title: Cytoreductive surgery in the era of targeted molecular therapy.
abstract: Cytoreductive nephrectomy (CN) was regarded standard of care for patients with metastatic renal cell carcinoma (mRCC) in the immunotherapy era. With the advent of targeted molecular therapy (TMT) for the treatment of mRCC, the routine use of CN has been questioned. Up to date evidence continues to suggest that CN remains an integral part of treatment in appropriately selected patients. This review details the original context in which the efficacy of CN was established and rationale for the continued use of cytoreductive surgery in the era of TMT.
authors.affiliation: Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, USA.
authors.forename: Arun Z
authors.initials: AZ
authors.lastname: Thomas
authors.affiliation: Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, USA.
authors.forename: Mehrad
authors.initials: M
authors.lastname: Adibi
authors.affiliation: Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, USA.
authors.forename: Leonardo D
authors.initials: LD
authors.lastname: Borregales
authors.affiliation: Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, USA.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Karam
authors.affiliation: Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Wood
keywords: Cytoreductive nephrectomy (CN); kidney cancer; targeted molecular therapy (TMT); tyrosine kinase inhibitors (TKI)
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