title: Involvement of F-box proteins in esophageal cancer (Review).
abstract: The F-box proteins (FBPs) in esophageal tumorigenesis are pivotal as they govern a broad array of basic physiological responses including cell growth, cell death and DNA damage repair. Esophageal cancer (EC) is a common and highly aggressive cancer worldwide. Aberrant stabilization of crucial proteins participates in esophageal tumorigenesis. Recently, growing evidence has shown that FBPs play a critical role in oncogenesis, invasion, metastasis and prognosis assessment of EC. In this review we summarized published data on the roles of known FBPs, their respective substrates and the key signaling pathways, in the development of EC, aiming to uncover new ways for the rational design of targeted therapies in EC.
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Gong
authors.affiliation: Department of Spine Surgery, Shenzhen Nanshan Hospital of Guangdong Medical College, Shenzhen, Guangdong 510282, P.R. China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Ji-Rong
authors.initials: JR
authors.lastname: Huo
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002384:Catalysis; D049109:Cell Proliferation; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000628:therapy*; D044783:F-Box Proteins / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis; D011379:Prognosis; D046988:Proteasome Endopeptidase Complex / Q000502:physiology; D015398:Signal Transduction; D025801:Ubiquitin / Q000502:physiology; D054875:Ubiquitination
chemical_list: D014408:Biomarkers, Tumor; D044783:F-Box Proteins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex