title: Multiple Integrated Complementary Healing Approaches: Energetics & Light for bone.
abstract: A synergistic-healing strategy that combines molecular targeting within a system-wide perspective is presented as the Multiple Integrated Complementary Healing Approaches: Energetics And Light (MICHAEL). The basis of the MICHAEL approach is the realization that environmental, nutritional and electromagnetic factors form a regulatory framework involved in bone and nerve healing. The interactions of light, energy, and nutrition with neural, hormonal and cellular pathways will be presented. Energetic therapies including electrical, low-intensity pulsed ultrasound and light based treatments affect growth, differentiation and proliferation of bone and nerve and can be utilized for their healing benefits. However, the benefits of these therapies can be impaired by the absence of nutritional, hormonal and organismal factors. For example, lack of sleep, disrupted circadian rhythms and vitamin-D deficiency can impair healing. Molecular targets, such as the Wnt pathway, protein kinase B and glucocorticoid signaling systems can be modulated by nutritional components, including quercetin, curcumin and Mg(2+) to enhance the healing process. The importance of water and water-regulation will be presented as an integral component. The effects of exercise and acupuncture on bone healing will also be discussed within the context of the MICHAEL approach.
authors.affiliation: Endocrine Physiology Laboratory, AVS Department, Clemson University, Clemson, SC, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Gray
authors.affiliation: Endocrine Physiology Laboratory, AVS Department, Clemson University, Clemson, SC, USA.
authors.forename: Brett R
authors.initials: BR
authors.lastname: Lackey
authors.affiliation: Endocrine Physiology Laboratory, AVS Department, Clemson University, Clemson, SC, USA; Edward Via College of Osteopathic Medicine, Spartanburg, SC, USA.
authors.forename: Evelyn F
authors.initials: EF
authors.lastname: Patrick
authors.affiliation: Endocrine Physiology Laboratory, AVS Department, Clemson University, Clemson, SC, USA. Electronic address: sngry@clemson.edu.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Gray
authors.affiliation: Trident Medical Center, Charleston, SC, USA.
authors.forename: Susan G
authors.initials: SG
authors.lastname: Hurley
mesh_terms: D001847:Bone Diseases / Q000503:physiopathology* / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D000529:Complementary Therapies / Q000379:methods*; D019317:Evidence-Based Medicine; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000379:methods*; D010789:Phototherapy / Q000379:methods*; D018511:Systems Integration; D016896:Treatment Outcome