title: Preoperative Interventional Therapy for Childhood Undifferentiated Embryonal Liver Sarcoma: Two Retrospective Cases from a Single Center.
abstract: Background Undifferentiated embryonal liver sarcoma (UELS) accounts for only 9 to 15% of all malignant liver tumors in children. Typically, UELS occurs in older children and presents as an abdominal mass. Most UELS are unresectable because of the later diagnosis. The outcome of UELS is very poor, with a 5-year overall survival of < 37.5%. Transarterial chemoembolization (TACE) has been reported to be an effective modality for unresectable liver tumors. To investigate the effects of TACE on UELS in children, we present two cases of children with UELS who underwent TACE and surgical resection in our center within the past 10 years. Methods In this study, two children with UELS were treated using TACE with cisplatin, doxorubicin, and iodized oil. The size of the tumors was measured before and after TACE using ultrasonography. Routine was also given before and after surgical resection. Side effects were recorded. Both patients had follow-up. Results After interventional therapy, both patients presented with vomiting, fever, and transient liver dysfunction without cardiac or renal dysfunction. One patient had bone marrow depression. The size of the tumors was reduced by 23% to 31% after TACE. The tumors were completely removed by surgical procedures after 4 weeks of TACE in both patients. One patient survived free of disease for 1 year, and the other survived free of disease for 9 years. Conclusion TACE yielded satisfactory results for unresectable UELS in children, with lower dosage of chemotherapy and fewer side effects. It may be applied as a preoperative therapy for children with unresectable UELS.
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Qixing
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Jinhu
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Min-Ju
authors.initials: MJ
authors.lastname: Li
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Qin
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Shoujiang
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Gu
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shu
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Jinfa
authors.initials: J
authors.lastname: Tou
keywords: child; transarterial chemoembolization; undifferentiated embryonal liver sarcoma