title: N-terminal pro-B-type natriuretic peptide and cardiac troponin T in non-immune hydrops.
abstract: OBJECTIVE
  We analyzed the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in non-immune hydrops cases, to determine whether congestive heart failure or inadequate cardiac output may be mechanisms underlying abnormal fluid collection in hydrops.
  
  
  METHODS
  The study population consisted of singleton neonates with non-immune hydrops and healthy control neonates, matched for both gestational age at delivery and mode of delivery. The subjects were divided into three groups: group 1, hydrops of cardiac origin (n=6); group 2, hydrops of non-cardiac origin (n=17); and group 3, control (n=23). The NT-proBNP and cTnT were measured in the cord blood collected at the time of delivery.
  
  
  RESULTS
  The median cord blood concentrations of NT-proBNP and cTnT were not different between the hydrops (groups 1 and 2) or control cases. However, the NT-proBNP level was elevated in group 1 compared with groups 2 and 3. The concentrations of cTnT did not differ among the three groups.
  
  
  CONCLUSIONS
  The concentration of NT-proBNP was only elevated in cases of hydrops of cardiac origin. Congestive heart failure might not be the underlying mechanism of fluid collection in cases of non-immune hydrops of non-cardiac origin, and NT-proBNP may be a promising tool to differentiate the origin of hydrops.
authors.affiliation: Departments of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.|Department of Obstetrics and Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
authors.forename: Seung Mi
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Departments of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jong Kwan
authors.initials: JK
authors.lastname: Jun
authors.affiliation: Departments of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Su Ah
authors.initials: SA
authors.lastname: Kim
authors.affiliation: Departments of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Min Ji
authors.initials: MJ
authors.lastname: Kang
authors.affiliation: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Song
authors.affiliation: Departments of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: JoonHo
authors.initials: J
authors.lastname: Lee
authors.affiliation: Departments of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Chan-Wook
authors.initials: CW
authors.lastname: Park
authors.affiliation: Departments of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Joong Shin
authors.initials: JS
authors.lastname: Park
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002303:Cardiac Output, Low / Q000150:complications; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005865:Gestational Age; D006331:Heart Diseases / Q000151:congenital; D006333:Heart Failure / Q000150:complications; D006801:Humans; D015160:Hydrops Fetalis / Q000097:blood* / Q000209:etiology / Q000401:mortality; D007231:Infant, Newborn; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: N-terminal pro-B-type natriuretic peptide; cardiac troponin T; congenital heart disease; cord blood; non-immune hydrops