title: Interstitial cystitis/painful bladder syndrome: diagnostic evaluation and therapeutic response in a private urogynecology unit.
abstract: BACKGROUND
  Interstitial cystitis/painful bladder syndrome (IC/PBS) is a spectrum of pelvic, bladder or urethral pain, as well as irritative voiding symptoms. The term interstitial cystitis (IC) is reserved for patients with typical cystoscopic features. Diagnosis and management of this syndrome may be difficult. The aim of this study was to describe endoscopic features and our experience on the treatment of this syndrome in Urodifem de Occidente S.C., a private urogynecology unit.
  
  
  METHODS
  Observational, retrospective analytic study of 25 treated patients from 33 with diagnosis of IC/PBS between January 2001 and March 2015. The diagnosis was done by clinical, cystoscopic and urodynamic approach. Treatment was based on bladder instillation of dymetilsulfoxido (DMSO), dexamethasone and heparin. Oral pentosan polysulphate was prescribed for at least 1 year.
  
  
  RESULTS
  Cystoscopic findings showed petechial hemorrhages in 32%, Hunner's lesions in 28%, glomerulations in 28% and bladder pain in absence of lesions in 12%. The basic treatment included one instillation once a week for 6 weeks, twice a month for 2 months and four monthly instillations. Three cases had complete remission of their symptoms, 21 had significant improvement and we have only one failure.
  
  
  CONCLUSIONS
  We recommend the combined use of DMSO instillation and pentosan polysulphate (PPS) in cases of IC/PBS.
authors.affiliation: Universidad de Guadalajara, Jalisco, México.
authors.forename: Oscar
authors.initials: O
authors.lastname: Flores-Carreras
authors.affiliation: Universidad de Guadalajara, Jalisco, México.
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: González-Ruiz
authors.affiliation: Universidad de Guadalajara, Jalisco, México.
authors.forename: Claudia J
authors.initials: CJ
authors.lastname: Martínez-Espinoza
authors.affiliation: Universidad de Guadalajara, Jalisco, México.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Monroy-Rodríguez
authors.affiliation: Universidad de Guadalajara, Jalisco, México.
authors.forename: Rocio M
authors.initials: RM
authors.lastname: Zaragoza-Torres
keywords: Interstitial Cystitis (IC); Interstitial Cystitis Problem Average Index (ICPI); Interstitial Cystitis Symptom Average Index (ICSI); dymethylsulfoxido (DMSO); painful bladder syndrome (PBS); pentosan polysulphate (PPS)
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