title: A new furanosteroid from Talaromyces sp. lgt-4, a fungal endophyte isolated from Tripterygium wilfordii.
abstract: Wortmannolol (1), a new furanosteroid, along with five known compounds, wortmannolone (2), ergosterol (3), p-hydroxyphenyl ethanol (4), trans-6-dodecene (5), (2Z, 4E) -5-(8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo [3.2.1] octan-8-yl) -3-methylpenta-2,4-dienoic acid (6) were isolated from a fungal endophyte Talaromyces sp. lgt-4. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. Compound 1 show weak monoamine oxidase inhibitory activity.
authors.affiliation: a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.|b The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.
authors.forename: Kang-Kang
authors.initials: KK
authors.lastname: Zhi
authors.affiliation: a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.
authors.forename: Zhong-Duo
authors.initials: ZD
authors.lastname: Yang
authors.affiliation: c Department of Chemistry , Lanzhou University , Lanzhou , P.R. China.
authors.forename: Shuang-Yan
authors.initials: SY
authors.lastname: Zhou
authors.affiliation: c Department of Chemistry , Lanzhou University , Lanzhou , P.R. China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Yao
authors.affiliation: d School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Shenzhen , P.R. China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Li
authors.affiliation: a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000473:Alkanes / Q000302:isolation & purification / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D060026:Endophytes / Q000737:chemistry; D004875:Ergosterol / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D013261:Sterols / Q000302:isolation & purification / Q000494:pharmacology; D032901:Talaromyces / Q000737:chemistry*; D029757:Tripterygium / Q000382:microbiology
chemical_list: D000473:Alkanes; D008996:Monoamine Oxidase Inhibitors; D013261:Sterols; C000619171:wortmannolol; C011867:4-hydroxyphenylethanol; D010626:Phenylethyl Alcohol; D004875:Ergosterol
keywords: Furanosteroid; Talaromyces; Tripterygium wilfordii; endophyte