title: Na+-K+-ATPase, a new class of plasma membrane receptors.
abstract: The Na(+)-K(+)-ATPase (NKA) differs from most other ion transporters, not only in its capacity to maintain a steep electrochemical gradient across the plasma membrane, but also as a receptor for a family of cardiotonic steroids, to which ouabain belongs. Studies from many groups, performed during the last 15 years, have demonstrated that ouabain, a member of the cardiotonic steroid family, can activate a network of signaling molecules, and that NKA will also serve as a signal transducer that can provide a feedback loop between NKA and the mitochondria. This brief review summarizes the current knowledge and controversies with regard to the understanding of NKA signaling.
authors.affiliation: Science for Life Laboratory, Department of Women and Children's Health, Karolinska Institutet, Stockholm, Sweden; and anita.aperia@ki.se.
authors.forename: Anita
authors.initials: A
authors.lastname: Aperia
authors.affiliation: Science for Life Laboratory, Department of Women and Children's Health, Karolinska Institutet, Stockholm, Sweden; and.
authors.forename: Evgeny E
authors.initials: EE
authors.lastname: Akkuratov
authors.affiliation: Science for Life Laboratory, Department of Applied Physics, Royal Institute of Technology, Stockholm, Sweden.
authors.forename: Jacopo Maria
authors.identifier: http://orcid.org/0000-0003-4784-4713
authors.initials: JM
authors.lastname: Fontana
authors.affiliation: Science for Life Laboratory, Department of Women and Children's Health, Karolinska Institutet, Stockholm, Sweden; and Science for Life Laboratory, Department of Applied Physics, Royal Institute of Technology, Stockholm, Sweden.
authors.forename: Hjalmar
authors.initials: H
authors.lastname: Brismar
mesh_terms: D000818:Animals; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D000254:Sodium-Potassium-Exchanging ATPase
keywords: Na+-K+-ATPase; apoptosis; ouabain; receptor; signaling