title: Reprogramming the T Cell Response to Tuberculosis.
abstract: Coscolla, Copin et al. recently used comparative genomics of M. tuberculosis (Mtb) strains to show that most human T cell-recognized epitopes are hyperconserved, but bona fide variable epitopes also exist. This identification of two sets of antigens implies opposing evolutionary processes and will have an important impact on tuberculosis (TB) vaccine strategy and design.
authors.affiliation: Statens Serum Institut, Department of Infectious Disease Immunology, Artillerivej 5, 2300 Copenhagen S, Denmark.
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Woodworth
authors.affiliation: Statens Serum Institut, Department of Infectious Disease Immunology, Artillerivej 5, 2300 Copenhagen S, Denmark. Electronic address: pa@ssi.dk.
authors.forename: Peter
authors.initials: P
authors.lastname: Andersen
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology; D000939:Epitopes; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology*; D032581:Tuberculosis Vaccines / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D000939:Epitopes; D032581:Tuberculosis Vaccines