title: The protective effect of blueberry anthocyanins against perfluorooctanoic acid-induced disturbance in planarian (Dugesia japonica).
abstract: The influence of blueberry anthocyanins on perfluorooctanoic acid (PFOA)-induced stress response in planarian mitochondria was investigated. PFOA at 15mg/L and anthocyanins at 10 or 20mg/L were individually and simultaneously administered to planarians for up to 10d. The results showed PFOA treatment induced an increase in mitochondrial permeability transition pore opening and a decrease antioxidant capacity and enzyme activities. In anthocyanin treated animals, the activity of succinate dehydrogenase, cytochrome oxidase and monoamine oxidase increased, but mitochondrial permeability transition pore opening decreased and total antioxidant capacity increased. An improvement in above-mentioned physiological and biochemical parameters was found in the combined PFOA and anthocyanin treated animals, in a dose-dependent manner. Anthocyanins attenuated the PFOA induced toxicity; antioxidant capacity and enzyme activities are involved in the protective mechanism of anthocyanins.
authors.affiliation: School of Life Sciences, Shandong University of Technology, No. 12 Zhangzhou Road, Zibo, Shandong 255049, China.
authors.forename: Zuoqing
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: School of Life Sciences, Shandong University of Technology, No. 12 Zhangzhou Road, Zibo, Shandong 255049, China. Electronic address: zhangjy1977@126.com.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Shandong University of Technology, No. 12 Zhangzhou Road, Zibo, Shandong 255049, China.
authors.forename: Changchao
authors.initials: C
authors.lastname: Tu
authors.affiliation: School of Life Sciences, Shandong University of Technology, No. 12 Zhangzhou Road, Zibo, Shandong 255049, China.
authors.forename: Zhijing
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Shandong University of Technology, No. 12 Zhangzhou Road, Zibo, Shandong 255049, China.
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Xin
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D029798:Blueberry Plants / Q000737:chemistry*; D002210:Caprylates / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005466:Fluorocarbons / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D010932:Planarians / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D002210:Caprylates; D005466:Fluorocarbons; D010936:Plant Extracts; C023036:perfluorooctanoic acid
keywords: Anthocyanins; Dugesia japonica; Enzyme activities; Mitochondria; Perfluorooctanoic acid (PFOA); Total antioxidant capacity