title: The MCM Helicase Motor of the Eukaryotic Replisome.
abstract: The MCM motor of the CMG helicase powers ahead of the eukaryotic replication machinery to unwind DNA, in a process that requires ATP hydrolysis. The reconstitution of DNA replication in vitro has established the succession of events that lead to replication origin activation by the MCM and recent studies have started to elucidate the structural basis of duplex DNA unwinding. Despite the exciting progress, how the MCM translocates on DNA remains a matter of debate.
authors.affiliation: Architecture and Dynamics of Macromolecular Machines, Clare Hall Laboratory, The Francis Crick Institute, Blanche Lane, South Mimms EN6 3LD, United Kingdom.
authors.forename: Ferdos
authors.initials: F
authors.lastname: Abid Ali
authors.affiliation: Architecture and Dynamics of Macromolecular Machines, Clare Hall Laboratory, The Francis Crick Institute, Blanche Lane, South Mimms EN6 3LD, United Kingdom. Electronic address: alessandro.costa@crick.ac.uk.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Costa
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D004265:DNA Helicases / Q000737:chemistry* / Q000378:metabolism*; D004261:DNA Replication; D056890:Eukaryota / Q000201:enzymology* / Q000378:metabolism; D006868:Hydrolysis; D064110:Minichromosome Maintenance Proteins / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D000255:Adenosine Triphosphate; D004265:DNA Helicases; D064110:Minichromosome Maintenance Proteins
keywords: AAA+ ATPase; DNA replication; MCM helicase; molecular motor; replication origin activation