title: Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency.
abstract: Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long-term survival of B-cells, reduced antibody production, decreased lymphocyte proliferation and defective cytokine secretion. For the first time, we reviewed the role of apoptosis in CVID and SIgAD.
authors.affiliation: Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Yazdani
authors.affiliation: Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Fatholahi
authors.affiliation: Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mazdak
authors.initials: M
authors.lastname: Ganjalikhani-Hakemi
authors.affiliation: Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran; Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at the Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Hassan
authors.initials: H
authors.lastname: Abolhassani
authors.affiliation: Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Azizi
authors.affiliation: Immunology Department, School of Public Health, Tehran University of Medical Sciences-International Campus (TUMS-IC), Tehran, Iran; Immunology Department, Faculty of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
authors.forename: Kabir Magaji
authors.initials: KM
authors.lastname: Hamid
authors.affiliation: Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
authors.affiliation: Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran. Electronic address: aghamohammadi@sina.tums.ac.ir.
authors.forename: Asghar
authors.initials: A
authors.lastname: Aghamohammadi
mesh_terms: D017209:Apoptosis / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology*; D017074:Common Variable Immunodeficiency / Q000276:immunology* / Q000473:pathology; D006801:Humans; D017098:IgA Deficiency / Q000276:immunology* / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology*
keywords: Apoptosis; Common variable immunodeficiency; IgA deficiency