title: A population-based study of aerococcal bacteraemia in the MALDI-TOF MS-era.
abstract: The purpose of this study was to determine the incidence of aerococcal bacteraemia in the MALDI-TOF MS-era, to describe the clinical presentation and to determine the MIC values of aerococci for ten antibiotics. Aerococci in blood cultures were identified through searches in the laboratory database for the years 2012-2014. MALDI-TOF MS, sequencing of the 16S rRNA gene and a PYR test were used for species identification. Patients' medical charts were systematically reviewed. Etests were used to determine MIC values. Seventy-seven patients were identified (Aerococcus urinae n = 49, Aerococcus viridans n = 14, Aerococcus sanguinicola n = 13 and Aerococcus christensenii n = 1) corresponding to incidences of 14 cases per 1,000,000 inhabitants per year (A. urinae) and 3.5 cases per 1,000,000 inhabitants per year (A. sanguinicola and A.viridans). A. urinae was in pure culture in 61 %, A. sanguinicola in 46 % and A. viridans in 36 % of the cases. The A. urinae and A. sanguinicola patients were old and many had urinary tract disorders, and a majority had a suspected urinary tract focus of the bacteraemia. Eighty percent of the A. urinae patients were men. Five A. urinae patients were diagnosed with infective endocarditis. Six patients died within 30 days. Most isolates had low MICs to penicillins and carbapenems. MALDI-TOF MS has led to an increased identification of aerococcal bacteremia. A. urinae remains the most common Aerococcus in blood cultures and in aerococcal IE.
authors.affiliation: Clinical Microbiology, Lund, Region Skåne, Sweden. erik.senneby@med.lu.se.|Department of Clinical Sciences, Division of Infection Medicine, Lund University, Tornavägen 10, 221 84, Lund, Sweden. erik.senneby@med.lu.se.
authors.forename: E
authors.identifier: http://orcid.org/0000-0002-5756-2552
authors.initials: E
authors.lastname: Senneby
authors.affiliation: Department of Clinical Sciences, Division of Infection Medicine, Lund University, Tornavägen 10, 221 84, Lund, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Göransson
authors.affiliation: Department of Clinical Sciences, Division of Infection Medicine, Lund University, Tornavägen 10, 221 84, Lund, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Weiber
authors.affiliation: Department of Clinical Sciences, Division of Infection Medicine, Lund University, Tornavägen 10, 221 84, Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Rasmussen
mesh_terms: D000293:Adolescent; D000328:Adult; D056570:Aerococcus / Q000145:classification* / Q000187:drug effects; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009026:Mortality; D011159:Population Surveillance; D012189:Retrospective Studies; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
references.citation: Infection. 2002 Oct;30(5):310-3
references.pmid: 12382093
references.citation: APMIS. 1989 Jun;97(6):539-46
references.pmid: 2736106
references.citation: Int J Syst Bacteriol. 1999 Jul;49 Pt 3:1125-8
references.pmid: 10425770
references.citation: J Clin Microbiol. 2013 Apr;51(4):1303-4
references.pmid: 23390276
references.citation: Turk Kardiyol Dern Ars. 2012 Jan;40(1):112
references.pmid: 22395391
references.citation: Clin Microbiol Infect. 2016 Jan;22(1):e1-e2
references.pmid: 26363405
references.citation: J Clin Microbiol. 2014 Jun;52(6):2177-80
references.pmid: 24671781
references.citation: Open Forum Infect Dis. 2014 May 23;1(1):ofu025
references.pmid: 25734098
references.citation: Infection. 2016 Apr;44(2):167-73
references.pmid: 26119199
references.citation: J Clin Microbiol. 2010 May;48(5):1549-54
references.pmid: 20220166
references.citation: Scand J Infect Dis. 2010 Oct;42(10):775-80
references.pmid: 20482457
references.citation: South Med J. 2014 Oct;107(10):642-7
references.pmid: 25279869
references.citation: J Infect. 2013 Jun;66(6):467-74
references.pmid: 23277106
references.citation: Am J Med. 1994 Mar;96(3):200-9
references.pmid: 8154507
references.citation: Antimicrob Agents Chemother. 2011 Jan;55(1):451-2
references.pmid: 21078934
references.citation: Int J Syst Evol Microbiol. 2007 Jun;57(Pt 6):1291-4
references.pmid: 17551045
references.citation: J Gen Microbiol. 1953 Jun;8(3):475-80
references.pmid: 13061751
references.citation: New Microbiol. 2014 Oct;37(4):563-6
references.pmid: 25387295
references.citation: Clin Infect Dis. 1995 Oct;21(4):943-7
references.pmid: 8645844
references.citation: J Clin Microbiol. 1998 Oct;36(10):2810-6
references.pmid: 9738025
references.citation: Clin Microbiol Infect. 2016 Jan;22(1):22-27
references.pmid: 26454061
references.citation: Can J Infect Dis Med Microbiol. 2014 Jul;25(4):232
references.pmid: 25285132
references.citation: J Clin Microbiol. 2010 Sep;48(9):3445-7
references.pmid: 20660216
references.citation: Clin Microbiol Infect. 2012 Jun;18(6):546-50
references.pmid: 21895858
references.citation: J Antimicrob Chemother. 2001 Nov;48(5):653-8
references.pmid: 11679554
references.citation: J Clin Microbiol. 2010 Sep;48(9):3435-7
references.pmid: 20592151
references.citation: J Clin Microbiol. 2012 May;50(5):1787-91
references.pmid: 22403420
references.citation: J Clin Microbiol. 2003 Jun;41(6):2587-92
references.pmid: 12791884
references.citation: Clin Infect Dis. 1995 Oct;21(4):891-6
references.pmid: 8645836
references.citation: Diagn Microbiol Infect Dis. 2015 Feb;81(2):149-51
references.pmid: 25497460
references.citation: Scand J Infect Dis. 2008;40(9):761-5
references.pmid: 19086249
references.citation: Open Microbiol J. 2016 Mar 10;10:27-31
references.pmid: 27014376