title: Cell-Type and State-Dependent Synchronization among Rodent Somatosensory, Visual, Perirhinal Cortex, and Hippocampus CA1.
abstract: Beta and gamma rhythms have been hypothesized to be involved in global and local coordination of neuronal activity, respectively. Here, we investigated how cells in rodent area S1BF are entrained by rhythmic fluctuations at various frequencies within the local area and in connected areas, and how this depends on behavioral state and cell type. We performed simultaneous extracellular field and unit recordings in four connected areas of the freely moving rat (S1BF, V1M, perirhinal cortex, CA1). S1BF spiking activity was strongly entrained by both beta and gamma S1BF oscillations, which were associated with deactivations and activations, respectively. We identified multiple classes of fast spiking and excitatory cells in S1BF, which showed prominent differences in rhythmic entrainment and in the extent to which phase locking was modulated by behavioral state. Using an additional dataset acquired by whole-cell recordings in head-fixed mice, these cell classes could be compared with identified phenotypes showing gamma rhythmicity in their membrane potential. We next examined how S1BF cells were entrained by rhythmic fluctuations in connected brain areas. Gamma-synchronization was detected in all four areas, however we did not detect significant gamma coherence among these areas. Instead, we only found long-range coherence in the theta-beta range among these areas. In contrast to local S1BF synchronization, we found long-range S1BF-spike to CA1-LFP synchronization to be homogeneous across inhibitory and excitatory cell types. These findings suggest distinct, cell-type contributions of low and high-frequency synchronization to intra- and inter-areal neuronal interactions.
authors.affiliation: Cognitive and Systems Neuroscience Group, SILS Center for Neuroscience, University of AmsterdamAmsterdam, Netherlands; Research Priority Program Brain and Cognition, University of AmsterdamAmsterdam, Netherlands; Department of Neurobiology, Yale UniversityNew Haven, CT, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Vinck
authors.affiliation: Cognitive and Systems Neuroscience Group, SILS Center for Neuroscience, University of AmsterdamAmsterdam, Netherlands; Research Priority Program Brain and Cognition, University of AmsterdamAmsterdam, Netherlands.
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bos
authors.affiliation: Cognitive and Systems Neuroscience Group, SILS Center for Neuroscience, University of AmsterdamAmsterdam, Netherlands; Research Priority Program Brain and Cognition, University of AmsterdamAmsterdam, Netherlands.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Van Mourik-Donga
authors.affiliation: Cognitive and Systems Neuroscience Group, SILS Center for Neuroscience, University of AmsterdamAmsterdam, Netherlands; Research Priority Program Brain and Cognition, University of AmsterdamAmsterdam, Netherlands.
authors.forename: Krista T
authors.initials: KT
authors.lastname: Oplaat
authors.affiliation: Cognitive and Systems Neuroscience Group, SILS Center for Neuroscience, University of AmsterdamAmsterdam, Netherlands; Research Priority Program Brain and Cognition, University of AmsterdamAmsterdam, Netherlands.
authors.forename: Gerbrand A
authors.initials: GA
authors.lastname: Klein
authors.affiliation: Cognitive and Systems Neuroscience Group, SILS Center for Neuroscience, University of AmsterdamAmsterdam, Netherlands; Research Priority Program Brain and Cognition, University of AmsterdamAmsterdam, Netherlands.
authors.forename: Jadin C
authors.initials: JC
authors.lastname: Jackson
authors.affiliation: Cognitive and Systems Neuroscience Group, SILS Center for Neuroscience, University of AmsterdamAmsterdam, Netherlands; Research Priority Program Brain and Cognition, University of AmsterdamAmsterdam, Netherlands; Team Waking, Lyon Neuroscience Research Center, Institut National de la Santé et de La Recherche Médicale U1028 - Centre National de la Recherche Scientifique UMR 5292Lyon, France.
authors.forename: Luc J
authors.initials: LJ
authors.lastname: Gentet
authors.affiliation: Cognitive and Systems Neuroscience Group, SILS Center for Neuroscience, University of AmsterdamAmsterdam, Netherlands; Research Priority Program Brain and Cognition, University of AmsterdamAmsterdam, Netherlands.
authors.forename: Cyriel M A
authors.initials: CM
authors.lastname: Pennartz
keywords: interneurons; long-range synchronization; oscillations; rhythmicity; synchronization
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