title: Physiological and pathological impact of exosomes of adipose tissue.
abstract: Exosomes are nanovesicles that have emerged as a new intercellular communication system for transporting proteins and RNAs; recent studies have shown that they play a role in many physiological and pathological processes such as immune regulation, cell differentiation, infection and cancer. By transferring proteins, mRNAs and microRNAs, exosomes act as information vehicles that alter the behavior of recipient cells. Compared to direct cell-cell contact or secreted factors, exosomes can affect recipient cells in more efficient ways. In whole adipose tissues, it has been shown that exosomes exist in supernatants of adipocytes and adipose stromal cells (ADSCs). Adipocyte exosomes are linked to lipid metabolism and obesity-related insulin resistance and exosomes secreted by ADSCs are involved in angiogenesis, immunomodulation and tumor development. This review introduces characteristics of exosomes in adipose tissue, summarizes their functions in different physiological and pathological processes and provides the further insight into potential application of exosomes to disease diagnosis and treatment.
authors.affiliation: State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, China.|National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.|Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, China.|National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Mei
authors.identifier: http://orcid.org/0000-0003-0306-6817
authors.initials: M
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, China.|National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.|Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Tian
mesh_terms: D000273:Adipose Tissue / Q000473:pathology* / Q000503:physiopathology*; D000818:Animals; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological