title: New building blocks or dendritic pseudopeptides for metal chelating.
abstract: Dendritic oligopeptides have been reported as useful building blocks for many interactions. Starting from hydrazine, we described an approach to create new dendritic pseudopeptides linked with biological systems, such as cell membrane, as chelate metal, Ni(2+)-nitrilotriacetic acid moieties which could target histidine rich peptides or proteins. Depending on the nature of these new chemical recognition units, they could be integrated into a peptide by coupling in C or N-termini.Graphical abstract:Dendrimer formation.
authors.affiliation: UMR CNRS 6226, Institut des Sciences Chimiques de Rennes (ISCR), 263 Avenue du Général Leclerc, 35042 Rennes Cedex, France.
authors.forename: Min
authors.initials: M
authors.lastname: Ruan
authors.affiliation: UMR CNRS 6226, Institut des Sciences Chimiques de Rennes (ISCR), 263 Avenue du Général Leclerc, 35042 Rennes Cedex, France.
authors.forename: Irène
authors.initials: I
authors.lastname: Nicolas
authors.affiliation: UMR CNRS 6226, Institut des Sciences Chimiques de Rennes (ISCR), 263 Avenue du Général Leclerc, 35042 Rennes Cedex, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Baudy-Floc'h
keywords: Aza-NTA; Aza-β3-amino acids; Aza-β3-peptides; Dendritic pseudopeptides
references.citation: J Chromatogr. 1987 Dec 18;411:177-84
references.pmid: 3443622
references.citation: Curr Pharm Des. 2010;16(28):3185-203
references.pmid: 20687878
references.citation: Mol Immunol. 2007 Apr;44(11):3024-36
references.pmid: 17292472
references.citation: Biophys J. 2000 Jun;78(6):3275-85
references.pmid: 10828003
references.citation: J Am Chem Soc. 2004 Mar 24;126(11):3392-3
references.pmid: 15025444
references.citation: J Chromatogr A. 2003 Feb 21;988(1):1-23
references.pmid: 12647817
references.citation: J Org Chem. 2005 Dec 23;70(26):10701-8
references.pmid: 16355988
references.citation: J Med Chem. 2012 Dec 27;55(24):10885-95
references.pmid: 23148564
references.citation: Anal Chem. 1997 Jun 1;69(11):1979-85
references.pmid: 9183172
references.citation: J Am Chem Soc. 2005 Jul 27;127(29):10205-15
references.pmid: 16028931
references.citation: Anal Chem. 1996 Feb 1;68(3):490-7
references.pmid: 8712358
references.citation: J Immunol Methods. 1995 Jun 14;183(1):65-76
references.pmid: 7602140
references.citation: Electrophoresis. 2003 Feb;24(4):599-610
references.pmid: 12601727