title: Correlation between periodontal disease management and metabolic control of type 2 diabetes mellitus. A systematic literature review.
abstract: BACKGROUND
  Diabetes and periodontal disease share common features in terms of inflammatory responses. Current scientific evidence suggests that treatment of periodontal disease might contribute to glycemic control. The objective of the study is a review of the last three years.
  
  
  METHODS
  A literature search was performed in the MEDLINE (PubMed), Cochrane, and Scopus databases, for articles published between 01-01-2013 and 30-06-2015, applying the key terms "periodontal disease" AND "diabetes mellitus". The review analyzed clinical trials of humans published in English and Spanish.
  
  
  RESULTS
  Thirteen clinical trials were reviewed, representing a total of 1,912 patients. Three of them had samples of <40 patients, making a total of 108 patients and the remaining ten samples had >40 patients, representing a total of 1,804. Only one article achieved a Jadad score of five. Seven articles (998 patients, 52.3% total), presented a statistically significant decrease in HbA1c (p<0.05) as a result of periodontal treatment. In the six remaining articles (representing 914 patients, 47.8% of the total), the decrease in HbA1c was not significant. Patient follow-up varied between 3 to 12 months. In three articles, the follow-up was of 3, 4, and 9 months, in two 6 and 12 months.
  
  
  CONCLUSIONS
  The majority of clinical trials showed that radicular curettage and smoothing, whether associated with antibiotics or not, can improve periodontal conditions in patients with diabetes mellitus. However, few studies suggest that this periodontal treatment improves metabolic control. However, there is no clear evidence of a relation between periodontal treatment and improved glycemic control in patients with type 2 diabetes mellitus.
authors.affiliation: Department of Odontostomatology, School of Dentistry, Pabellón de Gobierno, Bellvitge University Campus, C/Feixa LLarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain, 18575jll@gmail.com.
authors.forename: F-L
authors.initials: FL
authors.lastname: Pérez-Losada
authors.forename: E
authors.initials: E
authors.lastname: Jané-Salas
authors.forename: M-M
authors.initials: MM
authors.lastname: Sabater-Recolons
authors.forename: A
authors.initials: A
authors.lastname: Estrugo-Devesa
authors.forename: J-J
authors.initials: JJ
authors.lastname: Segura-Egea
authors.forename: J
authors.initials: J
authors.lastname: López-López
mesh_terms: D001786:Blood Glucose; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D006442:Glycated Hemoglobin; D006801:Humans; D010510:Periodontal Diseases / Q000150:complications* / Q000628:therapy*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin
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