title: Weight loss predictability by plasma metabolic signatures in adults with obesity and morbid obesity of the DiOGenes study.
abstract: OBJECTIVE
  Aim is to predict successful weight loss by metabolic signatures at baseline and to identify which differences in metabolic status may underlie variations in weight loss success.
  
  
  METHODS
  In DiOGenes, a randomized, controlled trial, weight loss was induced using a low-calorie diet (800 kcal) for 8 weeks. Men (N = 236) and women (N = 431) as well as groups with overweight/obesity and morbid obesity were studied separately. The relation between the metabolic status before weight loss and weight loss was assessed by stepwise regression on multiple data sets, including anthropometric parameters, NMR-based plasma metabolites, and LC-MS-based plasma lipid species.
  
  
  RESULTS
  Maximally, 57% of the variation in weight loss success can be predicted by baseline parameters. The most powerful predictive models were obtained in subjects with morbid obesity. In these models, the metabolites most predictive for weight loss were acetoacetate, triacylglycerols, phosphatidylcholines, specific amino acids, and creatine and creatinine. This metabolic profile suggests that high energy metabolism activity results in higher amounts of weight loss.
  
  
  CONCLUSIONS
  Possible predictive (pre-diet) markers were found for amount of weight loss for specific subgroups.
authors.affiliation: Department of Microbiology and Systems Biology, TNO, Zeist, The Netherlands.|Netherlands Metabolomics Centre, Leiden, The Netherlands.
authors.forename: Johanna H M
authors.initials: JH
authors.lastname: Stroeve
authors.affiliation: Netherlands Metabolomics Centre, Leiden, The Netherlands.|Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.|Laboratory of Systems and Synthetic Biology, Wageningen University, Wageningen, The Netherlands.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Saccenti
authors.affiliation: Department of Microbiology and Systems Biology, TNO, Zeist, The Netherlands.|Netherlands Metabolomics Centre, Leiden, The Netherlands.
authors.forename: Jildau
authors.initials: J
authors.lastname: Bouwman
authors.affiliation: Netherlands Metabolomics Centre, Leiden, The Netherlands.|Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.
authors.forename: Adrie
authors.initials: A
authors.lastname: Dane
authors.affiliation: Netherlands Metabolomics Centre, Leiden, The Netherlands.|Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.
authors.forename: Katrin
authors.initials: K
authors.lastname: Strassburg
authors.affiliation: Netherlands Metabolomics Centre, Leiden, The Netherlands.|Laboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands.
authors.forename: Jacques
authors.initials: J
authors.lastname: Vervoort
authors.affiliation: Netherlands Metabolomics Centre, Leiden, The Netherlands.|Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hankemeier
authors.affiliation: Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
authors.forename: Arne
authors.initials: A
authors.lastname: Astrup
authors.affiliation: Netherlands Metabolomics Centre, Leiden, The Netherlands.|Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Age K
authors.initials: AK
authors.lastname: Smilde
authors.affiliation: Department of Microbiology and Systems Biology, TNO, Zeist, The Netherlands.|Netherlands Metabolomics Centre, Leiden, The Netherlands.
authors.forename: Ben
authors.initials: B
authors.lastname: van Ommen
authors.affiliation: Netherlands Metabolomics Centre, Leiden, The Netherlands.|DSM Food Specialties Delft, Delft, The Netherlands.|Department of Human Biology, Maastricht University, Maastricht, the Netherlands.
authors.forename: Wim H M
authors.initials: WH
authors.lastname: Saris
mesh_terms: D000328:Adult; D015992:Body Mass Index; D031204:Caloric Restriction; D002784:Cholesterol / Q000097:blood; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D055432:Metabolomics / Q000379:methods; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D009767:Obesity, Morbid / Q000188:drug therapy* / Q000378:metabolism*; D010949:Plasma / Q000737:chemistry*; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss / Q000502:physiology*
chemical_list: D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol