title: A pilot study to compartmentalize small melanocytic choroidal tumors and choroidal vessels with speckle-noise free 1050 nm swept source optical coherence tomography (OCT choroidal "tumoropsy").
abstract: OBJECTIVE
  The purpose was to illustrate small melanocytic choroidal tumors with speckle-noise free swept-source optical coherence tomography (SSOCT).
  
  
  METHODS
  Twenty-five small melanocytic choroidal tumors in 24 eyes underwent 1050 nm OCT. All tumors were measured manually with the built-in caliper tool and compared to data derived from a semiautomated algorithm that removed speckle noise but preserved the structure of the tumors from the SSOCT data.
  
  
  RESULTS
  The average manual measurements for the horizontal, vertical, and axial diameters were 1535.28 μm (range, 547-2807 μm), 1713.8 μm (range, 574-3921 μm), and 227.28 μm (range, 115-489 μm), respectively. The measured average volumes of the tumors were 835,248,212 μm(3) (range, 48,818,700 to 4,567,401,810 μm(3)) and 228,588,535 μm(3) (range, 22,879,641 to 787,668,886 μm(3)) for caliper measurements, respectively, for the extracted volumes. The average volume variation between the two methods was 66.16 % (range, 46.5 % to 82.75 %). The average ratio between the caliper and extracted volumes was 3.402 (range, 1.346-8.198, SD 1.681), 2.367 (range, 1.346-3.258, SD 0.618), 2.321 (range, 1.346-3.258, SD 0.611), 2.402 (range, 1.518-3.258, SD 0.591), and 1.749 (range, 1.518-1.733, SD 0.239) for all tumors, all tumors with the exclusion of extreme parameters, tumor <3 mm, tumor <2 mm, and tumor <1 mm, respectively. The average ratio (tumor index) between the tumor volume and the choroidal vessel volume was 12.539 (range, 0.489-73.701).
  
  
  CONCLUSIONS
  Speckle-noise free swept-source OCT may be an illustrative OCT imaging technology. OCT may be useful for describing and monitoring small melanocytic choroidal tumors and the choroidal vessels.
authors.affiliation: Department of Ophthalmology, OCTlab, University of Basel, Mittlere Strasse 91, CH-4056, Basel, Switzerland. info@dr-maloca.ch.
authors.forename: Peter
authors.initials: P
authors.lastname: Maloca
authors.affiliation: Department of Ophthalmology, OCTlab, University of Basel, Mittlere Strasse 91, CH-4056, Basel, Switzerland.
authors.forename: Cyrill
authors.initials: C
authors.lastname: Gyger
authors.affiliation: Department of Ophthalmology, OCTlab, University of Basel, Mittlere Strasse 91, CH-4056, Basel, Switzerland.
authors.forename: Pascal Willy
authors.initials: PW
authors.lastname: Hasler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000098:blood supply*; D002830:Choroid Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D009508:Nevus, Pigmented / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D010865:Pilot Projects; D011446:Prospective Studies; D041623:Tomography, Optical Coherence
keywords: Choroid; Nevus; Optical coherence tomography
references.citation: Ophthalmology. 2005 Oct;112(10):1784-9
references.pmid: 16154197
references.citation: Retina. 2012 Jul;32(7):1363-72
references.pmid: 22466491
references.citation: Ophthalmology. 2013 Oct;120(10):2066-71
references.pmid: 23664467
references.citation: Transl Vis Sci Technol. 2015 Nov 17;4(6):3
references.pmid: 26629399
references.citation: Arch Ophthalmol. 1997 Dec;115(12):1537-44
references.pmid: 9400787
references.citation: Retina. 2015 Nov;35(11):2163-80
references.pmid: 26428607
references.citation: Ophthalmology. 2000 Aug;107(8):1443-9
references.pmid: 10919885
references.citation: Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7738-48
references.pmid: 21551412
references.citation: Am J Ophthalmol. 2015 Jan;159(1):169-76.e1
references.pmid: 25448319
references.citation: Ophthalmology. 2014 Aug;121(8):1572-8
references.pmid: 24755005
references.citation: Case Rep Ophthalmol. 2011 May;2(2):185-8
references.pmid: 21720534
references.citation: Invest Ophthalmol Vis Sci. 2012 Jan 25;53(1):261-6
references.pmid: 22167095
references.citation: Am J Ophthalmol. 2013 Sep;156(3):438-43.e1
references.pmid: 23677139
references.citation: Ophthalmology. 2003 May;110(5):956-61
references.pmid: 12750097
references.citation: Biomed Opt Express. 2013 Nov 11;4(12):2795-812
references.pmid: 24409381
references.citation: Clin Dermatol. 2015 Mar-Apr;33(2):183-96
references.pmid: 25704938
references.citation: Clin Ophthalmol. 2010 Jul 30;4:829-36
references.pmid: 20689737
references.citation: J Ophthalmol. 2012;2012:385058
references.pmid: 23008756
references.citation: PLoS One. 2014 Jun 09;9(6):e99690
references.pmid: 24911446
references.citation: Am J Ophthalmol. 2008 Oct;146(4):496-500
references.pmid: 18639219
references.citation: Biomed Opt Express. 2012 Jan 1;3(1):86-103
references.pmid: 22254171
references.citation: Arch Ophthalmol. 2012 Jul;130(7):850-6
references.pmid: 22776921
references.citation: Arch Ophthalmol. 1998 May;116(5):645-50
references.pmid: 9596501
references.citation: Graefes Arch Clin Exp Ophthalmol. 2016 Apr;254(4):797-808
references.pmid: 26537123
references.citation: Arch Ophthalmol. 2009 Aug;127(8):981-7
references.pmid: 19667334