title: Oligonucleotide-based biosensors for in vitro diagnostics and environmental hazard detection.
abstract: Oligonucleotide-based biosensors have drawn much attention because of their broad applications in in vitro diagnostics and environmental hazard detection. They are particularly of interest to many researchers because of their high specificity as well as excellent sensitivity. Recently, oligonucleotide-based biosensors have been used to achieve not only genetic detection of targets but also the detection of small molecules, peptides, and proteins. This has further broadened the applications of these sensors in the medical and health care industry. In this review, we highlight various examples of oligonucleotide-based biosensors for the detection of diseases, drugs, and environmentally hazardous chemicals. Each example is provided with detailed schematics of the detection mechanism in addition to the supporting experimental results. Furthermore, future perspectives and new challenges in oligonucleotide-based biosensors are discussed.
authors.affiliation: College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.
authors.forename: Il Young
authors.initials: IY
authors.lastname: Jung
authors.affiliation: College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.
authors.forename: Ah Young
authors.initials: AY
authors.lastname: Suh
authors.affiliation: College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.
authors.forename: Seung Jin
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea. hyukjin@ewha.ac.kr.
authors.forename: Hyukjin
authors.initials: H
authors.lastname: Lee
mesh_terms: D015374:Biosensing Techniques; D003141:Communicable Diseases / Q000175:diagnosis; D004785:Environmental Pollutants / Q000032:analysis*; D006801:Humans; D066298:In Vitro Techniques; D009369:Neoplasms / Q000175:diagnosis; D019636:Neurodegenerative Diseases / Q000175:diagnosis; D009841:Oligonucleotides / Q000737:chemistry*; D015813:Substance Abuse Detection / Q000379:methods
chemical_list: D004785:Environmental Pollutants; D009841:Oligonucleotides
keywords: Biosensors; Environmental harzard detection; In vitro diagnosis; Oligonucelotide