title: Changes in four plasma adipokines before and after sleep in OSAS patients.
abstract: OBJECTIVE
  This study aimed to investigate whether plasma levels of four adipokines (chemerin, macrophage migratory inhibitory factor [MIF], visceral adipose tissue-derived serine protease inhibitor [vaspin] and chemokine CXCL5) are associated with the presence of obstructive sleep apnea syndrome (OSAS) in patients.
  
  
  METHODS
  A total of 58 male patients with OSAS and 16 healthy male subjects were enrolled in this study.
  
  
  RESULTS
  Four plasma adipokines (chemerin, MIF, vaspin and chemokine CXCL5) were significantly higher (P < 0.05) in severe OSAS patients than in the control group after polysomnography. Plasma levels of these four adipokines were higher (P < 0.05) after sleep than before sleep. These levels were also associated with anthropometric measurements for BMI, neck circumference, body fat percentage, sleep parameters including the apnea/hypopnea index (AHI) and minimum SaO2%. Multiple regression analyses showed that BMI, AHI and mean SaO2% were major factors affecting the four plasma adipokine levels in OSAS patients.
  
  
  CONCLUSIONS
  Plasma chemerin, MIF, vaspin and chemokine CXCL5 levels were severely elevated with OSAS, and were also connected with obesity.
authors.affiliation: Respiratory Department, Nanjing Chest Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: Respiratory Department, Nanjing Chest Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Respiratory Department, Nanjing Chest Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
authors.forename: Siqing
authors.initials: S
authors.lastname: Sun
authors.affiliation: Respiratory Department, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D000886:Anthropometry / Q000379:methods; D050218:Body Fat Distribution; D015992:Body Mass Index; D054365:Chemokine CXCL5 / Q000097:blood; D018925:Chemokines / Q000097:blood; D006801:Humans; D000860:Hypoxia / Q000150:complications; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D039841:Leukocyte L1 Antigen Complex / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D017286:Polysomnography / Q000379:methods; D015843:Serpins / Q000097:blood; D012890:Sleep / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000503:physiopathology
chemical_list: D054392:Adipokines; D054365:Chemokine CXCL5; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D039841:Leukocyte L1 Antigen Complex; C478630:RARRES2 protein, human; C507339:SERPINA12 protein, human; D015843:Serpins
keywords: MIF; OSAS; adipokines; chemerin; chemokine CXCL5; vaspin