title: Early Osseointegration Events on Neoss® ProActive and Bimodal Implants: A Comparison of Different Surfaces in an Animal Model.
abstract: BACKGROUND
  Cell interactions, adherence, and osseointegration at the bone-implant interface can be directly influenced by the surface properties of the titanium implant.
  
  
  OBJECTIVE
  To characterize osseointegration of Neoss® implants with conventional (control group) and hydrophilic (test group) surface treatments.
  
  
  METHODS
  Six Labrador dogs received Neoss implants with conventional and hydrophilic surfaces. The bone-implant interfaces were evaluated 1 and 4 weeks after implantation, and osseointegration was evaluated using histological, histomorphometric, fluorescence, and resonance frequency analyses. The surfaces were also subjected to topographic and hydrophilicity analyses.
  
  
  RESULTS
  The topographic analyses revealed increased surface roughness in the test group compared with the control group (surface area roughness 0.42 and 0.78 μm, respectively, for control and test group surfaces; p ≤ .05). The wettability values were higher in the test group (contact angles 67.2° and 27.2° for the control and test group surfaces, respectively; p ≤ .05). Implants in the test group also exhibited better stability, more bone-implant contact, and increased bone area compared with implants in the control group.
  
  
  CONCLUSIONS
  Neoss implants in the test group improved bone formation in the early stages of osseointegration compared with implants in the control group.
authors.affiliation: Faculty of Dentistry, University of São Paulo at Ribeirão Preto, Ribeirão Preto, Brazil.
authors.forename: Gustavo Augusto
authors.initials: GA
authors.lastname: Grossi-Oliveira
authors.affiliation: Faculty of Dentistry, University of São Paulo at Ribeirão Preto, Ribeirão Preto, Brazil.
authors.forename: Antonio Azoubel
authors.initials: AA
authors.lastname: Antunes
authors.affiliation: Department of Mechanical Engineering and Materials Science, Military Institute of Engineering, Rio de Janeiro, Brazil.
authors.forename: Carlos Nelson
authors.initials: CN
authors.lastname: Elias
authors.affiliation: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors.forename: Ann
authors.initials: A
authors.lastname: Wennerberg
authors.affiliation: Department of Oral & Maxillofacial Surgery, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Sennerby
authors.affiliation: Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Luiz Antonio
authors.initials: LA
authors.lastname: Salata
mesh_terms: D000818:Animals; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004285:Dogs; D057927:Hydrophobic and Hydrophilic Interactions; D020007:Implants, Experimental; D023421:Models, Animal; D016348:Osseointegration / Q000502:physiology*; D013499:Surface Properties
chemical_list: D015921:Dental Implants
keywords: animal model; bone‐implant interface; implant surface; surface properties; surface topography