title: Unusual flavoenzyme catalysis in marine bacteria.
abstract: Ever since the discovery of the flavin cofactor more than 80 years ago, flavin-dependent enzymes have emerged as ubiquitous and versatile redox catalysts in primary metabolism. Yet, the recent advances in the discovery and characterization of secondary metabolic pathways exposed new roles for flavin-mediated catalysis in the generation of structurally complex natural products. Here, we review a selection of key biosynthetic flavoenzymes from marine bacterial secondary metabolism and illustrate how their functional and mechanistic investigation expanded our view of the cofactor's chemical repertoire and led to the discovery of a previously unknown flavin redox state.
authors.affiliation: ZBSA, Center for Biological Systems Analysis, University of Freiburg, 79104 Freiburg, Germany; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
authors.forename: Robin
authors.initials: R
authors.lastname: Teufel
authors.affiliation: Center for Oceans and Human Health, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Vinayak
authors.initials: V
authors.lastname: Agarwal
authors.affiliation: Center for Oceans and Human Health, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: bsmoore@ucsd.edu.
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Moore
mesh_terms: D001419:Bacteria / Q000201:enzymology*; D002384:Catalysis; D004798:Enzymes / Q000378:metabolism*; D005415:Flavins / Q000378:metabolism*; D008386:Marine Biology; D010084:Oxidation-Reduction
chemical_list: D004798:Enzymes; D005415:Flavins