title: Palladium(II)-Catalyzed, Heteroatom-Directed, Regioselective C-H Nitration of Anilines Using Pyrimidine as a Removable Directing Group.
abstract: A new palladium-catalyzed, heteroatom-directed strategy for C-H nitration of anilines is described. This C-H functionalization reaction is highly ortho-selective and results in very good yields. The highlight of the work is the use of pyrimidine as the removable directing group. This approach constitutes one of the rare methods of ortho-nitration of anilines, a reaction that is normally very difficult to achieve via traditional approaches.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road, Bhauri, Bhopal 462066, India.
authors.forename: Govind Goroba
authors.initials: GG
authors.lastname: Pawar
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road, Bhauri, Bhopal 462066, India.
authors.forename: Abhilashamole
authors.initials: A
authors.lastname: Brahmanandan
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road, Bhauri, Bhopal 462066, India.
authors.forename: Manmohan
authors.initials: M
authors.lastname: Kapur