title: Serum Jo-1 Autoantibody and Isolated Arthritis in the Antisynthetase Syndrome: Review of the Literature and Report of the Experience of AENEAS Collaborative Group.
abstract: Anti-Jo-1 is the most frequently detectable antibody in the antisynthetase syndrome (ASSD), an autoimmune disease characterized by the occurrence of arthritis, myositis, and interstitial lung disease (ILD). Recently, we organized an international collaborative group called American and European NEtwork of Antisynthetase Syndrome (AENEAS) for the study of this rare and fascinating disease. The group collected and published one of the largest series of ASSD patients ever described and with one of the longer follow-up ever reported. The number of participating centers is steadily increasing, as well as the available cohort. In the first paper, we showed that arthritis, myositis, and ILD may be frequently the only feature at disease onset, raising problems to reach a correct diagnosis of this syndrome. Nevertheless, we first observed that the ex novo appearance of further manifestations is common during the follow-up, strengthening the importance of a correct diagnosis. In our cohort, the 24 % of the 243 patients up to now collected had isolated arthritis as a presenting feature. These patients represent the most intriguing group in terms of differential diagnosis and clinical time course. Furthermore, data on this aspect are scanty, the reason that lead us to evaluate these aspects in our cohort of patients, reviewing also available literature. In fact, the most relevant aspect is that ASSD is rarely suspected in this setting of patients, in particular in case of poliarticular involvement, positive rheumatoid factor (RF), or anti-cyclic citrullinated peptide antibodies (ACPA) or evidence of joint erosions at plain radiographs. These findings were not rare in our cohort, and they have been also described in other series. Furthermore, manifestations such as Raynaud's phenomenon, mechanic's hands, and fever that may lead to the suspect of ASSD are observed only in a third of cases. If we consider the high rate of clinical picture progression in these patients, we feel that ASSD should be carefully considered in all patients presenting with isolated arthritis, even in those with erosive, RF, and ACPA-positive arthritis.
authors.affiliation: Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy. cavagna@unipv.it.
authors.forename: Lorenzo
authors.identifier: http://orcid.org/0000-0003-3292-1528
authors.initials: L
authors.lastname: Cavagna
authors.affiliation: Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Nuño
authors.affiliation: Epidemiology Unit, Italian Society for Rheumatology, Milano, Italy.
authors.forename: Carlo Alberto
authors.initials: CA
authors.lastname: Scirè
authors.affiliation: UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Ferrara, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Govoni
authors.affiliation: Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Francisco Javier Lopez
authors.initials: FJ
authors.lastname: Longo
authors.affiliation: Rheumatology Unit, University and AO Spedali Civili, Brescia, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Franceschini
authors.affiliation: Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Neri
authors.affiliation: Rheumatology Department, Hospital Universitario de la Princesa, IIS Princesa, Madrid, Spain.
authors.forename: Santos
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authors.lastname: Castañeda
authors.affiliation: Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: Walter Alberto
authors.initials: WA
authors.lastname: Sifuentes Giraldo
authors.affiliation: Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Caporali
authors.affiliation: Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy.
authors.forename: Florenzo
authors.initials: F
authors.lastname: Iannone
authors.affiliation: Rheumatology Department, Città Della Salute e della Scienza, Torino, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Fusaro
authors.affiliation: Rheumatology Unit, Santa Chiara Hospital, Trento, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolazzi
authors.affiliation: Division of Rheumatology, Mauriziano Hospital, Turin, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Pellerito
authors.affiliation: Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schwarting
authors.affiliation: Tulane University Lung Center Tulane/UMC Scleroderma and Sarcoidosis Patient Care and Research Center New Orleans, New Orleans, LA, USA.
authors.forename: Lesley Ann
authors.initials: LA
authors.lastname: Saketkoo
authors.affiliation: Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain.
authors.forename: Norberto
authors.initials: N
authors.lastname: Ortego-Centeno
authors.affiliation: Clinic of Rheumatology, Department of Medical and Biological Sciences (DSMB), Santa Maria della Misericordia Hospital, Udine, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Quartuccio
authors.affiliation: Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Bartoloni
authors.affiliation: Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic, Essen, Germany.
authors.forename: Christof
authors.initials: C
authors.lastname: Specker
authors.affiliation: Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.
authors.forename: Trinitario
authors.initials: T
authors.lastname: Pina Murcia
authors.affiliation: UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Ferrara, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: La Corte
authors.affiliation: UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Ferrara, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Furini
authors.affiliation: UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Ferrara, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Foschi
authors.affiliation: Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Bachiller Corral
authors.affiliation: Rheumatology Unit, University and AO Spedali Civili, Brescia, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Airò
authors.affiliation: Rheumatology Unit, University and AO Spedali Civili, Brescia, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Cavazzana
authors.affiliation: Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Julia
authors.initials: J
authors.lastname: Martínez-Barrio
authors.affiliation: Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Michelle
authors.initials: M
authors.lastname: Hinojosa
authors.affiliation: Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Giannini
authors.affiliation: Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Barsotti
authors.affiliation: Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Menke
authors.affiliation: ACURA Rheumatology Center, Bad Kreuznach, Germany.
authors.forename: Kostantinos
authors.initials: K
authors.lastname: Triantafyllias
authors.affiliation: Division of Rheumatology, Mauriziano Hospital, Turin, Italy.
authors.forename: Rosetta
authors.initials: R
authors.lastname: Vitetta
authors.affiliation: Division of Rheumatology, Mauriziano Hospital, Turin, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Russo
authors.affiliation: Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Bogliolo
authors.affiliation: Rheumatology Unit, Department of Internal Medicine, S.Maria Hospital-IRCCS, Reggio Emilia, Italy.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Bajocchi
authors.affiliation: Rheumatology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Bravi
authors.affiliation: Rheumatology Unit, Santa Chiara Hospital, Trento, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barausse
authors.affiliation: Rheumatology Unit, Santa Chiara Hospital, Trento, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bortolotti
authors.affiliation: Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Milano, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Selmi
authors.affiliation: Rheumatology Department, Città Della Salute e della Scienza, Torino, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Parisi
authors.affiliation: Rheumatology Department, Polytechnic University of Marche, C. Urbani Hospital, Jesi, Ancona, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Salaffi
authors.affiliation: Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy.
authors.forename: Carlomaurizio
authors.initials: C
authors.lastname: Montecucco
authors.affiliation: Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: González-Gay
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood* / Q000276:immunology; D001168:Arthritis / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D006643:Histidine-tRNA Ligase / Q000276:immunology; D006801:Humans; D009220:Myositis / Q000097:blood / Q000150:complications / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; C046750:Jo-1 antibody; D006643:Histidine-tRNA Ligase
keywords: Anti-Jo-1; Anti-cyclic citrullinated peptide; Antisynthetase syndrome; Clinical time course; Isolated polyarthritis; Rheumatoid factor