title: Continuous Cavitation Designed for Enhancing Radiofrequency Ablation via a Special Radiofrequency Solidoid Vaporization Process.
abstract: Lowering power output and radiation time during radiofrequency (RF) ablation is still a challenge. Although it is documented that metal-based magnetothermal conversion and microbubbles-based inertial cavitation have been tried to overcome above issues, disputed toxicity and poor magnetothermal conversion efficiency for metal-based nanoparticles and violent but transient cavitation for microbubbles are inappropriate for enhancing RF ablation. In this report, a strategy, i.e., continuous cavitation, has been proposed, and solid menthol-encapsulated poly lactide-glycolide acid (PLGA) nanocapsules have been constructed, as a proof of concept, to validate the role of such a continuous cavitation principle in continuously enhancing RF ablation. The synthesized PLGA-based nanocapsules can respond to RF to generate menthol bubbles via distinctive radiofrequency solidoid vaporization (RSV) process, meanwhile significantly enhance ultrasound imaging for HeLa solid tumor, and further facilitate RF ablation via the continuous cavitation, as systematically demonstrated both in vitro and in vivo. Importantly, this RSV strategy can overcome drawbacks and limitations of acoustic droplet vaporization (ADV) and optical droplet vaporization (ODV), and will probably find broad applications in further cancer theranostics.
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine , 301 Yan-chang-zhong Road, Shanghai 200072, P. R. China.|Ultrasound Research and Education Institute, Tongji University School of Medicine , 301 Yan-chang-zhong Road, Shanghai 200072, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine , 301 Yan-chang-zhong Road, Shanghai 200072, P. R. China.
authors.forename: Pei
authors.initials: P
authors.lastname: Li
authors.affiliation: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science , 1295 Ding-Xi Road, Shanghai 200050, P. R. China.
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine , 301 Yan-chang-zhong Road, Shanghai 200072, P. R. China.
authors.forename: Xiaowan
authors.initials: X
authors.lastname: Bo
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine , 301 Yan-chang-zhong Road, Shanghai 200072, P. R. China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine , 301 Yan-chang-zhong Road, Shanghai 200072, P. R. China.|Ultrasound Research and Education Institute, Tongji University School of Medicine , 301 Yan-chang-zhong Road, Shanghai 200072, P. R. China.
authors.forename: Huixiong
authors.initials: H
authors.lastname: Xu
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000818:Animals; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008610:Menthol / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D045423:Microbubbles / Q000627:therapeutic use*; D053769:Nanocapsules / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D061208:Pulsed Radiofrequency Treatment / Q000379:methods*; D013552:Swine
chemical_list: D053769:Nanocapsules; D008610:Menthol; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid
keywords: continuous cavitation; poly lactide-glycolide acid (PLGA) nanocapsules; radiofrequency ablation; radiofrequency solidoid vaporization; triphase transformation