title: [Liposclerosing myxofibrous tumor of bone: a clinicopathologic analysis].
abstract: OBJECTIVE
  To explore the clinicopathologic features and imaging diagnosis of 17 cases of liposclerosing myxofibrous tumor (LSMFT) and to discuss the mechanism of the disease.
  
  
  METHODS
  Cases of LSMFT diagnosed in 2014 were included in this retrospective study. The clinicopathologic features and imaging findings were evaluated.
  
  
  RESULTS
  There were 17 cases of LSMFT, occurring in 11 men and 6 women with a mean age of 46 years (range, 26-67 years). Patients were asymptomatic or presented with pain localized over the lesions. Most (13/17) lesions were located in the intertrochanteric region. Radiographs showed well-defined and often extensively sclerotic margin. MRI showed the lesions to be relatively heterogeneous on T1W, and heterogeneous with high signal intensity on T2W with fat suppression. Microscopically, LSMFT was characterized by a complex mixture of histologic elements, including myxofibrous and collagen tissues, lipomatous areas, xanthoma cells, calcification, irregular ossification and pseudo-Paget's bone.
  
  
  CONCLUSIONS
  LSMFT is a benign fibro-ossesous lesion with unique imaging characteristics and histologic features, occurring preferentially in some locations. It might represent end-stage degenerative changes in other benign bone lesions such as fibrous dysplasia, simple bone cyst and intraosseous lipoma secondary to trauma from forces and ischemic bone injury exerted on the intertrochanteric region of the femur.
authors.affiliation: Department of Pathology, 6th People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.forename: Dingjun
authors.initials: D
authors.lastname: Hu
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Jiang
authors.forename: Huizhen
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D002114:Calcinosis; D005260:Female; D005269:Femur / Q000473:pathology; D005350:Fibroma / Q000175:diagnosis* / Q000473:pathology*; D006621:Hip Joint / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies