title: Rh(III)-Catalyzed Redox-Neutral Annulation of Primary Benzamides with Diazo Compounds: Approach to Isoquinolinones.
abstract: Reported herein is a Rh-catalyzed redox-neutral annulation of primary benzamides with diazo compounds, representing an efficient and economic protocol to isoquinolinones. The procedure exhibited good functional group tolerability, scalability, and regioselectivity, obviating the need for oxidants, and only environmentally benign N2 and H2O were released. Further utilization of the method provided an alternative route to functionalized isoquinolines.
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
authors.forename: Youzhi
authors.initials: Y
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
authors.forename: Kaifan
authors.initials: K
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
authors.forename: Tie
authors.initials: T
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
authors.forename: Hequan
authors.initials: H
authors.lastname: Yao
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin