title: Long-term evolution and predictive factors of mild inflammatory bowel disease.
abstract: BACKGROUND
  Crohn's disease (CD) and ulcerative colitis (UC) are potentially progressive diseases. Few data are available on the prevalence and the factors associated with mild inflammatory bowel diseases (IBD).
  
  
  OBJECTIVE
  Our aim was to assess the natural history of mild CD and mild UC and to identify predictive factors of mild evolution over the long term.
  
  
  METHODS
  Retrospective study of IBD patients registered in the database of the university hospital CHU of Liège, Belgium. Mild CD was defined as an inflammatory luminal disease (no stricture, abdominal or perianal fistulae) requiring no immunomodulator (IM), anti-TNF and no surgery. Mild UC was defined as no requirement for IM, anti-TNF and no colectomy.
  
  
  RESULTS
  Four hundred and seventy-three CD and 189 UC were included (median follow-up: 13 and 11 years respectively). At 1 year, 147 patients had mild CD. At 5 years and the maximum follow-up, 56% and 13% patients still had mild CD, respectively. At 1 year, 142 patients had mild UC. At 5 years and the maximum follow-up, 72% and 44% still had a mild UC, respectively. Factors associated with long-term mild CD and UC were older age at diagnosis and absence of corticosteroids in the first year. In UC proctitis location was associated with mild UC.
  
  
  CONCLUSIONS
  In this cohort, 90% of CD patients and 3/4 of UC with mild disease at 1 year lost their mild disease status over time. An old age at diagnosis was predictive of the persistence of a mild CD and UC.
authors.affiliation: a Gastroenterology Department , University Hospital of Liège , Liège , Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Reenaers
authors.affiliation: a Gastroenterology Department , University Hospital of Liège , Liège , Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Pirard
authors.affiliation: a Gastroenterology Department , University Hospital of Liège , Liège , Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Vankemseke
authors.affiliation: a Gastroenterology Department , University Hospital of Liège , Liège , Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Latour
authors.affiliation: a Gastroenterology Department , University Hospital of Liège , Liège , Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Belaiche
authors.affiliation: a Gastroenterology Department , University Hospital of Liège , Liège , Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Louis
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000628:therapy; D003424:Crohn Disease / Q000175:diagnosis* / Q000628:therapy; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Benign evolution; complication; mild IBD; predictive factor