title: Evaluation of cerebral function in high risk term infants by using a scoring system based on aEEG.
abstract: OBJECTIVE
  To investigate the relationship between the amplitude integrated electroencephalogram (aEEG) findings and neurodevelopmental outcomes of high-risk term infants with neurological disorders and develop a scoring system for assessment of the cerebral function.
  
  
  METHODS
  The neurological outcome was assessed at 12- to 18-month of age by using the Bayley Scales of Infant Development II. Valuation of the classification of aEEG background pattern, epileptic electrical activity and sleep-weak cycle (SWC) was conducted to develop a new scoring system. The correlation between the summarized scores and outcome analyzed, and the predictive test of the score system was calculated.
  
  
  RESULTS
  A total of 81 infants (39 with asphyxia, 10 with hypoglycemia, 15 with acute bacterial meningoencephalitis, 10 with hyperbilirubinemia and 7 with inborn errors of metabolism) enrolled in the study. The neurological outcome was positive correlated with the background pattern, electrical activity, SWC and summarized scores of the score system based on aEEG. The scoring system has a higher r value, specificity, PPV and lower sensitivity compared with the separate entities such as background pattern, seizures and SWC. The area under the receiver operator characteristics (ROC) curve for predicting outcome by the scoring system was 0.93 (95% CI, 0.878-0.990), with the cut-off value of 7.5.
  
  
  CONCLUSIONS
  aEEG maybe a potential tool for monitoring cerebral function in term infants at risk for poor neurodevelopmental outcomes. Our proposed scoring system based on aEEG could quantify information provided by aEEG objectively and could be a good predictor for neurological outcome.
authors.affiliation: Department of Neonatal Intensive Care Unit, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Luo
authors.affiliation: Department of Neonatal Intensive Care Unit, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Neonatal Intensive Care Unit, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Huijia
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Neonatal Intensive Care Unit, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Chenhong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neonatal Intensive Care Unit, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Neonatal Intensive Care Unit, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Shi
keywords: Amplitude integrated electroencephalogram (aEEG); full-term infant; neurological disorders
references.citation: Arch Dis Child. 1983 Dec;58(12):997-1002
references.pmid: 6660900
references.citation: Br Med J. 1971 Jun 26;2(5764):736-8
references.pmid: 4326286
references.citation: Pediatr Neurol. 2006 Nov;35(5):335-42
references.pmid: 17074604
references.citation: Neurology. 2000 Aug 22;55(4):506-13
references.pmid: 10953181
references.citation: Zhongguo Dang Dai Er Ke Za Zhi. 2008 Apr;10(2):115-20
references.pmid: 18433524
references.citation: J Pediatr. 2002 Apr;140(4):396-403
references.pmid: 12006952
references.citation: Pediatrics. 2010 Feb;125(2):e358-66
references.pmid: 20100767
references.citation: BMJ. 1999 Oct 16;319(7216):1054-9
references.pmid: 10521205
references.citation: J Cereb Blood Flow Metab. 1983 Mar;3(1):78-85
references.pmid: 6822622
references.citation: J Pediatr. 2011 Nov;159(5):755-760.e1
references.pmid: 21658714
references.citation: Pediatr Neurol. 2009 Nov;41(5):315-26
references.pmid: 19818932
references.citation: Neonatology. 2012;102(2):120-5
references.pmid: 22699267
references.citation: Pediatrics. 2003 Oct;112(4):855-61
references.pmid: 14523177
references.citation: Arch Dis Child Fetal Neonatal Ed. 1999 Jul;81(1):F19-23
references.pmid: 10375357
references.citation: Pediatr Res. 2004 Jun;55(6):1026-33
references.pmid: 15155870
references.citation: Lancet. 2005 Feb 19-25;365(9460):663-70
references.pmid: 15721471
references.citation: Arch Neurol. 1976 Oct;33(10):696-705
references.pmid: 987769
references.citation: Acta Paediatr. 2010 Feb;99(2):194-200
references.pmid: 19889102
references.citation: Pediatrics. 2005 Feb;115(2):327-32
references.pmid: 15687440
references.citation: Pediatrics. 1999 Jun;103(6 Pt 1):1263-71
references.pmid: 10353940
references.citation: Pediatrics. 2008 Jul;122(1):65-74
references.pmid: 18595988
references.citation: Pediatrics. 2011 May;127(5):e1280-7
references.pmid: 21482614
references.citation: J Neurosci. 2003 Dec 17;23(37):11505-15
references.pmid: 14684854
references.citation: Neonatology. 2012;102(3):203-11
references.pmid: 22797054
references.citation: Neuroscience. 1999;92(4):1443-54
references.pmid: 10426498
references.citation: Br Med J. 1969 Nov 29;4(5682):545-6
references.pmid: 5354856
references.citation: Pediatr Neurol. 2006 Mar;34(3):194-9
references.pmid: 16504788
references.citation: Pediatr Neurol. 2005 Apr;32(4):241-7
references.pmid: 15797180
references.citation: Semin Fetal Neonatal Med. 2006 Dec;11(6):503-11
references.pmid: 17067863