title: Serotonin 2a Receptor and Serotonin 1a Receptor Interact Within the Medial Prefrontal Cortex During Recognition Memory in Mice.
abstract: Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it. The serotonin 2a receptor (5-HT2aR) one of the principal post-synaptic receptors for 5-HT in the brain, is involved in neuropsychiatric and neurological disorders associated with memory deficits. Recognition memory can be defined as the ability to recognize if a particular event or item was previously encountered and is thus considered, under certain conditions, a form of episodic memory. As human data suggest that a constitutively decrease of 5-HT2A signaling might affect episodic memory performance we decided to compare the performance of mice with disrupted 5-HT2aR signaling (htr2a (-/-)) with wild type (htr2a (+/+)) littermates in different recognition memory and working memory tasks that differed in the level of proactive interference. We found that ablation of 5-HT2aR signaling throughout development produces a deficit in tasks that cannot be solved by single item strategy suggesting that 5-HT2aR signaling is involved in interference resolution. We also found that in the absence of 5-HT2aR signaling serotonin has a deleterious effect on recognition memory retrieval through the activation of 5-HT1aR in the medial prefrontal cortex.
authors.affiliation: Systems Neuroscience Group, Laboratory of Experimental Cognition and Behavior, Institute of Physiology and Biophysics, IFIBIO "Houssay," CONICET and University of Buenos Aires Medical School Buenos Aires, Argentina.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Morici
authors.affiliation: Systems Neuroscience Group, Laboratory of Experimental Cognition and Behavior, Institute of Physiology and Biophysics, IFIBIO "Houssay," CONICET and University of Buenos Aires Medical School Buenos Aires, Argentina.
authors.forename: Lucia
authors.initials: L
authors.lastname: Ciccia
authors.affiliation: Lyon Neuroscience Research Center, Centre National de la Recherche Scientifique UMR 5292 - Institut National de la Santé et de la Recherche Médicale U1028 - Université Claude Bernard Lyon1 Lyon, France.
authors.forename: Gaël
authors.initials: G
authors.lastname: Malleret
authors.affiliation: Sackler Institute for Developmental Psychobiology, Columbia University, New YorkNY, USA; New York State Psychiatric InstituteNew York, NY, USA.
authors.forename: Jay A
authors.initials: JA
authors.lastname: Gingrich
authors.affiliation: Laboratory of Memory Research and Molecular Cognition, Institute for Cell Biology and Neuroscience, CONICET and University of Buenos Aires Medical School Buenos Aires, Argentina.
authors.forename: Pedro
authors.initials: P
authors.lastname: Bekinschtein
authors.affiliation: Systems Neuroscience Group, Laboratory of Experimental Cognition and Behavior, Institute of Physiology and Biophysics, IFIBIO "Houssay," CONICET and University of Buenos Aires Medical School Buenos Aires, Argentina.
authors.forename: Noelia V
authors.initials: NV
authors.lastname: Weisstaub
keywords: 5-HT1A receptor; 5-HT2A receptor; interference control; recognition memory; serotonin