title: Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.
abstract: The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer risk (pooled OR = 0.78; 95%CI: 0.73-0.83). The results of linear and nonlinear dose-response analysis indicated that high serum/plasma selenium and toenail selenium had the efficacy on cancer prevention. However, we did not find a protective efficacy of selenium supplement. High selenium exposure may have different effects on specific types of cancer. It decreased the risk of breast cancer, lung cancer, esophageal cancer, gastric cancer, and prostate cancer, but it was not associated with colorectal cancer, bladder cancer, and skin cancer.
authors.affiliation: Institute of Environmental Medicine, Zhejiang University, P.R.China.|Ningbo Medical Treatment Center Lihuili Hospital, P.R.China.
authors.forename: Xianlei
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Clinic Medicine, Zhejiang University, Hangzhou, P.R.China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Epidemiology &Biostatistics, Zhejiang University, Hangzhou, P.R.China.
authors.forename: Wanqi
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Epidemiology &Biostatistics, Zhejiang University, Hangzhou, P.R.China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Fan
authors.affiliation: Department of Epidemiology &Biostatistics, Zhejiang University, Hangzhou, P.R.China.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Clinic Medicine, Zhejiang University, Hangzhou, P.R.China.
authors.forename: Ning
authors.initials: N
authors.lastname: Shen
authors.affiliation: Department of Clinic Medicine, Zhejiang University, Hangzhou, P.R.China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Wu
authors.affiliation: Institute of Environmental Medicine, Zhejiang University, P.R.China.|Department of Epidemiology &Biostatistics, Zhejiang University, Hangzhou, P.R.China.
authors.forename: Xiuyang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Toxicology &Nutrition, Zhejiang University, Hangzhou, P.R.China.
authors.forename: Fudi
authors.initials: F
authors.lastname: Wang
mesh_terms: D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D009262:Nails / Q000737:chemistry; D009369:Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000209:etiology*; D016017:Odds Ratio; D018570:Risk Assessment; D012643:Selenium / Q000009:adverse effects*
chemical_list: D012643:Selenium