title: Relationship between rs1047763 polymorphism of the C1GALT1 gene and susceptibility to immunoglobulin A nephropathy in Xinjiang Uyghur people.
abstract: We explored the relationship between rs1047763, a single-nucleotide polymorphism (SNP) of the C1GALT1 gene, and genetic susceptibility to immunoglobulin A nephropathy (IgAN) in Xinjiang Uyghur people. The study comprised 90 patients with IgAN and 90 normal controls recruited from Uyghur people. The distribution of the rs1047763 polymorphism of C1GALT1 in each group was determined by direct sequencing analysis. The gene type, gene frequency, allele type, and allele frequency were calculated by direct counting and the genotype was investigated using the Hardy-Weinberg equilibrium test. The SPSS17.0 software was used for data processing, and genotype and allele frequencies were compared using the χ2 test. In the IgAN group, the AA, AG, and GG genotype frequencies in the rs1047763 polymorphism of the C1GALT1 gene were 21.10, 47.80, and 31.10%, respectively, while AA, AG, and GG genotype frequencies in the control group were 17.8, 40.0, and 42.2%, respectively. There was no statistically significant difference between the two groups (P > 0.05). The rs1047763 SNP of the C1GALT1 gene probably has no correlation with genetic susceptibility to IgAN in Xinjiang Uyghur people.
authors.affiliation: Nephrology Department, Tengzhou Central People's Hospital, Tengzhou, Shangdong, China.
authors.forename: J N
authors.initials: JN
authors.lastname: Xue
authors.affiliation: Nephrology Department, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Nephrology Department, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang, China.
authors.forename: X
authors.initials: X
authors.lastname: Song
authors.affiliation: Neurosurgery Department, Tengzhou Central People's Hospital, Tengzhou, Shangdong, China.
authors.forename: F
authors.initials: F
authors.lastname: Xue
authors.affiliation: Nephrology Department, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang, China.
authors.forename: S F
authors.initials: SF
authors.lastname: Yang
authors.affiliation: Nephrology Department, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang, China.
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Nephrology Department, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang, China.
authors.forename: R Z W A
authors.initials: RZ
authors.lastname: Bu-La
authors.affiliation: Nephrology Department, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang, China.
authors.forename: C
authors.initials: C
authors.lastname: Lu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005700:Galactosyltransferases / Q000235:genetics*; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: C505293:C1GALT1 protein, human; D005700:Galactosyltransferases