title: PECULIARITIES OF PHARMACOTHERAPY IN ARTERIAL HYPERTENSION AND COMORBID PATHOLOGY.
abstract: In patients with arterial hypertension (AH) pharmacotherapy often remains ineffective because of comorbid pathology. Research of haemodynamic and metabolic processes in such patients allows prescribe effective antihypertensive medicines, improve life quality and prognosis.
  
  
  METHODS
  60 patients with AH, coronary artery disease and obesity were divided into three groups: 1st group was treated with lisinopril + atorvastatin + aspirin (regimen I); 2nd group was treated with lisinopril + atorvastatin + bisoprolol + aspirin (regimen II); 3rd group was treated with lisinopril + bisoprolol + indapamide + atorvastatin + aspirin (regimen III). Laser correlation spectrometry (LCS) was used to evaluate the homeostatic alterations.
  
  
  RESULTS
  All regimens were equally effective in normalization of systolic blood pressure and did not influence the ejection fraction. Only in the 3rd group was determined significant increase of glomerular filtration rate (92.73 ± 2.12 vs 79.62 ± 13.62 ml/min/1.73m2). The LCS test showed that these patients had high level of light scattering particles IV, which may be caused by activation of anabolic processes. In other groups, spectral alterations were not so expressive.
  
  
  CONCLUSIONS
  Prescription of antihypertensive therapy cause homeostatic and metabolic alterations, which may influence the efficacy of treatment.
authors.forename: Nataliia
authors.initials: N
authors.lastname: Tofan
authors.forename: Muza
authors.initials: M
authors.lastname: Marish
authors.forename: V
authors.initials: V
authors.lastname: Shtanko
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D000069059:Atorvastatin / Q000627:therapeutic use; D017298:Bisoprolol / Q000627:therapeutic use*; D015992:Body Mass Index; D015897:Comorbidity; D003327:Coronary Disease / Q000150:complications; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology; D007190:Indapamide / Q000627:therapeutic use*; D017706:Lisinopril / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D012307:Risk Factors; D013057:Spectrum Analysis / Q000379:methods; D016896:Treatment Outcome; D014455:Ukraine / Q000453:epidemiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000924:Anticholesteremic Agents; D000959:Antihypertensive Agents; D000069059:Atorvastatin; D017706:Lisinopril; D007190:Indapamide; D001241:Aspirin; D017298:Bisoprolol