title: Biocompatibility and antibacterial activity of the Adathoda vasica Linn extract mediated silver nanoparticles.
abstract: The aim of this study is to investigate the biocompatibility and anti-Vibrio efficacy of green synthesized silver nanoparticles (AgNPs) using an aqueous leaf extract of Adathoda vasica (A. vasica). The green synthesized silver nanoparticles were characterized by UV-vis, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). A. vasica AgNPs showed significant antibacterial activity against Vibrio parahaemolyticus in agar bioassay and well diffusion method. Further, nanoparticles interactions with bacteria and its antibacterial activity were confirmed by CLSM analysis. In vivo evaluation results confirmed that synthesized A. vasica AgNPs had good antibacterial efficacy and also nontoxic to the Artemia nauplii.
authors.affiliation: Department of Animal Health and Management, Alagappa University, Karaikudi 630 004, India.
authors.forename: M
authors.initials: M
authors.lastname: Latha
authors.affiliation: Department of Animal Health and Management, Alagappa University, Karaikudi 630 004, India.
authors.forename: M
authors.initials: M
authors.lastname: Priyanka
authors.affiliation: Department of Animal Health and Management, Alagappa University, Karaikudi 630 004, India.
authors.forename: P
authors.initials: P
authors.lastname: Rajasekar
authors.affiliation: Department of Zoology, University of Madras, Guindy Campus, Chennai 600 025, India.
authors.forename: R
authors.initials: R
authors.lastname: Manikandan
authors.affiliation: Department of Animal Health and Management, Alagappa University, Karaikudi 630 004, India. Electronic address: 71gnmprabhu@gmail.com.
authors.forename: N M
authors.initials: NM
authors.lastname: Prabhu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D027902:Justicia / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D012834:Silver / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D014736:Vibrio parahaemolyticus / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D012834:Silver
keywords: Adathoda vasica; Antibacterial activity; Artemia; Vibrio parahaemolyticus