title: A New Flow-Diverter (the FloWise): In-Vivo Evaluation in an Elastase-Induced Rabbit Aneurysm Model.
abstract: OBJECTIVE
  We aimed to evaluate the efficacy and safety of a newly developed, partially retrievable flow-diverter (the FloWise) in an elastase-induced rabbit aneurysm model.
  
  
  METHODS
  We developed a partially retrievable flow diverter composed of 48 strands of Nitinol and platinum wire. The FloWise is compatible with any microcatheter of 0.027-inch inner diameter, and is retrievable up to 70% deployment. The efficacy and safety of the FloWise were evaluated in the elastase-induced rabbit aneurysm model. The rate of technical success (full coverage of aneurysm neck) and assessment of aneurysm occlusion and stent patency was conducted by angiograms and histologic examinations at the 1-month, 3-month, and 6-month follow-up. The patency of small arterial branches (intercostal or lumbar arteries) covered by the FloWise were also assessed in the 5 subjects.
  
  
  RESULTS
  We attempted FloWise insertion in a total of 32 aneurysm models. FloWise placement was successful in 31 subjects (96.9%). Two stents (6.2%) were occluded at the 3-month follow-up, but there was no evidence of in-stent stenosis in other subjects. All stented aneurysms showed progressive occlusion: grade I (complete aneurysm occlusion) in 44.4% and grade II (aneurysm occlusion > 90%) in 55.6% at 1 month; grade I in 90% and II in 10% at 3 months; and grade I in 90% and II in 10% at 6 months. All small arterial branches covered by the FloWise remained patent.
  
  
  CONCLUSIONS
  A newly developed, partially retrievable flow-diverter seems to be a safe and effective tool of aneurysm occlusion, as evaluated in the rabbit aneurysm model.
authors.affiliation: Severance Integrated Research Institute of Cerebrovascular Disease, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.; Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
authors.forename: Byung Moon
authors.initials: BM
authors.lastname: Kim
authors.affiliation: Severance Integrated Research Institute of Cerebrovascular Disease, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.; Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
authors.forename: Dong Joon
authors.initials: DJ
authors.lastname: Kim
authors.affiliation: Severance Integrated Research Institute of Cerebrovascular Disease, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.; Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
authors.forename: Dong Ik
authors.initials: DI
authors.lastname: Kim
mesh_terms: D000497:Alloys; D000783:Aneurysm / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery*; D000792:Angiography; D000818:Animals; D001158:Arteries / Q000473:pathology / Q000601:surgery; D057785:Catheters; D002560:Cerebrovascular Circulation / Q000502:physiology; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D010196:Pancreatic Elastase / Q000494:pharmacology*; D010984:Platinum; D011817:Rabbits; D015607:Stents / Q000009:adverse effects*
chemical_list: D000497:Alloys; C013616:nitinol; D010984:Platinum; D010196:Pancreatic Elastase
keywords: Aneurysm; Flow diverter; Rabbit aneurysm model