title: Durable Control and Overall Survival Benefit with Focal Reirradiation in Cervical Cancer.
abstract: Local recurrence following definitive chemoradiation in cervical cancer ranges from 5-18%. Currently, there are limited options available for patients recurring in para-aortic or iliac lymph nodes. We present two cases of reirradiation for non-central recurrences with intensity-modulated radiotherapy (IMRT). Both patients achieved a complete response with manageable short-term toxicities and no late adverse effects with a follow-up of over one year and three years after reirradiation. While further follow-up is needed, IMRT is a feasible and safe option in cervical cancer patients with recurrent in-field failures involving the lymph nodes.
authors.affiliation: Department of Radiation Oncology, University of Colorado School of Medicine.
authors.forename: Arya
authors.initials: A
authors.lastname: Amini
authors.affiliation: Department of Radiation Oncology, University of Colorado School of Medicine.
authors.forename: Whitney
authors.initials: W
authors.lastname: Sumner
authors.affiliation: Department of Radiation Oncology, University of Colorado School of Medicine.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Fisher
keywords: cervical cancer; imrt; intensity-modulated radiotherapy; local control; lymph node recurrence; non-central; recurrence; reirradiation
references.citation: Radiat Oncol. 2013 Apr 05;8:79
references.pmid: 23561250
references.citation: J Clin Oncol. 2004 Mar 1;22(5):872-80
references.pmid: 14990643
references.citation: Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1396-403
references.pmid: 19581056
references.citation: CA Cancer J Clin. 2015 Mar;65(2):87-108
references.pmid: 25651787
references.citation: Gynecol Oncol. 1993 Jan;48(1):23-31
references.pmid: 8423018
references.citation: Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1129-39
references.pmid: 16414206
references.citation: Cancer. 2005 Sep 15;104(6):1296-303
references.pmid: 16078260
references.citation: Eur J Surg Oncol. 2015 Aug;41(8):975-85
references.pmid: 25922209