title: Two separated thrombi in deep veins associated with pulmonary embolism after Mycoplasma pneumoniae infection: a case in adolescent female.
abstract: Mycoplasma pneumoniae is a common pathogen for respiratory infection in children, and vascular complication is one of the rarest extrapulmonary complications but with serious consequences. We report a twelve-year-old Chinese female presenting with fever, dry cough, and chest pain aggravated by respiration. She was diagnosed pneumonia due to Mycoplasma pneumoniae and treated with Azithromycin until unexpected tachypnea and swelling in the right lower limb happened. Then ultrasonic examination had revealed two separated thrombi in deep veins before pulmonary embolism was found. Finally she was cured by anticoagulation and immunosuppressive therapy. Though the mechanism of thrombosis after Mycoplasma pneumoniae infection remains unknown, the positive finding in anticardiolipin antibody as well as multi-site thromboses gives a strong hint to immune modulation. Thrombosis should be considered for those who have significantly increased C-reactive protein and positive anticardiolipin antibody after Mycoplasma pneumoniae infection. To our knowledge, this is the first report describing two unattached thrombi in deep veins associated with pulmonary embolism after Mycoplasma pneumonia infection.
authors.affiliation: Department of Pediatrics, Zhongshan Hospital Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Zhongshan Hospital Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Pediatrics, Zhongshan Hospital Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Zhongshan Hospital Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Pediatrics, Zhongshan Hospital Xiamen University, Xiamen, Fujian 361004, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Tian
keywords: Thrombosis; deep vein; mycoplasma pneumoniae; pulmonary embolism
references.citation: J Infect Chemother. 2010 Jun;16(3):162-9
references.pmid: 20186455
references.citation: South Med J. 2007 Feb;100(2):215-7
references.pmid: 17330697
references.citation: Turk J Pediatr. 2006 Apr-Jun;48(2):166-71
references.pmid: 16848121
references.citation: Pediatr Pulmonol. 2008 Feb;43(2):200-2
references.pmid: 18041082
references.citation: Postgrad Med J. 1990 May;66(775):356-62
references.pmid: 2371184
references.citation: Interact Cardiovasc Thorac Surg. 2010 Dec;11(6):849-51
references.pmid: 20847069
references.citation: Clin Infect Dis. 2001 Nov 15;33(10):E119-21
references.pmid: 11595996
references.citation: Pediatrics. 2007 Jan;119(1):e292-5
references.pmid: 17178923
references.citation: Lupus. 2006;15(2):105-6
references.pmid: 16539282
references.citation: J Natl Med Assoc. 2009 Sep;101(9):956-8
references.pmid: 19806855
references.citation: Chest. 2012 Feb;141(2 Suppl):e737S-801S
references.pmid: 22315277