title: Poorly differentiated salivary gland carcinoma with prominent squamous metaplasia in a pregnant Wistar Hannover rat.
abstract: A subcutaneous pale brown-colored mass was observed macroscopically in the ventral neck of a 16-week-old Wistar rat on day 18 of gestation. The mass was well demarcated from the adjacent tissues with partial invasion into connective tissues. Necrosis and hemorrhage were evident throughout the mass. The mass comprised a diffuse sheet and a nest-like structure of epithelial cells with prominent squamous metaplasia. The neoplastic cells tested immunopositive for keratin, vimentin, glial fibrillary acidic protein and p63. A portion of the neoplastic cells exhibited a similar immunoreaction of prominin-1 to the ductal and acinar cells in normal submandibular and parotid glands. Collectively, the tumor was diagnosed as a poorly differentiated carcinoma derived from epithelial/myoepithelial lineages in the submandibular and/or parotid glands.
authors.affiliation: Laboratory of Pathology, Toxicology Division, The Institute of Environmental Toxicology, Uchimoriya-machi 4321, Joso-shi, Ibaraki 303-0043, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shimada
authors.forename: Toshinori
authors.initials: T
authors.lastname: Yoshida
authors.forename: Naofumi
authors.initials: N
authors.lastname: Takahashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Akema
authors.forename: Katsumi
authors.initials: K
authors.lastname: Soma
authors.forename: Aya
authors.initials: A
authors.lastname: Ohnuma-Koyama
authors.forename: Akira
authors.initials: A
authors.lastname: Sato
authors.forename: Maki
authors.initials: M
authors.lastname: Kuwahara
authors.forename: Takanori
authors.initials: T
authors.lastname: Harada
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D005260:Female; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000662:veterinary*; D051381:Rats; D017208:Rats, Wistar; D012468:Salivary Gland Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D012469:Salivary Glands / Q000473:pathology