title: Epigenetic memory in kidney diseases.
abstract: Epigenetic mechanisms have been the focus of intensive research. De Marinis et al. demonstrated that high glucose levels exert stimulatory effects on activation histone marks, leading to the upregulation of thioredoxin-interacting protein (TXNIP) gene expression, which is proinflammatory. They also showed that the effect was reversed by the inhibition of histone acetyltransferase, suggesting a new therapeutic approach for improving diabetic kidney disease. Epigenetic changes are memorized as epigenetic memory that could exacerbate diabetic complications.
authors.affiliation: Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan. Electronic address: imimura-tky@umin.ac.jp.
authors.forename: Imari
authors.initials: I
authors.lastname: Mimura
mesh_terms: D002352:Carrier Proteins / Q000235:genetics; D048909:Diabetes Complications / Q000235:genetics; D003928:Diabetic Nephropathies; D044127:Epigenesis, Genetic; D057890:Epigenomics; D006801:Humans; D015533:Transcriptional Activation
chemical_list: D002352:Carrier Proteins