title: Factors Associated with High-sensitivity Cardiac Troponin T in Patients with Type 2 Diabetes Mellitus.
abstract: BACKGROUND
  The blood concentration of high-sensitivity cardiac troponin T (hs-cTnT) is an established, useful biomarker for evaluating the pathogenesis of heart failure and predicting cardiovascular events. The aim of this study was to evaluate factors that are potentially associated with elevated blood hs-cTnT in patients with type 2 diabetes mellitus.
  
  
  METHODS
  Patients with type 2 diabetes mellitus (N=280, 111 men and 169 women; mean ± SD age: 71±9 years) with no history of cardiovascular events were enrolled. Relationships between hs-cTnT level and various clinical parameters were examined.
  
  
  RESULTS
  Hs-cTnT was detected in 244 (87.1%) patients. There were no significant relationships between hs-cTnT and fasting blood glucose levels or insulin resistance. hs-cTnT was significantly correlated with advanced glycation end-product levels at the skin (r=0.23, p<0.001), blood concentrations of brain natriuretic peptide (r=0.23, p<0.001), reactive oxygen metabolites as markers of oxidative stress (r=0.28, p<0.001), and the augmentation index at the radial artery as marker of arterial reflection (r=0.31, p<0.001). Furthermore, multiple regression analysis revealed that these factors were also selected as independent variables, with hs-cTnT as a subordinate factor.
  
  
  CONCLUSIONS
  These results indicate that novel cardiovascular risk factors including advanced glycation end-products, in vivo oxidative stress, and high arterial reflection are closely associated with high concentrations of blood hs-cTnT in patients with type 2 diabetes mellitus.
authors.affiliation: Hitsumoto Medical Clinic.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hitsumoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D017382:Reactive Oxygen Species / Q000378:metabolism; D012044:Regression Analysis; D012307:Risk Factors; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D020097:Natriuretic Peptide, Brain; D017382:Reactive Oxygen Species; D020107:Troponin T