title: NEAR-INFRARED AUTOFLUORESCENCE IN BILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION ASSOCIATED WITH ESOPHAGEAL CARCINOMA AND CHOROIDAL METASTASIS.
abstract: OBJECTIVE
  To investigate the advantage of near-infrared autofluorescence (787 nm) for the detection of melanocytic lesions in a patient with bilateral diffuse uveal melanocytic proliferation in association with esophageal carcinoma complicated by most likely unilateral choroidal metastasis.
  
  
  METHODS
  In this retrospective case report, a 55-year-old woman referred for the evaluation of sudden visual loss underwent normal ophthalmological evaluation and, in addition, was examined with near-infrared reflectance, near-infrared autofluorescence, fundus autofluorescence (Heidelberg Retina Angiograph II [HRA2; Heidelberg Engineering]), spectral domain optical coherence tomography (Spectralis OCT; Heidelberg Engineering), and multifocal electroretinography (RetiScan; Roland Consult).
  
  
  RESULTS
  The patient had been diagnosed with esophageal carcinoma 3 months before the onset of visual symptoms. The visual acuity was 20/40 in the right eye and 20/20 in the left eye. Bilateral patchy melanocytic proliferation was detected on ophthalmoscopy. The extent of lesions was best detected with near-infrared reflectance and near-infrared autofluorescence, whereas fundus autofluorescence and spectral domain optical coherence tomography did not reveal alterations of the outer retina or retinal pigment epithelium in this early stage of bilateral diffuse uveal melanocytic proliferation. The right eye showed in addition to the findings on the left eye choroidal folds in the fovea and an elevated lesion inferotemporal of the fovea suspicious of a choroidal metastasis. In the B-scan ultrasonography, a homogenous lesion was seen. Spectral domain optical coherence tomography demonstrated a mild accumulation of subretinal fluid adjacent to and over the choroidal metastasis. Transretinal biopsy of this elevated lesion revealed a low differentiated carcinoma of squamous epithelium, compatible with choroidal metastasis of the esophageal carcinoma. The choroidal metastasis increased within 3 months after the first visit. The visual acuity dropped in both eyes. The patient died 6 months after her first visit.
  
  
  CONCLUSIONS
  Bilateral diffuse uveal melanocytic proliferation can be associated with esophageal carcinoma as a systemic malignancy. Near-infrared imaging can be helpful to detect early stages of BDUMP and can help offer recently reported treatment options at an early stage of disease.
authors.affiliation: *Zentrum für seltene Netzhauterkrankungen, AugenZentrum Siegburg, MVZ ADTC Siegburg GmbH, Siegburg, Germany; †Zentrum für Augenheilkunde, Universitätsklinikum Essen, Germany; and ‡RetinaSciene, Bonn, Germany.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Golshahi
authors.forename: Norbert
authors.initials: N
authors.lastname: Bornfeld
authors.forename: Silke
authors.initials: S
authors.lastname: Weinitz
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kellner
mesh_terms: D002277:Carcinoma / Q000150:complications / Q000556:secondary*; D002830:Choroid Neoplasms / Q000150:complications / Q000556:secondary*; D004938:Esophageal Neoplasms / Q000150:complications / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008544:Melanocytes / Q000473:pathology*; D008875:Middle Aged; D061848:Optical Imaging; D012189:Retrospective Studies; D014603:Uveal Diseases / Q000209:etiology*