title: 2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors.
abstract: A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the novel compounds possess high inhibitory activity against replication of human cytomegalovirus (AD-169 and Davis strains) in HEL cell cultures. In addition, some of the derivatives proved to be inhibitory against varicella zoster virus.
authors.affiliation: Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Babkov
authors.affiliation: Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.
authors.forename: M P
authors.initials: MP
authors.lastname: Paramonova
authors.affiliation: Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ozerov
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Science, Vavilov Str., 32, Moscow, 119991 , Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Khandazhinskaya
authors.affiliation: Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.affiliation: Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.affiliation: Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.
authors.forename: M S
authors.initials: MS
authors.lastname: Novikov
keywords: antiviral activity; human cytomegalovirus; synthesis; uracil derivatives