title: [Association of copy number variation of exon 11 of IL-23 receptor gene with susceptibility to tuberculosis among Chinese Uygurs].
abstract: OBJECTIVE
  To assess the association of copy number variations (CNVs) of exon 11 of IL-23 receptor gene with susceptibility to active pulmonary tuberculosis among Chinese Uygurs.
  
  
  METHODS
  In this study, 250 subjects with active pulmonary tuberculosis (PTB) and 250 normal controls were recruited. A paired case-control study was conducted in the Chinese Uygur population in Xinjiang and the CNV of IL-23R was analyzed using Taqman real-time PCR.
  
  
  RESULTS
  The study showed that the frequencies of different copy number in exon 11 of IL-23R between PTB and control groups were statistically significant (χ(2)=13.35, P<0.01). There were significant difference in CNV of exon 11 in IL-23R between PTB patients and controls (χ(2)=14.95, P<0.01, OR=2.875, 95%CI: 1.655-4.994). The increase of copy number in exon 11 of IL-23R showed significantly different between PTB and control groups (χ(2)=10.475, P=0.0012, OR=2.611, 95%CI: 1.437-4.744).
  
  
  CONCLUSIONS
  The CNV of exon 11 in IL-23R is associated with PTB in the Chinese Uygur population. The increase of the copy number in exon 11 of IL-23R may be a risk factor for PTB in Chinese Uygurs.
authors.affiliation: Department of Pulmonology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China. qimenw@hotmail.com.
authors.forename: Daobin
authors.initials: D
authors.lastname: Jiang
authors.forename: Xin
authors.initials: X
authors.lastname: Hu
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.forename: AbuduJilili
authors.initials: A
authors.lastname: Julaiti
authors.forename: Yu
authors.initials: Y
authors.lastname: Xia
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Wenbao
authors.initials: W
authors.lastname: Zhang
authors.forename: Qimanguli
authors.initials: Q
authors.lastname: Wushouer
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D056915:DNA Copy Number Variations; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018123:Receptors, Interleukin / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin