title: KRAS, HRAS and EGFR Mutations in Sporadic Sebaceous Gland Hyperplasia.
abstract: Sporadic sebaceous gland hyperplasia (SGH) is a benign skin lesion, with a high prevalence in the general population. Although SGH has been attributed to both extrinsic and intrinsic factors, the underlying genetic changes have not yet been characterized. Recently, HRAS and KRAS mutations have been identified in sebaceous naevus, a hamartoma sharing histological characteristics with SGH. Therefore we screened 43 SGH for activating mutations in RAS genes and other oncogenes. We identified a wide spectrum of mutually exclusive activating HRAS (8/43), KRAS (11/43) and EGFR mutations (7/31) in altogether 60% of the lesions investigated. A RAS and EGFR wildtype status was found in 15 normal sebaceous glands in the head and neck area. Our findings indicate that activating HRAS, KRAS and EGFR mutations play a major role in the pathogenesis of sporadic SGH. These results support the concept that SGH is a true benign neoplasm rather than a reactive hyperplasia.
authors.affiliation: Department of Dermatology, University of Regensburg, DE-93053 Regensburg, Germany. leopold.groesser@ukr.de.
authors.forename: Leopold
authors.initials: L
authors.lastname: Groesser
authors.forename: Sebastian
authors.initials: S
authors.lastname: Singer
authors.forename: Eva
authors.initials: E
authors.lastname: Peterhof
authors.forename: Michael
authors.initials: M
authors.lastname: Landthaler
authors.forename: Ulrike
authors.initials: U
authors.lastname: Heigl
authors.forename: Wulf
authors.initials: W
authors.lastname: Schneider-Brachert
authors.forename: Mark
authors.initials: M
authors.lastname: Berneburg
authors.forename: Christian
authors.initials: C
authors.lastname: Hafner
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D004252:DNA Mutational Analysis; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D011905:Genes, ras / Q000235:genetics; D006257:Head; D006801:Humans; D006965:Hyperplasia / Q000235:genetics; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009333:Neck; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D012625:Sebaceous Gland Diseases / Q000235:genetics*; D012627:Sebaceous Glands / Q000378:metabolism*
chemical_list: C117307:KRAS protein, human; C512478:EGFR protein, human; D066246:ErbB Receptors; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)