title: Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population.
abstract: Background. Parkinson's disease (PD) and Alzheimer's disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. Methods. The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study. Results. We found an association of rs638405 in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD.
authors.affiliation: The Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, Norway.
authors.forename: Johannes
authors.initials: J
authors.lastname: Lange
authors.affiliation: The Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, Norway; Centre for Organelle Research, University of Stavanger, 4036 Stavanger, Norway.
authors.forename: Kristin Aaser
authors.initials: KA
authors.lastname: Lunde
authors.affiliation: Centre for Organelle Research, University of Stavanger, 4036 Stavanger, Norway.
authors.forename: Camilla
authors.initials: C
authors.lastname: Sletten
authors.affiliation: Department of Biological Sciences, St. John's University, New York, NY 11439, USA.
authors.forename: Simon Geir
authors.initials: SG
authors.lastname: Møller
authors.affiliation: Department of Neurology, Haukeland University Hospital, 5021 Bergen, Norway; Institute for Clinical Medicine, University of Bergen, 5021 Bergen, Norway.
authors.forename: Ole-Bjørn
authors.initials: OB
authors.lastname: Tysnes
authors.affiliation: The Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, Norway; Department of Neurology, Stavanger University Hospital, 4011 Stavanger, Norway.
authors.forename: Guido
authors.initials: G
authors.lastname: Alves
authors.affiliation: The Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, Norway.
authors.forename: Jan Petter
authors.initials: JP
authors.lastname: Larsen
authors.affiliation: The Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, Norway; Centre for Organelle Research, University of Stavanger, 4036 Stavanger, Norway.
authors.forename: Jodi
authors.initials: J
authors.lastname: Maple-Grødem