title: Bioactive Diterpenoids from Clerodendrum kiangsiense.
abstract: A new abeo-abietane diterpenoid, 12-methoxy-6,11,14,16-tetrahydroxy-17(15→16)-abeo-5,8,11,13-abietatetraen-3,7-dione (8), was isolated from the hydroalcoholic extract of the herb of Clerodendrum kiangsiense along with seven known diterpenoids (1-7). Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HL-60, SMMC-7721, A-549 and MCF-7 by the MTT assay. The results showed that cryptojaponol (4), fortunin E (6) and 8 exhibited significant cytotoxicity against four human cancer cell lines.
authors.affiliation: Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou 310036, China. zjxmf@163.com.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Xu
authors.affiliation: Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou 310036, China. shinya33@163.com.
authors.forename: Shengjia
authors.initials: S
authors.lastname: Wang
authors.affiliation: Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou 310036, China. prospectjoy@sina.com.
authors.forename: Ouya
authors.initials: O
authors.lastname: Jia
authors.affiliation: Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou 310036, China. zhuqin@hznu.edu.cn.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou 310036, China. shilue@126.com.
authors.forename: Lu'e
authors.initials: L
authors.lastname: Shi
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D032409:Clerodendrum / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D018547:Plant Stems / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes
keywords: Clerodendrum kiangsiense; abeo-abietane diterpenoid; cytotoxicity