title: Long non-coding RNA derived miR-205-5p modulates human endometrial cancer by targeting PTEN.
abstract: OBJECTIVE
  This study was to investigate the roles of lncRNA associated competitive endogenous RNAs (ceRNAs) network in the endometrial cancer (EC).
  
  
  METHODS
  StarbaseV2.0 online software was used to predict the most probable lncRNAs which contain miR-205-5p binding site and are competent to interact with miR-205-5p. Then, lncRNAs which had decreased expression in EC compared with normal endometrium and conformed to the polyadenylated characteristics of lncRNAs were selected and then lncRNAs associated with miR-205-5p-PTEN network were identified.
  
  
  RESULTS
  Two novel genes RP11-395G23.3 and LA16c-313D11.11 associated with endometrial cancer were identified and proved to be non-coding RNAs. They were more effective ceRNAs associated with the miR-205-5p-PTEN network.
  
  
  CONCLUSIONS
  Our results suggest that lncRNAs harbor MREs (miRNA response elements) and play important roles in the post-transcriptional regulation in EC.
authors.affiliation: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University Shanghai 200032, China.
authors.forename: Weijuan
authors.initials: W
authors.lastname: Xin
authors.affiliation: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University Shanghai 200032, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University Shanghai 200032, China.
authors.forename: Jingxin
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University Shanghai 200032, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Regenerative Medicine, Tongji University School of Medicine Shanghai 200092, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Obstetrics and Gynecology, East Hospital of Tongji University Shanghai 200120, China.
authors.forename: Qianyu
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University Shanghai 200032, China.
authors.forename: Keqin
authors.initials: K
authors.lastname: Hua
keywords: endometrial cancer; lncRNA; miR-205-5p; phosphatase and tensin homolog deleted on chromosome ten