title: Multicarboxylic acids as environment-friendly solvents and in situ crosslinkers for chitosan/PVA nanofibers with tunable physicochemical properties and biocompatibility.
abstract: Monocarboxylic acids are common solvents for chitosan to fabricate nanofibers however the unpleasant odor and the additional step of fiber stabilization using crosslinkers, which might cause toxicity, are always the points to be aware of. The present work demonstrates the potential use of multicarboxylic acids as environment-friendly solvents and in situ crosslinking agents for chitosan electrospinning. The use of these solvents leads to the tunable physicochemical properties, cellular compatibility, and cost effective production. By changing di-, to tri-, and tetracarboxylic acids combining with the simple thermal treatment, the stability and mechanical properties of the nanofibrous mats, especially the elastic modulus and elongation at break, can be altered. The resulting nanofibers exhibit biocompatibility favorable for proliferation and adhesion of the osteoblast cells. The multicarboxylic acids allow us lab-scale reproducibility and possibility to semi-production of nanofibrous chitosan using Nanospider™.
authors.affiliation: National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency, Thailand Science Park, Paholyothin Rd., Pathum thani, 12120 Thailand. Electronic address: autchara@nanotec.or.th.
authors.forename: Autchara
authors.initials: A
authors.lastname: Pangon
authors.affiliation: National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency, Thailand Science Park, Paholyothin Rd., Pathum thani, 12120 Thailand.
authors.forename: Somsak
authors.initials: S
authors.lastname: Saesoo
authors.affiliation: National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency, Thailand Science Park, Paholyothin Rd., Pathum thani, 12120 Thailand.
authors.forename: Nattika
authors.initials: N
authors.lastname: Saengkrit
authors.affiliation: National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency, Thailand Science Park, Paholyothin Rd., Pathum thani, 12120 Thailand.
authors.forename: Uracha
authors.initials: U
authors.lastname: Ruktanonchai
authors.affiliation: National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency, Thailand Science Park, Paholyothin Rd., Pathum thani, 12120 Thailand.
authors.forename: Varol
authors.initials: V
authors.lastname: Intasanta
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry* / Q000633:toxicity; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D002264:Carboxylic Acids; D012997:Solvents; D011142:Polyvinyl Alcohol; D048271:Chitosan
keywords: Chitosan; Crosslinking; Electrospinning; Environment-friendly solvent; Multicarboxylic acid