title: GeneValidator: identify problems with protein-coding gene predictions.
abstract: : Genomes of emerging model organisms are now being sequenced at very low cost. However, obtaining accurate gene predictions remains challenging: even the best gene prediction algorithms make substantial errors and can jeopardize subsequent analyses. Therefore, many predicted genes must be time-consumingly visually inspected and manually curated. We developed GeneValidator (GV) to automatically identify problematic gene predictions and to aid manual curation. For each gene, GV performs multiple analyses based on comparisons to gene sequences from large databases. The resulting report identifies problematic gene predictions and includes extensive statistics and graphs for each prediction to guide manual curation efforts. GV thus accelerates and enhances the work of biocurators and researchers who need accurate gene predictions from newly sequenced genomes.
  
  
  
  GV can be used through a web interface or in the command-line. GV is open-source (AGPL), available at https://wurmlab.github.io/tools/genevalidator
  
  
  
  : y.wurm@qmul.ac.uk
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Department of Computer Science, ETH Zürich, Zürich, Switzerland.
authors.forename: Monica-Andreea
authors.initials: MA
authors.lastname: Drăgan
authors.affiliation: School of Biological and Chemical Sciences, Queen Mary University of London, London, UK and.
authors.forename: Ismail
authors.initials: I
authors.lastname: Moghul
authors.affiliation: School of Biological and Chemical Sciences, Queen Mary University of London, London, UK and.
authors.forename: Anurag
authors.initials: A
authors.lastname: Priyam
authors.affiliation: Departamento de Psiquiatría y Salud Mental, University of Concepción, Concepción, Chile.
authors.forename: Claudio
authors.initials: C
authors.lastname: Bustos
authors.affiliation: School of Biological and Chemical Sciences, Queen Mary University of London, London, UK and.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Wurm
mesh_terms: D030541:Databases, Genetic; D005796:Genes; D011237:Predictive Value of Tests; D011506:Proteins / Q000235:genetics*; D012984:Software
chemical_list: D011506:Proteins