title: The Role of Ezetimibe in the Treatment of Cardiovascular Disease.
abstract: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Despite the success of treatment of CVD with statin therapy, a number of patients remain at high risk for CVD. Ezetimibe is a non-statin agent that inhibits intestinal cholesterol absorption, leading to reductions in low-density lipoprotein cholesterol (LDL-C). A number of clinical studies evaluating the use of ezetimibe therapy have resulted in discordant data regarding its safety and efficacy. In this review, we discuss the findings from these studies as well as potential indications for the use of ezetimibe for LDL-C lowering and cardiovascular event reduction.
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, TX, 77030, USA. anandita.kulkarni@bcm.edu.
authors.forename: Anandita
authors.initials: A
authors.lastname: Agarwala
authors.affiliation: Columbia University, New York, NY, 10027, USA. zaid.kajani@columbia.edu.
authors.forename: Zaid
authors.initials: Z
authors.lastname: Kajani
authors.affiliation: Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minneapolis, MN, 55407, USA. mdm307@mail.harvard.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Miedema
authors.affiliation: Health Services Research and Development, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX, 77030, USA. virani@bcm.edu.|Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX, 77030, USA. virani@bcm.edu.|Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston, TX, 77030, USA. virani@bcm.edu.
authors.forename: Salim S
authors.initials: SS
authors.lastname: Virani
mesh_terms: D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D008078:Cholesterol, LDL / Q000032:analysis; D002986:Clinical Trials as Topic; D000069438:Ezetimibe / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D000069438:Ezetimibe
keywords: Cardiovascular disease; Ezetimibe; Low-density lipoprotein cholesterol