title: Adjuvant treatment with a dialyzable leukocytes extract contributes to maintain HPV-infected women free of low-grade cervical lesions.
abstract: OBJECTIVE
  To investigate if adjuvant treatment with a dialyzable extract of leukocytes (DLE), may help HPV-infected patients with low-grade intraepithelial squamous cervical lesions (LIS) to get free of HPV infection and cervical lesions.
  
  
  METHODS
  Patients with untreated, low-grade cervical lesions were treated either with surgery (Group A) or with DLE (Group B). Pa- tients with low-grade but recurrent cervical lesions were newly treated with surgery plus DLE (Group C).
  
  
  RESULTS
  A decreased or ab- sent cervical lesion correlated with a diminished or absent HPV viral load at one year of treatment (r = 0.6,p <0.05). Seventy-nine percent of Group B but only 50 % of Group C and 38 % of Group A patients were free of cervical lesion after 24 months of treatment (p < 0.05).
  
  
  CONCLUSIONS
  The present data support the benefit of adding DLE as adjuvant for treating HPV-infected women with LIS.
authors.forename: A
authors.initials: A
authors.lastname: Rodriguez-Flores
authors.forename: G
authors.initials: G
authors.lastname: Nuñez-Fernandez
authors.forename: I
authors.initials: I
authors.lastname: Estrada-Garcia
authors.forename: M
authors.initials: M
authors.lastname: Aguilar-Santelises
authors.forename: O
authors.initials: O
authors.lastname: Rojas-Espinosa
authors.forename: S
authors.initials: S
authors.lastname: Estrada-Parra
mesh_terms: D000293:Adolescent; D000328:Adult; D002457:Cell Extracts / Q000627:therapeutic use*; D003956:Dialysis; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000628:therapy*; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control* / Q000821:virology; D019562:Viral Load; D002578:Uterine Cervical Dysplasia / Q000517:prevention & control* / Q000821:virology
chemical_list: D002457:Cell Extracts