title: Does the addition of a second daily session of hyperbaric oxygen therapy to intratympanic steroid influence the outcomes of sudden hearing loss?
abstract: The aim of this study is to investigate whether, in addition to intratympanic steroid therapy, additional hyperbaric oxygen therapy (HBOT) sessions per day (twice a day for 5 days) is more useful than one session per day for 10 days in patients affected by severe and profound idiopathic sudden sensorineural hearing loss (ISSNHL). A total of 55 patients affected by unilateral severe and profound ISSNHL were recruited. Two protocols were adopted. In the first, 27 patients (13 with profound and 14 with severe hearing loss) underwent one session of HBOT per day for 10 days, 6 days a week. An HBOT session comprised a period of 14 minutes air compression followed by 90 min at 2.4 atm absolute (ATA) followed by a decompression period of 15 min in oxygen. Patients breathed 100% oxygen through an appropriate mask checked for leaks. Patients were given 0.4 ml of 62.5 mg/ml of intratympanic prednisolone during the first three days of the protocol. In the second protocol, 28 patients (10 with profound and 18 with severe hearing loss) received 10 sessions of HBOT, twice a day for five days, 2.4 ATA 90 min 100% oxygen. The intratympanic injections of prednisolone were given between the two sessions of HBOT during the first three days of the protocol. Since there were no significant differences in hearing outcomes between the two protocols, the present study shows that the protocol of two sessions of HBOT per day is a valid treatment and equally effective as the one HBOT session per day, but with shorter treatment time.
authors.affiliation: Department of Sensory Organs, Sapienza Università di Roma, Rome, Italy;
authors.forename: G
authors.initials: G
authors.lastname: Attanasio
authors.affiliation: Department of Sensory Organs, Sapienza Università di Roma, Rome, Italy;
authors.forename: E
authors.initials: E
authors.lastname: Covelli
authors.affiliation: Department of Sensory Organs, Sapienza Università di Roma, Rome, Italy;
authors.forename: L
authors.initials: L
authors.lastname: Cagnoni
authors.affiliation: Department of Sensory Organs, Sapienza Università di Roma, Rome, Italy;
authors.forename: E
authors.initials: E
authors.lastname: Masci
authors.affiliation: Department of Sensory Organs, Sapienza Università di Roma, Rome, Italy;
authors.forename: D
authors.initials: D
authors.lastname: Ferraro
authors.affiliation: Department of Sensory Organs, Sapienza Università di Roma, Rome, Italy;
authors.forename: P
authors.initials: P
authors.lastname: Mancini
authors.affiliation: Department of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences, "Umberto I" Hospital, Sapienza Università di Rome, Italy;
authors.forename: E
authors.initials: E
authors.lastname: Alessandri
authors.affiliation: Department of Sensory Organs, Sapienza Università di Roma, Rome, Italy;
authors.forename: G
authors.initials: G
authors.lastname: Cartocci
authors.affiliation: Department of Sensory Organs, Sapienza Università di Roma, Rome, Italy;
authors.forename: R
authors.initials: R
authors.lastname: Filipo
authors.affiliation: Pain Unit, Department of Medical-Surgical, Techno-Biomedical Sciences and Translational Medicine, Sapienza Università di Roma, "Sant'Andrea Hospital", Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rocco
mesh_terms: D001301:Audiometry, Pure-Tone; D006319:Hearing Loss, Sensorineural / Q000628:therapy*; D003639:Hearing Loss, Sudden / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D013256:Steroids
keywords: Cochlea; Deafness; Hypoxia; Inner ear; Prednisolone; Pure-tone average
references.citation: Otol Neurotol. 2003 Sep;24(5):728-33
references.pmid: 14501447
references.citation: Clin Otolaryngol Allied Sci. 2002 Dec;27(6):458-63
references.pmid: 12472512
references.citation: J Trauma. 1984 Aug;24(8):742-6
references.pmid: 6471139
references.citation: Rev Laryngol Otol Rhinol (Bord). 1987;108(4):339-41
references.pmid: 3432783
references.citation: Wien Klin Wochenschr. 1995;107(23):739-41
references.pmid: 8560898
references.citation: Otolaryngol Head Neck Surg. 2007 Jul;137(1):74-8
references.pmid: 17599569
references.citation: Laryngoscope. 2009 Feb;119(2):359-69
references.pmid: 19172627
references.citation: Lancet. 2010 Apr 3;375(9721):1203-11
references.pmid: 20362815
references.citation: Acta Otolaryngol. 2010 Nov;130(11):1209-13
references.pmid: 20735183
references.citation: Wound Repair Regen. 2011 Mar-Apr;19(2):149-61
references.pmid: 21362081
references.citation: Acta Otorhinolaryngol Ital. 2011 Apr;31(2):85-9
references.pmid: 22058587
references.citation: Acta Otorhinolaryngol Ital. 2011 Dec;31(6):395-8
references.pmid: 22323851
references.citation: Otolaryngol Head Neck Surg. 2012 Mar;146(3 Suppl):S1-35
references.pmid: 22383545
references.citation: Acta Otolaryngol. 2012 May;132(5):475-81
references.pmid: 22292673
references.citation: Am J Otolaryngol. 2013 Nov-Dec;34(6):759-61
references.pmid: 23937973
references.citation: Audiol Neurootol. 2014;19(4):225-33
references.pmid: 24992949
references.citation: Aviat Space Environ Med. 2000 Feb;71(2):119-24
references.pmid: 10685584
references.citation: Otolaryngol Head Neck Surg. 2002 Feb;126(2):121-6
references.pmid: 11870340
references.citation: Acta Otolaryngol. 1979;88(5-6):335-42
references.pmid: 532608