title: Do affective or dissociative symptoms mediate the association between childhood sexual trauma and transition to psychosis in an ultra-high risk cohort?
abstract: We have previously reported an association between childhood sexual trauma and transition to psychosis in an Ultra High Risk (UHR) population. We aimed to investigate if this association was mediated by affective or dissociative symptoms. Data were from a large UHR for psychosis cohort study. None of the potential mediators (depression, anxiety, dissociation, mood swings and mania, assessed by the HAM-D, HAM-A and the CAARMS symptom scales) significantly mediated the total association between sexual abuse scores and transition. At the point of transition, the mechanistic pathway from sexual trauma to psychosis does not appear to operate through affective symptoms.
authors.affiliation: Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, UK. Electronic address: andrew.d.thompson@warwick.ac.uk.
authors.forename: Andrew
authors.initials: A
authors.lastname: Thompson
authors.affiliation: Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, UK.
authors.forename: Steven
authors.initials: S
authors.lastname: Marwaha
authors.affiliation: Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Melbourne, Australia.
authors.forename: Barnaby
authors.initials: B
authors.lastname: Nelson
authors.affiliation: Department of Psychology, University of Birmingham, UK.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Wood
authors.affiliation: Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Melbourne, Australia.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: McGorry
authors.affiliation: Institute of Brain and Behaviour, University of Manchester, UK.
authors.forename: Alison R
authors.initials: AR
authors.lastname: Yung
authors.affiliation: Telethon Kids Institute, University of Western Australia, Australia.
authors.forename: Ashleigh
authors.initials: A
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms / Q000523:psychology*; D001007:Anxiety / Q000523:psychology; D001714:Bipolar Disorder / Q000523:psychology; D002648:Child; D002650:Child Abuse, Sexual / Q000523:psychology*; D015331:Cohort Studies; D003863:Depression / Q000523:psychology; D004213:Dissociative Disorders / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000523:psychology; D011618:Psychotic Disorders / Q000523:psychology*; D012306:Risk; D055815:Young Adult
keywords: Affective symptoms; Cohort; Mediation; Psychotic disorders; Ultra high risk