title: High-Resolution Laser Doppler Measurements of Microcirculation in the Deep Brain Structures: A Method for Potential Vessel Tracking.
abstract: BACKGROUND
  Laser Doppler flowmetry (LDF) can be used to measure cerebral microcirculation in relation to stereotactic deep brain stimulation (DBS) implantations.
  
  
  OBJECTIVE
  To investigate the microcirculation and total light intensity (TLI) corresponding to tissue grayness in DBS target regions with high-resolution LDF recordings, and to define a resolution which enables detection of small vessels.
  
  
  METHODS
  Stereotactic LDF measurements were made prior to DBS implantation with 0.5-mm steps in the vicinity to 4 deep brain targets (STN, GPi, Vim, Zi) along 20 trajectories. The Mann-Whitney U test was used to compare the microcirculation and TLI between targets, and the measurement resolution (0.5 vs. 1 mm). The numbers of high blood flow spots along the trajectories were calculated.
  
  
  RESULTS
  There was a significant difference (p < 0.05) in microcirculation between the targets. High blood flow spots were present at 15 out of 510 positions, 7 along Vim and GPi trajectories, respectively. There was no statistical difference between resolutions even though both local blood flow and TLI peaks could appear at 0.5-mm steps.
  
  
  CONCLUSIONS
  LDF can be used for online tracking of critical regions presenting blood flow and TLI peaks, possibly relating to vessel structures and thin laminas along stereotactic trajectories.
authors.affiliation: Department of Biomedical Engineering, Linkx00F6;ping University, Linkx00F6;ping, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Wårdell
authors.forename: Simone
authors.initials: S
authors.lastname: Hemm-Ode
authors.forename: Peter
authors.initials: P
authors.lastname: Rejmstad
authors.forename: Peter
authors.initials: P
authors.lastname: Zsigmond
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D046690:Deep Brain Stimulation; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged