title: Simultaneous T1and T2Brain Relaxometry in Asymptomatic Volunteers using Magnetic Resonance Fingerprinting.
abstract: Magnetic resonance fingerprinting (MRF) is a method of image acquisition that produces multiple MR parametric maps from a single scan. Here, we describe the normal range and progression of MRF-derived relaxometry values with age in healthy individuals. 56 normal volunteers (ages 11-71 years, M:F 24:32) were scanned. Regions of interest were drawn on T1and T2maps in 38 areas, including lobar and deep white matter, deep gray nuclei, thalami and posterior fossa structures. Relaxometry differences were assessed using a forward stepwise selection of a baseline model including either gender, age, or both, where variables were included if they contributed significantly (p<0.05). Additionally, differences in regional anatomy, including comparisons between hemispheres and between anatomical subcomponents, were assessed by paired t-tests. Using this protocol, MRF-derived T1and T2in frontal WM regions were found to increase in with age, while occipital and temporal regions remained relatively stable. Deep gray nuclei, including substantia nigra, were found to have age-related decreases in relaxometry. Gender differences were observed in T1and T2of temporal regions, cerebellum and pons. Males were also found to have more rapid age-related changes in frontal and parietal WM. Regional differences were identified between hemispheres, between genu and splenium of corpus callosum, and between posteromedial and anterolateral thalami. In conclusion, MRF quantification can measure relaxometry trends in healthy individuals that are in agreement with current understanding of neuroanatomy and neurobiology, and has the ability to uncover additional patterns that have not yet been explored.
authors.affiliation: Department of Radiology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: Chaitra
authors.initials: C
authors.lastname: Badve
authors.affiliation: School of Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: Alice
authors.initials: A
authors.lastname: Yu
authors.affiliation: School of Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Rogers
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Ma
authors.affiliation: Biostatistics and Bioinformatics Core, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: Yiying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Biostatistics and Bioinformatics Core, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Schluchter
authors.affiliation: Department of Radiology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Sunshine
authors.affiliation: Department of Radiology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA; Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Griswold
authors.affiliation: Department of Radiology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA; Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Gulani
keywords: MR Fingerprinting; T1 mapping; T2 mapping; aging; relaxometry
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