title: The change tendency of PI3K/Akt pathway after spinal cord injury.
abstract: Spinal cord injury (SCI) refers to the damage of spinal cord's structure and function due to a variety of causes. At present, many scholars have confirmed that apoptosis is the main method of secondary injury in spinal cord injury. In view of understanding the function of PI3K/Akt pathway on spinal cord injury, this study observed the temporal variation of key molecules (PI3K, Akt, p-Akt) in the PI3K/Akt pathway after spinal cord injury by immunohistochemistry and Western-blot. The results showed that the expression of PI3K, Akt and p-Akt display a sharp increase one day after the spinal cord injury, and then it decreased gradually with the time passing by, but the absolute expression was certainly higher than the normal group. These results indicate that the PI3K/Akt signaling pathway is involved in the spinal cord injury and the mechanism may be related to apoptosis.
authors.affiliation: Department of Orthopedics and Traumatology, Peking University People's Hospital Beijing, China.
authors.forename: Peixun
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Institute of Human Anatomy and Histology and Embryology, Otology and Neuroscience Center, Binzhou Medical University Yantai, China.
authors.forename: Luping
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Hand and Foot Surgery, Qilu Hospital of Shandong University Shandong, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Orthopaedics, The Affiliated Yantai Hospital of Binzhou Medical University Yantai, China.
authors.forename: Fangmin
authors.initials: F
authors.lastname: Chen
authors.affiliation: Institute of Human Anatomy and Histology and Embryology, Otology and Neuroscience Center, Binzhou Medical University Yantai, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Institute of Human Anatomy and Histology and Embryology, Otology and Neuroscience Center, Binzhou Medical University Yantai, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Tian
authors.affiliation: Institute of Human Anatomy and Histology and Embryology, Otology and Neuroscience Center, Binzhou Medical University Yantai, China.
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, The Affiliated Yantai Hospital of Binzhou Medical University Yantai, China.
authors.forename: Xiaorui
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Institute of Genetics, College of Life Sciences, Zhejiang University Zhejiang, China.
authors.forename: Xuekun
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, The Affiliated Yantai Hospital of Binzhou Medical University Yantai, China.
authors.forename: Chuansen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, The Affiliated Yantai Hospital of Binzhou Medical University Yantai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Institute of Human Anatomy and Histology and Embryology, Otology and Neuroscience Center, Binzhou Medical University Yantai, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Huang
keywords: Akt; PI3K; Spinal cord injury; apoptosis