title: Clinical Decision Support Tools: The Evolution of a Revolution.
abstract: Dashboard systems for clinical decision support integrate data from multiple sources. These systems, the newest in a long line of dose calculators and other decision support tools, utilize Bayesian approaches to fully individualize dosing using information gathered through therapeutic drug monitoring. In the treatment of inflammatory bowel disease patients with infliximab, dashboards may reduce therapeutic failures and treatment costs. The history and future development of modern Bayesian dashboard systems is described.
authors.affiliation: Projections Research Inc., Phoenixville, Pennsylvania, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Mould
authors.affiliation: Inflammatory Bowel Disease Centre Academic Medical Centre 1105 AZ, Amsterdam, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: D'Haens
authors.affiliation: Projections Research Inc., Phoenixville, Pennsylvania, USA.|Australian Centre for Pharmacometrics and Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, South Australia, Australia.
authors.forename: R N
authors.initials: RN
authors.lastname: Upton
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D001499:Bayes Theorem; D020000:Decision Support Systems, Clinical / Q000639:trends*; D003661:Decision Support Techniques; D004059:Diffusion of Innovation; D054796:Drug Dosage Calculations; D016903:Drug Monitoring / Q000639:trends*; D057286:Electronic Health Records / Q000639:trends; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D000069285:Infliximab / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D010597:Pharmacogenetics / Q000639:trends*
chemical_list: D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; D000069285:Infliximab