title: REQUIREMENT OF THE TEC FAMILY TYROSINE KINASE BTK29A FOR COURTSHIP MEMORY IN Drosophila MALES.
abstract: A male Drosophila that is not successful in courtship will reduce his courtship efforts in the next encounter with a female. This courtship suppression persists for more than 1 h in wild-type males. The Btk29A(ficP) mutant males null for the Btk29A type 2 isoform, a fly homolog of the nonreceptor tyrosine kinase Btk, show no courtship suppression, while Btk29A hypomorphic males exhibit a rapid decline in courtship suppression, leading to its complete loss within 30 min. The males of a revertant stock or Btk29A(ficP) males that are also mutant for parkas, a gene encoding the presumptive negative regulator of Btk29A, exhibit normal courtship suppression. Since another behavioral assay has shown that Btk29A(ficP) mutants are sensitization-defective, we hypothesize that the mutant flies are unable to maintain the neural excitation state acquired by experience, resulting in the rapid loss of courtship suppression.
authors.affiliation: Division of Neurogenetics, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sunouchi
authors.affiliation: Division of Neurogenetics, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Koganezawa
authors.affiliation: Division of Neurogenetics, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D003380:Courtship; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D008297:Male; D008568:Memory; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D012726:Sexual Behavior, Animal
chemical_list: D011505:Protein-Tyrosine Kinases; C474449:Btk29A protein, Drosophila
keywords: D. melanogaster; Src; experience-dependence; plasticity; short-term memory