title: Primary Biliary Cirrhosis Overlapping with Autoimmune Hepatitis in an HIV-Infected Patient on Antiretroviral Therapy.
abstract: Liver disease in HIV-infected patients is complex and multifactorial. Drug toxicity and infections are common causes of elevations in liver-associated enzymes. Immune reconstitution and unmasking of autoimmune disease may also play a role, particularly in the era of effective combination antiretroviral therapy. In this case report, we describe the first reported biopsy-confirmed case of autoimmune hepatitis and primary biliary cirrhosis overlap syndrome presenting in an HIV-infected patient following initiation of antiretroviral therapy.
authors.affiliation: Clinical Research Directorate/CMRP, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Caplan
authors.affiliation: Liver Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
authors.forename: Apurva
authors.initials: A
authors.lastname: Trivedi
authors.affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: McLaughlin
authors.affiliation: Carl Vogel Center, Washington, DC; USA.
authors.forename: Annick
authors.initials: A
authors.lastname: Hebou
authors.affiliation: Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Kleiner
authors.affiliation: Liver Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
authors.forename: Theo
authors.initials: T
authors.lastname: Heller
authors.affiliation: Critical Care Medicine Department, NIH Clinical Center, Bethesda, MD, USA.
authors.forename: Caryn G
authors.initials: CG
authors.lastname: Morse
keywords: HIV; autoimmune hepatitis; immune reconstitution; liver biopsy; overlap syndrome