title: Computational postprocessing quantification of small bowel motility using magnetic resonance images in clinical practice: An initial experience.
abstract: To study the feasibility and to gauge the potential clinical impact of quantifying small bowel motility using magnetic resonance imaging (MRI) in a larger population with a spectra of gastrointestinal conditions with impaired small bowel motility.
  
  
  
  Data were gathered retrospectively from a cohort of 127 patients undergoing MR enterography (1.5 Tesla) in 2011. Cine motility sequences were processed with validated motility analysis software and a parametric motility map was generated. Regions of interests were drawn in the jejunum, ileum, and terminal ileum, and Jacobian standard deviation mean motility index' score (MIS) was calculated. Patients were divided into Crohn's disease (CD), ulcerative colitis, irritable bowel syndrome, and healthy subjects.
  
  
  
  In CD, terminal ileum motility was lower in comparison to healthy subjects (mean difference: -0.1052 arbitrary units, 95% confidence interval: -0.1981--0.0122, P = 0.018). Subgrouping of CD showed that the difference was recognized in patients with disease limited to the small bowel (mean difference: -0.1440 arbitrary units, 95% confidence interval: -0.2491--0.0389, P = 0.002). Visible dysmotility of terminal ileum on MRI reflected a reduced MIS compared with normal motility (0.22 ± 0.09 and 0.33 ± 0.15 arbitrary units, respectively, P = 0.043). Motility correlated negatively between ileum and age (P = 0.021), and between terminal ileum and C-reactive protein in ulcerative colitis (P = 0.031).
  
  
  
  Motility quantitation revealed a significant difference in motility of terminal ileum in patients with small bowel CD compared with healthy subjects, concording with visible dysmotility and inflammatory changes. J. Magn. Reson. Imaging 2016;44:277-287.
authors.affiliation: Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Malmö, Lund University, Sweden.
authors.forename: André
authors.initials: A
authors.lastname: Åkerman
authors.affiliation: Medical Radiation Physics, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.
authors.forename: Sven
authors.initials: S
authors.lastname: Månsson
authors.affiliation: Department of Imaging and Function, Lund University, Skåne University Hospital, Malmö, Sweden.
authors.forename: Frans-Thomas
authors.initials: FT
authors.lastname: Fork
authors.affiliation: Department of Imaging and Function, Lund University, Skåne University Hospital, Malmö, Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Leander
authors.affiliation: Department of Imaging and Function, Lund University, Skåne University Hospital, Malmö, Sweden.
authors.forename: Olle
authors.initials: O
authors.lastname: Ekberg
authors.affiliation: Centre for Medical Imaging, University College London, London, United Kingdom.
authors.forename: Stuart
authors.initials: S
authors.lastname: Taylor
authors.affiliation: Centre for Medical Imaging, University College London, London, United Kingdom.
authors.forename: Alex
authors.initials: A
authors.lastname: Menys
authors.affiliation: Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Malmö, Lund University, Sweden.
authors.forename: Bodil
authors.initials: B
authors.lastname: Ohlsson
mesh_terms: D000328:Adult; D000465:Algorithms; D005240:Feasibility Studies; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D007421:Intestine, Small / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D043183:Irritable Bowel Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Crohn's disease; magnetic resonance enterography (MRE); motility; motility index score; small bowel