title: Use of a Loading Dose of Vitamin D for Treatment of Vitamin D Deficiency in Patients With Intestinal Failure.
abstract: Vitamin D deficiency is common in patients with intestinal failure and short bowel syndrome who have been weaned of parenteral nutrition. Dietary supplementation with vitamin D is necessary to correct this deficiency. In certain cases, routine supplementation strategy may be ineffective. We report 3 cases of vitamin D deficiency in patients with intestinal failure who showed improvement in serum 25-hydroxyvitamin D levels after supplementation with a loading dose of 20,000-40,000 IU vitamin D provided weekly.
authors.affiliation: 1 Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Neil
authors.initials: N
authors.lastname: Grenade
authors.affiliation: 1 Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.|2 Group for Improvement of Intestinal Function and Treatment, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Christina
authors.initials: C
authors.lastname: Kosar
authors.affiliation: 1 Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.|2 Group for Improvement of Intestinal Function and Treatment, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Karen
authors.initials: K
authors.lastname: Steinberg
authors.affiliation: 1 Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.|2 Group for Improvement of Intestinal Function and Treatment, The Hospital for Sick Children, Toronto, Ontario, Canada.|3 Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Yaron
authors.initials: Y
authors.lastname: Avitzur
authors.affiliation: 1 Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.|2 Group for Improvement of Intestinal Function and Treatment, The Hospital for Sick Children, Toronto, Ontario, Canada.|4 Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Wales
authors.affiliation: 1 Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.|2 Group for Improvement of Intestinal Function and Treatment, The Hospital for Sick Children, Toronto, Ontario, Canada.|5 Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Glenda
authors.initials: G
authors.lastname: Courtney-Martin
mesh_terms: D002648:Child; D002675:Child, Preschool; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D012778:Short Bowel Syndrome / Q000150:complications / Q000188:drug therapy*; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy* / Q000209:etiology
chemical_list: D014807:Vitamin D
keywords: intestinal failure; micronutrient malabsorption; pediatrics; vitamin D