title: Active topical therapy by "Furuta method" for effective pressure ulcer treatment: a retrospective study.
abstract: BACKGROUND
  We newly proposed that "Furuta method," a pharmacist intervention guidelines, is a topical ointment therapy that considers the physical properties and moist environment of wounds for pressure ulcer (PU) treatment. The aim of this multicenter retrospective study was to investigate the effectiveness of this method for PU.
  
  
  METHODS
  A total of 888 consecutive patients who underwent treatment for PU at 37 hospitals and five dispensing pharmacies in Japan between August 2010 and July 2014 were included in the study. Based on a survey on compliance to "Furuta method," single-blind allocation was conducted into compliance (n = 437) and non-compliance (n = 451) groups, followed by a retrospective data collection. The primary and secondary outcomes were the healing period and rates of unhealed wounds, respectively. Data was expressed as mean ± standard deviation. Two-sided log rank tests were used for between-group comparisons of PU progression, whereas Kaplan-Meier plots were used for comparison between groups. We performed rigorous adjustment for marked differences in baseline patient characteristics by propensity score (PS) matching.
  
  
  RESULTS
  After PS matching, patients were categorized as DESIGN-R d2 (n = 202), D3 (n = 130), D4 and 5 (n = 76), and DU (n = 76). In terms of the healing period, the patients in the compliance groups healed faster than those in the non-compliance groups in d2 (23.6 ± 36.8 vs. 32.2 ± 16.6 days; P < 0.001), D3 (46.8 ± 245.5 vs.137.3 ± 52.7 days; P < 0.001), and D4, 5 (122.5 ± 225.7 vs. 258.2 ± 292.7 days; P < 0.001). There were significantly lesser events of PU progression in the compliance group than in the non-compliance group (15 vs. 54; P = 0.003).
  
  
  CONCLUSIONS
  "Furuta method" is the new therapeutic strategy of PU, a pharmacist intervention guidelines, may possibly increase healing rates of PUs.
authors.affiliation: Department of Clinical Research and Development, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi 474-8511 Japan ; Department of Pharmacy, National Center for Geriatrics and Gerontology, Obu, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Furuta
authors.affiliation: Department of Pharmacy, National Center for Geriatrics and Gerontology, Obu, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Mizokami
authors.affiliation: Department of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sasaki
authors.affiliation: Department of Pharmacokinetics and Pharmacodynamics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Yasuhara
keywords: Furuta method; Pressure ulcer; Wound fixation; Wound physical property
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