title: Clinical Data of Neonatal Systemic Thrombosis.
abstract: OBJECTIVE
  To evaluate clinical data and associated risk conditions of noncerebral systemic venous thromboembolism (VT), arterial thromboembolism (AT), and intracardiac thromboembolism (ICT) in neonates.
  
  
  METHODS
  Data analysis of first systemic thromboembolism occurring in 75 live neonates (0-28 days), enrolled in the Italian Registry of Pediatric Thrombosis from neonatology centers between January 2007 and July 2013.
  
  
  RESULTS
  Among 75 events, 41 (55%) were VT, 22 (29%) AT, and 12 (16%) ICT; males represented 65%, and 71% were preterm. In 19 (25%), thromboembolism was diagnosed on the first day of life. In this "early onset" group, prenatal-associated risk conditions (maternal/placental disease) were reported in 70% and inherited thrombophilia in 33%. Postnatal risk factors were present in 73%; infections and central vascular catheters in 56% and 54% VT, respectively, and in 67% ICT vs 27% AT (<.05). Overall mortality rate was 15% and significant thromboembolism-related sequelae were reported in 16% of discharged patients.
  
  
  CONCLUSIONS
  This report from the Registro Italiano Trombosi Infantili, although limited by representing an uncontrolled case series, can be used to develop future clinical trials on appropriate management and prevention of neonatal thrombosis, focusing on obstetrical surveillance and monitoring of critically ill neonates with vascular access. A thrombosis risk prediction rule specific for the neonatal population should be developed through prospective controlled studies.
authors.affiliation: Pediatric Hematology, Department of Pediatrics, University Hospital Città della Salute e della Scienza, Torino, Italy. Electronic address: paola.saracco@unito.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Saracco
authors.affiliation: Neonatal Intensive Care Unit, Department of Obstetrics and Neonatology, University Hospital Città della Salute e della Scienza, Torino, Italy.
authors.forename: Rossana
authors.initials: R
authors.lastname: Bagna
authors.affiliation: Department of Pediatrics, Dell'Angelo Hospital, Venezia, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Gentilomo
authors.affiliation: Neonatal Intensive Care Unit, Pediatrics, University Hospital of Padova, Padova, Italy.
authors.forename: Mariella
authors.initials: M
authors.lastname: Magarotto
authors.affiliation: Department of Pediatric Sciences, University Hospital Città della Salute e della Scienza, Torino, Italy.
authors.forename: Alice
authors.initials: A
authors.lastname: Viano
authors.affiliation: Neonatal Intensive Care Unit, Department of Obstetrics and Neonatology, University Hospital Città della Salute e della Scienza, Torino, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Magnetti
authors.affiliation: Pediatric Hematology and Oncology, University of Bari, Bari, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Giordano
authors.affiliation: Department of Hematology and Oncology and Transfusional Medicine, IRCCS Pediatric Hospital Bambin Gesù, Roma, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Luciani
authors.affiliation: Thrombosis and Hemostasis Unit, Giannina Gaslini Children Hospital, Genova, Italy.
authors.forename: Angelo Claudio
authors.initials: AC
authors.lastname: Molinari
authors.affiliation: Child Neurology Unit, Pediatric University Hospital of Padova, Padova, Italy.
authors.forename: Agnese
authors.initials: A
authors.lastname: Suppiej
authors.affiliation: Neonatal Intensive Care Unit, Giannina Gaslini Children Hospital, Genova, Italy.
authors.forename: Luca Antonio
authors.initials: LA
authors.lastname: Ramenghi
authors.affiliation: Department of Medicine, Coagulation Diseases Unit, University of Padova Medical School, Padova, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Simioni
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001158:Arteries / Q000473:pathology; D003326:Coronary Circulation; D003625:Data Collection; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D008297:Male; D015233:Models, Statistical; D009359:Neonatology / Q000379:methods; D010351:Patient Discharge; D012042:Registries; D012307:Risk Factors; D018805:Sepsis; D019851:Thrombophilia / Q000175:diagnosis* / Q000453:epidemiology; D054556:Venous Thromboembolism / Q000175:diagnosis* / Q000453:epidemiology
chemical_list: D000925:Anticoagulants