title: Absence of seizures in Rasmussen encephalitis with active inflammation.
abstract: Severe focal motor epilepsy is considered a clinical hallmark of Rasmussen encephalitis (RE). The authors report a 6-year-old girl with progressive right sided hemiparesis, loss of language skills, left sided hemispheric atrophy, and brain pathologic features characteristic for RE. The patient did not experience seizures over a 2year period after symptom onset and for several months during follow-up. This report expands the clinical spectrum of RE and suggests that seizures are not a universal symptom of RE. Our patient's quite remarkable neurologic deficits along with active inflammation in the absence of epilepsy supports that, at least in some individuals, unilateral hemispheric progressive inflammation can occur without active seizure activity.
authors.affiliation: Neurology Section, Department of Pediatrics, University of Arkansas for Medical Sciences, 1 Children's Way, Little Rock, AR 72202, USA. Electronic address: dsamanta@uams.edu.
authors.forename: Debopam
authors.initials: D
authors.lastname: Samanta
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Murat
authors.initials: M
authors.lastname: Gokden
authors.affiliation: Division of Neurosurgery, Arkansas Children's Hospital, and Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Albert
mesh_terms: D002648:Child; D004660:Encephalitis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis; D012640:Seizures / Q000175:diagnosis*
keywords: Hemispheric atrophy; Inflammation; Progressive hemiparesis; Rasmussen encephalitis