title: The Information Technology Infrastructure for the Translational Genomics Core and the Partners Biobank at Partners Personalized Medicine.
abstract: The Biobank and Translational Genomics core at Partners Personalized Medicine requires robust software and hardware. This Information Technology (IT) infrastructure enables the storage and transfer of large amounts of data, drives efficiencies in the laboratory, maintains data integrity from the time of consent to the time that genomic data is distributed for research, and enables the management of complex genetic data. Here, we describe the functional components of the research IT infrastructure at Partners Personalized Medicine and how they integrate with existing clinical and research systems, review some of the ways in which this IT infrastructure maintains data integrity and security, and discuss some of the challenges inherent to building and maintaining such infrastructure.
authors.affiliation: Partners HealthCare, 65 Landsdowne Street, Cambridge, MA 02155, USA. nboutin@partners.org.
authors.forename: Natalie
authors.initials: N
authors.lastname: Boutin
authors.affiliation: Partners HealthCare, 65 Landsdowne Street, Cambridge, MA 02155, USA. aholzbach@partners.org.
authors.forename: Ana
authors.initials: A
authors.lastname: Holzbach
authors.affiliation: Partners HealthCare, 65 Landsdowne Street, Cambridge, MA 02155, USA. lmahanta@partners.org.
authors.forename: Lisa
authors.initials: L
authors.lastname: Mahanta
authors.affiliation: Partners HealthCare, 65 Landsdowne Street, Cambridge, MA 02155, USA. jAldama@partners.org.
authors.forename: Jackie
authors.initials: J
authors.lastname: Aldama
authors.affiliation: Partners HealthCare, 65 Landsdowne Street, Cambridge, MA 02155, USA. xCerretani@partners.org.
authors.forename: Xander
authors.initials: X
authors.lastname: Cerretani
authors.affiliation: Partners HealthCare, 65 Landsdowne Street, Cambridge, MA 02155, USA. kembree1@partners.org.
authors.forename: Kevin
authors.initials: K
authors.lastname: Embree
authors.affiliation: Partners HealthCare, 65 Landsdowne Street, Cambridge, MA 02155, USA. iLeon@partners.org.
authors.forename: Irene
authors.initials: I
authors.lastname: Leon
authors.affiliation: Partners HealthCare, 65 Landsdowne Street, Cambridge, MA 02155, USA. nRathi@partners.org.
authors.forename: Neeta
authors.initials: N
authors.lastname: Rathi
authors.affiliation: Partners HealthCare, 65 Landsdowne Street, Cambridge, MA 02155, USA. mvickers@partners.org.
authors.forename: Matilde
authors.initials: M
authors.lastname: Vickers
keywords: biobank IT; biobank information technology; biobank software; personalized medicine IT; precision medicine IT