title: Higher Blood Cobalt and Chromium Levels in Patients With Unilateral Metal-on-Metal Total Hip Arthroplasties Compared to Hip Resurfacings.
abstract: Adverse soft tissue reactions in metal-on-metal (MoM) hip replacements are associated with cobalt (Co) and chromium (Cr) ions in blood. We report the prevalence and risk factors for elevated blood Co and Cr levels in patients with a unilateral MoM hip.
  
  
  
  From a single institution, blood Co and Cr levels were analyzed in 1748 patients (692 hip resurfacings and 1056 total hip arthroplasties [THAs]). Concentrations exceeding 7 ppb were considered elevated, and the risk factors for elevated levels were calculated with binary logistic regression.
  
  
  
  Elevated blood metal ion levels were more common in MoM THA than in resurfacing patients (17.4% vs 5.9%, P < .001), and in 5 of the 7 THA brands, more than 20% of patients had elevated metal ion concentrations, whereas the proportion was less than 10% in all hip resurfacings. In resurfacings, small femoral head (odds ratio [OR] 1.30 per millimeter decrease [CI, 1.12-1.49]), high acetabular inclination (OR 1.15 per degree increase [CI 1.09-1.22]), and young age (OR 1.05 per year decrease [1.02-1.10]) were independent risk factors for elevated ions. In the THA group, female gender (OR 2.04 [CI 1.35-3.06]), longer time between surgery and ion measurement (OR 1.19 per year increase [CI 1.05-1.34]), and large headsize (OR 1.07 per millimeter increase [CI 1.01-1.13]) were risk factors for elevated ions.
  
  
  
  Given the high percentage of elevated levels, the systematic surveillance of especially large diameter MoM THAs seems justified.
authors.affiliation: Coxa Hospital for Joint Replacement, Tampere, Finland.
authors.forename: Olli S
authors.initials: OS
authors.lastname: Lainiala
authors.affiliation: Coxa Hospital for Joint Replacement, Tampere, Finland.
authors.forename: Teemu P S
authors.initials: TPS
authors.lastname: Moilanen
authors.affiliation: University College London and the Royal National Orthopaedic Hospital, London, UK.
authors.forename: Alister J
authors.initials: AJ
authors.lastname: Hart
authors.affiliation: University of Tampere, School of Health Sciences, Tampere, Finland.
authors.forename: Heini S A
authors.initials: HSA
authors.lastname: Huhtala
authors.affiliation: University College London and the Royal National Orthopaedic Hospital, London, UK.
authors.forename: Shiraz A
authors.initials: SA
authors.lastname: Sabah
authors.affiliation: Coxa Hospital for Joint Replacement, Tampere, Finland.
authors.forename: Antti P
authors.initials: AP
authors.lastname: Eskelinen
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D002857:Chromium / Q000097:blood*; D003035:Cobalt / Q000097:blood*; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007477:Ions; D008297:Male; D061825:Metal-on-Metal Joint Prostheses / Q000009:adverse effects*; D008670:Metals; D008875:Middle Aged; D015999:Multivariate Analysis; D016059:Range of Motion, Articular; D012307:Risk Factors
chemical_list: D007477:Ions; D008670:Metals; D002857:Chromium; D003035:Cobalt
keywords: blood; chromium; cobalt; metal-on-metal; resurfacing; total hip arthroplasty