title: Prevalence of the Factor XIII Val34Leu Polymorphism in Korean Patients with Deep Vein Thrombosis.
abstract: OBJECTIVE
  According to recent reports, a common polymorphism resulting in Val to Leu substitution, located 3 amino acids (Val34Leu) upstream of the thrombin cleavage site of FXIII A, has been related to a lower incidence of deep vein thrombosis (DVT). And, a different expression pattern has been shown across nations and races. However, the frequency of FXIII polymorphism expression in Koreans has not been reported in normal individuals or DVT-patient groups.
  
  
  METHODS
  Case-control study in Korean population.
  
  
  METHODS
  We investigated the distribution of factor XIII Val34Leu polymorphisms in Korean patients of DVT (50 cases) and Korean healthy controls (100 cases), using real-time polymerase chain reaction for single nucleotide polymorphism genotyping.
  
  
  RESULTS
  With regard to the frequency of the FXIII polymorphism in DVT patients and in the general control group, all 50 cases in the patient group and 100 cases in the control group were found to be Val34 homozygotes.
  
  
  CONCLUSIONS
  The Val34Leu polymorphism of FXIII was not found in Korean people, and compared with Caucasians, a noticeably low incidence of DVT was shown. Thus, the preventive effect of the Val34 allele of FXIII on the formation of thrombi was shown.
authors.affiliation: Division of Vascular and Endovascular Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Sang-Dong
authors.initials: SD
authors.lastname: Kim
authors.affiliation: Division of Vascular and Endovascular Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jeong-Kye
authors.initials: JK
authors.lastname: Hwang
authors.affiliation: Division of Vascular and Endovascular Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: sun60278@catholic.ac.kr.
authors.forename: Sun-Cheol
authors.initials: SC
authors.lastname: Park
authors.affiliation: Division of Vascular and Endovascular Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Ji-Il
authors.initials: JI
authors.lastname: Kim
authors.affiliation: Division of Vascular and Endovascular Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Yong-Sung
authors.initials: YS
authors.lastname: Won
authors.affiliation: Division of Vascular and Endovascular Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Sang-Seob
authors.initials: SS
authors.lastname: Yun
authors.affiliation: Division of Vascular and Endovascular Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: In-Sung
authors.initials: IS
authors.lastname: Moon
authors.affiliation: Division of Vascular and Endovascular Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jang-Sang
authors.initials: JS
authors.lastname: Park
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005176:Factor XIII / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005337:Fibrin / Q000378:metabolism / Q000648:ultrastructure; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D005337:Fibrin; D005176:Factor XIII