title: Screening of celiac disease in children with Henoch-Schoenlein purpura.
abstract: Prevalence of celiac disease (CD) is 2.42 % in healthy Turkish children. The frequency of IgA-associated disorders is increased in CD. Henoch-Schoenlein purpura (HSP) is an IgA-associated vasculitis. Association of HSP with CD has not been evaluated. We aimed to evaluate whether CD prevalence is increased in children with HSP. Children with HSP were evaluated for demographic, anthropometric, clinical, and laboratory data including urinalysis, complete blood count, albumin, creatinine, and IgA levels. In addition, tTG-IgA, EMA-IgA, anti-DGP-IgA, and IgG antibody levels were measured. Seropositive patients were evaluated by endoscopic small bowel biopsy. The rate of CD seropositivity and confirmed CD in HSP patients was compared to the rate in healthy Turkish children. There were 42 children (25 male) with HSP. No patient had classical CD symptoms, but two patients had growth failure. None of them had IgA deficiency, anemia or hypoalbuminemia. Celiac serology was positive in five (12 %) children. Endoscopic evaluation was performed in four patients, and two (5 %) of them were confirmed to have CD. Prevalence of both CD seropositivity and histologically confirmed CD in children with HSP was significantly higher compared to healthy Turkish children (p < 0.001 and p = 0.019, respectively). CD seropositivity rate in children with HSP (12 %) is significantly higher than the rate in healthy children. Although the number of children with HSP is small in this preliminary study, this result suggests that celiac screening may be considered in children with HSP.
authors.affiliation: Division of Nephrology, Department of Pediatrics, Dokuz Eylül University Medical Faculty, 35340, Balcova, Izmir, Turkey. alper.soylu@deu.edu.tr.
authors.forename: Alper
authors.initials: A
authors.lastname: Soylu
authors.affiliation: Division of Nephrology, Department of Pediatrics, Dokuz Eylül University Medical Faculty, 35340, Balcova, Izmir, Turkey.
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Öztürk
authors.affiliation: Department of Microbiology, Dokuz Eylül University Medical Faculty, Izmir, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Doğan
authors.affiliation: Division of Nephrology, Department of Pediatrics, Dokuz Eylül University Medical Faculty, 35340, Balcova, Izmir, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Özmen
authors.affiliation: Department of Microbiology, Dokuz Eylül University Medical Faculty, Izmir, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Yılmaz
authors.affiliation: Division of Nephrology, Department of Pediatrics, Dokuz Eylül University Medical Faculty, 35340, Balcova, Izmir, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Kuyum
authors.affiliation: Division of Nephrology, Department of Pediatrics, Dokuz Eylül University Medical Faculty, 35340, Balcova, Izmir, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Kavukçu
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000276:immunology; D008297:Male; D014421:Turkey
chemical_list: D001323:Autoantibodies
keywords: Anti-endomysium IgA; Anti-tissue transglutaminase IgA; Celiac disease; Henoch-Schoenlein purpura