title: Pyridoxine hydroxamic acids as novel HIV-integrase inhibitors.
abstract: A series of pyridoxine hydroxamic acid analog bearing a 5-aryl-spacers were synthesized. Evaluation of these novel HIV integrase complex inhibitors revealed compounds with high potency against wild-type HIV virus.
authors.affiliation: Ambrilia Biopharma Inc., 1000 Ch. du Golf, Verdun, Montreal, QC H4P 2R2, Canada.
authors.forename: Brent R
authors.initials: BR
authors.lastname: Stranix
authors.affiliation: Ambrilia Biopharma Inc., 1000 Ch. du Golf, Verdun, Montreal, QC H4P 2R2, Canada.
authors.forename: Jinzi J
authors.initials: JJ
authors.lastname: Wu
authors.affiliation: Ambrilia Biopharma Inc., 1000 Ch. du Golf, Verdun, Montreal, QC H4P 2R2, Canada.
authors.forename: Guy
authors.initials: G
authors.lastname: Milot
authors.affiliation: Ambrilia Biopharma Inc., 1000 Ch. du Golf, Verdun, Montreal, QC H4P 2R2, Canada.
authors.forename: Françis
authors.initials: F
authors.lastname: Beaulieu
authors.affiliation: Ambrilia Biopharma Inc., 1000 Ch. du Golf, Verdun, Montreal, QC H4P 2R2, Canada.
authors.forename: Jean-Emanuel
authors.initials: JE
authors.lastname: Bouchard
authors.affiliation: Ambrilia Biopharma Inc., 1000 Ch. du Golf, Verdun, Montreal, QC H4P 2R2, Canada.
authors.forename: Kristine
authors.initials: K
authors.lastname: Gouveia
authors.affiliation: Ambrilia Biopharma Inc., 1000 Ch. du Golf, Verdun, Montreal, QC H4P 2R2, Canada.
authors.forename: André
authors.initials: A
authors.lastname: Forte
authors.affiliation: Ambrilia Biopharma Inc., 1000 Ch. du Golf, Verdun, Montreal, QC H4P 2R2, Canada.
authors.forename: Seema
authors.initials: S
authors.lastname: Garde
authors.affiliation: Ambrilia Biopharma Inc., 1000 Ch. du Golf, Verdun, Montreal, QC H4P 2R2, Canada.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: BPA, ENS de Cachan, CNRS, Cachan, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mouscadet
authors.affiliation: BPA, ENS de Cachan, CNRS, Cachan, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Delelis
authors.affiliation: Ambrilia Biopharma Inc., 1000 Ch. du Golf, Verdun, Montreal, QC H4P 2R2, Canada.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000818:Animals; D020134:Catalytic Domain; D005260:Female; D019427:HIV Integrase / Q000737:chemistry* / Q000378:metabolism; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D015497:HIV-1 / Q000502:physiology*; D006207:Half-Life; D006801:Humans; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D020128:Inhibitory Concentration 50; D011736:Pyridoxine / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019428:HIV Integrase Inhibitors; D006877:Hydroxamic Acids; D019427:HIV Integrase; D011736:Pyridoxine
keywords: Active site binding; HIV integrase inhibitor; Hydroxamic acid; Pyridoxine