title: [Two Cases of Curative Resection of Locally Advanced Rectal Cancer after Preoperative Chemotherapy].
abstract: Reports of conversion in cases of locally advanced colorectal cancer have been increasing. Here, we present 2 cases in which curative resection of locally advanced rectal cancer accompanied by intestinal obstruction was achieved after establishing a stoma and administering chemotherapy. The first case was of a 46-year-old male patient diagnosed with upper rectal cancer and intestinal obstruction. Because of a high level of retroperitoneal invasion, after establishing a sigmoid colostomy, 13 courses of mFOLFOX6 plus Pmab were administered. Around 6 months after the initial surgery, low anterior resection for rectal cancer and surgery to close the stoma were performed. Fourteen days after curative resection, the patient was discharged from the hospital. The second case was of a 66-year-old male patient with a circumferential tumor extending from Rs to R, accompanied by right ureter infiltration and sub-intestinal obstruction. After establishing a sigmoid colostomy, 11 courses of mFOLFOX6 plus Pmab were administered. Five months after the initial surgery, anterior resection of the rectum and surgery to close the stoma were performed. Twenty days after curative resection, the patient was released from the hospital. No recurrences have been detected in either case.
authors.affiliation: Dept. of Gastroenterology and Surgery, Narashino-Daiichi Hospital.
authors.forename: Noboru
authors.initials: N
authors.lastname: Mitsuhashi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuboki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Yoshitomi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kato
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohtsuka
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Masaru
authors.initials: M
authors.lastname: Miyazaki
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000031:analogs & derivatives; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D054047:Surgical Stomas
chemical_list: D009944:Organoplatinum Compounds; C053813:4-(N-((2,4-diamino-6-pteridinyl)methyl)amino)benzoic acid; D002955:Leucovorin; D005472:Fluorouracil; D008727:Methotrexate