title: Expression of androgen receptor and cyclooxygenase-2 in the vesicular glands of castrated and intact goat.
abstract: This study was conducted to demonstrate the effect of castration on the structure of vesicular glands of the Egyptian Nubian (Zaraibi) goat. Vesicular glands of castrated (n=4) and intact (n=6) goat were used for histological and immunohistochemical evaluations. In this study, we report the difference in cell specific expression of androgen receptor (AR) and cyclooxygenase-2 (COX-2) in the vesicular glands of castrated and intact goats. In both castrated and intact goats, the present study revealed no immunopositive cells for AR or COX-2 in the fibromuscular stroma meanwhile, AR and COX-2 containing immunoreactive cells were restricted only to the epithelium of the secretory acini of the vesicular gland. Such finding suggests androgen and COX-2 as important regulators for the growth and secretory activity of epithelial cells in the vesicular gland of goats. Overall, the vesicular gland of castrated goats showed significantly (P<0.05) lower AR and COX-2 immuno-expression than intact goats indicating that both AR and COX-2 are androgen dependent.
authors.affiliation: Histology and Cytology Department, Faculty of Veterinary Medicine, Benha University, 13736, Egypt. Electronic address: mahmoud.hussein@fvtm.bu.edu.eg.
authors.forename: Mahmoud Abdelghaffar
authors.initials: MA
authors.lastname: Emam
mesh_terms: D000818:Animals; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D006041:Goats / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D011944:Receptors, Androgen / Q000378:metabolism*; D012669:Seminal Vesicles / Q000166:cytology / Q000201:enzymology*
chemical_list: D011944:Receptors, Androgen; D051546:Cyclooxygenase 2
keywords: Androgen receptor; Castration; Cyclooxygenase-2; Goat; Immunohistochemistry; Vesicular gland