title: Retinoblastoma in the adolescent. Unusual clinical and histopathology findings.
abstract: METHODS
  A 17-year- old male with 2years history of an intraocular mass and progressive visual loss of the left eye. Spontaneous sclera rupture occurred during enucleation. Microscopic evaluation with H-E, PAS and immunohistochemistry (NSE, GAFP, SYN, CD99) revealed a small blue round cell malignant neoplasm with extensive necrosis and apoptosis. The optic nerve, ciliary body, choroid, anterior chamber, and sclera were infiltrated. SYN was positive and CD99 was negative in neoplastic cells, consistent with a poorly differentiated retinoblastoma.
  
  
  CONCLUSIONS
  Retinoblastoma is the most frequent primary intraocular malignant tumour in childhood, but occasionally older patients can be affected. Immunohistochemistry is mandatory in poorly differentiated retinoblastomas.
authors.affiliation: Asociación para Evitar la Ceguera en México, IAP, Hospital Dr. Luis Sánchez Bulnes, México. Electronic address: varitahernandez@hotmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Hernández-Ayuso
authors.affiliation: Asociación para Evitar la Ceguera en México, IAP, Hospital Dr. Luis Sánchez Bulnes, México.
authors.forename: D
authors.initials: D
authors.lastname: Ríos y Valles-Valles
authors.affiliation: Instituto Nacional de Ciencias Médicas y Nutrición Dr. Salvador Zubirán, México.
authors.forename: C
authors.initials: C
authors.lastname: Lome-Maldonado
authors.affiliation: Asociación para Evitar la Ceguera en México, IAP, Hospital Dr. Luis Sánchez Bulnes, México.
authors.forename: A
authors.initials: A
authors.lastname: Gómez-Leal
authors.affiliation: Departamento de Medicina Experimental, Hospital General de México Dr. Eduardo Liceaga, México.
authors.forename: H A
authors.initials: HA
authors.lastname: Rodríguez-Martínez
authors.affiliation: Asociación para Evitar la Ceguera en México, IAP, Hospital Dr. Luis Sánchez Bulnes, México.
authors.forename: A A
authors.initials: AA
authors.lastname: Rodríguez-Reyes
mesh_terms: D000293:Adolescent; D015353:Eye Enucleation; D006801:Humans; D008297:Male; D009900:Optic Nerve; D009915:Orbit; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D012175:Retinoblastoma / Q000175:diagnosis* / Q000601:surgery
keywords: CD99; Enucleación; Enucleation; Immunohistochemistry; Inmunohistoquímica; Retinoblastoma; Sinaptofisina; Synaptophysin