title: Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis.
abstract: Psoriasis is a chronic papulosquamous skin disease, histologically characterized by epidermal hyperproliferation and dermal infiltration of inflammatory cells. The majority of T lymphocytes infiltrating dermis are CD4+ T lymphocytes secreting type 1 and type 17 cytokines. These cytokines are responsible for triggering keratinocyte proliferation as well as chemokine secretion and subsequent migration of other inflammatory cells in the skin. Contrarily, lymphocytes that accumulate in epidermis are mainly CD8+ T lymphocytes. According to the recent findings, these cells can also secrete type 1 and type 17 cytokines. However, it is demonstrated so far that epidermal CD8+ T lymphocytes contain higher amounts of cytolytic molecules, such as perforin, granzyme B and granulysin whose role in psoriasis pathogenesis is still unknown. Therefore, in this article we hypothesize the active involvement of cell mediated cytotoxicity in killing the proliferating keratinocytes as a mechanism of potential self-defense and possible brake in psoriatic plaque formation, maintaining skin homeostasis.
authors.affiliation: Department of Dermatovenerology, Clinical Hospital Center Rijeka, Medical Faculty, University of Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
authors.forename: Marijana
authors.initials: M
authors.lastname: Vičić
authors.affiliation: Department of Dermatovenerology, Clinical Hospital Center Rijeka, Medical Faculty, University of Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Peternel
authors.affiliation: Department of Dermatovenerology, Clinical Hospital Center Rijeka, Medical Faculty, University of Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
authors.forename: Edita
authors.initials: E
authors.lastname: Simonić
authors.affiliation: Department of Physiology and Immunology, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
authors.forename: Vlatka
authors.initials: V
authors.lastname: Sotošek-Tokmadžić
authors.affiliation: Division of Rheumatology and Physical Medicine, Hospital for Medical Rehabilitation of the Hearth and Lung Diseases and Rheumatism "Thalassotherapia" Opatija, M. Tita 188, 51410 Opatija, Croatia.
authors.forename: Dražen
authors.initials: D
authors.lastname: Massari
authors.affiliation: Department of Dermatovenerology, Clinical Hospital Center Rijeka, Medical Faculty, University of Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
authors.forename: Ines
authors.initials: I
authors.lastname: Brajac
authors.affiliation: Department of Dermatovenerology, Clinical Hospital Center Rijeka, Medical Faculty, University of Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
authors.forename: Marija
authors.initials: M
authors.lastname: Kaštelan
authors.affiliation: Department of Dermatovenerology, Clinical Hospital Center Rijeka, Medical Faculty, University of Rijeka, Krešimirova 42, 51000 Rijeka, Croatia. Electronic address: larisa.prpic@medri.uniri.hr.
authors.forename: Larisa
authors.initials: L
authors.lastname: Prpić-Massari
mesh_terms: D016923:Cell Death / Q000276:immunology; D049109:Cell Proliferation; D016207:Cytokines / Q000096:biosynthesis; D003602:Cytotoxicity, Immunologic; D006801:Humans; D015603:Keratinocytes / Q000473:pathology*; D018448:Models, Immunological; D011565:Psoriasis / Q000209:etiology / Q000276:immunology* / Q000473:pathology*; D012867:Skin / Q000276:immunology / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000473:pathology*
chemical_list: D016207:Cytokines