title: Advances in the surface modification techniques of bone-related implants for last 10 years.
abstract: At the time of implanting bone-related implants into human body, a variety of biological responses to the material surface occur with respect to surface chemistry and physical state. The commonly used biomaterials (e.g. titanium and its alloy, Co-Cr alloy, stainless steel, polyetheretherketone, ultra-high molecular weight polyethylene and various calcium phosphates) have many drawbacks such as lack of biocompatibility and improper mechanical properties. As surface modification is very promising technology to overcome such problems, a variety of surface modification techniques have been being investigated. This review paper covers recent advances in surface modification techniques of bone-related materials including physicochemical coating, radiation grafting, plasma surface engineering, ion beam processing and surface patterning techniques. The contents are organized with different types of techniques to applicable materials, and typical examples are also described.
authors.affiliation: Institute for Regenerative Medicine and Biomimetic Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China, Beijing Allgens Medical Science and Technology Co., Ltd, Beijing 100176, China, Bio-X Center, School of Life Science, Zhejiang Sci-Tech University, Hangzhou 310018, China, and Institute of Natural Sciences, Yonsei University, Seoul 120-749, Korea.
authors.forename: Zhi-Ye
authors.initials: ZY
authors.lastname: Qiu
authors.affiliation: Institute for Regenerative Medicine and Biomimetic Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China, Beijing Allgens Medical Science and Technology Co., Ltd, Beijing 100176, China, Bio-X Center, School of Life Science, Zhejiang Sci-Tech University, Hangzhou 310018, China, and Institute of Natural Sciences, Yonsei University, Seoul 120-749, Korea.
authors.forename: Cen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Institute for Regenerative Medicine and Biomimetic Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China, Beijing Allgens Medical Science and Technology Co., Ltd, Beijing 100176, China, Bio-X Center, School of Life Science, Zhejiang Sci-Tech University, Hangzhou 310018, China, and Institute of Natural Sciences, Yonsei University, Seoul 120-749, Korea.
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Wang
authors.affiliation: Institute for Regenerative Medicine and Biomimetic Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China, Beijing Allgens Medical Science and Technology Co., Ltd, Beijing 100176, China, Bio-X Center, School of Life Science, Zhejiang Sci-Tech University, Hangzhou 310018, China, and Institute of Natural Sciences, Yonsei University, Seoul 120-749, Korea.
authors.forename: In-Seop
authors.initials: IS
authors.lastname: Lee
keywords: bone-related materials; ion beam processing; physicochemical coating; plasma surface engineering; radiation grafting; surface modification; surface patterning
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