title: The crucial role and regulations of miRNAs in zebrafish development.
abstract: To comprehend the events during developmental biology, fundamental knowledge about the basic machinery of regulation is a prerequisite. MicroRNA (miRNAs) act as regulators in most of the biological processes and recently, it has been concluded that miRNAs can act as modulatory factors even during developmental process from lower to higher animal. Zebrafish, because of its favorable attributes like tiny size, transparent embryo, and rapid external embryonic development, has gained a preferable status among all other available experimental animal models. Currently, zebrafish is being utilized for experimental studies related to stem cells, regenerative molecular medicine as well drug discovery. Therefore, it is important to understand precisely about the various miRNAs that controls developmental biology of this vertebrate model. In here, we have discussed about the miRNA-controlled zebrafish developmental stages with a special emphasis on different miRNA families such as miR-430, miR-200, and miR-133. Moreover, we have also reviewed the role of various miRNAs during embryonic and vascular development stages of zebrafish. In addition, efforts have been made to summarize the involvement of miRNAs in the development of different body parts such as the brain, eye, heart, muscle, and fin, etc. In each section, we have tried to fulfill the gaps of zebrafish developmental biology with the help of available knowledge of miRNA research. We hope that precise knowledge about the miRNA-regulated developmental stages of zebrafish may further help the researchers to efficiently utilize this vertebrate model for experimental purpose.
authors.affiliation: Aquaculture Research Unit, Department of Zoology, Vidyasagar University, Midnapore, 721102, West Bengal, India.|Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, South Korea.
authors.forename: Manojit
authors.initials: M
authors.lastname: Bhattacharya
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, South Korea.
authors.forename: Ashish Ranjan
authors.initials: AR
authors.lastname: Sharma
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, South Korea.|Amity Institute of Nanotechnology, Amity University Uttar Pradesh, Noida, 201313, India.
authors.forename: Garima
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Aquaculture Research Unit, Department of Zoology, Vidyasagar University, Midnapore, 721102, West Bengal, India.
authors.forename: Bidhan Chandra
authors.initials: BC
authors.lastname: Patra
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, South Korea.
authors.forename: Ju-Suk
authors.initials: JS
authors.lastname: Nam
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, South Korea. drchiranjib@yahoo.com.|Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida, 201306, India. drchiranjib@yahoo.com.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, South Korea. totalhip@hallym.ac.kr.|Department of Orthopedic Surgery, Hallym University Hospital-College of Medicine, Chuncheon-si, Gangwon-do, 200-704, Republic of Korea. totalhip@hallym.ac.kr.
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics; D015027:Zebrafish / Q000033:anatomy & histology / Q000196:embryology* / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: Developmental biology; Vertebrate model; Zebrafish development; miRNA
references.citation: J Comp Neurol. 2001 Sep 17;438(2):173-90
references.pmid: 11536187
references.citation: PLoS One. 2009;4(4):e5279
references.pmid: 19390574
references.citation: Nat Genet. 2011 Mar;43(3):204-11
references.pmid: 21258340
references.citation: Nucleic Acids Res. 2004 Dec 07;32(21):6284-91
references.pmid: 15585662
references.citation: Curr Biol. 2005 Apr 26;15(8):743-9
references.pmid: 15854907
references.citation: Nature. 1995 Jun 22;375(6533):678-81
references.pmid: 7791900
references.citation: EMBO J. 2004 Oct 13;23(20):4051-60
references.pmid: 15372072
references.citation: Cell. 2005 Nov 18;123(4):621-9
references.pmid: 16271385
references.citation: FEBS Lett. 2005 Oct 31;579(26):5911-22
references.pmid: 16111679
references.citation: Curr Opin Genet Dev. 2005 Aug;15(4):410-5
references.pmid: 15979303
references.citation: Annu Rev Microbiol. 2010;64:123-41
references.pmid: 20477536
references.citation: Neuron. 2008 Jan 10;57(1):41-55
references.pmid: 18184563
references.citation: PLoS One. 2014 Feb 06;9(2):e88086
references.pmid: 24516585
references.citation: Science. 2001 Aug 3;293(5531):834-8
references.pmid: 11452083
references.citation: Nat Commun. 2013;4:1978
references.pmid: 23748970
references.citation: Genome Biol. 2007;8(8):R173
references.pmid: 17711588
references.citation: J Comp Neurol. 2005 Apr 4;484(2):224-33
references.pmid: 15736231
references.citation: Biochem Biophys Res Commun. 2009 Apr 17;381(4):688-93
references.pmid: 19254693
references.citation: Genes Dev. 2001 Oct 15;15(20):2654-9
references.pmid: 11641272
references.citation: Science. 2005 Jul 8;309(5732):310-1
references.pmid: 15919954
references.citation: J Cell Mol Med. 2009 Jan;13(1):24-38
references.pmid: 19175698
references.citation: Blood. 2012 Mar 15;119(11):2679-87
references.pmid: 22207734
references.citation: RNA Biol. 2015;12(6):615-27
references.pmid: 25833418
references.citation: Methods Cell Biol. 2010;100:xiii
references.pmid: 21111211
references.citation: Curr Biol. 2006 Nov 7;16(21):2135-42
references.pmid: 17084698
references.citation: Nat Neurosci. 2008 Jun;11(6):641-8
references.pmid: 18454145
references.citation: Annu Rev Cell Dev Biol. 2007;23:175-205
references.pmid: 17506695
references.citation: Nat Rev Mol Cell Biol. 2009 Feb;10(2):126-39
references.pmid: 19165215
references.citation: Nature. 2013 Mar 21;495(7441):333-8
references.pmid: 23446348
references.citation: Nucleic Acids Res. 2004 Jan 1;32(Database issue):D109-11
references.pmid: 14681370
references.citation: Genome Biol. 2004;5(3):R13
references.pmid: 15003116
references.citation: Science. 2004 Jan 2;303(5654):95-8
references.pmid: 14631048
references.citation: Dev Dyn. 1995 Jul;203(3):253-310
references.pmid: 8589427
references.citation: Cell. 2003 Dec 26;115(7):787-98
references.pmid: 14697198
references.citation: Neural Dev. 2010 Oct 01;5:25
references.pmid: 20920300
references.citation: BMC Evol Biol. 2014 Sep 25;14:196
references.pmid: 25253178
references.citation: Nat Rev Mol Cell Biol. 2005 May;6(5):376-85
references.pmid: 15852042
references.citation: J Cell Sci. 2014 May 15;127(Pt 10):2291-301
references.pmid: 24634509
references.citation: Science. 2005 May 6;308(5723):833-8
references.pmid: 15774722
references.citation: Curr Opin Neurobiol. 2009 Oct;19(5):461-70
references.pmid: 19846291
references.citation: Gene Expr Patterns. 2009 Jun;9(5):364-70
references.pmid: 19602392
references.citation: Nat Rev Genet. 2007 May;8(5):353-67
references.pmid: 17440532
references.citation: Nat Genet. 2008 Mar;40(3):290-8
references.pmid: 18264099
references.citation: Science. 2001 Nov 9;294(5545):1290-1
references.pmid: 11701913
references.citation: Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2851-7
references.pmid: 24982181
references.citation: Genes Dev. 2004 Mar 1;18(5):504-11
references.pmid: 15014042
references.citation: Dev Cell. 2008 Aug;15(2):261-71
references.pmid: 18694565
references.citation: Methods Mol Biol. 2015;1214:129-50
references.pmid: 25468601
references.citation: Development. 2013 Jul;140(13):2755-64
references.pmid: 23698347
references.citation: Methods Mol Biol. 2009;546:227-40
references.pmid: 19378107
references.citation: Cold Spring Harb Symp Quant Biol. 2006;71:195-203
references.pmid: 17381297
references.citation: Nucleic Acids Res. 2008 Jan;36(Database issue):D165-9
references.pmid: 18029362
references.citation: Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17830-5
references.pmid: 19004786
references.citation: Dev Cell. 2008 Aug;15(2):272-84
references.pmid: 18694566
references.citation: Dev Dyn. 2011 Apr;240(4):808-19
references.pmid: 21360794
references.citation: Nucleic Acids Res. 2013 Apr;41(8):4470-80
references.pmid: 23470996
references.citation: BMC Genomics. 2009 Apr 27;10:195
references.pmid: 19397817
references.citation: Science. 2001 Aug 31;293(5535):1670-3
references.pmid: 11533493
references.citation: Nucleic Acids Res. 2006 May 12;34(9):2558-69
references.pmid: 16698962
references.citation: J Exp Biol. 2009 Jun;212(Pt 12):1781-93
references.pmid: 19482995
references.citation: Genome Res. 2004 Oct;14(10A):1902-10
references.pmid: 15364901
references.citation: Genome Biol. 2004;5(9):R68
references.pmid: 15345052
references.citation: J Cell Sci. 2007 Sep 1;120(Pt 17):3045-52
references.pmid: 17715156
references.citation: PLoS One. 2012;7(11):e50536
references.pmid: 23226307
references.citation: Dev Cell. 2003 Aug;5(2):351-8
references.pmid: 12919684
references.citation: Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18384-9
references.pmid: 19015519
references.citation: PLoS One. 2013 Jun 05;8(6):e65170
references.pmid: 23755189
references.citation: Genes Dev. 2005 Feb 15;19(4):489-501
references.pmid: 15713842
references.citation: Mol Cells. 2008 Sep 30;26(3):308-13
references.pmid: 18728384
references.citation: Invest Ophthalmol Vis Sci. 2007 Feb;48(2):509-15
references.pmid: 17251443
references.citation: RNA. 2006 Jul;12(7):1161-7
references.pmid: 16738409
references.citation: J Am Soc Hypertens. 2015 Mar;9(3):221-34
references.pmid: 25660363
references.citation: Development. 2011 Apr;138(7):1409-19
references.pmid: 21385766
references.citation: Genes Dev. 2003 Dec 15;17(24):3011-6
references.pmid: 14681208
references.citation: Genes Dev. 2005 Jun 1;19(11):1288-93
references.pmid: 15937218
references.citation: Science. 2002 Dec 13;298(5601):2188-90
references.pmid: 12481136
references.citation: Front Bioeng Biotechnol. 2016 Jul 14;4:60
references.pmid: 27471727
references.citation: Trends Biochem Sci. 2007 Apr;32(4):189-97
references.pmid: 17350266
references.citation: RNA. 2003 Feb;9(2):175-9
references.pmid: 12554859
references.citation: Nat Struct Mol Biol. 2011 Oct 07;18(11):1218-26
references.pmid: 21984184
references.citation: Curr Opin Otolaryngol Head Neck Surg. 2010 Oct;18(5):459-65
references.pmid: 20717030
references.citation: Nature. 2013 Apr 25;496(7446):498-503
references.pmid: 23594743
references.citation: BMC Dev Biol. 2010 Jan 06;10:1
references.pmid: 20053268
references.citation: Cell Tissue Res. 2015 Jan;359(1):179-85
references.pmid: 24865244
references.citation: Cell. 2003 Oct 17;115(2):209-16
references.pmid: 14567918
references.citation: Genes Dev. 2004 Dec 15;18(24):3016-27
references.pmid: 15574589
references.citation: Nat Genet. 2006 Feb;38(2):228-33
references.pmid: 16380711
references.citation: Genes Dev. 2008 Mar 15;22(6):728-33
references.pmid: 18347091
references.citation: Gerontology. 2010;56(2):231-40
references.pmid: 19923791
references.citation: Nat Genet. 2007 Feb;39(2):259-63
references.pmid: 17220889
references.citation: Zebrafish. 2014 Dec;11(6):499-508
references.pmid: 25110965
references.citation: BMC Genomics. 2008 May 29;9:253
references.pmid: 18510755
references.citation: J Neurosci. 2010 Mar 3;30(9):3254-63
references.pmid: 20203184
references.citation: Nat Rev Mol Cell Biol. 2008 Jan;9(1):22-32
references.pmid: 18073770
references.citation: Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14385-9
references.pmid: 16983084
references.citation: J Neurosci. 2002 Aug 1;22(15):6570-7
references.pmid: 12151536
references.citation: Dev Biol. 2012 May 15;365(2):319-27
references.pmid: 22374218
references.citation: PLoS One. 2012;7(12):e52588
references.pmid: 23285103
references.citation: Science. 2006 Apr 7;312(5770):75-9
references.pmid: 16484454
references.citation: Eur J Neurosci. 2011 May;33(9):1587-97
references.pmid: 21447094
references.citation: Am J Respir Crit Care Med. 2009 Oct 15;180(8):713-9
references.pmid: 19644046
references.citation: Circ Res. 2011 Jan 21;108(2):201-9
references.pmid: 21148433
references.citation: Cell. 2009 Jan 23;136(2):215-33
references.pmid: 19167326
references.citation: Biochem Biophys Res Commun. 2009 Mar 13;380(3):437-41
references.pmid: 19284987
references.citation: Nat Cell Biol. 2010 Nov;12(11):1101-7
references.pmid: 20935637
references.citation: Circ Res. 2012 Mar 16;110(6):870-4
references.pmid: 22427324
references.citation: J Cell Biol. 2009 Apr 6;185(1):115-27
references.pmid: 19332888
references.citation: J Comp Neurol. 1996 Jan 29;365(1):113-28
references.pmid: 8821445
references.citation: Nature. 2004 Nov 11;432(7014):231-5
references.pmid: 15531879
references.citation: Cold Spring Harb Symp Quant Biol. 2002;67:49-56
references.pmid: 12858523
references.citation: Curr Pathobiol Rep. 2015;3(1):81-88
references.pmid: 25722956
references.citation: Nature. 2001 Jan 18;409(6818):363-6
references.pmid: 11201747
references.citation: Genes Dev. 2005 Dec 1;19(23):2837-48
references.pmid: 16287716
references.citation: Nature. 2000 Nov 2;408(6808):86-9
references.pmid: 11081512
references.citation: Trends Genet. 2006 Mar;22(3):165-73
references.pmid: 16446010
references.citation: Development. 2011 Aug;138(16):3421-30
references.pmid: 21752928
references.citation: RNA. 2005 Mar;11(3):241-7
references.pmid: 15701730
references.citation: Cells. 2014 Jul 22;3(3):724-50
references.pmid: 25055156
references.citation: Genes Dev. 2009 Mar 1;23(5):619-32
references.pmid: 19240126
references.citation: J Cell Sci. 2006 Dec 15;119(Pt 24):5169-77
references.pmid: 17158919
references.citation: Dev Cell. 2012 Feb 14;22(2):418-29
references.pmid: 22340502
references.citation: Zebrafish. 2010 Dec;7(4):343-8
references.pmid: 21158564