title: Analyzing Long-Duration and High-Frequency Data Using the Time-Varying Effect Model.
abstract: With the rapid development of methods for electronic data capture, longitudinal data sets with many assessment points have become common in mental health services and addiction research. These data typically exhibit complex and irregular patterns of change, and the relationship between variables may also change over time. Existing statistical methods are not flexible enough to capture this complexity, but a new method, the time-varying effect model (TVEM), permits modeling nearly any shape of change, and allows the effect of an independent variable on outcome to change over time. This paper introduces TVEM and illustrates its application using data from a 16-year study of 223 participants with serious mental illness and substance abuse.
authors.affiliation: Dartmouth Psychiatric Research Center, Department of Biomedical Data Science and Community and Family Medicine, Geisel School of Medicine at Dartmouth, Haiyi Xie, 46 Centerra Parkway, Suite 300, Lebanon, NH, 03766, USA. Haiyi.Xie@Dartmouth.Edu.
authors.forename: Haiyi
authors.initials: H
authors.lastname: Xie
authors.affiliation: Dartmouth Psychiatric Research Center, Department of Psychiatry and Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03766, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Drake
authors.affiliation: Dartmouth Psychiatric Research Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03766, USA.
authors.forename: Sunny Jung
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Dartmouth Psychiatric Research Center, Department of Psychiatry and Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03766, USA.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: McHugo
mesh_terms: D035843:Biomedical Research / Q000379:methods; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D001523:Mental Disorders / Q000628:therapy*; D008605:Mental Health Services / Q000458:organization & administration* / Q000706:statistics & numerical data*; D015233:Models, Statistical; D012107:Research Design; D016320:Substance Abuse Treatment Centers / Q000458:organization & administration* / Q000706:statistics & numerical data*; D019966:Substance-Related Disorders / Q000628:therapy*; D013997:Time Factors
keywords: Dynamic relationship; Intensive longitudinal data; Mental illness and substance abuse; Time-varying effect