title: Decreased peroxisome proliferator-activated receptor γ level and signalling in sebaceous glands of patients with acne vulgaris.
abstract: Little is known about the altered lipid metabolism-related transcriptional events occuring in sebaceous glands of patients with acne vulgaris. Peroxisome proliferator-activated receptor (PPAR)γ, a lipid-activated transcription factor, is implicated in differentiation and lipid metabolism of sebocytes. We have observed that PPARγ and its target genes, ADRP (adipose differentiation related protein) and PGAR (PPARγ angioprotein related protein) are expressed at lower levels in sebocytes from patients with acne than in those from healthy controls (HCs) Furthermore, endogenous PPARγ activator lipids such as arachidonic acid-derived keto-metabolites (e.g. 5KETE, 12KETE) are increased in acne-involved and nonacne-involved skin of patients with acne, compared with skin from healthy individuals. Our findings highlight the possible anti-inflammatory role of endogenous ligand-activated PPARγ signaling in human sebocyte biology, and suggest that modulating PPARγ- expression and thereby signaling might be a promising strategy for the clinical management of acne vulgaris.
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.|Department of Dermatology, Semmelweis Ignác Hospital and University Teaching Hospital in Miskolc, Miskolc, Hungary.|Department of Dermatology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Dozsa
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Mihaly
authors.affiliation: Department of Pathology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: B
authors.initials: B
authors.lastname: Dezso
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Csizmadia
authors.affiliation: Department of Dermatology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: T
authors.initials: T
authors.lastname: Keresztessy
authors.affiliation: Department of Dermatology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Marko
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: R
authors.initials: R
authors.lastname: Rühl
authors.affiliation: Department of Dermatology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Remenyik
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.|DE-MTA 'Lendület' Immunogenomics Research Group, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Nagy
mesh_terms: D000152:Acne Vulgaris / Q000378:metabolism*; D000328:Adult; D000704:Analysis of Variance; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins / Q000378:metabolism; D016022:Case-Control Studies; D015777:Eicosanoids / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D047495:PPAR gamma / Q000378:metabolism*; D000070780:Perilipin-2 / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012627:Sebaceous Glands / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C474772:ANGPTL4 protein, human; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins; D015777:Eicosanoids; C000602982:PLIN2 protein, human; D047495:PPAR gamma; D000070780:Perilipin-2; D012333:RNA, Messenger