title: [Design, synthesis and antiproliferative activity in cancer cells of novel 18β-glycyrrhetinic acid derivatives].
abstract: To investigate the anticancer effects of ring C in 18β-glycyrrhetinic acid (GA), a series of GA derivatives featured with 9(11)-ene moiety in ring C were designed and synthesized. The structures were confirmed by IR, LC-MS and 1H NMR. Their inhibitory effects towards human prostate cancer PC-3 and leukemia HL-60 cell lines were determined. Most of the derivatives displayed stronger antiproliferative activities than GA. Particularly, compound 14 showed promising anticancer activity with the GI50 values of 4.48 µmol · L(-1) and 1.2 µmol · L(-1) against PC-3 and HL-60 cells respectively, which is worth further study.
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.forename: Kun
authors.initials: K
authors.lastname: Li
authors.forename: Shu-yu
authors.initials: SY
authors.lastname: Jin
authors.forename: Ting-xiu
authors.initials: TX
authors.lastname: Cui
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Lin-xiang
authors.initials: LX
authors.lastname: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; C119129:18alpha-glycyrrhetinic acid; D006034:Glycyrrhetinic Acid