title: Mesoporous silica nanoparticles in tissue engineering--a perspective.
abstract: In this review, we summarize the latest developments and give a perspective on future applications of mesoporous silica nanoparticles (MSNs) in regenerative medicine. MSNs constitute a flexible platform for controlled delivery of drugs and imaging agents in tissue engineering and stem cell therapy. We highlight the recent advances in applying MSNs for controlled drug delivery and stem cell tracking. We touch upon novel functions of MSNs in real time imaging of drug release and biological function, and as tools to control the chemical and mechanical environment of stem cells. We discuss the need for novel model systems for studying biofunctionality and biocompatibility of MSNs, and how the interdisciplinary activities within the field will advance biotechnology research.
authors.affiliation: Pharmaceutical Sciences Laboratory, Faculty of Science & Engineering, Åbo Akademi University, Tykistökatu 6A, FIN-20521, Turku, Finland.
authors.forename: Jessica Maria
authors.initials: JM
authors.lastname: Rosenholm
authors.affiliation: Key Laboratory of Biorheological Science & Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174 Shazheng Road, Chongqing 400044, China.
authors.forename: Jixi
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Inorganic Chemistry II, Ulm University, Albert-Einstein-Allee 11, D-89081 Ulm, Germany.
authors.forename: Mika
authors.initials: M
authors.lastname: Linden
authors.affiliation: Turku Centre for Biotechnology, University of Turku & Åbo Akademi University, FI-20520 Turku, Finland.|Department of Biomedical Engineering, Technical University of Eindhoven, 5613 DR Eindhoven, The Netherlands.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Sahlgren
mesh_terms: D001672:Biocompatible Materials; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D012822:Silicon Dioxide
keywords: biosensing; controlled drug delivery; instructive biomaterials; mesoporous silica nanoparticles; regenerative therapy; stem cell imaging; stem cell microenvironment