title: Evaluation of powder, solution and suspension layering for the preparation of enteric coated pellets.
abstract: Gastro-resistant pellets were prepared by use of three different drug loading techniques (powder layering, solution layering and suspension layering) and two different enteric coating techniques (powder layering and suspension layering). Pellets produced by different layering techniques were compared in terms of morphological characteristics, content of drug, release properties and stability. Drug loaded pellets produced by the use of powder layering had much more pronounced surface roughness in comparison to other tested techniques. Higher weight gains of enteric polymer were needed to achieve the same level of gastric resistance when powder layering was employed to apply enteric layer than when it was applied by suspension layering. Both tested techniques of enteric coating application enabled complete dissolution of drug in buffer stage of dissolution test. Suspension layering proved to be superior to other techniques both in drug loading and enteric layering phase.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Belgrade, Serbia.
authors.forename: Jovana
authors.initials: J
authors.lastname: Kovacevic
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Belgrade, Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Mladenovic
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Djuris
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Belgrade, Serbia. Electronic address: svetlana.ibric@pharmacy.bg.ac.rs.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ibric
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D004339:Drug Compounding / Q000379:methods; D004343:Drug Implants / Q000737:chemistry*; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011208:Powders / Q000737:chemistry*; D012995:Solubility; D012996:Solutions / Q000737:chemistry*; D013535:Suspensions / Q000737:chemistry*; D013608:Tablets, Enteric-Coated / Q000737:chemistry*
chemical_list: D004343:Drug Implants; D005079:Excipients; D011108:Polymers; D011208:Powders; D012996:Solutions; D013535:Suspensions; D013608:Tablets, Enteric-Coated
keywords: Dissolution; Drug layering; Enteric coating; Pellets; Stability