title: [Seroprevalence of hepatitis B and C viruses, HIV-1/2 and syphilis among blood donors in the Yaoundé Central Hospital in the centre region of Cameroon].
abstract: OBJECTIVE
  Prevention of blood transfusion-transmitted infections includes blood donor screening and effective infectious markers screening for donated blood. This study had two main objectives: to determine seroprevalence of HBV, HCV, HIV and syphilis in blood donors of the Yaoundé Central Hospital and to study sociodemographic factors of blood donors.
  
  
  METHODS
  A retrospective study of consecutive blood donors' records from January to December 2013 was conducted. Seroprevalence of hepatitis B, hepatitis C, human immunodeficiency viruses and syphilis were determined in 9024 whole blood donations collected in the Yaoundé Central Hospital in the centre region, Cameroon using Elisa kits.
  
  
  RESULTS
  Mean age of donors was 28 years. The male to female ratio was 14.8. Most of blood donors were replacement donors (97.2%) and first-time donors (76.8%). Up to 19.3% of the donors tested positive for at least one infectious agent, in which 0.1% presented a positive test for three viruses (HIV, HCV and HBV). The overall seroprevalence in blood donors was 12.6% for HBsAg, 3.2% for hepatitis C antibody, 3.3% for HIV-1/2 antibodies and 0.2% for syphilis. The prevalence of HBsAg was significantly higher in men (P=0.001), among first-time donors (P=0.003), in blood group A (P=0.01) and those with the rhesus positive blood (P=0.01). The prevalence of anti-HCV was significantly higher among first-time donors (P=0.05). The prevalence of anti-HIV was significantly higher in first-time donors (3.7% vs 2.2%, P=0.02).
  
  
  CONCLUSIONS
  First-time blood donors and replacement donors are the two types of donors in Cameroon. Replacement donors are considered as having a major risk of transmission of infections to recipients. The seroprevalence of HIV, HBV, HCV, and syphilis among these donors is high and reflects how much these agents are present in Cameroon. Effective infectious markers screening and organization of blood donors into an association of volunteer's donors are necessary to secure blood transfusion in Cameroon.
authors.affiliation: Faculté de médecine et des sciences biomédicales, université de Yaoundé 1, centre hospitalier et universitaire de Yaoundé, Yaoundé, Cameroun. Electronic address: ankouaneandoulo@yahoo.com.
authors.forename: F
authors.initials: F
authors.lastname: Ankouane
authors.affiliation: Faculté de médecine et des sciences pharmaceutiques, université de Douala, hôpital central de Yaoundé, Yaoundé, Cameroun.
authors.forename: D
authors.initials: D
authors.lastname: Noah Noah
authors.affiliation: Hôpital de district de la cité des Palmiers, Douala-Bassa, Cameroun.
authors.forename: M M
authors.initials: MM
authors.lastname: Atangana
authors.affiliation: Laboratoire d'hématologie du CIRCB, Yaoundé, Cameroun.
authors.forename: R
authors.initials: R
authors.lastname: Kamgaing Simo
authors.affiliation: Faculté de médecine et des sciences biomédicales, université de Yaoundé 1, centre hospitalier et universitaire de Yaoundé, Yaoundé, Cameroun.
authors.forename: P R
authors.initials: PR
authors.lastname: Guekam
authors.affiliation: Faculté de médecine et des sciences biomédicales, université de Yaoundé 1, hôpital central de Yaoundé, Yaoundé, Cameroun.
authors.forename: M
authors.initials: M
authors.lastname: Biwolé Sida
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001782:Blood Donors; D058731:Blood Safety; D002163:Cameroon / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D015528:HIV Seroprevalence; D015497:HIV-1 / Q000276:immunology; D015498:HIV-2 / Q000276:immunology; D006509:Hepatitis B / Q000453:epidemiology*; D006526:Hepatitis C / Q000453:epidemiology*; D006786:Hospitals, Urban / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D013587:Syphilis / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral
keywords: Blood donors; Blood transfusion; Cameroon; Cameroun; Donneurs de sang; HIV; Hepatitis B virus; Hepatitis C virus; Prevalence; Prévalence; Syphilis; Transfusion sanguine; VIH; Virus de l’hépatite B; Virus de l’hépatite C