title: A systematic review of capnography for sedation.
abstract: We included six trials with 2524 participants. Capnography reduced hypoxaemic episodes, relative risk (95% CI) 0.71 (0.56-0.91), p = 0.02, but the quality of evidence was poor due to high risks of performance bias and detection bias and substantial statistical heterogeneity. The reduction in hypoxaemic episodes was statistically homogeneous in the subgroup of three trials of 1823 adults sedated for colonoscopy, relative risk (95% CI) 0.59 (0.48-0.73), p < 0.001, although the risks of performance and detection biases were high. There was no evidence that capnography affected other outcomes, including assisted ventilation, relative risk (95% CI) 0.58 (0.26-1.27), p = 0.17.
authors.affiliation: Queensland University Technology Institute of Health & Biomedical Innovation, Brisbane, Queensland, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Conway
authors.affiliation: Queensland University Technology, School of Nursing, Brisbane, Queensland, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Douglas
authors.affiliation: Coffs Harbour Health Campus, Rural Clinical School, University of New South Wales, Coffs Harbour, New South Wales, Australia.
authors.forename: J R
authors.initials: JR
authors.lastname: Sutherland
mesh_terms: D000758:Anesthesia / Q000379:methods*; D019296:Capnography / Q000379:methods*; D003113:Colonoscopy; D006801:Humans; D000860:Hypoxia / Q000517:prevention & control*; D015203:Reproducibility of Results; D012306:Risk