title: Risk factors for nosocomial tuberculosis transmission among health care workers.
abstract: We conducted hospital-based contact investigations of 55 serial sputum smear-positive tuberculosis (TB) patients and 771 health care workers (HCWs) from 2006-2013. HCWs who made contact with TB patients in the absence of appropriate airborne precautions were evaluated using interferon gamma release assays to identify TB infection. Twenty-nine HCWs (3.8%) were newly diagnosed with TB infection. The 10 TB patients responsible for transmission had a duration of contact of >7 days by multivariate analysis.
authors.affiliation: Department of Respiratory Medicine, Kyoto University, Kyoto, Japan; Infection Control and Prevention, Kyoto University, Kyoto, Japan; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University School of Medical Science, Nagoya, Japan. Electronic address: yutaka@med.nagoya-cu.ac.jp.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ito
authors.affiliation: Infection Control and Prevention, Kyoto University, Kyoto, Japan; Clinical Laboratory of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Nagao
authors.affiliation: Department of Infectious Diseases, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Iinuma
authors.affiliation: Infection Control and Prevention, Kyoto University, Kyoto, Japan; Clinical Laboratory of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Matsumura
authors.affiliation: Infection Control and Prevention, Kyoto University, Kyoto, Japan; Clinical Laboratory of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Infection Control and Prevention, Kyoto University, Kyoto, Japan; Clinical Laboratory of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Takakura
authors.affiliation: Infection Control and Prevention, Kyoto University, Kyoto, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Igawa
authors.affiliation: Infection Control and Prevention, Kyoto University, Kyoto, Japan.
authors.forename: Hiroe
authors.initials: H
authors.lastname: Yamanaka
authors.affiliation: Infection Control and Prevention, Kyoto University, Kyoto, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Hashimoto
authors.affiliation: Department of Respiratory Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Toyohiro
authors.initials: T
authors.lastname: Hirai
authors.affiliation: Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University School of Medical Science, Nagoya, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Niimi
authors.affiliation: Infection Control and Prevention, Kyoto University, Kyoto, Japan; Clinical Laboratory of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ichiyama
authors.affiliation: Department of Respiratory Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003428:Cross Infection / Q000635:transmission*; D018562:Disease Transmission, Infectious; D005260:Female; D006282:Health Personnel; D006801:Humans; D059425:Interferon-gamma Release Tests; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014376:Tuberculosis / Q000635:transmission*
keywords: Tuberculosis; health care workers; hospital transmission; interferon gamma release assay; risk factor