title: SQ house dust mite (HDM) SLIT-tablet provides clinical improvement in HDM-induced allergic rhinitis.
abstract: House dust mite (HDM) allergy represents a highly prevalent inhalant allergy, and exposure to HDM allergens results in allergic rhinitis with persistent symptoms that may not be adequately controlled with available allergy pharmacotherapy. Allergy immunotherapy constitutes a complementary treatment option targeting the underlying immunological mechanisms of allergic disease and represents the only treatment with a potential for disease modification and long-term efficacy. As traditional allergy immunotherapy delivered by subcutaneous injection of specific HDM allergens involves a time-consuming treatment regimen and a risk of systemic adverse reactions, sublingually administered allergy immunotherapy (SLIT) has been investigated as a more convenient treatment option with similar levels of efficacy and an improved safety profile that allows for at-home daily administration. In this Drug Profile, we provide a review of the clinical data behind the SQ HDM SLIT-tablet, which was recently approved for the treatment of HDM-induced allergic rhinitis by regulatory authorities in Europe and Japan.
authors.affiliation: a Center for Rhinology and Allergology , Wiesbaden , Germany.
authors.forename: Ludger
authors.initials: L
authors.lastname: Klimek
authors.affiliation: b Allergy Clinic , Copenhagen University Hospital Gentofte , Hellerup , Denmark.
authors.forename: Holger
authors.initials: H
authors.lastname: Mosbech
authors.affiliation: c Vienna Challenge Chamber , Allergy Center Vienna West , Vienna , Austria.
authors.forename: Petra
authors.initials: P
authors.lastname: Zieglmayer
authors.affiliation: d Global Clinical Development, ALK , Hoersholm , Denmark.
authors.forename: Dorte
authors.initials: D
authors.lastname: Rehm
authors.affiliation: d Global Clinical Development, ALK , Hoersholm , Denmark.
authors.forename: Brian Sonne
authors.initials: BS
authors.lastname: Stage
authors.affiliation: e Department of Pulmonology, Division of Allergy, Hôpital Arnaud de Villeneuve , University Hospital of Montpellier , Montpellier , France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Demoly
mesh_terms: D000286:Administration, Sublingual; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D003888:Desensitization, Immunologic; D006801:Humans; D039981:Pyroglyphidae / Q000276:immunology; D065631:Rhinitis, Allergic / Q000276:immunology / Q000628:therapy*; D013607:Tablets
chemical_list: D039741:Antigens, Dermatophagoides; D013607:Tablets
keywords: House dust mite; SLIT-tablet; allergic rhinitis; allergy immunotherapy; sublingual immunotherapy