title: What Makes MAITs Wait?
abstract: Mucosal-associated invariant T (MAIT) cells recognize microbial non-peptidic antigens presented by non-classical MHC MR1. In this issue of Immunity, Gherardin et al. (2016) show co-crystal structures of MR1 complexed to T cell receptors (TCRs) from two classes of MAIT-type cells.
authors.affiliation: Manchester Collaborative Center for Inflammation Research, University of Manchester, Manchester M13 9NT, UK; Gastroenterology, Brigham & Women's Hospital, Harvard Medical School, Boston 02115, MA, USA; Agenus, Inc., Lexington, MA 02421, USA. Electronic address: mexley@partners.org.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Exley
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D015778:Minor Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015395:Histocompatibility Antigens Class I; C094840:MR1 protein, human; D015778:Minor Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell