title: CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children's Oncology Group Genome-Wide Association Study.
abstract: OBJECTIVE
  Interindividual variability in the dose-dependent association between anthracyclines and cardiomyopathy suggests that genetic susceptibility could play a role. The current study uses an agnostic approach to identify genetic variants that could modify cardiomyopathy risk.
  
  
  METHODS
  A genome-wide association study was conducted in childhood cancer survivors with and without cardiomyopathy (cases and controls, respectively). Single-nucleotide polymorphisms (SNPs) that surpassed a prespecified threshold for statistical significance were independently replicated. The possible mechanistic significance of validated SNP(s) was sought by using healthy heart samples.
  
  
  RESULTS
  No SNP was marginally associated with cardiomyopathy. However, SNP rs1786814 on the CELF4 gene passed the significance cutoff for gene-environment interaction (Pge = 1.14 × 10(-5)). Multivariable analyses adjusted for age at cancer diagnosis, sex, anthracycline dose, and chest radiation revealed that, among patients with the A allele, cardiomyopathy was infrequent and not dose related. However, among those exposed to greater than 300 mg/m(2) of anthracyclines, the rs1786814 GG genotype conferred a 10.2-fold (95% CI, 3.8- to 27.3-fold; P < .001) increased risk of cardiomyopathy compared with those who had GA/AA genotypes and anthracycline exposure of 300 mg/m(2) or less. This gene-environment interaction was successfully replicated in an independent set of anthracycline-related cardiomyopathy. CUG-BP and ETR-3-like factor proteins control developmentally regulated splicing of TNNT2, the gene that encodes for cardiac troponin T (cTnT), a biomarker of myocardial injury. Coexistence of more than one cTnT variant results in a temporally split myofilament response to calcium, which causes decreased contractility. Analysis of TNNT2 splicing variants in healthy human hearts suggested an association between the rs1786814 GG genotype and coexistence of more than one TNNT2 splicing variant (90.5% GG v 41.7% GA/AA; P = .005).
  
  
  CONCLUSIONS
  We report a modifying effect of a polymorphism of CELF4 (rs1786814) on the dose-dependent association between anthracyclines and cardiomyopathy, which possibly occurs through a pathway that involves the expression of abnormally spliced TNNT2 variants.
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Xuexia
authors.initials: X
authors.lastname: Wang
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Can-Lan
authors.initials: CL
authors.lastname: Sun
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Quiñones-Lombraña
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Purnima
authors.initials: P
authors.lastname: Singh
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Wendy
authors.initials: W
authors.lastname: Landier
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Hageman
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Molly
authors.initials: M
authors.lastname: Mather
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Kent D
authors.initials: KD
authors.lastname: Taylor
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Yii-Der Ida
authors.initials: YD
authors.lastname: Chen
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Saro H
authors.initials: SH
authors.lastname: Armenian
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Naomi
authors.initials: N
authors.lastname: Winick
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Jill P
authors.initials: JP
authors.lastname: Ginsberg
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Neglia
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Oeffinger
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Castellino
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Zoann E
authors.initials: ZE
authors.lastname: Dreyer
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Robison
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN.
authors.forename: Javier G
authors.initials: JG
authors.lastname: Blanco
authors.affiliation: Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Can-Lan Sun, Molly Mather, Saro H. Armenian, City of Hope, Duarte; Jerome I. Rotter, Kent D. Taylor, Yii-Der Ida Chen, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Torrance, CA; Adolfo Quiñones-Lombraña, Javier G. Blanco, State University of New York at Buffalo, Buffalo; Kevin C. Oeffinger, Memorial Sloan Kettering Cancer Center, New York, NY; Purnima Singh, Wendy Landier, Lindsey Hageman, Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Texas Children's Cancer Center, Houston, TX; Jill P. Ginsberg, Childrens Hospital of Philadelphia, Philadelphia, PA; Joseph P. Neglia, University of Minnesota, Minneapolis, MN; Sharon M. Castellino, Emory University and Children's Healthcare of Atlanta, Atlanta, GA; and Melissa M. Hudson, Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN. sbhatia@peds.uab.edu.
authors.forename: Smita
authors.initials: S
authors.lastname: Bhatia
mesh_terms: D000293:Adolescent; D000328:Adult; D018943:Anthracyclines / Q000009:adverse effects*; D000067878:CELF Proteins / Q000235:genetics*; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D020641:Polymorphism, Single Nucleotide; D020033:Protein Isoforms; D020107:Troponin T / Q000096:biosynthesis / Q000235:genetics; D055815:Young Adult
chemical_list: D018943:Anthracyclines; D000067878:CELF Proteins; C422243:CELF4 protein, human; D020033:Protein Isoforms; C545568:TNNT2 protein, human; D020107:Troponin T
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