title: Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region.
abstract: The aim of the present study was to determine the prevalence of epidermal growth factor receptor mutations (EGFRmut) in the Gulf region (GR) and its correlation with demographic and clinical characteristics. A multisite retrospective study was conducted, including institutions from Saudi Arabia, the United Arab Emirates and Qatar. All consecutive patients with non-small-cell lung cancer tested for EGFRmut were eligible. Data collected included demographic information, disease characteristics and EGFR test results. Data on 230 patients were obtained. The median age of the patients was 61 years (range, 26-87 years); 169 patients (69.83%) were male and 204 (88.7%) were Arab. The histological subtype was adenocarcinoma in 191 (83.4%) and squamous cell carcinoma in 21 cases (9.17%). Overall, EGFRmut were detected in 66 patients (28.7%), with a prevalence of 32.46% in adenocarcinoma. No squamous cell carcinomas were found to harbor EGFRmut. The univariate and multivariate analyses revealed that female gender, non-smoking status and adenocarcinoma subtype were significant predictors for EGFRmut. There was no difference between Arabs and non-Arabs. In conclusion, to the best of our knowledge, this is the first multisite study to report the prevalence of EGFRmut in the GR population, which was found to be higher compared with that in Western, but lower compared with that in Far Eastern populations. Studies evaluating the efficacy of targeted therapy in this population are underway.
authors.affiliation: Department of Oncology, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh 11426, Kingdom of Saudi Arabia.
authors.forename: Abdul Rahman
authors.initials: AR
authors.lastname: Jazieh
authors.affiliation: Department of Oncology, Tawam Hospital, Al Ain 15258, United Arab Emirates.
authors.forename: Hasan
authors.initials: H
authors.lastname: Jaafar
authors.affiliation: Department of Oncology, Tawam Hospital, Al Ain 15258, United Arab Emirates.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Jaloudi
authors.affiliation: King Fahd Medical City, Riyadh 11525, Kingdom of Saudi Arabia.
authors.forename: Rasha Saleh
authors.initials: RS
authors.lastname: Mustafa
authors.affiliation: Department of Oncology, Al Amal Hospital, Doha 3050, Qatar.
authors.forename: Kakil
authors.initials: K
authors.lastname: Rasul
authors.affiliation: Department of Oncology King Faisal Specialist and Research Center, Riyadh 11211, Kingdom of Saudi Arabia.
authors.forename: Jamal
authors.initials: J
authors.lastname: Zekri
authors.affiliation: Department of Oncology, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh 11426, Kingdom of Saudi Arabia.
authors.forename: Hanaa
authors.initials: H
authors.lastname: Bamefleh
authors.affiliation: Department of Oncology, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh 11426, Kingdom of Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Gasmelseed
keywords: Gulf region; epidermal growth factor receptor; non-small-cell lung cancer