title: Ocular Adnexal Acne Agminata: Histopathological and Clinical Case Series.
abstract: OBJECTIVE
  Acne agminata has only been rarely reported in the ocular adnexa. This study was undertaken to identify histopathological, clinical, and management features of this disorder.
  
  
  METHODS
  A computerized database was utilized to identify cases of ocular adnexal acne agminata. Via chart review and light microscopy, clinical and histopathologic aspects of this dermatosis were collected, and statistical analyses were performed.
  
  
  RESULTS
  Twelve cases (5 males, 7 females, mean age = 50.5 years) of clinically and histopathologically confirmed ocular adnexal acne agminata were identified. The main variant of granuloma was sarcoidal in 6 cases (50%) and tuberculoid in 5 cases (41.7%), although 9 specimens (75%) displayed greater than 1 variant of granuloma. In addition, specimens demonstrated varying degrees of fibrosis (8 cases, 66.7%), necrosis (6 cases, 50%), spongiosis (5 cases, 41.7%), and perifollicular inflammation (6 cases, 50%). All specimens showed signs of lymphstasis-lymphangiectasis. At a minimum of 6-month postprocedure interval, all patients experienced complete relief of their symptoms and did not experience recurrence.
  
  
  CONCLUSIONS
  This study represents the largest cohort of ocular adnexal acne agminata, and revealed a spectrum of granulomatous subtypes, including coexistence of different granuloma subtypes within the same specimen. Lymphangiectases is a hallmark of this disorder, and varying features of tissue reaction are typical features of acne agminata. All of these cases were successfully cured by surgical resection of lesions without recurrence at last follow-up, and this modality should be considered the standard of care in the management of this problem.
authors.affiliation: *Department of Ophthalmology, Albany Medical College, Albany, New York; †Division of Dermatology and Dermatopathology, Department of Pathology, Albany Medical College, Albany, New York; and ‡Ophthalmic Plastic Surgery, Department of Ophthalmology, Albany Medical College, Lions Eye Institute, Slingerlands, New York, U.S.A.
authors.forename: Rahul
authors.initials: R
authors.lastname: Raghu
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Carlson
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Wladis
mesh_terms: D017486:Acneiform Eruptions / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002675:Child, Preschool; D005141:Eyelid Diseases / Q000473:pathology*; D005260:Female; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000473:pathology*; D008200:Lymphangiectasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000473:pathology*