title: Enhanced Classification of Interstitial Lung Disease Patterns in HRCT Images Using Differential Lacunarity.
abstract: The analysis and interpretation of high-resolution computed tomography (HRCT) images of the chest in the presence of interstitial lung disease (ILD) is a time-consuming task which requires experience. In this paper, a computer-aided diagnosis (CAD) scheme is proposed to assist radiologists in the differentiation of lung patterns associated with ILD and healthy lung parenchyma. Regions of interest were described by a set of texture attributes extracted using differential lacunarity (DLac) and classical methods of statistical texture analysis. The proposed strategy to compute DLac allowed a multiscale texture analysis, while maintaining sensitivity to small details. Support Vector Machines were employed to distinguish between lung patterns. Training and model selection were performed over a stratified 10-fold cross-validation (CV). Dimensional reduction was made based on stepwise regression (F-test, p value < 0.01) during CV. An accuracy of 95.8 ± 2.2% in the differentiation of normal lung pattern from ILD patterns and an overall accuracy of 94.5 ± 2.1% in a multiclass scenario revealed the potential of the proposed CAD in clinical practice. Experimental results showed that the performance of the CAD was improved by combining multiscale DLac with classical statistical texture analysis.
authors.affiliation: INESC TEC, Campus da FEUP, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; Coimbra Institute of Engineering, Polytechnic Institute of Coimbra, Rua Pedro Nunes, Quinta da Nora, 3030-199 Coimbra, Portugal.
authors.forename: Verónica
authors.initials: V
authors.lastname: Vasconcelos
authors.affiliation: INESC TEC, Campus da FEUP, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; School of Science and Technology, University of Trás-os-Montes e Alto Douro, Apartado 1013, 5001-801 Vila Real, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Barroso
authors.affiliation: Coimbra Institute of Engineering, Polytechnic Institute of Coimbra, Rua Pedro Nunes, Quinta da Nora, 3030-199 Coimbra, Portugal.
authors.forename: Luis
authors.initials: L
authors.lastname: Marques
authors.affiliation: Military Academy Research Center, Avenida Conde Castro Guimarães, 2720-113 Amadora, Portugal.
authors.forename: José Silvestre
authors.initials: JS
authors.lastname: Silva
mesh_terms: D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000000981:diagnostic imaging*; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging*; D008297:Male; D060388:Support Vector Machine; D014057:Tomography, X-Ray Computed