title: Overlaying Molecular and Temporal Aspects of Malaria Parasite Invasion.
abstract: A highly-effective, long-lasting vaccine, targeting multiple stages of the Plasmodium falciparum life cycle, is likely to be important for the elimination of this pathogen. Key antigens of this vaccine would produce host antibodies that block the ligands required for merozoite invasion of erythrocytes, thereby curtailing the expansion of parasitemia and symptomatic disease. Recent live cell imaging of invading Plasmodium falciparum merozoites with various receptor-ligand interactions inhibited has provided new information about the function, sequence, and timing of these events, providing a rationale for a vaccine containing multiple antigens that inhibit the sequential steps of invasion.
authors.affiliation: Burnet Institute, Melbourne, VIC 3004, Australia; Monash University, Melbourne, VIC 3800, Australia.
authors.forename: Greta E
authors.initials: GE
authors.lastname: Weiss
authors.affiliation: Burnet Institute, Melbourne, VIC 3004, Australia; Monash University, Melbourne, VIC 3800, Australia; University of Melbourne, Melbourne, VIC 3010, Australia. Electronic address: crabb@burnet.edu.au.
authors.forename: Brendan S
authors.initials: BS
authors.lastname: Crabb
authors.affiliation: Burnet Institute, Melbourne, VIC 3004, Australia; Monash University, Melbourne, VIC 3800, Australia. Electronic address: gilson@burnet.edu.au.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Gilson
mesh_terms: D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D008018:Life Cycle Stages / Q000502:physiology; D008024:Ligands; D017780:Malaria Vaccines / Q000592:standards; D016778:Malaria, Falciparum / Q000503:physiopathology*; D010963:Plasmodium falciparum / Q000235:genetics / Q000502:physiology*; D015800:Protozoan Proteins / Q000235:genetics
chemical_list: D008024:Ligands; D017780:Malaria Vaccines; D015800:Protozoan Proteins
keywords: Plasmodium falciparum; erythrocyte; invasion; malaria; vaccine