title: Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer.
abstract: Colorectal cancer (CRC) is the second most common cause of cancer-related death in western countries. Approximately one-quarter of newly diagnosed patients for CRC have metastases, and a further 40%-50% experience disease recurrence or develop metastases after all standard therapies. Therefore, understanding the molecular mechanisms involved in the progression of CRC and subsequently developing novel therapeutic targets is crucial to improve management of CRC and patients' long-term survival. Several tyrosine kinase receptors have been implicated in CRC development, progression and metastasis, including epidermal growth factor receptor (EGFR) and vascular EGFR. Recently, tropomyosin-related kinase B (TrkB), a tyrosine kinase receptor, has been reported in CRC and found to clearly exert several biological and clinical features, such as tumor cell growth and survival in vitro and in vivo, metastasis formation and poor prognosis. Here we review the significance of TrkB and its ligand brain derived-neurotrophic factor in CRC. We focus on their expression in CRC tumor samples, and their functional roles in CRC cell lines and in in vivo models. Finally we discuss therapeutic approaches that can lead to the development of novel therapeutic agents for treating TrkB-expressing CRC tumors.
authors.affiliation: Hussein Akil, Aurélie Perraud, Marie-Odile Jauberteau, Muriel Mathonnet, Laboratoire Homéostasie Cellulaire et Pathologies (LHCP-EA3842), Faculté de Médecine et de Pharmacie, Fédération de Recherche GEIST, 87025 Limoges, France.
authors.forename: Hussein
authors.initials: H
authors.lastname: Akil
authors.affiliation: Hussein Akil, Aurélie Perraud, Marie-Odile Jauberteau, Muriel Mathonnet, Laboratoire Homéostasie Cellulaire et Pathologies (LHCP-EA3842), Faculté de Médecine et de Pharmacie, Fédération de Recherche GEIST, 87025 Limoges, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Perraud
authors.affiliation: Hussein Akil, Aurélie Perraud, Marie-Odile Jauberteau, Muriel Mathonnet, Laboratoire Homéostasie Cellulaire et Pathologies (LHCP-EA3842), Faculté de Médecine et de Pharmacie, Fédération de Recherche GEIST, 87025 Limoges, France.
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Jauberteau
authors.affiliation: Hussein Akil, Aurélie Perraud, Marie-Odile Jauberteau, Muriel Mathonnet, Laboratoire Homéostasie Cellulaire et Pathologies (LHCP-EA3842), Faculté de Médecine et de Pharmacie, Fédération de Recherche GEIST, 87025 Limoges, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: Mathonnet
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D055808:Drug Discovery; D006801:Humans; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020813:Receptor, trkB; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D019208:Brain-Derived Neurotrophic Factor; D008562:Membrane Glycoproteins; D047428:Protein Kinase Inhibitors; C579455:BDNF protein, human; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; C000591259:tropomyosin-related kinase-B, human
keywords: Brain-derived neurotrophic factor; Cell survival; Colorectal cancer; Therapeutic targets; Tyrosine kinase receptor B
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