title: A Lifestyle Physical Activity Intervention for Patients with Chronic Obstructive Pulmonary Disease. A Randomized Controlled Trial.
abstract: Physical inactivity is associated with poor outcomes among patients with chronic obstructive pulmonary disease (COPD).
  
  
  
  To determine effectiveness of a behavioral intervention intended to increase daily physical activity with the goal of improving health-related quality of life and functional performance.
  
  
  
  We conducted a randomized trial among patients with COPD cared for in primary care and pulmonary clinics. The patients were at least 45 years of age and eligible for pulmonary rehabilitation. All patients received self-management education during a 6-week run-in period. Subsequently, patients were randomized to usual care or the intervention delivered over 20 weeks.
  
  
  
  Co-primary outcomes were change from baseline in Chronic Respiratory Questionnaire dyspnea domain score and 6-minute-walk distance measured at 6, 12, and 18 months after randomization. A total of 325 patients were enrolled, with 156 randomized to receive usual care and 149 to receive the intervention. At 18 months, there was no overall statistical or clinically significant change in the dyspnea domain in either group. However, for 6-minute-walk distance, there were statistically significant declines in both groups. In contrast, 6-minute-walk distance remained stable (5.3 m; P = 0.54) among patients in the intervention group with moderate spirometric impairment, but it was associated with clinically and statistically significant declines (-28.7 m; P = 0.0001) among usual care patients with moderate spirometric impairment. Overall, there was no increase in adverse events associated with the intervention, which was associated with a lower prevalence of hospitalization for COPD exacerbations (28.3%) compared with usual care (49.5%).
  
  
  
  During this 18-month trial among outpatients with COPD, a health coach-based behavioral intervention did not improve scores in the dyspnea domain of the Chronic Respiratory Questionnaire or 6-minute-walk test distance. However, subgroup analyses suggested that there may be differential effects for specific outcomes that vary with severity of COPD. Specifically, benefits of this low-intensity intervention may be limited to 6-minute walk distance among patients with moderate spirometric impairment. Clinical trial registered with www.clinicaltrials.gov (NCT1108991).
authors.affiliation: 1 Veterans Affairs Portland Health Care System, Portland, Oregon.|2 Oregon Health Science University, Portland, Oregon.
authors.forename: David B
authors.initials: DB
authors.lastname: Coultas
authors.affiliation: 3 Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Bradford E
authors.initials: BE
authors.lastname: Jackson
authors.affiliation: 4 Department of Medicine, University of Texas Health Sciences Center at Tyler, Tyler, Texas.
authors.forename: Rennie
authors.initials: R
authors.lastname: Russo
authors.affiliation: 4 Department of Medicine, University of Texas Health Sciences Center at Tyler, Tyler, Texas.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Peoples
authors.affiliation: 5 Department of Health and Kinesiology, University of Texas at Tyler, Tyler, Texas.
authors.forename: John
authors.initials: J
authors.lastname: Sloan
authors.affiliation: 3 Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Karan P
authors.initials: KP
authors.lastname: Singh
authors.affiliation: 6 Behavioral Health Center, Baylor Medical Center, Plano, Texas; and.
authors.forename: Jamile
authors.initials: J
authors.lastname: Ashmore
authors.affiliation: 7 Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
authors.forename: Steven N
authors.initials: SN
authors.lastname: Blair
authors.affiliation: 3 Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Minyong
authors.initials: M
authors.lastname: Uhm
authors.affiliation: 3 Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Sejong
authors.initials: S
authors.lastname: Bae
mesh_terms: D000368:Aged; D018450:Disease Progression; D015444:Exercise; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008019:Life Style; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000534:rehabilitation*; D011788:Quality of Life; D000073278:Self-Management; D013147:Spirometry; D011795:Surveys and Questionnaires; D014481:United States; D000070857:Walk Test
keywords: chronic obstructive pulmonary disease; physical activity; pulmonary rehabilitation; randomized trial; self-management