title: Different behaviour of BK-virus infection in liver transplant recipients.
abstract: Polyomavirus BK (BKV) infects up to 90% of the general population. After primary infection, occurring early during childhood, a state of non-replicative infection is established in the reno-urinary tract, without complications for immunocompetent hosts. In immunocompromised individuals, particularly transplanted patients, asymptomatic BKV viremia and/or viruria can be observed. Renal grafts may also be sources of infection as BKV prefers kidneys rather than other solid organs for transplantation such as the liver. The mechanism behind the higher incidence of BKV infection in kidney transplant patients, compared to liver or heart transplantation, is unclear and the prevalence of BKV infection in non-renal solid organ transplants has not been yet thoroughly investigated. We evaluated the prevalence of Polyomavirus BK infection among liver transplant recipients. A PubMed search was conducted using the terms BKV infection AND liver transplant recipients; BKV AND non-renal solid organ transplant*; BKV infection AND immunosuppression; the search was limited to title/abstract and English-language articles published from 2000, to March 2015. Eleven relevant studies suggest that the prevalence of BKV viruria and/or viremia among liver transplant recipients is less than that reported in kidney or heart transplant recipients, except when chronic kidney disease (CKD) is present at the same time. Data also suggest that viruric and viremic patients have higher levels of serum creatinine than BKV negative patients. Moreover, no specific immunosuppressive drugs are associated with the onset of BKV nephropathy. The comorbidity of transplantation and CKD could play a major role in promoting BKV replication.
authors.affiliation: Ilaria Umbro, Francesca Tinti, Paolo Muiesan, The Liver Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2GW, United Kingdom.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Umbro
authors.affiliation: Ilaria Umbro, Francesca Tinti, Paolo Muiesan, The Liver Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2GW, United Kingdom.
authors.forename: Francesca
authors.initials: F
authors.lastname: Tinti
authors.affiliation: Ilaria Umbro, Francesca Tinti, Paolo Muiesan, The Liver Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2GW, United Kingdom.
authors.forename: Paolo
authors.initials: P
authors.lastname: Muiesan
authors.affiliation: Ilaria Umbro, Francesca Tinti, Paolo Muiesan, The Liver Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2GW, United Kingdom.
authors.forename: Anna Paola
authors.initials: AP
authors.lastname: Mitterhofer
mesh_terms: D001739:BK Virus / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D015897:Comorbidity; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016031:Liver Transplantation / Q000009:adverse effects*; D009894:Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D027601:Polyomavirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D012307:Risk Factors; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D014775:Virus Activation; D014779:Virus Replication
chemical_list: D007166:Immunosuppressive Agents
keywords: BK virus; Liver transplant recipients; Liver transplantation; Polyomavirus BK infection
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