title: Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior.
abstract: Central thalamic deep brain stimulation (CT-DBS) has been proposed as an experimental therapeutic approach to produce consistent sustained regulation of forebrain arousal for several neurological diseases. We investigated local field potentials (LFPs) induced by CT-DBS from the thalamic central lateral nuclei (CL) and the striatum as potential biomarkers for the enhancement of lever-pressing skill learning. LFPs were simultaneously recorded from multiple sites in the CL, ventral striatum (Vstr), and dorsal striatum (Dstr). LFP oscillation power and functional connectivity were assessed and compared between the CT-DBS and sham control groups. The theta and alpha LFP oscillations were significantly increased in the CL and striatum in the CT-DBS group. Furthermore, interhemispheric coherences between bilateral CL and striatum were increased in the theta band. Additionally, enhancement of c-Fos activity, dopamine D2 receptor (Drd2), and α4-nicotinic acetylcholine receptor (α4-nAChR) occurred after CT-DBS treatment in the striatum and hippocampus. CT-DBS strengthened thalamic-striatal functional connectivity, which demonstrates that the inter-regional connectivity enhancement might contribute to synaptic plasticity in the striatum. Altered dopaminergic and cholinergic receptors resulted in modulation of striatal synaptic plasticity's ability to regulate downstream signaling cascades for higher brain functions of lever-pressing skill learning.
authors.affiliation: Department and Institute of Physiology, School of Medicine, National Yang Ming UniversityTaipei, Taiwan; Brain Research Center, National Yang Ming UniversityTaipei, Taiwan.
authors.forename: Hui-Ching
authors.initials: HC
authors.lastname: Lin
authors.affiliation: Institute of Neuroscience, National Yang Ming University Taipei, Taiwan.
authors.forename: Han-Chi
authors.initials: HC
authors.lastname: Pan
authors.affiliation: Department of Neurology, Tzu Chi General Hospital, Tzu Chi UniversityHualien, Taiwan; Institute of Biomedical Engineering, National Taiwan UniversityTaipei, Taiwan.
authors.forename: Sheng-Huang
authors.initials: SH
authors.lastname: Lin
authors.affiliation: Institute of Medical Device and Imaging, National Taiwan University College of Medicine Taipei, Taiwan.
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Lo
authors.affiliation: Institute of Biomedical Engineering, National Taiwan University Taipei, Taiwan.
authors.forename: Elise Ting-Hsin
authors.initials: ET
authors.lastname: Shen
authors.affiliation: Centre for Life Sciences, Singapore Institute for Neurotechnology, National University of SingaporeSingapore, Singapore; Institute of Biomedical Engineering and Nanomedicine, National Health Research InstitutesMiaoli, Taiwan.
authors.forename: Lun-De
authors.initials: LD
authors.lastname: Liao
authors.affiliation: Department of Biomedical Engineering, National Yang Ming University Taipei, Taiwan.
authors.forename: Pei-Han
authors.initials: PH
authors.lastname: Liao
authors.affiliation: Department of Biomedical Engineering, National Yang Ming University Taipei, Taiwan.
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Chien
authors.affiliation: Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University Taipei, Taiwan.
authors.forename: Kuei-Da
authors.initials: KD
authors.lastname: Liao
authors.affiliation: Institute of Biomedical Engineering, National Taiwan University Taipei, Taiwan.
authors.forename: Fu-Shan
authors.initials: FS
authors.lastname: Jaw
authors.affiliation: Department and Institute of Physiology, School of Medicine, National Yang Ming University Taipei, Taiwan.
authors.forename: Kai-Wen
authors.initials: KW
authors.lastname: Chu
authors.affiliation: Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University Hangzhou, China.
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Lai
authors.affiliation: Department of Biomedical Engineering, National Yang Ming University Taipei, Taiwan.
authors.forename: You-Yin
authors.initials: YY
authors.lastname: Chen
mesh_terms: D000513:Alpha Rhythm / Q000502:physiology; D000818:Animals; D003071:Cognition / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology; D046690:Deep Brain Stimulation / Q000379:methods*; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000378:metabolism; D012201:Reward; D013788:Thalamus / Q000502:physiology*; D013826:Theta Rhythm / Q000502:physiology
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D017448:Receptors, Dopamine D2; D011978:Receptors, Nicotinic; C000607792:DRD2 protein, rat
keywords: deep brain stimulation; functional connectivity; local field potentials; reward-associated learning; thalamus