title: Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm.
abstract: In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population. Three hundred and eighty-one patients with abdominal aortic aneurysm and age- and gender-matched healthy controls (N = 381) were collected between March 2012 and March 2014. The IL-10 -1082G/A, -819T/C, and -592A/C polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Logistic regression analyses revealed that the AA genotype of IL-10 -1082G/A was associated with an increased risk of abdominal aortic aneurysm compared to the GG genotype in a codominant model [odds ratio (OR) = 1.64, 95% confidence interval (CI) = 1.04-2.60]. Moreover, the GA+AA genotype was correlated with an elevated risk of abdominal aortic aneurysm compared to the GG genotype in a dominant model (OR = 1.34, 95%CI = 1.01-1.79). In conclusion, the results of our study suggested that the A allele of IL-10 -1082G/A is significantly associated with the development of abdominal aortic aneurysm compared to the wide-type genotype.
authors.affiliation: Department of Vascular Interventional Surgery, Linyi People Hospital, Shandong University, Linyi, Shandong, China.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Vascular Interventional Surgery, Linyi People Hospital, Shandong University, Linyi, Shandong, China.
authors.forename: Q Q
authors.initials: QQ
authors.lastname: Quan
authors.affiliation: Department of Vascular Interventional Surgery, Linyi People Hospital, Shandong University, Linyi, Shandong, China.
authors.forename: C L
authors.initials: CL
authors.lastname: Zhang
authors.affiliation: Department of Vascular Interventional Surgery, Linyi People Hospital, Shandong University, Linyi, Shandong, China.
authors.forename: Y B
authors.initials: YB
authors.lastname: Li
authors.affiliation: Department of Vascular Interventional Surgery, Linyi People Hospital, Shandong University, Linyi, Shandong, China.
authors.forename: T B
authors.initials: TB
authors.lastname: Jiang
mesh_terms: D000328:Adult; D017544:Aortic Aneurysm, Abdominal / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D016753:Interleukin-10