title: Recent insights into the biological activities and drug delivery systems of tanshinones.
abstract: Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the prospective biomedical applications of these compounds. Numerous pharmacological activities, including anti-inflammatory, anticancer, and cardio-cerebrovascular protection activities, are exhibited by the three primary bioactive constituents among the tanshinones, ie, tanshinone I (TNI), tanshinone IIA (TNIIA), and cryptotanshinone (CPT). However, due to their poor solubility and low dissolution rate, the clinical applications of TNI, TNIIA, and CPT are limited. To solve these problems, many studies have focused on loading tanshinones into liposomes, nanoparticles, microemulsions, cyclodextrin inclusions, solid dispersions, and so on. In this review, we aim to offer an updated summary of the biological activities and drug delivery systems of tanshinones to provide a reference for these constituents in clinical applications.
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People's Republic of China.
authors.forename: Yuee
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Wenji
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, FL, USA.
authors.forename: Zirong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People's Republic of China; Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People's Republic of China.
authors.forename: Chengwei
authors.initials: C
authors.lastname: He
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People's Republic of China.
authors.forename: Meiwan
authors.initials: M
authors.lastname: Chen
mesh_terms: D045784:Abietanes / Q000008:administration & dosage / Q000494:pharmacology*; D003505:Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D004655:Emulsions / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D010616:Phenanthrenes / Q000008:administration & dosage / Q000494:pharmacology*; D027561:Salvia miltiorrhiza / Q000737:chemistry; D012995:Solubility
chemical_list: D045784:Abietanes; D003505:Cyclodextrins; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D008081:Liposomes; D010616:Phenanthrenes; C021751:tanshinone; C037886:cryptotanshinone
keywords: bioavailability; biological activities; drug delivery systems; solubility; tanshinones