title: The Role of Neutrophilic Inflammation, Angiotropism, and Pericytic Mimicry in Melanoma Progression and Metastasis.
abstract: Angiotropism in melanoma correlates with ulceration and poor prognosis. It has been shown to be a marker of pericytic mimicry, that is, the spreading of tumor cells in a pericyte location along abluminal vascular surfaces. Such extravascular tumor spread may represent another form of tumor plasticity with reversion to a neural crest cell migratory phenotype. In a murine melanoma model, it has recently been demonstrated that neutrophilic skin inflammation promotes angiotropism and metastatic spread of primary melanomas. This review discusses the role of neutrophilic inflammation in angiotropism and pericytic mimicry in melanoma progression, metastasis, tumor cell plasticity, and tumor therapeutic resistance.
authors.affiliation: Laboratory of Experimental Dermatology, Department of Dermatology and Allergy, University of Bonn, Bonn, Germany. Electronic address: Jenny.landsberg@ukb.uni-bonn.de.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Landsberg
authors.affiliation: Laboratory of Experimental Dermatology, Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Tüting
authors.affiliation: Department of Pathology, Institut Curie, and Université Paris Descartes, Paris, France; Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California, USA. Electronic address: raymond.barnhill@curie.fr.
authors.forename: Raymond L
authors.initials: RL
authors.lastname: Barnhill
authors.affiliation: Department of Pathology, Institut Curie, and Université Paris Descartes, Paris, France; Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Lugassy
mesh_terms: D000067558:Biological Mimicry / Q000502:physiology*; D001707:Biopsy, Needle; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000503:physiopathology*; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000503:physiopathology / Q000556:secondary; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D009504:Neutrophils / Q000166:cytology*; D020286:Pericytes / Q000166:cytology / Q000378:metabolism; D012380:Role; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000473:pathology* / Q000503:physiopathology
keywords: CAM; EVMM; NCC; chick chorioallantoic membrane assay; extravascular migratory metastasis; neural crest cell