title: Interactions between retinol, α-tocopherol and cholecalciferol need consideration in diets for farmed mink (Mustela vison).
abstract: A sufficient but balanced vitamin supplementation is a prerequisite for a satisfactory growth pattern and an effective immune system in mink and all other species. The fat-soluble vitamins are very sensitive to over- or under-supply because they interact with each other with respect to dose-response and chemical form. The purpose of the present study was to investigate the effect of increasing the amount of retinol in combination with RRR-α-tocopherol or all-rac-α-tocopherol in the feed given to growing mink on their retinol, cholecalciferol and α-tocopherol concentrations in plasma and selected organs. The results showed that the mink met their retinol requirements from the basal diet, but there were no negative effects of supplying various amounts of retinol on their plasma α-tocopherol concentrations. On the other hand, the study showed that the cholecalciferol status in plasma, assessed as the 25-hydroxycholecalciferol concentration, was low when retinol was supplemented in the feed at high levels. In addition, supplementation with RRR-α-tocopherol in the feed negatively affected the plasma concentration of 25-hydroxycholecalciferol compared with supplementation with all-rac-α-tocopherol. In general, female mink had higher concentrations of fat-soluble vitamins in plasma than male mink.
authors.affiliation: 1Department of Animal Science,Aarhus University,Blichers Allé 20,DK-8830 Tjele,Denmark.
authors.forename: Lone
authors.initials: L
authors.lastname: Hymøller
authors.affiliation: 2Copenhagen Fur Research Centre,Herningvej 112 C,DK-7500 Holstebro,Denmark.
authors.forename: Tove N
authors.initials: TN
authors.lastname: Clausen
authors.affiliation: 1Department of Animal Science,Aarhus University,Blichers Allé 20,DK-8830 Tjele,Denmark.
authors.forename: Søren K
authors.initials: SK
authors.lastname: Jensen
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002112:Calcifediol / Q000008:administration & dosage / Q000097:blood; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000097:blood; D004032:Diet / Q000662:veterinary*; D019587:Dietary Supplements; D004347:Drug Interactions; D005260:Female; D008297:Male; D008907:Mink; D014801:Vitamin A / Q000008:administration & dosage* / Q000097:blood; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000097:blood
chemical_list: D014801:Vitamin A; D002762:Cholecalciferol; D024502:alpha-Tocopherol; D002112:Calcifediol
keywords:   α-Tocopherol; 25VD3 25-hydroxycholecalciferol; Cholecalciferol; Fat-soluble vitamins; Interactions; Mink; RET retinol; Retinol; TOC 
                    α-tocopherol; VD3 cholecalciferol