title: The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system.
abstract: The Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway is a major signaling pathway in the central nervous system, transducing inhibitory signals to block regeneration. After central nervous system damage, the main cause of impaired regeneration is the presence of factors that strongly inhibit regeneration in the surrounding microenvironment. These factors signal through the Rho/ROCK signaling pathway to inhibit regeneration. Therefore, a thorough understanding of the Rho/ROCK signaling pathway is crucial for advancing studies on regeneration and repair of the injured central nervous system.
authors.affiliation: Department of Neonatology & NICU of Bayi Children's Hospital, General Hospital of Beijing Military Command of Chinese PLA, Beijing, China.
authors.forename: Jing
authors.identifier: 0000-0001-8356-9515
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neonatology & NICU of Bayi Children's Hospital, General Hospital of Beijing Military Command of Chinese PLA, Beijing, China.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Gao
authors.affiliation: Department of Neonatology & NICU of Bayi Children's Hospital, General Hospital of Beijing Military Command of Chinese PLA, Beijing, China; Department of Neonatology, People's Hospital of Rizhao, Rizhao, Shangdong Province, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wang
keywords: NSFC grant; Rho/Rho-associated coiled-coil containing protein kinase; axonal regeneration; central nervous system; microenvironment; nerve regeneration; neural regeneration; reviews; signaling pathway