title: Acupuncture for neurogenesis in experimental ischemic stroke: a systematic review and meta-analysis.
abstract: Acupuncture has been used for patients with stroke and post-stroke rehabilitation for thousands of years. Previous studies reported that acupuncture enhanced stroke recovery through neurogenesis. Hence, we conducted a systematic review and meta-analysis for preclinical studies to assess the current evidence for acupuncture effect on neurogenesis in treating ischaemic stroke. Studies were obtained from six databases, including PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, VIP information database, and Chinese Biomedical Literature Database, Ultimately, 34 studies containing 1617 animals were identified. Neurogenesis markers of Brdu, Nestin, PSA-NCAM, NeuN and GFAP were selected as major outcomes. The pooled results of 15 studies marked with Brdu showed significant effects of acupuncture for improving proliferation when compared with control groups (P < 0.01); 13 studies marked with Nestin showed significant effects of acupuncture for increasing proliferation when compared with control groups (P < 0.01); 4 studies marked with PSA-NCAM showed significant effects of acupuncture for enhancing migration when compared with control groups (P < 0.01); 4 studies marked with NeuN showed significant effects of acupuncture for stimulating differentiation when compared with control groups (P < 0.01). The findings suggest that acupuncture is a prospective therapy targeting neurogenesis for ischemic stroke.
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.|Department of Neurology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Neurology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Zhang
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
authors.forename: Linda L D
authors.initials: LL
authors.lastname: Zhong
authors.affiliation: Department of Neurology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Zi-xian
authors.initials: ZX
authors.lastname: Chen
authors.affiliation: Department of Neurology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Guo-qing
authors.initials: GQ
authors.lastname: Zheng
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
authors.forename: Zhao-xiang
authors.initials: ZX
authors.lastname: Bian
mesh_terms: D026881:Acupuncture; D015670:Acupuncture Therapy; D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D004195:Disease Models, Animal; D006801:Humans; D055495:Neurogenesis; D017594:Publication Bias; D020521:Stroke / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers