title: Clear cell carcinomas of the ovary: a mono-institutional study of 73 cases in China with an analysis of the prognostic significance of clinicopathological parameters and IMP3 expression.
abstract: BACKGROUND
  Ovarian clear cell carcinoma (CCC) is an uncommon subtype of ovarian epithelial tumor. The prognostic significance of its clinicopathological parameters is discordant, with the exception of stage as the adverse prognostic factor. The present study aimed to evaluate the prognostic significance of its clinicopathological characteristics and the expression of IMP3 (Insulin-like growth factor-II mRNA-binding protein 3, IMP3 or IGF2BP3) in Chinese patients with primary pure CCC.
  
  
  METHODS
  We collected clinicopathological data from 73 cases with a minimum of 5 years of follow-up and evaluated the expression of IMP3 by immunohistochemistry.
  
  
  RESULTS
  In total, 49.3 % of the patients were in stage I. Advanced stages were closely related to poor prognosis of disease-free survival (DFS) and overall survival (OS) (P < 0.005). Patients with CCC coexisting with endometriosis tended to be younger and to have unilateral involvement but did not exhibit differences in prognosis compared with patients with CCC without endometriosis. Other histological features such as growth pattern, mitosis, and necrosis did not have prognostic significance. IMP3 was positive in 63 % of patients (46 of 73 cases); Thus, positive expression of IMP3 is an adverse prognostic marker in terms of OS (P = 0.012), even in stage I patients (P = 0.038).
  
  
  CONCLUSIONS
  The present study demonstrates that IMP3 expression is a prognostic marker, with the exception of stage. IMP3 represents a biomarker of unfavorable prognosis even in stage I patients.
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. br_fdcc@163.com.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. br_fdcc@163.com.
authors.forename: Rui
authors.initials: R
authors.lastname: Bi
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. shen_xuxia@126.com.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. shen_xuxia@126.com.
authors.forename: Xuxia
authors.initials: X
authors.lastname: Shen
authors.affiliation: Psycho-Oncology Research & Training (CePORT), School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong. lilianzhangweiwei@163.com.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. chengyufan2009@163.com.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. chengyufan2009@163.com.
authors.forename: Yufan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. 15121012375@163.com.|Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. 15121012375@163.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. caixu66@163.com.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. caixu66@163.com.
authors.forename: Xu
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. yangwt2000@163.com.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. yangwt2000@163.com.
authors.forename: Wentao
authors.initials: W
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D000077216:Carcinoma, Ovarian Epithelial; D002681:China; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D016601:RNA-Binding Proteins / Q000032:analysis*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C498780:IGF2BP3 protein, human; D016601:RNA-Binding Proteins
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