title: Strongly Accelerated Margination of Active Particles in Blood Flow.
abstract: Synthetic nanoparticles and other stiff objects injected into a blood vessel filled with red blood cells are known to marginate toward the vessel walls. By means of hydrodynamic lattice-Boltzmann simulations, we show that active particles can strongly accelerate their margination by moving against the flow direction: particles located initially in the channel center migrate much faster to their final position near the wall than in the nonactive case. We explain our findings by an enhanced rate of collisions between the stiff particles and the deformable red blood cells. Our results imply that a significantly faster margination can be achieved either technically by the application of an external magnetic field (if the particles are magnetic) or biologically by self-propulsion (if the particles are, e.g., swimming bacteria).
authors.affiliation: Physikalisches Institut, Universität Bayreuth, Bayreuth, Germany. Electronic address: stephan.gekle@uni-bayreuth.de.
authors.forename: Stephan
authors.initials: S
authors.lastname: Gekle
mesh_terms: D004912:Erythrocytes / Q000502:physiology; D018056:Hemorheology; D057446:Hydrodynamics; D060526:Magnetic Fields; D008962:Models, Theoretical; D009038:Motion; D053758:Nanoparticles / Q000008:administration & dosage / Q000009:adverse effects*