title: Nutrition and lifestyle in healthy aging: the telomerase challenge.
abstract: Nutrition and lifestyle, known to modulate aging process and age-related diseases, might also affect telomerase activity. Short and dysfunctional telomeres rather than average telomere length are associated with longevity in animal models, and their rescue by telomerase maybe sufficient to restore cell and organismal viability. Improving telomerase activation in stem cells and potentially in other cells by diet and lifestyle interventions may represent an intriguing way to promote health-span in humans.
authors.affiliation: Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
authors.forename: Virginia
authors.initials: V
authors.lastname: Boccardi
authors.affiliation: Department of Medical, Surgical, Neurological, Aging and Metabolic Sciences, Second University of Naples, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
authors.affiliation: Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Mecocci
mesh_terms: D000367:Age Factors; D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D049109:Cell Proliferation; D016922:Cellular Senescence; D004789:Enzyme Activation; D006801:Humans; D008019:Life Style; D009752:Nutritional Status; D040242:Risk Reduction Behavior; D013234:Stem Cells / Q000201:enzymology; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000235:genetics / Q000378:metabolism*; D059505:Telomere Homeostasis
chemical_list: D019098:Telomerase
keywords: elderly; longevity; nutrition; telomerase; telomere
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