title: Prevalence of Serum IgG Antibodies to Cystic Echinococcus Antigen among Patients in an Uzbekistan Emergency Hospital.
abstract: Cystic echinococcosis (CE) is one of the most widespread zoonotic helminthiases, which can last an asymptomatic infection for several years. The purpose of this study was to demonstrate serum antibody prevalence of CE among asymptomatic people in Uzbekistan using ELISA. A total of 2,547 serum samples were collected, 66 from confirmed CE patients and 2,481 of patients with other diseases than CE at a hospital in Tashkent, Uzbekistan. The serum samples were screened for CE specific IgG antibodies by ELISA using cystic fluid antigen obtained from sheep. The serum antibody positive rate was 89.4% (59/66) in CE and 3.6% (89/2,481) in other disease patients. The present ELISA recognized 89.4% sensitivity and 96.4% specificity. The ELISA absorbance of positive samples was distributed 0.271-0.971 for CE and 0.273-0.887 for other disease patients. The other disease patients with high absorbance over 0.3 were 50 (2.0%) who were presumed to be active CE patients. The patients in their 40s showed the highest positive rate of 5.2% (P=0.181), and women were 4.4% while men were 3.1% positive (P=0.136). The data confirmed that there are many asymptomatic patients of CE in Tashkent. It is indicated that CE is an endemic disease of public health importance in Uzbekistan.
authors.affiliation: School of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: School of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
authors.forename: Sung Sik
authors.initials: SS
authors.lastname: Han
authors.affiliation: Department of Surgery, Republican Research Center for Emergency Medicine, Tashkent 100107, Uzbekistan.
authors.forename: Khikmat
authors.initials: K
authors.lastname: Anvarov
authors.affiliation: Department of Surgery, Republican Research Center for Emergency Medicine, Tashkent 100107, Uzbekistan.
authors.forename: Abdukhakim
authors.initials: A
authors.lastname: Khajibaev
authors.affiliation: Department of Parasitology and Tropical Medicine, Institute of Endemic Diseases, Seoul National University, College of Medicine, Seoul 03080, Korea.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Choi
authors.affiliation: Department of Parasitology and Tropical Medicine, Institute of Endemic Diseases, Seoul National University, College of Medicine, Seoul 03080, Korea.
authors.forename: Sung-Tae
authors.initials: ST
authors.lastname: Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004443:Echinococcosis / Q000097:blood* / Q000453:epidemiology / Q000469:parasitology; D004446:Echinococcus / Q000276:immunology* / Q000302:isolation & purification; D004636:Emergency Service, Hospital; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014610:Uzbekistan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000909:Antibodies, Helminth; D007074:Immunoglobulin G
keywords: ELISA; Echinococcus granulosus; Uzbekistan; asymptomatic patient; cystic echinococcosis; positive rate; serum antibody