title: miR-17-92 host gene, uderexpressed in gastric cancer and its expression was negatively correlated with the metastasis.
abstract: BACKGROUND
  This study aimed to evaluate the expression of miR-17-92 host gene (MIR17HG), in gastric cancer and paired normal adjacent tissues for the 1st time.
  
  
  METHODS
  Using quantitative real-time-polymerase chain reaction, the MIR17HG expression was assessed in 30 paired tumoral and nontumoral gastric tissue samples.
  
  
  RESULTS
  Our results showed that this transcript was significantly underexpressed in gastric tumors compared with normal ones. Furthermore, there was an association between the expression levels of MIR17HG and gastric cancer grades and stages. Moreover, the expression level of MIR17HG was conversely associated with the size of tumoral specimens in early stages (stages I and II). We also observed an association between the presence of metastasis and lower expression of MIR17HG.
  
  
  CONCLUSIONS
  Our results suggest that MIR17HG gene expression is dysregulated in gastric cancer in which it may indicate a tumor suppressive function of this miRNA cluster host gene in gastric cancer.
authors.forename: F
authors.initials: F
authors.lastname: Bahari
authors.forename: M
authors.initials: M
authors.lastname: Emadi-Baygi
authors.affiliation: Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences; Applied Physiology Research Center, Isfahan University of Medical Sciences; Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: P
authors.initials: P
authors.lastname: Nikpour
mesh_terms: D000368:Aged; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009362:Neoplasm Metastasis / Q000235:genetics* / Q000473:pathology; D062085:RNA, Long Noncoding; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: C568997:MIR17HG, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding