title: Rapid Access to 2-Methylene Tetrahydrofurans and γ-Lactones: A Tandem Four-Step Process.
abstract: A one-pot tandem process involving hydrolysis, Knoevenagel condensation, Michael addition, and Conia-ene (HKMC) reactions has been developed for the rapid synthesis of indanone-fused 2-methylene tetrahydrofurans from the reaction of enynals and propynols. In this process, two rings and four bonds are generated with 100 % atom-economy and high step-efficiency. The resulting tetrahydrofurans were readily oxidized into α-methylene γ-lactones, which are one of the most important substructures in natural and bioactive compounds.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
authors.forename: Renxiao
authors.initials: R
authors.lastname: Liang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
authors.forename: Qiaohui
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
authors.forename: Jiantao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China. zhusf@scut.edu.cn.|State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China. zhusf@scut.edu.cn.
authors.forename: Shifa
authors.initials: S
authors.lastname: Zhu
keywords: cyclizations; heterocycles; indium; lactones; synthetic methods