title: Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients.
abstract: OBJECTIVE
  Our study investigated the association between single nucleotide polymorphisms (SNPs) in P2X7 gene and serum immunoglobulin G (IgG) responses to mycobacterium tuberculosis (MTB) in TB patients.
  
  
  METHODS
  A total of 103 TB patients were enrolled as case group and 87 healthy individuals at same geographical region as control group. The SNP detection of 1513A>C and -762T>C was performed using PCR-RFLP, and the levels of serum IgG responses to MTB in all subjects were determined.
  
  
  RESULTS
  AC and CC of 1513A>C and TC and CC of -762T>C had higher frequencies in case group than in control group. TB patients carrying TC and CC of -762T>C had higher positive rate of IgG responses to MTB than those carrying TT. Additionally, patients carrying TC and CC of -762T>C had more MTB in sputum than those carrying TT.
  
  
  CONCLUSIONS
  P2X7 SNPs, 1513A>C and -762T>C, may be associated with the susceptibility to tuberculosis, and -762T>C SNP may contribute to the development of MTB. The mutant genotype of -762T>C (TC and CC) may lower human capability of phagocytosis to MTB, leading to an increased morbidity of TB.
authors.affiliation: Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Cooperated by Education Ministry with Xinjiang Province, Shihezi University, Shihezi 832000, China.
authors.forename: Jiangdong
authors.initials: J
authors.lastname: Wu
authors.affiliation: Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Cooperated by Education Ministry with Xinjiang Province, Shihezi University, Shihezi 832000, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Lu
authors.affiliation: Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Cooperated by Education Ministry with Xinjiang Province, Shihezi University, Shihezi 832000, China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Cooperated by Education Ministry with Xinjiang Province, Shihezi University, Shihezi 832000, China.
authors.forename: Yulei
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Cooperated by Education Ministry with Xinjiang Province, Shihezi University, Shihezi 832000, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wu
authors.affiliation: Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Cooperated by Education Ministry with Xinjiang Province, Shihezi University, Shihezi 832000, China.
authors.forename: Weize
authors.initials: W
authors.lastname: Zuo
authors.affiliation: Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Cooperated by Education Ministry with Xinjiang Province, Shihezi University, Shihezi 832000, China.
authors.forename: Wanjiang
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D058486:Receptors, Purinergic P2X7 / Q000235:genetics*; D012698:Serologic Tests; D014376:Tuberculosis / Q000097:blood / Q000235:genetics* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; C546468:P2RX7 protein, human; D058486:Receptors, Purinergic P2X7