title: Carboxylated and intact osteocalcin predict adiponectin concentration in hemodialyzed patients.
abstract: Purpose Disrupted bone metabolism in patients with chronic kidney disease (CKD) is associated with elevated concentrations of biochemical bone markers. Recently, animal studies show the role of osteocalcin in energy metabolism, which is partially confirmed in humans. The aim of our study was to evaluate the relationships between serum concentrations of bone markers and indices of energy metabolism in CKD patients on maintenance hemodialysis; in particular, the relationship between various forms of osteocalcin and adiponectin. Patients and methods The cross-sectional study included 155 hemodialyzed stage 5 CKD patients. Serum concentrations of glucose, insulin, adiponectin, bone alkaline phosphatase (bALP), tartrate resistant acid phosphatase (TRAP), carboxylated (cOC), undercarboxylated (ucOC), and intact osteocalcin (OC) were determined. Results In total cohort, bALP, TRAP, cOC, and ucOC negatively correlated with BMI. All analyzed bone markers positively correlated with adiponectin in total cohort and in men. In multiple linear regression analysis including all patients, log(cOC) and log(intact OC) were the only bone markers that predicted log(adiponectin) (beta = 0.22; p = 0.016 and beta = 0.26; p = 0.010) independently of sex, dialysis vintage, CRP, insulin, iPTH concentrations, BMI, and age. Conclusions Our data confirm the positive association between cOC, intact OC, and adiponectin concentrations in CKD patients on maintenance hemodialysis.
authors.affiliation: a Chair and Department of Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Marek
authors.initials: M
authors.lastname: Kuźniewski
authors.affiliation: b Chair of Clinical Biochemistry, Diagnostic Department , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Danuta
authors.initials: D
authors.lastname: Fedak
authors.affiliation: c Department of Medical Diagnostics , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Paulina
authors.initials: P
authors.lastname: Dumnicka
authors.affiliation: b Chair of Clinical Biochemistry, Diagnostic Department , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Maria
authors.initials: M
authors.lastname: Kapusta
authors.affiliation: d Department of Medical Physics, M. Smoluchowski Institute of Physics , Jagiellonian University , Kraków , Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Stępień
authors.affiliation: a Chair and Department of Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Eve
authors.initials: E
authors.lastname: Chowaniec
authors.affiliation: a Chair and Department of Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Krzanowska
authors.affiliation: a Chair and Department of Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Marcin
authors.initials: M
authors.lastname: Krzanowski
authors.affiliation: a Chair and Department of Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Chmiel
authors.affiliation: b Chair of Clinical Biochemistry, Diagnostic Department , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Bogdan
authors.initials: B
authors.lastname: Solnica
authors.affiliation: a Chair and Department of Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
authors.forename: Władysław
authors.initials: W
authors.lastname: Sułowicz
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003430:Cross-Sectional Studies; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood*; D012737:Sex Factors
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D015675:Osteocalcin; D000469:Alkaline Phosphatase
keywords: Adiponectin; bone alkaline phosphatase; end stage renal disease; osteocalcin; tartrate resistant acid phosphatase