title: Clinicopathologic features and treatment of breast metastasis from nasopharyngeal carcinoma: A report of two cases and literature review.
abstract: Breast metastasis is a rare pattern of distant metastasis from nasopharyngeal carcinoma (NPC) following curative treatment. The present study reported two patients with breast metastasis from NPC and reviewed four such patients reported in the literature, including the analysis of clinical profiles, pathological diagnoses, treatment strategies and outcomes. The breast is a potential metastatic site for patients with NPC following curative treatment; however, thus far, only metachronous breast metastasis has been reported. Infection with Epstein-Barr virus (EBV) was identified in the breast metastasis sites of the two patients investigated in the current study usingin situhybridization for EBV-encoded small RNAs. Patients with breast metastases from NPC consistently and simultaneously develop metastases in other sites. In addition, the two current patients had poor prognoses. Therefore, chemotherapy was the primary treatment strategy administered. A solitary breast metastasis was identified in the male patient. At the most recent follow-up 10 years subsequent to undergoing a Halsted mastectomy, the patient remained alive, however the patient is now lost to follow-up. This case indicates that patients exhibiting NPC with a solitary breast metastasis may still gain long-term survival by undergoing radical mastectomy; therefore, radical mastectomy should be considered in such patients.
authors.affiliation: Department of Radiotherapy, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China; State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P.R. China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Radiotherapy, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China; State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P.R. China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of Oncology, Tengzhou Center People's Hospital, Tengzhou, Shandong 277500, P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Xing
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P.R. China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China; Department of Ultrasonography, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhen
authors.affiliation: Institute of Molecular Medicine, Medical School of Shenzhen University, Shenzhen University, Shenzhen, Guangdong 518000, P.R. China.
authors.forename: Shaoxiang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Radiotherapy, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China; State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P.R. China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Huanxin
authors.initials: H
authors.lastname: Lin
keywords: breast metastasis; epstein-barr virus; nasopharyngeal carcinoma