title: Infective endocarditis: Clinical presentation, etiology, and early predictors of in-hospital case fatality.
abstract: OBJECTIVE
  We aimed to assess the clinical presentation, microbial etiology and outcome of patients presenting with infective endocarditis (IE).
  
  
  METHODS
  We conducted a four-year retrospective study including all patients presenting with IE.
  
  
  RESULTS
  We included 121 patients in the study. The median age was 74.8years. Most patients had native valve IE (57%). Staphylococcus aureus accounted for 24.8% of all IE. Surgery was indicated for 70 patients (57.9%) but actually performed in only 55 (44.7%). Factors associated with surgery were younger age (P=0.002) and prosthetic valve IE (P=0.001). Risk factors associated with in-hospital mortality were diabetes mellitus (OR=3.17), chronic renal insufficiency (OR=6.62), and surgical indication (OR=3.49). Mortality of patients who underwent surgery was one sixth of that of patients with surgical indication who did not have the surgery (P<0.001).
authors.affiliation: Équipe mobile de microbiologie clinique, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France. Electronic address: bpilmis@hpsj.fr.
authors.forename: B
authors.initials: B
authors.lastname: Pilmis
authors.affiliation: Laboratoire de microbiologie clinique et dosage des anti-infectieux, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Mizrahi
authors.affiliation: Laboratoire de microbiologie clinique et dosage des anti-infectieux, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Laincer
authors.affiliation: Équipe mobile de microbiologie clinique, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France; Équipe opérationnelle d'hygiène, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Couzigou
authors.affiliation: Laboratoire de microbiologie clinique et dosage des anti-infectieux, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: El Helali
authors.affiliation: Laboratoire de microbiologie clinique et dosage des anti-infectieux, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Nguyen Van
authors.affiliation: Service de cardiologie, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Abassade
authors.affiliation: Service de cardiologie, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Cador
authors.affiliation: Laboratoire de microbiologie clinique et dosage des anti-infectieux, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Le Monnier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000706:statistics & numerical data; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D004617:Embolism / Q000453:epidemiology / Q000209:etiology; D004696:Endocarditis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery; D005260:Female; D005602:France; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000706:statistics & numerical data; D017052:Hospital Mortality; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D011379:Prognosis; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents
keywords: Endocardite infectieuse; Epidemiology; Infective endocarditis; Épidémiologie