title: A Smart CMOS Assay SoC for Rapid Blood Screening Test of Risk Prediction.
abstract: A micro-controller unit (MCU) assisted immunoassay lab-on-a-chip is realized in 0.35 μm CMOS technology. The MCU automatically controls the detection procedure including blood filtration through a nonporous aluminum oxide membrane, bimolecular conjugation with antibodies attached to magnetic beads, electrolytic pumping, magnetic flushing and threshold detection based on Hall sensor array readout analysis. To verify the function of this chip, in-vitro Tumor necrosis factor- α (TNF-α) and N-terminal pro-brain natriuretic peptide (NT-proBNP) tests are performed by this 9 mm(2)-sized single chip. The cost, efficiency and portability are considerably improved compared to the prior art.
authors.forename: Po-Hung
authors.initials: PH
authors.lastname: Kuo
authors.forename: Jui-Chang
authors.initials: JC
authors.lastname: Kuo
authors.forename: Hsiao-Ting
authors.initials: HT
authors.lastname: Hsueh
authors.forename: Jian-Yu
authors.initials: JY
authors.lastname: Hsieh
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Huang
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Yen-Hung
authors.initials: YH
authors.lastname: Lin
authors.forename: Chih-Ting
authors.initials: CT
authors.lastname: Lin
authors.forename: Yao-Joe
authors.initials: YJ
authors.lastname: Yang
authors.forename: Shey-Shi
authors.initials: SS
authors.lastname: Lu
mesh_terms: D001774:Blood Chemical Analysis / Q000295:instrumentation*; D006801:Humans; D007118:Immunoassay; D056656:Lab-On-A-Chip Devices / Q000191:economics; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D019095:Point-of-Care Systems; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D010446:Peptide Fragments; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain