title: Impact of young age on local control after partial breast irradiation in Japanese patients with early stage breast cancer.
abstract: BACKGROUND
  Partial breast irradiation (PBI) is an alternative to whole breast irradiation (WBI) for breast-conserving therapy (BCT). A randomised phase 3 trial demonstrated that PBI using multicatheter brachytherapy had an equivalent rate of local recurrence, disease-free survival, and overall survival as compared to WBI. However, limited data are available on PBI efficacy for young patients with breast cancer.
  
  
  METHODS
  We evaluated consecutive patients with Tis-2 (≤ 3 cm) N0-1 breast cancer who underwent BCT. For PBI, patients received radiotherapy using multicatheter brachytherapy in an accelerated manner with a dose of 32 Gy in eight fractions over 5-6 days. For WBI, patients received an external beam radiation therapy that was applied to the entire breast with a total dose of 50 Gy in fractions of 2 Gy for 5 weeks. Two hundred seventy-four patients with 278 lesions received PBI; 190 patients with 193 lesions received WBI.
  
  
  RESULTS
  Patients aged <50 years including 98 women with 99 lesions receiving PBI and 85 women with 85 lesions receiving WBI were selected. Ipsilateral breast tumor recurrence rate was 3.0 and 2.4 % by PBI and WBI, respectively (P = 0.99). There was no significant difference in 4-year probability of disease-free survival (97.6 and 91.4 % for PBI and WBI, respectively; P = 0.87).
  
  
  CONCLUSIONS
  This is the first report of PBI efficacy in young patients in Asia. Although it is a nonrandomized retrospective chart review of a small cohort of patients with a relatively short follow-up period, PBI may be a better option than WBI following BCS in some young patients with breast cancer.
authors.affiliation: Department of Breast Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo, 196-0003, Japan. kazsato.boc@gmail.com.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Breast Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo, 196-0003, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Mizuno
authors.affiliation: Department of Breast Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo, 196-0003, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Fuchikami
authors.affiliation: Department of Radiation Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo, 196-0003, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kato
authors.affiliation: Department of Radiation Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo, 196-0003, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shimo
authors.affiliation: Department of Radiation Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo, 196-0003, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kubota
authors.affiliation: Department of Breast Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo, 196-0003, Japan.|Inoue Ladies Clinic, 1-26-9 Fujimi, Tachikawa, Tokyo, 190-0013, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Takeda
authors.affiliation: Inoue Ladies Clinic, 1-26-9 Fujimi, Tachikawa, Tokyo, 190-0013, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Seto Hospital, 8-6 Kanayama, Tokorozawa, Saitama, 359-1128, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Seto
authors.affiliation: Health Evaluation Center, Utsunomiya Memorial Hospital, 1-3-16 Odori, Utsunomiya, Tochigi, 320-0811, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Okawa
mesh_terms: D000328:Adult; D000367:Age Factors; D044466:Asian People; D001918:Brachytherapy / Q000379:methods; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D016896:Treatment Outcome
keywords: Brachytherapy; Breast cancer; Partial breast irradiation; Young