title: Iron-Mediated One-Pot Synthesis of 3,5-Diarylpyridines from β-Nitrostyrenes.
abstract: An operationally simple and mild one-pot protocol for the synthesis of a variety of 3,5-diarylpyridines from β-nitrostyrenes was achieved by using elemental iron. This reaction proceeds via reduction of the nitro group, resulting in in situ imine formation followed by trimolecular condensation with concomitant debenzylative aromatization. By employing this method, a series of symmetrical and unsymmetrical 3,5-diarylpyridines were synthesized with good to excellent yields. In addition, this method was also utilized for the synthesis of Sch-21418, an anti-inflammatory agent on gram scale.
authors.affiliation: Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.
authors.forename: Manda
authors.initials: M
authors.lastname: Sathish
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) , Hyderabad 500 037, India.
authors.forename: Jadala
authors.initials: J
authors.lastname: Chetna
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) , Hyderabad 500 037, India.
authors.forename: Namballa
authors.initials: N
authors.lastname: Hari Krishna
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) , Hyderabad 500 037, India.
authors.forename: Nagula
authors.initials: N
authors.lastname: Shankaraiah
authors.affiliation: Catalytic Chemistry Research Chair, Chemistry Department, College of Science, King Saud University , Riyadh 11451, Saudi Arabia.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Alarifi
authors.affiliation: Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal