title: A Bioinformatic Approach for the Discovery of Antiaging Effects of Baicalein from Scutellaria baicalensis Georgi.
abstract: Aging is one of the most complicated phenomena and is the main risk factor for age-related diseases. Based on the public aging-related gene data, we propose a computational approach to predict the antiaging activities of compounds. This approach integrates network pharmacology and target fishing methods with the aim of identifying a potential antiaging compound from Scutellaria baicalensis Georgi. Utilizing this approach and subsequent experimental validation, it was found that baicalein at concentrations of 0.04, 0.2, and 1 mg/mL extended the mean, median, and maximum life spans in Drosophila melanogaster. Particularly, 0.2 mg/mL baicalein extends the mean and median life spans in male flies by 19.80% and 25.64%, respectively. Meanwhile, it was discovered that baicalein improved fertility in flies. Baicalein exerts antiaging effects likely through attenuating oxidative stress, including increases of CAT activity and GSH level and decrease of GSSG level.
authors.affiliation: 1 Modern Research Center for Traditional Chinese Medicine, Shanxi University , Taiyuan, P.R. China .
authors.forename: Li
authors.initials: L
authors.lastname: Gao
authors.affiliation: 1 Modern Research Center for Traditional Chinese Medicine, Shanxi University , Taiyuan, P.R. China .|2 College of Chemistry and Chemical Engineering, Shanxi University , Taiyuan, P.R. China .
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Duan
authors.affiliation: 1 Modern Research Center for Traditional Chinese Medicine, Shanxi University , Taiyuan, P.R. China .
authors.forename: Jian-Qin
authors.initials: JQ
authors.lastname: Zhang
authors.affiliation: 1 Modern Research Center for Traditional Chinese Medicine, Shanxi University , Taiyuan, P.R. China .
authors.forename: Yu-Zhi
authors.initials: YZ
authors.lastname: Zhou
authors.affiliation: 1 Modern Research Center for Traditional Chinese Medicine, Shanxi University , Taiyuan, P.R. China .
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Qin
authors.affiliation: 1 Modern Research Center for Traditional Chinese Medicine, Shanxi University , Taiyuan, P.R. China .|3 Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing, P.R. China .
authors.forename: Guan-Hua
authors.initials: GH
authors.lastname: Du