title: Changes in theta activities in the left posterior temporal region, left occipital region and right frontal region related to mild cognitive impairment in Parkinson's disease patients.
abstract: The aim of this study was to investigate changes in brain activity associated with mild cognitive impairment (MCI) in a large sample of nondemented Parkinson's disease (PD) patients and its relationship with specific neuropsychological deficits. Electroencephalography (EEG) and neuropsychological assessment were performed in a sample of 135 nondemented PD patients and 44 healthy controls. All patients underwent a neuropsychological battery to assess global cognitive function. Patients were classified according to their cognitive status as PD patients with MCI (n = 61) and without MCI (n = 74). EEG data were used to analyze the relative band power parameters for the following frequency bands: delta (0.5-4 Hz), theta (4-8 Hz), alpha (8-13 Hz) and beta (13-30 Hz). In addition, relative band power parameters were compared between groups and examined for correlations with neuropsychological performance. The relative theta band powers in three regions (O1, T5 and F4) exhibited statistically significant increases in PD patients with MCI. Beta band powers also exhibited obvious decreases in five regions (T5, T6, P3, P4 and C3) in the PD-MCI group compared with the normal control group. Furthermore, correlation analyses revealed that attention, visuospatial and executive functions were associated with theta power in local regions, mainly in the frontal region (F4). The present study demonstrated that changes in brain activities limited to distinct cognitive domains, especially the theta power in the frontal region, could serve as an electrophysiological marker of cognitive impairment in nondemented PD patients.
authors.affiliation: a Southern Medical University , Guangzhou , Guangdong , PR China.|b Department of Neurology, Guangdong Neuroscience Institute , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , Guangdong , PR China.
authors.forename: Xuetao
authors.initials: X
authors.lastname: He
authors.affiliation: b Department of Neurology, Guangdong Neuroscience Institute , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , Guangdong , PR China.
authors.forename: Yuhu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: b Department of Neurology, Guangdong Neuroscience Institute , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , Guangdong , PR China.
authors.forename: Jieling
authors.initials: J
authors.lastname: Chen
authors.affiliation: b Department of Neurology, Guangdong Neuroscience Institute , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , Guangdong , PR China.
authors.forename: Chunge
authors.initials: C
authors.lastname: Xie
authors.affiliation: b Department of Neurology, Guangdong Neuroscience Institute , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , Guangdong , PR China.
authors.forename: Rong
authors.initials: R
authors.lastname: Gan
authors.affiliation: b Department of Neurology, Guangdong Neuroscience Institute , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , Guangdong , PR China.
authors.forename: Limin
authors.initials: L
authors.lastname: Wang
authors.affiliation: b Department of Neurology, Guangdong Neuroscience Institute , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , Guangdong , PR China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D060825:Cognitive Dysfunction / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000503:physiopathology*; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D013702:Temporal Lobe / Q000503:physiopathology*; D013826:Theta Rhythm / Q000502:physiology*
keywords: Parkinson's disease; electroencephalography; mild cognitive impairment