title: [What future for circulating tumor DNA? Current data and prospects in colorectal, non-small cell lung and pancreatic cancers].
abstract: Ten years after the discovery of the predictive value of KRAS status for anti-EGFR antibodies, other genes involved in oncogenesis and therapeutic responses were identified and are now systematically sought. Molecular diagnosis often requires invasive procedures, sometimes iatrogenic, and is limited by feasibility problems, quantity and quality of samples. Identifying these mutations from blood biomarkers would reduce costs and diagnostic delay. The circulating tumor DNA (ctDNA) is one of the most promising blood biomarkers. In this review, we report and discuss the latest results obtained with ctDNA in colorectal cancer, non-small cell lung cancer, and adenocarcinoma of the pancreas. If the methods highlighting appear very heterogeneous, the correlation between mutations found in tumor and those identified in the blood exceeds 95 % specificity in numerous studies. The detection sensitivity is in turn strongly related to tumor stage patients. The presence of ctDNA appears as a prognostic factor for progression-free survival and overall survival. Finally, recent studies have shown that the changing rate ctDNA during systemic treatments had a predictive value for therapeutic efficacy. These results allow to consider the use of ctDNA in monitoring patients to identify early recurrence or progression.
authors.affiliation: Université Paris Sorbonne Cité, centre universitaire des Saints-Pères, CNRS SNC5014, Inserm UMR-S1147 MEPPOT, 75006 Paris, France; Assistance publique-Hôpitaux de Paris, groupe hospitalier Pitié-Salpêtrière, service de chirurgie digestive et hépato-biliaire, 75013 Paris, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pietrasz
authors.affiliation: Université Paris Sorbonne Cité, centre universitaire des Saints-Pères, CNRS SNC5014, Inserm UMR-S1147 MEPPOT, 75006 Paris, France; Assistance publique-Hôpitaux de Paris, hôpital européen Georges-Pompidou, service d'oncologie médicale, 75015 Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pécuchet
authors.affiliation: Université Paris Sorbonne Cité, centre universitaire des Saints-Pères, CNRS SNC5014, Inserm UMR-S1147 MEPPOT, 75006 Paris, France; Assistance publique-Hôpitaux de Paris, hôpital européen Georges-Pompidou, service d'oncologie médicale, 75015 Paris, France.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fabre
authors.affiliation: Université Paris Sorbonne Cité, centre universitaire des Saints-Pères, CNRS SNC5014, Inserm UMR-S1147 MEPPOT, 75006 Paris, France; Assistance publique-Hôpitaux de Paris, hôpital européen Georges-Pompidou, pôle de biologie, 75015 Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Blons
authors.affiliation: Assistance publique-Hôpitaux de Paris, groupe hospitalier Pitié-Salpêtrière, pôle 3I, service d'hépatogastroentérologie, 75013 Paris, France.
authors.forename: Line
authors.initials: L
authors.lastname: Chevalier
authors.affiliation: Université Paris Sorbonne Cité, centre universitaire des Saints-Pères, CNRS SNC5014, Inserm UMR-S1147 MEPPOT, 75006 Paris, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Taly
authors.affiliation: Université Paris Sorbonne Cité, centre universitaire des Saints-Pères, CNRS SNC5014, Inserm UMR-S1147 MEPPOT, 75006 Paris, France; Assistance publique-Hôpitaux de Paris, hôpital européen Georges-Pompidou, pôle de biologie, 75015 Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Laurent-Puig
authors.affiliation: Université Paris Sorbonne Cité, centre universitaire des Saints-Pères, CNRS SNC5014, Inserm UMR-S1147 MEPPOT, 75006 Paris, France; Assistance publique-Hôpitaux de Paris, groupe hospitalier Pitié-Salpêtrière, pôle 3I, service d'hépatogastroentérologie, 75013 Paris, France; Université Sorbonne, université Pierre-et-Marie-Curie, Paris 06, 75005 Paris, France. Electronic address: jean-baptiste.bachet@aphp.fr.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Bachet
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D015179:Colorectal Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D004273:DNA, Neoplasm / Q000097:blood*; D018572:Disease-Free Survival; D005819:Genetic Markers; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D012680:Sensitivity and Specificity
chemical_list: D004273:DNA, Neoplasm; D005819:Genetic Markers
keywords: ADN tumoral circulant; Cancer colorectal; Cancer du pancréas; Cancer pulmonaire non à petites cellules; Circulating tumor DNA; Colorectal cancer; Non-small cell lung cancer; Pancreatic cancer