title: Adventitious sporulation in Fusarium: The yeast that were not.
abstract: In immunocompromised patients, Fusarium species cause infections that lead to high mortality. Our case report describes a case of disseminated fusariosis in a neutropenic patient with AML after myelosuppressive chemotherapy, and a neutropenic multiple myeloma patient with Fusarium fungemia awaiting stem cell collection. Both cases highlight the fact that Fusarium can grow as yeast-like structures in the blood causing a delay in diagnosis, and that Fusarium has a tendency to be a resistant organism. Fusarium was only susceptible to amphotericin B in both cases, but we chose to continue treatment with voriconazole in the first case with disseminated infection, despite culture results, in view of his good clinical response. Despite high mortality rates in disseminated infection, our two patients had good outcomes.
authors.affiliation: University of Arkansas for Medical Sciences, Department of Internal Medicine, Little Rock, AR, USA.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Lockwood
authors.affiliation: University of Arkansas for Medical Sciences, Department of Internal Medicine, Little Rock, AR, USA; University of Arkansas for Medical Sciences, Division of Infectious Disease, Little Rock, AR, USA; University of Arkansas for Medical Sciences, Myeloma Institute, Little Rock, AR, USA.
authors.forename: Juan Carlos Rico
authors.initials: JC
authors.lastname: Crescencio
keywords: Adventitious; Fusarium; Immunosuppresion; Isavuconazole; Neutropenia; Sporulation