title: HIV and Tfh Cells: Circulating New Ideas to Identify and Protect.
abstract: T follicular helper (Tfh) cells provide crucial support to antigen-specific B cells. In this issue of Immunity, Schultz et al. (2016) report that circulating IL-21-producing CD4(+) T cells are phenotypically, transcriptionally, and functionally similar to lymphoid Tfh cells and that such HIV-specific Tfh cells were increased in RV144 trial vaccine recipients.
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
authors.forename: Ann
authors.initials: A
authors.lastname: Chahroudi
authors.affiliation: Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA. Electronic address: gsilves@emory.edu.
authors.forename: Guido
authors.initials: G
authors.lastname: Silvestri
mesh_terms: D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007378:Interleukins / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D007378:Interleukins