title: Iterative reconstruction: comparison of techniques for reduced-dose liver computed tomography following transarterial chemoembolization for hepatocellular carcinoma.
abstract: Background Adaptive statistical iterative reconstruction (ASIR) and model-based iterative reconstruction (MBIR) algorithms have the potential to reduce dose while maintaining image quality. Purpose To compare computed tomography (CT) image quality and diagnostic performance among three reconstruction techniques - ASIR, MBIR, and filtered back projection (FBP) - after transcatheter arterial chemoembolization (TACE) of hepatocellular carcinomas (HCC). Material and Methods Of 60 patients that underwent initial TACE for HCCs, half underwent dynamic liver CT with conventional scanning protocol, and the other half with dose reduction to approximately 60% of conventional exposure. All images were reconstructed using three algorithms: FBP, ASIR, and MBIR. For objective analysis, image noise and signal-to-noise ratio (SNR) were compared. For subjective analysis, three radiologists independently assessed image quality. Ability to detect viable HCCs was also evaluated. Results MBIR and ASIR produced images with less noise and higher SNR compared with FBP regardless of radiation dosage ( P < 0.017). However, in terms of subjective parameters, such as image blotchiness, artifacts, and overall quality, MBIR was inferior to FBP and ASIR ( P < 0.001). Regarding diagnostic performance, there were no significant differences among reviewers in the detection of viable HCCs depending on the reconstruction algorithm, regardless of the dose reduction protocol ( P > 0.017). Conclusion Although subjective evaluations suggest that MBIR images are of lower quality compared with FBP and ASIR regardless of radiation dosage, there were no significant differences among reconstruction algorithms in diagnosis of viable HCC after TACE.
authors.affiliation: 1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Min Jae
authors.initials: MJ
authors.lastname: Cha
authors.affiliation: 1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Woo Kyoung
authors.initials: WK
authors.lastname: Jeong
authors.affiliation: 1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Dongil
authors.initials: D
authors.lastname: Choi
authors.affiliation: 1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Young Kon
authors.initials: YK
authors.lastname: Kim
authors.affiliation: 1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.|2 Department of Radiology, Hanyang University College of Medicine, Hanyang University Guri Hospital, Gyeonggi-do, Republic of Korea.
authors.forename: Sanghyeok
authors.initials: S
authors.lastname: Lim
authors.affiliation: 1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.|3 Department of Radiology, Soonchunhyang University College of Medicine, Bucheon Hospital, Gyeonggi-do, Republic of Korea.
authors.forename: Seo-Youn
authors.initials: SY
authors.lastname: Choi
authors.affiliation: 1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Won Jae
authors.initials: WJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D059629:Signal-To-Noise Ratio; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Image reconstruction; computed tomography (CT); diagnostic performance; hepatocellular carcinoma; radiation dosage; therapeutic embolization