title: Prevalence of Beijing family in Mycobacterium tuberculosis in world population: Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  In this present study we decided to consider the prevalence and distribution of Beijing family in the world using meta-analysis based on systematic review of articles published and relation with drug resistance, which will provide more detailed information to clearly overview the status of this family and transmission of TB.
  
  
  METHODS
  This study used the most available article published in literature database including PubMed, Science direct, Web of Science, Google Scholar, Biological abs, Iranmedex, and SID systematically reviewed prevalence of Beijing family. Data analyzed using meta-analysis with random effects models.
  
  
  RESULTS
  Final analyses included 264 samples that have been selected from 2811 studies. Overall Beijing family prevalence in world was estimated to be 33.2% (95% CI 31.4-35.2). Corresponding estimates by continent were Asia 44.7% (39.5-49.8), Europe 27.9% (25.6-30.1), Africa 12·5% (8.9-16.2), and America 8.9% (6.9-10.9). In all world regions, Beijing families were associated with drug resistance 81.37%.
  
  
  CONCLUSIONS
  According to the results, prevalence of Beijing family in Asia is higher than similar studies in other parts of the world and this family is associated with drug resistance. Effective control program is needed in world to control the spread of drug resistance strains specially Beijing family.
authors.affiliation: Cellular & Molecular Research Center and Microbiology Department, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic address: atrop_t51@yahoo.com.
authors.forename: Rashid
authors.initials: R
authors.lastname: Ramazanzadeh
authors.affiliation: Center for Prevention of Psychosocial Trauma, Ilam University of Medical Science, Ilam, Iran.
authors.forename: Kourosh
authors.initials: K
authors.lastname: Sayhemiri
keywords: Beijing; M. tuberculosis; Meta-analysis; Prevalence