title: A New Bioactive Metabolite Isolated from the Red Sea Marine Sponge Hyrtios erectus.
abstract: Chemical investigation of the lipophilic fraction of Hyrtios erectus, a Red Sea sponge, yielded a new pentacyclic nitrogen-containing scalarane; 24-methoxypetrosaspongia C (1), together with the previously reported scalaranes sesterstatin 3 (2), 12-deacetyl-12-epi-scalaradial (3) and 12-deacetyl-12,18-di-epi-scalaradial (4). The compounds were identified using HRESIMS, 1D and 2D NMR experiments. The isolated compounds showed growth inhibitory activity against hepatocellular carcinoma (HepG2), colorectal carcinoma (HCT-116) and breast adenocarcinoma cells (MCF-7).
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. ssahmed@kau.edu.sa.|Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. ssahmed@kau.edu.sa.
authors.forename: Sameh S
authors.initials: SS
authors.lastname: Elhady
authors.affiliation: Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. ahalawany2003@yahoo.com.|Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el-Aini Street, Cairo 11562, Egypt. ahalawany2003@yahoo.com.
authors.forename: Ali M
authors.initials: AM
authors.lastname: El-Halawany
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. aalahdal2@hotmail.com.
authors.forename: Abdulrahman M
authors.initials: AM
authors.lastname: Alahdal
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. hashem_omar@pharm.suez.edu.eg.
authors.forename: Hashim A
authors.initials: HA
authors.lastname: Hassanean
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. safwat_aa@yahoo.com.
authors.forename: Safwat A
authors.initials: SA
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D019156:Indian Ocean; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D011161:Porifera / Q000737:chemistry* / Q000378:metabolism; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D054830:Sesterterpenes
keywords: 24-methoxypetrosaspongia C; Hyrtios erectus; Red Sea sponge; cancer cell lines; growth inhibitory activity; scalarane sesterterpenes