title: The role of innate lymphoid cells in healthy and inflamed skin.
abstract: The skin constitutes the interface between the organism and the environment, and it protects the body from harmful substances in the environment via physical, chemical and immunological barriers. The immunological barrier of the skin comprises both cells from the innate and the adaptive immune system. During the last years, it has become clear that innate lymphoid cells play a role in homeostasis and inflammation of the skin in humans and mice. In this review, we will discuss the role of innate lymphoid cells in healthy and inflamed skin with special focus on their role in atopic dermatitis.
authors.affiliation: Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: cmenne@sund.ku.dk.
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Bonefeld
authors.affiliation: Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
authors.forename: Carsten
authors.initials: C
authors.lastname: Geisler
mesh_terms: D000818:Animals; D003872:Dermatitis / Q000209:etiology* / Q000378:metabolism*; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D003876:Dermatitis, Atopic / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D004198:Disease Susceptibility; D000091344:Filaggrin Proteins; D006801:Humans; D007113:Immunity, Innate; D007381:Intermediate Filament Proteins / Q000235:genetics / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D011565:Psoriasis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D012867:Skin / Q000166:cytology / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014945:Wound Healing / Q000235:genetics / Q000276:immunology
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins
keywords: Allergic contact dermatitis; Atopic dermatitis; Filaggrin; ILC; Psoriasis; Skin