title: Analysis of risk factors for perifocal oedema after endovascular embolization of unruptured intracranial arterial aneurysms.
abstract: BACKGROUND
  Endovascular embolization is a treatment of choice for the management of unruptured intracranial aneurysms, but sometimes is complicated with perianeurysmal oedema. The aim of our study was to establish incidence and outcomes of perianeurysmal oedema after endovascular coiling of unruptured intracranial aneurysms, and to reveal possible risk factors for development of this potentially serious complication.
  
  
  METHODS
  In total 119 adult patients with endovascular embolization of unruptured intracranial aneurysm (performed at Department for Interventional Neuroradiology, Clinical Center, Kragujevac, Serbia) were included in our study. The embolizations were made by electrolite-detachable platinum coils: pure platinum, hydrophilic and combination of platinum and hydrophilic coils. Primary outcome variable was perianeurysmal oedema visualized by magnetic resonance imaging (MRI) 7, 30 and 90 days after the embolization.
  
  
  RESULTS
  The perianurysmal oedema appeared in 47.6% of patients treated with hydrophilic coils, in 21.6% of patients treated with platinum coils, and in 53.8% of those treated with mixed type of the coils. The multivariate logistic regression showed that variables associated with occurrence of perianeurysmal oedema are volume of the aneurysm, hypertension, diabetes and smoking habit. Hypertension is the most important independent predictor of the perianeurysmal oedema, followed by smoking and diabetes.
  
  
  CONCLUSIONS
  The results of our study suggest that older patients with larger unruptured intracranial aneurysms, who suffer from diabetes mellitus and hypertension, and have the smoking habit, are under much higher risk of having perianeurysmal oedema after endovascular coiling.
authors.affiliation: Department for Interventional Neuroradiology, Clinical Center, Kragujevac, University of Kragujevac, Serbia.
authors.forename: Snezana
authors.initials: S
authors.lastname: Lukic
authors.affiliation: Department for Clinical Pharmacology, Clinical Center, Kragujevac, Serbia.
authors.forename: Slobodan
authors.initials: S
authors.lastname: Jankovic
authors.affiliation: Clinical Radiology Institute, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Katarina Surlan
authors.initials: KS
authors.lastname: Popovic
authors.affiliation: Faculty of Natural Sciences and Mathematics, University of Kragujevac, Serbia.
authors.forename: Dragic
authors.initials: D
authors.lastname: Bankovic
authors.affiliation: Clinical Radiology Institute, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Peter
authors.initials: P
authors.lastname: Popovic
authors.affiliation: Department for Interventional Neuroradiology, Clinical Center, Kragujevac, University of Kragujevac, Serbia.
authors.forename: Milan
authors.initials: M
authors.lastname: Mijailovic
keywords: endovascular embolization; hypertension; intracranial aneurysms; perianeurysmal oedema
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