title: Resistance to amoxicillin-clavulanate and its relation to virulence-related factors in Yersinia enterocolitica biovar 1A.
abstract: Recent studies have reported that the virulence factors (VFs) were detected more frequently in amoxicillin-clavulanate (AMC) susceptible clinical isolates of Escherichia coli. Here, we have evaluated the relationship between VFs and AMC-resistance phenotype in clinical isolates of Y. enterocolitica biovar 1A. The presence/absence of VFs was compared with their minimum inhibitory concentrations for AMC in strains of two serovars. We observed that the strains of the serovar O: 6, 30-6, 31 showed a similar relationship between the number of VFs and resistance to clavulanic acid as in E. coli but not of serovar O: 6, 30. Variations in the promoters/complete coding sequences (CCDSs) of β-lactamase gene (bla A) or the serological characteristics could not account for unusual susceptibility to AMC displayed by the strains of the serovar O: 6, 30. Therefore, we speculate that since the clinical strains of serovar O: 6, 30-6, 31 originated from the environment they were less exposed to antibiotics compared to clinical strains of serovar O: 6, 30. Thus, AMC susceptibility seems to be influenced by factors other than serotypes or promoters/CCDS of β-lactamase genes.
authors.forename: N
authors.initials: N
authors.lastname: Singhal
authors.forename: M
authors.initials: M
authors.lastname: Kumar
authors.affiliation: Department of Microbiology, University of Delhi, South Campus, New Delhi, India.
authors.forename: J S
authors.initials: JS
authors.lastname: Virdi
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D005798:Genes, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D017422:Sequence Analysis, DNA; D037521:Virulence Factors / Q000032:analysis* / Q000235:genetics; D015009:Yersinia Infections / Q000382:microbiology; D015008:Yersinia enterocolitica / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity*; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D037521:Virulence Factors; D019980:Amoxicillin-Potassium Clavulanate Combination; D001618:beta-Lactamases