title: Prostate Cancer and Li-Fraumeni Syndrome: Implications for Screening and Therapy.
abstract: Li-Fraumeni Syndrome (LFS) is an autosomal dominant genetic disorder associated with mutations in the TP53 gene and characterized by a propensity to develop a variety of malignancies resulting in a shortened lifespan. We report a case of prostate cancer in a 50 year old male with LFS. Experimental studies suggest that TP53 mutations in prostate cancer are associated with therapeutic resistance to radiation, chemotherapy, and anti-androgens, implying that LFS men may experience more aggressive cancer biology with implications for therapeutic decisions. The potential of prostate cancer to develop earlier in LFS favors institution of screening at earlier ages.
authors.affiliation: Medical Dietetics and Health Sciences, School of Health and Rehabilitation Sciences, College of Medicine, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Colleen K
authors.initials: CK
authors.lastname: Spees
authors.affiliation: College of Public Health, The Ohio State University, Columbus, OH, USA; Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Kelleher
authors.affiliation: Department of Urology, The Ohio State University College of Medicine, Columbus, OH, USA; Robotic Urologic Surgery, OhioHealth Dublin Methodist Hospital, Dublin, OH, USA.
authors.forename: Ronney
authors.initials: R
authors.lastname: Abaza
authors.affiliation: Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Urology, The Ohio State University College of Medicine, Columbus, OH, USA; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Clinton
keywords: Li-Fraumeni Syndrome; Prostate cancer; TP53; p53