title: Neuroprotective effect of fucoidan from Turbinaria decurrens in MPTP intoxicated Parkinsonic mice.
abstract: Fucoidan is one of the dominant sulfated polysaccharide which was extracted from the brown seaweed Turbinaria decurrens. In the behavioral study mice treated with fucoidan showed better response than the MPTP treated mice. Antioxidants and dopamine level has been increased in the fucoidan treated mice when compared to MPTP induced mice. In Immunohistochemistry, the increase of TH positive cells in the fucoidan treated group is correlated with the TH protein levels in substantia nigra and corpus striatum. The increase is greater than the content of dopamine and DOPAC, which may be explained that the dopaminergic terminals are more sensitive to MPTP toxicity and therefore are more severely damaged than the dopaminergic cell bodies. In immunoblotting TH and DAT was used, both the antibodies expression in MPTP was reduced and reversed in other groups. From the results it was conformed that the fucoidan has a neuroprotective effect without any side effects.
authors.affiliation: Sri Paramakalyani Centre of Excellence in Environmental Science, Manonmaniam Sundarnar University, Alwarkurichi, Tamilnadu, India. Electronic address: smeenakshi85@gmail.com.
authors.forename: Selvaraju
authors.initials: S
authors.lastname: Meenakshi
authors.affiliation: Department of Microbiology, School of Life Sciences, Vels University, Chennai, Tamilnadu, India.
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Umayaparvathi
authors.affiliation: Department of Zoology, Sri K.G.S Arts College, Srivaikuntam, Thoothukudi (dt), Tamilnadu, India.
authors.forename: Ravichandran
authors.initials: R
authors.lastname: Saravanan
authors.affiliation: Department of Biochemistry, Annamalai University, Chidambaram, Tamilnadu, India.
authors.forename: Thamilarasan
authors.initials: T
authors.lastname: Manivasagam
authors.affiliation: Former Dean & Director, CAS in Marine Biology, Annamalai University, Parangipettai, Tamilnadu, India.
authors.forename: Thangavel
authors.initials: T
authors.lastname: Balasubramanian
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D020267:MPTP Poisoning / Q000378:metabolism* / Q000473:pathology* / Q000517:prevention & control; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology* / Q000517:prevention & control; D011134:Polysaccharides / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D011134:Polysaccharides; C007789:fucoidan; D004298:Dopamine
keywords: Brown seaweed; MPTP; Neuroprotective; Parkinson disease; Turbinaria decurrens