title: Biocompatibility of new Ti-Nb-Ta base alloys.
abstract: β-type titanium alloys are promising materials in the field of medical implants. The effect of β-phase stability on the mechanical properties, corrosion resistance and cytotoxicity of a newly designed β-type (Ti77Nb17Ta6) biocompatible alloys are studied. The β-phase stability was controlled by the addition of small quantities of Fe and O. X-ray diffraction and microstructural analysis showed that the addition of O and Fe stabilized the β-phase in the treated solution condition. The strength and hardness have increased with the increase in β-phase stability while ductility and Young's modulus have decreased. The potentio-dynamic polarization tests showed that the corrosion resistance of the new alloys is better than Ti-6Al-4V alloy by at least ten times. Neutral red uptake assay cytotoxicity test showed cell viability of at least 95%. The new alloys are promising candidates for biomedical applications due to their high mechanical properties, corrosion resistance, and reduced cytotoxicity.
authors.affiliation: Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.
authors.forename: Abdelrahman H
authors.initials: AH
authors.lastname: Hussein
authors.affiliation: Department of Materials Science and Engineering, Egypt-Japan University of Science and Technology, Alexandria, Egypt.
authors.forename: Mohamed A-H
authors.initials: MA
authors.lastname: Gepreel
authors.affiliation: Department of Materials Science and Engineering, Egypt-Japan University of Science and Technology, Alexandria, Egypt.
authors.forename: Mohamed K
authors.initials: MK
authors.lastname: Gouda
authors.affiliation: Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.
authors.forename: Ahmad M
authors.initials: AM
authors.lastname: Hefnawy
authors.affiliation: Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.
authors.forename: Sherif H
authors.initials: SH
authors.lastname: Kandil
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D006244:Hardness; D006367:HeLa Cells; D006801:Humans; D008422:Materials Testing; D009556:Niobium / Q000737:chemistry / Q000494:pharmacology; D013635:Tantalum / Q000737:chemistry / Q000494:pharmacology; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000497:Alloys; D009556:Niobium; D013635:Tantalum; D014025:Titanium
keywords: Biocompatibility; Corrosion; Cytotoxicity; Titanium alloys; β-phase stability