title: [A Case of Brain Metastases from Pancreatic Cancer That Had Been Treated Effectively with FOLFIRINOX].
abstract: We report a case of multiple brain metastases from pancreatic cancer, which had responded remarkably to FOLFIRINOX. A 47-year-old man had hypovascular tumors, 25 mm on the body and 23 mm on the uncus of the pancreas; multiple liver metastases; and skin metastasis. A diagnosis of unresectable pancreatic cancer, cT4N3M1 (HEP, LYM, PUL, SKI), cStage Ⅳb was made. We chose FOLFIRINOX for treatment because of his young age and good performance status. After 6 courses, he showed decreasing tumor marker levels, an almost complete disappearance of the primary lesion, and reduced liver metastases. After 8 courses, abnormal behaviors were noted and we performed a head contrast-enhanced MRI, which revealed diffuse enhancement of the cerebral and cerebellar hemisphere. Multiple brain metastases from pancreatic cancer were diagnosed. We made the shift to palliative treatment, but his general condition was worsening and he died a month later, 7 months after the first diagnosis.
authors.affiliation: Dept. of Surgery, Shuuwa General Hospital.
authors.forename: Tomiyuki
authors.initials: T
authors.lastname: Miura
authors.forename: Noriaki
authors.initials: N
authors.lastname: Nakamura
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kurihara
authors.forename: Kouji
authors.initials: K
authors.lastname: Yonekura
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sanada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kuwabara
authors.forename: Narihide
authors.initials: N
authors.lastname: Goseki
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000601:surgery