title: Association between Carotid Intima-Media Thickness and Cognitive Impairment in a Chinese Stroke Population: A Cross-sectional Study.
abstract: This study aimed to investigate the potential associations between carotid intima-media thickness and cognitive impairment among patients with acute ischemic stroke and to identify the clinical implications. We measured carotid intima-media thickness (IMT) and performed the Mini-Mental State Examination (MMSE) upon the admission of 1,826 acute ischemic stroke patients. The association between IMT and cognitive impairment evaluated by the MMSE was assessed with a multivariate regression analysis. Other clinical variables of interest were also assessed. After adjusting for potential confounders, participants in the highest IMT quartile had a higher likelihood of having cognitive impairments compared with the lowest IMT quartile (odds ratio: 3.01, 95% confidence interval: 2.07-4.37, p < 0.001). Stratified analyses indicated that this positive correlation was similar for the maxIMT and meanIMT of carotid artery measurements. A positive correlation was found between IMT and cognitive impairment in participants with acute ischemic stroke.
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yue
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
authors.forename: Anxin
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Zhejiang University, Zhejiang, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Neurology, Shanxi People's Hospital, Shanxi Medical University, Shanxi, China.
authors.forename: Fengyun
authors.initials: F
authors.lastname: Hu
authors.affiliation: Department of Neurology, The Third Hospital of Shijiazhuang, Shijiazhuang, China.
authors.forename: Yunshu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiao Tong University, Xian, China.
authors.forename: Meiying
authors.initials: M
authors.lastname: Deng
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Neurology, Guizhou People's Hospital, Guizhou, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Inspection, Guizhou People's Hospital, Guizhou, China.
authors.forename: Zhenxuan
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Department of Traditional Chinese Medicine, Beijing Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D059168:Carotid Intima-Media Thickness; D002681:China; D060825:Cognitive Dysfunction / Q000453:epidemiology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D012307:Risk Factors; D013223:Statistics as Topic; D020521:Stroke / Q000453:epidemiology / Q000503:physiopathology*