title: Association Between a Glucokinase Regulator Genetic Variant and Metabolic Syndrome in Taiwanese Adolescents.
abstract: OBJECTIVE
  Variants of the glucokinase regulator (GCKR) gene are associated with metabolic syndrome (MetS). The present study explored the association between a common variant of this gene and MetS and its related traits in Taiwanese adolescents.
  
  
  METHODS
  The frequency of MetS and its features were compared between subjects (n = 962; 468 male, 494 female) with different genotypes or alleles of the GCKR rs780094 single-nucleotide polymorphism. Logistic regression analysis was carried out to explore the interdependence of MetS and metabolic traits.
  
  
  RESULTS
  Low high-density lipoprotein cholesterol (HDL-C) levels and MetS were more prevalent in subjects with the T compared to the C allele of rs780094 (p = 0.009 and 0.044, respectively). T-genotype carriers also exhibited a higher frequency of low HDL-C levels (p = 0.028) than noncarriers, although MetS frequency was similar between the two groups. After adjusting for confounding factors, the odds ratios for low HDL-C levels and MetS incidence in T-genotype carriers were 1.64 (95% confidence interval [CI]: 1.07-2.53) and 2.79 (95% CI: 1.09-7.11), respectively.
  
  
  CONCLUSIONS
  The GCKR rs780094 polymorphism is associated with low HDL-C levels and MetS incidence in Taiwanese adolescents.
authors.affiliation: 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .|2 Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital , Kaohsiung, Taiwan .
authors.forename: Hsiao-Wen
authors.initials: HW
authors.lastname: Chang
authors.affiliation: 3 School of Public Health, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .
authors.forename: Fu-Huang
authors.initials: FH
authors.lastname: Lin
authors.affiliation: 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Li
authors.affiliation: 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .
authors.forename: Chia-Luen
authors.initials: CL
authors.lastname: Huang
authors.affiliation: 3 School of Public Health, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .|4 Taitung Hospital , DOH, Taitung City, Taiwan .
authors.forename: Nain-Feng
authors.initials: NF
authors.lastname: Chu
authors.affiliation: 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .
authors.forename: Sheng-Chiang
authors.initials: SC
authors.lastname: Su
authors.affiliation: 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .
authors.forename: Chieh-Hua
authors.initials: CH
authors.lastname: Lu
authors.affiliation: 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .
authors.forename: Chien-Hsing
authors.initials: CH
authors.lastname: Lee
authors.affiliation: 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Hung
authors.affiliation: 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .
authors.forename: Chang-Hsun
authors.initials: CH
authors.lastname: Hsieh
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000097:blood / Q000235:genetics*; D000293:Adolescent; D000367:Age Factors; D000483:Alleles; D044466:Asian People; D002648:Child; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005941:Glucokinase / Q000097:blood / Q000235:genetics; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood / Q000235:genetics; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C485100:GCKR protein, human; D008075:Lipoproteins, HDL; D014280:Triglycerides; D005941:Glucokinase