title: Urinary angiotensinogen excretion is associated with blood pressure in obese young adults.
abstract: Intrarenal RAS has been suggested to be involved in the pathogenesis of hypertension. It was recently reported that urinary angiotensinogen excretion levels are associated with intrarenal RAS. However, few markers predicting intrarenal RAS have been investigated in obese young subjects. The present study evaluated the association between blood pressure and intrarenal RAS activity, inflammation and oxidative stress in obese young adults. Urinary angiotensinogen excretion and urinary monocyte chemotactic protein (MCP)-1, and urinary thiobarbituric acid reaction substance (TBARS) as markers of intrarenal RAS activity, inflammation, and oxidative stress, respectively, were determined from morning urine of 111 young male adults. Participants were divided into two groups based on the body mass index (BMI). Natural log-transformed urinary angiotensinogen excretion level was significantly associated with blood pressure, MCP-1 excretion, and TBARS excretion elevation in the obese group (BMI ≥25 kg/m(2)). Multivariable analyses showed that every 1 standard deviation increase in natural-log transformed urinary angiotensinogen and MCP-1 excretion, but not TBARS excretion level was associated with elevated blood pressure in the obese group. These results indicate that urinary angiotensinogen and MCP-1 excretion were associated with blood pressure elevation in this population of obese young adults. It suggested that inappropriate RAS activity and inflammation precedes hypertension in obese young subjects and urinary angiotensinogen could be a screening maker for hypertension in young obese subjects.
authors.affiliation: a Division of Nephrology , Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan .|b Department of Clinical Pharmacology and Therapeutics , Tohoku University Graduate School of Pharmaceutical Sciences , Sendai , Japan .
authors.forename: Emiko
authors.initials: E
authors.lastname: Sato
authors.affiliation: a Division of Nephrology , Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan .|c Health Administration Center, Tohoku University , Sendai , Japan .|d Division of Integrative Renal Replacement Therapy , Tohoku University Graduate School of Medicine , Sendai , Japan , and.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Mori
authors.affiliation: e Department of Pharmacy , Tohoku University Hospital , Sendai , Japan.
authors.forename: Michihiro
authors.initials: M
authors.lastname: Satoh
authors.affiliation: a Division of Nephrology , Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan .
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Fujiwara
authors.affiliation: a Division of Nephrology , Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan .
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Nakamichi
authors.affiliation: a Division of Nephrology , Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan .
authors.forename: Ikuko
authors.initials: I
authors.lastname: Oba
authors.affiliation: a Division of Nephrology , Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan .|c Health Administration Center, Tohoku University , Sendai , Japan .
authors.forename: Susumu
authors.initials: S
authors.lastname: Ogawa
authors.affiliation: c Health Administration Center, Tohoku University , Sendai , Japan .
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kinouchi
authors.affiliation: a Division of Nephrology , Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan .|b Department of Clinical Pharmacology and Therapeutics , Tohoku University Graduate School of Pharmaceutical Sciences , Sendai , Japan .
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.affiliation: a Division of Nephrology , Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan .|d Division of Integrative Renal Replacement Therapy , Tohoku University Graduate School of Medicine , Sendai , Japan , and.
authors.forename: Sadayoshi
authors.initials: S
authors.lastname: Ito
authors.affiliation: c Health Administration Center, Tohoku University , Sendai , Japan .
authors.forename: Wataru
authors.initials: W
authors.lastname: Hida
mesh_terms: D000293:Adolescent; D000808:Angiotensinogen / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D018932:Chemokine CCL2 / Q000652:urine*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000652:urine*; D007249:Inflammation; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000503:physiopathology / Q000652:urine*; D050177:Overweight / Q000503:physiopathology / Q000652:urine; D018384:Oxidative Stress; D012084:Renin-Angiotensin System / Q000502:physiology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D017392:Thiobarbituric Acid Reactive Substances; D000808:Angiotensinogen
keywords: Angiotensinogen; blood pressure; intrarenal renin-angiotensin system; obese young adults; urinary biomarker