title: Low-Grade Inflammation and Increased Arterial Stiffness in Chinese Youth and Adolescents with Newly-Diagnosed Type 2 Diabetes Mellitus.
abstract: OBJECTIVE
  To investigate the relationship between low-grade inflammation (LI) and increased arterial stiffness in Chinese youth and adolescents with newly-diagnosed type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  Ninety-eight subjects aged 10 to 24 years with newly-diagnosed T2DM were investigated for findings of general inflammation. Anthropometric measurements were taken. Data related to arterial stiffness [brachial artery distensibility (Branch D), augmentation index (AIx), carotid-femoral pulse wave velocity (CF-PWV)] were collected. The subjects were divided into a non-LI group (NLI, n=42) and a LI group (n=56) according to their high-sensitivity C-reactive protein (Hs-CRP) levels.
  
  
  RESULTS
  There were no significant differences in age and gender between the LI group and the NLI group. CF-PWV and AIx values of the LI group were higher than those of the NLI group (p<0.01), while Branch D values were lower in the LI group (p<0.01). Branch D, CF-PWV, and AIx values correlated significantly with Hs-CRP overall (r=-0.32, 0.34, 0.33, all p<0.01). Multivariate models revealed that in either group (LI or NLI), Hs-CRP, as a continuous variable, was an independent determinant of arterial stiffness parameters even after adjusting for other risk factors.
  
  
  CONCLUSIONS
  Newly-diagnosed T2DM youth and adolescents with LI present a more adverse cardiovascular disease risk profile and stiffer arteries. Hs-CRP levels correlated with arterial stiffness parameters and constituted an independent determinant of arterial stiffness.
authors.affiliation: Wuhan University Faculty of Medicine, Zhongnan Hospital, Clinic of Endocrinology, Wuhan, China Phone: 0086-27-67813107 E-mail: wdy2003win@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: You-Ping
authors.initials: YP
authors.lastname: Deng
authors.forename: Miao
authors.initials: M
authors.lastname: Yang
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Wu
authors.forename: Su-Xin
authors.initials: SX
authors.lastname: Sun
authors.forename: Jia-Zhong
authors.initials: JZ
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000453:epidemiology; D002648:Child; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000453:epidemiology; D008297:Male; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult