title: Trimetazidine hydrochloride as a new treatment for patients with peripheral vascular disease--an exploratory trial.
abstract: OBJECTIVE
  To evaluate the therapeutic effect of trimetazidine hydrochloride in peripheral vascular disease patients who had Rutherford classification grade 2-3.
  
  
  METHODS
  72 patients with Rutherford classification grade 2-3 in peripheral vascular were recruited successfully, they were randomly assigned to control group (35 cases) and trimetazidine group (37 cases), patients in control group received conventional treatment and trimetazidine group received conventional treatment plus trimetazidine hydrochloride for 6 months. Their ankle brachial index (ABI), maximum walking distance, pain onset time and the maximum walking time were compared before and after the treatment.
  
  
  RESULTS
  After 6 months' treatment, the ABI, maximum walking distance, pain onset time and the maximum walking time in two groups were both improved of when compared with before treatment (p < 0.05). The maximum walking distance, pain onset time and the maximum walking time in trimetazidine group were improved better than control (p < 0.05) while no evident improvement in ABI between the 2 groups (p > 0.05).
  
  
  CONCLUSIONS
  Conventional therapy plus trimetazidine hydrochloride could significantly improve the clinical symptoms of patients with Rutherford classification Grade 2-3 in peripheral vascular.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Logistical College of Chinese People's Armed Police Forces, Tianjin, Tianjin, China. yshunchu@163.com.
authors.forename: Y-S
authors.initials: YS
authors.lastname: Chu
authors.forename: D-X
authors.initials: DX
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: T-M
authors.initials: TM
authors.lastname: Jiang
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*; D016138:Walking
chemical_list: D014665:Vasodilator Agents; D014292:Trimetazidine