title: How we diagnose and treat neutropenia in adults.
abstract: Neutropenias (NPs), being acute and often transient, or chronic, range from life-threatening conditions with very low absolute neutrophil blood counts (ANC) to disorders characterized by only mild NP and of no obvious significance for health. Many are caused by genetic variations/mutations, e.g. the benign familial NP and the chronic severe NPs (e.g. Kostmann disease). Some of the latter are associated with various bodily malformations. Many of the mild-to-moderate NPs are signs of underlying disorders that need specialized treatments (e.g. HIV, hepatitis, autoimmune disorders, the large granular lymphocyte syndrome). We provide here means for the evaluation of a previously unknown NP, suggest a triage and treatments.
authors.affiliation: a Departments of Medicine and Hematology , The Karolinska Institutet, Karolinska University Hospital Huddinge , Stockholm , Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Palmblad
authors.affiliation: a Departments of Medicine and Hematology , The Karolinska Institutet, Karolinska University Hospital Huddinge , Stockholm , Sweden.
authors.forename: Christer C
authors.initials: CC
authors.lastname: Nilsson
authors.affiliation: b Center for Hematology and Regenerative Medicine (HERM), Departments of Hematology and Clinical Immunology and Transfusion Medicine , Karolinska University Hospital Huddinge , Stockholm , Sweden.
authors.forename: Petter
authors.initials: P
authors.lastname: Höglund
authors.affiliation: c Department of Hematology , University of Crete Medical School , Heraklion , Greece.
authors.forename: Helen A
authors.initials: HA
authors.lastname: Papadaki
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000465:Algorithms; D002908:Chronic Disease; D019468:Disease Management; D006801:Humans; D009503:Neutropenia / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D011379:Prognosis; D012720:Severity of Illness Index
keywords: G-CSF; Neutropenia; adverse drug reactions; agranulocytosis; autoimmune neutropenia; idiopathic neutropenia; large granular lymphocytosis; plerixafor; severe chronic neutropenia