title: Circulating tumor cells in breast cancer.
abstract: Over the past decade, technically reliable circulating tumor cell (CTC) detection methods allowed the collection of large datasets of CTC counts in cancer patients. These data can be used either as a dynamic prognostic biomarker or as tumor material for "liquid biopsy". Breast cancer appears to be the cancer type in which CTC have been the most extensively studied so far, with level-of-evidence-1 studies supporting the clinical validity of CTC count in both early and metastatic stage. This review summarizes and discusses the clinical results obtained in breast cancer patients, the issues faced by the molecular characterization of CTC and the biological findings about cancer biology and metastasis that were obtained from CTC.
authors.affiliation: Institut Curie, PSL Research University, SiRIC, Laboratory of Circulating Tumor Biomarkers, Paris, France; Institut Curie, PSL Research University, Department of Medical Oncology, Paris, France.
authors.forename: Francois-Clement
authors.initials: FC
authors.lastname: Bidard
authors.affiliation: Institut Curie, PSL Research University, SiRIC, Laboratory of Circulating Tumor Biomarkers, Paris, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Proudhon
authors.affiliation: Institut Curie, PSL Research University, SiRIC, Laboratory of Circulating Tumor Biomarkers, Paris, France; Institut Curie, PSL Research University, Department of Medical Oncology, Paris, France; Université Paris Descartes, Paris, France. Electronic address: jean-yves.pierga@curie.fr.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Pierga
mesh_terms: D000818:Animals; D001706:Biopsy / Q000379:methods; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000473:pathology; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D011379:Prognosis
keywords: Breast cancer; Circulating tumor cells; Metastatic process; Prognostic markers
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