title: Serum acute phase proteins in Dirofilaria immitis and Wolbachia seropositive cats.
abstract: Objectives The aim of this study was to characterise the response of acute phase proteins (APPs) in cats seropositive for Dirofilaria immitis and to its endosymbiont bacterium Wolbachia. Methods The APPs serum amyloid A (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) were measured in 25 seropositive cats and in 16 healthy seronegative cats. Results SAA and Cp concentrations were significantly higher in animals with D immitis seropositivity that exhibited clinical signs related to the disease, and Hp was elevated in all D immitis-seropositive animals. There was no significant correlation between APPs and D immitis or Wolbachia species antibody titres. Conclusions and relevance An association between feline seropositivity to D immitis and APP response was demonstrated. Increases in serum SAA and Cp concentrations were related to D immitis-associated clinical signs, whereas Hp increased in all seropositive animals.
authors.affiliation: 1 Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.|2 Animal and Veterinary Research Centre (CECAV), University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Silvestre-Ferreira
authors.affiliation: 1 Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
authors.forename: Lisete
authors.initials: L
authors.lastname: Vieira
authors.affiliation: 2 Animal and Veterinary Research Centre (CECAV), University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.|3 Department of Veterinary Medicine, Vasco da Gama University School Coimbra, Coimbra, Portugal.|4 Baixo Vouga Veterinary Hospital, Segadães-Águeda, Portugal.
authors.forename: Hugo
authors.initials: H
authors.lastname: Vilhena
authors.affiliation: 5 Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, Espinardo, Murcia, Spain.
authors.forename: Jose J
authors.initials: JJ
authors.lastname: Cerón
authors.affiliation: 5 Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, Espinardo, Murcia, Spain.|6 Department of Animal Medicine and Surgery, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: Asta
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.affiliation: 7 Research Institute of Biomedical and Health Sciences (IUIBS), Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Arucas, Las Palmas, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Montoya-Alonso
authors.affiliation: 7 Research Institute of Biomedical and Health Sciences (IUIBS), Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Arucas, Las Palmas, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Carretón
authors.affiliation: 6 Department of Animal Medicine and Surgery, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Pastor
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D002371:Cat Diseases / Q000097:blood / Q000175:diagnosis*; D002415:Cats; D004183:Dirofilaria immitis / Q000276:immunology*; D004184:Dirofilariasis / Q000097:blood / Q000175:diagnosis*; D005260:Female; D008297:Male; D011237:Predictive Value of Tests; D012698:Serologic Tests / Q000662:veterinary; D020577:Wolbachia / Q000276:immunology*
chemical_list: D000209:Acute-Phase Proteins; D000907:Antibodies, Bacterial