title: Gelatin-coated Gold Nanoparticles as Carriers of FLT3 Inhibitors for Acute Myeloid Leukemia Treatment.
abstract: This study presents the design of a gold nanoparticle (AuNPs)-drug system with improved efficiency for the treatment of acute myeloid leukemia. The system is based on four different FLT3 inhibitors, namely midostaurin, sorafenib, lestaurtinib, and quizartinib, which were independently loaded onto gelatin-coated gold nanoparticles. Detailed investigation of the physicochemical properties of the formed complexes lead to the selection of quizartinib-loaded AuNPs for the in vitro evaluation of the biological effects of the formed complex against OCI-AML3 acute myeloid leukemia cells. Viability tests by MTT demonstrated that the proposed drug complex has improved efficacy when compared with the drug alone. The obtained results constitute a premise for further in vivo investigation of such drug vehicles based on AuNPs. To the best of our knowledge, this is the first study that investigates the delivery of the above-mentioned FLT3 inhibitors via gelatin-coated gold nanoparticles.
authors.affiliation: Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, T. Laurian 42, 400271, Cluj-Napoca, Romania.|Faculty of Physics, Babes-Bolyai University, M. Kogalniceanu, 40084.
authors.forename: Sorina
authors.initials: S
authors.lastname: Suarasan
authors.affiliation: Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, T. Laurian 42, 400271, Cluj-Napoca, Romania.|Faculty of Physics, Babes-Bolyai University, M. Kogalniceanu, 40084.
authors.forename: Timea
authors.initials: T
authors.lastname: Simon
authors.affiliation: Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, T. Laurian 42, 400271, Cluj-Napoca, Romania.|Faculty of Physics, Babes-Bolyai University, M. Kogalniceanu, 40084.
authors.forename: Sanda
authors.initials: S
authors.lastname: Boca
authors.affiliation: Department of Hematology, Ion Chiricuta Oncology Institute, Bulevardul 21 Decembrie 1918 Nr 73, 400124, Cluj-Napoca, Romania.|Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, G. Marinescu 23, 400337, Cluj-Napoca, Romania.
authors.forename: Ciprian
authors.initials: C
authors.lastname: Tomuleasa
authors.affiliation: Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, T. Laurian 42, 400271, Cluj-Napoca, Romania.|Faculty of Physics, Babes-Bolyai University, M. Kogalniceanu, 40084.
authors.forename: Simion
authors.initials: S
authors.lastname: Astilean
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D005780:Gelatin / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000201:enzymology; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D008875:Middle Aged; D010671:Phenylurea Compounds / Q000737:chemistry / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D052160:Benzothiazoles; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; C544967:quizartinib; D005780:Gelatin; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3
keywords: cancer; colloid; drug design; drug transport; nanoparticles; nanotechnology