title: Recurrent Hepatocellular Carcinoma in Patient with Crohn's Disease: Incidental or Expected Outcome of Azathioprine?
abstract: Hepatocellular carcinoma (HCC) usually occurs in patients with underlying risk factors such as liver cirrhosis and chronic hepatitis B. Although patients with Crohn's disease (CD) are at an increased risk to develop malignancies such as colon cancer, the incidence of HCC in this population is extremely rare. We report a case of 62-year-old male with long history of CD treated with azathioprine (AZA) and aminosalicylic acid (ASA) who was incidentally diagnosed with HCC, for which left hepatectomy was done. Four years later during routine follow-up, patient had another hepatic lesion and underwent resection of the mass. The mechanism of occurrence of HCC in patient with CD is still controversial and may include immune mediated changes and medication related complications. AZA was reported in all case reports of CD that developed HCC. Through this report we hope to explore the complex pathophysiological mechanisms contributing to the development of HCC in the Crohn's disease patient population.
authors.affiliation: Department of Internal Medicine, St. Joseph's Regional Medical Center, New York Medical College, Paterson, NJ 07503, USA.
authors.forename: Youssef
authors.initials: Y
authors.lastname: Botros
authors.affiliation: Department of Internal Medicine, St. Joseph's Regional Medical Center, New York Medical College, Paterson, NJ 07503, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Mathews
authors.affiliation: Department of Gastroenterology, St. Joseph's Regional Medical Center, New York Medical College, Paterson, NJ 07503, USA.
authors.forename: Hiren
authors.initials: H
authors.lastname: Patel
authors.affiliation: Department of Gastroenterology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.
authors.forename: Nihar
authors.initials: N
authors.lastname: Shah
authors.affiliation: Department of Gastroenterology, St. Joseph's Regional Medical Center, New York Medical College, Paterson, NJ 07503, USA.
authors.forename: Walid
authors.initials: W
authors.lastname: Baddoura
authors.affiliation: Department of General and Hepatobiliary Surgery, St. Joseph's Regional Medical Center, Paterson, NJ 07503, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: de la Torre