title: Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population.
abstract: OBJECTIVE
  Adiponectin has been implicated in the development of chronic obstructive pulmonary disease (COPD). The CDH13 gene encodes T-cadherin that is an adiponectin receptor, and genetic variants of CDH13 determine blood adiponectin levels. The aim of this study was to investigate the effects of CDH13 variants on COPD susceptibility in a Chinese population.
  
  
  METHODS
  Ten single-nucleotide polymorphisms (SNP) in CDH13 were screened using the SNaPshot method in 279 COPD patients and 367 control subjects. Association of genotypes or haplotypes constructed from these loci with COPD was analyzed in different genetic models.
  
  
  RESULTS
  Among the 10 SNPs tested, rs4783244 and rs12922394 exhibited significant differences in allele or genotype frequencies between COPD patients and control subjects, whereas 8 other SNPs did not. The minor allele T was associated with decreased risk of COPD in the recessive model at rs4783244 (OR=0.42, P=0.023) and in the dominant model at rs12922394 (OR=0.70, P=0.022). The genotype TT at either rs4783244 or rs12922394 was associated with a significantly low level of plasma adiponectin when compared to genotypes GG and CC (P<0.05). Haplotypes GC in block 1 (rs4783244-rs12922394) as well as GTAC and ATGT in block 3 (rs4783266-rs11640522-rs11646849-rs11860282) significantly increased the risk of COPD, whereas haplotypes TT in block 1, TG in block 2 (rs11646011- rs11640875) and ATGC in block 3 were protective against COPD.
  
  
  CONCLUSIONS
  CDH13 genetic variants determine Chinese individuals' susceptibility to COPD and thus are efficient genetic biomarkers for early detection of COPD.
authors.affiliation: Department of Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yi-ming
authors.initials: YM
authors.lastname: Yuan
authors.affiliation: Molecular Medicine Research Center, West China Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
authors.forename: Jin-long
authors.initials: JL
authors.lastname: Zhang
authors.affiliation: Respiratory Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Si-cheng
authors.initials: SC
authors.lastname: Xu
authors.affiliation: Department of Internal Medicine, The Affiliated Shanghai Eighth People's Hospital of Jiangsu University, Shanghai 200235, China.
authors.forename: Ren-song
authors.initials: RS
authors.lastname: Ye
authors.affiliation: Molecular Medicine Research Center, West China Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xu
authors.affiliation: Molecular Medicine Research Center, West China Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
authors.forename: You
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Molecular Medicine Research Center, West China Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
authors.forename: Yan-Jie
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: Molecular Medicine Research Center, West China Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
authors.forename: Yu-long
authors.initials: YL
authors.lastname: Chen
authors.affiliation: Molecular Medicine Research Center, West China Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
authors.forename: Yu-lan
authors.initials: YL
authors.lastname: Liu
authors.affiliation: Molecular Medicine Research Center, West China Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
authors.forename: Zhi-guang
authors.initials: ZG
authors.lastname: Su
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D044466:Asian People / Q000235:genetics; D015820:Cadherins / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008168:Lung / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology
chemical_list: D052242:Adiponectin; D015820:Cadherins; C099972:H-cadherin