title: Serum copeptin and pregnancy outcome in preeclampsia.
abstract: BACKGROUND
  A number of biochemical predictors of preeclampsia have been reported, but little is known about their possible relationship with maternal and fetal outcomes. This study determined serum copeptin in pregnant women with preeclampsia and assessed its relationship with pregnancy outcomes.
  
  
  METHODS
  Thirty women with severe preeclampsia (SP), 30 with mild preeclampsia (MP), and 30 with uncomplicated pregnancy were enrolled into this study. Serum copeptin, creatinine, and liver function were determined using enzyme-linked immunosorbent assay and colorimetry as appropriate. Pregnancy outcomes, both maternal and fetal, were taken using standard methods.
  
  
  RESULTS
  Copeptin was significantly elevated in preeclampsia subjects compared with controls and in SP compared with MP. Assessing the diagnostic property of copeptin for preeclampsia, the area under the curve for copeptin was 0.99. Nine (30%) and 3 (10%) of SP and MP, respectively had abruptio placenta while 6 (20%), 2 (6.7%), and 1 (3.3%) still births were recorded in SP, MP, and controls, respectively. Neonates of mothers with preeclampsia had significantly lower birth weight, infant length, ponderal index, and head circumference compared with neonates of the controls. Copeptin had a significant inverse relationship with birth weight, ponderal index, head circumference, Apgar score, and infant length in neonates of mothers with preeclampsia.
  
  
  CONCLUSIONS
  Serum copeptin level in the third trimester could predict preeclampsia and its elevation is associated with adverse perinatal outcome.
authors.affiliation: Department of Chemical Pathology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
authors.forename: Kehinde Sola
authors.initials: KS
authors.lastname: Akinlade
authors.affiliation: Department of Chemical Pathology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
authors.forename: Isaac Oluwole
authors.initials: IO
authors.lastname: Adediji
authors.affiliation: Department of Chemical Pathology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
authors.forename: Sheu Kadiri
authors.initials: SK
authors.lastname: Rahamon
authors.affiliation: Department of Obstetrics and Gynaecology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
authors.forename: Adeniran Olubukola
authors.initials: AO
authors.lastname: Fawole
authors.affiliation: Department of Paediatrics, University of Ibadan/University College Hospital, Ibadan, Nigeria.
authors.forename: Olukemi Oluwatoyin
authors.initials: OO
authors.lastname: Tongo
keywords: Abruptio placenta; Apgar score; copeptin; perinatal outcome; ponderal index; preeclampsia