title: Association of IREB2 Gene rs2568494 Polymorphism with Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis.
abstract: BACKGROUND
  It is reported that the iron-responsive element-binding protein 2 (IREB2) gene rs2568494 polymorphism might be associated with COPD risk. The purpose of this meta-analysis was to collect all eligible studies to review the association between IREB2 gene rs2568494 polymorphism and susceptibility to COPD.
  
  
  METHODS
  We carried out a comprehensive document search of electronic databases of PubMed, MEDLIN, Web of Science, and included 4 eligible studies that examined the association between IREB2 rs2568494 polymorphism and COPD susceptibility. We performed a meta-analysis of these studies based on IREB2 rs2568494 genotypes.
  
  
  RESULTS
  After meta-analysis with fixed or random effects, no significant associations were found under the heterozygote model (GG/GA; OR=0.908, 95%CI: 0.790-1.043; P=0.172), homozygote model (GG/AA; OR=0.880, 95%CI: 0.497-1.557; P=0.661), dominant model (GG/AA+GA; OR=0.941, 95%CI: 0.748-1.182; P=0.599), or allelic model (G/A; OR=0.953, 95%CI: 0.770-1.179; P=0.655). However, we found a significant correlation under the recessive model (AA/GA+GG; OR=1.384, 95%CI: 1.092-1.755; P=0.007).
  
  
  CONCLUSIONS
  The current results revealed that there was significant association between IREB2 gene rs2568494 polymorphism with susceptibility to COPD; the presence of allelic A might a genetic factor conferring susceptibility to COPD.
authors.affiliation: Department of Health Care, Qianfoshan Hospital, Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Yiming
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D035942:Iron Regulatory Protein 2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D012307:Risk Factors
chemical_list: D035942:Iron Regulatory Protein 2