title: Enterography CT without and with water enema in patients with Crohn's disease: Results from a comparative observational study in comparison with endoscopy.
abstract: OBJECTIVE
  CT is nowadays an examination routinely performed in Crohn's disease (CD) patients. However, there are several ways to assess gastro-intestinal tract, in particular colonic segments. Aim of this study is to compare enterography-CT (E-CT), performed after oral administration of polyethylene-glycol solution (PEG-CT) versus enterography-CT performed also with water enema via rectum (ECT-WE) in patients with CD.
  
  
  METHODS
  We have studied 79 patients with CD undergone to enterography-CT (42 evaluated with PEG-CT and 37 with ECT-WE) who have performed a lower endoscopy within 15 days before CT. CT results concerning large bowel were compared with endoscopic findings. Intestinal distension, discomfort of the patients, sensitivity, specificity and diagnostic accuracy were evaluated. Pearson test was used for statistical analysis.
  
  
  RESULTS
  Degree of abdominal pain was significantly higher in patients underwent to ECT-WE compared to PEG-CT. Distension of the colon was significantly greater in patients studied with ECT-WE compared to those studied with PEG-CT. Values of sensitivity, specificity and diagnostic accuracy of PEG-CT and ECT-WE were respectively 77, 86.5 and 81%, and 89, 100 and 92% in comparison with endoscopy.
  
  
  CONCLUSIONS
  In patients with CD, ECT-WE allows the evaluation of large bowel in addition to small bowel better than PEG-CT.
authors.affiliation: Catholic University of Sacred Heart, Department of Bio-Imaging and Radiological Sciences, Rome, Italy. Electronic address: lauraminordi@virgilio.it.
authors.forename: Laura Maria
authors.initials: LM
authors.lastname: Minordi
authors.affiliation: Catholic University of Sacred Heart, Department of Internal Medicine, Gastroenterology Division, Rome, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Scaldaferri
authors.affiliation: Catholic University of Sacred Heart, Department of Bio-Imaging and Radiological Sciences, Rome, Italy.
authors.forename: Rosa Speranza
authors.initials: RS
authors.lastname: Marra
authors.affiliation: Catholic University of Sacred Heart, Department of Internal Medicine, Gastroenterology Division, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Pecere
authors.affiliation: Catholic University of Sacred Heart, Department of Bio-Imaging and Radiological Sciences, Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Larosa
authors.affiliation: Catholic University of Sacred Heart, Institute of Hygiene, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Poscia
authors.affiliation: Catholic University of Sacred Heart, Department of Internal Medicine, Gastroenterology Division, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
authors.affiliation: Catholic University of Sacred Heart, Department of Bio-Imaging and Radiological Sciences, Rome, Italy.
authors.forename: Amorino
authors.initials: A
authors.lastname: Vecchioli
authors.affiliation: Catholic University of Sacred Heart, Department of Bio-Imaging and Radiological Sciences, Rome, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Bonomo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003106:Colon / Q000000981:diagnostic imaging; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004733:Enema; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014867:Water / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D014867:Water; D011092:Polyethylene Glycols
keywords: Colon; Endoscopy; Enema; Multidetector computed tomography; Polyethylene glycols