title: Clinical outcomes in octogenarians treated with docetaxel as first-line chemotherapy for castration-resistant prostate cancer.
abstract: OBJECTIVE
  To assess clinical outcomes in octogenarians treated with docetaxel (DOC) for metastatic castration-resistant prostate cancer.
  
  
  METHODS
  The multicenter retrospective study was based on a review of the pre- and post-DOC clinical history, DOC treatment and outcomes.
  
  
  RESULTS
  We reviewed the records of 123 patients (median age: 82 years) who received DOC every 3 weeks or weekly, without significant grade 3-4 toxicities. Median progression-free survival was 7 months; median overall survival from the start of DOC was 20 months, but post-progression treatments significantly prolonged overall survival.
  
  
  CONCLUSIONS
  The findings of this study suggest that toxicity is acceptable, survival is independent of patient's age and survival can be significantly prolonged by the use of new agents.
authors.affiliation: Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy.
authors.forename: Antonello
authors.initials: A
authors.lastname: Veccia
authors.affiliation: Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy.
authors.forename: Orazio
authors.initials: O
authors.lastname: Caffo
authors.affiliation: Medical Oncology Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via Piero Maroncelli 40, 47014 Meldola, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: De Giorgi
authors.affiliation: Oncologia Urologica, Azienda Ospedaliera Universitaria "Federico II", Via S. Pansini 5, 80131 Napoli, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Lorenzo
authors.affiliation: Medical Oncology Department, Institute for Cancer Research & Treatment, Strada Provinciale 142, Km 3.95, 10060 Candiolo, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Ortega
authors.affiliation: Medical Oncology Department, Cardarelli Hospital, Via A. Cardarelli 9, 80131 Napoli, Italy.
authors.forename: Florinda
authors.initials: F
authors.lastname: Scognamiglio
authors.affiliation: Medical Oncology Department, Referral Cancer Center of Basilicata - IRCCS, Via Padre Pio, 1, 85028 Rionero in Vulture, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Aieta
authors.affiliation: Division of Medical Oncology, Department of Uro-Gynaecological Oncology, Istituto Nazionale Tumori "Fondazione G. Pascale" - IRCCS, Via Mariano Semmola, 80131 Naples, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Facchini
authors.affiliation: Medical Oncology Department, General Hospital, Via Fabi, 03100 Frosinone, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Mansueto
authors.affiliation: Medical Oncology Department, Santa Croce Hospital, Viale Vittorio Veneto 2, 61032 Fano, Italy.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Mattioli
authors.affiliation: Oncologia medica genitourinaria - Fondazione Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Procopio
authors.affiliation: Medical Oncology Unit 1, Istituto Oncologico Veneto IOV - IRCCS, Via Gattamelata 64, 35128 Padua, Italy.
authors.forename: Vittorina
authors.initials: V
authors.lastname: Zagonel
authors.affiliation: Medical Oncology Department, San Vincenzo Hospital, Via Sirina, 98039 Taormina, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: D'Angelo
authors.affiliation: Medical Oncology Department, General Hospital, Via Rossini, 5, 39012 Merano, Italy.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Spizzo
authors.affiliation: Radiation Oncology Department, National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bortolus
authors.affiliation: Medical Oncology Department, Istituti Ospitalieri, Viale Concordia 1, 26100 Cremona, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Donini
authors.affiliation: Medical Oncology Department, Santa Maria degli Angeli Hospital, Via Montereale 24, 33170 Pordenone, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lo Re
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale A. Scuro 10, 37134 Verona, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Massari
authors.affiliation: Medical Oncology Department, San Giacomo Apostolo Hospital, Via dei Carpani 16/Z, 31033 Castelfranco Veneto, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vicario
authors.affiliation: Department of Medical Oncology & Haematology, Humanitas Clinical & Research Center, Via Manzoni, 56, 20089 Rozzano, Italy.
authors.forename: Paolo A
authors.initials: PA
authors.lastname: Zucali
authors.affiliation: Department of Radiological, Oncological & Anatomopathological Sciences, La Sapienza, University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Alesini
authors.affiliation: Medical Oncology Department, Mater Salutis Hospital, Via Gianella, 1, 37045 Legnago, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bonetti
authors.affiliation: Medical Oncology Department, Ramazzini Hospital, Via Guido Molinari, 2, 41012 Carpi, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Mucciarini
authors.affiliation: Medical Oncology Department, Sacro Cuore Don Calabria Hospital, Via don A. Sempreboni, 5, 37024 Negrar, Italy.
authors.forename: Maurizio
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authors.lastname: Nicodemo
authors.affiliation: Medical Oncology Department, Spedali Civili Hospital, P.le Spedali Civili, 1, 25123 Brescia, Italy.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Berruti
authors.affiliation: Medical Oncology Department, National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Fratino
authors.affiliation: Urology Department, General Hospital, Via Böhler 5, 39100 Bolzano, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Lodde
authors.affiliation: Medical Oncology Department, Papa Giovanni XXIII Hospital, Piazza OMS 1, 24127 Bergamo, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Messina
authors.affiliation: Medical Oncology Department, General Hospital, via Garziere n. 42, 36014 Santorso, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Perin
authors.affiliation: Medical Oncology Department, University Campus Bio-Medico, Via Álvaro del Portillo, 00128 Rome, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Santini
authors.affiliation: Medical Oncology Department, General Hospital, P.le A. Stefani 1, 37126 Verona, Italy.
authors.forename: Teodoro
authors.initials: T
authors.lastname: Sava
authors.affiliation: Medical Oncology Department, University of Torino, San Luigi Hospital, Regione Gonzole, 10, 10043 Orbassano, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Tucci
authors.affiliation: Medical Oncology Unit 1, Istituto Oncologico Veneto IOV - IRCCS, Via Gattamelata 64, 35128 Padua, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Basso
authors.affiliation: Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Maines
authors.affiliation: Medical Oncology Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via Piero Maroncelli 40, 47014 Meldola, Italy.
authors.forename: Luca S
authors.initials: LS
authors.lastname: Burgio
authors.affiliation: Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Galligioni
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000077143:Docetaxel; D006801:Humans; D008297:Male; D016016:Proportional Hazards Models; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D019233:Retreatment; D012189:Retrospective Studies; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel
keywords: castration-resistant prostate cancer; docetaxel; elderly; geriatric assessment