title: [Pulmonary sarcomatoid carcinoma].
abstract: Pulmonary sarcomatoid carcinomas are a rare group of tumors accounting for about one percent of non-small cell lung carcinoma (NSCLC). In 2015, the World Health Organization classification united under this name all the carcinomas with sarcomatous-like component with spindle cell or giant cell appearance, or associated with a sarcomatous component sometimes heterologous. There are five subtypes: pleomorphic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma and pulmonary blastoma. Clinical characteristics are not specific from the other subtypes of NSCLC. Epithelial to mesenchymal transition pathway may play a key role. Patients, usually tobacco smokers, are frequently symptomatic. Tumors are voluminous more often peripherical than central, with strong fixation on FDG TEP CT. Distant metastases are frequent with atypical visceral locations. These tumors have poorer prognosis than the other NSCLC subtypes because of great aggressivity, and frequent chemoresistance. Here we present pathological description and a review of literature with molecular features in order to better describe these tumors and perhaps introduce new therapeutics.
authors.affiliation: Service d'anatomie pathologique, hôpital Tenon, AP-HP, 4, rue de la Chine, 75970 Paris cedex 20, France; ER2 et GRC theranoscan, faculté de médecine Pierre-et-Marie-Curie, université Paris 6, 91-105, boulevard de l'Hôpital, 75013 Paris, France. Electronic address: martine.antoine@aphp.fr.
authors.forename: Martine
authors.initials: M
authors.lastname: Antoine
authors.affiliation: Service de pneumologie et réanimation, hôpital Tenon, 75970 Paris cedex 20, France; ER2 et GRC theranoscan, faculté de médecine Pierre-et-Marie-Curie, université Paris 6, 91-105, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Thibault
authors.initials: T
authors.lastname: Vieira
authors.affiliation: Service de pneumologie et réanimation, hôpital Tenon, 75970 Paris cedex 20, France; ER2 et GRC theranoscan, faculté de médecine Pierre-et-Marie-Curie, université Paris 6, 91-105, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Fallet
authors.affiliation: ER2 et GRC theranoscan, faculté de médecine Pierre-et-Marie-Curie, université Paris 6, 91-105, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Hamard
authors.affiliation: ER2 et GRC theranoscan, faculté de médecine Pierre-et-Marie-Curie, université Paris 6, 91-105, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Duruisseaux
authors.affiliation: Service de pneumologie et réanimation, hôpital Tenon, 75970 Paris cedex 20, France; ER2 et GRC theranoscan, faculté de médecine Pierre-et-Marie-Curie, université Paris 6, 91-105, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Cadranel
authors.affiliation: Service de pneumologie et réanimation, hôpital Tenon, 75970 Paris cedex 20, France; ER2 et GRC theranoscan, faculté de médecine Pierre-et-Marie-Curie, université Paris 6, 91-105, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Wislez
mesh_terms: D014408:Biomarkers, Tumor; D002277:Carcinoma / Q000737:chemistry / Q000145:classification* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000145:classification* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor
keywords: Biologie moléculaire/Carcinome bronchique non à petite cellule; Carcinome bronchique non à petite cellule; Carcinomes sarcomatoïdes; Epithelial to mesenchymal transition; Molecular biology/non-small cell carcinoma; Non-small cell carcinoma; Sarcomatoid carcinoma; Therapy/non-small cell carcinoma; Traitement/Carcinome bronchique non à petite cellule; Transition épithélio-mésenchymateuse