title: Plasma concentrations of amino acid and nicotinamide metabolites in rheumatoid arthritis--potential biomarkers of disease activity and drug treatment.
abstract: This study aimed to evaluate changes in plasma amino acid and nicotinamide metabolites concentrations in rheumatoid arthritis (RA) in a search for potential biomarkers of the disease activity and the effect treatment. Analysis of plasma metabolite patterns with liquid chromatography/mass spectrometry revealed specific changes in RA as well as correlations with clinical parameters. Combined concentration parameter calculated as [aspartic acid] + [threonine] + [tryptophan] - [histidine] - [phenylalanine] offered the strongest correlation (p < 0.001) with pain joint count, swollen joint count and DAS 28. Such analysis of amino acid and related metabolite pattern offers potential for diagnosis as well as for monitoring disease progression and therapy in RA.
authors.affiliation: a Department of Internal Medicine , Connective Tissue Diseases and Geriatrics, Medical University of Gdansk , Gdansk , Poland and.
authors.forename: Zaneta
authors.initials: Z
authors.lastname: Smolenska
authors.affiliation: b Department of Biochemistry , Medical University of Gdansk , Gdansk , Poland.
authors.forename: Ryszard T
authors.initials: RT
authors.lastname: Smolenski
authors.affiliation: a Department of Internal Medicine , Connective Tissue Diseases and Geriatrics, Medical University of Gdansk , Gdansk , Poland and.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Zdrojewski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000596:Amino Acids / Q000097:blood* / Q000302:isolation & purification; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood*; D002853:Chromatography, Liquid; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D055432:Metabolomics; D008875:Middle Aged; D009536:Niacinamide / Q000097:blood*
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D009536:Niacinamide
keywords: Amino acids; metabolomics; nicotinamide metabolites; rheumatoid arthritis