title: The Effect of Perioperative Ischemia and Reperfusion on Multiorgan Dysfunction following Abdominal Aortic Aneurysm Repair.
abstract: Abdominal aortic aneurysms (AAAs) are relatively common and are potentially life-threatening medical problems. The aim of this review is to provide an overview of the effect of I/R injury on multiorgan failure following AAA repair. The PubMed, CINAHL, EMBASE, Medline, Cochrane Review, and Scopus databases were comprehensively searched for articles concerning the pathophysiology of I/R and its systemic effects. Cross-referencing was performed using the bibliographies from the articles obtained. Articles retrieved were restricted to those published in English. One of the most prominent characteristics of AAA open repair is the double physiological phenomenon of ischemia-reperfusion (I/R) that happens either at the time of clamping or following the aortic clamp removal. Ischemia-reperfusion injury causes significant pathophysiological disturbances to distant organs, increasing the possibility for postoperative multiorgan failure. Although tissue injury is mediated by diverse mechanisms, microvascular dysfunction seems to be the final outcome of I/R.
authors.affiliation: Vascular Surgery Unit, 2nd Surgical Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Konstantina
authors.initials: K
authors.lastname: Katseni
authors.affiliation: MSc "Cardiopulmonary Resuscitation", Medical School, National and Kapodistrian University of Athens, Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece; Department of Anesthesiology, Tzaneio Hospital of Piraeus, Piraeus, Greece.
authors.forename: Athanasios
authors.identifier: 0000-0002-7634-4665
authors.initials: A
authors.lastname: Chalkias
authors.affiliation: Vascular Surgery Unit, 2nd Surgical Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kotsis
authors.affiliation: Vascular Surgery Unit, 2nd Surgical Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Dafnios
authors.affiliation: Vascular Surgery Unit, 2nd Surgical Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Arapoglou
authors.affiliation: Department of Biopathology, Aretaion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Kaparos
authors.affiliation: Department of Biopathology, Aretaion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Logothetis
authors.affiliation: Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece; Neonatal Division, Department of Pediatrics, Aretaion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Nicoletta
authors.identifier: 0000-0001-8021-6191
authors.initials: N
authors.lastname: Iacovidou
authors.affiliation: Department of Biopathology, Aretaion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Karvouni
authors.affiliation: Vascular Surgery Unit, 2nd Surgical Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Katsenis
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D011183:Postoperative Complications / Q000503:physiopathology; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology / Q000503:physiopathology