title: Management of a Resistant Hypotension Developing After Reperfusion of a Living-Donor Kidney Transplant.
abstract: We present a case of hypotension developing after reperfusion of a living-donor kidney transplant and performing a graft nephrectomy and successful retransplant with the same kidney 12 hours later. Preemptive kidney transplant was performed on a 51-year-old woman who had a chronic kidney disease because of hypertension. Her 55-year-old husband was the living kidney donor. The patient was stable before reperfusion. After declamping, pink color of the transplanted kidney, thrill from the renal artery, and urinary output were seen. But shortly after reperfusion, the invasive arterial blood pressure of the patient abruptly decreased from 130/70 mm Hg to 70/40 mm Hg, her pulse was approximately 80 to 110 beats/minute. The thrill disappeared from the renal artery, but blood flow continued. A graft nephrectomy was performed 45 minutes after reperfusion. Invasive arterial blood pressure of the patient was stabilized at approximately 110/70 mm Hg in the intensive care unit, and the patient was retransplanted with the same kidney. The patient was well, with a serum creatinine level of 1.4 mg/dL, 12 months after the operation. Resistant hypotension that occurs after kidney transplant may cause a loss of the graft and the patient. To prevent graft loss, and to stabilize the patient, a graft nephrectomy and retransplant of the graft under suitable circumstances may be considered.
authors.affiliation: From the Diyarbakir Education and Research Hospital, Transplantation Center, Diyarbakir, Turkey.
authors.forename: Nurettin
authors.initials: N
authors.lastname: Ay
authors.forename: Sedat
authors.initials: S
authors.lastname: Kaya
authors.forename: Melih
authors.initials: M
authors.lastname: Anil
authors.forename: Vahhac
authors.initials: V
authors.lastname: Alp
authors.forename: Utkan
authors.initials: U
authors.lastname: Sevuk
authors.forename: Ramazan
authors.initials: R
authors.lastname: Danis
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D004351:Drug Resistance; D005260:Female; D006085:Graft Survival; D006801:Humans; D007022:Hypotension / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D020127:Recovery of Function; D012086:Reoperation; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents