title: Place of Interferon-γ Assay for Diagnosis of Congenital Toxoplasmosis.
abstract: The diagnosis of congenital toxoplasmosis relies mainly on serology. When results are doubtful, pediatricians have difficulties with respect to treatment. We report interferon-γ responses after the stimulation of blood by Toxoplasma gondii antigen in 17 infected infants and 80 infants free of infection. Sensitivity and specificity were 93.75% (95% confidence interval: 67%-99%) and 98.75% (95% confidence interval: 92%-99%), respectively.
authors.affiliation: From the *Université Claude Bernard Lyon 1, Service de Parasitologie, Faculté de Médecine Lyon Sud, Lyon, France; †Hospices Civils de Lyon, Service de Parasitologie, Hôpital de la Croix Rousse, Lyon, France; ‡Centre de Recherche en Neurosciences de Lyon, Université Claude-Bernard Lyon, Lyon, France; and §Laboratoire de Parasitologie et Mycologie, Centre Hospitalo-Universitaire de la Timone, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Chapey
authors.forename: Martine
authors.initials: M
authors.lastname: Wallon
authors.forename: Coralie
authors.initials: C
authors.lastname: L'Ollivier
authors.forename: Renaud
authors.initials: R
authors.lastname: Piarroux
authors.forename: François
authors.initials: F
authors.lastname: Peyron
mesh_terms: D000293:Adolescent; D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood* / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D059425:Interferon-gamma Release Tests; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan