title: Dopamine D4 receptor antagonist inhibits melanogenesis through transcriptional downregulation of MITF via ERK signalling.
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Joon Min
authors.initials: JM
authors.lastname: Jung
authors.affiliation: Asan Institute for Life Science, Seoul, Korea.
authors.forename: Su Yeon
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Lee
authors.affiliation: Department of Genetic Engineering, College of Life Sciences, Kyung Hee University, Yongin, Korea.
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Hwang
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Chang
mesh_terms: D002470:Cell Survival; D004298:Dopamine / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006801:Humans; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000166:cytology* / Q000187:drug effects; D051739:Microphthalmia-Associated Transcription Factor / Q000378:metabolism*; D011725:Pyridines / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry; D012333:RNA, Messenger / Q000378:metabolism; D050638:Receptors, Dopamine D4 / Q000037:antagonists & inhibitors*; D015398:Signal Transduction
chemical_list: C493599:DRD4 protein, human; C103081:L 750667; C497234:MITF protein, human; D008543:Melanins; D051739:Microphthalmia-Associated Transcription Factor; D011725:Pyridines; D011758:Pyrroles; D012333:RNA, Messenger; D050638:Receptors, Dopamine D4; D048049:Extracellular Signal-Regulated MAP Kinases; D004298:Dopamine
keywords: 667 trihydrochloride; L-750; dopamine D4 receptor antagonist; extracellular signal-regulated kinase; melanogenesis; microphthalmia-associated transcription factor