title: Evaluation of Endothelial and Platelet Derived Microparticles in Patients with Acute Coronary Syndrome.
abstract: BACKGROUND
  Microparticles (MP) are a nuclear fragments of membrane released by the damaged cell during stress. Elevated levels of MP have been found in patients with acute coronary syndrome (ACS) owing to the damage in the endothelium.
  
  
  OBJECTIVE
  To determine if the levels of endothelial and platelet microparticles (EMP & PMP) in patients with ACS influenced the severity of the disease.
  
  
  METHODS
  This was a prospective cohort study performed in 63 ACS patients (ST elevation myocardial infarction- STEMI-28, non ST elevation myocardial infarction -NSTEMI-35). After obtaining consent, blood samples were collected from the patients and processed by flow cytometry.
  
  
  RESULTS
  The NSTEMI group had higher levels of EMP {792.11(327.59-1661.49) vs 300.35 (176.3-550.46), p=0.001} and PMP {218.87(86.65-439.77) vs 114.45(50.34-196.75), p= 0.007} as compared to the STEMI group. However, it was found that the EMP (r=-0.438, p=0.001) and PMP (r= -0.316, p=0.024) negatively correlated with Global Registry of Acute Coronary Events score (GRACE in-hospital score) for the entire cohort.
  
  
  CONCLUSIONS
  The levels of microparticles are elevated in ACS patients and may reflect a protective effect in patients with acute coronary syndrome.
authors.affiliation: Assistant Professor, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .
authors.forename: Melvin
authors.initials: M
authors.lastname: George
authors.affiliation: Assistant Professor, Interdisciplinary School of Indian System of Medicine, SRM University , Tamil Nadu, India .
authors.forename: M R
authors.initials: MR
authors.lastname: Ganesh
authors.affiliation: Clinical Research Associate, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .
authors.forename: Aruna
authors.initials: A
authors.lastname: Sridhar
authors.affiliation: Clinical Research Associate, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .
authors.forename: Amrita
authors.initials: A
authors.lastname: Jena
authors.affiliation: Clinical Research Associate, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .
authors.forename: Muthukumar
authors.initials: M
authors.lastname: Rajaram
authors.affiliation: Professor, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .
authors.forename: Elangovan
authors.initials: E
authors.lastname: Shanmugam
authors.affiliation: HOD and Professor, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .
authors.forename: V E
authors.initials: VE
authors.lastname: Dhandapani
keywords: Endothelial microparticles; GRACE Score; Myocardial infarction; Platelet microparticles
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