title: The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals.
abstract: The conventional view is that female mammals lose their ability to generate new germ cells after birth. However, in recent years, researchers have successfully isolated and cultured a type of germ cell from postnatal ovaries in a variety of mammalian species that have the abilities of self-proliferation and differentiation into oocytes, and this finding indicates that putative germline stem cells maybe exist in the postnatal mammalian ovaries. Herein, we review the research history and discovery of putative female germline stem cells, the concept that putative germline stem cells exist in the postnatal mammalian ovary, and the research progress, challenge, and application of putative germline stem cells in recent years.
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; Faculty of Basic Medical Science, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
authors.forename: Zezheng
authors.initials: Z
authors.lastname: Pan
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; College of Life Science, Chinese PLA General Hospital, Beijing 100039, China.
authors.forename: Mengli
authors.initials: M
authors.lastname: Sun
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Liang
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
authors.forename: Fangyue
authors.initials: F
authors.lastname: Zhou
authors.affiliation: The Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang 330006, China.
authors.forename: Zhisheng
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
authors.forename: Yuehui
authors.initials: Y
authors.lastname: Zheng