title: Genomic Analyses Reveal Demographic History and Temperate Adaptation of the Newly Discovered Honey Bee Subspecies Apis mellifera sinisxinyuan n. ssp.
abstract: Studying the genetic signatures of climate-driven selection can produce insights into local adaptation and the potential impacts of climate change on populations. The honey bee (Apis mellifera) is an interesting species to study local adaptation because it originated in tropical/subtropical climatic regions and subsequently spread into temperate regions. However, little is known about the genetic basis of its adaptation to temperate climates. Here, we resequenced the whole genomes of ten individual bees from a newly discovered population in temperate China and downloaded resequenced data from 35 individuals from other populations. We found that the new population is an undescribed subspecies in the M-lineage of A. mellifera (Apis mellifera sinisxinyuan). Analyses of population history show that long-term global temperature has strongly influenced the demographic history of A. m. sinisxinyuan and its divergence from other subspecies. Further analyses comparing temperate and tropical populations identified several candidate genes related to fat body and the Hippo signaling pathway that are potentially involved in adaptation to temperate climates. Our results provide insights into the demographic history of the newly discovered A. m. sinisxinyuan, as well as the genetic basis of adaptation of A. mellifera to temperate climates at the genomic level. These findings will facilitate the selective breeding of A. mellifera to improve the survival of overwintering colonies.
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, China Key Laboratory of Pollinating Insect Biology, Ministry of Agriculture, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, China Key Laboratory of Pollinating Insect Biology, Ministry of Agriculture, Beijing, China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Novogene Bioinformatics Institute, Beijing, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Pan
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Huihua
authors.initials: H
authors.lastname: Wang
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Haikun
authors.initials: H
authors.lastname: Guo
authors.affiliation: Apiculture Management Center of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
authors.forename: Shidong
authors.initials: S
authors.lastname: Liu
authors.affiliation: Novogene Bioinformatics Institute, Beijing, China.
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Lu
authors.affiliation: Novogene Bioinformatics Institute, Beijing, China.
authors.forename: Shilin
authors.initials: S
authors.lastname: Tian
authors.affiliation: Novogene Bioinformatics Institute, Beijing, China Peking-Tsinghua Center for Life Sciences, Biodynamic Optical Imaging Center (BIOPIC) and School of Life Sciences, Peking University, Beijing, China.
authors.forename: Ruiqiang
authors.initials: R
authors.lastname: Li
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, China Key Laboratory of Pollinating Insect Biology, Ministry of Agriculture, Beijing, China shiweibri@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
mesh_terms: D000064:Acclimatization / Q000235:genetics*; D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D001516:Bees / Q000235:genetics*; D002681:China; D057231:Climate Change; D049810:Genetic Speciation; D005828:Genetics, Population; D023281:Genomics
keywords: Apis mellifera sinisxinyuan; adaptation; new subspecies; population history; temperate climates
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