title: Topologically controlled hyaluronan-based gel coatings of hydrophobic grid-like scaffolds to modulate drug delivery.
abstract: Scaffolds based on poly(ethyl acrylate) having interwoven channels were coated with a hyaluronan (HA) hydrogel to be used in tissue engineering applications. Controlled typologies of coatings evolving from isolated aggregates to continuous layers, which eventually clog the channels, were obtained by using hyaluronan solutions of different concentrations. The efficiency of the HA loading was determined using gravimetric and thermogravimetric methods, and the hydrogel loss during the subsequent crosslinking process was quantified, seeming to depend on the mass fraction of hyaluronan initially incorporated to the pores. The effect of the topologically different coatings on the scaffolds, in terms of mechanical properties and swelling at equilibrium under different conditions was evaluated and correlated with the hyaluronan mass fraction. The potential of these hydrogel coatings as vehicle for controlled drug release from the scaffolds was validated using a protein model.
authors.affiliation: Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, C. de Vera s/n, 46022 Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Arnal-Pastor
authors.affiliation: Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, C. de Vera s/n, 46022 Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pérez-Garnes
authors.affiliation: Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, C. de Vera s/n, 46022 Valencia, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Monleón Pradas
authors.affiliation: Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, C. de Vera s/n, 46022 Valencia, Spain. Electronic address: avalles@ter.upv.es.
authors.forename: A
authors.initials: A
authors.lastname: Vallés Lluch
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D006820:Hyaluronic Acid / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D057927:Hydrophobic and Hydrophilic Interactions; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D013818:Thermogravimetry; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; C478961:poly(ethylacrylate); D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D012710:Serum Albumin, Bovine; D006820:Hyaluronic Acid
keywords: Controlled release; Hyaluronan; Hydrogel coating; Poly(ethyl acrylate); Scaffold