title: A Case Report of a Carbamazepine Overdose With Focus on Pharmacokinetic Aspects.
abstract: In this article a case of carbamazepine overdose is reported. It is common to use immuno-based methods in the field of therapeutic drug monitoring but it might be difficult to adapt such values to toxicological cases. For carbamazepine overdoses it is recommended also to determine the metabolite carbamazepine-10,11-epoxide. Especially for critical conditions a definite substance identification should be performed. In addition, quantifying main metabolites is recommended for an acute clinical toxicological assessment.
authors.affiliation: Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Mittag
authors.affiliation: Department of Neurology, University of Rostock, Rostock, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Meister
authors.affiliation: Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany.
authors.forename: A M J
authors.initials: AM
authors.lastname: Berg
authors.affiliation: Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany.
authors.forename: U I
authors.initials: UI
authors.lastname: Walther
mesh_terms: D002220:Carbamazepine / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D002606:Charcoal / Q000627:therapeutic use; D016903:Drug Monitoring / Q000379:methods*; D062787:Drug Overdose / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002606:Charcoal; D002220:Carbamazepine; C012227:carbamazepine epoxide