title: Cognitive Stimulation Modulates Platelet Total Phospholipases A2 Activity in Subjects with Mild Cognitive Impairment.
abstract: We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A2 activity (tPLA2A) in patients with mild cognitive impairment (MCI_P). At baseline, tPLA2A negatively correlated with Mini-Mental State Examination score (MMSE_s): patients with MMSE_s <26 (Subgroup 1) had significantly higher activity than those with MMSE_s ≥26 (Subgroup 2), who had values similar to the healthy elderly. Regarding CS effect, Subgroup 1 had a significant tPLA2A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA2A correlates with the cognitive conditions of MCI_P, and that CS acts selectively on subjects with a dysregulated tPLA2A.
authors.affiliation: Center for Neurobiology of Aging, INRCA, Ancona, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Balietti
authors.affiliation: Geriatrics Operative Unit, INRCA, Fermo, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Giuli
authors.affiliation: Center for Neurobiology of Aging, INRCA, Ancona, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Fattoretti
authors.affiliation: Laboratory of Biostatistics, INRCA, Ancona, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fabbietti
authors.affiliation: Geriatrics Operative Unit, INRCA, Fermo, Italy.
authors.forename: Demetrio
authors.initials: D
authors.lastname: Postacchini
authors.affiliation: Center for Neurobiology of Aging, INRCA, Ancona, Italy.|Department of Experimental and Clinical Medicine, Section of Neuroscience and Cell Biology, Università Politecnica delle Marche, Ancona, Italy.
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Conti
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D003071:Cognition / Q000502:physiology; D015928:Cognitive Behavioral Therapy; D060825:Cognitive Dysfunction / Q000097:blood* / Q000628:therapy*; D015331:Cohort Studies; D006801:Humans; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D054467:Phospholipases A2 / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D054467:Phospholipases A2
keywords: Blood platelets; cognitive stimulation; mild cognitive impairment; phospholipases A2
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