title: Fat Matters: Understanding the Role of Adipose Tissue in Health in HIV Infection.
abstract: More than one-third of adults in the USA are obese and obesity-related disease accounts for some of the leading causes of preventable death. Mid-life obesity may be a strong predictor of physical function impairment later in life regardless of body mass index (BMI) in older age, highlighting the benefits of obesity prevention on health throughout the lifespan. Adipose tissue disturbances including lipodystrophy and obesity are prevalent in the setting of treated and untreated HIV infection. This article will review current knowledge on fat disturbances in HIV-infected persons, including therapeutic options and future directions.
authors.affiliation: University of Colorado-Anschutz Medical Center, 12700 E 19th Ave, Mailstop B168, Aurora, CO, USA. kristine.erlandson@ucdenver.edu.
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Erlandson
authors.affiliation: University of California, Los Angeles, 11075 Santa Monica Blvd., Ste. 100, Los Angeles, CA, USA. jlake@mednet.ucla.edu.
authors.forename: Jordan E
authors.initials: JE
authors.lastname: Lake
mesh_terms: D017667:Adipocytes / Q000473:pathology*; D000273:Adipose Tissue / Q000166:cytology / Q000503:physiopathology*; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D050218:Body Fat Distribution; D015658:HIV Infections / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D006801:Humans; D008060:Lipodystrophy / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D014481:United States / Q000453:epidemiology
chemical_list: D019380:Anti-HIV Agents
keywords: Adipose tissue; Antiretroviral therapy; BMI; HIV; HIV infection; HIV/AIDS; Inflammation; Lipodystrophy; Obesity; Obesity and HIV; Review
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