title: Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model.
abstract: In patients with schizophrenia, γ-band (30-70 Hz) auditory steady-state electroencephalogram responses (ASSR) are reduced in power and phase locking. Here, we examined whether γ-ASSR deficits are also present in a mouse model of schizophrenia, whose behavioural changes have shown schizophrenia-like endophenotypes.
  
  
  
  Electroencephalogram in frontal cortex and local field potential in primary auditory cortex were recorded in phospholipase C β1 (PLC-β1) null mice during auditory binaural click trains at different rates (20-50 Hz), and compared with wild-type littermates.
  
  
  
  In mutant mice, the ASSR power was reduced at all tested rates. The phase locking in frontal cortex was reduced in the β band (20 Hz) but not in the γ band, whereas the phase locking in auditory cortex was reduced in the γ band. The cortico-cortical connectivity between frontal and auditory cortex was significantly reduced in mutant mice.
  
  
  
  The tested mouse model of schizophrenia showed impaired electrophysiological responses to auditory steady state stimulation, suggesting that it could be useful for preclinical studies of schizophrenia".
authors.affiliation: a Biomedical Engineering , Old Dominion University Norfolk , VA 23529 , USA ;
authors.forename: Yalda
authors.initials: Y
authors.lastname: Shahriari
authors.affiliation: a Biomedical Engineering , Old Dominion University Norfolk , VA 23529 , USA ;
authors.forename: Dean
authors.initials: D
authors.lastname: Krusienski
authors.affiliation: b Center for Neuroscience , Korea Institute of Science and Technology , Seoul , South Korea ;|c Department of Neuroscience , University of Science and Technology , Daejon , South Korea ;
authors.forename: Yamini Sureka
authors.initials: YS
authors.lastname: Dadi
authors.affiliation: b Center for Neuroscience , Korea Institute of Science and Technology , Seoul , South Korea ;|c Department of Neuroscience , University of Science and Technology , Daejon , South Korea ;
authors.forename: Misun
authors.initials: M
authors.lastname: Seo
authors.affiliation: d Center for Cognition and Sociality , Institute for Basic Sciences , Daejon , South Korea.
authors.forename: Hee-Sup
authors.initials: HS
authors.lastname: Shin
authors.affiliation: b Center for Neuroscience , Korea Institute of Science and Technology , Seoul , South Korea ;|c Department of Neuroscience , University of Science and Technology , Daejon , South Korea ;
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001303:Auditory Cortex / Q000503:physiopathology*; D004195:Disease Models, Animal; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012559:Schizophrenia / Q000503:physiopathology*
keywords: EEG; Schizophrenia; auditory-steady-state-response; mouse; oscillations