title: Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions.
abstract: A direct C-H bond phosphonation of quinoxalin-2(1H)-ones with H-phosphonates, H-phosphinates or H-phosphine oxides has been developed. A wide variety of heteroaryl phosphonates were obtained in up to 92% yield for 20 examples under transition-metal-free conditions. This protocol tolerates a broad scope of substrates and features practicality, high efficiency, environmental friendliness and atom economy.
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China. cuixl@hqu.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China. cuixl@hqu.edu.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China. cuixl@hqu.edu.cn.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Xie
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China. cuixl@hqu.edu.cn and CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, BP 44099, F-31077 Toulouse Cedex 4, France and Université de Toulouse, UPS, INPT, F-31077 Toulouse, Cedex 4, France.
authors.forename: Remi
authors.initials: R
authors.lastname: Chauvin
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China. cuixl@hqu.edu.cn.
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui