title: Post reperfusion syndrome during liver transplantation: From pathophysiology to therapy and preventive strategies.
abstract: This review aims at evaluating the existing evidence regarding post reperfusion syndrome, providing a description of the pathophysiologic mechanisms involved and possible management and preventive strategies. A PubMed search was conducted using the MeSH database, "Reperfusion" AND "liver transplantation" were the combined MeSH headings; EMBASE and the Cochrane library were also searched using the same terms. 52 relevant studies and one ongoing trial were found. The concept of post reperfusion syndrome has evolved through years to a multisystemic disorder. The implications of the main organ, recipient and procedure related factors in the genesis of this complex syndrome are discussed in the text as the novel pharmacologic and technical approaches to reduce its incidence. However the available evidence about risk factors, physiopathology and preventive measures is still confusing, the presence of two main definitions and the numerosity of possible confounding factors greatly complicates the interpretation of the studies.
authors.affiliation: Antonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Laura Lorenzini, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Siniscalchi
authors.affiliation: Antonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Laura Lorenzini, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Gamberini
authors.affiliation: Antonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Laura Lorenzini, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Laici
authors.affiliation: Antonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Laura Lorenzini, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Bardi
authors.affiliation: Antonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Laura Lorenzini, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ercolani
authors.affiliation: Antonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Laura Lorenzini, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Lorenzini
authors.affiliation: Antonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Laura Lorenzini, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Faenza
mesh_terms: D000818:Animals; D006439:Hemodynamics; D006801:Humans; D008102:Liver Circulation; D016031:Liver Transplantation / Q000009:adverse effects*; D023421:Models, Animal; D015427:Reperfusion Injury / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Drug therapy; Hemodynamics; Ischemia-reperfusion injury; Liver transplantation; Reperfusion
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