title: Role of Donepezil in the Management of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia with Lewy Bodies.
abstract: Alzheimer's disease (AD) is a progressive condition that affects cognition, function, and behavior. Approximately 60-90% of patients with AD develop neuropsychiatric symptoms (NPS) such as hallucinations, delusions, agitation/aggression, dysphoria/depression, anxiety, irritability, disinhibition, euphoria, apathy, aberrant motor behavior, sleep disturbances, appetite and eating changes, or altered sexual behavior. These noncognitive behavior changes are thought to result from anatomical and biochemical changes within the brain, and have been linked, in part, to cholinergic deficiency. Cholinesterase inhibitors may reduce the emergence of NPS and have a role in their treatment. These agents may delay initiation of, or reduce the need for, other drugs such as antipsychotics. This article summarizes the effects of donepezil, a cholinesterase inhibitor, on the NPS of dementia with emphasis on AD and dementia with Lewy bodies.
authors.affiliation: Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Cummings
authors.affiliation: Department of Psychiatry, Chung Shan Medical University Hospital, Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Te-Jen
authors.initials: TJ
authors.lastname: Lai
authors.affiliation: Department of Psychiatry, King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Solaphat
authors.initials: S
authors.lastname: Hemrungrojn
authors.affiliation: Department of Psychological Medicine, Sun Medical and Research Centre, Thrissur, Kerala, India.
authors.forename: E
authors.initials: E
authors.lastname: Mohandas
authors.affiliation: Department of Neurology, Seoul National University College of Medicine & Seoul National University Bundang Hospital, Seoul, Korea.
authors.forename: Sang
authors.initials: S
authors.lastname: Yun Kim
authors.affiliation: Department of Neurology, Fortis Hospital Mahim, Mumbai, India.
authors.forename: Girish
authors.initials: G
authors.lastname: Nair
authors.affiliation: Eisai Co. Ltd., Mumbai, India.
authors.forename: Amitabh
authors.initials: A
authors.lastname: Dash
mesh_terms: D000544:Alzheimer Disease / Q000150:complications*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D000077265:Donepezil; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D020961:Lewy Body Disease / Q000150:complications*; D010880:Piperidines / Q000627:therapeutic use*; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil
keywords: Alzheimer disease; Behavioral symptoms; Cholinesterase inhibitors; Dementia; Donepezil