title: Higher pericardial adiposity is associated with prevalent diabetes: The Coronary Artery Risk Development in Young Adults study.
abstract: OBJECTIVE
  Pericardial adipose tissue (PAT) is located on both sides of the pericardium. We tested whether PAT was associated with prevalent diabetes at the year 25 exam of the Coronary Artery Risk Development in Young Adults (CARDIA) study.
  
  
  RESULTS
  The CARDIA Year 25 exam (2010-2011) included complete data for all covariates on 3107 participants. Prevalent diabetes (n = 436) was defined as high fasting (≥126 mg/dl) or 2-h postload glucose (≥200 mg/dl) or HbA1c (≥6.5%) or use of diabetes medications. Volume of PAT was measured from computed tomographic scans. Logistic regression was performed to examine the relationship between quartiles of PAT and diabetes. In regression models adjusted for field center, sex, race, age, systolic blood pressure, total cholesterol, log triglycerides, and treatment with blood pressure and cholesterol lowering medication, PAT volume in the 4th quartile was significantly associated with diabetes status after adjustment for BMI (OR 2.57, 95% CI 1.66, 3.98) or visceral adipose tissue (OR 2.08, 95% CI 1.32, 3.29). PAT volume in the 2nd and 3rd quartiles was not significantly associated with diabetes status relative to the first quartile.
  
  
  CONCLUSIONS
  Metabolically active pericardial adipose tissue is associated with prevalent diabetes only at higher volumes independent of overall obesity.
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B Downs Blvd, MDC 56, Tampa, FL 33612-3805, USA. Electronic address: aalman@health.usf.edu.
authors.forename: A C
authors.initials: AC
authors.lastname: Alman
authors.affiliation: Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Jacobs
authors.affiliation: Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Lewis
authors.affiliation: Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Snell-Bergeon
authors.affiliation: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Carnethon
authors.affiliation: Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Terry
authors.affiliation: Colorado School of Public Health, Aurora, CO, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Goff
authors.affiliation: Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
authors.forename: J
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Carr
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D050154:Adiposity; D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000209:etiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D010496:Pericardium / Q000378:metabolism; D015995:Prevalence; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: Diabetes; Obesity; Pericardial adipose tissue; Visceral adipose tissue