title: Skeletal Muscle Loading Changes its Regenerative Capacity.
abstract: Whenever skeletal muscle insults occur, both by functional impositions or other injury forms, skeletal muscle repair (SMR) follows. The SMR succeeds when proper skeletal muscle regeneration and limited fibrosis ensue. Muscle fiber replenishment by fibrosis negatively affects the tissue quality and functionality and, furthermore, represents the worst post-injury phenotypic adaptation. Acute muscle injury treatment commonly follows the RICE method-rest, ice, compression, and elevation. This immediate immobilization seems to be beneficial to preserving the tissue structure and avoiding further destruction; however, if these interventions are delayed, the risk of muscle atrophy and its deleterious-related effects increase, with resultant impaired SMR. Moreover, a growing body of evidence shows positive skeletal muscle loading (SML) effects during SMR since it seems to effectively increase satellite cells (SCs) in their activation, proliferation, self-renewal, and differentiation capacities. Additionally, recent data show that SML may also influence the functions of other participants in SMR, compelling SMR to achieve less fibrotic accretion and accelerated muscle mass recovery. Moreover, given the SML effects on SCs, it is plausible to consider that these can increase the myofibers' basal myogenic potential. Thus, it seems relevant to scrutinize the possible acute and chronic SML therapeutic and prophylactic effects regarding the SMR process.
authors.affiliation: Centro de Investigação em Atividade Física e Saúde, Faculdade de Desporto da Universidade do Porto (CIAFEL-FADEUP), Rua Dr. Plácido Costa 91, 4200-450, Porto, Portugal. edsilvateixeira@hotmail.com.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Teixeira
authors.affiliation: Centro de Investigação em Atividade Física e Saúde, Faculdade de Desporto da Universidade do Porto (CIAFEL-FADEUP), Rua Dr. Plácido Costa 91, 4200-450, Porto, Portugal.
authors.forename: José Alberto
authors.initials: JA
authors.lastname: Duarte
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D005355:Fibrosis / Q000517:prevention & control; D006801:Humans; D018482:Muscle, Skeletal / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D009133:Muscular Atrophy / Q000517:prevention & control; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology; D016474:Weight-Bearing
references.citation: Science. 2005 Nov 18;310(5751):1139-43
references.pmid: 16293750
references.citation: Cell Stem Cell. 2008 Jan 10;2(1):22-31
references.pmid: 18371418
references.citation: Age (Dordr). 2014 Apr;36(2):545-7
references.pmid: 24122288
references.citation: J Gerontol A Biol Sci Med Sci. 2013 Jul;68(7):769-79
references.pmid: 23223011
references.citation: J Musculoskelet Neuronal Interact. 2011 Dec;11(4):286-97
references.pmid: 22130137
references.citation: Br J Sports Med. 2013 Oct;47(15):953-9
references.pmid: 23536466
references.citation: EMBO Mol Med. 2009 Nov;1(8-9):381-91
references.pmid: 20049743
references.citation: J Biomech. 2010 Jan 5;43(1):55-62
references.pmid: 19800626
references.citation: Trends Pharmacol Sci. 2007 Apr;28(4):152-6
references.pmid: 17331593
references.citation: Best Pract Res Clin Rheumatol. 2007 Apr;21(2):317-31
references.pmid: 17512485
references.citation: Nat Rev Mol Cell Biol. 2011 Dec 21;13(2):127-33
references.pmid: 22186952
references.citation: Acta Physiol (Oxf). 2014 Mar;210(3):460-1
references.pmid: 24393289
references.citation: J Physiol. 2011 Nov 15;589(Pt 22):5503-15
references.pmid: 21946848
references.citation: J Appl Physiol (1985). 2009 Mar;106(3):804-12
references.pmid: 19131480
references.citation: Front Physiol. 2014 Mar 17;5:99
references.pmid: 24672488
references.citation: Nat Commun. 2013;4:1964
references.pmid: 23743995
references.citation: J Appl Physiol (1985). 2002 Nov;93(5):1691-7
references.pmid: 12381755
references.citation: Cochrane Database Syst Rev. 2012 Dec 12;12:CD004575
references.pmid: 23235611
references.citation: J Musculoskelet Neuronal Interact. 2014 Sep;14(3):325-33
references.pmid: 25198228
references.citation: Mol Biol Cell. 2007 Apr;18(4):1397-409
references.pmid: 17287398
references.citation: Scand J Med Sci Sports. 2007 Feb;17(1):34-42
references.pmid: 17305939
references.citation: Physiol Rev. 2013 Jan;93(1):23-67
references.pmid: 23303905
references.citation: Cell Mol Life Sci. 2013 Nov;70(21):4117-30
references.pmid: 23552962
references.citation: Acta Physiol (Oxf). 2015 Mar;213(3):537-8
references.pmid: 25565243
references.citation: Cold Spring Harb Symp Quant Biol. 2008;73:323-31
references.pmid: 19329572
references.citation: Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C854-61
references.pmid: 22895262
references.citation: Am J Phys Med Rehabil. 2013 Nov;92(11):1020-30
references.pmid: 23811616
references.citation: Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E151-7
references.pmid: 16926381
references.citation: EMBO Rep. 2013 Dec;14(12):1062-72
references.pmid: 24232182
references.citation: Br J Sports Med. 2014 Apr;48(7):532-9
references.pmid: 24620041
references.citation: Muscle Nerve. 2006 Feb;33(2):242-53
references.pmid: 16315322
references.citation: Acta Physiol (Oxf). 2014 Mar;210(3):462-4
references.pmid: 24373175
references.citation: Muscle Nerve. 2008 Sep;38(3):1147-54
references.pmid: 18671293
references.citation: Int J Biochem Cell Biol. 2014 Nov;56:56-65
references.pmid: 25242742
references.citation: Cell Mol Life Sci. 2015 Jun;72(11):2135-56
references.pmid: 25854633
references.citation: Cell Biochem Funct. 2007 Jan-Feb;25(1):63-73
references.pmid: 16906627
references.citation: Science. 2006 Mar 31;311(5769):1880-5
references.pmid: 16574858
references.citation: J Appl Physiol (1985). 2009 Oct;107(4):1006-14
references.pmid: 19696361
references.citation: Am J Physiol Cell Physiol. 2008 Feb;294(2):C467-76
references.pmid: 18077604
references.citation: Semin Cell Dev Biol. 2010 Oct;21(8):845-54
references.pmid: 20849971
references.citation: PLoS One. 2012;7(1):e30348
references.pmid: 22253929
references.citation: Am J Physiol Regul Integr Comp Physiol. 2010 May;298(5):R1173-87
references.pmid: 20219869
references.citation: Nature. 2013 May 9;497(7448):196-7
references.pmid: 23615614
references.citation: Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R337-44
references.pmid: 15637170
references.citation: Sports Health. 2014 Jul;6(4):348-55
references.pmid: 24982709
references.citation: Acta Physiol (Oxf). 2014 Mar;210(3):612-27
references.pmid: 24219628
references.citation: Exp Physiol. 2014 Nov;99(11):1449-50
references.pmid: 25362647
references.citation: J Appl Physiol (1985). 2008 Jun;104(6):1736-42
references.pmid: 18436694
references.citation: Eur J Appl Physiol. 2006 Jun;97(3):340-6
references.pmid: 16770471
references.citation: Clin Sci (Lond). 2014 Apr;126(8):557-66
references.pmid: 24215591
references.citation: Physiol Rev. 2004 Jan;84(1):209-38
references.pmid: 14715915
references.citation: Dev Biol. 2005 Mar 15;279(2):336-44
references.pmid: 15733662
references.citation: Am J Physiol Endocrinol Metab. 2013 Mar 1;304(5):E453-65
references.pmid: 23277185
references.citation: Arch Phys Med Rehabil. 2006 Jan;87(1):20-6
references.pmid: 16401433
references.citation: J Cell Biochem. 2008 Oct 15;105(3):663-9
references.pmid: 18759329
references.citation: FASEB J. 2012 Jun;26(6):2509-21
references.pmid: 22403007
references.citation: Front Physiol. 2014 Dec 11;5:485
references.pmid: 25566087
references.citation: J Appl Physiol (1985). 2011 Jan;110(1):264-74
references.pmid: 21030673
references.citation: Compr Physiol. 2013 Jul;3(3):1337-62
references.pmid: 23897689
references.citation: FASEB J. 2013 Nov;27(11):4596-605
references.pmid: 23928822
references.citation: Age (Dordr). 2014;36(4):9699
references.pmid: 25108351
references.citation: Exp Physiol. 2012 Jun;97(6):762-73
references.pmid: 22327327
references.citation: Scand J Med Sci Sports. 2011 Dec;21(6):773-82
references.pmid: 21143306
references.citation: Tissue Eng Part A. 2010 Mar;16(3):839-49
references.pmid: 19788347
references.citation: Muscle Nerve. 2011 Mar;43(3):393-401
references.pmid: 21321955
references.citation: J Physiol. 2013 Aug 1;591(15):3789-804
references.pmid: 23732643
references.citation: Development. 2011 Sep;138(17):3657-66
references.pmid: 21828094
references.citation: Sci Transl Med. 2014 Apr 30;6(234):234ra58
references.pmid: 24786326
references.citation: J Anat. 2006 Apr;208(4):445-50
references.pmid: 16637870
references.citation: J Physiol. 2004 Aug 1;558(Pt 3):1005-12
references.pmid: 15218062
references.citation: Physiol Rev. 2008 Oct;88(4):1379-406
references.pmid: 18923185
references.citation: J Cell Biochem. 2011 Jan;112(1):1-9
references.pmid: 20626029
references.citation: Muscle Nerve. 2003 Jul;28(1):87-92
references.pmid: 12811778
references.citation: Med Sci Sports Exerc. 2013 Feb;45(2):230-7
references.pmid: 22968308
references.citation: J Physiol. 2014 Jun 15;592(12):2625-35
references.pmid: 24687582
references.citation: J Physiol. 2004 Jul 1;558(Pt 1):333-40
references.pmid: 15121802
references.citation: J Gerontol A Biol Sci Med Sci. 2009 Mar;64(3):332-9
references.pmid: 19196907
references.citation: J Appl Physiol (1985). 2005 Dec;99(6):2406-15
references.pmid: 16081620
references.citation: Science. 2000 Feb 25;287(5457):1427-30
references.pmid: 10688781
references.citation: Curr Opin Rheumatol. 2011 Nov;23(6):568-73
references.pmid: 21934499
references.citation: PLoS One. 2014 Oct 14;9(10):e109739
references.pmid: 25313863
references.citation: Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1206-10
references.pmid: 14745025
references.citation: J Anat. 2009 Nov;215(5):477-97
references.pmid: 19702867
references.citation: Acta Physiol (Oxf). 2012 Mar;204(3):393-402
references.pmid: 21854550
references.citation: Development. 2012 Aug;139(16):2845-56
references.pmid: 22833472
references.citation: Cell. 2006 Aug 25;126(4):677-89
references.pmid: 16923388
references.citation: Trends Mol Med. 2012 Oct;18(10):599-606
references.pmid: 22877884
references.citation: Acta Physiol (Oxf). 2014 Mar;210(3):628-41
references.pmid: 24251881
references.citation: J Biophys Biochem Cytol. 1961 Feb;9:493-5
references.pmid: 13768451
references.citation: Immunol Cell Biol. 2000 Oct;78(5):545-53
references.pmid: 11050538
references.citation: Mol Ther. 2004 Nov;10(5):844-54
references.pmid: 15509502
references.citation: Histochem Cell Biol. 2000 Feb;113(2):99-103
references.pmid: 10766262
references.citation: J Appl Physiol (1985). 2007 Sep;103(3):1099-100
references.pmid: 17289912
references.citation: Nature. 2013 May 9;497(7448):263-7
references.pmid: 23615608
references.citation: BMC Cell Biol. 2010 Nov 18;11:87
references.pmid: 21087483
references.citation: Exerc Immunol Rev. 2011;17:6-63
references.pmid: 21446352