title: Palladium-Catalyzed C-H Functionalization of Aromatic Oximes: A Strategy for the Synthesis of Isoquinolines.
abstract: An efficient strategy for synthesis of isoquinolines via Pd(II)-catalyzed cyclization reaction of oximes with vinyl azides or homocoupling of oximes is reported. Oximes could serve as a directing group and an internal oxidant in the transformation. This reaction features good functional group tolerance and provides a useful protocol for the synthesis of different kinds of isoquinolines under mild conditions. Some control experiments and (15)N isotope labeling experiments were conducted for the mechanistic research.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, People's Republic of China.
authors.forename: Zhongzhi
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, People's Republic of China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Tang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, People's Republic of China.
authors.forename: Xianwei
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, People's Republic of China.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, People's Republic of China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Deng
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, People's Republic of China.
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang