title: Diffusion-weighted MR imaging of uterine leiomyomas following uterine artery embolization.
abstract: OBJECTIVE
  To test whether variations in apparent diffusion coefficient (ADC) values of uterine leiomyomas after uterine artery embolization (UAE) may correlate with outcome and assess the effects of UAE on leiomyomas and normal myometrium with magnetic resonance imaging (MRI).
  
  
  METHODS
  Data of 49 women who underwent pelvic MRI before and after UAE were retrospectively reviewed. Uterine and leiomyoma volumes, ADC values of leiomyomas, and normal myometrium were calculated before and after UAE.
  
  
  RESULTS
  By comparison with baseline ADC values, a significant drop in leiomyoma ADC was found at 6-month post-UAE (1.096 × 10(-3) mm(2)/s vs. 0.712 × 10(-3) mm(2)/s, respectively; p < 0.0001), but not at 48-h post-UAE. Leiomyoma devascularization was complete in 40/49 women (82 %) at 48 h and in 37/49 women (76 %) at 6 months. Volume reduction and leiomyoma ADC values at 6 months correlated with the degree of devascularization. There was a significant drop in myometrium ADC after UAE. Perfusion defect of the myometrium was observed at 48 h in 14/49 women (28.5 %) in association with higher degrees of leiomyoma devascularization.
  
  
  CONCLUSIONS
  Six months after UAE, drop in leiomyoma ADC values and volume reduction correlate with the degree of leiomyoma devascularization. UAE affects the myometrium as evidenced by a drop in ADC values and initial myometrial perfusion defect.
  
  
  CONCLUSIONS
  • A drop in leiomyoma ADC values is observed 6 months after UAE. • Drop in leiomyoma ADC value is associated with leiomyoma devascularizarion after UAE. • MR 48 h post-UAE allows assessing leiomyoma devascularization. • Myometrium perfusion defect occurs more often in women with a smaller uterus.
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Sutter
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.|Université Paris-Diderot, Sorbonne Paris Cité, 10 rue de Verdun, 75010, Paris, France.|UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Soyer
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.
authors.forename: Eimad
authors.initials: E
authors.lastname: Shotar
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.|Université Paris-Diderot, Sorbonne Paris Cité, 10 rue de Verdun, 75010, Paris, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Dautry
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.
authors.forename: Youcef
authors.initials: Y
authors.lastname: Guerrache
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.
authors.forename: Vinciane
authors.initials: V
authors.lastname: Placé
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.
authors.forename: Raluca
authors.initials: R
authors.lastname: Opréa
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Lariboisière-AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Ricbourg
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Le Dref
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.
authors.forename: Mourad
authors.initials: M
authors.lastname: Boudiaf
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France.|Université Paris-Diderot, Sorbonne Paris Cité, 10 rue de Verdun, 75010, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Sirol
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France. anthony.dohan@aphp.fr.|Université Paris-Diderot, Sorbonne Paris Cité, 10 rue de Verdun, 75010, Paris, France. anthony.dohan@aphp.fr.|UMR INSERM 965, Hôpital Lariboisière, 2 rue Amboise Paré, 75010, Paris, France. anthony.dohan@aphp.fr.
authors.forename: Anthony
authors.initials: A
authors.lastname: Dohan
mesh_terms: D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging; D007889:Leiomyoma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D009215:Myometrium / Q000098:blood supply; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D016896:Treatment Outcome; D055357:Uterine Artery Embolization / Q000379:methods*; D014594:Uterine Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*
keywords: Diffusion-weighted imaging; Leiomyomas; Magnetic resonance imaging; Myometrium ischemia; Uterine artery embolization