title: Fertility and pregnancy in the Fontan population.
abstract: BACKGROUND
  Women with a Fontan circulation are deemed at significantly increased risk of maternal morbidity and mortality during pregnancy. Publications describe a small number of pregnancies worldwide and a high rate of miscarriage. We compiled the experience of women enrolled in the Australia and New Zealand Fontan (ANZ) Registry with regard to menarche, contraceptive use, pregnancy advice and pregnancy outcomes.
  
  
  METHODS
  Women within the ANZ Fontan Registry were contacted and asked to consent to receiving sequential questionnaires.
  
  
  RESULTS
  156 women ≥ 18 years of age (including 4 deceased individuals) were identified, 101 women consented and 97 completed the initial questionnaire. Women were aged (median) 25 years (23-32); menarche occurred at a median 14 years (13-16). A wide variety of contraceptive methods was reported. 81% of women reported having received advice that pregnancy carried an increased risk or was inadvisable. Pregnancy was reported in a minority (n=27). Miscarriage (42.5%) and termination (7.5%) accounted for half the pregnancy outcomes and the babies were born early (median 31.5 weeks) and small (median 1350 g). Maternal complications of bleeding, arrhythmia and heart failure were reported with no early maternal mortality.
  
  
  CONCLUSIONS
  In women with a Fontan circulation the fertility onset is delayed and pregnancy has a higher rate of miscarriage. Successful pregnancy resulted in small and premature babies. Significant maternal morbidity occurred. Whether pregnancy with its volume loading has an adverse effect on the long-term outcome of women with a single ventricle remains to be elucidated.
authors.affiliation: Department of Cardiology, Royal Melbourne Hospital, Australia. Electronic address: dominica.zentner@mh.org.au.
authors.forename: Dominica
authors.initials: D
authors.lastname: Zentner
authors.affiliation: Department of Cardiothoracic Surgery, Royal Children's Hospital, Australia; Murdoch Children's Research Institute, Australia.
authors.forename: Aneta
authors.initials: A
authors.lastname: Kotevski
authors.affiliation: Department of Cardiothoracic Surgery, Royal Children's Hospital, Australia; Murdoch Children's Research Institute, Australia.
authors.forename: Ingrid
authors.initials: I
authors.lastname: King
authors.affiliation: Department of Cardiology, Royal Melbourne Hospital, Australia.
authors.forename: Leeanne
authors.initials: L
authors.lastname: Grigg
authors.affiliation: Department of Cardiothoracic Surgery, Royal Children's Hospital, Australia; Murdoch Children's Research Institute, Australia; Department of Paediatrics, Faculty of Medicine, The University of Melbourne, Victoria, Australia.
authors.forename: Yves
authors.initials: Y
authors.lastname: d'Udekem
mesh_terms: D000293:Adolescent; D000328:Adult; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005298:Fertility; D005500:Follow-Up Studies; D018729:Fontan Procedure / Q000009:adverse effects / Q000639:trends*; D006801:Humans; D007231:Infant, Newborn; D009520:New Zealand / Q000453:epidemiology; D011159:Population Surveillance / Q000379:methods; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012042:Registries; D055815:Young Adult
keywords: Congenital heart disease; Contraception; Fontan circulation; Menarche; Pregnancy; Women