title: [Preliminary study of clinical significance of decreased D(L)CO in patients with left ventricular heart failure].
abstract: OBJECTIVE
  This study aimed to investigate the feature of D(L)CO (Diffusion Lung Capacity for Carbon Monoxide) in CHF (left ventricular heart failure) patients, underlying pathophysiological mechanism and clinical significance.
  
  
  METHODS
  We retrospectively studied the D(L)CO, pulmonary ventilation function, cardiopulmonary exercise testing and related clinical information in severer HF patients.
  
  
  RESULTS
  Peak VO2 severely decreased to 34 ± 7 percentage of predicted(%pred) and anaerobic threshold to 48 ± 11%pred in all patients. D(L)CO moderately decreased to 63 ± 12%pred and there were 25 patients lower than 80%pred. FVC, FEV1, FEV1/FVC and TLC were 75 ± 14%pred, 71 ± 17%pred, 97 ± 11%pred, and 79 ± 13%pred, which indicated borderline or mild restrictive ventilatory dysfunction. The decrease of D(L)CO was more severe than those of TLC, FEV1 and FVC.
  
  
  CONCLUSIONS
  For patients with severe CHF, cardiopulmonary exercise function is extremely limited, D(L)CO generally moderately declines and ventilation function is merely mildly limited. D(L)CO is the parameter for cardiopulmonary coupling, reflecting limitation of the cardiovascular dysfunction while without ventilatory limit.
authors.forename: Xiao-yue
authors.initials: XY
authors.lastname: Tan
authors.forename: Xing-guo
authors.initials: XG
authors.lastname: Sun
authors.forename: Sheng-shou
authors.initials: SS
authors.lastname: Hu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.forename: Zhi-gao
authors.initials: ZG
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Ma
mesh_terms: D001784:Blood Gas Analysis; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*