title: Meta-analysis of drain amylase content on postoperative day 1 as a predictor of pancreatic fistula following pancreatic resection.
abstract: BACKGROUND
  Drain amylase content in the days immediately after major pancreatic resection has been investigated previously as a predictor of postoperative pancreatic fistula (POPF). Its accuracy, however, has not been determined conclusively. The purpose of this study was to evaluate the accuracy of drain amylase content on the first day after major pancreatic resection in predicting the occurrence of POPF.
  
  
  METHODS
  A literature search of the MEDLINE, Embase and Scopus(®) databases to 13 May 2015 was performed to identify studies evaluating the accuracy of drain amylase values on day 1 after surgery in predicting the occurrence of POPF. The area under the hierarchical summary receiver operating characteristic (ROC) curve (AUChSROC ) was calculated as an index of accuracy, and pooled estimates of accuracy indices (sensitivity and specificity) were calculated at different cut-off levels. Subgroup and meta-regression analyses were performed to test the robustness of the results.
  
  
  RESULTS
  Thirteen studies involving 4416 patients were included. The AUChSROC was 0·89 (95 per cent c.i. 0·86 to 0·92) for clinically significant POPF and 0·88 (0·85 to 0·90) for POPF of any grade. Pooled estimates of sensitivity and specificity were calculated for the different cut-offs: 90-100 units/l (0·96 and 0·54 respectively), 350 units/l (0·91 and 0·84) and 5000 units/l (0·59 and 0·91). Accuracy was independent of the type of operation, type of anastomosis performed and octreotide administration.
  
  
  CONCLUSIONS
  Evaluation of drain amylase content on the first day after surgery is highly accurate in predicting POPF following major pancreatic resection. It may allow early drain removal and institution of an enhanced recovery pathway.
authors.affiliation: Hepatopancreaticobiliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.
authors.forename: M C
authors.initials: MC
authors.lastname: Giglio
authors.affiliation: Hepatopancreaticobiliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.
authors.forename: D R C
authors.initials: DR
authors.lastname: Spalding
authors.affiliation: Hepatopancreaticobiliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.
authors.forename: A
authors.initials: A
authors.lastname: Giakoustidis
authors.affiliation: Hepatopancreaticobiliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.
authors.forename: A
authors.initials: A
authors.lastname: Zarzavadjian Le Bian
authors.affiliation: Hepatopancreaticobiliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.
authors.forename: L R
authors.initials: LR
authors.lastname: Jiao
authors.affiliation: Hepatopancreaticobiliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Habib
authors.affiliation: Hepatopancreaticobiliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.
authors.forename: M
authors.initials: M
authors.lastname: Pai
mesh_terms: D014943:Global Health; D006801:Humans; D015994:Incidence; D010180:Pancreatectomy / Q000009:adverse effects*; D010185:Pancreatic Fistula / Q000201:enzymology / Q000453:epidemiology / Q000209:etiology; D055292:Pancreatic alpha-Amylases / Q000378:metabolism*; D011183:Postoperative Complications / Q000175:diagnosis* / Q000201:enzymology; D011237:Predictive Value of Tests
chemical_list: D055292:Pancreatic alpha-Amylases