title: The diagnostic value of two commercially available human cTnI assays in goat kids with myocarditis.
abstract: BACKGROUND
  Cardiac troponin I (cTnI) is a peripheral blood marker for myocardial damage. Because of the unavailability of goat-specific cTnI assays human cTnI assays may be validated for detection of myocarditis in goat kids.
  
  
  OBJECTIVE
  The purpose of the study was to evaluate 2 commercially available human cTnI assays in goat kids with myocardial damage, and to determine the cTnI expression in cardiac muscle.
  
  
  METHODS
  Plasma cTnI concentrations were measured in healthy goat kids (n = 7) and goat kids with myocardial damage (n = 8) using the Beckman Coulter Access Accu TnI and the Biomérieux Vidas Ultra. The results were correlated with gross necropsy and histopathologic findings, and cTnI immunhistochemistry in cardiac tissue.
  
  
  RESULTS
  Macro- and microscopic findings confirmed myocardial damage in the myocarditis group. Mean plasma cTnI concentration was significantly higher in the myocarditis group than in the healthy control group (104.82 vs 0.02 ng/mL). The overall mean plasma cTnI concentration measured by Biomérieux Vidas Ultra (61.75 ng/mL, 95% CI: 19.55-103.95) was comparable to the mean measured by Beckman Coulter Access Accu TnI (50.08 ng/mL, 95% CI: 24.11-76.06), and cTnI concentrations measured by these assays were highly correlated (r = .977) with a -6.2% bias. Both assays were precise and accurate.
  
  
  CONCLUSIONS
  The human-specific Beckman Coulter Access Accu TnI and the Biomérieux Vidas Ultra can be used for diagnostic confirmation of myocardial damage in caprine medicine.
authors.affiliation: Department of Internal Medicine, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Karapinar
authors.affiliation: Department of Pathology, Veterinary Faculty, Firat University, Elazig, Turkey.
authors.forename: Yesari
authors.initials: Y
authors.lastname: Eroksuz
authors.affiliation: Department of Animal Nutrition and Nutritional Disorders, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Armagan
authors.initials: A
authors.lastname: Hayirli
authors.affiliation: Department of Pathology, Veterinary Faculty, Kafkas University, Kars, Turkey.
authors.forename: Enver
authors.initials: E
authors.lastname: Beytut
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kaynar
authors.affiliation: Department of Internal Medicine, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.
authors.forename: Ersoy
authors.initials: E
authors.lastname: Baydar
authors.affiliation: Department of Virology, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sozdutmaz
authors.affiliation: Department of Virology, Faculty of Veterinary Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Isidan
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D005260:Female; D015511:Goat Diseases / Q000175:diagnosis* / Q000473:pathology; D006041:Goats; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I
keywords: Biomarker; cTnI; goat; myocardial damage