title: Are glucose levels, glucose variability and autonomic control influenced by inspiratory muscle exercise in patients with type 2 diabetes? Study protocol for a randomized controlled trial.
abstract: BACKGROUND
  Physical exercise reduces glucose levels and glucose variability in patients with type 2 diabetes. Acute inspiratory muscle exercise has been shown to reduce these parameters in a small group of patients with type 2 diabetes, but these results have yet to be confirmed in a well-designed study. The aim of this study is to investigate the effect of acute inspiratory muscle exercise on glucose levels, glucose variability, and cardiovascular autonomic function in patients with type 2 diabetes.
  
  
  METHODS
  This study will use a randomized clinical trial crossover design. A total of 14 subjects will be recruited and randomly allocated to two groups to perform acute inspiratory muscle loading at 2 % of maximal inspiratory pressure (PImax, placebo load) or 60 % of PImax (experimental load).
  
  
  CONCLUSIONS
  Inspiratory muscle training could be a novel exercise modality to be used to decrease glucose levels and glucose variability.
  
  
  BACKGROUND
  ClinicalTrials.gov NCT02292810 .
authors.affiliation: Exercise Pathophysiology Research Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. andressasilveiradeoliveira@yahoo.com.br.
authors.forename: Aso
authors.initials: A
authors.lastname: Schein
authors.affiliation: Exercise Pathophysiology Research Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. aninhacorrea.fst@gmail.com.|Faculty of Health Sciences, University of Sydney, Lidcombe, New South Wales, Australia. aninhacorrea.fst@gmail.com.
authors.forename: Aps
authors.initials: A
authors.lastname: Correa
authors.affiliation: Institute of Science and Technology, Universidade Federal de São Paulo, São Paulo, Brazil. rabello.casali@unifesp.br.
authors.forename: Karina Rabello
authors.initials: KR
authors.lastname: Casali
authors.affiliation: Exercise Pathophysiology Research Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. beatrizschaan@gmail.com.|Graduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. beatrizschaan@gmail.com.|Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. beatrizschaan@gmail.com.
authors.forename: Beatriz D
authors.initials: BD
authors.lastname: Schaan
mesh_terms: D001341:Autonomic Nervous System / Q000502:physiology*; D001786:Blood Glucose / Q000032:analysis*; D001945:Breathing Exercises; D002985:Clinical Protocols; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D017063:Outcome Assessment, Health Care
chemical_list: D001786:Blood Glucose