title: Non-ionic macroporous polystyrene adsorbents for removal of serum toxins in liver failure by hemoperfusion.
abstract: Strong base anion exchange resin (e.g., BL-300) is currently used to eliminate bilirubin from blood in clinical hemoperfusion. However, there is a potential weakness of the resin to remove heparin and activation of coagulation. To overcome this weakness, we prepared a novel non-ionic macroporous polystyrene adsorbent (SZ-9) with rich mesopores and high surface area by suspension polymerization. Test results indicated that SZ-9 performed better adsorption capacity for bilirubin than BL-300. In addition, better blood compatibility was observed during whole blood hemoperfusion. Therefore, adsorbent SZ-9 might be an efficient alternative to anion exchange resin for the removal of bilirubin in hemoperfusion.
authors.affiliation: a The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences , Nankai University , Tianjin , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: a The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences , Nankai University , Tianjin , China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Han
authors.affiliation: b Institute of Hepatopathy Medical Research, the Second People's Hospital , Tianjin , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Su
authors.affiliation: a The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences , Nankai University , Tianjin , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: a The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences , Nankai University , Tianjin , China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Zong
authors.affiliation: a The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences , Nankai University , Tianjin , China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences , Nankai University , Tianjin , China.
authors.forename: Weichao
authors.initials: W
authors.lastname: Wang
authors.affiliation: a The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences , Nankai University , Tianjin , China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Cheng
authors.affiliation: a The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences , Nankai University , Tianjin , China.
authors.forename: Lailiang
authors.initials: L
authors.lastname: Ou
authors.affiliation: a The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences , Nankai University , Tianjin , China.
authors.forename: Yaoting
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000097:blood / Q000302:isolation & purification; D006464:Hemoperfusion / Q000379:methods*; D017093:Liver Failure / Q000097:blood* / Q000628:therapy*; D008422:Materials Testing; D011137:Polystyrenes / Q000737:chemistry*; D016062:Porosity; D011817:Rabbits
chemical_list: D011137:Polystyrenes; D001663:Bilirubin
keywords: Blood purification; liver failure; non-ionic adsorbents; polystyrenel serum toxins