title: [Negative symptoms in schizophrenia: psychotherapeutic approaches].
abstract: Although negative symptoms are recognized as a central feature of schizophrenia, their definition as well as phenomenology have long been a vexing issue. During these last years, a major progress has been made with the delineation of two underlying subdomains of negative symptoms: diminished expression and anhedonia-avolition-apathy. As current guidelines are not always in accord on the efficacy of treatments on negative symptoms, it may be tempting to re-interpret the findings of clinical trials by looking at the effects of treatments on these two subdomains. This could concern both psychotropic treatments and psychotherapeutic interventions. Furthermore, neuroimaging as well as emotional response studies have permitted to better understand the mechanism which could be at the root of diminished expression and anhedonia in schizophrenia. On this basis, new psychotherapeutic methods have been devised which, by specifically targeting these two subdomains, are likely to be more efficient on negative symptoms. Further research is warranted to test their efficacy in randomized controlled trials.
authors.affiliation: SHU Psychiatrie adultes, Hôpital Ste Marguerite, 13274 Marseille cedex 9, France. Electronic address: jazorin@ap-hm.fr.
authors.forename: J-M
authors.initials: JM
authors.lastname: Azorin
authors.affiliation: SHU Psychiatrie adultes, Hôpital Ste Marguerite, 13274 Marseille cedex 9, France.
authors.forename: M
authors.initials: M
authors.lastname: Adida
authors.affiliation: SHU Psychiatrie adultes, Hôpital Ste Marguerite, 13274 Marseille cedex 9, France.
authors.forename: R
authors.initials: R
authors.lastname: Belzeaux
authors.affiliation: Faculté de Médecine de Nice - UNSA - 28 avenue de Vallombrose, 06107 Nice, France.
authors.forename: D
authors.initials: D
authors.lastname: Pringuey
authors.affiliation: Service d'exploration fonctionnelle du système nerveux. Clinique du sommeil. CHU de Bordeaux, Place Amélie Raba-Léon, 33076 Bordeaux et USR CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, Bordeaux cedex, France.
authors.forename: J-A
authors.initials: JA
authors.lastname: Micoulaud Franchi
authors.affiliation: Service de Pharmacologie Clinique, CAP-TV, Hôpital Ste Marguerite, 13274 Marseille cedex 9, France.
authors.forename: N
authors.initials: N
authors.lastname: Simon
authors.affiliation: SHU Psychiatrie adultes, Hôpital Ste Marguerite, 13274 Marseille cedex 9, France.
authors.forename: M
authors.initials: M
authors.lastname: Cermolacce
authors.affiliation: Service de Psychiatrie adultes, CHU Robert Debré, Avenue du Général Koenig, 51092 Reims cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Kaladjian
authors.affiliation: Service de Psychiatrie adultes, CHU Saint-Étienne, 5 Chemin de la Marandière, 42055 Saint-Étienne cedex 2, France.
authors.forename: E
authors.initials: E
authors.lastname: Fakra
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D011613:Psychotherapy / Q000379:methods*; D012559:Schizophrenia / Q000188:drug therapy / Q000628:therapy*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents
keywords: Anhedonia; Anhédonie; Apathie; Apathy; Avolition; Negative symptoms; Psychotherapy; Psychothérapie; Symptômes négatifs