title: Evaluation of cardiovascular disease risk in women with surgically induced menopause.
abstract: OBJECTIVE
  This study evaluates cardiovascular disease (CVD) risk among women undergoing natural menopause or surgically induced menopause through the measurement of serum growth differentiation factor-15 (GDF-15), B-type natriuretic peptide (BNP), ischemia modified albumin (IMA), total cholesterol, LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglyceride, fibrinogen, and C-reactive protein (CRP).
  
  
  METHODS
  The study included women with surgically induced menopause (n = 50) and women undergoing natural menopause (n = 50). The two study groups were matched according to age, body mass index, menopause duration. GDF-15, BNP, IMA, total cholesterol, LDL-C, HDL-C, triglyceride, fibrinogen, and CRP were measured.
  
  
  RESULTS
  There was no significant difference in GDF-15, BNP, IMA, total cholesterol, LDL-C, HDL-C, triglyceride, fibrinogen, and CRP results between the two groups.
  
  
  CONCLUSIONS
  We conclude that there is no increase in CVD risk among women aged 40-50 with surgically induced menopause relative to matched control subjects undergoing normal age-related menopause.
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Bozok University , Yozgat , Turkey .
authors.forename: Nagihan
authors.initials: N
authors.lastname: Sari
authors.affiliation: b Department of Obstetrics and Gynecology , Zekai Tahir Burak Training and Research Hospital , Ankara , Turkey , and.
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Üstün
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Bozok University , Yozgat , Turkey .
authors.forename: Emel
authors.initials: E
authors.lastname: Kiyak Çağlayan
authors.affiliation: c Department of Biochemistry , Faculty of Medicine, Bozok University , Yozgat , Turkey.
authors.forename: Ayşe Yeşim
authors.initials: AY
authors.lastname: Göçmen
authors.affiliation: c Department of Biochemistry , Faculty of Medicine, Bozok University , Yozgat , Turkey.
authors.forename: Muhammet Fevzi
authors.initials: MF
authors.lastname: Polat
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D055436:Growth Differentiation Factor 15 / Q000097:blood; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008593:Menopause / Q000097:blood*; D008594:Menopause, Premature / Q000097:blood*; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010052:Ovariectomy / Q000009:adverse effects*; D012306:Risk; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15; D012709:Serum Albumin; D014280:Triglycerides; C561522:ischemia-modified albumin; D020097:Natriuretic Peptide, Brain; D005340:Fibrinogen; D002097:C-Reactive Protein; D000075462:Serum Albumin, Human
keywords: Cardiovascular risk; natural menopause; surgical menopause