title: NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?
abstract: Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF). NADPH oxidases (Nox) are a major source of ROS in the vasculature and are key players in mediating redox signalling under physiological and pathophysiological conditions. In this review, we focus on the Nox-mediated ROS signalling pathways involved in the regulation of 'longevity genes' and recapitulate their role in age-associated vascular changes and in the development of age-related cardiovascular diseases (CVDs). This review is predicated on burgeoning knowledge that Nox-derived ROS propagate tightly regulated yet varied signalling pathways, which, at the cellular level, may lead to diminished repair, the aging process and predisposition to CVDs. In addition, we briefly describe emerging Nox therapies and their potential in improving the health of the elderly population.
authors.affiliation: Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A.
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Sahoo
authors.affiliation: Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A.
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Meijles
authors.affiliation: Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A. pagano@pitt.edu.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Pagano
mesh_terms: D000375:Aging / Q000378:metabolism*; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000201:enzymology*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D019255:NADPH Oxidases / Q000502:physiology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002317:Cardiovascular Agents; D019255:NADPH Oxidases
keywords: Aging; NADPH oxidase; aging; cardiovascular diseases; hypertension; oxidative stress; reduced nicotinamide–adenine dinucleotide phosphate (NADPH) oxidase; reduced nicotinamide–adenine dinucleotide phosphate oxidase therapeutics (Nox therapeutics); signalling pathway
references.citation: Free Radic Biol Med. 2011 Sep 15;51(6):1116-25
references.pmid: 21586323
references.citation: Lancet. 2010 Jul 24;376(9737):259-66
references.pmid: 20580423
references.citation: Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):653-61
references.pmid: 19910640
references.citation: Nature. 2002 Jan 3;415(6867):45-53
references.pmid: 11780111
references.citation: Biochim Biophys Acta. 2005 Sep 25;1752(2):186-96
references.pmid: 16140048
references.citation: J Biol Chem. 2008 Dec 12;283(50):35273-82
references.pmid: 18849343
references.citation: Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2714-21
references.pmid: 17823367
references.citation: Curr Biol. 2004 May 25;14(10):885-90
references.pmid: 15186745
references.citation: Cardiovasc Res. 1997 Jan;33(1):216-22
references.pmid: 9059547
references.citation: Genes Cells. 2013 Jan;18(1):32-41
references.pmid: 23216904
references.citation: Aging Dis. 2010 Oct 1;1(2):72-74
references.pmid: 21132086
references.citation: J Mol Cell Cardiol. 2010 Apr;48(4):765-72
references.pmid: 20079746
references.citation: Am J Physiol Heart Circ Physiol. 2001 Sep;281(3):H1422-32
references.pmid: 11514315
references.citation: Circulation. 2011 Sep 6;124(10):1107-17
references.pmid: 21844076
references.citation: Am J Hypertens. 2007 Jul;20(7):792-9
references.pmid: 17586415
references.citation: Circ Res. 2000 Aug 4;87(3):179-83
references.pmid: 10926866
references.citation: J Physiol Biochem. 2000 Mar;56(1):57-64
references.pmid: 10879682
references.citation: Cardiovasc Res. 2013 Aug 1;99(3):395-403
references.pmid: 23650288
references.citation: J Gerontol. 1956 Jul;11(3):298-300
references.pmid: 13332224
references.citation: Am J Physiol Heart Circ Physiol. 2014 Jan 15;306(2):H197-205
references.pmid: 24213612
references.citation: Antioxid Redox Signal. 2001 Aug;3(4):611-23
references.pmid: 11554448
references.citation: Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R793-802
references.pmid: 18199585
references.citation: Antioxid Redox Signal. 2014 Jun 10;20(17):2741-54
references.pmid: 24070014
references.citation: Br J Pharmacol. 2010 Oct;161(4):885-98
references.pmid: 20860666
references.citation: Planta Med. 2013 Mar;79(3-4):244-52
references.pmid: 23345167
references.citation: Biochemistry. 2014 Aug 12;53(31):5111-20
references.pmid: 25062272
references.citation: Arterioscler Thromb Vasc Biol. 2014 May;34(5):985-95
references.pmid: 24651677
references.citation: Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14483-8
references.pmid: 9405639
references.citation: Free Radic Biol Med. 2012 Feb 15;52(4):725-34
references.pmid: 22182486
references.citation: Free Radic Biol Med. 2009 Nov 1;47(9):1254-66
references.pmid: 19628034
references.citation: Aging (Albany NY). 2010 Aug;2(8):471-4
references.pmid: 20729567
references.citation: Am J Pathol. 1991 Nov;139(5):1119-29
references.pmid: 1951629
references.citation: J Am Coll Cardiol. 2008 Jan 1;51(1):68-74
references.pmid: 18174039
references.citation: Nature. 2004 May 6;429(6987):86-92
references.pmid: 15103385
references.citation: Cell Mol Life Sci. 2012 Jul;69(14):2327-43
references.pmid: 22648375
references.citation: J Am Coll Cardiol. 2007 Jul 3;50(1):1-13
references.pmid: 17601538
references.citation: Rejuvenation Res. 2007 Dec;10(4):501-12
references.pmid: 17979500
references.citation: N Engl J Med. 2002 Jun 20;346(25):1954-62
references.pmid: 12075056
references.citation: J Neuroinflammation. 2012;9:32
references.pmid: 22340895
references.citation: J Med Chem. 2010 Nov 11;53(21):7715-30
references.pmid: 20942471
references.citation: J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D42-50
references.pmid: 24355641
references.citation: Antioxid Redox Signal. 2009 Jun;11(6):1279-87
references.pmid: 19061439
references.citation: Diabetes. 2001 Jun;50(6):1414-24
references.pmid: 11375343
references.citation: Cardiovasc Ther. 2013 Jun;31(3):125-37
references.pmid: 22280098
references.citation: Aging (Albany NY). 2010 Dec;2(12):1012-6
references.pmid: 21212466
references.citation: Am J Respir Crit Care Med. 2012 Oct 15;186(8):790-6
references.pmid: 22798320
references.citation: Cardiovasc Res. 2013 Jan 1;97(1):134-42
references.pmid: 22997161
references.citation: J Clin Invest. 1997 Oct 15;100(8):1991-9
references.pmid: 9329962
references.citation: Free Radic Biol Med. 2012 Jan 1;52(1):1-6
references.pmid: 22027063
references.citation: J Biol Chem. 2014 Aug 15;289(33):22759-70
references.pmid: 24970888
references.citation: Science. 1994 Feb 25;263(5150):1128-30
references.pmid: 8108730
references.citation: Circ Res. 1991 Jun;68(6):1560-8
references.pmid: 2036710
references.citation: Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):846-51
references.pmid: 9927656
references.citation: Circulation. 2003 Oct 21;108(16):1912-6
references.pmid: 14568884
references.citation: Circ Res. 2005 Sep 30;97(7):629-36
references.pmid: 16123335
references.citation: Circulation. 2005 Oct 25;112(17):2668-76
references.pmid: 16230485
references.citation: Circ Res. 2012 Apr 27;110(9):1159-61
references.pmid: 22539753
references.citation: Circulation. 2006 Aug 29;114(9):953-60
references.pmid: 16908765
references.citation: Nature. 1997 Nov 6;390(6655):45-51
references.pmid: 9363890
references.citation: Arterioscler Thromb Vasc Biol. 1999 Sep;19(9):2119-26
references.pmid: 10479653
references.citation: Circ Res. 2006 Sep 29;99(7):675-91
references.pmid: 17008597
references.citation: Nature. 1999 May 13;399(6732):162-6
references.pmid: 10335847
references.citation: Science. 2005 Nov 18;310(5751):1193-6
references.pmid: 16293764
references.citation: Antioxid Redox Signal. 2009 Oct;11(10):2371-84
references.pmid: 19309260
references.citation: J Biol Chem. 2010 Jan 8;285(2):1153-65
references.pmid: 19892704
references.citation: Cell Mol Life Sci. 2000 May;57(5):738-46
references.pmid: 10892340
references.citation: J Biol Chem. 2014 Aug 29;289(35):24700-15
references.pmid: 25037225
references.citation: Circulation. 2001 Jul 10;104(2):174-80
references.pmid: 11447082
references.citation: J Biol Chem. 2006 Mar 17;281(11):6904-9
references.pmid: 16377630
references.citation: Lancet. 1990 Aug 4;336(8710):285-8
references.pmid: 1973979
references.citation: Oncogene. 2005 Apr 21;24(18):2929-43
references.pmid: 15735718
references.citation: Circulation. 2002 Aug 20;106(8):927-32
references.pmid: 12186795
references.citation: Mol Cell Biol. 1995 Jul;15(7):3892-903
references.pmid: 7791795
references.citation: Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18121-6
references.pmid: 20921387
references.citation: Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L566-75
references.pmid: 25063799
references.citation: Physiol Rev. 2007 Jan;87(1):245-313
references.pmid: 17237347
references.citation: Trends Biochem Sci. 2002 Jul;27(7):339-44
references.pmid: 12114022
references.citation: Cardiovasc Res. 2011 Jul 1;91(1):62-70
references.pmid: 21289011
references.citation: JAMA. 2012 Nov 7;308(17):1751-60
references.pmid: 23117775
references.citation: Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1838-44
references.pmid: 12426213
references.citation: Am Heart J. 2008 Jun;155(6):1006-12
references.pmid: 18513511
references.citation: Cell Cycle. 2012 Dec 15;11(24):4589-96
references.pmid: 23187810
references.citation: J Biol Chem. 2010 Aug 20;285(34):26545-57
references.pmid: 20558727
references.citation: Hypertension. 2009 Oct;54(4):810-7
references.pmid: 19635988
references.citation: Apoptosis. 2007 Sep;12(9):1733-42
references.pmid: 17505786
references.citation: J Biol Chem. 2000 May 12;275(19):14624-31
references.pmid: 10799549
references.citation: Physiol Rev. 1993 Apr;73(2):413-67
references.pmid: 8475195
references.citation: J Am Coll Cardiol. 2010 Feb 2;55(5):469-80
references.pmid: 20117462
references.citation: Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2166-77
references.pmid: 22427511
references.citation: J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1212-20
references.pmid: 19776219
references.citation: Cell. 2005 Jul 29;122(2):221-33
references.pmid: 16051147
references.citation: Drug Discov Today. 2014 Oct;19(10):1530-46
references.pmid: 24786464
references.citation: Science. 1996 May 17;272(5264):1010-3
references.pmid: 8638122
references.citation: Circ Res. 2000 Mar 17;86(5):494-501
references.pmid: 10720409
references.citation: Lancet. 2009 Feb 28;373(9665):739-45
references.pmid: 19249635
references.citation: Free Radic Biol Med. 2007 Sep 15;43(6):976-86
references.pmid: 17697942
references.citation: Br J Pharmacol. 2014 Jan;171(2):523-35
references.pmid: 24372553
references.citation: Circ Res. 2000 May 12;86(9):E85-90
references.pmid: 10807876
references.citation: Circ Res. 2002 Jun 14;90(11):1205-13
references.pmid: 12065324
references.citation: J Pathol. 2009 Sep;219(1):3-15
references.pmid: 19562738
references.citation: J Hypertens. 2014 Jun;32(6):1293-9
references.pmid: 24686009
references.citation: Chem Biol. 2012 Jun 22;19(6):752-63
references.pmid: 22726689
references.citation: Circulation. 2005 Aug 30;112(9):1266-73
references.pmid: 16129811
references.citation: Circulation. 2001 Nov 27;104(22):2638-40
references.pmid: 11723010
references.citation: Nature. 2007 Jul 19;448(7151):375-9
references.pmid: 17637672
references.citation: Antioxid Redox Signal. 2008 Oct;10(10):1687-98
references.pmid: 18593227
references.citation: Hypertension. 1997 Aug;30(2 Pt 1):252-8
references.pmid: 9260989
references.citation: Genes Dev. 2004 Feb 1;18(3):306-19
references.pmid: 14871929
references.citation: Circulation. 2013 May 7;127(18):1888-902
references.pmid: 23564668
references.citation: Cardiovasc Res. 2012 Apr 1;94(1):20-9
references.pmid: 22287576
references.citation: Eur J Cardiovasc Prev Rehabil. 2008 Dec;15(6):735-41
references.pmid: 19020458
references.citation: Science. 1995 Oct 13;270(5234):296-9
references.pmid: 7569979
references.citation: Circulation. 2013 Jan 1;127(1):e6-e245
references.pmid: 23239837
references.citation: Free Radic Biol Med. 2011 Oct 1;51(7):1271-88
references.pmid: 21722728
references.citation: Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10469-74
references.pmid: 11517304
references.citation: Trends Endocrinol Metab. 2014 Sep;25(9):452-63
references.pmid: 25066192
references.citation: Circ Res. 2007 Aug 3;101(3):258-67
references.pmid: 17585072
references.citation: Biol Chem. 2008 Mar;389(3):233-41
references.pmid: 18177265
references.citation: Nat Rev Cancer. 2002 Aug;2(8):594-604
references.pmid: 12154352
references.citation: Circulation. 2013 Apr 23;127(16):1664-76
references.pmid: 23513067
references.citation: J Neurosci. 2013 Oct 9;33(41):16346-59
references.pmid: 24107965
references.citation: Biochem Biophys Res Commun. 1998 Jul 20;248(2):324-9
references.pmid: 9675134
references.citation: Int J Hypertens. 2013;2013:842827
references.pmid: 23606947
references.citation: Cell Metab. 2013 Sep 3;18(3):416-30
references.pmid: 24011076
references.citation: Circulation. 2005 Oct 25;112(17):2677-85
references.pmid: 16246966
references.citation: Cell. 2013 Jun 6;153(6):1194-217
references.pmid: 23746838
references.citation: Am J Hum Genet. 2003 May;72(5):1154-61
references.pmid: 12669274
references.citation: Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H24-32
references.pmid: 19837950
references.citation: ACS Chem Biol. 2010 Oct 15;5(10):981-93
references.pmid: 20715845
references.citation: Circ Res. 2005 Mar 4;96(4):412-8
references.pmid: 15677572
references.citation: Biochem Biophys Res Commun. 2000 Sep 24;276(2):767-72
references.pmid: 11027545
references.citation: Curr Biol. 2007 Oct 9;17(19):1646-56
references.pmid: 17900900
references.citation: J Am Coll Cardiol. 1998 Jul;32(1):197-204
references.pmid: 9669270
references.citation: Biochim Biophys Acta. 2004 Jun 28;1657(1):1-22
references.pmid: 15238208
references.citation: Circ Res. 2000 Nov 10;87(10):840-4
references.pmid: 11073878
references.citation: Circulation. 2014 Oct 21;130(17):1452-65
references.pmid: 25156994
references.citation: J Mol Med (Berl). 2012 Dec;90(12):1391-406
references.pmid: 23090009
references.citation: Oncogene. 2005 Jan 13;24(3):367-80
references.pmid: 15531919
references.citation: Nature. 1997 May 15;387(6630):296-9
references.pmid: 9153395
references.citation: Bioorg Med Chem. 2011 Dec 1;19(23):6989-99
references.pmid: 22041175
references.citation: J Mol Cell Cardiol. 2013 Sep;62:72-9
references.pmid: 23643589
references.citation: IUBMB Life. 2005 Apr-May;57(4-5):277-81
references.pmid: 16036611
references.citation: Circulation. 1997 Feb 4;95(3):557-9
references.pmid: 9024136
references.citation: Rejuvenation Res. 2008 Aug;11(4):725-33
references.pmid: 18729805
references.citation: J Biol Chem. 2008 Dec 5;283(49):34283-93
references.pmid: 18838380
references.citation: Circulation. 2010 May 25;121(20):2200-10
references.pmid: 20458013
references.citation: Cardiovasc Pathol. 2011 Mar-Apr;20(2):99-106
references.pmid: 20080418
references.citation: Circ Res. 2009 Jul 31;105(3):249-59
references.pmid: 19574552
references.citation: Am J Respir Cell Mol Biol. 2012 Nov;47(5):718-26
references.pmid: 22904198
references.citation: J Biol Chem. 2004 Jun 11;279(24):25689-95
references.pmid: 15078873
references.citation: Oncogene. 2003 Dec 8;22(56):9030-40
references.pmid: 14663481
references.citation: Hypertension. 2010 Jan;55(1):116-23
references.pmid: 19917877
references.citation: Hypertension. 2007 Jul;50(1):219-27
references.pmid: 17452499
references.citation: Aging Cell. 2009 Feb;8(1):73-5
references.pmid: 19077044
references.citation: Biochem J. 2007 Oct 1;407(1):79-87
references.pmid: 17600529
references.citation: IUBMB Life. 2007 Apr-May;59(4-5):249-54
references.pmid: 17505961
references.citation: Nat Commun. 2010;1:3
references.pmid: 20975665
references.citation: Aging Cell. 2009 Aug;8(4):460-72
references.pmid: 19489743
references.citation: Free Radic Biol Med. 2008 Feb 1;44(3):235-46
references.pmid: 18021748
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2001 Oct;25(7):1341-57
references.pmid: 11513350
references.citation: Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H1882-94
references.pmid: 18757483
references.citation: Nat Rev Mol Cell Biol. 2014 Jul;15(7):482-96
references.pmid: 24954210
references.citation: Nature. 2003 Jul 17;424(6946):277-83
references.pmid: 12845331
references.citation: Circulation. 2012 May 8;125(18):2243-55
references.pmid: 22492635
references.citation: Am J Respir Cell Mol Biol. 2009 May;40(5):601-9
references.pmid: 18952568
references.citation: Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L2-10
references.pmid: 16085672
references.citation: Science. 2007 Feb 2;315(5812):659-63
references.pmid: 17272725
references.citation: Cell. 2003 Mar 21;112(6):779-91
references.pmid: 12654245
references.citation: Br J Pharmacol. 2005 Sep;146(1):109-17
references.pmid: 15980872
references.citation: Trends Pharmacol Sci. 2003 Sep;24(9):471-8
references.pmid: 12967772
references.citation: Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E89-98
references.pmid: 23236145
references.citation: Hypertension. 2004 Sep;44(3):248-52
references.pmid: 15262903
references.citation: Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):304-12
references.pmid: 24334871
references.citation: Am J Physiol Heart Circ Physiol. 2000 Nov;279(5):H2234-40
references.pmid: 11045958
references.citation: J Gerontol A Biol Sci Med Sci. 2012 Apr;67(4):313-29
references.pmid: 22021391
references.citation: J Biol Chem. 2001 Sep 28;276(39):36194-9
references.pmid: 11447225
references.citation: Biochem Biophys Res Commun. 2002 Apr 26;293(1):332-7
references.pmid: 12054604
references.citation: Nature. 2000 Nov 23;408(6811):492-5
references.pmid: 11100733
references.citation: Free Radic Biol Med. 2000 May 15;28(10):1456-62
references.pmid: 10927169
references.citation: Atherosclerosis. 2012 Jul;223(1):122-9
references.pmid: 22658259
references.citation: FEBS Lett. 2003 Sep 11;551(1-3):58-62
references.pmid: 12965205
references.citation: Circulation. 1999 Oct 5;100(14):1494-8
references.pmid: 10510050
references.citation: J Am Soc Nephrol. 2011 Jan;22(1):124-36
references.pmid: 21115613
references.citation: Neuroscience. 2013 Mar 1;232:1-12
references.pmid: 23246618
references.citation: J Clin Invest. 1996 Apr 15;97(8):1916-23
references.pmid: 8621776
references.citation: Cell. 1993 Oct 8;75(1):59-72
references.pmid: 8402901
references.citation: Protein Cell. 2011 Jun;2(6):456-62
references.pmid: 21748595
references.citation: Mol Cell Biol. 2003 Feb;23(3):916-22
references.pmid: 12529397
references.citation: J Am Coll Cardiol. 2007 Jul 24;50(4):359-67
references.pmid: 17659204
references.citation: Heart Fail Rev. 2002 Jan;7(1):29-49
references.pmid: 11790921
references.citation: J Biol Chem. 2007 Jan 19;282(3):1797-804
references.pmid: 17098746
references.citation: N Engl J Med. 1999 Jan 14;340(2):115-26
references.pmid: 9887164
references.citation: Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1704-15
references.pmid: 24947524
references.citation: Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):776-82
references.pmid: 12637340
references.citation: Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S127-36
references.pmid: 20590828
references.citation: Science. 2002 Mar 29;295(5564):2450-2
references.pmid: 11884717
references.citation: J Biol Chem. 2001 Dec 21;276(51):48332-6
references.pmid: 11602589
references.citation: Medchemcomm. 2013 Jul;4(7):1085-1092
references.pmid: 24466406
references.citation: Cell Death Differ. 2010 Jan;17(1):86-92
references.pmid: 19543236
references.citation: Stroke. 1991 Aug;22(8):983-8
references.pmid: 1866765
references.citation: Semin Cancer Biol. 2009 Feb;19(1):32-41
references.pmid: 19101635
references.citation: Science. 2000 Sep 22;289(5487):2126-8
references.pmid: 11000115
references.citation: Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1398-403
references.pmid: 17085535
references.citation: Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2112-6
references.pmid: 12571362
references.citation: Genetics. 1995 Mar;139(3):1247-59
references.pmid: 7768437
references.citation: Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2684-90
references.pmid: 17916769
references.citation: J Clin Invest. 2005 Mar;115(3):500-8
references.pmid: 15765131
references.citation: Nature. 1993 Dec 2;366(6454):461-4
references.pmid: 8247153
references.citation: Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1614-20
references.pmid: 15256399
references.citation: Small GTPases. 2014;5:e27952
references.pmid: 24598074
references.citation: Clin Chem. 2007 Sep;53(9):1652-7
references.pmid: 17599958
references.citation: Nat Rev Immunol. 2004 Mar;4(3):181-9
references.pmid: 15039755
references.citation: Nature. 2014 May 22;509(7501):439-46
references.pmid: 24848057
references.citation: Hypertension. 2011 Feb;57(2):245-54
references.pmid: 21173344
references.citation: Am J Clin Nutr. 2012 May;95(5):1079-88
references.pmid: 22492364
references.citation: J Biol Chem. 2000 Nov 17;275(46):35778-85
references.pmid: 10958792
references.citation: Oncogene. 2008 Nov 27;27(56):7094-105
references.pmid: 18762812
references.citation: Biochim Biophys Acta. 2009 Oct;1790(10):1049-58
references.pmid: 19230844
references.citation: Nat Genet. 1995 Dec;11(4):376-81
references.pmid: 7493016
references.citation: Hypertension. 2008 Jul;52(1):143-9
references.pmid: 18474828
references.citation: J Biol Chem. 2005 Nov 11;280(45):38029-34
references.pmid: 16186101
references.citation: Nucleic Acids Res. 2002 Jun 1;30(11):2340-8
references.pmid: 12034820
references.citation: J Am Coll Cardiol. 2008 Nov 25;52(22):1803-9
references.pmid: 19022160
references.citation: Nat Rev Cancer. 2004 Oct;4(10):793-805
references.pmid: 15510160
references.citation: Front Physiol. 2012 Jun 05;3:140
references.pmid: 22679437
references.citation: Curr Opin Cell Biol. 2003 Apr;15(2):247-54
references.pmid: 12648682
references.citation: Proc Natl Acad Sci U S A. 2010 May 25;107(21):9660-4
references.pmid: 20457898
references.citation: Circulation. 2011 Mar 1;123(8):933-44
references.pmid: 21262990
references.citation: Circ Res. 2010 Apr 30;106(8):1363-73
references.pmid: 20339118
references.citation: Am J Physiol Cell Physiol. 2008 Jan;294(1):C145-52
references.pmid: 18032526
references.citation: Circulation. 1997 Nov 18;96(10):3264-5
references.pmid: 9396412
references.citation: FEBS Lett. 2011 Sep 16;585(18):2803-9
references.pmid: 21624367
references.citation: FEBS Lett. 2006 Oct 16;580(24):5753-8
references.pmid: 17014852
references.citation: Science. 2003 May 16;300(5622):1142-5
references.pmid: 12750521
references.citation: Circ Res. 2001 Aug 31;89(5):408-14
references.pmid: 11532901
references.citation: Redox Biol. 2014;2:642-50
references.pmid: 24936437
references.citation: Circulation. 2009 May 12;119(18):2516-25
references.pmid: 19433768
references.citation: Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15998-6003
references.pmid: 15520384
references.citation: Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11848-52
references.pmid: 8876226
references.citation: Science. 1996 Jul 5;273(5271):80
references.pmid: 8658201
references.citation: Cardiovasc Res. 2002 Apr;54(1):25-35
references.pmid: 12062358
references.citation: Circulation. 2002 Mar 26;105(12):1429-35
references.pmid: 11914250
references.citation: Cardiovasc Res. 2007 Sep 1;75(4):679-89
references.pmid: 17689510
references.citation: J Biol Chem. 2013 Dec 20;288(51):36437-50
references.pmid: 24187133
references.citation: Hypertension. 2000 May;35(5):1055-61
references.pmid: 10818064
references.citation: Oncogene. 2002 May 30;21(24):3872-8
references.pmid: 12032825
references.citation: Mol Biol Cell. 2013 Sep;24(17):2739-52
references.pmid: 23825024
references.citation: Free Radic Biol Med. 2004 Jan 1;36(1):53-64
references.pmid: 14732290
references.citation: Circulation. 1997 Jul 1;96(1):308-15
references.pmid: 9236450
references.citation: J Clin Invest. 2001 Nov;108(10):1513-22
references.pmid: 11714743
references.citation: Science. 2005 Sep 16;309(5742):1829-33
references.pmid: 16123266
references.citation: Nat Rev Drug Discov. 2011 Jun;10(6):453-71
references.pmid: 21629295
references.citation: J Biol Chem. 2001 May 25;276(21):18399-406
references.pmid: 11279008
references.citation: Diabetes. 2010 Jan;59(1):135-42
references.pmid: 19833883
references.citation: Cell. 2008 Mar 21;132(6):1025-38
references.pmid: 18358814
references.citation: J Cell Mol Med. 2012 Jan;16(1):83-95
references.pmid: 21418519
references.citation: J Am Coll Cardiol. 2008 Feb 26;51(8):802-9
references.pmid: 18294563
references.citation: Int J Cardiol. 2013 Sep 30;168(2):871-80
references.pmid: 23164592
references.citation: Circ Res. 2012 May 11;110(10):1364-90
references.pmid: 22581922
references.citation: Ann Thorac Surg. 2004 Apr;77(4):1288-92
references.pmid: 15063253
references.citation: Antioxid Redox Signal. 2015 Aug 10;23(5):406-27
references.pmid: 24383718
references.citation: Aging Cell. 2012 Jun;11(3):410-7
references.pmid: 22260450
references.citation: Nat Cell Biol. 2010 Jul;12(7):676-85
references.pmid: 20526329
references.citation: Int J Cardiol. 2007 Feb 7;115(2):135-43
references.pmid: 16764958
references.citation: Cell. 1992 Jul 10;70(1):93-104
references.pmid: 1623525
references.citation: Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):435-44
references.pmid: 14604834
references.citation: Atherosclerosis. 2011 Jun;216(2):321-6
references.pmid: 21411092
references.citation: Nature. 1999 Nov 18;402(6759):309-13
references.pmid: 10580504
references.citation: Chest. 2011 Jan;139(1):128-37
references.pmid: 20558556
references.citation: Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3438-42
references.pmid: 18316725
references.citation: Cardiovasc Res. 2006 Jul 15;71(2):331-41
references.pmid: 16545786