title: Meta-analysis of the efficacy of lansoprazole and omeprazole for the treatment of H.pylori-associated duodenal ulcer.
abstract: OBJECTIVE
  To conduct a systematic evaluation of the efficacy of lansoprazole and omeprazole for the treatment of Helicobacter pylori-associated duodenal ulcer.
  
  
  METHODS
  Online databases, including CHKD, VIP, China Info, the National Digital Library of China, Google Scholar, PubMed, Lippincott Williams & Wilkins, and Wiley Online Library were searched for related studies. The quality of the studies was evaluated in accordance with the Cochrane Handbook for Systematic Reviews of Interventions, and relevant information was extracted from them. The studies were subjected to meta-analysis using RevMan5.3 software, and qualitative analysis was performed for studies, in which the data could not be merged.
  
  
  RESULTS
  A total of nine randomized controlled trials (RCTs) were included, all of which presented the possibility of bias. Meta-analysis showed no significant differences between patients treated with lansoprazole combinations and omeprazole combinations in terms of DU healing rate (RR = 1.04, 95% CI = 0.99~1.09, P = 0.93). There were significant differences between those treated by lansoprazole combination and omeprazole combination in terms of HP eradication rate (RR = 1.09, 95% CI = 1.01~1.18, P = 0.04), and there was no serious adverse reaction during the treatment process for both lansoprazole and omeprazole.
  
  
  CONCLUSIONS
  Lansoprazole and omeprazole exhibit similar efficacy in the treatment of Helicobacter pylori associated duodenal ulcers.
authors.affiliation: Department of Pharmacy, Guigang People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University Guigang 537100, Guangxi, Zhuang Autonomous Region, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Department of Pharmacy, Youjiang Medical University for Nationalities Baise 533000, Guangxi, Zhuang Autonomous Region, P. R. China.
authors.forename: Yutong
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Pharmacy, Youjiang Medical University for Nationalities Baise 533000, Guangxi, Zhuang Autonomous Region, P. R. China.
authors.forename: Desen
authors.initials: D
authors.lastname: Liang
authors.affiliation: Department of Pharmacy, Guigang People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University Guigang 537100, Guangxi, Zhuang Autonomous Region, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Guo
authors.affiliation: School of Public Policy and Administration, Xi'an Jiaotong University Xi'an 710049, Shaanxi Province, P. R. China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Li
keywords: HP infection; Lansoprazole; duodenal ulcer; meta-analysis; omeprazole
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