title: A new hexacyclic triterpene acid from the roots of Euscaphis japonica and its inhibitory activity on triglyceride accumulation.
abstract: A new taraxerene-type hexacyclic triterpene acid named (12R,13S)-3-methoxy-12,13-cyclo-taraxerene-2,14-diene-1-one-28-oic acid (1), together with a known compound 3,7-dihydroxy-5-octanolide (2), was isolated from the roots of Euscaphis japonica. The structure of new compound 1 was elucidated on the basis of NMR, HR-ESIMS and X-ray diffraction analysis. It showed promising inhibitory activity on oleic acid induced triglyceride accumulation on HepG2 cells.
authors.affiliation: Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Wuhan 430062, China; Hubei Key Laboratory of Bio-Technology of Traditional Chinese Medicine, Hubei University, Wuhan 430062, China.
authors.forename: Yan-Ci
authors.initials: YC
authors.lastname: Li
authors.affiliation: Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Wuhan 430062, China; Hubei Key Laboratory of Bio-Technology of Traditional Chinese Medicine, Hubei University, Wuhan 430062, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Tian
authors.affiliation: Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Wuhan 430062, China; Hubei Key Laboratory of Bio-Technology of Traditional Chinese Medicine, Hubei University, Wuhan 430062, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Sun
authors.affiliation: Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Wuhan 430062, China; Hubei Key Laboratory of Bio-Technology of Traditional Chinese Medicine, Hubei University, Wuhan 430062, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Long
authors.affiliation: Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Wuhan 430062, China; Hubei Key Laboratory of Bio-Technology of Traditional Chinese Medicine, Hubei University, Wuhan 430062, China; Shenzhen Institute of Geriatrics, Shenzhen 518020, China. Electronic address: lijunhuda@163.com.
authors.forename: Lu-Jun
authors.initials: LJ
authors.lastname: Li
authors.affiliation: Shenzhen Institute of Geriatrics, Shenzhen 518020, China. Electronic address: szwzz001@163.com.
authors.forename: Zheng-Zhi
authors.initials: ZZ
authors.lastname: Wu
mesh_terms: D056945:Hep G2 Cells; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D014280:Triglycerides / Q000032:analysis*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: C000608999:3-methoxy-12,13-cyclo-taraxerene-2,14-diene-1-one-28-oic acid; D014280:Triglycerides; D014315:Triterpenes
keywords: Euscaphis japonica; HepG2; Triglyceride accumulation; Triterpene acid