title: Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients.
abstract: An abundance of data, known for decades, is available linking metals, such as lead and cadmium, with cardiovascular disease. However, the idea that these toxic metals could be a modifiable risk factor for atherosclerosis did not become apparent clinically until the completion of the Trial to Assess Chelation Therapy in 2012. This pivotal study was the first double-blind, randomized, controlled trial of its kind to demonstrate a clear improvement in cardiovascular outcomes with edetate disodium therapy in a secondary prevention, post-myocardial infarction population. This effect size was most striking in diabetic patients, where the efficacy of edetate disodium was comparable, if not superior, to that of current guideline-based therapies. Given the economic burden of diabetes and cardiovascular disease, the potential impact of this therapy could be enormous if the results of this study are replicated.
authors.affiliation: Columbia University Division of Cardiology, Mount Sinai Medical Center, Miami Beach FL, 4300 Alton Road, Miami Beach, FL, 33140, USA. gervasio.lamas@msmc.com.
authors.forename: Gervasio A
authors.initials: GA
authors.lastname: Lamas
authors.affiliation: Columbia University Division of Cardiology, Mount Sinai Medical Center, Miami Beach FL, 4300 Alton Road, Miami Beach, FL, 33140, USA.
authors.forename: Omar M
authors.initials: OM
authors.lastname: Issa
mesh_terms: D050197:Atherosclerosis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D065096:Calcium Chelating Agents / Q000008:administration & dosage* / Q000009:adverse effects; D015913:Chelation Therapy; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004492:Edetic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D000075322:Heavy Metal Poisoning; D006801:Humans; D019216:Metals, Heavy / Q000009:adverse effects; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control*; D011041:Poisoning; D012307:Risk Factors; D055502:Secondary Prevention / Q000379:methods*; D017741:Survivors; D016896:Treatment Outcome
chemical_list: D065096:Calcium Chelating Agents; D019216:Metals, Heavy; D004492:Edetic Acid
keywords: Chelation; Coronary artery disease; Diabetes; Metals; Myocardial infarction; TACT