title: Biomarkers in psoriatic arthritis: a systematic literature review.
abstract: Psoriatic arthritis (PsA) is characterized by chronic inflammation of peripheral joints and axial skeleton, associated with a strong genetic background. Clinics include enthesitis or dactylitis and extra-articular involvement as uveitis or inflammatory bowel disease, while treatment options range from nonsteroidal anti-inflammatory drugs (NSAIDs) to biologics, targeting TNF α or Th17. No serum autoantibody is associated with PsA, while other biomarkers have been proposed for early diagnosis or to predict treatment response. To better discuss this area of growing interest we performed a systematic review of the literature on biomarkers in PsA. Our research retrieved 408 papers, and 38 were included in the analysis. Based on the available literature, we draw some recommendations for the use of biomarkers in the management of patients with PsA.
authors.affiliation: a Division of Rheumatology and Clinical Immunology , Humanitas Research Hospital , Milan , Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Generali
authors.affiliation: b Epidemiology Unit , Italian Society for Rheumatology , Milan , Italy.
authors.forename: Carlo A
authors.initials: CA
authors.lastname: Scirè
authors.affiliation: c Department of Rheumatology , G. Pini Institute , Milan , Italy.
authors.forename: Ennio G
authors.initials: EG
authors.lastname: Favalli
authors.affiliation: a Division of Rheumatology and Clinical Immunology , Humanitas Research Hospital , Milan , Italy.|d BIOMETRA Department , University of Milan , Milan , Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Selmi
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D015535:Arthritis, Psoriatic / Q000175:diagnosis* / Q000235:genetics; D015415:Biomarkers / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D007596:Joints / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha
keywords: Psoriasis; autoantibodies; biologics; genetics; personalized medicine; spondyloarthritis