title: Peculiar liquid-feeding and pathogen transmission behavior of Aedes togoi and comparison with Anopheles sinensis.
abstract: Female mosquitoes transmit various diseases as vectors during liquid-feeding. Identifying the determinants of vector efficiency is a major scientific challenge in establishing strategies against these diseases. Infection rate and transmission efficiency are interconnected with the mosquito-induced liquid-feeding flow as main indexes of vector efficiency. However, the relationship between liquid-feeding characteristics and pathogen remains poorly understood. The liquid-feeding behavior of Aedes togoi and Anopheles sinensis was comparatively investigated in conjunction with vector efficiency via micro-particle image velocimetry. The flow rates and ratio of the ejection volume of Aedes togoi were markedly higher than those of Anophels sinensis. These differences would influence pathogen re-ingestion. Wall shear stresses of these mosquito species were also clearly discriminatory affecting the infective rates of vector-borne diseases. The variations in volume of two pump chambers and diameter of proboscis of these mosquito species were compared to determine the differences in the liquid-feeding process. Liquid-feeding characteristics influence vector efficiency; hence, this study can elucidate the vector efficiency of mosquitoes and the vector-pathogen interactions and contribute to the development of strategies against vector-borne diseases.
authors.affiliation: School of Interdisciplinary Biosciences and Bioengineering, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.|Center for Biofluid and Biomimic Research, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.|Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.
authors.forename: Sang Joon
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: School of Interdisciplinary Biosciences and Bioengineering, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.|Center for Biofluid and Biomimic Research, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.
authors.forename: Dooho
authors.initials: D
authors.lastname: Kang
authors.affiliation: Center for Biofluid and Biomimic Research, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.|Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.
authors.forename: Seung Chul
authors.initials: SC
authors.lastname: Lee
authors.affiliation: Center for Biofluid and Biomimic Research, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.|Division of Integrative Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.
authors.forename: Young-Ran
authors.initials: YR
authors.lastname: Ha
mesh_terms: D000330:Aedes / Q000469:parasitology / Q000502:physiology*; D000821:Animal Feed; D000818:Animals; D000852:Anopheles / Q000469:parasitology / Q000502:physiology*; D005247:Feeding Behavior; D005260:Female; D007303:Insect Vectors / Q000502:physiology; D033081:Shear Strength
references.citation: Nature. 1996 Jan 18;379(6562):266-9
references.pmid: 8538793
references.citation: Proc Biol Sci. 2013 Jul 22;280(1763):20130711
references.pmid: 23698008
references.citation: PLoS Negl Trop Dis. 2015 Feb;9(2):e0003462
references.pmid: 25658951
references.citation: Science. 1978 Feb 24;199(4331):909-11
references.pmid: 203035
references.citation: Mem Inst Oswaldo Cruz. 2003 Jun;98(4):481-5
references.pmid: 12937758
references.citation: Lab Chip. 2009 May 7;9(9):1193-9
references.pmid: 19370236
references.citation: J Exp Biol. 2009 May;212(Pt 10):1436-41
references.pmid: 19411536
references.citation: Trends Parasitol. 2012 Nov;28(11):466-70
references.pmid: 23044288
references.citation: PLoS One. 2013;8(5):e64763
references.pmid: 23724092
references.citation: J Theor Biol. 2014 May 7;348:113-21
references.pmid: 24512912
references.citation: J Biomech. 2009 May 11;42(7):857-64
references.pmid: 19272604
references.citation: Blood. 1996 Nov 15;88(10):4040-4
references.pmid: 8916971
references.citation: Southeast Asian J Trop Med Public Health. 2014 May;45(3):588-97
references.pmid: 24974643
references.citation: Infect Immun. 2007 Nov;75(11):5532-9
references.pmid: 17785479
references.citation: Am J Trop Med Hyg. 1992 Oct;47(4):484-8
references.pmid: 1443347
references.citation: Proc Biol Sci. 1999 Sep 7;266(1430):1729-33
references.pmid: 10518321
references.citation: Emerg Infect Dis. 1998 Jul-Sep;4(3):442-50
references.pmid: 9716967
references.citation: Am J Trop Med Hyg. 2006 Dec;75(6):1200-4
references.pmid: 17172393
references.citation: Sci Rep. 2015;5:15148
references.pmid: 26464043
references.citation: PLoS One. 2015;10(6):e0131230
references.pmid: 26107619
references.citation: PLoS Pathog. 2013;9(6):e1003365
references.pmid: 23818841
references.citation: J Med Entomol. 2012 Jan;49(1):132-42
references.pmid: 22308781
references.citation: Bull World Health Organ. 1962;27:585-94
references.pmid: 13940117
references.citation: PLoS One. 2011;6(3):e17690
references.pmid: 21408119
references.citation: Prog Cardiovasc Dis. 2007 Mar-Apr;49(5):307-29
references.pmid: 17329179
references.citation: Nat Rev Immunol. 2009 May;9(5):364-75
references.pmid: 19390567
references.citation: FASEB J. 2010 Jul;24(7):2222-34
references.pmid: 20159960
references.citation: Microsc Res Tech. 2012 Aug;75(8):1051-8
references.pmid: 22419646
references.citation: Proc Biol Sci. 1998 May 7;265(1398):763-8
references.pmid: 9628035
references.citation: Semin Cell Dev Biol. 2015 Oct;46:82-90
references.pmid: 26456297
references.citation: BMC Physiol. 2009;9:11
references.pmid: 19545439
references.citation: Trends Parasitol. 2001 Apr;17(4):189-94
references.pmid: 11282509
references.citation: J Exp Biol. 2013 Mar 15;216(Pt 6):952-9
references.pmid: 23155090
references.citation: Am J Trop Med Hyg. 1971 Jul;20(4):642-5
references.pmid: 4398129
references.citation: J Exp Biol. 2011 Apr 1;214(Pt 7):1163-9
references.pmid: 21389202
references.citation: J Insect Physiol. 2001 Dec;47(12):1459-1465
references.pmid: 12770152