title: microRNAs in Psoriasis.
abstract: Psoriasis is a chronic inflammatory skin condition resulting from a complex interplay among the immune system, keratinocytes, susceptibility genes, and environmental factors. However, the pathogenesis of psoriasis is not completely elucidated. microRNAs represent a promising class of small, noncoding RNA molecules that function to regulate gene expression. Although microRNA research in psoriasis and dermatology is still relatively new, evidence is rapidly accumulating for the role of microRNAs in the pathogenesis of psoriasis and other chronic inflammatory conditions. In this article, we present a comprehensive review of what is known about microRNAs and their role in the pathogenesis of psoriasis.
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Jason E
authors.initials: JE
authors.lastname: Hawkes
authors.affiliation: Department of Dermatology, University of Colorado, Aurora, Colorado, USA.
authors.forename: Giang Huong
authors.initials: GH
authors.lastname: Nguyen
authors.affiliation: Department of Dermatology, University of Colorado, Aurora, Colorado, USA.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Fujita
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Florell
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Callis Duffin
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Gerald G
authors.initials: GG
authors.lastname: Krueger
authors.affiliation: Department of Pathology, University of Utah, Salt Lake City, Utah, USA. Electronic address: ryan.oconnell@path.utah.edu.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: O'Connell
mesh_terms: D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D011565:Psoriasis / Q000235:genetics* / Q000503:physiopathology*; D012680:Sensitivity and Specificity
chemical_list: D035683:MicroRNAs