title: Establishing Age-Adjusted Reference Ranges for Iris-Related Parameters in Open Angle Eyes with Anterior Segment Optical Coherence Tomography.
abstract: Define criteria for iris-related parameters in an adult open angle population as measured with swept source Fourier domain anterior segment optical coherence tomography (ASOCT).
  
  
  
  Ninety-eight eyes of 98 participants with open angles were included and stratified into 5 age groups (18-35, 36-45, 46-55, 56-65, and 66-79 years). ASOCT scans with 3D mode angle analysis were taken with the CASIA SS-1000 (Tomey Corporation, Nagoya, Japan) and analyzed using the Anterior Chamber Analysis and Interpretation software. Anterior iris surface length (AISL), length of scleral spur landmark (SSL) to pupillary margin (SSL-to-PM), iris contour ratio (ICR = AISL/SSL-to-PM), pupil radius, radius of iris centroid (RICe), and iris volume were measured. Outcome variables were summarized for all eyes and age groups, and mean values among age groups were compared using one-way analysis of variance. Stepwise regression analysis was used to investigate demographic and ocular characteristic factors that affected each iris-related parameter.
  
  
  
  Mean (±SD) values were 2.24 mm (±0.46), 4.06 mm (±0.27), 3.65 mm (±0.48), 4.16 mm (±0.47), 1.14 (±0.04), 1.51 mm2 (±0.23), and 38.42 μL (±4.91) for pupillary radius, RICe, SSL-to-PM, AISL, ICR, iris cross-sectional area, and iris volume, respectively. Both pupillary radius (P = 0.002) and RICe (P = 0.027) decreased with age, while SSL-to-PM (P = 0.002) and AISL increased with age (P = 0.001). ICR (P = 0.54) and iris volume (P = 0.49) were not affected by age.
  
  
  
  This study establishes reference values for iris-related parameters in an adult open angle population, which will be useful for future studies examining the role of iris changes in pathologic states.
authors.affiliation: Ruiz Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston (UTHealth) McGovern Medical School, Houston, Texas, United States of America.|Robert Cizik Eye Clinic, Houston, Texas, United States of America.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Peterson
authors.affiliation: Ruiz Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston (UTHealth) McGovern Medical School, Houston, Texas, United States of America.|Robert Cizik Eye Clinic, Houston, Texas, United States of America.
authors.forename: Lauren S
authors.initials: LS
authors.lastname: Blieden
authors.affiliation: Ruiz Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston (UTHealth) McGovern Medical School, Houston, Texas, United States of America.
authors.forename: Alice Z
authors.initials: AZ
authors.lastname: Chuang
authors.affiliation: Robert Cizik Eye Clinic, Houston, Texas, United States of America.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Baker
authors.affiliation: Robert Cizik Eye Clinic, Houston, Texas, United States of America.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Rigi
authors.affiliation: Ruiz Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston (UTHealth) McGovern Medical School, Houston, Texas, United States of America.|Robert Cizik Eye Clinic, Houston, Texas, United States of America.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Feldman
authors.affiliation: Ruiz Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston (UTHealth) McGovern Medical School, Houston, Texas, United States of America.|Robert Cizik Eye Clinic, Houston, Texas, United States of America.
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Bell
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000869:Anterior Eye Segment / Q000473:pathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007498:Iris / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000473:pathology*; D012016:Reference Values; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult
references.citation: J Ophthalmol. 2015;2015:581719
references.pmid: 26351573
references.citation: J Ophthalmol. 2012;2012:487309
references.pmid: 23209880
references.citation: J Glaucoma. 2015 Feb;24(2):144-8
references.pmid: 25186223
references.citation: Graefes Arch Clin Exp Ophthalmol. 2014 Jul;252(7):1127-32
references.pmid: 24781879
references.citation: Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4796-801
references.pmid: 26218907
references.citation: Am J Ophthalmol. 2015 Sep;160(3):506-515.e1
references.pmid: 26093287
references.citation: Invest Ophthalmol Vis Sci. 2015 May;56(5):2842-7
references.pmid: 25829412
references.citation: Invest Ophthalmol Vis Sci. 2013 Nov;54(12):7717-23
references.pmid: 24168992
references.citation: Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5681-90
references.pmid: 26313303
references.citation: Trans Ophthalmol Soc U K. 1971;91:709-39
references.pmid: 5291556
references.citation: Invest Ophthalmol Vis Sci. 1994 Mar;35(3):1132-7
references.pmid: 8125724
references.citation: Invest Ophthalmol Vis Sci. 2013 Jan;54(1):708-13
references.pmid: 23299474
references.citation: J Clin Diagn Res. 2015 Jul;9(7):CC12-5
references.pmid: 26393122
references.citation: J Ophthalmol. 2014;2014:590978
references.pmid: 25210623
references.citation: Trans Am Ophthalmol Soc. 2007;105:99-108; discussion 108-10
references.pmid: 18427599
references.citation: J Glaucoma. 2009 Mar;18(3):173-9
references.pmid: 19295366
references.citation: Arch Ophthalmol. 2004 Apr;122(4):532-8
references.pmid: 15078671
references.citation: Arch Ophthalmol. 2004 Apr;122(4):477-85
references.pmid: 15078664
references.citation: Trans Am Ophthalmol Soc. 1995;93:337-47; discussion 347-51
references.pmid: 8719685
references.citation: Laryngoscope. 2016 Feb;126(2):460-3
references.pmid: 26227880
references.citation: Invest Ophthalmol Vis Sci. 2014 Mar;55(3):1672-83
references.pmid: 24557354
references.citation: Ophthalmology. 2010 Jan;117(1):3-10
references.pmid: 19923002
references.citation: Invest Ophthalmol Vis Sci. 2014 Jul;55(7):4405-12
references.pmid: 24764064