title: A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria.
abstract: Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) have been used to diagnose new-onset diabetes mellitus (DM) in order to simplify the diagnostic tests compared with the 2-hour oral glucose tolerance test (OGTT; 2-hPG). We aimed to identify optimal cut-off points of high sensitive C-reactive protein (hs-CRP) in new-onset DM people based on FPG, 2-hPG, or HbA1c methods. Data derived from recent population-based survey in Turkey (TURDEP-II). The study included 26,499 adult people (63% women, response rate 85%). The mean serum concentration of hs-CRP in women was higher than in men (p < 0.001). The people with new-onset DM based on HbA1c had higher mean hs-CRP level than FPG based and 2-hPG based DM cases. In HbA1c, 2-hPG, and FPG based new-onset DM people, cut-off levels of hs-CRP in women were 2.9, 2.1, and 2.5 mg/L [27.5, 19.7, and 23.5 nmol/L] and corresponding values in men were 2.0, 1.8, and 1.8 mg/L (19.0, 16.9, and 16.9 nmol/L), respectively (sensitivity 60-65% and specificity 54-64%). Our results revealed that hs-CRP may not further strengthen the diagnosis of new-onset DM. Nevertheless, the highest hs-CRP level observed in new-onset DM people diagnosed with HbA1c criterion supports the general assumption that this method might recognize people in more advanced diabetic stage compared with other diagnostic methods.
authors.affiliation: Division of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Tutuncu
authors.affiliation: Division of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Satman
authors.affiliation: Division of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Selda
authors.initials: S
authors.lastname: Celik
authors.affiliation: Division of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Nevin
authors.initials: N
authors.lastname: Dinccag
authors.affiliation: Division of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Kubilay
authors.initials: K
authors.lastname: Karsidag
authors.affiliation: Department of Clinical Biochemistry, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Telci
authors.affiliation: Department of Clinical Biochemistry, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Genc
authors.affiliation: Department of Public Health, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Halim
authors.initials: H
authors.lastname: Issever
authors.affiliation: Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria; Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland; Diabetes Research Group, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.affiliation: Department of Clinical Biochemistry, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Beyhan
authors.initials: B
authors.lastname: Omer
mesh_terms: D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D002097:C-Reactive Protein / Q000032:analysis*; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis*; D005215:Fasting / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D013997:Time Factors; D014421:Turkey
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
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