title: Growth failure in adolescents: etiology, the role of pubertal timing and most useful criteria for diagnostic workup.
abstract: BACKGROUND
  The aim of the study was to evaluate the etiology, the role of pubertal timing and most useful criteria for diagnostic workup in adolescents with growth failure.
  
  
  METHODS
  Adolescents (n=182) aged 10.0-18.0 years underwent a standardized diagnostic protocol. Constitutional delay of growth and puberty (CDGP) was defined as late pubertal onset or a Tanner stage less than -2 SDS. Dutch and Finnish criteria for growth monitoring were retrospectively assessed.
  
  
  RESULTS
  In 13 children (7.1%) a specific diagnosis could be established. CDGP was diagnosed in 10% of patients aged ≥13 (girls) or ≥14 years (boys). Sensitivity to detect pathologic causes was 85% and 62% for, respectively Dutch and Finnish criteria for growth monitoring as used in younger children, but specificity was low (55%-59%).
  
  
  CONCLUSIONS
  In adolescents, pathological causes for growth failure and pubertal delay are common, and we recommend a combination of height SDS, distance to THSDS and growth deflection for deciding on further diagnostic testing.
authors.forename: Susanne E
authors.initials: SE
authors.lastname: Stalman
authors.forename: Ilse
authors.initials: I
authors.lastname: Hellinga
authors.forename: Jan M
authors.initials: JM
authors.lastname: Wit
authors.forename: Raoul C M
authors.initials: RC
authors.lastname: Hennekam
authors.forename: Gerdine A
authors.initials: GA
authors.lastname: Kamp
authors.forename: Frans B
authors.initials: FB
authors.lastname: Plötz
mesh_terms: D000293:Adolescent; D001827:Body Height; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011628:Puberty, Delayed / Q000175:diagnosis* / Q000209:etiology*; D012741:Sexual Maturation / Q000502:physiology*; D013997:Time Factors