title: Electrospinning chitosan/poly(ethylene oxide) solutions with essential oils: Correlating solution rheology to nanofiber formation.
abstract: Electrospinning hydrophilic nanofiber mats that deliver hydrophobic agents would enable the development of new therapeutic wound dressings. However, the correlation between precursor solution properties and nanofiber morphology for polymer solutions electrospun with or without hydrophobic oils has not yet been demonstrated. Here, cinnamaldehyde (CIN) and hydrocinnamic alcohol (H-CIN) were electrospun in chitosan (CS)/poly(ethylene oxide) (PEO) nanofiber mats as a function of CS molecular weight and degree of acetylation (DA). Viscosity stress sweeps determined how the oils affected solution viscosity and chain entanglement (Ce) concentration. Experimentally, the maximum polymer:oil mass ratio electrospun was 1:3 and 1:6 for CS/PEO:CIN and:H-CIN, respectively; a higher chitosan DA increased the incorporation of H-CIN only. The correlations determined for electrospinning plant-derived oils could potentially be applied to other hydrophobic molecules, thus broadening the delivery of therapeutics from electrospun nanofiber mats.
authors.affiliation: Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003-9303, United States.
authors.forename: Katrina A
authors.initials: KA
authors.lastname: Rieger
authors.affiliation: Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003-9303, United States.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Birch
authors.affiliation: Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003-9303, United States. Electronic address: schiffman@ecs.umass.edu.
authors.forename: Jessica D
authors.initials: JD
authors.lastname: Schiffman
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008970:Molecular Weight; D057139:Nanofibers / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012212:Rheology; D012996:Solutions; D013678:Technology, Pharmaceutical; D014783:Viscosity
chemical_list: D000438:Alcohols; D009822:Oils, Volatile; D012996:Solutions; D011092:Polyethylene Glycols; D000171:Acrolein; D048271:Chitosan; C012843:cinnamaldehyde
keywords: Chitosan; Electrospin; Essential oil; Nanofiber; Oil-in-water; Rheology