title: Dynamic Transmission Economic Evaluation of Infectious Disease Interventions in Low- and Middle-Income Countries: A Systematic Literature Review.
abstract: Economic evaluation using dynamic transmission models is important for capturing the indirect effects of infectious disease interventions. We examine the use of these methods in low- and middle-income countries, where infectious diseases constitute a major burden. This review is comprised of two parts: (1) a summary of dynamic transmission economic evaluations across all disease areas published between 2011 and mid-2014 and (2) an in-depth review of mosquito-borne disease studies focusing on health economic methods and reporting. Studies were identified through a systematic search of the MEDLINE database and supplemented by reference list screening. Fifty-seven studies were eligible for inclusion in the all-disease review. The most common subject disease was HIV/AIDS, followed by malaria. A diverse range of modelling methods, outcome metrics and sensitivity analyses were used, indicating little standardisation. Seventeen studies were included in the mosquito-borne disease review. With notable exceptions, most studies did not employ economic evaluation methods beyond calculating a cost-effectiveness ratio or net benefit. Many did not adhere to health care economic evaluations reporting guidelines, particularly with respect to full model reporting and uncertainty analysis. We present a summary of the state-of-the-art and offer recommendations for improved implementation and reporting of health economic methods in this crossover discipline.
authors.affiliation: University of Oxford, Oxford, UK.|Mahidol University, Bangkok, Thailand.
authors.forename: Tom L
authors.initials: TL
authors.lastname: Drake
authors.affiliation: University of Oxford, Oxford, UK.|Mahidol University, Bangkok, Thailand.
authors.forename: Angela
authors.initials: A
authors.lastname: Devine
authors.affiliation: London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Shunmay
authors.initials: S
authors.lastname: Yeung
authors.affiliation: University of Oxford, Oxford, UK.|Mahidol University, Bangkok, Thailand.
authors.forename: Nicholas P J
authors.initials: NP
authors.lastname: Day
authors.affiliation: University of Oxford, Oxford, UK.|Mahidol University, Bangkok, Thailand.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: White
authors.affiliation: University of Oxford, Oxford, UK.|Mahidol University, Bangkok, Thailand.
authors.forename: Yoel
authors.initials: Y
authors.lastname: Lubell
mesh_terms: D003141:Communicable Diseases / Q000191:economics / Q000635:transmission*; D003362:Cost-Benefit Analysis / Q000379:methods*; D003906:Developing Countries / Q000191:economics; D004470:Economics, Medical; D017048:Health Care Costs; D006302:Health Services Research; D006801:Humans
keywords: dynamic transmission modelling; economic evaluation; infectious disease; low income