title: New-Onset Diabetes Mellitus With Exposure to Ledipasvir and Sofosbuvir.
abstract: The combination therapy of ledipasvir/sofosbuvir was approved by the Food and Drug Administration in 2014 for the treatment of chronic hepatitis C. Although hyperglycemia is not well known to occur with its use, we present 2 cases of new-onset diabetes mellitus and a review of the literature suggesting an adverse event association. In the first patient with HIV, we postulate that ledipasvir/sofosbuvir increased the levels of tenofovir and thereby potentiated hyperglycemia. In the second case of a patient with prediabetes, ledipasvir/sofosbuvir appeared to increase insulin resistance. A literature review further supported an association of hyperglycemia and the use of ledipasvir/sofosbuvir. Hence, clinicians should be cautious about worsening of glucose intolerance, and more studies are warranted to explore the underlying mechanism.
authors.affiliation: George Washington University Hospital, Washington, DC, USA.
authors.forename: Resmi
authors.initials: R
authors.lastname: Premji
authors.affiliation: George Washington University Hospital, Washington, DC, USA.
authors.forename: Nira
authors.initials: N
authors.lastname: Roopnarinesingh
authors.affiliation: VA Medical Center, Washington, DC, USA.
authors.forename: Nazia
authors.initials: N
authors.lastname: Qazi
authors.affiliation: VA Medical Center, Washington, DC, USA.
authors.forename: Eric S
authors.initials: ES
authors.lastname: Nylen
keywords: chronic hepatitis C; glucose intolerance; ledipasvir/sofosbuvir; new-onset diabetes mellitus