title: Tuberculosis treatment outcomes among peri-urban children receiving doorstep tuberculosis care.
abstract: OBJECTIVE
  To determine the optimal tuberculosis (TB) management strategy for children living in peri-urban, resource-limited settings.
  
  
  METHODS
  We compared TB treatment outcomes among children aged 0-15 years receiving doorstep care (n = 82) with those of a historical group (n = 97) receiving clinic-based care.
  
  
  RESULTS
  The doorstep care and clinic-based groups had similar age and sex profiles; treatment default rates were 3.7% (3/82) vs. 38.1% (37/97, P < 0.0001), treatment completion rates were 65.9% (54/82) vs. 51.6% (50/97, P = 0.01), and cure rates were 13.4% (11/82) vs. 2.1% (2/97), respectively (P < 0.0001).
  
  
  CONCLUSIONS
  Children living in peri-urban communities had improved TB treatment outcomes with doorstep care.
authors.affiliation: Centre for the AIDS Programme of Research in South Africa (CAPRISA), South Africa.
authors.forename: L
authors.initials: L
authors.lastname: Jeena
authors.affiliation: Centre for the AIDS Programme of Research in South Africa (CAPRISA), South Africa; Medical Research Council CAPRISA HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: K
authors.initials: K
authors.lastname: Naidoo
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003695:Delivery of Health Care; D005260:Female; D006699:Home Care Services; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D055118:Medication Adherence; D012074:Remission Induction; D012189:Retrospective Studies; D013019:South Africa; D013997:Time Factors; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D019037:Urban Health Services
chemical_list: D000995:Antitubercular Agents