title: Phase contrast x-ray velocimetry of small animal lungs: optimising imaging rates.
abstract: Chronic lung diseases affect a vast portion of the world's population. One of the key difficulties in accurately diagnosing and treating chronic lung disease is our inability to measure dynamic motion of the lungs in vivo. Phase contrast x-ray imaging (PCXI) allows us to image the lungs in high resolution by exploiting the difference in refractive indices between tissue and air. Combining PCXI with x-ray velocimetry (XV) allows us to track the local motion of the lungs, improving our ability to locate small regions of disease under natural ventilation conditions. Via simulation, we investigate the optimal imaging speed and sequence to capture lung motion in vivo in small animals using XV on both synchrotron and laboratory x-ray sources, balancing the noise inherent in a short exposure with motion blur that results from a long exposure.
authors.affiliation: School of Physics and Astronomy, Monash University, Clayton, VIC, 3800, Australia.
authors.forename: R P
authors.initials: RP
authors.lastname: Murrie
authors.affiliation: School of Physics and Astronomy, Monash University, Clayton, VIC, 3800, Australia.
authors.forename: D M
authors.initials: DM
authors.lastname: Paganin
authors.affiliation: Division of Biological Engineering, Monash University, Clayton, VIC, 3800, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Fouras
authors.affiliation: School of Physics and Astronomy, Monash University, Clayton, VIC, 3800, Australia; Institute for Advanced Study E17, Technische Universität, München, Lichtenbergstrasse 2a, D-85748 Garching, Germany.
authors.forename: K S
authors.initials: KS
authors.lastname: Morgan
keywords: (110.6150) Speckle imaging; (170.7440) X-ray imaging
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