title: Antibacterial metabolites from the Actinomycete Streptomyces sp. P294.
abstract: The Actinomycete strain P294 was isolated from soil and identified as Streptomyces sp. based upon the results of 16S rRNA sequence analysis. Three compounds obtained from the solid fermentation products of this strain have been determined by 1D, 2D NMR and HRMS experiments. These compounds include two new compounds angumycinones C (1) and D (2), and the known compound X-14881 E (3). All compounds were assayed for antibacterial and nematicidal activity. The results showed the three compounds had different degrees of inhibitory activity against several target bacteria but no significant toxicity against the nematode Caenorhabditis elegans.
authors.affiliation: Key Laboratory for Conservation and Utilization of Bio-resource, and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, 650091, Yunnan, P. R. China.
authors.forename: Huining
authors.initials: H
authors.lastname: Su
authors.affiliation: Angang General Hospital, Anshan, 114021, P. R. China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Shao
authors.affiliation: Key Laboratory for Conservation and Utilization of Bio-resource, and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, 650091, Yunnan, P. R. China.
authors.forename: Keqin
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Conservation and Utilization of Bio-resource, and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, 650091, Yunnan, P. R. China. ligh@ynu.edu.cn.
authors.forename: Guohong
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001419:Bacteria / Q000187:drug effects*; D017173:Caenorhabditis elegans / Q000187:drug effects; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D012988:Soil Microbiology; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S
keywords: Streptomyces sp.; antibacterial activity; nematicidal activity; new compounds
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