title: miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis.
abstract: Rheumatoid arthritis (RA) is an inflammatory disease that primarily affects joints. This autoimmune disease pathogenesis is related to cytokine signaling. In this review, we have described the existence of various microRNAs (miRNAs) involved in regulation of major protein cascades of cytokine signaling associated with RA. Moreover, we have tried to portray the role of various miRNAs in different cytokines such as TNF-α, IL-1, IL-6, IL-10, IL-17, IL-18, IL-21, and granulocyte macrophage colony-stimulating factor (GMCSF). Along with this, we have also discussed the miRNA regulation in T cells and synovial tissue. From the analyzed data, we suggest that miR-146a and miR-155 might be the potential therapeutic target for treating RA. The insight illustrated in this review will offer a better understanding of the role of miRNA in cytokine signaling pathways and inflammation during RA and could project them as diagnostic or therapeutic agents in near future.
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Chuncheon Sacred Heart Hospital, Hallym University, Chuncheon, 200704, Republic of Korea.
authors.forename: Ashish Ranjan
authors.initials: AR
authors.lastname: Sharma
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Chuncheon Sacred Heart Hospital, Hallym University, Chuncheon, 200704, Republic of Korea.
authors.forename: Garima
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Chuncheon Sacred Heart Hospital, Hallym University, Chuncheon, 200704, Republic of Korea.
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Chuncheon Sacred Heart Hospital, Hallym University, Chuncheon, 200704, Republic of Korea.|Department of Bioinformatics, School of Computer Sciences, Galgotias University, Greater Noida, 203201, Uttar Pradesh, India.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D016207:Cytokines; D035683:MicroRNAs
keywords: autoimmune disease; cytokine signaling; inflammation; microRNA; rheumatoid arthritis