title: Catechin-Modified Polylactide Stereocomplex at Chain End Improved Antibiobacterial Property.
abstract: Using different type of initiators, the antibacterial moieties are introduced at the chain end of poly(L,L-lactide) (PLLA) and poly(D,D-lactide) (PDLA), and the thermal properties are simultaneously improved using the stereocomplex approach. The physical interaction of polymers and antibacterial compounds is investigated. The double bonds at the chain end are utilized for the interaction of silver ion; however, the silver ions are not detected after stereocomplexation of PLLA and PDLA. On the other hand, catechin (CT) is selected as an initiator precursor of lactide polymerization, protecting the phenolic hydroxyl groups. The linear PLLA and PDLA are obtained by the initiator, resulting in CT conjugated PLAs at the chain end groups after deprotection of phenolic hydroxyl groups. The antibacterial properties are determined by proliferation tests of staphylococcus aureus. The results suggest that the antibacterial properties of CT modified PLAs are derived from the original CT parts.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.|Institute for Research Initiatives, Division for Research Strategy, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.|JST PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.|Department of Applied Chemistry, Osaka University, 2-1, Yamada-oka, Suita, 565-0871, Japan.|The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
authors.forename: Hiroharu
authors.initials: H
authors.lastname: Ajiro
authors.affiliation: Department of Applied Chemistry, Osaka University, 2-1, Yamada-oka, Suita, 565-0871, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Ito
authors.affiliation: Institute for Research Initiatives, Division for Research Strategy, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara, 630-0192, Japan.
authors.forename: Kai
authors.initials: K
authors.lastname: Kan
authors.affiliation: Department of Applied Chemistry, Osaka University, 2-1, Yamada-oka, Suita, 565-0871, Japan.|The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.|Graduate School of Frontier Biosciences, Osaka University, 2-1 Yamada-oka, Suita, 565-0871, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Akashi
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002392:Catechin / Q000737:chemistry; D006801:Humans; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D014867:Water; C033616:poly(lactide); D002392:Catechin
keywords: antibacterial; biomaterials; polylactide; stereo­complex; thin films