title: Fish collagen is an important panallergen in the Japanese population.
abstract: Collagen was identified as a fish allergen in early 2000s. Although its allergenic potential has been suggested to be low, risks associated with collagen as a fish allergen have not been evaluated to a greater extent. In this study, we aimed to clarify the importance of collagen as a fish allergen. Our results showed that 50% of Japanese patients with fish allergy had immunoglobulin E (IgE) against mackerel collagen, whereas 44% had IgE against mackerel parvalbumin. IgE inhibition assay revealed high cross-reactivity of mackerel collagen to 22 fish species (inhibition rates: 87-98%). Furthermore, a recently developed allergy test demonstrated that collagen triggered IgE cross-linking on mast cells. These data indicate that fish collagen is an important and very common panallergen in fish consumed in Japan. The high rate of individuals' collagen allergy may be attributable to the traditional Japanese custom of raw fish consumption.
authors.affiliation: Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo, Japan.|Course of Safety Management in Food Supply Chain, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Chemistry Division, Kanagawa Prefectural Institute of Public Health, Chigasaki-shi, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.affiliation: Course of Safety Management in Food Supply Chain, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Huge
authors.affiliation: Course of Safety Management in Food Supply Chain, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kubota
authors.affiliation: Department of Dermatology, National Defense Medical College, Tokorozawa-shi, Saitama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Chikazawa
authors.affiliation: Department of Dermatology, National Defense Medical College, Tokorozawa-shi, Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.affiliation: Department of Dermatology, Shinshu University Hospital, Matsumoto-shi, Nagano, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyake
authors.affiliation: Department of Dermatology, Shinshu University Hospital, Matsumoto-shi, Nagano, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Uhara
authors.affiliation: Department of Dermatology, Shinshu University Hospital, Matsumoto-shi, Nagano, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Okuyama
authors.affiliation: Department of Dermatology, Yokohama City University School of Medicine, Yokohama-shi, Kanagawa, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Nakagawara
authors.affiliation: Department of Dermatology, Yokohama City University School of Medicine, Yokohama-shi, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Aihara
authors.affiliation: Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo, Japan.|Course of Safety Management in Food Supply Chain, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hamada-Sato
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D003094:Collagen / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D005399:Fishes / Q000276:immunology*; D005512:Food Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007564:Japan / Q000453:epidemiology; D011159:Population Surveillance
chemical_list: D000485:Allergens; D000939:Epitopes; D007073:Immunoglobulin E; D003094:Collagen
keywords: collagen; cross-reactivity; immunoglobulin E; mast cell; parvalbumin