title: Combined large-cell neuroendocrine carcinoma and endometrioid adenocarcinoma of the endometrium: A case report and survey of related literature.
abstract: Primary large-cell neuroendocrine carcinoma of the endometrium is extremely rare and has a poor prognosis. This report describes a case of combined large-cell neuroendocrine carcinoma and endometrioid adenocarcinoma of the endometrium diagnosed as stage IIIA. The patient underwent surgery and chemotherapy and has been well with no evidence of disease for 20 months. The optimal treatment for this rare tumor has not been established. Considering its rarity and variability, it is difficult to establish an evidence-based therapeutic regimen.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Harunobu
authors.initials: H
authors.lastname: Matsumoto
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan.|Division of Obstetrics and Gynecology, Support System for Community Medicine, Oita University, Oita, Japan.
authors.forename: Kaei
authors.initials: K
authors.lastname: Nasu
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kai
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nishida
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Narahara
authors.affiliation: Diagnostic Pathology, Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Haruto
authors.initials: H
authors.lastname: Nishida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D018287:Carcinoma, Large Cell / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging
keywords: endometrioid carcinoma; endometrium; large-cell neuroendocrine carcinoma; ovary; post-therapy carcinoma