title: Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide.
abstract: Imaging hydrogen sulfide (H2S) at the subcellular resolution will greatly improve the understanding of functions of this signaling molecule. Taking advantage of the protein labeling technologies, we report a general strategy for the development of organelle specific H2S probes, which enables sub-cellular H2S imaging essentially in any organelles of interest.
authors.affiliation: Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, U.S.A.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Chen
authors.affiliation: Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX 77030, U.S.A.
authors.forename: Mingkun
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, U.S.A.
authors.forename: Xiqian
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, U.S.A.
authors.forename: Antons
authors.initials: A
authors.lastname: Sizovs
authors.affiliation: Department of Molecular and Human Genetics and Huffington Centre on Aging, Baylor College of Medicine, Houston, TX 77030, U.S.A.
authors.forename: Meng C
authors.initials: MC
authors.lastname: Wang
authors.affiliation: New England Biolabs, Ipswich, MA 01938, U.S.A.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Provost
authors.affiliation: Sciclotron LLC., Sugar Land, TX 77479, U.S.A.
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, U.S.A.|Centre for Drug Discovery, Dan L. Duncan Cancer Centre, and Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, U.S.A.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
mesh_terms: D005821:Genetic Techniques; D006367:HeLa Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D042541:Intracellular Space / Q000378:metabolism*; D008164:Luminescent Proteins / Q000235:genetics* / Q000378:metabolism*; D057054:Molecular Imaging / Q000379:methods*
chemical_list: D008164:Luminescent Proteins; D006862:Hydrogen Sulfide