title: Impact of Oxygenation Status on 18F-FDG Uptake in Solid Tumors.
abstract: The influence of changes in tumor oxygenation (monitored by EPR oximetry) on the uptake of 18F-FDG tracer was evaluated using micro-PET in two different human tumor models. The 18F-FDG uptake was higher in hypoxic tumors compared to tumors that present a pO2 value larger than 10 mmHg.
authors.affiliation: Biomedical Magnetic Resonance Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Marie-Aline
authors.initials: MA
authors.lastname: Neveu
authors.affiliation: Radiation Oncology Department & Center for Molecular Imaging, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Vanesa
authors.initials: V
authors.lastname: Bol
authors.affiliation: Radiation Oncology Department & Center for Molecular Imaging, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Anne
authors.initials: A
authors.lastname: Bol
authors.affiliation: Radiation Oncology Department & Center for Molecular Imaging, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Grégoire
authors.affiliation: Biomedical Magnetic Resonance Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium. bernard.gallez@uclouvain.be.
authors.forename: Bernard
authors.initials: B
authors.lastname: Gallez
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004578:Electron Spin Resonance Spectroscopy; D019788:Fluorodeoxyglucose F18; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18; D010100:Oxygen
keywords: 18F-FDG; Carbogen; EPR; PET; Tumor oxygenation