title: Integrated optofluidic-microfluidic twin channels: toward diverse application of lab-on-a-chip systems.
abstract: Optofluidics, which integrates microfluidics and micro-optical components, is crucial for optical sensing, fluorescence analysis, and cell detection. However, the realization of an integrated system from optofluidic manipulation and a microfluidic channel is often hampered by the lack of a universal substrate for achieving monolithic integration. In this study, we report on an integrated optofluidic-microfluidic twin channels chip fabricated by one-time exposure photolithography, in which the twin microchannels on both surfaces of the substrate were exactly aligned in the vertical direction. The twin microchannels can be controlled independently, meaning that fluids could flow through both microchannels simultaneously without interfering with each other. As representative examples, a tunable hydrogel microlens was integrated into the optofluidic channel by femtosecond laser direct writing, which responds to the salt solution concentration and could be used to detect the microstructure at different depths. The integration of such optofluidic and microfluidic channels provides an opportunity to apply optofluidic detection practically and may lead to great promise for the integration and miniaturization of Lab-on-a-Chip systems.
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Lv
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xia
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guan
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
authors.forename: Yun-Lu
authors.initials: YL
authors.lastname: Sun
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
authors.forename: Zhen-Nan
authors.initials: ZN
authors.lastname: Tian
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
authors.forename: Tong
authors.initials: T
authors.lastname: Jiang
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
authors.forename: Ying-Shuai
authors.initials: YS
authors.lastname: Wang
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
authors.forename: Yong-Lai
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
authors.forename: Qi-Dai
authors.initials: QD
authors.lastname: Chen
authors.affiliation: International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, 305-0044 Japan.|Precursory Research for Embryonic Science and Technology (PRESTO) and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Ariga
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China.
authors.forename: Yu-De
authors.initials: YD
authors.lastname: Yu
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.|College of Physics, Jilin University, 119 Jiefang Road, Changchun, 130023, People's Republic of China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Sun
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D020100:Hydrogels / Q000737:chemistry; D056656:Lab-On-A-Chip Devices; D007834:Lasers; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D055095:Optics and Photonics / Q000295:instrumentation* / Q000379:methods
chemical_list: D020100:Hydrogels
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