title: Exogenous Neural Stem Cells Transplantation as a Potential Therapy for Photothrombotic Ischemia Stroke in Kunming Mice Model.
abstract: Stroke is considered as the second leading cause of death worldwide. The survivors of stroke experience different levels of impairment in brain function resulting in debilitating disabilities. Current therapies for stroke are primarily palliative and may be effective in only a small population of stroke patients. In this study, we explore the transplantation of exogenous neural stem cells (NSCs) as the potential therapy for the photothrombotic ischemia stroke in a Kunming mice model. After stroke, mice receiving NSC transplantation demonstrated a better recovery of brain function during the neurobehavioral tests. Histology analysis of the brain samples from NSC transplanted mice demonstrated a reduction of brain damage caused by stroke. Moreover, immunofluorescence assay for biomarkers in brain sections confirmed that transplanted NSCs indeed differentiated to neurons and astrocytes, consistent with the improved brain function after stroke. Taken together, our data suggested that exogenous NSC transplantation could be a promising therapy for stroke.
authors.affiliation: School of Life Sciences, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730000, Gansu, China.|Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730030, Gansu, China.
authors.forename: Boru
authors.initials: B
authors.lastname: Hou
authors.affiliation: School of Life Sciences, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730000, Gansu, China.|Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730030, Gansu, China.
authors.forename: Junning
authors.initials: J
authors.lastname: Ma
authors.affiliation: School of Life Sciences, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730000, Gansu, China.|Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730030, Gansu, China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730030, Gansu, China.
authors.forename: Furong
authors.initials: F
authors.lastname: Ju
authors.affiliation: Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730030, Gansu, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730030, Gansu, China.
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730030, Gansu, China.
authors.forename: Jixing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730030, Gansu, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Life Sciences, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730000, Gansu, China. sxzhang_lzu@sina.com.
authors.forename: Shengxiang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730030, Gansu, China. haijunren3@163.com.
authors.forename: Haijun
authors.initials: H
authors.lastname: Ren
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000628:therapy*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D058953:Neural Stem Cells / Q000502:physiology / Q000637:transplantation*; D033581:Stem Cell Transplantation / Q000379:methods*; D020521:Stroke / Q000473:pathology / Q000628:therapy*
keywords: Kunming mice model; NSCs transplantation; Neural stem cells; Stroke
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