title: α,β-DIBROMOCHALCONE DERIVATIVES--SYNTHESIS AND ANTIMICROBIAL ACTIVITY.
abstract: OBJECTIVE
  To obtain some chalcones and their dibrominated analogues and to evaluate their antimicrobial potential.
  
  
  METHODS
  Eight chalcones were synthesized using the Claisen-Schmidt condensation of acetophenone/4-bromo-acetophenone and different benzaldehyde derivatives. These chalcones were further brominated using two different bromination agents: molecular bromine and pyridinium tribromide. The antimicrobial activity was tested using the disk diffusion method.
  
  
  CONCLUSIONS
  The classical bromination technique was compared to the eco-friendly one using pyridinium tribromide. Pyridinium tribromide bromination did not improve the reaction yields (except for one compound), but it had the advantage of being a stable, non-corrosive and non-toxic salt. The results of the antimicrobial assessment indicated that the bromination of the double bond slightly increased the antimicrobial potential in some cases, but the results obtained during the antimicrobial evaluation were modest, some of the derivatives being active especially on Sarcina lutea ATCC 9341 and Bacillus cereus ATCC 14579.
  
  
  CONCLUSIONS
  In this study, eight chalcones and their dibrominated analogues were synthesized, four of the α,β-dibromochalcones being reported for the first time. Pyridinium tribromide was used as an alternative for liquid bromine, the main advantage of this method being related to the reduced toxicity of the reagents. The synthesized compounds did not exhibit a very good antimicrobial potential.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Jităreanu
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Zbancioc
authors.forename: Cristina
authors.initials: C
authors.lastname: Tuchiluş
authors.forename: Mihaela
authors.initials: M
authors.lastname: Balan
authors.forename: Ursula
authors.initials: U
authors.lastname: Stănescu
authors.forename: Gabriela
authors.initials: G
authors.lastname: Tătărîngă
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects*; D001547:Benzaldehydes / Q000138:chemical synthesis / Q000737:chemistry; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D052978:Disk Diffusion Antimicrobial Tests; D054879:Halogenation; D006801:Humans; D011725:Pyridines; D012505:Sarcina / Q000187:drug effects*
chemical_list: D000098:Acetophenones; D000900:Anti-Bacterial Agents; D001547:Benzaldehydes; D047188:Chalcones; D011725:Pyridines; C038699:acetophenone; C032175:benzaldehyde