title: Pharmacological opportunities to control inflammatory diseases through inhibition of the leukocyte recruitment.
abstract: Leukocyte recruitment to tissues is a highly orchestrated process and is one of the pillars of the inflammatory process. The contribution of leukocytes to tissue damage is very clear, suggesting that targeting leukocyte accumulation in tissue to be relevant for the development of novel therapies to treat chronic inflammatory diseases. Here, we review briefly known mechanisms of leukocyte recruitment and suggest potential targets for the development of novel anti-inflammatory therapies.
authors.affiliation: Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
authors.forename: Raphael S
authors.initials: RS
authors.lastname: Peres
authors.affiliation: Department of Morphology, University Federal of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Gustavo B
authors.initials: GB
authors.lastname: Menezes
authors.affiliation: Department of Biochemistry and Immunology, University Federal of Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: mmtex.ufmg@gmail.com.
authors.forename: Mauro M
authors.initials: MM
authors.lastname: Teixeira
authors.affiliation: Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address: fdqcunha@fmrp.usp.br.
authors.forename: Fernando Q
authors.initials: FQ
authors.lastname: Cunha
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002908:Chronic Disease / Q000188:drug therapy; D055808:Drug Discovery; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D036904:Leukocyte Rolling / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects* / Q000502:physiology; D058990:Molecular Targeted Therapy; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors; D019087:Selectins / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D019707:Receptors, Chemokine; D019087:Selectins
keywords: Chronic inflammatory diseases; Drug discovery; Inflammation; Leukocyte recruitment; Therapies