title: Mohangic Acids A-E, p-Aminoacetophenonic Acids from a Marine-Mudflat-Derived Streptomyces sp.
abstract: Mohangic acids A-E (1-5) were isolated from a marine Streptomyces sp. collected from a mudflat in Buan, Republic of Korea. Comprehensive spectroscopic analysis revealed that the mohangic acids are new members of the p-aminoacetophenonic acid class. The relative and absolute configurations of the mohangic acids were determined by J-based configuration analysis and by the application of bidentate chiral NMR solvents followed by (13)C NMR analysis, chemical derivatization, and circular dichroism spectroscopy. Mohangic acid E (5), which is the first glycosylated compound in the p-aminoacetophenonic acid family, displayed significant quinone reductase induction activity.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Republic of Korea.
authors.forename: Munhyung
authors.initials: M
authors.lastname: Bae
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Republic of Korea.
authors.forename: Kyuho
authors.initials: K
authors.lastname: Moon
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Republic of Korea.
authors.forename: Jihye
authors.initials: J
authors.lastname: Kim
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Republic of Korea.
authors.forename: Hyen Joo
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Republic of Korea.
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Republic of Korea.
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Republic of Korea.
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
mesh_terms: D000098:Acetophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000465:Algorithms; D004354:Drug Screening Assays, Antitumor; D007630:Kenya; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011808:Quinone Reductases / Q000378:metabolism; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000098:Acetophenones; C000608904:mohangic acid A; D011808:Quinone Reductases