title: Optimum combination therapy regimens for HIV/HCV infection.
abstract: HIV-HCV co-infection mostly affects intravenous drug users, in whom prevalence has tended to decrease in recent years, while it has increased in men who have sex with men, with occurrence of acute hepatitis C. Hepatitis C has a poorer prognosis in patients co-infected with HIV, as clinical progression is faster and degree of hepatic fibrosis is greater. However, optimized ARV treatment is clearly associated with slower progression to hepatic complications. Interactions between HCV and HIV drugs are numerous, which underlines the importance of pharmacological advice for HIV-treated patients before they start HCV treatment. In HIV-HCV co-infection, treatment of hepatitis C has to be offered as in mono-infected patients (US and European countries) or to all patients (French guidelines). In most patients, HCV eradication is achieved with different DAA associations, the choice and duration being driven by HCV genotype, hepatic fibrosis stage, and whether patients have been previously treated or not.
authors.affiliation: a Le Trait d'Union, Center for HIV Care, NHC , Hôpitaux Universitaires , Strasbourg , France.
authors.forename: David
authors.initials: D
authors.lastname: Rey
authors.affiliation: b Laboratoire de Pharmacologie Clinique , INSERM U1098 , CHRU Besançon , France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Muret
authors.affiliation: c Infectious Diseases Department, Centre Hospitalier Universitaire and UMR 1347 , Université de Bourgogne , Dijon , France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Piroth
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D060085:Coinfection / Q000188:drug therapy*; D004347:Drug Interactions; D004359:Drug Therapy, Combination / Q000009:adverse effects; D015658:HIV Infections / Q000188:drug therapy*; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans
chemical_list: D000998:Antiviral Agents
keywords: DAAs; HCV eradication; HCV treatment; HIV treatment; HIV-HCV co-infection; antiretrovirals; drug-drug interactions; hepatic fibrosis; intravenous drug users; men who have sex with men