title: The 5-hydroxytryptamine4 receptor enables differentiation of informational content and encoding in the hippocampus.
abstract: Long-term synaptic plasticity, represented by long-term depression (LTD) and long-term potentiation (LTP) comprise cellular processes that enable memory. Neuromodulators such as serotonin regulate hippocampal function, and the 5-HT4 -receptor contributes to processes underlying cognition. It was previously shown that in the CA1-region, 5-HT4 -receptors regulate the frequency-response relationship of synaptic plasticity: patterned afferent stimulation that has no effect on synaptic strength (i.e., a θm-frequency), will result in LTP or LTD, when given in the presence of a 5-HT4 -agonist, or antagonist, respectively. Here, we show that in the dentate gyrus (DG) and CA3 regions of freely behaving rats, pharmacological manipulations of 5-HT4 -receptors do not influence responses generated at θm-frequencies, but activation of 5-HT4 -receptors prevents persistent LTD in mossy fiber (mf)-CA3, or perforant path-DG synapses. Furthermore, the regulation by 5-HT4 -receptors of LTP is subfield-specific: 5-HT4 -receptor-activation prevents mf-CA3-LTP, but does not strongly affect DG-potentiation. These data suggest that 5-HT4 -receptor activation prioritises information encoding by means of LTP in the DG and CA1 regions, and suppresses persistent information storage in mf-CA3 synapses. Thus, 5-HT4 -receptors serve to shape information storage across the hippocampal circuitry and specify the nature of experience-dependent encoding. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.
authors.affiliation: Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum, Germany.|International Graduate School of Neuroscience, Ruhr University Bochum, Bochum, Germany.
authors.forename: Hannah
authors.initials: H
authors.lastname: Twarkowski
authors.affiliation: Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum, Germany.
authors.forename: Hardy
authors.initials: H
authors.lastname: Hagena
authors.affiliation: Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum, Germany.|International Graduate School of Neuroscience, Ruhr University Bochum, Bochum, Germany.
authors.forename: Denise
authors.initials: D
authors.lastname: Manahan-Vaughan
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000378:metabolism*; D056654:CA3 Region, Hippocampal / Q000187:drug effects / Q000378:metabolism*; D018891:Dentate Gyrus / Q000187:drug effects / Q000378:metabolism*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000187:drug effects / Q000502:physiology*; D008297:Male; D019580:Perforant Pathway / Q000187:drug effects / Q000378:metabolism; D017208:Rats, Wistar; D044422:Receptors, Serotonin, 5-HT4 / Q000378:metabolism*; D058828:Serotonin 5-HT4 Receptor Agonists; D058832:Serotonin 5-HT4 Receptor Antagonists; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
chemical_list: D058828:Serotonin 5-HT4 Receptor Agonists; D058832:Serotonin 5-HT4 Receptor Antagonists; D044422:Receptors, Serotonin, 5-HT4
keywords: 5-HT4; LTD; LTP; dentate gyrus; mossy fibers