title: Quantitative Assessment of Vectorcardiographic Loop Morphology.
abstract: Vectorcardiography (VCG), developed 100years ago, characterizes clinically important electrophysiological properties of the heart. In this study, VCG QRS loop roundness, planarity, thickness, rotational angle, and dihedral angle were measured in 81 healthy control subjects (39.0±14.2y; 51.8% male; 94% white), and 8 patients with infarct-cardiomyopathy and sustained monomorphic ventricular tachycardia (VT) (68.0±7.8y, 37.5% male). The angle between two consecutive QRS vectors was defined as the rotational angle, while dihedral angle quantified planar alteration over the QRS loop. In VT subjects, planarity index decreased (0.63±0.22 vs. 0.88±0.10; P=0.014), and dihedral angle was significantly more variable (variance of dihedral angle, median (IQR): 897(575-1450) vs. 542(343-773); P=0.029; rMSSD: 47.7±12.7 vs. 35.1±13.1; P=0.027). Abnormal electrophysiological substrate in VT patients is characterized by the appearance of QRS loop folding, likely due to local conduction block. The presence of fragmented QRS complexes on the 12-lead ECG had low sensitivity (31%) for detecting QRS loop folding on the VCG.
authors.affiliation: Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR; Portland State University, Portland, OR.
authors.forename: Golriz
authors.initials: G
authors.lastname: Sedaghat
authors.affiliation: Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR; University of Utah, Salt Lake City, UT.
authors.forename: Elyar
authors.initials: E
authors.lastname: Ghafoori
authors.affiliation: Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Waks
authors.affiliation: Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR.
authors.forename: Muammar M
authors.initials: MM
authors.lastname: Kabir
authors.affiliation: Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
authors.forename: Alexei
authors.initials: A
authors.lastname: Shvilkin
authors.affiliation: Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Josephson
authors.affiliation: Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR. Electronic address: tereshch@ohsu.edu.
authors.forename: Larisa G
authors.initials: LG
authors.lastname: Tereshchenko
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D015233:Models, Statistical; D009203:Myocardial Infarction / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017180:Tachycardia, Ventricular / Q000175:diagnosis*; D014672:Vectorcardiography / Q000379:methods*
keywords: Planarity; Vectorcardiography; Ventricular tachycardia
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