title: [A Case of Rectal Cancer Completely Resected after Successful Treatment with Irinotecan plus Cetuximab-Induced Interstitial Pneumonia with Steroid Pulse Therapy].
abstract: We report of a 74-year-old man with advanced rectal cancer invading the small intestine and bladder. Initially, 3 courses of neoadjuvant chemotherapy with FOLFIRI and cetuximab were administered. At the beginning of the 4 course, the patient experienced fever and dyspnea. Chest radiography and computed tomography showed ground-grass opacities in both lungs. He was diagnosed with interstitial pneumonia induced by irinotecan or cetuximab. Steroid pulse therapy consisting of methyl-prednisolone (1,000 mg/day; 3 days) with respiratory assist resulted in significant improvement, and prednisolone was continued while reducing the dose gradually. He stopped the medicine on the 106th day from the first treatment, and underwent the R0 operation on the 113th day. We report for the first time a case of interstitial pneumonia occurring after neoadjuvant chemotherapy for advanced rectal cancer that was successfully resected after treatment.
authors.affiliation: Dept. of Surgery, Osaka National Hospital.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Miyake
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeda
authors.forename: Naotsugu
authors.initials: N
authors.lastname: Haraguchi
authors.forename: Mamoru
authors.initials: M
authors.lastname: Uemura
authors.forename: Masataka
authors.initials: M
authors.lastname: Ikeda
authors.forename: Michihiko
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Sakae
authors.initials: S
authors.lastname: Maeda
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Hama
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyamoto
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hirao
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakamori
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Sekimoto
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002166:Camptothecin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D000068818:Cetuximab / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D006801:Humans; D000077146:Irinotecan; D017563:Lung Diseases, Interstitial / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012503:Saponins / Q000627:therapeutic use*
chemical_list: D012503:Saponins; C516626:methyl-protodeltonin; D000077146:Irinotecan; D000068818:Cetuximab; D002166:Camptothecin