title: Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus.
abstract: BACKGROUND
  Primary diffuse large B cell lymphoma (DLBCL) of the uterus is rare, and primary DLBCL arising from a uterine leiomyoma (collision tumor) has not been reported in the literature.
  
  
  METHODS
  We describe the clinical, histological, immunohistochemical, and molecular features of primary DLBCL arising from a leiomyoma in the uterine corpus. A 73-year-old female patient had a uterine mass for 23 years. An ultrasound scan revealed marked enlargement of the uterus, measuring 18.2 × 13 × 16.3 cm, with a 17.6 × 10.9 × 11.6 cm hypoechoic mass in the uterine corpus. The tumors consisted of medium- to large-sized cells exhibiting a diffuse pattern of growth with a well-circumscribed leiomyoma. The neoplastic cells strongly expressed CD79α, CD20 and PAX5. Molecular analyses indicated clonal B-cell receptor gene rearrangement.
  
  
  CONCLUSIONS
  To the best of our knowledge, no previous cases of primary DLBCL arising from a leiomyoma have been reported. It is necessary to differentiate a diagnosis of primary DLBCL arising from a leiomyoma from that of leiomyoma with florid reactive lymphocytic infiltration (lymphoma-like lesion). Careful analysis of clinical, histological, immunophenotypic, and genetic features is required to establish the correct diagnosis.
authors.affiliation: Department of Pathology, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China. zhaolianhua206@163.com.
authors.forename: Lianhua
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Pathology, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China. 375640711@qq.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Pathology, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China. 247105034@qq.com.
authors.forename: Qiushi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Pathology, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China. 182323266@qq.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Department of Pathology, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China. 44084700@qq.com.
authors.forename: Qingya
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Department of Pathology, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China. 1749765189@qq.com.
authors.forename: Hualiang
authors.initials: H
authors.lastname: Xiao
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D005260:Female; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D047368:Tumor Burden; D014594:Uterine Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor