title: Measuring free-living physical activity in COPD patients: Deriving methodology standards for clinical trials through a review of research studies.
abstract: This article presents a review of the research literature to identify the methodology used and outcome measures derived in the use of accelerometers to measure free-living activity in patients with COPD. Using this and existing empirical validity evidence we further identify standards for use, and recommended clinical outcome measures from continuous accelerometer data to describe pertinent measures of sedentary behaviour and physical activity in this and similar patient populations. We provide measures of the strength of evidence to support our recommendations and identify areas requiring continued research. Our findings support the use of accelerometry in clinical trials to understand and measure treatment-related changes in free-living physical activity and sedentary behaviour in patient populations with limited activity.
authors.affiliation: Product Innovation, ICON Clinical Research Ltd., Unit 2, Globeside Business Park, Marlow, Buckinghamshire, UK.
authors.forename: Bill
authors.initials: B
authors.lastname: Byrom
authors.affiliation: School of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK.
authors.forename: David A
authors.initials: DA
authors.lastname: Rowe
mesh_terms: D061725:Accelerometry; D002986:Clinical Trials as Topic / Q000379:methods / Q000592:standards; D015444:Exercise; D006801:Humans; D018670:Monitoring, Ambulatory / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000523:psychology*; D057185:Sedentary Behavior
keywords: Accelerometry; COPD; Clinical trials; Free-living activity; Sedentary behaviour; Study design