title: Thyroid Disease and Oral Lichen Planus as Comorbidity: A Prospective Case-Control Study.
abstract: BACKGROUND
  Thyroid disease has been mentioned to have a possible relation to the development of oral lichen planus (OLP).
  
  
  OBJECTIVE
  Because goiter is considered endemic in many countries, we proposed to determine whether thyroid disease constitutes a comorbidity of OLP.
  
  
  METHODS
  Two hundred and fifteen patients diagnosed as having OLP were evaluated concerning their serum thyroid-stimulating hormone and thyroxine (T4) levels. The results were contrasted with those obtained in control series of the same number of subjects matched for age and sex.
  
  
  RESULTS
  Diagnosis of thyroid disease was present in 15.3% of OLP patients (33/215) and in 5.2% (12/215) of the control group. In relation to OLP patients, the odds ratio of presence of thyroid disorders was 3.06 and that of using levothyroxine medication 3.21.
  
  
  CONCLUSIONS
  In the present study, OLP patients were associated with thyroid disease, specifically with hypothyroidism. Because most thyroid patients need T4 treatment, our findings confirmed that OLP and thyroid disease could be comorbidities.
authors.affiliation: Faculty of Medicine, University of Oviedo, Oviedo, Spain.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Garcia-Pola
authors.forename: Santiago
authors.initials: S
authors.lastname: Llorente-Pendás
authors.forename: Juan M
authors.initials: JM
authors.lastname: Seoane-Romero
authors.forename: Maria Jesus
authors.initials: MJ
authors.lastname: Berasaluce
authors.forename: José Manuel
authors.initials: JM
authors.lastname: García-Martín
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000097:blood* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology; D013959:Thyroid Diseases / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D013972:Thyrotropin; D013974:Thyroxine