title: Superstable Magnetic Nanoparticles in Conjugation with Near-Infrared Dye as a Multimodal Theranostic Platform.
abstract: Near-infrared (NIR) dyes functionalized magnetic nanoparticles (MNPs) have been widely applied in magnetic resonance imaging (MRI), NIR fluorescence imaging, drug delivery, and magnetic hyperthermia. However, the stability of MNPs and NIR dyes in water is a key problem to be solved for long-term application. In this study, a kind of superstable iron oxide nanoparticles was synthesized by a facile way, which can be used as T1 and T2 weighted MRI contrast agent. IR820 was grafted onto the surface of nanoparticles by 6-amino hexanoic acid to form IR820-CSQ-Fe conjugates. Attached IR820 showed increased stability in water at least for three months and an enhanced ability of singlet oxygen production of almost double that of free dyes, which will improve its efficiency for photodynamic therapy. Meanwhile, the multispectral optoacoustic tomography (MSOT) and NIR imaging ability of IR820-CSQ-Fe will greatly increase the accuracy of disease detection. All of these features will broaden the application of this material as a multimodal theranostic platform.
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.
authors.forename: Huige
authors.initials: H
authors.lastname: Zhou
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Hou
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.|School of Material Science and Engineering, University of Science and Technology Beijing , Beijing 100083, P.R. China.
authors.forename: Tianming
authors.initials: T
authors.lastname: Zhao
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.|School of Material Science and Engineering, University of Science and Technology Beijing , Beijing 100083, P.R. China.
authors.forename: Qiuyu
authors.initials: Q
authors.lastname: Shang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.
authors.forename: Jinglong
authors.initials: J
authors.lastname: Tang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.|School of Material Science and Engineering, University of Science and Technology Beijing , Beijing 100083, P.R. China.
authors.forename: Qiuchi
authors.initials: Q
authors.lastname: Wu
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.|School of Material Science and Engineering, University of Science and Technology Beijing , Beijing 100083, P.R. China.
authors.forename: Zehao
authors.initials: Z
authors.lastname: Luo
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.|School of Material Science and Engineering, University of Science and Technology Beijing , Beijing 100083, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P.R. China.|School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University , Suzhou, Jiangsu 215000, China.
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
mesh_terms: D045744:Cell Line, Tumor; D003287:Contrast Media / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007208:Indocyanine Green / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D057054:Molecular Imaging / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods; D061848:Optical Imaging / Q000379:methods; D010778:Photochemotherapy / Q000379:methods; D000068936:Theranostic Nanomedicine
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C541053:IR 820; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D007208:Indocyanine Green
keywords: NIR dyes; enhanced photodynamic therapy; magnetic nanoparticles; multimodal imaging; stability