title: Triticale allergy in a farmer.
abstract: We present the case of a 29-year-old farmer with hay fever and atopic dermatitis since adolescence who had developed work-related asthma about 5 years earlier. He was sensitized to grass pollen, wheat and rye flour, dust from the floors of the animal facilities (cows and pigs) and grain barn, and a battery of animal feed from his farm. Work-relatedness of his asthma was demonstrated by serial measurements of spirometry and fractional exhaled nitric oxide at work and during a holiday. Immunoblot analyses revealed dominant IgE-binding to grass pollen and triticale (a hybrid of rye and wheat). IgE inhibition experiments demonstrated that sensitization to triticale was not due to cross-reactivity to grass pollen. Testing of specific IgE-antibodies to recombinant wheat allergens showed sensitizations to profilin, peroxidase, and nonspecific lipid transfer proteins type I subfamily 9.1 and 9.7. We conclude that triticale allergy may occur as a distinct allergy in farmers. Am. J. Ind. Med. 59:501-505, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Merget
authors.affiliation: Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Sander
authors.affiliation: Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
authors.forename: Vera
authors.initials: V
authors.lastname: van Kampen
authors.affiliation: Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Raulf
authors.affiliation: Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brüning
mesh_terms: D000328:Adult; D000485:Allergens; D052179:Antigens, Plant / Q000276:immunology; D001249:Asthma / Q000276:immunology; D000067565:Farmers; D006801:Humans; D006967:Hypersensitivity; D008297:Male; D000066889:Triticale / Q000276:immunology*
chemical_list: D000485:Allergens; D052179:Antigens, Plant
keywords: allergy; farmer; grain; occupational; triticale