title: Estimation of radiation risk in presence of classical additive and Berkson multiplicative errors in exposure doses.
abstract: In this paper, the influence of measurement errors in exposure doses in a regression model with binary response is studied. Recently, it has been recognized that uncertainty in exposure dose is characterized by errors of two types: classical additive errors and Berkson multiplicative errors. The combination of classical additive and Berkson multiplicative errors has not been considered in the literature previously. In a simulation study based on data from radio-epidemiological research of thyroid cancer in Ukraine caused by the Chornobyl accident, it is shown that ignoring measurement errors in doses leads to overestimation of background prevalence and underestimation of excess relative risk. In the work, several methods to reduce these biases are proposed. They are new regression calibration, an additive version of efficient SIMEX, and novel corrected score methods.
authors.affiliation: State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine", Melnykova str., 53, Kyiv, 04050, Ukraine; Ukrainian Radiation Protection Institute, Melnykova str., 53, Kyiv, 04050, Ukraine masja1979@gmail.com.
authors.forename: S V
authors.initials: SV
authors.lastname: Masiuk
authors.affiliation: Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64, Kyiv 01601, Ukraine.
authors.forename: S V
authors.initials: SV
authors.lastname: Shklyar
authors.affiliation: Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64, Kyiv 01601, Ukraine.
authors.forename: A G
authors.initials: AG
authors.lastname: Kukush
authors.affiliation: Texas A&M University, College Station, TX 77843, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Carroll
authors.affiliation: State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine", Melnykova str., 53, Kyiv, 04050, Ukraine; Ukrainian Radiation Protection Institute, Melnykova str., 53, Kyiv, 04050, Ukraine.
authors.forename: L N
authors.initials: LN
authors.lastname: Kovgan
authors.affiliation: State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine", Melnykova str., 53, Kyiv, 04050, Ukraine; Ukrainian Radiation Protection Institute, Melnykova str., 53, Kyiv, 04050, Ukraine.
authors.forename: I A
authors.initials: IA
authors.lastname: Likhtarov
mesh_terms: D047852:Chernobyl Nuclear Accident; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008962:Models, Theoretical; D000069079:Radiation Exposure / Q000706:statistics & numerical data*; D018570:Risk Assessment / Q000379:methods*
keywords: Berkson measurement error; Chornobyl; Classical measurement error; Corrected scores; Dose-response; Radiation epidemiology; Regression calibration; SIMEX