title: Manganese superoxide dismutase, glutathione peroxidase and catalase gene polymorphisms and clinical outcomes in acute kidney injury.
abstract: BACKGROUND
  The aim of this study was to evaluate the potential association of single gene polymorphisms of manganese superoxide dismutase (MnSOD), glutathione peroxidase 1 (GPX1) and catalase (CAT) with clinical outcomes of acute kidney injury (AKI).
  
  
  METHODS
  Ninety AKI patients and 101 healthy volunteers were included in the study. Determination of MnSOD rs4880, GPX1 rs1050450 and CAT rs769217 polymorphisms was performed using real-time polymerase chain reaction amplification. The duration of hospitalization of AKI patients, dialysis and intensive care requirements, sepsis, oliguria and in-hospital mortality rates were assessed.
  
  
  RESULTS
  The MnSOD, GPX1 and CAT genotypes and allele frequencies of AKI patients did not differ significantly from those of healthy controls. In patients with a T allele in the ninth exon of the CAT gene, intensive care requirements were greater than those of patients with the CC genotype (p = 0.04). In addition, sepsis and in-hospital mortality were observed significantly more frequently in patients with a T allele in the ninth exon of the CAT gene (p = 0.03). Logistic regression analysis determined that bearing a T allele was the primary determinant of intensive care requirements and in-hospital mortality, independent of patient age, gender, presence of diabetes and dialysis requirements (OR 6.10, 95% CI 1.34-27.81, p = 0.02 and OR 10.25, 95% CI 1.13-92.80, p = 0.04, respectively).
  
  
  CONCLUSIONS
  Among AKI patients in the Turkish population, hospital morbidity and mortality were found to be more frequent in patients bearing a T allele of the rs769217 polymorphism of the CAT gene.
authors.affiliation: a Division of Nephrology, Department of Internal Medicine, Faculty of Medicine , Suleyman Demirel University , Isparta , Turkey ;
authors.forename: Veysel
authors.initials: V
authors.lastname: Kidir
authors.affiliation: b Department of Medical Biochemistry, Faculty of Medicine , Suleyman Demirel University , Isparta , Turkey ;
authors.forename: Efkan
authors.initials: E
authors.lastname: Uz
authors.affiliation: c Department of Medical Biology, Faculty of Medicine , Suleyman Demirel University , Isparta , Turkey ;
authors.forename: Ayse
authors.initials: A
authors.lastname: Yigit
authors.affiliation: a Division of Nephrology, Department of Internal Medicine, Faculty of Medicine , Suleyman Demirel University , Isparta , Turkey ;
authors.forename: Atila
authors.initials: A
authors.lastname: Altuntas
authors.affiliation: c Department of Medical Biology, Faculty of Medicine , Suleyman Demirel University , Isparta , Turkey ;
authors.forename: Barbaros
authors.initials: B
authors.lastname: Yigit
authors.affiliation: a Division of Nephrology, Department of Internal Medicine, Faculty of Medicine , Suleyman Demirel University , Isparta , Turkey ;
authors.forename: Salih
authors.initials: S
authors.lastname: Inal
authors.affiliation: d Division of Nephrology, Department of Internal Medicine, Faculty of Medicine , Atatürk Education and Research Hospital, Yildirim Beyazit University , Ankara , Turkey ;
authors.forename: Ebru
authors.initials: E
authors.lastname: Uz
authors.affiliation: a Division of Nephrology, Department of Internal Medicine, Faculty of Medicine , Suleyman Demirel University , Isparta , Turkey ;
authors.forename: Mehmet Tugrul
authors.initials: MT
authors.lastname: Sezer
authors.affiliation: e Department of Medical Biology, Faculty of Medicine , Mevlana University , Konya , Turkey.
authors.forename: H Ramazan
authors.initials: HR
authors.lastname: Yilmaz
mesh_terms: D058186:Acute Kidney Injury / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D002374:Catalase / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005979:Glutathione Peroxidase / Q000235:genetics*; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000235:genetics*; D014421:Turkey; D000094765:Glutathione Peroxidase GPX1
chemical_list: D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human
keywords: Acute kidney injury; catalase; gene polymorphism; glutathione peroxidase; manganese superoxide dismutase