title: [Impurity removal technology of Tongan injection in liquid preparation process].
abstract: In order to effectively remove the invalid impurities in Tongan injection, optimize the optimal parameters of the impurity removal technology of liquid mixing process, in this paper, taking Tongan injection as the research object, with the contents of celandine alkali, and sinomenine, solids reduction efficiency, and related substances inspection as the evaluation indexes, the removal of impurities and related substances by the combined process of refrigeration, coction and activated carbon adsorption were investigated, the feasibility of the impurity removal method was definited and the process parameters were optimized. The optimized process parameters were as follows: refrigerated for 36 h, boiled for 15 min, activated carbon dosage of 0.3%, temperature 100 degrees C, adsorption time 10 min. It can effectively remove the tannin, and other impurities, thus ensure the quality and safety of products.
authors.forename: Xu-fang
authors.initials: XF
authors.lastname: Yang
authors.forename: Xiu-hai
authors.initials: XH
authors.lastname: Wang
authors.forename: Wei-rong
authors.initials: WR
authors.lastname: Bai
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Kang
authors.forename: Jun-chao
authors.initials: JC
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D000327:Adsorption; D002606:Charcoal / Q000737:chemistry; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D004340:Drug Contamination / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D011786:Quality Control
chemical_list: D004365:Drugs, Chinese Herbal; C517866:fufang danshen; D002606:Charcoal