title: The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol.
abstract: Resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs.
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, Slovakia. kotora@fns.uniba.sk.
authors.forename: Peter
authors.initials: P
authors.lastname: Kotora
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, Slovakia. f.sersen@gmail.com.
authors.forename: František
authors.initials: F
authors.lastname: Šeršeň
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, Slovakia. filo@fns.uniba.sk.
authors.forename: Juraj
authors.initials: J
authors.lastname: Filo
authors.affiliation: Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, Slovakia. dusan.looos@chello.sk.
authors.forename: Dušan
authors.initials: D
authors.lastname: Loos
authors.affiliation: Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, Slovakia. juraj.gregan@univie.ac.at.|Department of Chromosome Biology, MFPL, University of Vienna, Dr. Bohr-Gasse 9, 1030 Vienna, Austria. juraj.gregan@univie.ac.at.
authors.forename: Juraj
authors.initials: J
authors.lastname: Gregáň
authors.affiliation: Department of Chemistry, Faculty of Natural Sciences, Matej Bell University, Tajovského 40, 974 01 Banská Bystrica, Slovakia. Fridrich.Gregan@umb.sk.
authors.forename: Fridrich
authors.initials: F
authors.lastname: Gregáň
mesh_terms: D001559:Benzhydryl Compounds / Q000037:antagonists & inhibitors*; D052160:Benzothiazoles / Q000037:antagonists & inhibitors*; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors*; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D010851:Picrates / Q000037:antagonists & inhibitors*; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*; D013451:Sulfonic Acids / Q000037:antagonists & inhibitors*
chemical_list: D001559:Benzhydryl Compounds; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D013267:Stilbenes; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D000077185:Resveratrol; C020338:galvinoxyl
keywords: antioxidant activity; iminophenols; resveratrol analogs