title: [A Case of Gastric Cancer with Multiple Liver Metastases Treated with XP Chemotherapy and RFA Resulting in a Complete Response for a Long Time].
abstract: A 60-year-old man underwent total gastrectomy with Japanese D2 lymph node dissection for advanced gastric cancer. The resected specimen was diagnosed as well-differentiated tubular carcinoma, pT3, pN1, cM0, and the final stage was considered as ⅡB. During adjuvant chemotherapy with S-1 (120 mg/day, administered for 4 weeks and then stopped for 2 weeks), multiple liver metastases were detected by contrast-enhanced CT images 6 months after the operation. Eight courses of XP therapy (capecitabine 1,600 mg/m2/day: day 1-14, cisplatin 70 mg/m2/day: day 1, then stopped until days 15-21) were administered in consideration of the recurrence during adjuvant chemotherapy with S-1, resulting in a partial response. Adverse events such as grade 1-2 abdominal pain, general fatigue, and the resultant deterioration of ADL led to discontinuation of chemotherapy. The residual liver metastasis was treated with RFA therapy, causing it to disappear completely. Serum CEA level was 5.5 ng/mL postoperatively, elevated to 13.9 ng/mL at the time of recurrence and 2.4 ng/mL after XP and RFA therapy. He is doing well without any recurrence 2 years and 6 months later.
authors.affiliation: Dept. of Surgery, Itami City Hospital.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Katsuyama
authors.forename: Masaru
authors.initials: M
authors.lastname: Murata
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tanaka
authors.forename: Kensuke
authors.initials: K
authors.lastname: Asai
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Saso
authors.forename: Moyuru
authors.initials: M
authors.lastname: Yamada
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yagi
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Sawami
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Osamu
authors.initials: O
authors.lastname: Takayama
authors.forename: Masashi
authors.initials: M
authors.lastname: Baba
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiratsuka
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000069287:Capecitabine / Q000008:administration & dosage; D017115:Catheter Ablation; D002945:Cisplatin / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000473:pathology* / Q000628:therapy*; D013997:Time Factors
chemical_list: D000069287:Capecitabine; D002945:Cisplatin