title: miRNA and cholesterol homeostasis.
abstract: MicroRNAs (miRNAs) have recently emerged as a novel class of epigenetic regulators of gene expression. They are systemically involved in the control of lipid metabolism through a complex interactive mechanism that involves gene regulatory networks. Hence, they can contribute to defective lipid metabolism and metabolic diseases. Here, we review recent advances in the roles of lipid-sensing transcription factors in regulating miRNA gene networks, as well as miRNA expression and function in the regulation of cholesterol metabolism. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.
authors.affiliation: Department of Animal Science, Chonnam National University, Gwangju 61186, South Korea.
authors.forename: Tae-Il
authors.initials: TI
authors.lastname: Jeon
authors.affiliation: Integrative Metabolism Program, Sanford.Burnham.Prebys Medical Discovery Institute, Orlando, FL, United States. Electronic address: tosborne@sbpdiscovery.org.
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Osborne
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000235:genetics*; D004734:Energy Metabolism / Q000235:genetics; D053263:Gene Regulatory Networks / Q000235:genetics; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D008659:Metabolic Diseases / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors; D002784:Cholesterol
keywords: Cholesterol metabolism; Metabolic disease; MicroRNA; Transcription factor