title: Accuracy of finite element analyses of CT scans in predictions of vertebral failure patterns under axial compression and anterior flexion.
abstract: Finite element (FE) models built from quantitative computed tomography (QCT) scans can provide patient-specific estimates of bone strength and fracture risk in the spine. While prior studies demonstrate accurate QCT-based FE predictions of vertebral stiffness and strength, the accuracy of the predicted failure patterns, i.e., the locations where failure occurs within the vertebra and the way in which the vertebra deforms as failure progresses, is less clear. This study used digital volume correlation (DVC) analyses of time-lapse micro-computed tomography (μCT) images acquired during mechanical testing (compression and anterior flexion) of thoracic spine segments (T7-T9, n=28) to measure displacements occurring throughout the T8 vertebral body at the ultimate point. These displacements were compared to those simulated by QCT-based FE analyses of T8. We hypothesized that the FE predictions would be more accurate when the boundary conditions are based on measurements of pressure distributions within intervertebral discs of similar level of disc degeneration vs. boundary conditions representing rigid platens. The FE simulations captured some of the general, qualitative features of the failure patterns; however, displacement errors ranged 12-279%. Contrary to our hypothesis, no differences in displacement errors were found when using boundary conditions representing measurements of disc pressure vs. rigid platens. The smallest displacement errors were obtained using boundary conditions that were measured directly by DVC at the T8 endplates. These findings indicate that further work is needed to develop methods of identifying physiological loading conditions for the vertebral body, for the purpose of achieving robust, patient-specific FE analyses of failure mechanisms.
authors.affiliation: Department of Biomedical Engineering, Boston University, Boston, MA, United States.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Jackman
authors.affiliation: Department of Biomedical Engineering, Boston University, Boston, MA, United States; Department of Mechanical Engineering, Boston University, Boston, MA, United States.
authors.forename: Alex M
authors.initials: AM
authors.lastname: DelMonaco
authors.affiliation: Department of Biomedical Engineering, Boston University, Boston, MA, United States; Department of Mechanical Engineering, Boston University, Boston, MA, United States. Electronic address: efmorgan@bu.edu.
authors.forename: Elise F
authors.initials: EF
authors.lastname: Morgan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D019245:Compressive Strength; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D007403:Intervertebral Disc / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D016103:Spinal Fractures / Q000000981:diagnostic imaging*; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D055114:X-Ray Microtomography
keywords: Digital volume correlation; Finite element analysis; Intervertebral disc; Quantitative computed tomography; Vertebral fracture