title: Serotonin Transporter Gene (SLC6A4) Methylation Associates With Neonatal Intensive Care Unit Stay and 3-Month-Old Temperament in Preterm Infants.
abstract: Preterm birth and Neonatal Intensive Care Unit (NICU) stay are early adverse stressful experiences, which may result in an altered temperamental profile. The serotonin transporter gene (SLC6A4), which has been linked to infant temperament, is susceptible to epigenetic regulation associated with early stressful experience. This study examined a moderation model in which the exposure to NICU-related stress and SLC6A4 methylation moderated infant temperament at 3 months of age. SLC6A4 methylation at 20 CpG sites was quantified in preterm infants (N = 48) and full-term infants (N = 30) from Italian middle-class families. Results suggested that in preterm infants NICU-related stress might be associated with alterations of serotonergic tone as a consequence of SLC6A4 methylation, which in turn, might associate with temperamental difficulties assessed at 3 months of age.
authors.affiliation: IRCCS Eugenio Medea.
authors.forename: Rosario
authors.initials: R
authors.lastname: Montirosso
authors.affiliation: IRCCS Eugenio Medea.
authors.forename: Livio
authors.initials: L
authors.lastname: Provenzi
authors.affiliation: University of Milan.
authors.forename: Monica
authors.initials: M
authors.lastname: Fumagalli
authors.affiliation: University of Milan.
authors.forename: Ida
authors.initials: I
authors.lastname: Sirgiovanni
authors.affiliation: IRCCS Eugenio Medea.
authors.forename: Roberto
authors.initials: R
authors.lastname: Giorda
authors.affiliation: IRCCS Eugenio Medea.
authors.forename: Uberto
authors.initials: U
authors.lastname: Pozzoli
authors.affiliation: IRCCS Eugenio Medea.
authors.forename: Silvana
authors.initials: S
authors.lastname: Beri
authors.affiliation: IRCCS Eugenio Medea.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Menozzi
authors.affiliation: University of Massachusetts and Division of Newborn Medicine.
authors.forename: Ed
authors.initials: E
authors.lastname: Tronick
authors.affiliation: Sacra Famiglia Hospital.
authors.forename: Francesco
authors.initials: F
authors.lastname: Morandi
authors.affiliation: University of Milan.
authors.forename: Fabio
authors.initials: F
authors.lastname: Mosca
authors.affiliation: IRCCS Eugenio Medea.
authors.forename: Renato
authors.initials: R
authors.lastname: Borgatti
mesh_terms: D019175:DNA Methylation / Q000235:genetics / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007363:Intensive Care Units, Neonatal; D008297:Male; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism*; D013694:Temperament / Q000502:physiology*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins