title: [Associated risk factors of ischemic events for spontaneous cervical artery dissection].
abstract: OBJECTIVE
  This study sought to identify risk factors of ischemic events and predictors of outcome for spontaneous cervical artery dissection (sCAD).
  
  
  METHODS
  One hundred and sixty one patients diagnosed as sCAD were classified as patients with (n=77) and without (n=84) cerebral ischemia. Demographics, vascular risk factors and imaging features were compared between the two groups. Multivariate Cox regression analysis was performed to identify predictors of primary end-point events (all cause stroke and death) at follow-up.
  
  
  RESULTS
  Patients with cerebral ischemia had a higher prevelence of hypertension and diabetes mellitus (62.3% vs 41.7%, 14.3% vs 6.2%, P<0.05). Patients with cerebral ischemia were more likely to present with stenosis (61.0% vs 23.8%, P<0.001) and less likely to present with aneurysmal dilatation (19.5% vs 44.0%, P<0.001) and double lumen (22.1% vs 38.1%, P<0.05). There was significant positive association of diabetes mellitus (odds ratio 3.095; 95% confidence interval, 1.273 to 7.524, P=0.013) and stenosis (odds ratio 4.335, 95% confidence interval, 2.123 to 8.854, P<0.001), and an inverse association of aneurysmal dilatation (odds ratio 0.429, 95% confidence interval, 0.198 to 0.930, P=0.032) with occurrence of ischemic events in patients with sCAD. At a mean follow-up of 16.0 months, overall incidence of primary end-point was 9.3% (n=15). Cox regression analysis showed cerebral ischemia at onset, arterial occlusion, obesity or overweightness were significant predictors of the primary endpoint.
  
  
  CONCLUSIONS
  This study confirms that diabetes mellitus and arterial stenosis are risk factors of ischemic events for sCAD patients. Cerebral ischemia at onset, arterial occlusion, obesity or overweightness are predictors of primary endpoint at follow-up.
authors.affiliation: Department of Neurology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Department of Neurology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Neurology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Huadong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China; Email: liujuan961@163.com.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
mesh_terms: D000784:Aortic Dissection; D001158:Arteries; D002545:Brain Ischemia; D002544:Cerebral Infarction; D003920:Diabetes Mellitus; D006801:Humans; D006973:Hypertension; D015994:Incidence; D009333:Neck; D016017:Odds Ratio; D012307:Risk Factors; D020521:Stroke