title: Electrochemical Gold(III) Sensor with High Sensitivity and Tunable Dynamic Range.
abstract: We report the design and fabrication of a sensitive, specific, and selective electrochemical ion (E-ION) sensor for detection of Au(III). The signaling mechanism is based on the interactions between Au(III) and adenine; formation of these complexes rigidifies the methylene blue (MB)-modified oligoadenine probes, resulting in a concentration-dependent reduction in the MB signal. The dynamic range of the sensor can be tuned by simply changing the length of the DNA probe (six (A6) or 12 (A12) adenines). Independent of the probe length, both sensors have demonstrated to be sensitive, with a limits of detection of 50 and 20 nM for the A6 and A12 sensors, respectively. With further optimization, this sensing strategy may offer a promising approach for analyzing Au(III).
authors.affiliation: University of Nebraska-Lincoln , 651 Hamilton Hall, Lincoln, Nebraska 68588-0304, United States.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wu
authors.affiliation: University of Nebraska-Lincoln , 651 Hamilton Hall, Lincoln, Nebraska 68588-0304, United States.
authors.forename: Rebecca Y
authors.initials: RY
authors.lastname: Lai
mesh_terms: D000225:Adenine / Q000737:chemistry; D015342:DNA Probes / Q000737:chemistry; D055664:Electrochemical Techniques; D006046:Gold / Q000032:analysis*; D008751:Methylene Blue / Q000737:chemistry
chemical_list: D015342:DNA Probes; D006046:Gold; D000225:Adenine; D008751:Methylene Blue