title: Modelling the immune system response to epithelial wound infections.
abstract: In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.
authors.affiliation: Delft Institute of Applied Mathematics, Faculty of Civil Engineering, Delft University of Technology, Mekelweg 4, 2628 CD Delft, the Netherlands. Electronic address: F.J.Vermolen@tudelft.nl.
authors.forename: F J
authors.initials: FJ
authors.lastname: Vermolen
authors.affiliation: Delft Institute of Applied Mathematics, Faculty of Civil Engineering, Delft University of Technology, Mekelweg 4, 2628 CD Delft, the Netherlands. Electronic address: ECMMArkesteijn@gmail.com.
authors.forename: E C M M
authors.initials: EC
authors.lastname: Arkesteijn
authors.affiliation: Department of Biomedical Engineering, Tel Aviv University, 69978 Tel Aviv, Israel. Electronic address: gefen@eng.tau.ac.il.
authors.forename: A
authors.initials: A
authors.lastname: Gefen
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004848:Epithelium / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007962:Leukocytes / Q000473:pathology; D018448:Models, Immunological; D009716:Numerical Analysis, Computer-Assisted; D014945:Wound Healing; D014946:Wound Infection / Q000276:immunology* / Q000382:microbiology*
keywords: Cell-based modelling; Fundamental solutions; Immune system response