title: Association Between Serum Uric Acid and Prevalence of Type 2 Diabetes Diagnosed using HbA1c Criteria Among Chinese Adults in Qingdao, China.
abstract: OBJECTIVE
  To determine whether elevated serum uric acid (UA) levels are associated with type 2 diabetes diagnosed using HbA1c levels among Chinese adults.
  
  
  METHODS
  We conducted two population-based cross-sectional studies in Qingdao in China in 2006 and 2009. A total of 6894 (39.4% men) subjects aged 35-74 years were included in the data analysis. Newly diagnosed diabetes was defined as HbA1c level of ⋝6.5%, and prediabetes was classified as HbA1c level between 5.7% and 6.4% according to the International Diabetes Federation criteria. Multivariate logistic regression was employed to assess the association between UA and prevalence of type 2 diabetes defined using Glycated hemoglobin A1c (HbA1c) levels.
  
  
  RESULTS
  Subjects with prediabetes had higher UA levels than those with normal glucose tolerance, newly diagnosed diabetes, and known diabetes, with corresponding values of 325.1 (82.5) µmol/L, 310.9 (84.2) µmol/L, 291.3 (81.7) µmol/L, 305.2 (83.6) µmol/L, respectively (P<0.001 for all comparisons). Binary logistic regression analysis showed that UA was a possible predictor for the prevalence of type 2 diabetes diagnosed using HbA1c levels, and the second quartile of UA levels had a higher odds ratio (OR: 4.088; 95% CI: 2.900-5.765) for HbA1c than the other quartiles after adjusting for age, body mass index, sex, marital status, education, income, alcohol consumption, smoking, and cardiometabolic parameters.
  
  
  CONCLUSIONS
  Serum UA is significantly associated with type 2 diabetes diagnosed using HbA1c levels, independent of other cardiometabolic parameters.
authors.affiliation: Department of Nutrition and Food Hygiene, Medical College of Qingdao University, Qingdao 260071, Shandong, China; Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors.forename: Bai
authors.initials: B
authors.lastname: Xue
authors.affiliation: School of Public Health, Jilin University, Changchun 130021, Jilin, China; Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Ji Bin
authors.initials: JB
authors.lastname: Tan
authors.affiliation: Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ning
authors.affiliation: Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors.forename: Jian Ping
authors.initials: JP
authors.lastname: Sun
authors.affiliation: Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors.forename: Ke Yi
authors.initials: KY
authors.lastname: Zhang
authors.affiliation: Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors.forename: Shao Jie
authors.initials: SJ
authors.lastname: Wang
authors.affiliation: Department of Nutrition and Food Hygiene, Medical College of Qingdao University, Qingdao 260071, Shandong, China.
authors.forename: Dong Feng
authors.initials: DF
authors.lastname: Zhang
authors.affiliation: Department of Public Health, University of Helsinki 00014, Finland.
authors.forename: Qing
authors.initials: Q
authors.lastname: Qiao
authors.affiliation: Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors.forename: Zeng Chang
authors.initials: ZC
authors.lastname: Pang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014527:Uric Acid / Q000097:blood*
chemical_list: D006442:Glycated Hemoglobin; D014527:Uric Acid
keywords: Cardiometabolic parameters; Hemoglobin A1c; Type 2 diabetes; Uric acid