title: MarginProbe© reduces the rate of re-excision following breast conserving surgery for breast cancer.
abstract: A positive margin status after breast conserving surgery (BCS) is one of the strongest predictors for local recurrence of intraductal (DCIS) and invasive carcinoma. As much as 20-50 % of patients with BCS need to undergo a second operation to receive free margins. In this study we tested the clinical performance of MarginProbe© (Dune Medical Devices, Paoli, PA, USA), a device for the intraoperative evaluation of surgical margins.
  
  
  
  A prospective clinical study was performed: The device was utilized in BCS of 150 patients treated at a single facility from November 2012 to June 2013. The re-excision rate was compared to the re-excision rate of a historical group of 172 patients treated with BCS at the same hospital without the application of the device. We analyzed whether the results of MarginProbe© are affected by the morphology, grading, size of the tumor, breast density, age, BMI or the use of marker-wires.
  
  
  
  The application of MarginProbe© resulted in an overall decreased re-excision rate of 14.6 %. In the subgroup of DCIS the re-excision rate was reduced from 61.7 to 23.1 %. In the subgroup of invasive lobular carcinomas the re-excision rate decreased from 37.0 to 19.0 %. MarginProbe© results were not affected by grading, tumor size, breast density, age, BMI or marker-wire application.
  
  
  
  MarginProbe© detects positive margins in invasive carcinoma, DCIS as well as in invasive lobular carcinoma. The device decreases the re-excision rate after BCS significantly. It does not interfere with any of the factors we examined.
authors.affiliation: Breast Center, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.|Department of Gynecology and Breast Center, Sankt-Gertrauden Hospital, Paretzer Str. 12, 10713, Berlin, Germany.
authors.forename: Jens-Uwe
authors.initials: JU
authors.lastname: Blohmer
authors.affiliation: Department of Gynecology and Breast Center, Sankt-Gertrauden Hospital, Paretzer Str. 12, 10713, Berlin, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Tanko
authors.affiliation: Breast Center, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
authors.forename: Janina
authors.initials: J
authors.lastname: Kueper
authors.affiliation: Breast Center, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.|Department of Gynecology and Breast Center, Sankt-Gertrauden Hospital, Paretzer Str. 12, 10713, Berlin, Germany.
authors.forename: Jessica
authors.initials: J
authors.lastname: Groß
authors.affiliation: Breast Center, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.|Department of Gynecology and Breast Center, Sankt-Gertrauden Hospital, Paretzer Str. 12, 10713, Berlin, Germany.
authors.forename: Ragna
authors.initials: R
authors.lastname: Völker
authors.affiliation: Breast Center, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany. anna.machleidt@charite.de.|Department of Gynecology and Breast Center, Sankt-Gertrauden Hospital, Paretzer Str. 12, 10713, Berlin, Germany. anna.machleidt@charite.de.
authors.forename: Anna
authors.initials: A
authors.lastname: Machleidt
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery; D018275:Carcinoma, Lobular / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000295:instrumentation*; D015412:Mastectomy, Segmental / Q000295:instrumentation*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control*; D018365:Neoplasm, Residual / Q000517:prevention & control; D011446:Prospective Studies; D012086:Reoperation / Q000706:statistics & numerical data*; D016896:Treatment Outcome
keywords: Breast conserving therapy; Free-margins breast cancer; MarginProbe©; Re-excision rate breast cancer