title: Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis.
abstract: It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort studies were quantitatively analyzed to evaluate IL-10 promoter gene polymorphisms and NPC risk. Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated for each genetic model and allelic comparison. A random-effect model or a fixed-effect model was used to calculate the overall combined risk estimates. Overall, the variant genotypes (AA and AG) of the IL-10-1082 A/G polymorphism were associated with elevated risk of NPC compared with the GG homozygote (AG vs GG: OR = 1.77; 95%CI = 1.39-2.26; AG + GG vs AA: OR = 1.78; 95%CI = 1.42-2.22); no significant associations were observed in allelic contrast and the recessive model. Strong positive association was seen in the cohort studies but not in the case-control studies. No statistically significant association was detected between IL-10-819 T/C and IL-10-592 A/C polymorphisms and NPC. Additionally, publication bias was not found. Based on the current evidence, this meta-analysis suggests that IL-1082 A/G polymorphism may increase the risk of NPC, but IL-10-819 T/C and IL-10-592 A/C polymorphisms do not. Further multicenter studies that are better controlled are required to confirm these findings.
authors.affiliation: Department of Radiology, The First People's Hospital of Shunde, Foshan, Guangdong, China.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Yu
authors.affiliation: Ear Nose and Throat Diagnosis and Treatment Center, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, China.
authors.forename: Z-G
authors.initials: ZG
authors.lastname: Han
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, China.|Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors.forename: W-B
authors.initials: WB
authors.lastname: Guo
authors.affiliation: Ear Nose and Throat Diagnosis and Treatment Center, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, China.
authors.forename: G-J
authors.initials: GJ
authors.lastname: Zhang
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: J-K
authors.initials: JK
authors.lastname: Yang
authors.affiliation: Department of Stomatology, The Twelfth People's Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: F-L
authors.initials: FL
authors.lastname: Wu
authors.affiliation: Department of Ultrasound, The First People's Hospital of Shunde, Foshan, Guangdong, China.
authors.forename: Q-Y
authors.initials: QY
authors.lastname: Ou
authors.affiliation: Department of Otolaryngology, Jinan University, Guangzhou Overseas Chinese Hospital, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
authors.forename: Y-H
authors.initials: YH
authors.lastname: Li
authors.affiliation: Department of Biomedicine, Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: X-Y
authors.initials: XY
authors.lastname: Cai
authors.affiliation: Ear Nose and Throat Diagnosis and Treatment Center, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, China.
authors.forename: Z-N
authors.initials: ZN
authors.lastname: Zhan
authors.affiliation: Department of Stomatology, The Twelfth People's Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: J-H
authors.initials: JH
authors.lastname: Chen
authors.affiliation: Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors.forename: W-L
authors.initials: WL
authors.lastname: Xie
authors.affiliation: Ear Nose and Throat Diagnosis and Treatment Center, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, China.
authors.forename: L
authors.initials: L
authors.lastname: Tang
authors.affiliation: Ear Nose and Throat Diagnosis and Treatment Center, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, China.
authors.forename: C-D
authors.initials: CD
authors.lastname: Liu
mesh_terms: D002277:Carcinoma; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10