title: Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet.
abstract: We show that hypercholesterolemia contributes to oxidative stress injury progression in brain and simvastatin counteracts the cholesterol-induced peroxidation injury in rabbit hippocampus, and we demonstrate for the first time that the simvastatin is a critical role in brain protection and identify HO-1 and other related antioxidant enzymes as molecular target for active redox compounds. Second, our experiments have pointed out an association between statin treatment and a decrease in the risk of having peroxidation damage of brain. The balance effects of simvastatin to ROS and antioxidants enzymes network are most probably due to improved SOD functional activity, increase in GSH-Px, increase in HO-1 expression, and decrease of MDA generation.
authors.affiliation: Department of Psychosomatic, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China.
authors.forename: Guangyin
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Geriatrics, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China.
authors.forename: Yinzhi
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Li
authors.initials: L
authors.lastname: Peng
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Yang
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: First Teaching Hospital of Tianjin University of TCM, Room 309, Office Building, No. 314, An Shan Xi Road, Nankai District, Tianjin 300193, China.
authors.forename: Junping
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects* / Q000473:pathology; D050197:Atherosclerosis / Q000473:pathology; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D051547:Heme Oxygenase-1 / Q000235:genetics / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011817:Rabbits; D019821:Simvastatin / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D012333:RNA, Messenger; D019821:Simvastatin; D051547:Heme Oxygenase-1