title: Association of waist circumference with impaired six-minute walk in type 2 diabetes mellitus is independent of cardiac function.
abstract: Subclinical left ventricular dysfunction has been associated with impaired exercise capacity in type 2 diabetes mellitus. In this community-based study of 274 asymptomatic T2DM patients (71±4 years, 55% men) with preserved ejection fraction, a comprehensive resting echocardiogram was performed to gather sensitive systolic and diastolic function parameters (including speckle tracking echocardiography), and a standard six-minute walk test was performed. Tertiles of increasing waist circumference were associated with worsening walk distance. In this community-based study, we found an association of waist circumference with impaired exercise capacity, independent of age, gender, diabetes duration, insulin and angiotensin blockade, LV mass, systolic and diastolic function.
authors.affiliation: Menzies Institute for Medical Research, Hobart, TAS, Australia.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Menzies Institute for Medical Research, Hobart, TAS, Australia.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Menzies Institute for Medical Research, Hobart, TAS, Australia.
authors.forename: Mark
authors.initials: M
authors.lastname: Nolan
authors.affiliation: Menzies Institute for Medical Research, Hobart, TAS, Australia.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Negishi
authors.affiliation: Royal Hobart Hospital, Hobart, TAS, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Burgess
authors.affiliation: Menzies Institute for Medical Research, Hobart, TAS, Australia. Electronic address: Tom.Marwick@utas.edu.au.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Marwick
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology*; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D051346:Mobility Limitation; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*; D055105:Waist Circumference / Q000502:physiology*; D016138:Walking / Q000502:physiology*
keywords: Diabetes; Exercise capacity; Left ventricular dysfunction; Six-minute walk test; Waist circumference