title: Hybrid models of cell and tissue dynamics in tumor growth.
abstract: Hybrid models of tumor growth, in which some regions are described at the cell level and others at the continuum level, provide a flexible description that allows alterations of cell-level properties and detailed descriptions of the interaction with the tumor environment, yet retain the computational advantages of continuum models where appropriate. We review aspects of the general approach and discuss applications to breast cancer and glioblastoma.
authors.affiliation: Department of Mathematics, Konkuk University, Seoul, South Korea. email:ahyouhappy@konkuk.ac.kr.
authors.forename: Yangjin
authors.initials: Y
authors.lastname: Kim
authors.forename: Hans G
authors.initials: HG
authors.lastname: Othmer
mesh_terms: D001696:Biomechanical Phenomena; D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology; D002465:Cell Movement; D049109:Cell Proliferation; D003198:Computer Simulation; D005260:Female; D005909:Glioblastoma / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D055641:Mathematical Concepts; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology; D015398:Signal Transduction; D059016:Tumor Microenvironment