title: Spatially resolved spectroscopy using tapered stripline NMR.
abstract: Magnetic field B0 gradients are essential in modern Nuclear Magnetic Resonance spectroscopy and imaging. Although RF/B1 gradients can be used to fulfill a similar role, this is not used in common practice because of practical limitations in the design of B1 gradient coils. Here we present a new method to create B1 gradients using stripline RF coils. The conductor-width of a stripline NMR chip and the strength of its radiofrequency field are correlated, so a stripline chip can be tapered to produce any arbitrary shaped B1 field gradient. Here we show the characterization of this tapered stripline configuration and demonstrate three applications: magnetic resonance imaging on samples with nL-μL volumes, reaction monitoring of fast chemical reactions (10(-2)-10(1)s) and the compensation of B0 field gradients to obtain high-resolution spectra in inhomogeneous magnetic fields.
authors.affiliation: Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
authors.forename: Koen C H
authors.initials: KCH
authors.lastname: Tijssen
authors.affiliation: Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
authors.forename: Jacob
authors.initials: J
authors.lastname: Bart
authors.affiliation: Mesa+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands.
authors.forename: Roald M
authors.initials: RM
authors.lastname: Tiggelaar
authors.affiliation: Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
authors.forename: J W G Hans
authors.initials: JWGH
authors.lastname: Janssen
authors.affiliation: Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
authors.forename: Arno P M
authors.initials: APM
authors.lastname: Kentgens
authors.affiliation: Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands. Electronic address: j.vanbentum@nmr.ru.nl.
authors.forename: P Jan M
authors.initials: PJM
authors.lastname: van Bentum
keywords: B(1) imaging; Microfluidics; NMR; RF coil design; RF gradient; Reaction monitoring; Tapered stripline