title: [Alcohol--when it's beneficial to your health?].
abstract: Ethyl alcohol is the most commonly used psychoactive agent. It's average consumption in Poland totaled 9.67 liters per capita in 2013. Ethanol's biotransformation rate in an adult ranges from 7 to 10 grams per hour. The basic metabolism takes place in the liver through the oxidation involving NAD+. The alcohol is transformed first into acetaldehyde and then into acetic acid. In higher blood concentrations or in alcoholism, cytochrome's P-450 coenzyme CYP2E1 also plays an important role in this process. Alcohol is responsible for nearly 50% of annual deaths, mostly caused by an accident due to alcohol intoxication while driving. Studies were performed to determine the influence ethanol has on the human body and how it impacts the progression of illnesses such as senile dementia, cardiovascular diseases or osteoporosis. Scientists' attention was drawn to the possibility of ethyl alcohol's usage resulting in a reduction in an overall mortality rate, however the beneficial effects were observed only during a slight and moderate consumption. Higher doses of alcohol were associated with a decline in patient's condition. The purpose of this dissertation is an attempt to answer the question, whether the alcohol can be beneficial to the user's health and if so, in what doses? The importance of this topic comes from the fact that due to the alcohol being widely available, determining the influence it has on human body is vital for public health. Original articles and reviews were used to summarize the results of studies regarding the topic.
authors.affiliation: Medical University of Wrocław, Chair and Department of Endocrynology, Diabetology and Isotopy Treatment.
authors.forename: Zygmumt
authors.initials: Z
authors.lastname: Zdrojewicz
authors.affiliation: Physician Faculty.
authors.forename: Damian
authors.initials: D
authors.lastname: Pypno
authors.affiliation: Physician Faculty.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Bugaj
authors.affiliation: Physician Faculty.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Cabała
mesh_terms: D000437:Alcoholism / Q000453:epidemiology* / Q000401:mortality; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism* / Q000633:toxicity; D062489:Health Impact Assessment; D006801:Humans; D008099:Liver / Q000378:metabolism; D011044:Poland; D014920:Wine
chemical_list: D000431:Ethanol; D019392:Cytochrome P-450 CYP2E1
keywords: atherosclerosis; dementia; ethanol; hypertension; osteoporosis