title: [The application of CRISPR/Cas9 genome editing technology in cancer research].
abstract: The CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein-9 nuclease) genome editing technology has become more and more popular in gene editing because of its simple design and easy operation. Using the CRISPR/Cas9 system, researchers can perform site-directed genome modification at the base level. Moreover, it has been widely used in genome editing in multiple species and related cancer research. In this review, we summarize the application of the CRISPR/Cas9 system in cancer research based on the latest research progresses as well as our understanding of cancer research and genome editing techniques.
authors.forename: Da-yong
authors.initials: DY
authors.lastname: Wang
authors.affiliation: Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China; Translational Medicine Research and Cooperation Center of Northern China, Harbin Medical University, Harbin 150086, China; Heilongjiang Academy of Medical Sciences, Harbin 150086, China;
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.affiliation: Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China; Translational Medicine Research and Cooperation Center of Northern China, Harbin Medical University, Harbin 150086, China; Heilongjiang Academy of Medical Sciences, Harbin 150086, China;
authors.forename: Yang
authors.initials: Y
authors.lastname: Hui
authors.affiliation: Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China; Translational Medicine Research and Cooperation Center of Northern China, Harbin Medical University, Harbin 150086, China; Heilongjiang Academy of Medical Sciences, Harbin 150086, China;
authors.forename: Xu
authors.initials: X
authors.lastname: Gao
mesh_terms: D000818:Animals; D064113:CRISPR-Cas Systems; D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D004720:Endonucleases / Q000235:genetics / Q000378:metabolism*; D016678:Genome; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D017393:RNA Editing
chemical_list: D004720:Endonucleases