title: Pregnancy as a Window to Future Cardiovascular Health: Design and Implementation of the nuMoM2b Heart Health Study.
abstract: The National Institute of Child Health and Human Development's Nulliparous Pregnancy Outcomes Study-Monitoring Mothers-to-Be (nuMoM2b) Heart Health Study (HHS) was designed to investigate the relationships between adverse pregnancy outcomes and modifiable risk factors for cardiovascular disease. The ongoing nuMoM2b-HHS, which started in 2013, is a prospective follow-up of the nuMoM2b cohort, which included 10,038 women recruited between 2010 and 2013 from 8 centers across the United States who were initially observed over the course of their first pregnancies. In this report, we detail the design and study procedures of the nuMoM2b-HHS. Women in the pregnancy cohort who consented to be contacted for participation in future studies were approached at 6-month intervals to ascertain health information and to maintain ongoing contact. Two to 5 years after completion of the pregnancy documented in the nuMoM2b, women in the nuMoM2b-HHS were invited to an in-person study visit. During this visit, they completed psychosocial and medical history questionnaires and had clinical measurements and biological specimens obtained. A subcohort of participants who had objective assessments of sleep-disordered breathing during pregnancy were asked to repeat this investigation. This unique prospective observational study includes a large, geographically and ethnically diverse cohort, rich depth of phenotypic information about adverse pregnancy outcomes, and clinical data and biospecimens from early in the index pregnancy onward. Data obtained from this cohort will provide mechanistic and clinical insights into how data on a first pregnancy can provide information about the potential development of subsequent risk factors for cardiovascular disease.
authors.forename: David M
authors.initials: DM
authors.lastname: Haas
authors.forename: Deborah B
authors.initials: DB
authors.lastname: Ehrenthal
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Koch
authors.forename: Janet M
authors.initials: JM
authors.lastname: Catov
authors.forename: Shannon E
authors.initials: SE
authors.lastname: Barnes
authors.forename: Francesca
authors.initials: F
authors.lastname: Facco
authors.forename: Corette B
authors.initials: CB
authors.lastname: Parker
authors.forename: Brian M
authors.initials: BM
authors.lastname: Mercer
authors.forename: C Noel
authors.initials: CN
authors.lastname: Bairey-Merz
authors.forename: Robert M
authors.initials: RM
authors.lastname: Silver
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Wapner
authors.forename: Hyagriv N
authors.initials: HN
authors.lastname: Simhan
authors.forename: Matthew K
authors.initials: MK
authors.lastname: Hoffman
authors.forename: William A
authors.initials: WA
authors.lastname: Grobman
authors.forename: Philip
authors.initials: P
authors.lastname: Greenland
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Wing
authors.forename: George R
authors.initials: GR
authors.lastname: Saade
authors.forename: Samuel
authors.initials: S
authors.lastname: Parry
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Zee
authors.forename: Uma M
authors.initials: UM
authors.lastname: Reddy
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Pemberton
authors.forename: Dale R
authors.initials: DR
authors.lastname: Burwen
mesh_terms: D000293:Adolescent; D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006305:Health Status Indicators; D006801:Humans; D011159:Population Surveillance / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012107:Research Design; D018570:Risk Assessment; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology
keywords: cardiovascular disease; cohort study; heart health; methods; pregnancy; women's health
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