title: [Prostate cancer stem cell and drug resistance].
abstract: Cancer tissues are comprised of cell population including a variety of cells, such as stem cell-like cancer cells, upon which a hierarchical society is constructed. This hypothesis has been applied not only to leukemia, in which the hypothesis was first experimentally confirmed, but also to solid cancers. Recent topics shed light on the modified heterogeneity by various treatments which evolve disease progression. In prostate cancer, the identification of cancer stem cells using surface markers and the relationship with prostate origin are of current interest. This article reviews studies related to the development of prostate cancer and introduce recent progress of our project, focusing on cancer stemness and drug resistance.
authors.forename: Takeo
authors.initials: T
authors.lastname: Kosaka
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Oya
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D065150:Cellular Reprogramming; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008297:Male; D014411:Neoplastic Stem Cells; D011471:Prostatic Neoplasms / Q000628:therapy; D012008:Recurrence
chemical_list: D000970:Antineoplastic Agents