title: Arrhythmias in the Heart Transplant Patient.
abstract: Orthotopic heart transplantation (OHT) is currently the most effective long-term therapy for patients with end-stage cardiac disease, even as left ventricular devices show markedly improved outcomes. As surgical techniques and immunosuppressive regimens have been refined, short-term mortality caused by sepsis has decreased, while morbidity caused by repeated rejection episodes and vasculopathy has increased, and is often manifested by arrhythmias. These chronic transplant complications require early and aggressive multidisciplinary treatment. Understanding the relationship between arrhythmias and these complications in the acute and chronic stages following OHT is critical in improving patient prognosis, as arrhythmias may be the earliest or sole presentation. Finally, decentralised/ denervated hearts represent a unique opportunity to investigate the underlying mechanisms of arrhythmias.
authors.affiliation: UCLA Cardiac Arrhythmia Center, UCLA Health System, David Geffen School of Medicine at UCLA, Los Angeles, US.
authors.forename: David
authors.initials: D
authors.lastname: Hamon
authors.affiliation: Department of Cardiac Electrophysiology, University Clinic of Cardiology, University of St. Cyril and Methodius, Skopje, Former Yugoslav Republic of Macedonia.
authors.forename: Jane
authors.initials: J
authors.lastname: Taleski
authors.affiliation: UCLA Cardiac Arrhythmia Center, UCLA Health System, David Geffen School of Medicine at UCLA, Los Angeles, US.
authors.forename: Marmar
authors.initials: M
authors.lastname: Vaseghi
authors.affiliation: UCLA Cardiac Arrhythmia Center, UCLA Health System, David Geffen School of Medicine at UCLA, Los Angeles, US.
authors.forename: Kalyanam
authors.initials: K
authors.lastname: Shivkumar
authors.affiliation: UCLA Cardiac Arrhythmia Center, UCLA Health System, David Geffen School of Medicine at UCLA, Los Angeles, US.
authors.forename: Noel G
authors.initials: NG
authors.lastname: Boyle
keywords: Orthotopic heart transplantation; arrhythmias; bradyarrhythmia; graft rejection; sudden cardiac death; transplant vasculopathy
references.citation: J Heart Lung Transplant. 2006 Jan;25(1):53-60
references.pmid: 16399531
references.citation: Europace. 2013 Aug;15(8):1070-118
references.pmid: 23801827
references.citation: J Thorac Cardiovasc Surg. 1992 Sep;104(3):812-6
references.pmid: 1513170
references.citation: Cardiovasc Res. 2001 May;50(2):409-16
references.pmid: 11334845
references.citation: J Heart Lung Transplant. 1998 Feb;17 (2):176-84
references.pmid: 9513856
references.citation: J Physiol. 1971 Feb;212(3):685-705
references.pmid: 4933949
references.citation: Heart Rhythm. 2014 Mar;11(3):360-6
references.pmid: 24291775
references.citation: Ann Thorac Surg. 2008 Jan;85(1):56-8
references.pmid: 18154778
references.citation: J Am Heart Assoc. 2012 Apr;1(2):e001461
references.pmid: 23130132
references.citation: Circulation. 1990 Jan;81(1):78-85
references.pmid: 2297851
references.citation: Clin Cardiol. 2005 Nov;28(11 Suppl 1):I3-11
references.pmid: 16450807
references.citation: Circulation. 2008 May 27;117(21):e350-408
references.pmid: 18483207
references.citation: Heart. 2001 Oct;86(4):432-7
references.pmid: 11559685
references.citation: Heart Rhythm. 2010 Nov;7(11):1567-71
references.pmid: 20601151
references.citation: Transplant Proc. 2013 Jan-Feb;45(1):369-75
references.pmid: 23375324
references.citation: Circulation. 2000 Apr 25;101(16):1960-9
references.pmid: 10779463
references.citation: Circulation. 2010 Jun 1;121(21):2255-62
references.pmid: 20479150
references.citation: Nat Neurosci. 2009 Dec;12(12):1494-6
references.pmid: 19881506
references.citation: J Am Coll Cardiol. 1990 Oct;16(4):832-7
references.pmid: 2212366
references.citation: Ann Noninvasive Electrocardiol. 2012 Oct;17 (4):405-8
references.pmid: 23094889
references.citation: Heart Rhythm. 2005 Sep;2(9):931-3
references.pmid: 16171746
references.citation: Ann Intern Med. 2001 Dec 18;135(12):1061-73
references.pmid: 11747385
references.citation: Am J Cardiol. 1996 Jan 1;77(1):47-51
references.pmid: 8540456
references.citation: J Cardiovasc Electrophysiol. 2006 Aug;17(8):827-31
references.pmid: 16903960
references.citation: J Heart Lung Transplant. 1991 Nov-Dec;10(6):931-6
references.pmid: 1756158
references.citation: Am J Cardiol. 1991 Jun 15;67(16):1385-9
references.pmid: 2042569
references.citation: Circulation. 1987 Apr;75(4):696-704
references.pmid: 2881634
references.citation: J Heart Transplant. 1990 Nov-Dec;9(6):587-93
references.pmid: 2277293
references.citation: Europace. 2012 Oct;14(10):1498-505
references.pmid: 22523376
references.citation: Transplant Proc. 1993 Feb;25(1 Pt 2):1172-3
references.pmid: 8442076
references.citation: Heart Rhythm. 2009 Apr;6(4):503-9
references.pmid: 19324311
references.citation: Pacing Clin Electrophysiol. 2013 Jun;36(6):741-7
references.pmid: 23437907
references.citation: Cardiovasc Res. 1989 Nov;23(11):965-72
references.pmid: 2611804
references.citation: Circulation. 1989 Jan;79(1):66-75
references.pmid: 2642757
references.citation: J Am Coll Cardiol. 1995 Jun;25(7):1673-80
references.pmid: 7759722
references.citation: Am J Cardiol. 2010 Sep 1;106(5):737-41
references.pmid: 20723655
references.citation: J Am Coll Cardiol. 2009 Nov 24;54(22):2043-8
references.pmid: 19926011
references.citation: J Cardiovasc Electrophysiol. 2013 May;24(5):498-502
references.pmid: 23387552
references.citation: Am J Physiol. 1987 Oct;253(4 Pt 2):H863-8
references.pmid: 3661734
references.citation: Br Heart J. 1995 Aug;74(2):149-53
references.pmid: 7546993
references.citation: J Heart Lung Transplant. 1991 Sep-Oct;10(5 Pt 1):743-8; discussion 748-9
references.pmid: 1958681
references.citation: J Am Coll Cardiol. 1989 Aug;14(2):338-44
references.pmid: 2666478
references.citation: Circulation. 1990 Mar;81(3):821-8
references.pmid: 2306833
references.citation: Isr Med Assoc J. 2012 Jul;14(7):448-9
references.pmid: 22953623
references.citation: Transplantation. 2003 Jul 15;76(1):137-42
references.pmid: 12865799
references.citation: J Heart Lung Transplant. 1993 Jan-Feb;12(1 Pt 1):133-8; discussion 138-9
references.pmid: 8443190
references.citation: J Am Coll Cardiol. 2008 Jun 10;51(23):2241-9
references.pmid: 18534271
references.citation: Am J Cardiol. 2001 Aug 1;88(3):280-4
references.pmid: 11472708