title: Role of Surveillance Imaging in Patients With Peripheral T-Cell Lymphoma.
abstract: BACKGROUND
  The role of surveillance imaging (SI) in patients with peripheral T-cell lymphoma (PTCL) in first complete remission (CR1) is unclear.
  
  
  METHODS
  Patients with PTCL were identified through prospectively maintained T-cell lymphoma databases from the National Cancer Centre Singapore/Singapore General Hospital and Weill-Cornell Medical College after institutional review board approval. Patients with leukemia or indolent, composite, and cutaneous lymphomas were excluded. The patients' medical records were retrospectively reviewed to determine the frequency and type of SI used. Of those with relapse, the method of relapse detection and data on symptoms, signs, and elevated lactate dehydrogenase LDH were extracted.
  
  
  RESULTS
  A total of 338 patients were included in the present study. In the first year after achieving CR1, patients had an average of 1.2 and a median of 1 SI performed (range, 0-4). In the second year after achieving CR1, they had an average of 0.78 and a median of 1 SI performed (range, 0-4). Of the 135 patients who achieved CR1, 61 (45%) developed a relapse. Relapses were detected before SI in 48 (84%), and 9 patients had relapses detected during routine SI. Of the 9 patients whose relapses were detected during planned SI, only 3 did not have any symptoms or signs suggestive of relapsed disease. Of these 3 patients, 2 had angioimmunoblastic T-cell lymphoma and 1 had natural killer/T-cell lymphoma.
  
  
  CONCLUSIONS
  Most PTCL relapses were detected before planned SI, and most patients had symptoms with relapse. Only 3 patients (5.2%) were completely asymptomatic at relapse, suggesting a limited utility of routine imaging for detecting PTCL relapses.
authors.affiliation: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY. Electronic address: Tiffany.Tang.P.L@nccs.com.sg.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Tang
authors.affiliation: Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, NY.
authors.forename: Zhengming
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY.
authors.forename: Pannee
authors.initials: P
authors.lastname: Praditsuktavorn
authors.affiliation: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
authors.forename: Lay Poh
authors.initials: LP
authors.lastname: Khoo
authors.affiliation: Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY.
authors.forename: Jia
authors.initials: J
authors.lastname: Ruan
authors.affiliation: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
authors.forename: Soon Thye
authors.initials: ST
authors.lastname: Lim
authors.affiliation: Department of Hematology, Singapore General Hospital, Singapore, Singapore.
authors.forename: Daryl
authors.initials: D
authors.lastname: Tan
authors.affiliation: Department of Hematology, Singapore General Hospital, Singapore, Singapore.
authors.forename: Colin
authors.initials: C
authors.lastname: Phipps
authors.affiliation: Department of Hematology, Singapore General Hospital, Singapore, Singapore.
authors.forename: Yuh Shan
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Department of Hematology, Singapore General Hospital, Singapore, Singapore.
authors.forename: Yeow Tee
authors.initials: YT
authors.lastname: Goh
authors.affiliation: Department of Hematology, Singapore General Hospital, Singapore, Singapore.
authors.forename: William
authors.initials: W
authors.lastname: Hwang
authors.affiliation: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
authors.forename: Miriam
authors.initials: M
authors.lastname: Tao
authors.affiliation: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
authors.forename: Richard
authors.initials: R
authors.lastname: Quek
authors.affiliation: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Farid
authors.affiliation: Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY.
authors.forename: Richard R
authors.initials: RR
authors.lastname: Furman
authors.affiliation: Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY.
authors.forename: John P
authors.initials: JP
authors.lastname: Leonard
authors.affiliation: Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY.
authors.forename: Peter
authors.initials: P
authors.lastname: Martin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome; D057832:Watchful Waiting; D055815:Young Adult
keywords: Imaging; Lymphoma; Peripheral; Surveillance; T cell