title: Screening of Panamanian Plants for Cosmetic Properties, and HPLC-Based Identification of Constituents with Antioxidant and UV-B Protecting Activities.
abstract: A library of 600 taxonomically diverse Panamanian plant extracts was screened for DPPH scavenging and UV-B protective activities, and the methanolic extracts of Mosquitoxylum jamaicense, Combretum cacoucia, and Casearia commersionia were submitted to HPLC-based activity profiling. The compounds located in the active time windows were isolated and identified as gallic acid derivatives and flavonoids. Gallic acid methyl ester (3) and digallic acid derivatives (2, 6) showed the highest DPPH scavenging activity (<10 μg/mL), while protocatechuic acid (7) and isoquercitrin (10) exhibited the highest UV-B protective properties.
authors.affiliation: Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 40, CH-4056 Basel, Switzerland.
authors.forename: Niels
authors.initials: N
authors.lastname: Guldbrandsen
authors.affiliation: Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 40, CH-4056 Basel, Switzerland.
authors.forename: Maria
authors.initials: M
authors.lastname: De Mieri
authors.affiliation: CIFLORPAN, College of Pharmacy, University of Panama, Apartado 0824-00172, Panama, Republic of Panama.
authors.forename: Mahabir
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Laboratory of Cell Proliferation & Ageing, Institute of Biosciences & Applications, NCSR "Demokritos", 15310, Athens, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Liakou
authors.affiliation: Laboratory of Cell Proliferation & Ageing, Institute of Biosciences & Applications, NCSR "Demokritos", 15310, Athens, Greece.
authors.forename: Harris
authors.initials: H
authors.lastname: Pratsinis
authors.affiliation: Laboratory of Cell Proliferation & Ageing, Institute of Biosciences & Applications, NCSR "Demokritos", 15310, Athens, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kletsas
authors.affiliation: Korres S.A. Natural Products, 57th Athens-Lamia National Road, 32011, Inofyta, Greece; Department of Pharmacognosy & Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Zografou, 15771, Greece.
authors.forename: Eliza
authors.initials: E
authors.lastname: Chaita
authors.affiliation: Department of Pharmacognosy & Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Zografou, 15771, Greece.
authors.forename: Nektarios
authors.initials: N
authors.lastname: Aligiannis
authors.affiliation: Department of Pharmacognosy & Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Zografou, 15771, Greece.
authors.forename: Alexios-Leandros
authors.initials: AL
authors.lastname: Skaltsounis
authors.affiliation: Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 40, CH-4056 Basel, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Hamburger
keywords: DPPH scavenging; HPLC-based activity profiling; Panamanian plant extract; UV-B protection
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