title: KIF1Bβ and Neuroblastoma: Failure to Divide and Cull.
abstract: Neuroblastomas are associated with KIF1Bβ mutations within tumor suppressor region 1p36. In this issue of Developmental Cell, Li et al. (2016) show that KIF1Bβ binding releases calcineurin autoinhibition, leading to dephosphorylation of the DRP1 GTPase and subsequent mitochondrial fragmentation. KIF1Bβ impairment causes mitochondrial hyperfusion, impairing developmental apoptosis and promoting tumorigenesis.
authors.affiliation: Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 2A-201, 9000 Rockville Pike, Bethesda, MD 20892-3738, USA. Electronic address: blackstc@ninds.nih.gov.
authors.forename: Craig
authors.initials: C
authors.lastname: Blackstone
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D019703:Calcineurin / Q000235:genetics*; D020558:GTP Phosphohydrolases / Q000235:genetics*; D006801:Humans; D016547:Kinesins / Q000235:genetics*; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D063154:Mitochondrial Dynamics / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics*; D009154:Mutation / Q000235:genetics*
chemical_list: D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D019703:Calcineurin; D020558:GTP Phosphohydrolases; D016547:Kinesins
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