title: Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population.
abstract: BACKGROUND
  The relationship between the apolipoprotein E (APOE) polymorphism and intracranial aneurysms has previously only been studied in Russia and Japan but not in Chinese populations. The purpose of this study was to investigate the association between APOE polymorphism and the risk of intracranial aneurysms in a Chinese population.
  
  
  METHODS
  The study population consisted of 150 intracranial aneurysms patients and 150 matched control subjects. The APOE gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  Patients with intracranial aneurysms had a significantly higher frequency of APOE E2/E2 genotype [odds ratio (OR) = 9.51, 95% confidence interval (CI) = 1.19, 76.04; P = 0.03] and APOE E2/E3 genotype (OR = 1.87, 95% CI = 1.03, 3.40; P = 0.04) than healthy controls. The APOE E4/E4 genotype frequencies (OR = 0.09, 95% CI = 0.01, 0.74; P = 0.03) in the intracranial aneurysms group were significantly lower than those in the controls group. When stratified by the site, shape, size and the Fisher Grade of intracranial aneurysms, no statistically significant result was observed.
  
  
  CONCLUSIONS
  Our study suggested that APOE polymorphism might be associated with intracranial aneurysms in Chinese population. Additional studies are needed to confirm this finding.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiao Tong University, West Yanta Road No.277, Xi'an, 710061, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiao Tong University, West Yanta Road No.277, Xi'an, 710061, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Mao
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiao Tong University, West Yanta Road No.277, Xi'an, 710061, China.
authors.forename: Changhou
authors.initials: C
authors.lastname: Xie
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiao Tong University, West Yanta Road No.277, Xi'an, 710061, China.
authors.forename: Wanfu
authors.initials: W
authors.lastname: Xie
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiao Tong University, West Yanta Road No.277, Xi'an, 710061, China.
authors.forename: Maode
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiao Tong University, West Yanta Road No.277, Xi'an, 710061, China. haitjiang@hotmail.com.
authors.forename: Haitao
authors.initials: H
authors.lastname: Jiang
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D002532:Intracranial Aneurysm / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D001057:Apolipoproteins E
references.citation: Stroke. 1999 Dec;30(12):2612-6
references.pmid: 10582986
references.citation: Ann Neurol. 2000 Sep;48(3):297-303
references.pmid: 10976635
references.citation: Stroke. 2001 Jul;32(7):1499-507
references.pmid: 11441192
references.citation: Am J Epidemiol. 2002 Mar 15;155(6):487-95
references.pmid: 11882522
references.citation: J Biol Chem. 2002 Aug 16;277(33):29919-26
references.pmid: 12042316
references.citation: Stroke. 2003 Jun;34(6):1375-81
references.pmid: 12764233
references.citation: Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):284-9
references.pmid: 14688411
references.citation: Science. 1994 May 6;264(5160):850-2
references.pmid: 8171342
references.citation: J Biol Chem. 1995 Nov 10;270(45):27063-71
references.pmid: 7592957
references.citation: Stroke. 1998 Jan;29(1):251-6
references.pmid: 9445359
references.citation: J Neurosci. 1999 Jun 15;19(12):4867-80
references.pmid: 10366621
references.citation: J Biol Chem. 1999 Oct 15;274(42):30001-7
references.pmid: 10514484
references.citation: Neuroreport. 2004 Dec 3;15(17):2655-8
references.pmid: 15570172
references.citation: Lancet Neurol. 2005 Mar;4(3):179-89
references.pmid: 15721828
references.citation: Stroke. 2006 May;37(5):1189-94
references.pmid: 16574921
references.citation: J Neurosurg. 2006 Sep;105(3):418-23
references.pmid: 16961137
references.citation: Neurosurgery. 2007 Feb;60(2):213-25; discussion 225-6
references.pmid: 17290171
references.citation: Stroke. 2007 Oct;38(10):2670-6
references.pmid: 17761919
references.citation: Zh Nevrol Psikhiatr Im S S Korsakova. 2007;107(10):52-7
references.pmid: 18477980
references.citation: J Neurosurg. 2010 Apr;112(4):714-21
references.pmid: 19780647
references.citation: Nat Genet. 2010 May;42(5):420-5
references.pmid: 20364137
references.citation: Ann Neurol. 2010 Dec;68(6):934-43
references.pmid: 21061402
references.citation: Hum Mol Genet. 2012 May 1;21(9):2102-10
references.pmid: 22286173
references.citation: Neurosci Lett. 2012 Apr 11;514(1):6-11
references.pmid: 22381401
references.citation: Clin Dev Immunol. 2012;2012:567586
references.pmid: 22844323
references.citation: Mol Biol Rep. 2012 Oct;39(10):9347-54
references.pmid: 22760259
references.citation: Gene. 2012 Dec 10;511(1):12-7
references.pmid: 22982410
references.citation: Mol Biol Rep. 2012 Dec;39(12):11217-23
references.pmid: 23065210
references.citation: Arch Med Res. 2013 Jan;44(1):46-53
references.pmid: 23142524
references.citation: PLoS One. 2013;8(3):e57022
references.pmid: 23483893
references.citation: J Hum Hypertens. 2013 Apr;27(4):245-55
references.pmid: 22971752
references.citation: Int J Neurosci. 2013 Jul;123(7):454-8
references.pmid: 23294012
references.citation: Neurol India. 2013 May-Jun;61(3):293-9
references.pmid: 23860151
references.citation: Genet Test Mol Biomarkers. 2013 Aug;17(8):620-4
references.pmid: 23675986
references.citation: J Int Med Res. 2013 Aug;41(4):1079-87
references.pmid: 23847294
references.citation: Lipids Health Dis. 2013;12:120
references.pmid: 23919842
references.citation: J Neural Transm (Vienna). 2013 Oct;120(10):1479-89
references.pmid: 23571734
references.citation: Alzheimers Dement. 2013 Nov;9(6):706-13
references.pmid: 23688578
references.citation: Hum Immunol. 2013 Dec;74(12):1679-83
references.pmid: 23993981
references.citation: J Assist Reprod Genet. 2013 Dec;30(12):1547-52
references.pmid: 24141900
references.citation: Lipids Health Dis. 2013;12:155
references.pmid: 24160669
references.citation: Lipids Health Dis. 2014;13:21
references.pmid: 24456740
references.citation: J Stroke Cerebrovasc Dis. 2014 Feb;23(2):356-60
references.pmid: 23800505
references.citation: Lipids Health Dis. 2014;13:40
references.pmid: 24571688
references.citation: Stroke. 2014 Nov;45(11):3194-9
references.pmid: 25256182