title: Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice.
abstract: The aim of this study was to investigate the possible protective effects of diallyl trisulfide (DATS) against naphthalene-induced oxidative and inflammatory damage in the livers and lungs of mice. Elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels showed significant hepatic damage after the challenge with 100 mg/kg naphthalene. Hepatic malondialdehyde (MDA) contents and the activity of myeloperoxidase (MPO) increased significantly, accompanying a decrease in the hepatic activity of total superoxide dismutase (SOD) and glutathione (GSH) levels after the naphthalene damage. In addition, the serum levels of nitric oxide (NO), tumor necrosis factor α (TNF-α), and interleukin 8 (IL-8) increased significantly in the groups damaged with naphthalene. The main parameters related to oxidative stress and inflammatory responses in the lungs, including the NO, MPO, and GSH contents, were determined, and the histopathological and immunohistochemical changes in the lung and liver tissues were also observed. In the DATS-treated groups, all of the oxidative and inflammatory damage in the serum, liver, and lung tissues were significantly prevented.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, PR China School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan, Shandong, PR China.
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.
authors.forename: Guangpu
authors.initials: G
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, PR China Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu, China uszxzhao@gmail.com.
authors.forename: Zhongxi
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu, China.
authors.forename: Shanzhong
authors.initials: S
authors.lastname: Li
authors.affiliation: Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Cai
authors.affiliation: Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu, China.
authors.forename: Jimin
authors.initials: J
authors.lastname: Cao
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D005978:Glutathione / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D009281:Naphthalenes / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D020011:Protective Agents / Q000494:pharmacology*; D013440:Sulfides / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000498:Allyl Compounds; D000975:Antioxidants; D009281:Naphthalenes; D020011:Protective Agents; D013440:Sulfides; C042577:diallyl trisulfide; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione
keywords: diallyl trisulfide; inflammatory; myeloperoxidase; naphthalene; nitric oxide; oxidative
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