title: Alteration of nuclear factor-kappaB pathway promote neuroinflammation depending on the functions of estrogen receptors in substantia nigra after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment.
abstract: The simultaneous role of neuroprotective estrogen and neurodegenerative inflammation during the progression of Parkinson's disease (PD) is still remaining elusive. The novel importance of the present study in MPTP mediated mouse model of Parkinson's disease (PD) is-to investigate the status of neuronal and glial cells in a time chase experiment; to explore which pathway of NF-kappaB exist to proceed the neuroinflammation; to investigate the status of estrogen and the activation pattern of nuclear or cytosolic estrogen receptors in either sexes of Swiss albino mice during MPTP mediated progressive neurodegeneration in the substantia nigra. After MPTP intoxication, the nigral molecular anatomy was changed differently in separate time interval during the progression of neurodegeneration with/without association of glial cells and functional (via its nuclear and cytosolic receptors) estrogen level. Both the canonical and/or non-canonical pathways of NF-kappaB exist in the substantia nigra of both the sexes after MPTP treatment that is why inspite of presence of estrogen, neuroinflammation progresses. The homodimeric or heterodimeric form of ER-beta binds with NF-kappaB molecules p65 and RelB differently, but the canonical or non-canonical pathways of NF-kappaB molecules could not be stopped or may be promoted.
authors.affiliation: Immunology Lab, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India. Electronic address: soham_envs@yahoo.co.in.
authors.forename: Soham
authors.initials: S
authors.lastname: Mitra
authors.affiliation: Immunology Lab, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India. Electronic address: ngdiya@gmail.com.
authors.forename: Nabanita
authors.initials: N
authors.lastname: Ghosh
authors.affiliation: Department of Physiology, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata 700009, India. Electronic address: priyobiochem@gmail.com.
authors.forename: Priyobrata
authors.initials: P
authors.lastname: Sinha
authors.affiliation: Department of Physiology, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata 700009, India. Electronic address: nilchakra@hotmail.com.
authors.forename: Nilkanta
authors.initials: N
authors.lastname: Chakrabarti
authors.affiliation: Immunology Lab, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India. Electronic address: arindam19@yahoo.com.
authors.forename: Arindam
authors.initials: A
authors.lastname: Bhattacharyya
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002452:Cell Count; D004195:Disease Models, Animal; D004296:Dopa Decarboxylase / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D008297:Male; D051379:Mice; D008840:Microfilament Proteins / Q000378:metabolism; D017628:Microglia / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology / Q000473:pathology; D010300:Parkinson Disease / Q000209:etiology / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D012737:Sex Factors; D013378:Substantia Nigra / Q000378:metabolism*; D051996:Transcription Factor RelA / Q000378:metabolism; D051841:Transcription Factor RelB / Q000378:metabolism
chemical_list: C100745:Aif1 protein, rat; D002135:Calcium-Binding Proteins; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D005904:Glial Fibrillary Acidic Protein; D008840:Microfilament Proteins; D016328:NF-kappa B; D011960:Receptors, Estrogen; C497595:Relb protein, rat; D051996:Transcription Factor RelA; D051841:Transcription Factor RelB; D004958:Estradiol; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004296:Dopa Decarboxylase
keywords: Astrocyte; Estrogen; Estrogen receptor; MPTP; Microglia; NF‐kappaB; Substantia nigra