title: Chemotaxis during neural crest migration.
abstract: Chemotaxis refers to the directional migration of cells towards external, soluble factors along their gradients. It is a process that is used by many different cell types during development for tissue organisation and the formation of embryonic structures, as well as disease like cancer metastasis. The neural crest (NC) is a multipotent, highly migratory cell population that contribute to a range of tissues. It has been hypothesised that NC migration, at least in part, is reliant on chemotactic signals. This review will explore the current evidence for proposed chemoattractants of NC cells, and outline mechanisms for the chemotactic response of the NC to them.
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Adam
authors.initials: A
authors.lastname: Shellard
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: r.mayor@ucl.ac.uk.
authors.forename: Roberto
authors.initials: R
authors.lastname: Mayor
mesh_terms: D000818:Animals; D002630:Chemotactic Factors / Q000494:pharmacology; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D008954:Models, Biological; D009432:Neural Crest / Q000166:cytology* / Q000187:drug effects
chemical_list: D002630:Chemotactic Factors
keywords: C3/C3aR; Chemotaxis; Collective migration; Neural crest; SDF1/CXCL12; VEGF