title: Obesity and cancer: An update of the global impact.
abstract: In view of the growing global obesity epidemic, this paper reviews the relation between recent trends in body mass index (BMI) and the changing profile of cancer worldwide. By examining seven selected countries, each representing a world region, a pattern of increasing BMI with region and gender-specific diversity is noted: increasing levels of BMI were most pronounced in the Middle East (Saudi Arabia), rather modest in Eastern Asia (India) and generally more rapid in females than in males. This observation translates into a disproportionate distribution of cancer attributable to high levels of BMI, ranging by sex from 4-9% in Saudi Arabia and from 0.2-1.2% in India. Overweight and obesity may also influence cancer outcomes, and hence have a varying impact on cancer survival and death in different world regions. Future challenges in cancer studies exploring the association with overweight and obesity concern the measurement of adiposity and its potentially cumulative effect over the life course. Given the limitations of BMI as an imperfect measure of body fatness, routine anthropometric data collection needs to be extended to develop more informative measures, such as waist circumference in settings where the gold standard tools remain unaffordable. Furthermore, questions surrounding the dose-response and timing of obesity and their associations with cancer remain to be answered. Improved surveillance of health risk factors including obesity as well as the scale and profile of cancer in every country of the world is urgently needed. This will enable the design of cost-effective actions to curb the growing burden of cancer related to excess body weight.
authors.affiliation: Section of Cancer Surveillance, International Agency for Research on Cancer (IARC), Lyon, France.
authors.forename: Melina
authors.initials: M
authors.lastname: Arnold
authors.affiliation: Department of Epidemiology and Preventive Medicine, University of Regensburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Leitzmann
authors.affiliation: Section of Nutrition and Metabolism, Dietary Exposure Assessment Group, International Agency for Research on Cancer (IARC), Lyon, France.
authors.forename: Heinz
authors.initials: H
authors.lastname: Freisling
authors.affiliation: Section of Cancer Surveillance, International Agency for Research on Cancer (IARC), Lyon, France.
authors.forename: Freddie
authors.initials: F
authors.lastname: Bray
authors.affiliation: Section of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Romieu
authors.affiliation: Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Renehan
authors.affiliation: Section of Cancer Surveillance, International Agency for Research on Cancer (IARC), Lyon, France. Electronic address: arnoldm@fellows.iarc.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Soerjomataram
mesh_terms: D000273:Adipose Tissue; D000886:Anthropometry; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000453:epidemiology*; D009765:Obesity / Q000453:epidemiology*; D050177:Overweight / Q000453:epidemiology*; D012307:Risk Factors; D055105:Waist Circumference
keywords: Body mass index; Cancer; Global; Obesity; Overweight