title: Magnetic resonance imaging for prostate cancer: Comparative studies including radical prostatectomy specimens and template transperineal biopsy.
abstract: OBJECTIVE
  Multiparametric magnetic resonance imaging (mpMRI) is an emerging technique aiming to improve upon the diagnostic sensitivity of prostate biopsy. Because of variance in interpretation and application of techniques, results may vary. There is likely a learning curve to establish consistent reporting of mpMRI. This study aims to review current literature supporting the diagnostic utility of mpMRI when compared with radical prostatectomy (RP) and template transperineal biopsy (TTPB) specimens.
  
  
  METHODS
  MEDLINE and PubMed database searches were conducted identifying relevant literature related to comparison of mpMRI with RP or TTPB histology.
  
  
  RESULTS
  Data suggest that compared with RP and TTPB specimens, the sensitivity of mpMRI for prostate cancer (PCa) detection is 80-90% and the specificity for suspicious lesions is between 50% and 90%.
  
  
  CONCLUSIONS
  mpMRI has an increasing role for PCa diagnosis, staging, and directing management toward improving patient outcomes. Its sensitivity and specificity when compared with RP and TTPB specimens are less than what some expect, possibly reflecting a learning curve for the technique of mpMRI.
authors.affiliation: University of Melbourne, Department of Surgery, Urology Unit, Austin Health, Melbourne, Australia.
authors.forename: Liam
authors.initials: L
authors.lastname: Toner
authors.affiliation: University of Melbourne, Department of Surgery, Urology Unit, Austin Health, Melbourne, Australia.
authors.forename: Mahesha
authors.initials: M
authors.lastname: Weerakoon
authors.affiliation: University of Melbourne, Department of Surgery, Urology Unit, Austin Health, Melbourne, Australia; Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia.
authors.forename: Damien M
authors.initials: DM
authors.lastname: Bolton
authors.affiliation: Department of Pathology, TissuPath Specialist Pathology Services, Melbourne, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Ryan
authors.affiliation: University of Melbourne, Department of Surgery, Urology Unit, Austin Health, Melbourne, Australia.
authors.forename: Nikolas
authors.initials: N
authors.lastname: Katelaris
authors.affiliation: University of Melbourne, Department of Surgery, Urology Unit, Austin Health, Melbourne, Australia; Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia; Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
authors.forename: Nathan
authors.initials: N
authors.lastname: Lawrentschuk
keywords: Diagnosis; Histopathology; Magnetic resonance imaging; Prostate; Prostatectomy; Prostatic neoplasms