title: Knowing what and where: TMS evidence for the dual neural basis of geographical knowledge.
abstract: All animals acquire knowledge about the topography of their immediate environment through direct exploration. Uniquely, humans also acquire geographical knowledge indirectly through exposure to maps and verbal information, resulting in a rich database of global geographical knowledge. We used transcranial magnetic stimulation to investigate the structure and neural basis of this critical but poorly understood component of semantic knowledge. Participants completed tests of geographical knowledge that probed either information about spatial locations (e.g., France borders Spain) or non-spatial taxonomic information (e.g., France is a country). TMS applied to the anterior temporal lobe, a region that codes conceptual knowledge for words and objects, had a general disruptive effect on the geographical tasks. In contrast, stimulation of the intraparietal sulcus (IPS), a region involved in the coding of spatial and numerical information, had a highly selective effect on spatial geographical decisions but no effect on taxonomic judgements. Our results establish that geographical concepts lie at the intersection of two distinct neural representation systems, and provide insights into how the interaction of these systems shape our understanding of the world.
authors.affiliation: Neuroscience and Aphasia Research Unit (NARU), University of Manchester, UK; Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), Department of Psychology, University of Edinburgh, UK. Electronic address: p.hoffman@ed.ac.uk.
authors.forename: Paul
authors.initials: P
authors.lastname: Hoffman
authors.affiliation: Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Crutch
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D032882:Comprehension / Q000502:physiology; D005260:Female; D006801:Humans; D007600:Judgment / Q000502:physiology; D019359:Knowledge; D008297:Male; D010296:Parietal Lobe / Q000502:physiology*; D012660:Semantics; D013702:Temporal Lobe / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D055815:Young Adult
keywords: Anterior temporal lobe; Inferior parietal sulcus; Magnitude; Semantic cognition