title: Synchronous double primary cancer - intrahepatic cholangiocarcinoma with bone metastases and thyroid carcinoma: A case report.
abstract: There is a low incidence of multiple primary cancer, particularly when the cancer is synchronous. The present report presents a case of synchronous double primary malignancies. A 58-year-old woman was admitted to Ling Nan Hospital (Guangzhou, China) complaining of pain in the left hip. X-ray revealed an osteolytic lesion and further examination indicated the presence of double primary cancer, consisting of hepatic cholangiocarcinoma and thyroid carcinoma. Biopsy of the osteolytic lesion showed a metastatic adenocarcinoma of unknown origin. Subsequently, final diagnosis was confirmed by I-131 scan and liver lesion biopsy. The patient received positive multidisciplinary treatments and survived for 9 months following diagnosis. The results of the present case suggest that multiplicity of primary malignancy is not necessarily an indicator of poor prognosis, as long as effective diagnosis and adequate disease management are achieved.
authors.affiliation: Department of General Surgery, Ling Nan Hospital, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510530, P.R. China.
authors.forename: Qing-Liang
authors.initials: QL
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, Ling Nan Hospital, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510530, P.R. China.
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Li
authors.affiliation: Department of General Surgery, Ling Nan Hospital, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510530, P.R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, Ling Nan Hospital, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510530, P.R. China.
authors.forename: B O
authors.initials: BO
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Ling Nan Hospital, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510530, P.R. China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Ye
keywords: bone metastases; double primary cancers; intrahepatic cholangiocarcinoma; therapy; thyroid carcinoma