title: A New Class of Phantom Materials for Poroelastography Imaging Techniques.
abstract: Poroelastography is an elastographic technique used to image the temporal mechanical behavior of tissues. One of the major challenges in determining experimental potentials and limitations of this technique has been the lack of complex and realistic controlled phantoms that could be used to corroborate the limited number of theoretical and simulation studies available in the literature as well as to predict its performance in complex experimental situations and in a variety of conditions. In the study described here, we propose and analyze a new class of phantom materials for temporal elastography imaging. The results indicate that, by using polyacrylamide, we can generate inhomogeneous elastographic phantoms with controlled fluid content and fluid flow properties, while maintaining mechanical and ultrasonic properties similar to those of soft tissues.
authors.affiliation: Department of Electrical and Computer Engineering, Texas A&M University, College Station, Texas, USA.
authors.forename: Anuj
authors.initials: A
authors.lastname: Chaudhry
authors.affiliation: Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas, USA; Department of Biomedical Engineering, University of Houston, Houston, Texas, USA.
authors.forename: Iman K
authors.initials: IK
authors.lastname: Yazdi
authors.affiliation: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.
authors.forename: Rohit
authors.initials: R
authors.lastname: Kongari
authors.affiliation: Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas, USA.
authors.forename: Ennio
authors.initials: E
authors.lastname: Tasciotti
authors.affiliation: Department of Electrical and Computer Engineering, Texas A&M University, College Station, Texas, USA. Electronic address: righetti@ece.tamu.edu.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Righetti
mesh_terms: D000180:Acrylic Resins / Q000032:analysis / Q000737:chemistry*; D040761:Biomimetic Materials / Q000032:analysis / Q000138:chemical synthesis*; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008422:Materials Testing; D019047:Phantoms, Imaging; D016062:Porosity; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000180:Acrylic Resins; C016680:polyacrylamide gels
keywords: Elastography; Imaging; Inhomogeneous phantoms; Permeability; Polyacrylamide gels; Poroelastography; Ultrasound