title: Pseudoverticin B, a novel geldanamycin analog obtained as new cell cycle inhibitor from Streptomyces pseudoverticillus YN17707.
abstract: Pseudoverticin B (1), a novel naturally occurring geldanamycin analog with cell cycle inhibitory activity, was isolated from the fermentation broth of Streptomyces pseudoverticillus YN17707, together with the known ansamycin antibiotic, hydroquinone geldanamycin (2), through bioassay-guided fractionation procedures. The structure of compound 1 was elucidated by spectroscopic methods, being characterized by an ansa bridge, same as that in geldanamycin and a novel hydroquinone-derived moiety. Compounds 1 and 2 arrested the cell cycle of tsFT210 cells at the G0/G1 phase with the minimum inhibitory concentration values of 10.1 and 20.2 μmolL(-1), respectively.
authors.affiliation: a Beijing Institute of Biomedicine , Beijing 100091 , China.
authors.forename: Wen-Xin
authors.initials: WX
authors.lastname: Li
authors.affiliation: a Beijing Institute of Biomedicine , Beijing 100091 , China.
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.affiliation: b State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing 100850 , China.
authors.forename: Cheng-Bin
authors.initials: CB
authors.lastname: Cui
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D059447:Cell Cycle Checkpoints; D047029:Lactams, Macrocyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D016227:Benzoquinones; D047029:Lactams, Macrocyclic; C000613229:pseudoverticin B; C001277:geldanamycin
keywords: Pseudoverticin B; Streptomyces pseudoverticillus; cell cycle inhibitor; geldanamycin; hydroquinone geldanamycin