title: New Atlanta Classification of acute pancreatitis in intensive care unit: Complications and prognosis.
abstract: BACKGROUND
  The updated Atlanta Classification of acute pancreatitis (AP) in adults defined three levels of severity according to the presence of local and/or systemic complications and presence and length of organ failure. No study focused on complications and mortality of patients with moderately severe AP admitted to intensive care unit (ICU). The main aim of this study is to describe the complications developed and outcomes of these patients and compare them to those with severe AP.
  
  
  METHODS
  Prospective, observational study. We included patients with acute moderately severe or severe AP admitted in a medical-surgical ICU during 5years. We collected demographic data, admission criteria, pancreatitis etiology, severity of illness, presence of organ failure, local and systemic complications, ICU length of stay, and mortality.
  
  
  RESULTS
  Fifty-six patients were included: 12 with moderately severe AP and 44 with severe. All patients developed some kind of complications without differences on complications rate between moderately severe or severe AP. All the patients present non-infectious systemic complications, mainly acute respiratory failure and hemodynamic failure. 82.1% had an infectious complication, mainly non-pancreatic infection (66.7% on moderately severe AP vs. 79.5% on severe, p=0.0443). None of the patients with moderately severe AP died during their intensive care unit stay vs. 29.5% with severe AP (p=0.049).
  
  
  CONCLUSIONS
  Moderately severe AP has a high rate of complications with similar rates to patients with severe AP admitted to ICU. However, their ICU mortality remains very low, which supports the existence of this new group of pancreatitis according to their severity.
authors.affiliation: Intensive Care Unit, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain; University of Alcalá, Alcalá de Henares, Madrid, Spain. Electronic address: consuelopintado@yahoo.es.
authors.forename: María-Consuelo
authors.initials: MC
authors.lastname: Pintado
authors.affiliation: Intensive Care Unit, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Trascasa
authors.affiliation: Intensive Care Unit, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Arenillas
authors.affiliation: Intensive Care Unit, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
authors.forename: Yaiza Ortiz
authors.initials: YO
authors.lastname: de Zárate
authors.affiliation: Intensive Care Unit, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Pardo
authors.affiliation: Intensive Care Unit, Hospital Universitario Ramón y Cajal, Madrid, Madrid, Spain.
authors.forename: Aaron
authors.initials: A
authors.lastname: Blandino Ortiz
authors.affiliation: Intensive Care Unit, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain; University of Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Raúl
authors.initials: R
authors.lastname: de Pablo
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000145:classification* / Q000150:complications* / Q000401:mortality*; D011379:Prognosis; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000453:epidemiology; D012720:Severity of Illness Index; D013030:Spain
keywords: Complications; Intensive care unit; Outcomes assessment; Pancreatitis