title: Recent Advance in Liquid Chromatography/Mass Spectrometry Techniques for Environmental Analysis in Japan.
abstract: The techniques and measurement methods developed in the Environmental Survey and Monitoring of Chemicals by Japan's Ministry of the Environment, as well as a large amount of knowledge archived in the survey, have led to the advancement of environmental analysis. Recently, technologies such as non-target liquid chromatography/high resolution mass spectrometry and liquid chromatography with micro bore column have further developed the field. Here, the general strategy of a method developed for the liquid chromatography/mass spectrometry (LC/MS) analysis of environmental chemicals with a brief description is presented. Also, a non-target analysis for the identification of environmental pollutants using a provisional fragment database and "MsMsFilter," an elemental composition elucidation tool, is presented. This analytical method is shown to be highly effective in the identification of a model chemical, the pesticide Bendiocarb. Our improved micro-liquid chromatography injection system showed substantially enhanced sensitivity to perfluoroalkyl substances, with peak areas 32-71 times larger than those observed in conventional LC/MS.
authors.affiliation: Graduate School of Bioscience and Biotechnology, Chubu University.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Suzuki
keywords: LC/MS; accurate mass; atmospheric pressure ionization; environmental analysis; non-target analysis
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