title: Antimicrobial Activity of Silver Ions Released from Zeolites Immobilized on Cellulose Nanofiber Mats.
abstract: In this study, we exploit the high silver ion exchange capability of Linde Type A (LTA) zeolites and present, for the first time, electrospun nanofiber mats decorated with in-house synthesized silver (Ag(+)) ion exchanged zeolites that function as molecular delivery vehicles. LTA-Large zeolites with a particle size of 6.0 μm were grown on the surface of the cellulose nanofiber mats, whereas LTA-Small zeolites (0.2 μm) and three-dimensionally ordered mesoporous-imprinted (LTA-Meso) zeolites (0.5 μm) were attached to the surface of the cellulose nanofiber mats postsynthesis. After the three zeolite/nanofiber mat assemblies were ion-exchanged with Ag(+) ions, their ion release profiles and ability to inactivate Escherichia coli (E. coli) K12 were evaluated as a function of time. LTA-Large zeolites immobilized on the nanofiber mats displayed more than an 11 times greater E. coli K12 inactivation than the Ag-LTA-Large zeolites that were not immobilized on the nanofiber mats. This study demonstrates that by decorating nanometer to micrometer scale Ag(+) ion-exchanged zeolites on the surface of high porosity, hydrophilic cellulose nanofiber mats, we can achieve a tunable release of Ag(+) ions that inactivate bacteria faster and are more practical to use in applications over powder zeolites.
authors.affiliation: Department of Chemical Engineering, University of Massachusetts Amherst , Amherst, Massachusetts 01003-9303, United States.
authors.forename: Katrina A
authors.initials: KA
authors.lastname: Rieger
authors.affiliation: Department of Chemical Engineering, University of Massachusetts Amherst , Amherst, Massachusetts 01003-9303, United States.
authors.forename: Hong Je
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Department of Chemical Engineering, University of Massachusetts Amherst , Amherst, Massachusetts 01003-9303, United States.
authors.forename: Hiu Fai
authors.initials: HF
authors.lastname: Yeung
authors.affiliation: Department of Chemical Engineering, University of Massachusetts Amherst , Amherst, Massachusetts 01003-9303, United States.
authors.forename: Wei
authors.initials: W
authors.lastname: Fan
authors.affiliation: Department of Chemical Engineering, University of Massachusetts Amherst , Amherst, Massachusetts 01003-9303, United States.
authors.forename: Jessica D
authors.initials: JD
authors.lastname: Schiffman
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002482:Cellulose / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007477:Ions / Q000737:chemistry; D057139:Nanofibers / Q000737:chemistry* / Q000627:therapeutic use; D012834:Silver / Q000737:chemistry*; D017641:Zeolites / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D007477:Ions; D017641:Zeolites; D012834:Silver; D002482:Cellulose
keywords: antibacterial; electrospin; nanofiber; silver; zeolite