title: Chronic Daily Headache: Mechanisms and Principles of Management.
abstract: Primary headache is a common malady that is often under-recognized and frequently inadequately managed in spite of the fact that it affects up to 95 % of the population in a lifetime. Many forms of headache, including episodic tension and migraine headaches, if properly diagnosed, are reasonably amenable to treatment, but a smaller, though not insignificant, percent of the population suffer daily from a chronic, intractable form of headache that destroys one's productivity and quality of life. These patients are frequently seen in neurological practices at a point when treatment options are limited and largely ineffective. In the following review, we will discuss mechanisms drawn from recent studies that address the transition from acute to chronic pain that may apply to the transformation from episodic to chronic daily headaches which may offer opportunities for preempting headache transformation.
authors.affiliation: Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. avoigt@lsuhsc.edu.
authors.forename: Amy W
authors.initials: AW
authors.lastname: Voigt
authors.affiliation: Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. hgould@lsuhsc.edu.|Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. hgould@lsuhsc.edu.|Department of Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA. hgould@lsuhsc.edu.|Center of Excellence for Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. hgould@lsuhsc.edu.|Pain Mastery Center of Louisiana, Louisiana State University Health Sciences Center, New Orleans, LA, USA. hgould@lsuhsc.edu.
authors.forename: Harry J
authors.initials: HJ
authors.lastname: Gould
mesh_terms: D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003027:Cluster Headache / Q000503:physiopathology* / Q000523:psychology; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D018450:Disease Progression; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D020773:Headache Disorders / Q000503:physiopathology* / Q000517:prevention & control / Q000523:psychology / Q000628:therapy; D006801:Humans; D011788:Quality of Life; D040242:Risk Reduction Behavior; D018434:Sickness Impact Profile; D013312:Stress, Physiological
chemical_list: D002121:Calcium Channel Blockers; D018691:Excitatory Amino Acid Antagonists
keywords: Headache; Hyperalgesic priming; Management strategies; Transformed migraine