title: Effect of a high and low dose of caffeine on human lymphocyte activation in response to antigen stimulation.
abstract: This study investigated the effect of caffeine on antigen-stimulated lymphocyte activation. Six males rested for 3.5 h after ingesting 0 (PLA), 2, or 6 (6CAF) mg·kg(-1) body mass of caffeine. The number of antigen-stimulated NK CD69(+) cells increased in 6CAF at 1 h compared with PLA (P = 0.021). Caffeine did not influence the number of antigen-stimulated CD69(+) T cells or the geometric mean fluorescence intensity expression of CD69 on antigen-stimulated lymphocytes, suggesting caffeine has little effect on antigen-stimulated lymphocyte activation.
authors.affiliation: a AUT University, Sports Performance Research Institute New Zealand, Private Bag 92006, Auckland 1020, New Zealand.
authors.forename: Deborah K
authors.initials: DK
authors.lastname: Dulson
authors.affiliation: b School of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK.
authors.forename: Nicolette C
authors.initials: NC
authors.lastname: Bishop
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D002110:Caffeine / Q000008:administration & dosage*; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000276:immunology*; D008297:Male; D000099192:CD69 Antigens
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D002110:Caffeine; D037181:Lectins, C-Type; D000099192:CD69 Antigens
keywords: CD69; NK cell; T cell; caffeine; caféine; cellules NK; cellules T; immune; lymphocytes; methylxanthine; méthylxanthine