title: Correlation and Significance of Urinary Soluble Fas and Vascular Endothelial Growth Factor in Bladder Urothelial Cancer.
abstract: OBJECTIVE
  To investigate the correlation and significance between the urine soluble Fas (sFas) and vascular endothelial growth factor (VEGF) expression in patients with urothelial bladder carcinoma (UC).
  
  
  METHODS
  The level of sFas was measured by enzyme-linked immunosorbent assay (ELISA) and the expression of VEGF protein in UC surgical specimens was screened by immunohistochemical method. These data were analyzed through SPSS 13.0 software.
  
  
  RESULTS
  The urinary sFas levels were significantly higher in the patients with UC than in those without cancer (168.0 ng/mL ± 84.6 versus 56.2 ng/mL ± 37.0; P < 0.05) and in the cases with a higher stage or grade than in those with a lower stage or grade (each P < 0.05). They had a positive relationship between the expression of VEGF protein and the pathological stage or grade in UC tissues (each P < 0.05). Spearman rank correlation test showed a significant correlation between sFas levels and VEGF expressions (R = 0.882, P < 0.05).
  
  
  CONCLUSIONS
  The effects of sFas and VEGF may play important roles together in the occurrence and progression of UC. Joint detection of urine sFas plus VEGF protein may provide valuable solutions to improve the diagnosis and treatment of UC.
authors.affiliation: Department of Andrology, First Hospital of Shijiazhuang, Shijiazhuang 050011, China; Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang 050011, China.
authors.forename: Huixiang
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Urology, Affiliated Hospital to Chengde Medical College, Chengde 067000, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang 050011, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Urology, Affiliated Hospital to Chengde Medical College, Chengde 067000, China.
authors.forename: Zemin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism* / Q000652:urine; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology / Q000652:urine*; D019459:Urothelium / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*; D019014:fas Receptor / Q000652:urine*
chemical_list: D014408:Biomarkers, Tumor; C491901:FAS protein, human; D042461:Vascular Endothelial Growth Factor A; D019014:fas Receptor