title: Advances in drug delivery system for platinum agents based combination therapy.
abstract: Platinum-based anticancer agents are widely used as first-line drugs in cancer chemotherapy for various solid tumors. However, great side effects and occurrence of resistance remain as the major drawbacks for almost all the platinum drugs developed. To conquer these problems, new strategies should be adopted for platinum drug based chemotherapy. Modern nanotechnology has been widely employed in the delivery of various therapeutics and diagnostic. It provides the possibility of targeted delivery of a certain anticancer drug to the tumor site, which could minimize toxicity and optimize the drug efficacy. Here, in this review, we focused on the recent progress in polymer based drug delivery systems for platinum-based combination therapy.
authors.affiliation: 1 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ; 2 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China ; 3 University of Chinese Academy of Sciences, Beijing 100049, China ; 4 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China ; 5 Shanghai Minimally Invasive Surgery Center, Shanghai 200025, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Kang
authors.affiliation: 1 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ; 2 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China ; 3 University of Chinese Academy of Sciences, Beijing 100049, China ; 4 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China ; 5 Shanghai Minimally Invasive Surgery Center, Shanghai 200025, China.
authors.forename: Hai-Hua
authors.initials: HH
authors.lastname: Xiao
authors.affiliation: 1 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ; 2 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China ; 3 University of Chinese Academy of Sciences, Beijing 100049, China ; 4 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China ; 5 Shanghai Minimally Invasive Surgery Center, Shanghai 200025, China.
authors.forename: Hai-Qin
authors.initials: HQ
authors.lastname: Song
authors.affiliation: 1 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ; 2 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China ; 3 University of Chinese Academy of Sciences, Beijing 100049, China ; 4 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China ; 5 Shanghai Minimally Invasive Surgery Center, Shanghai 200025, China.
authors.forename: Xia-Bin
authors.initials: XB
authors.lastname: Jing
authors.affiliation: 1 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ; 2 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China ; 3 University of Chinese Academy of Sciences, Beijing 100049, China ; 4 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China ; 5 Shanghai Minimally Invasive Surgery Center, Shanghai 200025, China.
authors.forename: Le-San
authors.initials: LS
authors.lastname: Yan
authors.affiliation: 1 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ; 2 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China ; 3 University of Chinese Academy of Sciences, Beijing 100049, China ; 4 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China ; 5 Shanghai Minimally Invasive Surgery Center, Shanghai 200025, China.
authors.forename: Ruo-Gu
authors.initials: RG
authors.lastname: Qi
keywords: Cancer; combination therapy; drug delivery; platinum