title: Pancreatic Neuroendocrine Neoplasms.
abstract: Pancreatic neuroendocrine neoplasms (Pan-NENs) are rare but clinically important lesions. Pan-NENs are known for and often categorized by their capacity to produce clinical syndromes mediated by the production of hormones. Despite sometimes presenting dramatically from excessive hormone production, not all Pan-NENs produce functional hormone, and they can pose diagnostic challenges to practicing pathologists. Distinguishing Pan-NENs from mimics can be crucial, because Pan-NENs carry different prognoses and have unique treatments available due to their specific biological properties. This article reviews the current categorization and features of Pan-NENs.
authors.affiliation: Department of Surgical Pathology, University of Wisconsin Hospital and Clinics, Room A4/204-3224, 600 Highland Ave., Madison, WI 53792-3224, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Rosenbaum
authors.affiliation: Department of Surgical Pathology, University of Wisconsin Hospital and Clinics, Room A4/204-3224, 600 Highland Ave., Madison, WI 53792-3224, USA. Electronic address: rvlloyd@wisc.edu.
authors.forename: Ricardo Vincent
authors.initials: RV
authors.lastname: Lloyd
keywords: Cancer; Gastrinoma; Glucagonoma; Insulinoma; Ki-67; Neuroendocrine; Pan-NEN; Pancreas