title: Characterization of the abnormal lipid profile in Chinese patients with psoriasis.
abstract: Psoriasis is a chronic inflammatory skin disease that has been associated with abnormal lipid metabolism. To characterize the lipid profile in Chinese, 86 patients with psoriasis and 84 healthy control subjects were assessed. Compared with healthy controls, the fasting serum values of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) were lower in the patient group. Compared with vulgaris psoriasis, special types of psoriasis had even lower levels of HDL-C and ApoA-I. Considering the severity of psoriasis, the level of ApoA-I and HDL-C were also the only two serum lipid parameters decreased in the mild group compared to those in controls. In the moderate and the severe group, the values of TC, LDL-C, HDL-C and ApoA-I were all decreased compared to healthy control group. Further analysis indicated that the values of HDL-C and ApoA-I were significantly lower in the severe group compared to the moderate group. Correlation analysis indicated that the levels of HDL-C but not ApoA-I was negatively associated with the severity of the disease. Interestingly, when psoriasis was improved by treatment, the serum levels of TG, TC, HDL-C and ApoA-I were increased from the pre-treatment values. We conclude that abnormalities in serum lipid metabolism may play an important role in the pathogenesis of Chinese patients with psoriasis.
authors.affiliation: Department of Dermatology, Air Force General Hospital, PLA Beijing 100142, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Pang
authors.affiliation: Department of Clinical Laboratory, Air Force General Hospital, PLA Beijing 100142, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Lin
authors.affiliation: Department of Dermatology, Air Force General Hospital, PLA Beijing 100142, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Dermatology, Air Force General Hospital, PLA Beijing 100142, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Statistics, The First Hospital of Peking University Beijing 100030, China.
authors.forename: Sainan
authors.initials: S
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003879:Dermatologic Agents; D008055:Lipids
keywords: Chronic inflammatory skin disease; lipid metabolism; lipid profile; psoriasis
references.citation: J Invest Dermatol. 1958 Apr;30(4):181-5
references.pmid: 13539454
references.citation: J Am Acad Dermatol. 2006 Apr;54(4):614-21
references.pmid: 16546581
references.citation: J Am Acad Dermatol. 2006 Nov;55(5):829-35
references.pmid: 17052489
references.citation: Clin Chem Lab Med. 2002 Jan;40(1):65-8
references.pmid: 11916273
references.citation: Yonsei Med J. 2003 Feb;44(1):24-6
references.pmid: 12619171
references.citation: J Am Acad Dermatol. 2003 Jun;48(6):882-5
references.pmid: 12789179
references.citation: Dermatologica. 1989;179(4):200-1
references.pmid: 2515979
references.citation: Boll Soc Ital Biol Sper. 1992 Dec;68(12):755-9
references.pmid: 1307021
references.citation: Br J Dermatol. 1994 Jun;130(6):738-42
references.pmid: 8011499
references.citation: J Am Acad Dermatol. 1994 Sep;31(3 Pt 1):445-9
references.pmid: 8077470
references.citation: Ir Med J. 1995 Jul-Aug;88(4):128-9
references.pmid: 7672948