title: Palladium-catalyzed highly atom-economical allylation of oxindoles with vinyl cyclopropanes.
abstract: A highly atom-economical allylation of oxindoles with vinyl cyclopropanes catalyzed by Pd(PPh3)4 has been developed, setting up a practical venue for the installation of an all-carbon quaternary center at the 3-position in oxindoles under mild reaction conditions. Importantly, the reaction proceeded well without any additives and no waste was produced, affording linear products with high regioselectivities (>20 : 1). Enantioselective allylic alkylation has also been realized to provide the desired products in good yields and 35% ee.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, P. R. China. gxjiang@licp.cas.cn.
authors.forename: Ruwei
authors.initials: R
authors.lastname: Cao
authors.forename: Jinlong
authors.initials: J
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.forename: Huameng
authors.initials: H
authors.lastname: Yang
authors.forename: Gaoxi
authors.initials: G
authors.lastname: Jiang