title: A Sequential Homologation of Alkynes and Aldehydes for Chain Elongation with Optional (13)C-Labeling.
abstract: Terminal alkynes (RCCH) are homologated by a sequence of ruthenium-catalyzed anti-Markovnikov hydration of alkyne to aldehyde (RCH2CHO), followed by Bestmann-Ohira alkynylation of aldehyde to chain-elongated alkyne (RCH2CCH). Inverting the sequence by starting from aldehyde brings about the reciprocal homologation of aldehydes instead. The use of (13)C-labeled Bestmann-Ohira reagent (dimethyl ((1-(13)C)-1-diazo-2-oxopropyl)phosphonate) for alkynylation provides straightforward access to singly or, through additional homologation, multiply (13) C-labeled alkynes. The labeled alkynes serve as synthetic platform for accessing a multitude of specifically (13)C-labeled products. Terminal alkynes with one or two (13)C-labels in the alkyne unit have been submitted to alkyne-azide click reactions; the copper-catalyzed version (CuAAC) was found to display a regioselectivity of >50,000:1 for the 1,4- over the 1,5-triazine isomer, as shown analytically by (13)C NMR spectroscopy.
authors.affiliation: Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85748, Garching bei München, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Brunner
authors.affiliation: Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85748, Garching bei München, Germany. lukas.hintermann@tum.de.
authors.forename: Lukas
authors.identifier: http://orcid.org/0000-0003-2622-8663
authors.initials: L
authors.lastname: Hintermann
keywords: alkynes; click chemistry; homogeneous catalysis; ruthenium; synthetic methods