title: Diagnostic utility of PAX2 and PAX5 in distinguishing non-small cell lung cancer from small cell lung cancer.
abstract: Lung cancer is the leading cause of cancer-related death in both men and women and consists of different histological types. Histopathological examination and accurate subtype diagnosis has become increasingly important in guiding patient management and, as such, is the most important currently available lung cancer "biomarker". In this study, we examined the expression of PAX2 and PAX5 by immunohistochemistry in 47 cases of lung cancer and 13 cases of pneumonia. The results demonstrated that PAX2 were detected in 82.8% (24/29) of NSCLC, 0% (0/18) of SCLC and 7.7% (1/13) of pneumonia, respectively; However, PAX5 were detected in 15/18 cases (83.3%) of SCLC, 6.8% (2/29) of NSCLC and 7.7% (1/13) of pneumonia. Further, the samples with lymphatic metastasis had remarkable higher positive PAX2 or PAX5 than that without metastases. Overall, our data indicated that PAX2 and PAX5 differentially expressed in NSCLC and SCLC. Thus, PAX2 and PAX5 are useful biomarker in the differential diagnosis of lung cancer.
authors.affiliation: Department of Pulmonary Medicine, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
authors.forename: Yinlong
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Pulmonary Medicine, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
authors.forename: Junna
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Pulmonary Medicine, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
authors.forename: Aiguo
authors.initials: A
authors.lastname: Xu
authors.affiliation: Department of Pathology, Wuxi Medical School, Jiangnan UniversityWuxi 214122, Jiangsu, China; Department of Pathology, Affiliated Hospital, Jiangnan UniversityWuxi 214062, Jiangsu, China.
authors.forename: Yunbao
authors.initials: Y
authors.lastname: Pan
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D051762:PAX2 Transcription Factor / Q000032:analysis / Q000096:biosynthesis*; D051757:PAX5 Transcription Factor / Q000032:analysis / Q000096:biosynthesis*; D055752:Small Cell Lung Carcinoma / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D051762:PAX2 Transcription Factor; C497318:PAX2 protein, human; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human
keywords: Lung cancer; PAX2; PAX5; biomarker; immunohistochemistry
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