title: Macrocycle Synthesis by Chloride-Templated Amide Bond Formation.
abstract: A new family of pseudopeptidic macrocyclic compounds has been prepared involving an anion-templated amide bond formation reaction at the macrocyclization step. Chloride anion was found to be the most efficient template in the macrocyclization process, producing improved macrocyclization yields with regard to the nontemplated reaction. The data suggest a kinetic effect of the chloride template, providing an appropriate folded conformation of the open-chain precursor and reducing the energy barrier for the formation of the macrocyclic product.
authors.affiliation: Departamento de Química Inorgánica y Orgánica, Universitat Jaume I , Avenida de Vicent Sos Baynat s/n, 12071 Castellón, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Martí-Centelles
authors.affiliation: Departamento de Química Inorgánica y Orgánica, Universitat Jaume I , Avenida de Vicent Sos Baynat s/n, 12071 Castellón, Spain.
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Burguete
authors.affiliation: Departamento de Química Inorgánica y Orgánica, Universitat Jaume I , Avenida de Vicent Sos Baynat s/n, 12071 Castellón, Spain.
authors.forename: Santiago V
authors.initials: SV
authors.lastname: Luis