title: Long-term effects of duodenojejunal bypass on diabetes in Otsuka Long-Evans Tokushima Fatty rats.
abstract: BACKGROUND
  Previous studies have shown that duodenojejunal bypass (DJB) resolves type 2 diabetes. However, this finding has been contradicted by several experimental and human trials and therefore needs to be clarified.
  
  
  METHODS
  Otsuka Long-Evans Tokushima Fatty (OLETF) rats randomly underwent a sham operation or DJB. Thereafter, we measured daily body weight, serum levels of glucose and gut hormones such as glucagon-like peptide-1, insulin, and leptin.
  
  
  RESULTS
  There was no significant difference in weight loss between rats in the DJB and sham-operated groups. There were also no differences in the area under the curve of glucose tolerance between the DJB and sham-operated groups (32466 ± 2261 mg/dL·min vs. 26319 ± 427 mg/dL·min; p = 0.35). Duodenojejunal bypass did not affect plasma concentrations of various gut hormones such as glucagon-like peptide-1, insulin, and leptin.
  
  
  CONCLUSIONS
  We have shown that DJB alone does not improve glucose tolerance in obese, diabetic OLETF rats. Therefore, it may be that DJB alone is insufficient for diabetic control in obese diabetic rats. The addition of a restrictive component such as sleeve gastrectomy, or a new drug may be necessary for achieving diabetes reversal.
authors.affiliation: Department of Surgery, Daejeon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Daejeon, Republic of Korea.
authors.forename: Sang Kuon
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Biochemistry, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Oh-Joo
authors.initials: OJ
authors.lastname: Kwon
authors.affiliation: Department of Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, Catholic University of Korea, Uijeongbu, Republic of Korea.
authors.forename: Hae Myung
authors.initials: HM
authors.lastname: Jeon
authors.affiliation: Department of Surgery, Daejeon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Daejeon, Republic of Korea. Electronic address: sejoonkim@hanmail.net.
authors.forename: Say-June
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D050110:Bariatric Surgery / Q000379:methods*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000601:surgery*; D004386:Duodenum / Q000601:surgery*; D007583:Jejunum / Q000601:surgery*; D008297:Male; D009765:Obesity / Q000150:complications / Q000601:surgery; D011897:Random Allocation; D051381:Rats; D020334:Rats, Inbred OLETF; D016896:Treatment Outcome
keywords: Otsuka Long–Evans Tokushima Fatty rat; diabetes mellitus; diabetes remission; duodenojejunal bypass; glucose homeostasis