title: PKM2 released by neutrophils at wound site facilitates early wound healing by promoting angiogenesis.
abstract: Neutrophils infiltration/activation following wound induction marks the early inflammatory response in wound repair. However, the role of the infiltrated/activated neutrophils in tissue regeneration/proliferation during wound repair is not well understood. Here, we report that infiltrated/activated neutrophils at wound site release pyruvate kinase M2 (PKM2) by its secretive mechanisms during early stages of wound repair. The released extracellular PKM2 facilitates early wound healing by promoting angiogenesis at wound site. Our studies reveal a new and important molecular linker between the early inflammatory response and proliferation phase in tissue repair process.
authors.affiliation: Department of Biology, Georgia State University, Atlanta, Georgia.
authors.forename: Yinwei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Biology, Georgia State University, Atlanta, Georgia.
authors.forename: Liangwei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Biology, Georgia State University, Atlanta, Georgia.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Biology, Georgia State University, Atlanta, Georgia.
authors.forename: Zhi-Ren
authors.initials: ZR
authors.lastname: Liu
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000473:pathology; D007150:Immunohistochemistry; D007249:Inflammation / Q000201:enzymology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018919:Neovascularization, Physiologic; D009504:Neutrophils / Q000201:enzymology / Q000378:metabolism*; D011770:Pyruvate Kinase / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000201:enzymology* / Q000473:pathology*
chemical_list: D011770:Pyruvate Kinase