title: Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling.
abstract: Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This may be of particular importance in the context of immune receptors, such as the B cell receptor, where dysregulated signaling can result in autoimmunity and malignancy. Here, we discuss the role of the actin cytoskeleton in controlling receptor compartmentalization, dynamics, and clustering as a means to regulate receptor signaling through controlling the interactions with protein partners. We propose that the actin cytoskeleton is a point of integration for receptor cross talk through modulation of protein dynamics and clustering. We discuss the implication of this cross talk via the cytoskeleton for both ligand-induced and low-level constitutive (tonic) signaling necessary for immune cell survival.
authors.affiliation: Institute of Biomedicine, MediCity, University of Turku, 20520 Turku, Finland.
authors.forename: Pieta K
authors.initials: PK
authors.lastname: Mattila
authors.affiliation: Lymphocyte Interaction Laboratory, The Francis Crick Institute, Cancer Research UK, London WC2A 3LY, England, UK.
authors.forename: Facundo D
authors.initials: FD
authors.lastname: Batista
authors.affiliation: Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario M5T 1C6, Canada bebhinn.treanor@utoronto.ca.
authors.forename: Bebhinn
authors.initials: B
authors.lastname: Treanor
mesh_terms: D008841:Actin Cytoskeleton / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D006801:Humans; D021381:Protein Transport; D020239:Receptor Cross-Talk; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic
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