title: Numerical evaluation of bone remodelling associated with trans-femoral osseointegration implant--A 68 month follow-up study.
abstract: Osseointegrated trans-femoral implant is a relatively new orthopaedic anchoring method for connecting a stump with a prosthesis. Through a follow-up study of a patient over six years, significant bone remodelling has been observed. Finite element (FE) simulations were carried out to investigate the relationship between the bone remodelling and the strain re-distribution around the trans-femoral osseointegrated implant system. An initial FE model representing the original status of the femur-implant assembly was created from CT scans of the subject prior to osseointegration. Follow-up X-ray images were acquired at various stages post-surgery, which allowed the changes in bone wall thickness to be measured. By updating the bone thickness in the initial model, a series of follow-up FE models were created. Representative load associated with the subject's body weight was applied to the models, and the strain re-distributions were calculated. The results showed that in order to minimise the adverse effect of bone remodelling, an osseointegration implant made by functionally gradient materials are preferred over homogeneous materials.
authors.affiliation: Department of Orthopaedics, The First Central Hospital of Tianjin, N24 Fu Kang Road, NanKai District, Tianjin 300192, China.
authors.forename: D H
authors.initials: DH
authors.lastname: Xu
authors.affiliation: Department of Mechanical Engineering Sciences University of Surrey, Guildford, Surrey GU2 7XH, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Crocombe
authors.affiliation: Department of Mechanical Engineering Sciences University of Surrey, Guildford, Surrey GU2 7XH, UK. Electronic address: w.xu@surrey.ac.uk.
authors.forename: W
authors.initials: W
authors.lastname: Xu
mesh_terms: D016880:Anisotropy; D001186:Artificial Limbs; D016723:Bone Remodeling; D003198:Computer Simulation; D005269:Femur / Q000000981:diagnostic imaging / Q000601:surgery*; D020342:Finite Element Analysis; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D016348:Osseointegration / Q000502:physiology*; D011312:Pressure; D012984:Software; D013314:Stress, Mechanical; D014057:Tomography, X-Ray Computed; D014965:X-Rays
keywords: Bone remodelling; Femur; Finite element analysis; Implant; Osseointegration