title: The Emerging Therapeutic Role of NGF in Alzheimer's Disease.
abstract: Alzheimer's disease (AD) is the most common type of neurodegenerative dementia that affects the elderly population. Nerve growth factor (NGF) contributes to the survival, regeneration and death of neurons during aging and in neurodegenerative diseases. Recently, research has shown that NGF is related to the pathology, mechanisms and symptoms of AD. Therefore, there is a need to summarize the new advancements in NGF research and its potential therapeutic implications in AD. In this review, we will focus on NGF distribution, production, and function; the interaction of Aβ and NGF; and the effect of different therapy methods on AD. In summary, we hope to describe the experimental and clinical data demonstrating the important roles of NGF for AD treatment.
authors.affiliation: Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Cha Shan, University Town, Wenzhou, 325035, Zhejiang, China. xuzhaojin@gmail.com.
authors.forename: Chao-Jin
authors.initials: CJ
authors.lastname: Xu
authors.affiliation: Department of Clinical Laboratory, Fudan University Affiliated Huadong Hospital, Shanghai, 200040, China.
authors.forename: Jun-Ling
authors.initials: JL
authors.lastname: Wang
authors.affiliation: Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. weilinjin@yahoo.com.
authors.forename: Wei-Lin
authors.initials: WL
authors.lastname: Jin
mesh_terms: D015670:Acupuncture Therapy / Q000639:trends; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000628:therapy*; D000818:Animals; D015316:Genetic Therapy / Q000639:trends; D006801:Humans; D020932:Nerve Growth Factor / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics; D028321:Plant Preparations / Q000627:therapeutic use; D033581:Stem Cell Transplantation / Q000639:trends
chemical_list: C502240:NGF protein, human; D028321:Plant Preparations; D020932:Nerve Growth Factor
keywords: Alzheimer’s disease (AD); Aβ; NGF; Therapeutic implication