title: Enantioselective cellular uptake of chiral semiconductor nanocrystals.
abstract: The influence of the chirality of semiconductor nanocrystals, CdSe/ZnS quantum dots (QDs) capped with L- and D-cysteine, on the efficiency of their uptake by living Ehrlich Ascite carcinoma cells is studied by spectral- and time-resolved fluorescence microspectroscopy. We report an evident enantioselective process where cellular uptake of the L-Cys QDs is almost twice as effective as that of the D-Cys QDs. This finding paves the way for the creation of novel approaches to control the biological properties and behavior of nanomaterials in living cells.
authors.affiliation: ITMO University, 49 Kronverksky pr., St. Petersburg, 197101, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Martynenko
authors.forename: V A
authors.initials: VA
authors.lastname: Kuznetsova
authors.forename: I K
authors.initials: IK
authors.lastname: Litvinov
authors.forename: A O
authors.initials: AO
authors.lastname: Orlova
authors.forename: V G
authors.initials: VG
authors.lastname: Maslov
authors.forename: A V
authors.initials: AV
authors.lastname: Fedorov
authors.forename: A
authors.initials: A
authors.lastname: Dubavik
authors.forename: F
authors.initials: F
authors.lastname: Purcell-Milton
authors.forename: Yu K
authors.initials: YK
authors.lastname: Gun'ko
authors.forename: A V
authors.initials: AV
authors.lastname: Baranov
mesh_terms: D000818:Animals; D001692:Biological Transport; D019187:Cadmium Compounds / Q000032:analysis / Q000378:metabolism*; D002460:Cell Line; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism*; D005453:Fluorescence; D051379:Mice; D061848:Optical Imaging; D045663:Quantum Dots / Q000032:analysis / Q000378:metabolism*; D018036:Selenium Compounds / Q000032:analysis / Q000378:metabolism*; D013237:Stereoisomerism; D013440:Sulfides / Q000032:analysis / Q000378:metabolism*; D017967:Zinc Compounds / Q000032:analysis / Q000378:metabolism*
chemical_list: D019187:Cadmium Compounds; D018036:Selenium Compounds; D013440:Sulfides; D017967:Zinc Compounds; C058667:cadmium selenide; D003545:Cysteine; C031238:zinc sulfide