title: CD47: a potential immunotherapy target for eliminating cancer cells.
abstract: The relationship between the immune system and cancer growth and aggravation has been discussed over a century. A number of molecules have been shown to participate in this process. CD47, a normal universally expressed member of the immunoglobulin superfamily, plays multiple functions in immune system. Researches demonstrated that CD47 was also highly expressed on the surface of tumor cells as well as cancer stem cells (CSCs). Whether the highly expressed CD47 was associated with tumor growth, metastasis, recurrence, or drug resistance has become the hotspot. Besides the roles of CD47 in tumor immunoregulation, the monoclonal antibodies targeting CD47 used in acute myelogenous leukemia (AML) and bladder CSCs were reported, which shed new light on tumor treatment. CSCs have been recognized as the root of tumor drug resistance and recurrence. Whether CD47 on CSCs could serve as a potential target for future anti-cancer treatment forms the focus of our review. Here we highlight the potential roles of CD47 in immune system, and discuss the promising therapeutic application of anti-CD47 antibodies for eliminating tumor cells.
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Anshanxi Road, Nankai District, Tianjin, 300193, China. kongfanming08@163.com.
authors.forename: F
authors.initials: F
authors.lastname: Kong
authors.affiliation: Department of Pediatrics, Tianjin Medical University General Hospital, Anshan Road, Tianjin, 300052, China.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Anshanxi Road, Nankai District, Tianjin, 300193, China.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Anshanxi Road, Nankai District, Tianjin, 300193, China.
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Anshanxi Road, Nankai District, Tianjin, 300193, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Tianjin Medical University General Hospital, Anshan Road, Tianjin, 300052, China.
authors.forename: R
authors.initials: R
authors.lastname: Zheng
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Anshanxi Road, Nankai District, Tianjin, 300193, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Anshanxi Road, Nankai District, Tianjin, 300193, China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Anshanxi Road, Nankai District, Tianjin, 300193, China.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Tianjin Medical University General Hospital, Anshan Road, Tianjin, 300052, China.
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Anshanxi Road, Nankai District, Tianjin, 300193, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Jia
mesh_terms: D000818:Animals; D051928:CD47 Antigen; D006801:Humans; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000276:immunology*
chemical_list: D051928:CD47 Antigen
keywords: CD47; Cancer stem cells; Immune system; Tumor immune regulation
references.citation: Nat Rev Cancer. 2002 Aug;2(8):584-93
references.pmid: 12154351
references.citation: J Immunol. 1997 Jan 15;158(2):677-84
references.pmid: 8992983
references.citation: Trends Cell Biol. 2005 Sep;15(9):494-501
references.pmid: 16084092
references.citation: J Immunol. 2007 May 1;178(9):5930-9
references.pmid: 17442977
references.citation: Int Immunol. 1999 May;11(5):707-18
references.pmid: 10330276
references.citation: Curr Opin Immunol. 2002 Aug;14(4):420-31
references.pmid: 12088675
references.citation: Trends Cell Biol. 2001 Mar;11(3):130-5
references.pmid: 11306274
references.citation: J Exp Med. 1997 Jan 6;185(1):1-11
references.pmid: 8996237
references.citation: Nat Immunol. 2007 Dec;8(12):1287-9
references.pmid: 18026079
references.citation: Gastroenterology. 2007 Jun;132(7):2542-56
references.pmid: 17570225
references.citation: J Mol Biol. 2008 Jan 18;375(3):650-60
references.pmid: 18045614
references.citation: Curr Opin Immunol. 2012 Apr;24(2):225-32
references.pmid: 22310103
references.citation: J Immunol. 2005 Feb 15;174(4):2004-11
references.pmid: 15699129
references.citation: Cell. 2009 Jul 23;138(2):271-85
references.pmid: 19632178
references.citation: J Immunol. 2005 Jan 15;174(2):654-61
references.pmid: 15634883
references.citation: J Cell Biol. 1995 Aug;130(3):503-6
references.pmid: 7542656
references.citation: Mol Cell Biol. 1998 Jul;18(7):3838-50
references.pmid: 9632768
references.citation: Mol Cancer Ther. 2007 Oct;6(10):2609-17
references.pmid: 17938257
references.citation: J Immunol. 2000 Feb 15;164(4):2193-9
references.pmid: 10657674
references.citation: Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16281-6
references.pmid: 19805294
references.citation: J Mammary Gland Biol Neoplasia. 2005 Apr;10(2):169-80
references.pmid: 16025223
references.citation: N Engl J Med. 2004 Apr 15;350(16):1655-64
references.pmid: 15084698
references.citation: J Immunol. 1999 Jun 15;162(12):7031-40
references.pmid: 10358145
references.citation: Cell Death Differ. 2008 Mar;15(3):504-14
references.pmid: 18049477
references.citation: J Immunol. 1999 Oct 1;163(7):3621-8
references.pmid: 10490955
references.citation: Cell. 2005 Oct 21;123(2):321-34
references.pmid: 16239148
references.citation: Nature. 2007 Jan 4;445(7123):106-10
references.pmid: 17122772
references.citation: Cell. 2009 Jul 23;138(2):286-99
references.pmid: 19632179
references.citation: Cancer Res. 2009 Apr 1;69(7):3196-204
references.pmid: 19276363
references.citation: J Exp Med. 2005 Aug 1;202(3):337-40
references.pmid: 16061722
references.citation: Science. 2011 Mar 25;331(6024):1565-70
references.pmid: 21436444
references.citation: Cancer Res. 2004 Feb 1;64(3):1026-36
references.pmid: 14871834
references.citation: Stem Cells. 2009 Dec;27(12 ):2875-83
references.pmid: 19816957
references.citation: Cell. 2010 Sep 3;142(5):699-713
references.pmid: 20813259
references.citation: J Cell Biol. 2008 Mar 10;180(5):989-1003
references.pmid: 18332220
references.citation: Science. 2000 Jun 16;288(5473):2051-4
references.pmid: 10856220
references.citation: J Immunol. 2006 May 15;176(10):5772-8
references.pmid: 16670282
references.citation: Annu Rev Immunol. 2003;21:685-711
references.pmid: 12615891
references.citation: Nature. 2011 Jan 20;469(7330):314-22
references.pmid: 21248838
references.citation: J Exp Med. 2003 Oct 20;198(8):1277-83
references.pmid: 14568985
references.citation: Tumour Biol. 2011 Jun;32(3):425-40
references.pmid: 21318290
references.citation: Biochem Biophys Res Commun. 2007 Jan 12;352(2):444-8
references.pmid: 17126807
references.citation: Cancer Res. 2009 Mar 1;69(5):1776-81
references.pmid: 19208848
references.citation: J Immunol. 2003 Dec 1;171(11):5718-26
references.pmid: 14634079
references.citation: J Immunol. 2008 Jun 15;180(12):8073-82
references.pmid: 18523271
references.citation: Nature. 2004 Nov 18;432(7015):396-401
references.pmid: 15549107
references.citation: J Immunol. 2000 Apr 1;164(7):3652-8
references.pmid: 10725722
references.citation: J Immunol. 1997 Dec 1;159(11):5345-54
references.pmid: 9548474
references.citation: EMBO J. 2006 Nov 29;25(23):5560-8
references.pmid: 17093498
references.citation: J Immunol. 2002 Apr 1;168(7):3213-20
references.pmid: 11907074
references.citation: Nat Rev Immunol. 2002 Jan;2(1):46-53
references.pmid: 11905837
references.citation: J Immunol. 2000 Oct 15;165(8):4624-31
references.pmid: 11035105
references.citation: Cancer Res. 2007 Sep 1;67(17):8216-22
references.pmid: 17804735
references.citation: J Assoc Physicians India. 1989 Apr;37(4):253-4
references.pmid: 2613617
references.citation: J Exp Med. 2001 Apr 2;193(7):855-62
references.pmid: 11283158
references.citation: J Immunol. 2000 Mar 15;164(6):2947-54
references.pmid: 10706681
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14016-21
references.pmid: 19666525
references.citation: Cancer Res. 2007 Jul 15;67(14):6796-805
references.pmid: 17638891
references.citation: J Immunol. 2005 Dec 15;175(12):7781-7
references.pmid: 16339510
references.citation: Tumour Biol. 2008;29(1):28-34
references.pmid: 18497546
references.citation: Nature. 1997 Mar 13;386(6621):181-6
references.pmid: 9062191