title: Design, Development and Optimization of S (-) Atenolol Floating Sustained Release Matrix Tablets Using Surface Response Methodology.
abstract: The objective of this present investigation was to develop and formulate floating sustained release matrix tablets of s (-) atenolol, by using different polymer combinations and filler, to optimize by using surface response methodology for different drug release variables and to evaluate the drug release pattern of the optimized product. Floating sustained release matrix tablets of various combinations were prepared with cellulose-based polymers: Hydroxypropyl methylcellulose, sodium bicarbonate as a gas generating agent, polyvinyl pyrrolidone as a binder and lactose monohydrate as filler. The 3(2) full factorial design was employed to investigate the effect of formulation variables on different properties of tablets applicable to floating lag time, buoyancy time, % drug release in 1 and 6 h (D1 h,D6 h) and time required to 90% drug release (t90%). Significance of result was analyzed using analysis of non variance and P < 0.05 was considered statistically significant. S (-) atenolol floating sustained release matrix tablets followed the Higuchi drug release kinetics that indicates the release of drug follows anomalous (non-Fickian) diffusion mechanism. The developed floating sustained release matrix tablet of improved efficacy can perform therapeutically better than a conventional tablet.
authors.affiliation: Formulation and Development Department, Zuventus Healthcare Ltd, T-184 MIDC Bhosari, Pune-411 026, India.
authors.forename: P T
authors.initials: PT
authors.lastname: Gunjal
authors.affiliation: Formulation and Development Department, Zuventus Healthcare Ltd, T-184 MIDC Bhosari, Pune-411 026, India.
authors.forename: M B
authors.initials: MB
authors.lastname: Shinde
authors.affiliation: Emcure Pharmaceutical Ltd, Emcure House, Pune-411 026, India.
authors.forename: V S
authors.initials: VS
authors.lastname: Gharge
authors.affiliation: Emcure Pharmaceutical Ltd, Emcure House, Pune-411 026, India.
authors.forename: S V
authors.initials: SV
authors.lastname: Pimple
authors.affiliation: Emcure Pharmaceutical Ltd, Emcure House, Pune-411 026, India.
authors.forename: M K
authors.initials: MK
authors.lastname: Gurjar
authors.affiliation: Emcure Pharmaceutical Ltd, Emcure House, Pune-411 026, India.
authors.forename: M N
authors.initials: MN
authors.lastname: Shah
keywords: Buoyancy time; floating lag time; floating sustained release; hydrophilic polymers; s (-) atenolol; surface response methodology