title: Clear Cell Tumors of Soft Tissue.
abstract: Clear cell lesions of soft tissue include varying morphologic patterns and a range of clinical behaviors and prognoses. Benign lesions include perivascular epithelioid cell tumors, clear cell fibrous papule, and distinctive dermal clear cell mesenchymal tumor; malignant tumors include clear cell sarcoma, liposarcoma, and rare malignant perivascular epithelioid cell tumors. Clear cell variants of other benign and malignant soft tissue tumors include fibrous histiocytoma, atypical fibroxanthoma, myoepithelioma, leiomyoma and leiomyosarcoma, and rhabdomyosarcoma. Metastatic clear cell tumors, including renal cell carcinoma and adrenal cortical carcinoma, should be considered in the differential diagnosis and excluded through clinical history, imaging studies, and immunohistochemical stains.
authors.affiliation: Department of Pathology, Joint Pathology Center, 606 Stephen Sitter Avenue, Silver Spring, MD 20910, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Auerbach
authors.affiliation: Department of Pathology, Sunset Medical Center, Southern California Permanente Medical Group, 4867 Sunset Boulevard, 2nd floor, Los Angeles, CA 90027, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Cassarino