title: Increased Dickkopf-1 in Recent-onset Rheumatoid Arthritis is a New Biomarker of Structural Severity. Data from the ESPOIR Cohort.
abstract: Rheumatoid arthritis (RA) is the most common chronic inflammatory rheumatic condition over the world. RA is potentially disabling because chronic inflammation of the joints leads to joint destruction. To date, the best predictor of radiographic progression for patients with early RA is the presence of radiographic erosions at baseline, but a limited number of predictive biomarkers of structural progression are currently used in daily practice. Here, we investigated Dickkopf-1 (DKK-1) and sclerostin (SOST) serum levels in patients with recent inflammatory arthritis from the ESPOIR cohort. This cohort is a prospective, multicenter French cohort of 813 patients with early arthritis. We observed that mean baseline DKK-1 level was higher among RA patients with than without radiological progression within the first 2 years of evolution. DKK-1 level was still associated with radiographic progression in a model including other main predictors of severity (erosions at baseline, and anti-CCP antibody positivity). This study demonstrates that increased DKK-1 level at baseline predicted structural progression after 2-year follow-up and suggests that DKK-1 might be a new structural biomarker for early RA.
authors.affiliation: Service de Rhumatologie-Hôpitaux Universitaires Paris Sud, Le Kremlin Bicêtre, France.|Unité INSERM U1012 - Université Paris Sud, Le Kremlin Bicêtre, France.
authors.forename: Raphaèle
authors.initials: R
authors.lastname: Seror
authors.affiliation: Unité INSERM U1012 - Université Paris Sud, Le Kremlin Bicêtre, France.
authors.forename: Saida
authors.initials: S
authors.lastname: Boudaoud
authors.affiliation: Service de Rhumatologie-Hôpitaux Universitaires Paris Sud, Le Kremlin Bicêtre, France.
authors.forename: Stephan
authors.initials: S
authors.lastname: Pavy
authors.affiliation: Service de Rhumatologie-Hôpitaux Universitaires Paris Sud, Le Kremlin Bicêtre, France.|Unité INSERM U1012 - Université Paris Sud, Le Kremlin Bicêtre, France.
authors.forename: Gaetane
authors.initials: G
authors.lastname: Nocturne
authors.affiliation: Groupe Hospitalier Pellegrin, Bordeaux, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Schaeverbeke
authors.affiliation: CHU de la Cavale Blanche, Brest Cedex, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Saraux
authors.affiliation: Assistance-Publique- Hôpitaux de Paris, Service d'Endocrinologie et des Maladies de la Reproduction, - Hôpitaux Universitaires Paris Sud, F-94275, Le Kremlin Bicêtre, France.|Univ Paris-Sud, UMR S693, F-94276, Le Kremlin Bicêtre, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Chanson
authors.affiliation: Service de Rhumatologie, Centre National de Référence pour les Maladies Auto-Immunes Systémiques Rares, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
authors.forename: Jacques-Eric
authors.initials: JE
authors.lastname: Gottenberg
authors.affiliation: CHU de la Cavale Blanche, Brest Cedex, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Devauchelle-Pensec
authors.affiliation: CHU de la Cavale Blanche, Brest Cedex, France.
authors.forename: Gabriel J
authors.initials: GJ
authors.lastname: Tobón
authors.affiliation: Service de Rhumatologie-Hôpitaux Universitaires Paris Sud, Le Kremlin Bicêtre, France.|Unité INSERM U1012 - Université Paris Sud, Le Kremlin Bicêtre, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Mariette
authors.affiliation: Service de Rhumatologie-Hôpitaux Universitaires Paris Sud, Le Kremlin Bicêtre, France.|Unité INSERM U1012 - Université Paris Sud, Le Kremlin Bicêtre, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Miceli-Richard
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins / Q000097:blood; D002097:C-Reactive Protein; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005819:Genetic Markers; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D007596:Joints / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; C501126:DKK1 protein, human; D005819:Genetic Markers; D036341:Intercellular Signaling Peptides and Proteins; C422903:SOST protein, human; D002097:C-Reactive Protein