title: Insular Volume Reduction in Patients with Social Anxiety Disorder.
abstract: Despite the fact that social anxiety disorder (SAD) is highly prevalent, there have been only a few structural imaging studies. Moreover, most of them reported about a volume reduction in amygdale, which plays a key role in the neural function of SAD. Insula is another region of interest. Its hyperactivity in regard to processing negative emotional information or interoceptive awareness has been detected in patients with SAD. Referring to these studies, we hypothesized that insular volumes might reduce in patients with SAD and made a comparison of insular volumes between 13 patients with SAD and 18 healthy controls with matched age and gender using voxel-based morphometry. As a result, we found a significant volume reduction in insula in the SAD group. Our results suggest that the patients with SAD might have an insular volume reduction apart from amygdala. Since insula plays a critical role in the pathology of SAD, more attention should be paid not only to functional study but also morphometrical study of insula.
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Graduate School of Medical Sciences, Nagoya City University , Nagoya , Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Kawaguchi
authors.affiliation: Department of Psychiatry, Faculty of Medicine, University of Tsukuba , Ibaraki , Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nemoto
authors.affiliation: Department of Psychiatry, Keio University , Tokyo , Japan.
authors.forename: Shutaro
authors.initials: S
authors.lastname: Nakaaki
authors.affiliation: Department of Radiology, Toyota-Kai Medical Corporation, Kariya Toyota General Hospital , Kariya , Japan.
authors.forename: Takatsune
authors.initials: T
authors.lastname: Kawaguchi
authors.affiliation: Department of Radiology, Nagoya City University Hospital , Nagoya , Japan.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Kan
authors.affiliation: Department of Radiology, Nagoya City University Hospital , Nagoya , Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Arai
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Graduate School of Medical Sciences, Nagoya City University , Nagoya , Japan.
authors.forename: Nao
authors.initials: N
authors.lastname: Shiraishi
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Graduate School of Medical Sciences, Nagoya City University , Nagoya , Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Hashimoto
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Graduate School of Medical Sciences, Nagoya City University , Nagoya , Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Akechi
keywords: insula; magnetic resonance imaging; social anxiety disorder; voxel-based morphometry
references.citation: Neuroimage. 2012 Jan 16;59(2):1879-87
references.pmid: 21920442
references.citation: Arch Gen Psychiatry. 2005 Jun;62(6):593-602
references.pmid: 15939837
references.citation: Biol Psychiatry. 2004 Dec 15;56(12):921-30
references.pmid: 15601601
references.citation: Mod Probl Pharmacopsychiatry. 1987;22:141-73
references.pmid: 2885745
references.citation: Neuroimage. 2010 Oct 1;52(4):1549-58
references.pmid: 20470894
references.citation: J Psychiatry Neurosci. 2009 Jul;34(4):296-302
references.pmid: 19568481
references.citation: Science. 2003 Oct 10;302(5643):290-2
references.pmid: 14551436
references.citation: Arch Gen Psychiatry. 2000 Feb;57(2):191-2
references.pmid: 10665624
references.citation: Psychiatry Clin Neurosci. 2006 Jun;60(3):332-9
references.pmid: 16732750
references.citation: Biol Psychol. 2012 Jan;89(1):273-6
references.pmid: 22027088
references.citation: Biol Psychiatry. 2005 May 1;57(9):975-81
references.pmid: 15860337
references.citation: Schizophr Res. 2010 Nov;123(2-3):93-104
references.pmid: 20832997
references.citation: Neuroimage. 2003 Jul;19(3):1233-9
references.pmid: 12880848
references.citation: Biol Psychiatry. 2006 Aug 15;60(4):383-7
references.pmid: 16780813
references.citation: Neuron. 2013 Feb 20;77(4):624-38
references.pmid: 23439117
references.citation: J Psychiatry Neurosci. 2010 Mar;35(2):126-31
references.pmid: 20184810
references.citation: Eur Psychiatry. 2007 Sep;22(6):387-94
references.pmid: 17416488
references.citation: Neuroimage. 2002 Jun;16(2):331-48
references.pmid: 12030820
references.citation: Metab Brain Dis. 2012 Sep;27(3):299-309
references.pmid: 22527992
references.citation: Depress Anxiety. 2008;25(6):496-505
references.pmid: 17595018
references.citation: Brain Res. 2011 May 4;1388:167-77
references.pmid: 21402057
references.citation: Neuropsychologia. 1971 Mar;9(1):97-113
references.pmid: 5146491
references.citation: Neuroimage. 2009 Apr 15;45(3):976-83
references.pmid: 19280711
references.citation: Biol Psychiatry. 2004 Aug 15;56(4):225-32
references.pmid: 15312809
references.citation: Biol Psychol. 2010 May;84(2):304-12
references.pmid: 20227458
references.citation: Psychiatr Danub. 2013 Jun;25(2):108-14
references.pmid: 23793273
references.citation: Brain Res. 2007 Apr 27;1143:169-82
references.pmid: 17306235
references.citation: Biol Psychiatry. 2013 Jan 1;73(1):75-84
references.pmid: 22748614
references.citation: J Neurosci. 2007 Feb 28;27(9):2349-56
references.pmid: 17329432
references.citation: Nat Neurosci. 2004 Feb;7(2):189-95
references.pmid: 14730305
references.citation: Neuroimage. 2009 Nov 1;48(2):371-80
references.pmid: 19559801
references.citation: J Clin Psychopharmacol. 2007 Oct;27(5):531-4
references.pmid: 17873700
references.citation: Behav Res Ther. 1998 Apr;36(4):455-70
references.pmid: 9670605
references.citation: Arch Gen Psychiatry. 2010 Oct;67(10):1002-11
references.pmid: 20921116
references.citation: Eur Arch Psychiatry Clin Neurosci. 2011 Apr;261(3):185-94
references.pmid: 21113608
references.citation: Psychiatry Clin Neurosci. 2009 Jun;63(3):266-76
references.pmid: 19566756
references.citation: Psychiatry Res. 2009 Aug 30;173(2):128-34
references.pmid: 19560907
references.citation: Psychiatry Res. 2013 Oct 30;214(1):9-15
references.pmid: 23953332
references.citation: Arch Gen Psychiatry. 2012 Nov;69(11):1169-78
references.pmid: 23117638
references.citation: PLoS One. 2014 Feb 11;9(2):e88523
references.pmid: 24523911
references.citation: Psychiatry Res. 1994 Apr;52(1):35-42
references.pmid: 8047620
references.citation: J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
references.pmid: 14399272
references.citation: Neuroimage. 2004 Mar;21(3):1155-66
references.pmid: 15006682
references.citation: Arch Gen Psychiatry. 2005 Mar;62(3):282-8
references.pmid: 15753241
references.citation: Brain Struct Funct. 2010 Jun;214(5-6):655-67
references.pmid: 20512370
references.citation: Am J Psychiatry. 2007 Oct;164(10 ):1476-88
references.pmid: 17898336