title: Structural insights into nonvesicular lipid transport by the oxysterol binding protein homologue family.
abstract: Sterols such as cholesterol in mammals and ergosterol in fungi are essential membrane components and play a key role in membrane function and in cell signaling. The intracellular distribution and processing of sterols and other phospholipids are in part carried out by oxysterol binding protein-related proteins (ORPs) in eukaryotes. Seven ORPs (Osh1-Osh7 proteins) in yeast have distinct functions in maintaining distribution, metabolism and signaling of intracellular lipids but they share at least one essential function. Significant progress has been made in understanding the ligand specificity and mechanism of non-vesicular lipid transport by ORPs. The unique structural features of Osh proteins explain the diversity and specificity of functions in PI(4)P-coupled lipid transport optimized in membrane contact sites. This review discusses the current advances in structural biology regarding this protein family and its potential functions, introducing them as the key players in the novel pathways of phosphoinositide-coupled directional transport of various lipids. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon.
authors.affiliation: College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, South Korea.
authors.forename: Junsen
authors.initials: J
authors.lastname: Tong
authors.affiliation: College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, South Korea.
authors.forename: Mohammad Kawsar
authors.initials: MK
authors.lastname: Manik
authors.affiliation: College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, South Korea.
authors.forename: Huiseon
authors.initials: H
authors.lastname: Yang
authors.affiliation: College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, South Korea. Electronic address: imyoungjun@jnu.ac.kr.
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Im
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000235:genetics; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology*; D008958:Models, Molecular; D005810:Multigene Family; D054730:Protein Interaction Domains and Motifs / Q000502:physiology; D011987:Receptors, Steroid / Q000737:chemistry* / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship; D000098825:Oxysterol Binding Proteins
chemical_list: D011987:Receptors, Steroid; D000098825:Oxysterol Binding Proteins
keywords: Lipid; Lipid transport proteins; Membrane contact sites; Oxysterol binding protein; Phosphatidylserine; Phosphoinositide; Sterol; Structure