title: Endocrine disrupting chemicals (EDCs) and female cancer: Informing the patients.
abstract: Breast and uterine cancer are the most frequent female gender related neoplasms whose growth is mostly estrogen dependent. Therefore, any EDC exhibiting estrogenic effects may increase the risk of these two malignancies. This review focuses on the potential role of EDCs with estrogenic potential on the risk of breast and uterine neoplasms but also points to the possible role of the exposure to EDCs in the pathogenesis of ovarian and cervical cancer. It also underlines the necessity of informing the public about the presence of EDCs in common consumer products, their detrimental health effects and methods of reducing the exposure risk.
authors.affiliation: Department of Clinical and Experimental Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211, Gdańsk, Poland. drachon@gumed.edu.pl.
authors.forename: Dominik
authors.initials: D
authors.lastname: Rachoń
mesh_terms: D001943:Breast Neoplasms / Q000139:chemically induced*; D052244:Endocrine Disruptors / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D004967:Estrogens / Q000633:toxicity*; D005260:Female; D005833:Genital Neoplasms, Female / Q000139:chemically induced*; D006801:Humans; D010051:Ovarian Neoplasms / Q000139:chemically induced*
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D004967:Estrogens
keywords: Breast cancer; Cervical cancer; Endocrine disrupting chemicals (EDCs); Female cancer; Ovarian cancer; Uterine cancer
references.citation: Climacteric. 2007 Oct;10(5):416-26
references.pmid: 17852145
references.citation: Bioessays. 2011 May;33(5):332-40
references.pmid: 21503935
references.citation: Horm Metab Res. 2010 Jul;42(8):543-52
references.pmid: 20419622
references.citation: Curr Med Chem. 2014;21(9):1129-45
references.pmid: 24304271
references.citation: Epidemiology. 2015 May;26(3):365-73
references.pmid: 25760782
references.citation: J Clin Endocrinol Metab. 2015 Aug;100(8):2865-72
references.pmid: 26079774
references.citation: Am J Ind Med. 1998 Jul;34(1):6-14
references.pmid: 9617382
references.citation: Rocz Panstw Zakl Hig. 2015;66(1):5-11
references.pmid: 25813067
references.citation: Reprod Toxicol. 2007 Aug-Sep;24(2):139-77
references.pmid: 17825522
references.citation: Reprod Toxicol. 2013 Dec;42:132-55
references.pmid: 23994667
references.citation: J Ark Med Soc. 1979 May;75(12):451-2
references.pmid: 156173
references.citation: Differentiation. 2006 Sep;74(7):365-81
references.pmid: 16916375
references.citation: Sci Total Environ. 2015 Jul 1;520:106-13
references.pmid: 25804877
references.citation: Endocr Relat Cancer. 2015 Apr;22(2):R69-86
references.pmid: 25624167
references.citation: Toxicol Sci. 2003 Sep;75(1):40-6
references.pmid: 12805653
references.citation: BJOG. 2008 Jan;115(2):184-92; discussion 192
references.pmid: 18081600
references.citation: Endocr J. 2004 Dec;51(6):595-600
references.pmid: 15644579
references.citation: Mol Hum Reprod. 2012 Apr;18(4):171-83
references.pmid: 22121209
references.citation: Mol Cell Endocrinol. 2012 Jun 24;357(1-2):101-7
references.pmid: 21945475
references.citation: Environ Health Perspect. 2012 May;120(5):668-73
references.pmid: 22306490
references.citation: Endocr Rev. 2015 Dec;36(6):593-602
references.pmid: 26414233
references.citation: Reprod Toxicol. 2016 Jan;59:167-82
references.pmid: 26493093
references.citation: Reprod Toxicol. 2007 Aug-Sep;24(2):240-52
references.pmid: 17706921
references.citation: Environ Health Perspect. 2011 Sep;119(9):1227-32
references.pmid: 21561829
references.citation: Mech Dev. 1999 Mar;81(1-2):163-7
references.pmid: 10330493
references.citation: Endocrinology. 2006 Jun;147(6 Suppl):S56-69
references.pmid: 16690810
references.citation: Reprod Toxicol. 2007 Aug-Sep;24(2):178-98
references.pmid: 17628395
references.citation: J Natl Cancer Inst. 2003 Aug 20;95(16):1218-26
references.pmid: 12928347
references.citation: Environ Health Perspect. 2011 Dec;119(12):1788-93
references.pmid: 21831745
references.citation: Immunopharmacol Immunotoxicol. 2006;28(3):501-10
references.pmid: 16997798
references.citation: Endocrinology. 1997 May;138(5):1780-6
references.pmid: 9112368
references.citation: Breast Cancer Res Treat. 1998 Jun;49(3):187-93
references.pmid: 9776502
references.citation: Endocrinology. 2005 Feb;146(2):607-12
references.pmid: 15498886
references.citation: Gynecol Oncol. 2015 Jan;136(1):99-103
references.pmid: 25451694
references.citation: Reprod Toxicol. 2015 Jul;54:58-65
references.pmid: 25277313
references.citation: Mutat Res. 1995 Dec;333(1-2):59-67
references.pmid: 8538637
references.citation: Cell. 2011 Mar 4;144(5):646-74
references.pmid: 21376230
references.citation: PLoS One. 2013;8(5):e63902
references.pmid: 23704952
references.citation: Nutr Diabetes. 2014 Jan 13;4:e102
references.pmid: 24418828
references.citation: J Natl Cancer Inst. 2003 Aug 6;95(15):1158-64
references.pmid: 12902445
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14187-91
references.pmid: 18768812
references.citation: Ann Endocrinol (Paris). 2013 Jul;74(3):211-20
references.pmid: 23796010
references.citation: Environ Health Perspect. 2007 Jun;115(6):902-8
references.pmid: 17589598
references.citation: Cancer Causes Control. 1998 Aug;9(4):417-24
references.pmid: 9794174
references.citation: Endocr Rev. 2009 Jun;30(4):293-342
references.pmid: 19502515
references.citation: Mol Carcinog. 2013 Sep;52(9):715-25
references.pmid: 22549810
references.citation: Mol Cell Endocrinol. 2009 May 25;304(1-2):55-62
references.pmid: 19433248
references.citation: N Engl J Med. 2006 Jan 19;354(3):270-82
references.pmid: 16421368
references.citation: Fertil Steril. 2008 Oct;90(4):911-40
references.pmid: 18929049
references.citation: Occup Environ Med. 2002 Sep;59(9):625-8
references.pmid: 12205237
references.citation: Toxicology. 2013 Mar 8;305:41-8
references.pmid: 23328252
references.citation: Med Clin North Am. 2015 May;99(3):469-77
references.pmid: 25841595
references.citation: Environ Res. 2015 Jan;136:381-6
references.pmid: 25460659
references.citation: Hum Reprod. 2004 Jul;19(7):1506-12
references.pmid: 15131079
references.citation: Hum Reprod. 2006 Sep;21(9):2201-8
references.pmid: 16775159
references.citation: J Steroid Biochem Mol Biol. 2015 Sep;153:35-44
references.pmid: 26209254
references.citation: Horm Metab Res. 2007 Apr;39(4):256-61
references.pmid: 17447162
references.citation: Chem Res Toxicol. 2001 Feb;14(2):149-57
references.pmid: 11258963
references.citation: Arch Biochem Biophys. 2015 May 1;573:52-8
references.pmid: 25797437
references.citation: Fertil Steril. 2004 Jul;82(1):145-8, quiz 265
references.pmid: 15237003
references.citation: Maturitas. 2007 Jun 20;57(2):161-70
references.pmid: 17258874
references.citation: J Appl Toxicol. 2012 Jan;32(1):1-9
references.pmid: 22095846
references.citation: Am J Epidemiol. 1997 Aug 15;146(4):294-306
references.pmid: 9270408
references.citation: Arch Toxicol. 2009 Mar;83(3):281-5
references.pmid: 18843480
references.citation: Medicine (Baltimore). 2015 Jan;94(1):e211
references.pmid: 25569640
references.citation: Endocrinology. 2006 Jun;147(6 Suppl):S4-10
references.pmid: 16690812
references.citation: Chemosphere. 2011 Oct;85(6):943-7
references.pmid: 21741673
references.citation: Endokrynol Pol. 2015;66(3):276-81
references.pmid: 26136137
references.citation: Oncologist. 2015 Jan;20(1):45-9
references.pmid: 25410097
references.citation: Environ Health Perspect. 2006 Jun;114(6):898-904
references.pmid: 16759992
references.citation: Mol Cancer Ther. 2002 May;1(7):515-24
references.pmid: 12479269
references.citation: Steroids. 2015 Jul;99(Pt A):8-10
references.pmid: 25555473
references.citation: J Environ Pathol Toxicol. 1979 Dec;3(1-2):191-205
references.pmid: 397957
references.citation: J Ovarian Res. 2014;7:51
references.pmid: 24829615
references.citation: J Reprod Dev. 2009 Feb;55(1):23-9
references.pmid: 18854640
references.citation: Gynecol Endocrinol. 2014 Apr;30(4):260-5
references.pmid: 24397396