title: Serum endothelial cell specific molecule-1 (endocan) levels in patients with obstructive sleep apnea.
abstract: OBJECTIVE
  To investigate the level of endothelial cell specific molecule-1 (endocan) in obstructive sleep apnea (OSA).
  
  
  METHODS
  Study group included subjects with OSA. Control group included subjects who had no OSA on polysomnography and nonobese healthy subjects from population who had no OSA symptoms. Endocan levels of OSA and non-OSA subjects were compared.
  
  
  RESULTS
  Totally 106 individuals (63 OSA, 43 non-OSA) were included. Endocan levels were higher in OSA subjects than controls (1.25 ± 0.4 ng/ml vs 0.93 ± 0.3 ng/ml, p < 0.001). Endocan levels were correlated with BMI (r = 0.456, p < 0.001) and daytime PaO2 (r = -0.266, p < 0.042). In linear regression analysis there was no factor related to endocan level.
  
  
  CONCLUSIONS
  Serum endocan is significantly higher in OSA. Further studies should be performed to better understand the relationship between endocan and OSA.
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Pulmonary Medicine, 34360, Istanbul, Turkey.
authors.forename: Zuleyha
authors.initials: Z
authors.lastname: Bingol
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, 34360, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kose
authors.affiliation: Istanbul Haydarpasa Numune Training and Research Hospital, Department of Pulmonary Medicine, 34668, Istanbul, Turkey.
authors.forename: Aylin
authors.initials: A
authors.lastname: Pıhtılı
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, 34360, Istanbul, Turkey.
authors.forename: Timur
authors.initials: T
authors.lastname: Akpınar
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, 34360, Istanbul, Turkey.
authors.forename: Tufan
authors.initials: T
authors.lastname: Tukek
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Pulmonary Medicine, 34360, Istanbul, Turkey.|Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, 34360, Istanbul, Turkey.
authors.forename: Esen
authors.initials: E
authors.lastname: Kıyan
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000097:blood; D000860:Hypoxia / Q000097:blood; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D017286:Polysomnography; D011446:Prospective Studies; D011509:Proteoglycans / Q000097:blood*; D012044:Regression Analysis; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans
keywords: endocan; endothelial cell-specific molecule-1; endothelial dysfunction; obstructive sleep apnea