title: Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel.
abstract: Two epimeric metabolites of Larotaxel were synthesized in eight steps from 10-DAB III as a commercial material and their structures were characterized using NMR and MS spectral data. The cytotoxicity of two metabolites was performed on breast cancer cell lines MCF-7, MX-1 and MDA-MB-231. It is remarkable that both of these two desired taxanes showed great potent cytotoxic effect.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Li
authors.forename: Anping
authors.initials: A
authors.lastname: Li
authors.forename: Minghua
authors.initials: M
authors.lastname: Li
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Department of Technology, Shanxi Zhendong Pharmaceutical Co., Ltd., Changzhi, 047100, China. zhanghui1984jc@163.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D006801:Humans; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D043823:Taxoids / Q000494:pharmacology*
chemical_list: D043823:Taxoids; C531079:larotaxel