title: Wheeling and Dealing With Antigen Presentation in Tuberculosis.
abstract: In tuberculosis, antigens are transferred from infected to uninfected dendritic cells. Does this favor T lymphocyte response and anti-mycobacterial host defense? In a recent report published in Cell Host & Microbe, Ernst and colleagues show that Mycobacterium tuberculosis seems to have hijacked this mechanism for its own benefit.
authors.affiliation: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 route de Narbonne BP 64182, 31000 Toulouse, France; Université de Toulouse, UPS, IPBS, 31000 Toulouse, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Hudrisier
authors.affiliation: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 route de Narbonne BP 64182, 31000 Toulouse, France; Université de Toulouse, UPS, IPBS, 31000 Toulouse, France. Electronic address: olivier.neyrolles@ipbs.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Neyrolles
mesh_terms: D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D008213:Lymphocyte Activation; D009169:Mycobacterium tuberculosis; D014376:Tuberculosis / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial
keywords: CD4 T cell; MHC class II; antigen presentation; dynamin; kinesin-2; tuberculosis