title: Epigenetic regulation in chondrocyte phenotype maintenance for cell-based cartilage repair.
abstract: Loss of hyaline chondrocyte phenotype during the monolayer culture in vitro is a major obstacle for cell-based articular cartilage repair. Increasing evidence implicates an important role of the epigenetic regulation in maintaining the chondrocyte phenotype. DNA methylation, histone modifications and microRNAs have all been shown to contribute to chondrocyte dedifferentiation and hypertrophy. Moreover, the interplay among epigenetic regulators forms a complicated epigenetic network in regulating chondrocyte dedifferentiation. This review provides a detailed overview of the epigenetic regulation in maintaining the chondrocyte phenotype for chondrocyte-based cartilage repair.
authors.affiliation: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's HospitalShenzhen 518035, Guangdong Province, China; Department of Orthopedics, Shenzhen Second People's HospitalShenzhen 518035, Guangdong Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Duan
authors.affiliation: School of Chemical Biology & Biotechnology, Peking University Shenzhen Graduate School Shenzhen 518000, Guangdong Province, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Division of Immunology, University Children's Hospital Zurich Zurich 8032, Switzerland.
authors.forename: Bin
authors.initials: B
authors.lastname: Ma
authors.affiliation: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's HospitalShenzhen 518035, Guangdong Province, China; Department of Orthopedics, Shenzhen Second People's HospitalShenzhen 518035, Guangdong Province, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's HospitalShenzhen 518035, Guangdong Province, China; Department of Orthopedics, Shenzhen Second People's HospitalShenzhen 518035, Guangdong Province, China.
authors.forename: Daping
authors.initials: D
authors.lastname: Wang
keywords: DNA methylation; cartilage repair; chondrocyte phenotype; histone acetylation; microRNAs