title: Increased intake of vegetables, but not fruits, may be associated with reduced risk of hip fracture: A meta-analysis.
abstract: Association between dietary intake of vegetables and fruits and risk of hip fracture has been reported for many years. However, the findings remain inconclusive. We conducted a meta-analysis to evaluate the relationship between intake of vegetables and fruits, and risk of hip fracture. Literature search for relevant studies was performed on PubMed and Embase databases. Five observational studies were included in the meta-analysis. Summary hazard ratio (HR) with corresponding 95% confidence interval (CI) was calculated from pooled data using the random-effects model irrespective of heterogeneity. Sensitivity and subgroup analysis were performed to explore possible reasons for heterogeneity. The summary HR for hip fracture in relation to high intake vs. low intake of only vegetables, only fruits, and combined intake of fruits and vegetables, was 0.75 (95% CI, 0.61-0.92), 0.87 (95% CI, 0.74-1.04), and 0.79 (95% CI, 0.61-1.03), respectively. Subgroup analyses based on study design, geographical location, number of cases, and gender showed similar results. Increased intake of vegetables, but not fruits, was found to be associated with a lower risk of hip fracture. Large prospective clinical trials with robust methodology are required to confirm our findings.
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou provincial people's hospital, Guiyang, China.
authors.forename: Si yang
authors.initials: Sy
authors.lastname: Luo
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou provincial people's hospital, Guiyang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou provincial people's hospital, Guiyang, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Luo
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou provincial people's hospital, Guiyang, China.
authors.forename: Xin hai
authors.initials: Xh
authors.lastname: Yin
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou provincial people's hospital, Guiyang, China.
authors.forename: Du ren
authors.initials: du R
authors.lastname: Lin
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou provincial people's hospital, Guiyang, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou provincial people's hospital, Guiyang, China.
authors.forename: Guang lei
authors.initials: Gl
authors.lastname: Huang
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou provincial people's hospital, Guiyang, China.
authors.forename: Ju kun
authors.initials: Jk
authors.lastname: Song
mesh_terms: D005247:Feeding Behavior; D005500:Follow-Up Studies; D005638:Fruit; D006620:Hip Fractures / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D016016:Proportional Hazards Models; D012306:Risk; D014675:Vegetables