title: Synthesis of Isomeric and Potent Impurities of the Triazole-Based Antifungal Drug Voriconazole.
abstract: We describe the synthesis of two positional isomers and a desfluoro impurity of Voriconazole starting with Friedel-Crafts acylation of mono- and difluorobenzene. These isomers are the crucial components in determining the quality of Voriconazole during its manufacturing from the key raw material, 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one. All the prepared impurities were characterized by IR, (1)H-NMR, (13)C-NMR, and mass spectral data.
authors.affiliation: Chemical Research and Development, APL Research Centre-II, Aurobindo Pharma Ltd., Survey No. 71 & 72, Indrakaran (V), Medak Dist.-502329, Andhra Pradesh, India; Department of Engineering chemistry, Andhra University College of Engineering (A), Andhra University, Visakhapatnam-530003, Andhra Pradesh, India.
authors.forename: Dhanraj T S S
authors.initials: DT
authors.lastname: Sundaram
authors.affiliation: Chemical Research and Development, APL Research Centre-II, Aurobindo Pharma Ltd., Survey No. 71 & 72, Indrakaran (V), Medak Dist.-502329, Andhra Pradesh, India.
authors.forename: Jayati
authors.initials: J
authors.lastname: Mitra
authors.affiliation: Chemical Research and Development, APL Research Centre-II, Aurobindo Pharma Ltd., Survey No. 71 & 72, Indrakaran (V), Medak Dist.-502329, Andhra Pradesh, India.
authors.forename: Aminul
authors.initials: A
authors.lastname: Islam
authors.affiliation: Chemical Research and Development, APL Research Centre-II, Aurobindo Pharma Ltd., Survey No. 71 & 72, Indrakaran (V), Medak Dist.-502329, Andhra Pradesh, India.
authors.forename: Koilpillai Joseph
authors.initials: KJ
authors.lastname: Prabahar
authors.affiliation: Department of Engineering chemistry, Andhra University College of Engineering (A), Andhra University, Visakhapatnam-530003, Andhra Pradesh, India.
authors.forename: Battula
authors.initials: B
authors.lastname: Venkateswara Rao
authors.affiliation: Department of Engineering chemistry, Andhra University College of Engineering (A), Andhra University, Visakhapatnam-530003, Andhra Pradesh, India.
authors.forename: Sanasi
authors.initials: S
authors.lastname: Paul Douglas
keywords: Chloroacetyl chloride; Impurity synthesis; Positional isomers; Voriconazole