title: [Correlation between neonatal vitamin D level and maternal vitamin D level].
abstract: OBJECTIVE
  To investigate the correlation between neonatal and maternal vitamin D levels.
  
  
  METHODS
  From June 1 to July 10, 2015, umbilical venous blood samples were collected from 102 full-term single neonates, and venous blood samples were collected from their mothers. Ultra-performance liquid chromatography with isotope dilution was applied to measure the serum 25(OH)D level.
  
  
  RESULTS
  Vitamin D insufficiency was found in 39 mothers (38.2%) and 27 neonates (26.5%), and vitamin D deficiency was found in 25 mothers (24.5%) and 66 neonates (64.7%). Neonatal serum 25(OH)D level differed significantly between the groups of mothers with different serum 25(OH)D levels (P<0.001). Maternal 25(OH)D level was positively correlated with neonatal vitamin D level (r=0.914, P<0.001). When the receiver operating characteristic curve for maternal 25(OH)D level was used to predict neonatal vitamin D deficiency (≤15 ng/mL), the area under the curve was 0.962 (95%CI: 0.930-0.994; P<0.001). The sensitivity and specificity of maternal serum 25(OH)D level≤27.55 ng/mL to predict neonatal vitamin D deficiency were 97.2% and 80.3%, respectively.
  
  
  CONCLUSIONS
  Neonatal vitamin D level is positively correlated with maternal vitamin D level. Maternal vitamin D level can help to predict neonatal vitamin D deficiency.
authors.affiliation: Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. danhuawang10@126.com.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Gao
authors.forename: Song-Lin
authors.initials: SL
authors.lastname: Yu
authors.forename: Ling
authors.initials: L
authors.lastname: Qiu
authors.forename: Lin
authors.initials: L
authors.lastname: Zeng
authors.forename: Dan-Hua
authors.initials: DH
authors.lastname: Wang
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy / Q000097:blood*; D012372:ROC Curve; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000175:diagnosis
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D