title: The predictive value of soluble endothelial selectin plasma levels in children with acute lung injury.
abstract: The study aimed to evaluate the value of soluble endothelial selectin (sE-selectin) plasma level measurement in predicting acute lung injury (ALI) outcome in children.
  
  
  METHODS
  The study was a prospective, controlled study that involved 50 children with ALI and 50 healthy children as a control. Soluble endothelial selectin and C-reactive protein plasma levels were measured at days 1 and 7 of development of ALI for the patient group and done only once for the control group.
  
  
  RESULTS
  Plasma sE-selectin was significantly higher in the patients than the control group (P = .001). Mortality reached 32% of children with ALI. The deceased subgroup had significantly higher plasma sE-selectin levels both at days 1 and 7 than the survived (P = .02 and P < .001 respectively). There was positive correlation between plasma sE-selectin at day 7 with durations of both pediatric intensive care unit and mechanical ventilation. Levels of sE-selectin at days 1 and 7 had significant positive correlation with C-reactive protein level and ALI severity. Soluble endothelial selectin plasma levels of 302 ng/mL at day 7 were the best cutoff value to predict ALI-related deaths.
  
  
  CONCLUSIONS
  Plasma sE-selectin level served as a good predictor biomarker for both mechanical ventilation duration and the mortality risk in children with ALI.
authors.affiliation: Pediatric Department, Faculty of Medicine, Medical Complex, Tanta University, Tanta, Egypt. Electronic address: mbelrem@hotmail.com.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Al-Biltagi
authors.affiliation: Pediatric Department, Faculty of Medicine, Medical Complex, Tanta University, Tanta, Egypt.
authors.forename: Ahmed Abd ElBasset
authors.initials: AA
authors.lastname: Abo-Elezz
authors.affiliation: Pediatric Department, Faculty of Medicine, Medical Complex, Tanta University, Tanta, Egypt.
authors.forename: Rasha Mohamed Gamal
authors.initials: RM
authors.lastname: Elshafiey
authors.affiliation: Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
authors.forename: Ghada Abudelmomen
authors.initials: GA
authors.lastname: Suliman
authors.affiliation: Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
authors.forename: Maaly Mohamed
authors.initials: MM
authors.lastname: Mabrouk
authors.affiliation: Pediatric Department, Faculty of Medicine, Medical Complex, Tanta University, Tanta, Egypt.
authors.forename: Hossam Ahmed
authors.initials: HA
authors.lastname: Mourad
mesh_terms: D055371:Acute Lung Injury / Q000097:blood* / Q000401:mortality / Q000503:physiopathology; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D015278:Intensive Care Units, Pediatric; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012121:Respiration, Artificial; D019087:Selectins / Q000097:blood*
chemical_list: D015415:Biomarkers; D019087:Selectins; D002097:C-Reactive Protein
keywords: Acute lung injury; Acute respiratory distress syndrome; C-reactive protein; Children; Soluble endothelial selectin; sE-selectin