title: Antenatal screening for hepatitis B virus in HIV-infected and uninfected pregnant women in the Tshwane district of South Africa.
abstract: BACKGROUND
  Despite enormous strides in preventing hepatitis B virus (HBV) infection, perinatal transmission still contributes significantly to HBV epidemiology worldwide; this could account for approximately 50% of chronically infected individuals.
  
  
  OBJECTIVE
  To assess the need for HBV screening in antenatal clinics in the HIV/AIDS era.
  
  
  METHODS
  This was a retrospective study conducted at the antenatal clinic of 1 Military Hospital, Tshwane, South Africa. Laboratory data for HBV, HIV and CD4 count were obtained and analysed for the period January 2008-December 2013.
  
  
  RESULTS
  A total of 2,513 patients' results were retrieved and 2 368 patients were enrolled as both their HBV and HIV serology results were available. The mean age of participants was 29 years (range 14-46). HIV prevalence in this study was 20.5% (95% confidence interval (CI) 0.189-0.222). The median CD4 count in HIV-infected patients was 522 cells/μL (interquartile range 370-711). There was an overall HBV prevalence of 0.8% (95% CI 0.005-0.011). The hepatitis B surface antigen (HBsAg) prevalence was significantly higher (2.1%) among HIV co-infected compared with HIV-uninfected patients (0.4%) (p=0.0001). Hepatitis e antigen (HBeAg) positivity was 30% in the HIV co-infected compared with 37.6% in the HIV-uninfected individuals (p=0.7400).
  
  
  CONCLUSIONS
  This study showed a significantly higher HBV prevalence in HIV-infected compared with HIV-uninfected patients. The comparable HBeAg prevalence between the two groups indicates that both were at an increased risk of vertical transmission, therefore demonstrating a need for antenatal screening for HBV. Since antenatal screening is often not affordable in low-income countries, administration of HBV vaccine at birth is needed for prevention of vertical transmission.
authors.affiliation: Maternal and Infant Health Care Strategies Unit, Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa. qdiale@hotmail.com.
authors.forename: Q
authors.initials: Q
authors.lastname: Diale
authors.forename: R
authors.initials: R
authors.lastname: Pattinson
authors.forename: R
authors.initials: R
authors.lastname: Chokoe
authors.forename: L
authors.initials: L
authors.lastname: Masenyetse
authors.forename: S
authors.initials: S
authors.lastname: Mayaphi