title: Nanosilver coated orthodontic brackets: in vivo antibacterial properties and ion release.
abstract: Silver nanoparticles are currently utilized in the fields of dentistry. The aim of this study was to evaluate the antibacterial properties and ion release of nanosilver coated orthodontic brackets compared to conventional brackets.
  
  
  
  Nanosilver coating process was applied to standard orthodontic brackets placed on the mandibular incisors of Wistar Albino rats in the study group and conventional brackets in the control group. Dental plaque, mucosal vestibular smears, saliva, and blood samples were collected from rats at various days. The amounts of nanosilver ions in blood and saliva were measured and microbiological evaluation was made for Streptococcus mutans. For testing cariogenicity, all rats were sacrificed at the end of 75 days under anaesthesia. Teeth were stained using a caries indicator, then the caries ratio was assessed.
  
  
  
  Nanosilver coated orthodontic bracket favoured the inhibition of S.mutans on Day 30 and reduction of caries on the smooth surfaces. The nanosilver amounts in the saliva and serum samples were significantly higher in the study group on Day 7.
  
  
  
  It is suggested that nanosilver coated orthodontic brackets, as an antibacterial agent without patient compliance, could be helpful for the prevention of white spot lesions during fixed orthodontic treatment.
authors.affiliation: Departments of Orthodontics and gamgursoy@gmail.com.
authors.forename: Gamze
authors.initials: G
authors.lastname: Metin-Gürsoy
authors.affiliation: Departments of Orthodontics and.
authors.forename: Lale
authors.initials: L
authors.lastname: Taner
authors.affiliation: Medical Microbiology, Faculty of Dentistry, Gazi University, Ankara, Turkey.
authors.forename: Gülçin
authors.initials: G
authors.lastname: Akca
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000382:microbiology*; D006801:Humans; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D016910:Orthodontic Brackets / Q000382:microbiology*; D051381:Rats; D017208:Rats, Wistar; D012463:Saliva / Q000382:microbiology*; D012834:Silver / Q000737:chemistry*; D013295:Streptococcus mutans / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; C586932:colloidal silver; D012834:Silver