title: Ramping up degradation for proliferation.
abstract: The control of proteasome-mediated protein degradation is thought to occur mainly at the level of polyubiquitylation of the substrate. However, the proteasome can also be regulated directly, as now demonstrated by a study in which DYRK2-mediated phosphorylation of the 19S subunit Rpt3 is found to increase proteasome activity.
authors.affiliation: Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Jon M
authors.initials: JM
authors.lastname: Huibregtse
authors.affiliation: Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Matouschek
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology*; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D005260:Female; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*
chemical_list: D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D046988:Proteasome Endopeptidase Complex
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