title: Ca(2+) microdomains, NAADP and type 1 ryanodine receptor in cell activation.
abstract: Nicotinic acid adenine dinucleotide phosphate (NAADP) is a Ca(2+) mobilizing second messenger that belongs to the superfamily of regulatory adenine nucleotides. Though NAADP has been known since 20 years, several aspects of its metabolism and molecular mode of action are still under discussion. Though the importance of the type 1 ryanodine receptor was discovered and published already in 2002 Hohenegger et al. (2002 Oct 15), recent data re-emphasize these original findings in pancreatic acinar cells and in T-lymphocytes. Here we review recent developments in NAADP formation and metabolism, putative target Ca(2+) channels for NAADP with special emphasis on the type 1 ryanodine receptor, and NAADP binding proteins. The latter are basis for a unifying hypothesis for NAADP action. Finally, the role of NAADP in T cell Ca(2+) signaling and activation is discussed. This article is part of a Special Issue entitled: Calcium and Cell Fate. Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen.
authors.affiliation: The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. Electronic address: guse@uke.de.
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Guse
authors.affiliation: The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
authors.forename: Insa M A
authors.initials: IM
authors.lastname: Wolf
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D006801:Humans; D008213:Lymphocyte Activation; D021962:Membrane Microdomains / Q000378:metabolism*; D008954:Models, Biological; D009249:NADP / Q000031:analogs & derivatives* / Q000378:metabolism; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D009249:NADP; C024376:NAADP; D002118:Calcium
keywords: NAADP; Ryanodine receptor; Signal transduction; T cell