title: [Determination of contact angle of pharmaceutical excipients and regulating effect of surfactants on their wettability].
abstract: To study the effects of surfactants on wettability of excipients, the contact angles of six types of surfactants on the surface of two common excipients and mixture of three surfactants with excipients were measured using hypsometry method. The results demonstrated that contact angle of water on the surface of excipients was associated with hydrophilcity of excipients. Contact angle was lowered with increase in hydrophilic groups of excipient molecules. The sequence of contact angle from small to large was starch < sodium benzoate < polyvinylpyrrolidone < sodium carboxymethylcellulose < sodium alginate < chitosan < hydroxypropyl methyl cellulose <magnesium stearate. In addition, surfactants both in droplets and mixed in excipients significantly reduced the contact angle of excipients, and their abilities to lower contact angle varied. The results of the present study offer a guideline in the formulation design of tablets.
authors.forename: Dong-dong
authors.initials: DD
authors.lastname: Hua
authors.forename: He-ran
authors.initials: HR
authors.lastname: Li
authors.forename: Bai-xue
authors.initials: BX
authors.lastname: Yang
authors.forename: Li-na
authors.initials: LN
authors.lastname: Song
authors.forename: Tiao-tiao
authors.initials: TT
authors.lastname: Liu
authors.forename: Yu-tang
authors.initials: YT
authors.lastname: Cong
authors.forename: San-ming
authors.initials: SM
authors.lastname: Li
mesh_terms: D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D013501:Surface-Active Agents / Q000737:chemistry*; D013607:Tablets; D014867:Water; D017155:Wettability
chemical_list: D005079:Excipients; D013501:Surface-Active Agents; D013607:Tablets; D014867:Water