title: Identification of genes involved in pyrethroid-, propoxur-, and dichlorvos- insecticides resistance in the mosquitoes, Culex pipiens complex (Diptera: Culicidae).
abstract: Culex pipiens pallens and Cx. p. quinquefasciatus are important vectors of many diseases, such as West Nile fever and lymphatic filariasis. The widespread use of insecticides to control these disease vectors and other insect pests has led to insecticide resistance becoming common in these species. In this study, high throughout Illumina sequencing was used to identify hundreds of Cx. p. pallens and Cx. p. quinquefasciatus genes that were differentially expressed in response to insecticide exposure. The identification of these genes is a vital first step for more detailed investigation of the molecular mechanisms involved in insecticide resistance in Culex mosquitoes.
authors.affiliation: Department of Vector Biology and Control, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China. Electronic address: vectorlcx@126.com.
authors.forename: Chun-xiao
authors.initials: CX
authors.lastname: Li
authors.affiliation: Department of Vector Biology and Control, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
authors.forename: Xiao-xia
authors.initials: XX
authors.lastname: Guo
authors.affiliation: Department of Vector Biology and Control, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
authors.forename: Ying-mei
authors.initials: YM
authors.lastname: Zhang
authors.affiliation: Department of Vector Biology and Control, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
authors.forename: Yan-de
authors.initials: YD
authors.lastname: Dong
authors.affiliation: Department of Vector Biology and Control, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xing
authors.affiliation: Department of Vector Biology and Control, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Yan
authors.affiliation: Department of Vector Biology and Control, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Vector Biology and Control, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
authors.forename: Heng-duan
authors.initials: HD
authors.lastname: Zhang
authors.affiliation: Department of Vector Biology and Control, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China. Electronic address: tongyanzhao@126.com.
authors.forename: Tong-yan
authors.initials: TY
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002681:China; D003465:Culex / Q000187:drug effects* / Q000235:genetics*; D004006:Dichlorvos / Q000633:toxicity*; D004199:Disease Vectors; D014644:Genetic Variation; D007305:Insecticide Resistance / Q000235:genetics*; D007306:Insecticides / Q000633:toxicity*; D007814:Larva / Q000187:drug effects; D001074:Propoxur / Q000633:toxicity*; D011722:Pyrethrins / Q000633:toxicity*
chemical_list: D007306:Insecticides; D011722:Pyrethrins; D004006:Dichlorvos; D001074:Propoxur
keywords: Culex pipiens pallens; Culex pipiens quinquefasciatus; Gene; Insecticide resistance