title: Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure.
abstract: Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.
authors.affiliation: Center for Rare Diseases, Department of Pediatrics, Catholic University, Rome, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Leoni
authors.affiliation: Center for Rare Diseases, Department of Pediatrics, Catholic University, Rome, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Onesimo
authors.affiliation: Department of Pediatrics, Catholic University, Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Giorgio
authors.affiliation: Artificial Nutrition Unit, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Diamanti
authors.affiliation: Center for Rare Diseases, Department of Pediatrics, Catholic University, Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Giorgio
authors.affiliation: Center for Rare Diseases, Department of Pediatrics, Catholic University, Rome, Italy.
authors.forename: Lucilla
authors.initials: L
authors.lastname: Martini
authors.affiliation: Center for Rare Diseases, Department of Pediatrics, Catholic University, Rome, Italy.
authors.forename: Aurora
authors.initials: A
authors.lastname: Rossodivita
authors.affiliation: Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Tartaglia
authors.affiliation: Center for Rare Diseases, Department of Pediatrics, Catholic University, Rome, Italy. Electronic address: alipino@alice.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zampino
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D056685:Costello Syndrome / Q000150:complications* / Q000378:metabolism; D004734:Energy Metabolism; D005183:Failure to Thrive / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D000090063:Proto-Oncogene Mas; D012146:Rest / Q000502:physiology*; D055815:Young Adult