title: Chemical composition, in vitro antioxidant activity and α-glucosidase inhibitory effects of the essential oil and methanolic extract of Elsholtzia densa Benth.
abstract: Elsholtzia densa Benth. is a traditional aromatic herb used in the pharmaceutical and flavouring industries. To analyse and compare the chemical composition, the oils and nonvolatile compounds in E. densa and Mosla chinensis Maxim. were extracted via hydrodistillation, solvent extraction or ultrasound-assisted extraction. Seventy-three volatile compounds in the volatile oil (0.35 ± 0.06%) obtained by E. densa via hydrodistillation were investigated by gas chromatography-mass spectrometer and compared based on different parameters. Also, the antioxidant activity and α-glucosidase inhibitory effects of the five sub-fractions of the methanolic extract were studied and the ethyl acetate sub-fraction (EC50= 7.9 μg/mL) and petroleum ether sub-fraction (EC50= 0.0955 mg/mL) showed the strongest activity, respectively. This study has provided a scientific basis for scientific collection, effective development, use of E. densa Benth., and suggested that it can be used as a potential source of antioxidants in food and a potential candidate for the management of type 2 diabetes mellitus.
authors.affiliation: a School of Pharmacy , Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Xuanji
authors.affiliation: a School of Pharmacy , Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Guo
authors.initials: G
authors.lastname: Zengjun
authors.affiliation: a School of Pharmacy , Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Hui
authors.affiliation: a School of Pharmacy , Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Liu
authors.initials: L
authors.lastname: Xia
authors.affiliation: a School of Pharmacy , Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Luo
authors.initials: L
authors.lastname: Jun
authors.affiliation: a School of Pharmacy , Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Dandan
authors.affiliation: a School of Pharmacy , Xi'an Jiaotong University , Xi'an , P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Jun
keywords:  Benth.; antioxidant activity; comparisons of the chemical composition; α-glucosidase inhibitory effects