title: Expression and clinical significance of IL-17 and IL-17 receptor in ulcerative colitis.
abstract: The purpose of this study was to determine the expression levels of IL-17 in serum and IL-17 receptor (IL-17R) in intestinal mucosa tissue in patients with ulcerative colitis (UC) and controls, and evaluate their relationship with disease activity and explore the role of IL-17 in the patho-genesis of UC. A total of 36 Chinese UC patients and 60 healthy controls were enrolled in this study. Serum IL-17 and C-reactive protein (CRP) levels were determined by ELISA and immunonephelometry, respectively. The IL-17R mRNA expression levels were detected by quantitative PCR. Serum IL-17 levels were significantly elevated in UC patients as compared with those in the healthy controls (P<0.05). Among UC patients, serum IL-17 levels were significantly increased in active phase as compared with those in inactive phase (P<0.05), and correlated with CRP levels (r=0.578, P<0.01). IL-17R expression levels were higher in active UC patients than in healthy controls (P<0.05). It was concluded that IL-17 levels were highly expressed in UC, especially in active phase, and correlated with CRP levels in UC patients.
authors.affiliation: Department of Gastroenterology, Zhongnan Hospital of Wuhan University; Clinical Research Center for Intestinal & Colorectal Diseases of Hubei Province, and Key Laboratory of Allergy and Immune-related Diseases, Wuhan, 430071, China.|Department of Gastroenterology, the Central Hospital of Wuhan, Wuhan, 430014, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Zhongnan Hospital of Wuhan University; Clinical Research Center for Intestinal & Colorectal Diseases of Hubei Province, and Key Laboratory of Allergy and Immune-related Diseases, Wuhan, 430071, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xia
authors.affiliation: Department of Gastroenterology, Zhongnan Hospital of Wuhan University; Clinical Research Center for Intestinal & Colorectal Diseases of Hubei Province, and Key Laboratory of Allergy and Immune-related Diseases, Wuhan, 430071, China. 15071178164@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Zhongnan Hospital of Wuhan University; Clinical Research Center for Intestinal & Colorectal Diseases of Hubei Province, and Key Laboratory of Allergy and Immune-related Diseases, Wuhan, 430071, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology, the Central Hospital of Wuhan, Wuhan, 430014, China.
authors.forename: Zhi-Tao
authors.initials: ZT
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Zhongnan Hospital of Wuhan University; Clinical Research Center for Intestinal & Colorectal Diseases of Hubei Province, and Key Laboratory of Allergy and Immune-related Diseases, Wuhan, 430071, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhou
authors.affiliation: Department of Gastroenterology, Zhongnan Hospital of Wuhan University; Clinical Research Center for Intestinal & Colorectal Diseases of Hubei Province, and Key Laboratory of Allergy and Immune-related Diseases, Wuhan, 430071, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000097:blood; D053722:Receptors, Interleukin-17 / Q000235:genetics / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D020381:Interleukin-17; D012333:RNA, Messenger; D053722:Receptors, Interleukin-17; D002097:C-Reactive Protein
keywords: interleukin-17; interleukin-17 receptor; intestinal mucosa; serum; ulcerative colitis
references.citation: J Immunol. 2006 Jul 1;177(1):566-73
references.pmid: 16785554
references.citation: J Clin Invest. 2007 Mar;117(3):514-21
references.pmid: 17332878
references.citation: Gut. 2006 Jun;55(6):749-53
references.pmid: 16698746
references.citation: J Clin Invest. 2004 May;113(10):1490-7
references.pmid: 15146247
references.citation: J Exp Med. 2008 Dec 22;205(13):3145-58
references.pmid: 19075290
references.citation: World J Gastroenterol. 2008 Sep 7;14(33):5154-61
references.pmid: 18777592
references.citation: Annu Rev Immunol. 2009;27:485-517
references.pmid: 19132915
references.citation: J Exp Med. 2008 May 12;205(5):1063-75
references.pmid: 18411338
references.citation: Gut. 2009 Dec;58(12):1629-36
references.pmid: 19740775
references.citation: Gastroenterology. 2011 Mar;140(3):957-65
references.pmid: 21147109
references.citation: Inflamm Bowel Dis. 2011 Apr;17(4):963-70
references.pmid: 20629092
references.citation: J Immunol. 1996 Aug 1;157(3):1261-70
references.pmid: 8757634
references.citation: Gastroenterology. 2007 Jun;132(7):2359-70
references.pmid: 17570211
references.citation: Nat Immunol. 2009 Jun;10(6):603-9
references.pmid: 19448631
references.citation: Arthritis Res Ther. 2013 Aug 23;15(4):R97
references.pmid: 23968496
references.citation: Gut. 2003 Jan;52(1):65-70
references.pmid: 12477762
references.citation: Inflamm Bowel Dis. 2006 May;12(5):382-8
references.pmid: 16670527
references.citation: World J Gastroenterol. 2008 Jan 21;14(3):390-400
references.pmid: 18200661
references.citation: Gut. 2008 Dec;57(12):1682-9
references.pmid: 18653729
references.citation: Annu Rev Immunol. 2010;28:573-621
references.pmid: 20192811
references.citation: Clin Dev Immunol. 2012;2012:187258
references.pmid: 22262980
references.citation: Gastroenterology. 2000 Jun;118(6):1001-11
references.pmid: 10833473