title: Effects of Continuous Positive Airway Pressure on Lipidaemia and High-sensitivity C-reactive Protein Levels in Non-obese Patients with Coronary Artery Disease and Obstructive Sleep Apnoea.
abstract: BACKGROUND
  The effect of obesity and medication on the relationship between obstructive sleep apnoea (OSA) and lipidaemia and systemic inflammation is not fully understood for various reasons. The aim of the present study is to determine the effects of 12 months of therapy with continuous positive airway pressure (CPAP) on lipid profiles and high-sensitivity C-reactive protein (hs-CRP) in non-obese patients with coronary artery disease (CAD) and OSA.
  
  
  METHODS
  We consecutively recruited 78 non-obese subjects with newly diagnosed CAD and moderate-to-severe OSA who were taking lipid-lowering medication. Patients were randomised to CPAP treatment or the control group. The patients' lipids and the hs-CRP level were measured at baseline and at follow-up.
  
  
  RESULTS
  Seventy patients completed the study. The CPAP and control groups had similar characteristics at baseline. The mean duration of CPAP treatment was 4.2±1.1h/night. There was no significant difference in the lipids or hs-CRP levels at 12 months (both, P>0.05). The apnoea-hypopnoea index and Epworth Sleepiness Scale were significantly lower in the CPAP treatment group than in the control group (both, P<0.05).
  
  
  CONCLUSIONS
  Continuous positive airway pressure treatment in non-obese patients with CAD and OSA who are taking standardised lipid-lowering treatment does not significantly decrease the lipid or hs-CRP levels. In addition, there are no relationships found between the severity of OSA and the lipid profiles. However, the status of OSA and daytime sleepiness improved significantly in the CPAP group.
  
  
  BACKGROUND
  URL: http://clinicaltrials.gov. Unique identifier: NCT02127177.
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: zhihongliufuwai@163.com.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tang
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D045422:Continuous Positive Airway Pressure; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy
chemical_list: D008055:Lipids; D002097:C-Reactive Protein
keywords: Continuous positive airway pressure; Coronary artery disease; High-sensitivity C-reactive protein; Lipids; Obstructive sleep apnoea