title: Intracellular pathogens convert macrophages from death traps into hospitable homes.
abstract: Intracellular pathogens - bacteria, parasites and fungi - frequently infect macrophages in addition to other cells. They turn these deadly cells into harmless hosts to multiply and paralyze immunity. Understanding the complex mechanisms underlying this phenomenon may have a strong impact to identify new targets belonging to the pathogens but also to the host, thereby allowing the design of new therapeutic strategies.
authors.affiliation: CEA, Section of Molecular Engineering of Proteins (SIMOPRO), Institute of Biology and Biotechnology of Saclay (iBiTec-S), LERMIT LabEx, Paris Saclay University, Gif sur Yvette, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Barbier
authors.affiliation: CEA, Section of Bioorganic Chemistry and Labelling (SCBM), Institute of Biology and Biotechnology of Saclay (iBiTec-S), LERMIT LabEx, Paris Saclay University, Gif sur Yvette, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Cintrat
authors.affiliation: CEA, Section of Molecular Engineering of Proteins (SIMOPRO), Institute of Biology and Biotechnology of Saclay (iBiTec-S), LERMIT LabEx, Paris Saclay University, Gif sur Yvette, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gillet
mesh_terms: D002695:Chlamydiales / Q000276:immunology / Q000502:physiology*; D006658:Histoplasma / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007891:Leishmania / Q000276:immunology / Q000502:physiology*; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology*