title: L1 cell adhesion molecule as a therapeutic target in cancer.
abstract: L1 cell adhesion molecule (L1CAM) is the prototype member of the L1-family of closely related neural adhesion molecules. L1CAM is differentially expressed in the normal nervous system as well as pathological tissues and displays a wide range of biological activities. In human malignancies, L1CAM plays a vital role in tumor growth, invasion and metastasis. Recently, increasing evidence has suggested that L1CAM exerts a variety of functions at different steps of tumor progression through a series of signaling pathways. In addition, L1CAM has been identified as a promising target for cancer therapy by using synthetic and natural inhibitors. In this review, we provide an up-to-date overview of the role of L1CAM involved in cancers and the rationale for L1CAM as a novel molecular target for cancer therapy.
authors.affiliation: a Department of Pancreatic Surgery, Huashan Hospital , Fudan University , Shanghai , China.
authors.forename: Xinzhe
authors.initials: X
authors.lastname: Yu
authors.affiliation: a Department of Pancreatic Surgery, Huashan Hospital , Fudan University , Shanghai , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.affiliation: a Department of Pancreatic Surgery, Huashan Hospital , Fudan University , Shanghai , China.
authors.forename: De-Liang
authors.initials: DL
authors.lastname: Fu
authors.affiliation: a Department of Pancreatic Surgery, Huashan Hospital , Fudan University , Shanghai , China.
authors.forename: Chen
authors.initials: C
authors.lastname: Jin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D018450:Disease Progression; D006801:Humans; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D039842:Neural Cell Adhesion Molecule L1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D039842:Neural Cell Adhesion Molecule L1
keywords: L1 cell adhesion molecule; cancer therapy; cell migration; prognostic marker; signal pathway