title: Near-Infrared Image Reconstruction of Newborns' Brains: Robustness to Perturbations of the Source/Detector Location.
abstract: The brain of preterm infants is the most vulnerable organ and can be severely injured by cerebral ischemia. We are working on a near-infrared imager to early detect cerebral ischemia. During imaging of the brain, movements of the newborn infants are inevitable and the near-infrared sensor has to be able to function on irregular geometries. Our aim is to determine the robustness of the near-infrared image reconstruction to small variations of the source and detector locations. In analytical and numerical simulations, the error estimations for a homogeneous medium agree well. The worst case estimates of errors in reduced scattering and absorption coefficient for distances of r=40 mm are acceptable for a single source-detector pair. The optical properties of an inhomogeneity representing an ischemia are reconstructed correctly within a homogeneous medium, if the error in placement is random.
authors.affiliation: Biomedical Optics Research Laboratory, University Hospital Zurich, Zurich, Switzerland. linda.ahnen@usz.ch.
authors.forename: L
authors.initials: L
authors.lastname: Ahnen
authors.affiliation: Biomedical Optics Research Laboratory, University Hospital Zurich, Zurich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Wolf
authors.affiliation: Division of Neonatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Hagmann
authors.affiliation: Biomedical Optics Research Laboratory, University Hospital Zurich, Zurich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Sanchez
mesh_terms: D001921:Brain / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
keywords: Near-infrared imaging; Optical properties; Optoacoustic imaging; Reconstruction; Stability