title: Assessment of relation between neutrophil lympocyte, platelet lympocyte ratios and epicardial fat thickness in patients with ankylosing spondylitis.
abstract: OBJECTIVE
  To investigate whether there is a relation between neutrophillymphocyte (N/L) and platelet- lymphocyte (P/L) ratios and epicardial adipose tissue (EAT) thickness in patients with ankylosing spondylitis (AS).
  
  
  METHODS
  Thirty patients diagnosed with ankylosing spondylitis and 25 healthy people (controls) were included in the study. Age, gender, body mass index (BMI), height, hemogram, sedimentation, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, CRP, hepatic and renal function tests, lipid profile of the all patients were recorded. Data related to duration of the disease, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) values of the cases in the patient group were obtained. A cardiologist measured EAT thickness by ECHO in both patient and control groups.
  
  
  RESULTS
  In the patient group, mean BASDAI and BASFI scores were 2.48±2.21 and 1.5±2.07, respectively. Age, gender, BMI values did not show statistically significant difference between the patient and the control groups. N/L and P/L ratios did not change significantly in the patient group having higher EAT, BASFI values and taking anti-TNF compared to the control group.
  
  
  CONCLUSIONS
  In patients with AS, EAT measurements, which are related to inflammatory response increase, can be used for monitoring of the risk of development of cardiac disease. We could not find the relation between EAT and N/L, P/L ratios in terms of evaluation of inflammatory response.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Abant Izzet Baysal University Medical Faculty; Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Boyraz
authors.affiliation: Department of Cardiology, Koroglu Training and Research Hospital; Turkey.
authors.forename: Sabri
authors.initials: S
authors.lastname: Onur Caglar
authors.affiliation: Department of Cardiology; Abant Izzet Baysal University Medical Faculty, Bolu; Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Erdem
authors.affiliation: Department of Cardiology; Abant Izzet Baysal University Medical Faculty, Bolu; Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yazici
authors.affiliation: Department of Physical Medicine and Rehabilitation, Abant Izzet Baysal University Medical Faculty; Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Yazici
authors.affiliation: Department of Physical Medicine and Rehabilitation, Abant Izzet Baysal University Medical Faculty; Turkey.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Koc
authors.affiliation: Department of Physical Therapy and Rehabilitation, Karabuk University Medical Faculty, Karabuk; Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Gunduz
authors.affiliation: Aksaray State Hospital, Physical Therapy and Rehabilitation of Department, Aksaray; Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karakoyun
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000473:pathology*; D000328:Adult; D059168:Carotid Intima-Media Thickness; D004452:Echocardiography; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D013167:Spondylitis, Ankylosing / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: ankylosing spondylitis; clinical markers; inflammation