title: Breast cancer in BRCA mutation carriers: medical treatment.
abstract: About 10% of breast cancers are associated with the inheritance of autosomal dominant breast cancer susceptibility alleles BRCA1 and BRCA2. Until recently, the medical management of BRCA mutation-associated breast cancer has not differed from that of the sporadic breast cancer counterpart. However, there is mounting evidence that this molecular alteration confers sensitivity or resistance to systemic therapies that can be exploited in terms of medical management. For example, studies support the use of platinum salts chemotherapy in BRCA mutated cancers. Moreover, a number of targeted therapies are showing activity in BRCA mutation carriers. Above all, BRCA defective tumor cells are particularly sensitive to Poly(ADP-ribose) polymerase (PARP) inhibitors. This review will summarize the state of the art of the medical treatment of breast cancer in BRCA mutation carriers, with a particular focus on chemotherapies and targeted therapies.
authors.affiliation: Investigative Clinical Oncology (INCO), Fondazione del Piemonte per l'Oncologia, Candiolo Cancer Institute (IRCCs), Turin, Italy - filippo.montemurro@ircc.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Milani
authors.forename: Elena
authors.initials: E
authors.lastname: Geuna
authors.forename: Giorgia
authors.initials: G
authors.lastname: Zucchini
authors.forename: Caterina
authors.initials: C
authors.lastname: Aversa
authors.forename: Rossella
authors.initials: R
authors.lastname: Martinello
authors.forename: Filippo
authors.initials: F
authors.lastname: Montemurro
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D058990:Molecular Targeted Therapy; D009154:Mutation
chemical_list: D000970:Antineoplastic Agents; D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human