title: Palladium-Catalyzed Trifluoromethylation of (Hetero)Arenes with CF3 Br.
abstract: The CF3 group is an omnipresent motif found in many pharmaceuticals, agrochemicals, catalysts, materials, and industrial chemicals. Despite well-established trifluoromethylation methodologies, the straightforward and selective introduction of such groups into (hetero)arenes using available and less expensive sources is still a major challenge. In this regard, the selective synthesis of various trifluoromethyl-substituted (hetero)arenes by palladium-catalyzed C-H functionalization is herein reported. This novel methodology proceeds under comparably mild reaction conditions with good regio- and chemoselectivity. As examples, trifluoromethylations of biologically important molecules, such as melatonin, theophylline, caffeine, and pentoxifylline, are showcased.
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany.
authors.forename: Kishore
authors.initials: K
authors.lastname: Natte
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany.
authors.forename: Rajenahally V
authors.initials: RV
authors.lastname: Jagadeesh
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany.
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany.
authors.forename: Jabor
authors.initials: J
authors.lastname: Rabeah
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Lonza Ltd, Rottenstrasse 6, CH-3930, Visp, Switzerland.
authors.forename: Christoph
authors.initials: C
authors.lastname: Taeschler
authors.affiliation: Lonza Ltd, Rottenstrasse 6, CH-3930, Visp, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ellinger
authors.affiliation: Lonza Ltd, Rottenstrasse 6, CH-3930, Visp, Switzerland.
authors.forename: Florencio
authors.initials: F
authors.lastname: Zaragoza
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany.
authors.forename: Helfried
authors.initials: H
authors.lastname: Neumann
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany.
authors.forename: Angelika
authors.initials: A
authors.lastname: Brückner
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059, Rostock, Germany. matthias.beller@catalysis.de.
authors.forename: Matthias
authors.identifier: http://orcid.org/0000-0001-5709-0965
authors.initials: M
authors.lastname: Beller
keywords: C−H activation; arenes; fluorine; palladium; radical chemistry