title: Inflammaging and cardiovascular disease: Management by medicinal plants.
abstract: BACKGROUND
  In aging, a host of molecular and cellular changes occur which accelerate alteration and progression of inflammatory diseases. These conditions in the elderly people cause appearance of a phenomenon which has been denoted as "inflammaging". Understanding the pathogenesis and finding new methods for management of inflammaging are essential.
  
  
  OBJECTIVE
  In this paper we tried not only to explain inflammaging and its treatments with concentrating on medical plants but to collect a sufficient collection of anti-inflammatory plants with focusing on their mechanism of action.
  
  
  METHODS
  In this review paper, by searching in indexing cites, desired articles were obtained since 1995 by using keywords of inflammation, inflammaging, inflammation pathophysiology, free radicals and inflammation, aging inflammation, inflammatory disease, and plants or herbal medicine in inflammation.
  In advanced age the generation of free radicals increases in cardiovascular system. Pathological inflammation is also associated with production of excess free radicals More importantly, chronic inflammation makes aged people susceptible to age-related diseases. Some medicinal plants have been shown promising results in inhibition of inflammaging. Some other sections such as inflammation and inflammaging in cardiovascular diseases, oxidative stress in cardiovascular complications, prevention and treatment strategies are presented.
  
  
  CONCLUSIONS
  The results of published papers show that the symptoms of several inflammatory diseases can be inhibited or treated by active ingredients from medicinal plants.
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Erfaneh
authors.initials: E
authors.lastname: Shayganni
authors.affiliation: Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Bahmani
authors.affiliation: Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Asgary
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address: rafieian@yahoo.com.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Rafieian-Kopaei
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology* / Q000517:prevention & control; D018384:Oxidative Stress / Q000187:drug effects; D010946:Plants, Medicinal
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants
keywords: Aging; Anti-inflammatory drugs; Cardiovascular disease; Inflammaging; Inflammation; Medicinal plants