title: [DELAYED RESULTS OF ENZYME REPLACEMENT THERAPY, PRESCRIBED BY RESULTS OF 13C-TRIGLYCERIDE BREATH TEST].
abstract: Maldigestion persists in most patients with chronic pancreatitis (CP). The objective lipase and amylase insufficiency diagnosis is needed to achieve an adequate clinical response to oral pancreatic enzyme substitution therapy. The novel data is presented in the article about the role of 13C-mixed triglyceride breath test as a tool for exocrine pancreatic insufficiency diagnosis, for evaluating fat malabsorbtion in CP patients. 135 patients were included in the investigation. Delayed results of enzyme replacement therapy were estimated after 1 and 2 year of surveillance. It has been shown, that partial recovery of exocrine pancreatic function is possible, and replacement therapy leads to patients nutritional status improving. Thus 13C-triglyceride breath test could be useful tool in clinical practice for CP diagnosis. The test make it possible to choose the initial pancreatic enzyme dosage and are beneficial during the treatment for pancreatic enzyme dose correction.
authors.forename: V V
authors.initials: VV
authors.lastname: Chernyavskiy
authors.forename: L S
authors.initials: LS
authors.lastname: Gvozdetska
mesh_terms: D000328:Adult; D000368:Aged; D000681:Amylases / Q000172:deficiency / Q000627:therapeutic use*; D001944:Breath Tests; D016903:Drug Monitoring / Q000379:methods; D056947:Enzyme Replacement Therapy; D010188:Exocrine Pancreatic Insufficiency / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D005260:Female; D006801:Humans; D008049:Lipase / Q000172:deficiency / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology / Q000473:pathology; D050500:Pancreatitis, Chronic / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D011446:Prospective Studies; D014280:Triglycerides / Q000032:analysis* / Q000378:metabolism
chemical_list: D014280:Triglycerides; D008049:Lipase; D000681:Amylases