title: Aberrant Circulating Th17 Cells in Patients with B-Cell Non-Hodgkin's Lymphoma.
abstract: Non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of neoplasm in which 90% are B-cell lymphomas and 10% T-cell lymphomas. Although T-helper 17 (Th17) cells have been implicated to be essential in the pathogenesis of autoimmune and inflammatory diseases, its role in B-cell non-Hodgkin's lymphoma (B-NHL) remains unknown. In this study, we observed a significantly decreased frequency of Th17 cells in peripheral blood from B-NHL patients compared with healthy individuals, accompanied with increased Th1 cells. IL-17AF plasma levels were remarkably decreased in B-NHL patients, accompanied with undetectable IL-17FF and unchangeable IL-17AA. Moreover, Th17 and Th1 cells became normalized after one or two cycles of chemotherapy. Interestingly, in B-NHL, circulating Th17 cells frequencies were significantly higher in relapsed patients than those in untreated patients or normal individuals. Meanwhile, there was no statistical difference regarding the frequencies of Th1 cells between relapsed and untreated patients. Taken these data together, circulating Th17 subset immune response may be associated with the response of patients to treatment and with different stages of disease.
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Lu
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, PR China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, PR China.
authors.forename: Congcong
authors.initials: C
authors.lastname: Yin
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, PR China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Ye
authors.affiliation: College of Information Science and Engineering, Shandong University, Jinan, PR China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, PR China.
authors.forename: Daoxin
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, PR China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Ji
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D020381:Interleukin-17 / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D018417:Th1 Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D055815:Young Adult
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17
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