title: Nonhuman Primate Ocular Biometry.
abstract: OBJECTIVE
  To examine ocular growth in nonhuman primates (NHPs) from measurements on ex vivo eyes.
  
  
  METHODS
  We obtained NHP eyes from animals that had been killed as part of other studies or because of health-related issues. Digital calipers were used to measure the horizontal, vertical, and anteroposterior globe diameters as well as corneal horizontal and vertical diameters of excised globes from 98 hamadryas baboons, 551 cynomolgus monkeys, and 112 rhesus monkeys, at ages ranging from 23 to 360 months. Isolated lens sagittal thickness and equatorial diameter were measured by shadowphotogrammetry. Wet and fixed dry weights were obtained for lenses.
  
  
  RESULTS
  Nonhuman primate globe growth continues throughout life, slowing toward an asymptotic maximum. The final globe size scales with negative allometry to adult body size. Corneal growth ceases at around 20 months. Lens diameter increases but thickness decreases with increasing age. Nonhuman primate lens wet and dry weight accumulation is monophasic, continuing throughout life toward asymptotic maxima. The dry/wet weight ratio reaches a maximum of 0.33.
  
  
  CONCLUSIONS
  Nonhuman primate ocular globe and lens growth differ in several respects from those in humans. Although age-related losses of lens power and accommodative amplitude are similar, lens growth and properties are different indicating care should be taken in extrapolating NHP observations to the study of human accommodation.
authors.affiliation: Vision Cooperative Research Centre, Sydney, Australia 2School of Optometry and Vision Science, University of New South Wales, Sydney, Australia 3Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miam.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Augusteyn
authors.affiliation: Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States 4Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States.
authors.forename: Bianca
authors.initials: B
authors.lastname: Maceo Heilman
authors.affiliation: Vision Cooperative Research Centre, Sydney, Australia 2School of Optometry and Vision Science, University of New South Wales, Sydney, Australia 3Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miam.
authors.forename: Arthur
authors.initials: A
authors.lastname: Ho
authors.affiliation: Vision Cooperative Research Centre, Sydney, Australia 3Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States 4Department of Biomedical Engineering, University of Miami Colle.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Parel
mesh_terms: D000375:Aging; D000818:Animals; D001699:Biometry / Q000379:methods*; D003315:Cornea / Q000254:growth & development*; D007908:Lens, Crystalline / Q000254:growth & development*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D048529:Papio hamadryas