title: Differences in Multi-Modal Ultrasound Imaging between Triple Negative and Non-Triple Negative Breast Cancer.
abstract: The objective of this study was to identify multi-modal ultrasound imaging parameters that could potentially help to differentiate between triple negative breast cancer (TNBC) and non-TNBC. Conventional ultrasonography, ultrasound strain elastography and 3-D ultrasound (3-D-US) findings from 50 TNBC and 179 non-TNBC patients were retrospectively reviewed. Immunohistochemical examination was used as the reference gold standard for cancer subtyping. Different ultrasound modalities were initially analyzed to define TNBC-related features. Subsequently, logistic regression analysis was applied to TNBC-related features to establish models for predicting TNBC. TNBCs often presented as micro-lobulated, markedly hypo-echoic masses with an abrupt interface (p = 0.015, 0.0015 and 0.004, compared with non-TNBCs, respectively) on conventional ultrasound, and showed a diminished retraction pattern phenomenon in the coronal plane (p = 0.035) on 3-D-US. Our findings suggest that B-mode ultrasound and 3-D-US in multi-modality ultrasonography could be a useful non-invasive technique for differentiating TNBCs from non-TNBCs.
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Ziyao
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: jwtian2004@163.com.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Tian
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Second Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jing
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D064726:Triple Negative Breast Neoplasms / Q000000981:diagnostic imaging*; D016217:Ultrasonography, Mammary / Q000379:methods*; D055815:Young Adult
keywords: B-mode ultrasound; Retraction pattern; Strain elastography; Three-dimensional ultrasound; Triple negative breast cancer