title: Activation of TRAIL-DR5 pathway promotes sensorineural degeneration in the inner ear.
abstract: Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF-α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF-related apoptosis-inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5-blocking antibodies.
authors.affiliation: Eaton Peabody Laboratories and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
authors.forename: Shyan-Yuan
authors.initials: SY
authors.lastname: Kao
authors.affiliation: Eaton Peabody Laboratories and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.|Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA.
authors.forename: Vitor Y R
authors.initials: VY
authors.lastname: Soares
authors.affiliation: Eaton Peabody Laboratories and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
authors.forename: Arthur G
authors.initials: AG
authors.lastname: Kristiansen
authors.affiliation: Eaton Peabody Laboratories and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.|Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA.|Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, Boston, MA, USA.
authors.forename: Konstantina M
authors.initials: KM
authors.lastname: Stankovic
mesh_terms: D000818:Animals; D003051:Cochlea / Q000378:metabolism / Q000473:pathology; D007758:Ear, Inner / Q000378:metabolism / Q000473:pathology; D006199:Hair Cells, Auditory, Inner / Q000378:metabolism* / Q000473:pathology; D006319:Hearing Loss, Sensorineural / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008810:Mice, Inbred C57BL; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000096:biosynthesis / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology; D015398:Signal Transduction; D013136:Spiral Ganglion / Q000378:metabolism / Q000473:pathology; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D011994:Recombinant Proteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505654:Tnfsf10 protein, mouse
keywords: DR5; OPG; TRAIL; cochlea; hair cells; spiral ganglion neuron