title: Dopamine modulation of spatial navigation memory in Parkinson's disease.
abstract: Striatal dopamine depletion is a key pathophysiological feature of Parkinson's disease (PD) causing motor and nonmotor symptoms. Research on nonmotor symptoms has mainly focused on frontostriatal functions. However, dopamine pathways ascending from the ventral tegmental area also innervate hippocampal structures and modulate hippocampal-dependent functions, such as spatial memory. Using a virtual spatial navigation task, we investigated dopaminergic modulation of spatial memory in PD patients in a crossover medication ON/OFF design. We examined medication effects on striatal- and hippocampal-dependent spatial memory by either replacing a location cue in the environment or enlarging its spatial boundary. Key results indicate that in contrast to prior evidence for younger adults, PD patients, like their age-matched controls, rely more on striatal cue-based than hippocampal spatial learning. Medication facilitated striatal-dependent cue-location learning, whereas medication benefit in hippocampal boundary-related spatial memory depended on prior experience with the task. Medication effects on spatial memory were comparable to and independent of benefits on motor symptoms. These findings shed new light on dopaminergic modulation of hippocampal-striatal functions in PD.
authors.affiliation: Chair of Lifespan Developmental Neuroscience, Department of Psychology, TU Dresden, Dresden, Germany. Electronic address: franka.thurm@tu-dresden.de.
authors.forename: Franka
authors.initials: F
authors.lastname: Thurm
authors.affiliation: Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
authors.forename: Nicolas W
authors.initials: NW
authors.lastname: Schuck
authors.affiliation: Division of Neurodegenerative Diseases, Department of Neurology, TU Dresden, Dresden, Germany.
authors.forename: Mareike
authors.initials: M
authors.lastname: Fauser
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
authors.forename: Christian F
authors.initials: CF
authors.lastname: Doeller
authors.affiliation: Institute of Clinical Psychology and Psychotherapy, Department of Psychology, TU Dresden, Dresden, Germany.
authors.forename: Yuliya
authors.initials: Y
authors.lastname: Stankevich
authors.affiliation: Institute of Clinical Psychology and Psychotherapy, Department of Psychology, TU Dresden, Dresden, Germany.
authors.forename: Ricarda
authors.initials: R
authors.lastname: Evens
authors.affiliation: Institute of Clinical Psychology and Psychotherapy, Department of Psychology, TU Dresden, Dresden, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Riedel
authors.affiliation: Division of Neurodegenerative Diseases, Department of Neurology, TU Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Storch
authors.affiliation: Institute of Clinical Psychology and Psychotherapy, Department of Psychology, TU Dresden, Dresden, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lueken
authors.affiliation: Chair of Lifespan Developmental Neuroscience, Department of Psychology, TU Dresden, Dresden, Germany; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany. Electronic address: shu-chen.li@tu-dresden.de.
authors.forename: Shu-Chen
authors.initials: SC
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000523:psychology; D003342:Corpus Striatum / Q000502:physiology; D003463:Cues; D004298:Dopamine / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D007858:Learning / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000523:psychology*; D065852:Spatial Memory / Q000187:drug effects*; D065854:Spatial Navigation / Q000187:drug effects*
chemical_list: D004298:Dopamine
keywords: Aging; Dopamine; Hippocampus; Parkinson's disease; Spatial navigation; Striatum