title: Severe Vitamin D Deficiency Is Not Associated with Liver Damage in Morbidly Obese Patients.
abstract: A deficiency in vitamin D could be deleterious during chronic liver diseases. However, contradictory data have been published in patients with non-alcoholic fatty liver disease. The aim of the study was to compare the blood level of 25 hydroxy vitamin D (25-OH vitamin D) with the severity of liver lesions, in a large cohort of morbidly obese patients.
  
  
  
  Three hundred ninety-eight morbidly obese patients had a liver biopsy. The non-alcoholic steatohepatitis (NASH) Clinical Research Network Scoring System Definition and Scores were used. 25-OH vitamin D was evaluated with a Diasorin®Elisa Kit. Logistic regression analyses were performed to obtain predictive factors of the severity of liver histology.
  
  
  
  20.6 % of patients had NASH. The stage of fibrosis was F0 12.9 %, F1 57.36 %, F2 25.32 %, F3 (bridging fibrosis) 3.88 %, and F4 (cirrhosis) 0.52 %. The 25-OH vitamin D level inversely correlated to the NAS (r = 0.12 and p = 0.01) and to steatosis (r = 0.14 and p = 0.007); however, it was not associated with the presence of NASH. The level of vitamin D was significantly lower in patients with significant fibrosis compared to those without (15.9 (11.1-23.5) vs 19.6 (13.7-24.7) ng/ml, p = 0.02). There was an inverse correlation between the severity of fibrosis and the values of 25-OH vitamin D (r = 0.12 and p = 0.01). In a logistic regression analysis, no parameters were independently associated with the severity of fibrosis except the presence of steatohepatitis (1.94 (1.13-3.35) p = 0.017).
  
  
  
  Low levels of 25-OH vitamin D were not independently associated with liver damage in morbidly obese patients with non-alcoholic fatty liver diseases (NAFLD).
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France. rodolphe.anty@laposte.net.|Pôle Référence Hépatite C, Hôpital de l'Archet 2, Centre Hospitalier Universitaire of Nice, 151, Route Saint-Antoine de Ginestière, BP 3079, F-06202, Nice, Cedex 3, France. rodolphe.anty@laposte.net.|Faculty of Medecine, University of Nice-Sophia-Antipolis, Nice, F-06107, Cedex 2, France. rodolphe.anty@laposte.net.
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Anty
authors.affiliation: Pôle Référence Hépatite C, Hôpital de l'Archet 2, Centre Hospitalier Universitaire of Nice, 151, Route Saint-Antoine de Ginestière, BP 3079, F-06202, Nice, Cedex 3, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Hastier
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France.|Pôle Référence Hépatite C, Hôpital de l'Archet 2, Centre Hospitalier Universitaire of Nice, 151, Route Saint-Antoine de Ginestière, BP 3079, F-06202, Nice, Cedex 3, France.|Faculty of Medecine, University of Nice-Sophia-Antipolis, Nice, F-06107, Cedex 2, France.
authors.forename: Clémence M
authors.initials: CM
authors.lastname: Canivet
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France.|Faculty of Medecine, University of Nice-Sophia-Antipolis, Nice, F-06107, Cedex 2, France.|Biological Centre, Centre Hospitalier Universitaire of Nice, Nice, F-06107, Cedex 2, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Patouraux
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France.|Pôle Référence Hépatite C, Hôpital de l'Archet 2, Centre Hospitalier Universitaire of Nice, 151, Route Saint-Antoine de Ginestière, BP 3079, F-06202, Nice, Cedex 3, France.|Faculty of Medecine, University of Nice-Sophia-Antipolis, Nice, F-06107, Cedex 2, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Schneck
authors.affiliation: Biological Centre, Centre Hospitalier Universitaire of Nice, Nice, F-06107, Cedex 2, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ferrari-Panaia
authors.affiliation: Pôle Référence Hépatite C, Hôpital de l'Archet 2, Centre Hospitalier Universitaire of Nice, 151, Route Saint-Antoine de Ginestière, BP 3079, F-06202, Nice, Cedex 3, France.
authors.forename: Imed
authors.initials: I
authors.lastname: Ben-Amor
authors.affiliation: Biological Centre, Centre Hospitalier Universitaire of Nice, Nice, F-06107, Cedex 2, France.
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Saint-Paul
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France.|Pôle Référence Hépatite C, Hôpital de l'Archet 2, Centre Hospitalier Universitaire of Nice, 151, Route Saint-Antoine de Ginestière, BP 3079, F-06202, Nice, Cedex 3, France.|Faculty of Medecine, University of Nice-Sophia-Antipolis, Nice, F-06107, Cedex 2, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Gugenheim
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France.|Faculty of Medecine, University of Nice-Sophia-Antipolis, Nice, F-06107, Cedex 2, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gual
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France.|Pôle Référence Hépatite C, Hôpital de l'Archet 2, Centre Hospitalier Universitaire of Nice, 151, Route Saint-Antoine de Ginestière, BP 3079, F-06202, Nice, Cedex 3, France.|Faculty of Medecine, University of Nice-Sophia-Antipolis, Nice, F-06107, Cedex 2, France.
authors.forename: Antonio
authors.initials: A
authors.lastname: Iannelli
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France.|Pôle Référence Hépatite C, Hôpital de l'Archet 2, Centre Hospitalier Universitaire of Nice, 151, Route Saint-Antoine de Ginestière, BP 3079, F-06202, Nice, Cedex 3, France.|Faculty of Medecine, University of Nice-Sophia-Antipolis, Nice, F-06107, Cedex 2, France.
authors.forename: Albert
authors.initials: A
authors.lastname: Tran
mesh_terms: D000328:Adult; D001706:Biopsy; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000473:pathology; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D011446:Prospective Studies; D012720:Severity of Illness Index; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25 hydroxy vitamin D; Fibrosis; Morbidly obesity; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis