title: Astroglial Activation and Tau Hyperphosphorylation Precede to Neuron Loss in a Neurodegenerative Mouse Model.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu Province, China.|School of Life Sciences, Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Jin-Xing
authors.initials: JX
authors.lastname: Hou
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu Province, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Cheng
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu Province, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu Province, China.
authors.forename: Qi-Hui
authors.initials: QH
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Geriatric, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu Province, China.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu Province, China.
authors.forename: Gui-Quan
authors.initials: GQ
authors.lastname: Chen
mesh_terms: D000367:Age Factors; D053829:Amyloid Precursor Protein Secretases / Q000172:deficiency / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000235:genetics*; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000172:deficiency / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D010766:Phosphorylation / Q000235:genetics; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016564:Amyloid beta-Protein Precursor; D008562:Membrane Glycoproteins; C413604:nicastrin protein; D016875:tau Proteins; D049452:Green Fluorescent Proteins; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3; D053829:Amyloid Precursor Protein Secretases