title: Observational Study of Chinese Medicine Syndrome Distribution in Patients with Acute Myocardial Infarction and Its Impact on Prognosis.
abstract: OBJECTIVE
  To investigate the distribution of Chinese medicine (CM) syndrome in patients with acute myocardial infarction (AMI) on admission and its impact on prognosis.
  
  
  METHODS
  A total of 525 AMI patients were prospectively recruited and classifified into 4 groups based on their clinical characteristics: excess-heat, excess-cold, deficiency-heat and deficiency-cold syndromes. Major adverse cardiovascular events (MACEs) were followed up.
  
  
  RESULTS
  The excess syndrome was more common than deficiency syndrome (72.95% vs. 27.05%; P<0.05). Totally 495 (94.29%) of 525 AMI patients were followed up (median 277 days). There were 59 (11.92%) MACEs. After adjusted with confounding factors in Cox regression models, the hazard ratio (95% confifidence interval) of excess-heat, excess-cold, defificiency-heat and defificiency-cold syndrome groups were 1, 1.25 (0.63, 2.49; P<0.05), 2.37 (1.14, 4.94; P<0.05), 3.76 (1.71, 8.28; P<0.05), respectively.
  
  
  CONCLUSIONS
  Excess syndrome was more common in AMI patients and had better prognosis, while defificiency-cold syndrome had the poorest prognosis. CM syndrome was of value in predicting long-term outcomes in AMI patients.
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Jing-Min
authors.initials: JM
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Xue-Juan
authors.initials: XJ
authors.lastname: Jin
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Ming-Qiang
authors.initials: MQ
authors.lastname: Fu
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Ling-Ti
authors.initials: LT
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Xiao-Tong
authors.initials: XT
authors.lastname: Cui
authors.affiliation: Department of Integrated Traditional and Western Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Integrated Traditional and Western Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Ding-Fang
authors.initials: DF
authors.lastname: Cai
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. jbge@zs-hospital.sh.cn.
authors.forename: Jun-Bo
authors.initials: JB
authors.lastname: Ge
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology; D015995:Prevalence; D011379:Prognosis; D013577:Syndrome
keywords: Chinese medicine syndrome; acute myocardial infarction; prognosis