title: [Distribution of both HBsAg and HBsAb negative adults in Mianyang, Sichuan province].
abstract: OBJECTIVE
  To understand the distribution of both HBsAg and HBsAb negative adults in Mianyang, Sichuan province, and provide evidences for the development of adult immunization policy.
  
  
  METHODS
  From June 2013 to April 2014, a total of 200 929 people aged ≥15 years were selected in Mianyang through stratified cluster random sampling to conduct an interview with standard questionnaire. The blood samples were collected from them for the detection of HBsAg and HBsAb with enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Among the people surveyed, 13 903 were HBsAg positive (7.0%), 93 763 were HBsAb positive (46.6%), and 93 122 were both HBsAg and HBsAb negative (46.3%). The negative rate of both HBsAg and HBsAb in females (47.1%) was higher than that in males (45.4%). The negative rate of both HBsAg and HBsAb increased with age. The negative rate of both HBsAg and HBsAb was highest in people aged ≥65 years (50.3%) and lowest in people aged 15-24 years (42.9%). The negative rate of both HBsAg and HBsAb was highest in farmers (51.1%) and lowest in medical workers (24.1%). The negative rate of both HBsAg and HBsAb was highest in the widowed (51.1%) and lowest in the unmarried (41.6%). The negative rate of both HBsAg and HBsAb was lower in people with family history of hepatitis B (36.5%) than in people without family history of hepatitis B (46.6%). The negative rate of both HBsAg and HBsAb in Han ethnic group was lower (46.3%) than that in Qiang ethnic group (53.1%), but higher than that in other ethnic groups (43.9%). The negative rate of both HBsAg and HBsAb was higher in rural area (48.9%) than in urban area (43.0%). The negative rate of both HBsAg and HBsAb was lower in people who had received hepatitis B immunization (43.7%) than in people who had received no hepatitis B immunization (47.3%). The differences were all statistical significant (P<0.01).
  
  
  CONCLUSIONS
  The negative rate of both HBsAg and HBsAb was 46.3% in people aged ≥15 years in Mianyang. General population are susceptible to hepatitis B virus infection. It is necessary to develop and implement appropriate hepatitis B immunization strategy for local adult population.
authors.affiliation: West China School of Public Health, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Shuwen
authors.initials: S
authors.lastname: Cheng
authors.affiliation: West China School of Public Health, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Xiao
authors.affiliation: West China School of Public Health, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Respiratory and Critical Care Department, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Infectious Disease Center, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Fucheng District Center for Disease Control and Prevention, Mianyang City, Sichuan Province, Mianyang 621051, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Ren
authors.affiliation: Jiangyou County Center for Disease Control and Prevention, Sichuan Province, Jiangyou 621700, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.affiliation: West China School of Public Health, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wen
authors.affiliation: West China School of Public Health, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Zhang
authors.affiliation: West China School of Public Health, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yuan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005006:Ethnicity; D005260:Female; D006282:Health Personnel; D006509:Hepatitis B / Q000453:epidemiology*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006515:Hepatitis B virus; D006801:Humans; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires; D014611:Vaccination / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines