title: Clonal Relationships Between Malignant Lymphomas and Histiocytic/Dendritic Cell Tumors.
abstract: Tumors of histiocytic or dendritic cell origin appear to occur with increased frequency in patients with lymphoma. Recent molecular data have demonstrated clonal relationships between the lymphoma and the histiocytic/dendritic cell tumor in some of these cases. Clinical, pathologic, and experimental data suggest that this phenomenon probably represents transdifferentiation of the lymphoma clone to a histiocytic/dendritic cell lineage in most cases. Awareness of this entity is necessary to prompt comparative molecular studies in appropriate cases.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: feldman.andrew@mayo.edu.
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Feldman
keywords: Clonality; Dendritic cell tumor; Histiocytic sarcoma; Langerhans cell histiocytosis; Lineage plasticity; Transdifferentiation; Transformation