title: Baroreflex dysfunction in chronic kidney disease.
abstract: Chronic kidney disease (CKD) patients have high cardiovascular mortality and morbidity. The presence of traditional and CKD related risk factors results in exaggerated vascular calcification in these patients. Vascular calcification is associated with reduced large arterial compliance and thus impaired baroreflex sensitivity (BRS) resulting in augmented blood pressure (BP) variability and hampered BP regulation. Baroreflex plays a vital role in short term regulation of BP. This review discusses the normal baroreflex physiology, methods to assess baroreflex function, its determinants along with the prognostic significance of assessing BRS in CKD patients, available literature on BRS in CKD patients and the probable patho-physiology of baroreflex dysfunction in CKD.
authors.affiliation: Manpreet Kaur, Dinu S Chandran, Ashok Kumar Jaryal, Kishore Kumar Deepak, Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Manpreet
authors.initials: M
authors.lastname: Kaur
authors.affiliation: Manpreet Kaur, Dinu S Chandran, Ashok Kumar Jaryal, Kishore Kumar Deepak, Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Dinu S
authors.initials: DS
authors.lastname: Chandran
authors.affiliation: Manpreet Kaur, Dinu S Chandran, Ashok Kumar Jaryal, Kishore Kumar Deepak, Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Jaryal
authors.affiliation: Manpreet Kaur, Dinu S Chandran, Ashok Kumar Jaryal, Kishore Kumar Deepak, Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Bhowmik
authors.affiliation: Manpreet Kaur, Dinu S Chandran, Ashok Kumar Jaryal, Kishore Kumar Deepak, Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Sanjay Kumar
authors.initials: SK
authors.lastname: Agarwal
authors.affiliation: Manpreet Kaur, Dinu S Chandran, Ashok Kumar Jaryal, Kishore Kumar Deepak, Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Kishore Kumar
authors.initials: KK
authors.lastname: Deepak
keywords: Baroreflex sensitivity; Blood pressure variability; Chronic kidney disease; Large arterial compliance; Vascular calcification