title: Serum LBP Is Associated with Insulin Resistance in Women with PCOS.
abstract: BACKGROUND
  Lipopolysaccharide-binding protein (LBP) is closely associated with many metabolic disorders. However, no study has been done to explore the relationship between LBP and polycystic ovary syndrome (PCOS). The objective of this study was to investigate whether the serum LBP level is elevated and associated with insulin resistance (IR) in PCOS.
  
  
  METHODS
  In this cross-sectional study, 117 PCOS patients and 121 age-matched controls were recruited. Hyperinsulinemic-euglycemic clamp was performed with an expression of M value for insulin sensitivity. Fasting serum samples were collected to detect LBP, lipids, insulin, sex hormones and high sensitive C reactive protein (hs-CRP). Pearson's correlation and multiple linear regression was used to analyze the associations between M value and LBP level.
  
  
  METHODS
  The study was performed in a clinical research center.
  
  
  RESULTS
  Compared with controls, PCOS subjects had a significantly higher LBP concentration (33.03±14.59 vs. 24.35±10.31 μg/ml, p<0.001), and lower M value (8.21±3.06 vs. 12.31±1.72 mg/min/kg, p<0.001). Both in lean and overweight/obese individuals, serum LBP level was higher in PCOS subjects than that in controls. M value was negatively correlated with body mass index (BMI), fasting serum insulin, triglycerides, low-density lipoprotein cholesterol (LDL-c), free testosterone, high sensitive C reactive protein (hs-CRP) and LBP, whereas positively correlated with high-density lipoprotein cholesterol (HDL-c) and sex hormone binding globulin (SHBG). Serum LBP level was associated with M value after adjusting for BMI, fasting serum insulin, SHBG, as well as hs-CRP.
  
  
  CONCLUSIONS
  Serum LBP level significantly is elevated in PCOS, and is independently associated with IR in PCOS.
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Qibo
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Zhou
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Aipin
authors.initials: A
authors.lastname: Zhang
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Rufei
authors.initials: R
authors.lastname: Gao
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Yang
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Changhong
authors.initials: C
authors.lastname: Zhao
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Hu
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Richa
authors.initials: R
authors.lastname: Goswami
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Lilin
authors.initials: L
authors.lastname: Gong
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
authors.forename: Qifu
authors.initials: Q
authors.lastname: Li
mesh_terms: D000209:Acute-Phase Proteins; D000328:Adult; D015992:Body Mass Index; D002352:Carrier Proteins / Q000097:blood*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D008562:Membrane Glycoproteins / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000503:physiopathology; D050177:Overweight / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein