title: Determination of the purity of valine by isocratic liquid chromatography coupled with charged aerosol detection (CAD).
abstract: A liquid chromatography coupled with charged aerosol detection (LC-CAD) procedure; capable of separating and quantifying the most common impurities of valine at levels as low as 0.05 per cent (m/m), has been developed. The procedure is simple (isocratic), rapid, linear, sensitive and repeatable. It employs a widely available and inexpensive stationary phase (C18).
authors.affiliation: European Directorate for the Quality of Medicines & HealthCare (EDQM), Council of Europe, Strasbourg, France, andrea.lodi@edqm.eu.
authors.forename: A
authors.initials: A
authors.lastname: Lodi
authors.affiliation: University of Strathclyde, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Angus
authors.affiliation: European Directorate for the Quality of Medicines & HealthCare (EDQM), Council of Europe, Strasbourg, France.
authors.forename: C J
authors.initials: CJ
authors.lastname: Nap
authors.affiliation: University of Strathclyde, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Skellern
authors.affiliation: University of Lorraine, France.
authors.forename: A
authors.initials: A
authors.lastname: Nicolas
mesh_terms: D000336:Aerosols / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods; D004340:Drug Contamination; D014633:Valine / Q000032:analysis* / Q000592:standards
chemical_list: D000336:Aerosols; D014633:Valine
keywords: CAD; LC; amino acids; impurities; valine