title: What's new in estrogen receptor action in the female reproductive tract.
abstract: Estrogen receptor alpha (ERα) is a critical player in development and function of the female reproductive system. Perturbations in ERα response can affect wide-ranging aspects of health in humans as well as in livestock and wildlife. Because of its long-known and broad impact, ERα mechanisms of action continue to be the focus on cutting-edge research efforts. Consequently, novel insights have greatly advanced understanding of every aspect of estrogen signaling. In this review, we attempt to briefly outline the current understanding of ERα mediated mechanisms in the context of the female reproductive system.
authors.affiliation: Receptor Biology GroupReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USASchool of Molecular BiosciencesCollege of Veterinary Medicine, Washington State University, Pullman, Washington 99164, USA.
authors.forename: Sylvia C
authors.initials: SC
authors.lastname: Hewitt
authors.affiliation: Receptor Biology GroupReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USASchool of Molecular BiosciencesCollege of Veterinary Medicine, Washington State University, Pullman, Washington 99164, USA.
authors.forename: Wipawee
authors.initials: W
authors.lastname: Winuthayanon
authors.affiliation: Receptor Biology GroupReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USASchool of Molecular BiosciencesCollege of Veterinary Medicine, Washington State University, Pullman, Washington 99164, USA korach@niehs.nih.gov.
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Korach
mesh_terms: D000818:Animals; D004958:Estradiol / Q000502:physiology; D047628:Estrogen Receptor alpha / Q000737:chemistry / Q000502:physiology*; D047629:Estrogen Receptor beta / Q000502:physiology*; D005260:Female; D015870:Gene Expression; D005786:Gene Expression Regulation; D005836:Genitalia, Female / Q000378:metabolism*; D006801:Humans; D011487:Protein Conformation; D020239:Receptor Cross-Talk; D015398:Signal Transduction
chemical_list: C506487:ESR1 protein, human; C000600034:ESR2 protein, human; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004958:Estradiol
keywords: estrogen receptors; gene expression; gene regulation; hormone action; uterus/endometrium
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