title: Candida albicans biofilms: development, regulation, and molecular mechanisms.
abstract: A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed communities of cells adhered to a surface. These biofilms are intrinsically resistant to conventional antifungal therapeutics, the host immune system, and other environmental factors, making biofilm-associated infections a significant clinical challenge. Here, we review current knowledge on the development, regulation, and molecular mechanisms of C. albicans biofilms.
authors.affiliation: Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, Merced, CA, USA.
authors.forename: Megha
authors.initials: M
authors.lastname: Gulati
authors.affiliation: Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, Merced, CA, USA. Electronic address: cnobile@ucmerced.edu.
authors.forename: Clarissa J
authors.initials: CJ
authors.lastname: Nobile
mesh_terms: D018441:Biofilms / Q000254:growth & development*; D002176:Candida albicans / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D014774:Virulence
keywords: Biofilm; Candida albicans; Fungi; Microbial community; Pathogen; Transcriptional regulation