title: Trace elements are associated with urinary 8-hydroxy-2'-deoxyguanosine level: a case study of college students in Guangzhou, China.
abstract: Many trace heavy elements are carcinogenic and increase the incidence of cancer. However, a comprehensive study of the correlation between multiple trace elements and DNA oxidative damage is still lacking. The aim of this study is to investigate the relationships between the body burden of multiple trace elements and DNA oxidative stress in college students in Guangzhou, China. Seventeen trace elements in urine samples were determined by inductively coupled plasma-mass spectrometry (ICP-MS). Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of DNA oxidative stress, was also measured using liquid chromatography tandem mass spectrometer (LC-MS/MS). The concentrations of six essential elements including manganese (Mn), copper (Cu), nickel (Ni), selenium (Se), strontium (Sr), and molybdenum (Mo), and five non-essential elements including arsenic (As), cadmium (Cd), aluminum (Al), stibium (Sb), and thallium (Tl), were found to be significantly correlated with urinary 8-OHdG levels. Moreover, urinary levels of Ni, Se, Mo, As, Sr, and Tl were strongly significantly correlated with 8-OHdG (P < 0.01) concentration. Environmental exposure and dietary intake of these trace elements may play important roles in DNA oxidative damage in the population of Guangzhou, China.
authors.affiliation: Shenzhen Centers for Disease Control and Prevention, Shenzhen, 518055, China.
authors.forename: Shaoyou
authors.initials: S
authors.lastname: Lu
authors.affiliation: School of Chemistry and Environment, South China Normal University, Guangzhou, 510006, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Ren
authors.affiliation: School of Chemistry and Environment, South China Normal University, Guangzhou, 510006, China.
authors.forename: Jianzhang
authors.initials: J
authors.lastname: Fang
authors.affiliation: Shenzhen Centers for Disease Control and Prevention, Shenzhen, 518055, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Ji
authors.affiliation: Shenzhen Centers for Disease Control and Prevention, Shenzhen, 518055, China.
authors.forename: Guihua
authors.initials: G
authors.lastname: Liu
authors.affiliation: Shenzhen Centers for Disease Control and Prevention, Shenzhen, 518055, China.
authors.forename: Jianqing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Shenzhen Centers for Disease Control and Prevention, Shenzhen, 518055, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Shenzhen Centers for Disease Control and Prevention, Shenzhen, 518055, China.
authors.forename: Ruorong
authors.initials: R
authors.lastname: Luo
authors.affiliation: Shenzhen Centers for Disease Control and Prevention, Shenzhen, 518055, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Lin
authors.affiliation: Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitor, School of Life Science, South China Normal University, Guangzhou, 510631, China. tgxb@jnu.edu.cn.
authors.forename: Ruifang
authors.initials: R
authors.lastname: Fan
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D001151:Arsenic / Q000032:analysis / Q000652:urine; D015415:Biomarkers / Q000652:urine; D002104:Cadmium / Q000032:analysis / Q000652:urine; D002681:China; D002853:Chromatography, Liquid; D003300:Copper / Q000032:analysis / Q000652:urine; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity* / Q000652:urine; D005260:Female; D006801:Humans; D008345:Manganese / Q000032:analysis / Q000652:urine; D009532:Nickel / Q000032:analysis / Q000652:urine; D012643:Selenium / Q000032:analysis / Q000652:urine; D013057:Spectrum Analysis; D013334:Students; D053719:Tandem Mass Spectrometry; D014131:Trace Elements / Q000032:analysis / Q000633:toxicity* / Q000652:urine
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D014131:Trace Elements; D002104:Cadmium; D008345:Manganese; D003300:Copper; D009532:Nickel; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D012643:Selenium; D001151:Arsenic
keywords: 8-hydroxy-2′-deoxyguanosine; Oxidative stress; Trace elements; Urine