title: Neurocutaneous disease: Cutaneous neuroanatomy and mechanisms of itch and pain.
abstract: Few sources of information exist regarding cutaneous innervation and how to apply this basic neurologic science to the clinical treatment of itch, as often performed on a daily basis by dermatologists. We address the types of nerve fibers that innervate the skin and their different components and discuss the similarities and differences between itch and pain. We hope that increased knowledge of this topic will improve the recognition and treatment of neuropathic itch.
authors.affiliation: Department of Neurology, University of Missouri, Columbia, Missouri.
authors.forename: Miguel
authors.initials: M
authors.lastname: Chuquilin
authors.affiliation: School of Medicine, University of Missouri, Columbia, Missouri.
authors.forename: Yazan
authors.initials: Y
authors.lastname: Alghalith
authors.affiliation: Department of Dermatology, University of Missouri, Columbia, Missouri. Electronic address: fernandezk@health.missouri.edu.
authors.forename: Kristen Heins
authors.initials: KH
authors.lastname: Fernandez
mesh_terms: D000701:Analgesics, Opioid / Q000378:metabolism; D000818:Animals; D019703:Calcineurin / Q000378:metabolism; D006632:Histamine / Q000378:metabolism; D006801:Humans; D009434:Neural Pathways; D010146:Pain / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D011537:Pruritus / Q000188:drug therapy* / Q000378:metabolism*; D015398:Signal Transduction; D012867:Skin / Q000294:innervation* / Q000378:metabolism*; D012879:Skin Physiological Phenomena; D050916:TRPV Cation Channels / Q000378:metabolism
chemical_list: D000701:Analgesics, Opioid; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D006632:Histamine; D019703:Calcineurin; D010447:Peptide Hydrolases
keywords: cutaneous innervation; itch; nerve fibers; neuroanatomy; pain; pruritogens