title: [THE TREATMENT OF PATIENTS FOR ULCERATIVE-NECROTIC DEFECTS IN CHRONIC ISCHEMIA OF THE LOWER EXTREMITY TISSUES, USING BIOTECHNOLOGICAL METHODS].
abstract: The results of treatment of 53 patients, suffering "unreconstructable" affection of the lower extremities (LE) arteries and ulcerative-necrotic defects in their distal parts tissues, were analyzed. In 33 patients (the main group) the allotted mononuclear cells fraction, the bone marrow and the plasm, enhanced by thrombocytes, were applied, using multiple injections along a perimeter and into the bottom of the ulcerative-trophic defect in combination with autotransplantation of the bone marrow aspirate into the ischemized tissues--the shin muscles; in 20 patients (the comparison group)--the autotransplantation of the bone marrow aspirate was accomplished into the ischemized tissues--the shin and the foot muscles. In terms up to 3 mo postoperatively a clinical improvement in the main group was noted in 25 (75.7%) patients, the bearing function of the LE was preserved in 90.9%; and in the comparison group--accordingly, in 8 (40%) and 70%. In 36 mo in the main group the bearing function of the LE was preserved in 75.7% patients, and in the comparison group--in 50%. Application of the biotechnological methods proposed in patients, suffering ulcerative-necrotic defects in chronic ischemia of the LE tissues, have promoted the angiogenesis processes activation, the tissues reparation and regeneration, the wounds healing, and the disease clinical course optimization.
authors.forename: V I
authors.initials: VI
authors.lastname: Kirimov
authors.forename: I E
authors.initials: IE
authors.lastname: Barna
authors.forename: N F
authors.initials: NF
authors.lastname: Dryuk
authors.forename: I P
authors.initials: IP
authors.lastname: Dmitrenko
mesh_terms: D000368:Aged; D017130:Angioplasty / Q000379:methods*; D016026:Bone Marrow Transplantation; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D002908:Chronic Disease; D005260:Female; D016523:Foot Ulcer / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007511:Ischemia / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D035002:Lower Extremity / Q000098:blood supply / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal; D018919:Neovascularization, Physiologic; D014182:Transplantation, Autologous; D014945:Wound Healing