title: The future of endovascular treatment: Insights from the ESCAPE investigators.
abstract: The ESCAPE trial demonstrated strong morbidity benefit and mortality reduction for endovascular stroke treatment. Following the release of the main results, the ESCAPE trial investigators convened at a 2-day close-out meeting in March 2015 in Banff, Alberta, Canada. Meeting discussions focused on system implications, procedural characteristics, and future directions. We report the proceedings of the meeting, which provide insights from the trialists into the issues of generalizability, treatment limitations, as well as future directions and opportunities in stroke care optimization.
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
authors.forename: Evgenia
authors.initials: E
authors.lastname: Klourfeld
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Zerna
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
authors.forename: Fahad S
authors.initials: FS
authors.lastname: Al-Ajlan
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
authors.forename: Noreen
authors.initials: N
authors.lastname: Kamal
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
authors.forename: Privia
authors.initials: P
authors.lastname: Randhawa
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
authors.forename: Amy Y
authors.initials: AY
authors.lastname: Yu
authors.affiliation: Department of Medicine (Neurology), the Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Dar
authors.initials: D
authors.lastname: Dowlatshahi
authors.affiliation: Beaumont Hospital, Dublin, Ireland.
authors.forename: John
authors.initials: J
authors.lastname: Thornton
authors.affiliation: Department of Geriatric and Stroke Medicine, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland.
authors.forename: David
authors.initials: D
authors.lastname: Williams
authors.affiliation: Medical University of South Carolina, Charlston, SC, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Holmstedt
authors.affiliation: Royal Saskatchewan Hospital, University of Saskatchewan, Saskatoon, SK, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Kelly
authors.affiliation: Swedish Medical Center, Colorado Neurological Institute, Denver, CO, USA.
authors.forename: Donald
authors.initials: D
authors.lastname: Frei
authors.affiliation: Department of Neurology, Erlanger Hospital, Chattanooga, TN, USA.
authors.forename: Blaise
authors.initials: B
authors.lastname: Baxter
authors.affiliation: Departments of Neurology, Neurosurgery and Radiology, Temple University, Philadelphia, PA, USA.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Linares
authors.affiliation: Department of Neurology, Samsung Medical Center, Seoul, Korea.
authors.forename: Oh Young
authors.initials: OY
authors.lastname: Bang
authors.affiliation: Department of Neurosciences, Université de Montréal, Montréal, QC, Canada.
authors.forename: Alexandre Y
authors.initials: AY
authors.lastname: Poppe
authors.affiliation: Department of Radiology, University of Toronto, Toronto, ON, Canada.
authors.forename: Walter
authors.initials: W
authors.lastname: Montanera
authors.affiliation: Department of Radiology, University of Alberta, Edmonton, AB, Canada.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Rempel
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada Department of Radiology, University of Calgary, Calgary, AB, Canada.
authors.forename: Muneer
authors.initials: M
authors.lastname: Eesa
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
authors.forename: Bijoy K
authors.initials: BK
authors.lastname: Menon
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Demchuk
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada Department of Radiology, University of Calgary, Calgary, AB, Canada.
authors.forename: Mayank
authors.initials: M
authors.lastname: Goyal
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada Department of Radiology, University of Calgary, Calgary, AB, Canada Department of Medicine, University of Calgary, Calgary, AB, Canada Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada michael.hill@ucalgary.ca.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hill
mesh_terms: D057510:Endovascular Procedures / Q000379:methods / Q000639:trends*; D005544:Forecasting; D006801:Humans; D018579:Patient Selection; D015607:Stents; D020521:Stroke / Q000628:therapy*; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
chemical_list: D010959:Tissue Plasminogen Activator
keywords: Acute stroke therapy; cerebral infarction; intervention; ischemic stroke; recombinant tissue plasminogen activator; stenting; therapy; thrombolysis