title: CXCL12 G801A polymorphism and susceptibility to glioma: a case‑control study.
abstract: Previous studies have demonstrated that the CXCL12 G801A polymorphism is closely correlated with tumor susceptibility. In addition, the CXCL12/CXCR4 pathway is closely related to proliferation, metastasis, and invasion of glioma. However, the genetic effects of the CXCL12 G801A polymorphism on glioma risk in Chinese populations remain unknown. In this study, we investigated the potential associations between the CXCL12 G801A polymorphism with glioma susceptibility and its clinicopathological characteristics. Frequencies of CXCL12 G801A polymorphic variants between glioma patients (N = 750) and healthy controls (N = 750) were assessed using restriction length fragment polymorphism analysis. The association among the CXCL12 G801A polymorphism, glioma grade (WHO classification), and histological type was also evaluated. Our results showed that patients with glioma had significantly higher frequency of the CXCL12-3' A/A genotypes (P = 0.039) as compared with healthy controls. When stratified by the glioma histology, high-grade glioma patients had significantly higher frequency of the CXCL12-3' A/A genotypes (P = 0.019) as compared with low-grade glioma patients. When stratified by the WHO grade, significantly higher frequency of the CXCL12-3' A/A genotype was observed in stage IV glioma patients (P = 0.037). We conclude that the CXCL12 G801A polymorphism is a risk factor that increases susceptibility to gliomas in a subset of the general Han Chinese population.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: S F
authors.initials: SF
authors.lastname: Chang
authors.affiliation: Department of Neurosurgery, The Third People's Hospital of Luoyang, Luoyang, Henan Province, China.
authors.forename: S L
authors.initials: SL
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, The Third People's Hospital of Luoyang, Luoyang, Henan Province, China.
authors.forename: K M
authors.initials: KM
authors.lastname: Yao
authors.affiliation: Department of Neurosurgery, The Third People's Hospital of Luoyang, Luoyang, Henan Province, China.
authors.forename: R H
authors.initials: RH
authors.lastname: Miao
authors.affiliation: Department of Neurosurgery, The Third People's Hospital of Luoyang, Luoyang, Henan Province, China.
authors.forename: G F
authors.initials: GF
authors.lastname: Liang
authors.affiliation: Department of Neurosurgery, The Third People's Hospital of Luoyang, Luoyang, Henan Province, China.
authors.forename: K M
authors.initials: KM
authors.lastname: Zhang
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D054377:Chemokine CXCL12 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D054377:Chemokine CXCL12