title: pH-Sensitive drug delivery system based on modified dextrin coated mesoporous silica nanoparticles.
abstract: In this work, a novel pH-sensitive drug delivery system based on modified dextrin coated mesoporous silica nanoparticles (MSNs), DOX@MSN-DDA-CL, are prepared. The dextrin grafting on the surface of MSNs is oxidized by KIO4 to obtain dextrin dialdehyde, which is then cross-linked by tetraethylenepentamine through a pH-sensitive Schiff's base. Under physiological conditions, the cross-linked dextrin dialdehyde blocks the pores to prevent premature release of model drug doxorubicin hydrochloride (DOX). In the weak acidic environment, pH 6.0 in this work, the Schiff's base can be hydrolyzed and released the drug. The in vitro drug release studies at different pHs prove the pH-sensitivity of DOX@MSN-DDA-CL. The cytotoxicity and cell internalization behavior are also investigated in detail. In vivo tissue distribution and pharmacokinetics with a H22-bearing mouse animal mode are also studied, prove that DOX@MSN-DDA-CL has a longer retention time than that of pure DOX and can accumulate in tumor region via enhanced permeation and retention and nanomaterials-induced endothelial cell leakiness effects. In conclusion, the pH-sensitive modified dextrin/MSNs complex drug delivery system has a great potential for cancer therapy.
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University, Wuhan, Hubei 430062, PR China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Chen
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University, Wuhan, Hubei 430062, PR China.
authors.forename: Diwei
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Food Science and Technology, School of Bio-engineering, Hubei University of Technology, Wuhan, Hubei 430068, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Kuang
authors.affiliation: Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Li
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University, Wuhan, Hubei 430062, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University, Wuhan, Hubei 430062, PR China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Ye
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University, Wuhan, Hubei 430062, PR China.
authors.forename: Hongyang
authors.initials: H
authors.lastname: Qin
authors.affiliation: Hubei Research Institute of Products Quality Supervision and Inspection, Wuhan, Hubei 430061, PR China.
authors.forename: Yanglin
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University, Wuhan, Hubei 430062, PR China. Electronic address: licao0415@163.com.
authors.forename: Cao
authors.initials: C
authors.lastname: Li
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University, Wuhan, Hubei 430062, PR China. Electronic address: greatj650@hubu.edu.cn.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Jiang
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible; D003912:Dextrins / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014018:Tissue Distribution
chemical_list: D020099:Coated Materials, Biocompatible; D003912:Dextrins; D004337:Drug Carriers; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: Controlled release; Mesoporous silica nanoparticles; Modified dextrin