title: LMO2 Is a Specific Marker of T-Lymphoblastic Leukemia/Lymphoma.
abstract: OBJECTIVE
  The diagnosis of T-lymphoblastic leukemia/lymphoma (T-ALL) involving the thymus can be difficult to establish since neoplastic T lymphoblasts show significant phenotypic overlap with both normal thymocytes and thymocytes from epithelial thymic neoplasms (thymomas). LIM Domain Only 2 (LMO2) gene translocations have been implicated in the pathogenesis of a small subset of T-ALLs, and LMO2 protein has recently been reported to be expressed in a large proportion of T-ALLs.
  
  
  METHODS
  In this study, we tested specificity of LMO2 for distinction between neoplastic and nonneoplastic T-precursor cells in thymus and bone marrow.
  
  
  RESULTS
  Our findings show that LMO2 is expressed in neoplastic lymphoblasts of T-ALL and is absent in thymocytes of normal thymuses or thymomas.
  
  
  CONCLUSIONS
  LMO2 is therefore a useful marker for immunophenotypic assessment of thymic neoplasms.
authors.affiliation: From the Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN. jevremovic.dragan@mayo.edu.
authors.forename: Dragan
authors.initials: D
authors.lastname: Jevremovic
authors.affiliation: From the Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN.
authors.forename: Anja C
authors.initials: AC
authors.lastname: Roden
authors.affiliation: From the Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN.
authors.forename: Rhett P
authors.initials: RP
authors.lastname: Ketterling
authors.affiliation: From the Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Kurtin
authors.affiliation: From the Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN.
authors.forename: Ellen D
authors.initials: ED
authors.lastname: McPhail
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D060588:LIM Domain Proteins / Q000378:metabolism*; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis* / Q000378:metabolism; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D013945:Thymoma / Q000175:diagnosis* / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism / Q000473:pathology; D013953:Thymus Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D060588:LIM Domain Proteins; C085117:LMO2 protein, human; D011518:Proto-Oncogene Proteins
keywords: Immunohistochemistry; LMO2; T-ALL