title: Click-Crosslinked Injectable Gelatin Hydrogels.
abstract: Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and biodegradation when injected in vivo.
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.|Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, 02139, USA.
authors.forename: Sandeep T
authors.initials: ST
authors.lastname: Koshy
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
authors.forename: Rajiv M
authors.initials: RM
authors.lastname: Desai
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|Julius Wolff Institute and Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, 13353, Germany.
authors.forename: Pascal
authors.initials: P
authors.lastname: Joly
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
authors.forename: Jianyu
authors.initials: J
authors.lastname: Li
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
authors.forename: Rishi K
authors.initials: RK
authors.lastname: Bagrodia
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Lewin
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
authors.forename: Neel S
authors.initials: NS
authors.lastname: Joshi
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Mooney
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002448:Cell Adhesion; D049109:Cell Proliferation; D048430:Cell Shape; D057930:Click Chemistry / Q000379:methods*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D005260:Female; D005780:Gelatin / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D051379:Mice; D040521:Subcutaneous Tissue
chemical_list: D003432:Cross-Linking Reagents; D020100:Hydrogels; D005780:Gelatin
keywords: click chemistry; degradable; gelatin; hydrogels; injectable