title: A Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels.
abstract: Allergic rhinitis is associated with elevated serum IgE levels. IgE response is mediated by the high-affinity IgE receptor (FcεRI), which is polymorphic. Studies analyzing the association between allergic rhinitis and FcεRI variants have been conducted with controversial results. The objective of this study is to analyze, in 1,041 individuals, the putative clinical association of allergic rhinitis with common polymorphisms in FcεRI subunits genes. These SNPs included FECR1A rs2494262, rs2427837 and rs2251746; FECR1B rs1441586, rs569108 and rs512555; FCER1G rs11587213, rs2070901 and rs11421. Statistically significant differences were observed for the FCER1B rs569108 and rs512555 polymorphisms frequencies when comparing patients with allergic rhinitis without asthma and controls. The OR (95% CI) value for the 237Gly allele (rs569108) is equal to 0.26 (0.08-0.86, P = 0.017) and for the G allele (rs512555) it is equal to 0.27 (0.08-0.88, P = 0.020). These two SNPs are linked (D' = 1.0, LOD = 56.05). Also observed was a statistically significant trend towards lower IgE values among allergic rhinitis patients with variant alleles for both SNPs. In conclusion, in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.
authors.affiliation: Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Amo
authors.affiliation: Allergy Service, University Hospital Infanta Cristina, Badajoz, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: García-Menaya
authors.affiliation: Allergy Service, Hospital Carlos Haya, Málaga, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Campo
authors.affiliation: Allergy Service, University Hospital Infanta Cristina, Badajoz, Spain.
authors.forename: Concepción
authors.initials: C
authors.lastname: Cordobés
authors.affiliation: Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain.|Allergy Service, Hospital Carlos Haya, Málaga, Spain.
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Plaza Serón
authors.affiliation: Research Laboratory, IBIMA-Málaga University General Hospital, Málaga, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Ayuso
authors.affiliation: Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain.
authors.forename: Gara
authors.initials: G
authors.lastname: Esguevillas
authors.affiliation: Allergy Service, Hospital Carlos Haya, Málaga, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Blanca
authors.affiliation: Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain.
authors.forename: Jose A G
authors.initials: JA
authors.lastname: Agúndez
authors.affiliation: Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: García-Martín
mesh_terms: D000483:Alleles; D001249:Asthma / Q000235:genetics / Q000276:immunology; D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide; D017455:Receptors, IgE / Q000235:genetics*; D065631:Rhinitis, Allergic / Q000235:genetics* / Q000276:immunology*
chemical_list: C502447:MS4A2 protein, human; D017455:Receptors, IgE; D007073:Immunoglobulin E