title: [Intraductal carcinoma of the prostate].
abstract: For many tumor entities, especially in breast cancer, an intraductal carcinoma is generally perceived as a precursor lesion, which precedes the emergence of invasive carcinoma. Therefore, in addition to parameters of the invasive carcinoma, histological parameters of the intraductal component have always played an important role in therapy planning of breast cancer. This is different in prostate cancer and although the term "intraductal carcinoma" has long been propagated by some authors, its routine use remains rare and inconsistent. This is certainly not only due to the far simpler therapy options of prostate cancer, in which focal and organ-preserving therapies still play a subordinate role, but also due to substantial interobserver variation and our inconsistent perception of intraductal carcinomas. This article gives a brief overview of currently available literature on this topic and explains why intraductal carcinoma of the prostate deserves our attention. In contrast to breast cancer, intraductal carcinoma of the prostate usually represents a post-invasive lesion, in which an aggressive tumor exhibits spread into pre-existing ducts; however, in rare cases, intraductal carcinoma may represent a true precursor lesion.
authors.affiliation: Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, Gebäude 329, 53127, Bonn, Deutschland. glen.kristiansen@ukb.uni-bonn.de.
authors.forename: G
authors.initials: G
authors.lastname: Kristiansen
authors.affiliation: Department of Histopathology, University Hospital of Wales, Cardiff, UK.
authors.forename: M
authors.initials: M
authors.lastname: Varma
authors.affiliation: Gemeinschaftspraxis für Pathologie am Klinikum Bamberg, Bamberg, Deutschland.
authors.forename: G
authors.initials: G
authors.lastname: Seitz
mesh_terms: D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D015588:Observer Variation; D011230:Precancerous Conditions / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy
keywords: Diagnostic criteria; Interobserver variation; Postinvasive lesion; Precursor lesion; Therapy options