title: Infection with human T-lymphotropic virus types-1 and -2 (HTLV-1 and -2): Implications for blood transfusion safety.
abstract: Many countries currently perform antibody screening for HTLV-1 infection in blood donors, and this intervention is likely cost-effective in preventing HTLV-1 related diseases in high prevalence countries. However, a number of high-income countries with low prevalence of HTLV-1 infection also perform universal HTLV-1 screening and debate has arisen regarding the cost-effectiveness of these strategies. Filter-based leukoreduction is likely to substantially reduce HTLV-1 transmission by removing infected lymphocytes, but actual laboratory data on its efficacy is currently lacking. Similarly, cost-effectiveness research on HTLV-1 prevention strategies is limited by poor data on prevalence, transmission efficacy and the cost of treating HTLV1 diseases.
authors.affiliation: Laboratory Medicine and Epidemiology/Biostatistics, University of California San Francisco and Senior investigator, Blood Systems Research Institute, San Francisco, USA. Electronic address: murphy@ucsf.edu.
authors.forename: E L
authors.initials: EL
authors.lastname: Murphy
mesh_terms: D001782:Blood Donors; D058731:Blood Safety; D001803:Blood Transfusion / Q000592:standards; D003362:Cost-Benefit Analysis; D046148:Donor Selection / Q000191:economics / Q000592:standards; D005544:Forecasting; D014943:Global Health; D015490:HTLV-I Infections / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D015491:HTLV-II Infections / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D015367:Human T-lymphotropic virus 2 / Q000302:isolation & purification*; D006801:Humans; D047589:Leukocyte Reduction Procedures; D008214:Lymphocytes / Q000821:virology; D015995:Prevalence; D000069078:Seroconversion; D065227:Transfusion Reaction; D014766:Viremia / Q000175:diagnosis* / Q000453:epidemiology / Q000635:transmission
keywords: Blood transfusion; Dépistage immunologique; HTLV-1; Immunoassay; Prevention and control; Prévention et contrôle; Transfusion sanguine