title: Lipid peroxidation is associated with poor control of type-2 diabetes mellitus.
abstract: BACKGROUND
  Hyperglycemia increases oxidative stress through the overproduction of reactive oxygen species, which results in an imbalance between free radicals and the antioxidant defense system of the cells. A positive correlation was reported between lipid peroxide levels and diabetic complication.
  
  
  OBJECTIVE
  The aim of the present study was to investigate the state of oxidative stress in controlled and uncontrolled diabetic patients.
  
  
  METHODS
  One hundred thirty nine participants were included in this study, grouped as: Group-I: Healthy Control group of non-diabetic normal subjects, Group-II: Controlled type-2 DM group of subjects with type-2 DM and HbA1c≤8% and Group-III: Uncontrolled type-2 DM group of subjects with type-2 DM and HbA1c>8%. Fasting blood glucose, 2h postprandial glucose, MDA and HbA1c were quantified. The association between diabetic control and lipid peroxidation (malondialdehyde) was evaluated.
  
  
  RESULTS
  The mean HbA1c increased significantly in uncontrolled type-2 DM subjects compared to controlled type-2 DM group. Lipid peroxidation as expressed in MDA was significantly increased in uncontrolled type-2 DM group compared to controlled type-2 DM, both groups show significant elevation in this parameter compared to healthy subjects. There is a significant positive correlation between MDA and HbA1c in the studied subjects.
  
  
  CONCLUSIONS
  The core problem during diabetes is poor glycemic control, which leads to protein glycation, lipid peroxidation, oxidative stress and ﬁnally varieties of complications. Periodic evaluation of lipid peroxidation products in diabetes mellitus is recommended as it could contribute to the early identiﬁcation and management of oxidative stress.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Umm Al-Qura University, K.S.A., Makkah, Saudi Arabia. Electronic address: Sameer_fatani2003@yahoo.co.uk.
authors.forename: Sameer Hassan
authors.initials: SH
authors.lastname: Fatani
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Umm Al-Qura University, K.S.A., Makkah, Saudi Arabia. Electronic address: atbabakr@uqu.edu.sa.
authors.forename: Abdullatif Taha
authors.initials: AT
authors.lastname: Babakr
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Umm Al-Qura University, K.S.A., Makkah, Saudi Arabia. Electronic address: emattia@uqu.edu.sa.
authors.forename: EssamEldin Mohamed
authors.initials: EM
authors.lastname: NourEldin
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Umm Al-Qura University, K.S.A., Makkah, Saudi Arabia. Electronic address: marzouki@uqu.edu.sa.
authors.forename: Abdalla A
authors.initials: AA
authors.lastname: Almarzouki
mesh_terms: D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D048909:Diabetes Complications / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D001786:Blood Glucose; D005609:Free Radicals; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Glycemic control; Lipid peroxidation; Malondialdehyde; Oxidative stress