title: The conserved molecular machinery in DNA mismatch repair enzyme structures.
abstract: The machinery of DNA mismatch repair enzymes is highly conserved in evolution. The process is initiated by recognition of a DNA mismatch, and validated by ATP and the presence of a processivity clamp or a methylation mark. Several events in MMR promote conformational changes that lead to progression of the repair process. Here we discuss functional conformational changes in the MMR proteins and we compare the enzymes to paralogs in other systems.
authors.affiliation: Division of Biochemistry and CGC.nl, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
authors.forename: Flora S
authors.initials: FS
authors.lastname: Groothuizen
authors.affiliation: Division of Biochemistry and CGC.nl, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: t.sixma@nki.nl.
authors.forename: Titia K
authors.initials: TK
authors.lastname: Sixma
mesh_terms: D000818:Animals; D017124:Conserved Sequence; D053843:DNA Mismatch Repair; D045643:DNA Repair Enzymes / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular
chemical_list: D045643:DNA Repair Enzymes
keywords: MutH; MutL; MutS; Structure conservation