title: Increasing Prevalence of Gastroschisis--14 States, 1995-2012.
abstract: Gastroschisis is a serious congenital defect in which the intestines protrude through an opening in the abdominal wall. Gastroschisis requires surgical repair soon after birth and is associated with an increased risk for medical complications and mortality during infancy. Reports from multiple surveillance systems worldwide have documented increasing prevalence of gastroschisis since the 1980s, particularly among younger mothers; however, since publication of a multistate U.S. report that included data through 2005, it is not known whether prevalence has continued to increase. Data on gastroschisis from 14 population-based state surveillance programs were pooled and analyzed to assess the average annual percent change (AAPC) in prevalence and to compare the prevalence during 2006-2012 with that during 1995-2005, stratified by maternal age and race/ethnicity. The pooled data included approximately 29% of U.S. births for the period 1995-2012. During 1995-2012, gastroschisis prevalence increased in every category of maternal age and race/ethnicity, and the AAPC ranged from 3.1% in non-Hispanic white (white) mothers aged <20 years to 7.9% in non-Hispanic black (black) mothers aged <20 years. These corresponded to overall percentage increases during 1995-2012 that ranged from 68% in white mothers aged <20 years to 263% in black mothers aged <20 years. Gastroschisis prevalence increased 30% between the two periods, from 3.6 per 10,000 births during 1995-2005 to 4.9 per 10,000 births during 2006-2012 (prevalence ratio = 1.3, 95% confidence interval [CI]: 1.3-1.4), with the largest increase among black mothers aged <20 years (prevalence ratio = 2.0, 95% CI: 1.6-2.5). Public health research is urgently needed to identify factors contributing to this increase.
authors.forename: Abbey M
authors.initials: AM
authors.lastname: Jones
authors.forename: Jennifer
authors.initials: J
authors.lastname: Isenburg
authors.forename: Jason L
authors.initials: JL
authors.lastname: Salemi
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Arnold
authors.forename: Cara T
authors.initials: CT
authors.lastname: Mai
authors.forename: Deepa
authors.initials: D
authors.lastname: Aggarwal
authors.forename: William
authors.initials: W
authors.lastname: Arias
authors.forename: Gerard E
authors.initials: GE
authors.lastname: Carrino
authors.forename: Emily
authors.initials: E
authors.lastname: Ferrell
authors.forename: Olakunle
authors.initials: O
authors.lastname: Folorunso
authors.forename: Brendan
authors.initials: B
authors.lastname: Ibe
authors.forename: Russell S
authors.initials: RS
authors.lastname: Kirby
authors.forename: Heidi R
authors.initials: HR
authors.lastname: Krapfl
authors.forename: Lisa K
authors.initials: LK
authors.lastname: Marengo
authors.forename: Bridget S
authors.initials: BS
authors.lastname: Mosley
authors.forename: Amy E
authors.initials: AE
authors.lastname: Nance
authors.forename: Paul A
authors.initials: PA
authors.lastname: Romitti
authors.forename: Joseph
authors.initials: J
authors.lastname: Spadafino
authors.forename: Jennifer
authors.initials: J
authors.lastname: Stock
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Honein
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D017677:Age Distribution; D005260:Female; D020139:Gastroschisis / Q000453:epidemiology* / Q000208:ethnology; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D007231:Infant, Newborn; D011159:Population Surveillance; D011247:Pregnancy; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult