title: Salvianolic acid B ameliorates CNS autoimmunity by suppressing Th1 responses.
abstract: Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), is a Th1 and Th17 cell-mediated CNS autoimmune disease. Therefore, immune regulation is a key target for therapy. Salvianolic acid B (Sal B) is a major water-soluble bioactive component of the famous traditional Chinese medicine Salvia miltiorrhiza, which is notable for its anti-oxidative and anti-inflammatory effects. Thus Sal B, by impairing Th1 or Th17 responses in EAE/MS, might ameliorate the crippling symptoms. Here we show that the intraperitoneal administration of 30mg/kg Sal B daily for 14 days after the onset of MOG-induced EAE in mice effectively reduced its severity. Additionally, Sal B treatment downgraded the infiltration of inflammatory cells, limited astrogliosis and blocked Th1 responses other than that of Th17. These results indicated that Sal B may serve as an effective therapeutic agent for MS/EAE by inhibiting Th1 cell responses.
authors.affiliation: Department of Neurology, First Hospital, Jilin University, Changchun 130021, Jilin Province, China; Department of Neurology, Second Hospital, Jilin University, Changchun 130041, Jilin Province, China. Electronic address: 83328699@qq.com.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Department of Neurology, First Hospital, Jilin University, Changchun 130021, Jilin Province, China. Electronic address: madihui@263.net.
authors.forename: Dihui
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, 300052 Tianjin, China. Electronic address: 304165920@qq.com.
authors.forename: Ye
authors.initials: Y
authors.lastname: Gong
authors.affiliation: Department of Neurology, Second Hospital, Jilin University, Changchun 130041, Jilin Province, China. Electronic address: ytm_396@163.com.
authors.forename: Tingmin
authors.initials: T
authors.lastname: Yu
authors.affiliation: Department of Neurology, Second Hospital, Jilin University, Changchun 130041, Jilin Province, China. Electronic address: yaogang0431@163.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Yao
mesh_terms: D000818:Animals; D015551:Autoimmunity; D001572:Benzofurans / Q000494:pharmacology* / Q000627:therapeutic use; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D013116:Spinal Cord / Q000187:drug effects* / Q000276:immunology; D018417:Th1 Cells / Q000187:drug effects* / Q000276:immunology; D053630:Depsides
chemical_list: D001572:Benzofurans; D018696:Neuroprotective Agents; C076944:salvianolic acid B; D053630:Depsides
keywords: Experimental autoimmune encephalomyelitis; Multiple sclerosis; Salvia miltiorrhiza; Salvianolic acid B