title: Renal Transplantation in the Setting of Prior Urinary Diversion: A Case of Poorly Differentiated Adenocarcinoma in an Ileal Conduit.
abstract: Though rare, renal transplantation into a bowel containing urinary diversion is necessary in select clinical situations. Compared to renal transplant patients with functional native bladders, patients with urinary diversion have comparable long-term graft and patient survival rates. However, compounding the increased risk of malignancy in those on chronic immunosuppression are the inherent risks of urinary diversion. We present a case report of a high grade adenocarcinoma with neuroendocrine differentiation arising in an ileal conduit and discussion on the pathophysiology, management, and screening of this highly select population.
authors.affiliation: Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Matulewicz
authors.affiliation: Department of Surgery, Kovler Organ Transplantation Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Fryer
authors.affiliation: Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: X J
authors.initials: XJ
authors.lastname: Yang
authors.affiliation: Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: R
authors.initials: R
authors.lastname: Goyal
authors.affiliation: Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Hairston
keywords: Cystectomy; Ileal conduit; Neuroendocrine tumor; Urinary diversion