title: Influence of the Alcohol Present in a Phytotherapic Tincture on Male Rat Lipid Profiles and Renal Function.
abstract: This study evaluated the influence of the alcohol present in a formulation of the antiophidic phytotherapic tincture, Específico-Pessôa, on rat blood biochemical and hematological parameters, and on organ histology. Three groups of rats were treated orally for 10, 15, or 30 days; one group received the tincture, the other received alcohol alone, and the third was a control group. The results of this study indicated that cholesterol levels were significantly increased after 10 days in the alcohol and tincture groups, although these decreased after 30 days in the tincture group. Triglyceride levels were significantly reduced after 15 days in the tincture group and after 30 days in the alcohol and tincture groups. A higher creatinine level was observed in the alcohol and tincture groups after 15 and 30 days. The uric acid levels in these groups were reduced at 10 and 30 days, although this metabolite was elevated at 15 days in the alcohol group. Hydropic multifocal degeneration with lymphohistiocytic infiltration and some polymorphonuclear cells was observed in the livers of rats treated with either the tincture or alcohol. These data demonstrate the importance of considering the potential actions of the alcohol present in pharmaceutical formulations.
authors.affiliation: Laboratory of Cellular Toxicology, State University of Western Paraná, Rua Universitária 1619, 85819110 Cascavel, PR, Brazil.
authors.forename: Fernanda Coleraus
authors.initials: FC
authors.lastname: Silva
authors.affiliation: Laboratory of Cellular Toxicology, State University of Western Paraná, Rua Universitária 1619, 85819110 Cascavel, PR, Brazil.
authors.forename: Juliete Gomes de Lara
authors.initials: JG
authors.lastname: de Souza
authors.affiliation: Laboratory of Cellular Toxicology, State University of Western Paraná, Rua Universitária 1619, 85819110 Cascavel, PR, Brazil.
authors.forename: Alana Meira
authors.initials: AM
authors.lastname: Reichert
authors.affiliation: Department of Veterinary Medicine, Dynamic Union of the Faculty Falls, 85852010 Foz do Iguaçu, PR, Brazil.
authors.forename: Renata Prestes
authors.initials: RP
authors.lastname: Antonangelo
authors.affiliation: Laboratory of Cellular Toxicology, State University of Western Paraná, Rua Universitária 1619, 85819110 Cascavel, PR, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Suzuki
authors.affiliation: Assistance Center in Toxicology (CEATOX), Hospital University of Western Paraná, Avenida Tancredo Neves 3224, 85806470 Cascavel, PR, Brazil.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Itinose
authors.affiliation: Laboratory of Cellular Toxicology, State University of Western Paraná, Rua Universitária 1619, 85819110 Cascavel, PR, Brazil.
authors.forename: Carla Brugin
authors.initials: CB
authors.lastname: Marek
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