title: Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.
abstract: A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.
authors.affiliation: UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA. john.kurhanewicz@ucsf.edu and Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
authors.forename: D E
authors.initials: DE
authors.lastname: Korenchan
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
authors.forename: R R
authors.initials: RR
authors.lastname: Flavell
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
authors.forename: C
authors.initials: C
authors.lastname: Baligand
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
authors.forename: R
authors.initials: R
authors.lastname: Sriram
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
authors.forename: K
authors.initials: K
authors.lastname: Neumann
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
authors.forename: S
authors.initials: S
authors.lastname: Sukumar
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
authors.forename: H
authors.initials: H
authors.lastname: VanBrocklin
authors.affiliation: UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA. john.kurhanewicz@ucsf.edu and Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
authors.forename: D B
authors.initials: DB
authors.lastname: Vigneron
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
authors.forename: D M
authors.initials: DM
authors.lastname: Wilson
authors.affiliation: UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA. john.kurhanewicz@ucsf.edu and Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
authors.forename: J
authors.initials: J
authors.lastname: Kurhanewicz
mesh_terms: D001672:Biocompatible Materials; D002247:Carbon Isotopes / Q000737:chemistry*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D006863:Hydrogen-Ion Concentration
chemical_list: D001672:Biocompatible Materials; D002247:Carbon Isotopes