title: Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study.
abstract: Purpose. The purpose of this study was to evaluate the regional synchronization of brain in patients with juvenile myoclonic epilepsy (JME). Methods. Resting-state fMRI data were acquired from twenty-one patients with JME and twenty-two healthy subjects. Regional homogeneity (ReHo) was used to analyze the spontaneous activity in whole brain. Two-sample t-test was performed to detect the ReHo difference between two groups. Correlations between the ReHo values and features of seizures were calculated further. Key Findings. Compared with healthy controls, patients showed significantly increased ReHo in bilateral thalami and motor-related cortex regions and a substantial reduction of ReHo in cerebellum and occipitoparietal lobe. In addition, greater ReHo value in the left paracentral lobule was linked to the older age of onset in patients. Significance. These findings implicated the abnormality of thalamomotor cortical network in JME which were associated with the genesis and propagation of epileptiform activity. Moreover, our study supported that the local brain spontaneous activity is a potential tool to investigate the epileptic activity and provided important insights into understanding the pathophysiological mechanisms of JME.
authors.affiliation: Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Sisi
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Luo
authors.affiliation: Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Zhixuan
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Changyue
authors.initials: C
authors.lastname: Hou
authors.affiliation: Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, China; Department of Neurology, Chongzhou People's Hospital, Chengdu 610000, China.
authors.forename: Pu
authors.initials: P
authors.lastname: Wang
authors.affiliation: Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Li
authors.initials: L
authors.lastname: Dong
authors.affiliation: Department of Neurology, Chongzhou People's Hospital, Chengdu 610000, China.
authors.forename: Chengqing
authors.initials: C
authors.lastname: Zhong
authors.affiliation: Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Yongxiu
authors.initials: Y
authors.lastname: Lai
authors.affiliation: Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000503:physiopathology*; D009415:Nerve Net / Q000503:physiopathology*; D055815:Young Adult
references.citation: Epilepsy Res. 2009 Dec;87(2-3):160-8
references.pmid: 19836209
references.citation: Adv Exp Med Biol. 2006;576:241-62; discussion 361-3
references.pmid: 16802717
references.citation: Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15236-40
references.pmid: 16217042
references.citation: J Neurol Sci. 2015 Jul 15;354(1-2):79-85
references.pmid: 25982500
references.citation: Epilepsy Behav. 2013 Jul;28 Suppl 1:S8-14
references.pmid: 23756488
references.citation: Neuroimage. 2004 May;22(1):394-400
references.pmid: 15110032
references.citation: Epilepsy Res. 2011 May;94(3):127-37
references.pmid: 21482074
references.citation: Neuroimage. 2007 Oct 1;37(4):1132-7
references.pmid: 17689105
references.citation: Neuroimage. 2013 Jan 15;65:374-86
references.pmid: 23085497
references.citation: Seizure. 2007 Jun;16(4):287-95
references.pmid: 17391993
references.citation: Epilepsy Res. 2014 Jan;108(1):125-38
references.pmid: 24246142
references.citation: Epilepsy Behav. 2004 Oct;5(5):696-701
references.pmid: 15380121
references.citation: Neurology. 2008 Dec 9;71(24):1981-5
references.pmid: 19064879
references.citation: Biomed Res Int. 2014;2014:960395
references.pmid: 25247197
references.citation: Clin Neurophysiol. 2001 Oct;112(10):1803-9
references.pmid: 11595137
references.citation: Nat Rev Neurosci. 2007 Sep;8(9):700-11
references.pmid: 17704812
references.citation: Brain. 2011 Jun;134(Pt 6):1710-9
references.pmid: 21616969
references.citation: Epilepsy Behav. 2013 Jul;28 Suppl 1:S40-4
references.pmid: 23756478
references.citation: Epilepsia. 2001 Jun;42(6):796-803
references.pmid: 11422340
references.citation: Epilepsy Behav. 2011 Aug;21(4):407-11
references.pmid: 21700499
references.citation: Epilepsia. 2013 Apr;54(4):658-66
references.pmid: 23294137
references.citation: Brain Res. 2010 Apr 6;1323:152-60
references.pmid: 20132802
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4637-42
references.pmid: 15070770
references.citation: Hum Brain Mapp. 2009 May;30(5):1502-10
references.pmid: 18649351
references.citation: J Neurosci. 1999 Jul 1;19(13):5632-43
references.pmid: 10377369
references.citation: Brain Res. 2010 Mar 19;1321:169-79
references.pmid: 20053346
references.citation: J Neurol Sci. 2014 Apr 15;339(1-2):189-95
references.pmid: 24642509
references.citation: Neuroimage Clin. 2015;7:98-104
references.pmid: 25610771
references.citation: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
references.pmid: 15976020
references.citation: Brain. 1998 Apr;121 ( Pt 4):561-79
references.pmid: 9577385
references.citation: Hum Brain Mapp. 2011 Aug;32(8):1290-9
references.pmid: 20665717
references.citation: Brain. 2014 Sep;137(Pt 9):2469-79
references.pmid: 25001494
references.citation: PLoS One. 2011;7(1):e28196
references.pmid: 22242146
references.citation: J Neurosci. 2010 Nov 24;30(47):15915-26
references.pmid: 21106830
references.citation: Hum Brain Mapp. 2012 Jun;33(6):1279-94
references.pmid: 21520351
references.citation: Epilepsy Res. 2008 Sep;81(1):58-68
references.pmid: 18547787
references.citation: Autism Res. 2016 Jan;9(1):43-54
references.pmid: 26058882
references.citation: Epilepsy Res. 2011 Nov;97(1-2):83-91
references.pmid: 21856123
references.citation: Psychiatry Res. 2010 Jun 30;182(3):211-5
references.pmid: 20493670
references.citation: Epilepsia. 2008 Feb;49(2):269-80
references.pmid: 17825075
references.citation: Front Aging Neurosci. 2014 Oct 29;6:280
references.pmid: 25400578
references.citation: J Neurol Sci. 2014 May 15;340(1-2):58-62
references.pmid: 24746024
references.citation: Child Dev. 2000 Jan-Feb;71(1):44-56
references.pmid: 10836557
references.citation: Acta Neurol Scand. 1985 Nov;72(5):449-59
references.pmid: 3936330