title: Maternal immune activation alters glutamic acid decarboxylase-67 expression in the brains of adult rat offspring.
abstract: Activation of the maternal innate immune system, termed "maternal immune activation" (MIA), represents a common environmental risk factor for schizophrenia. Whereas evidence suggests dysregulation of GABA systems may underlie the pathophysiology of schizophrenia, a role for MIA in alteration of GABAergic systems is less clear. Here, pregnant rats received either the viral mimetic polyriboinosinic-polyribocytidilic acid or vehicle injection on gestational day 14. Glutamic acid decarboxylase-67 (GAD67) mRNA expression was examined in male offspring at postnatal day (P)14, P30 and P60. At P60, GAD67 mRNA was elevated in hippocampus and thalamus and decreased in prefrontal cortex of MIA offspring. MIA-induced alterations in GAD expression could contribute to the pathophysiology of schizophrenia.
authors.affiliation: Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45267, USA.
authors.forename: Sarah N
authors.initials: SN
authors.lastname: Cassella
authors.affiliation: Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Hemmerle
authors.affiliation: Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
authors.forename: Kerstin H
authors.initials: KH
authors.lastname: Lundgren
authors.affiliation: Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45267, USA.
authors.forename: Tara L
authors.initials: TL
authors.lastname: Kyser
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Ahlbrand
authors.affiliation: Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45267, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
authors.forename: Stefanie L
authors.initials: SL
authors.lastname: Bronson
authors.affiliation: Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45267, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; San Diego Veterans Affairs Healthcare System, San Diego, CA 92161, USA; Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA.
authors.forename: Neil M
authors.initials: NM
authors.lastname: Richtand
authors.affiliation: Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45267, USA. Electronic address: kim.seroogy@uc.edu.
authors.forename: Kim B
authors.initials: KB
authors.lastname: Seroogy
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D001921:Brain / Q000201:enzymology*; D004195:Disease Models, Animal; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000502:physiology*; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism*; D007369:Interferon Inducers / Q000633:toxicity; D008297:Male; D011070:Poly I-C / Q000633:toxicity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000473:pathology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007369:Interferon Inducers; D012333:RNA, Messenger; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1; D011070:Poly I-C
keywords: GABA; GAD; Inflammation; MIA; Poly I:C; Schizophrenia; mRNA
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