title: In Vivo Validation of a 3-D Ultrasound System for Imaging the Lateral Ventricles of Neonates.
abstract: Intra-ventricular hemorrhage, with the resultant cerebral ventricle dilation, is a common cause of brain injury in preterm neonates. Clinically, monitoring is performed using 2-D ultrasound (US); however, its clinical utility in dilation is limited because it cannot provide accurate measurements of irregular volumes such as those of the ventricles, and this might delay treatment until the patient's condition deteriorates severely. We have developed a 3-D US system to image the lateral ventricles of neonates within the confines of incubators. We describe an in vivo ventricle volume validation study in two parts: (i) comparisons between ventricle volumes derived from 3-D US and magnetic resonance images obtained within 24 h; and (ii) the difference between 3-D US ventricle volumes before and after clinically necessary interventions (ventricle taps), which remove cerebral spinal fluid. Magnetic resonance imaging ventricle volumes were found to be 13% greater than 3-D US ventricle volumes; however, we observed high correlations (R(2) = 0.99) when comparing the two modalities. Differences in ventricle volume pre- and post-intervention compared with the reported volume of cerebrospinal fluid removed also were highly correlated (R(2) = 0.93); the slope was not found to be statistically significantly different from 1 (p < 0.05), and the y-intercept was not found to be statistically different from 0 (p < 0.05). Comparison between 3-D US images can detect the volume change after neonatal intra-ventricular hemorrhage. This could be used to determine which patients will have progressive ventricle dilation and allow for more timely surgical interventions. However, 3-D US ventricle volumes should not be directly compared with magnetic resonance imaging ventricle volumes.
authors.affiliation: Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; Robarts Imaging, University of Western Ontario, London, Ontario, Canada. Electronic address: jkishimo@uwo.ca.
authors.forename: Jessica
authors.initials: J
authors.lastname: Kishimoto
authors.affiliation: Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; Robarts Imaging, University of Western Ontario, London, Ontario, Canada.
authors.forename: Aaron
authors.initials: A
authors.lastname: Fenster
authors.affiliation: Department of Paediatrics, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada.
authors.forename: David S C
authors.initials: DS
authors.lastname: Lee
authors.affiliation: Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; Department of Paediatrics, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada; Department of Clinical Neurological Sciences, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada.
authors.forename: Sandrine
authors.initials: S
authors.lastname: de Ribaupierre
mesh_terms: D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000295:instrumentation* / Q000379:methods; D066298:In Vitro Techniques; D007231:Infant, Newborn; D020547:Lateral Ventricles / Q000000981:diagnostic imaging*; D008297:Male; D015997:Neonatal Screening / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000295:instrumentation* / Q000379:methods
keywords: 3-D ultrasound; Hydrocephalus; Intra-ventricular hemorrhage; Post-hemorrhagic ventricle dilation; Preterm neonate