title: Wearable scanning photoacoustic brain imaging in behaving rats.
abstract: A wearable scanning photoacoustic imaging (wPAI) system is presented for noninvasive brain study in behaving rats. This miniaturized wPAI system consists of four pico linear servos and a single transducer-based PAI probe. It has a dimension of 50 mm × 35 mm × 40 mm, and a weight of 26 g excluding cablings. Phantom evaluation shows that wPAI achieves a lateral resolution of ∼0.5 mm and an axial resolution of ∼0.1 mm at a depth of up to 11 mm. Its imaging ability is also tested in a behaving rat, and the results indicate that wPAI is able to image blood vessels at a depth of up to 5 mm with intact scalp and skull. With its noninvasive, deep penetration, and functional imaging ability in behaving animals, wPAI can be used for behavior, cognition, and preclinical brain disease studies.
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Tang
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Xianjin
authors.initials: X
authors.lastname: Dai
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA. hjiang@bme.ufl.edu.
authors.forename: Huabei
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D059906:Neuroimaging / Q000295:instrumentation*; D019047:Phantoms, Imaging; D051381:Rats; D012886:Skull; D014159:Transducers
keywords: brain imaging; imaging in behaving rats; photoacoustic imaging; scanning photoacoustic imaging