title: Short-Interval Retreatment With Stereotactic Body Radiotherapy (SBRT) for Pediatric Neuroblastoma Resulting in Severe Myositis.
abstract: We report a severe and not previously reported toxicity after short-interval retreatment with stereotactic body radiotherapy (SBRT) in a pediatric patient with neuroblastoma. This patient experienced Grade III radiation myositis after treatment with conventional radiation therapy followed by high-dose SBRT for persistent disease a short interval after the initial radiotherapy course. While SBRT shows outstanding rates of local control in adult disease, data in pediatric cancers are extremely limited. In this report, we discuss the rationale of SBRT in this patient's multimodality neuroblastoma treatment, management of the toxicity, and future perspectives on the use of SBRT in pediatric cancer.
authors.affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York.
authors.forename: Neil K
authors.initials: NK
authors.lastname: Taunk
authors.affiliation: Department of Pediatric Oncology, Memorial Sloan Kettering Cancer Center, New York.
authors.forename: Brian
authors.initials: B
authors.lastname: Kushner
authors.affiliation: Department of Neurology, Rehabilitation Service, Memorial Sloan Kettering Cancer Center, New York.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Ibanez
authors.affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York.
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Wolden
mesh_terms: D002675:Child, Preschool; D003131:Combined Modality Therapy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D008297:Male; D009220:Myositis / Q000209:etiology*; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy* / Q000601:surgery*; D009447:Neuroblastoma / Q000532:radiotherapy / Q000601:surgery*; D016634:Radiosurgery / Q000009:adverse effects*; D011878:Radiotherapy
keywords: SBRT; myositis; neuroblastoma; stereotactic body radiotherapy