title: Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats.
abstract: Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients. Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications. The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats. Diabetic wound model was prepared by making an incision with full thickness in STZ-induced diabetic rats. Wounds from diabetic rats were treated with 10% hemin ointment for 21 days. Increase of HO-1 protein expression enhanced anti-inflammation and antioxidant in diabetic rats. Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein. In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats.
authors.affiliation: Medical Department, General Hospital of Jinan Military Command, 25 Shifan Road, Jinan, Shandong 250031, China.
authors.forename: Qing-Ying
authors.initials: QY
authors.lastname: Chen
authors.affiliation: Department of Pathophysiology, Wannan Medical College, Wuhu 241002, China.
authors.forename: Guo-Guang
authors.initials: GG
authors.lastname: Wang
authors.affiliation: Department of Pathophysiology, Wannan Medical College, Wuhu 241002, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Physiology, Wannan Medical College, Wuhu 241002, China.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Jiang
authors.affiliation: Department of Pathophysiology, Wannan Medical College, Wuhu 241002, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Lu
authors.affiliation: Department of Physiology, Wannan Medical College, Wuhu 241002, China.
authors.forename: Ping-Ping
authors.initials: PP
authors.lastname: Zhou
mesh_terms: D000279:Administration, Cutaneous; D043925:Angiogenesis Inducing Agents / Q000008:administration & dosage; D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000975:Antioxidants / Q000008:administration & dosage; D016207:Cytokines / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000201:enzymology* / Q000473:pathology; D004790:Enzyme Induction; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis*; D006427:Hemin / Q000008:administration & dosage; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009824:Ointments; D018384:Oxidative Stress / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000098:blood supply / Q000187:drug effects / Q000201:enzymology* / Q000293:injuries / Q000473:pathology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects; D014950:Wounds, Penetrating / Q000150:complications / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology
chemical_list: D043925:Angiogenesis Inducing Agents; D042501:Angiogenic Proteins; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016207:Cytokines; D018836:Inflammation Mediators; D009824:Ointments; D006427:Hemin; D006419:Heme Oxygenase (Decyclizing); C491523:Hmox1 protein, rat