title: Tissue-Resident T Cells as the Central Paradigm of Chlamydia Immunity.
abstract: For almost 2 decades, results from Chlamydia pathogenesis investigations have been conceptualized using a cytokine polarization narrative. Recent viral immunity studies identifying protective tissue-resident memory T cells (Trm) suggest an alternative paradigm based on localized immune networks. As Chlamydia vaccines enter the preclinical pipeline and, in the case of an attenuated trachoma vaccine, are given to human subjects, it may be useful to ask whether cytokine polarization is the appropriate framework for understanding and evaluating vaccine efficacy. In this review, we revisit C. trachomatis pathogenesis data from mice and humans using a Trm narrative and note a comfortable concordance with the Chlamydia pathogenesis literature.
authors.affiliation: Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Raymond M
authors.initials: RM
authors.lastname: Johnson
authors.affiliation: Vaccine Research Laboratory, University of British Columbia Centre for Disease Control, Vancouver, Canada robert.brunham@bccdc.ca.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Brunham
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000592:standards*; D002689:Chlamydia / Q000276:immunology*; D002690:Chlamydia Infections / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D001428:Bacterial Vaccines