title: А new Gal/GalNAc-specific lectin from the mussel Mytilus trossulus: Structure, tissue specificity, antimicrobial and antifungal activity.
abstract: In the present study, a new Gal/GalNAc specific lectin from the mussel Mytilus trossulus (designated as MTL) was identified, and its expression levels, both in tissues and toward pathogen stimulation, were then characterized. The MTL primary structure was determined via cDNA sequencing. Deduced sequence of 150 amino acid residues showed 89% similarity to lectins from the mussels Crenomytilus grayanus and Mytilus galloprovincialis that were the first members of a new family of zoolectins. The results indicated that the MTL might be involved in immune response toward pathogen infection, and it might perform different recognition specificity toward bacteria or fungi.
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159, Prospect 100 let Vladivostoku, Vladivostok 690022, Russia; Far Eastern Federal University, 8, Sukhanova Str., Vladivostok 690950, Russia. Electronic address: ivchik6@mail.ru.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Chikalovets
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159, Prospect 100 let Vladivostoku, Vladivostok 690022, Russia.
authors.forename: Svetlana N
authors.initials: SN
authors.lastname: Kovalchuk
authors.affiliation: Far Eastern Federal University, 8, Sukhanova Str., Vladivostok 690950, Russia.
authors.forename: Alina P
authors.initials: AP
authors.lastname: Litovchenko
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159, Prospect 100 let Vladivostoku, Vladivostok 690022, Russia.
authors.forename: Valentina I
authors.initials: VI
authors.lastname: Molchanova
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159, Prospect 100 let Vladivostoku, Vladivostok 690022, Russia.
authors.forename: Mikhail V
authors.initials: MV
authors.lastname: Pivkin
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159, Prospect 100 let Vladivostoku, Vladivostok 690022, Russia.
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Chernikov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism*; D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism*; D005658:Fungi / Q000502:physiology; D037102:Lectins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D049878:Mytilus / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology; D009928:Organ Specificity; D017433:Protein Structure, Secondary; D016415:Sequence Alignment; D014733:Vibrio / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D037102:Lectins
keywords: Amino acid sequence; Antifungal and antibacterial activity; GalNAc/Gal-specific lectin; Innate immunity; Mollusc; Mytilus trossulus