title: Chronic lymphocytic leukemia: Time to go past genomics?
abstract: Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of interpatient and intratumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biological pathways, and to the modeling of CLL clonal evolution. We herein review selected aspects including recent advances in the biology of CLL and present cellular and biological processes involved in the development of CLL and potentially other mature B-cell lymphoproliferative neoplasms.
authors.affiliation: Institut National De La Santé Et De La Recherche Médicale (INSERM) U1170, Villejuif, France.|Gustave Roussy, Villejuif, France.|Université Paris Saclay, France.|Equipe Labellisée Ligue Nationale Contre Le Cancer.
authors.forename: Damien
authors.initials: D
authors.lastname: Roos-Weil
authors.affiliation: INSERM U1138, Paris, France.|Université Pierre Et Marie Curie-Paris 6, France.|Service D'hématologie Biologique, Hôpital Pitié-Salpêtrière, APHP, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Nguyen-Khac
authors.affiliation: Institut National De La Santé Et De La Recherche Médicale (INSERM) U1170, Villejuif, France.|Gustave Roussy, Villejuif, France.|Université Paris Saclay, France.|Equipe Labellisée Ligue Nationale Contre Le Cancer.
authors.forename: Olivier A
authors.initials: OA
authors.lastname: Bernard
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations; D002999:Clone Cells; D019175:DNA Methylation; D018450:Disease Progression; D019143:Evolution, Molecular; D005544:Forecasting; D005803:Genes, Immunoglobulin; D052138:Genes, Neoplasm; D018740:Genetic Heterogeneity; D023281:Genomics; D042421:Histone Code; D006801:Humans; D007942:Leukemia, Experimental / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000473:pathology; D051379:Mice; D008957:Models, Genetic; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology; D010265:Paraproteinemias / Q000235:genetics / Q000473:pathology; D015398:Signal Transduction / Q000235:genetics
chemical_list: D009363:Neoplasm Proteins