title: Orthostatic stress causes immediately increased blood pressure variability in women with vasovagal syncope.
abstract: The cardiovascular and respiratory autonomic nervous regulation has been studied mainly by hemodynamic responses during different physical stressors. In this study, dynamics of autonomic response to an orthostatic challenge was investigated by hemodynamic variables and by diverse linear and nonlinear indices calculated from time series of beat-to-beat intervals (BBI), respiratory cycle duration (RESP), systolic (SYS) and diastolic (DIA) blood pressure. This study included 16 young female patients (SYN) with vasovagal syncope and 12 age-matched female controls (CON). The subjects were enrolled in a head-up tilt (HUT) test, breathing normally, including 5min of baseline (BL, supine position) and 18min of 70° orthostatic phase (OP). To increase the time resolution of the analysis the time series were segmented in five-minute overlapping windows with a shift of 1min. Hemodynamic parameters did not show any statistical differences between SYN and CON. Time domain linear analysis revealed increased respiratory frequency and increased blood pressure variability (BPV) in patients during OP meaning increased sympathetic activity and vagal withdrawal. Frequency domain analysis confirmed a predominance of sympathetic tone by steadily increased values of low over high frequency power in BBI and of low frequency power in SYS and DIA in patients during OP. The nonlinear analysis by symbolic dynamics seemed to be highly suitable for differentiation of SYN and CON in the early beginning of OP, i.e., 5min after tilt-up. In particular the index SYS_plvar3 showed less patterns of low variability in patients reflecting a steadily increase in both BPV and sympathetic activity. The proposed dynamical analysis could lead to a better understanding of the temporal underlying mechanisms in healthy subjects and patients under orthostatic stress.
authors.affiliation: Universidad Autónoma Metropolitana, Electrical Engineering Department, Mexico City, Mexico.
authors.forename: S
authors.initials: S
authors.lastname: Reulecke
authors.affiliation: Universidad Autónoma Metropolitana, Electrical Engineering Department, Mexico City, Mexico. Electronic address: schv@xanum.uam.mx.
authors.forename: S
authors.initials: S
authors.lastname: Charleston-Villalobos
authors.affiliation: University of Applied Sciences Jena, Department of Medical Engineering and Biotechnology, Jena, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Voss
authors.affiliation: Universidad Autónoma Metropolitana, Health Science Department, Mexico City, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: González-Camarena
authors.affiliation: National Institute of Cardiology, Mexico City, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: González-Hermosillo
authors.affiliation: Universidad Autónoma Metropolitana, Health Science Department, Mexico City, Mexico.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gaitán-González
authors.affiliation: National Institute of Cardiology, Mexico City, Mexico.
authors.forename: G
authors.initials: G
authors.lastname: Hernández-Pacheco
authors.affiliation: University of Applied Sciences Jena, Department of Medical Engineering and Biotechnology, Jena, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Schroeder
authors.affiliation: Universidad Autónoma Metropolitana, Electrical Engineering Department, Mexico City, Mexico.
authors.forename: T
authors.initials: T
authors.lastname: Aljama-Corrales
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D011187:Posture; D019462:Syncope, Vasovagal / Q000209:etiology*; D055815:Young Adult
keywords: Autonomic regulation; Blood pressure variability; Heart rate variability; Nonlinear dynamics; Orthostatic stress; Respiratory cycle