title: p53 as guardian of the mitochondrial genome.
abstract: Participating in the repair of nuclear DNA is one mechanism by which p53 suppresses tumorigenesis, but there is growing evidence that p53 also helps maintain the mitochondrial genome through its translocation into mitochondria and interactions with mtDNA repair proteins. Because of the susceptibility of mtDNA to oxidative damage and replication errors, it is vital to protect mtDNA genomic stability to preserve health and fitness. Here, we focus on reviewing the evidence for the involvement of p53 in maintaining the integrity of mtDNA through its activities in both the nucleus and the mitochondria.
authors.affiliation: Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Park
authors.affiliation: Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhuang
authors.affiliation: Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Hwang
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology / Q000378:metabolism; D004260:DNA Repair; D004272:DNA, Mitochondrial / Q000378:metabolism; D054629:Genome, Mitochondrial; D042822:Genomic Instability; D006801:Humans; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D008954:Models, Biological; D021381:Protein Transport; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D004272:DNA, Mitochondrial; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
keywords: DNA repair; mitochondria; mtDNA; p53; reactive oxygen species; translocation