title: Functional Interfaces Constructed by Controlled/Living Radical Polymerization for Analytical Chemistry.
abstract: The high-value applications of functional polymers in analytical science generally require well-defined interfaces, including precisely synthesized molecular architectures and compositions. Controlled/living radical polymerization (CRP) has been developed as a versatile and powerful tool for the preparation of polymers with narrow molecular weight distributions and predetermined molecular weights. Among the CRP system, atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) are well-used to develop new materials for analytical science, such as surface-modified core-shell particles, monoliths, MIP micro- or nanospheres, fluorescent nanoparticles, and multifunctional materials. In this review, we summarize the emerging functional interfaces constructed by RAFT and ATRP for applications in analytical science. Various polymers with precisely controlled architectures including homopolymers, block copolymers, molecular imprinted copolymers, and grafted copolymers were synthesized by CRP methods for molecular separation, retention, or sensing. We expect that the CRP methods will become the most popular technique for preparing functional polymers that can be broadly applied in analytical chemistry.
authors.affiliation: Department of Pharmaceutical Analysis, China Pharmaceutical University , Nanjing, 210009, China.|Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education , Nanjing 210009, China.
authors.forename: Huai-Song
authors.initials: HS
authors.lastname: Wang
authors.affiliation: Department of Pharmaceutical Analysis, China Pharmaceutical University , Nanjing, 210009, China.|Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education , Nanjing 210009, China.
authors.forename: Min
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Pharmaceutical Analysis, China Pharmaceutical University , Nanjing, 210009, China.|Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education , Nanjing 210009, China.
authors.forename: Tai-Jun
authors.initials: TJ
authors.lastname: Hang
keywords: analytical chemistry; controlled/living radical polymerization; fluorescent or colorimetric sensors; molecularly imprinted polymers; separation materials