title: Atypical manifestations of Epstein-Barr virus in children: a diagnostic challenge.
abstract: OBJECTIVE
  Clarify the frequency and the pathophysiological mechanisms of the rare manifestations of Epstein-Barr virus infection.
  
  
  METHODS
  Original research studies published in English between 1985 and 2015 were selected through a computer-assisted literature search (PubMed and Scopus). Computer searches used combinations of key words relating to "EBV infections" and "atypical manifestation."
  
  
  RESULTS
  Epstein-Barr virus is a herpes virus responsible for a lifelong latent infection in almost every adult. The primary infection concerns mostly children and presents with the clinical syndrome of infectious mononucleosis. However, Epstein-Barr virus infection may exhibit numerous rare, atypical and threatening manifestations. It may cause secondary infections and various complications of the respiratory, cardiovascular, genitourinary, gastrointestinal, and nervous systems. Epstein-Barr virus also plays a significant role in pathogenesis of autoimmune diseases, allergies, and neoplasms, with Burkitt lymphoma as the main representative of the latter. The mechanisms of these manifestations are still unresolved. Therefore, the main suggestions are direct viral invasion and chronic immune response due to the reactivation of the latent state of the virus, or even various DNA mutations.
  
  
  CONCLUSIONS
  Physicians should be cautious about uncommon presentations of the viral infection and consider EBV as a causative agent when they encounter similar clinical pictures.
authors.affiliation: Child Health Department, University Hospital of Ioannina (UHI), Ioannina, Greece. Electronic address: v.bolis7@gmail.com.
authors.forename: Vasileios
authors.initials: V
authors.lastname: Bolis
authors.affiliation: Child Health Department, University Hospital of Ioannina (UHI), Ioannina, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Karadedos
authors.affiliation: Child Health Department, University Hospital of Ioannina (UHI), Ioannina, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Chiotis
authors.affiliation: Child Health Department, University Hospital of Ioannina (UHI), Ioannina, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Chaliasos
authors.affiliation: Child Health Department, University Hospital of Ioannina (UHI), Ioannina, Greece.
authors.forename: Sophia
authors.initials: S
authors.lastname: Tsabouri
mesh_terms: D000328:Adult; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007244:Infectious Mononucleosis / Q000821:virology*
keywords: Child; Complications; Complicações; Crianças; Epstein–Barr virus; Infectious mononucleosis; Mononucleose infecciosa; Vírus de Epstein–Barr