title: Patient reported outcome measures in chronic obstructive pulmonary disease: Which to use?
abstract: Patient-reported outcomes (PROs), such as symptoms and perceived health status, are essential in chronic obstructive pulmonary disease (COPD) for determining disease severity, impact on daily life, effect of treatment and recovery from exacerbations. This field has evolved rapidly and there are a plethora of instruments assessing different PROs. The aim of this review is to provide an understanding of the concept of PROs in COPD. The PROs reflect important aspects of COPD which have a direct impact on daily life. Common symptoms such as dyspnea, cough, phlegm, anxiety, fatigue, and pain and as well as physical function and the risk for and occurrence of acute exacerbations should be assessed both in the clinic and in research. Besides impact on daily life, some of the PROs are related to disease progress and mortality. Construction of composite variables including different disease specific and generic PROs provide a general estimation of health status.
authors.affiliation: a Department of Clinical Sciences, Division of Respiratory Medicine & Allergology , Lund University , Lund , Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Ekström
authors.affiliation: b Department of Respiratory Medicine, School of Medical Sciences , Örebro University , Örebro , Sweden.
authors.forename: Josefin
authors.initials: J
authors.lastname: Sundh
authors.affiliation: c Lung and Airway Research, The National Institute of Environmental Medicine , Karolinska Institutet , Stockholm , Sweden.
authors.forename: Kjell
authors.initials: K
authors.lastname: Larsson
mesh_terms: D000203:Activities of Daily Living; D017281:Cost of Illness; D018450:Disease Progression; D004417:Dyspnea / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D008168:Lung / Q000503:physiopathology; D000071066:Patient Reported Outcome Measures; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D011788:Quality of Life; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D016896:Treatment Outcome
keywords: COPD; Dyspnea; Exacerbation; Health status; Measurement; PROM; Quality of Life