title: Morphological and Cellular Features of Innate Immune Reaction in Helicobacter pylori Gastritis: A Brief Review.
abstract: Innate and adaptive immunity are both involved in acute and chronic inflammatory processes. The main cellular players in the innate immune system are macrophages, mast cells, dendritic cells, neutrophils, eosinophils, and natural killer (NK), which offer antigen-independent defense against infection. Helicobacter pylori (H. pylori) infection presents peculiar characteristics in gastric mucosa infrequently occurring in other organs; its gastric colonization determines a causal role in both gastric carcinomas and mucosa-associated lymphoid tissue lymphoma. In contrast, an active role for Epstein-Barr virus (EBV) has been identified only in 9% of gastric carcinomas. The aim of the present review is to discuss the role of cellular morphological effectors in innate immunity during H. pylori infection and gastric carcinogenesis.
authors.affiliation: Department of Human Pathology "<i>Gaetano Barresi</i>", University of Messina, Messina 98125, Italy. aieni@unime.it.|Azienda Ospedaliera Universitaria "<i>Policlinico Gaetano Martino</i>", Messina 98125, Italy. aieni@unime.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ieni
authors.affiliation: Department of Human Pathology "<i>Gaetano Barresi</i>", University of Messina, Messina 98125, Italy. vbarresi@unime.it.|Azienda Ospedaliera Universitaria "<i>Policlinico Gaetano Martino</i>", Messina 98125, Italy. vbarresi@unime.it.
authors.forename: Valeria
authors.initials: V
authors.lastname: Barresi
authors.affiliation: Department of Human Pathology "<i>Gaetano Barresi</i>", University of Messina, Messina 98125, Italy. lrigoli@unime.it.|Azienda Ospedaliera Universitaria "<i>Policlinico Gaetano Martino</i>", Messina 98125, Italy. lrigoli@unime.it.
authors.forename: Luciana
authors.initials: L
authors.lastname: Rigoli
authors.affiliation: Azienda Ospedaliera Universitaria "<i>Policlinico Gaetano Martino</i>", Messina 98125, Italy. f.fedele1965@libero.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fedele
authors.affiliation: Department of Human Pathology "<i>Gaetano Barresi</i>", University of Messina, Messina 98125, Italy. tuccari@unime.it.|Azienda Ospedaliera Universitaria "<i>Policlinico Gaetano Martino</i>", Messina 98125, Italy. tuccari@unime.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tuccari
authors.affiliation: Department of Human Pathology "<i>Gaetano Barresi</i>", University of Messina, Messina 98125, Italy. rosariocaruso@tin.it.|Azienda Ospedaliera Universitaria "<i>Policlinico Gaetano Martino</i>", Messina 98125, Italy. rosariocaruso@tin.it.
authors.forename: Rosario Alberto
authors.initials: RA
authors.lastname: Caruso
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000276:immunology / Q000473:pathology; D005756:Gastritis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007113:Immunity, Innate
keywords: Helicobacter pylori; eosinophils; gastritis; innate immunity; mast cell; neutrophils