title: Chronic Toxoplasmosis Modulates the Induction of Contact Hypersensitivity by TNCB in Mouse Model.
abstract: Mouse models of chronic toxoplasmosis and atopic dermatitis (AD) were combined to clarify the effect of opportunistic Toxoplasma gondii infection on the development of AD. AD was induced as a chronic contact hypersensitivity (CHS) with repeated challenge of 2,4,6-trinitro-1-chlorobenzene (TNCB) on the dorsal skin of mice. TNCB induced skin thickness increases in both normal and toxoplasmic mice. The changing patterns were different from the sigmoidal which saturated at 20 days in normal mice to the convex saturated at 12 days in toxoplasmic mice with the crossing at 18 days. Compared to normal mice, toxoplasmic mice presented CHS more severely in earlier times and then moderately in later times. These data suggest that host immune modification by T. gondii infection enhances CHS in early times of atopic stimulation but soothes the reaction of CHS in later times in mouse model.
authors.affiliation: Department of Parasitology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
authors.forename: Zhaoshou
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Parasitology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Ahn
authors.affiliation: Department of Parasitology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
authors.forename: Ho-Woo
authors.initials: HW
authors.lastname: Nam
mesh_terms: D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology* / Q000469:parasitology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D010853:Picryl Chloride / Q000009:adverse effects; D012867:Skin / Q000276:immunology / Q000469:parasitology; D014123:Toxoplasmosis / Q000276:immunology* / Q000469:parasitology
chemical_list: D010853:Picryl Chloride
keywords: Toxoplasma gondii; animal model; atopic dermatitis; contact hypersensitivity; toxoplasmosis