title: Do fatty acids affect fetal programming?
abstract: BACKGROUND
  In this study discussed the primary and regulatory roles of fatty acids, and investigated the affects of fatty acids on metabolic programming.
  
  
  METHODS
  Review of the literature was carried out on three electronic databases to assess the roles of fatty acids in metabolic programming. All abstracts and full-text articles were examined, and the most relevant articles were selected for screening and inclusion in this review.
  
  
  RESULTS
  The mother's nutritional environment during fetal period has important effects on long term health. Fatty acids play a primary role in growth and development. Alterations in fatty acid intake in the fetal period may increase the risk of obesity and metabolic disorders in later life. Maternal fatty acid intakes during pregnancy and lactation are passed to the fetus and the newborn via the placenta and breast milk, respectively. Imbalances in fatty acid intake during the fetal period change the fatty acid composition of membrane phospholipids, which can cause structural and functional problems in cells. Additionally, the metabolic and neuroendocrine environments of the fetus and the newborn play key roles in the regulation of energy balance.
  
  
  CONCLUSIONS
  Imbalances in fatty acid intake during pregnancy and lactation may result in permanent changes in appetite control, neuroendocrine function and energy metabolism in the fetus, leading to metabolic programming. Further studies are needed to determine the role of fatty acid intake in metabolic programming.
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Eastern Mediterranean University, Famagusta, T.R. North Cyprus via Mersin 10, Turkey. seray.kabaran@emu.edu.tr.
authors.forename: Seray
authors.initials: S
authors.lastname: Kabaran
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Samanpazarı/Ankara, Turkey.
authors.forename: H Tanju
authors.initials: HT
authors.lastname: Besler
mesh_terms: D000818:Animals; D002657:Child Development; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D002149:Energy Intake; D004734:Energy Metabolism; D005227:Fatty Acids / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D047109:Fetal Development; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007774:Lactation; D050356:Lipid Metabolism; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D009490:Neurosecretory Systems / Q000254:growth & development / Q000378:metabolism; D011247:Pregnancy
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids
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