title: 2',4'-dihydroxychalcone, a flavonoid isolated fromHerba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis.
abstract: Natural products are a promising source for the development of novel cancer therapies, due to their potential effectiveness and low toxicity proﬁles. As a main component ofHerba oxytropis, 2',4'-dihydroxychalcone (TFC) is known to demonstrate anti-tumor activityin vitro. In the present study, TFC was found to potently inhibit proliferation and induce apoptosis in PC-3 human prostate cancer cells in a dose-dependent manner. The results demonstrated that the induction of apoptosis is associated with cell cycle arrest at the G0/G1 phase and activation of caspase-3/-7. Additional mechanistic studies of two biomarkers, phosphatase and tensin homolog (PTEN) and cyclin-dependent kinase inhibitor 1B (p27Kip1), in prostate cancer revealed that TFC treatment significantly upregulated the expression of PTEN and p27Kip1. The findings of the present study indicate that TFC-induced apoptosis in PC-3 cells via upregulation of PTEN and p27Kip1, which results in cell cycle arrest in G0/G1 phase, activation of caspase-3/-7 and induction of apoptosis. Therefore, TFC may be a potential compound for human prostate cancer therapy.
authors.affiliation: Department of Pharmacy, The First People's Hospital of Zhenjiang, Zhenjiang, Jiangsu 212002, P.R. China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: Department of Pharmacy, The First People's Hospital of Zhenjiang, Zhenjiang, Jiangsu 212002, P.R. China.
authors.forename: Mingchang
authors.initials: M
authors.lastname: Zou
authors.affiliation: Department of Pharmacy, The First People's Hospital of Zhenjiang, Zhenjiang, Jiangsu 212002, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, The First People's Hospital of Zhenjiang, Zhenjiang, Jiangsu 212002, P.R. China.
authors.forename: Qiheng
authors.initials: Q
authors.lastname: Li
keywords: 2′,4′-dihydroxychalcone; apoptosis; cell cycle; cyclin-dependent kinase inhibitor 1B; phosphatase and tensin homolog; prostate cancer