title: Mitochondria to motion: optimizing oxidative phosphorylation to improve exercise performance.
abstract: Mitochondria oxidize substrates to generate the ATP that fuels muscle contraction and locomotion. This review focuses on three steps in oxidative phosphorylation that have independent roles in setting the overall mitochondrial ATP flux and thereby have direct impact on locomotion. The first is the electron transport chain, which sets the pace for oxidation. New studies indicate that the electron transport chain capacity per mitochondria declines with age and disease, but can be revived by both acute and chronic treatments. The resulting higher ATP production is reflected in improved muscle power output and locomotory performance. The second step is the coupling of ATP supply from O2 uptake (mitochondrial coupling efficiency). Treatments that elevate mitochondrial coupling raise both exercise efficiency and the capacity for sustained exercise in both young and old muscle. The final step is ATP synthesis itself, which is under dynamic control at multiple sites to provide the 50-fold range of ATP flux between resting muscle and exercise at the mitochondrial capacity. Thus, malleability at sites in these subsystems of oxidative phosphorylation has an impact on ATP flux, with direct effects on exercise performance. Interventions are emerging that target these three independent subsystems to provide many paths to improve ATP flux and elevate the muscle performance lost to inactivity, age or disease.
authors.affiliation: Departments of Radiology, Physiology & Biophysics, and Bioengineering, University of Washington Medical Center, Seattle, WA 98195, USA kconley@uw.edu.
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Conley
mesh_terms: D000818:Animals; D004579:Electron Transport; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009038:Motion; D010085:Oxidative Phosphorylation; D010766:Phosphorylation
keywords: Exercise capacity; Exercise efficiency; Magnetic resonance spectroscopy; Mitochondrial coupling; Muscle energetics; P/O