title: Resistant starch for modulation of gut microbiota: Promising adjuvant therapy for chronic kidney disease patients?
abstract: The gut microbiota has been extensively studied in all health science fields because its imbalance is linked to many disorders, such as inflammation and oxidative stress, thereby contributing to cardiovascular disease, obesity, diabetes and chronic kidney disease (CKD) complications. Novel therapeutic strategies that aim to reduce the complications caused by this imbalance have increased in recent years. Studies have shown that prebiotic supplementation can beneficially modulate the gut microbiota in CKD patients. Prebiotics consist of non-digestible dietary soluble fiber, which acts as a substrate for the gut microbiota. Resistant starch (RS) is a type of dietary fiber that can reach the large bowel and act as a substrate for microbial fermentation; for these reasons, it has been considered to be a prebiotic. Few studies have analyzed the effects of RS on the gut microbiota in CKD patients. This review discusses recent information about RS and the potential role of the gut microbiota, with a particular emphasis on CKD patients.
authors.affiliation: Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil. moraesmjc@gmail.com.
authors.forename: Cristiane
authors.initials: C
authors.lastname: Moraes
authors.affiliation: Medical Sciences Graduate Program, Federal University Fluminense (UFF), Niterói, Rio de Janeiro, Brazil.
authors.forename: Natália A
authors.initials: NA
authors.lastname: Borges
authors.affiliation: Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil.|Medical Sciences Graduate Program, Federal University Fluminense (UFF), Niterói, Rio de Janeiro, Brazil.
authors.forename: Denise
authors.initials: D
authors.lastname: Mafra
mesh_terms: D004043:Dietary Fiber / Q000008:administration & dosage; D005285:Fermentation; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D018384:Oxidative Stress; D056692:Prebiotics / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D051436:Renal Insufficiency, Chronic / Q000178:diet therapy*; D013213:Starch / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004043:Dietary Fiber; D056692:Prebiotics; D013213:Starch
keywords: Gut; Kidney disease; Microbiota; Prebiotic; Uremic toxins
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