title: Mixed lineage kinase domain-like protein is a prognostic biomarker for cervical squamous cell cancer.
abstract: BACKGROUND
  The mixed lineage kinase domain-like protein (MLKL) has recently been identified as a key RIP3 (receptor interacting protein 3) downstream component of tumor necrosis factor (TNF)-induced necroptosis.
  
  
  OBJECTIVE
  To evaluate the expression and clinical significance of MLKL in cervical squamous cell carcinoma.
  
  
  METHODS
  The expression of MLKL in 54 cervical squamous carcinoma samples was detected by immuneohistochemical method. Chi-square, correlation analysis and kaplan-Meier method were used to analyze the data.
  
  
  RESULTS
  The MLKL expression in cervical squamous cell carcinoma was higher than that in normal cervical tissues (P = 0.004). The MLKL expression was negatively correlated with histological grade, lymphatic metastasis (P<0.05). Survival analysis showed the low expression of MLKL indicated poor prognosis.
  
  
  CONCLUSIONS
  MLKL was a prognostic biomarker for cervical squamous cell carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Renmin South Road, Chengdu 610041, China.
authors.forename: Jiaying
authors.initials: J
authors.lastname: Ruan
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Renmin South Road, Chengdu 610041, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Mei
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Renmin South Road, Chengdu 610041, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Renmin South Road, Chengdu 610041, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Shi
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Renmin South Road, Chengdu 610041, China.
authors.forename: He
authors.initials: H
authors.lastname: Wang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D011494:Protein Kinases / Q000032:analysis / Q000096:biosynthesis*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C570693:MLKL protein, human; D011494:Protein Kinases
keywords: Cervical squamous cell carcinoma; MLKL; immunohistochemistry; phosphorylate
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