title: Cardiac Purkinje fibers and arrhythmias; The GK Moe Award Lecture 2015.
abstract: Purkinje fibers/cells continue to be a focus of arrhythmologists. Here we review several new ideas that have emerged in the literature and fold them into important new points. These points include the following: some proteins in Purkinje cells are specific to Purkinjes; pacemaker function in Purkinje may be similar to that of the sinus node cell; sink-source concerns about tracts/sheets of Purkinje fibers; role of Ito in arrhythmias; and genetic lesions in Purkinjes and their high impact on cardiac rhythm. Although new ideas about the remodeled Purkinje cell are not the focus of this review, one can easily imagine how Purkinjes and their function may be altered in diseased hearts.
authors.affiliation: Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, New York.
authors.forename: Penelope A
authors.initials: PA
authors.lastname: Boyden
authors.affiliation: Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, New York.
authors.forename: Wen
authors.initials: W
authors.lastname: Dun
authors.affiliation: Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, New York.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Robinson
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D022062:Electrophysiologic Techniques, Cardiac; D055724:Electrophysiological Phenomena; D006801:Humans; D032383:Myocytes, Cardiac / Q000502:physiology; D011690:Purkinje Fibers / Q000502:physiology / Q000503:physiopathology
keywords: Arrhythmias; Calcium; Ion channels; Pacemaker activity; Purkinje