title: The Predictive Value of Pretreatment18-F-FDG-PET-CT in Locally Advanced Nasopharyngeal Cancer Patients Treated Definitively with Induction Chemotherapy Followed by Concurrent Chemo-Radiotherapy.
abstract: OBJECTIVE
  This study aimed to evaluate the role of pretreatment 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG-PET-CT) as a predictor of disease-free survival (DFS), and overall survival (OS) in locally advanced nasopharyngeal carcinoma (LANPC) patients treated definitively with docetaxel-based induction chemotherapy followed by concurrent chemoradiation (CRT).
  
  
  METHODS
  This is a retrospective study approved by the institutional review board and included LANC patients treated definitively and consecutively between January 2008 and December 2012 with induction chemotherapy; docetaxel, cisplatin, and 5-flurouracil (TPF) followed by CRT utilizing weekly cisplatin. All patients had baseline pretreatment18F-FDG-PET-CT. We studied the association between the baseline primary tumor maximum standardized uptake value (SUVmax) and the treatment outcomes; OS and DFS.
  
  
  RESULTS
  The study included 70 eligible LANPC patients. The 4-year OS and DFS rates were 86.7% and 78.6%, respectively. The median OS and DFS intervals were not reached. On a univariate analysis, the 4-years DFS was significantly higher in patients with pretreatment SUVmax <8 compared versus ≥ 8 (95% vs 57.7%, P=0.002). Furthermore, DFS was significantly correlated with pretreatment T stage (P=0.01), N stage (P=0.02), treatment response (P<0.001) and treatment breaks (P<0.001). On a multivariate analysis, the SUVmax category was the only factor correlated with 4-year DFS (Hazard ratio=10.2, 95% C I 1.3-116.8, P=0.035) but not OS (P=0.085).
  There is no actual or potential conflict of interest with the production and publication of this work. No author has a direct or indirect commercial financial incentive associated with the publication of this article.
  
  
  CONCLUSIONS
  This study shows that the pretreatment primary tumor18F-FDG-PET-CT SUVmax is a potential independent prognostic predictor of clinical outcomes in patients with LANC treated definitively with TPF induction chemotherapy followed by CRT. Further controlled clinical trials are worthwhile.
authors.affiliation: Department of Clinical Oncology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
authors.forename: Hala A
authors.initials: HA
authors.lastname: Zaghloul
authors.affiliation: Department of Clinical Oncology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
authors.forename: Gehan A
authors.initials: GA
authors.lastname: Khedr
authors.affiliation: Department of Clinical Oncology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
authors.forename: Yousri
authors.initials: Y
authors.lastname: Rostom
authors.affiliation: Department of Clinical Oncology, Faculty of Medicine, Alexandria University, Alexandria, Egypt ; Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
authors.forename: Tamer
authors.initials: T
authors.lastname: Refaat
keywords: 18F-FDG-PET-CT SUVmax; Concurrent chemoradiation; Nasopharyngeal cancer