title: Increased resting-state EEG functional connectivity in benign childhood epilepsy with centro-temporal spikes.
abstract: OBJECTIVE
  To explore intrahemispheric, cortico-cortical EEG functional connectivity (EEGfC) in benign childhood epilepsy with rolandic spikes (BECTS).
  
  
  METHODS
  21-channel EEG was recorded in 17 non-medicated BECTS children and 19 healthy controls. 180s of spike- and artifact-free activity was selected for EEGfC analysis. Correlation of Low Resolution Electromagnetic Tomography- (LORETA-) defined current source density time series were computed between two cortical areas (region of interest, ROI). Analyses were based on broad-band EEGfC results. Groups were compared by statistical parametric network (SPN) method. Statistically significant differences between group EEGfC values were emphasized at p<0.05 corrected for multiple comparison by local false discovery rate (FDR).
  
  
  RESULTS
  (1) Bilaterally increased beta EEGfC occurred in the BECTS group as compared to the controls. Greatest beta abnormality emerged between frontal and frontal, as well as frontal and temporal ROIs. (2) Locally increased EEGfC emerged in all frequency bands in the right parietal area.
  
  
  CONCLUSIONS
  Areas of increased EEGfC topographically correspond to cortical areas that, based on relevant literature, are related to speech and attention deficit in BECTS children.
authors.affiliation: Kenézy Gyula Hospital, Department of Neurology, Debrecen, Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Clemens
authors.affiliation: University of Debrecen, Medical Center, Department of Neurology, Debrecen, Hungary. Electronic address: szilvia.puskas@yahoo.com.
authors.forename: Szilvia
authors.initials: S
authors.lastname: Puskás
authors.affiliation: University of Debrecen, Institute of Nuclear Medicine, Debrecen, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Spisák
authors.affiliation: University of Debrecen, Institute of Nuclear Medicine, Debrecen, Hungary.
authors.forename: Imre
authors.initials: I
authors.lastname: Lajtos
authors.affiliation: University of Debrecen, Institute of Nuclear Medicine, Debrecen, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Opposits
authors.affiliation: University of Debrecen, Medical Center, Department of Pediatrics, Debrecen, Hungary.
authors.forename: Mónika
authors.initials: M
authors.lastname: Besenyei
authors.affiliation: University of Pécs, Department of Pediatrics, Pécs, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Hollódy
authors.affiliation: Epilepsy Center, Bethesda Children's Hospital, Budapest, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Fogarasi
authors.affiliation: Kenézy Gyula Hospital, Department of Neurology, Debrecen, Hungary.
authors.forename: Noémi Zsuzsanna
authors.initials: NZ
authors.lastname: Kovács
authors.affiliation: University of Debrecen, Medical Center, Department of Neurology, Debrecen, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Fekete
authors.affiliation: University of Debrecen, Institute of Nuclear Medicine, Debrecen, Hungary.
authors.forename: Miklós
authors.initials: M
authors.lastname: Emri
mesh_terms: D001931:Brain Mapping; D002648:Child; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D012146:Rest / Q000502:physiology*; D015898:Tomography Scanners, X-Ray Computed
keywords: Benign childhood epilepsy with centro-temporal spikes; EEG functional connectivity