title: [Examination of Measures for Preventing Exposure in Nurses Who Handle Cyclophosphamide].
abstract: Health hazards due to long-term exposure to anticancer drugs have been reported among health care professionals. In Yamagata Prefectural Central Hospital, constant use of personal protective equipment(gloves and mask with face shield)is mandatory, but there is no clear description of the protective gown. To verify the exposure status of nurses while handling cyclophosphamide and the usefulness of a protective gown as a protective measure, urinary concentration of cyclophosphamide was measured for nurses who handled cyclophosphamide. No cyclophosphamide was detected in the urine samples collected from nurses who handled cyclophosphamide while wearing protective gowns or in the samples collected from nurses who handled cyclophosphamide without protective gowns. This finding suggests that gloves and a mask with a face shield are sufficient for preventing exposure to cyclophosphamide. However, considering that only experienced nurses were included as subjects in this study, we cannot conclude that a protective gown is unnecessary, because inexperienced nurses may be exposed to cyclophosphamide. Our study's findings may be one reference to examine measures for preventing exposure in nurses.
authors.affiliation: Dept. of Hospital Pharmacy, Yamagata Prefectural Central Hospital.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ono
authors.forename: Yumi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Keiko
authors.initials: K
authors.lastname: Omori
authors.forename: Mikiko
authors.initials: M
authors.lastname: Matsuda
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sato
authors.forename: Eijiro
authors.initials: E
authors.lastname: Omoto
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry* / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D009726:Nurses; D016273:Occupational Exposure / Q000517:prevention & control*; D011481:Protective Clothing
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide