title: Eukaryote-specific extensions in ribosomal proteins of the small subunit: Structure and function.
abstract: High-resolution structures of yeast ribosomes have improved our understanding of the architecture and organization of eukaryotic rRNA and proteins, as well as eukaryote-specific extensions present in some conserved ribosomal proteins. Despite this progress, assignment of specific functions to individual proteins and/or eukaryote-specific protein extensions remains challenging. It has been suggested that eukaryote-specific extensions of conserved proteins from the small ribosomal subunit may facilitate eukaryote-specific reactions in the initiation phase of protein synthesis. This review summarizes emerging data describing the structural and functional significance of eukaryote-specific extensions of conserved small ribosomal subunit proteins, particularly their possible roles in recruitment and spatial organization of eukaryote-specific initiation factors.
authors.affiliation: Center for Gene Regulation in Health and Disease; Department of Biological, Geological and Environmental Sciences; Cleveland State University ; Cleveland, OH USA.
authors.forename: Arnab
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Center for Gene Regulation in Health and Disease; Department of Biological, Geological and Environmental Sciences; Cleveland State University ; Cleveland, OH USA.
authors.forename: Anton A
authors.initials: AA
authors.lastname: Komar
keywords: conserved ribosomal proteins; eukaryote-specific extensions; eukaryotic translation initiation factors; eukaryotic/yeast ribosome; protein synthesis; small ribosomal subunit