title: A retrospective review of safety using a nursing driven protocol for autonomic dysreflexia in patients with spinal cord injuries.
abstract: Autonomic dysreflexia is a potentially life-threatening condition which afflicts a significant proportion of individuals with spinal cord injuries (SCI). To date, the safety and efficacy of several commonly used interventions for this condition have not been studied.
  
  
  
  A retrospective chart review of the safety of a previously implemented nursing driven inpatient autonomic dysreflexia protocol.
  
  
  
  Seventy-eight male patients with SCI who experienced autonomic dysreflexia while inpatient at our Veterans Affairs SCI unit over a 3-1/2-year period were included. The safety of a nursing driven protocol utilizing conservative measures, nitroglycerin paste, and oral hydralazine was evaluated.
  
  
  
  Occurrence of adverse events and relative hypotensive events during all episodes treated with the protocol, and efficacy of attaining target blood pressure for all episodes with protocol adherence and for initial episode experienced by each patient.
  
  
  
  Four hundred forty-five episodes of autonomic dysreflexia were recorded in the study period, with 92% adherence to the protocol. When the protocol was followed, target blood pressure was achieved for 97.6% of all episodes. Twenty-three total adverse events occurred (5.2% of all episodes). All adverse events were due to hypotension and only 0.9% required interventions beyond clinical monitoring. Of each patient's initial autonomic dysreflexia episode, 97.3% resolved using the protocol without need for further escalation of care.
  
  
  
  This inpatient nursing driven-protocol for treating autonomic dysreflexia utilizing conservative measures, nitroglycerin paste and oral hydralazine achieved target blood pressure with a high success rate and a low incidence of adverse events.
authors.affiliation: a Department of Rehabilitation Medicine , University of Washington , Seattle , WA , USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Solinsky
authors.affiliation: a Department of Rehabilitation Medicine , University of Washington , Seattle , WA , USA.|b Spinal Cord Injury Service, Veterans Affairs Puget Sound Health Care System , Seattle , WA , USA.
authors.forename: Jelena N
authors.initials: JN
authors.lastname: Svircev
authors.affiliation: c Northwest Physical Medicine , Seattle , WA , USA.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: James
authors.affiliation: a Department of Rehabilitation Medicine , University of Washington , Seattle , WA , USA.|b Spinal Cord Injury Service, Veterans Affairs Puget Sound Health Care System , Seattle , WA , USA.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Burns
authors.affiliation: a Department of Rehabilitation Medicine , University of Washington , Seattle , WA , USA.|d Harborview Medical Center , Seattle , WA , USA.
authors.forename: Aaron E
authors.initials: AE
authors.lastname: Bunnell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020211:Autonomic Dysreflexia / Q000188:drug therapy* / Q000209:etiology; D019983:Guideline Adherence; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D061214:Patient Safety; D017410:Practice Guidelines as Topic; D013119:Spinal Cord Injuries / Q000150:complications* / Q000628:therapy; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D006830:Hydralazine; D005996:Nitroglycerin
keywords: Autonomic dysreflexia; Hydralazine; Nitroglycerin; Spinal cord injuries
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