title: Circadian Dexras1 in rats: Development, location and responsiveness to light.
abstract: Dexras1 has been shown to exhibit clock-dependent rhythm in mice suprachiasmatic nucleus (SCN), and its genetic deletion modulates circadian responses to photic and nonphotic cues. We show that the rhythmic expression of Dexras1 mRNA and protein in rat SCN already oscillates with low amplitude at postnatal day 3 and can be detected as early as embryonic day 20. In contrast, its expression in peripheral tissues is not rhythmic in adult rats either. The Dexras1 protein is expressed predominantly in the dorsomedial part of the SCN and the light pulse has only a limited effect on its expression. Our data provide the descriptive basis for speculation about the Dexras1 involvement in the rat circadian physiology.
authors.affiliation: a Faculty of Science , Charles University in Prague , Prague , Czech Republic.
authors.forename: Klára
authors.initials: K
authors.lastname: Hahnová
authors.affiliation: a Faculty of Science , Charles University in Prague , Prague , Czech Republic.
authors.forename: Dominika
authors.initials: D
authors.lastname: Pačesová
authors.affiliation: a Faculty of Science , Charles University in Prague , Prague , Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Volfová
authors.affiliation: a Faculty of Science , Charles University in Prague , Prague , Czech Republic.
authors.forename: Kateřina
authors.initials: K
authors.lastname: Červená
authors.affiliation: a Faculty of Science , Charles University in Prague , Prague , Czech Republic.
authors.forename: Dita
authors.initials: D
authors.lastname: Kašparová
authors.affiliation: a Faculty of Science , Charles University in Prague , Prague , Czech Republic.
authors.forename: Jitka
authors.initials: J
authors.lastname: Žurmanová
authors.affiliation: a Faculty of Science , Charles University in Prague , Prague , Czech Republic.
authors.forename: Zdeňka
authors.initials: Z
authors.lastname: Bendová
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D008027:Light; D008297:Male; D056950:Period Circadian Proteins / Q000378:metabolism; D010775:Photic Stimulation / Q000379:methods; D012333:RNA, Messenger / Q000378:metabolism; D017208:Rats, Wistar; D013493:Suprachiasmatic Nucleus / Q000502:physiology*; D018631:ras Proteins / Q000235:genetics*
chemical_list: D056950:Period Circadian Proteins; D012333:RNA, Messenger; C528215:Rasd1 protein, rat; D018631:ras Proteins
keywords: Dexras1; light; rat; suprachiasmatic nucleus