title: The effect of adolescence and advanced maternal age on the incidence of complete and partial molar pregnancy.
abstract: OBJECTIVE
  To compare the age-specific incidence of complete (CM) and partial molar (PM) pregnancy in a large tertiary care center in the United States.
  
  
  METHODS
  Incidence rates of CM and PM per 10,000 live births were calculated using databases from Brigham and Women's Hospital, between 2000 and 2013. Age-specific rates were calculated for women younger than 20 years old (adolescents), 20-39 years old (average age), and 40 years and older (advanced maternal age). Pearson χ(2) test was used to evaluate potential differences among groups. Rate ratios (RR) and 95% confidence intervals (CI) were used to compare risk of molar pregnancy among average age women with that of adolescents and women of advanced age. Holm-Bonferonni adjustment was used to correct for multiple comparisons.
  
  
  RESULTS
  Between 2000 and 2013, there were 255 molar pregnancies (140 CM and 115 PM) and 105,942 live births, corresponding to a molar pregnancy rate of 24 per 10,000 live births (95% CI 21-27). Rates of CM and PM were 13 (95% CI 11-16) and 11 (95% CI 9-14) per 10,000 live births respectively. The incidence of CM differed significantly among maternal age groups (p<0.001). Compared to average age women, adolescents were 7.0 times as likely to develop CM (95% CI 3.6-8.9, p<0.001), and women with advanced maternal age were nearly twice as likely (1.9, 95% CI 1.8-4.7, p=0.002). The rate of PM did not vary significantly among age groups (p=0.26).
  
  
  CONCLUSIONS
  Adolescence and advanced maternal age were associated with increased risk of complete mole, but not partial mole.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, USA; Vincent Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Boston, USA; Department of Obstetrics, Gynecology & Reproductive Biology, Harvard Medical School Boston, MA, USA.
authors.forename: Allison A
authors.initials: AA
authors.lastname: Gockley
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, USA; Vincent Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Boston, USA; Department of Obstetrics, Gynecology & Reproductive Biology, Harvard Medical School Boston, MA, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Melamed
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, USA; Vincent Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Boston, USA; Department of Obstetrics, Gynecology & Reproductive Biology, Harvard Medical School Boston, MA, USA.
authors.forename: Naima T
authors.initials: NT
authors.lastname: Joseph
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, USA; Vincent Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Boston, USA; Department of Obstetrics, Gynecology & Reproductive Biology, Harvard Medical School Boston, MA, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Clapp
authors.affiliation: Department of Obstetrics, Paulista School of Medicine, UNIFESP - São Paulo Federal University, São Paulo, SP, Brazil; Trophoblastic Disease Center of São Paulo Hospital, Paulista School of Medicine, UNIFESP - São Paulo Federal University, São Paulo, SP, Brazil; New England Trophoblastic Disease Center, Donald P. Goldstein M.D., Trophoblastic Tumor Registry, Boston, USA.
authors.forename: Sue Yazaki
authors.initials: SY
authors.lastname: Sun
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, USA; Gynecologic Oncology Program, Susan F. Smith Center for Women's Cancers, Dana Farber Cancer Institute/Harvard Cancer Center, Boston, USA; New England Trophoblastic Disease Center, Donald P. Goldstein M.D., Trophoblastic Tumor Registry, Boston, USA.
authors.forename: Donald P
authors.initials: DP
authors.lastname: Goldstein
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, USA; Gynecologic Oncology Program, Susan F. Smith Center for Women's Cancers, Dana Farber Cancer Institute/Harvard Cancer Center, Boston, USA; New England Trophoblastic Disease Center, Donald P. Goldstein M.D., Trophoblastic Tumor Registry, Boston, USA.
authors.forename: Neil S
authors.initials: NS
authors.lastname: Horowitz
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, USA; Gynecologic Oncology Program, Susan F. Smith Center for Women's Cancers, Dana Farber Cancer Institute/Harvard Cancer Center, Boston, USA; New England Trophoblastic Disease Center, Donald P. Goldstein M.D., Trophoblastic Tumor Registry, Boston, USA. Electronic address: rberkowitz@partners.org.
authors.forename: Ross S
authors.initials: RS
authors.lastname: Berkowitz
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000145:classification* / Q000453:epidemiology*; D015994:Incidence; D008423:Maternal Age; D011247:Pregnancy; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Complete mole; Maternal age; Partial mole