title: Synthesis of cis-[Cr(diimine)2(1-methylimidazole)2](3+) Complexes and an Investigation of Their Interaction with Mononucleotides and Polynucleotides.
abstract: A protocol is presented for the synthesis of chromium(III) complexes of the type cis-[Cr(diimine)2(1-methylimidazole)2](3+). These compounds exhibit large excited-state oxidizing powers and strong luminescence in solution. Emission is quenched by added guanine, yielding rate constants that track the driving force for guanine oxidation. The cis-[Cr(TMP)(DPPZ)(1-MeImid)2](3+) species binds strongly to duplex DNA with a preference for AT base sites in the minor groove and may serve as a precursor for photoactivated DNA covalent adduct formation.
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Goforth
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Gill
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: April E
authors.initials: AE
authors.lastname: Weisbruch
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: Kimberlee A
authors.initials: KA
authors.lastname: Kane-Maguire
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: Marian E
authors.initials: ME
authors.lastname: Helsel
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: Katherine W
authors.initials: KW
authors.lastname: Sun
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: Hillary D
authors.initials: HD
authors.lastname: Rodgers
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: Floyd E
authors.initials: FE
authors.lastname: Stanley
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Goudy
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Wheeler
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: John F
authors.initials: JF
authors.lastname: Wheeler
authors.affiliation: Department of Chemistry, Furman University , Greenville, South Carolina 29613, United States.
authors.forename: Noel A P
authors.initials: NA
authors.lastname: Kane-Maguire
mesh_terms: D001665:Binding Sites; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry*; D010084:Oxidation-Reduction; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007093:Imidazoles; D009711:Nucleotides