title: A population-based study on the association between chronic periodontitis and sialolithiasis.
abstract: OBJECTIVE
  Whereas the impression that poor oral hygiene is linked to the development of sialolithiasis may be widely accepted, very few studies provide evidence to support this. This study therefore aimed to evaluate the association between chronic periodontitis (CP) and the subsequent development of salivary gland stone based on a nationwide coverage database.
  
  
  METHODS
  A case-control study.
  
  
  METHODS
  A total of 987 subjects with sialolithiasis were included as cases. In a ratio of five controls per case, 4,935 controls matched in terms of sex and age group were selected. Conditional logistic regression analysis was performed to determine the possible association of sialolithiasis with previously diagnosed CP.
  
  
  RESULTS
  The prevalence of prior CP between cases and controls demonstrated that 1,831 (30.9%) out of the 5,922 sampled subjects had prior CP. By Chi-square test, there was a significant difference in the prevalence of prior CP between the cases and controls (36.8% vs. 29.7%, P < 0.001). By conditional logistic regression analysis, the odds ratio (OR) of prior CP for cases was 1.37 (95% confidence interval [CI], 1.19-1.56) compared to the controls after adjusting for geographic location and tobacco use. Further analyzing the relationship between sialolithiasis and prior CP according to sex, sialolithiasis was associated with prior CP regardless of sex. The adjusted OR of prior CP for the cases was 1.34 (95% CI, 1.10-1.64) and 1.41 (95% CI, 1.15-1.73) for males and females, respectively, when compared to controls.
  
  
  CONCLUSIONS
  This study demonstrates an association between CP and sialolithiasis.
  
  
  METHODS
  3b.
authors.affiliation: Department of Otolaryngology, Taipei, Taiwan.
authors.forename: Shih-Han
authors.initials: SH
authors.lastname: Hung
authors.affiliation: Sleep Research Center, Taipei, Taiwan.|Department of Otolaryngology, Taipei City Hospital, Taipei, Taiwan.
authors.forename: Hung-Meng
authors.initials: HM
authors.lastname: Huang
authors.affiliation: Sleep Research Center, Taipei, Taiwan.|Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Hsin-Chien
authors.initials: HC
authors.lastname: Lee
authors.affiliation: Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Herng
authors.initials: H
authors.lastname: Ching Lin
authors.affiliation: College of Science and Engineering, Fu-Jen Catholic University, Taipei, Taiwan.
authors.forename: Li-Ting
authors.initials: LT
authors.lastname: Kao
authors.affiliation: Graduate School of Business Administration, Fu-Jen Catholic University, Taipei, Taiwan.
authors.forename: Chuan-Song
authors.initials: CS
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015494:Salivary Gland Calculi / Q000209:etiology*; D055815:Young Adult
keywords: chronic periodontitis; epidemiology; sialolithiasis