title: [Related factors of optical coherence tomography detected in-stent heterogonous neointima].
abstract: OBJECTIVE
  To explore the related factors of optical coherence tomography (OCT) detected in-stent heterogeneous neointimal in coronary stents.
  
  
  METHODS
  A total of 143 cases of coronary heart disease patients with OCT detected in-stent neointimal hyperplasia in Fuwai hospital from September 2009 to April 2012 were included in this study and patients data were retrospectively analyzed. Patients were divided into heterogeneous intima group(26 cases) and homogeneous intima group(117 cases)according to neointimal characteristics. Clinical features and OCT characteristics of the 2 groups were compared and binary logistic regression analysis was performed to analyze the risk factors of in-stent heterogonous neointimal hyperplasia.
  
  
  RESULTS
  Compared to homogeneous intima group, patients in heterogeneous intima group had significantly higher cholesterol level ((5.31±1.11)mmol/L vs.(4.70±0.94)mmol/L, P=0.005), low-density lipoprotein cholesterol level ((2.57±0.87)mmol/L vs.(2.29±0.46)mmol/L, P=0.021) and triglyceride level (2.12(1.82-2.87)mmol/L vs. 1.90(1.73-2.11)mmol/L, P=0.015). Moreover, the percent of percutaneous coronary intervention (PCI) because of acute coronary syndrome (23.1%(6/26) vs. 6.8%(8/117), P=0.022) and the thin cap neoatheroma (5.8%(28/481)vs. 3.9%(89/2 276), P=0.043) were also significantly higher in heterogeneous intima group than in homogeneous intima group. Binary logistic regression analysis showed that low-density lipoprotein cholesterol (OR=2.74, 95%CI 1.04-7.24, P=0.042), triglyceride (OR=2.88, 95%CI 1.05-7.89, P=0.040), PCI for acute coronary syndrome (OR=12.74, 95%CI 2.69-60.49, P=0.001), and cerebrovascular disease (OR=13.09, 95%CI 2.16-79.53, P=0.005) were risk factors for in-stent heterogenous intima. Time post stent implantation was protective factor for in-stent heterogenous intima (OR=0.63, 95%CI 0.42-0.96, P=0.033).
  
  
  CONCLUSIONS
  OCT detected heterogeneous intima is correlated with level of blood lipid, PCI for acute coronary syndrome and history of cerebrovascular disease, and it may lead to unstable intima.
authors.affiliation: Coronary Heart Disease Center, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Dewei
authors.initials: D
authors.lastname: Wu
authors.forename: Mengyue
authors.initials: M
authors.lastname: Yu
authors.forename: Yuejin
authors.initials: Y
authors.lastname: Yang
authors.forename: Shubin
authors.initials: S
authors.lastname: Qiao
authors.forename: Jie
authors.initials: J
authors.lastname: Qian
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Song
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Wu
mesh_terms: D054058:Acute Coronary Syndrome; D003324:Coronary Artery Disease; D006801:Humans; D006965:Hyperplasia; D058426:Neointima; D062645:Percutaneous Coronary Intervention; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents; D041623:Tomography, Optical Coherence; D017539:Tunica Intima