title: [A Case of Long-Term Survival of Advanced Esophageal Basaloid Squamous Carcinoma Invading the Trachea].
abstract: A woman in her 50s complained of dysphagia and was diagnosed with locally advanced esophageal cancer in the middle and upper thoracic esophagus, invading the tracheal bronchus. The biopsy indicated esophageal basaloid squamous carcinoma. The pretreatment diagnosis was cT4N2M0, cStage Ⅳa. She was treated with systemic chemotherapy consisting of FAP (5-fluorouracil [5-FU], doxorubicin [DXR] and cisplatin[CDDP]), which resulted in significant tumor shrinkage. One year later, the tumor regrew, and nedaplatin (CDGP) plus docetaxel (DOC) was administered as second-line chemotherapy. The patient complained of dysphagia during the course of chemotherapy, and received radiation therapy for the residual tumor, which again significantly shrunk. Four years after the first round of chemotherapy, the patient can take oral nutrition, and is continuing to undergo chemotherapy. This is a case of long-term survival of locally advanced esophageal cancer of basaloid squamous carcinoma. Effective chemotherapy and radiation can improve the treatment outcome.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Ohtsuka Hospital.
authors.forename: Michiyo
authors.initials: M
authors.lastname: Tokura
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Murata
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Mayumi
authors.initials: M
authors.lastname: Hoshino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Goto
authors.forename: Masaki
authors.initials: M
authors.lastname: Kakimoto
authors.forename: Haruya
authors.initials: H
authors.lastname: Koshiishi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D003680:Deglutition Disorders / Q000209:etiology; D004938:Esophageal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D013997:Time Factors; D014132:Trachea / Q000473:pathology*