title: Evolution of endovascular stroke therapies and devices.
abstract: Acute ischemic stroke is caused by occlusion of a cerebral artery, resulting in loss of brain tissue and neurologic deficits. However, a portion of the ischemic brain can be salvaged if blood flow is restored within an appropriate time frame. The past year has seen the publication of five positive randomized controlled trials demonstrating substantial benefit of mechanical thrombectomy in select patients with large vessel cerebrovascular occlusion. This progress is related to several factors, but most importantly, dramatic improvements in speed and rates of recanalization with the latest generation devices. In this article, we review the evolution of endovascular acute ischemic stroke therapies and key design features of the most widely used devices.
authors.affiliation: a Mallinckrodt Institute of Radiology , Washington University School of Medicine , Saint Louis , MO , USA.
authors.forename: Adam N
authors.initials: AN
authors.lastname: Wallace
authors.affiliation: a Mallinckrodt Institute of Radiology , Washington University School of Medicine , Saint Louis , MO , USA.
authors.forename: Akash P
authors.initials: AP
authors.lastname: Kansagra
authors.affiliation: a Mallinckrodt Institute of Radiology , Washington University School of Medicine , Saint Louis , MO , USA.
authors.forename: James
authors.initials: J
authors.lastname: McEachern
authors.affiliation: a Mallinckrodt Institute of Radiology , Washington University School of Medicine , Saint Louis , MO , USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Moran
authors.affiliation: a Mallinckrodt Institute of Radiology , Washington University School of Medicine , Saint Louis , MO , USA.
authors.forename: Dewitte T
authors.initials: DT
authors.lastname: Cross
authors.affiliation: b Department of Radiology , University of Iowa Hospitals and Clinics , Iowa City , IA , USA.
authors.forename: Colin P
authors.initials: CP
authors.lastname: Derdeyn
mesh_terms: D000818:Animals; D057510:Endovascular Procedures / Q000295:instrumentation*; D006801:Humans; D015607:Stents; D020521:Stroke / Q000628:therapy*; D013396:Suction; D017131:Thrombectomy; D015912:Thrombolytic Therapy
keywords: Stroke; catheter; endovascular; stentriever; technique; thrombectomy