title: Iron-Catalyzed Allylic Amination Directly from Allylic Alcohols.
abstract: Allylic amination, directly from alcohols, has been demonstrated without any Lewis acid activators using an efficient and regiospecific molecular iron catalyst. Various amines and alcohols were employed and the reaction proceeded through the oxidation/reduction (redox) pathway. A direct one-step synthesis of common drugs, such as cinnarizine and nafetifine, was exhibited from cinnamyl alcohol that produced water as side product.
authors.affiliation: Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, India.
authors.forename: Balakumar
authors.initials: B
authors.lastname: Emayavaramban
authors.affiliation: Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, India.
authors.forename: Moumita
authors.initials: M
authors.lastname: Roy
authors.affiliation: Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, India. basker@iitk.ac.in.
authors.forename: Basker
authors.initials: B
authors.lastname: Sundararaju
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis; D000586:Amination; D000588:Amines / Q000138:chemical synthesis; D002384:Catalysis; D007501:Iron / Q000737:chemistry*; D010084:Oxidation-Reduction; D020005:Propanols / Q000737:chemistry*
chemical_list: D000498:Allyl Compounds; D000588:Amines; D020005:Propanols; C006463:allyl alcohol; D007501:Iron; C020722:cinnamyl alcohol
keywords: alcohols; allylic compounds; amination; hydrogen borrowing; iron