title: Uniportal versus three-port video-assisted thoracoscopic surgery for spontaneous pneumothorax: a meta-analysis.
abstract: BACKGROUND
  Whether or not uniportal video-assisted thoracoscopic surgery (VATS) is beneficial for spontaneous pneumothorax remains inconclusive. This meta-analysis aimed to summarize the available evidence to assess the feasibility and advantages of uniportal VATS for the treatment of spontaneous pneumothorax compared with three-port VATS.
  
  
  METHODS
  Eligible publications were identified by searching the Cochrane Library, PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data databases and CQVIP. Odds ratios (OR) and standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated to compare dichotomous and continuous variables, respectively.
  
  
  RESULTS
  This meta-analysis was based on 17 studies and included a total of 988 patients with spontaneous pneumothorax. No death was reported during the perioperative period. Compared with three-port VATS groups, there was a statistically significant difference in uniportal VATS groups regarding postoperative hospital stay (SMD= -0.58; 95% CI: -1.04 to -0.12; P=0.01), paresthesia (OR=0.13; 95% CI: 0.07 to 0.24; P<0.00001), visual analogue pain score (VAS) at 24 hours (h) (SMD= -0.87; 95% CI: -1.07 to -0.68; P<0.00001), VAS at 72 h (SMD= -0.49; 95% CI: -0.68 to -0.30; P<0.00001), and patients satisfaction scale (PSS) at 24 h (SMD= -0.81; 95% CI: -1.21 to -0.41; P<0.0001), PSS at 48 h (SMD= -0.69; 95% CI: -1.08 to -0.29; P=0.0007). However there was no statistically significant difference on the recurrence (OR=0.79; 95% CI: 0.42 to 1.46; P=0.45), operative time (SMD= -0.23; 95% CI: -0.21 to 0.67; P=0.31), length of postoperative drainage (SMD= -0.17; 95% CI: -0.40 to -0.07; P=0.16), VAS at 48 h (SMD= -0.40; 95% CI: -1.47 to 0.67; P=0.46), and PSS at 72 h (SMD= -0.13; 95% CI: -0.52 to -0.25; P=0.50).
  
  
  CONCLUSIONS
  The results for mortality, recurrence, operative time, and length of postoperative drainage were similar between uniportal and three-port VATS. Uniportal VATS resulted in reduction in postoperative pain and paresthesia as well as an improvement in patients' satisfaction. This meta-analysis indicated that using uniportal VATS to treat spontaneous pneumothorax was safe and feasible, and it may be a better alternative procedure because of its advantage in reducing postoperative pain and paresthesia.
authors.affiliation: 1 Department of Cardiothoracic Surgery, the First Affiliated Hospital of GuangXi Medical University, Nanning 530021, China ; 2 Class 3 in Grade 2009 of GuangXi Medical University, Nanning 530021, China.
authors.forename: Shi-Lei
authors.initials: SL
authors.lastname: Qin
authors.affiliation: 1 Department of Cardiothoracic Surgery, the First Affiliated Hospital of GuangXi Medical University, Nanning 530021, China ; 2 Class 3 in Grade 2009 of GuangXi Medical University, Nanning 530021, China.
authors.forename: Jin-Bo
authors.initials: JB
authors.lastname: Huang
authors.affiliation: 1 Department of Cardiothoracic Surgery, the First Affiliated Hospital of GuangXi Medical University, Nanning 530021, China ; 2 Class 3 in Grade 2009 of GuangXi Medical University, Nanning 530021, China.
authors.forename: Yan-Long
authors.initials: YL
authors.lastname: Yang
authors.affiliation: 1 Department of Cardiothoracic Surgery, the First Affiliated Hospital of GuangXi Medical University, Nanning 530021, China ; 2 Class 3 in Grade 2009 of GuangXi Medical University, Nanning 530021, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xian
keywords: Uniportal; meta-analysis; spontaneous pneumothorax; three-port surgery; video-assisted thoracoscopic surgery (VATS)