title: A case of biliary adenofibroma with malignant transformation.
abstract: Identifying precursor lesions of cholangiocarcinoma (CC) is relevant for early diagnosis and management. While for distal, perihilar and large duct cholangiocarcinoma, premalignant lesions are being recognized and studied actively, precursors of peripheral CC are still poorly described. Biliary adenofibroma is a rare benign tumor that has been proposed as a possible precursor lesion of peripheral CC. In the present report, we describe a unique case of a peripheral ICC that originated from a benign biliary adenofibroma with areas of atypical papillary proliferation, which is an expression of a multistep process of carcinogenesis.
authors.affiliation: Surgical Pathology Unit, University Hospital of Parma, Parma, Italy. Electronic address: elenathai@yahoo.com.
authors.forename: Elena
authors.initials: E
authors.lastname: Thai
authors.affiliation: General and Transplantation Surgery, University Hospital of Parma, Parma, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Dalla Valle
authors.affiliation: Surgical Pathology Unit, University Hospital of Parma, Parma, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Evaristi
authors.affiliation: Surgical Pathology Unit, University Hospital of Parma, Parma, Italy.
authors.forename: Enrico Maria
authors.initials: EM
authors.lastname: Silini
mesh_terms: D000232:Adenofibroma / Q000473:pathology*; D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000473:pathology*; D006801:Humans; D008297:Male; D011230:Precancerous Conditions / Q000473:pathology
keywords: Biliary adenofibroma; Carcinogenesis; Cholangiocarcinoma; Precursors