title: Expression and significance of Ku80 and PDGFR-α in nasal NK/T-cell lymphoma.
abstract: BACKGROUND
  To investigate the clinical and prognostic significance of Ku80 and PDGFR-α in nasal type NK/T cell lymphoma (NKTCL).
  
  
  METHODS
  Immunohistochemistry for Ku80 and PDGFR-α was performed on tissue sections from 35 patients diagnosed with NKTCL. We analyzed the relationship between Ku80 and PDGFR-α expression and the clinicopathological features of NKTCL. We further performed multivariate analyses to identify prognostic factors for progression free survival (PFS) of patients.
  
  
  RESULTS
  Ku80 expression rate in NKTCL was 94.3% compared with that in reactive lymphoid hyperplasia of nasopharynx (P=0.003). The positive expression rate of PDGFR-α in the group of NKTCL was 91.4% compared with that in control group (P=0.004). The positive correlation between Ku80 and PDGFR-α was also found (r=0.496, P=0.002). Ku80 and PDGFR-α expressions were not correlated with patient's gender, age, B symptoms, LDH, Ann Arbor stage, IPI score and treatment (P>0.05). High expression of Ku80 and PDGFR-α was shown to be correlated with worse PFS (P=0.003 and 0.034, respectively). Multivariate analysis with a Cox proportional hazards model further suggested that Ku80 high expression rate (HR, 11.495; P=0.009), PDGFR-α high expression rate (HR, 4.836; P=0.031) and International Prognostic Index (IPI) score of 3-4 (HR, 7.308; P=0.001) were statistically independent prognostic factors for patients' PFS. Our results suggest that Ku80 and PDGFR-α may be valuable indicators for predicting the survival of NKTCL patients.
  
  
  CONCLUSIONS
  Ku80 and PDGFR-α might be effective predictive indicators for the prognosis of NKTCL. A large prospective study is required to confirm the prognostic significance of Ku80 and PDGFR-α in NKTCL.
authors.affiliation: Department of Thyroid Tumour Internal Medicine, Hunan Cancer Hospital of Xiangya School of Medicine, Central South University, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Pharmacology, Hunan Institute for Food and Drug Control, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Oncology, Xiangya Hospital of Xiangya School of Medicine, Central South University, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Integrated Chinese and Western Medicine, Xiangya Hospital of Xiangya School of Medicine, Central South University, PR China.
authors.forename: Zian
authors.initials: Z
authors.lastname: Xia
authors.affiliation: Department of Thyroid Tumour Internal Medicine, Hunan Cancer Hospital of Xiangya School of Medicine, Central South University, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.affiliation: Department of Oncology, Xiangya Hospital of Xiangya School of Medicine, Central South University, PR China. Electronic address: 13787096792@163.com.
authors.forename: Meizuo
authors.initials: M
authors.lastname: Zhong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D000072200:Ku Autoantigen / Q000032:analysis / Q000096:biosynthesis*; D054391:Lymphoma, Extranodal NK-T-Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000032:analysis / Q000096:biosynthesis*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D020796:Receptor, Platelet-Derived Growth Factor alpha; D000072200:Ku Autoantigen
keywords: Immunohistochemistry; Ku80; Nasal NK/T cell lymphoma; PDGFR-α