title: [Estimation of plasma 25(OH)D vitamin level in patients with metabolic syndrome].
abstract: Cardiovascular diseases are a major public health problem in developed and developing countries. A number of recent studies point to the pleiotropic differentiated effects of vitamin D, the deficiency of which positively correlates with the increased risk for cardiovascular diseases, hypertension, dyslipidemia, obesity or metabolic syndrome (MS). Vitamin D deficiency has also been proven to affect the progression of atherosclerosis.
  
  
  OBJECTIVE
  of this study was to evaluate plasma 25(OH)D level in patients with MS.
  
  
  METHODS
  The study included 268 patients with MS, 136 men and 132 women, aged 30-65 years (mean 59,62±9,21 years). The study group was divided according to the age and season. The concentration of 25-hydroxy vitamin D (25-OH-D) was assessed with the application of the LIAISON® test using chemiluminescent immunoassay (CLIA) technology.
  
  
  RESULTS
  The mean plasma level of 25(OH)D was 14,56±7,81 ng/ml in MS patients and it was not significantly higher in women than men (15,14 ±3,29 ng/ml vs. 13,97±3,41 ng/ml, p>0,05). The lowest 25(OH)D concentration was noted in the oldest age group (9,24±4,78 ng/ml). The highest 25(OH)D concentration was noted in summer months (23,71±3,82 ng/ml).
  
  
  CONCLUSIONS
  The concentration of vitamin D in the plasma of patients with MS was significantly lower than its recommendations. Age and season of the year were the factors strongly affecting the level of 25(OH)D in MS patients.
authors.affiliation: Medical University of Lodz, Poland: Department of Hygiene of Nutrition and Epidemiology.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Godala
authors.affiliation: Medical University of Lodz, Poland: Department of Internal Diseases and Nephrodiabetology.
authors.forename: Izabela
authors.initials: I
authors.lastname: Materek-Kuśmierkiewicz
authors.affiliation: Medical University of Lodz, Poland: Department of Internal Diseases and Nephrodiabetology.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Moczulski
authors.affiliation: Medical University of Lodz, Poland: Department of Hygiene and Health Promotion.
authors.forename: Franciszek
authors.initials: F
authors.lastname: Szatko
authors.affiliation: Medical University of Lodz, Poland: Department of Hygiene and Health Promotion.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Gaszyńska
authors.affiliation: Faculty of Medicine, University of Rzeszow, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Tokarski
authors.affiliation: Medical University of Lodz, Poland: Department of Internal and Infectious Diseases.
authors.forename: Jan
authors.initials: J
authors.lastname: Kowalski
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D007118:Immunoassay; D008163:Luminescent Measurements; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D011044:Poland; D012621:Seasons; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: metabolic syndrome; seasonal variations; vitamin D