title: Diagnostic clues for FNA diagnosis of intranodal palisaded myofibroblastoma, a rare benign lesion, an introspective case report.
abstract: Intranodal palisaded myofibroblastoma (IPM) is a benign entity, characterized by intranodal proliferation of cells of myofibroblastic origin. It has five distinct histologic features: compressed remnants of lymphoid tissue at the periphery, spindle cells with nuclear palisading, intralesional hemorrhage, amianthoid fibers, and intracellular and extracellular fuchsinophilic bodies. The spindle cells are SMA and vimentin (IHC) positive and are negative for S 100, and has a low proliferative index. Cytologic diagnosis of this lesion is a diagnostic challenge and has to be differentiated from other stroma rich lesions including schwannoma. The FNA smears were reviewed after histopathology to look for any specific features. This report highlights the variable character of spindle cells, presence of unique "amanthiod fibers" and blood vessel within cell clusters in MGG stained FNA smears, which can be a useful diagnostic clue. This observation is being reported for the first time.
authors.affiliation: Department of Pathology and Lab Medicine, Deen Dayal Upadhay Hospital, Government of NCT, Delhi, Hari Nagar, New Delhi, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Sood
mesh_terms: D000199:Actins / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D044963:Biopsy, Fine-Needle; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D009442:Neurilemmoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D009418:S100 Proteins / Q000172:deficiency / Q000235:genetics; D014746:Vimentin / Q000235:genetics
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D014408:Biomarkers, Tumor; D009418:S100 Proteins; D014746:Vimentin
keywords: Hematoxylin & Eosin(H&E); May grumwald giemsa(MGG); SMA; fine-needle aspiration cytology (FNAC); intranodal palisaded myofibroblastoma (IPM); so called amanthiod fibers; vimentin