title: Antibiotics and Breastfeeding.
abstract: During the breastfeeding period, bacterial infections can occur in the nursing mother, requiring the use of antibiotics. A lack of accurate information may lead health care professionals and mothers to suspend breastfeeding, which may be unnecessary. This article provides information on the main antibiotics that are appropriate for clinical use and the interference of these antibiotics with the infant to support medical decisions regarding the discontinuation of breastfeeding. We aim to provide information on the pharmacokinetic factors that interfere with the passage of antibiotics into breast milk and the toxicological implications of absorption by the infant. Publications related to the 20 most frequently employed antibiotics and their transfer into breast milk were evaluated. The results demonstrate that most antibiotics in clinical use are considered suitable during breastfeeding; however, the pharmacokinetic profile of each drug must be observed to ensure the resolution of the maternal infection and the safety of the infant.
authors.forename: Fernando
authors.initials: F
authors.lastname: de Sá Del Fiol
authors.forename: Silvio
authors.initials: S
authors.lastname: Barberato-Filho
authors.forename: Cristiane
authors.initials: C
authors.lastname: de Cássia Bergamaschi
authors.forename: Luciane Cruz
authors.initials: LC
authors.lastname: Lopes
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Gauthier
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D001424:Bacterial Infections / Q000188:drug therapy; D001942:Breast Feeding; D005260:Female; D006801:Humans; D007223:Infant; D007774:Lactation; D008895:Milk, Human / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents