title: Relationship between Tooth Loss, Functional Dyspepsia and Gastro-Esophageal Reflux Disorder among Isfahani Adults.
abstract: BACKGROUND
  Few studies have assessed the relationship between tooth loss and upper gastro-intestinal (GI) disorders including functional dyspepsia (FD) and gastro-esophageal reflux disease (GERD). This study aimed to investigate the relation between dental status and FD, its components and GERD among a large group of Isfahani adults.
  
  
  METHODS
  In a cross-sectional study from April to May 2010, the dental status of 4109 Isfahani adults was evaluated using a self-administered questionnaire. Participants were categorized into three main groups: those with full dentition, individual who had lost 1-5 teeth and those who had lost >5 teeth. FD, its components and GERD were defined using Rome III criteria. Multivariable logistic regression was used to examine the relationship between dental status and gastrointestinal disorders.
  
  
  RESULTS
  After adjustment for potential confounders, we found no significant association between dental status, FD and GERD. However, individuals who had lost 1-5 teeth and >5 teeth had 34% and 109% greater odds for early satiation, respectively. In addition, individuals who had lost 1-5 teeth were 24% likely to have postprandial fullness and epigastric pain. Stratified analyses by gender also revealed a significant association between dental status and GERD as well as FD in females; such that those who had lost 1-5 teeth had 33% greater chance for GERD and those who had lost >5 teeth were 101% more likely to have FD compared with those with full dentition.
  
  
  CONCLUSIONS
  We found significant positive associations between tooth loss, GERD and FD in women, but not in men. We also found significant relations between tooth loss and components of FD, especially early satiety in the entire population.
authors.affiliation: Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Adibi
authors.affiliation: 1)Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2)Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Ammar Hassanzadeh
authors.initials: AH
authors.lastname: Keshteli
authors.affiliation: Department of Endodontics, School of Dentistry, Boroujerd branch, Islamic Azad University of Medical Sciences, Boroujerd, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Saneei
authors.affiliation: 4)Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 5)Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 6)Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Parvane
authors.initials: P
authors.lastname: Saneei
authors.affiliation: Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Omid
authors.initials: O
authors.lastname: Savabi
authors.affiliation: 4)Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.6)Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.8)Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Esmaillzadeh
mesh_terms: D015746:Abdominal Pain / Q000453:epidemiology; D000328:Adult; D003430:Cross-Sectional Studies; D004415:Dyspepsia / Q000453:epidemiology*; D004435:Eating; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology*; D006306:Health Surveys; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D015995:Prevalence; D012527:Satiation; D012737:Sex Factors; D016388:Tooth Loss / Q000453:epidemiology*