title: Renal Amyloidosis.
abstract: Amyloidosis is an uncommon group of diseases in which soluble proteins aggregate and deposit extracellularly in tissue as insoluble fibrils, leading to tissue destruction and progressive organ dysfunction. More than 25 proteins have been identified as amyloid precursor proteins. Amyloid fibrils have a characteristic appearance on ultrastructural examination and generate anomalous colors under polarized light. Amyloidosis can be systemic or localized. The kidney is a prime site for amyloid deposition. Immunofluorescence, immunoperoxidase, and more recently laser microdissection and mass spectrometry are important tools used in the typing of renal amyloidosis.
authors.affiliation: Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital-Dammam, Omar Bin Thabit Street, Dammam, Kingdom of Saudi Arabia.
authors.forename: Nasreen
authors.initials: N
authors.lastname: Mohamed
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: nasr.samih@mayo.edu.
authors.forename: Samih H
authors.initials: SH
authors.lastname: Nasr
keywords: AA amyloidosis; AL amyloidosis; Amyloid types; Amyloidosis; Laser microdissection and mass spectrometry; Renal biopsy