title: The Functional and Molecular Properties, Physiological Functions, and Pathophysiological Roles of GluN2A in the Central Nervous System.
abstract: The NMDA receptor, which is heavily involved in several human brain diseases, is a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins through the C-termini of different subunits. GluN2A and GluN2B are the two primary types of GluN2 subunits in the forebrain. During the developmental period, there is a switch from GluN2B- to GluN2A-containing NMDA receptors in synapses. In the adult brain, GluN2A exists at synaptic sites more abundantly than GluN2B. GluN2A plays important roles not only in synaptic plasticity but also in mediating physiological functions, such as learning and memory. GluN2A has also been involved in many common human diseases, such as cerebral ischemia, seizure disorder, Alzheimer's disease, and systemic lupus erythematosus. The following review investigates the functional and molecular properties, physiological functions, and pathophysiological roles of the GluN2A subunit.
authors.affiliation: Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, Hebei, 050018, China.|Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: North China Pharmaceutical Group New Drug Research and Development Co., Ltd, Shijiazhuang, 050015, China.
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Department of Pathophysiology, Hebei Medical University, Shijiazhuang, 050017, China.
authors.forename: Linan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Nursing, Hebei Medical University, Shijiazhuang, 050017, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, Hebei, 050018, China.
authors.forename: You
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, Hebei, 050018, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Zhan
authors.affiliation: Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, Hebei, 050018, China. yjs0622@163.com.|Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China. yjs0622@163.com.|State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, 050018, China. yjs0622@163.com.
authors.forename: Zibin
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002490:Central Nervous System / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate
keywords: GluN2A; Pathophysiological roles; Physiological functions; Properties