title: Pancreatic cancer: Current research and future directions.
abstract: Despite the survival rate advancements in different types of cancer in the last 40 years, the perspective for pancreatic cancer patients has seen no substantial changes. Indeed, the five year survival rate remains around 5%. Nevertheless, in the last decade we have witnessed an increased interest in pancreatic cancer biology and this has produced a substantial increment in our knowledge on pancreatic cancer progression. The big challenge is now to translate this knowledge in better outcomes for patients. The aim of this review is to describe the latest discoveries and advancements in pancreatic cancer research and to discuss future directions.
authors.affiliation: Metabolic Signalling Group, School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, Western Australia, Australia. Electronic address: marco.falasca@curtin.edu.au.
authors.forename: Marco
authors.initials: M
authors.lastname: Falasca
authors.affiliation: Metabolic Signalling Group, School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, Western Australia, Australia.
authors.forename: Minkyoung
authors.initials: M
authors.lastname: Kim
authors.affiliation: Metabolic Signalling Group, School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, Western Australia, Australia.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Casari
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology; D055354:Exosomes; D006801:Humans; D035683:MicroRNAs / Q000502:physiology; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology*; D017154:Stromal Cells / Q000502:physiology; D059016:Tumor Microenvironment
chemical_list: D035683:MicroRNAs
keywords: Cancer metabolism; Exosomes; MicroRNA; Pancreatic cancer; Tumour stroma