title: A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo.
abstract: A novel near-infrared (NIR), turn-on fluorescence probe containing a phosphinate group as a recognizing moiety for the selective detection of O2˙(-) with a low limit of detection (LOD, 9.9 nM) was developed. has good cell-membrane permeability, intracellular stability, and low cytotoxicity. In addition, we successfully applied the to visualize O2˙(-) in live zebrafish, mouse and, for the first time, in mouse liver.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. zhanghx@lzu.edu.cn.
authors.forename: Jianjian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China.
authors.forename: Chuwen
authors.initials: C
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. zhanghx@lzu.edu.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. zhanghx@lzu.edu.cn.
authors.forename: Fengyuan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. zhanghx@lzu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. zhanghx@lzu.edu.cn.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China.
authors.forename: Simon Ming-Yuen
authors.initials: SM
authors.lastname: Lee
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. zhanghx@lzu.edu.cn.
authors.forename: Haixia
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005456:Fluorescent Dyes / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D066298:In Vitro Techniques; D007259:Infrared Rays; D057230:Limit of Detection; D051379:Mice; D010721:Phosphinic Acids / Q000737:chemistry*; D013481:Superoxides / Q000032:analysis*; D015027:Zebrafish
chemical_list: D005456:Fluorescent Dyes; D010721:Phosphinic Acids; D013481:Superoxides