title: Redox homeostasis, T cells and kidney diseases: three faces in the dark.
abstract: The redox equilibrium is crucial for the maintenance of immune homeostasis. Here, we summarize recent data showing that oxidation regulates T-cell functions and that alterations of the redox equilibrium may play an important role in the pathogenesis of inflammatory conditions affecting the kidneys. We further discuss potential links between oxidation, T cells and renal diseases such as systemic lupus erythematosus, renal ischaemia/reperfusion injury, end-stage renal disease and hypertension. The basic understanding of oxidation as a means by which diseases are directly affected results in unexpected pathophysiological similarities. Finally, we describe potential therapeutic options targeting redox systems for the treatment of nephropathies affecting humans.
authors.affiliation: Otto-von-Guericke University, Institute of Molecular and Clinical Immunology , Magdeburg , Germany.
authors.forename: Luca
authors.initials: L
authors.lastname: Simeoni
authors.affiliation: Otto-von-Guericke University, Institute of Molecular and Clinical Immunology , Magdeburg , Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Thurm
authors.affiliation: Otto-von-Guericke University, Institute of Molecular and Clinical Immunology , Magdeburg , Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kritikos
authors.affiliation: Clinic for Nephrology and Hypertension , Christian-Albrechts-University Kiel , Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Linkermann
keywords: T-cell activation; acute kidney injury; autoimmunity; end-stage kidney disease; systemic lupus erythematosus (SLE)