title: Cytokines of the LIF/CNTF family and metabolism.
abstract: The incidence of obesity is increasing worldwide. Obesity is accompanied by a chronic inflammatory state that increases the risk of metabolic diseases such as insulin-resistance and type 2 diabetes. Over the past two decades, interest in immunomodulatory cytokines as potential mediators and/or targets for treatment or prevention of obesity and metabolic syndrome has increased. In this review, we summarize studies that revealed the effects of LIF family cytokines on adipose tissue, energy expenditure and food intake, highlighting the importance of gp130/LIFRβ signaling in obesity and obesity-related metabolic diseases.
authors.affiliation: Département de Pharmacologie, Université de Montréal, 2900 Édouard Montpetit, Montreal, QC H3T 1J4, Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Pasquin
authors.affiliation: Renal Division, KCVA Medical Center, 4801 Linwood Blvd, Kansas City, MO 64128, USA.
authors.forename: Mukut
authors.initials: M
authors.lastname: Sharma
authors.affiliation: Département de Pharmacologie, Université de Montréal, 2900 Édouard Montpetit, Montreal, QC H3T 1J4, Canada. Electronic address: jf.gauchat@umontreal.ca.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Gauchat
mesh_terms: D000818:Animals; D020934:Ciliary Neurotrophic Factor / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology* / Q000473:pathology; D006801:Humans; D053605:Leukemia Inhibitory Factor / Q000276:immunology*; D024821:Metabolic Syndrome / Q000276:immunology* / Q000473:pathology; D009765:Obesity / Q000276:immunology* / Q000473:pathology; D012307:Risk Factors
chemical_list: D020934:Ciliary Neurotrophic Factor; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor
keywords: Cytokines; Leukemia inhibitory factor; Metabolism; Obesity; gp130