title: Investigating clinical predictors of arteriovenous fistula functional patency in a European cohort.
abstract: BACKGROUND
  Arteriovenous fistula (AVF) failure to mature (FTM) rates contribute to excessive dependence on central venous catheters for haemodialysis. Choosing the most appropriate vascular access site for an individual patient is guided largely by their age, co-morbidities and clinical examination. We investigated the clinical predictors of AVF FTM in a European cohort of patients and applied an existing clinical risk prediction model for AVF FTM to this population.
  
  
  METHODS
  A prospective cohort study was designed that included all patients undergoing AVF creation between January 2009 and December 2014 in a single centre (Belfast City Hospital) who had a functional AVF outcome observed by March 2015.
  
  
  RESULTS
  A total of 525 patients had a functional AVF outcome recorded and were included in the FTM analysis. In this cohort, 309 (59%) patients achieved functional AVF patency and 216 (41%) patients had FTM. Female gender [P < 0.001, odds ratio (OR) 2.03 (CI 1.37-3.02)] and lower-arm AVF [P < 0.001, OR 4.07 (CI 2.77-5.92)] were associated with AVF FTM. The Lok model did not predict FTM outcomes based on the associated risk stratification in our population.
  
  
  CONCLUSIONS
  In this European study, female gender was associated with twice the risk of AVF FTM and a lower-arm AVF with four times the risk of FTM. The FTM risk prediction model was not found to be discriminative in this population. Clinical risk factors for AVF FTM vary between populations; we would recommend that units investigate their own clinical predictors of FTM to maximize AVF functional patency and ultimately survival in dialysis patients. Clinical predictors of AVF FTM may not be sufficient on their own to improve vascular access functional patency rates.
authors.affiliation: Regional Nephrology Unit, Belfast City Hospital, Belfast, UK; Nephrology Research Group, Centre for Public Health, Queen's University Belfast, Royal Victoria Hospital, Belfast, UK.
authors.forename: Agnes
authors.initials: A
authors.lastname: Masengu
authors.affiliation: Regional Nephrology Unit, Belfast City Hospital, Belfast, UK; Nephrology Research Group, Centre for Public Health, Queen's University Belfast, Royal Victoria Hospital, Belfast, UK.
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Maxwell
authors.affiliation: Regional Nephrology Unit , Belfast City Hospital , Belfast , UK.
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: Hanko
keywords: arteriovenous fistula; dialysis; failure to mature; vascular access