title: Prophylaxis against hepatitis E: at risk populations and human vaccines.
abstract: Hepatitis E is an emerging global disease caused by hepatitis E virus (HEV) infection. While in developing countries the infection was primarily due to poor sanitary conditions through intake of contaminated water or undercooked meats of infected animals, increasing cases of chronic hepatitis E resulting in rapidly progressive liver cirrhosis and end-stage liver disease have been reported in organ transplant patients or in immune compromised patients in developed countries. Fortunately, hepatitis E is now a vaccine preventable disease with a HEV239 based vaccine licensed for human use. Much work is needed to enable its use outside China. This review recounted the development process of the vaccine, outlined the critical quality attributes of the vaccine antigen and, most importantly, listed the populations at risk for HEV infection and the subsequent disease. These at risk populations could benefit the most from the vaccination if the vaccine is widely adopted.
authors.affiliation: a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases , Xiamen University , Xiamen , PR China.|b School of Public Health , Xiamen University , Xiamen , PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases , Xiamen University , Xiamen , PR China.|b School of Public Health , Xiamen University , Xiamen , PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases , Xiamen University , Xiamen , PR China.|b School of Public Health , Xiamen University , Xiamen , PR China.|c School of Life Science , Xiamen University , Xiamen , PR China.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases , Xiamen University , Xiamen , PR China.|b School of Public Health , Xiamen University , Xiamen , PR China.|c School of Life Science , Xiamen University , Xiamen , PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wu
authors.affiliation: a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases , Xiamen University , Xiamen , PR China.|b School of Public Health , Xiamen University , Xiamen , PR China.|c School of Life Science , Xiamen University , Xiamen , PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases , Xiamen University , Xiamen , PR China.|b School of Public Health , Xiamen University , Xiamen , PR China.|c School of Life Science , Xiamen University , Xiamen , PR China.
authors.forename: Ningshao
authors.initials: N
authors.lastname: Xia
authors.affiliation: a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases , Xiamen University , Xiamen , PR China.|b School of Public Health , Xiamen University , Xiamen , PR China.
authors.forename: Qinjian
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D002681:China; D016751:Hepatitis E / Q000453:epidemiology* / Q000517:prevention & control*; D006801:Humans; D018570:Risk Assessment; D014765:Viral Vaccines / Q000276:immunology* / Q000302:isolation & purification*
chemical_list: D014765:Viral Vaccines
keywords: Hepatitis E virus; antigenic determinants; capsid protein; critical product attributes; neutralizing epitopes; prophylactic vaccine; vaccination