title: Positron emission tomography response criteria in solid tumours criteria for quantitative analysis of [18F]-fluorodeoxyglucose positron emission tomography with integrated computed tomography for treatment response assessment in metastasised solid tumours: All that glitters is not gold.
abstract: For solid tumours, quantitative analysis of [(18)F]-fluorodeoxyglucose positron emission tomography with integrated computed tomography potentially can have significant value in early response assessment and thereby discrimination between responders and non-responders at an early stage of treatment. Standardised strategies for this analysis have been proposed, and the positron emission tomography response criteria in solid tumours (PERCIST) criteria can be regarded as the current standard to perform quantitative analysis in a research setting, yet is not implemented in daily practice. However, several exceptions and limitations limit the feasibility of PERCIST criteria. In this article, we point out dilemmas that arise when applying proposed criteria like PERCIST on an expansive set of patients with metastasised solid tumours. Clinicians and scientists should be aware of these limitations to prevent that methodological issues impede successful introduction of research data into clinical practice. Therefore, to deliver on the high potential of quantitative imaging, consensus should be reached on a standardised, feasible and clinically useful analysis methodology. This methodology should be applicable in the majority of patients, tumour types and treatments.
authors.affiliation: Radboud university medical center, Department of Medical Oncology, P.O. Box 9101, Nijmegen, The Netherlands. Electronic address: Annelieke.willemsen@radboudumc.nl.
authors.forename: Annelieke E C A B
authors.initials: AECAB
authors.lastname: Willemsen
authors.affiliation: Radboud university medical center, Department of Medical Oncology, P.O. Box 9101, Nijmegen, The Netherlands.
authors.forename: Myrella
authors.initials: M
authors.lastname: Vlenterie
authors.affiliation: Radboud university medical center, Department of Medical Oncology, P.O. Box 9101, Nijmegen, The Netherlands.
authors.forename: Carla M L
authors.initials: CML
authors.lastname: van Herpen
authors.affiliation: Radboud university medical center, Department of Pharmacy, P.O. Box 9101, Nijmegen, The Netherlands.
authors.forename: Nielka P
authors.initials: NP
authors.lastname: van Erp
authors.affiliation: The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, UK.
authors.forename: Winette T A
authors.initials: WTA
authors.lastname: van der Graaf
authors.affiliation: Leiden University Medical Center, Department of Nuclear Medicine, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
authors.forename: Lioe-Fee
authors.initials: LF
authors.lastname: de Geus-Oei
authors.affiliation: The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, UK.
authors.forename: Wim J G
authors.initials: WJG
authors.lastname: Oyen
mesh_terms: D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D064847:Multimodal Imaging / Q000379:methods*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011857:Radiographic Image Interpretation, Computer-Assisted; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Diagnostic imaging; Fluorodeoxyglucose F18; Molecular imaging; Neoplasms; PERCIST; Positron emission tomography; Response evaluation criteria in solid tumours; Treatment outcome