title: Chromatin-Binding Proteins Moonlight as Mitotic Microtubule Regulators.
abstract: Some microtubule (MT)-associated proteins bind to MTs and chromatin simultaneously to fulfill their mitotic spindle function. By contrast, a growing number of chromatin-binding proteins leave mitotic chromatin and interact with MTs via their chromatin-binding domains. I discuss this switch from chromatin to MT binding as a key regulatory principle of spindle formation.
authors.affiliation: Friedrich Miescher Laboratory of the Max Planck Society, Spemannstrasse 39, 72076 Tuebingen, Germany. Electronic address: hideki.yokoyama@tuebingen.mpg.de.
authors.forename: Hideki
authors.initials: H
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure; D008938:Mitosis; D008941:Spindle Apparatus / Q000378:metabolism
chemical_list: D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D008869:Microtubule-Associated Proteins
keywords: chromatin-binding domains; chromatin-binding proteins; chromatin-remodeling factors; microtubule-associated proteins (MAPs); mitotic spindle; nuclear localization signal (NLS)