title: Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis.
abstract: Numerous studies have evaluated the association between the A1166C polymorphism in the angiotensin II type 1 receptor (AGTR1) gene and immunoglobulin A nephropathy (IgAN) risk. However, this relationship remains controversial. Our aim was to evaluate the relationship between this polymorphism and IgAN susceptibility by performing a meta-analysis. Articles were identified in the PubMed, Google Scholar, and China National Knowledge Infrastructure databases, and after selection, five eligible studies were included. Statistical analyses were carried out using Stata 12.0, combining data from all the relevant studies. The pooled odds ratios (ORs) regarding the association between the AGTR1 A1166C polymorphism and IgAN risk were not statistically significant [A vs C: OR = 0.64, 95% confidence interval (CI) = 0.24-1.68; AA vs AC+CC: OR = 1.02, 95%CI = 0.74-1.39; CC vs AC+AA: OR = 1.20, 95%CI = 0.48-2.98; AC vs AA+CC: OR = 0.96, 95%CI = 0.70-1.31]. In conclusion, the AGTR1 gene A1166C polymorphism may not be correlated with IgAN susceptibility. However, further studies should be performed to confirm this finding.
authors.affiliation: Medical College of Shandong University, Jinan, Shandong Province, China.|Department of Nephrology, Dong E Hospital, Dong E, Shandong Province, China.
authors.forename: J M
authors.initials: JM
authors.lastname: Xu
authors.affiliation: Intensive Care Unit, Dong E Hospital, Dong E, Shandong Province, China.
authors.forename: X
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Pathology, Dong E Hospital, Dong E, Shandong Province, China.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
authors.forename: R
authors.initials: R
authors.lastname: Wang
mesh_terms: D044466:Asian People; D004198:Disease Susceptibility; D015870:Gene Expression; D056726:Genetic Association Studies; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012307:Risk Factors; D044465:White People
chemical_list: C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1