title: Recent Progress in the Research of Eosinophilic Esophagitis and Gastroenteritis.
abstract: Eosinophilic esophagitis (EoE) and gastroenteritis are allergic gastrointestinal diseases mainly caused by food allergens. The number of patients with EoE is rapidly increasing in both Western and Asian countries. Basic knowledge of these diseases has mainly come from studies of EoE and Th2 type allergic reactions, including IL-5, IL-13, and IL-15, thymic stromal protein, and eotaxin 3, which are considered to have important roles. For a diagnosis of EoE, endoscopic abnormalities and histological confirmation of dense eosinophile infiltration in the esophageal epithelial layer are important, in addition to identifying dysphagia symptoms. As for eosinophilic gastroenteritis, blood test findings are more useful and the role of an endoscopic examination is reduced. For both diseases, the infection rate of Helicobacter pylori is lower than in healthy controls. Glucocorticoid administration is standard treatment for these diseases, while proton pump inhibitors are frequently effective for EoE.
authors.affiliation: Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Norihisa
authors.initials: N
authors.lastname: Ishimura
authors.forename: Naoki
authors.initials: N
authors.lastname: Oshima
authors.forename: Hironobu
authors.initials: H
authors.lastname: Mikami
authors.forename: Eiko
authors.initials: E
authors.lastname: Okimoto
authors.forename: Di Jin
authors.initials: DJ
authors.lastname: Jiao
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
mesh_terms: D000075906:Chemokine CCL26; D019742:Chemokines, CC / Q000276:immunology*; D004751:Enteritis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D004802:Eosinophilia / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D057765:Eosinophilic Esophagitis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D005512:Food Hypersensitivity / Q000188:drug therapy / Q000276:immunology*; D005756:Gastritis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D005938:Glucocorticoids / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D018793:Interleukin-13 / Q000276:immunology*; D019409:Interleukin-15 / Q000276:immunology*; D015848:Interleukin-5 / Q000276:immunology*; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D018418:Th2 Cells / Q000276:immunology*
chemical_list: C120429:CCL26 protein, human; D000075906:Chemokine CCL26; D019742:Chemokines, CC; D005938:Glucocorticoids; C569274:IL15 protein, human; C508599:IL5 protein, human; D018793:Interleukin-13; D019409:Interleukin-15; D015848:Interleukin-5; D054328:Proton Pump Inhibitors