title: Synthesis and Biological Evaluation of 2-Oxo/Thioxoquinoxaline and 2-Oxo/Thioxoquinoxaline-Based Nucleoside Analogues.
abstract: Several O- and S-quinoxaline glycosides have been prepared by glycosidation of 3-methyl-2-oxo(thioxo)-1,2-dihydroquinoxalines 1a,b with α-D-glucopyranosyl, α-D-galactopyranosyl, and α-D-lactosyl bromide in the presence of K2CO3 followed by deacetylation with Et3N/H2O. Furthermore, alkylation of 1a,b with 4-bromobutyl acetate, 2-acetoxyethoxymethyl bromide, and 3-chloropropanol afforded the corresponding O- and S-acycloquinoxaline nucleosides. Reaction of 1b with chloroacetic acid followed by condensation with sulfacetamide and sulfadiazine in the presence of Et3N/THF and ethyl chloroformate gave the corresponding sulfonamide derivatives 14 and 15, respectively. The structures of new compounds were confirmed by using IR, (1)H, (13)C NMR spectra and microanalysis. Some of these compounds were screened in vitro for antitumor and antifungal activities.
authors.affiliation: a Department of Chemistry , Faculty of Science, Zagazig University , Zagazig , Egypt.
authors.forename: Hassan A
authors.initials: HA
authors.lastname: El-Sayed
authors.affiliation: a Department of Chemistry , Faculty of Science, Zagazig University , Zagazig , Egypt.
authors.forename: Said A
authors.initials: SA
authors.lastname: Said
authors.affiliation: a Department of Chemistry , Faculty of Science, Zagazig University , Zagazig , Egypt.
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Moustafa
authors.affiliation: b Department of Medicinal Chemistry , Faculty of Pharmacy, Zagazig University , Zagazig , Egypt.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Baraka
authors.affiliation: a Department of Chemistry , Faculty of Science, Zagazig University , Zagazig , Egypt.
authors.forename: Rimaa T
authors.initials: RT
authors.lastname: Abdel-Kader
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001230:Aspergillus / Q000254:growth & development*; D001412:Bacillus subtilis / Q000254:growth & development*; D056945:Hep G2 Cells; D006801:Humans; D009711:Nucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D009711:Nucleotides; D011810:Quinoxalines
keywords: 2-Oxo(thioxo)quinoxaline; biological evaluation; cyclic/acyclic nucleosides; sulfonamide