title: SOS response and its regulation on the fluoroquinolone resistance.
abstract: Bacteria can survive fluoroquinolone antibiotics (FQs) treatment by becoming resistant through a genetic change-mutation or gene acquisition. The SOS response is widespread among bacteria and exhibits considerable variation in its composition and regulation, which is repressed by LexA protein and derepressed by RecA protein. Here, we take a comprehensive review of the SOS gene network and its regulation on the fluoroquinolone resistance. As a unique survival mechanism, SOS may be an important factor influencing the outcome of antibiotic therapy in vivo.
authors.affiliation: 1 Medical Technology Institute of Xuzhou Medical College, Xuzhou 221004, China ; 2 Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Qin
authors.affiliation: 1 Medical Technology Institute of Xuzhou Medical College, Xuzhou 221004, China ; 2 Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China.
authors.forename: Hai-Quan
authors.initials: HQ
authors.lastname: Kang
authors.affiliation: 1 Medical Technology Institute of Xuzhou Medical College, Xuzhou 221004, China ; 2 Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ma
authors.affiliation: 1 Medical Technology Institute of Xuzhou Medical College, Xuzhou 221004, China ; 2 Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China.
authors.forename: Peng-Peng
authors.initials: PP
authors.lastname: Li
authors.affiliation: 1 Medical Technology Institute of Xuzhou Medical College, Xuzhou 221004, China ; 2 Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China.
authors.forename: Lin-Yan
authors.initials: LY
authors.lastname: Huang
authors.affiliation: 1 Medical Technology Institute of Xuzhou Medical College, Xuzhou 221004, China ; 2 Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Gu
keywords: Fluoroquinolone resistance; SOS response; regulation