title: [Endocrine consequences in young adult survivors of childhood cancer treatment].
abstract: Endocrine complications (particularly gonadal, hypothalamic-pituitary and metabolic) of childhood cancer treatments are common in young adults. Gonadal damage may be the result of chemotherapy or radiotherapy. Fertility preservation must be systematically proposed before initiation of gonadotoxic treatment if only the child is eligible. Hypothalamic-pituitary deficiency is common after brain or total-body irradiation, the somatotropic axis is the most sensitive to irradiation. Pituitary deficiency screening must be repeated since this endocrine consequence can occur many years after treatment. Hormone replacement must be prudent particularly in case of treatment with growth hormone or steroids. Metabolic syndrome, diabetes and cardiovascular damage resulting from cancer treatments contribute to the increase of morbidity and mortality in this population and should be screened routinely even if the patient is asymptomatic. The multidisciplinary management of these adults must be organized and the role of the endocrinologist is now well established.
authors.affiliation: Service d'Endocrinologie, Diabétologie, Maladies Métaboliques, Hôpital Claude Huriez, CHRU de Lille, Rue Michel Polonovski, 59037 Lille cedex, France; Service d'Andrologie, Hôpital Calmette, CHRU de Lille, Boulevard du Professeur Jules Leclercq, 59037 Lille cedex, France; Service d'Endocrinologie et Diabétologie Pédiatrique, Hôpital Jeanne de Flandre, CHRU de Lille, avenue Eugène Avinée, 59037 Lille cedex, France; Université Lille 2, Faculté de Médecine, Lille, France. Electronic address: clara.leroy@chru-lille.fr.
authors.forename: C
authors.initials: C
authors.lastname: Leroy
authors.affiliation: Service d'Endocrinologie, Diabétologie, Maladies Métaboliques, Hôpital Claude Huriez, CHRU de Lille, Rue Michel Polonovski, 59037 Lille cedex, France; Université Lille 2, Faculté de Médecine, Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Cortet-Rudelli
authors.affiliation: Service d'Endocrinologie, Diabétologie et Nutrition, CHRU d'Amiens, UPJV, Hôpital Sud, Avenue René Laennec 80054 Amiens cedex 1, France; Université de Picardie Jules Verne, Faculté de Médecine, Amiens, France.
authors.forename: R
authors.initials: R
authors.lastname: Desailloud
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D004700:Endocrine System Diseases / Q000209:etiology*; D005260:Female; D059247:Fertility Preservation; D006066:Gonads / Q000187:drug effects / Q000528:radiation effects; D020249:Hormone Replacement Therapy; D006801:Humans; D007027:Hypothalamic Diseases / Q000209:etiology; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology; D009369:Neoplasms / Q000628:therapy*; D010900:Pituitary Diseases / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D017741:Survivors; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents
keywords: Acquired hypothalamic-pituitary deficiency; Adultes survivants à un cancer dans l'enfance; Conséquences endocriniennes des anti-cancéreux; Endocrine complications of cancer treatments; Insuffisance hypothalamo-hypophysaire acquise; Metabolic and cardiovascular risk; Preservation of fertility; Préservation de fertilité; Risque métabolique et cardiovasculaire; Survivor of childhood cancers