title: Transitional Meningioma After Fetal Liver-Derived Cell Suspension Allotransplant: A Case Report.
abstract: Diabetes mellitus is a disease with no definite cure. In recent years, stem cell transplant has led to treatment of various diseases including diabetes. We sought to report a type 1 diabetic patient with a brain mass, diagnosed as transitional meningioma, after a fetal hematopoietic stem cell transplant. A 57-year-old woman with type 1 diabetes who previously had undergone a fetal hematopoietic stem cell transplant, attended the clinic with a history of progressive bifrontal headaches accompanied by nausea, vomiting, and visual disturbances over the previous 8 months. Investigations revealed a 2-cm mass in the right temporal region. The patient underwent a craniotomy, and the lesion was removed and sent for pathological and genetic investigations. The results indicated transitional meningioma with the origin of transplanted fetal hematopoietic stem cells. To our knowledge, this is the first report of transitional meningioma as a result of stem cell transplant. Despite all unanswered questions about the safety of stem cell transplant, this novel therapy provides hope for patients with type 1 diabetes.
authors.affiliation: >From the Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute; and the 2Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ensieh
authors.initials: E
authors.lastname: Nasli-Esfahani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghadami
authors.forename: Peyvand
authors.initials: P
authors.lastname: Amini
authors.forename: Somayeh
authors.initials: S
authors.lastname: Amiri
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghodsi
authors.forename: Camelia
authors.initials: C
authors.lastname: Rambod
authors.forename: Ali
authors.initials: A
authors.lastname: Tootee
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
mesh_terms: D003399:Craniotomy; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D053686:Fetal Stem Cells / Q000473:pathology / Q000637:transplantation*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008579:Meningioma / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D016896:Treatment Outcome; D047368:Tumor Burden