title: Cardiac dysfunction during exacerbations of chronic obstructive pulmonary disease.
abstract: Chronic obstructive pulmonary disease (COPD) and cardiovascular disease often coexist, and acute cardiac events frequently occur during COPD exacerbations. Even when cardiac complications are not clinically apparent, biochemical evidence of cardiac dysfunction is often noted during exacerbations and portends poor prognosis. Diagnosis of cardiac disease in COPD can be difficult and necessitates a high degree of clinical suspicion. However, the additional strain of an exacerbation could be a pivotal moment, during which previously unsuspected cardiac dysfunction is exposed. In this Review, we present evidence about cardiac involvement in exacerbations of COPD, and discuss diagnostic challenges and treatment opportunities.
authors.affiliation: Monash Lung & Sleep, Monash Medical Centre, Monash University, Melbourne, VIC, Australia. Electronic address: martin.macdonald@monashhealth.org.
authors.forename: Martin I
authors.initials: MI
authors.lastname: MacDonald
authors.affiliation: Department of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand; Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.
authors.forename: Eskandarain
authors.initials: E
authors.lastname: Shafuddin
authors.affiliation: Monash Lung & Sleep, Monash Medical Centre, Monash University, Melbourne, VIC, Australia.
authors.forename: Paul T
authors.initials: PT
authors.lastname: King
authors.affiliation: Department of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand.
authors.forename: Catherina L
authors.initials: CL
authors.lastname: Chang
authors.affiliation: Monash Lung & Sleep, Monash Medical Centre, Monash University, Melbourne, VIC, Australia.
authors.forename: Philip G
authors.initials: PG
authors.lastname: Bardin
authors.affiliation: Department of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand; Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hancox
mesh_terms: D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D018450:Disease Progression; D006331:Heart Diseases / Q000453:epidemiology*; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000628:therapy