title: Chronic Hypersensitivity Pneumonitis With a Usual Interstitial Pneumonia-Like Pattern: Correlation Between Histopathologic and Clinical Findings.
abstract: Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by the inhalation of environmental antigens. The relationship between clinical, radiologic, and histopathologic findings of chronic HP remains unclear.
  
  
  
  Sixteen patients with proven chronic bird-related HP with a usual interstitial pneumonia-like pattern were analyzed retrospectively. Histopathologic findings were semiquantitatively assessed and compared with clinical and radiologic findings. We also evaluated the histopathologic findings affecting prognosis.
  
  
  
  The extent of centrilobular fibrosis was negatively correlated with Pao2 (r = -0.55, P = .03). The extent of bridging fibrosis was positively correlated with the ratio of maximal expiratory flow at 50% of forced vital capacity to that at 25% (r = 0.60, P = .02). Patients with a greater extent of fibroblastic foci (FF) had more radiologic reticulation (P = .01), honeycombing (P = .01), and traction bronchiectasis (P = .02), and had significantly shorter survival time (P = .01) than patients with a lesser extent of FF. Multivariate analysis showed that the extent of FF was a significant prognostic factor (hazard ratio, 2.36; 95% confidence interval, 1.02-5.48; P = .04).
  
  
  
  Our findings demonstrated that the extent of FF was significantly associated with reticulation, honeycombing, and traction bronchiectasis on high-resolution CT scanning. Moreover, the extent of FF could be a useful predictor of mortality in chronic HP with a usual interstitial pneumonia-like pattern.
authors.affiliation: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Sahoko
authors.initials: S
authors.lastname: Chiba
authors.affiliation: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: tsuchiya.pulm@tmd.ac.jp.
authors.forename: Kimitake
authors.initials: K
authors.lastname: Tsuchiya
authors.affiliation: Department of Pathology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Akashi
authors.affiliation: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ishizuka
authors.affiliation: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Okamoto
authors.affiliation: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Furusawa
authors.affiliation: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Tateishi
authors.affiliation: Department of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kishino
authors.affiliation: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Miyazaki
authors.affiliation: Department of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Ukihide
authors.initials: U
authors.lastname: Tateishi
authors.affiliation: Department of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan.
authors.forename: Tamiko
authors.initials: T
authors.lastname: Takemura
authors.affiliation: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Naohiko
authors.initials: N
authors.lastname: Inase
mesh_terms: D000328:Adult; D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D001706:Biopsy / Q000379:methods; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D007564:Japan; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012129:Respiratory Function Tests / Q000379:methods; D012189:Retrospective Studies; D013223:Statistics as Topic; D000067251:Symptom Flare Up; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: fibroblastic foci; hypersensitivity pneumonia; interstitial lung disease; lung biopsy