title: New marine natural products from sponges (Porifera) of the order Dictyoceratida (2001 to 2012); a promising source for drug discovery, exploration and future prospects.
abstract: The discovery of new drugs can no longer rely primarily on terrestrial resources, as they have been heavily exploited for over a century. During the last few decades marine sources, particularly sponges, have proven to be a most promising source of new natural products for drug discovery. This review considers the order Dictyoceratida in the Phylum Porifera from which the largest number of new marine natural products have been reported over the period 2001-2012. This paper examines all the sponges from the order Dictyoceratida that were reported as new compounds during the time period in a comprehensive manner. The distinctive physical characteristics and the geographical distribution of the different families are presented. The wide structural diversity of the compounds produced and the variety of biological activities they exhibited is highlighted. As a representative of sponges, insights into this order and avenues for future effective natural product discovery are presented. The research institutions associated with the various studies are also highlighted with the aim of facilitating collaborative relationships, as well as to acknowledge the major international contributors to the discovery of novel sponge metabolites. The order Dictyoceratida is a valuable source of novel chemical structures which will continue to contribute to a new era of drug discovery.
authors.affiliation: Centre for Marine Bioproducts Development, Flinders University, Adelaide, SA 5042, Australia; Department of Medical Biotechnology, School of Medicine, Flinders University, Adelaide, SA 5042, Australia; Department of Fisheries Technology, Hajee Mohammad Danesh Science & Technology University, Dinajpur 5200, Bangladesh.
authors.forename: Mohammad F
authors.initials: MF
authors.lastname: Mehbub
authors.affiliation: School of Chemical and Physical Sciences, Flinders University, Adelaide, SA 5042, Australia.
authors.forename: Michael V
authors.initials: MV
authors.lastname: Perkins
authors.affiliation: Centre for Marine Bioproducts Development, Flinders University, Adelaide, SA 5042, Australia; Department of Medical Biotechnology, School of Medicine, Flinders University, Adelaide, SA 5042, Australia.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Centre for Marine Bioproducts Development, Flinders University, Adelaide, SA 5042, Australia; Department of Medical Biotechnology, School of Medicine, Flinders University, Adelaide, SA 5042, Australia.
authors.forename: Christopher M M
authors.initials: CMM
authors.lastname: Franco
mesh_terms: D000818:Animals; D001688:Biological Products; D055808:Drug Discovery; D011161:Porifera
chemical_list: D001688:Biological Products
keywords: Dictyoceratida; Marine natural products; Novel chemical structures; Sponges (Porifera)