title: Dopamine Modulation of Intertemporal Decision-making: Evidence from Parkinson Disease.
abstract: Choosing between smaller prompt rewards and larger later rewards is a common choice problem, and studies widely agree that frontostriatal circuits heavily innervated by dopamine are centrally involved. Understanding how dopamine modulates intertemporal choice has important implications for neurobiological models and for understanding the mechanisms underlying maladaptive decision-making. However, the specific role of dopamine in intertemporal decisions is not well understood. Dopamine may play a role in multiple aspects of intertemporal choices--the valuation of choice outcomes and sensitivity to reward delays. To assess the role of dopamine in intertemporal decisions, we tested Parkinson disease patients who suffer from dopamine depletion in the striatum, in either high (on medication, PDON) or low (off medication, PDOFF) dopaminergic states. Compared with both PDOFF and healthy controls, PDON made more farsighted choices and reduced their valuations less as a function of increasing time to reward. Furthermore, reduced discounting in the high dopaminergic state was robust across multiple measures, providing new evidence for dopamine's role in making decisions about the future.
authors.affiliation: New York University.
authors.forename: Karin
authors.initials: K
authors.lastname: Foerde
authors.affiliation: Radboud University Nijmegen.
authors.forename: Bernd
authors.initials: B
authors.lastname: Figner
authors.affiliation: New York University.|Columbia University.
authors.forename: Bradley B
authors.initials: BB
authors.lastname: Doll
authors.affiliation: Radboud University Nijmegen.
authors.forename: Isabel C
authors.initials: IC
authors.lastname: Woyke
authors.affiliation: Columbia University.
authors.forename: Erin Kendall
authors.initials: EK
authors.lastname: Braun
authors.affiliation: Columbia University.
authors.forename: Elke U
authors.initials: EU
authors.lastname: Weber
authors.affiliation: Columbia University.
authors.forename: Daphna
authors.initials: D
authors.lastname: Shohamy
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003657:Decision Making / Q000187:drug effects*; D065786:Delay Discounting / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism*; D018491:Dopamine Agonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D012201:Reward
chemical_list: D018491:Dopamine Agonists; D004298:Dopamine