title: An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival.
abstract: Apoptosis resistance is a hallmark of human cancer, and tumor cells often become resistant due to defects in the programmed cell death machinery. Targeting key apoptosis regulators to overcome apoptotic resistance and promote rapid death of tumor cells is an exciting new strategy for cancer treatment, either alone or in combination with traditionally used anti-cancer drugs that target cell division. Here we present a multiscale modeling framework for investigating the synergism between traditional chemotherapy and targeted therapies aimed at critical regulators of apoptosis.
authors.affiliation: Department of Applied Mathematics, Brown University, 182 George Street, Providence, RI 02906, United States email: alexis_cook@brown.edu.
authors.forename: Alexis B
authors.initials: AB
authors.lastname: Cook
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Ziazadeh
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Lu
authors.forename: Trachette L
authors.initials: TL
authors.lastname: Jackson
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002945:Cisplatin / Q000493:pharmacokinetics / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D006801:Humans; D055641:Mathematical Concepts; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors; D051020:bcl-X Protein / Q000037:antagonists & inhibitors
chemical_list: D000970:Antineoplastic Agents; C494811:BCL2L1 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D051020:bcl-X Protein; D002945:Cisplatin