title: Antibacterial drug discovery in the resistance era.
abstract: The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians, researchers, policymakers, politicians and the public at large. The evolution and widespread distribution of antibiotic-resistance elements in bacterial pathogens has made diseases that were once easily treatable deadly again. Unfortunately, accompanying the rise in global resistance is a failure in antibacterial drug discovery. Lessons from the history of antibiotic discovery and fresh understanding of antibiotic action and the cell biology of microorganisms have the potential to deliver twenty-first century medicines that are able to control infection in the resistance era.
authors.affiliation: Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4L8, Canada.|Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Brown
authors.affiliation: Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4L8, Canada.|Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
authors.forename: Gerard D
authors.initials: GD
authors.lastname: Wright
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000166:cytology / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D005798:Genes, Bacterial / Q000187:drug effects; D020043:Genes, Essential / Q000187:drug effects; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents