title: Interleukin-10 -1082A/G polymorphism is associated with the development of acute pancreatitis in a Chinese population.
abstract: We conducted a case-control study to investigate the association between IL-10 gene polymorphism (-1082A/G, -819T/C, and -592A/C) and risk of acute pancreatitis in a Chinese population. A total of 240 patients with proven acute pancreatitis and 240 control subjects were collected between May 2012 and January 2015. Genotyping of the IL-10-1082A/G, -819T/C, and -592A/C gene polymorphisms was conducted by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. By univariate logistic regression analysis, patients with acute pancreatitis were more likely to have higher BMI (OR=2.12, 95% CI=1.45-3.12; P<0.001) and have a habit of alcohol drinking (OR=2.01, 95% CI=1.37-2.95; P<0.001). There were significant differences in the genotype distributions of IL-10-1082A/G between patients with acute pancreatitis and control subjects (χ(2)=9.97, P=0.007). By multiple logistic regression analysis, we found that individuals with the GG genotype of IL-10-1082A/G were associated with an increased risk of acute pancreatitis when compared with the AA genotype (OR=2.32, 95% CI=1.20-4.59; P=0.007). In dominant and recessive models, the IL-10-1082A/G gene polymorphism was significantly correlated with an elevated risk of acute pancreatitis, and the adjusted Ors (95% CI) were 1.50 (1.03-2.20) and 1.99 (1.06-3.79), respectively. However, no significant different was found between IL-10-819T/C and -592A/C gene polymorphisms and susceptibility to acute pancreatitis. In conclusion, we suggest that IL-10-1082A/G gene polymorphisms contribute to the development of acute pancreatitis in codominant, dominant and recessive models.
authors.affiliation: Department of General Surgery, The First People's Hospital of Shangqiu Shangqiu 476100, Henan, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Cai
authors.affiliation: Department of General Surgery, The First People's Hospital of Shangqiu Shangqiu 476100, Henan, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Cui
authors.affiliation: Department of Clinical Medicine, Shangqiu Medical College Shangqiu 476100, Henan, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Clinical Medicine, Shangqiu Medical College Shangqiu 476100, Henan, China.
authors.forename: Xueli
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Clinical Medicine, Shangqiu Medical College Shangqiu 476100, Henan, China.
authors.forename: Guihong
authors.initials: G
authors.lastname: Qiao
authors.affiliation: Internal Medicine, Shaanxi Provincial People's Hospital Xi'an 710068, Shanxi, China.
authors.forename: Danping
authors.initials: D
authors.lastname: Liu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: -1082A/G; -592A/C; -819T/C; Interleukin-10; acute pancreatitis; polymorphism
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