title: Non-invasive measurement of abnormal ventilatory mechanics in amyotrophic lateral sclerosis.
abstract: In this study we investigated non-invasive, effort-independent measurement of ventilatory mechanics in patients with amyotrophic lateral sclerosis (ALS).
  
  
  
  Ventilatory mechanics were measured by optoelectronic plethysmography (OEP) in ALS patients and matched controls. Analysis determined whether OEP measurements correlated with standard clinical measures.
  
  
  
  ALS patients (N = 18) had lower forced vital capacity percent predicted (55.2 ± 22.0 L) compared with controls (N = 15; 104.7 ± 16.2 L) and higher ventilatory inefficiency (49.2 ± 9.0 vs. 40.0 ± 3.5, respectively; P < 0.001 for both measures). Lower tidal volumes within the diaphragm area correlated with the dyspnea subscore calculated from the ALS Functional Rating Scale-revised (P = 0.031), and paradoxical movement of the ribcage compared with the abdominal compartment was seen in the most severe cases.
  
  
  
  Evaluation of ventilatory mechanics in mild to severe ALS reveals dysfunction that is not readily detected by standard testing and ALS functional severity assessment measures. Muscle Nerve 54: 270-276, 2016.
authors.affiliation: Division of Pulmonary, Allergy, Critical Care, Department of Medicine, Columbia University College of Physicians and Surgeons, 622 West 168th Street, New York, New York, 10032, USA.
authors.forename: Aimee M
authors.initials: AM
authors.lastname: Layton
authors.affiliation: Department of Pulmonary and Critical Care Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, Hempstead, New York, USA.
authors.forename: Sienna L
authors.initials: SL
authors.lastname: Moran
authors.affiliation: Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA.
authors.forename: Arindham
authors.initials: A
authors.lastname: Roychoudhury
authors.affiliation: Department of Neurology, The Eleanor and Lou Gehrig MDA/ALS Research Center, Columbia University College of Physicians and Surgeons, New York, New York, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hupf
authors.affiliation: Division of Pulmonary, Allergy, Critical Care, Department of Medicine, Columbia University College of Physicians and Surgeons, 622 West 168th Street, New York, New York, 10032, USA.
authors.forename: Byron M
authors.initials: BM
authors.lastname: Thomashow
authors.affiliation: Department of Neurology, The Eleanor and Lou Gehrig MDA/ALS Research Center, Columbia University College of Physicians and Surgeons, New York, New York, USA.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitsumoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061088:Photoacoustic Techniques; D012131:Respiratory Insufficiency / Q000175:diagnosis* / Q000209:etiology*; D012122:Ventilators, Mechanical; D014797:Vital Capacity / Q000502:physiology; D055815:Young Adult
keywords: ALS; diaphragm; forced vital capacity; plethysmography; ventilatory mechanics