title: Antimicrobial stewardship for carbapenem use at a Japanese tertiary care center: An interrupted time series analysis on the impact of infectious disease consultation, prospective audit, and feedback.
abstract: Given the concerns surrounding the overuse of carbapenem antibiotics in Japan, we evaluated the impact of infectious disease consultation and a prospective carbapenem audit at a tertiary care center in Tokyo, Japan. Overall, carbapenem use was safely and effectively reduced after implementation of these interventions. The leadership of the infectious diseases physicians also proved critically important to implementing effective stewardship.
authors.affiliation: Department of Infection Prevention, Tokyo Metropolitan Tama General Medical Center, Tokyo, Japan; Division of Infectious Diseases, Tokyo Metropolitan Tama General Medical Center, Tokyo, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Tagashira
authors.affiliation: Department of Infection Prevention, Tokyo Metropolitan Tama General Medical Center, Tokyo, Japan.
authors.forename: Mikihiro
authors.initials: M
authors.lastname: Horiuchi
authors.affiliation: Japan Community Healthcare Organization, Tokyo, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tokuda
authors.affiliation: Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Heist
authors.affiliation: Department of Infection Prevention, Tokyo Metropolitan Tama General Medical Center, Tokyo, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Higuchi
authors.affiliation: Department of Infection Prevention, Tokyo Metropolitan Tama General Medical Center, Tokyo, Japan; Division of Infectious Diseases, Tokyo Metropolitan Tama General Medical Center, Tokyo, Japan. Electronic address: hondah@hotmail.com.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015780:Carbapenems / Q000627:therapeutic use*; D003141:Communicable Diseases / Q000188:drug therapy*; D004363:Drug Utilization / Q000592:standards*; D005246:Feedback; D006801:Humans; D065186:Interrupted Time Series Analysis; D016134:Organizational Policy; D012017:Referral and Consultation; D062606:Tertiary Care Centers; D014041:Tokyo
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems
keywords: Antimicrobial stewardship; carbapenem antimicrobials; infectious diseases consultation; prospective audit and feedback