title: A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin".
abstract: Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body's different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin" under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.
authors.affiliation: Clinical Nutrition Department, Nutrition Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Jalili
authors.affiliation: Medical Biotechnology Department, Medicine Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Bazi
authors.affiliation: Clinical Nutrition Department, Nutrition Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Azita
authors.initials: A
authors.lastname: Hekmatdoost
mesh_terms: D005353:Fibronectins / Q000235:genetics*; D045683:Furin / Q000235:genetics*; D015316:Genetic Therapy; D006801:Humans; D009765:Obesity / Q000628:therapy*; D010843:Pichia / Q000235:genetics*; D011993:Recombinant Fusion Proteins / Q000235:genetics*; D014168:Transferrin / Q000235:genetics*; D015431:Weight Loss
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins; D011993:Recombinant Fusion Proteins; D014168:Transferrin; C468731:FURIN protein, human; D045683:Furin