title: Prevalence of Helicobacter pylori in benign gastric ulcers in a cohort of Sri Lankan patients.
abstract: Helicobacter pylori prevalence is decreasing globally and prevalence of non H. pylori gastric ulcers is increasing. The following study was conducted to assess the prevalence of H. pylori in benign gastric ulcers in a sample of Sri Lankan patients. This was a cross-sectional study of 59 dyspeptic patients with benign gastric ulcers. Multiple endoscopic gastric biopsies were obtained and histology, immunohistochemistry and polymerase chain reaction were performed for H. pylori detection. An immunochromatography assay was performed to detect blood anti H. pylori antibodies. Four (6.8%) were positive for H. pylori. Therefore, it is likely that most benign gastric ulcers are of non-H. pylori aetiology.
authors.affiliation: Department of Pathology,Faculty of Medicine, University of Peradeniya, Sri Lanka. suwijetunge@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Wijetunge
authors.forename: R
authors.initials: R
authors.lastname: Kotakadeniya
authors.forename: F
authors.initials: F
authors.lastname: Noordeen
authors.forename: S M
authors.initials: SM
authors.lastname: Buharideen
authors.forename: B
authors.initials: B
authors.lastname: Samarasinghe
authors.forename: A
authors.initials: A
authors.lastname: Dharmapala
authors.forename: K B
authors.initials: KB
authors.lastname: Galketiya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000276:immunology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D016480:Helicobacter pylori / Q000235:genetics / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D013188:Sri Lanka / Q000453:epidemiology; D013276:Stomach Ulcer / Q000453:epidemiology* / Q000382:microbiology; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D012336:RNA, Ribosomal, 16S