title: The multifaceted role of CD4(+) T cells in CD8(+) T cell memory.
abstract: Following infection, T cells differentiate into a heterogeneous population of effector T cells that can mediate pathogen clearance. A subset of these effector T cells possesses the ability to survive long term and mature into memory T cells that can provide long-term immunity. Understanding the signals that regulate the development of memory T cells is crucial to efforts to design vaccines capable of eliciting T cell-based immunity. CD4(+) T cells are essential in the formation of protective memory CD8(+) T cells following infection or immunization. However, until recently, the mechanisms by which CD4(+) T cells act to support memory CD8(+) T cell development following infection were unclear. Here, we discuss recent studies that provide insight into the multifaceted role of CD4(+) T cells in the regulation of memory CD8(+) T cell differentiation.
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.|Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California 94143, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Laidlaw
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.|Department of Internal Medicine (Rheumatology), Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Craft
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.|Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 2081, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Kaech
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007156:Immunologic Memory / Q000276:immunology*; D007239:Infections / Q000276:immunology*; D014611:Vaccination