title: Evaluation of the psychometric properties of the PROMIS Cancer Fatigue Short Form with cancer patients.
abstract: OBJECTIVE
  Fatigue is common among cancer patients and adversely impacts quality of life. As such, it is important to measure fatigue accurately in a way that is not burdensome to patients. The 7-item Patient Reported Outcome Measurement Information System (PROMIS) Cancer Fatigue Short Form scale was recently developed using item response theory (IRT). The current study evaluated the psychometric properties of this scale in two samples of cancer patients using classical test theory (CTT).
  
  
  METHODS
  Two samples were used: 121 men with prostate cancer and 136 patients scheduled to undergo hematopoietic cell transplantation (HCT) for hematologic cancer. All participants completed the PROMIS Cancer Fatigue Short Form as well as validated measures of fatigue, vitality, and depression. HCT patients also completed measures of anxiety, perceived stress, and a clinical interview designed to identify cases of cancer-related fatigue.
  
  
  RESULTS
  PROMIS Cancer Fatigue Short Form items loaded on a single factor (CFI=0.948) and the scale demonstrated good internal consistency reliability in both samples (Cronbach's alphas>0.86). Correlations with psychosocial measures were significant (p values<.0001) and in the expected direction, offering evidence for convergent and concurrent validity. PROMIS Fatigue scores were significantly higher in patients who met case definition criteria for cancer-related fatigue (p<.0001), demonstrating criterion validity.
  
  
  CONCLUSIONS
  The current study provides evidence that the PROMIS Cancer Fatigue Short Form is a reliable and valid measure of fatigue in cancer patients.
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, United States; University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, United States. Electronic address: jmcessna@mail.usf.edu.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Cessna
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, United States.
authors.forename: Heather S L
authors.initials: HS
authors.lastname: Jim
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, United States; University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, United States.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Sutton
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, United States; University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, United States.
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Asvat
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, United States; University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, United States.
authors.forename: Brent J
authors.initials: BJ
authors.lastname: Small
authors.affiliation: Northwestern University Feinberg School of Medicine, 633 N. St Clair, Suite 19-057, Chicago, IL 60611, United States; The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, United States.
authors.forename: John M
authors.initials: JM
authors.lastname: Salsman
authors.affiliation: James A. Haley Veterans Affairs Hospital, 13000 Bruce B. Downs Blvd., Tampa, FL 33612, United States.
authors.forename: Babu
authors.initials: B
authors.lastname: Zachariah
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, United States.
authors.forename: Mayer
authors.initials: M
authors.lastname: Fishman
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, United States.
authors.forename: Teresa
authors.initials: T
authors.lastname: Field
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, United States.
authors.forename: Hugo
authors.initials: H
authors.lastname: Fernandez
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, United States.
authors.forename: Lia
authors.initials: L
authors.lastname: Perez
authors.affiliation: Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, United States.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Jacobsen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000209:etiology; D003863:Depression / Q000209:etiology; D005221:Fatigue / Q000209:etiology*; D005260:Female; D006801:Humans; D007256:Information Systems; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D057566:Self Report / Q000592:standards; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology; D013315:Stress, Psychological / Q000209:etiology; D011795:Surveys and Questionnaires / Q000592:standards*
keywords: Cancer; Fatigue; PROMIS; Patient-reported outcomes; Psychometrics