title: Cracking the epitranscriptome.
abstract: Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made in recent years. The discussed aspects are also very relevant for a wide range of additional modifications on mRNA collectively coined the epitranscriptome.
authors.affiliation: Department of Molecular Genetics, Weizmann Institute, Rehovot 76100, Israel.
authors.forename: Schraga
authors.initials: S
authors.lastname: Schwartz
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D044127:Epigenesis, Genetic; D006801:Humans; D008745:Methylation; D051379:Mice; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D059467:Transcriptome
chemical_list: D012333:RNA, Messenger; C010223:N-methyladenosine; D000241:Adenosine
keywords: N6-methyladenosine; epitranscriptome; review