title: The Role of Positron Emission Tomography With (68)Gallium (Ga)-Labeled Prostate-specific Membrane Antigen (PSMA) in the Management of Patients With Organ-confined and Locally Advanced Prostate Cancer Prior to Radical Treatment and After Radical Prostatectomy.
abstract: The role of positron emission tomography (PET) with (68)Gallium (Ga)-labeled prostate-specific membrane antigen (PSMA) imaging for prostate cancer is gaining prominence. Current imaging strategies, despite having progressed significantly, have limitations, in particular their ability to diagnose metastatic lymph node involvement. Preliminary results of PET with (68)Ga-labeled PSMA have shown encouraging results, particularly in the recurrent prostate cancer setting. Furthermore, the ability of PET with (68)Ga-labeled PSMA of playing a dual diagnostic and therapeutic setting (theranostics) is currently being investigated as well. PET with (68)Ga-labeled PSMA certainly has a role to play in bridging some of the voids in contemporary prostate cancer imaging tools.
authors.affiliation: Hertfordshire and South Bedfordshire Urological Cancer Centre, Department of Urology, Lister Hospital, Stevenage, United Kingdom. Electronic address: urobhavan@gmail.com.
authors.forename: Bhavan Prasad
authors.initials: BP
authors.lastname: Rai
authors.affiliation: Department of Nuclear Medicine, Center for PET/CT, Zentralklinik Bad Berka, ENETS Center of Excellence, Bad Berka, Germany.
authors.forename: Richard Paul
authors.initials: RP
authors.lastname: Baum
authors.affiliation: Department of Radiology, Lister Hospital, Stevenage, United Kingdom.
authors.forename: Amit
authors.initials: A
authors.lastname: Patel
authors.affiliation: Department of Oncology, Mount Vernon Cancer Centre, United Kingdom.
authors.forename: Robert
authors.initials: R
authors.lastname: Hughes
authors.affiliation: Department of Oncology, Mount Vernon Cancer Centre, United Kingdom.
authors.forename: Roberto
authors.initials: R
authors.lastname: Alonzi
authors.affiliation: Hertfordshire and South Bedfordshire Urological Cancer Centre, Department of Urology, Lister Hospital, Stevenage, United Kingdom.
authors.forename: Tim
authors.initials: T
authors.lastname: Lane
authors.affiliation: Hertfordshire and South Bedfordshire Urological Cancer Centre, Department of Urology, Lister Hospital, Stevenage, United Kingdom.
authors.forename: Jim
authors.initials: J
authors.lastname: Adshead
authors.affiliation: Hertfordshire and South Bedfordshire Urological Cancer Centre, Department of Urology, Lister Hospital, Stevenage, United Kingdom.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Vasdev
mesh_terms: D000954:Antigens, Surface; D005710:Gallium Radioisotopes; D043425:Glutamate Carboxypeptidase II; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D011300:Preoperative Care; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*
chemical_list: D000954:Antigens, Surface; D005710:Gallium Radioisotopes; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II