title: An Ugi Reaction Incorporating a Redox-Neutral Amine C-H Functionalization Step.
abstract: Pyrrolidine and 1,2,3,4-tetrahydroisoquinoline (THIQ) undergo redox-neutral α-amidation with concurrent N-alkylation upon reaction with aromatic aldehydes and isocyanides. Reactions are promoted by acetic acid and represent a new variant of the Ugi reaction.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.
authors.forename: Zhengbo
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.
authors.forename: Daniel
authors.initials: D
authors.lastname: Seidel
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011759:Pyrrolidines / Q000737:chemistry*; D044005:Tetrahydroisoquinolines / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000588:Amines; D003486:Cyanides; D011759:Pyrrolidines; D044005:Tetrahydroisoquinolines; D019342:Acetic Acid