title: Novel Anthraquinone-based Derivatives as Potent Inhibitors for Receptor Tyrosine Kinases.
abstract: The influence of new derivatives of 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity of membrane-associated tyrosine kinases was investigated. Inhibitors of protein tyrosine kinase activity of the membrane fraction, as promising agents to search for new potential anticancer agents among the studied compounds, were discovered.
authors.affiliation: Lviv Polytechnic National University, S. Bandera Street 12, Lviv-13, 79013, Ukraine.
authors.forename: M
authors.initials: M
authors.lastname: Stasevych
authors.affiliation: Lviv Polytechnic National University, S. Bandera Street 12, Lviv-13, 79013, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Zvarych
authors.affiliation: Lviv Polytechnic National University, S. Bandera Street 12, Lviv-13, 79013, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Lunin
authors.affiliation: Educational and Scientific Centre, Institute of Biology, Taras Shevchenko National University of Kyiv, Volodymyrska Street 64/13, Kyiv 01601, Ukraine.
authors.forename: T
authors.initials: T
authors.lastname: Halenova
authors.affiliation: Educational and Scientific Centre, Institute of Biology, Taras Shevchenko National University of Kyiv, Volodymyrska Street 64/13, Kyiv 01601, Ukraine.
authors.forename: O
authors.initials: O
authors.lastname: Savchuk
authors.affiliation: Lviv Polytechnic National University, S. Bandera Street 12, Lviv-13, 79013, Ukraine.
authors.forename: O
authors.initials: O
authors.lastname: Dudchak
authors.affiliation: Institute of Organic Chemistry of NASU, Murmanska Street 5, 02660 Kyiv-94, Ukraine.
authors.forename: M
authors.initials: M
authors.lastname: Vovk
authors.affiliation: Lviv Polytechnic National University, S. Bandera Street 12, Lviv-13, 79013, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Novikov
keywords: Anthraquinone; amino acid; protein tyrosine kinase activity; thiazole; thiourea; triazole