title: Circadian system - A novel diagnostic and therapeutic target in Parkinson's disease?
abstract: The circadian system regulates biological rhythmicity in the human body. The role of the circadian system in neurological disorders is a theme that is attracting an increasing amount of interest from the scientific community. This has arisen, in part, from emerging evidence that disorders such as Parkinson's disease (PD) are multifactorial with many features exhibiting diurnal fluctuations, thereby suggestive of circadian involvement. Although the importance of fluctuating motor and nonmotor manifestations in PD have been well acknowledged, the role of the circadian system has received little attention until recently. It is proposed that intervening with circadian function provides a novel research avenue down which new strategies for improving symptomatic treatment and slowing of the progressive degenerative process can be approached to lessen the burden of PD. In this article we review the literature describing existing circadian research in PD and its experimental models.
authors.affiliation: Movement Disorders Unit, Massachusetts General Hospital, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Videnovic
authors.affiliation: The Bronowski Institute of Behavioural Neuroscience, Kyneton, Victoria, Australia.
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Willis
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*
keywords: Parkinson's; chronobiology; circadian; clock genes; sleep
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