title: Clinical and MRI outcome of an osteochondral scaffold plug for the treatment of cartilage lesions in the knee.
abstract: Conflicting clinical outcomes have been reported recently with the use of an osteochondral scaffold plugs for cartilage repair in the knee. In this study, twenty patients were consecutively treated for their cartilage lesions with the synthetic plug technique. These patients were prospectively clinically evaluated with a mean follow-up of 34.15 months. Magnetic resonance imaging (MRI) was used for morphologic analysis of the cartilage repair. The patients included in this study showed a significant gradual clinical improvement after the osteochondral scaffold plug. However, this clinical improvement was not confirmed by the MRI findings of this cohort study. Subchondral bone changes were seen in all patients on MRI and deficient filling of the defect was noticed in in 30.7% of the cases at 24 months of follow-up. There was no evidence found to support osteoconductive bone ingrowth. Therefore, the use of this type of osteochondral scaffold plug in osteochondral repair is questionable. Level of evidence: IV.
authors.forename: Aad
authors.initials: A
authors.lastname: Dhollander
authors.forename: Peter
authors.initials: P
authors.lastname: Verdonk
authors.forename: Karl Fredrik
authors.initials: KF
authors.lastname: Almqvist
authors.forename: Rene
authors.initials: R
authors.lastname: Verdonk
authors.forename: Jan
authors.initials: J
authors.lastname: Victor
mesh_terms: D000293:Adolescent; D000328:Adult; D002357:Cartilage Diseases / Q000175:diagnosis* / Q000601:surgery; D002358:Cartilage, Articular / Q000473:pathology* / Q000601:surgery; D019902:Chondrocytes / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000379:methods; D011446:Prospective Studies; D054457:Tissue Scaffolds; D055815:Young Adult