title: Anthropometric findings from birth to adulthood and their relation with karyotpye distribution in Turkish girls with Turner syndrome.
abstract: To evaluate the anthropometric features of girls with Turner syndrome (TS) at birth and presentation and the effect of karyotype on these parameters. Data were collected from 842 patients with TS from 35 different centers, who were followed-up between 1984 and 2014 and whose diagnosis age ranged from birth to 18 years. Of the 842 patients, 122 girls who received growth hormone, estrogen or oxandrolone were excluded, and 720 girls were included in the study. In this cohort, the frequency of small for gestational age (SGA) birth was 33%. The frequency of SGA birth was 4.2% (2/48) in preterm and 36% (174/483) in term neonates (P < 0.001). The mean birth length was 1.3 cm shorter and mean birth weight was 0.36 kg lower than that of the normal population. The mean age at diagnosis was 10.1 ± 4.4 years. Mean height, weight and body mass index standard deviation scores at presentation were -3.1 ± 1.7, -1.4 ± 1.5, and 0.4 ± 1.7, respectively. Patients with isochromosome Xq were significantly heavier than those with other karyotype groups (P = 0.007). Age at presentation was negatively correlated and mid-parental height was positively correlated with height at presentation. Mid-parental height and age at presentation were the only parameters that were associated with height of children with TS. The frequency of SGA birth was found higher in preterm than term neonates but the mechanism could not be clarified. We found no effect of karyotype on height of girls with TS, whereas weight was greater in 46,X,i(Xq) and 45,X/46,X,i(Xq) karyotype groups.
authors.affiliation: Department of Pediatric Endocrinology, Gulhane Military Medicine Academy, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Sari
authors.affiliation: Department of Pediatric Endocrinology, Marmara University Faculty of Medicine, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Bereket
authors.affiliation: Department of Pediatric Endocrinology, Gulhane Military Medicine Academy, Turkey.
authors.forename: Ediz
authors.initials: E
authors.lastname: Yeşilkaya
authors.affiliation: Department of Pediatric Endocrinology, Istanbul University Istanbul Faculty of Medicine, Turkey.
authors.forename: Firdevs
authors.initials: F
authors.lastname: Baş
authors.affiliation: Department of Pediatric Endocrinology, Istanbul University Istanbul Faculty of Medicine, Turkey.
authors.forename: Rüveyde
authors.initials: R
authors.lastname: Bundak
authors.affiliation: Department of Pediatric Endocrinology, Istanbul University Istanbul Faculty of Medicine, Turkey.
authors.forename: Banu Küçükemre
authors.initials: BK
authors.lastname: Aydın
authors.affiliation: Department of Pediatric Endocrinology, Ege University Faculty of Medicine, Turkey.
authors.forename: Şükran
authors.initials: Ş
authors.lastname: Darcan
authors.affiliation: Department of Pediatric Endocrinology, İzmir Katip Çelebi University Faculty of Medicine, Turkey.
authors.forename: Bumin
authors.initials: B
authors.lastname: Dündar
authors.affiliation: Department of Pediatric Endocrinology, Konya Training and Research Hospital, Turkey.
authors.forename: Muammer
authors.initials: M
authors.lastname: Büyükinan
authors.affiliation: Department of Pediatric Endocrinology, 19 Mayıs University Faculty of Medicine, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Kara
authors.affiliation: Department of Pediatric Endocrinology, Kanuni Sultan Süleyman University Faculty of Medicine, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Adal
authors.affiliation: Department of Pediatric Endocrinology, İnönü University Faculty of Medicine, Turkey.
authors.forename: Ayşehan
authors.initials: A
authors.lastname: Akıncı
authors.affiliation: Department of Pediatric Endocrinology, Necmettin Erbakan University Faculty of Medicine, Turkey.
authors.forename: Mehmet Emre
authors.initials: ME
authors.lastname: Atabek
authors.affiliation: Department of Pediatric Endocrinology, Yıldırım Beyazıt University, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Demirel
authors.affiliation: Department of Pediatric Endocrinology, Gazi University Faculty of Medicine, Turkey.
authors.forename: Nurullah
authors.initials: N
authors.lastname: Çelik
authors.affiliation: Department of Pediatric Endocrinology, Dr. Behçet Uz Children Hospital, Turkey.
authors.forename: Behzat
authors.initials: B
authors.lastname: Özkan
authors.affiliation: Department of Pediatric Endocrinology, Pamukkale University Faculty of Medicine, Turkey.
authors.forename: Bayram
authors.initials: B
authors.lastname: Özhan
authors.affiliation: Department of Pediatric Endocrinology, Atatürk University Faculty of Medicine, Turkey.
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Orbak
authors.affiliation: Department of Pediatric Endocrinology, Celal Bayar University Faculty of Medicine, Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Ersoy
authors.affiliation: Department of Pediatric Endocrinology, Yüzüncü Yıl University Faculty of Medicine, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Doğan
authors.affiliation: Department of Pediatric Endocrinology, Harran University Faculty of Medicine, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ataş
authors.affiliation: Department of Pediatric Endocrinology, Marmara University Faculty of Medicine, Turkey.
authors.forename: Serap
authors.initials: S
authors.lastname: Turan
authors.affiliation: Department of Pediatric Endocrinology, Ege University Faculty of Medicine, Turkey.
authors.forename: Damla
authors.initials: D
authors.lastname: Gökşen
authors.affiliation: Department of Pediatric Endocrinology, Uludağ University Faculty of Medicine, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Tarım
authors.affiliation: Department of Pediatric Endocrinology, Çukurova University Faculty of Medicine, Turkey.
authors.forename: Bilgin
authors.initials: B
authors.lastname: Yüksel
authors.affiliation: Department of Pediatric Endocrinology, Istanbul University Cerrahpaşa Faculty of Medicine, Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Ercan
authors.affiliation: Department of Pediatric Endocrinology, Kocaeli University Faculty of Medicine, Turkey.
authors.forename: Şükrü
authors.initials: Ş
authors.lastname: Hatun
authors.affiliation: Department of Pediatric Endocrinology, Osmangazi University Faculty of Medicine, Turkey.
authors.forename: Enver
authors.initials: E
authors.lastname: Şimşek
authors.affiliation: Department of Pediatric Endocrinology, Karadeniz Technical University Faculty of Medicine, Turkey.
authors.forename: Ayşenur
authors.initials: A
authors.lastname: Ökten
authors.affiliation: Department of Pediatric Endocrinology, 9 Eylül University Faculty of Medicine, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Abacı
authors.affiliation: Department of Pediatric Endocrinology, Atatürk University Faculty of Medicine, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Döneray
authors.affiliation: Department of Pediatric Endocrinology, Diyarbakır Children's State Hospital, Turkey.
authors.forename: Mehmet Nuri
authors.initials: MN
authors.lastname: Özbek
authors.affiliation: Department of Pediatric Endocrinology, Gaziantep University Faculty of Medicine, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Keskin
authors.affiliation: Department of Pediatric Endocrinology, Kanuni Sultan Süleyman University Faculty of Medicine, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Önal
authors.affiliation: Department of Pediatric Endocrinology, Necmettin Erbakan University Faculty of Medicine, Turkey.
authors.forename: Nesibe
authors.initials: N
authors.lastname: Akyürek
authors.affiliation: Department of Pediatric Endocrinology, Yüzüncü Yıl University Faculty of Medicine, Turkey.
authors.forename: Kezban
authors.initials: K
authors.lastname: Bulan
authors.affiliation: Department of Pediatric Endocrinology, Yıldırım Beyazıt University, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Tepe
authors.affiliation: Department of Pediatric Endocrinology, Gazi University Faculty of Medicine, Turkey.
authors.forename: Hamdi Cihan
authors.initials: HC
authors.lastname: Emeksiz
authors.affiliation: Department of Pediatric Endocrinology, Dr. Behçet Uz Children Hospital, Turkey.
authors.forename: Korcan
authors.initials: K
authors.lastname: Demir
authors.affiliation: Department of Pediatric Endocrinology, Celal Bayar University Faculty of Medicine, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Kızılay
authors.affiliation: Department of Pediatric Endocrinology, Çukurova University Faculty of Medicine, Turkey.
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Topaloğlu
authors.affiliation: Department of Pediatric Endocrinology, Uludağ University Faculty of Medicine, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Eren
authors.affiliation: Department of Pediatric Endocrinology, Ege University Faculty of Medicine, Turkey.
authors.forename: Samim
authors.initials: S
authors.lastname: Özen
authors.affiliation: Department of Pediatric Endocrinology, Diyarbakır Children's State Hospital, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Demirbilek
authors.affiliation: Department of Pediatric Endocrinology, Marmara University Faculty of Medicine, Turkey.
authors.forename: Saygın
authors.initials: S
authors.lastname: Abalı
authors.affiliation: Department of Pediatric Endocrinology, Kanuni Sultan Süleyman University Faculty of Medicine, Turkey.
authors.forename: Leyla
authors.initials: L
authors.lastname: Akın
authors.affiliation: Department of Pediatric Endocrinology, Necmettin Erbakan University Faculty of Medicine, Turkey.
authors.forename: Beray Selver
authors.initials: BS
authors.lastname: Eklioğlu
authors.affiliation: Department of Pediatric Endocrinology, Yüzüncü Yıl University Faculty of Medicine, Turkey.
authors.forename: Sultan
authors.initials: S
authors.lastname: Kaba
authors.affiliation: Department of Pediatric Endocrinology, 9 Eylül University Faculty of Medicine, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Anık
authors.affiliation: Department of Pediatric Endocrinology, Marmara University Faculty of Medicine, Turkey.
authors.forename: Serpil
authors.initials: S
authors.lastname: Baş
authors.affiliation: Department of Pediatric Endocrinology, Kanuni Sultan Süleyman University Faculty of Medicine, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Unuvar
authors.affiliation: Department of Pediatric Endocrinology, Uludağ University Faculty of Medicine, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Sağlam
authors.affiliation: Department of Pediatric Endocrinology, Düzce University Faculty of Medicine, Turkey.
authors.forename: Semih
authors.initials: S
authors.lastname: Bolu
authors.affiliation: Department of Pediatric Endocrinology, Kanuni Sultan Süleyman University Faculty of Medicine, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Özgen
authors.affiliation: Department of Pediatric Endocrinology, Uludağ University Faculty of Medicine, Turkey.
authors.forename: Durmuş
authors.initials: D
authors.lastname: Doğan
authors.affiliation: Department of Pediatric Endocrinology, Uludağ University Faculty of Medicine, Turkey.
authors.forename: Esra Deniz
authors.initials: ED
authors.lastname: Çakır
authors.affiliation: Department of Pediatric Endocrinology, Selçuk University Faculty of Medicine, Turkey.
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Şen
authors.affiliation: Department of Pediatric Endocrinology, Yıldırım Beyazıt University, Turkey.|Department of Pediatric Endocrinology, Keçiören Training and Research Hospital, Turkey.
authors.forename: Nesibe
authors.initials: N
authors.lastname: Andıran
authors.affiliation: Department of Pediatric Endocrinology, Kocaeli University Faculty of Medicine, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Çizmecioğlu
authors.affiliation: Department of Pediatric Endocrinology, Istanbul University Cerrahpaşa Faculty of Medicine, Turkey.
authors.forename: Olcay
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authors.lastname: Evliyaoğlu
authors.affiliation: Department of Pediatric Endocrinology, Karadeniz Technical University Faculty of Medicine, Turkey.
authors.forename: Gülay
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authors.lastname: Karagüzel
authors.affiliation: Department of Pediatric Endocrinology, Süleyman Demirel University Faculty of Medicine, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Pirgon
authors.affiliation: Department of Pediatric Endocrinology, 9 Eylül University Faculty of Medicine, Turkey.
authors.forename: Gönül
authors.initials: G
authors.lastname: Çatlı
authors.affiliation: Department of Pediatric Endocrinology, Uludağ University Faculty of Medicine, Turkey.
authors.forename: Hatice Dilek
authors.initials: HD
authors.lastname: Can
authors.affiliation: Department of Pediatric Endocrinology, Çukurova University Faculty of Medicine, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Gürbüz
authors.affiliation: Department of Pediatric Endocrinology, Osmangazi University Faculty of Medicine, Turkey.
authors.forename: Çiğdem
authors.initials: Ç
authors.lastname: Binay
authors.affiliation: Department of Pediatric Endocrinology, Eskisehir Public Hospital, Turkey.
authors.forename: Veysel Nijat
authors.initials: VN
authors.lastname: Baş
authors.affiliation: Department of Pediatric Endocrinology, Gulhane Military Medicine Academy, Turkey.
authors.forename: Kürşat
authors.initials: K
authors.lastname: Fidancı
authors.affiliation: Department of Pediatric Endocrinology, Gulhane Military Medicine Academy, Turkey.
authors.forename: Davut
authors.initials: D
authors.lastname: Gül
authors.affiliation: Department of Pediatric Endocrinology, Gulhane Military Medicine Academy, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Polat
authors.affiliation: Department of Pediatric Endocrinology, Gulhane Military Medicine Academy, Turkey.
authors.forename: Cengizhan
authors.initials: C
authors.lastname: Acıkel
authors.affiliation: Department of Pediatric Endocrinology, Gazi University Faculty of Medicine, Turkey.
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinaz
authors.affiliation: Department of Pediatric Endocrinology, Istanbul University Istanbul Faculty of Medicine, Turkey.
authors.forename: Feyza
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authors.lastname: Darendeliler
mesh_terms: D059786:Abnormal Karyotype; D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010641:Phenotype; D014424:Turner Syndrome / Q000175:diagnosis* / Q000235:genetics*; D055815:Young Adult
keywords: anthropometry; karyotype; turner syndrome