title: Physical Activity, Sedentary Time, and Sleep and the Association With Inflammatory Markers and Adiponectin in 8- to 11-Year-Old Danish Children.
abstract: Inflammatory markers, adiponectin, and movement/nonmovement behaviors have all been linked to risk factors for cardiovascular disease; however, the association between childhood movement/nonmovement behaviors and inflammatory markers and adiponectin is unknown.
  
  
  
  We explored the association between accelerometer determined moderate-to-vigorous physical activity (MVPA), sedentary time, and sleep (7 days/8 nights) and fasting C-reactive protein (CRP), interleukin-6 (IL-6), and adiponectin in 806 school children. A sleep variability score was calculated.
  
  
  
  MVPA was negatively associated with adiponectin in boys and girls (P < .001) and with CRP and IL-6 in girls (P < .05) independent of sleep duration, sedentary time, age, fat mass index (FMI), and pubertal status. Sedentary time was positively associated with adiponectin in boys and girls (both P < .001), and sleep duration with adiponectin in boys independent of age, FMI, and pubertal status (P < .001); however, these associations disappeared after mutual adjustments for movement behavior. Sleep duration variability was positively associated with CRP in girls independent of all covariates (P < .01).
  
  
  
  MVPA remained negatively associated with inflammatory markers and adiponectin, and sleep duration variability positively associated with CRP after adjustment for FMI, pubertal status, and other movement behavior. The inverse association between MVPA and adiponectin conflicts with the anti-inflammatory properties of adiponectin.
authors.affiliation: Dept of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Mette S
authors.initials: MS
authors.lastname: Nielsen
authors.forename: Jonas S
authors.initials: JS
authors.lastname: Quist
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Chaput
authors.forename: Stine-Mathilde
authors.initials: SM
authors.lastname: Dalskov
authors.forename: Camilla T
authors.initials: CT
authors.lastname: Damsgaard
authors.forename: Christian
authors.initials: C
authors.lastname: Ritz
authors.forename: Arne
authors.initials: A
authors.lastname: Astrup
authors.forename: Kim F
authors.initials: KF
authors.lastname: Michaelsen
authors.forename: Anders
authors.initials: A
authors.lastname: Sjödin
authors.forename: Mads F
authors.initials: MF
authors.lastname: Hjorth
mesh_terms: D061725:Accelerometry; D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D016000:Cluster Analysis; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D012307:Risk Factors; D012890:Sleep / Q000502:physiology*; D013548:Sweden
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein