title: Preferential interaction of the Alzheimer peptide Aβ-(1-42) with Omega-3-containing lipid bilayers: structure and interaction studies.
abstract: Many age-related neurodegenerative diseases, including Alzheimer Disease (AD), are elicited by an interplay of genetic, environmental, and dietary factors. Food rich in Omega-3 phospholipids seems to reduce the AD incidence. To investigate the molecular basis of this beneficial effect, we have investigated by CD and ESR studies the interaction between the Alzheimer peptide Aβ-(1-42) and biomimetic lipid bilayers. The inclusion of 1,2-didocosahexaenoyl-sn-glycero-3-phosphocholine does not change significantly the bilayers organization, but favors its Aβ-(1-42) interaction. The Omega-3 lipid amount modulates the effect intensity, suggesting a peptide selectivity for membranes containing polyunsatured fatty acids (PUFA) and providing hints for the mechanism and therapy of AD.
authors.affiliation: Department of Chemical Sciences, University of Naples Federico II, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Emendato
authors.affiliation: Department of Chemical Sciences, University of Naples Federico II, Italy.|Department of Science and Technologies, University of Sannio, Benevento, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Spadaccini
authors.affiliation: Department of Chemical Sciences, University of Naples Federico II, Italy.|CSGI, Consorzio interuniversitario per lo sviluppo dei Sistemi a Grande Interfase, Unit of Naples, Italy.
authors.forename: Augusta
authors.initials: A
authors.lastname: De Santis
authors.affiliation: Department of Chemical and Pharmaceutical Sciences and Laboratorio per le tecnologie delle terapie avanzate (LTTA), University of Ferrara, Italy.
authors.forename: Remo
authors.initials: R
authors.lastname: Guerrini
authors.affiliation: Department of Chemical Sciences, University of Naples Federico II, Italy.|CSGI, Consorzio interuniversitario per lo sviluppo dei Sistemi a Grande Interfase, Unit of Naples, Italy.
authors.forename: Gerardino
authors.initials: G
authors.lastname: D'Errico
authors.affiliation: Department of Chemical Sciences, University of Naples Federico II, Italy.
authors.forename: Delia
authors.initials: D
authors.lastname: Picone
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry; D002942:Circular Dichroism; D004281:Docosahexaenoic Acids / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D015525:Fatty Acids, Omega-3 / Q000737:chemistry*; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry*; D011487:Protein Conformation; D012995:Solubility
chemical_list: D016229:Amyloid beta-Peptides; D015525:Fatty Acids, Omega-3; D008051:Lipid Bilayers; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D004281:Docosahexaenoic Acids
keywords: Abeta toxic oligomers; Alzheimer disease; Omega-3 lipids; amyloid β-peptide (1-42); biomimetic lipid bilayers; peptide-membrane interactions