title: Essential proteins and possible therapeutic targets of Wolbachia endosymbiont and development of FiloBase--a comprehensive drug target database for Lymphatic filariasis.
abstract: Lymphatic filariasis (Lf) is one of the oldest and most debilitating tropical diseases. Millions of people are suffering from this prevalent disease. It is estimated to infect over 120 million people in at least 80 nations of the world through the tropical and subtropical regions. More than one billion people are in danger of getting affected with this life-threatening disease. Several studies were suggested its emerging limitations and resistance towards the available drugs and therapeutic targets for Lf. Therefore, better medicine and drug targets are in demand. We took an initiative to identify the essential proteins of Wolbachia endosymbiont of Brugia malayi, which are indispensable for their survival and non-homologous to human host proteins. In this current study, we have used proteome subtractive approach to screen the possible therapeutic targets for wBm. In addition, numerous literatures were mined in the hunt for potential drug targets, drugs, epitopes, crystal structures, and expressed sequence tag (EST) sequences for filarial causing nematodes. Data obtained from our study were presented in a user friendly database named FiloBase. We hope that information stored in this database may be used for further research and drug development process against filariasis. URL: http://filobase.bicpu.edu.in.
authors.affiliation: Centre for Bioinformatics, School of Life Science, Pondicherry University, Pondicherry-605014, India.
authors.forename: Om Prakash
authors.initials: OP
authors.lastname: Sharma
authors.affiliation: Centre for Bioinformatics, School of Life Science, Pondicherry University, Pondicherry-605014, India.
authors.forename: Muthuvel Suresh
authors.initials: MS
authors.lastname: Kumar
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D017178:Brugia malayi / Q000382:microbiology / Q000472:pathogenicity; D030541:Databases, Genetic; D004605:Elephantiasis, Filarial / Q000188:drug therapy / Q000235:genetics* / Q000469:parasitology; D020224:Expressed Sequence Tags; D005786:Gene Expression Regulation / Q000235:genetics; D016680:Genome, Bacterial; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D020543:Proteome / Q000187:drug effects / Q000235:genetics; D017422:Sequence Analysis, DNA; D013559:Symbiosis; D020577:Wolbachia / Q000235:genetics* / Q000472:pathogenicity
chemical_list: D001426:Bacterial Proteins; D020543:Proteome