title: Frequency of the Original Kidney Disease and Its Effect on the Outcome of Kidney Transplant in the Urology-Nephrology Center Mansoura University.
abstract: OBJECTIVE
  Renal allograft function and graft survival depends on many factors, including the source of the graft, immunologic matching between donor and recipient, incidence of acute rejection, and recurrence of the original kidney disease. This work aimed to evaluate the effects of the original kidney disease on patient and graft survival.
  
  
  METHODS
  This was a retrospective, single-center study that included 2189 kidney transplant recipients who were transplanted at The Urology and Nephrology Centre, Mansoura University, between 1976 and 2010. Of 2189 recipients, 1350 patients with unknown original kidney disease were excluded, with the remaining 839 patients divided into 4 groups according to their original kidney disease.
  
  
  RESULTS
  We found pretransplant dialysis and blood transfusion to be statistically significant among the 4 groups. Regarding induction immunosuppressive therapy, a statistical significance was found between the 4 groups regarding the presence and type of induction therapy, with no statistical significance regarding the type of maintenance immunosuppression. There was no statistical significance between the 4 groups regarding the incidence of acute and chronic rejection. We also found recurrence of original kidney disease to be statistically significant in the 4 groups, particularly in the group that included patients with glomerular disease, where the highest rate of recurrence was reported in patients with focal segmental glomerulosclerosis and membranoproliferative glomerulonephritis, and patient and graft survival was also statistically significant.
  
  
  CONCLUSIONS
  The original kidney disease has an effect on renal allograft function and graft and patient survival.
authors.affiliation: From the Department of Dialysis and Transplantation, The Urology-Nephrology Center, Mansoura University, Mansoura, Egypt.
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Mashaly
authors.forename: Mabrouk I
authors.initials: MI
authors.lastname: Ismail
authors.forename: Esam E
authors.initials: EE
authors.lastname: Lotfy
authors.forename: Ahmed F
authors.initials: AF
authors.lastname: Donia
authors.forename: Ihab W
authors.initials: IW
authors.lastname: Wafa
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Foda
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Denewar
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: Abbas
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Shokeir
mesh_terms: D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D006435:Renal Dialysis / Q000009:adverse effects; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D065227:Transfusion Reaction; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents