title: Regulation of global and specific mRNA translation by the mTOR signaling pathway.
abstract: The translation of mRNA into polypeptides is a key step in eukaryotic gene expression. Translation is mostly controlled at the level of initiation, which is partly regulated by the mammalian/mechanistic target of rapamycin (mTOR) signaling pathway. Whereas mTOR controls global protein synthesis through specific effector proteins, its role in the translation of select groups of mRNAs, such as those harboring a terminal oligopyrimidine (TOP) tract at their 5' end, remains more enigmatic. In this article, we describe the current knowledge on the role of mTOR in global mRNA translation, but also focus on the potential molecular mechanisms underlying the regulation of specific translational programs.
authors.affiliation: Institute for Research in Immunology and Cancer (IRIC); Université de Montréal ; Montréal, Québec, Canada.
authors.forename: Neethi
authors.initials: N
authors.lastname: Nandagopal
authors.affiliation: Institute for Research in Immunology and Cancer (IRIC); Université de Montréal; Montréal, Québec, Canada; Department of Pathology and Cell Biology; Faculty of Medicine; Université de Montréal; Montréal, Québec, Canada.
authors.forename: Philippe P
authors.initials: PP
authors.lastname: Roux
keywords: mRNA translation; mTOR; mTORC1; protein synthesis; rapamycin