title: [Cesarean Section Under Combined Spinal and Epidural Anesthesia for a Pregnant Woman with Primary Biliary Cirrhosis].
abstract: We report the successful anesthetic management of a pregnant woman with primary biliary cirrhosis (PBC) and autoimmune hepatitis who underwent cesarean section. A 35 year-old pregnant woman with PBC was diagnosed with preterm rupture of membranes (PROM). Emergent cesarean section was scheduled. AST and ALT were elevated and she complained of itching due to PBC. Hydrocortisone 50 mg was intravenously administered. Spinal anesthesia was initiated with 2.4 ml of 0.5% bupivacaine hydrochloride and 10 µg fentanyl at L3-4; sensory loss (T2) was confirmed. Morphine was not included in spinal anesthesia to avoid worsening of the itching. Epidural anesthesia at T12-L1 was performed for postoperative pain control. Surgery proceeded uneventfully and postoperative pain control was satisfactory. Combined spinal and epidural anesthesia was beneficial for the perioperative management of a pregnant woman with PBC and autoimmune hepatitis.
authors.forename: Akira
authors.initials: A
authors.lastname: Hyoda
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Komasawa
authors.forename: Sayuri
authors.initials: S
authors.lastname: Matsunami
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Minami
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D002045:Bupivacaine / Q000008:administration & dosage; D002585:Cesarean Section; D004338:Drug Combinations; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D008105:Liver Cirrhosis, Biliary / Q000150:complications*; D009020:Morphine / Q000008:administration & dosage; D011247:Pregnancy; D011248:Pregnancy Complications
chemical_list: D004338:Drug Combinations; D009020:Morphine; D005283:Fentanyl; D002045:Bupivacaine