title: In situ deposition of a personalized nanofibrous dressing via a handy electrospinning device for skin wound care.
abstract: Current strategies for wound care provide limited relief to millions of patients who suffer from burns, chronic skin ulcers or surgical-related wounds. The goal of this work is to develop an in situ deposition of a personalized nanofibrous dressing via a handy electrospinning (e-spinning) device and evaluate its properties related to skin wound care. MCM-41 type mesoporous silica nanoparticles decorated with silver nanoparticles (Ag-MSNs) were prepared by a facile and environmentally friendly approach, which possessed long-term antibacterial activity and low cytotoxicity. Poly-ε-caprolactone (PCL) incorporated with Ag-MSNs was successfully electrospun (e-spun) into nanofibrous membranes. These in situ e-spun nanofibrous membranes allowed the continuous release of Ag ions and showed broad-spectrum antimicrobial activity against two common types of pathogens, Staphylococcus aureus and Escherichia coli. In addition, the in vivo studies revealed that these antibacterial nanofibrous membranes could reduce the inflammatory response and accelerate wound healing in Wistar rats. The above results strongly demonstrate that such patient-specific dressings could be broadly applied in emergency medical transport, hospitals, clinics and at the patients' home in the near future.
authors.affiliation: Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, P. R. China. yunze.long@163.com yunze.long@qdu.edu.cn.
authors.forename: Rui-Hua
authors.initials: RH
authors.lastname: Dong
authors.forename: Yue-Xiao
authors.initials: YX
authors.lastname: Jia
authors.forename: Chong-Chong
authors.initials: CC
authors.lastname: Qin
authors.forename: Lu
authors.initials: L
authors.lastname: Zhan
authors.forename: Xu
authors.initials: X
authors.lastname: Yan
authors.forename: Lin
authors.initials: L
authors.lastname: Cui
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xingyu
authors.initials: X
authors.lastname: Jiang
authors.forename: Yun-Ze
authors.initials: YZ
authors.lastname: Long
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001458:Bandages; D004926:Escherichia coli / Q000737:chemistry; D008297:Male; D008567:Membranes, Artificial; D053768:Metal Nanoparticles / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000254:growth & development; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D008567:Membranes, Artificial; D012834:Silver