title: [A Case of Liver and Pulmonary Metastases from Adamantinoma, a Bone Tumor].
abstract: This case involved a 28-year-old man who had undergone surgery and perioperative chemotherapy for an adamantinoma of the right tibia with multiple lung metastases. Sixteen months after the initial diagnosis, CT revealed an 8 cm diameter liver metastasis and right pneumothorax with little change in the lung metastases. Liver resection and partial pneumonectomy were performed. Pathologic findings confirmed that both liver and lung specimens had metastases from the adamantinoma. Dissimilar from the primary lesion with much interstitial tissue and spindle-shaped cells, the liver metastasis had very dense cell proliferation without interstitial tissue and dominant epithelial parts, suggesting a higher malignant potential. If other lesions are under good control, resection of the newly appearing metastasis, which has a higher malignant potential, might improve prognosis. Further accumulation of cases and detailed studies is required.
authors.affiliation: Dept. of Gastroenterologic Surgery, Kanazawa University.
authors.forename: Toru
authors.initials: T
authors.lastname: Kurata
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Tajima
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Obatake
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakanuma
authors.forename: Isamu
authors.initials: I
authors.lastname: Makino
authors.forename: Hironori
authors.initials: H
authors.lastname: Hayashi
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Nakagawara
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Miyashita
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takamura
authors.forename: Sachio
authors.initials: S
authors.lastname: Fushida
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ota
mesh_terms: D050398:Adamantinoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008297:Male; D011013:Pneumonectomy; D016896:Treatment Outcome