title: Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease.
abstract: Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many of the functions of IL-22 in the intestine are incompletely understood, this review is meant to assess our current understanding of the roles of IL-22 and provide new opportunities for inquiry to improve human intestinal health and disease.
authors.affiliation: Department of Pediatrics, University of Pittsburgh School of Medicine Pittsburgh, PA, USA.
authors.forename: Olivia B
authors.initials: OB
authors.lastname: Parks
authors.affiliation: Department of Pediatrics, University of Pittsburgh School of MedicinePittsburgh, PA, USA; Department of Pediatrics, Richard King Mellon Foundation Institute for Pediatric Research, University of Pittsburgh School of MedicinePittsburgh, PA, USA.
authors.forename: Derek A
authors.initials: DA
authors.lastname: Pociask
authors.affiliation: Department of Pediatrics, University of Pittsburgh School of Medicine Pittsburgh, PA, USA.
authors.forename: Zerina
authors.initials: Z
authors.lastname: Hodzic
authors.affiliation: Department of Pediatrics, University of Pittsburgh School of MedicinePittsburgh, PA, USA; Department of Pediatrics, Richard King Mellon Foundation Institute for Pediatric Research, University of Pittsburgh School of MedicinePittsburgh, PA, USA.
authors.forename: Jay K
authors.initials: JK
authors.lastname: Kolls
authors.affiliation: Department of Pediatrics, University of Pittsburgh School of MedicinePittsburgh, PA, USA; Division of Newborn Medicine, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of MedicinePittsburgh, PA, USA.
authors.forename: Misty
authors.initials: M
authors.lastname: Good
keywords: barrier defense; epithelial cells; gastrointestinal tract; interleukin-22