title: [Case-control study of expansion of heart cavity and great vessel diameters in acromegaly].
abstract: OBJECTIVE
  To investigate alternations of heart cavity and great vessel diameters and their risk factors in acromegalic patients.
  
  
  METHODS
  Ninety-two cases, diagnosed as acromegaly, were selected as research subjects from January 2013 to December 2013 in Peking Union Medical College Hospital. There were 37 males and 55 females with an average age of 41.2 years (SD, 12.5 years, range from 19 to 67 years old). Ninety-two sex and age matched healthy individuals were selected as controls. Disease history, echocardiography, endocrine hormone levels were collected to make contractive analysis. We analyzed the related risk factors of great vessel diameters expansion with binary logistic regression analysis and finally obtained the OR (odd ratio) and predictive formula.
  
  
  RESULTS
  Left ventricle end-diastolic diameter (LVEDD), left ventricle end-systolic diameter (LVESD), left atrium longitudinal dimension (LALD), right ventricle longitudinal dimension (RVLD), aortic root dimension (AORD), ascending aorta (AA), main pulmonary artery (MPA) were higher in patients with acromegaly than in healthy people, P<0.05. The comparison between expanded vessel diameters and normal vessel diameters in acromegalics showed that difference of disease duration was of statistical significance, OR= 1.011. We got the formula: logit (ADE)=-3.420+0.011 × duration of disease.
  
  
  CONCLUSIONS
  Heart cavity and vessel diameters in acromegalic patients were higher than that in public. Expanding of great vessel diameters mainly depend on duration of disease instead of serum GH and IGF-1 level, and the duration of disease is the risk factor of the expansion of great vessel diameters.
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Yilin
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Ligang
authors.initials: L
authors.lastname: Fang
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; Email: xingbingemail@aliyun.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Xing
mesh_terms: D000172:Acromegaly; D000328:Adult; D000368:Aged; D001011:Aorta; D001021:Aortic Valve; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D007334:Insulin-Like Growth Factor I; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D007334:Insulin-Like Growth Factor I