title: Processing of ferulic acid modified hemoglobin.
abstract: The application of hemoglobin-based oxygen carriers (HBOCs) remains stagnant because a large number of reactive oxygen species (ROS) will be produced in organisms when HBOCs are used. Ferulic acid (FA) has a known effect on quenching oxygen free radicals and relieving vasospasm. Thus a kind of FA modified hemoglobin (BAEGF-Hb) is expected to produce the anti-oxidation effect on HBOCs spontaneously, and reduce toxicity. Isoelectric focusing electrophoresis, UV-vis wavelength scanning, and oxygen affinity curve showed that hemoglobin (Hb) was successfully modified and this modification had no effect on the structure of Hb and P50. The modification degree of Hb is 4.
authors.affiliation: a School of Environmental and Chemical Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: Song
authors.initials: S
authors.lastname: Guo
authors.affiliation: a School of Environmental and Chemical Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.affiliation: a School of Environmental and Chemical Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: a School of Environmental and Chemical Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: Zhengyan
authors.initials: Z
authors.lastname: Meng
authors.forename: Donglai
authors.initials: D
authors.lastname: Qi
authors.affiliation: a School of Environmental and Chemical Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
mesh_terms: D001802:Blood Substitutes / Q000138:chemical synthesis* / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry*; D006454:Hemoglobins / Q000737:chemistry*; D006801:Humans; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry
chemical_list: D001802:Blood Substitutes; D003373:Coumaric Acids; D006454:Hemoglobins; C004999:ferulic acid; D010100:Oxygen
keywords: Blood substitute; P50; ferulic acid; hemoglobin; radical scavenger