title: Synthesis of polysubstituted 1,2-dihydroquinolines and indoles via cascade reactions of arylamines and propargylic alcohols catalyzed by FeCl3·6H2O.
abstract: An efficient, environmentally friendly and high-yielding route from inexpensive starting materials to 1,2-dihydroquinolines has been developed. This procedure proceeded via a cascade Friedel-Crafts-type reaction and 6-endo-trig hydroamination under the catalysis of FeCl3·6H2O, involving the formation of two new σ (C-C and C-N) bonds in a single operation for the construction of a 1,2-dihydroquinoline skeleton in good to excellent yields.
authors.affiliation: Department of Chemistry, Wannan Medical College, Wuhu, Anhui 241002, China. wsychem@163.com.
authors.forename: Min
authors.initials: M
authors.lastname: Shao
authors.affiliation: Department of Chemistry, Wannan Medical College, Wuhu, Anhui 241002, China. wsychem@163.com.
authors.forename: Yunjun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Chemistry, Wannan Medical College, Wuhu, Anhui 241002, China. wsychem@163.com.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Department of Chemistry, Wannan Medical College, Wuhu, Anhui 241002, China. wsychem@163.com.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Gu
authors.affiliation: Department of Chemistry, Wannan Medical College, Wuhu, Anhui 241002, China. wsychem@163.com and Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, Institute of Organic Chemistry, School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China.
authors.forename: Shaoyin
authors.initials: S
authors.lastname: Wang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D000588:Amines; D002712:Chlorides; D005290:Ferric Compounds; D020005:Propanols; D011804:Quinolines; C028255:propargyl alcohol; C024555:ferric chloride