title: HPIP promotes non-small cell lung cancer cell proliferation, migration and invasion through regulation of the Sonic hedgehog signaling pathway.
abstract: Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP) has been shown to play a role in cancer development and progression. However, the role of HPIP in non-small cell lung cancer (NSCLC) has never been revealed. Here, we explore the roles and mechanisms of HPIP in the progression of NSCLC. Our results showed that HPIP expression was significantly higher in NSCLC tissues and cell lines when compared with that in normal lung tissues and cell line. In addition, knockdown of HPIP in NSCLC cells significantly inhibits the proliferation, migration and invasion in vitro and tumor growth in vivo. Furthermore, knockdown of HPIP obviously inhibits the protein expression of Shh as well as Smo, Ptc and Gli-1 in A549 cells. Taken together, these results strongly suggest that knockdown of HPIP inhibited NSCLC cell proliferation and invasion through suppressing the Sonic hedgehog signaling pathway. Thus, HPIP may be a novel potential therapeutic target for NSCLC.
authors.affiliation: Department of Oncology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China. Electronic address: oncol_jp@163.com.
authors.forename: Jia
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Oncology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China.
authors.forename: Yaguang
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Department of Oncology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China.
authors.forename: Mengwei
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D056970:Co-Repressor Proteins; D015536:Down-Regulation; D005260:Female; D053823:Hedgehog Proteins / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D043562:Receptors, G-Protein-Coupled / Q000096:biosynthesis; D000072086:Smoothened Receptor; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D000071676:Zinc Finger Protein GLI1
chemical_list: D056970:Co-Repressor Proteins; C400551:GLI1 protein, human; D053823:Hedgehog Proteins; C413449:PBXIP1 protein, human; D043562:Receptors, G-Protein-Coupled; C509239:SHH protein, human; C491023:SMO protein, human; D000072086:Smoothened Receptor; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1
keywords: Cell proliferation; Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP); Invasion; Non-small cell lung cancer (NSCLC)