title: Inhibition and disintegration of insulin amyloid fibrils: a facile supramolecular strategy with p-sulfonatocalixarenes.
abstract: We reveal the ability of p-sulfonatocalix[4/6]arene to effectively inhibit the fibril formation in human insulin and demonstrate its potential to disintegrate the mature fibrils, a promising supramolecular strategy to combat amyloidosis.
authors.affiliation: Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India. jyotim@barc.gov.in and BARC-SPPU PhD Program, Department of Chemistry, Savitribai Phule Pune University, Pune, 411 007, India.
authors.forename: Meenakshi N
authors.initials: MN
authors.lastname: Shinde
authors.affiliation: Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India. jyotim@barc.gov.in.
authors.forename: Nilotpal
authors.initials: N
authors.lastname: Barooah
authors.affiliation: Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India. jyotim@barc.gov.in and Homi Bhabha National Institute, Anushaktinagar, Mumbai, India.
authors.forename: Achikanath C
authors.initials: AC
authors.lastname: Bhasikuttan
authors.affiliation: Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India. jyotim@barc.gov.in and Homi Bhabha National Institute, Anushaktinagar, Mumbai, India.
authors.forename: Jyotirmayee
authors.initials: J
authors.lastname: Mohanty
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D047250:Calixarenes / Q000737:chemistry*; D007328:Insulin / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D010636:Phenols / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D000682:Amyloid; D007328:Insulin; D010636:Phenols; C511968:p-sulfonatocalix(4)arene; D047250:Calixarenes