title: Evaluation of 5-HT7 receptor expression in the placentae of normal and pre-eclamptic women.
abstract: In this study, by examining 5-HT7 receptor expression in placentae from pre-eclamptic and normal pregnancies, we aimed to discover a new step of pathophysiological cascade for preeclampsia. Patients whose blood pressure over the 140/90 mmHg were included when study after 20 weeks of gestation. 5-HT7 receptor expression was investigated on the placentae obtained after birth by real time PCR (RT-PCR) analysis. Pre-natal-post-natal, systolic-diastolic blood pressure values, proteinuria and renal function indicators as BUN and creatinine levels of pre-eclamptic pregnant women were higher than the healthy group. Similarly, 5-HT7 receptor expression determined in healthy placentae increased 8-fold in pre-eclamptic women. This study, for the first time we showed 5-HT7 receptor expression in normal placenta and increased expression in pre-eclamptic placenta.
authors.affiliation: a Department of Pharmacology , Faculty of Medicine .
authors.forename: Emine
authors.initials: E
authors.lastname: Irge
authors.affiliation: a Department of Pharmacology , Faculty of Medicine .
authors.forename: Zekai
authors.initials: Z
authors.lastname: Halici
authors.affiliation: b Department of Obstetrics and Gynecology , Faculty of Medicine , and.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: a Department of Pharmacology , Faculty of Medicine .
authors.forename: Elif
authors.initials: E
authors.lastname: Cadirci
authors.affiliation: c Department of Pharmacology and Toxicology , Faculty of Veterinary Medicine, Ataturk University , Erzurum , Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Karakus
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001806:Blood Urea Nitrogen; D016022:Case-Control Studies; D003404:Creatinine / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D011507:Proteinuria / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D011985:Receptors, Serotonin / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012709:Serum Albumin / Q000378:metabolism; D055815:Young Adult
chemical_list: D012333:RNA, Messenger; D011985:Receptors, Serotonin; D012709:Serum Albumin; C104425:serotonin 7 receptor; D003404:Creatinine
keywords: 5-HT; 5-HT7 receptor; placenta; pre-eclampsia