title: Use of high-dose prednisolone to overcome rifampicin-induced corticosteroid non-responsiveness in childhood nephrotic syndrome.
abstract: Inducing remission in nephrotic children on anti-tubercular therapy is difficult due to the increased metabolism of prednisolone induced by rifampicin. We report a child with nephrotic syndrome treated successfully with an increased dose of steroids without discontinuing anti-tubercular therapy.
authors.affiliation: Department of Pediatric Disciplines, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India.
authors.forename: H
authors.initials: H
authors.lastname: Barman
authors.forename: R
authors.initials: R
authors.lastname: Dass
authors.forename: S G
authors.initials: SG
authors.lastname: Duwarah
mesh_terms: D002648:Child; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D019384:Nucleic Acid Synthesis Inhibitors / Q000009:adverse effects; D011239:Prednisolone / Q000008:administration & dosage*; D012293:Rifampin / Q000009:adverse effects*
chemical_list: D005938:Glucocorticoids; D019384:Nucleic Acid Synthesis Inhibitors; D011239:Prednisolone; D012293:Rifampin