title: Evaluation of Efficacy and Safety of Latanoprost/Timolol versus Travoprost/Timolol Fixed Combinations for Ocular Hypertension Associated with Uveitis.
abstract: OBJECTIVE
  To compare latanoprost/timolol (LT) versus travoprost/timolol (TT) fixed combinations for ocular hypertension (OHT) associated with uveitis.
  
  
  METHODS
  Thirty-six patients (55 eyes) who were treated with LT (28 eyes) or TT (27 eyes) for OHT associated with uveitis were reviewed retrospectively. Intraocular pressure (IOP) and inflammation scores at the initiation of treatment and at the last visit during therapy were analyzed.
  
  
  RESULTS
  Although IOP was reduced significantly in both LT and TT groups, the reduction rate was significantly greater with TT group than with LT. The differences in the reduction of IOP between the groups remained significant when the cases were classified into inflammation-induced OHT and steroid-induced OHT. Inflammation score was not exacerbated by LT or TT treatment.
  
  
  CONCLUSIONS
  Both LT and TT are safe and effective for the treatment of OHT associated with uveitis and greater IOP reduction may be achieved by TT than by LT treatment.
authors.affiliation: a Department of Ophthalmology , National Defense Medical College , Tokorozawa, Saitama , Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: a Department of Ophthalmology , National Defense Medical College , Tokorozawa, Saitama , Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kanda
authors.affiliation: a Department of Ophthalmology , National Defense Medical College , Tokorozawa, Saitama , Japan.
authors.forename: Manzo
authors.initials: M
authors.lastname: Taguchi
authors.affiliation: a Department of Ophthalmology , National Defense Medical College , Tokorozawa, Saitama , Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Shibata
authors.affiliation: a Department of Ophthalmology , National Defense Medical College , Tokorozawa, Saitama , Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Mine
authors.affiliation: a Department of Ophthalmology , National Defense Medical College , Tokorozawa, Saitama , Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sakurai
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000209:etiology; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D013999:Timolol / Q000009:adverse effects / Q000627:therapeutic use*; D014065:Tonometry, Ocular; D000069557:Travoprost / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014605:Uveitis / Q000150:complications / Q000188:drug therapy*
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D013999:Timolol; D000069557:Travoprost
keywords: Ocular hypertension; prostaglandin (PG) analog; secondary glaucoma; uveitic glaucoma; uveitis; β-blocker