title: Differential diagnosis of squamous cell carcinoma in situ using skin histopathological images.
abstract: Differential diagnosis of squamous cell carcinoma in situ is of great importance for prognosis and decision making in the disease treatment procedure. Currently, differential diagnosis is done by pathologists based on examination of the histopathological slides under the microscope, which is time consuming and prone to inter and intra observer variability. In this paper, we have proposed an automated method for differential diagnosis of SCC in situ from actinic keratosis, which is known to be a precursor of squamous cell carcinoma. The process begins with epidermis segmentation and cornified layer removal. Then, epidermis axis is specified using the paths in its skeleton and the granular layer is removed via connected components analysis. Finally, diagnosis is done based on the classification result of intensity profiles extracted from lines perpendicular to the epidermis axis. The results of the study are in agreement with the gold standards provided by expert pathologists.
authors.affiliation: Department of Computer Engineering and Science, Shahid Beheshti University, Tehran, Iran. Electronic address: n_noroozi@sbu.ac.ir.
authors.forename: Navid
authors.initials: N
authors.lastname: Noroozi
authors.affiliation: Department of Computer Engineering and Science, Shahid Beheshti University, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Zakerolhosseini
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
keywords: Actinic keratosis; Classification; Cutaneous squamous cell carcinoma; Differential diagnosis; Skin cancer