title: Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium erinaceus.
abstract: A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium erinaceus. Their structures were elucidated by spectroscopic and X-ray analysis. A 30-day oral course of erinacines A and S attenuated Aβ plaque burden in the brains of 5-month-old female APP/PS1 transgenic mice. Moreover, erinacines A and S significantly increased the level of insulin-degrading enzyme in cerebral cortex.
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Institute of Biopharmaceutical Science, National Yang-Ming University , Taipei 112, Taiwan, R.O.C.
authors.forename: Tsai-Teng
authors.initials: TT
authors.lastname: Tzeng
authors.affiliation: Biotechnology Center, Grape King Bio Ltd. , Chung Li, Taoyuan 320, Taiwan, R.O.C.
authors.forename: Chin-Chu
authors.initials: CC
authors.lastname: Chen
authors.forename: Ching-Li
authors.initials: CL
authors.lastname: Ni
authors.affiliation: Biotechnology Center, Grape King Bio Ltd. , Chung Li, Taoyuan 320, Taiwan, R.O.C.
authors.forename: Li-Ya
authors.initials: LY
authors.lastname: Lee
authors.affiliation: Biotechnology Center, Grape King Bio Ltd. , Chung Li, Taoyuan 320, Taiwan, R.O.C.
authors.forename: Wan-Ping
authors.initials: WP
authors.lastname: Chen
authors.affiliation: Institute of Biopharmaceutical Science, National Yang-Ming University , Taipei 112, Taiwan, R.O.C.|National Research Institute of Chinese Medicine, Ministry of Health and Welfare , Peitou, Taipei 112, Taiwan, R.O.C.
authors.forename: Young-Ji
authors.initials: YJ
authors.lastname: Shiao
authors.affiliation: National Research Institute of Chinese Medicine, Ministry of Health and Welfare , Peitou, Taipei 112, Taiwan, R.O.C.
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Shen
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D001921:Brain / Q000201:enzymology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification; D005260:Female; D007339:Insulysin / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D015394:Molecular Structure; D025282:Mycelium / Q000737:chemistry; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013624:Taiwan
chemical_list: D004224:Diterpenes; D054830:Sesterterpenes; C497675:cyathane; C000595639:erinacine A; C000608927:erinacine S; D007339:Insulysin