title: Chromophobe renal cell carcinoma occurring in the renal allograft of a transplant recipient presenting with weight loss.
abstract: The incidence of renal cell carcinomas (RCCs) in renal transplant recipients is reported as 1.1-1.5% in the native kidneys and 0.22-0.25% in the renal allograft. There are no data to support routine surveillance for tumors in transplant recipients. Most reported cases of RCCs occurring in renal allografts were incidental findings in asymptomatic patients. Herein, we report the second case of lone chromophobe RCC (ChRCC) of the renal allograft presenting with weight loss. Loss of weight is a presenting symptom in one-third of ChRCCs occurring in the native kidneys in the general population. Based on the age of the patient, R.E.N.A.L nephrometry score of the tumor and the lack of data on the prognosis of this histological subtype in a climate of long-term immunosuppression, we elected for radical nephrectomy. We suggest that RCCs should be considered in the differential diagnosis of a transplant recipient presenting with weight loss even in the absence of localizing symptoms or signs.
authors.forename: Mohammed Mahdi
authors.initials: MM
authors.lastname: Althaf
authors.forename: Mohammed S
authors.initials: MS
authors.lastname: Al-Sunaid
authors.forename: Mohamed Said
authors.initials: MS
authors.lastname: Abdelsalam
authors.forename: Lutfi A
authors.initials: LA
authors.lastname: Alkorbi
authors.forename: Turki O
authors.initials: TO
authors.lastname: Al-Hussain
authors.forename: Mohammed Anas
authors.initials: MA
authors.lastname: Dababo
authors.affiliation: Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia, .
authors.forename: Naveed
authors.initials: N
authors.lastname: Haq
mesh_terms: D044963:Biopsy, Fine-Needle; D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D009392:Nephrectomy; D013997:Time Factors; D066027:Transplant Recipients; D014184:Transplantation, Homologous; D015431:Weight Loss; D055815:Young Adult