title: Genetic determination of height-mediated mate choice.
abstract: BACKGROUND
  Numerous studies have reported positive correlations among couples for height. This suggests that humans find individuals of similar height attractive. However, the answer to whether the choice of a mate with a similar phenotype is genetically or environmentally determined has been elusive.
  
  
  RESULTS
  Here we provide an estimate of the genetic contribution to height choice in mates in 13,068 genotyped couples. Using a mixed linear model we show that 4.1% of the variation in the mate height choice is determined by a person's own genotype, as expected in a model where one's height determines the choice of mate height. Furthermore, the genotype of an individual predicts their partners' height in an independent dataset of 15,437 individuals with 13% accuracy, which is 64% of the theoretical maximum achievable with a heritability of 0.041. Theoretical predictions suggest that approximately 5% of the heritability of height is due to the positive covariance between allelic effects at different loci, which is caused by assortative mating. Hence, the coupling of alleles with similar effects could substantially contribute to the missing heritability of height.
  
  
  CONCLUSIONS
  These estimates provide new insight into the mechanisms that govern mate choice in humans and warrant the search for the genetic causes of choice of mate height. They have important methodological implications and contribute to the missing heritability debate.
authors.affiliation: The Roslin Institute, The University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, Scotland, UK. Albert.Tenesa@ed.ac.uk.|MRC HGU at the MRC IGMM, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, Scotland, UK. Albert.Tenesa@ed.ac.uk.|Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, Scotland, UK. Albert.Tenesa@ed.ac.uk.
authors.forename: Albert
authors.initials: A
authors.lastname: Tenesa
authors.affiliation: The Roslin Institute, The University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, Scotland, UK.|Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, Scotland, UK.
authors.forename: Konrad
authors.initials: K
authors.lastname: Rawlik
authors.affiliation: MRC HGU at the MRC IGMM, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, Scotland, UK.
authors.forename: Pau
authors.initials: P
authors.lastname: Navarro
authors.affiliation: The Roslin Institute, The University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, Scotland, UK.|Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, Scotland, UK.
authors.forename: Oriol
authors.initials: O
authors.lastname: Canela-Xandri
mesh_terms: D000483:Alleles; D001827:Body Height; D005260:Female; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008297:Male; D010641:Phenotype; D012725:Sexual Behavior