title: Combinatorial synthesis of deuterium-enriched atorvastatin.
abstract: It becomes more and more difficult to discover a new drug by existing models. The concept of deuteration has gained attention due to its advantages in the study of clinical pharmacokinetics and metabolic profiles. Herein we built a library of deuterated atorvastatins using combinatorial chemistry, and all 16 D-compounds were characterized by 1H NMR, 13C NMR, MS, and elemental analysis.
authors.affiliation: School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.|Marine Biomedical Research Institute, Qingdao, 266071, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.|Marine Biomedical Research Institute, Qingdao, 266071, China.
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, University of Nevada, Reno, Reno, 89557-0216, USA. aczarnik@unr.edu.
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Czarnik
authors.affiliation: School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. wbli92128@ouc.edu.cn.|Marine Biomedical Research Institute, Qingdao, 266071, China. wbli92128@ouc.edu.cn.
authors.forename: Wenbao
authors.initials: W
authors.lastname: Li
mesh_terms: D000069059:Atorvastatin / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D020650:Combinatorial Chemistry Techniques; D003903:Deuterium / Q000737:chemistry*
chemical_list: D000069059:Atorvastatin; D003903:Deuterium
keywords: Atorvastatin; Combinatorial chemistry; Deuterated derivatives; Deuterium
references.citation: Arch Biochem Biophys. 2007 Sep 1;465(1):82-9
references.pmid: 17562323
references.citation: J Med Chem. 2014 May 8;57(9):3595-611
references.pmid: 24294889
references.citation: Science. 1974 Feb 1;183(4123):427-8
references.pmid: 4203023