title: Pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(IV)) complex.
abstract: The present study was designed to evaluate the pharmacokinetic (PK) properties of di-μ-hydroxo-bis(quercetinatooxovanadium(IV) (HOBQOV) complex, with hypoglycemic and hypolipidemic properties, in rats after a single i.p. dose of 100 mg/kg b.w. The HOBQOV complex pharmacokinetics is described by a bicompartmental model and the plasma concentration decrease is described by two phases that might be correlated to the distribution and elimination processes. The obtained results suggest a PK profile of the complex suitable for a profound distribution in the animal organism with possibility of interaction with the cytosolic enzymes.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy.
authors.forename: B S
authors.initials: BS
authors.lastname: Velescu
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Uivarosi
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy.
authors.forename: Anca
authors.initials: A
authors.lastname: Buzescu
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy.
authors.forename: I
authors.initials: I
authors.lastname: Sarbu
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Faculty of Dental Medicine.
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Ionescu
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Anuta
keywords: HOBQOV; HPLC; bicompartmental model; pharmacokinetics