title: Evaluation of genetic association of neurodevelopment and neuroimmunological genes with antipsychotic treatment response in schizophrenia in Indian populations.
abstract: Neurodevelopmental and neuroimmunological genes critically regulate antipsychotic treatment outcome. We report genetic associations of antipsychotic response in 742 schizophrenia patients from Indian populations of Indo-European and Dravidian ancestry, segregated by disease severity. Meta-analysis comparing the two populations identified CCL2 [rs4795893: OR (95% CI) = 1.79 (1.27-2.52), P = 7.62 × 10(-4); rs4586: OR (95% CI) = 1.74 (1.24-2.43), P = 1.13 × 10(-3)] and GRIA4 [rs2513265: OR (95% CI) = 0.53 (0.36-0.78), P = 1.44 × 10(-3)] in low severity group; and, ADCY2 [rs1544938: OR (95% CI) = 0.36 (0.19-0.65), P = 7.68 × 10(-4)] and NRG1 [rs13250975, OR (95% CI) = 0.42 (0.23-0.79), P = 6.81 × 10(-3); rs17716295, OR (95% CI) = 1.78 (1.15-2.75), P = 8.71 × 10(-3)] in high severity group, with incomplete response toward antipsychotics. To our knowledge, this is the first study to identify genetic polymorphisms associated with the efficacy of antipsychotic treatment of schizophrenia patients from two major India populations.
authors.affiliation: Genomics and Molecular Medicine CSIR-Institute of Genomics and Integrative Biology Mall Road Delhi 110007 India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Jajodia
authors.affiliation: Genomics and Molecular Medicine CSIR-Institute of Genomics and Integrative Biology Mall Road Delhi 110007 India.
authors.forename: Harpreet
authors.initials: H
authors.lastname: Kaur
authors.affiliation: Department of Psychiatry All India Institute of Medical Sciences Ansari Nagar New Delhi 110029 India.
authors.forename: Kalpana
authors.initials: K
authors.lastname: Kumari
authors.affiliation: Genomics and Molecular Medicine CSIR-Institute of Genomics and Integrative Biology Mall Road Delhi 110007 India.
authors.forename: Neha
authors.initials: N
authors.lastname: Kanojia
authors.affiliation: Genomics and Molecular Medicine CSIR-Institute of Genomics and Integrative Biology Mall Road Delhi 110007 India.
authors.forename: Meenal
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Genomics and Molecular Medicine CSIR-Institute of Genomics and Integrative Biology Mall Road Delhi 110007 India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Baghel
authors.affiliation: Department of Psychiatry All India Institute of Medical Sciences Ansari Nagar New Delhi 110029 India.
authors.forename: Mamta
authors.initials: M
authors.lastname: Sood
authors.affiliation: Molecular Genetic Laboratory Department of Psychiatry National Institute of Mental Health and Neuro Sciences Hosur Road Bengaluru 560029 India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Jain
authors.affiliation: Department of Psychiatry All India Institute of Medical Sciences Ansari Nagar New Delhi 110029 India.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Chadda
authors.affiliation: Genomics and Molecular Medicine CSIR-Institute of Genomics and Integrative Biology Mall Road Delhi 110007 India.
authors.forename: Ritushree
authors.initials: R
authors.lastname: Kukreti
keywords: Antipsychotic; meta‐analysis; neurodevelopment; pharmacogenomics; severity