title: Successful switch from insulin to oral sulfonylurea therapy in HNF1A-MODY Tunisian patient with the P291fsinsC mutation.
abstract: The hot spot mutation P291fsinsC was identified for the first time in a 26 years old Tunisian woman. The low serum level of high C-reactive protein was helpful to target the HNF1A gene. Due to the molecular diagnosis, the change from insulin to sulfonylurea therapy was performed successfully.
authors.affiliation: Biochemistry Laboratory, CHU Farhat Hached, Sousse 4000, Tunisia. Electronic address: souhaira24@yahoo.fr.
authors.forename: Souhaïra Ben
authors.initials: SB
authors.lastname: Khelifa
authors.affiliation: Biochemistry Laboratory, CHU Farhat Hached, Sousse 4000, Tunisia. Electronic address: azzadendana@yahoo.fr.
authors.forename: Azza
authors.initials: A
authors.lastname: Dendana
authors.affiliation: Biochemistry Laboratory, CHU Farhat Hached, Sousse 4000, Tunisia. Electronic address: ilhembarboura@yahoo.fr.
authors.forename: Ilhem
authors.initials: I
authors.lastname: Barboura
authors.affiliation: Endocrinology Unit, University Hospital of Monastir, Monastir 5000, Tunisia. Electronic address: ineskhoc@yahoo.fr.
authors.forename: Ines
authors.initials: I
authors.lastname: Khochtali
authors.affiliation: Biochemistry Laboratory, CHU Farhat Hached, Sousse 4000, Tunisia. Electronic address: hindachahed@yahoo.fr.
authors.forename: Hinda
authors.initials: H
authors.lastname: Chahed
authors.affiliation: Biochemistry Laboratory, CHU Farhat Hached, Sousse 4000, Tunisia. Electronic address: trimechesaly@yahoo.fr.
authors.forename: Selima
authors.initials: S
authors.lastname: Ferchichi
authors.affiliation: Biochemistry Laboratory, CHU Farhat Hached, Sousse 4000, Tunisia. Electronic address: MILED.A@rns.tn.
authors.forename: Abdelhedi
authors.initials: A
authors.lastname: Miled
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004247:DNA / Q000235:genetics*; D004252:DNA Mutational Analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D005260:Female; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007273:Injections, Intramuscular; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D009154:Mutation; D010375:Pedigree; D013453:Sulfonylurea Compounds / Q000008:administration & dosage*; D014416:Tunisia
chemical_list: C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds; D004247:DNA
keywords: HNF1A-MODY; Molecular diagnosis; Monogenic diabetes; Sulfonylurea; hs-CRP