title: Retrospective analysis of adult patients with acute lymphoblastic leukemia undergoing allogeneic hematopoietic cell transplantation: A multicenter experience of daily practice.
abstract: Compared to pediatric age group, the prognosis of adult acute lymphoblastic leukemia (ALL) is still dismal even in patients receiving allogeneic hematopoietic cell transplantation (AHCT). We retrospectively analyzed 205 adults (male: 122; female: 83) with ALL who underwent AHCT. Median age of patients was 28 (18-59). Fifty-two patients had Ph(+) ALL. The estimated relapse-free and overall survival (OS) of the study cohort at 1, 2 and 3 years were 52.3%/63.9%, 42.9%/49.5% and 39.9%/45.6%, respectively. On multivariate analysis, first complete remission at the time of AHCT, TBI-based conditioning and development of chronic graft-versus-host disease were only factors, which were significantly associated with prolonged OS.
authors.affiliation: Hematology and Stem Cell Transplantation Clinic, Ankara Oncology Education and Research Hospital, Ankara, Turkey. Electronic address: emretekgunduz@yahoo.com.
authors.forename: Emre
authors.initials: E
authors.lastname: Tekgündüz
authors.affiliation: Division of Hematology, Department of Internal Medicine, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Leylagül
authors.initials: L
authors.lastname: Kaynar
authors.affiliation: Division of Hematology, Department of Internal Medicine, Hacettepe University Medical Faculty, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Göker
authors.affiliation: Hematology and Stem Cell Transplantation Clinic, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Ali Hakan
authors.initials: AH
authors.lastname: Kaya
authors.affiliation: Division of Hematology, Department of Internal Medicine, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Esra Ermiş
authors.initials: EE
authors.lastname: Turak
authors.affiliation: Division of Hematology, Department of Internal Medicine, Hacettepe University Medical Faculty, Ankara, Turkey.
authors.forename: Eylem
authors.initials: E
authors.lastname: Eliaçık
authors.affiliation: Hematology and Stem Cell Transplantation Clinic, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Ömür
authors.initials: Ö
authors.lastname: Kayıkçı
authors.affiliation: Division of Hematology, Department of Internal Medicine, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çetin
authors.affiliation: Division of Hematology, Department of Internal Medicine, Hacettepe University Medical Faculty, Ankara, Turkey.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Büyükaşık
authors.affiliation: Division of Hematology, Department of Internal Medicine, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Eser
authors.affiliation: Hematology and Stem Cell Transplantation Clinic, Ankara Oncology Education and Research Hospital, Ankara, Turkey; Division of Hematology, Department of Internal Medicine, Yıldırım Beyazıt University Medical Faculty, Ankara, Turkey.
authors.forename: Fevzi
authors.initials: F
authors.lastname: Altuntaş
mesh_terms: D000293:Adolescent; D000328:Adult; D003710:Demography; D005260:Female; D006086:Graft vs Host Disease / Q000401:mortality; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality / Q000628:therapy*; D012074:Remission Induction; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
keywords: ALL; Acute lymphoblastic leukemia; Allogeneic; HCT; Hematopoietic cell transplantation