title: 2015 Russell Ross Memorial Lecture in Vascular Biology: Protective Autoimmunity in Atherosclerosis.
abstract: Atherosclerosis is an inflammatory disease of the arterial wall. It is accompanied by an autoimmune response against apolipoprotein B-100, the core protein of low-density lipoprotein, which manifests as CD4 T cell and antibody responses. To assess the role of the autoimmune response in atherosclerosis, the nature of the CD4 T cell response against apolipoprotein B-100 was studied with and without vaccination with major histocompatibility complex-II-restricted apolipoprotein B-100 peptides. The immunologic basis of autoimmunity in atherosclerosis is discussed in the framework of theories of adaptive immunity. Older vaccination approaches are also discussed. Vaccinating Apoe(-/-) mice with major histocompatibility complex-II-restricted apolipoprotein B-100 peptides reduces atheroma burden in the aorta by ≈40%. The protective mechanism likely includes secretion of interleukin-10. Protective autoimmunity limits atherosclerosis in mice and suggests potential for developing preventative and therapeutic vaccines for humans.
authors.affiliation: From the La Jolla Institute for Allergy & Immunology and Department of Bioengineering, UCSD, La Jolla, CA.
authors.forename: Klaus
authors.initials: K
authors.lastname: Ley
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D053299:Apolipoprotein B-100 / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism; D001324:Autoantigens / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D008822:Mice, Transgenic; D065840:Protective Factors; D012307:Risk Factors; D022223:Vaccines, Subunit / Q000008:administration & dosage
chemical_list: D053299:Apolipoprotein B-100; D001057:Apolipoproteins E; D001323:Autoantibodies; D001324:Autoantigens; D022223:Vaccines, Subunit
keywords: apolipoprotein B; atherosclerosis; immune system; immunology; lymphocyte
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