title: A review of chemical gradient systems for cell analysis.
abstract: Microfluidic spatial and temporal gradient generators have played an important role in many biological assays such as in the analysis of wound healing, inflammation, and cancer metastasis. Chemical gradient systems can also be applied to other fields such as drug design, chemical synthesis, chemotaxis, etc. Microfluidic systems are particularly amenable to gradient formation, as the length scales used in chips enable fluid processes that cannot be conducted in bulk scale. In this review we discuss new microfluidic devices for gradient generation and applications of those systems in cell analysis.
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
authors.forename: Himali
authors.initials: H
authors.lastname: Somaweera
authors.affiliation: Department of Mathematics and Statistics, Texas Tech University, Lubbock, TX 79409, USA.
authors.forename: Akif
authors.initials: A
authors.lastname: Ibraguimov
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA. Electronic address: d.pappas@ttu.edu.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Pappas
mesh_terms: D057446:Hydrodynamics; D056656:Lab-On-A-Chip Devices; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis
keywords: Gradient; Lab on a chip; Microfluidics; Review