title: [An Evaluation of Outcome of Surgical Treatment for Recurrence after Curative Pancreatectomy for Pancreatic Ductal Cancer].
abstract: The aim of this study was to evaluate the outcome of surgical treatment for recurrence after curative pancreatectomy for pancreatic ductal cancer. Ten cases were enrolled, and the time from initial pancreatectomy to recurrence, location of recurrence, and outcome after surgical treatment for recurrence was evaluated. The time to recurrence was more than 1 year in 4 cases, and the locations of recurrence in these cases were the remnant pancreas and lung in 3 and 1 patients, respectively. Among these 4 cases, a second recurrence was observed in only 1 case, and survival after surgical treatment of the first recurrent site was more than 3 years in the other 3 cases. For the remaining 6 cases, the time to recurrence was less than 1 year and the recurrences were located in the abdomen but not in the remnant pancreas. A second recurrence was observed in all cases, and the survival time was less than 2 years in 4 out of 6 cases. Based on the results of this study, recurrence in the remnant pancreas and lung after curative resection for pancreatic ductal cancer could be a potential indication for surgical treatment.
authors.affiliation: Dept. of Surgery, National Hospital Organization Osaka National Hospital.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyamoto
authors.forename: Sakae
authors.initials: S
authors.lastname: Maeda
authors.forename: Naoki
authors.initials: N
authors.lastname: Hama
authors.forename: Naotsugu
authors.initials: N
authors.lastname: Haraguchi
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Masakazu
authors.initials: M
authors.lastname: Miyake
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Omiya
authors.forename: Michihiko
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Masataka
authors.initials: M
authors.lastname: Ikeda
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hirao
authors.forename: Koji
authors.initials: K
authors.lastname: Takami
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Sekimoto
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakamori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: C117307:KRAS protein, human; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D016283:Proto-Oncogene Proteins p21(ras)