title: Enantioselective C-H Olefination of α-Hydroxy and α-Amino Phenylacetic Acids by Kinetic Resolution.
abstract: Significant progress has been made in the past decade regarding the development of enantioselective C-H activation reactions by desymmetrization. However, the requirement for the presence of two chemically identical prochiral C-H bonds represents an inherent limitation in scope. Reported is the first example of kinetic resolution by a palladium(II)-catalyzed enantioselective C-H activation and C-C bond formation, thus significantly expanding the scope of enantioselective C-H activation reactions.
authors.affiliation: Department of Chemistry, The Scripps Research Institution, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Kai-Jiong
authors.initials: KJ
authors.lastname: Xiao
authors.affiliation: Department of Chemistry, The Scripps Research Institution, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Chu
authors.affiliation: Department of Chemistry, The Scripps Research Institution, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA. yu200@scripps.edu.
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D007700:Kinetics; D010648:Phenylacetates / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D010648:Phenylacetates; D002244:Carbon; D006859:Hydrogen; C025136:phenylacetic acid
keywords: C−H activation; amino acids; enantioselectivity; kinetic resolution; palladium