title: L-selectin Is Essential for Delivery of Activated CD8(+) T Cells to Virus-Infected Organs for Protective Immunity.
abstract: Cytotoxic CD8(+) T lymphocytes play a critical role in the host response to infection by viruses. The ability to secrete cytotoxic chemicals and cytokines is considered pivotal for eliminating virus. Of equal importance is how effector CD8(+) T cells home to virus-infected tissues. L-selectin has not been considered important for effector T cell homing, because levels are low on activated T cells. We report here that, although L-selectin expression is downregulated following T cell priming in lymph nodes, L-selectin is re-expressed on activated CD8(+) T cells entering the bloodstream, and recruitment of activated CD8(+) T cells from the bloodstream into virus-infected tissues is L-selectin dependent. Furthermore, L-selectin on effector CD8(+) T cells confers protective immunity to two evolutionally distinct viruses, vaccinia and influenza, which infect mucosal and visceral organs, respectively. These results connect homing and a function of virus-specific CD8(+) T cells to a single molecule, L-selectin.
authors.affiliation: Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
authors.forename: Rebar N
authors.initials: RN
authors.lastname: Mohammed
authors.affiliation: Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
authors.forename: H Angharad
authors.initials: HA
authors.lastname: Watson
authors.affiliation: Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
authors.forename: Miriam
authors.initials: M
authors.lastname: Vigar
authors.affiliation: Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
authors.forename: Julia
authors.initials: J
authors.lastname: Ohme
authors.affiliation: Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
authors.forename: Amanda
authors.initials: A
authors.lastname: Thomson
authors.affiliation: Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Humphreys
authors.affiliation: Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address: agera@cardiff.ac.uk.
authors.forename: Ann
authors.initials: A
authors.lastname: Ager
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002465:Cell Movement; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D015536:Down-Regulation; D019041:L-Selectin / Q000235:genetics / Q000378:metabolism*; D008213:Lymphocyte Activation; D051379:Mice; D009975:Orthomyxoviridae / Q000276:immunology*; D014615:Vaccinia / Q000276:immunology*
chemical_list: D019041:L-Selectin