title: Comparison of Cerebral Oxygen Saturation and Cerebral Perfusion Computed Tomography in Cerebral Blood Flow in Patients with Brain Injury.
abstract: The purpose of this study was to determine the relationship between cerebral tissue oxygen saturation and cerebral blood volume in patients with traumatic brain injury. Perfusion computed tomography of the brain was performed in 25 patients with traumatic brain injury together with simultaneous SctO2 level measurement using cerebral near-infrared oxymetry. The mean age of the injured persons was 34.5±15.6 years (range 15-65); 14 men, 11 women. The Injury Severity Score (ISS) values were 44.4±9.7 (range 25-81). The Glasgow Coma Score (GCS) mean value before the study was 10.6±2.1 (range 5-13). SctO2 ranged from 51 to 89%, mean 62±8.2%. Cerebral blood volume (CBV) values were 2.1±0.67 ml/100 g (min 1.1; max 4.3 ml/100 g). Cerebral blood flow (CBF) was 31.99±13.6 ml/100 g×min. Mean transit time (MTT) values were 5.7±4.5 s (min 2.8; max 34.3 s). The time to peak (TTP) was 22.2±3.1 s. A statistically significant correlation was found between SctO2 level and cerebral blood volume (CBV) level (R=0.9; p<0.000001). No other significant correlations were found between brain tissue oxygenation and other parameters of brain perfusion.
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin str., Nizhniy Novgorod, 603950, Russia. xtro7@mail.ru.
authors.forename: Alexey O
authors.initials: AO
authors.lastname: Trofimov
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin str., Nizhniy Novgorod, 603950, Russia.
authors.forename: George
authors.initials: G
authors.lastname: Kalentiev
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin str., Nizhniy Novgorod, 603950, Russia.
authors.forename: Oleg
authors.initials: O
authors.lastname: Voennov
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin str., Nizhniy Novgorod, 603950, Russia.
authors.forename: Vera
authors.initials: V
authors.lastname: Grigoryeva
mesh_terms: D001810:Blood Volume; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D055420:Perfusion Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D010100:Oxygen
keywords: Head injury; NIRS; Perfusion CT