title: [Conversion Therapy of Initially Unresectable Rectal Cancer with Perforation via FOLFOX4 Chemotherapy].
abstract: We describe a case of perforated rectal cancer that became curatively resectable after FOLFOX4 chemotherapy. An 81- year-old woman was transferred to our hospital with a diagnosis of bowel perforation. She underwent emergency transverse colostomy, peritoneal lavage, and the insertion of indwelling drainage tubes, because the perforated rectal cancer was considered unresectable. After recuperation, she received chemotherapy consisting of FOLFOX4 and bevacizumab. Owing to a good response to the treatment after 4 months, rectal resection was achieved curatively. Wound dehiscence occurred as a postoperative complication. The patient chose not to receive adjuvant chemotherapy. Currently, she has been alive for more than 1 year 3 months after resection without recurrence.
authors.affiliation: Dept. of Surgery, Fukaya Red Cross Hospital.
authors.forename: Chizu
authors.initials: C
authors.lastname: Yamada
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Ishikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nitta
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Fujita
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Omoto
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kamata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000008:administration & dosage; D003125:Colostomy; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology / Q000601:surgery*; D002955:Leucovorin / Q000008:administration & dosage; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D000068258:Bevacizumab; D002955:Leucovorin; D005472:Fluorouracil