title: Biologically Active Oxylipins from Enzymatic and Nonenzymatic Routes in Macroalgae.
abstract: Marine algae are rich and heterogeneous sources of great chemical diversity, among which oxylipins are a well-recognized class of natural products. Algal oxylipins comprise an assortment of oxygenated, halogenated, and unsaturated functional groups and also several carbocycles, varying in ring size and position in lipid chain. Besides the discovery of structurally diverse oxylipins in macroalgae, research has recently deciphered the role of some of these metabolites in the defense and innate immunity of photosynthetic marine organisms. This review is an attempt to comprehensively cover the available literature on the chemistry, biosynthesis, ecology, and potential bioactivity of oxylipins from marine macroalgae. For a better understanding, enzymatic and nonenzymatic routes were separated; however, both processes often occur concomitantly and may influence each other, even producing structurally related molecules.
authors.affiliation: REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira No. 228, Porto 4050-313, Portugal. mariana.nunes.barbosa@gmail.com.
authors.forename: Mariana
authors.initials: M
authors.lastname: Barbosa
authors.affiliation: REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira No. 228, Porto 4050-313, Portugal. valentao@ff.up.pt.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Valentão
authors.affiliation: REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira No. 228, Porto 4050-313, Portugal. pandrade@ff.up.pt.
authors.forename: Paula B
authors.initials: PB
authors.lastname: Andrade
mesh_terms: D006801:Humans; D054883:Oxylipins / Q000737:chemistry / Q000378:metabolism*; D012623:Seawater; D012624:Seaweed / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D054883:Oxylipins
keywords: bioactivity; biosynthesis; macroalgae; oxylipins; phytoprostanes