title: Effect of incorporating antifungals on the water sorption and solubility of interim resilient liners for denture base relining.
abstract: BACKGROUND
  Incorporating antifungals into interim denture resilient liners has been proposed to prolong their clinical longevity and to treat denture stomatitis. However, information is lacking on the effect of this addition on water sorption and solubility.
  
  
  OBJECTIVE
  The purpose of this in vitro study was to evaluate the addition of minimum inhibitory concentrations (MICs) of antifungals for Candida albicans biofilm on the water sorption (WS) and solubility of interim denture resilient liners.
  
  
  METHODS
  Disk-shaped specimens (n=10; 50×0.5 mm) of tissue conditioner (Softone) and resilient liner (Trusoft) were created either without (control) or with the incorporation of 1 of the 3 following drugs at MICs (g of drug per g of resilient material powder): nystatin (Ny, 0.032g/g), chlorhexidine diacetate (Chx, 0.064g/g), and ketoconazole (Ke, 0.128g/g). Specimens were dried; immersed in water for 24 hours and 7 or 14 days; weighed, dried, and weighed again. Data (μg/mm(3)) were analyzed by 3-way ANOVA followed by the Tukey-Kramer honest significant differences test (α=.05).
  
  
  RESULTS
  At the 14-day interval, only the addition of Chx (483.0 ±61.0 μg/mm(3)) increased the WS of the tissue conditioner compared with the control group (244.0 ±42.0 μg/mm(3); P<.001). For all periods, the solubility of both materials increased with the addition of Chx (27.7 ±6.1 μg/mm(3)) and Ke (30.9 ±5.3 μg/mm(3)) compared with the control group (22.5 ±6.0 μg/mm(3); P<.001).
  
  
  CONCLUSIONS
  After 14 days, the addition of Ny and Ke at MICs in both Softone and Trusoft and addition of Chx in Trusoft did not affect WS. The solubility of the 2 interim materials was not altered by the addition of Ny for up to 14 days.
authors.affiliation: Postgraduate student, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Jozely F M
authors.initials: JF
authors.lastname: Lima
authors.affiliation: Postgraduate student, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Janaina G
authors.initials: JG
authors.lastname: Maciel
authors.affiliation: Assistant Professor, Department of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil.
authors.forename: César A G
authors.initials: CA
authors.lastname: Arrais
authors.affiliation: Associate Professor, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Vinícius C
authors.initials: VC
authors.lastname: Porto
authors.affiliation: Assistant Professor, Department of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil. Electronic address: vanurban@yahoo.com.
authors.forename: Vanessa M
authors.initials: VM
authors.lastname: Urban
authors.affiliation: Assistant Professor, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Karin H
authors.initials: KH
authors.lastname: Neppelenbroek
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects; D002180:Candidiasis, Oral / Q000517:prevention & control; D003819:Denture Bases; D003823:Denture Rebasing / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D014867:Water / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D014867:Water