title: Clinicopathological characteristics of infiltrating lobular breast carcinoma in elderly women: Preliminary results.
abstract: This study was conducted to investigate the clinicopathological parameters in elderly women (aged >70 years) with infiltrating lobular carcinoma (ILC) of the breast and compare the results with those obtained from younger patients (aged 55-70 years). The study sample included a total of 46 women with ILCs, 10 aged >70 and 36 aged 55-70 years. The parameters analysed were tumor size, histological grade (HG), axillary lymph node involvement, distant metastasis and immunohistochemical expression of estrogen, progesterone and androgen receptors, Ki67, p53 and B cell lymphoma 2. Compared to women aged 55-70 years, ILCs in women aged >70 years were commonly of larger size (P=0.068) and were more frequently HG3 (P=0.024). There were no statistically significant differences in the other parameters analysed. Furthermore, we were unable to determine differences in cancer recurrence and mortality in the two patient subgroups during our follow-up. In conclusion, our preliminary results, based on the limited number of cases included in this study, indicate that i) ILCs in women aged >70 years tended to be larger compared to those in women aged 55-70 years and were more frequently of grade 3; and ii) there were no significant differences in terms of recurrence and mortality between the two patient subgroups during our follow-up.
authors.affiliation: Department of Radiology and Physical Medicine, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galicia 15706, Spain; Department of Nuclear Medicine, University Hospital of Santiago de Compostela, Santiago de Compostela, 15706 Galicia, Spain; Molecular Imaging Group, IDIS, Santiago de Compostela, 15706 Galicia, Spain; Tejerina Foundation, Madrid 28003 Galicia, Spain.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Ruibal
authors.affiliation: Department of Radiology and Physical Medicine, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galicia 15706, Spain; Department of Nuclear Medicine, University Hospital of Santiago de Compostela, Santiago de Compostela, 15706 Galicia, Spain; Molecular Imaging Group, IDIS, Santiago de Compostela, 15706 Galicia, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Aguiar
authors.affiliation: Clinical Laboratory, Hospital Arquitecto Marcide/Novoa Santos, Ferrol, 15405 Galicia, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Del Camen Del Río
authors.affiliation: Department of Pathology, Central University Hospital of Asturias, Oviedo, 33006 Asturias, Spain.
authors.forename: Primitiva
authors.initials: P
authors.lastname: Menéndez
authors.affiliation: Department of Surgery, Hospital Monte Naranco, Oviedo, 33012 Asturias, Spain.
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: Arias
authors.affiliation: Department of Nuclear Medicine, University Hospital of Santiago de Compostela, Santiago de Compostela, 15706 Galicia, Spain; Molecular Imaging Group, IDIS, Santiago de Compostela, 15706 Galicia, Spain.
authors.forename: Michel
authors.initials: M
authors.lastname: Herranz
keywords: >70 years; clinicopathological characteristics; elderly; infiltrating lobular carcinoma of the breast