title: Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
abstract: The neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 µg) was intrathecally administered in rats with spinal cord ischemia. Propofol pre-treatment greatly improved rat pathological changes and neurological function deficits at 24 hours after spinal cord ischemia. These results suggest that intrathecal administration of propofol exhibits neuroprotective effects on spinal cord structural and functional damage caused by ischemia.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Amasya, Amasya, Turkey.
authors.forename: Murat
authors.identifier: 0000-0003-1180-2204
authors.initials: M
authors.lastname: Sahin
authors.affiliation: Department of Anesthesiology and Reanimation, Mengucek Gazi Research and Training Hospital, Erzincan, Turkey.
authors.forename: Huriye
authors.initials: H
authors.lastname: Gullu
authors.affiliation: Department of General Surgery, Faculty of Medicine, University of Erzincan, Erzincan, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Peker
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Erzincan, Erzincan, Turkey.
authors.forename: Ilyas
authors.initials: I
authors.lastname: Sayar
authors.affiliation: Department of Anesthesiology and Reanimation, Mengucek Gazi Research and Training Hospital, Erzincan, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Binici
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Sutcu Imam, Kahramanmaras, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Yildiz
keywords: ischemia; nerve regeneration; neural regeneration; neuroprotection; paraplegia; pre-treatment; propofol; spinal cord