title: The endothelium as the common denominator in malignant hypertension and thrombotic microangiopathy.
abstract: The endothelium plays a pivotal role in vascular biology. The endothelium is the primary site of injury in thrombotic microangiopathies including malignant hypertension. Endothelial injury in thrombotic microangiopathies is the result of increased shear stress, toxins, and/or dysregulated complement activation. Endothelial injury can lead to microvascular thrombosis resulting in ischemia and organ dysfunction, the clinical hallmarks of thrombotic microangiopathies. Currently, available therapies target the underlying mechanisms that lead to endothelial injury in these conditions. Ongoing investigations aim at identifying drugs that protect the endothelium.
authors.affiliation: Division of Nephrology, Department of Medicine, Albany Stratton VA Medical Center, Albany, NY, USA; Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ, USA. Electronic address: roy.mathew@va.gov.
authors.forename: Roy O
authors.initials: RO
authors.lastname: Mathew
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Nayer
authors.affiliation: Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ, USA.
authors.forename: Arif
authors.initials: A
authors.lastname: Asif
mesh_terms: D000071120:ADAMTS13 Protein / Q000235:genetics / Q000378:metabolism*; D003170:Complement Pathway, Alternative; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D006974:Hypertension, Malignant / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D057049:Thrombotic Microangiopathies / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*
chemical_list: D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human
keywords: Malignant hypertension; endothelial dysfunction; hemolytic uremic syndrome; thrombotic microangiopathy