title: Exploring the use of nanocarrier systems to deliver the magical molecule; Curcumin and its derivatives.
abstract: Curcumin and its derivatives; curcuminoids have been proven as potential remedies in different diseases. However, their delivery carries several challenges owing to their poor aqueous solubility, photodegradation, chemical instability, poor bioavailability and rapid metabolism. This review explores and criticizes the numerous attempts that were adopted through the years to entrap/encapsulate this valuable drug in nanocarriers aiming to reach its most appropriate and successful delivery system.
authors.affiliation: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
authors.forename: Mina
authors.initials: M
authors.lastname: Mehanny
authors.affiliation: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: r_hathout@yahoo.com.
authors.forename: Rania M
authors.initials: RM
authors.lastname: Hathout
authors.affiliation: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Geneidi
authors.affiliation: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; Department of Pharmaceutical Technology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt. Electronic address: samar_holayel@yahoo.com.
authors.forename: Samar
authors.initials: S
authors.lastname: Mansour
mesh_terms: D000818:Animals; D003474:Curcumin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D004337:Drug Carriers / Q000008:administration & dosage*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage*; D036103:Nanotechnology
chemical_list: D004337:Drug Carriers; D003474:Curcumin
keywords: Curcumin; Curcuminoids; Drug delivery; Nanocarriers