title: ISAba1/blaOXA-23: A serious obstacle to controlling the spread and treatment of Acinetobacter baumannii strains.
abstract: This study demonstrated a direct correlation between Acinetobacter baumannii clusters carrying the ISAba1/blaOXA-23 gene and increased minimal inhibitory concentrations for carbapenems and greater clonal diversity. Our findings showed that clusters carrying ISAba1 are widely distributed in our hospital, further complicating the treatment and control of infections caused by A baumannii.
authors.affiliation: Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá, PR, Brazil.
authors.forename: Giselle Fukita
authors.initials: GF
authors.lastname: Viana
authors.affiliation: Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá, PR, Brazil.
authors.forename: Maisa Cristina Barreto
authors.initials: MC
authors.lastname: Zago
authors.affiliation: Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá, PR, Brazil.
authors.forename: Rafael Renato Brondani
authors.initials: RR
authors.lastname: Moreira
authors.affiliation: Hospital Universitário de Maringá, Universidade Estadual de Maringá, PR, Brazil.
authors.forename: Mirian Nicéa
authors.initials: MN
authors.lastname: Zarpellon
authors.affiliation: Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá, PR, Brazil.
authors.forename: Thatiany Cevallos
authors.initials: TC
authors.lastname: Menegucci
authors.affiliation: Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá, PR, Brazil.
authors.forename: Celso Luiz
authors.initials: CL
authors.lastname: Cardoso
authors.affiliation: Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá, PR, Brazil. Electronic address: mcbtognim@uem.br.
authors.forename: Maria Cristina Bronharo
authors.initials: MC
authors.lastname: Tognim
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000201:enzymology* / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D014644:Genetic Variation; D005838:Genotype; D006761:Hospitals; D006801:Humans; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C000599728:beta-lactamase OXA-23, Acinetobacter baumannii
keywords: Acinetobacter baumannii; bla(OXA-23) gene; carbapenems; insertion sequence; resistance