title: [A Case of Stage Ⅳ Rectal Cancer with No Evidence of Disease after Neoadjuvant Chemotherapy and Surgery].
abstract: A 46-year-old man presented with hematochezia in October 2012. A circumferential type 2 rectal cancer was detected with colonoscopy. Contrast-enhanced CT showed multiple liver and lung metastases. Chemotherapy was administered after the diagnosis of cStage Ⅳ rectal cancer. After 1 course of XELOX plus Bmab, the treatment was changed to XELOX plus Cmab for 21 courses. An infusion reaction occurred during the 21st course. Because a complete response of the liver metastases and a reduction in size of the primary tumor had been achieved, we performed a low anterior resection in April 2014. The final pathological diagnosis was type 2, 10×25 mm, tub1, pMP, int, INF b, pN1 (251). There was no evidence of disease (NED) after the surgery. We are closely following up this patient with no postoperative chemotherapy, and as of July 2015, there is no sign of recurrence. We describe a case of a Stage Ⅳ rectal cancer that was resected with radical surgery after neoadjuvant chemotherapy. We also include a brief review of the literature.
authors.affiliation: Dept. of Surgery, Tojun Hospital.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Watanabe
authors.forename: Megumi
authors.initials: M
authors.lastname: Sasaki
authors.forename: Yukari
authors.initials: Y
authors.lastname: Shibasaki
authors.forename: Koji
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Aoyagi
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Higuchi
authors.forename: Keita
authors.initials: K
authors.lastname: Koseki
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Kitago
authors.forename: Naoto
authors.initials: N
authors.lastname: Nishi
authors.forename: Zenro
authors.initials: Z
authors.lastname: Nihei
authors.forename: Masashi
authors.initials: M
authors.lastname: Ito
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome