title: What do we know about sulforaphane protection against photoaging?
abstract: Sulforaphane (SFN), a natural compound occurring in cruciferous vegetables, has been known for years as a chemopreventive agent against many types of cancer. Recently, it has been investigated as an antioxidant and anti-aging agent, and interesting conclusions have been made over the last decade. SFN demonstrated protective effects against ultraviolet (UV)-induced skin damage through several mechanisms of action, for example, decrease of reactive oxygen species production, inhibition of matrix metalloproteinase expression, and induction of phase 2 enzymes. SFN used as a protective agent against UV damage is a whole new matter, and it seems to be a very promising ingredient in upcoming anti-aging drugs and cosmetics.
authors.affiliation: Laboratoire de Chimie Bioanalytique, Toxicologie et Chimie Physique Appliquée, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Sohely
authors.initials: S
authors.lastname: Sikdar
authors.affiliation: Laboratoire de Chimie Bioanalytique, Toxicologie et Chimie Physique Appliquée, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Maria
authors.initials: M
authors.lastname: Papadopoulou
authors.affiliation: Laboratoire de Chimie Bioanalytique, Toxicologie et Chimie Physique Appliquée, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Jacques
authors.initials: J
authors.lastname: Dubois
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D006801:Humans; D017879:Isothiocyanates / Q000494:pharmacology*; D000072019:Kelch-Like ECH-Associated Protein 1 / Q000187:drug effects; D020781:Matrix Metalloproteinase 1 / Q000187:drug effects; D019278:Matrix Metalloproteinase 3 / Q000187:drug effects; D051267:NF-E2-Related Factor 2 / Q000187:drug effects; D016328:NF-kappa B / Q000187:drug effects; D011837:Radiation-Protective Agents / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D013454:Sulfoxides; D018808:Transcription Factor AP-1 / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D016588:Anticarcinogenic Agents; D017879:Isothiocyanates; C431364:KEAP1 protein, human; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495635:NFE2L2 protein, human; D011837:Radiation-Protective Agents; D013454:Sulfoxides; D018808:Transcription Factor AP-1; D019278:Matrix Metalloproteinase 3; D020781:Matrix Metalloproteinase 1; C016766:sulforaphane
keywords: aging; skin; sulforaphane; ultraviolet