title: Poloxamer-hydroxyethyl cellulose-α-cyclodextrin supramolecular gels for sustained release of griseofulvin.
abstract: Supramolecular gels of poloxamer-hydroxyethyl cellulose (HEC)-α-cyclodextrin (αCD) were developed aiming to obtain synergisms regarding solubilization and sustained release of griseofulvin for topical application. The effects of αCD concentration (0-10%w/w) on the phase behavior of aqueous dispersions of Pluronic(®) P123 (14%w/w) mixed with HEC (2%w/w) were evaluated at 4, 20 and 37°C. The cooperative effects of the inclusion complex formation between poly(ethylene oxide) (PEO) blocks and HEC with αCD prevented phase separation and led to supramolecular networks that solubilize the antifungal drug. Rheological and bioadhesive properties of gels with and without griseofulvin could be easily tuned modulating the polymers proportions. Supramolecular gels underwent sol-gel transition at lower temperature than P123 solely dispersions and enabled drug sustained release for at least three weeks. All gels demonstrated good biocompatibility in the HET-CAM test. Furthermore, the drug-loaded gels showed activity against Trichophyton rubrum and Trichophyton mentagrophytes and thus may be useful for the treatment of tinea capitis and other cutaneous fungal infections.
authors.affiliation: Laboratorio de Biofisicoquímica, Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, México D.F. 04510, Mexico.
authors.forename: Xelhua
authors.initials: X
authors.lastname: Marcos
authors.affiliation: Laboratorio de Biofisicoquímica, Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, México D.F. 04510, Mexico.
authors.forename: Silvia
authors.initials: S
authors.lastname: Pérez-Casas
authors.affiliation: Servicio de Microbiología y Parasitología, Complejo Hospitalario Universitario de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Llovo
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Concheiro
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address: carmen.alvarez.lorenzo@usc.es.
authors.forename: Carmen
authors.initials: C
authors.lastname: Alvarez-Lorenzo
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D065546:Drug Liberation; D005782:Gels; D006118:Griseofulvin / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D020442:Poloxamer / Q000737:chemistry*; D012212:Rheology; D012995:Solubility; D014249:Trichophyton / Q000187:drug effects; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D003692:Delayed-Action Preparations; D005782:Gels; D047391:alpha-Cyclodextrins; D020442:Poloxamer; D006118:Griseofulvin; D002482:Cellulose; C002283:hydroxyethylcellulose; C032613:alpha-cyclodextrin
keywords: Antifungal activity; Controlled release; Dermatophytosis; Hydroxyethyl cellulose; Pluronic; Supramolecular gel