title: Infection Prevention in Transplantation.
abstract: The number of patients undergoing hematopoietic cell and solid organ transplantation are increasing every year, as are the number of centers both transplanting and caring for these patients. Improvements in transplant procedures, immunosuppressive regimens, and prevention of transplant-associated complications have led to marked improvements in survival in both populations. Infections remain one of the most important sources of excess morbidity and mortality in transplant, and therefore, infection prevention strategies are a critical element for avoiding these complications in centers caring for high-risk patients. This manuscript aims to provide an update of recent data on prevention of major healthcare-associated infections unique to transplantation, reviews the emergence of antimicrobial resistant infections, and discusses updated strategies to both identify and prevent transmission of these pathogens in transplant recipients.
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, E4-100, Seattle, WA, 98109, USA. spergam@fredhutch.org.|Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, E4-100, Seattle, WA, 98109, USA. spergam@fredhutch.org.|Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA. spergam@fredhutch.org.|Infection Prevention, Seattle Cancer Care Alliance, Seattle, WA, USA. spergam@fredhutch.org.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Pergam
keywords: Clostridium difficile; Filamentous mold; Fungus; Hand hygiene; Infection control; Infection prevention; MRSA; Measles; Respiratory viruses; Screening; Transplant; VRE; Vaccines
references.citation: Am J Infect Control. 2015 Sep 1;43(9):1023
references.pmid: 26095655
references.citation: Biol Blood Marrow Transplant. 2015 Apr;21(4):772-4
references.pmid: 25598276
references.citation: Am J Infect Control. 2014 May;42(5):472-8
references.pmid: 24773785
references.citation: Am J Infect Control. 2015 Jan;43(1):89-91
references.pmid: 25564131
references.citation: Transpl Infect Dis. 2015 Aug;17(4):558-65
references.pmid: 25953418
references.citation: PLoS One. 2014 Jan 22;9(1):e85210
references.pmid: 24465506
references.citation: Antimicrob Resist Infect Control. 2014 Dec 01;3(1):37
references.pmid: 25671098
references.citation: MMWR Morb Mortal Wkly Rep. 2014 Dec 5;63(48):1129-32
references.pmid: 25474033
references.citation: J Med Microbiol. 2015 Feb;64(Pt 2):191-4
references.pmid: 25627208
references.citation: Clin Infect Dis. 2015 Mar 15;60(6):881-8
references.pmid: 25572899
references.citation: Liver Transpl. 2016 Feb;22(2):201-8
references.pmid: 26335577
references.citation: Ann Intern Med. 2015 May 5;162(9):655-6
references.pmid: 25751746
references.citation: JAMA Pediatr. 2015 Sep;169(9):815-21
references.pmid: 26146908
references.citation: N Engl J Med. 2013 Feb 7;368(6):533-42
references.pmid: 23388005
references.citation: Transplant Proc. 2014 Jul-Aug;46(6):1753-6
references.pmid: 25131028
references.citation: Am J Infect Control. 2015 Oct 1;43(10):1066-9
references.pmid: 26164767
references.citation: Clin Infect Dis. 2014 May;58(9):1274-83
references.pmid: 24463280
references.citation: J Clin Virol. 2014 Nov;61(3):329-33
references.pmid: 25171964
references.citation: Blood. 2015 Mar 12;125(11):1724-9
references.pmid: 25593338
references.citation: Vaccine. 2015 Mar 17;33(12):1440-5
references.pmid: 25665961
references.citation: PLoS One. 2015 Apr 02;10(4):e0123706
references.pmid: 25835018
references.citation: Pediatr Blood Cancer. 2014 Feb;61(2):276-80
references.pmid: 23970381
references.citation: Clin Infect Dis. 2015 Jul 15;61(2):192-202
references.pmid: 25847977
references.citation: Blood. 2010 Feb 18;115(7):1331-42
references.pmid: 20009037
references.citation: Transpl Infect Dis. 2007 Dec;9(4):265-9
references.pmid: 17511822
references.citation: J Hosp Infect. 2015 Jul;90(3):220-5
references.pmid: 25929790
references.citation: Biol Blood Marrow Transplant. 2009 Oct;15(10):1143-238
references.pmid: 19747629
references.citation: Am J Infect Control. 2015 Mar 1;43(3):228-33
references.pmid: 25728148
references.citation: Am J Transplant. 2014 Feb;14(2):477-80
references.pmid: 24433460
references.citation: Clin Infect Dis. 2014 Nov 15;59 Suppl 5:S352-5
references.pmid: 25352630
references.citation: Korean J Intern Med. 2015 Sep;30(5):694-704
references.pmid: 26354064
references.citation: Antimicrob Resist Infect Control. 2015 Oct 14;4:41
references.pmid: 26473030
references.citation: Liver Transpl. 2015 Dec;21(12):1511-9
references.pmid: 26136397
references.citation: Infect Control Hosp Epidemiol. 2015 Dec;36(12):1401-8
references.pmid: 26394849
references.citation: J Hosp Infect. 2014 Sep;88(1):48-51
references.pmid: 25063013
references.citation: Clin Infect Dis. 2015 Mar 1;60(5):729-37
references.pmid: 25371488
references.citation: Am J Infect Control. 2015 Dec 1;43(12):1350-3
references.pmid: 26362699
references.citation: Infect Control Hosp Epidemiol. 2014 Nov;35(11):1336-41
references.pmid: 25333427
references.citation: Infect Control Hosp Epidemiol. 2013 May;34(5):507-13
references.pmid: 23571368
references.citation: Biol Blood Marrow Transplant. 2014 Jun;20(6):844-51
references.pmid: 24607551
references.citation: Am J Transplant. 2015 Jan;15(1):5-6
references.pmid: 25510898
references.citation: Clin Ther. 2015 Jul 1;37(7):1443-1453.e2
references.pmid: 25982687
references.citation: Am J Transplant. 2015 Sep;15(9):2470-4
references.pmid: 25943587
references.citation: PLoS One. 2015 Apr 17;10(4):e0124483
references.pmid: 25886133
references.citation: Clin Infect Dis. 2014 Nov 15;59 Suppl 5:S344-51
references.pmid: 25352629
references.citation: Infect Control Hosp Epidemiol. 2015 Dec;36(12):1461-3
references.pmid: 26329908
references.citation: Transpl Infect Dis. 2014 Feb;16(1):84-9
references.pmid: 24330161
references.citation: PLoS One. 2011;6(11):e27483
references.pmid: 22096580
references.citation: Biol Blood Marrow Transplant. 2010 Nov;16(11):1576-81
references.pmid: 20685257
references.citation: Eur J Clin Microbiol Infect Dis. 2014 Jun;33(6):1053-61
references.pmid: 24500598
references.citation: PLoS One. 2015 Oct 02;10(10):e0139883
references.pmid: 26431402
references.citation: Am J Transplant. 2015 Jul;15(7):1874-81
references.pmid: 25788003
references.citation: Am J Transplant. 2014 Aug;14(8):1887-94
references.pmid: 25040438
references.citation: Clin Infect Dis. 2012 Sep;55(6):764-70
references.pmid: 22693346
references.citation: Infect Control Hosp Epidemiol. 2011 May;32(5):490-6
references.pmid: 21515980
references.citation: Leuk Lymphoma. 2016;57(3):623-7
references.pmid: 26122193
references.citation: Clin Infect Dis. 2014 Feb;58(3):e44-100
references.pmid: 24311479
references.citation: Clin Infect Dis. 2015 Aug 1;61(3):433-44
references.pmid: 25870328
references.citation: Am J Infect Control. 2013 Jun;41(6):503-8
references.pmid: 23337306
references.citation: PLoS One. 2014 Mar 24;9(3):e90158
references.pmid: 24662889
references.citation: Infect Control Hosp Epidemiol. 2006 Feb;27(2):122-6
references.pmid: 16465627
references.citation: Am J Transplant. 2015 Apr;15(4):1021-7
references.pmid: 25676738
references.citation: Bone Marrow Transplant. 2007 May;39(10):623-9
references.pmid: 17384657
references.citation: Biol Blood Marrow Transplant. 2014 Sep;20(9):1329-34
references.pmid: 24792871
references.citation: Biol Blood Marrow Transplant. 2015 Dec;21(12):2160-2166
references.pmid: 26271191
references.citation: J Clin Virol. 2014 Apr;59(4):213-7
references.pmid: 24495848
references.citation: J Hosp Infect. 2015 Nov;91(3):244-9
references.pmid: 26341270
references.citation: Eur J Haematol. 2016 Jul;97(1):70-7
references.pmid: 26380877
references.citation: Am J Transplant. 2013 Mar;13 Suppl 4:50-8
references.pmid: 23464998
references.citation: Biol Blood Marrow Transplant. 2016 Jan;22(1):157-63
references.pmid: 26211988
references.citation: J Virol. 2014 Dec;88(24):14184-96
references.pmid: 25275120
references.citation: PLoS One. 2015 Aug 03;10(8):e0134737
references.pmid: 26237422
references.citation: Transpl Infect Dis. 2015 Dec;17(6):785-94
references.pmid: 26284461
references.citation: Am J Transplant. 2015 Apr;15(4):1101-4
references.pmid: 25716741