title: Chemical Biology Probes from Advanced DNA-encoded Libraries.
abstract: The identification of bioactive compounds is a crucial step toward development of probes for chemical biology studies. Screening of DNA-encoded small molecule libraries (DELs) has emerged as a validated technology to interrogate vast chemical space. DELs consist of chimeric molecules composed of a low-molecular weight compound that is conjugated to a DNA identifier tag. They are screened as pooled libraries using selection to identify "hits." Screening of DELs has identified numerous bioactive compounds. Some of these molecules were instrumental in gaining a deeper understanding of biological systems. One of the main challenges in the field is the development of synthesis methodology for DELs.
authors.affiliation: Faculty of Chemistry and Chemical Biology, Technical University of Dortmund , Otto-Hahn-Straße 6, D-44227 Dortmund, Germany.
authors.forename: Hazem
authors.initials: H
authors.lastname: Salamon
authors.affiliation: Faculty of Chemistry and Chemical Biology, Technical University of Dortmund , Otto-Hahn-Straße 6, D-44227 Dortmund, Germany.
authors.forename: Mateja
authors.initials: M
authors.lastname: Klika Škopić
authors.affiliation: Faculty of Chemistry and Chemical Biology, Technical University of Dortmund , Otto-Hahn-Straße 6, D-44227 Dortmund, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Jung
authors.affiliation: Faculty of Chemistry and Chemical Biology, Technical University of Dortmund , Otto-Hahn-Straße 6, D-44227 Dortmund, Germany.
authors.forename: Olivia
authors.initials: O
authors.lastname: Bugain
authors.affiliation: Faculty of Chemistry and Chemical Biology, Technical University of Dortmund , Otto-Hahn-Straße 6, D-44227 Dortmund, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Brunschweiger
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry* / Q000494:pharmacology; D055808:Drug Discovery / Q000379:methods*; D015723:Gene Library; D006801:Humans; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D054852:Small Molecule Libraries; D004247:DNA