title: Training-related improvements in musculoskeletal health and balance: a 13-week pilot study of female cancer survivors.
abstract: Cancer survivors often experience poor post-treatment musculoskeletal health. This study examined the feasibility of combined aerobic and resistant training (CART) for improving strength, skeletal health and balance. Cancer survivors (n = 24) were identified by convenience sampling in Los Angeles County with 11 survivors consenting to 13 weeks of CART. Pre- and post-intervention assessments of bone mineral density (BMD), strength, flexibility and biomarker analysis were performed. Paired t-test analysis suggested increases in lower and upper body strength. The average T-score for BMD at the femoral neck improved from -1.46 to -1.36 and whole body BMD improved from -1.65 to -1.55. From baseline to follow-up, participants also displayed decreases in sway velocity on the eyes open (7%) and eyes closed (27%) conditions. Improvement in lower body strength was associated with increases in lean body mass (LBM) (r = 0.721) and an inverse association was observed between sway velocity and LBM (r = 0.838). Age and time since last treatment were related with biomarkers of anabolic growth (IGF-1, IGFbp-3) and bone (DPD, BAP). In summary, observed physiological changes were consistent with functional improvements, suggesting that isometric and dynamic exercise prescription may reduce the risk for falls and fall-related fractures among survivors.
authors.affiliation: Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Almstedt
authors.affiliation: Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA.|Center for Nutrition, Healthy Lifestyle, and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Grote
authors.affiliation: Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Perez
authors.affiliation: Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Shoepe
authors.affiliation: Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Strand
authors.affiliation: Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA.
authors.forename: H P
authors.initials: HP
authors.lastname: Tarleton
mesh_terms: D015502:Absorptiometry, Photon; D000058:Accidental Falls / Q000517:prevention & control; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D015519:Bone Density; D001943:Breast Neoplasms / Q000534:rehabilitation; D003110:Colonic Neoplasms / Q000534:rehabilitation; D015444:Exercise; D005081:Exercise Therapy / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006689:Hodgkin Disease / Q000534:rehabilitation; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008875:Middle Aged; D053580:Muscle Strength; D009369:Neoplasms / Q000534:rehabilitation*; D010051:Ovarian Neoplasms / Q000534:rehabilitation; D010865:Pilot Projects; D004856:Postural Balance; D011446:Prospective Studies; D016059:Range of Motion, Articular; D055070:Resistance Training; D017741:Survivors
chemical_list: D015415:Biomarkers; C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I
keywords: aerobic and resistance training; balance; cancer survivors; fall risk; musculoskeletal health