title: Effect of birth weight on adulthood renal function: A bias-adjusted meta-analytic approach.
abstract: While the association between low birth weight (LBW; <2500 g) and development of adult chronic renal disease (CKD) is inconsistently reported, less information is available regarding association of high birth weight (HBW; ≥4000 g) with CKD. We undertook a systematic review and meta-analysis on studies published before 30 September 2015 and report associations between birth weight and renal function. Blood (glomerular filtration rate (GFR)) and urine (microalbuminuria/albumin excreation rate (AER)/urinary albumin creatinine ratio (ACR)) parameters were used to define CKD. Three different effect size estimates were used (odds ratio, regression coefficient and mean difference). The odds of developing CKD in the life course among those born LBW was 1.77 (95% CI: 1.42, 2.20) times and 1.68 (1.27, 2.33) times, assessed by blood and urine parameters respectively. Higher risk was also observed among Asian and Australian populations (blood: OR 2.68; urine: OR 2.28), individuals aged ≤30 years (blood: OR 2.30; urine: OR 1.26), and ≥50 years (blood: OR 3.66; urine: OR 3.10), people with diabetes (blood: OR 2.51), and aborigines (urine: OR 2.32). There was no significant association between HBW and CKD. For every 1 kg increase in BW, the estimated GFR increased by 2.09 mL/min per 1.73 m(2) (1.33-2.85), and it was negatively associated with LogACR (ß -0.07, 95% CI: -0.14, 0.00). LBW inborn had lower mean GFR -4.62 (-7.10, -2.14) compared with normal BW. Findings of this study suggest that LBW increased the risk of developing CKD, and HBW did not show any significant impact.
authors.affiliation: School of Public Health, The University of Queensland, Brisbane, QLD 4006, Australia.|International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
authors.forename: Sumon Kumar
authors.initials: SK
authors.lastname: Das
authors.affiliation: School of Public Health, The University of Queensland, Brisbane, QLD 4006, Australia.
authors.forename: Munim
authors.initials: M
authors.lastname: Mannan
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
authors.forename: Abu Syed Golam
authors.initials: AS
authors.lastname: Faruque
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
authors.forename: Tahmeed
authors.initials: T
authors.lastname: Ahmed
authors.affiliation: School of Public Health, The University of Queensland, Brisbane, QLD 4006, Australia.|Mater Clinical School, University of Queensland, Brisbane, Australia.|Mater Medical Research Institute, Raymond Terrace, South Brisbane, Qld 4101, Australia.
authors.forename: Harold David
authors.initials: HD
authors.lastname: McIntyre
authors.affiliation: School of Public Health, The University of Queensland, Brisbane, QLD 4006, Australia.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Al Mamun
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000419:Albuminuria; D015415:Biomarkers / Q000652:urine; D001724:Birth Weight; D003404:Creatinine / Q000652:urine; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D044469:Racial Groups; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology*; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003404:Creatinine
keywords: birth weight; meta-analysis; renal function; systematic review