title: The Values and Limitations of FDG-PET/CT for Diagnosis of Hibernoma.
abstract: Hibernoma is a rare benign lipogenic tumor of brown fat that develops in a wide variety of locations. Although the features of hibernoma demonstrated by MRI resemble those of liposarcoma, recent FDG-PET/CT studies have documented higher radiotracer uptake than liposarcoma, suggesting that FDG/PET/CT is useful for differentiating hibernoma from liposarcoma. Here we report two cases of hibernoma that showed relatively lower SUVs than those reported previously, lying within the range for liposarcoma. Our findings emphasize that hibernoma needs to be included in the differential diagnosis of any fat-containing tumor showing intense accumulation by FDG-PET/CT. Although it is unlikely that such a rare condition could be reasonably diagnosed on the basis of MRI and FDG-PET/CT alone due to possible SUV overlap between hibernoma and liposarcoma, it is important to recognize this extremely rare lipogenic tumor for accurate diagnosis and appropriate management.
authors.affiliation: Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan; Department of Orthopaedic Surgery, Korea University Hospital, Seoul 02841, Republic of Korea.
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Ogura
authors.affiliation: Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Fujiwara
authors.affiliation: Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Akihito
authors.initials: A
authors.lastname: Nagano
authors.affiliation: Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Numoto
authors.affiliation: Department of Nuclear Medicine, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Terauchi
authors.affiliation: Department of Pathology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kawai