title: A twist in zygotic reprogramming.
abstract: The first hours of mammalian embryogenesis are devoted to extensive epigenetic reprogramming. One hallmark is active demethylation of the paternal genome by Tet (ten-eleven translocation) enzymes. However, the process is now shown to be Tet-independent at first, with Tet enzymes only counteracting hitherto underappreciated de novo DNA methylation activity in later zygotic stages.
authors.affiliation: Developmental Epigenetics and Disease Laboratory, Institute of Molecular and Cell Biology, Agency for Science Technology and Research, 61 Biopolis Drive, Singapore 138672.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Messerschmidt
mesh_terms: D044503:5-Methylcytosine / Q000378:metabolism*; D000818:Animals; D065150:Cellular Reprogramming; D003596:Cytosine / Q000031:analogs & derivatives*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D015053:Zygote / Q000378:metabolism*
chemical_list: D044503:5-Methylcytosine; D003596:Cytosine
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