title: ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis.
abstract: OBJECTIVE
  To find the association of ATIC 347C>G gene polymorphism with methotrexate (MTX) treatment response and MTX-induced adverse events in south Indian Tamil patients with rheumatoid arthritis.
  
  
  METHODS
  A total of 319 rheumatoid arthritis and 310 healthy controls were recruited for the study and ATIC 347C>G gene polymorphism was analyzed by PCR-RFLP method.
  
  
  RESULTS
  The genotype and allele frequencies of ATIC 347 C>G SNP did not differ between good and nonresponders and hence this SNP was not found to be associated with MTX treatment response. However, the ATIC 347 GG genotype (p = 0.02; odds ratio [OR]: 4.46; 95% CI: 1.28-15.52) and mutant G allele was associated with MTX-induced gastrointestinal adverse events (p = 0.01; OR: 2.60; 95% CI: 1.27-5.35).
  
  
  CONCLUSIONS
  ATIC 347C>G gene polymorphism may be associated with the development of MTX induced gastrointestinal adverse events.
authors.affiliation: Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India.
authors.forename: Niveditha
authors.initials: N
authors.lastname: Muralidharan
authors.affiliation: Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Mariaselvam
authors.affiliation: Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India.
authors.forename: Vikramraj K
authors.initials: VK
authors.lastname: Jain
authors.affiliation: Genetic Services Unit, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India.
authors.forename: Reena
authors.initials: R
authors.lastname: Gulati
authors.affiliation: Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India.
authors.forename: Vir S
authors.initials: VS
authors.lastname: Negi
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D005006:Ethnicity; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D019877:Hydroxymethyl and Formyl Transferases / Q000235:genetics*; D007194:India; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D009097:Multienzyme Complexes / Q000235:genetics*; D009154:Mutation; D009709:Nucleotide Deaminases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D018501:Antirheumatic Agents; D009097:Multienzyme Complexes; C113120:inosine monophosphate synthase; D019877:Hydroxymethyl and Formyl Transferases; D009709:Nucleotide Deaminases; D008727:Methotrexate
keywords: ATIC 347C>G; adenosine; adverse events; methotrexate; rheumatoid arthritis; south Indian; treatment response