title: Investigation of the differentiation of ex vivo nerve and fat tissues using laser-induced breakdown spectroscopy (LIBS): Prospects for tissue-specific laser surgery.
abstract: In the present study, the elemental compositions of fat and nerve tissue during their plasma mediated laser ablation are studied in the context of tissue differentiation for laser surgery applications by using Laser-Induced Breakdown Spectroscopy (LIBS). Tissue samples of porcine fat and nerve were prepared as ex vivo experimental objects. Plasma mediated laser ablation is performed using an Nd : YAG laser in open air and under normal stray light conditions. The performed measurements suggest that the two tissue types show a high similarity in terms of qualitative elemental composition while at the same time revealing a distinct difference in the concentration of the constituent elements. Different analysis approaches are evaluated and discussed to optimize the tissue-differentiation performance of the LIBS approach. Plasma mediated laser tissue ablation.
authors.affiliation: Clinical Photonics Lab, Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Str. 6, 91052, Erlangen, Germany. Fanuel.Mehari@lpt.uni-erlangen.de.|Institute of Photonics Technologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Konrad-Zuse-Str. 3/5, 91052, Erlangen, Germany. Fanuel.Mehari@lpt.uni-erlangen.de.
authors.forename: Fanuel
authors.initials: F
authors.lastname: Mehari
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glückstraße 11, 91054, Erlangen, Germany.
authors.forename: Maximillian
authors.initials: M
authors.lastname: Rohde
authors.affiliation: Clinical Photonics Lab, Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Str. 6, 91052, Erlangen, Germany.|Institute of Photonics Technologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Konrad-Zuse-Str. 3/5, 91052, Erlangen, Germany.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kanawade
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glückstraße 11, 91054, Erlangen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Knipfer
authors.affiliation: Chair of Biometry and Epidemiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Waldstraße 6, 91054, Erlangen, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Adler
authors.affiliation: Institute of Photonics Technologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Konrad-Zuse-Str. 3/5, 91052, Erlangen, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Klämpfl
authors.affiliation: Clinical Photonics Lab, Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Str. 6, 91052, Erlangen, Germany.|Department of Oral and Maxillofacial Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glückstraße 11, 91054, Erlangen, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Stelzle
authors.affiliation: Clinical Photonics Lab, Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Str. 6, 91052, Erlangen, Germany.|Institute of Photonics Technologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Konrad-Zuse-Str. 3/5, 91052, Erlangen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Schmidt
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D053685:Laser Therapy; D007834:Lasers; D008027:Light; D009474:Neurons / Q000166:cytology*; D013057:Spectrum Analysis; D013552:Swine
keywords: Laser induced-breakdown spectroscopy; elements; fat-nerve; laser surgery; plasma