title: Relation between sex hormones and hepatocellular carcinoma.
abstract: Males have higher incidence of hepatocellular carcinoma (HCC) than females. Sex hormones may be a risk factor. The aim was to determine the levels of sex hormones in male and female patients with HCC and cirrhosis versus controls and its possible relationship with HCC. This study was conducted on 90 subjects divided into 40 patients with HCC, 30 patients with liver cirrhosis and 20 apparently healthy subjects complete blood picture, liver function tests. Determination of AFP levels and hormonal assay of oestrogen, progesterone, total testosterone, prolactin, FSH and LH were performed on all subjects. Total testosterone levels were significantly decreased in the two patients groups compared with controls. While oestrogen levels were significantly decreased in the HCC group in comparison with other two groups, prolactin levels were significantly decreased in the HCC group compared with the liver cirrhosis group and increased in the liver cirrhosis group when compared to controls. FSH and LH levels were significantly increased in the HCC group when compared to controls. There is no significant correlation between sex hormones assay and both the size of HCC and degree of cirrhosis in both patient groups. It is concluded that there is no strong relation between sex hormones and HCC when the study was carried out on the levels of sex hormones in patients with HCC.
authors.affiliation: Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt.
authors.forename: T
authors.initials: T
authors.lastname: El Mahdy Korah
authors.affiliation: Medical Biochemistry Department, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt. ebadr2014@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Abd Elfatah Badr
authors.affiliation: Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Mohamed Emara
authors.affiliation: National Liver Institute, Menoufia University, Shebin ElKom, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Ahmed Samy Kohla
authors.affiliation: Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt.
authors.forename: G
authors.initials: G
authors.lastname: Gamal Saad Michael
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology*; D016022:Case-Control Studies; D004534:Egypt; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000209:etiology; D008113:Liver Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: C097353:AFP protein, human; D012739:Gonadal Steroid Hormones; D000509:alpha-Fetoproteins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Follicle-stimulating hormone; hepatocellular carcinoma; liver cirrhosis; luteinising hormone; oestrogen; progesterone; prolactin; sex hormone; testosterone