title: Changes in Cerebral Blood Flow and Oxygenation During Induction of General Anesthesia with Sevoflurane Versus Propofol.
abstract: Sevoflurane and propofol are widely used for induction and maintenance of general anesthesia. Although the effects of sevoflurane and propofol on cerebral hemodynamics during maintenance of general anesthesia have been demonstrated, the effects during induction of general anesthesia have still not been clarified. We therefore compared changes in cerebral blood flow (CBF) and oxygenation (CBO) during induction of anesthesia using sevoflurane (group S: n=9) or propofol (group P: n=9). CBF and CBO were evaluated using the following variables: oxy-, deoxy-, and total-hemoglobin (Hb) concentrations and tissue oxygen index (TOI), measured on the forehead by near-infrared spectroscopy. The variables were recorded immediately before administration of sevoflurane or propofol and at every 10 s for 4 min after administration of the induction agent. Patients received 8% sevoflurane in 100% oxygen via an anesthesia mask in group S, and an IV bolus of 2 mg/kg of propofol during oxygenation in group P. We found that oxy-Hb, total-Hb, and TOI were significantly higher in group S than in group P (P>0.05). Changes in deoxy-Hb, MBP, and HR did not differ between the groups. The results of the present study demonstrated that sevoflurane increases CBF and CBO during induction of general anesthesia.
authors.affiliation: Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, 30-1,Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.|Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, 30-1,Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kondo
authors.affiliation: Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, 30-1,Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan. hirose.noriya@nihon-u.ac.jp.
authors.forename: Noriya
authors.initials: N
authors.lastname: Hirose
authors.affiliation: Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, 30-1,Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.|Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, 30-1,Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Maeda
authors.affiliation: Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, 30-1,Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, 30-1,Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Yoshino
authors.affiliation: Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, 30-1,Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006801:Humans; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D015742:Propofol / Q000494:pharmacology*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D010100:Oxygen; D015742:Propofol
keywords: Cerebral blood flow; General anesthesia; Near-infrared spectroscopy; Oxygenation; Sevoflurane, propofol