title: [The safety and efficacy of endoscopic versus microscopic surgery for transsphenoidal pituitary adenoma in China: an updated and cumulative meta-analysis].
abstract: OBJECTIVE
  To evaluate the present clinical effectiveness and its change trend by an updated and cumulative meta-analysis of endoscopic versus microscopic surgery for transsphenoidal pituitary adenoma in China.
  
  
  METHODS
  We conducted a systematic review of the literature related to theme,and the meta-analysis of the data extracted onto a standard form was conducted by State 12.0 software.
  
  
  RESULTS
  Finally 14 studies were included. There were 1 888 patients in total including 962 patients receiving endoscopic surgery and 926 patients undergoing microscopic surgery. Compared with microscopic group,there were significant advantages in endoscopic group including the high rate of complete tumor resection (OR=1.951, 95% CI: 1.525-2.495) and the lower incidence of overall operation complication (OR=0.480, 95% CI: 0.298-0.773) and cerebrospinal fluid leakage (OR=0.592, 95% CI: 0.399-0.878), but the advantage of the incidence rate of diabetes insipidus (OR=0.72, 95% CI: 0.420-1.252) was no statistically significant. Cumulative meta-analysis suggested that the advantage of total resection of tumor has stabilized in 2013.
  
  
  CONCLUSIONS
  At present in our country, compared with microscopic group, there were significant advantages in endoscopic group including the rate of complete tumor resection and the incidence of overall operation complications and cerebrospinal fluid leakage, but the advantage of the incidence rate of diabetes insipidus was no statistically significant difference. The follow-up studies related to the rate of total resection of tumor may not change the existing meta-analysis results.
authors.affiliation: Department of Neurosurgery, the Traditional Chinese Medicine (TCM) Hospital Affiliated with Sichuan Medical University, Lu zhou 646000, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, the Traditional Chinese Medicine (TCM) Hospital Affiliated with Sichuan Medical University, Lu zhou 646000, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Peng
authors.affiliation: Department of Neurosurgery, the Traditional Chinese Medicine (TCM) Hospital Affiliated with Sichuan Medical University, Lu zhou 646000, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, the Traditional Chinese Medicine (TCM) Hospital Affiliated with Sichuan Medical University, Lu zhou 646000, China.
authors.forename: Yuhan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, the Traditional Chinese Medicine (TCM) Hospital Affiliated with Sichuan Medical University, Lu zhou 646000, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, the Traditional Chinese Medicine (TCM) Hospital Affiliated with Sichuan Medical University, Lu zhou 646000, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, the Traditional Chinese Medicine (TCM) Hospital Affiliated with Sichuan Medical University, Lu zhou 646000, China; Email: 985153033@qq.com.
authors.forename: Yingjiang
authors.initials: Y
authors.lastname: Gu
mesh_terms: D000236:Adenoma; D065634:Cerebrospinal Fluid Leak; D002681:China; D004724:Endoscopy; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008866:Microsurgery; D010911:Pituitary Neoplasms