title: Proving the suitability of magnetoelectric stimuli for tissue engineering applications.
abstract: A novel approach for tissue engineering applications based on the use of magnetoelectric materials is presented. This work proves that magnetoelectric Terfenol-D/poly(vinylidene fluoride-co-trifluoroethylene) composites are able to provide mechanical and electrical stimuli to MC3T3-E1 pre-osteoblast cells and that those stimuli can be remotely triggered by an applied magnetic field. Cell proliferation is enhanced up to ≈ 25% when cells are cultured under mechanical (up to 110 ppm) and electrical stimulation (up to 0.115 mV), showing that magnetoelectric cell stimulation is a novel and suitable approach for tissue engineering allowing magnetic, mechanical and electrical stimuli.
authors.affiliation: Centro/Departamento de Física, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Ribeiro
authors.affiliation: Centro/Departamento de Física, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal; Algoritmi Research Centre, Universidade do Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.
authors.forename: V
authors.initials: V
authors.lastname: Correia
authors.affiliation: Centro/Departamento de Física, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Martins
authors.affiliation: IBB e Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
authors.forename: F M
authors.initials: FM
authors.lastname: Gama
authors.affiliation: Centro/Departamento de Física, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal; BCMaterials, Parque Científico y Tecnológico de Bizkaia, 48160, Derio, Spain. Electronic address: lanceros@fisica.uminho.pt.
authors.forename: S
authors.initials: S
authors.lastname: Lanceros-Mendez
mesh_terms: D000497:Alloys / Q000737:chemistry; D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation; D004419:Dysprosium / Q000737:chemistry; D004558:Electric Stimulation; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D060526:Magnetic Fields; D008567:Membranes, Artificial; D051379:Mice; D008856:Microscopy, Fluorescence; D010006:Osteoblasts / Q000166:cytology*; D015203:Reproducibility of Results; D013725:Terbium / Q000737:chemistry; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D000497:Alloys; D006845:Hydrocarbons, Fluorinated; D008567:Membranes, Artificial; D014753:Vinyl Compounds; C522521:poly(vinylidenefluoride-trifluoroethylene); D013725:Terbium; D004419:Dysprosium; D007501:Iron
keywords: Bone tissue engineering; Cell proliferation; Magnetic stimulus; Magnetoelectric