title: [A Case of Taxane-Pretreated Metastatic Gastric Cancer with Excellent Response to Nab-Paclitaxel].
abstract: We present a rare case of taxane-pretreated metastatic gastric cancer with an excellent response to nab-paclitaxel. A 66- year-old woman was diagnosed with Stage Ⅳ gastric adenocarcinoma (T4aN3M1[LYM, OTH]P1CY1). She failed to respond to multiple chemotherapeutic regimens including S-1, capecitabine, cisplatin, L-OHP, paclitaxel, docetaxel, and CPT- 11. Finally, 6th line chemotherapy with nab-paclitaxel was tried. After 4 courses of nab-paclitaxel, a CT scan revealed decreasing ascites and a reduction in the size of the ovary metastasis. She experienced a clinical response for about 4 months. The adverse events were only Grade 1 peripheral sensory neuropathy and joint pain, and her performance status improved during the treatment period.
authors.affiliation: Dept. of Surgery, Osaka Rosai Hospital.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Kawabata
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kimura
authors.forename: Tomono
authors.initials: T
authors.lastname: Kawase
authors.forename: Masato
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Chizu
authors.initials: C
authors.lastname: Kameda
authors.forename: Tae
authors.initials: T
authors.lastname: Matsumura
authors.forename: Chikato
authors.initials: C
authors.lastname: Koga
authors.forename: Masahiro
authors.initials: M
authors.lastname: Murakami
authors.forename: Masaki
authors.initials: M
authors.lastname: Hirota
authors.forename: Shingo
authors.initials: S
authors.lastname: Noura
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ikenaga
authors.forename: Junzo
authors.initials: J
authors.lastname: Shimizu
authors.forename: Junichi
authors.initials: J
authors.lastname: Hasegawa
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000418:Albumins / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000556:secondary; D017239:Paclitaxel / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000627:therapeutic use*
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D000972:Antineoplastic Agents, Phytogenic; D001952:Bridged-Ring Compounds; D043823:Taxoids; C080625:taxane; D017239:Paclitaxel