title: Altered functional connectivity density in high myopia.
abstract: Abnormal visual experience can affect the brain structure and function. Visual functional performances of high myopia (HM) individuals were observed to be abnormal in contrast to emmetropics, even with a corrected visual acuity. Attention deficits and brain morphological changes have been revealed in the HM, but it is unknown whether there are functional connectivity (FC) alterations. The current study combined the resting-state functional connectivity density (FCD) mapping and seed-based correlation analysis to investigate FC alterations in the brain of HM. In our results, the HM exhibited decreased short- and long-range FCD in the posterior cingulate cortex/precuneus and decreased long-range FCD in the inferior temporal gyrus, supramarginal gyrus and rostrolateral prefrontal cortex. Specially, long-range FCD in the rostrolateral prefrontal cortex showed a significant positive correlation with the uncorrected visual acuity in the HM. Moreover, the HM showed significantly decreased FC not only between the supramarginal gyrus and rostrolateral prefrontal cortex, but also between networks they belong to, the ventral attention and frontoparietal control networks. These results provide evidence for the FC changes in the HM and may help to understand the attention deficits in myopes.
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin 300203, PR China.
authors.forename: Liying
authors.initials: L
authors.lastname: Zhai
authors.affiliation: Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin 300203, PR China.
authors.forename: Tianyue
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Magnetic Resonance, Cangzhou Central Hospital, Hebei 061001, PR China.
authors.forename: HongHuan
authors.initials: H
authors.lastname: Dong
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin 300203, PR China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Peng
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin 300203, PR China. Electronic address: guomx11@163.com.
authors.forename: Mingxia
authors.initials: M
authors.lastname: Guo
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Qin
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin 300203, PR China; Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, PR China.
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009216:Myopia / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D055815:Young Adult
keywords: Attention; Functional connectivity density; Functional magnetic resonance imaging; High myopia; Rostrolateral prefrontal cortex