title: [THERAPEUTIC ACTIVITY OF MICRONIZED MEBENDAZOLE IN THE MUSCULAR PHASE OF EXPERIMENTAL TRICHINELLA SPIRALIS INVASION IN ALBINO MICE].
abstract: The incidence of trichinosis in Russia was 0.07 per 100,000 population in 2014, which was 2.9-fold higher than that in 2013. Two WHO recommended medications mebendazole and albendazole are now used to treat humari trichinosis. The drugs are active against only mature helminths and non-encysted muscle larvae. The original oil suspension of micronized mebendazole was.found to have 100% efficacy against trichinosis in albino mice in the late muscular phase (encysted larvae) of hyperinvasion after intensive therapy under lifetime diagnostic guidance during and after a treatment cycle. The lifetime diagnostic method used to evaluate the larvicidal activity of anti-trichinosis agents in animals with experimental trichinosis revealed the signs of viaility, established a trend for deatih of Trichinella larvae, and determined their destructive changes.
authors.forename: I V
authors.initials: IV
authors.lastname: Kukhaleva
authors.forename: F P
authors.initials: FP
authors.lastname: Kovalenko
authors.forename: N A
authors.initials: NA
authors.lastname: Shkolyar
authors.forename: Yu A
authors.initials: YA
authors.lastname: Legonkov
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Musaev
authors.forename: T E
authors.initials: TE
authors.lastname: Bulanova
authors.forename: E I
authors.initials: EI
authors.lastname: Samochatova
mesh_terms: D015766:Albendazole / Q000008:administration & dosage; D000818:Animals; D006801:Humans; D007814:Larva / Q000187:drug effects / Q000472:pathogenicity; D008463:Mebendazole / Q000008:administration & dosage*; D051379:Mice; D012426:Russia; D017160:Trichinella spiralis / Q000187:drug effects / Q000472:pathogenicity*; D014235:Trichinellosis / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D008463:Mebendazole; D015766:Albendazole