title: Effect of Carapa guianensis Aublet (Andiroba) and Orbignya phalerata (Babassu) in colonic healing in rats.
abstract: OBJECTIVE
  to evaluate the healing effect of the babassu aqueous extract and andiroba oil on open wounds in the cecum of rats.
  
  
  METHODS
  fifty-four Wistar rats were divided into three groups of 18: 1) babassu group with application of aqueous extract of babassu; 2) andiroba group with application of the oil; and 3) control group, with application of saline solution. All procedures were done by gavage. Each group was divided into three subgroups of six animals according to the observation period of 7, 14 or 21 days. From each animal was removed caecum fragment of 1.5cm² diameter. The areas of the lesions were analyzed macroscopically and resected specimens by light microscopy using hematoxylin-eosin and Masson's trichrome.
  
  
  RESULTS
  abscess and infection were observed in two aroeira group animals, and in one only hematoma. In relationship to adhesions degree, babassu group had higher incidence of grade II while in the control and aroeira groups predominated adhesions grade I. On microscopic examination on day 7 fibroblast proliferation was greater in aroeira and lower in babassu group (p=0.028). On the 14th day polymorphonuclear were less pronounced in babassu (p=0.007). As for the resistance test of air insufflation, it was observed that in all andiroba group in all tested days showed be higher. As for collagen, on the 7th day it was present in 100% of animals of aroeira group. On the 14th day was more pronounced in the control group and at day 21 similar results were found in the control and aroeira groups.
  
  
  CONCLUSIONS
  animals in babassu and andiroba groups showed better cecum healing compared to the control group.
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Instituto de Pesquisas Médicas, Curitiba, PR, Brasil.
authors.forename: Cícero Evandro Soares
authors.initials: CE
authors.lastname: Silva
authors.affiliation: Hospital São Domingos, São Luis, MA, Brasil.
authors.forename: Orlando Jose dos
authors.initials: OJ
authors.lastname: Santos
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Instituto de Pesquisas Médicas, Curitiba, PR, Brasil.
authors.forename: Jurandir Marcondes
authors.initials: JM
authors.lastname: Ribas-Filho
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Instituto de Pesquisas Médicas, Curitiba, PR, Brasil.
authors.forename: Fernando Issamu
authors.initials: FI
authors.lastname: Tabushi
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Instituto de Pesquisas Médicas, Curitiba, PR, Brasil.
authors.forename: Marcio Hiroaki
authors.initials: MH
authors.lastname: Kume
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Instituto de Pesquisas Médicas, Curitiba, PR, Brasil.
authors.forename: Leandro Bressianini
authors.initials: LB
authors.lastname: Jukonis
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Instituto de Pesquisas Médicas, Curitiba, PR, Brasil.
authors.forename: Igor Furlan
authors.initials: IF
authors.lastname: Cella
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D002432:Cecum / Q000293:injuries*; D004195:Disease Models, Animal; D029582:Meliaceae; D008517:Phytotherapy; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts