title: First transplantation of cryopreserved ovarian tissue in Portugal, stored for 10 years: an unexpected indication.
abstract: Ovarian tissue cryopreservation represents a valid strategy to preserve ovarian function in patients with a high risk of premature ovarian failure. We present a case of ovarian tissue cryopreservation carried out in an 18-year-old woman after a laparotomy for left adnexal mass with left adnexectomy. Congenital absence of the right ovary was observed during surgery. To preserve fertility, rescue cryopreservation of ovarian tissue was carried out under extreme conditions (without adopting the standard published protocol, not yet available at our centre). Ten years later, transplantation of cryopreserved ovarian tissue was carried out and, shortly after it, restoration of ovarian function was confirmed.
authors.affiliation: Unit of Reproductive Medicine, Department of Gynecology and Obstetrics, Hospital Center São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. Electronic address: amargpf@gmail.com.
authors.forename: Ana
authors.initials: A
authors.lastname: Póvoa
authors.affiliation: Unit of Reproductive Medicine, Department of Gynecology and Obstetrics, Hospital Center São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: Pedro
authors.initials: P
authors.lastname: Xavier
authors.affiliation: Unit of Reproductive Medicine, Department of Gynecology and Obstetrics, Hospital Center São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: Lucinda
authors.initials: L
authors.lastname: Calejo
authors.affiliation: Unit of Reproductive Medicine, Department of Gynecology and Obstetrics, Hospital Center São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: Sandra
authors.initials: S
authors.lastname: Soares
authors.affiliation: Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Multidisciplinary Unit for Biomedical Research-UMIB, ICBAS-UP, 4050-313 Porto, Portugal.
authors.forename: Mário
authors.initials: M
authors.lastname: Sousa
authors.affiliation: Unit of Reproductive Medicine, Department of Gynecology and Obstetrics, Hospital Center São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: Joaquina
authors.initials: J
authors.lastname: Silva
authors.affiliation: Unit of Reproductive Medicine, Department of Gynecology and Obstetrics, Hospital Center São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: Sónia
authors.initials: S
authors.lastname: Sousa
authors.affiliation: Department of Genetics, Faculty of Medicine, University of Porto. Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; Institute of Health Research an Innovation, University of Porto, Portugal.
authors.forename: Alberto
authors.initials: A
authors.lastname: Barros
authors.affiliation: Unit of Reproductive Medicine, Department of Gynecology and Obstetrics, Hospital Center São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: Jorge
authors.initials: J
authors.lastname: Beires
mesh_terms: D000293:Adolescent; D000328:Adult; D015925:Cryopreservation; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D010053:Ovary / Q000473:pathology / Q000637:transplantation*; D011174:Portugal; D013997:Time Factors; D014021:Tissue Preservation
keywords: Cryopreserved ovarian tissue; Fertility preservation; Ovarian tissue transplantation