title: Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats.
abstract: There are reports of positive effects of quercetin on cardiovascular pathologies, however, mainly due to its low biovailability, the mechanism remains elusive. Here, we report that one metabolite formed by human microflora (3-(3-hydroxyphenyl)propionic acid)relaxed isolated rat aorta and decreased arterial blood pressure in rats.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic.
authors.forename: Iveta
authors.initials: I
authors.lastname: Najmanová
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Pourová
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic.
authors.forename: Marie
authors.initials: M
authors.lastname: Vopršalová
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic.
authors.forename: Veronika
authors.initials: V
authors.lastname: Pilařová
authors.affiliation: Department of Biological and Medical Science, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Semecký
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Nováková
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic.
authors.forename: Přemysl
authors.initials: P
authors.lastname: Mladěnka
mesh_terms: D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000494:pharmacology*; D000069196:Gastrointestinal Microbiome; D006439:Hemodynamics; D006801:Humans; D066298:In Vitro Techniques; D016014:Linear Models; D008297:Male; D010636:Phenols / Q000494:pharmacology*; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D053719:Tandem Mass Spectrometry
chemical_list: C491266:3-hydroxyphenylpropionic acid; D005419:Flavonoids; D010636:Phenols; D011422:Propionates
keywords: Blood pressure; Flavonoid; Metabolite; Phenolic; Quercetin; Rat; Vascular