title: Clinical presentation, allergens, and management of wheat allergy.
abstract: IgE-mediated allergy to wheat proteins can be caused by exposure through ingestion, inhalation, or skin/mucosal contact, and can affect various populations and age groups. Respiratory allergy to wheat proteins is commonly observed in adult patients occupationally exposed to flour, whereas wheat food allergy is more common in children. Wheat allergy is of growing importance for patients with recurrent anaphylaxis, especially when exercise related. The diagnosis of wheat allergy relies on a consistent clinical history, skin prick testing with well-characterized extracts and specific IgE tests. The accuracy of wheat allergy diagnosis may be improved by measuring IgE responses to several wheat components. However, a high degree of heterogeneity has been found in the recognition pattern of allergens among patient groups with different clinical profiles, as well as within each group. Thus, oral provocation with wheat or the implicated cereal is the reference test for the definitive diagnosis of ingested wheat/cereal allergy.
authors.affiliation: a Department of Allergy , Hospital La Paz Institute for Health Research (IdiPAZ) , Madrid , Spain.|b CIBER of Respiratory Diseases CIBERES , Madrid , Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Quirce
authors.affiliation: a Department of Allergy , Hospital La Paz Institute for Health Research (IdiPAZ) , Madrid , Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Boyano-Martínez
authors.affiliation: c Centro de Biotecnología y Genómica de Plantas (UPM-INIA) , Pozuelo de Alarcón , Madrid , Spain.
authors.forename: Araceli
authors.initials: A
authors.lastname: Díaz-Perales
mesh_terms: D000485:Allergens / Q000032:analysis*; D015444:Exercise; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D021182:Wheat Hypersensitivity / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*
chemical_list: D000485:Allergens; D007074:Immunoglobulin G
keywords: Cereal allergy; anaphylaxis; baker’s asthma; food allergy; wheat allergens