title: Bull serum albumin coated Au@Agnanorods as SERS probes for ultrasensitive osteosarcoma cell detection.
abstract: Surface-Enhanced Raman scattering (SERS) has been widely used for imaging and sensing. However, limited reports are currently available on SERS-based cancer cell targeting strategy due to the challenge of synthesizing highly sensitive, reproducible and biocompatible SERS probe. Herein, we developed novel SERS probes, based on BSA (Bull Serum Albumin) coated gold-silver core-shell nanorods modified with Raman reporter 5,5-dithiobis 2-nitrobenzoic acid (DTNB) (Au@AgNRs@BSA@Anti-MICA), for in vitro cancer cell detection. Our results demonstrate that the SERS probe is very robust for cancer cell ultrasensitive detection with good biocompatibility and strong SERS signal.
authors.affiliation: Department of Spinal Cord Repairing, General Hospital of Jinan Military Area Command, Shifan Road 25, 250000 Jinan, Shandong, PR China.
authors.forename: Ji
authors.initials: J
authors.lastname: Yue
authors.affiliation: Department of Oncology, Center Hospital of Feicheng Mining, 271600 Taian, Shandong, PR China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Joint Motion, Center Hospital of Tengzhou, 277500 Shandong, PR China.
authors.forename: Xingyu
authors.initials: X
authors.lastname: Cai
authors.affiliation: School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China.
authors.forename: Xianting
authors.initials: X
authors.lastname: Ding
authors.affiliation: School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China. Electronic address: chenshouhui1982@163.com.
authors.forename: Shouhui
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Burn and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Changlexi Road 17, 710032 Xi'An, PR China. Electronic address: taokehopital@163.com.
authors.forename: Ke
authors.initials: K
authors.lastname: Tao
authors.affiliation: Department of Spinal Cord Repairing, General Hospital of Jinan Military Area Command, Shifan Road 25, 250000 Jinan, Shandong, PR China. Electronic address: zhaotingbao1020@163.com.
authors.forename: Tingbao
authors.initials: T
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000175:diagnosis; D002417:Cattle; D049109:Cell Proliferation; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D012516:Osteosarcoma / Q000175:diagnosis*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*; D014407:Tumor Cells, Cultured
chemical_list: D012710:Serum Albumin, Bovine; D012834:Silver; D006046:Gold
keywords: Au@AgNRs@BSA; Cancer detection; Osteosarcoma; SERS