title: Effects of osteoformin in the rapid distraction osteogenesis of rabbit mandibles.
abstract: OBJECTIVE
  To evaluate the effects of osteoformin on mineralisation and quality of the new bone formation during rapid distraction osteogenesis.
  
  
  METHODS
  This multi-centre study was conducted at the Karadeniz Technical University, Middle East Technical University and Selcuk University. The experimental study was conducted from January 2010 to September 2012 and comprised New-Zealand rabbits that were randomly divided into three groups. In group I distraction rate was 1 mm/day while in groups II and III distraction rates were 2mm/day and 1 mm/day. In groups I and II 100µg/kg osteoformin was injected after the latency period. Distraction region was evaluated by radiological, histomorphometrical and dual energy X-ray absorptiometry analyses. SPSS 17 was used for statistical analysis.
  
  
  RESULTS
  There were 18 rabbits with each of three groups having 6(33.3%). Accelerated bone healing was noted in groups I and II compared with group III (p<0.05). No significant differences were indicated between groups I and II (p>0.05).
  
  
  CONCLUSIONS
  Local injection of osteoformin was effective in the craniomaxillofacial distraction osteogenesis in rabbits. Further experimental studies are recommended before using osteoformin on humans.
authors.affiliation: Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey.
authors.forename: Ezher Hamza
authors.initials: EH
authors.lastname: Dayisoylu
authors.affiliation: Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Pampu
authors.affiliation: Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey.
authors.forename: Figen Cizmeci
authors.initials: FC
authors.lastname: Senel
authors.affiliation: Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey.
authors.forename: Ercument
authors.initials: E
authors.lastname: Onder
authors.affiliation: Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey.
authors.forename: Dogan
authors.initials: D
authors.lastname: Dolanmaz
authors.affiliation: Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey.
authors.forename: Nuray Yilmaz
authors.initials: NY
authors.lastname: Altintas
authors.affiliation: Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bahcelievler, Ankara, Turkey.
authors.forename: Mustafa Cihat
authors.initials: MC
authors.lastname: Avunduk
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D001861:Bone Regeneration / Q000187:drug effects*; D004195:Disease Models, Animal; D017102:Fracture Healing / Q000187:drug effects*; D008334:Mandible / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery; D019857:Osteogenesis, Distraction / Q000379:methods*; D010455:Peptides / Q000008:administration & dosage*; D011817:Rabbits; D011859:Radiography / Q000379:methods; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D010455:Peptides; C017645:polyaspartate
keywords: Distraction osteogenesis, Bone healing, Negatively-charged peptide, Distraction rate, Animal model.