title: Omega-3 Fatty Acids and their Role in Central Nervous System - A Review.
abstract: Polyunsaturated fatty acids (PUFAs) are crucial for our health and wellbeing; therefore, they have been widely investigated for their roles in maintaining human health and in disease treatment. Most Western diets include significant amount of saturated and omega-6 fatty acids and insufficient quantity of omega-3; however, the balance between omega-6 and omega-3 PUFA, in particular, is essential for the formation of pro- and anti-inflammatory lipids to promote health and prevent disease. As our daily diet affects our health, this paper draws attention to unique representatives of the omega-3 fatty acid group: alpha-linolenic acid and its derivatives. Recently, this has been shown to be effective in treating and preventing various diseases. It has been confirmed that omega-3 PUFAs may act as therapeutic agents as well and their significant role against inflammatory diseases, such as cardiovascular and neurodegenerative diseases, has been described. Some of nutritional factors have been described as a significant modifiers, which can influence brain elasticity and thus, effect on central nervous system functioning. Therefore, appropriate dietary management appears to be a non-invasive and effective approach to counteract neurological and cognitive disorders.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Wysoczański
authors.forename: Ewa
authors.initials: E
authors.lastname: Sokoła-Wysoczańska
authors.affiliation: Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland. pekala.jolanta@gmail.com.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Pękala
authors.forename: Stanisław
authors.initials: S
authors.lastname: Lochyński
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Czyż
authors.forename: Robert
authors.initials: R
authors.lastname: Bodkowski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Herbinger
authors.forename: Bożena
authors.initials: B
authors.lastname: Patkowska-Sokoła
authors.affiliation: Department of Radioligands, Collegium Medicum, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland. mflibrow@cyf-kr.edu.pl.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Librowski
mesh_terms: D002490:Central Nervous System / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000178:diet therapy* / Q000378:metabolism / Q000517:prevention & control*; D003072:Cognition Disorders / Q000178:diet therapy / Q000378:metabolism / Q000517:prevention & control; D015525:Fatty Acids, Omega-3 / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure
chemical_list: D015525:Fatty Acids, Omega-3