title: Synthesis and Cytoxicity of Sempervirine and Analogues.
abstract: Sempervirine and analogues were synthesized using a route featuring Sonogashira and Larock Pd-catalyzed reactions. Structure-activity relationships were investigated using three human cancer cell lines. 10-Fluorosempervirine is the most potently cytotoxic member of the family yet described.
authors.affiliation: Department of Chemistry, The Scripps Research Institute , Jupiter, Florida 33458, United States.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Tumor Biology, Moffitt Cancer Center & Research Institute , Tampa, Florida 33612, United States.
authors.forename: Chunying
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Tumor Biology, Moffitt Cancer Center & Research Institute , Tampa, Florida 33612, United States.
authors.forename: John L
authors.initials: JL
authors.lastname: Cleveland
authors.affiliation: Department of Chemistry, The Scripps Research Institute , Jupiter, Florida 33458, United States.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Bannister
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D046948:Secologanin Tryptamine Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C000611329:10-fluorosempervirine; D000970:Antineoplastic Agents; D046948:Secologanin Tryptamine Alkaloids; D010165:Palladium; C009234:sempervirine
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