI with stent deployment was performed in 16 patients (62%).
  
  
  CONCLUSIONS
  In stabilized patients with NSTEMI and angiographically intermediate disease, OCT examination confirmed the lack of severe anatomical stenosis in most patients. However, OCT also identified coronary lesions with unstable features. Further research is needed to help guide management of this subgroup of patients.
authors.affiliation: Stavanger University Hospital, Stavanger, Norway; Vancouver General Hospital, Vancouver, BC, Canada. Electronic address: nigussie.bogale@lyse.net.
authors.forename: Nigussie
authors.initials: N
authors.lastname: Bogale
authors.affiliation: Vancouver General Hospital, Vancouver, BC, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lempereur
authors.affiliation: Vancouver General Hospital, Vancouver, BC, Canada.
authors.forename: Imran
authors.initials: I
authors.lastname: Sheikh
authors.affiliation: Vancouver General Hospital, Vancouver, BC, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Wood
authors.affiliation: Vancouver General Hospital, Vancouver, BC, Canada.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Saw
authors.affiliation: Vancouver General Hospital, Vancouver, BC, Canada.
authors.forename: Anthony
authors.initials: A
authors.lastname: Fung
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D003328:Coronary Thrombosis / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072658:Non-ST Elevated Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012422:Rupture, Spontaneous; D012720:Severity of Illness Index; D015607:Stents; D041623:Tomography, Optical Coherence
keywords: Intermediate coronary lessions; NSTEMI; OCT