title: Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae).
abstract: Twenty new neo-clerodane type diterpenoids, scutefolides G1-S (1-20), were isolated from the 70 % aqueous acetone extract of the aerial parts of Scutellaria coleifolia. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of 1, 2, 7, 8, 14 and 15 were determined by means of the CD exciton chirality method. Compounds 1, 2, 5, 7, 8, 12, 14, 15, 18 and 19 were evaluated for their cytotoxic activities against four human cancer cell lines, and anti-bacterial activities against methicillin-resistant Staphylococcus aureus.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78 Shomachi, Tokushima, 7708505, Japan.|Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji, 6708524, Japan.
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Kurimoto
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78 Shomachi, Tokushima, 7708505, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Shibata
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78 Shomachi, Tokushima, 7708505, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78 Shomachi, Tokushima, 7708505, Japan. kasiwada@tokushima-u.ac.jp.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kashiwada
mesh_terms: D000215:Acylation; D045744:Cell Line, Tumor; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D015394:Molecular Structure; D009369:Neoplasms; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D031363:Scutellaria / Q000737:chemistry*
chemical_list: D045785:Diterpenes, Clerodane; D010936:Plant Extracts
keywords: Diterpenoid; Lamiaceae; Scutellaria coleifolia; neo-Clerodane
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