title: [Efficacy of volume-targeted ventilation for the treatment of neonatal respiratory distress syndrome].
abstract: OBJECTIVE
  To investigate the efficacy of volume-targeted ventilation (VTV) for the treatment of neonatal respiratory distress syndrome (NRDS).
  
  
  METHODS
  Fifty-two neonates with NRDS between August 2013 and August 2015 were randomly divided into two groups: VTV and pressure-controlled ventilation (PCV) (n=26 each ). A/C+Vc+ ventilation model was applied in the VTV group, and A/C+PCV ventilation model was applied in the PCV group. Arterial blood gas analysis was performed at 6, 24, and 48 hours after ventilation. The following parameters were observed: time of invasive ventilation, duration of oxygen therapy, mortality, and the incidence rates of hypocapnia, pneumothorax, ventilator-associated pneumonia (VAP), grade III-IV periventricular-intraventricular hemorrhage (PVH-IVH), periventricular leukomalacia (PVL), bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP).
  
  
  RESULTS
  Compared with the PCV group, the VTV group had a significantly shorter time of invasive ventilation (P<0.05) and significantly lower incidence rates of hypocapnia, VAP, and PVL (P<0.05); however, there were no significant differences in the duration of oxygen therapy, mortality, and incidence rates of pneumothorax, grade III-IV PVH-IVH, BPD, and ROP.
  
  
  CONCLUSIONS
  VTV has a better efficacy than PCV in the treatment of NRDS, and is worthy of clinical promotion and application.
authors.affiliation: Pediatric Intensive Care Unit, Jiangmen Central Hospital, Jiangmen, Guangdong 529030, China. chenzhou748190@163.com.
authors.forename: Chen-Zhou
authors.initials: CZ
authors.lastname: Liu
authors.forename: Bi-Yin
authors.initials: BY
authors.lastname: Huang
authors.forename: Bao-Ying
authors.initials: BY
authors.lastname: Tan
authors.forename: Hao-Feng
authors.initials: HF
authors.lastname: Guan
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Xu
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Guo
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*