title: [Two Cases of Pathological Complete Response with Neoadjuvant Therapy for Advanced Rectal Cancer].
abstract: We report the cases of 2 patients with advanced rectal cancer who achieved pathological complete response to treatment with preoperative therapy. Case 1 was a 72-year-old man diagnosed with cT3N1M0 advanced rectal cancer. Neoadjuvant chemoradiotherapy with S-1 (120 mg/day) and radiation (50 Gy/25 Fr) was administered. Eight weeks after the last chemoradiation therapy, we performed laparoscopic Hartmann's operation. Case 2 was a 59-year-old man diagnosed with cT4aN0M0 advanced rectal cancer. He was treated with XELOX plus bevacizumab as neoadjuvant chemotherapy. Four weeks after 4 courses of treatment, he underwent laparoscopic Mile's operation. Neoadjuvant therapy was performed without any complications, and a pathological complete response was achieved in both patients. These cases demonstrated that neoadjuvant therapy can be a promising option for locally advanced rectal cancer.
authors.affiliation: Dept. of Gastroenterological Surgery, Osaka General Medical Center.
authors.forename: Chu
authors.initials: C
authors.lastname: Matsuda
authors.forename: Katsuki
authors.initials: K
authors.lastname: Danno
authors.forename: Susumu
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Fujitani
authors.forename: Masaru
authors.initials: M
authors.lastname: Kubota
authors.forename: Masaaki
authors.initials: M
authors.lastname: Motoori
authors.forename: Rie
authors.initials: R
authors.lastname: Nakatsuka
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Okumura
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Nomura
authors.forename: Masashige
authors.initials: M
authors.lastname: Nishimura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kitagawa
authors.forename: Norihiro
authors.initials: N
authors.lastname: Matsuura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Fushimi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Iwase
mesh_terms: D000368:Aged; D059248:Chemoradiotherapy; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000473:pathology* / Q000628:therapy; D012074:Remission Induction