title: Progesterone After Estradiol Modulates Shuttle-Cage Escape by Facilitating Volition.
abstract: In animal models of depression, depression is defined as performance on a learning task. That task is typically escaping a mild electric shock in a shuttle cage by moving from one side of the cage to the other. Ovarian hormones influence learning in other kinds of tasks, and these hormones are associated with depressive symptoms in humans. The role of these hormones in shuttle-cage escape learning, however, is less clear. This study manipulated estradiol and progesterone in ovariectomized female rats to examine their performance in shuttle-cage escape learning without intentionally inducing a depressive-like state. Progesterone, not estradiol, within four hours of testing affected latencies to escape. The improvement produced by progesterone was in the decision to act, not in the speed of learning or speed of escaping. This parallels depression in humans in that depressed people are slower in volition, in their decisions to take action.
authors.affiliation: Department of Psychology, St. Bonaventure University, St. Bonaventure, NY, USA.
authors.forename: Darryl J
authors.initials: DJ
authors.lastname: Mayeaux
authors.affiliation: Department of Psychology, St. Bonaventure University, St. Bonaventure, NY, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Tandle
authors.affiliation: Department of Psychology, St. Bonaventure University, St. Bonaventure, NY, USA.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Cilano
authors.affiliation: Department of Psychology, St. Bonaventure University, St. Bonaventure, NY, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Fitzharris
keywords: depression; learned helplessness; learning; volition
references.citation: J Comp Physiol Psychol. 1967 Feb;63(1):28-33
references.pmid: 6029715
references.citation: Behav Brain Res. 2008 Feb 11;187(1):56-66
references.pmid: 17913254
references.citation: Anim Behav. 2009 Aug;78(2):279-286
references.pmid: 22408275
references.citation: Behav Neurosci. 2001 Apr;115(2):384-93
references.pmid: 11345963
references.citation: Pharmacol Biochem Behav. 1999 Dec;64(4):803-12
references.pmid: 10593204
references.citation: Behav Neurosci. 1997 Apr;111(2):259-66
references.pmid: 9106666
references.citation: Biol Psychiatry. 1987 Mar;22(3):313-24
references.pmid: 3814680
references.citation: Behav Brain Res. 2009 Aug 12;201(2):257-64
references.pmid: 19428642
references.citation: Eur J Pharmacol. 1997 Apr 23;325(1):1-7
references.pmid: 9151931
references.citation: Arch Gynecol Obstet. 2008 Oct;278(4):299-307
references.pmid: 18592262
references.citation: Horm Behav. 2005 Jun;48(1):23-33
references.pmid: 15919382
references.citation: Behav Neurosci. 2004 Apr;118(2):306-13
references.pmid: 15113256
references.citation: Neurobiol Learn Mem. 2008 Jul;90(1):171-7
references.pmid: 18455450
references.citation: Behav Pharmacol. 2009 Oct;20(7):614-22
references.pmid: 19752723
references.citation: Psychoneuroendocrinology. 2007 Jul;32(6):651-9
references.pmid: 17561352
references.citation: Pharmacol Biochem Behav. 2004 Jul;78(3):531-40
references.pmid: 15251262
references.citation: Behav Neurosci. 1997 Apr;111(2):267-74
references.pmid: 9106667
references.citation: Horm Behav. 2002 Nov;42(3):284-93
references.pmid: 12460588
references.citation: Biol Psychol. 2001 Nov;58(2):147-58
references.pmid: 11600242
references.citation: J Gen Psychol. 2008 Jul;135(3):271-86
references.pmid: 18649493
references.citation: Horm Behav. 2000 Dec;38(4):234-42
references.pmid: 11104641
references.citation: Physiol Behav. 1989 Apr;45(4):781-7
references.pmid: 2780848
references.citation: Ann N Y Acad Sci. 2005 Jun;1052:152-69
references.pmid: 16024758
references.citation: Can J Physiol Pharmacol. 2008 Oct;86(10):726-35
references.pmid: 18841177
references.citation: Behav Neurosci. 2001 Feb;115(1):229-37
references.pmid: 11256446
references.citation: Neurobiol Learn Mem. 1995 Jul;64(1):83-96
references.pmid: 7582815
references.citation: Physiol Behav. 1990 Oct;48(4):571-6
references.pmid: 2075210
references.citation: Physiol Behav. 2009 Jan 8;96(1):91-7
references.pmid: 18793660
references.citation: Neurobiol Aging. 2009 Jun;30(6):932-45
references.pmid: 17950954
references.citation: Pharmacol Biochem Behav. 1989 Jul;33(3):649-54
references.pmid: 2587607
references.citation: Physiol Behav. 1993 Dec;54(6):1119-24
references.pmid: 8295951
references.citation: Pharmacol Biochem Behav. 2000 Nov;67(3):587-96
references.pmid: 11164090
references.citation: Neuropsychopharmacology. 2008 Jun;33(7):1559-69
references.pmid: 17712351
references.citation: Physiol Behav. 2009 May 25;97(2):250-8
references.pmid: 19275906
references.citation: J Affect Disord. 2006 Feb;90(2-3):149-61
references.pmid: 16364451
references.citation: Brain Res. 1979 Mar 23;164:165-75
references.pmid: 570871
references.citation: Climacteric. 2008 Jun;11(3):212-20
references.pmid: 18568786
references.citation: J Affect Disord. 2003 Mar;74(1):85-96
references.pmid: 12646301
references.citation: Horm Behav. 2008 Aug;54(3):455-62
references.pmid: 18585714
references.citation: Neurobiol Learn Mem. 2008 Jan;89(1):17-26
references.pmid: 17988898
references.citation: Psychoneuroendocrinology. 1996 Oct;21(7):609-20
references.pmid: 9044444
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(2):249-55
references.pmid: 1871325
references.citation: Integr Physiol Behav Sci. 2002 Jan-Mar;37(1):4-8
references.pmid: 12069364
references.citation: Brain Res. 2002 May 3;934(2):125-31
references.pmid: 11955475
references.citation: Brain Res. 2004 Apr 9;1004(1-2):116-24
references.pmid: 15033426
references.citation: Neurosci Lett. 2008 May 30;437(2):116-20
references.pmid: 18439758
references.citation: J Exp Psychol. 1967 May;74(1):1-9
references.pmid: 6032570
references.citation: Horm Behav. 2000 Feb;37(1):86-95
references.pmid: 10712861
references.citation: Horm Behav. 2006 Mar;49(3):303-14
references.pmid: 16140300
references.citation: Neurobiol Learn Mem. 2004 Sep;82(2):142-9
references.pmid: 15341799
references.citation: Neurosci Biobehav Rev. 2004 Mar;28(1):55-63
references.pmid: 15036933
references.citation: Neuropsychiatry Neuropsychol Behav Neurol. 1998 Jul;11(3):111-9
references.pmid: 9742509
references.citation: Pharmacol Biochem Behav. 2006 May;84(1):112-9
references.pmid: 16759685
references.citation: Brain Res. 1993 Jan 22;601(1-2):241-5
references.pmid: 8381698
references.citation: Physiol Behav. 2009 May 25;97(2):239-49
references.pmid: 19275910
references.citation: Behav Brain Res. 2008 Dec 12;194(2):174-80
references.pmid: 18687366
references.citation: Neurobiol Aging. 2007 Apr;28(4):602-10
references.pmid: 16621169
references.citation: J Abnorm Psychol. 1948 Apr;43(2):193-200
references.pmid: 18861379
references.citation: J Clin Exp Neuropsychol. 1997 Aug;19(4):587-603
references.pmid: 9342691
references.citation: Eur J Neurosci. 2006 Jul;24(1):229-42
references.pmid: 16882019
references.citation: Arch Med Res. 1999 Jul-Aug;30(4):286-9
references.pmid: 10573629
references.citation: Horm Behav. 2002 May;41(3):306-15
references.pmid: 11971664
references.citation: Iran Biomed J. 2008 Apr;12(2):123-8
references.pmid: 18506219
references.citation: Mol Psychiatry. 2004 May;9(5):531-8
references.pmid: 14569273
references.citation: Int Rev Neurobiol. 2005;67:73-94
references.pmid: 16291020