title: Resonant X-ray emission spectroscopy of platinum(II) anticancer complexes.
abstract: Platinum-based drugs are commonly used in cancer treatment. The biological activity of a metallodrug is obviously closely related to its chemical and stereochemical characteristics. An overlooked aspect is the effect of the ligand to the electronic structure of the metal atom (coordinated atom). We report herein a Resonant X-ray Emission Spectroscopy (RXES) study on the chemical speciation of chiral platinum complexes in which diastereomers are distinguished on the basis of their metal electronic configuration. This demonstrates RXES high chemical speciation capabilities, a necessary property to further investigate the reactivity of the Pt atom towards nucleophiles or bionucleophiles, and an important complement the previously reported RXES abilities, namely that it can be employed for in situ studies at physiological concentrations.
authors.affiliation: Department of Chemistry, Ångström Laboratory, Uppsala University, Sweden. jacinto.sa@kemi.uu.se and Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Jacinto
authors.initials: J
authors.lastname: Sá
authors.affiliation: Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland and Paul Scherrer Institute (PSI), 5232 Villigen, Switzerland. jakub.szlachetko@psi.ch.
authors.forename: Joanna
authors.initials: J
authors.lastname: Czapla-Masztafiak
authors.affiliation: Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Lipiec
authors.affiliation: Paul Scherrer Institute (PSI), 5232 Villigen, Switzerland. jakub.szlachetko@psi.ch.
authors.forename: Yves
authors.initials: Y
authors.lastname: Kayser
authors.affiliation: Department of Chemistry, Ångström Laboratory, Uppsala University, Sweden. jacinto.sa@kemi.uu.se.
authors.forename: Daniel L A
authors.initials: DL
authors.lastname: Fernandes
authors.affiliation: Paul Scherrer Institute (PSI), 5232 Villigen, Switzerland. jakub.szlachetko@psi.ch and Institute of Physics, Jan Kochanowski University in Kielce, 25-406 Kielce, Poland.
authors.forename: Jakub
authors.initials: J
authors.lastname: Szlachetko
authors.affiliation: Laboratoire de Chimie Pharmaceutique Organique, Campus Plaine CP205/5, Université Libre de Bruxelles, Bd du Triomphe, B1050 Brussels, Belgium.
authors.forename: François
authors.initials: F
authors.lastname: Dufrasne
authors.affiliation: Laboratoire de Chimie Pharmaceutique Organique, Campus Plaine CP205/5, Université Libre de Bruxelles, Bd du Triomphe, B1050 Brussels, Belgium and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Gilles
authors.initials: G
authors.lastname: Berger
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry; D008024:Ligands; D009944:Organoplatinum Compounds / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009944:Organoplatinum Compounds; D005461:Fluorine