title: The consequences of physical post-treatments (microwave and electron-beam) on food/packaging interactions: A physicochemical and toxicological approach.
abstract: The safety of microwave and electron-beam treatments has been demonstrated, in regards to the formation of reaction products that could endanger human health. An integrated approach was used combining the potential toxicity of all the substances likely to migrate to their chemical characterizations. This approach was applied to polypropylene (PP) films prepared with a selection of additives. Components were identified by liquid and gas chromatography using a mass selective detector system. Their potential toxicity was assessed using three in vitro short-term bioassays and their migrations were carried out using a standards-based approach. After the electron-beam treatment some additives decomposed and there was a significant increase in the polyolefin oligomeric saturated hydrocarbons concentration. PP prepared with Irgafos 168 led to a significantly strong cytotoxic effect and PP prepared with Irganox 1076 induced a dose-dependant estrogenic effect in vitro. Migration values were low and below the detection limit of the analytical method applied.
authors.affiliation: AgroParisTech, Ingénierie Procédés Aliments, UMR1145, Massy, France; INRA, Ingénierie Procédés Aliments, UMR1145, Massy, France. Electronic address: anne-marie.riquet@agroparistech.fr.
authors.forename: A M
authors.initials: AM
authors.lastname: Riquet
authors.affiliation: CASIMIR, Pôle Technologique d'Auvergne, Aubière, France.
authors.forename: C
authors.initials: C
authors.lastname: Breysse
authors.affiliation: Université de Bourgogne, INSERM U866, Derttech "Packtox", Dijon, France.
authors.forename: L
authors.initials: L
authors.lastname: Dahbi
authors.affiliation: LNE, Trappes, France.
authors.forename: C
authors.initials: C
authors.lastname: Loriot
authors.affiliation: Université de Bourgogne, INSERM U866, Derttech "Packtox", Dijon, France.
authors.forename: I
authors.initials: I
authors.lastname: Severin
authors.affiliation: Université de Bourgogne, INSERM U866, Derttech "Packtox", Dijon, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Chagnon
mesh_terms: D004583:Electrons / Q000009:adverse effects*; D018857:Food Packaging; D059022:Food Safety; D006801:Humans; D008872:Microwaves / Q000009:adverse effects*; D011126:Polypropylenes / Q000737:chemistry*
chemical_list: D011126:Polypropylenes
keywords: Bioassays; By-product components; Electron-beam; Food packaging; Food safety; Microwave; Migration