title: Comparison of the protective effects of intratympanic dexamethasone and methylprednisolone against cisplatin-induced ototoxicity.
abstract: OBJECTIVE
  This study aimed to compare the efficacies of intratympanic dexamethasone and methylprednisolone in preventing in cisplatin-induced ototoxicity in rats.
  
  
  METHODS
  Experimental groups of rats (n = 8 each) received intratympanic isotonic saline, intraperitoneal cisplatin and intratympanic isotonic saline, intraperitoneal cisplatin and intratympanic dexamethasone, or intraperitoneal cisplatin and intratympanic methylprednisolone. Distortion product otoacoustic emission thresholds were compared on days 0 and 10 in all rats, and correlations between drug effects and changes in cochlear histology were evaluated.
  
  
  RESULTS
  Distortion product otoacoustic emission thresholds were comparable in groups III and IV (p > 0.05). Significant protection against cisplatin-induced ototoxicity was seen in groups III and IV compared with group II (p < 0.05). Dexamethasone and, to a lesser extent, methylprednisolone protected against cellular apoptosis in cisplatin-induced ototoxicity.
  
  
  CONCLUSIONS
  Dexamethasone (and possibly methylprednisolone) may be clinically useful as an intratympanic chemopreventive agent to treat cisplatin ototoxicity. Future clinical studies should investigate the use of dexamethasone for this purpose in adult patients.
authors.affiliation: Department of Otolaryngology,Kocaeli Derince Research and Training Hospital,Kocaeli,Turkey.
authors.forename: H E
authors.initials: HE
authors.lastname: Özel
authors.affiliation: Department of Otolaryngology,Kocaeli Derince Research and Training Hospital,Kocaeli,Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Özdoğan
authors.affiliation: Department of Histology and Embryology,Celal Bayar University School of Vocational Health Service,Manisa,Turkey.
authors.forename: S G
authors.initials: SG
authors.lastname: Gürgen
authors.affiliation: Department of Otolaryngology,Kocaeli Derince Research and Training Hospital,Kocaeli,Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Esen
authors.affiliation: Department of Otolaryngology,Kocaeli Derince Research and Training Hospital,Kocaeli,Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Genç
authors.affiliation: Department of Otolaryngology,Kocaeli Derince Research and Training Hospital,Kocaeli,Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Selçuk
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D011897:Random Allocation; D017208:Rats, Wistar
chemical_list: D000970:Antineoplastic Agents; D018696:Neuroprotective Agents; D003907:Dexamethasone; D002945:Cisplatin; D008775:Methylprednisolone
keywords: Animal; Chemically-Induced Disorders; Cisplatin; Dexamethasone; Hearing Loss; Methylprednisolone; Model; Sensorineural