title: Genome-wide Analysis of the Role of Copy Number Variation in Schizophrenia Risk in Chinese.
abstract: Compelling evidence suggested the role of copy number variations (CNVs) in schizophrenia susceptibility. Most of the evidence was from studies in populations with European ancestry. We tried to validate the associated CNV loci in a Han Chinese population and identify novel loci conferring risk of schizophrenia.
  
  
  
  We performed a genome-wide CNV analysis on 6588 patients with schizophrenia and 11,904 control subjects of Han Chinese ancestry.
  
  
  
  Our data confirmed increased genome-wide CNV (>500 kb and <1%) burden in schizophrenia, and the increasing trend was more significant when only >1 Mb CNVs were considered. We also replicated several associated loci that were previously identified in European populations, including duplications at 16p11.2, 15q11.2-13.1, 7q11.23, and VIPR2 and deletions at 22q11.2, 1q21.1-q21.2, and NRXN1. In addition, we discovered three additional new potential loci (odds ratio >6, p < .05): duplications at 1p36.32, 10p12.1, and 13q13.3, involving many neurodevelopmental and synaptic related genes.
  
  
  
  Our findings provide further support for the role of CNVs in the etiology of schizophrenia.
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai; Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science; Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai; Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University;Shanghai.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Chen
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, the First Teaching Hospital of Xinjiang Medical University, Urumqi.
authors.forename: Qizhong
authors.initials: Q
authors.lastname: Yi
authors.affiliation: Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University;Shanghai; Changning Mental Health Center, Shanghai.
authors.forename: Weidong
authors.initials: W
authors.lastname: Ji
authors.affiliation: Wuhu Fourth People's Hospital, Wuhu.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Shen
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Song
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Wuhu Fourth People's Hospital, Wuhu.
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Qingzhong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai.
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.affiliation: Longquan Mountain Hospital of Guangxi Province, Liuzhou.
authors.forename: Benxiu
authors.initials: B
authors.lastname: Liu
authors.affiliation: Longquan Mountain Hospital of Guangxi Province, Liuzhou.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Sun
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Baojie
authors.initials: B
authors.lastname: Li
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai; Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University;Shanghai; Institutes of Biomedical Sciences, Fudan University, Shanghai.
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Guang
authors.initials: G
authors.lastname: He
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Li
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Zujia
authors.initials: Z
authors.lastname: Wen
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Jue
authors.initials: J
authors.lastname: Ji
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai.
authors.forename: Xingwang
authors.initials: X
authors.lastname: Li
authors.affiliation: Bio-X Institutes, Shanghai Jiao Tong University, Shanghai; Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science; Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai; Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University;Shanghai; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai; Department of Psychiatry, the First Teaching Hospital of Xinjiang Medical University, Urumqi; Changning Mental Health Center, Shanghai; The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China. Electronic address: shiyongyong@gmail.com.
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics; D002135:Calcium-Binding Proteins; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics; D025063:Chromosome Disorders / Q000235:genetics; D056915:DNA Copy Number Variations / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics; D019006:Neural Cell Adhesion Molecules; D051239:Receptors, Vasoactive Intestinal Peptide, Type II / Q000235:genetics; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
chemical_list: D002135:Calcium-Binding Proteins; D015816:Cell Adhesion Molecules, Neuronal; C539628:NRXN1 protein, human; D009419:Nerve Tissue Proteins; D019006:Neural Cell Adhesion Molecules; D051239:Receptors, Vasoactive Intestinal Peptide, Type II; C495509:VIPR2 protein, human
keywords: 10p12.1; 13q13.3; 1p36.32; Copy number variation; Han Chinese; Schizophrenia