title: Docetaxel/Cyclophosphamide-Induced Phototherapy Recall.
abstract: Phototherapy recall can occur unexpectedly as a result of treatment with commonly used medications and chemotherapy. These reactions are rare. The recall reaction is an inflammatory response that is triggered by many medications. Cyclophosphamide and docetaxel are widely used chemotherapeutic agents that are useful in the management of many different malignancies. The pathophysiology of phototherapy recall is not clearly understood. This case highlights the need for practitioners to be aware of this potential reaction, even though UV exposure may have occurred in the distant past. We present, to the best of our knowledge, the first phototherapy recall dermatitis that occurred years after UV exposure induced by cyclophosphamide and docetaxel. The frequency of administration of this drug and the profound implications of this adverse effect make this case an important contribution to the medical literature.
authors.affiliation: Department of Pharmacy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA steven.ludlow@moffitt.org.
authors.forename: Steven P
authors.initials: SP
authors.lastname: Ludlow
authors.affiliation: Department of Pharmacy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Chehab
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D003520:Cyclophosphamide / Q000009:adverse effects*; D000077143:Docetaxel; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D010789:Phototherapy / Q000009:adverse effects*; D011855:Radiodermatitis / Q000139:chemically induced*; D043823:Taxoids / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D003520:Cyclophosphamide
keywords: cyclophosphamide; docetaxel; phototherapy recall