title: Selenium-containing organic nanoparticles as silent precursors for ultra-sensitive thiol-responsive transmembrane anion transport.
abstract: An anion transporter with a selenoxide group was able to form nanoparticles in water, whose activity was fully turned off due to the aggregation effect. The formed nanoparticles have a uniform size and can be readily dispersed in water at high concentrations. Turn-on of the nanoparticles by reducing molecules is proposed to be a combined process, including the reduction of selenoxide to selenide, disassembly of the nanoparticles and location of the transporter to the lipid membrane. Accordingly, a special acceleration phase can be observed in the turn-on kinetic curves. Since turn-on of the nanoparticles is quantitatively related to the amount of reductant, the nanoparticles can be activated in a step-by-step manner. Due to the sensibility of this system to thiols, cysteine can be detected at low nanomolar concentrations. This ultra-sensitive thiol-responsive transmembrane anion transport system is quite promising in biological applications.
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. junqiuliu@jlu.edu.cn.
authors.forename: Chao
authors.initials: C
authors.lastname: Lang
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. junqiuliu@jlu.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. junqiuliu@jlu.edu.cn.
authors.forename: Zeyuan
authors.initials: Z
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. junqiuliu@jlu.edu.cn.
authors.forename: Quan
authors.initials: Q
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. junqiuliu@jlu.edu.cn.
authors.forename: Shanpeng
authors.initials: S
authors.lastname: Qiao
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. junqiuliu@jlu.edu.cn.
authors.forename: Zupeng
authors.initials: Z
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. junqiuliu@jlu.edu.cn.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. junqiuliu@jlu.edu.cn.
authors.forename: Jiayun
authors.initials: J
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. junqiuliu@jlu.edu.cn.
authors.forename: Junqiu
authors.initials: J
authors.lastname: Liu
mesh_terms: D000838:Anions / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012643:Selenium / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D053835:Unilamellar Liposomes / Q000737:chemistry / Q000378:metabolism
chemical_list: D000838:Anions; D013438:Sulfhydryl Compounds; D053835:Unilamellar Liposomes; D012643:Selenium