title: Experimental reproduction of beak atrophy and dwarfism syndrome by infection in cherry valley ducklings with a novel goose parvovirus-related parvovirus.
abstract: Infection of clinically susceptible ducks, including cherry valley and Muscovy ducks, with a novel goose parvovirus (GPV)-related virus (N-GPV) can result in beak atrophy and dwarfism syndrome (BADS). To obtain new insights into the host range and pathogenic potential of this novel waterfowl parvovirus, cherry valley ducklings (n=20) were experimentally infected with N-GPV strain SDLC01. An equal number of ducklings served as uninfected controls. The appearance of clinical signs, histopathological changes, viral shedding, and seroconversion was monitored for 20 days post-infection. Infection status of all ducks was monitored using indirect ELISA, virus neutralization test, nested PCR, clinical indicators, and microscopic examination. Three ducks developed the typical clinical, gross, and histological changes of BADS. By study day 6, the infected ducks had seroconverted to N-GPV. The antibodies raised were neutralizing against the SDLC01 strain in vitro. Here we successfully developed an experimental infection model for studying the pathogenicity and role of N-GPV in BADS.
authors.affiliation: College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271018,China.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.affiliation: College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271018,China.
authors.forename: Yanguo
authors.initials: Y
authors.lastname: Dou
authors.affiliation: College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271018,China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tang
authors.affiliation: College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271018,China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Zheng
authors.affiliation: College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271018,China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Niu
authors.affiliation: College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271018,China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271018,China.
authors.forename: Xianglong
authors.initials: X
authors.lastname: Yu
authors.affiliation: College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271018,China. Electronic address: yxdiao@126.com.
authors.forename: Youxiang
authors.initials: Y
authors.lastname: Diao
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001502:Beak / Q000473:pathology; D002681:China; D004372:Ducks; D004797:Enzyme-Linked Immunosorbent Assay; D005777:Geese; D009500:Neutralization Tests; D010322:Parvoviridae Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D017992:Parvovirus / Q000302:isolation & purification / Q000502:physiology; D016133:Polymerase Chain Reaction; D011201:Poultry Diseases / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D011897:Random Allocation; D000069078:Seroconversion; D017201:Virus Shedding
chemical_list: D000914:Antibodies, Viral
keywords: Beak atrophy and dwarfism syndrome; Cherry valley duck; Experimental infection; Novel GPV-related parvovirus