title: Synthesis of some new porphyrins and their metalloderivatives as potential sensitizers in photo-dynamic therapy.
abstract: Porphyrins are a ubiquitous large class of naturally occurring macrocyclic compounds with many significant biological representatives comprising heme and chlorophyll. Some novel adaptable methods for the synthesis of free-based porphyrins as promising sensitizers for the use in photo-dynamic therapy by the virtue of their known tumor affinity, low dark cytotoxicity, and easy synthesis in good to high yields have already been discussed. In the present study, two new porphyrins including TAPFA, as a novel folic acid targeted porphyrin sensitizer, and TAP-Schiff base, as a novel sensitizer with better light absorption, were prepared for the first time and their structures were confirmed by (1)H NMR, (13)C NMR, FT-IR and UV-Vis spectroscopy as well as CHNS analysis. The compounds were metalized with Zn(II) and Fe(II) metal ions to study how the metal ions can improve the light absorption wavelength and their water solubility. The structures of metalized compounds were also confirmed by FT-IR and UV-Vis spectroscopy.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
authors.forename: Mahboubeh
authors.initials: M
authors.lastname: Rostami
authors.affiliation: Department of Chemistry, Faculty of Science, Urmia University, Urmia 57153, I.R. Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Rafiee
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Hassanzadeh
authors.affiliation: Department of Chemistry, Faculty of Science, Urmia University, Urmia 57153, I.R. Iran.
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Dadrass
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
authors.forename: Ghadam Ali
authors.initials: GA
authors.lastname: Khodarahmi
keywords: Metalloporphyrins; Photo-dynamic therapy (PDT); Porphyrins; Two-photon absorption (TPA)