title: ANTINFLAMMATORY ACTIVITY OF AN N, N'-DISALICYLIDENEMETHYLENDIAMINE-DERIVED SCHIFF BIS BASE AND ITS COPPER(II) COMPLEX.
abstract: OBJECTIVE
  The cooper(II) complex combination of N, N'-disalicylidenemethylenediamine and the Schiff bis base were investigated for anti-inflammatory activity.
  
  
  METHODS
  In vivo, the anti-inflammatory activity of the metallic complex in comparison with the activity of the Schiff bis base was tested by the method of Winter and co-workers using the Levy technique.
  
  
  CONCLUSIONS
  Our study on the anti-inflammatory activity of a new Schiff bis base and its complex cooper(II) combination showed that the Schiff bis bases exhibited significant anti-inflammatory action in acute experimental inflammation when compared to the control group. The copper cation from the complex combination enhanced the anti-inflammatory effect of the Schiff bis base, the effect being stronger at doses of 10 mg/kg cooper(II) complex.
  
  
  CONCLUSIONS
  The Schiff bis base and its cooper(II) complex had an anti-inflammatory effect comparable to that of indomethacin.
authors.forename: Gladiola
authors.initials: G
authors.lastname: Tântaru
authors.forename: M
authors.initials: M
authors.lastname: Nechifor
authors.forename: M
authors.initials: M
authors.lastname: Apostu
authors.forename: Mădălina
authors.initials: M
authors.lastname: Vieriu
authors.forename: Alina Diana
authors.initials: AD
authors.lastname: Panainte
authors.forename: Nela
authors.initials: N
authors.lastname: Bibire
mesh_terms: D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D012545:Schiff Bases / Q000138:chemical synthesis*; D014131:Trace Elements / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D003959:Diamines; D012545:Schiff Bases; D014131:Trace Elements; D003300:Copper