title: The Effectiveness of Influenza Vaccination in Different Groups.
abstract: Annual administration of the seasonal influenza vaccine, especially to persons known to be at elevated risk for developing serious complications, is the focus of current efforts to reduce the impact of influenza. The main factors influencing estimated inactivated influenza vaccine efficacy and effectiveness, the results obtained in different population groups, current vaccination strategies and the possible advantages of new vaccines are discussed. The available evidence suggests that influenza vaccines are less effective in the elderly than in young adults, but vaccination is encouraged by public health institutions due to higher mortality and complications. There is no consensus on universal vaccination of children yet economic studies suggest that yearly paediatric vaccination is cost saving. The benefits of herd immunity generated by paediatric vaccination require further study. Newer vaccines should be more and more-broadly protective, stable, easy to manufacture and administer and highly immunogenic across all population groups.
authors.affiliation: a Department de Salut Pública , Universitat de Barcelona , Barcelona , Spain.|b CIBER Epidemiologia y Salut Pública (CIBERESP) , Madrid , Spain.
authors.forename: Angela
authors.initials: A
authors.lastname: Domínguez
authors.affiliation: b CIBER Epidemiologia y Salut Pública (CIBERESP) , Madrid , Spain.|c Agencia de Salut Pública de Catalunya , Generalitat de Catalunya , Barcelona , Spain.
authors.forename: Pere
authors.initials: P
authors.lastname: Godoy
authors.affiliation: a Department de Salut Pública , Universitat de Barcelona , Barcelona , Spain.|b CIBER Epidemiologia y Salut Pública (CIBERESP) , Madrid , Spain.|c Agencia de Salut Pública de Catalunya , Generalitat de Catalunya , Barcelona , Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Torner
mesh_terms: D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D044382:Population Groups; D016896:Treatment Outcome
chemical_list: D007252:Influenza Vaccines
keywords: Influenza vaccines; effectiveness; efficacy; risk groups; study design; vaccination policies