title: Portable Upconversion Nanoparticles-Based Paper Device for Field Testing of Drug Abuse.
abstract: We report the first portable upconversion nanoparticles (UCNPs)-based paper device for road-side field testing of cocaine. Upon the recognition of cocaine by two pieces of rationally designed aptamer fragments, the luminescence of UCNPs immobilized on the paper is quenched by Au nanoparticles (AuNPs), which indicates the cocaine concentration. This device can give quantitative results in a short time with high sensitivity using only a smartphone as the apparatus. Moreover, this device is applicable in human saliva samples, and it also can be used to monitor the cocaine content change in blood samples. The results of this work demonstrate the prospect of developing UCNPs-based paper devices for field testing of drug abuse.
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, China.|State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, Hunan 410082, P. R. China.
authors.forename: Mengyuan
authors.initials: M
authors.lastname: He
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, China.|State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, Hunan 410082, P. R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, China.|State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, Hunan 410082, P. R. China.
authors.forename: Yiying
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, China.|State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, Hunan 410082, P. R. China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Liu
mesh_terms: D003042:Cocaine / Q000097:blood*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D049449:Luminescence; D053768:Metal Nanoparticles / Q000737:chemistry*; D010209:Paper; D019966:Substance-Related Disorders / Q000097:blood / Q000175:diagnosis*
chemical_list: D006046:Gold; D003042:Cocaine