title: Intraoperative navigation in robotically assisted compartmental surgery of uterine cancer by visualisation of embryologically derived lymphatic networks with indocyanine-green (ICG).
abstract: OBJECTIVE
  To evaluate feasibility of intraoperative visualization of embryologically defined organ compartments and their drainage by ICG in uterine cancer.
  
  
  METHODS
  Total of 2.5 mg of ICG have been injected into cervix or corpus in uterine cancer patients immediately prior to surgery. Green fluorescence was intermittently detected during robotically assisted laparoscopic surgery (Firefly System®, Intuitve Surgical Inc.). Total of 36 patients with uterine cancer without macroscopically suspicious nodes were evaluated with respect to their compartmental lymphatic network, collecting lymphatic vessels, and the connection to the postponed lymph basins.
  
  
  RESULTS
  Müllerian (sub) compartment and transport of lymph fluid along the lymphatic collectors and connecting vessels to the postponed lymph basins could be visualized invariably in all patients. Cervix drained along the ligamentous and caudal part of vascular mesometria, whereas midcorporal and fundal drainage occurred along the upper part of vascular mesometria and along the mesonephric pathway along the ovarian vessels.
  
  
  CONCLUSIONS
  Visualization of lymphatic network and downstream flow of lymphatic fluid to the postponed lymph basins by ICG is feasible; it can be used to navigate along compartment boarders for education, intraoperative orientation, and quality control. It seems to confirm the compartmental order of pelvic organ systems and postponed lymph basins. J. Surg. Oncol. 2016;113:554-559. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Gynecology and Obstetrics, West-German Tumor Center, University of Duisburg-Essen, Essen, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Kimmig
authors.affiliation: Department of Gynecology and Obstetrics, West-German Tumor Center, University of Duisburg-Essen, Essen, Germany.
authors.forename: Bahriye
authors.initials: B
authors.lastname: Aktas
authors.affiliation: Department of Gynecology and Obstetrics, West-German Tumor Center, University of Duisburg-Essen, Essen, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Buderath
authors.affiliation: Department of Gynecology and Obstetrics, West-German Tumor Center, University of Duisburg-Essen, Essen, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Rusch
authors.affiliation: Department of Gynecology and Obstetrics, West-German Tumor Center, University of Duisburg-Essen, Essen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Heubner
mesh_terms: D000328:Adult; D004396:Coloring Agents; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007208:Indocyanine Green; D007430:Intraoperative Care; D010535:Laparoscopy; D008197:Lymph Node Excision; D042601:Lymphatic Vessels / Q000000981:diagnostic imaging*; D008875:Middle Aged; D061848:Optical Imaging; D065287:Robotic Surgical Procedures; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green
keywords: cervical cancer; endometrial cancer; intraoperative procedures; radical hysterectomy; robotic surgery