title: Synthesis and Some Reactions of 1-aryl-4-acetyl-5-methyl-1,2,3-triazole Derivatives with Anticonvulsant Activity.
abstract: The triazoles 3a-d underwent condensation reactions with 4-(piperidin-1-yl)-benzaldehyde to afford the chalcones 5a-d. Chalcone derivatives 5a-d were reacted with 2,3-diaminomaleonitrile, thiourea and hydrazine hydrate to afford the novel diazepine-dicarbonitrile derivatives 7a-d, the pyrimidine-2-thiol derivatives 9a-d and hydrazino-pyrimidines 10a-d respectively. Structures of the prepared compounds were elucidated by physical and spectral data like FT-IR, (1)H NMR, (13)C NMR, and mass spectroscopy. Some of the synthesized compounds were screened for their anticonvulsant activity and SAR.
authors.affiliation: Chemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, 11566 Cairo, Egypt. ekhlass_nassar@hotmail.com.
authors.forename: Ekhlass M
authors.initials: EM
authors.lastname: Nassar
authors.forename: Fathy M
authors.initials: FM
authors.lastname: Abdelrazek
authors.forename: Rezk R
authors.initials: RR
authors.lastname: Ayyad
authors.forename: Ahmed F
authors.initials: AF
authors.lastname: El-Farargy
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D008297:Male; D008745:Methylation; D051379:Mice; D012640:Seizures / Q000188:drug therapy*; D013010:Sonication / Q000379:methods; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D001381:Azepines; D047188:Chalcones; D014230:Triazoles