title: [THE INFLUENCE OF CARBON MONOXIDE ON THE PARAMETERS OF PROOXIDANT-ANTIOXIDANT BALANCE DURING HEPATIC ISCHEMIA-REPERFUSION SYNDROME IN RATS].
abstract: The influence of carbon monoxide on the blood and liver prooxidant-antioxidant parameters: lipid peroxidation products (conjugated dienes, malondialdehyde, Schiff bases) and antioxidant system parameters (catalase, retinol, α-tocopherol, glutathione) were investigated in rats during hepatic ischemia-reperfusion. Hepatic ischemia was induced by Pringle maneuver for 30 min, reperfusion period was 120 min. It is detected, that hepatic ischemia-reperfusion leads to intensification of lipid peroxidation with declining of antioxidant defense. Infusion of the donor CO before reperfusion period improves the prooxidant-antioxidant balance in the blood and liver. In conclusion, CO increases the antioxidant activity of the blood and liver, decreases lipid peroxidation processes, that's correct oxidative damages during hepatic ischemia-reperfusion.
authors.forename: M N
authors.initials: MN
authors.lastname: Khodosovsky
authors.forename: V V
authors.initials: VV
authors.lastname: Zinchuk
authors.forename: I E
authors.initials: IE
authors.lastname: Gulyai
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009942:Organometallic Compounds / Q000378:metabolism / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D012545:Schiff Bases / Q000378:metabolism; D014801:Vitamin A / Q000378:metabolism; D024502:alpha-Tocopherol / Q000378:metabolism
chemical_list: D009942:Organometallic Compounds; D020011:Protective Agents; D012545:Schiff Bases; C476530:tricarbonylchloro(glycinato)ruthenium(II); D014801:Vitamin A; D008315:Malondialdehyde; D002248:Carbon Monoxide; D002374:Catalase; D005978:Glutathione; D024502:alpha-Tocopherol