title: BIRADS 3 MRI lesions: Was the initial score appropriate and what is the value of the blooming sign as an additional parameter to better characterize these lesions?
abstract: OBJECTIVE
  To investigate whether there were suspicious criteria on the initial MRI in BIRADS 3 lesions. To analyze the value of "blooming sign" as an additional criterion for malignancy.
  
  
  METHODS
  In this retrospective study the lesion morphological and enhancement characteristics were analyzed. The "blooming sign" (BS), defined as the lesion size increase between the early and the late phase after gadolinium was assessed. We determined the optimal cut-off value for the BS to distinguish benign and malignant breast lesions.
  
  
  RESULTS
  100 lesions were classified BIRADS 3 in 75 patients (12%). Four of the five malignant lesions had suspicious BIRADS criteria on the index MRI. 45 lesions were stable and 30 lesions resolved spontaneously during the follow-up MRI. The optimal cut-off value for the BS was 8.54% with 100% sensitivity, 94% specificity, 44% positive and 100% negative predictive values. Using reclassification rule to upgrade benign BIRADS lesions with suspicious BS feature and downgrade suspicious BIRADS lesions with benign BS feature increased MRI specificity (89%), sensitivity (100%) while preserving NPV (100%).
  
  
  CONCLUSIONS
  This study showed the suggestive part of classified BIRADS 3 lesions. The blooming sign seems to be a good additional parameter to increase MRI specificity when associated to BIRADS criteria.
authors.affiliation: Women Medical Imaging Department, Jeanne de Flandre Hospital CHRU Lille, Lille Nord University, Lille, France.
authors.forename: Ralphy
authors.initials: R
authors.lastname: Guillaume
authors.affiliation: Medical Imaging Department, Oscar Lambret Center, Lille Nord University, Lille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Taieb
authors.affiliation: Medical Imaging Department, Oscar Lambret Center, Lille Nord University, Lille, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Ceugnart
authors.affiliation: Biostatistics Department, EA2694, UDSL, Lille Nord University, Lille, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Deken-Delannoy
authors.affiliation: Women Medical Imaging Department, Jeanne de Flandre Hospital CHRU Lille, Lille Nord University, Lille, France. Electronic address: faye.nath@gmail.com.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Faye
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
keywords: BIRADS 3; Blooming sign; Breast MRI; Follow-up; High-risk women