title: Loin pain hematuria syndrome.
abstract: Loin pain hematuria syndrome (LPHS), first described in 1967, is a rare pain syndrome, which is not well understood. The syndrome is characterized by severe intermittent or persistent flank pain, either unilateral or bilateral, associated with gross or microscopic hematuria. LPHS is a diagnosis of exclusion as there still is not a consensus of validated diagnostic criteria, though several criteria have been proposed. The wide differential diagnosis would suggest a meticulous yet specific diagnostic work-up depending on the individual clinical features and natural history. Several mechanisms regarding the pathophysiology of LPHS have been proposed but without pinpointing the actual causative etiology, the treatment remains symptomatic. Treatment modalities for LPHS are diverse including simple analgesia, opioid analgesic and kidney autotransplantation. This review article summarizes the current understanding regarding the pathophysiology of LPHS along with the steps required for proper diagnosis and a discussion of the different therapeutic approaches for LPHS.
authors.affiliation: Division of Transplantation Surgery, Department of Medicine , Mayo Clinic , Rochester, MN , USA.
authors.forename: Adeel S
authors.initials: AS
authors.lastname: Zubair
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine , Mayo Clinic College of Medicine , Rochester, MN , USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Salameh
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine , Mayo Clinic College of Medicine , Rochester, MN , USA.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Erickson
authors.affiliation: Division of Transplantation Surgery, Department of Medicine , Mayo Clinic , Rochester, MN , USA.
authors.forename: Mikel
authors.initials: M
authors.lastname: Prieto
keywords: autotransplant; flank pain; hematuria; loin pain hematuria syndrome