title: Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by (129)Xe hyperCEST NMR.
abstract: We report a method for blocking interactions between (129)Xe and cucurbit[6]uril (CB6) until activation by a specific chemical event. We synthesized a CB6-rotaxane that allowed no (129)Xe interaction with the CB6 macrocycle component until a cleavage event released the CB6, which then produced a (129)Xe@CB6 NMR signal. This contrast-upon-activation (129)Xe NMR platform allows for modular synthesis and can be expanded to applications in detection and disease imaging.
authors.affiliation: Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
authors.forename: Joel A
authors.initials: JA
authors.lastname: Finbloom
authors.affiliation: Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA and Materials Sciences Division, Lawrence Berkeley National Laboratories, Berkeley, CA 94720, USA.
authors.forename: Clancy C
authors.initials: CC
authors.lastname: Slack
authors.affiliation: Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
authors.forename: Carson J
authors.initials: CJ
authors.lastname: Bruns
authors.affiliation: Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA and Materials Sciences Division, Lawrence Berkeley National Laboratories, Berkeley, CA 94720, USA.
authors.forename: Keunhong
authors.initials: K
authors.lastname: Jeong
authors.affiliation: Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720. mbfrancis@berkeley.edu.
authors.forename: David E
authors.initials: DE
authors.lastname: Wemmer
authors.affiliation: Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA and Materials Sciences Division, Lawrence Berkeley National Laboratories, Berkeley, CA 94720, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Pines
authors.affiliation: Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA and Materials Sciences Division, Lawrence Berkeley National Laboratories, Berkeley, CA 94720, USA.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Francis