title: Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype.
abstract: Primary hepatic peripheral T-cell lymphoma (PTCL) is exceedingly rare. We encountered such a case in a 58-year-old Hispanic female with a history of chronic sinusitis and hypothyroidism who presented with 4weeks of fever and weight loss. Laboratory studies showed altered liver function and mild pancytopenia. Hepatitis and HIV infection were excluded by negative serological tests. A computed tomography (CT) scan showed innumerable small low-density lesions throughout the liver without splenomegaly or lymphadenopathy. CT-guided liver core biopsy showed scattered small lymphoid aggregates located mainly in the portal tracts and periportal regions. Within the lymphoid aggregates, scattered large pleomorphic lymphoma cells were seen, admixed with smaller lymphoid cells and histiocytes. By immunohistochemistry, the lymphoma cells expressed CD2, CD3, CD8, CD30, CD43, CD45, granzyme B, TIA-1, and negative for CD4, CD5, CD7, CD56, βF1, ALK-1, and B-cell markers. In situ hybridization for Epstein-Barr virus-encoded RNA (EBER) was positive in some lymphoma cells. To our knowledge, this is the first reported case of primary hepatic Epstein-Barr virus-associated PTCL with CD30 expression.
authors.affiliation: Department of Pathology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90502, USA.
authors.forename: Yue
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Terasaki Research Institute, Los Angeles, CA, USA.
authors.forename: Junchao
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Pathology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90502, USA.
authors.forename: Changjun
authors.initials: C
authors.lastname: Yue
authors.affiliation: Department of Pathology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90502, USA. Electronic address: drqingx@yahoo.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Qing
mesh_terms: D001402:B-Lymphocytes / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000473:pathology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D017730:Ki-1 Antigen / Q000276:immunology; D007694:Killer Cells, Natural / Q000378:metabolism; D016411:Lymphoma, T-Cell, Peripheral / Q000276:immunology / Q000821:virology*; D008875:Middle Aged; D010641:Phenotype; D013602:T-Lymphocytes, Cytotoxic
chemical_list: D017730:Ki-1 Antigen
keywords: CD30; Cytotoxic; Epstein–Barr virus; Peripheral T-cell lymphoma; Primary hepatic lymphoma; Primary liver lymphoma