title: Endocannabinoids in cerebrovascular regulation.
abstract: The cerebral blood flow is tightly regulated by myogenic, endothelial, metabolic, and neural mechanisms under physiological conditions, and a large body of recent evidence indicates that inflammatory pathways have a major influence on the cerebral blood perfusion in certain central nervous system disorders, like hemorrhagic and ischemic stroke, traumatic brain injury, and vascular dementia. All major cell types involved in cerebrovascular control pathways (i.e., smooth muscle, endothelium, neurons, astrocytes, pericytes, microglia, and leukocytes) are capable of synthesizing endocannabinoids and/or express some or several of their target proteins [i.e., the cannabinoid 1 and 2 (CB1 and CB2) receptors and the transient receptor potential vanilloid type 1 ion channel]. Therefore, the endocannabinoid system may importantly modulate the regulation of cerebral circulation under physiological and pathophysiological conditions in a very complex manner. Experimental data accumulated since the late 1990s indicate that the direct effect of cannabinoids on cerebral vessels is vasodilation mediated, at least in part, by CB1 receptors. Cannabinoid-induced cerebrovascular relaxation involves both a direct inhibition of smooth muscle contractility and a release of vasodilator mediator(s) from the endothelium. However, under stress conditions (e.g., in conscious restrained animals or during hypoxia and hypercapnia), cannabinoid receptor activation was shown to induce a reduction of the cerebral blood flow, probably via inhibition of the electrical and/or metabolic activity of neurons. Finally, in certain cerebrovascular pathologies (e.g., subarachnoid hemorrhage, as well as traumatic and ischemic brain injury), activation of CB2 (and probably yet unidentified non-CB1/non-CB2) receptors appear to improve the blood perfusion of the brain via attenuating vascular inflammation.
authors.affiliation: Institute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary; and benyo.zoltan@med.semmelweis-univ.hu.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Benyó
authors.affiliation: Institute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary; and.
authors.forename: Éva
authors.initials: É
authors.lastname: Ruisanchez
authors.affiliation: Institute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary; and.
authors.forename: Miriam
authors.initials: M
authors.lastname: Leszl-Ishiguro
authors.affiliation: Institute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary; and.
authors.forename: Péter
authors.initials: P
authors.lastname: Sándor
authors.affiliation: Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland.
authors.forename: Pál
authors.initials: P
authors.lastname: Pacher
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002560:Cerebrovascular Circulation; D063388:Endocannabinoids / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D010101:Oxygen Consumption; D043882:Receptors, Cannabinoid / Q000378:metabolism; D014664:Vasodilation
chemical_list: D063388:Endocannabinoids; D043882:Receptors, Cannabinoid
keywords: TRPV1 channel; cannabinoid receptors; cerebral circulation; endocannabinoids; neurovascular unit
references.citation: J Neurosci. 2011 Mar 30;31(13):5067-77
references.pmid: 21451044
references.citation: Mol Pharmacol. 1995 Sep;48(3):443-50
references.pmid: 7565624
references.citation: Circ Res. 2004 Nov 12;95(10):e73-81
references.pmid: 15499024
references.citation: J Pharmacol Exp Ther. 1999 Apr;289(1):245-50
references.pmid: 10087011
references.citation: J Neurotrauma. 2011 Jun;28(6):973-81
references.pmid: 21332427
references.citation: Circ Res. 1984 Aug;55(2):197-202
references.pmid: 6744529
references.citation: Psychiatry Res. 2002 Dec 30;116(3):173-85
references.pmid: 12477601
references.citation: Stroke. 2003 May;34(5):1276-80
references.pmid: 12677015
references.citation: Prog Neurobiol. 2011 Nov;95(3):352-72
references.pmid: 21939729
references.citation: J Mol Med (Berl). 2015 Sep;93(9):973-81
references.pmid: 26070437
references.citation: Prostaglandins Other Lipid Mediat. 2000 Apr;61(1-2):71-84
references.pmid: 10785543
references.citation: Physiol Rev. 2003 Jul;83(3):1017-66
references.pmid: 12843414
references.citation: Nature. 2001 Oct 4;413(6855):527-31
references.pmid: 11586361
references.citation: Glia. 2010 Jul;58(9):1017-30
references.pmid: 20468046
references.citation: Pharmacol Ther. 2005 May;106(2):133-45
references.pmid: 15866316
references.citation: Neurosci Lett. 2006 Mar 27;396(2):113-6
references.pmid: 16356641
references.citation: Pharmacol Rev. 2013 Apr;65(2):849-71
references.pmid: 23512546
references.citation: Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2011-22
references.pmid: 11299201
references.citation: Int J Mol Sci. 2014;15(5):8063-74
references.pmid: 24815068
references.citation: Br J Pharmacol. 1999 Jan;126(2):457-66
references.pmid: 10077239
references.citation: Curr Drug Targets. 2015;16(4):334-41
references.pmid: 25469884
references.citation: Br J Pharmacol. 2014 Mar;171(6):1361-78
references.pmid: 24329566
references.citation: Cerebrovasc Brain Metab Rev. 1996 Winter;8(4):326-57
references.pmid: 8969868
references.citation: Lancet. 1972 Nov 25;2(7787):1146
references.pmid: 4117226
references.citation: Br J Pharmacol. 2011 Aug;163(7):1402-10
references.pmid: 21418185
references.citation: Brain Res. 1998 May 18;793(1-2):341-5
references.pmid: 9630717
references.citation: Nat Rev Neurosci. 2004 May;5(5):347-60
references.pmid: 15100718
references.citation: Cerebrovasc Brain Metab Rev. 1990 Summer;2(2):161-92
references.pmid: 2201348
references.citation: Curr Med Chem. 2010;17(14):1393-410
references.pmid: 20166925
references.citation: J Pharmacol Exp Ther. 1997 Jun;281(3):1030-7
references.pmid: 9190833
references.citation: Am J Physiol. 1999 Jun;276(6 Pt 2):H2085-93
references.pmid: 10362691
references.citation: Br J Pharmacol. 1973 Sep;49(1):1-10
references.pmid: 4787563
references.citation: Mol Cell Endocrinol. 2015 Mar 5;403:46-56
references.pmid: 25595485
references.citation: Hypertension. 2008 Oct;52(4):601-7
references.pmid: 18779440
references.citation: Curr Neurovasc Res. 2004 Apr;1(2):129-40
references.pmid: 16185189
references.citation: J Neuroinflammation. 2014;11:191
references.pmid: 25416141
references.citation: Br J Pharmacol. 2012 Mar;165(6):1801-12
references.pmid: 21883148
references.citation: Brain Res Mol Brain Res. 2004 Dec 6;132(1):87-92
references.pmid: 15548432
references.citation: Stroke. 2001 Nov;32(11):2609-14
references.pmid: 11692025
references.citation: Neurochem Int. 1999 Sep;35(3):237-59
references.pmid: 10458655
references.citation: Science. 2011 Nov 11;334(6057):809-13
references.pmid: 22021672
references.citation: Nature. 1993 Sep 2;365(6441):61-5
references.pmid: 7689702
references.citation: Am J Physiol. 1995 Dec;269(6 Pt 2):H1859-64
references.pmid: 8594893
references.citation: Eur J Pharmacol. 1998 Nov 27;362(1):R1-3
references.pmid: 9865537
references.citation: J Pharmacol Exp Ther. 1983 Nov;227(2):508-16
references.pmid: 6313906
references.citation: Brain Res. 1993 May 7;610(2):248-55
references.pmid: 8319087
references.citation: Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3216-28
references.pmid: 23108541
references.citation: Mol Pain. 2009;5:25
references.pmid: 19476641
references.citation: Cell Signal. 1999 Mar;11(3):189-93
references.pmid: 10353693
references.citation: Neuroreport. 2008 Oct 29;19(16):1601-4
references.pmid: 18815586
references.citation: Acta Neurochir Suppl. 2011;110(Pt 1):191-6
references.pmid: 21116938
references.citation: J Cereb Blood Flow Metab. 1998 Jun;18(6):616-8
references.pmid: 9626185
references.citation: PLoS One. 2012;7(5):e37798
references.pmid: 22662226
references.citation: Circ J. 2010 Apr;74(4):608-16
references.pmid: 20234102
references.citation: J Chem Neuroanat. 2014 Sep;59-60:62-71
references.pmid: 24978314
references.citation: Mol Endocrinol. 2011 Nov;25(11):1835-48
references.pmid: 21964594
references.citation: Br J Pharmacol. 2010 Jun;160(3):688-700
references.pmid: 20590572
references.citation: Neurobiol Dis. 2006 May;22(2):257-64
references.pmid: 16364651
references.citation: Neuroscience. 2006;139(4):1405-15
references.pmid: 16603318
references.citation: Brain Pathol. 2011 Sep;21(5):544-57
references.pmid: 21251115
references.citation: Stroke. 2011 Nov;42(11):3323-8
references.pmid: 21940972
references.citation: Nature. 2006 Oct 12;443(7112):700-4
references.pmid: 17036005
references.citation: Glia. 2009 Feb;57(3):286-94
references.pmid: 18837048
references.citation: Glia. 2003 Jan 15;41(2):161-8
references.pmid: 12509806
references.citation: Am J Pathol. 2013 Nov;183(5):1548-58
references.pmid: 24055259
references.citation: Mol Pharmacol. 1988 Nov;34(5):605-13
references.pmid: 2848184
references.citation: Circ Res. 1979 Sep;45(3):331-8
references.pmid: 455598
references.citation: J Clin Invest. 1948 Jul;27(4):484-92
references.pmid: 16695569
references.citation: PLoS One. 2013;8(1):e53390
references.pmid: 23308211
references.citation: Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1352-63
references.pmid: 19304946
references.citation: Semin Immunopathol. 2009 Jun;31(1):63-77
references.pmid: 19357846
references.citation: Neuropsychopharmacology. 1998 Dec;19(6):481-91
references.pmid: 9803424
references.citation: J Biol Chem. 2000 May 5;275(18):13484-92
references.pmid: 10788462
references.citation: Pediatr Res. 1986 Feb;20(2):131-5
references.pmid: 3945523
references.citation: Eur J Pharmacol. 2001 Jul 6;423(2-3):203-10
references.pmid: 11448486
references.citation: Eur J Biochem. 2001 Apr;268(7):1982-9
references.pmid: 11277920
references.citation: J Physiol. 1984 Feb;347:35-45
references.pmid: 6423816
references.citation: J Appl Physiol (1985). 2006 Mar;100(3):1059-64
references.pmid: 16467392
references.citation: Br J Pharmacol. 1990 Jun;100(2):312-8
references.pmid: 2379036
references.citation: Glia. 2000 Jan 1;29(1):58-69
references.pmid: 10594923
references.citation: Neuroreport. 1993 Mar;4(3):267-70
references.pmid: 8477049
references.citation: Br J Pharmacol. 1996 Sep;119(1):107-14
references.pmid: 8872363
references.citation: J Neurosci. 2002 Nov 15;22(22):9771-5
references.pmid: 12427832
references.citation: Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):162-8
references.pmid: 15857679
references.citation: Nat Med. 2001 Jul;7(7):827-32
references.pmid: 11433348
references.citation: Res Commun Chem Pathol Pharmacol. 1972 May;3(3):483-92
references.pmid: 5034510
references.citation: Handb Exp Pharmacol. 2005;(168):299-325
references.pmid: 16596779
references.citation: J Physiol. 1890 Jan;11(1-2):85-158.17
references.pmid: 16991945
references.citation: Synapse. 2004 Sep 15;53(4):208-13
references.pmid: 15266552
references.citation: Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H299-308
references.pmid: 24322615
references.citation: J Neurol Sci. 2014 Jul 15;342(1-2):101-6
references.pmid: 24819918
references.citation: Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1075-85
references.pmid: 22198176
references.citation: J Pharmacol Exp Ther. 1999 Mar;288(3):1357-66
references.pmid: 10027878
references.citation: Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H373-81
references.pmid: 21602473
references.citation: Am J Physiol. 1994 Jul;267(1 Pt 2):H296-301
references.pmid: 8048594
references.citation: Circ Res. 2000 Aug 18;87(4):323-7
references.pmid: 10948067
references.citation: Br J Pharmacol. 1996 Aug;118(8):2023-8
references.pmid: 8864538
references.citation: Br J Pharmacol. 2004 Jul;142(6):943-52
references.pmid: 15226190
references.citation: Toxicol Appl Pharmacol. 1974 Apr;28(1):18-27
references.pmid: 4852457
references.citation: Cell. 2013 Nov 21;155(5):1154-65
references.pmid: 24267894
references.citation: Am J Physiol. 1990 Oct;259(4 Pt 2):H1171-7
references.pmid: 2121049
references.citation: Eur J Pharmacol. 1997 Sep 24;335(2-3):205-9
references.pmid: 9369375
references.citation: Invest Ophthalmol Vis Sci. 1994 Mar;35(3):991-7
references.pmid: 7907321
references.citation: Transl Stroke Res. 2014 Apr;5(2):269-77
references.pmid: 24323710
references.citation: J Neuroimmune Pharmacol. 2015 Jun;10(2):302-8
references.pmid: 25666933
references.citation: Physiol Rev. 1998 Jan;78(1):53-97
references.pmid: 9457169
references.citation: J Physiol. 1902 May 28;28(3):220-31
references.pmid: 16992618
references.citation: J Am Coll Cardiol. 2001 Dec;38(7):2048-54
references.pmid: 11738314
references.citation: Circ Res. 1987 Jan;60(1):102-7
references.pmid: 3568282
references.citation: Vitam Horm. 2009;81:389-419
references.pmid: 19647120
references.citation: Circ Res. 1964 Aug;15:SUPPL:279-87
references.pmid: 14206315
references.citation: J Cardiovasc Pharmacol. 1985;7 Suppl 3:S36-46
references.pmid: 2409398
references.citation: J Physiol. 1992 Apr;449:183-96
references.pmid: 1522509
references.citation: Biochem Biophys Res Commun. 1996 Dec 4;229(1):114-20
references.pmid: 8954092
references.citation: Brain Behav Immun. 2012 Nov;26(8):1191-201
references.pmid: 22728326
references.citation: J Cereb Blood Flow Metab. 1989 Dec;9(6):786-94
references.pmid: 2684992
references.citation: J Vasc Res. 2012;49(5):375-89
references.pmid: 22739136
references.citation: Front Neurosci. 2014 May 09;8:103
references.pmid: 24847203
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3214-9
references.pmid: 14976257
references.citation: Biochem J. 2000 Mar 15;346 Pt 3:835-40
references.pmid: 10698714
references.citation: J Neurol Neurosurg Psychiatry. 2001 Apr;70(4):534-7
references.pmid: 11254783
references.citation: J Neurosci. 2003 Feb 15;23(4):1398-405
references.pmid: 12598628
references.citation: Circ Res. 1983 May;52(5):527-33
references.pmid: 6851007
references.citation: Biochem Pharmacol. 1994 Sep 15;48(6):1253-64
references.pmid: 7945419
references.citation: Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):301-8
references.pmid: 13680088
references.citation: J Pharm Pharmacol. 2011 May;63(5):636-47
references.pmid: 21492165
references.citation: Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):105-11
references.pmid: 19615459
references.citation: Am J Physiol. 1987 Mar;252(3 Pt 2):H671-3
references.pmid: 3103472
references.citation: Clin Neurophysiol. 2008 Apr;119(4):731-43
references.pmid: 18187361
references.citation: Life Sci. 2007 Apr 17;80(19):1738-45
references.pmid: 17379256
references.citation: Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H533-41
references.pmid: 15821037
references.citation: Science. 2005 Oct 14;310(5746):329-32
references.pmid: 16224028
references.citation: Neurobiol Dis. 2006 Oct;24(1):15-27
references.pmid: 16762556
references.citation: Neurochem Int. 2012 Jul;61(2):166-74
references.pmid: 22579570
references.citation: Nat Med. 2009 Sep;15(9):1031-7
references.pmid: 19718040
references.citation: Trends Pharmacol Sci. 2006 Jan;27(1):1-4
references.pmid: 16318877
references.citation: Arch Neurol. 1972 Jul;27(1):1-6
references.pmid: 4626103
references.citation: J Cereb Blood Flow Metab. 2005 Apr;25(4):477-84
references.pmid: 15729296
references.citation: J Cardiovasc Pharmacol. 2004 Nov;44(5):517-9
references.pmid: 15505486
references.citation: Anesthesiology. 2003 Dec;99(6):1333-9
references.pmid: 14639145
references.citation: Pharmacol Rev. 2010 Dec;62(4):588-631
references.pmid: 21079038
references.citation: BMC Neurosci. 2010;11:44
references.pmid: 20346144
references.citation: Br J Pharmacol. 2008 Jan;153(2):252-62
references.pmid: 18026124
references.citation: Curr Vasc Pharmacol. 2009 Jan;7(1):15-25
references.pmid: 19149636
references.citation: Stroke. 2015 Aug;46(8):2260-70
references.pmid: 26138121
references.citation: J Mol Signal. 2012 Jul 26;7(1):10
references.pmid: 22834922
references.citation: J Cereb Blood Flow Metab. 2003 Sep;23(9):1085-95
references.pmid: 12973025
references.citation: Stroke. 2001 Jun;32(6):1394-400
references.pmid: 11387504
references.citation: Circ Res. 1984 Oct;55(4):554-9
references.pmid: 6478557
references.citation: Pharmacol Ther. 2002 Aug;95(2):191-202
references.pmid: 12182966
references.citation: Gastroenterology. 2013 Apr;144(4):808-817.e15
references.pmid: 23295443
references.citation: Brain Res Brain Res Rev. 1995 Mar;20(3):269-87
references.pmid: 7550361
references.citation: Crit Rev Neurobiol. 2004;16(4):237-70
references.pmid: 15862108
references.citation: Br J Pharmacol. 1999 Apr;126(7):1593-600
references.pmid: 10323591
references.citation: Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2210-8
references.pmid: 17660390
references.citation: Nat Med. 2008 Jan;14(1):64-8
references.pmid: 18084302
references.citation: Eur J Pharmacol. 2007 Mar 22;559(2-3):189-95
references.pmid: 17292352
references.citation: Pharmacol Rev. 2013;65(4):1135-47
references.pmid: 23893067
references.citation: J Auton Nerv Syst. 1994 Sep;49 Suppl:S73-6
references.pmid: 7530735
references.citation: Kidney Int Suppl. 1998 Sep;67:S224-5
references.pmid: 9736298
references.citation: Acta Psychiatr Scand. 1999 Jul;100(1):67-75
references.pmid: 10442442
references.citation: Life Sci. 1976 Jul 1;19(1):99-104
references.pmid: 940439
references.citation: Am J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H609-19
references.pmid: 23792684
references.citation: J Appl Physiol (1985). 2006 Jan;100(1):307-17
references.pmid: 16357084
references.citation: Nature. 1997 Aug 21;388(6644):773-8
references.pmid: 9285589
references.citation: Trends Pharmacol Sci. 2015 May;36(5):277-96
references.pmid: 25796370
references.citation: Br J Pharmacol. 2006 Aug;148(7):1022-32
references.pmid: 16770320
references.citation: Brain Res. 1994 Dec 26;667(2):255-62
references.pmid: 7697363
references.citation: Nature. 1997 Dec 4;390(6659):518-21
references.pmid: 9394002
references.citation: FASEB J. 2007 Jun;21(8):1788-800
references.pmid: 17327359
references.citation: Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H622-32
references.pmid: 18055520
references.citation: Nature. 1994 Dec 15;372(6507):686-91
references.pmid: 7990962
references.citation: Exp Neurol. 2014 Nov;261:396-403
references.pmid: 25058046
references.citation: Life Sci. 2005 Feb 4;76(12):1307-24
references.pmid: 15670612
references.citation: Cardiovasc Eng. 2008 Mar;8(1):42-59
references.pmid: 18041584
references.citation: J Cereb Blood Flow Metab. 2011 Oct;31(10):2096-105
references.pmid: 21610722
references.citation: FASEB J. 1998 Aug;12(11):1035-44
references.pmid: 9707176
references.citation: Cardiovasc Res. 2010 Mar 1;85(4):773-84
references.pmid: 19942623
references.citation: Neurochem Int. 2012 Jan;60(1):1-8
references.pmid: 22085448
references.citation: Life Sci. 1987 Jul 6;41(1):79-87
references.pmid: 3037218
references.citation: J Physiol. 2004 Jul 15;558(Pt 2):647-57
references.pmid: 15121805
references.citation: J Mol Endocrinol. 2010 Feb;44(2):75-85
references.pmid: 19620237
references.citation: Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H397-404
references.pmid: 24878770
references.citation: J Neurosci Res. 2009 Jan;87(1):1-11
references.pmid: 18709660
references.citation: J Pharmacol Exp Ther. 2007 Jun;321(3):930-7
references.pmid: 17379772
references.citation: Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H311-7
references.pmid: 23144316
references.citation: Acta Physiol (Oxf). 2011 Sep;203(1):47-59
references.pmid: 21272266
references.citation: Br J Pharmacol. 2003 Sep;140(2):384-94
references.pmid: 12970095
references.citation: Trends Pharmacol Sci. 2012 Jun;33(6):331-40
references.pmid: 22503477
references.citation: Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8756-61
references.pmid: 15138300
references.citation: Am J Physiol. 1987 Jul;253(1 Pt 2):H165-75
references.pmid: 3037925
references.citation: Mol Pharmacol. 2008 May;73(5):1405-12
references.pmid: 18256211
references.citation: J Cereb Blood Flow Metab. 1994 Mar;14(2):175-92
references.pmid: 7509338
references.citation: Front Behav Neurosci. 2012 Mar 14;6:9
references.pmid: 22457644
references.citation: Biochem Biophys Res Commun. 1998 Feb 24;243(3):838-43
references.pmid: 9501013
references.citation: FEBS Lett. 2009 Jun 18;583(12):2071-6
references.pmid: 19464294
references.citation: Transl Stroke Res. 2013 Aug;4(4):432-46
references.pmid: 23894255
references.citation: J Physiol. 1997 Jan 15;498 ( Pt 2):371-9
references.pmid: 9032685
references.citation: Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2046-54
references.pmid: 12003810
references.citation: Am J Physiol. 1999 Apr;276(4 Pt 2):H1253-62
references.pmid: 10199850
references.citation: J Immunol. 2008 Nov 1;181(9):6406-16
references.pmid: 18941231
references.citation: Diabetes. 2012 Mar;61(3):716-27
references.pmid: 22315315
references.citation: Br J Pharmacol. 2012 Apr;165(8):2462-78
references.pmid: 21449982
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22290-5
references.pmid: 21135230
references.citation: Pharmacol Biochem Behav. 1997 Aug;57(4):625-31
references.pmid: 9258987
references.citation: Prog Lipid Res. 2011 Apr;50(2):193-211
references.pmid: 21295074
references.citation: Naunyn Schmiedebergs Arch Pharmacol. 2000 May;361(5):535-42
references.pmid: 10832608
references.citation: Acta Physiol Scand. 1992 Jul;145(3):297-8
references.pmid: 1519487
references.citation: J Neurosci. 2004 Sep 15;24(37):8068-74
references.pmid: 15371507
references.citation: Arch Biochem Biophys. 2001 Sep 15;393(2):321-8
references.pmid: 11556820
references.citation: World Neurosurg. 2010 Jan;73(1):22-41
references.pmid: 20452866
references.citation: Neuroscientist. 2009 Dec;15(6):579-88
references.pmid: 19359669
references.citation: Nature. 1990 Aug 9;346(6284):561-4
references.pmid: 2165569
references.citation: Acta Neurochir (Wien). 2003 Jul;145(7):579-82
references.pmid: 12910401
references.citation: J Biol Chem. 2002 Jun 7;277(23):20869-76
references.pmid: 11916961
references.citation: Science. 1992 Dec 18;258(5090):1946-9
references.pmid: 1470919
references.citation: Prog Neurobiol. 2011 Nov;95(3):406-26
references.pmid: 21963551
references.citation: Stroke. 2009 Mar;40(3 Suppl):S13-5
references.pmid: 19064799
references.citation: Methods Enzymol. 2010;484:3-30
references.pmid: 21036224
references.citation: Lancet Neurol. 2009 Feb;8(2):175-91
references.pmid: 19161909
references.citation: J Cereb Blood Flow Metab. 2015 Jun;35(6):883-7
references.pmid: 25853910
references.citation: J Neurosci Res. 2012 Dec;90(12):2293-305
references.pmid: 22903455
references.citation: J Biol Chem. 2012 Sep 7;287(37):31540-50
references.pmid: 22787147
references.citation: Trends Mol Med. 2002 Feb;8(2):58-61
references.pmid: 11815270
references.citation: Eur J Pharmacol. 1987 Jan 28;134(1):15-24
references.pmid: 3556398
references.citation: Br J Surg. 1972 Nov;59(11):897
references.pmid: 4629180
references.citation: Biochim Biophys Acta. 2015 Apr;1851(4):366-76
references.pmid: 25543004
references.citation: J Cereb Blood Flow Metab. 2008 Jan;28(1):111-25
references.pmid: 17519974
references.citation: Neurosurgery. 1998 Apr;42(4):834-41; discussion 841-2
references.pmid: 9574648
references.citation: Eur J Pharmacol. 1995 May 24;278(3):279-83
references.pmid: 7589169
references.citation: Am J Physiol Heart Circ Physiol. 2013 Jun 15;304(12):H1598-614
references.pmid: 23585139
references.citation: Proc Soc Exp Biol Med. 2000 Oct;225(1):1-8
references.pmid: 10998193
references.citation: FEBS Lett. 1999 Oct 8;459(2):277-81
references.pmid: 10518035
references.citation: Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1751-61
references.pmid: 11247789
references.citation: Biochem J. 1997 Mar 1;322 ( Pt 2):671-7
references.pmid: 9065792
references.citation: Hypertension. 1997 May;29(5):1204-10
references.pmid: 9149688
references.citation: Biochem Pharmacol. 1996 Mar 8;51(5):669-76
references.pmid: 8615904
references.citation: Prog Neurobiol. 2008 Dec 11;86(4):379-95
references.pmid: 18835324
references.citation: Mol Pharmacol. 1992 Nov;42(5):838-45
references.pmid: 1331766
references.citation: Circulation. 2004 Oct 5;110(14):1996-2002
references.pmid: 15451779
references.citation: Mol Neurobiol. 2012 Apr;45(2):327-47
references.pmid: 22371274
references.citation: Prostaglandins Other Lipid Mediat. 2004 Jan;73(1-2):59-72
references.pmid: 15165032
references.citation: Neuromolecular Med. 2014 Sep;16(3):620-42
references.pmid: 24929655
references.citation: Proc Soc Exp Biol Med. 1971 Jan;136(1):260-3
references.pmid: 5540621
references.citation: J Appl Physiol. 1967 Aug;23(2):183-9
references.pmid: 6031186
references.citation: Am J Physiol. 1991 May;260(5 Pt 2):H1575-80
references.pmid: 2035677
references.citation: Nature. 1999 Jul 29;400(6743):452-7
references.pmid: 10440374
references.citation: J Cereb Blood Flow Metab. 1994 Jan;14(1):49-58
references.pmid: 7505282
references.citation: Regul Pept. 2008 Oct 9;150(1-3):66-72
references.pmid: 18584893
references.citation: Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14136-41
references.pmid: 10570211
references.citation: Int J Microcirc Clin Exp. 1996 Nov-Dec;16(6):277-83
references.pmid: 9049705
references.citation: Circ Res. 1966 Nov;19(5):903-10
references.pmid: 5954123
references.citation: Br J Pharmacol. 2004 May;142(1):20-6
references.pmid: 15131000
references.citation: J Pharmacol Exp Ther. 1998 Aug;286(2):697-703
references.pmid: 9694923
references.citation: Neuroreport. 2009 Jul 15;20(11):1027-31
references.pmid: 19579269
references.citation: J Cereb Blood Flow Metab. 1992 Sep;12(5):750-8
references.pmid: 1324250
references.citation: Glia. 2003 Oct;44(1):85-90
references.pmid: 12951660
references.citation: Hypertension. 2009 Jul;54(1):150-6
references.pmid: 19470883
references.citation: Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H1-14
references.pmid: 24163077
references.citation: Circulation. 2000 Nov 7;102(19):2434-40
references.pmid: 11067800