title: [Thrombocytosis Associated with Poor Prognosis in Patients with Gastric Cancer].
abstract: BACKGROUND
  Thrombocytosis in patients with cancer is reportedly associated with an increased expression of angiogenic factors and a poor prognosis in some cancer types. The aim of this study was to analyze the clinicopathological significance and prognostic value of platelet counts in patients with gastric cancer.
  
  
  METHODS
  Preoperative platelet counts were measured in 306 patients with gastric cancer who underwent surgery between 2001 and 2010.We used the cut-off level of 250.9×10(3) mL (mean) to define thrombocytosis and then analyzed the correlation between platelet count and clinicopathological factors. The multivariate prognostic value was determined using the Cox proportional hazards model.
  
  
  RESULTS
  Platelet counts were significantly elevated in patients with lymph node metastasis (p=0.0349) and pStage Ⅲdisease (p=0.0326). Adjusting for venous invasion and pStage, multivariate analysis indicated that thrombocytosis as defined in this study was an independent prognostic factor (hazard ratio=1.50, 95%CI: 1.07-2.36, p=0.0402).
  
  
  CONCLUSIONS
  A high platelet count is associated with tumor progression and poor survival in patients with gastric cancer.
authors.affiliation: Division of Digestive Surgery, Dept. of Surgery, Kyoto Prefectural University of Medicine.
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Shoda
authors.forename: Shuhei
authors.initials: S
authors.lastname: Komatsu
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichikawa
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kosuga
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Arita
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Konishi
authors.forename: Ryo
authors.initials: R
authors.lastname: Morimura
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Murayama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shiozaki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kuriu
authors.forename: Hisashi
authors.initials: H
authors.lastname: Ikoma
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010976:Platelet Count; D011379:Prognosis; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology*; D013922:Thrombocytosis / Q000209:etiology*