title: Pulmonary mucosa-associated lymphoid tissue lymphoma revisited.
abstract: This general review sought to clarify the pathophysiological, diagnostic, prognostic, and therapeutic features of pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma.MALT lymphoma is the most common pulmonary B-cell lymphoma, which usually occurs in the context of acquired MALT. The disease is slow-growing with an asymptomatic chronic alveolar opacity visible on radiography. Diagnosis requires tissue samples that should be retrieved using minimally invasive techniques, such as bronchoscopy or computed tomography-guided biopsies. The pathophysiology includes cytogenetic abnormalities and autoimmune diseases, whereas an association with a chronic pulmonary infection is still suspected but not yet demonstrated. Disease prognosis is typically excellent and the current available treatments are discussed in this review, including the decision not to treat, surgery, and single- or double-agent chemotherapy.
authors.affiliation: Service de Pneumologie A, Centre de compétences maladies pulmonaires rares, AP-HP, Hôpital Bichat, Paris, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Borie
authors.affiliation: Service de Pneumologie, Centre de compétences maladies pulmonaires rares, AP-HP, Hôpital Tenon, Paris, France GRC-THERANOSCAN, Université P&M Curie, Université Paris 6, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Wislez
authors.affiliation: GRC-THERANOSCAN, Université P&M Curie, Université Paris 6, Paris, France Service d'Anatomie pathologique, AP-HP, Hôpital Tenon, Paris, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Antoine
authors.affiliation: AP-HP, Groupe Henri Mondor-Albert Chenevier, Département de Pathologie, Creteil, France.
authors.forename: Christiane
authors.initials: C
authors.lastname: Copie-Bergman
authors.affiliation: Service d'Hémato-oncologie, AP-HP, Hôpital Saint-Louis, Université Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Thieblemont
authors.affiliation: Service de Pneumologie, Centre de compétences maladies pulmonaires rares, AP-HP, Hôpital Tenon, Paris, France GRC-THERANOSCAN, Université P&M Curie, Université Paris 6, Paris, France jacques.cadranel@aphp.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Cadranel
mesh_terms: D000818:Animals; D001980:Bronchi / Q000473:pathology; D018893:Bronchoalveolar Lavage; D001999:Bronchoscopy; D003937:Diagnosis, Differential; D006801:Humans; D008168:Lung / Q000378:metabolism; D008221:Lymphoid Tissue / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D020545:Respiratory Mucosa / Q000378:metabolism*; D014057:Tomography, X-Ray Computed