title: The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma.
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
authors.forename: Simon
authors.initials: S
authors.lastname: Fredholm
authors.affiliation: Division of Dermatology, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Ivan V
authors.initials: IV
authors.lastname: Litvinov
authors.affiliation: Faculty of Medicine and Health Sciences School of Veterinary Medicine and Science, School of Medicine, University of Nottingham, Nottingham, UK.
authors.forename: Nigel P
authors.initials: NP
authors.lastname: Mongan
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
authors.forename: Sarah
authors.initials: S
authors.lastname: Schiele
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
authors.forename: Andreas
authors.initials: A
authors.lastname: Willerslev-Olsen
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
authors.forename: David Leander
authors.initials: DL
authors.lastname: Petersen
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
authors.forename: Thorbjørn
authors.initials: T
authors.lastname: Krejsgaard
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
authors.forename: Nina
authors.initials: N
authors.lastname: Sibbesen
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
authors.forename: Claudia
authors.initials: C
authors.lastname: Nastasi
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Bonefeld
authors.affiliation: Clinical Research Center, Lund University, Malmö, Sweden.
authors.forename: Jenny L
authors.initials: JL
authors.lastname: Persson
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark; Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark.
authors.forename: Per Thor
authors.initials: PT
authors.lastname: Straten
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark; Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark.
authors.forename: Mads Hald
authors.initials: MH
authors.lastname: Andersen
authors.affiliation: Department of Pathology, New York University School of Medicine, New York, New York, USA.
authors.forename: Sergei B
authors.initials: SB
authors.lastname: Koralov
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA.
authors.forename: Mariusz M
authors.initials: MM
authors.lastname: Wasik
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
authors.forename: Carsten
authors.initials: C
authors.lastname: Geisler
authors.affiliation: Division of Dermatology, McGill University Health Center, Montréal, Quebec, Canada.
authors.forename: Denis
authors.initials: D
authors.lastname: Sasseville
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Woetmann
authors.affiliation: Department of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark. Electronic address: ndum@sund.ku.dk.
authors.forename: Niels
authors.initials: N
authors.lastname: Ødum
mesh_terms: D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation; D007378:Interleukins / Q000235:genetics / Q000378:metabolism*; D016399:Lymphoma, T-Cell / Q000378:metabolism*; D048768:MAP Kinase Kinase Kinase 4 / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D010766:Phosphorylation; D034741:RNA, Small Interfering / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*; D000098546:Interleukin-21
chemical_list: D007378:Interleukins; D034741:RNA, Small Interfering; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D048768:MAP Kinase Kinase Kinase 4; C482779:MAP3K4 protein, human; D000098546:Interleukin-21