title: Blastocoele expansion degree predicts live birth after single blastocyst transfer for fresh and vitrified/warmed single blastocyst transfer cycles.
abstract: OBJECTIVE
  To evaluate the independent effects of the degree of blastocoele expansion and re-expansion and the inner cell mass (ICM) and trophectoderm (TE) grades on predicting live birth after fresh and vitrified/warmed single blastocyst transfer.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Reproductive medical center.
  
  
  METHODS
  Women undergoing 844 fresh and 370 vitrified/warmed single blastocyst transfer cycles.
  
  
  METHODS
  None.
  
  
  METHODS
  Live-birth rate correlated with blastocyst morphology parameters by logistic regression analysis and Spearman correlations analysis.
  
  
  RESULTS
  The degree of blastocoele expansion and re-expansion was the only blastocyst morphology parameter that exhibited a significant ability to predict live birth in both fresh and vitrified/warmed single blastocyst transfer cycles respectively by multivariate logistic regression and Spearman correlations analysis. Although the ICM grade was significantly related to live birth in fresh cycles according to the univariate model, its effect was not maintained in the multivariate logistic analysis. In vitrified/warmed cycles, neither ICM nor TE grade was correlated with live birth by logistic regression analysis.
  
  
  CONCLUSIONS
  This study is the first to confirm that the degree of blastocoele expansion and re-expansion is a better predictor of live birth after both fresh and vitrified/warmed single blastocyst transfer cycles than ICM or TE grade.
authors.affiliation: Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Du
authors.affiliation: Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: En-Yin
authors.initials: EY
authors.lastname: Wang
authors.affiliation: Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Guo
authors.affiliation: Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Yu-Jing
authors.initials: YJ
authors.lastname: Xiong
authors.affiliation: Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Yu
authors.affiliation: Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Gui-Dong
authors.initials: GD
authors.lastname: Yao
authors.affiliation: Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Sen-Lin
authors.initials: SL
authors.lastname: Shi
authors.affiliation: Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China. Electronic address: syp2008@vip.sina.com.
authors.forename: Ying-Pu
authors.initials: YP
authors.lastname: Sun
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000502:physiology*; D004624:Embryo Transfer / Q000379:methods / Q000639:trends*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth / Q000453:epidemiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies; D056826:Single Embryo Transfer / Q000379:methods / Q000639:trends; D058989:Vitrification
keywords: ART; Blastocyst morphology; blastocoele expansion degree; live birth; single blastocyst transfer