title: Toxicokinetics of paraquat in Korean patients with acute poisoning.
abstract: To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit suicide and arrived at our hospital early, not later than 7 h after PQ ingestion. The urine dithionite test for PQ in all of the nine patients was strongly positive at emergency room. Blood samples were obtained every 30 min for the first 2~3 h and then every 1 or 2 h, as long as the clinical progression was stable among the patients for 30 h after PQ ingestion. The area under the plasma concentration-time curve (AUCinf), which was extrapolated to infinity, was calculated using the trapezoidal rule. Toxicokinetic parameters, such as the terminal elimination half-life, apparent oral clearance, and apparent volume of distribution (Vd/F) were calculated. The maximum PQ concentration (Cmax) and the time to reach maximum PQ concentration (Tmax) were also obtained. Plasma PQ concentrations in nine patients were well described by a bi-exponential curve with a mean terminal elimination half-life of 13.1±6.8 h. Cmax and AUCinf were 20.8±25.7 mg/l and 172.5±160.3 h·mg/l, respectively. Apparent volume of distribution and apparent oral clearance were 50.9±61.3 l/kg and 173.4±111.2 l/h, respectively. There were a significant correlation (r =0.84; p<0.05) between the PQ amount ingested and Cmax. AUCinf also showed a significant correlation (r =0.83; p<0.05) with the PQ amount ingested. These correlations provide evidence that PQ has dose-linear toxicokinetic characteristics.
authors.affiliation: Department of Clinical Pharmacology, Soonchunhyang University College of Medicine, Cheonan 31151, Korea.
authors.forename: Hak-Jae
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Clinical Pharmacology, Soonchunhyang University College of Medicine, Cheonan 31151, Korea.
authors.forename: Hyung-Ki
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Department of Clinical Pharmacology, Soonchunhyang University College of Medicine, Cheonan 31151, Korea.
authors.forename: Hwayoung
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Clinical Pharmacology, Soonchunhyang University College of Medicine, Cheonan 31151, Korea.
authors.forename: Jun-Seok
authors.initials: JS
authors.lastname: Bae
authors.affiliation: Department of Clinical Pharmacology, Soonchunhyang University College of Medicine, Cheonan 31151, Korea.
authors.forename: Jun-Tack
authors.initials: JT
authors.lastname: Kown
authors.affiliation: Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan 31151, Korea.
authors.forename: Hyo-Wook
authors.initials: HW
authors.lastname: Gil
authors.affiliation: Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan 31151, Korea.
authors.forename: Sae-Yong
authors.initials: SY
authors.lastname: Hong
keywords: Paraquat; Poisoning; Toxicokinetics