title: [Renal artery injury caused by Kawasaki disease].
abstract: OBJECTIVE
  To investigate renal artery injury caused by Kawasaki disease (KD).
  
  
  METHODS
  Forty-three children with KD were enrolled in the study. According to the blood pressure in the acute stage, these children were classified into normal blood pressure subgroup and increased blood pressure subgroup. Eighteen children with fever caused by acute upper respiratory tract infection were enrolled as the control group. The diameter of the origin of the main renal artery, hemodynamic parameters of the main renal artery and the renal interlobar artery, rennin activity, and levels of angiotensin II and aldosterone were compared between groups.
  
  
  RESULTS
  During the acute stage of KD, both subgroups had a significantly smaller diameter of the origin of the main renal artery, a significantly higher resistance index (RI) of the main renal artery, and a significantly lower end-diastolic velocity (EDV) than the control group (P<0.05).The increased blood pressure subgroup had a significantly lower EDV of the interlobar artery than the normal blood pressure subgroup, a significantly higher RI than the normal blood pressure subgroup and the control group, as well as a significantly higher rennin activity and significantly higher levels of angiotensin II and aldosterone than the normal blood pressure subgroup (P<0.05). A significantly increased EDV and a significantly reduced RI of the renal interlobar artery were observed in the increased blood pressure subgroup in the subacute stage compared with the acute stage (P<0.05).
  
  
  CONCLUSIONS
  KD may cause renal artery injury and early hemodynamic changes, resulting in a transient increase in blood pressure in some patients.
authors.affiliation: Department of Pediatrics, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China. zmh1962cn@163.com.
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Jun-Chu
authors.initials: JC
authors.lastname: Chen
authors.forename: Li-Ling
authors.initials: LL
authors.lastname: Zhu
authors.forename: Min
authors.initials: M
authors.lastname: Liang
authors.forename: Yun
authors.initials: Y
authors.lastname: Peng
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000503:physiopathology*; D012077:Renal Artery / Q000503:physiopathology*; D012084:Renin-Angiotensin System / Q000502:physiology; D014655:Vascular Resistance