title: [Treating Side Effects of FOLFIRINOX--A Study of the Effect of Hange-Shashin-To on Preventing Diarrhea].
abstract: OBJECTIVE
  FOLFIRINOX is an effective therapy for unresectable advanced pancreatic cancer. However, FOLFIRINOX has side effects of blood and gastrointestinal toxicity. Diarrhea, one of the side effects of CPT-11, sometimes becomes serious. We studied whether Hange-shashin-to could prevent diarrhea caused by CPT-11.
  
  
  METHODS
  Seven patients who were diagnosed with unresectable pancreatic cancer, either Stage Ⅳor recurrent disease, were enrolled. They took 2.5 g of Hange-shashin-to before each meal starting one day before FOLFIRINOX, and continued taking it for one week. We examined the occurrence of diarrhea by using CTCAE retrospectively.
  
  
  RESULTS
  The median age was 61 years. The median number of chemotherapy courses was 4. The frequency of diarrhea was lower, compared to the results of ACCORD11 trial and the domestic phaseⅡ clinical trials. In addition, Grade 3 or more serious diarrhea was not observed, even in the patients with genetic polymorphisms of UGT1A1.
  
  
  CONCLUSIONS
  The incidence of diarrhea in patients treated with Hange-shashin-to in our department was lower compared to the ACCORD11 trial and domestic phase Ⅱ clinical trials. Hange-shashin-to is useful to allay the severity of diarrhea caused by CPT-11 in FOLFIRINOX therapy.
authors.affiliation: Dept. of Organ Regulatory Surgery, Fukushima Medical University.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hoshi
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kofunato
authors.forename: Rei
authors.initials: R
authors.lastname: Yashima
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Shimura
authors.forename: Seiichi
authors.initials: S
authors.lastname: Takenoshita
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D014453:Glucuronosyltransferase / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D000099148:UGT1A1 Enzyme
chemical_list: D004365:Drugs, Chinese Herbal; D014453:Glucuronosyltransferase; D000099148:UGT1A1 Enzyme; C088236:hange-shashinto