title: MANAGEMENT OF METASTATIC COLORECTAL CANCER: Current Treatments and New Therapies.
abstract: Colorectal cancer represents 8% of metastatic cancers. For decades, the gold standard therapy has been infusional chemotherapy with 5-Fluorouracil (5-FU) associated to folinic acid. The discovery of irinotecan, oxaliplatin and oral forms of 5-FU in the nineties is considered a milestone in the treatment of this disease. Since 2004, targeted therapy with monoclonal antibodies including anti-EGFR and angiogenesis inhibitors showed superiority in terms of mortality compared to conventional therapy. Metastatic colorectal cancer, however, remains an incurable disease. We present the current treatments of metastatic colorectal cancer, the clinical development of these emerging treatments, and their position in the Lebanese health care system.
authors.forename: Anna-Maria
authors.initials: AM
authors.lastname: Henaine
authors.forename: Georges
authors.initials: G
authors.lastname: Chahine
authors.forename: Pascale
authors.initials: P
authors.lastname: Salameh
authors.forename: Edouard
authors.initials: E
authors.lastname: Elias
authors.forename: Marcel
authors.initials: M
authors.lastname: Massoud
authors.forename: Daniel
authors.initials: D
authors.lastname: Hartmann
authors.forename: Gilles
authors.initials: G
authors.lastname: Aulagner
authors.forename: Xavier
authors.initials: X
authors.lastname: Armoiry
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000628:therapy*; D003663:Decision Trees; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents