title: Development of cetyl dimethicone based water-in-oil emulsion containing botanicals: Physical characteristics and stability.
abstract: The aim of current research was to develop a water-in-oil emulsion containing grape seed extract for application in cosmeceuticals. Finally grinded dried grape seeds powder was extracted with hydro alcoholic mixture. Emulsions consisting of different concentrations of cetyl dimethicone (Abile EM90), the nonionic emulsifier, liquid paraffin as oily phase and water as aqueous phase were developed. Color, odor, pH, viscosity, liquefaction, phase separation, centrifugation and thermal stability of the formulated emulsions were observed at various storage temperatures i.e. 8±0.5°C, 25±0.5°C, 40±0.5°C and 40°C±0.5°C with 70% RH. The stable formulation consist of 16% mineral oil, 4% of ABIL EM 90(®), 4% grape seeds extract, 1% rose oil and 75% distilled water. All the results derived from this study showed good stability over the three months study period which indicates w/o emulsion can be used as carrier of 4% grape seeds extract to enhance desired effects when applied topically.
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islaima University of Bahawalpur, Pakistan.
authors.forename: Muhammad Khurram
authors.initials: MK
authors.lastname: Waqas
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islaima University of Bahawalpur, Pakistan.
authors.forename: Naveed
authors.initials: N
authors.lastname: Akhtar
authors.affiliation: University college of Pharmacy, Punjab University, Lahore, Pakistan.
authors.forename: Pervaiz Akhtar
authors.initials: PA
authors.lastname: Shah
authors.affiliation: University college of Pharmacy, Punjab University, Lahore, Pakistan.
authors.forename: Muhammad Zeeshan
authors.initials: MZ
authors.lastname: Danish
authors.affiliation: School of Pharmacy, University of South Asia, Lahore, Pakistan.
authors.forename: Arshad Ali
authors.initials: AA
authors.lastname: Shah
authors.affiliation: Laboratory of Biotechnology, Federal University of Paraiba, João Pessoa, Brazil.
authors.forename: Valdir de Andrade
authors.initials: Vde A
authors.lastname: Braga
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islaima University of Bahawalpur, Pakistan.
authors.forename: Barkat Ali
authors.initials: BA
authors.lastname: Khan
mesh_terms: D004355:Drug Stability; D004655:Emulsions; D056604:Grape Seed Extract / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D014297:Trimethylsilyl Compounds / Q000737:chemistry*; D014783:Viscosity
chemical_list: C582464:Abil EM90; D004655:Emulsions; D056604:Grape Seed Extract; D014297:Trimethylsilyl Compounds