title: An Evolutionary View of the Arms Race between Protein Kinase R and Large DNA Viruses.
abstract: To establish productive infections, viruses must counteract numerous cellular defenses that are poised to recognize viruses as nonself and to activate antiviral pathways. The opposing goals of host and viral factors lead to evolutionary arms races that can be illuminated by evolutionary and computational methods and tested in experimental models. Here we illustrate how this perspective has been contributing to our understanding of the interactions of the protein kinase R pathway with large DNA viruses.
authors.affiliation: Departments of Microbiology and Medicine, University of Washington, Seattle, Washington, USA Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: Kathryn S
authors.initials: KS
authors.lastname: Carpentier
authors.affiliation: Departments of Microbiology and Medicine, University of Washington, Seattle, Washington, USA Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA ageballe@fredhutch.org.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Geballe
mesh_terms: D000818:Animals; D004266:DNA Virus Infections / Q000201:enzymology / Q000276:immunology*; D004267:DNA Viruses / Q000276:immunology*; D015852:Eukaryotic Initiation Factor-2 / Q000378:metabolism; D019143:Evolution, Molecular; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007372:Interferons / Q000276:immunology; D012330:RNA, Double-Stranded / Q000235:genetics / Q000378:metabolism; D019892:eIF-2 Kinase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D015852:Eukaryotic Initiation Factor-2; D012330:RNA, Double-Stranded; D007372:Interferons; D019892:eIF-2 Kinase