title: Stratifying low level Isoniazid resistance using additional intermediate drug concentration.
abstract: Isoniazid (INH) susceptibility testing for 100 Mycobacterium tuberculosis performed by conventional minimum inhibitory concentration (MIC) method was stratified using additional drug concentrations. Introduction of additional drug concentrations did not greatly improve the discriminatory capacity, but can be used in specialized studies pertaining to cross resistance between structural analogues of INH.
authors.affiliation: Department of Bacteriology, National Institute for Research in Tuberculosis (Formerly Tuberculosis Research Centre), Chetput, Chennai 600 031, India.
authors.forename: Rajagopalan
authors.initials: R
authors.lastname: Lakshmi
authors.affiliation: World Health Organization - India Office, New Delhi, India.
authors.forename: Ranjani
authors.initials: R
authors.lastname: Ramachandran
authors.affiliation: Department of Bacteriology, National Institute for Research in Tuberculosis (Formerly Tuberculosis Research Centre), Chetput, Chennai 600 031, India.
authors.forename: A Syam
authors.initials: AS
authors.lastname: Sundar
authors.affiliation: Department of Statistics, National Institute for Research in Tuberculosis (Formerly Tuberculosis Research Centre), Chetput, Chennai 600 031, India.
authors.forename: Fathima
authors.initials: F
authors.lastname: Rahman
authors.affiliation: Department of Bacteriology, National Institute for Research in Tuberculosis (Formerly Tuberculosis Research Centre), Chetput, Chennai 600 031, India. Electronic address: vanaja_kumar51@yahoo.co.in.
authors.forename: Vanaja
authors.initials: V
authors.lastname: Kumar
keywords: Drug resistance; Isoniazid; M. tuberculosis; Minimum inhibitory concentration