title: Review: Animal model and the current understanding of molecule dynamics of adipogenesis.
abstract: Among several potential animal models that can be used for adipogenic studies, Wagyu cattle is the one that presents unique molecular mechanisms underlying the deposit of substantial amounts of intramuscular fat. As such, this review is focused on current knowledge of such mechanisms related to adipose tissue deposition using Wagyu cattle as model. So abundant is the lipid accumulation in the skeletal muscles of these animals that in many cases, the muscle cross-sectional area appears more white (adipose tissue) than red (muscle fibers). This enhanced marbling accumulation is morphologically similar to that seen in numerous skeletal muscle dysfunctions, disease states and myopathies; this might indicate cross-similar mechanisms between such dysfunctions and fat deposition in Wagyu breed. Animal models can be used not only for a better understanding of fat deposition in livestock, but also as models to an increased comprehension on molecular mechanisms behind human conditions. This revision underlies some of the complex molecular processes of fat deposition in animals.
authors.affiliation: 1Department of Animal Sciences,Universidade Federal de Viçosa,Viçosa, MG 36570-000,Brazil.
authors.forename: C F
authors.initials: CF
authors.lastname: Campos
authors.affiliation: 1Department of Animal Sciences,Universidade Federal de Viçosa,Viçosa, MG 36570-000,Brazil.
authors.forename: M S
authors.initials: MS
authors.lastname: Duarte
authors.affiliation: 1Department of Animal Sciences,Universidade Federal de Viçosa,Viçosa, MG 36570-000,Brazil.
authors.forename: S E F
authors.initials: SE
authors.lastname: Guimarães
authors.affiliation: 1Department of Animal Sciences,Universidade Federal de Viçosa,Viçosa, MG 36570-000,Brazil.
authors.forename: L L
authors.initials: LL
authors.lastname: Verardo
authors.affiliation: 4College of Animal Science and Technology,Nanjing Agricultural University,Nanjing,Jiangsu 210095,PR China.
authors.forename: S
authors.initials: S
authors.lastname: Wei
authors.affiliation: 2Department of Animal Sciences,Washington State University,Pullman,WA 99164,USA.
authors.forename: M
authors.initials: M
authors.lastname: Du
authors.affiliation: 2Department of Animal Sciences,Washington State University,Pullman,WA 99164,USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: 5Department of Animal Sciences,Auburn University,Auburn,AL 36849-5415,USA.
authors.forename: W G
authors.initials: WG
authors.lastname: Bergen
authors.affiliation: 6Department of Animal and Dairy Science,University of Georgia,Athens,GA 30602,USA.
authors.forename: G J
authors.initials: GJ
authors.lastname: Hausman
authors.affiliation: 7Albitec Corporation,Columbus,OH 43215,USA.
authors.forename: M
authors.initials: M
authors.lastname: Fernyhough-Culver
authors.affiliation: 8Leibniz Institute for Farm Animal Biology,Wilhelm-Stahl-Allee 2,18196 Dummerstorf,Germany.
authors.forename: E
authors.initials: E
authors.lastname: Albrecht
authors.affiliation: 2Department of Animal Sciences,Washington State University,Pullman,WA 99164,USA.
authors.forename: M V
authors.initials: MV
authors.lastname: Dodson
mesh_terms: D050156:Adipogenesis / Q000502:physiology*; D000273:Adipose Tissue / Q000033:anatomy & histology / Q000378:metabolism*; D000818:Animals; D002417:Cattle / Q000145:classification / Q000378:metabolism*; D006801:Humans; D058751:Livestock / Q000033:anatomy & histology / Q000378:metabolism; D023421:Models, Animal; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000378:metabolism
keywords: adipogenesis; lipodystrophies; obesity; wagyu