title: The effect of bacterial cellulose membrane compared with collagen membrane on guided bone regeneration.
abstract: OBJECTIVE
  This study was to evaluate the effects of bacterial cellulose (BC) membranes as a barrier membrane on guided bone regeneration (GBR) in comparison with those of the resorbable collagen membranes.
  
  
  METHODS
  BC membranes were fabricated using biomimetic technology. Surface properties were analyzed, Mechanical properties were measured, in vitro cell proliferation test were performed with NIH3T3 cells and in vivo study were performed with rat calvarial defect and histomorphometric analysis was done. The Mann-Whitney U test and the Wilcoxon signed rank test was used (α<.05).
  
  
  RESULTS
  BC membrane showed significantly higher mechanical properties such as wet tensile strength than collagen membrane and represented a three-dimensional multilayered structure cross-linked by nano-fibers with 60 % porosity. In vitro study, cell adhesion and proliferation were observed on BC membrane. However, morphology of the cells was found to be less differentiated, and the cell proliferation rate was lower than those of the cells on collagen membrane. In vivo study, the grafted BC membrane did not induce inflammatory response, and maintained adequate space for bone regeneration. An amount of new bone formation in defect region loaded with BC membrane was significantly similar to that of collagen membrane application.
  
  
  CONCLUSIONS
  BC membrane has potential to be used as a barrier membrane, and efficacy of the membrane on GBR is comparable to that of collagen membrane.
authors.affiliation: Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, YangSan, Republic of Korea.
authors.forename: So-Hyoun
authors.identifier: 0000-0003-3094-6086
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea.
authors.forename: Youn-Mook
authors.initials: YM
authors.lastname: Lim
authors.affiliation: Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea.
authors.forename: Sung In
authors.initials: SI
authors.lastname: Jeong
authors.affiliation: Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea.
authors.forename: Sung-Jun
authors.initials: SJ
authors.lastname: An
authors.affiliation: Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Seong-Soo
authors.initials: SS
authors.lastname: Kang
authors.affiliation: Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, YangSan, Republic of Korea.
authors.forename: Chang-Mo
authors.identifier: 0000-0001-5009-9799
authors.initials: CM
authors.lastname: Jeong
authors.affiliation: Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, YangSan, Republic of Korea.
authors.forename: Jung-Bo
authors.identifier: 0000-0001-7578-1989
authors.initials: JB
authors.lastname: Huh
keywords: Bacterial cellulose membrane; Collagen membrane; Guided bone regeneration; Rat calvarial defect
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