title: Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine.
abstract: Phytochemicals as dietary constituents are being explored for their cancer preventive properties. Quercetin is a major constituent of various dietary products and recently its anti-cancer potential has been extensively explored, revealing its anti-proliferative effect on different cancer cell lines, both in vitro and in vivo. Quercetin is known to have modulatory effects on cell apoptosis, migration and growth via various signaling pathways. Though, quercetin possesses great medicinal value, its applications as a therapeutic drug are limited. Problems like low oral bioavailability and poor aqueous solubility make quercetin an unreliable candidate for therapeutic purposes. Additionally, the rapid gastrointestinal digestion of quercetin is also a major barrier for its clinical translation. Hence, to overcome these disadvantages quercetin-based nanoformulations are being considered in recent times. Nanoformulations of quercetin have shown promising results in its uptake by the epithelial system as well as enhanced delivery to the target site. Herein we have tried to summarize various methods utilized for nanofabrication of quercetin formulations and for stable and sustained delivery of quercetin. We have also highlighted the various desirable measures for its use as a promising onco-therapeutic agent.
authors.affiliation: Institute for Skeletal Aging &amp; Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Korea. jsnam88@hallym.ac.kr.
authors.forename: Ju-Suk
authors.initials: JS
authors.lastname: Nam
authors.affiliation: Institute for Skeletal Aging &amp; Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Korea. boneresearch@hallym.ac.kr.
authors.forename: Ashish Ranjan
authors.initials: AR
authors.lastname: Sharma
authors.affiliation: Institute for Skeletal Aging &amp; Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Korea. lichbio@gmail.com.
authors.forename: Lich Thi
authors.initials: LT
authors.lastname: Nguyen
authors.affiliation: Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida 203201, India. drchiranjib@yahoo.com.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
authors.affiliation: Institute for Skeletal Aging &amp; Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Korea. microbio.garima@gmail.com.|Amity Institute of Nanotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh 201313, India. microbio.garima@gmail.com.
authors.forename: Garima
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Institute for Skeletal Aging &amp; Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Korea. totalhip@hallym.ac.kr.
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001682:Biological Availability; D049109:Cell Proliferation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D019587:Dietary Supplements; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004337:Drug Carriers; D011794:Quercetin
keywords: anticancer; bioavailability; nanoformulation; oncotherapy; phytochemical; quercetin