title: Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike.
abstract: Gastric carcinoma (GC) develops in only 1%-3% of Helicobacter pylori (H. pylori) infected people. The role in GC formation of the bacterial genotypes, gene polymorphisms and host's factors may therefore be important. The risk of GC is enhanced when individuals are infected by strains expressing the oncoprotein CagA, in particular if CagA has a high number of repeats containing the EPIYA sequence in its C'-terminal variable region or particular amino acid sequences flank the EPIYA motifs. H. pylori infection triggers an inflammatory response characterised by an increased secretion of some chemokines by immunocytes and colonised gastric epithelial cells; these molecules are especially constituted by proteins composing the interleukin-1beta (IL-1β) group and tumour necrosis factor-alpha (TNF-α). Polymorphisms in the promoter regions of genes encoding these molecules, could account for high concentrations of IL-1β and TNF-α in the gastric mucosa, which may cause hypochlorhydria and eventually GC. Inconsistent results have been attained with other haplotypes of inflammatory and anti-inflammatory cytokines. Genomic mechanisms of GC development are mainly based on chromosomal or microsatellite instability (MSI) and deregulation of signalling transduction pathways. H. pylori infection may induce DNA instability and breaks of double-strand DNA in gastric mucocytes. Different H. pylori strains seem to differently increase the risk of cancer development run by the host. Certain H. pylori genotypes (such as the cagA positive) induce high degrees of chronic inflammation and determine an increase of mutagenesis rate, oxidative-stress, mismatch repair mechanisms, down-regulation of base excision and genetic instability, as well as generation of reactive oxygen species that modulate apoptosis; these phenomena may end to trigger or concur to GC development.
authors.affiliation: Natale Figura, Department of Medical, Surgical and Neurological Sciences, University of Siena and Policlinico S. Maria alle Scotte, 53100 Siena, Italy.
authors.forename: Natale
authors.initials: N
authors.lastname: Figura
authors.affiliation: Natale Figura, Department of Medical, Surgical and Neurological Sciences, University of Siena and Policlinico S. Maria alle Scotte, 53100 Siena, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Marano
authors.affiliation: Natale Figura, Department of Medical, Surgical and Neurological Sciences, University of Siena and Policlinico S. Maria alle Scotte, 53100 Siena, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Moretti
authors.affiliation: Natale Figura, Department of Medical, Surgical and Neurological Sciences, University of Siena and Policlinico S. Maria alle Scotte, 53100 Siena, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ponzetto
keywords: CagA; CagA gene polymorphism; Gastric carcinoma; Gene methylation; Haplotype; Helicobacter pylori infection; Human gene mutation; Inflammatory cytokine