title: Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models.
abstract: Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.
authors.affiliation: INRA, Commensal and Probiotics-Host Interactions Laboratory, UMR 1319 Micalis, F-78350 Jouy-en-Josas, France.|AgroParisTech, UMR1319 Micalis, F-78350 Jouy-en-Josas, France.|Laboratoire Microorganismes: Génome et Environnement, UMR CNRS 6023, 63000 Clermont-Ferrand, France.|Université d'Auvergne, 63000, Clermont-Ferrand, France.
authors.forename: S
authors.initials: S
authors.lastname: Miquel
authors.affiliation: INRA, Commensal and Probiotics-Host Interactions Laboratory, UMR 1319 Micalis, F-78350 Jouy-en-Josas, France.|AgroParisTech, UMR1319 Micalis, F-78350 Jouy-en-Josas, France.
authors.forename: R
authors.initials: R
authors.lastname: Martín
authors.affiliation: Université d'Auvergne, 63000, Clermont-Ferrand, France.|INSERM 1107 Neuro-Dol, 630000 Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Lashermes
authors.affiliation: Neuro-Gastroenterology and Nutrition Team, TOXALIM, UMR 1331-INRA/INP/UPS, F-31931 Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Gillet
authors.affiliation: Université d'Auvergne, 63000, Clermont-Ferrand, France.|INSERM 1107 Neuro-Dol, 630000 Clermont-Ferrand, France.
authors.forename: M
authors.initials: M
authors.lastname: Meleine
authors.affiliation: Université d'Auvergne, 63000, Clermont-Ferrand, France.|INSERM 1107 Neuro-Dol, 630000 Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Gelot
authors.affiliation: Université d'Auvergne, 63000, Clermont-Ferrand, France.|INSERM 1107 Neuro-Dol, 630000 Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Eschalier
authors.affiliation: Université d'Auvergne, 63000, Clermont-Ferrand, France.|INSERM 1107 Neuro-Dol, 630000 Clermont-Ferrand, France.
authors.forename: D
authors.initials: D
authors.lastname: Ardid
authors.affiliation: INRA, Commensal and Probiotics-Host Interactions Laboratory, UMR 1319 Micalis, F-78350 Jouy-en-Josas, France.|AgroParisTech, UMR1319 Micalis, F-78350 Jouy-en-Josas, France.
authors.forename: L G
authors.initials: LG
authors.lastname: Bermúdez-Humarán
authors.affiliation: INRA, Commensal and Probiotics-Host Interactions Laboratory, UMR 1319 Micalis, F-78350 Jouy-en-Josas, France.|AgroParisTech, UMR1319 Micalis, F-78350 Jouy-en-Josas, France.|APHP, Hôpital Saint Antoine - Service de Gastroentérologie et nutrition, F-75012 Paris, France.|Sorbonne Universités, UPMC Univ Paris 06, LBM, 27 rue de Chaligny, F-75012 Paris, France.|INSERM-ERL 1157 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), CHU Saint-Antoine 27 rue de Chaligny, F-75012 Paris, France.|CNRS, UMR 7203 LBM, F-75005 Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Sokol
authors.affiliation: INRA, Commensal and Probiotics-Host Interactions Laboratory, UMR 1319 Micalis, F-78350 Jouy-en-Josas, France.|AgroParisTech, UMR1319 Micalis, F-78350 Jouy-en-Josas, France.
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.affiliation: Neuro-Gastroenterology and Nutrition Team, TOXALIM, UMR 1331-INRA/INP/UPS, F-31931 Toulouse, France.
authors.forename: V
authors.initials: V
authors.lastname: Theodorou
authors.affiliation: INRA, Commensal and Probiotics-Host Interactions Laboratory, UMR 1319 Micalis, F-78350 Jouy-en-Josas, France.|AgroParisTech, UMR1319 Micalis, F-78350 Jouy-en-Josas, France.
authors.forename: P
authors.initials: P
authors.lastname: Langella
authors.affiliation: Université d'Auvergne, 63000, Clermont-Ferrand, France.|INSERM 1107 Neuro-Dol, 630000 Clermont-Ferrand, France.
authors.forename: F A
authors.initials: FA
authors.lastname: Carvalho
mesh_terms: D000818:Animals; D003106:Colon / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D004195:Disease Models, Animal; D000070037:Faecalibacterium prausnitzii / Q000502:physiology*; D007413:Intestinal Mucosa; D043183:Irritable Bowel Syndrome / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology; D008297:Male; D008426:Maternal Deprivation; D051379:Mice; D010539:Permeability; D013312:Stress, Physiological