title: Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction.
abstract: Predictive computational modelling in biomedical research offers the potential to integrate diverse data, uncover biological mechanisms that are not easily accessible through experimental methods and expose gaps in knowledge requiring further research. Recent developments in computing and diagnostic technologies have initiated the advancement of computational models in terms of complexity and specificity. Consequently, computational modelling can increasingly be utilised as enabling and complementing modality in the clinic-with medical decisions and interventions being personalised. Myocardial infarction and heart failure are amongst the leading causes of death globally despite optimal modern treatment. The development of novel MI therapies is challenging and may be greatly facilitated through predictive modelling. Here, we review the advances in patient-specific modelling of cardiac mechanics, distinguishing specificity in cardiac geometry, myofibre architecture and mechanical tissue properties. Thereafter, the focus narrows to the mechanics of the infarcted heart and treatment of myocardial infarction with particular attention on intramyocardial biomaterial delivery.
authors.affiliation: Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Private Bag X3, 7935, Observatory, South Africa.
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Sack
authors.affiliation: Cardiovascular Research Unit, MRC IUCHRU, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Observatory, South Africa.
authors.forename: Neil H
authors.initials: NH
authors.lastname: Davies
authors.affiliation: Department of Surgery, University of California at San Francisco, San Francisco, CA, USA.
authors.forename: Julius M
authors.initials: JM
authors.lastname: Guccione
authors.affiliation: Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Private Bag X3, 7935, Observatory, South Africa. thomas.franz@uct.ac.za.
authors.forename: Thomas
authors.initials: T
authors.lastname: Franz
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage*; D003198:Computer Simulation; D016503:Drug Delivery Systems; D006801:Humans; D007267:Injections; D009203:Myocardial Infarction / Q000188:drug therapy*; D066230:Patient-Specific Modeling; D051381:Rats
chemical_list: D001672:Biocompatible Materials
keywords: Cardiac disease; Computational model; Finite-element method; Heart failure; Ischaemic heart disease; Subject specific
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