title: [Basic Studies on Locoregional Injection of a Newly Designed Chitin Sol].
abstract: BACKGROUND
  Systemic chemotherapy in advanced cancer cases often provokes serious adverse events.
  
  
  OBJECTIVE
  We aimed to examine the fundamental properties and efficacy of a novel chitin sol, an anti-cancer agent with minor side effects designed to avoid the adverse effects of chemotherapy and enhance the QOL and ADL of patients.
  
  
  METHODS
  DAC-70 was used to create the novel agent termed DAC-70 sol. The anti-proliferative activity was assayed by the WST method using different types of cell lines. The anti-cancer efficacy of the novel agent was examined using cancer-bearing mice.
  
  
  RESULTS
  DAC-70 sol was easily injectable through a 21-G needle. The sol suppressed proliferation of the cells in vitro. Intra-tumor injection of DAC-70 sol inhibited the rapid growth of solid tumors in the mice. CDDP-loaded DAC-70 sol, CDDP/DAC-70 sol, successfully controlled malignant ascites in the mice (p<0.05). Neither recurrence nor severe complications were encountered in these animals.
  
  
  CONCLUSIONS
  These basic data strongly suggest that locoregional administration of our newly designed DAC-70 sol and CDDP/DAC-70 sol is clinically useful as novel cancer chemotherapy for advanced cases. This warrants further clinical studies in cancer chemotherapy.
authors.affiliation: Dept. of Surgery, Iwate Medical University.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Chiba
authors.forename: Akio
authors.initials: A
authors.lastname: Sugitachi
authors.forename: Kouhei
authors.initials: K
authors.lastname: Kume
authors.forename: Takenori
authors.initials: T
authors.lastname: Segawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishinari
authors.forename: Kaoru
authors.initials: K
authors.lastname: Ishida
authors.forename: Hironobu
authors.initials: H
authors.lastname: Noda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishizuka
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kimura
authors.forename: Keisuke
authors.initials: K
authors.lastname: Koeda
authors.forename: Akira
authors.initials: A
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D001201:Ascites / Q000209:etiology; D045744:Cell Line, Tumor; D002686:Chitin / Q000627:therapeutic use*; D018450:Disease Progression; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D023041:Xenograft Model Antitumor Assays
chemical_list: D002686:Chitin