title: [ASSOCIATED RESPIRATORY AND HEMODYNAMICS RESPONSE TO ACUTE NORMOBARIC PROGRESSIVE HYPOXIA IN ANESTHETIZED RATS].
abstract: The interdependent reactions of the cardiorespiratory system during experimental simulation of progressive acute hypoxia were studied in anesthetized Wistar rats. The results indicate that the extremely low oxygen content in the inhaled gas mixture to less than 6% lead to terminal sedation and apnea. After the cessation of hypoxic exposure were observed spontaneous autoresuscitation. Effects of progressive hypoxia, is an example of a multi-component interdependent reactions of the cardiorespiratory system, which are based on the respiratory and vasomotor center function disturbance and the predominance of parasympathetic influences on the heart. The obtained data can be used as a model of hypoxic apnea to examine the influence of physiologically active substances on the cardiorespiratory system at disease pathology.
authors.forename: Zh A
authors.initials: ZhA
authors.lastname: Donina
authors.forename: E V
authors.initials: EV
authors.lastname: Baranova
authors.forename: N P
authors.initials: NP
authors.lastname: Aleksandrova
mesh_terms: D000768:Anesthesia, General; D018686:Anesthetics, Intravenous; D000818:Animals; D001049:Apnea / Q000139:chemically induced / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000187:drug effects; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D000860:Hypoxia / Q000503:physiopathology*; D010100:Oxygen / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D056152:Respiratory Rate / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects* / Q000503:physiopathology; D013990:Tidal Volume / Q000187:drug effects; D014520:Urethane; D014666:Vasomotor System / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D018686:Anesthetics, Intravenous; D014520:Urethane; D010100:Oxygen