title: [A Case of Bone Metastasis from Early Gastric Cancer after a Five-Year Disease-Free Interval Following Gastrectomy].
abstract: A woman in her 50s underwent distal gastrectomy and D1+b dissection in December 2005 for early gastric cancer that was diagnosed as a signet-ring-cell carcinoma, fStage Ⅱ (T1a, N2, H0, P0, CY0, M0) with 12 lymph node metastases in the second field. Multiple bone metastases were diagnosed on the basis of CT and bone scintigraphy findings and serum ALP elevation (2,743 IU/L) I n December 2010. Fourteen courses of S-1 plus CDDP and 4 mg of zoledronate were administered from January to September in 2011. Pancytopenia, D-dimmer elevation, myelocytes, and metamyelocytes were observed in October 2012, indicating she had bone marrow metastasis. She was treated with a transfusion, anti-DIC therapy, and paclitaxel. She died from gastric cancer in December 2012. We report a rare case of recurrence with bone metastasis from early gastric cancer. S-1 plus CDDP chemotherapy and zoledronate therapy is an effective treatments for multiple bone metastases from gastric cancer.
authors.affiliation: Dept. of Surgery, Sakai City Medical Center.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kimura
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Makari
authors.forename: Johta
authors.initials: J
authors.lastname: Mikami
authors.forename: Tomono
authors.initials: T
authors.lastname: Kawase
authors.forename: Takuya
authors.initials: T
authors.lastname: Hamakawa
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Hoshino
authors.forename: Ken
authors.initials: K
authors.lastname: Nakata
authors.forename: Tameyoshi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Jun
authors.initials: J
authors.lastname: Yamamura
authors.forename: Shunji
authors.initials: S
authors.lastname: Kamigaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Ikeda
authors.forename: Masaki
authors.initials: M
authors.lastname: Tsujie
authors.forename: Satoru
authors.initials: S
authors.lastname: Munakata
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ohzato
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin