title: Surgical Stage I high-grade ovarian cancer: is adjuvant chemotherapy warranted?
abstract: OBJECTIVE
  To review the results of patients with high-grade Stage I ovarian cancer managed without adjuvant treatment.
  
  
  METHODS
  A retrospective chart review identified patients with newly diagnosed Stage I high-grade ovarian cancer, who underwent comprehensive surgical staging.
  
  
  RESULTS
  Thirty-three patients with FIGO surgical Stage I high-grade ovarian cancer were identified. After a median follow-up of 40 months, nine patients (27%) recurred. The median time to recurrence was 19 months. Of the nine patients with recurrences, four (44%) are alive with disease, three (33%) patients have no evidence of disease, and two have died of disease (22%). The two- and five-year overall survival is 100% and 90%, respectively.
  
  
  CONCLUSIONS
  It would appear the recurrence rates of Stage I high risk epithelial ovarian cancer completely staged, without adjuvant treatment are comparable to those of treatment arms reported in the literature. A proportion of these patients can be salvaged at recurrence, yielding a high overall survival.
authors.forename: Y
authors.initials: Y
authors.lastname: Segev
authors.forename: N
authors.initials: N
authors.lastname: Ismiil
authors.forename: R
authors.initials: R
authors.lastname: McVey
authors.forename: A
authors.initials: A
authors.lastname: Covens
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D012189:Retrospective Studies