title: No sex difference in overall P-glycoprotein activity as assessed by talinolol disposition in humans.
abstract: OBJECTIVE
  The aim of this study was to investigate the sex-dependent difference in P-glycoprotein activity as measured by the probe drug talinolol.
  
  
  METHODS
  A randomized, single-blind, parallel study was carried out in 20 healthy male and 20 healthy female volunteers. The pharmacokinetics of talinolol were measured after single oral dosing of 50-mg tablet and the pharmacokinetic parameters for male and female subjects were compared after excluding the potential influence of P-gp genetic polymorphisms.
  
  
  RESULTS
  Talinolol AUC(0-48h) in the female subjects was 23.5% (p = 0.003) higher than that of male subjects. There was no significant sex difference in weight-corrected oral clearance, AUC, or other PK parameters.
  
  
  CONCLUSIONS
  The AUC and other PK data of talinolol, corrected for body weight, did not differ between genders after oral administration. The observed sex difference in talinolol systemic exposure is of little clinical relevance. The overall activity of P-gp shows no sex-related difference.
authors.forename: Bo
authors.initials: B
authors.lastname: Long
authors.forename: Yuan-Qi
authors.initials: YQ
authors.lastname: Su
authors.forename: Ying
authors.initials: Y
authors.lastname: Xia
authors.forename: Yan-Ye
authors.initials: YY
authors.lastname: Zou
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
authors.forename: Zhong-Jie
authors.initials: ZJ
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Lin
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D058671:Adrenergic beta-1 Receptor Antagonists / Q000493:pharmacokinetics*; D000328:Adult; D019540:Area Under Curve; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011412:Propanolamines / Q000493:pharmacokinetics*; D012727:Sex Characteristics; D016037:Single-Blind Method
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D058671:Adrenergic beta-1 Receptor Antagonists; D011412:Propanolamines; C011550:talinolol