title: The Cholinergic Potential, the Vagus Nerve and Challenges in Treatment of Traumatic Brain Injury.
abstract: Existing treatments of traumatic brain injury (TBI) have failed to reverse tremendous losses in productivity, independence and overall quality of life among TBI victims and therefore, cannot be viewed as sufficient. Although there is no shortage of promising basic concepts that may translate to efficacious therapies after TBI, the accumulated knowledge has yet to deliver treatments that adequately meet clinical and social demands. In this article, we discuss novel concepts, recent advances and accompanying challenges in developing cholinergic and related therapies after TBI.
authors.affiliation: University of North Texas Health Science Center, Institute for Healthy Aging, Center for Neuroscience Discovery, Fort Worth, TX 76248, USA. Victor.Uteshev@unthsc.edu.
authors.forename: Victor V
authors.initials: VV
authors.lastname: Uteshev
authors.forename: Olli
authors.initials: O
authors.lastname: Tenovuo
authors.forename: Nikhil
authors.initials: N
authors.lastname: Gaidhani
mesh_terms: D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000188:drug therapy*; D018678:Cholinergic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology; D064569:alpha7 Nicotinic Acetylcholine Receptor / Q000819:agonists
chemical_list: D018678:Cholinergic Agents; D064569:alpha7 Nicotinic Acetylcholine Receptor