title: Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury.
abstract: The liver biopsy remains a valuable tool in the diagnosis of drug-induced liver injury (DILI). The Digestive Disease Week Japan 2004 (DDW-J) scale proposed as an objective tool for the diagnosis of DILI has been widely used in Japan. So far, the histological features have not been compared with DDW-J scale in detail. Herein, we examined the correlation between liver biopsy findings and clinical features, particularly DDW-J scales. A total of 80 patients with liver injuries of unknown cause were enrolled. Based on the histological findings, these cases were categorized into 3 groups: A (DILI was strongly suspected), B (DILI was suspected), and C (DILI should be considered in the differential diagnosis). Histological groups and DDW-J scale were moderately correlated (κ = 0.60). The mean total DDW-J scale scores were as follows: 4.89 for A, 3.26 for B, and 0.75 for C (p < 0.05). While hepatocellular type was coincided in a majority of cases by histological and DDW-J scale evaluation, cholestatic type was not well coincided. In conclusion, biopsy findings and DDW-J scale were well correlated, and the hepatocellular type of liver injuries was well coincided by both evaluations, though there were several discrepant cases, particularly in cholestatic type.
authors.affiliation: Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Tsutsui
authors.affiliation: Department of Pathology, Shizuoka Cancer Center, Shizuoka 411-0934, Japan; Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-0934, Japan.
authors.forename: Yasuni
authors.initials: Y
authors.lastname: Nakanuma
authors.affiliation: Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Takaguchi
authors.affiliation: Section of Diagnostic Pathology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Gastroenterology, Tokushima Prefectural Central Hospital, Tokushima 770-0042, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibata
authors.affiliation: Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Baba
authors.affiliation: Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Senoh
authors.affiliation: Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Nagano
authors.affiliation: Section of Diagnostic Pathology, Kanazawa University Hospital, Kanazawa 920-0934, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ikeda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007564:Japan; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult