title: Circulating soluble receptor for advanced glycation end products is decreased and inversely associated with acute phase response in chronic spontaneous urticaria.
abstract: BACKGROUND
  Activation of receptor for advanced glycation end products (RAGE) leads to the proinflammatory response and the release of its soluble form (sRAGE) which appears to function as an anti-inflammatory feedback mechanism.
  
  
  OBJECTIVE
  To determine serum sRAGE concentration in CSU patients and its association with C-reactive protein (CRP) concentration, a nonspecific inflammatory marker of the disease activity.
  
  
  METHODS
  Concentrations of sRAGE and CRP were measured in serum of CSU patients and compared with the healthy controls.
  
  
  RESULTS
  Serum sRAGE concentrations were significantly decreased in CSU patients, especially those more severely affected. In addition, significant inverse correlations were observed between sRAGE and CRP concentrations.
  
  
  CONCLUSIONS
  Down-regulation of sRAGE and its association with acute phase response suggest a role for RAGE activation in the pathogenesis of CSU. It seems that lower serum sRAGE concentration may enhance the urticarial processes.
authors.affiliation: Department of Internal Diseases, Dermatology and Allergology in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. M. Curie-Skłodowskiej 10, 41-800, Zabrze, Poland. alakasperska@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Kasperska-Zajac
authors.affiliation: Department of Chemistry in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Damasiewicz-Bodzek
authors.affiliation: Department of Chemistry in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Tyrpień-Golder
authors.affiliation: Department of Gynaecology, Obstetrics and Oncological Gynaecology, SMDZ in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Zamlyński
authors.affiliation: Department of Internal Diseases, Dermatology and Allergology in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. M. Curie-Skłodowskiej 10, 41-800, Zabrze, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Grzanka
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood*; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood*; D012720:Severity of Illness Index; D012882:Skin Tests; D014581:Urticaria / Q000097:blood*
chemical_list: D000067759:Receptor for Advanced Glycation End Products; D002097:C-Reactive Protein
keywords: Acute phase response; C-reactive protein; Chronic spontaneous urticaria; Soluble receptor for advanced glycation end products