title: Laparoscopic Splenectomy for Secondary Cytoreduction in Ovarian Cancer Patients With Localized Spleen Recurrence: Feasibility and Technique.
abstract: OBJECTIVE
  To investigate the feasibility of laparoscopic splenectomy in patients with recurrent ovarian cancer with isolated spleen metastasis.
  
  
  METHODS
  (Canadian Task Force classification III).
  
  
  METHODS
  Tertiary referral centre in Rome, Italy.
  
  
  METHODS
  Eight women with an isolated platinum-sensitive splenic relapse of ovarian cancer.
  
  
  METHODS
  Between February 2013 and May 2015, 8 women with an isolated platinum-sensitive splenic relapse of ovarian cancer were submitted to laparoscopic splenectomy.
  
  
  RESULTS
  All patients underwent laparoscopic splenectomy without conversion to an open approach. The median estimated intraoperative blood loss was 100 mL (range, 50-200 mL). The median operating room time was 200 minutes (range, 80-275 mL). No intraoperative complication occurred, and no intraoperative blood transfusions were required. The median length of hospital stay was 3 days (range, 2-5 days). Complete tumor resection was achieved in all patients. The median interval from surgery to adjuvant chemotherapy was 16 days (range, 14-24 days). After a median follow-up of 23 months (range, 6-32 months), no secondary recurrence or death of disease has been observed.
  
  
  CONCLUSIONS
  Our findings indicate that a laparoscopic approach for spleen removal is feasible in selected patients with a splenic relapse of ovarian cancer when performed in a tertiary referral center by a well-trained surgeon.
authors.affiliation: Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: gallottav@gmail.com.
authors.forename: Valerio
authors.initials: V
authors.lastname: Gallotta
authors.affiliation: Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Camilla
authors.initials: C
authors.lastname: Nero
authors.affiliation: General Surgery Unit, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Lodoli
authors.affiliation: Division of Gynaecologic Oncology, Foundation John Paul II, Campobasso, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Chiantera
authors.affiliation: General Surgery Unit, Foundation John Paul II, Campobasso, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Pacelli
authors.affiliation: Division of Minimally Invasive Gynaecological Surgery, St. Maria Hospital, University of Perugia, Terni, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Fagotti
authors.affiliation: Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Costantini
authors.affiliation: Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scambia
mesh_terms: D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D065426:Cytoreduction Surgical Procedures / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D010535:Laparoscopy / Q000379:methods; D007902:Length of Stay; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D061646:Operative Time; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery*; D013156:Splenectomy / Q000379:methods; D013160:Splenic Neoplasms / Q000556:secondary / Q000601:surgery*; D016896:Treatment Outcome
keywords: Laparoscopy; recurrent ovarian cancer; splenectomy