title: Vitamin C ameliorates high dose Dexmedetomidine induced liver injury.
abstract: BACKGROUND
  We investigated whether vitamin C has protective effects on rat liver tissue treated with different dexmedetomidine doses.
  
  
  METHODS
  Thirty five wistar albino rats were randomly divided into 5 groups (Control (0.9% NaCl intraperitoneally (i.p.), Dexmedetomidine 5 μg.kg(-1) (i.p.), Dexmedetomidine 5 μg.kg(-1) i.p. plus Vitamin C (100 mg.kg(-1)), Dexmedetomidine 10 μg.kg(-1) i.p. and Dexmedetomidine 10 μg.kg(-1) i.p. plus Vitamin C (100 mg.kg(-1)). Histopathological liver injury, superoxide dismutase (SOD) activity and tissue Malondialdehyde levels were investigated.
  
  
  RESULTS
  Hepatocyte degeneration was significantly higher in D10 group than those in other study groups (p < 0.0001, p = 0.002, p < 0.0001, p = 0.005, respectively). Similarly, liver tissue sinusoidal dilatation and hepatocyte necrosis were significantly higher in D10 group than those in other groups (p < 0.0001, p < 0.0001, p = 0.002, p < 0.0001 and p < 0.0001, p = 0.046, p < 0.0001 and p = 0.002, respectively). Tissue MDA levels in D10 group were significantly higher than those in control, D5+Vit C and D10+Vit C groups (p = 0.028, p = 0.004, p = 0.031, respectively). SOD enzyme activity in D10 group was significantly lower than in control, D5+Vit C and D10+Vit C groups (p < 0.0001, p = 0.023 and p = 0.031, respectively).
  
  
  CONCLUSIONS
  High dose dexmedetomidine can induce hepatic injury and oxidative stress in rats while pre-treatment with vitamin C may be effective in protecting liver tissue against this newly recognized undesirable dexmedetomidine effect (Tab. 2, Fig. 5, Ref. 30).
authors.forename: M
authors.initials: M
authors.lastname: Arslan
authors.forename: S C
authors.initials: SC
authors.lastname: Sezen
authors.forename: H C
authors.initials: HC
authors.lastname: Turgut
authors.forename: M
authors.initials: M
authors.lastname: Kocabiyik
authors.forename: H
authors.initials: H
authors.lastname: Arpaci
authors.forename: F M
authors.initials: FM
authors.lastname: Comu
authors.forename: L
authors.initials: L
authors.lastname: Ozturk
authors.forename: M
authors.initials: M
authors.lastname: Kavutcu
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D020011:Protective Agents; D020927:Dexmedetomidine; D001205:Ascorbic Acid
keywords: Dexmedetomidine; MDA; SOD; liver histopathology; rat.; vitamin C