title: EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma.
abstract: In this study, EGFR-activating mutation status and DNA copy number abundances of members of ErbB family were measured in 261 lung adenocarcinomas. The associations between DNA copy number abundances of ErbB family, EGFR-activating mutation status, and prognosis were explored. Results showed that DNA copy number abundances of EGFR, ERBB2, ERBB3, and ERBB4 had associations with overall survival in lung adenocarcinoma with EGFR-activating mutations. In the stratification analysis, only ERBB2 showed significant discrepancy in patients carrying wild type EGFR and other members of ErbB family in patients carrying EGFR-activating mutation. This indicated that CNAs of ErbB family had effect modifications of EGFR-activating mutation status. Findings of this study demonstrate potential molecular guidance of patient management of lung adenocarcinoma with or without EGFR-activating mutations.
authors.affiliation: Institute of Statistical Sciences, Academia Sinica, Taipei, Taiwan.|College of Medicine, National Taiwan University, Taipei, Taiwan.|College of Life Science, National Taiwan University, Taipei, Taiwan.
authors.forename: Hsuan-Yu
authors.initials: HY
authors.lastname: Chen
authors.affiliation: Institute of Statistical Sciences, Academia Sinica, Taipei, Taiwan.|Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.|Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chia-Hsin
authors.initials: CH
authors.lastname: Liu
authors.affiliation: Institute of Statistical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Ya-Hsuan
authors.initials: YH
authors.lastname: Chang
authors.affiliation: Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Sung-Liang
authors.initials: SL
authors.lastname: Yu
authors.affiliation: Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Bing-Ching
authors.initials: BC
authors.lastname: Ho
authors.affiliation: Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Chung-Ping
authors.initials: CP
authors.lastname: Hsu
authors.affiliation: Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Tsung-Ying
authors.initials: TY
authors.lastname: Yang
authors.affiliation: Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Kun-Chieh
authors.initials: KC
authors.lastname: Chen
authors.affiliation: Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Kuo-Hsuan
authors.initials: KH
authors.lastname: Hsu
authors.affiliation: Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Jeng-Sen
authors.initials: JS
authors.lastname: Tseng
authors.affiliation: Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Jiun-Yi
authors.initials: JY
authors.lastname: Hsia
authors.affiliation: Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Cheng-Yen
authors.initials: CY
authors.lastname: Chuang
authors.affiliation: Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Chi-Sheng
authors.initials: CS
authors.lastname: Chang
authors.affiliation: Institute of Statistical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Li
authors.affiliation: Institute of Statistical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Ker-Chau
authors.initials: KC
authors.lastname: Li
authors.affiliation: Taichung Veterans General Hospital, Taichung, Taiwan.|Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Comprehensive Cancer Center, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Gee-Chen
authors.initials: GC
authors.lastname: Chang
authors.affiliation: Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan.|Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.|Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Pan-Chyr
authors.initials: PC
authors.lastname: Yang
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D004789:Enzyme Activation / Q000235:genetics; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D005260:Female; D018628:Gene Dosage / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D008297:Male; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D020893:Receptor, ErbB-3 / Q000235:genetics*; D066247:Receptor, ErbB-4 / Q000235:genetics*
chemical_list: D066246:ErbB Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases; D020893:Receptor, ErbB-3; D066247:Receptor, ErbB-4; C512478:EGFR protein, human; C508053:ERBB2 protein, human; C581292:ERBB3 protein, human; C587689:ERBB4 protein, human
keywords: DNA copy number abundance; EGFR-activating mutation; ErbB family; lung adenocarcinoma; prognosis
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