title: A high throughput analysis of cytokines and chemokines expression during the course of Trypanosoma cruzi experimental oral infection.
abstract: Trypanosoma cruzi has high biological and biochemical diversity and variable tissue tropism. Here we aimed to verify the kinetics of cytokine and chemokine in situ secretion in animals infected with two distinct T. cruzi strains after oral inoculation. Also, we investigated parasite migration, residence and pathological damage in stomach, heart and spleen. Our results showed that host immune response against T. cruzi infection is an intricate phenomenon that depends on the parasite strain, on the infected organ and on the time point of the infection. We believe that a wide comprehension of host immune response will potentially provide basis for the development of immunotherapeutic strategies in order to clear parasitism and minimize tissue injury. In this context, we find that KC poses as a possible tool to be used.
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Adele A
authors.initials: AA
authors.lastname: Rodrigues
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Ana Flávia O
authors.initials: AF
authors.lastname: Notário
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Thaise L
authors.initials: TL
authors.lastname: Teixeira
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Rebecca T
authors.initials: RT
authors.lastname: e Silva
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Amanda P N
authors.initials: AP
authors.lastname: Quintal
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Rosiane N
authors.initials: RN
authors.lastname: Alves
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Paula C
authors.initials: PC
authors.lastname: Brígido
authors.affiliation: Faculdade de Odontologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Carla S
authors.initials: CS
authors.lastname: Siqueira
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Flávia A
authors.initials: FA
authors.lastname: Martins
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, Brazil, Brazil.
authors.forename: Fabrício C
authors.initials: FC
authors.lastname: Machado
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, Brazil, Brazil.
authors.forename: Tatiana M
authors.initials: TM
authors.lastname: Clemente
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Aline A
authors.initials: AA
authors.lastname: da Silva
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Bruna C
authors.initials: BC
authors.lastname: Borges
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Samuel C
authors.initials: SC
authors.lastname: Teixeira
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: Marlus A
authors.initials: MA
authors.lastname: dos Santos
authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. Electronic address: silva_cv@yahoo.com.br.
authors.forename: Claudio V
authors.initials: CV
authors.lastname: da Silva
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000276:immunology* / Q000469:parasitology* / Q000662:veterinary; D018925:Chemokines / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000469:parasitology; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D013154:Spleen / Q000469:parasitology; D013270:Stomach / Q000469:parasitology; D014349:Trypanosoma cruzi / Q000276:immunology*
chemical_list: D018925:Chemokines; D016207:Cytokines; D000949:Histocompatibility Antigens Class II; D012333:RNA, Messenger
keywords: Chagas disease; Chemokines; Cytokines; Immune response; Immunotherapy; Trypanosoma cruzi