title: Effect of systemically increasing human full-length Klotho on glucose metabolism in db/db mice.
abstract: The metabolic effects of antiaging Klotho were previously investigated in vivo by genetic manipulation. We have here studied the metabolic effect of physiologic levels of circulating full length Klotho in db/db mice. Increasing the full-length human Klotho levels has a positive effect on blood glucose through increasing insulin secretion.
authors.affiliation: The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden. Electronic address: Elisabete.forsberg@ki.se.
authors.forename: E A
authors.initials: EA
authors.lastname: Forsberg
authors.affiliation: Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Olauson
authors.affiliation: Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Larsson
authors.affiliation: The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden; Department of Endocrinology, Diabetes and Metabolism, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: S B
authors.initials: SB
authors.lastname: Catrina
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000628:therapy*; D015316:Genetic Therapy; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D007328:Insulin / Q000097:blood; D000090265:Klotho Proteins; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: Glucose; Insulin and db/db mouse; Klotho; Liver