title: Prevalence of osteoporosis and vitamin D receptor gene polymorphisms (FokI) in an Iranian general population based study (Kurdistan) (IMOS).
abstract: BACKGROUND
  Osteoporosis, or porous bone, is a disease characterized by low bone mass density (BMD) and structural deterioration of bone tissue, leading to bone fragility and increased risk of hip, spine, and wrist fractures. There are numerous risk factors for osteoporosis. While many of these factors are non-genetic in nature, there is a definite genetic component responsible for this condition. The main aim of this study was to evaluate the association between VDR (Vitamin D receptor gene) polymorphisms (Fok1) A>G (rs2228570) and bone mineral density in an Iranian defined population.
  
  
  METHODS
  The study participants comprised of 1032 Iranians recruited from the city of Sanandaj during IMOS (Iranian Multi Center Osteoporosis Study). Bone mineral density measurement was performed in all the participants with and without osteoporosis. All samples were genotyped for VDR genes (Fok1) polymorphism with polymerase chain reaction, using a predesigned TaqMan allele discrimination assay.
  
  
  RESULTS
  There was a significant association between Fok1 polymorphism and osteoporosis in postmenopausal women, 0.138 (0.025-0.768).
  
  
  CONCLUSIONS
  It seems that cohort studies, which are more powerful than case-control studies, can be useful in evaluating the roles of genetic variants as risk or protective factors for osteoporosis.
authors.affiliation: MSc in Genetics, Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Mimina_13@yahoo.com.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Mohammadi
authors.affiliation: MD, PhD in Epidemiology, Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. abkeshtkar@gmail.com.
authors.forename: Abbasali
authors.initials: A
authors.lastname: Keshtkar
authors.affiliation: PhD Student in Biomaterials Medical Engineer, Biomedical Engineering Department, Maziar University, Rouyan, Iran. F.fba.te@gmail.com.
authors.forename: Fateme
authors.initials: F
authors.lastname: Fayyazbakhsh
authors.affiliation: MD, Endocrinologist, Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. M_ebrahimi49@yahoo.com.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ebrahimi
authors.affiliation: MD, PhD in Immune Genetics, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. mahsaamoli@hotmail.com.
authors.forename: Mahsa M
authors.initials: MM
authors.lastname: Amoli
authors.affiliation: PhD in Epidemiology, Alborz University of Medical Sciences, Karaj, Iran. mqorbani1379@yahoo.com.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Ghorbani
authors.affiliation: PhD Student in Bio Nanotechnology , Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Patricia.kh@gmail.com.
authors.forename: Patricia
authors.initials: P
authors.lastname: Khashayar
authors.affiliation: MD, MPH, Non-communicable Disease Department, Iran Ministry of Health and Medical Education, Tehran, Iran. drmahdin@yahoo.com .
authors.forename: Mahboubeh
authors.initials: M
authors.lastname: Dini
authors.affiliation: PhD in Biochemistry, Biochemistry Department, Pasteur Institute of Iran, Tehran, Iran. minebrad@yahoo.com.
authors.forename: Mina
authors.initials: M
authors.lastname: Ebrahimi-Rad
authors.affiliation: MD, Endocrinologist, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
keywords: Bone Mineral Density; Fok1; Osteoporosis; Vitamin D Receptor Gene