title: Pupil response to tropicamide following corneal crosslinking.
abstract: OBJECTIVE
  To evaluate the effect of corneal crosslinking (CXL) with ultraviolet A (UVA) irradiation on pupil response to tropicamide 0.5% instillation.
  
  
  METHODS
  This prospective interventional study enrolled 17 patients (19 eyes) with progressive keratoconus who underwent CXL with UVA irradiation. Central corneal thickness (CCT) was evaluated with the use of anterior segment optical coherence tomography (Visante OCT 3.0). Pupil diameter was measured with the use of Colvard infrared pupillometer before the instillation of tropicamide 0.5% and after the instillation of tropicamide every 5 minutes for total duration of 30 minutes. Corneal epithelial integrity was examined with the use of fluorescein dye staining. Measurements were performed 1 day preoperatively and 1 month postoperatively, with emphasis on simulating the same light conditions regarding the pupil measurements.
  
  
  RESULTS
  No intraoperative or postoperative complications were observed in any of the patients. Mean CCT decreased significantly (p&lt;0.001) 1 month postoperatively. Mean postoperative pupil size did not change significantly at any time point compared to the mean preoperative measurements.
  
  
  CONCLUSIONS
  The CXL procedure seems not to impair effectiveness of topical drugs, using pupil size measurements after tropicamide 0.5% instillation.
authors.affiliation: Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete - Greece.
authors.forename: George D
authors.initials: GD
authors.lastname: Kymionis
authors.affiliation: Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete - Greece.
authors.forename: Theodore A
authors.initials: TA
authors.lastname: Paraskevopoulos
authors.affiliation: Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete - Greece.
authors.forename: Dimitrios A
authors.initials: DA
authors.lastname: Liakopoulos
authors.affiliation: Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete - Greece.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Grentzelos
authors.affiliation: Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete - Greece.
authors.forename: Anna I
authors.initials: AI
authors.lastname: Kouroupaki
authors.affiliation: Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete - Greece.
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Tsoulnaras
authors.affiliation: Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete - Greece.
authors.forename: Sophia I
authors.initials: SI
authors.lastname: Panagopoulou
authors.affiliation: Department of Medical, Surgical and Neurosciences, Siena University Hospital, Siena - Italy.
authors.forename: Cosimo
authors.initials: C
authors.lastname: Mazzotta
authors.affiliation: Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete - Greece.
authors.forename: Efstathios T
authors.initials: ET
authors.lastname: Detorakis
mesh_terms: D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000378:metabolism; D003319:Corneal Stroma / Q000378:metabolism*; D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D009184:Mydriatics / Q000008:administration & dosage*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects*; D012256:Riboflavin / Q000627:therapeutic use; D041623:Tomography, Optical Coherence / Q000379:methods; D014331:Tropicamide / Q000008:administration & dosage*; D014466:Ultraviolet Rays; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D009184:Mydriatics; D017319:Photosensitizing Agents; D003094:Collagen; D014331:Tropicamide; D012256:Riboflavin