title: Mechanical loading of knee articular cartilage induced by muscle contraction can be assessed by measuring electrical potentials at the surface of the knee.
abstract: Electroarthrography (EAG) consists of recording electrical potentials on the knee surface that originate from streaming potentials within articular cartilage while the joint is undergoing compressive loading. The aim was to investigate how the contraction of specific leg muscles affects the contact force of the knee joint and, in turn, the EAG values. For six normal subjects, voluntary isometric muscle contractions were repeatedly conducted to activate four leg muscle groups while the subject was lying on his back. Two EAG signals were recorded on the medial and lateral sides of the knee, as well as four EMG signals (gastrocnemius, hamstring, quadriceps, tensor fascia latae), and the signal from a force plate fixed against the foot according to the direction of the force. The EAG and force signals were very well correlated: the median of the correlation coefficients between an EAG signal and the corresponding force signal during each loading cycle was 0.91, and 86% of the correlation coefficients were statistically significant (p<5%). Isolated muscle contraction was possible for the gastrocnemius and hamstring, but not always for the quadriceps and tensor fascia latae. Using the clinical loading protocol which consists of a one-legged stance, the quadriceps and hamstring EMGs showed minimal activity; loading cycles with increased EAG amplitude were associated with higher EMG activity from the gastrocnemius, which is involved in antero-posterior balance. These results document the role of the EAG as a "sensor" of the knee contact force and contribute to the development of clinical loading protocols with improved reproducibility.
authors.affiliation: Institut de Génie Biomédical, École Polytechnique de Montréal, Montréal, Québec, Canada.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Institut de Génie Biomédical, École Polytechnique de Montréal, Montréal, Québec, Canada.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Buschmann
authors.affiliation: Institut de Génie Biomédical, École Polytechnique de Montréal, Montréal, Québec, Canada. Electronic address: pierre.savard@polymtl.ca.
authors.forename: Pierre
authors.initials: P
authors.lastname: Savard
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000502:physiology*; D005260:Female; D006801:Humans; D007537:Isometric Contraction; D007719:Knee Joint / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D052097:Quadriceps Muscle / Q000502:physiology; D015203:Reproducibility of Results; D055815:Young Adult
keywords: Cartilage; Contact force; Electroarthrography; Knee joint; Muscles; Streaming potentials