title: Influence of Shorter Duration of Prophylactic Antibiotic Use on the Incidence of Surgical Site Infection Following Colorectal Cancer Surgery.
abstract: OBJECTIVE
  This study aimed to identify the risk factors for surgical site infections (SSIs) in patients undergoing colorectal cancer surgery and to determine whether significantly different SSI rates existed between the short prophylactic antibiotic use group (within 24 hours) and the long prophylactic antibiotic use group (beyond 24 hours).
  
  
  METHODS
  The medical records of 327 patients who underwent colorectal resection due to colorectal cancer from January 2010 to May 2014 at a single center were retrospectively reviewed, and their characteristics as well as the surgical factors known to be risk factors for SSIs, were identified.
  
  
  RESULTS
  Among the 327 patients, 45 patients (13.8%) developed SSIs. The patients were divided into two groups according to the duration of antibiotic use: group S (within 24 hours) and group L (beyond 24 hours). Of the 327 patients, 114 (34.9%) were in group S, and 213 (65.1%) were in group L. Twelve patients (10.5%) in group S developed SSIs while 33 patients (15.5%) in group L developed SSIs (P = 0.242). History of diabetes mellitus and lung disease, long operation time, and perioperative transfusion were independent risk factors for SSIs.
  
  
  CONCLUSIONS
  This study shows that discontinuation of prophylactic antibiotics within 24 hours after colorectal surgery has no significant influence on the incidence of SSIs. This study also showed that history of diabetes mellitus and lung disease, long operation time, and perioperative transfusion were associated with increased SSI rates.
authors.affiliation: Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Youn Young
authors.initials: YY
authors.lastname: Park
authors.affiliation: Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Chang Woo
authors.initials: CW
authors.lastname: Kim
authors.affiliation: Department of Surgery, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Sun Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Surgery, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Kil Yeon
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Nutrition Team, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
authors.forename: Jung Joo
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Nutrition Team, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
authors.forename: Hye Ok
authors.initials: HO
authors.lastname: Lee
authors.affiliation: Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Suk-Hwan
authors.initials: SH
authors.lastname: Lee
keywords: Antibiotic prophylaxis; Colorectal surgery; Surgical wound infection
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