title: Cord Blood Transplantation Provided Long-term Remission in a Case of Adult T-cell Leukemia-lymphoma (ATL) with Myelofibrosis.
abstract: A 53-year-old man was diagnosed with adult T-cell leukemia-lymphoma (ATL) acute type transformed from chronic type. A bone marrow analysis showed diffuse infiltration of abnormal lymphocytes and diffuse fibrotic change. He received unrelated cord blood transplantation (CBT) following reduced-intensity conditioning with complete remission of ATL after two courses of chemotherapy and achieved neutrophil and platelet engraftment. At 99 days after CBT, a bone marrow biopsy showed apparent resolution of myelofibrosis. These results suggest the therapeutic potential of CBT for patients with chemosensitive ATL with myelofibrosis.
authors.affiliation: Department of Hematology, Sasebo City General Hospital, Japan.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Itonaga
authors.forename: Jun
authors.initials: J
authors.lastname: Taguchi
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kato
authors.forename: Shinya
authors.initials: S
authors.lastname: Sato
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sawayama
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Imaizumi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Niino
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hata
authors.forename: Takuya
authors.initials: T
authors.lastname: Fukushima
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyazaki
mesh_terms: D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000209:etiology*; D012074:Remission Induction