title: Vasopressin-induced Ca(2+) signals in human adipose-derived stem cells.
abstract: Intracellular Ca(2+) signals are essential for stem cell differentiation due to their ability to control signaling pathways involved in this process. Arginine vasopression (AVP) is a neurohypophyseal hormone that increases intracellular Ca(2+) concentration during adipogenesis via V1a receptors, Gq-proteins and the PLC-IP3 pathway in human adipose-derived stromal/stem cells (hASCs). These Ca(2+) signals originate through calcium release from pools within the endoplasmic reticulum and the extracellular space. AVP supplementation to the adipogenic media inhibits adipogenesis and key adipocyte marker genes. This review focuses on the intersection between AVP, Ca(2+) signals and ASC differentiation.
authors.affiliation: Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address: trantran@iu.edu.
authors.forename: Tran Doan Ngoc
authors.initials: TD
authors.lastname: Tran
authors.affiliation: LaCell LLC, New Orleans Bioinnovation Center, New Orleans, LA 70112, USA; Center for Stem Cell Research & Regenerative Medicine, Tulane University, New Orleans, LA 70112, USA. Electronic address: jgimble@tulane.edu.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Gimble
authors.affiliation: Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address: hcheng@lsu.edu.
authors.forename: Henrique
authors.initials: H
authors.lastname: Cheng
mesh_terms: D050156:Adipogenesis / Q000187:drug effects; D000273:Adipose Tissue / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D001127:Arginine Vasopressin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects*; D006801:Humans; D013234:Stem Cells / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D001127:Arginine Vasopressin; D002118:Calcium
keywords: Arginine vasopressin; Ca(2+) signaling; Differentiation; Human adipose-derived stem cells