title: The spectrum of onset of acute kidney injury in premature infants less than 30 weeks gestation.
abstract: To determine risk factors for acute kidney injury (AKI) in preterm infants as a function of time of onset.
  
  
  
  In this 5 1/2-year, single-center, retrospective study, incidence and timing of AKI was determined using modified Acute Kidney Injury Network criteria. Characteristics of newborns with and without AKI were compared by chi square and t-tests. Logistic regression was used to examine risk factors for AKI as a function of time of onset and potential confounders.
  
  
  
  AKI occurred in 30.3% of 357 neonates; 72.2% was stage 1. Gestational ages (GA), initial Cr, maternal magnesium and volume resuscitation were associated with early AKI (days 0 to 1). Volume resuscitation, umbilical arterial line and receipt of non-steroidal anti-inflammatory drug (NSAID) for patent ductus arteriosus were associated with intermediate AKI (days 2 to 5). GA, steroids for early hypotension, necrotizing enterocolitis and sepsis were associated with late AKI (⩾day 6).
  
  
  
  Stage 1 AKI is a common morbidity in our population. Risk factors for AKI in our population differed with time of onset.
authors.affiliation: Division of Newborn Medicine, Department of Pediatrics, Kravis Children's Hospital, Mount Sinai Medical Center, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Weintraub
authors.affiliation: Division of Newborn Medicine, Department of Pediatrics, Kravis Children's Hospital, Mount Sinai Medical Center, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: J
authors.initials: J
authors.lastname: Connors
authors.affiliation: The Department of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Carey
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
authors.forename: V
authors.initials: V
authors.lastname: Blanco
authors.affiliation: Division of Newborn Medicine, Department of Pediatrics, Kravis Children's Hospital, Mount Sinai Medical Center, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Green
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D017668:Age of Onset; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy / Q000453:epidemiology; D020345:Enterocolitis, Necrotizing / Q000453:epidemiology*; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology; D019102:Infant, Very Low Birth Weight; D008297:Male; D062072:Patient Acuity; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology / Q000628:therapy; D013223:Statistics as Topic; D014481:United States / Q000453:epidemiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal