title: Thyroid Disease and the Heart.
abstract: Thyroid hormones have an intimate relationship with cardiac function. Some of the most significant clinical signs and symptoms of thyroid disease are the cardiac manifestations. In both hypothyroidism and hyperthyroidism, the characteristic physiological effects of thyroid hormone can be understood from the actions at the molecular and cellular level. Here we explore topics from the metabolism and cellular effects of thyroid hormone to special considerations related to statin and amiodarone therapy for the alterations in thyroid hormone metabolism that accompany heart disease.
authors.forename: Irwin
authors.initials: I
authors.lastname: Klein
authors.forename: Sara
authors.initials: S
authors.lastname: Danzi
mesh_terms: D000638:Amiodarone / Q000009:adverse effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D006331:Heart Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D012307:Risk Factors; D015398:Signal Transduction; D013959:Thyroid Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D013961:Thyroid Gland / Q000378:metabolism* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D000889:Anti-Arrhythmia Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D013963:Thyroid Hormones; D000638:Amiodarone