title: Agent-Based Modeling in Systems Pharmacology.
abstract: Modeling and simulation (M&S) techniques provide a platform for knowledge integration and hypothesis testing to gain insights into biological systems that would not be possible a priori. Agent-based modeling (ABM) is an M&S technique that focuses on describing individual components rather than homogenous populations. This tutorial introduces ABM to systems pharmacologists, using relevant case studies to highlight how ABM-specific strengths have yielded success in the area of preclinical mechanistic modeling.
authors.affiliation: York Computational Immunology LabUniversity of YorkYorkUK; Centre for Immunology and InfectionUniversity of YorkYorkUK; Department of ElectronicsUniversity of YorkYorkUK.
authors.forename: J
authors.initials: J
authors.lastname: Cosgrove
authors.affiliation: York Computational Immunology LabUniversity of YorkYorkUK; Centre for Immunology and InfectionUniversity of YorkYorkUK; Department of ElectronicsUniversity of YorkYorkUK.
authors.forename: J
authors.initials: J
authors.lastname: Butler
authors.affiliation: York Computational Immunology LabUniversity of YorkYorkUK; Centre for Immunology and InfectionUniversity of YorkYorkUK.
authors.forename: K
authors.initials: K
authors.lastname: Alden
authors.affiliation: Charles Perkins Centre University of Sydney Sydney Australia.
authors.forename: M
authors.initials: M
authors.lastname: Read
authors.affiliation: University of California School of Medicine LA Jolla California USA.
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.affiliation: GSK Medicines Research Centre Gunnels Wood Road Stevenage UK.
authors.forename: L
authors.initials: L
authors.lastname: Cucurull-Sanchez
authors.affiliation: York Computational Immunology LabUniversity of YorkYorkUK; Department of ElectronicsUniversity of YorkYorkUK; SimOmicsYorkUK.
authors.forename: J
authors.initials: J
authors.lastname: Timmis
authors.affiliation: York Computational Immunology LabUniversity of YorkYorkUK; Centre for Immunology and InfectionUniversity of YorkYorkUK; SimOmicsYorkUK.
authors.forename: M
authors.initials: M
authors.lastname: Coles