title: WISP3 is highly expressed in a subset of colorectal carcinomas with a better prognosis.
abstract: Outlier genes with marked overexpression in subsets of cancers like ERBB2 have potential for the identification of gene classifiers and therapeutic targets for the appropriate subpopulation. In this study, using the cancer outlier profile analysis strategy, we identified WNT1-inducible-signaling pathway protein 3 (WISP3) as an outlier gene that is highly expressed in a subset of colorectal cancers (CRCs) from The Cancer Genome Atlas dataset. A meta-cancer outlier profile analysis and immunohistochemistry experiment to validate the outlier expression model of WISP3 in CRC was then performed. Our immunohistochemical results indicated that WISP3 was more frequently seen in the small tumors, and there was a significant association between its overexpression with a good prognosis. Furthermore, in the multivariable model, WISP3 outlier expression retained significance for overall survival. In summary, in this study, we identified an outlier gene WISP3 overexpressed in a subset of CRC having less aggressive characteristics and a better prognosis. We suggest WISP3 may provide more accurate and precise information regarding CRC population classification.
authors.affiliation: Department of Medicine, Huzhou Teachers College.
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Huzhou Teachers College, The First People's Hospital of Huzhou, Huzhou.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Huzhou Teachers College, The First People's Hospital of Huzhou, Huzhou.
authors.forename: Xinrong
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Huzhou Teachers College, The First People's Hospital of Huzhou, Huzhou.
authors.forename: Wenming
authors.initials: W
authors.lastname: Feng
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Huzhou Teachers College, The First People's Hospital of Huzhou, Huzhou.
authors.forename: Huihui
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Huzhou Teachers College, The First People's Hospital of Huzhou, Huzhou.
authors.forename: Chengwu
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Laboratory Diagnostic, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Anmei
authors.initials: A
authors.lastname: Deng
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Huzhou Teachers College, The First People's Hospital of Huzhou, Huzhou.
authors.forename: Ying
authors.initials: Y
authors.lastname: Bao
keywords: WISP3; microarray; outlier; prognosis; subtype
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