title: Safety and efficacy of selective retina therapy (SRT) for the treatment of diabetic macular edema in Korean patients.
abstract: OBJECTIVE
  Selective retina therapy (SRT) stimulates retinal pigment epithelium (RPE) cell migration and proliferation into irradiated areas. The objective of this study was to evaluate the efficacy and safety of SRT in Korean patients with clinically significant diabetic macular edema (DME).
  
  
  METHODS
  Prospective non-randomized interventional case series study. Twenty-three eyes of 21 patients with clinically significant DME were treated with SRT and followed for 6 months. Patients underwent an evaluation of best corrected visual acuity (BCVA) in Early Treatment Diabetic Retinopathy Study (ETDRS) letters. Microperimetry was employed to measure macular sensitivity within the central 10° field, and the central macular thickness (CMT) and maximum macular thickness (MMT) were measured.
  
  
  RESULTS
  An improvement in BCVA of one to two ETDRS lines was observed in 41.2 % of patients and an improvement of greater than two lines in 29.4 %. Although there was no significant change in CMT (P > 0.05), MMT decreased from 465.8 ± 87.4 μm to 434.3 ± 83.9 μm (P = 0.006), and mean macular sensitivity increased from 20.8 ± 3.4dB to 22.5 ± 3.5dB (P = 0.02).
  
  
  CONCLUSIONS
  The gains in BCVA and improvement in macular sensitivity demonstrated that SRT may be used as an effective and safe treatment modality in Korean patients with clinically significant DME.
authors.affiliation: Department of Ophthalmology and Visual Science, Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Young Gun
authors.initials: YG
authors.lastname: Park
authors.affiliation: Department of Ophthalmology and Visual Science, Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jae Ryun
authors.initials: JR
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology and Visual Science, Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Seungbum
authors.initials: S
authors.lastname: Kang
authors.affiliation: Medical Laser Center Lübeck GmbH, Lübeck, Germany.
authors.forename: Eric
authors.initials: E
authors.lastname: Seifert
authors.affiliation: Medical Laser Center Lübeck GmbH, Lübeck, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Theisen-Kunde
authors.affiliation: Medical Laser Center Lübeck GmbH, Lübeck, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Brinkmann
authors.affiliation: Department of Ophthalmology and Visual Science, Catholic University of Korea, Seoul, Republic of Korea. youngjungroh@hanmail.net.|Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, No. 62 Yeouido-dong, Yeongdeungpo-gu, Seoul, 150-713, Republic of Korea. youngjungroh@hanmail.net.
authors.forename: Young-Jung
authors.initials: YJ
authors.lastname: Roh
mesh_terms: D000368:Aged; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D015994:Incidence; D053685:Laser Therapy / Q000379:methods*; D008269:Macular Edema / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D055213:Retinal Pigment Epithelium / Q000000981:diagnostic imaging*; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity
keywords: Diabetic macular edema; Dosimetry; Microperimetry; Retinal pigment epithelium; Selective retina therapy