title: Use of porcine acellular dermal matrix following early dermabrasion reduces length of stay in extensive deep dermal burns.
abstract: OBJECTIVE
  Extensive deep partial-thickness burns still seriously challenge the surgeon's abilities. This study aimed to assess the impact of early dermabrasion combined with porcine acellular dermal matrix (ADM) in extensive deep dermal burns.
  
  
  METHODS
  From September 2009 to September 2013, a total of 60 adult patients sustained greater than 50% total body surface area (TBSA) burn by hot water or gas explosion were divided into three groups based on dermabrasion: group A (early dermabrasion and porcine ADM), group B (early dermabrasion and nano-silver dressings), and group C (conservative group). The wound healing time and length of hospital stay were analyzed. Scar assessment was performed at 3 and 12 months after the injury with a modified Vancouver Scar Scale linked with TBSA (mVSS-TBSA).
  
  
  RESULTS
  No significant difference was found in mean burn size, burn depth, age, male-to-female ratio, or incidence of inhalation injury between the patients in the three groups (p>0.05). Compared with groups B and C, the patients that received early dermabrasion combined with porcine ADM had a shorter wound healing time (p<0.01). The burn patients treated with early dermabrasion and porcine ADM coverage had a mean length of hospital stay of 28.3 days (±7.2), which was significantly shorter than that of groups B and C (p<0.05-0.01). The mVSS-TBSA of patients in group A was significantly improved in comparison with groups B and C at 3 and 12 months after the injury. There was no significant difference in the mortality rate between the three groups (p>0.05).
  
  
  CONCLUSIONS
  Early dermabrasion combined with porcine ADM coverage facilitates wound healing, reduces the length of hospital stay, and improves esthetic and functional results in extensive deep dermal burns with burn size over 50% TBSA.
authors.affiliation: Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, PR China; Department of Burns and Plastic Surgery, No. 174 Hospital of PLA, Xiamen, Fujian 361003, PR China.
authors.forename: Zhi-Qian
authors.initials: ZQ
authors.lastname: Guo
authors.affiliation: Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, PR China.
authors.forename: Le
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Department of Burns and Plastic Surgery, No. 174 Hospital of PLA, Xiamen, Fujian 361003, PR China.
authors.forename: You
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Burns and Plastic Surgery, No. 174 Hospital of PLA, Xiamen, Fujian 361003, PR China.
authors.forename: Jin-Hu
authors.initials: JH
authors.lastname: Li
authors.affiliation: Department of Burns and Plastic Surgery, No. 174 Hospital of PLA, Xiamen, Fujian 361003, PR China.
authors.forename: Xin-He
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: Department of Burns and Plastic Surgery, No. 174 Hospital of PLA, Xiamen, Fujian 361003, PR China.
authors.forename: Xin-Lei
authors.initials: XL
authors.lastname: Yang
authors.affiliation: Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, PR China.
authors.forename: April
authors.initials: A
authors.lastname: Peszel
authors.affiliation: Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, PR China. Electronic address: xulinchen@126.com.
authors.forename: Xu-Lin
authors.initials: XL
authors.lastname: Chen
mesh_terms: D062088:Acellular Dermis; D000328:Adult; D000818:Animals; D001830:Body Surface Area; D002056:Burns / Q000628:therapy*; D002921:Cicatrix; D000072700:Conservative Treatment; D003869:Dermabrasion; D061345:Early Medical Intervention; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018030:Silver Compounds / Q000627:therapeutic use*; D016038:Skin Transplantation; D013552:Swine; D015599:Trauma Severity Indices; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D018030:Silver Compounds
keywords: Acellular dermal matrix; Deep dermal burns; Dermabrasion