title: Regulation of class IIa HDAC activities: it is not only matter of subcellular localization.
abstract: In response to environmental cues, enzymes that influence the functions of proteins, through reversible post-translational modifications supervise the coordination of cell behavior like orchestral conductors. Class IIa histone deacetylases (HDACs) belong to this category. Even though in vertebrates these deacetylases have discarded the core enzymatic activity, class IIa HDACs can assemble into multiprotein complexes devoted to transcriptional reprogramming, including but not limited to epigenetic changes. Class IIa HDACs are subjected to variegated and interconnected layers of regulation, which reflect the wide range of biological responses under the scrutiny of this gene family. Here, we discuss about the key mechanisms that fine tune class IIa HDACs activities.
authors.affiliation: Department of Medical & Biological Sciences, Università degli Studi di Udine., P.le Kolbe 4 - 33100 Udine, Italy.
authors.forename: Eros
authors.initials: E
authors.lastname: Di Giorgio
authors.affiliation: Department of Medical & Biological Sciences, Università degli Studi di Udine., P.le Kolbe 4 - 33100 Udine, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Brancolini
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D016678:Genome; D006655:Histone Deacetylases / Q000145:classification* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D021381:Protein Transport; D059748:Proteolysis; D034622:RNA Interference; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger; D011494:Protein Kinases; D006655:Histone Deacetylases; D002118:Calcium
keywords: AMPK; FOXO; HDAC4; HDAC5; HDAC7; HDAC9; LKB; MEF2; PKD; SIK