title: Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals.
abstract: In an immune response, CD4(+) T cells expand into effector T cells and then contract to survive as long-lived memory cells. To identify age-associated defects in memory cell formation, we profiled activated CD4(+) T cells and found an increased induction of the ATPase CD39 with age. CD39(+) CD4(+) T cells resembled effector T cells with signs of metabolic stress and high susceptibility to undergo apoptosis. Pharmacological inhibition of ATPase activity dampened effector cell differentiation and improved survival, suggesting that CD39 activity influences T cell fate. Individuals carrying a low-expressing CD39 variant responded better to vaccination with an increase in vaccine-specific memory T cells. Increased inducibility of CD39 after activation may contribute to the impaired vaccine response with age.
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Fengqin
authors.initials: F
authors.lastname: Fang
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Mingcan
authors.initials: M
authors.lastname: Yu
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Mary M
authors.initials: MM
authors.lastname: Cavanagh
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Hutter Saunders
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Qi
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Zhongde
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Sabine
authors.initials: S
authors.lastname: Le Saux
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA.
authors.forename: William
authors.initials: W
authors.lastname: Sultan
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Emerson
authors.initials: E
authors.lastname: Turgano
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Cornelia L
authors.initials: CL
authors.lastname: Dekker
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Tian
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: Weyand
authors.affiliation: Departments of Medicine, Pediatrics, and Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304, USA. Electronic address: jgoronzy@stanford.edu.
authors.forename: Jörg J
authors.initials: JJ
authors.lastname: Goronzy
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D015703:Antigens, CD / Q000378:metabolism*; D017209:Apoptosis; D001081:Apyrase / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D049109:Cell Proliferation; D002470:Cell Survival; D002999:Clone Cells; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008875:Middle Aged; D013312:Stress, Physiological; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D000251:Adenosine Triphosphatases; C027201:ectoATPase; D001081:Apyrase; C067869:CD39 antigen
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