title: Gingival Metastasis: A Case Report and Literature Review.
abstract: Secondary oral cavity neoplasms are rare. We describe a case of an indurated, nonulcerating gingival lesion in a 59-year-old nonsmoking man with no family history of lung cancer. The lesion was the presenting symptom of metastatic lung adenocarcinoma. Reviewing the literature, we find that primary lung cancer among men is one of the most common cancers to metastasize to the oral cavity. Renal and cutaneous neoplasms are the next most common neoplasms to metastasize to the oral cavity. Furthermore, the gingiva, a tissue prone to inflammation, is noted to be a common site for secondary oral cavity neoplasms. This rare case highlights that metastases should influence the clinician's differential of oral mucosal lesions.
authors.affiliation: Medical Student at the University of California, San Diego School of Medicine in La Jolla, CA. ba.nuyen@gmail.com.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Nuyen
authors.affiliation: Otolaryngologist and Head and Neck Surgeon at the San Francisco Medical Center in CA. christopher.g.tang@kp.org.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Tang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D003937:Diagnosis, Differential; D005887:Gingival Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D014057:Tomography, X-Ray Computed
references.citation: Int J Oral Maxillofac Surg. 2013 Nov;42(11):1391-6
references.pmid: 23870760
references.citation: J Clin Periodontol. 2009 Jun;36(6):488-92
references.pmid: 19508248
references.citation: Oral Oncol. 2008 Aug;44(8):743-52
references.pmid: 18061527
references.citation: Cell. 2011 Mar 4;144(5):646-74
references.pmid: 21376230
references.citation: Int J Oral Maxillofac Surg. 2013 Feb;42(2):164-8
references.pmid: 23196066
references.citation: J Oral Maxillofac Surg. 2013 Jan;71(1):178-88
references.pmid: 22705221
references.citation: Korean J Pathol. 2012 Jun;46(3):266-71
references.pmid: 23110013
references.citation: J Oral Maxillofac Surg. 2013 Sep;71(9):1545-51
references.pmid: 23800673