title: A General Strategy for the Nickel-Catalyzed C-H Alkylation of Anilines.
abstract: The C-H alkylation of aniline derivatives with both primary and secondary alkyl halides was achieved with a versatile nickel catalyst of a vicinal diamine ligand. Step-economic access to functionalized 2-pyrimidyl anilines, key structural motifs in anticancer drugs, is thus provided. The C-H functionalization proceeded through facile C-H activation and SET-type C-X bond cleavage with the assistance of a monodentate directing group, which could be removed in a traceless fashion.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany.
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Ruan
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Lackner
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany. Lutz.Ackermann@chemie.uni-goettingen.de.
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
keywords: C−H activation; alkylation; anilines; nickel; reaction mechanisms