title: [Two Cases of Colorectal Cancer with Tumor Thrombus in the Inferior Mesenteric Vein].
abstract: In colorectal cancer, progression with an intravenous tumor thrombus is very rare. Here, we report 2 cases of colorectal cancer which showed a tumor thrombus in the inferior mesenteric vein (IMV). Case 1: A 69-year-old woman was admitted for the treatment of advanced rectal cancer, and underwent a low anterior resection. Six months of post-operative therapy was carried out with mFOLFOX6, but a metachronous lung metastasis was detected and a lung partial resection was performed. Case 2: A 67-year-old man was admitted for the treatment of advanced sigmoid colon cancer with simultaneous liver metastasis, and underwent a laparoscopic high anterior resection. Four courses of mFOLFOX6+bevacizumab chemotherapy were carried out after surgery, and subsequently he underwent a partial hepatectomy. In both cases IMV tumor thrombus was suspected from abdominal contrast-enhanced computed tomography (CT). Tumor thrombus filling the lumen of the IMV was confirmed on histopathological examination. Colorectal cancer with IMV tumor thrombus is a form of advanced cancer with advanced vascular invasion, and there is a high risk of simultaneous or metachronous hematogenous metastasis. Combined modality therapy should therefore be given to improve the prognosis.
authors.affiliation: Dept. of Surgery, Osaka General Hospital of West Japan Railway Company.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Matsumura
authors.forename: Tomoya
authors.initials: T
authors.lastname: Hatakeyama
authors.forename: Shiro
authors.initials: S
authors.lastname: Ogino
authors.forename: Manabu
authors.initials: M
authors.lastname: Takemura
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Mugitani
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Akami
authors.forename: Shinji
authors.initials: S
authors.lastname: Okano
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ueda
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008642:Mesenteric Veins / Q000473:pathology*; D012004:Rectal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D012811:Sigmoid Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013927:Thrombosis / Q000209:etiology*