title: Transient Intraoperative Central Diabetes Insipidus in Moyamoya Patients Undergoing Revascularization Surgery: A Mere Coincidence?
abstract: We present 2 patients with Moyamoya disease undergoing revascularization surgery who developed transient intraoperative central diabetes insipidus with spontaneous resolution in the immediate postoperative period. We speculate that patients with Moyamoya disease may be predisposed to a transient acute-on-chronic insult to the arginine vasopressin-producing portion of their hypothalamus mediated by anesthetic agents. We describe our management, discuss pertinent literature, and offer possible mechanisms of this transient insult. We hope to improve patient safety by raising awareness of this potentially catastrophic complication.
authors.affiliation: From the *Department of Anesthesiology and Perioperative Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California; and †Medical Student, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California.
authors.forename: Joe C
authors.initials: JC
authors.lastname: Hong
authors.forename: Emilio
authors.initials: E
authors.lastname: Ramos
authors.forename: Curtis C
authors.initials: CC
authors.lastname: Copeland
authors.forename: Keren
authors.initials: K
authors.lastname: Ziv
mesh_terms: D061605:Administration, Intravenous; D001127:Arginine Vasopressin / Q000008:administration & dosage* / Q000627:therapeutic use; D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000150:complications* / Q000601:surgery*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects*
chemical_list: D001127:Arginine Vasopressin