title: MiR-608 rs4919510 is associated with prognosis of hepatocellular carcinoma.
abstract: Single nucleotide polymorphisms (SNPs) within microRNAs (miRNAs) are considered potential markers for risk and prognosis of various cancers. In the current study, we aimed to determine whether miR-608 rs4919510 affected hepatocellular carcinoma (HCC) prognosis. We genotyped rs4919510 using DNA from blood samples of 362 HCC patients receiving surgical resection of HCC tumor. Associations between rs4919510 and overall survival (OS) and demographic characteristics and clinical features were estimated using the Cox proportional hazards model. Results showed that HCC patients who carried the rs4919510 CC genotype had a significantly longer OS compared to those who carried the GG genotype (P = 0.013, hazard ratio [HR] = 0.600, 95 % confidence interval [CI] 0.402-0.897) and the CG + GG genotype (P = 0.033, HR = 0.681, 95 % CI 0.479-0.970) in univariate analysis. Similar results were obtained in multivariate analysis. Further stratification analysis indicated that rs4919510 was significantly associated with OS in patients who were satisfied with one of the following criteria: male gender, HbsAg-positive, α-fetoprotein (AFP)-positive, tumor size >5 cm, cirrhosis, solitary tumor, I + II pTNM stage, or no tumor capsule. Finally, a significantly higher frequency of rs4919510 CC genotype was observed in patients with cirrhosis (22.9 %, 55/240) than those without cirrhosis (14.0 %, 17/121) (P = 0.047). In conclusion, our results illustrated the potential role of miR-608 rs4919510 as a prognostic marker for HCC patients undergoing surgical resection of the tumor.
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Xiao-Pin
authors.initials: XP
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.|Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.|Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.|Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
authors.forename: Guopeng
authors.initials: G
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Xubo
authors.initials: X
authors.lastname: Chen
authors.affiliation: Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Qianyi
authors.initials: Q
authors.lastname: Xiao
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Zhuqing
authors.initials: Z
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Lu-Yao
authors.initials: LY
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Pengyin
authors.initials: P
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Dong-Lin
authors.initials: DL
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Hui-Xing
authors.initials: HX
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.
authors.forename: Hexige
authors.initials: H
authors.lastname: Saiyin
authors.affiliation: Qidong Liver Cancer Institute, Qidong People's Hospital, Qidong, Jiangsu, China.
authors.forename: Tao-Yang
authors.initials: TY
authors.lastname: Chen
authors.affiliation: Qidong Liver Cancer Institute, Qidong People's Hospital, Qidong, Jiangsu, China.
authors.forename: Pei-Xin
authors.initials: PX
authors.lastname: Lu
authors.affiliation: Qidong Liver Cancer Institute, Qidong People's Hospital, Qidong, Jiangsu, China.
authors.forename: Neng-Jin
authors.initials: NJ
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Yu
authors.affiliation: Center for Genomic Cancer Research, NorthShore University HealthSystem, Evanston, IL, USA.
authors.forename: Carly
authors.initials: C
authors.lastname: Conran
authors.affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
authors.forename: Jielin
authors.initials: J
authors.lastname: Sun
authors.affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.|Center for Genomic Cancer Research, NorthShore University HealthSystem, Evanston, IL, USA.
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.|Center for genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China.|Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.|Center for Genomic Cancer Research, NorthShore University HealthSystem, Evanston, IL, USA.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China.|Institute of Biomedical Science, Fudan University, Shanghai, China.
authors.forename: Long
authors.initials: L
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Songhu Rd., Shanghai, 200438, China. dekejiang@fudan.edu.cn.|Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China. dekejiang@fudan.edu.cn.|Center for genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China. dekejiang@fudan.edu.cn.|Center for Genetic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China. dekejiang@fudan.edu.cn.|Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA. dekejiang@fudan.edu.cn.|Center for Genomic Cancer Research, NorthShore University HealthSystem, Evanston, IL, USA. dekejiang@fudan.edu.cn.|Pritzker School of Medicine, University of Chicago, Chicago, IL, USA. dekejiang@fudan.edu.cn.
authors.forename: De-Ke
authors.initials: DK
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C000591804:MIRN608 microRNA, human; D035683:MicroRNAs
keywords: Genetic polymorphism; Hepatocellular carcinoma; Survival; miRNA
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