title: A Serendipitous Synthesis of 11a-Hydroxy-11,11a-dihydrobenzo[e]indeno[2,1-b][1,4]diazepine-10,12-dione Derivatives by Condensation of 2-Aminobenzamides with Ninhydrin in Water.
abstract: Ninhydrin undergoes an unprecedented condensation reaction with various 2-aminobenzamide derivatives in boiling water to afford 11a-hydroxy-11,11a-dihydrobenzo[e]indeno[2,1-b][1,4]diazepine-10,12-dione derivatives. These hitherto unreported products are easily isolated in high yield by a simple filtration step. An interesting "ortho effect" was observed in the condensation reaction of ninhydrin with 2-amino-N-phenylbenzamide derivatives having an ortho- substituent in the N-phenyl moiety wherein the corresponding expected 3'-phenyl-1'H-spiro[indene-2,2'-quinazoline]-1,3,4'(3'H)-triones were obtained.
authors.affiliation: Department of Dyestuff Technology, Institute of Chemical Technology (formerly UDCT) , N. P. Marg, Matunga, Mumbai 400 019, Maharashtra, India.
authors.forename: Rajkumari Vijilata
authors.initials: RV
authors.lastname: Devi
authors.affiliation: Department of Dyestuff Technology, Institute of Chemical Technology (formerly UDCT) , N. P. Marg, Matunga, Mumbai 400 019, Maharashtra, India.
authors.forename: Ashok M
authors.initials: AM
authors.lastname: Garande
authors.affiliation: Human Resource Development Division, Bhabha Atomic Research Centre , Mumbai 400085, India.|Homi Bhabha National Institute, Training School Complex , Anushaktinagar, Mumbai 400094, India.
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Maity
authors.affiliation: Department of Dyestuff Technology, Institute of Chemical Technology (formerly UDCT) , N. P. Marg, Matunga, Mumbai 400 019, Maharashtra, India.
authors.forename: Prakash M
authors.initials: PM
authors.lastname: Bhate