title: Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia.
abstract: In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in conformance with Hardy-Weinberg equilibrium (HWE; P = 0.46 and 0.17). Unconditional logistic regression analyses revealed that individuals carrying the CC genotype of IL-10 -819T/C were associated with an increased risk of preeclampsia compared to the TT genotype. The odds ratio (95% confidence interval) for the CC genotype of IL-10 -819T/C was 1.71 (1.07-3.27) compared to the TT genotype. In conclusion, the results of our study indicated that the IL-10 -819T/C polymorphism was associated with an increased risk of preeclampsia in a Chinese population.
authors.affiliation: Department of Obstetrics, Eighth People's Hospital of Qingdao, Qingdao, China.|Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Qingdao Hiser Medical Group, Qingdao, China.
authors.forename: F Y
authors.initials: FY
authors.lastname: Gao
authors.affiliation: Department of Internal Medicine, Qingdao Women and Children Hospital, Qingdao, China.
authors.forename: X R
authors.initials: XR
authors.lastname: Liu
authors.affiliation: Department of Obstetrics/Gynaecology, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Obstetrics, Eighth People's Hospital of Qingdao, Qingdao, China.
authors.forename: M
authors.initials: M
authors.lastname: Ji
authors.affiliation: Department of Obstetrics, Eighth People's Hospital of Qingdao, Qingdao, China.
authors.forename: J
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Obstetrics/Gynaecology, Shandong Provincial Hospital, Jinan, China.
authors.forename: X T
authors.initials: XT
authors.lastname: Wang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D042241:Early Diagnosis; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D016015:Logistic Models; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D011247:Pregnancy; D011401:Promoter Regions, Genetic; D012306:Risk
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10