title: [A Case of Neuroendocrine Carcinoma of the Gallbladder].
abstract: A 58-year-old woman presented to our hospital with a huge hepatic mass. A CT scan showed an enhanced mass lesion on the fundus of the gallbladder and an enhanced mass ring on the gallbladder bed. Since FDG-PET showed no evidence of metastasis, we performed cholecystectomy, hepatectomy of S4a/5, and regional lymph node dissection. The immunohistochemical study of the specimen was positive for CK7, CK20, chromogranin A, and synaptophysin. The Ki-67 labeling index was 50%, and the SSTR2 score was 2+. The patient was diagnosed with neuroendocrine carcinoma. Since she was in poor condition and on hemodialysis, we started administration of somatostatin analog at the time of recurrence, and soon her diarrhea improved but the tumor increased in size.
authors.affiliation: Dept. of Surgery, Kansai Rosai Hospital.
authors.forename: Tomo
authors.initials: T
authors.lastname: Ishida
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ohmura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takeda
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Katsura
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohneda
authors.forename: Yurina
authors.initials: Y
authors.lastname: Motoyama
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Sato
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kuwahara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Naito
authors.forename: Kohei
authors.initials: K
authors.lastname: Murakami
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kagawa
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Okishiro
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeno
authors.forename: Chiyomi
authors.initials: C
authors.lastname: Egawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kato
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tamura
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D002763:Cholecystectomy; D005260:Female; D005706:Gallbladder Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D006435:Renal Dialysis; D014057:Tomography, X-Ray Computed