title: NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives.
abstract: Fourteen novel 4-aminoquinazoline derivatives 2-15 were designed and synthesized. The structure of the newly synthesized compounds was established on the basis of elemental analyses, IR, (1)H-NMR, (13)C-NMR, and mass spectral data. The compounds were evaluated for their potential cytoprotective activity in murine Hepa1c1c7 cells. All of the synthesized compounds showed concentration-dependent ability to induce the cytoprotective enzyme
  quinone oxidoreductase (NQO1) with potencies in the low- to sub-micromolar range. This approach offers an encouraging framework which may lead to the discovery of potent cytoprotective agents.
authors.affiliation: a Department of Pharmacognosy , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia .|b Department of Drug Radiation Research , National Center for Radiation Research and Technology, Atomic Energy Authority , Nasr City , Cairo , Egypt .
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Ghorab
authors.affiliation: a Department of Pharmacognosy , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia .
authors.forename: Mansour S
authors.initials: MS
authors.lastname: Alsaid
authors.affiliation: b Department of Drug Radiation Research , National Center for Radiation Research and Technology, Atomic Energy Authority , Nasr City , Cairo , Egypt .
authors.forename: Marwa G
authors.initials: MG
authors.lastname: El-Gazzar
authors.affiliation: c Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee , Dundee , UK .
authors.forename: Maureen
authors.initials: M
authors.lastname: Higgins
authors.affiliation: c Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee , Dundee , UK .|d Departments of Medicine and Pharmacology and Molecular Sciences , Johns Hopkins University School of Medicine , Baltimore , MD , USA , and.
authors.forename: Albena T
authors.initials: AT
authors.lastname: Dinkova-Kostova
authors.affiliation: a Department of Pharmacognosy , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia .|e Phytochemistry Department , National Research Center Dokki , Cairo , Egypt.
authors.forename: Abdelaaty A
authors.initials: AA
authors.lastname: Shahat
mesh_terms: D000818:Animals; D002460:Cell Line; D004790:Enzyme Induction / Q000187:drug effects*; D051379:Mice; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000096:biosynthesis*; D011799:Quinazolines / Q000494:pharmacology; D013057:Spectrum Analysis / Q000379:methods
chemical_list: C573775:4-aminoquinazoline; D011799:Quinazolines; D016660:NAD(P)H Dehydrogenase (Quinone); C491732:Nqo1 protein, mouse
keywords: 4-aminoquinazoline; NAD(P)H; cytoprotective; synthesis