title: Influence of Educational Level, Stage, and Histological Type on Survival of Oral Cancer in a Brazilian Population: A Retrospective Study of 10 Years Observation.
abstract: The mortality rate associated with oral cancer is estimated at approximately 12,300 deaths per year, and the survival rate is only 40% to 50% for diagnosed patients and is closely related to the duration of time between disease perception and its diagnosis and treatment. Socioeconomic risk factors are determinants of the incidence and mortality related to oral cancer. We conducted a retrospective, cross-sectional study of 573 records of patients with oral cancer at Haroldo Juaçaba Hospital - Cancer Institute of Ceará from 2000 to 2009 to evaluate the influence of socioeconomic factors on survival and epidemiological behavior of this neoplasia in a Brazilian population. In this study, patients with oral cancer were males greater than 60 years of age, presented squamous cell carcinoma in the floor of mouth and were characterized by low education levels. A total of 573 lesions were found in oral cavities. Cox proportional hazards regression model showed that the histological type, tumor stage, and low degree of education significantly influenced survival. A lower patient survival rate was correlated with a more advanced stage of disease and a worse prognosis. Squamous cell carcinoma is associated with a higher mortality when compared with other histological types of malign neoplasia.
authors.affiliation: From the Laboratory of Oral Pathology, Federal University of Ceará (TSD, PGDBS); Ceará School of Oncology, Haroldo Juaçaba Hospital (EFS, MDPDC, FBS); Division of Diplomacy Health (ASWDA); Division of Oral Radiology and Imaginology (FWGS); Laboratory of Oral Pathology (MRLM, APNNA); and Laboratory of Oral Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil (FBS).
authors.forename: Thinali Sousa
authors.initials: TS
authors.lastname: Dantas
authors.forename: Paulo Goberlânio
authors.initials: PG
authors.lastname: de Barros Silva
authors.forename: Eric Fernandes
authors.initials: EF
authors.lastname: Sousa
authors.forename: Maria do Pss
authors.initials: MDP
authors.lastname: da Cunha
authors.forename: Andréa Silvia Walter
authors.initials: ASW
authors.lastname: de Aguiar
authors.forename: Fábio Wildson Gurgel
authors.initials: FWG
authors.lastname: Costa
authors.forename: Mário Rogério Lima
authors.initials: MRL
authors.lastname: Mota
authors.forename: Ana Paula Negreiros Nunes
authors.initials: APNN
authors.lastname: Alves
authors.forename: Fabrício Bitu
authors.initials: FB
authors.lastname: Sousa
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012923:Social Class; D015996:Survival Rate
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