title: Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice.
abstract: Korean pine nut oil (PNO) has been reported to influence weight gain and lipid metabolism. We examined whether PNO replacement in a high-fat diet (HFD) can ameliorate HFD-induced hepatic steatosis. Five-week-old male C57BL mice were fed control diets containing 10% of the energy from fat from PNO or soybean oil (SBO) (PC, SC) or HFDs with 45% of the energy from fat, with 10% from PNO or SBO and 35% from lard (PHFD, SHFD), for 12 weeks. Body weight gain and amount of white adipose tissue were lower in PHFD (10% and 18% lower, respectively) compared with SHFD. Hepatic triacylglycerol (TG) level was significantly lower in PHFD than the SHFD (26% lower). PNO consumption upregulated hepatic ACADL mRNA levels. The hepatic PPARG mRNA level was lower in the PC than in the SC. Expression of the sirtuin (SIRT) 3 protein in white adipose tissue was down-regulated in the SHFD and restored in the PHFD to the level in the lean control mice. SIRT 3 was reported to be upregulated under conditions of caloric restriction (CR) and plays a role in regulating mitochondrial function. PNO consumption resulted in lower body fat and hepatic TG accumulation in HFD-induced obesity, which seemed to be associated with the CR-mimetic response.
authors.affiliation: Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 151-742, Korea. naroo24@snu.ac.kr.
authors.forename: Soyoung
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 151-742, Korea. shanhui1@snu.ac.kr.
authors.forename: Sunhye
authors.initials: S
authors.lastname: Shin
authors.affiliation: Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 151-742, Korea. mee1132@snu.ac.kr.
authors.forename: Yeseo
authors.initials: Y
authors.lastname: Lim
authors.affiliation: College of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, Korea. water21@snu.ac.kr.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Shin
authors.affiliation: College of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, Korea. snumouse@snu.ac.kr.|Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Korea. snumouse@snu.ac.kr.|Bio-MAX Institute, Seoul National University, Seoul 151-742, Korea. snumouse@snu.ac.kr.
authors.forename: Je Kyung
authors.initials: JK
authors.lastname: Seong
authors.affiliation: Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 151-742, Korea. snhan@snu.ac.kr.|Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Korea. snhan@snu.ac.kr.
authors.forename: Sung Nim
authors.initials: SN
authors.lastname: Han
mesh_terms: D044942:Acyl-CoA Dehydrogenase, Long-Chain / Q000235:genetics; D052436:Adipose Tissue, White / Q000187:drug effects; D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects; D005234:Fatty Liver / Q000178:diet therapy / Q000209:etiology / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009754:Nuts / Q000737:chemistry; D009765:Obesity / Q000178:diet therapy / Q000209:etiology / Q000378:metabolism*; D047495:PPAR gamma / Q000235:genetics; D028223:Pinus / Q000737:chemistry*; D010938:Plant Oils / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D056566:Sirtuin 3 / Q000378:metabolism; D013024:Soybean Oil / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
chemical_list: D004041:Dietary Fats; D047495:PPAR gamma; D010938:Plant Oils; D012333:RNA, Messenger; C525046:Sirt3 protein, mouse; D014280:Triglycerides; D013024:Soybean Oil; D044942:Acyl-CoA Dehydrogenase, Long-Chain; D056566:Sirtuin 3; C029310:lard
keywords: SIRT3; hepatic steatosis; high-fat diet; obesity; pine nut oil