title: Immune Cells and Inflammation in Diabetic Nephropathy.
abstract: Diabetic nephropathy (DN) is a serious complication of diabetes. At its core, DN is a metabolic disorder which can also manifest itself in terms of local inflammation in the kidneys. Such inflammation can then drive the classical markers of fibrosis and structural remodeling. As a result, resolution of immune-mediated inflammation is critical towards achieving a cure for DN. Many immune cells play a part in DN, including key members of both the innate and adaptive immune systems. While these cells were classically understood to primarily function against pathogen insult, it has also become increasingly clear that they also serve a major role as internal sensors of damage. In fact, damage sensing may serve as the impetus for much of the inflammation that occurs in DN, in a vicious positive feedback cycle. Although direct targeting of these proinflammatory cells may be difficult, new approaches that focus on their metabolic profiles may be able to alleviate DN significantly, especially since dysregulation of the local metabolic environment may well be responsible for triggering inflammation to begin with. In this review, the authors consider the metabolic profile of several relevant immune types and discuss their respective roles.
authors.affiliation: College of Arts and Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
authors.forename: Zihan
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Nephrology, Advanced Institute for Medical Sciences, Second Hospital, Dalian Medical University, Dalian 116023, China; Department of Nephrology and Basic Science Laboratory, Fujian Medical University, Fuzhou 350002, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zheng
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D007668:Kidney / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009393:Nephritis / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism
chemical_list: D018836:Inflammation Mediators
references.citation: J Am Coll Cardiol. 2014 Apr 22;63(15):1556-66
references.pmid: 24361318
references.citation: Am J Clin Exp Immunol. 2013 Oct 16;2(3):195-207
references.pmid: 24179728
references.citation: Trends Immunol. 2014 Oct 22;35(12):591-596
references.pmid: 25457838
references.citation: PLoS One. 2013;8(11):e79084
references.pmid: 24260158
references.citation: J Diabetes Res. 2013;2013:979702
references.pmid: 23691527
references.citation: Biochem Biophys Res Commun. 2013 Jan 4;430(1):375-80
references.pmid: 23159616
references.citation: J Clin Med. 2015 May 19;4(5):1010-24
references.pmid: 26239462
references.citation: Nat Immunol. 2011 Mar;12(3):231-8
references.pmid: 21240265
references.citation: Apoptosis. 2015 Apr;20(4):466-80
references.pmid: 25577277
references.citation: J Am Soc Nephrol. 2011 Feb;22(2):317-26
references.pmid: 21289217
references.citation: Eur J Immunol. 2012 Nov;42(11):2875-80
references.pmid: 22806568
references.citation: Diabetes. 2010 Nov;59(11):2916-27
references.pmid: 20699418
references.citation: Diabetes. 2012 Apr;61(4):897-907
references.pmid: 22357963
references.citation: Transl Res. 2015 Oct;166(4):375-83
references.pmid: 26001596
references.citation: Immunity. 2015 Jan 20;42(1):41-54
references.pmid: 25607458
references.citation: Cell. 2006 Sep 22;126(6):1121-33
references.pmid: 16990136
references.citation: N Engl J Med. 1993 Jun 10;328(23):1676-85
references.pmid: 8487827
references.citation: J Infect Dis. 2015 Aug 1;212(3):484-94
references.pmid: 25657256
references.citation: Immunity. 2015 Jun 16;42(6):1062-74
references.pmid: 26084024
references.citation: Immunol Res. 2012 Apr;52(1-2):20-33
references.pmid: 22392051
references.citation: J Immunol. 2014 Oct 1;193(7):3409-16
references.pmid: 25156361
references.citation: Sci Rep. 2014;4:4146
references.pmid: 24553452
references.citation: Nat Commun. 2015;6:6931
references.pmid: 25959047
references.citation: Free Radic Biol Med. 2011 Nov 1;51(9):1686-96
references.pmid: 21856412
references.citation: Biochem Biophys Res Commun. 2014 Jan 17;443(3):828-33
references.pmid: 24342619
references.citation: J Biol Chem. 2011 Sep 23;286(38):33084-94
references.pmid: 21784849
references.citation: Immunol Rev. 2014 Nov;262(1):74-84
references.pmid: 25319328
references.citation: Metabolism. 2015 Oct;64(10):1316-23
references.pmid: 26282733
references.citation: Brain Res. 2011 Feb 10;1373:189-94
references.pmid: 21138740
references.citation: Gut. 2014 Aug;63(8):1300-12
references.pmid: 24082036
references.citation: Front Immunol. 2014 Dec 16;5:630
references.pmid: 25566245
references.citation: Nat Commun. 2014;5:4575
references.pmid: 25099390
references.citation: Front Immunol. 2015 Jun 02;6:260
references.pmid: 26082777
references.citation: J Biol Chem. 2015 Aug 14;290(33):20499-510
references.pmid: 26100632
references.citation: Science. 2009 Jun 5;324(5932):1334-8
references.pmid: 19498172
references.citation: Immunol Rev. 2011 Sep;243(1):152-62
references.pmid: 21884174
references.citation: J Exp Med. 2013 Dec 16;210(13):2903-19
references.pmid: 24277153
references.citation: J Clin Invest. 2013 Nov;123(11):4888-99
references.pmid: 24135141
references.citation: Biochem Biophys Res Commun. 2015 Mar 13;458(3):650-5
references.pmid: 25684181
references.citation: Diabetes Care. 2005 Jan;28(1):164-76
references.pmid: 15616252
references.citation: J Clin Invest. 2015 Apr;125(4):1579-90
references.pmid: 25798621
references.citation: Cancer Res. 2010 Oct 1;70(19):7465-75
references.pmid: 20841473
references.citation: J Immunol. 2012 Oct 1;189(7):3669-80
references.pmid: 22933625
references.citation: Cancer Immunol Res. 2015 Jun;3(6):620-30
references.pmid: 25701326
references.citation: Proc Natl Acad Sci U S A. 2011 May 31;108(22):9220-5
references.pmid: 21576463
references.citation: Microbes Infect. 2014 Oct;16(10):822-32
references.pmid: 25449753
references.citation: Nat Immunol. 2015 Jan;16(1):118-28
references.pmid: 25401424
references.citation: Nat Rev Nephrol. 2011 Jun;7(6):327-40
references.pmid: 21537349
references.citation: Immunity. 2015 Mar 17;42(3):419-30
references.pmid: 25786174
references.citation: J Immunol. 2008 Apr 1;180(7):4476-86
references.pmid: 18354169
references.citation: Nat Commun. 2015;6:6676
references.pmid: 25813085
references.citation: J Pharmacol Sci. 2015 Feb;127(2):181-9
references.pmid: 25727955
references.citation: Trends Immunol. 2013 May;34(5):224-33
references.pmid: 23352728
references.citation: N Engl J Med. 1999 Oct 7;341(15):1127-33
references.pmid: 10511612
references.citation: J Immunol. 2015 Jul 1;195(1):317-28
references.pmid: 25987744
references.citation: J Exp Med. 2013 Oct 21;210(11):2181-90
references.pmid: 24101376
references.citation: J Immunol. 2013 Dec 1;191(11):5695-701
references.pmid: 24133167
references.citation: Kidney Int Suppl. 2009 Dec;(114):S3-11
references.pmid: 19946325
references.citation: J Immunol. 2015 Apr 15;194(8):3873-82
references.pmid: 25780040
references.citation: Diabetes. 2011 Feb;60(2):590-601
references.pmid: 20980457
references.citation: Nat Immunol. 2013 May;14(5):500-8
references.pmid: 23525088
references.citation: Blood. 2008 Nov 1;112(9):3723-34
references.pmid: 18694997
references.citation: J Immunol. 2014 Sep 15;193(6):3013-22
references.pmid: 25108023
references.citation: Nature. 2015 Jun 25;522(7557):474-7
references.pmid: 25970251
references.citation: Nature. 2013 Apr 25;496(7446):513-7
references.pmid: 23467085
references.citation: Dis Model Mech. 2015 Oct 1;8(10):1311-21
references.pmid: 26398934
references.citation: Immunity. 2015 Apr 21;42(4):744-55
references.pmid: 25862092
references.citation: Hum Mol Genet. 2009 Feb 1;18(3):482-96
references.pmid: 18996917
references.citation: J Cardiovasc Pharmacol. 2008 Oct;52(4):324-32
references.pmid: 18791464
references.citation: J Immunol. 2014 Jun 1;192(11):5118-29
references.pmid: 24778448
references.citation: J Immunol. 2013 Jan 15;190(2):774-83
references.pmid: 23241884
references.citation: Curr Opin Nephrol Hypertens. 2015 May;24(3):245-51
references.pmid: 25887903
references.citation: J Immunol. 2011 Mar 15;186(6):3299-303
references.pmid: 21317389
references.citation: Cell Cycle. 2015;14(14):2340-54
references.pmid: 26131730
references.citation: Adv Clin Chem. 2012;56:55-74
references.pmid: 22397028
references.citation: J Exp Med. 2014 Jan 13;211(1):89-104
references.pmid: 24395888
references.citation: Front Immunol. 2015 Jan 22;5:683
references.pmid: 25657646
references.citation: Cell Metab. 2013 Aug 6;18(2):251-64
references.pmid: 23931756
references.citation: Semin Nephrol. 2012 Sep;32(5):452-62
references.pmid: 23062986
references.citation: J Pathol. 2015 Jan;235(1):79-89
references.pmid: 25158055
references.citation: J Immunol. 2013 Jan 1;190(1):58-65
references.pmid: 23203924
references.citation: Nephron Exp Nephrol. 2011;119(4):e83-90
references.pmid: 22133868
references.citation: J Immunol. 1998 Oct 1;161(7):3431-7
references.pmid: 9759861
references.citation: Methods Mol Biol. 2011;720:67-79
references.pmid: 21318867
references.citation: Mol Cell Biol. 2009 Mar;29(6):1575-91
references.pmid: 19114551
references.citation: J Am Soc Nephrol. 2010 Nov;21(11):1819-34
references.pmid: 20864689
references.citation: J Biol Chem. 2011 Sep 16;286(37):32162-9
references.pmid: 21795715
references.citation: Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14532-7
references.pmid: 22912406
references.citation: EMBO J. 2001 Jul 16;20(14):3760-70
references.pmid: 11447117
references.citation: Trends Immunol. 2006 Aug;27(8):352-7
references.pmid: 16807108
references.citation: Cell. 2011 Sep 2;146(5):772-84
references.pmid: 21871655
references.citation: Am J Nephrol. 2015;41(4-5):337-44
references.pmid: 26067713
references.citation: Nature. 2015 Feb 26;518(7540):547-51
references.pmid: 25470051
references.citation: Diabetes Res Clin Pract. 2011 Dec;94(3):311-21
references.pmid: 22079683
references.citation: Nature. 2013 Apr 25;496(7446):518-22
references.pmid: 23467095
references.citation: Diabetol Metab Syndr. 2015 May 24;7:48
references.pmid: 26023321
references.citation: J Allergy Clin Immunol. 2015 Mar;135(3):781-91.e3
references.pmid: 25441291
references.citation: J Lipid Res. 2009 Oct;50(10):2004-13
references.pmid: 19436068
references.citation: Kidney Int. 2013 Sep;84(3):545-54
references.pmid: 23615507
references.citation: Diabetes. 2009 Aug;58(8):1780-8
references.pmid: 19509023
references.citation: Nature. 2013 Apr 11;496(7444):238-42
references.pmid: 23535595
references.citation: Nature. 2015 Jul 9;523(7559):221-5
references.pmid: 25924064
references.citation: Cell Signal. 2014 Feb;26(2):192-7
references.pmid: 24219909
references.citation: Biochem Biophys Res Commun. 1995 Jul 17;212(2):550-6
references.pmid: 7626069
references.citation: Biomed Res Int. 2014;2014:837421
references.pmid: 25054148
references.citation: Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1357-65
references.pmid: 25838428
references.citation: Epigenomics. 2013 Apr;5(2):195-204
references.pmid: 23566096
references.citation: J Exp Med. 2013 Jul 1;210(7):1447-62
references.pmid: 23797094