title: Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy.
abstract: Peptide-tuned self-assembly of functional components offers a strategy towards improved properties and unique functions of materials, but the requirement of many different functions and a lack of understanding of complex structures present a high barrier for applications. Herein, we report a photosensitive drug delivery system for photodynamic therapy (PDT) by a simple dipeptide- or amphiphilic amino-acid-tuned self-assembly of photosensitizers (PSs). The assembled nanodrugs exhibit multiple favorable therapeutic features, including tunable size, high loading efficiency, and on-demand drug release responding to pH, surfactant, and enzyme stimuli, as well as preferable cellular uptake and biodistribution. These features result in greatly enhanced PDT efficacy in vitro and in vivo, leading to almost complete tumor eradication in mice receiving a single drug dose and a single exposure to light.
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
authors.forename: Ruirui
authors.initials: R
authors.lastname: Xing
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.|Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam/Golm, Germany.
authors.forename: Qianli
authors.initials: Q
authors.lastname: Zou
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Ma
authors.affiliation: Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam/Golm, Germany.
authors.forename: Helmuth
authors.initials: H
authors.lastname: Möhwald
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China. yanxh@ipe.ac.cn.
authors.forename: Xuehai
authors.initials: X
authors.lastname: Yan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010455:Peptides / Q000737:chemistry*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013056:Spectrophotometry, Ultraviolet; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; D017319:Photosensitizing Agents
keywords: cooperative self-assembly; nanodrugs; peptides; photodynamic therapy; photosensitizers