title: [A Case of General Anesthesia in a Patient with Spinal and Bulbar Muscular Atrophy].
abstract: We report a successful management of anesthesia in a 55-year-old male patient with spinal and bulbar muscular atrophy (SBMA). His respiratory and swallowing functions were preserved preoperatively. He underwent an osteosynthesis for a femoral neck fracture under general anesthesia using nondepolarizing muscle relaxant. The anesthetic concerns in patients with SBMA are the possibility of postoperative respiratory dysfunction due to anesthetics or muscle relaxants and that of postoperative neurological deterioration due to spinal or epidural anesthesia. In this case, the effect of an intubating dose of rocuronium (0.5 mg · kg(-1)) was markedly prolonged, but it was completely reversed by sugammadex (2 mg · kg(-1)). Postoperative course was uneventful and clinical symptoms of SBMA did not become exacerbated.
authors.forename: Mika
authors.initials: M
authors.lastname: Kumakura
authors.forename: Koji
authors.initials: K
authors.lastname: Hara
authors.forename: Goh
authors.initials: G
authors.lastname: Obara
authors.forename: Takeyoshi
authors.initials: T
authors.lastname: Sata
mesh_terms: D000732:Androstanols / Q000008:administration & dosage / Q000494:pharmacology*; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D004338:Drug Combinations; D005265:Femoral Neck Fractures / Q000150:complications / Q000601:surgery*; D005593:Fracture Fixation, Internal; D006801:Humans; D008297:Male; D008875:Middle Aged; D009134:Muscular Atrophy, Spinal / Q000150:complications*; D020966:Muscular Disorders, Atrophic / Q000150:complications*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D004338:Drug Combinations; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium