title: Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder.
abstract: BACKGROUND
  While extensive literature on the role of the serotonin receptor 1A (5-HT1A-R) in cognition exists, the findings are largely from animal studies. There has been little research conducted into 5-HT1A-R genotypes and cognitive function in humans. This article evaluates the role of 5-HT1A-R genotypes on the profile of cognitive function in patients with major depressive disorder (MDD).
  
  
  METHODS
  The study sample was 455 MDD patients aged between 18 and 55 years. They had enrolled into a clinical trial and were tested prior to dosing on the baseline study day using the CDR System, an integrated set of 3 attention tests, 2 working memory tests, and 4 episodic memory tests. 5-HT1A-R genotyping for (SNP ID rs6295) had been conducted during the study screening period.
  
  
  RESULTS
  Validated factor scores were derived from the 9 tests. It was found that patients with the C/C genotype for the C(1019)G polymorphism of the 5-HT1A-R were significantly superior in retaining and retrieving information, in both working and episodic memory, than those with either the C/G or the G/G genotypes. No differences were found in measures of attention or in the speed of retrieval of information from memory.
  
  
  CONCLUSIONS
  This is, to our knowledge, the first relationship found between objective tests of cognitive function and 5-HT1A-R genotypes in MDD.
authors.affiliation: 1Wesnes Cognition Ltd.,Streatley on Thames,UK.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Wesnes
authors.affiliation: 4Global Translational Medicine & Early Development,Sunovion Pharmaceuticals Inc.,Marlborough,Massachusetts,USA.
authors.forename: Seth C
authors.initials: SC
authors.lastname: Hopkins
authors.affiliation: 1Wesnes Cognition Ltd.,Streatley on Thames,UK.
authors.forename: Helen J
authors.initials: HJ
authors.lastname: Brooker
authors.affiliation: 4Global Translational Medicine & Early Development,Sunovion Pharmaceuticals Inc.,Marlborough,Massachusetts,USA.
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Koblan
mesh_terms: D000293:Adolescent; D000328:Adult; D003071:Cognition; D003865:Major Depressive Disorder / Q000235:genetics / Q000523:psychology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008568:Memory; D061212:Memory, Episodic; D008570:Memory, Short-Term; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D055815:Young Adult
chemical_list: D044282:Receptor, Serotonin, 5-HT1A
keywords: 5-HT1A-R; CDR System; MDD; cognitive function; genotypes; memory