title: [Locally Advanced Breast Cancer Treated with Halsted's Operation Because of Drug-Induced Lung Injury Caused by Neoadjuvant Chemotherapy--A Case Report].
abstract: A 64-year-old woman discovered a mass in her left breast and visited our hospital. A thorough examination resulted in a diagnosis of left, locally advanced breast cancer (cT4bN3, M0, cStage Ⅲc) with muscle invasion and Level Ⅲ lymph node metastases. Because of drug-induced lung disease following 4 courses of adriamycin and cyclophosphamide, the chemotherapy had to be stopped. Halsted's operation and postoperative radiotherapy (50 Gy) were performed. The patient was alive with no evidence of recurrence 9 months after surgery. Although multidisciplinary therapy is recommended in locally advanced breast cancer, chemotherapy sometimes cannot be performed due to factors such as age and physical status. Halsted's operation could be considered as a treatment of choice in patients with locally advanced breast cancer. It is important to choose the treatment strategy based on the condition of the patient.
authors.affiliation: Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Moro
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nagahashi
authors.forename: Junko
authors.initials: J
authors.lastname: Tsuchida
authors.forename: Kumiko
authors.initials: K
authors.lastname: Tatsuda
authors.forename: Chie
authors.initials: C
authors.lastname: Toshikawa
authors.forename: Miki
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Shimada
authors.forename: Jun
authors.initials: J
authors.lastname: Sakata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kameyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Minagawa
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kosugi
authors.forename: Yu
authors.initials: Y
authors.lastname: Koyama
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Wakai
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D055370:Lung Injury / Q000139:chemically induced*; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D064726:Triple Negative Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide