title: The Role and Immunobiology of Eosinophils in the Respiratory System: a Comprehensive Review.
abstract: The eosinophil is a fully delineated granulocyte that disseminates throughout the bloodstream to end-organs after complete maturation in the bone marrow. While the presence of eosinophils is not uncommon even in healthy individuals, these granulocytes play a central role in inflammation and allergic processes. Normally appearing in smaller numbers, higher levels of eosinophils in the peripheral blood or certain tissues typically signal a pathologic process. Eosinophils confer a beneficial effect on the host by enhancing immunity against molds and viruses. However, tissue-specific elevation of eosinophils, particularly in the respiratory system, can cause a variety of short-term symptoms and may lead to long-term sequelae. Eosinophils often play a role in more commonly encountered disease processes, such as asthma and allergic responses in the upper respiratory tract. They are also integral in the pathology of less common diseases including eosinophilic pneumonia, allergic bronchopulmonary aspergillosis, hypersensitivity pneumonitis, and drug reaction with eosinophilia and systemic symptoms. They can be seen in neoplastic disorders or occupational exposures as well. The involvement of eosinophils in pulmonary disease processes can affect the method of diagnosis and the selection of treatment modalities. By analyzing the complex interaction between the eosinophil and its environment, which includes signaling molecules and tissues, different therapies have been discovered and created in order to target disease processes at a cellular level. Innovative treatments such as mepolizumab and benralizumab will be discussed. The purpose of this article is to further explore the topic of eosinophilic presence, activity, and pathology in the respiratory tract, as well as discuss current and future treatment options through a detailed literature review.
authors.affiliation: Thomas Jefferson University, Philadelphia, PA, USA.|Division of Allergy and Immunology, Nemours/AI duPont Hospital for Children, Wilmington, DE, USA.
authors.forename: Stephanie S
authors.initials: SS
authors.lastname: Eng
authors.affiliation: Thomas Jefferson University, Philadelphia, PA, USA. magee.defelice@nemours.org.|Division of Allergy and Immunology, Nemours/AI duPont Hospital for Children, Wilmington, DE, USA. magee.defelice@nemours.org.
authors.forename: Magee L
authors.initials: ML
authors.lastname: DeFelice
mesh_terms: D000818:Animals; D004198:Disease Susceptibility; D004804:Eosinophils / Q000166:cytology / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007109:Immunity; D012137:Respiratory System / Q000276:immunology* / Q000378:metabolism; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy
keywords: Acute eosinophilic pneumonia; Allergic bronchopulmonary aspergillosis; Asthma endotype; Asthma phenotype; Chronic eosinophilic pneumonia; Eosinophil; Eosinophilia; Extrinsic asthma; Intrinsic asthma; Respiratory system; Severe Asthma