title: Changes in mitral annular morphology and function in young patients with type 1 diabetes mellitus-results from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study.
abstract: BACKGROUND
  Alterations in mitral annular size and function could be demonstrated in cardiomyopathies and ischaemic heart disease. The present study was designed to evaluate mitral annulus (MA) morphology and function in young type 1 diabetes mellitus (T1DM) patients by three-dimensional speckle tracking echocardiography (3DSTE) and to compare their results to matched healthy controls.
  
  
  METHODS
  The study comprised 18 patients with T1DM (mean age: 33.0±8.0 years). Their results were compared to that of 20 age- and gender-matched healthy controls (mean age: 37.8±10.9 years). Complete two-dimensional (2D) Doppler echocardiography and 3DSTE have been performed in all cases.
  
  
  RESULTS
  No significant differences could be demonstrated in demographic and standard echocardiographic parameters between the groups. Significantly enlarged diastolic MA diameter (2.87±0.27 mm vs. 2.58±0.32 mm, P=0.01), MA diameter index 1.61±0.20 cm/m(2) vs. 1.30±0.39 cm/m(2), P=0.008, and MA area index (4.81±0.88 cm(2)/m(2) vs. 3.91±1.35 cm(2)/m(2), P=0.03) could be demonstrated in T1DM together with augmented MA fractional shortening (28.64±9.63% vs. 20.35±12.50%, P=0.05).
  
  
  CONCLUSIONS
  Early alterations in MA size and function could be demonstrated in young patients with T1DM by 3DSTE.
authors.affiliation: 1 2nd Department of Medicine and Cardiology Centre, 2 1st Department of Medicine, 3 Department of Pharmacology and Pharmacotherapy, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Nemes
authors.affiliation: 1 2nd Department of Medicine and Cardiology Centre, 2 1st Department of Medicine, 3 Department of Pharmacology and Pharmacotherapy, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
authors.forename: Györgyike Ágnes
authors.initials: GÁ
authors.lastname: Piros
authors.affiliation: 1 2nd Department of Medicine and Cardiology Centre, 2 1st Department of Medicine, 3 Department of Pharmacology and Pharmacotherapy, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Domsik
authors.affiliation: 1 2nd Department of Medicine and Cardiology Centre, 2 1st Department of Medicine, 3 Department of Pharmacology and Pharmacotherapy, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
authors.forename: Anita
authors.initials: A
authors.lastname: Kalapos
authors.affiliation: 1 2nd Department of Medicine and Cardiology Centre, 2 1st Department of Medicine, 3 Department of Pharmacology and Pharmacotherapy, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Lengyel
authors.affiliation: 1 2nd Department of Medicine and Cardiology Centre, 2 1st Department of Medicine, 3 Department of Pharmacology and Pharmacotherapy, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
authors.forename: Tamás T
authors.initials: TT
authors.lastname: Várkonyi
authors.affiliation: 1 2nd Department of Medicine and Cardiology Centre, 2 1st Department of Medicine, 3 Department of Pharmacology and Pharmacotherapy, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Orosz
authors.affiliation: 1 2nd Department of Medicine and Cardiology Centre, 2 1st Department of Medicine, 3 Department of Pharmacology and Pharmacotherapy, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Forster
keywords: Type 1 diabetes; echocardiography; mitral annulus (MA); three-dimensional