title: Whole-Genome Sequence of a blaOXA-48-Harboring Raoultella ornithinolytica Clinical Isolate from Lebanon.
abstract: We analyzed the whole-genome sequence of ablaOXA-48-harboringRaoultella ornithinolyticaclinical isolate from a patient in Lebanon. The size of theRaoultella ornithinolyticaCMUL058 genome was 5,622,862 bp, with a G+C content of 55.7%. We deciphered all the molecular mechanisms of antibiotic resistance, and we compared our genome to other availableR. ornithinolyticagenomes in GenBank. The resistome consisted of 9 antibiotic resistance genes, including a plasmidicblaOXA-48gene whose genetic organization is also described.
authors.affiliation: Laboratoire Microbiologie Santé et Environnement, Centre AZM pour la Recherche en Biotechnologie et ses Applications, Ecole Doctorale de Sciences et de Technologie, Université Libanaise, Tripoli, Lebanon Aix-Marseille Université, URMITE UM 63, CNRS 7278, IRD 198, INSERM U1905, Facultés de Médecine et de Pharmacie, Marseille, France.
authors.forename: Charbel
authors.initials: C
authors.lastname: Al-Bayssari
authors.affiliation: Aix-Marseille Université, URMITE UM 63, CNRS 7278, IRD 198, INSERM U1905, Facultés de Médecine et de Pharmacie, Marseille, France.
authors.forename: Abiola Olumuyiwa
authors.identifier: http://orcid.org/0000-0003-2005-5706
authors.initials: AO
authors.lastname: Olaitan
authors.affiliation: Aix-Marseille Université, URMITE UM 63, CNRS 7278, IRD 198, INSERM U1905, Facultés de Médecine et de Pharmacie, Marseille, France.
authors.forename: Thongpan
authors.initials: T
authors.lastname: Leangapichart
authors.affiliation: Aix-Marseille Université, URMITE UM 63, CNRS 7278, IRD 198, INSERM U1905, Facultés de Médecine et de Pharmacie, Marseille, France.
authors.forename: Liliane
authors.initials: L
authors.lastname: Okdah
authors.affiliation: Laboratoire Microbiologie Santé et Environnement, Centre AZM pour la Recherche en Biotechnologie et ses Applications, Ecole Doctorale de Sciences et de Technologie, Université Libanaise, Tripoli, Lebanon.
authors.forename: Fouad
authors.initials: F
authors.lastname: Dabboussi
authors.affiliation: Laboratoire Microbiologie Santé et Environnement, Centre AZM pour la Recherche en Biotechnologie et ses Applications, Ecole Doctorale de Sciences et de Technologie, Université Libanaise, Tripoli, Lebanon.
authors.forename: Monzer
authors.initials: M
authors.lastname: Hamze
authors.affiliation: Aix-Marseille Université, URMITE UM 63, CNRS 7278, IRD 198, INSERM U1905, Facultés de Médecine et de Pharmacie, Marseille, France Jean-marc.rolain@univ-amu.fr.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Rolain
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001482:Base Composition; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D015870:Gene Expression; D059646:Genome Size; D016680:Genome, Bacterial; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007861:Lebanon; D008297:Male; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases
references.citation: Int J Syst Evol Microbiol. 2001 May;51(Pt 3):925-32
references.pmid: 11411716
references.citation: Int J Infect Dis. 2015 May;34:8-13
references.pmid: 25743762
references.citation: J Antimicrob Chemother. 2007 Feb;59(2):321-2
references.pmid: 17185300
references.citation: Nucleic Acids Res. 2007;35(9):3100-8
references.pmid: 17452365
references.citation: BMC Genomics. 2008;9:75
references.pmid: 18261238
references.citation: J Clin Microbiol. 2009 Mar;47(3):868-9
references.pmid: 19144809
references.citation: Bioinformatics. 2009 Aug 15;25(16):2071-3
references.pmid: 19515959
references.citation: Antimicrob Agents Chemother. 2010 Mar;54(3):1369-73
references.pmid: 20086157
references.citation: Pediatr Infect Dis J. 2010 May;29(5):477-8
references.pmid: 20072080
references.citation: Nucleic Acids Res. 2011 Jul;39(Web Server issue):W347-52
references.pmid: 21672955
references.citation: Antimicrob Agents Chemother. 2011 Dec;55(12):5952-4
references.pmid: 21930874
references.citation: Emerg Infect Dis. 2012 Sep;18(9):1503-7
references.pmid: 22932472
references.citation: J Antimicrob Chemother. 2012 Dec;67(12):2860-4
references.pmid: 22855858
references.citation: Intern Med. 2012;51(22):3193-5
references.pmid: 23154732
references.citation: Antimicrob Agents Chemother. 2013 Feb;57(2):1092-3
references.pmid: 23165470
references.citation: Antimicrob Agents Chemother. 2014;58(1):212-20
references.pmid: 24145532
references.citation: J Infect Chemother. 2014 Sep;20(9):589-91
references.pmid: 25012469
references.citation: Antimicrob Agents Chemother. 2015 Jan;59(1):745-6
references.pmid: 25348536
references.citation: PLoS One. 2014;9(12):e116421
references.pmid: 25549365
references.citation: Infection. 2015 Feb;43(1):59-64
references.pmid: 25367410
references.citation: PLoS One. 2015;10(3):e0121668
references.pmid: 25794144
references.citation: Int J Antimicrob Agents. 2006 Apr;27(4):351-3
references.pmid: 16564159