title: Degradation and transformation of 17α-estradiol in water-sediment systems under controlled aerobic and anaerobic conditions.
abstract: One of the principal metabolites in cattle excreta following the administration of Synovex® ONE, which contains estradiol benzoate and trenbolone acetate, is 17α-estradiol. As part of the environmental assessment of the use of Synovex ONE, data were generated to characterize the fate of 17α-estradiol in the environment. Studies were conducted to determine the degradation and transformation of 17α-[14C]-estradiol in 2 representative water-sediment systems each under aerobic and anaerobic conditions. The same transformation products-estriol, 17β-estradiol, and estrone-were formed, principally in the sediment phase, under both conditions in both systems. From the production of these transformation products, the 50% disappearance time (DT50) values of estrone and 17β-estradiol were determined, along with the DT50 values of 17α-estradiol and the total drug (17α-estradiol + 17β-estradiol + estrone). The results indicate that 17 α-[14C]-estradiol was more persistent under anaerobic conditions than under aerobic conditions and that 17 α-[14C]-estradiol was less persistent than its transformation products. The DT50 values for the total system (aqueous and sediment phases) and for the total residues (17α-estradiol, 17β-estradiol, and estrone) were selected for use in modeling the environmental fate of estradiol benzoate. For aerobic degradation in the water-sediment system, the DT50 was 31.1 d, and it was 107.8 d for the anaerobic system. Environ Toxicol Chem 2017;36:621-629. © 2016 SETAC.
authors.affiliation: Zoetis, Kalamazoo, Michigan, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Robinson
authors.affiliation: Exponent, Washington, DC, USA.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Exponent, Cary, North Carolina, USA.
authors.forename: Jane P
authors.initials: JP
authors.lastname: Staveley
authors.affiliation: Phase II+, Kalamazoo, Michigan, USA.
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Smolenski
authors.affiliation: Pfizer, Worldwide R&D, PDM-Environmental Sciences, Groton, Connecticut, USA.
authors.forename: Jon
authors.initials: J
authors.lastname: Ericson
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D001673:Biodegradation, Environmental; D002417:Cattle; D004784:Environmental Monitoring / Q000379:methods*; D004958:Estradiol / Q000031:analogs & derivatives / Q000032:analysis* / Q000378:metabolism; D004970:Estrone / Q000032:analysis; D004997:Ethinyl Estradiol / Q000032:analysis / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D019015:Geologic Sediments / Q000737:chemistry*; D045483:Rivers / Q000737:chemistry*; D014204:Trenbolone Acetate / Q000032:analysis / Q000378:metabolism; D014481:United States; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D014874:Water Pollutants, Chemical; C074283:estradiol 3-benzoate; D004970:Estrone; D004997:Ethinyl Estradiol; D004958:Estradiol; D014204:Trenbolone Acetate
keywords: Estradiol; Estrogenic compound; Steroid transformation; Synovex® ONE; Veterinary medicine