title: Healthy aging: The ultimate preventative medicine.
abstract: Age is the greatest risk factor for nearly every major cause of mortality in developed nations. Despite this, most biomedical research focuses on individual disease processes without much consideration for the relationships between aging and disease. Recent discoveries in the field of geroscience, which aims to explain biological mechanisms of aging, have provided insights into molecular processes that underlie biological aging and, perhaps more importantly, potential interventions to delay aging and promote healthy longevity. Here we describe some of these advances, along with efforts to move geroscience from the bench to the clinic. We also propose that greater emphasis should be placed on research into basic aging processes, because interventions that slow aging will have a greater effect on quality of life compared with disease-specific approaches.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA 98195, USA. kaeber@uw.edu.
authors.forename: Matt
authors.initials: M
authors.lastname: Kaeberlein
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Rabinovitch
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA 98195, USA. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: George M
authors.initials: GM
authors.lastname: Martin
mesh_terms: D000375:Aging; D000818:Animals; D004032:Diet; D015444:Exercise; D005853:Geriatrics / Q000639:trends*; D006262:Health; D006801:Humans; D009026:Mortality; D011315:Preventive Medicine / Q000639:trends*; D012307:Risk Factors; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D057170:Translational Research, Biomedical / Q000639:trends
chemical_list: D058570:TOR Serine-Threonine Kinases