title: Biphasic Regulation of Lipid Metabolism: A Meta-Analysis of Icodextrin in Peritoneal Dialysis.
abstract: OBJECTIVE
  The objective of this systematic meta-analysis was to study the impact of icodextrin (ICO) on lipid profiles.
  
  
  METHODS
  MEDLINE, PubMed, Embase, Chinese Biomedical Literature, and the Cochrane Library and Reference lists were searched (last search September 2014) in accordance with the Cochrane Handbook for Systematic Reviews of Interventions.
  
  
  RESULTS
  Searches identified 13 eligible trials with a total of 850 patients. The differentials of total cholesterol (TC) and free fatty acid (FFA) in the ICO group were greater than those in the GLU group. Metaregression analysis showed that TC levels positively correlated with its baseline levels. In the subgroup of patients with dialysis duration more than 6 months, TC and TG in the ICO group were less. In pooled data from cross-sectional studies, differential of TG in the ICO group was less. In the subgroup of patients with diabetes (Martikainen et al., 2005, Sniderman et al., 2014, and Takatori et al., 2011), differential of high-density lipoprotein cholesterol (HDL-C) in the ICO group was less. There was no significant effect on low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), or lipoprotein(a).
  
  
  CONCLUSIONS
  ICO may be beneficial to lipid metabolism, especially for its biphasic regulation of plasma TC levels.
authors.affiliation: Department of Gastrointestinal Surgery, Shunde First People's Hospital Affiliated to Southern Medical University, Guangdong 528300, China.
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Huang
authors.affiliation: Department of Gastrointestinal Surgery, Shunde First People's Hospital Affiliated to Southern Medical University, Guangdong 528300, China.
authors.forename: Da-Jian
authors.initials: DJ
authors.lastname: Zhu
authors.affiliation: Department of Gastrointestinal Surgery, Shunde First People's Hospital Affiliated to Southern Medical University, Guangdong 528300, China.
authors.forename: Xiao-Wu
authors.initials: XW
authors.lastname: Chen
authors.affiliation: Department of Gastrointestinal Surgery, Shunde First People's Hospital Affiliated to Southern Medical University, Guangdong 528300, China.
authors.forename: Man-Zhao
authors.initials: MZ
authors.lastname: Ouyang
authors.affiliation: Department of Gastrointestinal Surgery, Shunde First People's Hospital Affiliated to Southern Medical University, Guangdong 528300, China.
authors.forename: Wei-Jie
authors.initials: WJ
authors.lastname: Zhang
mesh_terms: D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005936:Glucans / Q000627:therapeutic use*; D005947:Glucose / Q000627:therapeutic use*; D006801:Humans; D000077607:Icodextrin; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D010530:Peritoneal Dialysis; D014280:Triglycerides / Q000097:blood*
chemical_list: D008078:Cholesterol, LDL; D005936:Glucans; D008055:Lipids; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D000077607:Icodextrin; D005947:Glucose