title: Bence-Jones Protein λ-type Multiple Myeloma Patient Withdrawn from Maintenance Hemodialysis after Long-term Bortezomib and Dexamethasone Therapy.
abstract: The effectiveness of bortezomib treatment for multiple myeloma (MM) is well established. However, the protocol by which maintenance therapy using bortezomib should be continued for myeloma patients requiring regular hemodialysis remains to be established. We herein report a case of MM with severe renal insufficiency requiring hemodialysis for nearly 30 months which was finally withdrawn from renal replacement therapy during monthly maintenance treatment with bortezomib and dexamethasone for two years. The details of this case are essential for establishing clinical guidelines for applying intermittent low-frequency bortezomib therapy in dialysis-dependent myeloma patients.
authors.affiliation: Department of Nephrology, Tokyo Medical and Dental University, Japan.
authors.forename: Wakaba
authors.initials: W
authors.lastname: Yamaguchi
authors.forename: Naofumi
authors.initials: N
authors.lastname: Yui
authors.forename: Toshikage
authors.initials: T
authors.lastname: Nagao
authors.forename: Gaku
authors.initials: G
authors.lastname: Oshikawa
authors.forename: Mariko
authors.initials: M
authors.lastname: Negi
authors.forename: Soichiro
authors.initials: S
authors.lastname: Iimori
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Okado
authors.forename: Tatemitsu
authors.initials: T
authors.lastname: Rai
authors.forename: Shinichi
authors.initials: S
authors.lastname: Uchida
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001536:Bence Jones Protein / Q000652:urine*; D000069286:Bortezomib / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000378:metabolism; D017410:Practice Guidelines as Topic; D006435:Renal Dialysis / Q000379:methods*; D051437:Renal Insufficiency / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D000069286:Bortezomib; D003907:Dexamethasone; D001536:Bence Jones Protein