title: Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China.
abstract: OBJECTIVE
  Dimethylarginine dimethylaminohydrolase enzymes (DDAH), which are encoded by the genes DDAH1 and DDAH2, play a fundamental role in maintaining endothelial function. We conducted a case-control study on a Chinese population that included three ethnic groups (Han, Kazakh and Uygur), to systemically investigate associations between variations in the genes DDAH1 and DDAH2 and hypertension.
  
  
  METHODS
  Experimental study at the Department of Internal Medicine and Genetic Diagnosis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
  
  
  METHODS
  This case-control study included 1,224 patients with hypertension and 967 healthy unrelated individuals as controls. DDAH1 -396 4N (GCGT) del>ins, rs3087894, rs805304 and rs9267551 were genotyped using the TaqMan 5' nuclease assay.
  
  
  RESULTS
  The G/C genotype of rs3087894 in DDAH1 was a risk factor for hypertension in the Kazakh group in the co-dominant model (G/C versus G/G) (OR 1.39; 95% CI: 1.02-1.88; P < 0.05), with the same result in the dominant model (G/C + C/C versus G/G) (OR 1.38; 95% CI: 1.03-1.84; P < 0.05). In contrast, the C/C genotype of rs3087894 seemed to be a protective factor against hypertension in the Uygur group in the recessive model (C/C versus G/G + G/C) (OR 0.62; 95% CI: 0.39- 0.97; P < 0.05). Similar findings for rs3087894 were also observed after adjusting the variable for the age covariate.
  
  
  CONCLUSIONS
  Our results indicated that the C-allele of rs3087894 in DDAH1 was a risk factor for hypertension in the Kazakh group but a protective factor in the Uygur group.
authors.affiliation: MD. Head of Department, Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: MD. Head of Department, Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, China. Doctoral Student, Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Shaoze
authors.initials: S
authors.lastname: Chen
authors.affiliation: MD. Doctoral Student, Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
authors.affiliation: MD. Head of Department, Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, China.
authors.forename: Guilin
authors.initials: G
authors.lastname: Lu
authors.affiliation: MD. Doctoral Student, Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Chengming
authors.initials: C
authors.lastname: Zhou
authors.affiliation: MD. Doctoral Student, Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Dao Wen
authors.initials: DW
authors.lastname: Wang
authors.affiliation: MD. Head of Department, Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: MD. Head of Department, Department of Cardiology, The People 's Hospital of Boertala, Bole, China.
authors.forename: Bayinbate
authors.initials: B
authors.lastname: Badengmu
authors.affiliation: MD. Head of Department, Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhai
authors.affiliation: MD. Head of Department, Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Qin
mesh_terms: D000328:Adult; D000368:Aged; D000581:Amidohydrolases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D000581:Amidohydrolases; C059999:dimethylargininase