title: Oxidative Stress-Mediated Skeletal Muscle Degeneration: Molecules, Mechanisms, and Therapies.
abstract: Oxidative stress is a loss of balance between the production of reactive oxygen species during cellular metabolism and the mechanisms that clear these species to maintain cellular redox homeostasis. Increased oxidative stress has been associated with muscular dystrophy, and many studies have proposed mechanisms that bridge these two pathological conditions at the molecular level. In this review, the evidence indicating a causal role of oxidative stress in the pathogenesis of various muscular dystrophies is revisited. In particular, the mediation of cellular redox status in dystrophic muscle by NF-κB pathway, autophagy, telomere shortening, and epigenetic regulation are discussed. Lastly, the current stance of targeting these pathways using antioxidant therapies in preclinical and clinical trials is examined.
authors.affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117597.
authors.forename: Min Hee
authors.initials: MH
authors.lastname: Choi
authors.affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117597.
authors.forename: Jin Rong
authors.initials: JR
authors.lastname: Ow
authors.affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
authors.forename: Nai-Di
authors.initials: ND
authors.lastname: Yang
authors.affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117597.
authors.forename: Reshma
authors.identifier: 0000-0002-2151-2094
authors.initials: R
authors.lastname: Taneja
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000473:pathology*; D009133:Muscular Atrophy / Q000628:therapy*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species