title: Effect of Nisin's Controlled Release on Microbial Growth as Modeled for Micrococcus luteus.
abstract: The need for safe food products has motivated food scientists and industry to find novel technologies for antimicrobial delivery for improving food safety and quality. Controlled release packaging is a novel technology that uses the package to deliver antimicrobials in a controlled manner and sustain antimicrobial stress on the targeted microorganism over the required shelf life. This work studied the effect of controlled release of nisin to inhibit growth of Micrococcus luteus (a model microorganism) using a computerized syringe pump system to mimic the release of nisin from packaging films which was characterized by an initially fast rate and a slower rate as time progressed. The results show that controlled release of nisin was strikingly more effective than instantly added ("formulated") nisin. While instant addition experiments achieved microbial inhibition only at the beginning, controlled release experiments achieved complete microbial inhibition for a longer time, even when as little as 15% of the amount of nisin was used as compared to instant addition.
authors.affiliation: Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ, 08901, USA.
authors.forename: Aishwarya
authors.initials: A
authors.lastname: Balasubramanian
authors.affiliation: Department of Food Science and Biotechnology, Kyungnam University, 449 Woryeong-dong, Masanhapo-gu, Changwon, 631-701, Korea.
authors.forename: Dong Sun
authors.initials: DS
authors.lastname: Lee
authors.affiliation: Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ, 08901, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Chikindas
authors.affiliation: Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ, 08901, USA. yam@aesop.rutgers.edu.
authors.forename: Kit L
authors.initials: KL
authors.lastname: Yam
keywords: Controlled release; Microbial kinetics; Micrococcus luteus; Nisin