title: [Relevant factors analysis on the survival of gastric cancer patients with lung metastasis].
abstract: OBJECTIVE
  To investigate the factors affecting survival rate in gastric cancer patients with lung metastasis.
  
  
  METHODS
  Clinicopathological and follow-up data of 64 gastric cancer patients with lung metastasis treated at the Cancer Hospital of Tianjin Medical University from January 1995 to December 2011, were retrospectively analyzed. The survival rate was calculated. Univariate and multivariate analysis were performed to find the factors affecting survival rate using Log-rank test and Cox proportional hazards model, respectively.
  
  
  RESULTS
  The median survival time was 7 months. The 1-, 2- and 3-year survival rates were 32.8%, 18.8% and 7.8% respectively. Univariate analysis showed that primary tumor location, type of lung metastasis, lung metastasis combined with other distant metastasis and chemotherapy were significant factors for prognosis (P<0.05). Multivariate analysis revealed that bilateral lung metastasis(HR=2.093, 95% CI: 1.092-4.014, P=0.026) and lung metastasis combined with other distant metastasis (HR=2.433, 95% CI: 1.359-4.358, P=0.003) were independent risk prognostic factors, while chemotherapy was independent protective factor(HR=0.387, 95% CI: 0.211-0.710, P=0.002).
  
  
  CONCLUSIONS
  Prognosis of gastric cancer patients with lung metastasis is quite poor, especially those with bilateral lung involvement and extra-pulmonary metastasis. Systemic chemotherapy may improve the prognosis of these patients.
authors.forename: Yuenan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. tijzhangrp@gmail.com.
authors.forename: Rupeng
authors.initials: R
authors.lastname: Zhang
authors.forename: Weijia
authors.initials: W
authors.lastname: Wang
authors.forename: Zhenchi
authors.initials: Z
authors.lastname: Ma
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xue
authors.forename: Jingyu
authors.initials: J
authors.lastname: Deng
authors.forename: Han
authors.initials: H
authors.lastname: Liang
mesh_terms: D005163:Factor Analysis, Statistical; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms; D015996:Survival Rate