title: Current concepts on burn wound conversion-A review of recent advances in understanding the secondary progressions of burns.
abstract: Burn wound conversion describes the process by which superficial partial thickness burns convert into deeper burns necessitating surgical intervention. Fully understanding and thus controlling this phenomenon continues to defy burn surgeons. However, potentially guiding burn wound progression so as to obviate the need for surgery while still bringing about healing with limited scarring is the major unmet challenge. Comprehending the pathophysiologic background contributing to deeper progression of these burns is an essential prerequisite to planning any intervention. In this study, a review of articles examining burn wound progression over the last five years was conducted to analyze trends in recent burn progression research, determine changes in understanding of the pathogenesis of burn conversion, and subsequently examine the direction for future research in developing therapies. The majority of recent research focuses on applying therapies from other disease processes to common underlying pathogenic mechanisms in burn conversion. While ischemia, inflammation, and free oxygen radicals continue to demonstrate a critical role in secondary necrosis, novel mechanisms such as autophagy have also been shown to contribute affect significantly burn progression significantly. Further research will have to determine whether multiple mechanisms should be targeted when developing clinical therapies.
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, 200 S. Manchester Avenue, Orange, CA, 92868-3298, United States.
authors.forename: Ara A
authors.initials: AA
authors.lastname: Salibian
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, 200 S. Manchester Avenue, Orange, CA, 92868-3298, United States.
authors.forename: Angelica Tan Del
authors.initials: ATD
authors.lastname: Rosario
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, 200 S. Manchester Avenue, Orange, CA, 92868-3298, United States.
authors.forename: Lucio De Almeida Moura
authors.initials: LAM
authors.lastname: Severo
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, 200 S. Manchester Avenue, Orange, CA, 92868-3298, United States.
authors.forename: Long
authors.initials: L
authors.lastname: Nguyen
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, 200 S. Manchester Avenue, Orange, CA, 92868-3298, United States.
authors.forename: Derek A
authors.initials: DA
authors.lastname: Banyard
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, 200 S. Manchester Avenue, Orange, CA, 92868-3298, United States.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Toranto
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, 200 S. Manchester Avenue, Orange, CA, 92868-3298, United States.
authors.forename: Gregory R D
authors.initials: GRD
authors.lastname: Evans
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, 200 S. Manchester Avenue, Orange, CA, 92868-3298, United States. Electronic address: awidgero@uci.edu.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Widgerow
mesh_terms: D001343:Autophagy / Q000502:physiology; D002056:Burns / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D002921:Cicatrix; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007511:Ischemia / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology
chemical_list: D017382:Reactive Oxygen Species
keywords: Autophagy; Burn wound conversion; Secondary burn progression