title: [Characteristics of drug resistance and molecular type of Salmonella typhi and Salmonella paratyphi isolated in Henan province, 2009-2011].
abstract: OBJECTIVE
  To investigate the antibiotic resistance and pulsed field gel electrophoresis (PFGE) patterns of clinical isolates of Salmonella (S.) typhi and S. paratyphi in Henan province during 2009-2011.
  
  
  METHODS
  According to molecular typing and Salmonella K-B drug susceptibility test method published by international PulseNet bacterial infectious disease monitoring network and USA Clinical and Laboratory Standards Institute (CLSI), the drug susceptibility and PFGE molecule characteristics of 78 S. typhi and S. paratyphi strains isolated from sentinel hospitals in Henan were analyzed.
  
  
  RESULTS
  The 78 strains of S. typhi and S. paratyphi were resistant to 13 kinds of antibiotics, in which 62 were multidrug resistant (79.5%), 4 were resistant to 2-3 kinds of antibiotics (5.1%), 41 were resistant to 5-8 kinds of antibiotics (52.6%), 14 were resistant to 9-10 kinds of antibiotics (17.9%), 3 were resistant to 11-12 kinds of antibiotics (3.8%). The resistant rate to cephalosporins, quinolones and other 3 kinds of antibiotic showed an increase trends. Seventy two strains of S. typhi and S. paratyphi could be divided 14 molecular patterns by digestion with XbaⅠ and PFGE, each pattern contains 1-47 strains which shared the similarity of 66.03%-100.00%.
  
  
  CONCLUSIONS
  The drug resistance of clinical isolates of S. typhi and S. paratyphi was serious in Henan. The PFGE patterns showed diversity, but the predominant patterns could be still found. The PFGE patterns of some strains were associated with their drug resistance.
authors.affiliation: Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
authors.forename: Jiayong
authors.initials: J
authors.lastname: Zhao
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Xie
authors.forename: Yujiao
authors.initials: Y
authors.lastname: Mu
authors.forename: Jia
authors.initials: J
authors.lastname: Su
authors.forename: Shengli
authors.initials: S
authors.lastname: Xia
authors.forename: Xueyong
authors.initials: X
authors.lastname: Huang
authors.forename: Bianli
authors.initials: B
authors.lastname: Xu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D002681:China; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D008826:Microbial Sensitivity Tests; D010284:Paratyphoid Fever / Q000382:microbiology; D012482:Salmonella paratyphi A / Q000145:classification / Q000187:drug effects*; D012485:Salmonella typhi / Q000145:classification / Q000187:drug effects*; D018571:Sentinel Surveillance
chemical_list: D000900:Anti-Bacterial Agents