title: Primary Small Cell Carcinoma of the Esophagus (PSCEC) Associated with Paraneoplastic Sweating Syndrome: A Case Report and Literature Review.
abstract: BACKGROUND
  Primary small cell carcinoma of the esophagus (PSCEC) associated with paraneoplastic sweating syndrome is a rare disease characterized with rapid growth rate, metastasis at the time of diagnosis, and poor prognosis. The lung is the most common site for small cell carcinoma but this malignancy includes 0.1% to 1% of all gastrointestinal and 0.8% to 2.7% of esophageal malignancies. So far more than 200 cases of PSCEC have been reported in literature.
  
  
  METHODS
  The patient is a 54-year-old female from the Golestan province who presented with dysphagia, 19 kg-weight loss (from 105 kgs to 86 kgs), and excessive sweating. She was admitted in the thoracic surgery ward, at Ghaem Hospital, in the Mashhad University of Medical Sciences, with a pathological diagnosis of small cell carcinoma. She underwent transhiatal total esophagectomy. Excessive sweating was eradicated after surgery and she was discharged after 13 days without any complication. She received chemotherapy and at her 5-year follow up, she showed no recurrence or metastasis.
  
  
  CONCLUSIONS
  PSCEC usually requires chemotherapy with or without surgery. A favorable outcome, with total resection of the lesion combined with chemotherapy, was obtained. However, due to the rarity of the disease there is no definitive choice of treatment.
authors.affiliation: Department of Thoracic Surgery, Mashad University of Medical Sciences, Iran.
authors.forename: Seyed Hosein
authors.initials: SH
authors.lastname: Fattahi Masoum
authors.affiliation: Solid Tumor Treatment Research Center, Faculty of Medicine, Mashad University of Medical Sciences, Iran.
authors.forename: Noorieh
authors.initials: N
authors.lastname: Sharifi
authors.affiliation: Solid Tumor Treatment Research Center, Faculty of Medicine, Mashad University of Medical Sciences, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Taraz Jamshidi
authors.affiliation: Department of Anesthesiology, Mashad University of Medical Sciences, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Sharifian
authors.affiliation: Department of Thoracic Surgery, Mashad University of Medical Sciences, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Rezaee
keywords: Chemotherapy; Paraneoplastic syndrome; Prognosis; Small cell carcinoma