title: Antioxidant activity of linalool in patients with carpal tunnel syndrome.
abstract: BACKGROUND
  Carpal tunnel syndrome (CTS) is a common peripheral neuropathy and ischemic-reperfusion injury. Oxidative stress is considered a major cause of CTS. Linalool, a component of essential oils, has antioxidant activity. This study was designed to determine the effects of linalool inhalation on oxidative stress in patients with CTS.
  
  
  METHODS
  This double-blind, placebo-controlled study assessed the effects of linalool inhalation on oxidative stress in patients with CTS. Thirty-seven subjects, with and without CTS, were randomized to inhalation of 1% linalool or carrier oil. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, systolic blood pressure (sBP), diastolic blood pressure (dBP) and pulse rate were analyzed.
  
  
  RESULTS
  DPPH inhibition was significantly higher in both experimental groups than in their respective controls. Moreover inhalation of linalool reduced sBP, dBP and pulse rate in the CTS group, and pulse rate in the non-CTS group. However, there were no significant differences among the study groups in nitrite levels, sBP, dBP and pulse rate.
  
  
  CONCLUSIONS
  Inhalation of linalool increases antioxidative activity and reduces blood pressure and pulse rate in patients with CTS.
authors.affiliation: Department of Basic Nursing Science, School of Nursing, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
authors.forename: Geun-Hye
authors.initials: GH
authors.lastname: Seol
authors.affiliation: Department of Basic Nursing Science, School of Nursing, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
authors.forename: Purum
authors.initials: P
authors.lastname: Kang
authors.affiliation: Department of Basic Nursing Science, School of Nursing, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
authors.forename: Hui Su
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Basic Nursing Science, School of Nursing, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. ghseol@korea.ac.kr.
authors.forename: Geun Hee
authors.initials: GH
authors.lastname: Seol
mesh_terms: D000080462:Acyclic Monoterpenes; D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002349:Carpal Tunnel Syndrome / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D039821:Monoterpenes / Q000627:therapeutic use*
chemical_list: D000080462:Acyclic Monoterpenes; D000975:Antioxidants; D039821:Monoterpenes; C018584:linalool
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