title: Bisphosphonate-related osteonecrosis of the jaws: Report of a case using conservative protocol.
abstract: Bisphosphonates have been the first-line treatment option for osteometabolic diseases, such as osteoporosis, hypercalcaemia in malignant bone diseases, and in bone metastasis. It is possible to observe a growing number of cases of osteonecrosis of the jaws in patients using this medication, called bisphosphonate-related osteonecrosis of the jaws. The purpose of this study was to report a conservative treatment for bisphosphonate-related osteonecrosis of the jaws--Stage 2, using antibacterial solution and low-level laser therapy. At the end of the treatment, the patient presented improvement of the lesion with the healing of the mucosa. The literature still lacks successful definite protocols, thus the present case may contribute with another option for conservative management for bisphosphonate-related osteonecrosis of the jaws. More research is necessary in order to develop a good protocol management for bisphosphonate-related osteonecrosis of the jaws.
authors.affiliation: Researcher, Laboratory of Biocorrosion and Biodegradation, National Institute of Technology, Rio de Janeiro, Brazil.
authors.forename: Fabiano Luiz
authors.initials: FL
authors.lastname: Heggendorn
authors.affiliation: Master Degree Student, Postgraduate Program in Pathology, Medical School, Fluminense Federal University, Rio de Janeiro, Brazil.
authors.forename: Taiana Campos
authors.initials: TC
authors.lastname: Leite
authors.affiliation: Associate Professor, Postgraduate Program in Pathology, Medical School, Fluminense Federal University, Rio de Janeiro, Brazil.
authors.forename: Karin Soares Gonçalves
authors.initials: KS
authors.lastname: Cunha
authors.affiliation: Associate Professor, Postgraduate Program in Pathology, Medical School, Fluminense Federal University, Rio de Janeiro, Brazil.
authors.forename: Arley Silva
authors.initials: AS
authors.lastname: Junior
authors.affiliation: Associate Professor, Postgraduate Program in Dentistry, Facult of Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil.
authors.forename: Lucio Souza
authors.initials: LS
authors.lastname: Gonçalves
authors.affiliation: Associate Professor of Oral Pathology, Facult of Dentistry, Fluminense Federal University, Nova Friburgo, Brazil.
authors.forename: Karla Bianca Fernandes Fontes
authors.initials: KB
authors.lastname: da Costa
authors.affiliation: Professor, Postgraduate Program in Pathology, Medical School, Fluminense Federal University, Rio de Janeiro, Brazil.
authors.forename: Eliane Pedra
authors.initials: EP
authors.lastname: Dias
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000175:diagnosis* / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged
keywords: bisphosphonates; iodides and hydrogen peroxide; low-level laser therapy; osteonecrosis