title: [Association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins].
abstract: OBJECTIVE
  To investigate the association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins.
  
  
  METHODS
  A total of 147 pairs of twins (47 pairs of monozygotic twins, 100 pairs of dizygotic twins) aged 8-12 years from Baotou and Hohhot were selected as respondents. The Achenbach Child Behavior Checklist (CBCL) was used to calculate the scores of anxiety-depression factors in school-aged twins. The DNA was extracted from oral epithelial cells, and polymerase chain reaction was applied for 5-HTTLPR genotyping. The generalized estimating equation (GEE) was used to analyze the effect of 5-HTTLPR polymorphism and family environment on anxiety-depression in school-aged twins.
  
  
  RESULTS
  The children with LS and SS genotypes had significantly higher scores of anxiety-depression factors than those with LL genotype (χ2=3.938, P<0.05). The interaction of 5-HTTLPR genotype with family cohesion and family rearing patterns had a significant impact on the scores of anxiety-depression factors in twins (χ2=6.129 and 7.665, both P<0.05).
  
  
  CONCLUSIONS
  5-HTTLPR genotype is significantly correlated with the scores of anxiety-depression factors in school-aged twins. In the family with high cohesion and an autocratic family rearing pattern, S allele may increase the possibility of anxiety-depression in twin children.
authors.affiliation: Institute of Life Science and Technology, Inner Mongolia Normal University, Huhhot 010022, China. liyuling137@163.com.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Zhao
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Li
authors.lastname: Enherbayaer
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
mesh_terms: D001007:Anxiety / Q000235:genetics*; D002648:Child; D003863:Depression / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D014427:Twins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins