title: Two new phragmalin-type limonoids from Chukrasia tabularis and their α-glucosidase inhibitory activity.
abstract: Phytochemical investigation on the stems of C. tabularis (Meliaceae) led to the isolation of two new phragmalin-type limonoids, named tabularisins S and T (1-2), along with five known ones (3-7). The structures of the new limonoids were established by spectroscopic methods including UV, IR, HRESIMS, and 1D and 2D NMR. All the compounds were evaluated for α-glucosidase inhibitory activity in vitro. Compounds 2 and 3 exhibited significant inhibitory activity against α-glucosidase with IC50 values of 0.15 and 0.03 mM, respectively (acarbose as positive control, IC50 0.95 mM).
authors.affiliation: a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture , National Center of Important Tropical Crops Engineering and Technology Research, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.|b College of Pharmacy and Chemistry , Dali University , Dali 671000 , China.
authors.forename: Jun-Lin
authors.initials: JL
authors.lastname: Peng
authors.affiliation: a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture , National Center of Important Tropical Crops Engineering and Technology Research, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture , National Center of Important Tropical Crops Engineering and Technology Research, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.affiliation: a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture , National Center of Important Tropical Crops Engineering and Technology Research, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Fan-Dong
authors.initials: FD
authors.lastname: Kong
authors.affiliation: b College of Pharmacy and Chemistry , Dali University , Dali 671000 , China.
authors.forename: Zi-Qi
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture , National Center of Important Tropical Crops Engineering and Technology Research, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture , National Center of Important Tropical Crops Engineering and Technology Research, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Cui-Juan
authors.initials: CJ
authors.lastname: Gai
authors.affiliation: b College of Pharmacy and Chemistry , Dali University , Dali 671000 , China.
authors.forename: Bei
authors.initials: B
authors.lastname: Jiang
authors.affiliation: a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture , National Center of Important Tropical Crops Engineering and Technology Research, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D000520:alpha-Glucosidases / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal; D065089:Glycoside Hydrolase Inhibitors; D036701:Limonins; C000593079:phragmalin; C000613287:tabularisin S; C000613288:tabularisin T; D000520:alpha-Glucosidases
keywords: Chukrasia tabularis; Meliaceae; limonoid; α-glucosidase activity