title: Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding.
abstract: Transport of different intracellular cargoes along cytoskeleton filaments is essential for the morphogenesis and function of a broad variety of eukaryotic cells. Intracellular transport is mediated by cytoskeletal motors including myosin, kinesin, and dynein, which are typically linked to various cargoes by adaptor proteins. Recent studies suggest that adaptor proteins can also act as essential transport cofactors, which control motor activity and coordination. Characterization of the evolutionary conserved Bicaudal D (BICD) family of dynein adaptor proteins has provided important insights into the fundamental mechanisms governing cargo trafficking. This review highlights the advances in the current understanding of how BICD adaptors regulate microtubule-based transport and how they contribute to developmental processes and human disease.
authors.affiliation: Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, Utrecht, CH 3584 The Netherlands. Electronic address: c.hoogenraad@uu.nl.
authors.forename: Casper C
authors.initials: CC
authors.lastname: Hoogenraad
authors.affiliation: Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, Utrecht, CH 3584 The Netherlands. Electronic address: a.akhmanova@uu.nl.
authors.forename: Anna
authors.initials: A
authors.lastname: Akhmanova
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D004398:Dyneins / Q000378:metabolism*; D006801:Humans; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D021381:Protein Transport; D013329:Structure-Activity Relationship
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004398:Dyneins
keywords: adaptor; bicaudal; dynein; kinesin; mRNA transport; microtubule; vesicle transport