title: Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis.
abstract: OBJECTIVE
  Osteoporosis contributes to impaired bone regeneration and remodeling through an imbalance of osteoblastic and osteoclastic activity, and can delay peri-implant bone formation after dental implant surgery, resulting in a prolonged treatment period. It poses several difficulties for individuals with large edentulous areas, and decreases their quality of life. Consequently, prompt postoperative placement of the final prosthesis is very important clinically. Peri-implant bone formation may be enhanced by systemic approaches, such as the use of osteoporosis supplements, to promote bone metabolism. We aimed to confirm whether intake of synthetic bone mineral (SBM), a supplement developed for osteoporosis, could effectively accelerate peri-implant bone formation in a rat model of osteoporosis.
  
  
  METHODS
  Thirty-six 7-week-old ovariectomized female Wistar rats were randomly assigned to receive a standardized diet with or without SBM (Diet with SBM group and Diet without SBM group, respectively; n=18 for both). The rats underwent implant surgery at 9 weeks of age under general anesthesia. The main outcome measures, bone mineral density (BMD) and pull-out strength of the implant from the femur, were compared at 2 and 4 weeks after implantation using the Mann-Whitney U test.
  
  
  RESULTS
  Pull-out strength and BMD in the Diet with SBM group were significantly greater than those in the Diet without SBM group at 2 and 4 weeks after implantation.
  
  
  CONCLUSIONS
  This study demonstrated that SBM could be effective in accelerating peri-implant bone formation in osteoporosis.
authors.affiliation: Nihon University Graduate School of Dentistry at Matsudo, Removable Prosthodontics, Matsudo, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Japan. Electronic address: takehiro.watanabe1018@gmail.com.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakada
authors.affiliation: Department of Dental Biomaterials, Nihon University of Dentistry at Matsudo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tanimoto
authors.affiliation: Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Japan.
authors.forename: Suguru
authors.initials: S
authors.lastname: Kimoto
authors.affiliation: Department of Biomaterials & Biomimetics, New York University College of Dentistry, USA.
authors.forename: Dindo Q
authors.initials: DQ
authors.lastname: Mijares
authors.affiliation: Department of Biomaterials & Biomimetics, New York University College of Dentistry, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kawai
mesh_terms: D000818:Animals; D015519:Bone Density; D003757:Dental Implantation; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005260:Female; D008903:Minerals / Q000008:administration & dosage*; D010012:Osteogenesis; D010024:Osteoporosis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008903:Minerals
keywords: Animal study; Bone formation; Implant; Supplement