title: Bone regeneration and infiltration of an anisotropic composite scaffold: an experimental study of rabbit cranial defect repair.
abstract: Tissue formation on scaffold outer edges after implantation may restrict cell infiltration and mass transfer to/from the scaffold center due to insufficient interconnectivity, leading to incidence of a necrotic core. Herein, a nano-hydroxyapatite/polyamide66 (n-HA/PA66) anisotropic scaffold with axially aligned channels was prepared with the aim to enhance pore interconnectivity. Bone tissue regeneration and infiltration inside of scaffold were assessed by rabbit cranial defect repair experiments. The amount of newly formed bone inside of anisotropic scaffold was much higher than isotropic scaffold, e.g., after 12 weeks, the new bone volume in the inner pores was greater in the anisotropic scaffolds (>50%) than the isotropic scaffolds (<30%). The results suggested that anisotropic scaffolds could accelerate the inducement of bone ingrowth into the inner pores in the non-load-bearing bone defects compared to isotropic scaffolds. Thus, anisotropic scaffolds hold promise for the application in bone tissue engineering.
authors.affiliation: a Research Center for Nano Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , P.R. China.
authors.forename: Jidong
authors.initials: J
authors.lastname: Li
authors.affiliation: a Research Center for Nano Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , P.R. China.|c Division of Biomedical Engineering , College of Engineering, University of Saskatchewan , Saskatoon , Canada.
authors.forename: Fu
authors.initials: F
authors.lastname: You
authors.affiliation: a Research Center for Nano Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , P.R. China.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Research Center for Nano Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zuo
authors.affiliation: a Research Center for Nano Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , P.R. China.
authors.forename: Limei
authors.initials: L
authors.lastname: Li
authors.affiliation: a Research Center for Nano Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , P.R. China.
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: b West China School of Stomatology , Sichuan University , Chengdu , P.R. China.
authors.forename: Yili
authors.initials: Y
authors.lastname: Qu
authors.affiliation: d Department of Orthopaedic Surgery, Yongchuan Hospital , Chongqing Medical University , Chongqing , P.R. China.
authors.forename: Minpeng
authors.initials: M
authors.lastname: Lu
authors.affiliation: b West China School of Stomatology , Sichuan University , Chengdu , P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Man
authors.affiliation: a Research Center for Nano Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , P.R. China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zou
mesh_terms: D000818:Animals; D016880:Anisotropy; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D017886:Durapatite / Q000737:chemistry; D009757:Nylons / Q000737:chemistry; D010012:Osteogenesis / Q000187:drug effects; D016062:Porosity; D011817:Rabbits; D051381:Rats; D012886:Skull / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D009757:Nylons; D017886:Durapatite
keywords: Nano-hydroxyapatite/polyamide; anisotropic scaffold; bone tissue infiltration; rabbit cranial defect