title: The Role of Surgery in Local Recurrences after Radical Cystectomy for Bladder Cancer.
abstract: BACKGROUND
  Local recurrence (LR) after radical cystectomy (RC) for bladder cancer has a bad prognosis. Treatment options include chemotherapy, radiation therapy and surgical excision, but few data is available on the advantages of surgery for these patients.
  
  
  METHODS
  We evaluated our series of 8 selected patients who underwent surgery for locally recurrent bladder cancer after RC.
  
  
  RESULTS
  The median time to recurrence after cystectomy was 20.8 months. The complications rate and severity were not negligible. Pathology report confirmed urothelial carcinoma with negative margins in all patients. After LR treatment, 4 patients recurred locally for a second time and 3 developed distant metastasis. They all died after a median follow-up of 10.4 months. One patient remained disease free after 14 months.
  
  
  CONCLUSIONS
  The prognosis of patients with LR is poor regardless of surgical treatment and reflects the aggressive biological nature of urothelial tumors.
authors.affiliation: Urology Department, Hospital Clx00ED;nic de Barcelona, Barcelona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Vilaseca
authors.forename: Jorge
authors.initials: J
authors.lastname: Huguet
authors.forename: Meritxell
authors.initials: M
authors.lastname: Pérez
authors.forename: Daniel
authors.initials: D
authors.lastname: Camacho
authors.forename: Eduardo
authors.initials: E
authors.lastname: García-Cruz
authors.forename: Maria
authors.initials: M
authors.lastname: José Ribal
authors.forename: Antonio
authors.initials: A
authors.lastname: Alcaraz
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D015653:Cystectomy / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D018450:Disease Progression; D018572:Disease-Free Survival; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*