title: Differentiation between dogs with thrombosis and normal dogs using the overall hemostasis potential assay.
abstract: OBJECTIVE
  To determine whether the overall hemostasis potential (OHP) and calibrated automated thrombogram (CAT) were significantly different between dogs with thrombosis and normal dogs.
  
  
  METHODS
  Ten dogs with clinical evidence of thromboembolic disease had both OHP and CAT performed. Forty healthy control dogs had OHP performed, and 23 of these also had CAT performed.
  
  
  RESULTS
  Dogs with thrombosis had significantly higher OHP (P = 0.003), overall coagulation potential (P = 0.0001), and maximum optical density (Max OD, P < 0.0001) than normal dogs, and a significantly longer delay in the start of clot formation (P = 0.01). Max OD was higher than established reference intervals in 80% of the dogs with thrombosis. Using the CAT assay, dogs with thrombosis had a significantly longer lag time than normal dogs (P < 0.001). Plasma fibrinogen concentration correlated positively with overall coagulation potential, OHP, Max OD, and the slope of the OHP curve (P < 0.05), and was increased in 90% of dogs with thrombosis.
  
  
  CONCLUSIONS
  The OHP assay findings were significantly different between normal dogs and those with thrombosis. CAT did not detect any significant differences between these populations of dogs, other than the lag time of the assay.
authors.affiliation: Northern Blood Research Centre, Kolling Institute of Medical Research, University of Sydney, St Leonards, NSW, 2065, Australia.|Faculty of Veterinary Science, University of Sydney, B10, Camperdown, NSW, 2006, Australia.|North Shore Veterinary Specialist Centre, Crows Nest, NSW, 2065, Australia.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Dengate
authors.affiliation: Northern Blood Research Centre, Kolling Institute of Medical Research, University of Sydney, St Leonards, NSW, 2065, Australia.|Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Morel-Kopp
authors.affiliation: Faculty of Veterinary Science, University of Sydney, B10, Camperdown, NSW, 2006, Australia.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Beatty
authors.affiliation: Faculty of Veterinary Science, University of Sydney, B10, Camperdown, NSW, 2006, Australia.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Barrs
authors.affiliation: North Shore Veterinary Specialist Centre, Crows Nest, NSW, 2065, Australia.
authors.forename: Jody A
authors.initials: JA
authors.lastname: Braddock
authors.affiliation: North Shore Veterinary Specialist Centre, Crows Nest, NSW, 2065, Australia.
authors.forename: Richard K
authors.initials: RK
authors.lastname: Churcher
authors.affiliation: Faculty of Veterinary Science, University of Sydney, B10, Camperdown, NSW, 2006, Australia.
authors.forename: Bethany J
authors.initials: BJ
authors.lastname: Wilson
authors.affiliation: Northern Blood Research Centre, Kolling Institute of Medical Research, University of Sydney, St Leonards, NSW, 2065, Australia.|Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Ward
mesh_terms: D000818:Animals; D001780:Blood Coagulation Tests / Q000662:veterinary*; D001792:Blood Platelets / Q000502:physiology; D016022:Case-Control Studies; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs / Q000502:physiology*; D005260:Female; D006487:Hemostasis; D008297:Male; D012016:Reference Values; D013916:Thrombelastography / Q000662:veterinary; D013927:Thrombosis / Q000175:diagnosis / Q000662:veterinary*
keywords: cardiovascular; clinical pathology; coagulation; critical care; disseminated intravascular coagulation; hemostasis; pulmonary thromboembolism; respiratory tract; thromboembolism