title: Severe ischemic colitis following olanzapine use - A case report.
abstract: Ischemic colitis is the most common subtype of intestinal ischemia usually resulting from vasospasm, vessel occlusion or mesenteric hypoperfusion. Neuroleptics have seldom been linked to ischemic colitis by blocking peripheral anticholinergic and antiserotonergic receptors inducing severe gastrointestinal paresis. We report a young patient with severe ischemic colitis requiring surgery due to necrosis of the bowel. After exclusion of other potential causes, olanzapine was admitted as the cause of ischemia. Clinicians should be aware of how to recognize and treat the potentially life-threatening effects of neuroleptics.
authors.affiliation: Gastrenterologia e Hepatologia, Hospital Santa Maria, Portugal.
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Fernandes
authors.affiliation: Serviço de Medicina Interna, Hospital Garcia de Orta, Portugal.
authors.forename: Rosa
authors.initials: R
authors.lastname: Alves
authors.affiliation: Serviço de Gastrenterologia e Hepatologia, Hospital Santa Maria, Portugal.
authors.forename: Luís
authors.initials: L
authors.lastname: Araújo Correia
authors.affiliation: Serviço de Gastrenterologia e Hepatologia, Hospital Santa Maria, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Rita Gonçalves
authors.affiliation: Serviço de Cirurgia Geral, Hospital Santa Maria, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Malaquias
authors.affiliation: Serviço de Anatomia Patológica, Hospital Santa Maria, Portugal.
authors.forename: Emilia
authors.initials: E
authors.lastname: Oliveira
authors.affiliation: Gastrenterologia e Hepatologia, Hospital de Santa Maria, Portugal.
authors.forename: José
authors.initials: J
authors.lastname: Velosa
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical; D001321:Autistic Disorder / Q000150:complications / Q000188:drug therapy; D001569:Benzodiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D017091:Colitis, Ischemic / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D003113:Colonoscopy; D006801:Humans; D008297:Male; D000077152:Olanzapine; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D001569:Benzodiazepines; D000077152:Olanzapine; D017367:Selective Serotonin Reuptake Inhibitors