title: Preparation of starch nanoparticles in water in oil microemulsion system and their drug delivery properties.
abstract: In this research, 1-hexadecyl-3-methylimidazolium bromide C16mimBr/butan-1-ol/cyclohexane/water ionic liquid microemulsion was prepared. The effects of n-alkyl alcohols, alkanes, water content and temperature on the properties of microemulsion were studied by dilution experiment. The microregion of microemulsion was identified by pseudo-ternary phase diagram and conductivity measurement. Then starch nanoparticles were prepared by water in oil (W/O) microemulsion-cross-linking methods with C16mimBr as surfactant. Starch nanoparticles with a mean diameter of 94.3nm and narrow size distribution (SD=3.3) were confirmed by dynamic light scattering (DLS). Scanning electron microscope (SEM) data revealed that starch nanoparticles were spherical granules with the size about 60nm. Moreover the results of Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) demonstrated the formation of cross-linking bonds in starch molecules. Finally, the drug loading and releasing properties of starch nanoparticles were investigated with methylene blue (MB) as drug model. This work may provide an efficient pathway to synthesis starch nanoparticles.
authors.affiliation: Carbohydrate Lab, College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, China.
authors.forename: Xinge
authors.initials: X
authors.lastname: Wang
authors.affiliation: Carbohydrate Lab, College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, China; College of Food Sciences & Engineering, Hainan University, 58 People Road, Haikou, China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Chen
authors.affiliation: Carbohydrate Lab, College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, China. Electronic address: zhgluo@scut.edu.cn.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Carbohydrate Lab, College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, China. Electronic address: lfxfu@scut.edu.cn.
authors.forename: Xiong
authors.initials: X
authors.lastname: Fu
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D000067493:Dynamic Light Scattering; D004655:Emulsions / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry; D008751:Methylene Blue / Q000737:chemistry* / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D009821:Oils / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: C528275:1-hexadecyl-3-methylimidazolium bromide; D004337:Drug Carriers; D004655:Emulsions; D007093:Imidazoles; D009821:Oils; D014867:Water; D013213:Starch; D008751:Methylene Blue
keywords: C(16)mimBr; Ionic liquid; Microemulsion; Nanoparticles; Starch