title: Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer.
abstract: In this study, we evaluated mRNA expression levels of interleukin (IL)-10/IL-17A by quantitative real-time PCR and their clinical importance in cervical cancer. The IL-10 mRNA levels were higher in cervical cancer tissues as compared with corresponding normal tissues (p < 0.05). Moreover, IL-17A mRNA was significantly increased in cervical cancer tissues than in normal tissues (p < 0.05). Moreover, the high expression level of IL-10 mRNA was markedly related to International League of Gynecology and Obstetrics (FIGO) stage (p = 0.001), but no significant association was found with other clinical factors including age, tumor size, histological grades, and lymph node metastasis. Moreover, high expression levels of IL-17A were not associated with patients' age, tumor size, FIGO stage, and histological grades while IL-17A expression was strongly linked to lymphatic metastasis (p = 0.001). These findings showed that IL-17A might have a crucial role in cervical cancer metastasis. Taken together, IL-17A expression was strongly linked to lymphatic metastasis, indicating that IL-17A might have a crucial role in cervical cancer metastasis. Moreover, our study suggested the association of IL-10 mRNA expression with clinical stage.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Imam Khomeini Hospital Complex and Vali Asr Hospital, Oncology Ward, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Setareh
authors.initials: S
authors.lastname: Akhavan
authors.affiliation: Department of Gynecology, Imam Reza Hospital, AJA University of Medical Sciences, Tehran, Iran.
authors.forename: Aghdas
authors.initials: A
authors.lastname: Safari
authors.affiliation: Department of Gynecology, Hajar Hospital, AJA University of Medical Sciences, Tehran, Iran.
authors.forename: Sima
authors.initials: S
authors.lastname: Azizmohammadi
authors.affiliation: Department of Gynecology, Hajar Hospital, AJA University of Medical Sciences, Tehran, Iran.
authors.forename: Susan
authors.initials: S
authors.lastname: Azizmohammadi
authors.affiliation: Department of Biology, California State University Stanislaus, California, USA.
authors.forename: Maysam
authors.initials: M
authors.lastname: Aslami
authors.affiliation: Department of Molecular Biology, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Emad
authors.initials: E
authors.lastname: Yahaghi
authors.affiliation: Department of Gynecology, Khanevadeh Hospital, AJA University of Medical Sciences, Tehran, Iran. mehri_seifoleslami@yahoo.com.sg.
authors.forename: Mehri
authors.initials: M
authors.lastname: Seifoleslami
keywords: Cervical; Grade; Histological; IL-17A and IL-10; Metastasis
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