title: Anti-GBM Disease in Pregnancy: Acute Renal Failure Resolved After Plasma Exchange, Hemodialysis, and Steroids.
abstract: Antiglomerular basement membrane (GBM) disease presenting during pregnancy is uncommon. We present a case of a pregnant female who presented with acute renal failure requiring dialysis due to anti-GBM disease. She responded well to plasma exchange, high-dose steroids, and hemodialysis. Cyclophosphamide was discussed but not given at the patient's request due to concerns for the well-being of the fetus. Unfortunately, she suffered a spontaneous abortion in her eighth week of pregnancy. Subsequently, she had progressive improvement in her renal function and became hemodialysis independent at 2 weeks after diagnosis. Her renal function returned to baseline 3 months after diagnosis. We present this case in detail and review the literature regarding anti-GBM disease in pregnancy.
authors.affiliation: University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Mohammed Muqeet
authors.initials: MM
authors.lastname: Adnan
authors.affiliation: University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Jordan
authors.initials: J
authors.lastname: Morton
authors.affiliation: University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Syed
authors.initials: S
authors.lastname: Hashmi
authors.affiliation: University of Illinois at Chicago, IL, USA.
authors.forename: Sufyan
authors.initials: S
authors.lastname: Abdul Mujeeb
authors.affiliation: University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: William
authors.initials: W
authors.lastname: Kern
authors.affiliation: University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Cowley
keywords: acute kidney injury; antiglomerular basement membrane disease; glomerulonephritis; pregnancy; therapeutics