title: The microbial genomics of arsenic.
abstract: Arsenic, which is a major contaminant of many aquatic ecosystems worldwide, is responsible for serious public health issues. However, life has evolved various strategies for coping with this toxic element. In particular, prokaryotic organisms have developed processes enabling them to resist and metabolize this chemical. Studies based on genome sequencing and transcriptome, proteome and metabolome profiling have greatly improved our knowledge of prokaryotes' metabolic potential and functioning in contaminated environments. The increasing number of genomes available and the development of descriptive and comparative approaches have made it possible not only to identify several genetic determinants of the arsenic metabolism, but also to elucidate their phylogenetic distribution and their modes of regulation. In addition, studies using functional genomic tools have established the pleiotropic character of prokaryotes' responses to arsenic, which can be either common to several species or species-specific. These approaches also provide promising means of deciphering the functioning of microbial communities including uncultured organisms, the genetic transfers involved and the possible occurrence of metabolic interactions as well as the evolution of arsenic resistance and metabolism.
authors.affiliation: Génétique Moléculaire, Génomique et Microbiologie, UMR7156 CNRS Université de Strasbourg, 67083 Strasbourg, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Andres
authors.affiliation: Génétique Moléculaire, Génomique et Microbiologie, UMR7156 CNRS Université de Strasbourg, 67083 Strasbourg, France philippe.bertin@unistra.fr.
authors.forename: Philippe N
authors.initials: PN
authors.lastname: Bertin
mesh_terms: D001105:Archaea / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D001151:Arsenic / Q000378:metabolism*; D001419:Bacteria / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D004351:Drug Resistance / Q000235:genetics; D005786:Gene Expression Regulation; D023281:Genomics; D020071:Interspersed Repetitive Sequences; D010084:Oxidation-Reduction; D010802:Phylogeny
chemical_list: D001151:Arsenic
keywords: arsenic; community; genomics; metagenomics; prokaryote; stress