title: Protective effect of α-lipoic acid against radiation-induced fibrosis in mice.
abstract: Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that α-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of α-LA. α-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and inhibited the up-regulation of TGF-β1-mediated p300/CBP activity. Thus, α-LA prevents radiation-induced fibrosis (RIF) by inhibiting the transcriptional activity of NF-κB through inhibition of histone acetyltransferase activity. α-LA is a new therapeutic methods that can be used in the prevention-treatment of RIF.
authors.affiliation: Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Seung-Hee
authors.initials: SH
authors.lastname: Ryu
authors.affiliation: Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Park
authors.affiliation: Department of Biomedical Sciences and Department of Pharmacology, Cell Dysfunction Research Center (CDRC), University of Ulsan College of Medicine, Seoul, Korea.|Cell Dysfunction Research Center and Bio-Medical Institute of Technology (BMIT), University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Sungmin
authors.initials: S
authors.lastname: Kwak
authors.affiliation: Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Heo
authors.affiliation: Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
authors.forename: Je-Won
authors.initials: JW
authors.lastname: Ryu
authors.affiliation: Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Biomedical Sciences and Department of Pharmacology, Cell Dysfunction Research Center (CDRC), University of Ulsan College of Medicine, Seoul, Korea.|Cell Dysfunction Research Center and Bio-Medical Institute of Technology (BMIT), University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Kyung-Chul
authors.initials: KC
authors.lastname: Choi
authors.affiliation: Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Lee
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005355:Fibrosis / Q000209:etiology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D011832:Radiation Injuries / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D008063:Thioctic Acid / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D011837:Radiation-Protective Agents; D008063:Thioctic Acid
keywords: NF-κB; PAI-1; acetylation; radiation-induced fibrosis; α-lipoic acid