title: C-Kit-Negative Gastrointestinal Stromal Tumor in the Stomach.
abstract: C-kit-negative gastrointestinal stromal tumors (GISTs) are uncommon, and there have been few reports about the diagnosis and treatment of c-kit-negative GISTs in the stomach. We report the case of a patient who was diagnosed with a huge and atypical GIST in the stomach. The GIST was completely resected and finally diagnosed as c-kit-negative GIST based on immunohistochemical staining of tumor cells, which were negative for CD117 and CD34 and positive for Discovered on GIST-1 (DOG1). C-kit-negative GISTs could be treated by complete resection and/or imatinib, which is the same treatment for c-kit-positive GISTs.
authors.affiliation: Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ho Seok
authors.initials: HS
authors.lastname: Seo
authors.affiliation: Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Hyeon
authors.affiliation: Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Ok-Ran
authors.initials: OR
authors.lastname: Shin
authors.affiliation: Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea, Seoul, Korea.
authors.forename: Han Hong
authors.initials: HH
authors.lastname: Lee
keywords: C-kit protein; DOG1 protein; Gastrointestinal stromal tumors
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