title: Estimating the Incidence of Acute Infectious Intestinal Disease in the Community in the UK: A Retrospective Telephone Survey.
abstract: OBJECTIVE
  To estimate the burden of intestinal infectious disease (IID) in the UK and determine whether disease burden estimations using a retrospective study design differ from those using a prospective study design.
  
  
  METHODS
  A retrospective telephone survey undertaken in each of the four countries comprising the United Kingdom. Participants were randomly asked about illness either in the past 7 or 28 days.
  
  
  METHODS
  14,813 individuals for all of whom we had a legible recording of their agreement to participate.
  
  
  RESULTS
  Self-reported IID, defined as loose stools or clinically significant vomiting lasting less than two weeks, in the absence of a known non-infectious cause.
  
  
  RESULTS
  The rate of self-reported IID varied substantially depending on whether asked for illness in the previous 7 or 28 days. After standardising for age and sex, and adjusting for the number of interviews completed each month and the relative size of each UK country, the estimated rate of IID in the 7-day recall group was 1,530 cases per 1,000 person-years (95% CI: 1135-2113), while in the 28-day recall group it was 533 cases per 1,000 person-years (95% CI: 377-778). There was no significant variation in rates between the four countries. Rates in this study were also higher than in a related prospective study undertaken at the same time.
  
  
  CONCLUSIONS
  The estimated burden of disease from IID varied dramatically depending on study design. Retrospective studies of IID give higher estimates of disease burden than prospective studies. Of retrospective studies longer recall periods give lower estimated rates than studies with short recall periods. Caution needs to be exercised when comparing studies of self-reported IID as small changes in study design or case definition can markedly affect estimated rates.
authors.affiliation: Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Laura
authors.initials: L
authors.lastname: Viviani
authors.affiliation: The Norwich School of Medicine, University of East Anglia, Norwich, United Kingdom.
authors.forename: Mike
authors.initials: M
authors.lastname: van der Es
authors.affiliation: The Norwich School of Medicine, University of East Anglia, Norwich, United Kingdom.
authors.forename: Lisa
authors.initials: L
authors.lastname: Irvine
authors.affiliation: Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Clarence C
authors.initials: CC
authors.lastname: Tam
authors.affiliation: Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Laura C
authors.initials: LC
authors.lastname: Rodrigues
authors.affiliation: Institute of Infection and Global Health, Liverpool University, Liverpool, United Kingdom.
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Jackson
authors.affiliation: Institute of Infection and Global Health, Liverpool University, Liverpool, United Kingdom.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: O'Brien
authors.affiliation: The Norwich School of Medicine, University of East Anglia, Norwich, United Kingdom.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hunter
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology*; D003967:Diarrhea / Q000453:epidemiology / Q000209:etiology; D004751:Enteritis / Q000453:epidemiology*; D005260:Female; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012494:Sampling Studies; D057566:Self Report; D017678:Sex Distribution; D013689:Telephone; D006113:United Kingdom / Q000453:epidemiology; D014839:Vomiting / Q000453:epidemiology / Q000209:etiology; D055815:Young Adult