title: Activation of the phosphatidylinositol 3-kinase/Akt pathway by viral interferon regulatory factor 2 of Kaposi's sarcoma-associated herpesvirus.
abstract: Kaposi's sarcoma-associated herpesvirus encodes several genes with sequence homology to cellular interferon regulatory factors. Among these, vIRF2 encoded by ORF K11.1 (short form) or K11 (full-length) participates in caspase-3-mediated inactivation of cellular IRF3 and slightly inhibits caspase-3 activity. Here, we have demonstrated that vIRF2 attenuates the transcriptional activity of forkhead box O3A protein via activation of the PI3K/Akt phosphatidylinositol 3-kinase/Akt pathway, inhibiting FOXO3A-mediated caspase-3 cleavage. Based on the collective findings, we suggest that vIRF2 acts as an activator in PI3K/Akt pathway.
authors.affiliation: Department of Life Science, Dongguk University-Seoul, Goyang, 10326, South Korea.
authors.forename: Yejin
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Life Science, Dongguk University-Seoul, Goyang, 10326, South Korea.
authors.forename: Seho
authors.initials: S
authors.lastname: Cha
authors.affiliation: Department of Life Science, Dongguk University-Seoul, Goyang, 10326, South Korea. Electronic address: tseo@dongguk.edu.
authors.forename: Taegun
authors.initials: T
authors.lastname: Seo
mesh_terms: D000818:Animals; D053148:Caspase 3 / Q000378:metabolism*; D004789:Enzyme Activation; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D057809:HEK293 Cells; D006801:Humans; D050835:Interferon Regulatory Factors; D051379:Mice; D041681:NIH 3T3 Cells; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology; D014764:Viral Proteins
chemical_list: C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors; D050835:Interferon Regulatory Factors; D014764:Viral Proteins; C413486:viral interferon regulatory factors; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D053148:Caspase 3
keywords: Caspase-3; FOXO3A; KSHV; PI3K/Akt pathway; vIRF2