title: Anti-Müllerian hormone in breast cancer patients treated with chemotherapy: a retrospective evaluation of subsequent pregnancies.
abstract: Few studies have reported reproductive outcomes after breast cancer chemotherapy. The relationship between anti-Müllerian hormone (AMH) concentrations and the occurrence of subsequent pregnancies in women after chemotherapy for breast cancer was investigated. Women aged 18-43 years treated with chemotherapy for invasive breast cancer between May 2005 and January 2011 were retrospectively identified. Exclusion criteria were previous gonadotoxic treatment, oophorectomy or hysterectomy. Measurement of AMH took place before, during chemotherapy and at distant time points after the end of chemotherapy (4 months to 5.5 years). Seventeen out of 134 patients experienced 28 spontaneous pregnancies (median follow-up: 59 months). Neither baseline AMH (divided into quartiles) nor end-of-chemotherapy AMH (detectable versus undetectable) were significantly associated with the occurrence of pregnancy. Chemotherapy regimen with anthracyclines was associated with a greater probability of pregnancy compared with a taxane-containing regimen (hazard ratio 4.75; (95% CI 1.76 to 12.8); P = 0.002). Five-year disease-free survival and overall survival rates were 60% (95% CI: 51 to 70; relapse, n = 48) and 88% (95% CI 82 to 95; deaths, n = 21), respectively. AMH did not predict the occurrence of pregnancy. Additional studies assessing ovarian reserve and reproductive outcomes after breast cancer are required.
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France. Electronic address: hamyannesophie@gmail.com.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Hamy
authors.affiliation: Hôtel Dieu, APHP, Centre d'épidémiologie, 75004 Paris, France; Inserm 75475 Paris Cedex 10, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Porcher
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Eskenazi
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Cuvier
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Giacchetti
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Coussy
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Hamid
authors.initials: H
authors.lastname: Hocini
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Tournant
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Francine
authors.initials: F
authors.lastname: Perret
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bonfils
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Charvériat
authors.affiliation: Service de Biochimie Endocrinienne et Oncologique, UF de Nutrigénétique, Groupe Hospitalier Pitié Salpêtrière, AP-HP, 47-83 Bd de l'Hôpital, 75651 Paris Cedex 13, France; U872 INSERM Equipe 4, Différenciation Intestinale et Métabolisme Lipidique, 15 Rue de l'Ecole de Médecine 75006 Paris, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Lacorte
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Espie
mesh_terms: D000293:Adolescent; D000328:Adult; D018943:Anthracyclines / Q000009:adverse effects / Q000627:therapeutic use; D054304:Anti-Mullerian Hormone / Q000097:blood*; D001943:Breast Neoplasms / Q000188:drug therapy*; D001952:Bridged-Ring Compounds / Q000009:adverse effects / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016019:Survival Analysis; D043823:Taxoids / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D018943:Anthracyclines; D001952:Bridged-Ring Compounds; D043823:Taxoids; C080625:taxane; D054304:Anti-Mullerian Hormone
keywords: anti-Müllerian hormone; breast cancer; chemotherapy; pregnancy