title: The role of IL-11 in immunity and cancer.
abstract: Interleukin-11 (IL-11) is a member of the glycoprotein-130 (GP-130) cytokines that utilizes the GP-130 signaling pathway shared by other cytokines of the same family. Traditionally regarded as an anti-inflammatory cytokine, IL-11 also demonstrates its role as a proinflammatory cytokine, suggesting its complex role in immune response. In recent years, IL-11 has an emerging role in various inflammation-associated cancers. In this review, we aim to discuss IL-11 signaling pathway, to explore the role of IL-11 in immunity and various cancers, and to provide a therapeutic perspective of strategies utilized to interfere IL-11 signaling in cancer cells.
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, USA.
authors.forename: Dixon H
authors.initials: DH
authors.lastname: Xu
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
authors.forename: Ziwen
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Wakefield
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, USA; The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, China.
authors.forename: Huaping
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Bai
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, USA; Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA. Electronic address: yujiang.fang@dmu.edu.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000818:Animals; D006801:Humans; D007109:Immunity; D017370:Interleukin-11 / Q000502:physiology*; D007377:Interleukin-3 / Q000502:physiology; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes / Q000502:physiology; D009369:Neoplasms / Q000276:immunology*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D050796:STAT3 Transcription Factor / Q000502:physiology; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000502:physiology
chemical_list: D017370:Interleukin-11; D007377:Interleukin-3; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D050796:STAT3 Transcription Factor; D058570:TOR Serine-Threonine Kinases
keywords: Cancer; Cytokine; IL-11; Immune response