title: Central regions of keloids are severely ischaemic.
abstract: We classified scars as keloids, hypertrophic scars and mature scars, and then examined the scars for differences in central and marginal vascularization. We found significant differences in localized hypoxia-induced factor-1α (HIF-1α) expression and vascular density in keloids, but no localized differences in hypertrophic or mature scars. The central areas of keloids exhibited higher HIF-1α expression and lower vascular density than marginal areas, suggesting that the former are severely ischaemic.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Osaka Medical College, Takatsuki, Osaka, Japan. Electronic address: ryo_0623_ma@yahoo.co.jp.
authors.forename: Ryoma
authors.initials: R
authors.lastname: Touchi
authors.affiliation: Department of Plastic and Reconstructive Surgery, Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Ueda
authors.affiliation: Department of Plastic Surgery, Takatsuki General Hospital, Takatsuki, Osaka, Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Kurokawa
authors.affiliation: Department of Pathology, Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Motomu
authors.initials: M
authors.lastname: Tsuji
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D017439:Cicatrix, Hypertrophic / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007223:Infant; D007511:Ischemia / Q000473:pathology*; D007627:Keloid / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012867:Skin / Q000098:blood supply* / Q000473:pathology; D055815:Young Adult
keywords: Hypoxia-induced factor 1α; Ischaemia; Keloid; Vascular endothelial growth factor