title: Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins.
abstract: A series of 3-acylhydrazono-4-hydroxycoumarins were synthesized via condensation of 3-acetyl-4-hydroxycoumarin with appropriate hydrazides. The structures of the newly-synthesized compounds were characterized by spectral and elememental analysis or HRMS measurements. Their antioxidant properties were evaluated by using scavenging effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical as well as inhibition of lipid peroxidation. Moreover, their ability to inhibit in vitro soybean lipoxygenase has been investigated. They were found to be capable of rapid inactivation of alkylperoxy radicals.
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. kotali@eng.auth.gr.
authors.forename: Antigoni
authors.initials: A
authors.lastname: Kotali
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. dnasiopoulou@yahoo.gr.
authors.forename: Despina A
authors.initials: DA
authors.lastname: Nasiopoulou
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. tsolerid@chem.auth.gr.
authors.forename: Constantinos A
authors.initials: CA
authors.lastname: Tsoleridis
authors.affiliation: GlaxoSmithKline, 1250 South Collegeville Road, P. O. Box 5089, Collegeville, PA 19426-0989, USA. philip.a.harris@gsk.com.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Harris
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. ckontogi@med.duth.gr.
authors.forename: Christos A
authors.initials: CA
authors.lastname: Kontogiorgis
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. hadjipav@pharm.auth.gr.
authors.forename: Dimitra J
authors.initials: DJ
authors.lastname: Hadjipavlou-Litina
mesh_terms: D015110:4-Hydroxycoumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D016166:Free Radical Scavengers / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010851:Picrates / Q000378:metabolism; D010940:Plant Proteins / Q000037:antagonists & inhibitors; D013025:Glycine max / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D015110:4-Hydroxycoumarins; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors; D010851:Picrates; D010940:Plant Proteins; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: 3-acetyl-4-hydroxycoumarin; DPPH; acyl hydrazones; antioxidants; lipid peroxidation; soybean lipoxygenase; trolox