title: Rapid Tolerance to Constipating Effects of Loperamide in Healthy Subjects.
authors.affiliation: Department of Clinical Pharmacology, Center of Drug Absorption and Transport, University Medicine, Greifswald, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Kolbow
authors.affiliation: Department of Pharmaceutical Technology and Biopharmacy, Center of Drug Absorption and Transport, University of Greifswald, Greifswald, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Weitschies
authors.affiliation: Department of Clinical Pharmacology, Center of Drug Absorption and Transport, University Medicine, Greifswald, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Siegmund
mesh_terms: D003248:Constipation; D064368:Healthy Volunteers; D006801:Humans; D008139:Loperamide; D009271:Naltrexone / Q000627:therapeutic use
chemical_list: D009271:Naltrexone; D008139:Loperamide
keywords: experimental constipation; extended-release; loperamide; methylnaltrexone