title: Epigenetic ON/OFF Switches for Obesity.
abstract: Heritable epigenetic mechanisms might contribute to the worldwide increase in the prevalence of obesity. Dalgaard et al. identify an epigenetic molecular switch that controls body weight control. The discovery suggests the existence of mammalian polyphenism in energy metabolism and might have implications for strategies to limit the obesity epidemic.
authors.affiliation: Helmholtz Diabetes Center & German Diabetes Center (DZD), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Technische Universität München, 80333 Munich, Germany.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Quarta
authors.affiliation: Institute of Functional Epigenetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany; IGBMC, Strasbourg, 67400 Illkirch, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Schneider
authors.affiliation: Helmholtz Diabetes Center & German Diabetes Center (DZD), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Technische Universität München, 80333 Munich, Germany. Electronic address: tschoep@helmholtz-muenchen.de.
authors.forename: Matthias H
authors.initials: MH
authors.lastname: Tschöp
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D057895:Haploinsufficiency; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D013851:Thinness / Q000235:genetics*
chemical_list: D009687:Nuclear Proteins; D012097:Repressor Proteins