title: Molecular control of fission yeast cytokinesis.
abstract: Cytokinesis gives rise to two independent daughter cells at the end of the cell division cycle. The fission yeast Schizosaccharomyces pombe has emerged as one of the most powerful systems to understand how cytokinesis is controlled molecularly. Like in most eukaryotes, fission yeast cytokinesis depends on an acto-myosin based contractile ring that assembles at the division site under the control of spatial cues that integrate information on cell geometry and the position of the mitotic apparatus. Cytokinetic events are also tightly coordinated with nuclear division by the cell cycle machinery. These spatial and temporal regulations ensure an equal cleavage of the cytoplasm and an accurate segregation of the genetic material in daughter cells. Although this model system has specificities, the basic mechanisms of contractile ring assembly and function deciphered in fission yeast are highly valuable to understand how cytokinesis is controlled in other organisms that rely on a contractile ring for cell division.
authors.affiliation: Institut Curie, Centre de Recherche, PSL Research University, F-75248 Paris, France; CNRS UMR144, F-75248 Paris, France.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Rincon
authors.affiliation: Institut Curie, Centre de Recherche, PSL Research University, F-75248 Paris, France; CNRS UMR144, F-75248 Paris, France. Electronic address: anne.paoletti@curie.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Paoletti
mesh_terms: D048749:Cytokinesis; D008954:Models, Biological; D012568:Schizosaccharomyces / Q000166:cytology*