title: A protocol to develop clinical guidelines for inclusion-body myositis.
abstract: BACKGROUND
  Inclusion-body myositis (IBM) is a late-onset idiopathic inflammatory myopathy associated with selective and progressive muscle weakness and atrophy. Current clinical management of IBM is largely supportive due to its uncertain etiology and lack of effective treatment. Establishing a consensus of opinion on questions relating to diagnosis and management of IBM is expected to help reduce inconsistencies in the care and resources allocated to those living with this condition.
  
  
  METHODS
  A protocol has been developed to produce best practice clinical guidelines for IBM based on a combination of published research and expert consensus.
  
  
  CONCLUSIONS
  In this study we describe the proposed protocol for developing methods for producing robust and transparent clinical guidance on aspects of diagnosis, drug treatment, physical and practical management, respiration, nutrition and cardiac management, psychosocial management, and multidisciplinary care.
authors.affiliation: Department of Neurology, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Jones
authors.affiliation: Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Thomas
authors.initials: T
authors.lastname: Sejersen
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Amato
authors.affiliation: Department of Neurology, John Radcliffe Hospital, Oxford, UK.
authors.forename: David
authors.initials: D
authors.lastname: Hilton-Jones
authors.affiliation: University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Schmidt
authors.affiliation: MRC Centre for Neuromuscular Diseases, Institute of Neurology, University College London, London, UK.
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Wallace
authors.affiliation: Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: Umesh A
authors.initials: UA
authors.lastname: Badrising
authors.affiliation: Department of Neurology, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Rose
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods; D006801:Humans; D009220:Myositis / Q000175:diagnosis / Q000628:therapy; D018979:Myositis, Inclusion Body / Q000175:diagnosis* / Q000628:therapy*; D017410:Practice Guidelines as Topic / Q000592:standards*
keywords: IBM; diagnosis; guidelines; management; protocol