title: Serum miR-132 is a risk marker of post-stroke cognitive impairment.
abstract: OBJECTIVE
  Recently, it has been reported that the microRNA-132(miR-132) is linked with synaptic plasticity and cognitive impairment. The present study investigates that whether miR-132 is altered in circulating blood serum samples of post-stroke cognitive impairment (PSCI) patients.
  
  
  METHODS
  We collected samples from 39 subjects with PSCI, 37 subjects with post-stroke cognitive normality (PSCN), and 38 age-matched controls (AMC) for which ages, gender and education level were matched. MiR-132 was detected using a quantitative real-time PCR (qRT-PCR) method. To test the predictive value of miR-132 for PSCI, prediction capabilities were compared using the receiver operating characteristic (ROC) curves and area under curve (AUC) analysis.
  
  
  RESULTS
  The level of miR-132 in PSCI patient serum was significantly elevated compared to that of PSCN and AMC subjects. The ROC curve showed that miR-132 achieved an AUC of 0.961 (p<0.0001). Importantly, the miR-132 level was correlated with the Montreal Cognitive Assessment (MoCA) score in PSCI patients.
  
  
  CONCLUSIONS
  These results indicated that there was a substantial correlation between serum miR-132 expression and post-stroke cognitive functionality, suggesting that miR-132 may be a risk marker for PSCI. Because of the limitations of this study, the results should be treated with caution.
authors.affiliation: Department of Rehabilitation Medicine, Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fujian 350003, China.
authors.forename: Sai'e
authors.initials: S
authors.lastname: Huang
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fujian 350122, China.
authors.forename: Jiapei
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fujian 350122, China.
authors.forename: Danxia
authors.initials: D
authors.lastname: Huang
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fujian 350122, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhuo
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fujian 350122, China.
authors.forename: Shaoqin
authors.initials: S
authors.lastname: Liao
authors.affiliation: Fujian University of Traditional Chinese Medicine, 1Qiuyang Road, Minhou Shangjie, Fuzhou, Fujian 350122, China. Electronic address: sunshine11shine@163.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003072:Cognition Disorders / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D012306:Risk; D020521:Stroke / Q000097:blood* / Q000150:complications
chemical_list: D015415:Biomarkers; C547077:MIRN132 microRNA, human; D035683:MicroRNAs
keywords: Post stroke cognitive impairment; Serum; miR-132