title: Molecular Packing in Langmuir Monolayers Composed of a Phosphatidylcholine and a Pyrene Lipid.
abstract: Pyrene lipids are useful tools to investigate membrane organization and intracellular lipid trafficking. The molecular interactions controlling the organization of lipid monolayers composed of a cationic amphiphile tagged with a pyrene residue and a saturated or unsaturated phospholipid, namely, 1,2-dimyristoyl-sn-glycero-3-phosphocholine and 1,2-dioleoyl-sn-glycero-3-phosphocholine, were investigated by Langmuir trough isotherms to understand how the molecular structure of the components and their relative amount affect the physicochemical properties of lipid monolayers. The obtained results show that the cationic headgroups and unsaturation of hydrophobic chains strongly affect the organization of the lipid monolayer as a function of the amount of components. On the other hand, the presence of the pyrene moiety does not seem to have a marked influence on the interaction within lipid assembly.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Roma "Sapienza" , P.le Aldo Moro 5, 00185 Roma, Italy.
authors.forename: Denise
authors.initials: D
authors.lastname: Gradella Villalva
authors.affiliation: Dipartimento di Tecnologia e Salute, Istituto Superiore di Sanità , Viale Regina Elena 299, 00161 Roma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Diociaiuti
authors.affiliation: Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila , Via Vetoio, 67100 Coppito, AQ, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Giansanti
authors.affiliation: Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila , Via Vetoio, 67100 Coppito, AQ, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Petaccia
authors.affiliation: CINECA, SCAI-Super Computing Applications and Innovation Department, Via dei Tizii, 6, 00185, Rome, Italy.
authors.forename: Neva
authors.initials: N
authors.lastname: Bešker
authors.affiliation: CNR-Istituto di Metodologie Chimiche, Via Salaria km 29.300, 00016 Monterotondo Scalo, Roma, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mancini
mesh_terms: D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry*; D015394:Molecular Structure; D010713:Phosphatidylcholines / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry*
chemical_list: D008055:Lipids; D010713:Phosphatidylcholines; D011721:Pyrenes; C030984:pyrene