title: Lupus pathogenesis: role of IgE autoantibodies.
abstract: IgE is commonly known for its role in the Th2 responses, protection against helminth parasites and pathogenesis of allergy. A recent report shows that IgE autoantibodies to dsDNA plays a major role in the pathogenesis of lupus nephritis by exacerbating the interferon-α responses in plasmacytoid dendritic cells.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale Unité 1138, Paris, F-75006, France.|Sorbonne Universités, UPMC Univ Paris 06, UMR S 1138, Paris, F-75006, France;|Université Paris Descartes, Sorbonne Paris Cité, UMR S 1138, Paris, F-75006, France;|Centre de Recherche des Cordeliers, Equipe - Immunopathologie et immuno-intervention thérapeutique, Paris, F-75006, France.
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D015551:Autoimmunity; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007372:Interferons / Q000378:metabolism*; D008297:Male
chemical_list: D001323:Autoantibodies; D007073:Immunoglobulin E; D007372:Interferons