title: The potential of protein-nanomaterial interaction for advanced drug delivery.
abstract: Nanomaterials, like nanoparticles, micelles, nano-sheets, nanotubes and quantum dots, have great potentials in biomedical fields. However, their delivery is highly limited by the formation of protein corona upon interaction with endogenous proteins. This new identity, instead of nanomaterial itself, would be the real substance the organs and cells firstly encounter. Consequently, the behavior of nanomaterials in vivo is uncontrollable and some undesired effects may occur, like rapid clearance from blood stream; risk of capillary blockage; loss of targeting capacity; and potential toxicity. Therefore, protein-nanomaterial interaction is a great challenge for nanomaterial systems and should be inhibited. However, this interaction can also be used to functionalize nanomaterials by forming a selected protein corona. Unlike other decoration using exogenous molecules, nanomaterials functionalized by selected protein corona using endogenous proteins would have greater promise for clinical use. In this review, we aim to provide a comprehensive understanding of protein-nanomaterial interaction. Importantly, a discussion about how to use such interaction is launched and some possible applications of such interaction for advanced drug delivery are presented.
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark. Electronic address: qiangpengzz@scu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Peng
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark.
authors.forename: Huiling
authors.initials: H
authors.lastname: Mu
mesh_terms: D000327:Adsorption; D016503:Drug Delivery Systems; D049329:Nanostructures / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D011506:Proteins / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism
chemical_list: D011506:Proteins
keywords: Cysteine (PubChem CID: 5862); Folic acid (PubChem CID: 6037); Interface; Long-circulation; Nanoparticles; Nanotoxicity; Paclitaxel (PubChem CID: 44155032); Protein corona; SiO(2) (PubChem CID: 24261); Targeting delivery