title: The role of IL-17 in vitiligo: A review.
abstract: IL-17 is involved in the pathogenesis of several autoimmune diseases; however its role in vitiligo has not been well defined. Emerging human and mouse studies have demonstrated that systemic, tissue, and cellular levels of IL-17 are elevated in vitiligo. Many studies have also shown significant positive correlations between these levels and disease activity, extent, and severity. Treatments that improve vitiligo, such as ultraviolet B phototherapy, also modulate IL-17 levels. This review synthesizes our current understanding of how IL-17 may influence the pathogenesis of autoimmune vitiligo at the molecular level. This has implications for defining new vitiligo biomarkers and treatments.
authors.affiliation: University of California - Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: Rasnik.s@gmail.com.
authors.forename: Rasnik K
authors.initials: RK
authors.lastname: Singh
authors.affiliation: Department of Dermatology, University of California-San Francisco, San Francisco, CA 94115, USA.
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Lee
authors.affiliation: Mucosal Immunology Section, National Institute of Allergy & Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Vujkovic-Cvijin
authors.affiliation: Department of Dermatology, University of California-San Francisco, San Francisco, CA 94115, USA.
authors.forename: Derya
authors.initials: D
authors.lastname: Ucmak
authors.affiliation: University of Vermont College of Medicine, Burlington, VT 05405, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Farahnik
authors.affiliation: University of California - Irvine, School of Medicine, Irvine, CA 92697, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Abrouk
authors.affiliation: University of California - San Francisco, Department of Dermatology, Psoriasis and Skin Treatment Center, San Francisco, CA 94118, USA.
authors.forename: Mio
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA.
authors.forename: Tian Hao
authors.initials: TH
authors.lastname: Zhu
authors.affiliation: Department of Dermatology, University of California-San Francisco, San Francisco, CA 94115, USA.
authors.forename: Tina
authors.initials: T
authors.lastname: Bhutani
authors.affiliation: Department of Dermatology, University of California-San Francisco, San Francisco, CA 94115, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Wei
authors.affiliation: Department of Dermatology, University of California-San Francisco, San Francisco, CA 94115, USA.
authors.forename: Wilson
authors.initials: W
authors.lastname: Liao
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D008544:Melanocytes / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology; D014467:Ultraviolet Therapy; D014820:Vitiligo / Q000235:genetics / Q000276:immunology*
chemical_list: D020381:Interleukin-17
keywords: IL-17; Interleukin-17; Vitiligo