title: [Breast-specific gamma imaging in breast cancer].
abstract: Breast-specific gamma imaging (BSGI) is a new technique in nuclear medicine for the diagnosis of breast cancer. After intravenous injection of the radioactive substance 99mTc-sestamibi the breasts are imaged with a gamma camera. The radionuclide assimilates into intracellular mitochondria, which are present in greater numbers in breast cancer cells than in normal cells. This causes a relatively high uptake of the radionuclide in tumours. Along with mammography and ultrasound, MRI is the current gold standard in breast imaging diagnostics. However, MRI is a complex and expensive procedure and has low specificity leading to high false-positive rates. BSGI has equally high sensitivity but is more specific, cheaper and much simpler to interpret. BSGI could replace MRI as a complementary technique to show, exclude or indicate the extent of breast cancer.
authors.affiliation: Alrijne Ziekenhuis, locatie Leiderdorp.
authors.forename: Ariane A
authors.initials: AA
authors.lastname: van Loevezijn
authors.forename: Adriaan C
authors.initials: AC
authors.lastname: van Breda Vriesman
authors.forename: Peter A
authors.initials: PA
authors.lastname: Neijenhuis
authors.forename: Lenka M
authors.initials: LM
authors.lastname: Pereira Arias-Bouda
mesh_terms: D001940:Breast / Q000000981:diagnostic imaging / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D015902:Gamma Cameras / Q000592:standards*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008327:Mammography; D009928:Organ Specificity; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
chemical_list: D017256:Technetium Tc 99m Sestamibi