title: Preeclampsia and Vascular Function: A Window to Future Cardiovascular Disease Risk.
abstract: Preeclampsia affects ∼3%-7% of all pregnancies and is the third leading cause of maternal mortality globally. Growing evidence indicates that preeclampsia results from vascular dysfunction, which also increases the risk for future cardiovascular events. Until recently, preeclampsia was considered a disorder limited to pregnancy, which fully resolved with the delivery of the placenta; however, it is now clear that women with a history of preeclampsia have approximately double the risk of future cardiovascular events compared to women with normotensive pregnancies. The aims of this review were to describe the hemodynamic and vascular changes that occur in normal and preeclamptic pregnancies, to review noninvasive methods to test vascular function, and to discuss the associated increased cardiovascular disease risk related to preeclampsia.
authors.affiliation: 1 National Center for Maternal and Child Health , Ulaanbaatar, Mongolia .
authors.forename: Davaasambuu
authors.initials: D
authors.lastname: Enkhmaa
authors.affiliation: 2 Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute , Los Angeles, California.
authors.forename: Danielle
authors.initials: D
authors.lastname: Wall
authors.affiliation: 2 Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute , Los Angeles, California.
authors.forename: Puja K
authors.initials: PK
authors.lastname: Mehta
authors.affiliation: 3 Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital , Harvard Medical School, Boston, Massachusetts.|4 Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, Massachusetts.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Stuart
authors.affiliation: 3 Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital , Harvard Medical School, Boston, Massachusetts.|4 Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, Massachusetts.
authors.forename: Janet Wilson
authors.initials: JW
authors.lastname: Rich-Edwards
authors.affiliation: 2 Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute , Los Angeles, California.
authors.forename: C Noel Bairey
authors.initials: CN
authors.lastname: Merz
authors.affiliation: 2 Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute , Los Angeles, California.
authors.forename: Chrisandra
authors.initials: C
authors.lastname: Shufelt
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis; D008365:Manometry; D010920:Placenta / Q000503:physiopathology*; D011225:Pre-Eclampsia; D011247:Pregnancy; D012307:Risk Factors; D012720:Severity of Illness Index