title: [A case of vascular parkinsonism associated with hyperhomocysteinemia and methylenetetrahydrofolate reductase gene variant (C677T)].
abstract: A 56-year-old man, who presented with 6 years history of difficulty in walking, was diagnosed as having vascular parkinsonism on the basis of the clinical findings of parkinsonism, pyramidal sign and the brain MRI findings of multiple lacunar infarction. Although he did not have hypertension, he had hyperhomocysteinemia and homozygous methylenetetrahydrofolate reductase (MTHFR) gene variant (C677T) as risk factors for ischemic stroke. Recent studies have shown that hyperhomocysteinemia and MTHFR gene variant are associated with small-vessel disease, suggesting that these risk factors may underlie vascular parkinsonism, particularly in patients lacking hypertension and in those with a relatively younger age at onset of this disease.
authors.affiliation: Departrment of Neurology, Akita Red Cross Hospital.
authors.forename: Kenju
authors.initials: K
authors.lastname: Hara
authors.forename: Keigo
authors.initials: K
authors.lastname: Onda
authors.forename: Haruka
authors.initials: H
authors.lastname: Ouchi
authors.forename: Ken
authors.initials: K
authors.lastname: Shibano
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ishiguro
mesh_terms: D017668:Age of Onset; D014644:Genetic Variation; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D006973:Hypertension; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors; D059409:Stroke, Lacunar / Q000175:diagnosis / Q000209:etiology
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)