title: Implemented myeloma management with whole-body low-dose CT scan: a real life experience.
abstract: A total of 318 consecutive myeloma patients underwent whole-body low-dose CT scan (WBLDCT) at baseline and during follow-up as a radiological assessment of lytic lesions in place of skeletal X-ray survey. After WBLDCT baseline assessment, 60% had bone involvement. The presence of lytic lesions represented the only met CRAB (hyperCalcaemia, Renal insufficiency, Anaemia, Bone lesions) criteria in 29% of patients. Patients presenting with extramedullary masses were 10%. Radiological progression was documented in 9% of the population with available follow-up. Additional pathological incidental findings were detected in 28 patients (14.5%), most located in the chest region (68%). In conclusion, our real-life data shows that WBLDCT scan represents a reliable imaging tool for decision-making process for multiple myeloma management in different disease phases, providing significant additional information on the presence of soft tissues plasmacytomas detection as well as the presence of pathological incidental findings.
authors.affiliation: a Division of Hematology , Fondazione IRCCS Policlinico San Matteo , Pavia , Italy ;
authors.forename: Silvia
authors.initials: S
authors.lastname: Mangiacavalli
authors.affiliation: b Division of Hematology , Ospedale San Gerardo - Università Degli Studi Milano Bicocca , Monza , Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Pezzatti
authors.affiliation: b Division of Hematology , Ospedale San Gerardo - Università Degli Studi Milano Bicocca , Monza , Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Rossini
authors.affiliation: b Division of Hematology , Ospedale San Gerardo - Università Degli Studi Milano Bicocca , Monza , Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Doni
authors.affiliation: a Division of Hematology , Fondazione IRCCS Policlinico San Matteo , Pavia , Italy ;
authors.forename: Federica
authors.initials: F
authors.lastname: Cocito
authors.affiliation: b Division of Hematology , Ospedale San Gerardo - Università Degli Studi Milano Bicocca , Monza , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bolis
authors.affiliation: a Division of Hematology , Fondazione IRCCS Policlinico San Matteo , Pavia , Italy ;
authors.forename: Alessandro
authors.initials: A
authors.lastname: Corso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058070:Asymptomatic Diseases; D015415:Biomarkers; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis*; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D011829:Radiation Dosage; D063189:Symptom Assessment; D014057:Tomography, X-Ray Computed / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: Bone disease; multiple myeloma; whole body low-dose computed tomography