title: Music exposure improves spatial cognition by enhancing the BDNF level of dorsal hippocampal subregions in the developing rats.
abstract: Previous research has shown that dorsal hippocampus plays an important role in spatial memory process. Music exposure can enhance brain-derived neurotrophic factor (BDNF) expression level in dorsal hippocampus (DH) and thus enhance spatial cognition ability. But whether music experience may affect different subregions of DH in the same degree remains unclear. Here, we studied the effects of exposure to Mozart K.448 on learning behavior in developing rats using the classical Morris water maze task. The results showed that early music exposure could enhance significantly learning performance of the rats in the water maze test. Meanwhile, the BDNF/TrkB level of dorsal hippocampus CA3 (dCA3) and dentate gyrus (dDG) was significantly enhanced in rats exposed to Mozart music as compared to those without music exposure. In contrast, the BDNF/TrkB level of dorsal hippocampus CA1 (dCA1) was not affected. The results suggest that the spatial memory improvement by music exposure in rats may be associated with the enhanced BDNF/TrkB level of dCA3 and dDG.
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China; School of Electronic Information Engineering of Yangtze Normal University, Chongqing FuLing, 408100, China.
authors.forename: Yingshou
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Wenxi
authors.initials: W
authors.lastname: Chen
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Yanran
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jing
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Daqing
authors.initials: D
authors.lastname: Guo
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China. Electronic address: xiayang@uestc.edu.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
mesh_terms: D000161:Acoustic Stimulation; D000367:Age Factors; D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D003071:Cognition / Q000502:physiology*; D005260:Female; D020712:Fornix, Brain / Q000254:growth & development* / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D008297:Male; D018782:Maze Learning; D009146:Music; D051381:Rats; D017207:Rats, Sprague-Dawley; D020813:Receptor, trkB / Q000378:metabolism; D065853:Spatial Learning / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D020813:Receptor, trkB
keywords: BDNF/TrkB; Cognitive ability; Hippocampal subregion; Mozart music