title: [Vitamin D insufficiency/deficiency:its clinical significance and treatment].
abstract: Vitamin D insufficiency/deficiency, a medical condition in which vitamin D store is decreased, is the most frequent cause of decreased action of vitamin D. Severer form vitamin D deficiency can cause hypocalcemia and rickets/osteomalacia. Milder form vitamin D insufficiency also harms bone health via secondary hyperparathyroidism, the increase in fracture risk, and poor responses to anti-osteoporotic medications. Diagnosis can only be made by measuring serum 25(OH)D, which is not currently covered by the Japanese health insurance policy. In Japan, the guideline for the diagnosis vitamin D insufficiency/deficiency is in the process of drafting. According to the current provisional guideline draft that was made in public, vitamin D deficiency would be defined by serum 25(OH)D level less than 20 ng/mL whereas vitamin D insufficiency would refer to the state in which serum 25(OH)D level is between 20 and 30 ng/mL.
authors.affiliation: Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Okazaki
mesh_terms: D044466:Asian People; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D006961:Hyperparathyroidism / Q000209:etiology; D006996:Hypocalcemia / Q000209:etiology; D010018:Osteomalacia / Q000209:etiology; D017410:Practice Guidelines as Topic; D011933:Reagent Kits, Diagnostic; D012279:Rickets / Q000209:etiology; D012306:Risk; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D015415:Biomarkers; D011933:Reagent Kits, Diagnostic; D014807:Vitamin D; C104450:25-hydroxyvitamin D