title: Barrett Esophagus: Evolving Concepts in Diagnosis and Neoplastic Progression.
abstract: Surgical pathologists need to answer 2 questions when evaluating biopsies from the distal esophagus or gastroesophageal junction in patients with a history of gastroesophageal reflux disease: Are the findings consistent with Barrett esophagus? and Is there any evidence of dysplasia? Pathologists should be well informed about the controversy around the definition of Barrett esophagus and the common pitfalls that lead to a false-positive diagnosis of Barrett esophagus or Barrett esophagus-associated dysplasia. A concise description of distinct morphologic types of dysplasia in Barrett esophagus and a summary of recent data on the natural history of BE are provided in this review.
authors.affiliation: Department of Pathology, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Lisovsky
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address: ASrivastava@partners.org.
authors.forename: Amitabh
authors.initials: A
authors.lastname: Srivastava
keywords: Adenocarcinoma; Barrett’s esophagus; Cancer; Dysplasia; Esophagus; Metaplasia; Prognosis