title: Is sEHi lowering LDL-C by reducing expression of PCSK9 through SREBP2 pathway?
authors.affiliation: Department of Cardiology, Internal Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Internal Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Internal Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
authors.forename: Ya-jun
authors.initials: YJ
authors.lastname: Gui
authors.affiliation: Department of Cardiology, Internal Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
authors.forename: Cai-xiu
authors.initials: CX
authors.lastname: Liao
authors.affiliation: Department of Cardiology, Internal Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, PR China. Electronic address: xudanyan02@sina.com.
authors.forename: Dan-yan
authors.initials: DY
authors.lastname: Xu
mesh_terms: D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D005786:Gene Expression Regulation; D006801:Humans; D000091362:PCSK9 Inhibitors; D000071449:Proprotein Convertase 9 / Q000096:biosynthesis*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D051782:Sterol Regulatory Element Binding Protein 2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C524106:4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid; D001565:Benzoates; D008078:Cholesterol, LDL; D000091362:PCSK9 Inhibitors; C497390:SREBF2 protein, human; D051782:Sterol Regulatory Element Binding Protein 2; D014508:Urea; C472125:PCSK9 protein, human; D000071449:Proprotein Convertase 9
keywords: EETs; LDL-C; PCSK9; SREBP2; sEHi