title: Pediatric B-Cell Lymphoma With Lymphoblastic Morphology, TdT Expression, MYC Rearrangement, and Features Overlapping With Burkitt Lymphoma.
abstract: Burkitt lymphoma (BL) and B-lymphoblastic lymphoma are subtypes of pediatric non-Hodgkin lymphoma with different presenting features, treatment, and outcomes. This case report documents a 5-year-old female who presented with B-cell lymphoma with lymphoblastic morphology, terminal deoxynucleotidyl transferase expression, MYC rearrangement, and features overlapping with BL. Genomic microarray analysis identified a gain on the long arm of chromosome 1 without other definitive changes. She was treated according to a BL protocol and remains in remission 16-months after initial diagnosis.
authors.affiliation: Division of Hematology-Oncology, Department of Pediatrics, School of Medicine and Primary Children's Hospital, University of Utah, Salt Lake City, Utah.
authors.forename: Jessica
authors.initials: J
authors.lastname: Meznarich
authors.affiliation: Department of Pathology, University of Utah and ARUP Laboratories, Salt Lake City, Utah.
authors.forename: Rodney
authors.initials: R
authors.lastname: Miles
authors.affiliation: ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah.
authors.forename: Christian N
authors.initials: CN
authors.lastname: Paxton
authors.affiliation: Division of Hematology-Oncology, Department of Pediatrics, School of Medicine and Primary Children's Hospital, University of Utah, Salt Lake City, Utah.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Afify
mesh_terms: D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics* / Q000378:metabolism; D004253:DNA Nucleotidylexotransferase / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism
chemical_list: C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D004253:DNA Nucleotidylexotransferase
keywords: B-lymphoblastic lymphoma; Burkitt lymphoma; MYC rearrangement