title: Successful Treatment With Bosentan for Digital Ulcers Related to Mixed Cryoglobulinemia: A Case Report.
abstract: A 49-year-old man diagnosed with genotype 1 hepatitis C, CD5-positive marginal zone lymphoma, and mixed cryoglobulinemia type II developed skin ulcers and necrosis in his right foot. He was treated with amlodipine, corticosteroids, plasmapheresis, alprostadil, rituximab, and cyclophosphamide without a satisfactory response. For this reason, he required a partial amputation of the second, third, and fifth fingers of the right foot. To prevent ulcer deterioration of the first finger, bosentan was initiated. After 10 months of treatment, the ulcer completely healed and no adverse effects were experienced by the patient.
authors.affiliation: Departments of 1Pharmacy and 2Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: de Lorenzo-Pinto
authors.forename: Blanca
authors.initials: B
authors.lastname: Pinilla Llorente
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000527:Alprostadil / Q000627:therapeutic use; D017311:Amlodipine / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use; D000077300:Bosentan; D003449:Cryoglobulinemia / Q000150:complications / Q000628:therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D016523:Foot Ulcer / Q000188:drug therapy* / Q000209:etiology; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D000069283:Rituximab / Q000008:administration & dosage; D013449:Sulfonamides / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000959:Antihypertensive Agents; D000998:Antiviral Agents; D013449:Sulfonamides; D014665:Vasodilator Agents; D017311:Amlodipine; D000069283:Rituximab; D003520:Cyclophosphamide; D000527:Alprostadil; D000077300:Bosentan