title: Self-Reported Sleep Duration in Patients with Neovascular Age-Related Macular Degeneration.
abstract: OBJECTIVE
  To examine the relationship between self-reported sleep duration and neovascular age-related macular degeneration (nAMD).
  
  
  METHODS
  This case-control study comprised 165 subjects (57 patients with nAMD and 108 controls). Controls were matched to cases by age and sex. Participants completed a questionnaire that included questions about sleep duration and quality. Four categories of sleep duration were established; <6 hours, 6-7 hours, 7-8 hours and >8 hours. Association of sleep duration and nAMD was assessed by logistic regression analysis. Multiple logistic regression models were performed to control for possible confounders.
  
  
  RESULTS
  We found a significant association between short sleep duration and nAMD (for <6 hours, odds ratio, OR, 3.29, 95% confidence interval, CI, 1.32-8.27; for 6-7 hours, OR 2.25, 95% CI 0.80-6.32; and for >8 hours, OR 1.39, 95% CI 0.53-3.73) compared with the reference category of 7-8 hours. This association remained significant after adjustment for confounders (<6 hours, OR 3.09, 95% CI 1.20-7.97). In addition, a borderline significant association was observed between self-reported very bad sleep quality and nAMD (OR 2.84, 95% CI 1.02-7.88). The highest rate of sleep medication use was found in the nAMD group (p < 0.001).
  
  
  CONCLUSIONS
  Our findings provide evidence to support an association between short sleep duration and nAMD. Considering strategies to improve sleep in these patients may prevent the negative effects of sleep deficiency.
authors.affiliation: a Department of Ophthalmology , Alicante University General Hospital , Alicante , Spain.
authors.forename: Jose L
authors.initials: JL
authors.lastname: Pérez-Canales
authors.affiliation: a Department of Ophthalmology , Alicante University General Hospital , Alicante , Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Rico-Sergado
authors.affiliation: a Department of Ophthalmology , Alicante University General Hospital , Alicante , Spain.|b OftalVist Group , Alicante , Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Pérez-Santonja
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D057566:Self Report; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D057135:Wet Macular Degeneration / Q000503:physiopathology*
keywords: Age-related macular degeneration; choroidal neovascularization; self-report; sleep; sleep duration; sleep quality