title: Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy.
abstract: Hypertrophic osteoarthrpathy (HO) is a rare paraneoplasic syndrome associated with non-small cell lung cancer (NSCLC). The pathophysiology of HO is unknown but was recently related to enhanced levels of urine prostaglandin E2 (PGE2). Here, we report the case of a patient that presented HO in association with a resectable left upper lobe NSCLC. Following surgery and adjuvant chemotherapy, HO resolved and did not recur with development of a brain metastasis 1 year later. Interestingly, tumor cyclooxygenase-2, an enzyme responsible the synthesis of PGE2, was expressed in the primary tumor but not in the resected metastasis.
authors.affiliation: Hôpital Cantonal de Fribourg, Service de Chirurgie, Fribourg, Switzerland.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Rotas
authors.affiliation: Réseau Santé Valais, Hôpital de Sion, Service de Chirurgie, Sion, Switzerland.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cito
authors.affiliation: Centre Hospitalier Universitaire Vaudois, Département de Pathologie, Lausanne, Switzerland.
authors.forename: Igor
authors.initials: I
authors.lastname: Letovanec
authors.affiliation: Réseau Santé Valais, Hôpital de Sion, Service de Chirurgie, Sion, Switzerland.
authors.forename: Michel
authors.initials: M
authors.lastname: Christodoulou
authors.affiliation: Centre Hospitalier Universitaire Vaudois, Département de Chirurgie Thoracique, Lausanne, Switzerland. Electronic address: jean.perentes@chuv.ch.
authors.forename: Jean Y
authors.initials: JY
authors.lastname: Perentes
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000096:biosynthesis*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000378:metabolism*; D010257:Paraneoplastic Syndromes / Q000378:metabolism*
chemical_list: D051546:Cyclooxygenase 2