title: [Effectiveness of Intraoperative Histologic Assessment of Surgical Margins for Breast-Conserving Surgery].
abstract: BACKGROUND
  The effectiveness of intraoperative histologic assessment of surgical margins for breast-conserving surgery is unclear. In this study, we investigated the effectiveness of intraoperative histologic assessment of surgical margins for breast-conserving surgery.
  
  
  METHODS
  Sixty-six patients who underwent breast-conserving surgery for breast cancer at our hospital between January 2007 and December 2013 were retrospectively examined for an association between the surgical margin status and locoregional recurrence. The surgical margins were then evaluated by intraoperative histologic assessment.
  
  
  RESULTS
  The median observation period was 52 months. Positive margins were found in 14 patients (21%). A total mastectomy was performed in 9 patients, and additional resection in 5 patients. In the permanent tissue sample, the intraoperative assessment was found to be false negative in 2 patients (3.8%), who received boost irradiation postoperatively. No locoregional recurrence was observed in all patients who underwent additional resection or total mastectomy due to positive margins. The rate of margin positivity was significantly higher in invasive lobular carcinomas and in cancers with intraductal extension.
  
  
  CONCLUSIONS
  Intraoperative histologic assessment of the surgical margin was useful for reducing the rate of local recurrence.
authors.affiliation: Dept. of Surgery, Fuchu Hospital.
authors.forename: Naoki
authors.initials: N
authors.lastname: Aomatsu
authors.forename: Seika
authors.initials: S
authors.lastname: Tei
authors.forename: Soichiro
authors.initials: S
authors.lastname: Hiramatsu
authors.forename: En
authors.initials: E
authors.lastname: Wang
authors.forename: Takehiko
authors.initials: T
authors.lastname: Iwauchi
authors.forename: Junya
authors.initials: J
authors.lastname: Morimoto
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nishii
authors.forename: Kinshi
authors.initials: K
authors.lastname: Kosaka
authors.forename: Yasutake
authors.initials: Y
authors.lastname: Uchima
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takeuchi
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental; D008875:Middle Aged; D012189:Retrospective Studies