title: INVITED REVIEW--IMAGE REGISTRATION IN VETERINARY RADIATION ONCOLOGY: INDICATIONS, IMPLICATIONS, AND FUTURE ADVANCES.
abstract: The field of veterinary radiation therapy (RT) has gained substantial momentum in recent decades with significant advances in conformal treatment planning, image-guided radiation therapy (IGRT), and intensity-modulated (IMRT) techniques. At the root of these advancements lie improvements in tumor imaging, image alignment (registration), target volume delineation, and identification of critical structures. Image registration has been widely used to combine information from multimodality images such as computerized tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) to improve the accuracy of radiation delivery and reliably identify tumor-bearing areas. Many different techniques have been applied in image registration. This review provides an overview of medical image registration in RT and its applications in veterinary oncology. A summary of the most commonly used approaches in human and veterinary medicine is presented along with their current use in IGRT and adaptive radiation therapy (ART). It is important to realize that registration does not guarantee that target volumes, such as the gross tumor volume (GTV), are correctly identified on the image being registered, as limitations unique to registration algorithms exist. Research involving novel registration frameworks for automatic segmentation of tumor volumes is ongoing and comparative oncology programs offer a unique opportunity to test the efficacy of proposed algorithms.
authors.affiliation: Department of Oncology Physics, Edinburgh Cancer Centre, Western General Hospital, The University of Edinburgh, Edinburgh, UK.|Royal (Dick) School of Veterinary Studies and Roslin Institute, The University of Edinburgh, Edinburgh, UK.|Healthcare Department, Philips Research China, Shanghai, 200233, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Royal (Dick) School of Veterinary Studies and Roslin Institute, The University of Edinburgh, Edinburgh, UK.
authors.forename: Jessica
authors.initials: J
authors.lastname: Lawrence
authors.affiliation: Department of Oncology Physics, Edinburgh Cancer Centre, Western General Hospital, The University of Edinburgh, Edinburgh, UK.
authors.forename: Kun
authors.initials: K
authors.lastname: Cheng
authors.affiliation: Department of Oncology Physics, Edinburgh Cancer Centre, Western General Hospital, The University of Edinburgh, Edinburgh, UK.
authors.forename: Dean
authors.initials: D
authors.lastname: Montgomery
authors.affiliation: Department of Surgical Sciences, The University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI.
authors.forename: Lisa
authors.initials: L
authors.lastname: Forrest
authors.affiliation: Department of Oncology Physics, Edinburgh Cancer Centre, Western General Hospital, The University of Edinburgh, Edinburgh, UK.
authors.forename: Duncan B
authors.initials: DB
authors.lastname: Mclaren
authors.affiliation: School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: McLaughlin
authors.affiliation: Royal (Dick) School of Veterinary Studies and Roslin Institute, The University of Edinburgh, Edinburgh, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Argyle
authors.affiliation: Department of Oncology Physics, Edinburgh Cancer Centre, Western General Hospital, The University of Edinburgh, Edinburgh, UK.
authors.forename: William H
authors.initials: WH
authors.lastname: Nailon
mesh_terms: D000820:Animal Diseases / Q000000981:diagnostic imaging*; D000818:Animals; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000662:veterinary; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000662:veterinary*; D049268:Positron-Emission Tomography / Q000379:methods / Q000662:veterinary; D018787:Radiation Oncology / Q000295:instrumentation / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000295:instrumentation / Q000379:methods / Q000662:veterinary*; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000662:veterinary
keywords: computed tomography; image registration; magnetic resonance imaging; oncology; radiation therapy