title: Issues Affecting the Loco-regional and Systemic Management of Patients with Invasive Lobular Carcinoma of the Breast.
abstract: Invasive lobular carcinoma (ILC) of the breast is the second most common type of invasive breast carcinoma accounting for 8-14% of all breast cancers. Traditional management of ILC has followed similar paradigms as that for invasive ductal carcinoma (IDC). However, ILC represents a pathologically, clinically and biologically unique variant of breast cancer with particular management challenges. These challenges are seen in both the loco-regional management of ILC; where ILC tumors tend to avoid detection and hence present as more clinically advanced and surgically challenging carcinomas, and the systemic management with a unique response pattern to standard systemic therapies. Because of these challenges, the outcome for patients with ILC has likely lagged behind the continued improvements seen in outcome for patients with IDC. Here, we discuss some of the unique challenges ILC presents and discuss possible management strategies to best overcome the difficulties in the loco-regional and systemic management of patients with ILC.
authors.affiliation: Division of Medical Oncology, The Ottawa Hospital Cancer Center, Ottawa, Ontario, Canada.
authors.forename: Carmel
authors.initials: C
authors.lastname: Jacobs
authors.affiliation: Division of Medical Oncology, The Ottawa Hospital Cancer Center, Ottawa, Ontario, Canada.|Division of Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Clemons
authors.affiliation: Division of Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
authors.forename: Christina
authors.initials: C
authors.lastname: Addison
authors.affiliation: Department of Anatomical Pathology, Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: Susan
authors.initials: S
authors.lastname: Robertson
authors.affiliation: Division of Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.|Division of Surgical Oncology, Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: Angel
authors.initials: A
authors.lastname: Arnaout
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy*; D018275:Carcinoma, Lobular / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008408:Mastectomy; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D016896:Treatment Outcome
keywords: infiltrating ductal carcinoma; infiltrating lobular carcinoma; loco-regional management; systemic therapy