title: Adverse events in apheresis: An update of the WAA registry data.
abstract: Apheresis with different procedures and devices are used for a variety of indications that may have different adverse events (AEs). The aim of this study was to clarify the extent and possible reasons of various side effects based on data from a multinational registry. The WAA-apheresis registry data focus on adverse events in a total of 50846 procedures in 7142 patients (42% women). AEs were graded as mild, moderate (need for medication), severe (interruption due to the AE) or death (due to AE). More AEs occurred during the first procedures versus subsequent (8.4 and 5.5%, respectively). AEs were mild in 2.4% (due to access 54%, device 7%, hypotension 15%, tingling 8%), moderate in 3% (tingling 58%, urticaria 15%, hypotension 10%, nausea 3%), and severe in 0.4% of procedures (syncope/hypotension 32%, urticaria 17%, chills/fever 8%, arrhythmia/asystole 4.5%, nausea/vomiting 4%). Hypotension was most common if albumin was used as the replacement fluid, and urticaria when plasma was used. Arrhythmia occurred to similar extents when using plasma or albumin as replacement. In 64% of procedures with bronchospasm, plasma was part of the replacement fluid used. Severe AEs are rare. Although most reactions are mild and moderate, several side effects may be critical for the patient. We present side effects in relation to the procedures and suggest that safety is increased by regular vital sign measurements, cardiac monitoring and by having emergency equipment nearby.
authors.affiliation: Nephrol, Umeå, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Mörtzell Henriksson
authors.affiliation: Bone Marrow Transplant & Apheresis, New South Wales, Australia.
authors.forename: E
authors.initials: E
authors.lastname: Newman
authors.affiliation: St. Anna, Vienna, Austria.
authors.forename: V
authors.initials: V
authors.lastname: Witt
authors.affiliation: AKH, Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Derfler
authors.affiliation: AKH, Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Leitner
authors.affiliation: Gent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Eloot
authors.affiliation: Gent, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Dhondt
authors.affiliation: Roeselar, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Deeren
authors.affiliation: Canada.
authors.forename: G
authors.initials: G
authors.lastname: Rock
authors.affiliation: Frydek-Mistek, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Ptak
authors.affiliation: Hradec Kralove, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Blaha
authors.affiliation: Hradec Kralove, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Lanska
authors.affiliation: Prague, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Gasova
authors.affiliation: Ostrava, Czech Republic.
authors.forename: R
authors.initials: R
authors.lastname: Hrdlickova
authors.affiliation: Rostock, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Ramlow
authors.affiliation: Rostock, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Prophet
authors.affiliation: Livorno, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Liumbruno
authors.affiliation: Livorno, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Mori
authors.affiliation: Vilnius, Lithuania.
authors.forename: A
authors.initials: A
authors.lastname: Griskevicius
authors.affiliation: Vilnius, Lithuania.
authors.forename: J
authors.initials: J
authors.lastname: Audzijoniene
authors.affiliation: Amsterdam, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Vrielink
authors.affiliation: Maastricht, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Rombout
authors.affiliation: Oslo, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Aandahl
authors.affiliation: Skopje, Macedonia.
authors.forename: A
authors.initials: A
authors.lastname: Sikole
authors.affiliation: Coimbra, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Tomaz
authors.affiliation: Belgrade, Serbia.
authors.forename: K
authors.initials: K
authors.lastname: Lalic
authors.affiliation: Zagreb, Croatia.
authors.forename: S
authors.initials: S
authors.lastname: Mazic
authors.affiliation: Orebro, Sweden.
authors.forename: V
authors.initials: V
authors.lastname: Strineholm
authors.affiliation: Huddinge, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Brink
authors.affiliation: Linköping, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Berlin
authors.affiliation: Lund, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Dykes
authors.affiliation: BC, Umea, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Toss
authors.affiliation: BC, Umea, Sweden.
authors.forename: C G
authors.initials: CG
authors.lastname: Axelsson
authors.affiliation: Nephrol, Umeå, Sweden. Electronic address: bernd.stegmayr@umu.se.
authors.forename: B
authors.initials: B
authors.lastname: Stegmayr
authors.affiliation: Nephrol, Uppsala, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Nilsson
authors.affiliation: BC, Uppsala, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Norda
authors.affiliation: BC, Uppsala, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Knutson
authors.affiliation: Nephrol., Skövde, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Ramsauer
authors.affiliation: Nephrol., Karlstad, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Wahlström
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001781:Blood Component Removal / Q000009:adverse effects*; D002118:Calcium / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003102:Colloids; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange; D012015:Reference Standards; D012042:Registries; D012955:Societies, Medical; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003102:Colloids; D002118:Calcium
keywords: Adverse events; Albumin; Apheresis; Donor; Plasma