title: Pharmacological activities and structure-modification of resveratrol analogues.
abstract: Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a well-known natural polyphenol compound. It is reported that resveratrol possesses strong anti-oxidative, anti-inflammatory, cardiovascular protective and cancer chemo-preventive effects. Therefore, there has been a considerable interest in its biological activity, pharmacological activity and also synthetic resveratrol analogues in recent years. Up to now, many new resveratrol derivatives have been synthesized and some new biological activities of these compounds have been found, so in the treatment of Alzheimer's disease and the inhibition of influenza H1N1 neuraminidase. Structure-activity studies revealed that crucial elements of parental components are required for specific effects. This review summarizes the available literatures on the structure-activity relationships and pharmacological properties of resveratrol analogues.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.forename: Hongfei
authors.initials: H
authors.lastname: Chen
authors.forename: Chen
authors.initials: C
authors.lastname: Song
authors.forename: Xianliang
authors.initials: X
authors.lastname: Zeng
authors.forename: Qutong
authors.initials: Q
authors.lastname: Zheng
authors.forename: Yinxiang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Lei
authors.forename: Xing
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001555:Benzene Derivatives / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D001555:Benzene Derivatives; D006571:Heterocyclic Compounds; D013267:Stilbenes; D000077185:Resveratrol