title: [Super-Elderly Patient with Recurrent Rectal Cancer with Liver Metastases Effectively Treated with Capecitabine plus Bevacizumab Chemotherapy--Report of a Case].
abstract: The safety and feasibility of chemotherapy for super-elderly patients (over 85 years old) has not been clarified yet. We report an extremely aged patient with recurrent rectal cancer that was successfully treated with capecitabine plus bevacizumab chemotherapy. An 85-year-old-woman underwent a Hartmann procedure for rectal cancer. Nine months after surgery, tumor markers were elevated. CT and MRI revealed liver metastases in S5 and S7. We administered capecitabine plus bevacizumab chemotherapy. Tumor makers were normalized after 2 courses, and the liver metastases disappeared after 6 courses. Although Grade 1 hypertension developed, no other adverse event occurred. Chemotherapy has been safely performed for 20 courses. The patient's PS score has been maintained at 0, and she has been under treatment as an outpatient. We suggest that capecitabine plus bevacizumab chemotherapy is an effective regimen for extremely aged patients with recurrent colorectal cancer.
authors.affiliation: Dept. of Surgery, Kinan Hospital.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Satoru
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Shigeo
authors.initials: S
authors.lastname: Fujita
authors.forename: Hajime
authors.initials: H
authors.lastname: Hirose
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sugimoto
authors.forename: Toshiya
authors.initials: T
authors.lastname: Michiura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamabe
authors.forename: Makio
authors.initials: M
authors.lastname: Nagaoka
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000008:administration & dosage; D000069287:Capecitabine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000068258:Bevacizumab; D000069287:Capecitabine