title: Modulation of Hypercholesterolemia-Induced Oxidative/Nitrative Stress in the Heart.
abstract: Hypercholesterolemia is a frequent metabolic disorder associated with increased risk for cardiovascular morbidity and mortality. In addition to its well-known proatherogenic effect, hypercholesterolemia may exert direct effects on the myocardium resulting in contractile dysfunction, aggravated ischemia/reperfusion injury, and diminished stress adaptation. Both preclinical and clinical studies suggested that elevated oxidative and/or nitrative stress plays a key role in cardiac complications induced by hypercholesterolemia. Therefore, modulation of hypercholesterolemia-induced myocardial oxidative/nitrative stress is a feasible approach to prevent or treat deleterious cardiac consequences. In this review, we discuss the effects of various pharmaceuticals, nutraceuticals, some novel potential pharmacological approaches, and physical exercise on hypercholesterolemia-induced oxidative/nitrative stress and subsequent cardiac dysfunction as well as impaired ischemic stress adaptation of the heart in hypercholesterolemia.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Szeged, Dóm tér 9, Szeged 6720, Hungary.
authors.forename: Csaba
authors.identifier: 0000-0003-2532-6261
authors.initials: C
authors.lastname: Csonka
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Szeged, Dóm tér 9, Szeged 6720, Hungary.
authors.forename: Márta
authors.initials: M
authors.lastname: Sárközy
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Szeged, Dóm tér 9, Szeged 6720, Hungary.
authors.forename: Márton
authors.initials: M
authors.lastname: Pipicz
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Szeged, Dóm tér 9, Szeged 6720, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Dux
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Szeged, Dóm tér 9, Szeged 6720, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Csont
mesh_terms: D006801:Humans; D006937:Hypercholesterolemia / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D018384:Oxidative Stress; D026361:Reactive Nitrogen Species / Q000378:metabolism*
chemical_list: D026361:Reactive Nitrogen Species