title: Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis.
abstract: Arboviruses are pathogens that widely affect the health of people in different communities around the world. Recently, a few successful approaches toward production of effective vaccines against some of these pathogens have been developed, but treatment and prevention of the resulting diseases remain a major health and research concern. The arbovirus infection and replication processes are complex, and many factors are involved in their regulation. Apoptosis, autophagy and the unfolded protein response (UPR) are three mechanisms that are involved in pathogenesis of many viruses. In this review, we focus on the importance of these pathways in the arbovirus replication and infection processes. We provide a brief introduction on how apoptosis, autophagy and the UPR are initiated and regulated, and then discuss the involvement of these pathways in regulation of arbovirus pathogenesis.
authors.affiliation: Zoonotic Diseases and Special Pathogens,National Microbiology Laboratory,Public Health Agency of Canada,1015 Arlington St.,Winnipeg,Manitoba,Canada.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Iranpour
authors.affiliation: Young Researchers and Elite Club,Ardabil Branch,Islamic Azad University,Ardabil,Iran.
authors.forename: Adel Rezaei
authors.initials: AR
authors.lastname: Moghadam
authors.affiliation: Faculty of Veterinary Medicine,University of Tehran,Tehran,Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Yazdi
authors.affiliation: Department of Internal Medicine,College of Medicine,Faculty of Health Sciences,University of Manitoba,Winnipeg,Canada.
authors.forename: Sudharsana R
authors.initials: SR
authors.lastname: Ande
authors.affiliation: Department of Human Anatomy and Cell Science,College of Medicine,Faculty of Health Sciences,University of Manitoba,Winnipeg,Canada.
authors.forename: Javad
authors.initials: J
authors.lastname: Alizadeh
authors.affiliation: Department of Clinical and Experimental Medicine (IKE),Division of Otorhinolaryngology,Linkoping University,Linkoping,Sweden.
authors.forename: Emilia
authors.initials: E
authors.lastname: Wiechec
authors.affiliation: Zoonotic Diseases and Special Pathogens,National Microbiology Laboratory,Public Health Agency of Canada,1015 Arlington St.,Winnipeg,Manitoba,Canada.
authors.forename: Robbin
authors.initials: R
authors.lastname: Lindsay
authors.affiliation: Zoonotic Diseases and Special Pathogens,National Microbiology Laboratory,Public Health Agency of Canada,1015 Arlington St.,Winnipeg,Manitoba,Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Drebot
authors.affiliation: Department of Medical Microbiology and Infectious Diseases,College of Medicine,Faculty of Health Sciences,University of Manitoba,Winnipeg,Manitoba,Canada.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Coombs
authors.affiliation: Department of Human Anatomy and Cell Science,College of Medicine,Faculty of Health Sciences,University of Manitoba,Winnipeg,Canada.
authors.forename: Saeid
authors.initials: S
authors.lastname: Ghavami
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D001096:Arachnid Vectors / Q000821:virology; D001102:Arbovirus Infections / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology* / Q000821:virology; D001103:Arboviruses / Q000472:pathogenicity* / Q000502:physiology; D001343:Autophagy / Q000235:genetics; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D008322:Mammals / Q000821:virology; D015398:Signal Transduction; D056811:Unfolded Protein Response; D015047:Zoonoses / Q000453:epidemiology / Q000635:transmission / Q000821:virology
chemical_list: D051017:Apoptosis Regulatory Proteins; D018797:Cell Cycle Proteins