title: The first cases of human bacteremia caused by Acinetobacter seifertii in Japan.
abstract: Acinetobacter seifertii, a novel species of Acinetobacter, was first reported in 2015. A. seifertii strains were isolated from human clinical specimens (blood, respiratory tract, and ulcer) and hospital environments. Here, we report the first cases of bacteremia caused by A. seifertii in patients with catheter-related bloodstream infection in Japan. The patients favorably recovered, without any complications, after removal of the peripheral intravenous catheters and administration of antibiotics. The pathogens were initially identified as Acinetobacter baumannii, using phenotypic methods and the MicroScan Walkaway System; however, rpoB gene sequence analysis indicated 99.54% similarity to A. seifertii. Moreover, antimicrobial susceptibility testing revealed that one of the strains was not susceptible to gentamicin and ceftazidime. Our report shows that Acinetobacter species other than A. baumannii can also cause nosocomial infections and that accurate methods for the identification of causative agents should be developed.
authors.affiliation: Department of Medical Technology, School of Health Sciences, Tokyo University of Technology, Nishikamata, Ohta-ku, Tokyo 144-8535, Japan; Department of Infectious Disease, Tokyo Women's Medical University, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address: kishiikze@stf.teu.ac.jp.
authors.forename: Kozue
authors.initials: K
authors.lastname: Kishii
authors.affiliation: Department of Infectious Disease, Tokyo Women's Medical University, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Kikuchi
authors.affiliation: Department of Microbiology, School of Pharmacy, Aichi Gakuin University, Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Tomida
authors.affiliation: Department of Microbiology, School of Pharmacy, Aichi Gakuin University, Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kawamura
authors.affiliation: Division of Infection Control, Dokkyo Medical University Hospital, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Division of Infection Control, Dokkyo Medical University Hospital, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Katsuko
authors.initials: K
authors.lastname: Okuzumi
authors.affiliation: Department of Infection Control and Prevention, University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Kyoji
authors.initials: K
authors.lastname: Moriya
mesh_terms: D000150:Acinetobacter; D000151:Acinetobacter Infections; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia; D055499:Catheter-Related Infections; D003428:Cross Infection; D006801:Humans; D007564:Japan; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents
keywords: Acinetobacter seifertii; Bacteremia; Catheter-related bloodstream infection; rpoB gene sequence analysis