title: Safety of Grass Pollen Sublingual Immunotherapy for Allergic Rhinitis in Concomitant Asthma.
abstract: Seasonal allergic rhinitis (AR) occurs predominantly as a result of grass pollen allergy. Grass pollen sublingual immunotherapy (SLIT) has been proven effective in treating AR1. SLIT is currently licensed for use in AR with concomitant stable mild asthma. There is evidence that SLIT improves asthma control when primarily used to treat AR2. The aim was to assess the safety of SLIT in patients with severe seasonal allergic rhinitis who have co-existing stable mild asthma. The secondary aim was to determine whether asthma control improved post SLIT. There was no deterioration in asthma control after 6-36 months of SLIT. 27/30 (90%) patients' asthma control remained stable or indeed improved (p < 0.021). Of this 15 (50%) patients' asthma improved. There was no statistically significant change in their asthma pharmacotherapy after SLIT (p = 0.059). In conclusion, grass pollen SLIT is safe and can potentially treat dual allergic rhinitis- mild asthmatic patients.
authors.forename: A
authors.initials: A
authors.lastname: Sahadevan
authors.forename: R
authors.initials: R
authors.lastname: Cusack
authors.forename: S J
authors.initials: SJ
authors.lastname: Lane
mesh_terms: D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D000368:Aged; D052179:Antigens, Plant / Q000009:adverse effects*; D001249:Asthma / Q000150:complications*; D002648:Child; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D008875:Middle Aged; D010936:Plant Extracts / Q000009:adverse effects*; D011446:Prospective Studies; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000628:therapy*; D055815:Young Adult
chemical_list: D052179:Antigens, Plant; D010936:Plant Extracts; C451253:grass pollen extract, alum-adsorbed