title: [Carotid intima-media thickness distribution according to the stratification of cardiovascular risk by means of Framingham-REGICOR and score function charts].
abstract: BACKGROUND
  Carotid intima-media thickness (cIMT) has been suggested as a further tool for risk function charts. The aim of this study was to describethe relationship between cIMT and cardiovascular risk (CVR) estimation according to Framingham-REGICOR and SCORE equations.
  
  
  METHODS
  Observational, cross-sectional cohort study from 362 hypertensive subjects. Demographic and clinical information were collected as well as laboratory, ultrasonographic and CVR estimation by the Framingham-REGICOR and SCORE functions. Statistical analysis was performed using SPSS software (version 20,0). To analyze the data, statistical tests such as Chi-square, T-test, ANOVA, and Pearson correlation coefficient were used.
  
  
  RESULTS
  According to both functions, differences on mean cIMT were found between low CVR group and intermediate to high groups. No differences were found between intermediate and high risk groups (cIMT: 0,73mm low risk patients vs. 0,89 or 0,88mm respectively according to SCORE function and cIMT: 0,73 vs. 0,85 or 0,87mm respectively according to Framingham-REGICOR function). cIMT correlated positively with CVR estimation according to both SCORE (r=0,421; P<.01), and Framingham-REGICOR functions (r=0,363; P<.01).
  
  
  CONCLUSIONS
  cIMT correlates positively with CVR estimated by SCORE and Framingham-REGICOR functions. cIMT in those subjects at intermediate risk is similar to those at high risk. Our findings highlight the importance of carotid ultrasound in identifying silent target-organ damage in those patients at intermediate CVR.
authors.affiliation: Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital Clínico Universitario, Santiago de Compostela (La Coruña), España. Electronic address: alvaro.hermida.ameijeiras@sergas.es.
authors.forename: Á
authors.initials: Á
authors.lastname: Hermida-Ameijeiras
authors.affiliation: Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital Clínico Universitario, Santiago de Compostela (La Coruña), España.
authors.forename: J E
authors.initials: JE
authors.lastname: López-Paz
authors.affiliation: Departamento de Análisis Clínicos, Laboratorio Central, Hospital Clínico Universitario, Santiago de Compostela (La Coruña), España.
authors.forename: M A
authors.initials: MA
authors.lastname: Riveiro-Cruz
authors.affiliation: Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital Clínico Universitario, Santiago de Compostela (La Coruña), España.
authors.forename: C
authors.initials: C
authors.lastname: Calvo-Gómez
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002339:Carotid Arteries; D059168:Carotid Intima-Media Thickness; D016009:Chi-Square Distribution; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006801:Humans; D006973:Hypertension; D018570:Risk Assessment; D012307:Risk Factors
keywords: Cardiovascular risk; Framingham-REGICOR; Grosor íntima-media carotídeo; Hipertensión arterial; Hypertension; Intima-media thickness; Riesgo cardiovascular; SCORE; SCORE function