title: Current Therapy of Drugs in Amyotrophic Lateral Sclerosis.
abstract: Amyotrophic lateral sclerosis (ALS), commonly termed as motor neuron disease (MND) in UK, is a chronically lethal disorder among the neurodegenerative diseases, meanwhile. ALS is basically irreversible and progressive deterioration of upper and lower motor neurons in the motor cortex, brain stem and medulla spinalis. Riluzole, used for the treatment of ALS, was demonstrated to slightly delay the initiation of respiratory dysfunction and extend the median survival of patients by a few months. In this study, the key biochemical defects were discussed, such as: mutant Cu/Zn superoxide dismutase, mitochondrial protectants, and anti-excitotoxic/ anti-oxidative / antiinflammatory/ anti-apoptotic agents, so the related drug candidates that have been studied in ALS models would possibly be further used in ALS patients.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Lu
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Le
authors.forename: Ya-Ying
authors.initials: YY
authors.lastname: Xie
authors.affiliation: Department of Neurology, Shanghai First People's Hospital , Shanghai Jiao-Tong University, China, 200080. x_p_wang@sjtu.edu.cn.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Wang
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy* / Q000235:genetics; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D002783:Cholestenones / Q000627:therapeutic use; D000069439:Dasatinib / Q000627:therapeutic use; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000187:drug effects; D009414:Nerve Growth Factors / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D019782:Riluzole / Q000627:therapeutic use; D000072105:Superoxide Dismutase-1 / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D002783:Cholestenones; D018691:Excitatory Amino Acid Antagonists; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; C000606290:SOD1 protein, human; D019782:Riluzole; C522838:olesoxime; D000072105:Superoxide Dismutase-1; D000069439:Dasatinib