title: Design and optimization of pulsed Chemical Exchange Saturation Transfer MRI using a multiobjective genetic algorithm.
abstract: Pulsed Chemical Exchange Saturation Transfer (CEST) MRI experimental parameters and RF saturation pulse shapes were optimized using a multiobjective genetic algorithm. The optimization was carried out for RF saturation duty cycles of 50% and 90%, and results were compared to continuous wave saturation and Gaussian waveform. In both simulation and phantom experiments, continuous wave saturation performed the best, followed by parameters and shapes optimized by the genetic algorithm and then followed by Gaussian waveform. We have successfully demonstrated that the genetic algorithm is able to optimize pulse CEST parameters and that the results are translatable to clinical scanners.
authors.affiliation: Department of Medical Imaging, University of Arizona, Tucson, AZ, USA.
authors.forename: Eriko S
authors.initials: ES
authors.lastname: Yoshimaru
authors.affiliation: Department of Medical Imaging, University of Arizona, Tucson, AZ, USA.
authors.forename: Edward A
authors.initials: EA
authors.lastname: Randtke
authors.affiliation: Department of Medical Imaging, University of Arizona, Tucson, AZ, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Pagel
authors.affiliation: Department of Medical Imaging, University of Arizona, Tucson, AZ, USA. Electronic address: cardenaj@email.arizona.edu.
authors.forename: Julio
authors.initials: J
authors.lastname: Cárdenas-Rodríguez
mesh_terms: D000465:Algorithms; D000643:Ammonium Chloride / Q000737:chemistry; D003287:Contrast Media; D007090:Image Interpretation, Computer-Assisted; D007472:Iohexol / Q000031:analogs & derivatives / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D016011:Normal Distribution; D019047:Phantoms, Imaging; D011846:Radio Waves; D020156:Salicylic Acid / Q000737:chemistry
chemical_list: D003287:Contrast Media; D000643:Ammonium Chloride; D007472:Iohexol; C038192:iopromide; D020156:Salicylic Acid
keywords: Chemical Exchange Saturation Transfer; Genetic algorithm; Iopromide; Pulse design; Pulsed CEST MRI; Salicylic acid; Shaped pulses