title: Strategies to Enhance the Effectiveness of Adult Stem Cell Therapy for Ischemic Heart Diseases Affecting the Elderly Patients.
abstract: Myocardial infarctions and chronic ischemic heart disease both commonly and disproportionately affect elderly patients more than any other patient population. Despite available treatments, heart tissue is often permanently damaged as a result of cardiac injury. This review aims to summarize recent literature proposing the use of modified autologous adult stem cells to promote healing of post-infarct cardiac tissue. This novel cellular treatment involves isolation of adult stem cells from the patient, in vitro manipulation of these stem cells, and subsequent transplantation back into the patient's own heart to accelerate healing. One of the hindrances affecting this process is that cardiac issues are increasingly common in elderly patients, and stem cells recovered from their tissues tend to be pre-senescent or already in senescence. As a result, harsh in vitro manipulations can cause the aged stem cells to undergo massive in vivo apoptosis after transplantation. The consensus in literature is that inhibition or reversal of senescence onset in adult stem cells would be of utmost benefit. In fact, it is believed that this strategy may lower stem cell mortality and coerce aged stem cells into adopting more resilient phenotypes similar to that of their younger counterparts. This review will discuss a selection of the most efficient and most-recent strategies used experimentally to enhance the effectiveness of current stem cell therapies for ischemic heart diseases.
authors.affiliation: Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, 12208, USA.
authors.forename: Roshni
authors.initials: R
authors.lastname: Khatiwala
authors.affiliation: Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, 12208, USA. caic@mail.amc.edu.
authors.forename: Chuanxi
authors.initials: C
authors.lastname: Cai
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006321:Heart / Q000502:physiology; D006801:Humans; D017202:Myocardial Ischemia / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods
keywords: Cell senescence; Cell survival; Heart failure; Myocardial infarction; Preconditioning; Rejuvenation; Stem cell