title: Acute kidney stress--a useful term based on evolution in the understanding of acute kidney injury.
abstract: Critical care physicians have debated an appropriate term for the clinical phase preceding acute kidney injury (AKI). The recent development of cell cycle arrest biomarkers that signal the potential development of AKI is part of an evolution in the molecular diagnosis and understanding of AKI. It is proposed that the pre-injury phase that leads to AKI can be described as "acute kidney stress". This term has the potential to expand horizons in regard to the early detection of situations that will lead to AKI and the early implementation of corrective measures.
authors.affiliation: Division of Cardiac Surgery, Johns Hopkins University, 1800 Orleans Street, Suite 7107, Baltimore, MD, 21287, USA. nevinkatz@aol.com.|Foundation for the Advancement of Cardiothoracic Surgical Care (FACTS-Care), 1912 Foxhall Road, McLean, VA, 22101, USA. nevinkatz@aol.com.
authors.forename: Nevin
authors.initials: N
authors.lastname: Katz
authors.affiliation: Department of Nephrology, Dialysis and Renal Transplantation, International Renal Research Institute Vicenza (IRRIV), San Bortolo Hospital, Vicenza, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
mesh_terms: D058186:Acute Kidney Injury / Q000145:classification* / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D002985:Clinical Protocols / Q000145:classification; D006801:Humans; D007668:Kidney / Q000378:metabolism*
chemical_list: D015415:Biomarkers