title: Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer.
abstract: We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARRAY platform. The GA+AA genotype of ERCC2 rs1799793 showed significant and favorable response to chemotherapy than the wide-type GG genotype in multivariate analysis (OR = 1.78, 95%CI = 1.13-2.81). In a Cox proportional hazard model, carriers of ERCC2 rs1799793 GA+AA genotype exhibited longer duration of survival than did those with the GG genotype (hazards ratio = 0.57, 95%CI = 0.35-0.92). In conclusion, our study suggests that ERCC2 rs1799793 polymorphic variation could be used as a predictor for the prognosis of gastric cancer.
authors.affiliation: Department of Gastroenterology, The Second Hospital, Shandong University, Jinan, China.
authors.forename: W H
authors.initials: WH
authors.lastname: Yu
authors.affiliation: Department of Gastroenterology, The Second Hospital, Shandong University, Jinan, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, The Second Hospital, Shandong University, Jinan, China.
authors.forename: J Q
authors.initials: JQ
authors.lastname: Guo
authors.affiliation: Department of Pediatrics, The Second Hospital, Shandong University, Jinan, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Radiology, Shandong Cancer Hospital and Institute, Jinan, China.
authors.forename: J S
authors.initials: JS
authors.lastname: Zheng
authors.affiliation: Department of Gastroenterology, The Second Hospital, Shandong University, Jinan, China.
authors.forename: K X
authors.initials: KX
authors.lastname: Zhu
mesh_terms: D000368:Aged; D054316:Biomarkers, Pharmacological; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D016896:Treatment Outcome; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D054316:Biomarkers, Pharmacological; D004268:DNA-Binding Proteins; C071447:ERCC1 protein, human; D004720:Endonucleases; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human