title: Successful Treatment with Modified FOLFOX6 and Panitumumab in a Cecal Cancer Patient Undergoing Hemodialysis.
abstract: Combination chemotherapy of mFOLFOX6 (5-fluorouracil, leucovorin, and oxaliplatin) plus panitumumab, a fully human monoclonal antibody against epidermal growth factor receptor (EGFR), is one of the standard treatments for metastatic colorectal cancer (mCRC) without KRAS mutation. A few reports suggested no need of dose adjustment of cetuximab, a similar chimeric anti-EGFR antibody, in patients with renal impairment. However, panitumumab combined with cytotoxic drugs for hemodialysis patients has not been reported. We herein report a case of a hemodialysis mCRC patient successfully treated with mFOLFOX6 and panitumumab combination therapy.
authors.affiliation: Division of Gastroenterology, University of Tsukuba Hospital, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Shinji
authors.initials: S
authors.lastname: Endo
authors.forename: Yukako
authors.initials: Y
authors.lastname: Hamano
authors.forename: Mamiko
authors.initials: M
authors.lastname: Imanishi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Akutsu
authors.forename: Akinori
authors.initials: A
authors.lastname: Sugaya
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ochi
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Moriwaki
authors.forename: Ichinosuke
authors.initials: I
authors.lastname: Hyodo
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002430:Cecal Neoplasms / Q000188:drug therapy*; D002432:Cecum / Q000473:pathology; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D000077544:Panitumumab; D006435:Renal Dialysis
chemical_list: D000911:Antibodies, Monoclonal; D009944:Organoplatinum Compounds; D000077544:Panitumumab; C512478:EGFR protein, human; D066246:ErbB Receptors; D002955:Leucovorin; D005472:Fluorouracil