title: Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents.
abstract: OBJECTIVE
  Childhood-onset obesity is associated with increased mortality and morbidity related to cardiovascular diseases (CVD) during adulthood. Dyslipidemia has a fundamental role in the pathogenesis of CVD. This study aimed to evaluate the prevalence of dyslipidemia and related factors among obese children and adolescents.
  
  
  METHODS
  Obese patients aged between 2 and 18 years were included in the study. Serum concentrations of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), fasting glucose levels, insulin, thyroid-stimulating hormone (TSH), free thyroxine (fT4), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and liver ultrasound findings were evaluated retrospectively.
  
  
  RESULTS
  Among 823 obese patients, 353 (42.9%) met the dyslipidemia criteria: 21.7% had hypertriglyceridemia, 19.7% had low levels of HDL-C, 18.6% had hypercholesterolemia, and 13.7% had high levels of LDL-C. Older age and/or high body mass index (BMI) were related to increased prevalence of dyslipidemia. Hepatosteatosis was more common among dyslipidemic patients. The frequency of insulin resistance (IR) and of higher levels of ALT and TSH were also detected in dyslipidemic patients. Patients with both dyslipidemia and grade 2-3 hepatosteatosis had higher levels of ALT, AST and TSH and lower levels of fT4.
  
  
  CONCLUSIONS
  Prevalence of dyslipidemia is high in obese children, and hypertriglyceridemia is in the foreground. Higher levels of IR and more apparent abnormal liver function test results are observed in the context of dyslipidemia and hepatosteatosis coexistence. Metabolic and hormonal alterations related with thyroid functions may also be associated with dyslipidemia and hepatosteatosis in obese patients.
authors.affiliation: Ankara Children's Hematology and Oncology Training and Research Hospital, Clinic of Pediatric Endocrinology, Ankara, Turkey Phone: +90 0532 580 88 62 E-mail: ekerbicerselin@yahoo.com.
authors.forename: Selin
authors.initials: S
authors.lastname: Elmaoğulları
authors.forename: Derya
authors.initials: D
authors.lastname: Tepe
authors.forename: Seyit Ahmet
authors.initials: SA
authors.lastname: Uçaktürk
authors.forename: Fatma
authors.initials: F
authors.lastname: Karaca Kara
authors.forename: Fatma
authors.initials: F
authors.lastname: Demirel
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D016009:Chi-Square Distribution; D002648:Child; D015897:Comorbidity; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology; D005234:Fatty Liver / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D063766:Pediatric Obesity / Q000097:blood* / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014421:Turkey / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013972:Thyrotropin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013974:Thyroxine
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