title: Photophysical and photochemical studies of a novel amphiphilic zinc phthalocyanine and its interaction with calf thymus DNA.
abstract: β-tetra (aminophenoxy) sulfonic substituted zinc phthalocyanines (SNZnPc), a novel amphiphilic zinc phthalocyanine (Pc), was synthesized. The photophysical, photochemical, and photobiology properties were studied. Results indicated that the synthesized SNZnPc has good amphiphilic property and high reactive oxygen species (ROSs) generation ability. Furthermore, SNZnPc has strong affinity to calf thymus DNA (CT-DNA) through intercalation ways and can effectively cleavage CT-DNA after irradiation by light with appropriate wavelength.
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu, Key Laboratory of Biomedical Materials, School of Chemistry and Materials Science, Analysis and Testing Center, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Linxin
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu, Key Laboratory of Biomedical Materials, School of Chemistry and Materials Science, Analysis and Testing Center, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Li
authors.initials: L
authors.lastname: Gui
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu, Key Laboratory of Biomedical Materials, School of Chemistry and Materials Science, Analysis and Testing Center, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu, Key Laboratory of Biomedical Materials, School of Chemistry and Materials Science, Analysis and Testing Center, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Quanquan
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu, Key Laboratory of Biomedical Materials, School of Chemistry and Materials Science, Analysis and Testing Center, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu, Key Laboratory of Biomedical Materials, School of Chemistry and Materials Science, Analysis and Testing Center, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, China. Electronic address: shwei@njnu.edu.cn.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wei
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D004996:Ethidium / Q000378:metabolism; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D054833:Isoindoles; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D055668:Photochemical Processes; D026082:Singlet Oxygen / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013501:Surface-Active Agents / Q000378:metabolism*; D044366:Transition Temperature; D017967:Zinc Compounds
chemical_list: D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D013501:Surface-Active Agents; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D026082:Singlet Oxygen; D004247:DNA; C427203:calf thymus DNA; D004996:Ethidium
keywords: Amphiphilic; CT-DNA; Photodynamic activity; Reactive oxygen species; Zinc phthalocyanine