title: Tumor characteristics and therapy of elderly patients with breast cancer.
abstract: BACKGROUND
  Elderly breast cancer patients aged ≥75 years are underrepresented in most studies. Therefore, data on cancer characteristics, adjuvant treatment and survival in elderly patients are missing.
  
  
  METHODS
  In this retrospective study, we compared tumor characteristics and adjuvant therapy in 973 women with invasive, non-metastasized breast cancer aged ≥75 years with 3377 younger postmenopausal patients (50-74 years old). Time dynamics of tumor characteristics were investigated, comparing two observation periods between the years 2000-2004 versus 2005-2008.
  
  
  RESULTS
  Compared to younger women, older patients were more often treated with mastectomy and less likely to receive adjuvant treatment. Although the overall survival rate increased over the observation period in both age groups, the older study group was characterized by shorter disease-free survival. Additionally, we observed an increase in about 1.65 years in the age at diagnosis as well as an increasing rate of breast-conserving surgery and sentinel lymph node biopsy for the whole study population between 2000 and 2008. Furthermore, we found a reduction in the proportion of estrogen receptor-positive tumors in the younger women and a decrease in G3-tumors in both age groups over the study time.
  
  
  CONCLUSIONS
  The older group's reduced disease-free survival could be explained by the tumor characteristics and differences in the adjuvant treatment. Remarkably, elderly women are more likely to be overtreated surgically while being undertreated in terms of adjuvant therapy.
authors.affiliation: University Womens Hospital, Otto-von-Guericke University, Gerhard-Hauptmann-Str. 35, 39108, Magdeburg, Germany.
authors.forename: A-M
authors.initials: AM
authors.lastname: Grumpelt
authors.affiliation: University Womens Hospital, Otto-von-Guericke University, Gerhard-Hauptmann-Str. 35, 39108, Magdeburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Ignatov
authors.affiliation: University Womens Hospital, RWTH Aachen University, Aachen, Germany.
authors.forename: S N
authors.initials: SN
authors.lastname: Tchaikovski
authors.affiliation: Cancer Registry Magdeburg, Magdeburg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Burger
authors.affiliation: University Womens Hospital, Otto-von-Guericke University, Gerhard-Hauptmann-Str. 35, 39108, Magdeburg, Germany.
authors.forename: S-D
authors.initials: SD
authors.lastname: Costa
authors.affiliation: University Womens Hospital, Otto-von-Guericke University, Gerhard-Hauptmann-Str. 35, 39108, Magdeburg, Germany. holm.eggemann@med.ovgu.de.
authors.forename: H
authors.initials: H
authors.lastname: Eggemann
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human
keywords: Adjuvant treatment; Breast cancer; Elderly patients
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