title: Forensic and population genetic analysis of Xinjiang Uyghur population on 21 short tandem repeat loci of 6-dye GlobalFiler™ PCR Amplification kit.
abstract: Estimating the allele frequencies and forensic statistical parameters of commonly used short tandem repeat (STR) loci of the Uyghur population, which is the fifth largest group in China, provides a more precise reference database for forensic investigation. The 6-dye GlobalFiler™ Express PCR Amplification kit incorporates 21 autosomal STRs, which have been proven that could provide reliable DNA typing results and enhance the power of discrimination. Here we analyzed the GlobalFiler STR loci on 1962 unrelated individuals from Chinese Uyghur population of Xinjiang, China. No significant deviations from Hardy-Weinberg equilibrium and linkage disequilibrium were detected within and between the GlobalFiler STR loci. SE33 showed the greatest power of discrimination in Uyghur population, whereas TPOX showed the lowest. The combined power of discrimination was 99.999999999999999999999998746%. No significant difference was observed between Uyghur and the other two Uyghur populations at all tested STRs, as well as Dai and Mongolian. Significant differences were only observed between Uyghur and other Chinese populations at TH01, as well as Central-South Asian at D13S317, East Asian at TH01 and VWA. The phylogenetic analysis showed that Uyghur is genetically close to Chinese populations, as well as East Asian and Central-South Asian.
authors.affiliation: Criminal Science & Technology Institute, Bureau of Public Security, Urumqi, China.
authors.forename: Honghua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Mingying
authors.initials: M
authors.lastname: Xia
authors.affiliation: Criminal Science & Technology Institute, Bureau of Public Security, Urumqi, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Qi
authors.affiliation: Criminal Science & Technology Institute, Bureau of Public Security, Urumqi, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.affiliation: Criminal Science & Technology Institute, Bureau of Public Security, Urumqi, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Song
authors.affiliation: Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.affiliation: Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Yang
authors.affiliation: Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.affiliation: Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China. Electronic address: lee6013282@gmail.com.
authors.forename: Liming
authors.initials: L
authors.lastname: Li
authors.affiliation: Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China. Electronic address: lishilin@fudan.edu.cn.
authors.forename: Shilin
authors.initials: S
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D016172:DNA Fingerprinting; D005006:Ethnicity / Q000235:genetics*; D053803:Forensic Genetics / Q000379:methods; D005787:Gene Frequency; D005828:Genetics, Population / Q000379:methods; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction / Q000295:instrumentation / Q000379:methods*; D011110:Polymorphism, Genetic
keywords: GlobalFiler; Short tandem repeat; Uyghur; Xinjiang