title: Comparison between whole-body MRI with diffusion-weighted imaging and PET/CT in staging newly diagnosed FDG-avid lymphomas.
abstract: OBJECTIVE
  To compare whole body-MRI (WB-MRI) with diffusion-weighted imaging and FDG-PET/CT in staging newly diagnosed FDG-avid lymphomas.
  
  
  METHODS
  68 patients (37 males, 31 females; median age 42 years; range 15-86 years) with histologically confirmed lymphoma (37 Classical Hodgkin, 16 Diffuse large B-cell, 10 Follicular, 5 Mantle cell) underwent both MRI and FDG-PET/CT before treatment. Ann Arbor stages obtained with WB-MRI and FDG-PET/CT were compared using Cohen's k statistics. Moreover WB-MRI and FDG-PET/CT stages were compared with the pathological stages obtained after the diagnostic iter using also bone marrow and available biopsies if clinically indicated.
  
  
  RESULTS
  The agreement between WB-MRI and FDG-PET/CT was excellent. WB-MRI stage was equal to those of FDG-PET/CT in 62/68 patients (91.2%). There was an excellent agreement between WB-MRI stage and pathological stage (63/68 patients; 92.6%), and between FDG-PET/CT and pathological stage (64/68 patients; 94.1%). The differences between the stages were more frequent in the patients with Mantle cell lymphoma.
  
  
  CONCLUSIONS
  WB-MRI can be considered as a promising technique for FDG-avid lymphoma staging.
authors.affiliation: Department of Radiology, University of Palermo, Via del Vespro 127, Palermo 90127, Italy. Electronic address: albanodomenico@me.com.
authors.forename: Domenico
authors.initials: D
authors.lastname: Albano
authors.affiliation: Department of Hematology I, Azienda Ospedali Riuniti Villa Sofia-Cervello, Viale Strasburgo 233, Palermo 90146, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Patti
authors.affiliation: Department of Radiology, University of Palermo, Via del Vespro 127, Palermo 90127, Italy.
authors.forename: Ludovico
authors.initials: L
authors.lastname: La Grutta
authors.affiliation: Department of Radiology, University of Palermo, Via del Vespro 127, Palermo 90127, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Agnello
authors.affiliation: Department of Radiology, University of Palermo, Via del Vespro 127, Palermo 90127, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Grassedonio
authors.affiliation: Department of Hematology I, Azienda Ospedali Riuniti Villa Sofia-Cervello, Viale Strasburgo 233, Palermo 90146, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Mulè
authors.affiliation: Department of Nuclear Medicine, Azienda Ospedali Riuniti Villa Sofia-Cervello, Viale Strasburgo 233, Palermo 90146, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Cannizzaro
authors.affiliation: Department of Nuclear Medicine, La Maddalena Hospital, Via San Lorenzo Colli 312/d, Palermo 90146, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Ficola
authors.affiliation: Department of Radiology, University of Palermo, Via del Vespro 127, Palermo 90127, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Lagalla
authors.affiliation: Department of Radiology, University of Palermo, Via del Vespro 127, Palermo 90127, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Midiri
authors.affiliation: Department of Radiology, University of Palermo, Via del Vespro 127, Palermo 90127, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Galia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007559:Ivermectin / Q000031:analogs & derivatives; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods*; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C048324:abamectin; D007559:Ivermectin
keywords: Computed tomography; Diffusion-weighted imaging; Lymphoma; Magnetic resonance imaging; Positron-emission tomography; Staging