title: Note: Magnetic targeting for enhancement of the activation efficiency of G protein-coupled receptor with a two-pair coil system.
abstract: Insufficient contact of drug with target cells is a primary reason for limited efficiency of G protein-coupled receptor activation. To overcome this limitation, a simple approach based on magnetic targeting for enhancing drug delivery towards the cell surfaces using magnetic nanoparticles and a two-pair coil system consisting of Helmholtz and Maxwell coils was reported. As a proof of the concept, comparative experiments on G protein-coupled receptor activation process were carried out and results show that the efficiency of G protein-coupled receptor activation can be increased about 6 times in the experiments with the aid of the proposed magnetic targeting system.
authors.affiliation: Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Quanliang
authors.initials: Q
authors.lastname: Cao
authors.affiliation: Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Xiaotao
authors.initials: X
authors.lastname: Han
authors.affiliation: School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chun
authors.affiliation: School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D060526:Magnetic Fields; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D043562:Receptors, G-Protein-Coupled