title: Sequential unusual site metastases in renal cell cancer: Saga of repeated tumor implantation and prolonged survival without systemic therapy.
abstract: Renal cell cancer (RCC) is known to produce metastasis to unusual sites both synchronously and metachronously several years after the primary treatment. We report a rare case of RCC with three different, sequential, and each time isolated rare site metastasis to ureteric stump, surgical site, and urinary bladder over a period of 6 years after radical nephrectomy. At each recurrence, metastasectomy was carried out and no systemic therapy was administered. Eleven years after radical nephrectomy and 5 years after last resection, the patient remains disease free. Multiple recurrences can occur in RCC and complete surgical resection results in disease free survival.
authors.affiliation: Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Siddharth
authors.initials: S
authors.lastname: Yadav
authors.affiliation: Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Rishi
authors.initials: R
authors.lastname: Nayyar
authors.affiliation: Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Amlesh
authors.initials: A
authors.lastname: Seth
keywords: Bladder renal cell cancer; metachronous metastasis; metastatectomy in renal cell cancer; renal cell cancer with rare site metastasis; ureteric renal cell cancer
references.citation: Ecancermedicalscience. 2010;4:175
references.pmid: 22276029
references.citation: World J Surg Oncol. 2005 Jul 20;3:48
references.pmid: 16029517
references.citation: Urology. 1994 Aug;44(2):278-81
references.pmid: 8048208
references.citation: Cancer. 1997 Dec 1;80(11):2167-74
references.pmid: 9392341
references.citation: World J Surg. 1999 Oct;23(10):989-95; discussion 996-7
references.pmid: 10512937
references.citation: J Natl Cancer Inst. 1987 Feb;78(2):377-85
references.pmid: 3468299
references.citation: Urology. 2002 Nov;60(5):911-2
references.pmid: 12429329