title: New Methods for the Analysis of Fat-Soluble Vitamins in Infant Formula and Adult Nutritionals.
abstract: The AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN) defined fat-soluble vitamins (FSVs) to include vitamins A, D, E, and K. The levels of FSVs have been closely scrutinized because of a number of factors, including nutrition value especially in foods used to provide sole-source nutrition and the potential for health risks associated with content both below and above recommended levels. Stricter scrutiny and emphasis on nutrient-level compliance with regulatory requirements placed an increased demand on analytical methods that were fit-for-purpose, provided accurate and precise results. Over time, compendial methods have been developed and published by organizations such as AOAC INTERNATIONAL, the European Committee for Standardization, the International Dairy Federation, and the International Organization for Standardization, among others. In general, these methods have shown adequate precision for regulatory compliance based on example food matrixes for which they were designed. However, method evaluation for infant formulas and adult nutritional products was limited to very few matrixes within these categories. As such, method applicability gaps were noted and correlated with more complicated or diverse product matrixes. AOAC undertook the task of modernizing test methods for the determination of nutrients in infant formulas and in adult nutritional products formulated specifically for both healthy adults and those requiring specific nutritional intake. Composition of products in this category continued to evolve, which in turn presented increasing and new challenges to analytical methodology. A summary of a new generation of candidate compendial methods for determination of FSVs in these matrixes, identified by SPIFAN, is presented here.
authors.affiliation: Abbott Nutrition, 3300 Stelzer Rd, Building RP4-2, Columbus, OH 43219-3034, USA.
authors.forename: Don
authors.initials: D
authors.lastname: Gilliland
mesh_terms: D000328:Adult; D005223:Fats / Q000737:chemistry*; D005504:Food Analysis / Q000379:methods*; D005526:Food, Formulated / Q000032:analysis*; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry*; D009753:Nutritive Value; D012995:Solubility; D014815:Vitamins / Q000032:analysis* / Q000737:chemistry*
chemical_list: D005223:Fats; D014815:Vitamins