title: Heparin-induced thrombocytopenia in pregnancy: an interdisciplinary challenge-a case report and literature review.
abstract: Heparin-induced thrombocytopenia is a serious adverse event of anticoagulation with a high risk of thromboembolic complications. As a consequence, anticoagulants other than heparins must be administered. These may be unavailable, contraindicated during pregnancy, off-label, impractical due to short half-lives and, most importantly, may be unfamiliar to many anesthesiologists. Impaired coagulation bears the risk of adverse events following neuraxial procedures and of peripartum hemorrhage. We describe the case of heparin-induced thrombocytopenia in a 29-year-old pregnant woman at 27weeks of gestation with severe valvular heart disease.
authors.affiliation: Department for Anesthesia, Surgical Intensive Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Basel, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Mauermann
authors.affiliation: Department of Obstetrics, University Hospital Basel, Basel, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Vökt
authors.affiliation: Diagnostic Hematology, University Hospital Basel, Basel, Switzerland.
authors.forename: D A
authors.initials: DA
authors.lastname: Tsakiris
authors.affiliation: Department of Cardiology, University Hospital Basel, Basel, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Tobler
authors.affiliation: Department for Anesthesia, Surgical Intensive Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Basel, Switzerland. Electronic address: Thierry.Girard@usb.ch.
authors.forename: T
authors.initials: T
authors.lastname: Girard
mesh_terms: D000328:Adult; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000139:chemically induced*; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D006493:Heparin
keywords: Anticoagulation; Fondaparinux; Heparin-induced thrombocytopenia