title: MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs).
abstract: Infection by mouse papillomavirus (PV), MmuPV1, of T cell-deficient, B6.Cg-Foxn1(nu)/J nude mice revealed that four, distinct squamous papilloma phenotypes developed simultaneously after infection of experimental mice. Papillomas appeared on the muzzle, vagina, and tail at or about day 42days post-inoculation. The dorsal skin developed papillomas and hair follicle tumors (trichoblastomas) as early as 26days after infection. Passive transfer of hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs) to T cell-deficient strains of mice prevented infection by virions of experimental mice. This study provides further evidence that T cell deficiency is critical for tumor formation by MmuPV1 infection.
authors.affiliation: James Graham Brown Cancer Center, 505 South Hancock Street, Louisville, KY, United States; Department of Medicine, 550 South Jackson Street, Louisville, KY, United States. Electronic address: j0joh001@louisville.edu.
authors.forename: Joongho
authors.initials: J
authors.lastname: Joh
authors.affiliation: James Graham Brown Cancer Center, 505 South Hancock Street, Louisville, KY, United States.
authors.forename: Shin-je
authors.initials: SJ
authors.lastname: Ghim
authors.affiliation: Christine M. Kleinert Institute for Hand & Microsurgery, 225 Abraham Flexner Way, Suite 850, Louisville, KY, United States.
authors.forename: Paula M
authors.initials: PM
authors.lastname: Chilton
authors.affiliation: The Jackson Laboratory, Bar Harbor, ME, United States.
authors.forename: John P
authors.initials: JP
authors.lastname: Sundberg
authors.affiliation: James Graham Brown Cancer Center, 505 South Hancock Street, Louisville, KY, United States.
authors.forename: Jino
authors.initials: J
authors.lastname: Park
authors.affiliation: Research Resources Center, 530 South Jackson Street, Louisville, KY, United States.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Wilcher
authors.affiliation: Research Resources Center, 530 South Jackson Street, Louisville, KY, United States.
authors.forename: Mary L
authors.initials: ML
authors.lastname: Proctor
authors.affiliation: James Graham Brown Cancer Center, 505 South Hancock Street, Louisville, KY, United States.
authors.forename: A
authors.initials: A
authors.lastname: Bennett Jenson
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D020297:Mice, Congenic; D008819:Mice, Nude; D008822:Mice, Transgenic; D010212:Papilloma / Q000821:virology*; D030361:Papillomavirus Infections / Q000821:virology*; D012878:Skin Neoplasms / Q000473:pathology / Q000821:virology*; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology*; D014771:Virion / Q000378:metabolism*
keywords: L1 proteins; Mouse papillomavirus (MmuPV1); PV induced tumorigenesis; Passive transfusion of hyperimmune sera; Virus neutralization