title: Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping.
abstract: Quantitative susceptibility mapping is useful for assessing iron deposition in the substantia nigra of patients with Parkinson disease. We aimed to determine whether quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference in iron deposits in the substantia nigra of patients with Parkinson disease.
  
  
  
  Our study population comprised 24 patients with Parkinson disease and 24 age- and sex-matched healthy controls. They underwent 3T MR imaging by using a 3D multiecho gradient-echo sequence. On reconstructed quantitative susceptibility mapping, we measured the susceptibility values in the anterior, middle, and posterior parts of the substantia nigra, the whole substantia nigra, and other deep gray matter structures in both hemibrains. To identify the more and less affected hemibrains in patients with Parkinson disease, we assessed the severity of movement symptoms for each hemibrain by using the Unified Parkinson's Disease Rating Scale.
  
  
  
  In the posterior substantia nigra of patients with Parkinson disease, the mean susceptibility value was significantly higher in the more than the less affected hemibrain substantia nigra (P < .05). This value was significantly higher in both the more and less affected hemibrains of patients with Parkinson disease than in controls (P < .05). Asymmetry of the mean susceptibility values was significantly greater for patients than controls (P < .05). Receiver operating characteristic analysis showed that quantitative susceptibility mapping of the posterior substantia nigra in the more affected hemibrain provided the highest power for discriminating patients with Parkinson disease from the controls.
  
  
  
  Quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with Parkinson disease.
authors.affiliation: From the Departments of Diagnostic Radiology (M.A., M.T., Y.I., M.K., Y.Y.) coralcommunity@yahoo.co.jp.
authors.forename: M
authors.identifier: 0000-0002-4837-4197
authors.initials: M
authors.lastname: Azuma
authors.affiliation: Department of Radiology (T.H.), Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
authors.forename: T
authors.identifier: 0000-0003-1480-2197
authors.initials: T
authors.lastname: Hirai
authors.affiliation: Neurosurgery (K.Y.).
authors.forename: K
authors.identifier: 0000-0001-0311-5466
authors.initials: K
authors.lastname: Yamada
authors.affiliation: Neurology (S.Y., Y.A.), Graduate School of Medical Sciences.
authors.forename: S
authors.identifier: 0000-0001-9315-3492
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Neurology (S.Y., Y.A.), Graduate School of Medical Sciences.
authors.forename: Y
authors.identifier: 0000-0001-7115-9105
authors.initials: Y
authors.lastname: Ando
authors.affiliation: From the Departments of Diagnostic Radiology (M.A., M.T., Y.I., M.K., Y.Y.).
authors.forename: M
authors.identifier: 0000-0002-9586-8341
authors.initials: M
authors.lastname: Tateishi
authors.affiliation: From the Departments of Diagnostic Radiology (M.A., M.T., Y.I., M.K., Y.Y.).
authors.forename: Y
authors.identifier: 0000-0001-9488-8781
authors.initials: Y
authors.lastname: Iryo
authors.affiliation: Department of Medical Physics in Advanced Biomedical Sciences (T.Y.), Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: T
authors.identifier: 0000-0002-7941-637X
authors.initials: T
authors.lastname: Yoneda
authors.affiliation: From the Departments of Diagnostic Radiology (M.A., M.T., Y.I., M.K., Y.Y.).
authors.forename: M
authors.identifier: 0000-0002-6869-3638
authors.initials: M
authors.lastname: Kitajima
authors.affiliation: Department of Radiology (Y.W.), Weill Cornell Medical College, New York, New York.
authors.forename: Y
authors.identifier: 0000-0003-1404-8526
authors.initials: Y
authors.lastname: Wang
authors.affiliation: From the Departments of Diagnostic Radiology (M.A., M.T., Y.I., M.K., Y.Y.).
authors.forename: Y
authors.identifier: 0000-0002-2905-1093
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D000368:Aged; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007501:Iron / Q000032:analysis*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D012372:ROC Curve; D013378:Substantia Nigra / Q000737:chemistry / Q000000981:diagnostic imaging*
chemical_list: D007501:Iron
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