title: Biomarkers of vascular dysfunction and cognitive decline in patients with Alzheimer's disease: no evidence for association in elderly subjects.
abstract: BACKGROUND
  Several studies have suggested that vascular dysfunction plays an important role in Alzheimer's disease.
  
  
  OBJECTIVE
  We hypothesized that significant differences might be observed in the levels of blood endothelial biomarkers across elderly population of subjects with dementia.
  
  
  METHODS
  We analyzed, in a prospective monocentric study, three different endothelial biomarkers, endothelial microparticles (EMPs), endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in 132 older patients who underwent a full evaluation of a memory complaint.
  
  
  RESULTS
  There was no difference in specific EMP, EPC or CEC levels between demented or non-demented patients, nor considering cognitive decline.
  
  
  CONCLUSIONS
  Blood endothelial biomarkers may be too sensitive and it is likely that the multimorbidity observed in our patients may lead to opposite and confounding effects on endothelial biomarkers levels.
  
  
  CONCLUSIONS
  Unlike younger AD patients, our results suggest that endothelial biomarkers are not valuable for the diagnosis of dementia in elderly patients.
authors.affiliation: Centre de Gériatrie, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, APHP, DHU FAST, 75013, Paris, France. alice.breining@aphp.fr.|Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR 8256 B2A, 75005, Paris, France. alice.breining@aphp.fr.
authors.forename: Alice
authors.initials: A
authors.lastname: Breining
authors.affiliation: INSERM, U970, Paris Cardiovascular Research Center-PARCC, Université Paris Descartes, Sorbonne Paris Cité, UMR-S970, Paris, France.
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Silvestre
authors.affiliation: Centre de Gériatrie, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, APHP, DHU FAST, 75013, Paris, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Dieudonné
authors.affiliation: INSERM, U970, Paris Cardiovascular Research Center-PARCC, Université Paris Descartes, Sorbonne Paris Cité, UMR-S970, Paris, France.
authors.forename: José
authors.initials: J
authors.lastname: Vilar
authors.affiliation: Centre de Gériatrie, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, APHP, DHU FAST, 75013, Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Faucounau
authors.affiliation: Centre de Gériatrie, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, APHP, DHU FAST, 75013, Paris, France.|Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR 8256 B2A, 75005, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Verny
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR 8256 B2A, 75005, Paris, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Néri
authors.affiliation: INSERM, U970, Paris Cardiovascular Research Center-PARCC, Université Paris Descartes, Sorbonne Paris Cité, UMR-S970, Paris, France.
authors.forename: Chantal M
authors.initials: CM
authors.lastname: Boulanger
authors.affiliation: Centre de Gériatrie, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, APHP, DHU FAST, 75013, Paris, France.|Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR 8256 B2A, 75005, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Boddaert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D042783:Endothelial Cells / Q000473:pathology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies
chemical_list: D015415:Biomarkers
keywords: Circulating endothelial cells; Dementia; Endothelial microparticles; Endothelial progenitors cells; Older population