title: Thalidomide for the treatment of angiodysplasia in a patient with acute upper gastrointestinal haemorrhage.
abstract: Gastrointestinal (GI) angiodysplasia is an important and challenging cause of acute GI haemorrhage, particularly in the elderly. We present the case of an 83-year-old woman admitted with acute upper GI bleeding that was refractory to both endoscopic ablation with argon plasma coagulation and gastroduodenal artery embolisation. Administration of thalidomide 100 mg daily after failure of the above therapeutic procedures resulted in cessation of bleeding and avoided the need for further blood transfusion at 6-month follow-up.
authors.affiliation: Department of Wales Deanery, Cardiff University, Cardiff, UK Ysbyty Gwynedd, Bangor, Gwynedd, UK.
authors.forename: Adam
authors.initials: A
authors.lastname: Bond
authors.affiliation: Department of Gastroenterology, Ysbyty Gwynedd, Bangor, Gwynedd, UK.
authors.forename: Waqar
authors.initials: W
authors.lastname: Ahmed
mesh_terms: D000208:Acute Disease; D000369:Aged, 80 and over; D016888:Angiodysplasia / Q000150:complications / Q000188:drug therapy*; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D004724:Endoscopy / Q000379:methods; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D013792:Thalidomide / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D013792:Thalidomide