title: Apolipoproteins, lipids and risk of cancer.
abstract: The epidemiological evidence for an obesity-cancer association is solid, whereas the association between obesity-associated lipoprotein levels and cancer is less evident. We investigated circulating levels of Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) and association to risk of overall cancer and common cancer forms. The Malmö Diet and Cancer Study, a population-based prospective cohort study, enrolled 17,035 women and 11,063 men (1991-1996). Incident cancer cases were ascertained by record linkage with the Swedish Cancer Registry until end of follow-up, January 1, 2012. Baseline serum levels of ApoA1 and ApoB were analyzed for the entire cohort and HDL-C and LDL-C levels in 5,281 participants. Hazard ratios, with 95% confidence interval, were calculated using Cox's proportional hazards analysis. In the entire cohort, none of the exposures were related to overall cancer risk (HRadj ApoA1 = 0.98, 95%CI: 0.95,1.01; HRadj ApoB = 1.01, 95%CI: 0.98-1.04). Among men, ApoB was positively associated with cancer risk (HRadj ApoB = 1.06, 95%CI: 1.01,1.10). Female breast cancer risk was inversely associated with ApoB (HRadj = 0.92, 95%CI: 0.86,0.99). Among both genders, ApoA1 was inversely associated with lung cancer risk (HRadj = 0.88, 95%CI: 0.80,0.97), whereas high ApoB increased lung cancer risk (HRadj = 1.08, 95%CI: 0.99,1.18). Colorectal cancer risk was increased with high ApoB (HRadj = 1.08, 95%CI: 1.01,1.16) among both genders. Apolipoprotein levels were not associated with prostate cancer incidence. Circulating levels of apolipoproteins are associated with overall cancer risk in men and across both genders with breast, lung and colorectal cancer risk. Validation of these findings may facilitate future primary prevention strategies for cancer.
authors.affiliation: Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Sweden.|Department of Oncology, Skåne University Hospital, Lund, Sweden.
authors.forename: Signe
authors.initials: S
authors.lastname: Borgquist
authors.affiliation: Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Sweden.
authors.forename: Talha
authors.initials: T
authors.lastname: Butt
authors.affiliation: Division of Cardiology, Malmö, Lund University, Sweden.|Department of Clinical Sciences, Malmö, Lund University, Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Almgren
authors.affiliation: Quest Diagnostics, Alameda, California.
authors.forename: Dov
authors.initials: D
authors.lastname: Shiffman
authors.affiliation: Department of Clinical Sciences, Malmö, Lund University, Sweden.|Division of Diabetes and Cardiovascular Diseases, Genetic Epidemiology, Malmö, Lund University, Sweden.
authors.forename: Tanja
authors.initials: T
authors.lastname: Stocks
authors.affiliation: Department of Clinical Sciences, Malmö, Lund University, Sweden.|Division of Diabetes and Cardiovascular Diseases, Genetic Epidemiology, Malmö, Lund University, Sweden.
authors.forename: Marju
authors.initials: M
authors.lastname: Orho-Melander
authors.affiliation: Department of Clinical Sciences, Malmö, Lund University, Sweden.|Division of Surgery, Malmö, Lund University, Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.affiliation: Division of Cardiology, Malmö, Lund University, Sweden.|Department of Clinical Sciences, Malmö, Lund University, Sweden.
authors.forename: Olle
authors.initials: O
authors.lastname: Melander
mesh_terms: D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids
keywords: apolipoproteins; breast cancer; cancer incidence; colorectal cancer; lung cancer; obesity; prostate cancer