title: [A Case of Successful Treatment of Metachronous Liver Metastasis from Gastric Cancer with Hepatectomy].
abstract: A 77-year-old man was found to have advanced gastric cancer and underwent total gastrectomy (pT4aN2H0P0M0, Stage ⅢB). Two years after gastrectomy, we found an elevated tumor marker level, and a liver metastasis appeared in segment 5 (20 mm in diameter). He was treated with S-1/CDDP combination chemotherapy. After 2 courses of chemotherapy, the tumor marker level kept rising and a CT scan detected a progressive tumor. S-1/irinotecan combination chemotherapy was administered as second-line chemotherapy. After 6 courses of chemotherapy, the size of the liver metastasis was reduced and the tumor marker level normalized. Because lymph node metastasis or peritoneal recurrence was observed, a partial resection of the liver (S5) was performed. After the operation, he was treated with S-1 chemotherapy again for 1 year and has had no recurrence.
authors.affiliation: Dept. of Surgery, Nishinomiya Municipal Central Hospital.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Okada
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Oka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miyake
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakane
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Ueshima
authors.forename: Naozumi
authors.initials: N
authors.lastname: Higaki
authors.forename: Hirohito
authors.initials: H
authors.lastname: Hayashida
authors.forename: Riichiro
authors.initials: R
authors.lastname: Nezu
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D005743:Gastrectomy; D006498:Hepatectomy; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin