title: Diminished ovarian reserve: is it a neglected cause in the assessment of recurrent miscarriage? A cohort study.
abstract: To study whether diminished ovarian reserve is associated with recurrent miscarriage.
  
  
  
  Cross-sectional clinical study.
  
  
  
  Tertiary-care center.
  
  
  
  Women with history of recurrent miscarriage (RM; n = 71) and sequentially selected age-matched fertile women who were seeking contraception (control; n = 70).
  
  
  
  Not applicable.
  
  
  
  Serum levels of FSH, LH, E2, and antimüllerian hormone (AMH); FSH/LH ratio; ovarian volumes; and antral follicle count (AFC).
  
  
  
  The levels of FSH were 8.6 ± 3.7 U/L in the RM group and 7.1 ± 3.9 U/L in the control group; this difference was statistically significant. The levels of AMH were significantly lower in the RM group than in the control group (2.9 ± 1.7 ng/mL vs. 3.6 ± 1.7 ng/mL). The percentage of women with levels of FSH ≥11 U/L was significantly higher in the RM group than in the control group (18.3% vs. 4.3%). In the RM group, the percentage of women with levels of AMH ≤1 ng/mL was significantly higher than in the control group (19.7% vs. 5.7%).
  
  
  
  Recurrent miscarriage may be associated with diminished ovarian reserve. Larger prospective randomized controlled trials are warranted to better determine the predictive potential of ovarian reserve markers in recurrent miscarriage.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Giresun University, Giresun, Turkey.
authors.forename: Melahat
authors.initials: M
authors.lastname: Atasever
authors.affiliation: Department of Obstetrics and Gynecology, Istanbul Education and Research Hospital, Ministry of Health, Istanbul, Turkey. Electronic address: zeynep.soyman@gmail.com.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Soyman
authors.affiliation: Department of Obstetrics and Gynecology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Demirel
authors.affiliation: Department of Obstetrics and Gynecology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Gencdal
authors.affiliation: Department of Obstetrics and Gynecology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey.
authors.forename: Sefa
authors.initials: S
authors.lastname: Kelekci
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000175:diagnosis*; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D065851:Ovarian Reserve / Q000502:physiology*; D011247:Pregnancy
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Antimüllerian hormone; antral follicle count; diminished ovarian reserve; ovarian reserve markers; recurrent miscarriage