title: Structure and Function of CW Domain Containing Proteins.
abstract: The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensively expressed in vertebrates, vertebrate-infecting parasites and higher plants, where they are often involved in chromatin remodeling, methylation recognition, epigenetic regulation and early embryonic development. Since the first CW domain structure was determined 5 years ago, structures of five CW domains have been solved so far. In this review, we will discuss these recent advances in understanding the identification, definition, structure, and functions of the CW domain containing proteins.
authors.affiliation: Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, PR China. yanliliu81@163.com.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Liu
authors.forename: Shasha
authors.initials: S
authors.lastname: Liu
authors.forename: Xinxin
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Liang
authors.forename: Kashif Rafiq
authors.initials: KR
authors.lastname: Zahid
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.forename: Jinlin
authors.initials: J
authors.lastname: Liu
authors.forename: Lingfu
authors.initials: L
authors.lastname: Deng
authors.forename: Jihong
authors.initials: J
authors.lastname: Yang
authors.affiliation: qichao@mail.ccnu.edu.cn.
authors.forename: Chao
authors.initials: C
authors.lastname: Qi
mesh_terms: D000595:Amino Acid Sequence; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D017124:Conserved Sequence; D003545:Cysteine / Q000737:chemistry; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D005810:Multigene Family; D011485:Protein Binding; D011487:Protein Conformation; D054730:Protein Interaction Domains and Motifs; D013329:Structure-Activity Relationship; D014364:Tryptophan / Q000737:chemistry; D015032:Zinc / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D002352:Carrier Proteins; D006657:Histones; C017800:zinc-binding protein; D014364:Tryptophan; D015032:Zinc; D003545:Cysteine