title: Recent developments in the synthesis and utilization of chiral β-aminophosphine derivatives as catalysts or ligands.
abstract: In the last few years, the research area of chiral β-aminophosphines capable of promoting a wide range of diverse organic transformations has attracted more attention. Their derivatives constitute attractive reagents towards this end, due to their stability, low toxicity and ease of handling. These novel β-aminophosphine derivatives are potentially useful as organocatalysts and ligands in metal-catalysed reactions. In particular, chiral β-aminophosphines have recently emerged as powerful phosphine catalysts in asymmetric synthesis and catalysis. The asymmetric transformations to which metal complexes of these ligands have been applied include palladium-catalysed allylic substitutions and copper-catalysed 1,4-additions to enones among others. This review summarizes the most significant developments in the area of synthesis and application of chiral β-aminophosphine derivatives, providing a detailed overview of the current state of the art and including future aspects.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemsitry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, China. jlzhang@chem.ecnu.edu.cn.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemsitry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, China. jlzhang@chem.ecnu.edu.cn and State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, CAS, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Junliang
authors.initials: J
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D061565:Cycloaddition Reaction; D008024:Ligands; D008670:Metals / Q000737:chemistry; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D008670:Metals; D010720:Phosphines