title: Meniett Therapy for Ménière's Disease: An Updated Meta-analysis.
abstract: OBJECTIVE
  To re-evaluate the efficacy of Meniett therapy for the treatment of Ménière's disease (MD).
  
  
  METHODS
  PubMed, Embase, Cochrane Library, Clinicaltrials.gov, ChiCTR, and the CNKI database were searched for articles in English and Chinese published before August 31, 2015.
  
  
  METHODS
  Included in this meta-analysis were studies that dealt with outcomes of Meniett therapy for the treatment of MD, including randomized controlled clinical trials, case-control studies, and prospective or retrospective cohort studies, with sample sizes of ≥ 10 subjects.
  
  
  METHODS
  Keywords included endolymphatic hydrops, Ménière's disease, pressure, Meniett, and transtympanic micropressure treatment.
  
  
  RESULTS
  Fourteen studies were included, involving a total of 345 MD patients. Data were analyzed using the Meta package in R. Dichotomous outcomes were expressed as risk ratios with 95% confidence intervals, and weighted mean differences with 95% confidence intervals were used to present continuous outcomes. Heterogeneity of the included studies was quantitatively assessed by χ(2) and I tests. Fixed-effects models were used for I(2) <50%; otherwise, random-effects models were used. Funnel plots were constructed to test the publication bias.
  
  
  CONCLUSIONS
  This study showed that Meniett therapy may prevent vertigo attacks and substantially reduce its frequency in MD patients. It may also alleviate the functional deficit. The impact of Meniett therapy on hearing remains uncertain. The optimal effect might maintain for approximately 18 months. This meta-analysis suggested that Meniett therapy may be a useful second-line therapy in the treatment of MD.
authors.affiliation: *Department of Otorhinolaryngology, Union Hospital †Institute of Otorhinolaryngology, Union Hospital ‡Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health §Key Laboratory of Neurological Disorders of Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Su-Lin
authors.initials: SL
authors.lastname: Zhang
authors.forename: Yangming
authors.initials: Y
authors.lastname: Leng
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Shi
authors.forename: Meixia
authors.initials: M
authors.lastname: Lu
authors.forename: Wei-Jia
authors.initials: WJ
authors.lastname: Kong
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000601:surgery*; D062086:Transtympanic Micropressure Treatment / Q000379:methods*; D016896:Treatment Outcome