title: Cross-species transmission of CWD prions.
abstract: Prions cause fatal neurodegenerative diseases in humans and animals and can be transmitted zoonotically. Chronic wasting disease (CWD) is a highly transmissible prion disease of wild deer and elk that affects cervids over extensive regions of the United States and Canada. The risk of cross-species CWD transmission has been experimentally evaluated in a wide array of mammals, including non-human primates and mouse models expressing human cellular prion protein. Here we review the determinants of cross-species CWD transmission, and propose a model that may explain a structural barrier for CWD transmission to humans.
authors.affiliation: a Departments of Pathology and Medicine , UC San Diego , La Jolla , CA , USA.
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Kurt
authors.affiliation: a Departments of Pathology and Medicine , UC San Diego , La Jolla , CA , USA.|b Department of Pathology, Immunology, and Microbiology , UC Davis , Davis , CA , USA.
authors.forename: Christina J
authors.initials: CJ
authors.lastname: Sigurdson
mesh_terms: D000818:Animals; D006801:Humans; D011323:Primates; D011328:Prions / Q000737:chemistry / Q000378:metabolism / Q000472:pathogenicity; D013045:Species Specificity; D034081:Wasting Disease, Chronic / Q000635:transmission*; D015047:Zoonoses / Q000635:transmission
chemical_list: D011328:Prions
keywords: CJD; amyloid; chronic wasting disease; neurodegeneration; prion; zoonotic
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