title: Predicting Mid-term All-cause Mortality in Patients Undergoing Elective Endovascular Repair of a Descending Thoracic Aortic Aneurysm.
abstract: BACKGROUND
  All-cause mortality in patients after repair of aortic aneurysms of the descending thoracic aorta thoracic endovascular aortic repair (TEVAR) is relatively high at mid-term follow-up. The aim of this study was to derive and validate a system that could predict all-cause mortality after TEVAR to aid with patient selection.
  
  
  METHODS
  The MOTHER database contained 625 patients that underwent elective surgery for descending thoracic aortic aneurysms. Univariate analysis identified preoperative factors associated with mid-term all-cause mortality, and a Cox proportional hazards model was developed. The model was internally validated using Kaplan-Meier comparison of observed vs predicted mortality. External validation was performed using a data set from the University of Florida College of Medicine.
  
  
  RESULTS
  There were 625 patients that underwent TEVAR for descending thoracic aortic aneurysm in the MOTHER database and 231 in the University of Florida College of Medicine validation set. The mid-term mortality rate at 6 years of follow-up was 34.4% and 34%, respectively. The all-cause mortality risk score was calculated using 0.0398 × (age) + 0.516 × (renal insufficiency) + 0.46 × (previous cerebrovascular disease) + 0.352 × (prior tobacco use) + 0.376 × (number of devices >2) + 0.016 × (maximum aneurysm diameter). Using this score, low-, medium-, and high-risk groups were defined, with predicted survival at 5 years of 80%, 60%, and 40%. Patients at high risk of mid-term all-cause death were identified in the validation cohort using the prediction rule.
  
  
  CONCLUSIONS
  Identifying patients with a limited life expectancy after TEVAR is possible using a preoperative risk-stratification system. This information can be used to inform decision making regarding when and whether to proceed with TEVAR.
authors.affiliation: *St George's Vascular Institute, St George's Hospital, London, UK†Department of Community Health Sciences, St Georges's University of London, London, UK‡Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, FL.
authors.forename: Benjamin O
authors.initials: BO
authors.lastname: Patterson
authors.forename: Alberto
authors.initials: A
authors.lastname: Vidal-Diez
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Holt
authors.forename: Salvatore T
authors.initials: ST
authors.lastname: Scali
authors.forename: Adam W
authors.initials: AW
authors.lastname: Beck
authors.forename: Matt M
authors.initials: MM
authors.lastname: Thompson
mesh_terms: D000368:Aged; D017545:Aortic Aneurysm, Thoracic / Q000401:mortality* / Q000601:surgery*; D002423:Cause of Death; D057510:Endovascular Procedures / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies