title: Antiviral and Cytotoxic Isocoumarin Derivatives from an Endophytic Fungus Aspergillus oryzae.
abstract: Oryzaeins A-D (1-4), four new isocoumarin derivatives, along with five known ones (5-9) were isolated from solid cultures of an endophytic fungus Aspergillus oryzae. Their structures were elucidated by detailed spectroscopic analysis and by comparison with reported data of related derivatives. Among them, compounds 1 and 2 represent the first examples of isocoumarins possessing an unusual 2-oxopropyl group and a rare 3-hydroxypropyl group. Compounds 1 and 2 displayed moderate anti-tobacco mosaic virus activities with inhibition rates of 28.4% and 30.6%, respectively, at the concentration of 20 µM. The new compounds showed moderate inhibitory activities against several human tumor cell lines with IC50 values in the range of 2.8-8.8 µM. Supporting information available online at http://www.thieme-connect.de/products.
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhou
authors.affiliation: Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming, P. R. China.
authors.forename: Pei
authors.initials: P
authors.lastname: He
authors.affiliation: Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming, P. R. China.
authors.forename: Kun-Miao
authors.initials: KM
authors.lastname: Wang
authors.affiliation: Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming, P. R. China.
authors.forename: Rui-Zhi
authors.initials: RZ
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China.
authors.forename: Yue-De
authors.initials: YD
authors.lastname: Wang
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China.
authors.forename: Gan-Peng
authors.initials: GP
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Yang
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China.
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Ye
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Du
authors.affiliation: Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming, P. R. China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China.
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Hu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001236:Aspergillus oryzae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002681:China; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D049934:Isocoumarins / Q000494:pharmacology*; D015394:Molecular Structure; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D049934:Isocoumarins