title: Volvalerine A, an unprecedented N-containing sesquiterpenoid dimer derivative from Valeriana officinalis var. latifolia.
abstract: Volvalerine A (1), a novel N-containing bisesquiterpenoid derivative with a dihydroisoxazole ring, and its possible biosynthetic precursor, 1-hydroxy-1,11,11-trimethyldecahydrocyclopropane azulene-10-one (2), were isolated from the roots of Valeriana officinalis var. latifolia. Their structures and relative configurations were identified using spectroscopic data and X-ray crystallography. A plausible biosynthetic pathway for 1 is also presented.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Xin-Hui
authors.initials: XH
authors.lastname: Ran
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
authors.affiliation: Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, People's Republic of China.
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: hujiangmiao@mail.kib.ac.cn.
authors.forename: Jiang-Miao
authors.initials: JM
authors.lastname: Hu
authors.affiliation: Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, People's Republic of China. Electronic address: zhaoyx1011@163.com.
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D007555:Isoxazoles / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D014632:Valerian / Q000737:chemistry*
chemical_list: D007555:Isoxazoles; D012717:Sesquiterpenes; D014315:Triterpenes; D000110:Acetylcholinesterase
keywords: Bisesquiterpenoid; Sesquiterpenoid; Valeriana officinalis var. latifolia; Valerianacae