title: SENSI: signal enhancement by spectral integration for the analysis of metabolic mixtures.
abstract: The method provided here can overcome the low S/N problem in (13)C NMR, by the integration of plural spectra to take advantage of high-resolution potential based on non-bucketing analysis without additional measurements. In addition, a new metabolite annotation approach using advanced STOCSY and quantum chemistry calculations was introduced in this study.
authors.affiliation: Graduate School of Medical Life Science, Yokohama City University (YCU), 1-7-29 Suehirocho, Tsurumi-ku, Yokohama 230-0045, Japan and RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 235-0045, Japan. jun.kikuchi@riken.jp.
authors.forename: Takuma
authors.initials: T
authors.lastname: Misawa
authors.affiliation: Graduate School of Medical Life Science, Yokohama City University (YCU), 1-7-29 Suehirocho, Tsurumi-ku, Yokohama 230-0045, Japan and RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 235-0045, Japan. jun.kikuchi@riken.jp.
authors.forename: Takanori
authors.initials: T
authors.lastname: Komatsu
authors.affiliation: Graduate School of Medical Life Science, Yokohama City University (YCU), 1-7-29 Suehirocho, Tsurumi-ku, Yokohama 230-0045, Japan and RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 235-0045, Japan. jun.kikuchi@riken.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Date
authors.affiliation: Graduate School of Medical Life Science, Yokohama City University (YCU), 1-7-29 Suehirocho, Tsurumi-ku, Yokohama 230-0045, Japan and RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 235-0045, Japan. jun.kikuchi@riken.jp and Graduate School of Bioagricultural Sciences and School of Agricultural Sciences, Nagoya University, 1 Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kikuchi
mesh_terms: D066241:Carbon-13 Magnetic Resonance Spectroscopy / Q000379:methods*; D008660:Metabolism