title: Dapoxetine and the treatment of premature ejaculation.
abstract: BACKGROUND
  Premature ejaculation (PE) is the most common male sexual complaint. Off-label oral selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for the treatment of PE. Dapoxetine is a short-acting SSRI specifically designed for on-demand use. The objective of this communication is to summarize the clinical and physiological evidence regarding the role of the serotonergic pathway and specifically dapoxetine in the treatment of PE.
  
  
  METHODS
  A PubMed search was conducted on articles reporting data on dapoxetine for the treatment of PE. Articles describing the pathophysiology and treatment options for PE were additionally included for review.
  
  
  RESULTS
  The etiology of PE is multi-factorial in nature. There are many treatment options for PE such as psychological/behavioral therapy, topical anesthetic agents, phosphodiesterase type 5 (PDE-5) inhibitors, and tramadol hydrochloride. SSRIs play a major role in PE treatment. Animal and clinical studies in addition to its pharmacokinetic document dapoxetine's clinical efficacy and safety for on-demand treatment of PE.
  
  
  CONCLUSIONS
  Dapoxetine demonstrates clinical efficacy and a favorable side effect profile. Dapoxetine is currently the oral drug of choice for on-demand treatment of PE.
authors.affiliation: Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA ;
authors.forename: Premsant
authors.initials: P
authors.lastname: Sangkum
authors.affiliation: Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA ;
authors.forename: Rhamee
authors.initials: R
authors.lastname: Badr
authors.affiliation: Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA;; Department of Urology, Bagcilar Training & Research Hospital, Istanbul, Turkey.
authors.forename: Ege Can
authors.initials: EC
authors.lastname: Serefoglu
authors.affiliation: Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA ;
authors.forename: Wayne J G
authors.initials: WJ
authors.lastname: Hellstrom
keywords: Dapoxetine; premature ejaculation (PE); selective serotonin reuptake inhibitor (SSRI)
references.citation: J Urol. 2009 Mar;181(3):1273-80
references.pmid: 19185321
references.citation: J Affect Disord. 2013 Jan 10;144(1-2):7-15
references.pmid: 22963896
references.citation: Urology. 2013 Jan;81(1):98-103
references.pmid: 23102445
references.citation: Eur Urol. 2009 Apr;55(4):967-8
references.pmid: 19195773
references.citation: Core Evid. 2012;7:1-14
references.pmid: 22315582
references.citation: J Sex Med. 2007 Mar;4(2):491-6
references.pmid: 17367444
references.citation: J Urol. 2002 Dec;168(6):2486-9
references.pmid: 12441946
references.citation: Eur Urol. 2007 Mar;51(3):825-32
references.pmid: 17064843
references.citation: Depress Anxiety. 2006;23(3):153-7
references.pmid: 16502416
references.citation: J Clin Psychiatry. 2001;62 Suppl 3:10-21
references.pmid: 11229449
references.citation: J Sex Med. 2007 Sep;4(5):1462-7
references.pmid: 17651386
references.citation: J Sex Med. 2011 Jan;8(1):90-6
references.pmid: 20946168
references.citation: J Clin Pharmacol. 2006 Sep;46(9):1023-9
references.pmid: 16920897
references.citation: Int J Impot Res. 2004 Oct;16(5):427-32
references.pmid: 14973527
references.citation: J Sex Marital Ther. 1989 Summer;15(2):130-4
references.pmid: 2769774
references.citation: Neurosci Lett. 2007 Apr 18;416(3):307-9
references.pmid: 17316999
references.citation: Eur Urol. 2004 Nov;46(5):615-22
references.pmid: 15474272
references.citation: J Urol. 2007 Mar;177(3):1065-70
references.pmid: 17296413
references.citation: Asian J Androl. 2013 Jan;15(1):138-42
references.pmid: 23103596
references.citation: Br J Pharmacol. 1998 Dec;125(8):1733-43
references.pmid: 9886765
references.citation: Int J Androl. 2005 Dec;28 Suppl 2:40-5
references.pmid: 16236063
references.citation: Eur Urol. 2005 Sep;48(3):408-17
references.pmid: 15996810
references.citation: Ann Pharmacother. 2003 Dec;37(12):1804-6
references.pmid: 14632589
references.citation: J Sex Med. 2010 Jun;7(6):2231-42
references.pmid: 20412423
references.citation: J Sex Med. 2010 Mar;7(3):1269-76
references.pmid: 20074312
references.citation: J Sex Med. 2011 Oct;8 Suppl 4:316-27
references.pmid: 21967394
references.citation: Eur Urol. 2004 Oct;46(4):510-5; discussion 516
references.pmid: 15363569
references.citation: Pharmacopsychiatry. 2010 Jun;43(4):156-7
references.pmid: 20309810
references.citation: Curr Urol Rep. 2006 Nov;7(6):479-84
references.pmid: 17052445
references.citation: Eur J Pharmacol. 1993 Oct 26;243(3):227-34
references.pmid: 8276074
references.citation: Eur J Neurosci. 2005 Aug;22(3):724-34
references.pmid: 16101754
references.citation: Am J Psychiatry. 1994 Sep;151(9):1377-9
references.pmid: 8067497
references.citation: J Sex Med. 2006 Jul;3(4):682-92
references.pmid: 16839325
references.citation: Anat Embryol (Berl). 1981;161(4):355-71
references.pmid: 7247034
references.citation: Int J Impot Res. 2006 Jan-Feb;18(1):104-10
references.pmid: 16307008
references.citation: Neuroreport. 1998 Jan 26;9(2):341-5
references.pmid: 9507980
references.citation: J Sex Med. 2011 Feb;8(2):524-39
references.pmid: 21059176
references.citation: J Sex Med. 2005 May;2(3):368-75
references.pmid: 16422868
references.citation: Urology. 2001 Aug;58(2):198-202
references.pmid: 11489699
references.citation: J Sex Marital Ther. 2006 Mar-Apr;32(2):97-114
references.pmid: 16418103
references.citation: J Androl. 2006 Jan-Feb;27(1):86-93
references.pmid: 16400083
references.citation: Adv Psychosom Med. 2008;29:50-69
references.pmid: 18391557
references.citation: J Sex Med. 2011 Oct;8 Suppl 4:335-41
references.pmid: 21967395
references.citation: South Med J. 1956 Apr;49(4):353-8
references.pmid: 13311629
references.citation: Behav Brain Res. 1998 May;92(2):111-8
references.pmid: 9638953
references.citation: J Urol. 1998 Jun;159(6):1935-8
references.pmid: 9598491
references.citation: Eur Urol. 2014 Apr;65(4):733-9
references.pmid: 23993257
references.citation: J Clin Pharmacol. 2006 Mar;46(3):301-9
references.pmid: 16490806
references.citation: Pharmacol Ther. 2000 Jan;85(1):11-28
references.pmid: 10674711
references.citation: Arch Sex Behav. 1985 Dec;14(6):467-89
references.pmid: 4084048
references.citation: Eur Urol. 2006 Sep;50(3):454-66
references.pmid: 16844284
references.citation: Eur Urol. 2012 Apr;61(4):736-43
references.pmid: 21889833
references.citation: BJU Int. 2006 Aug;98(2):259-72
references.pmid: 16879663
references.citation: Int Clin Psychopharmacol. 1998 Jul;13 Suppl 6:S9-14
references.pmid: 9728669
references.citation: J Sex Med. 2013 Jan;10(1):204-29
references.pmid: 22970767
references.citation: Int J Impot Res. 2002 Dec;14(6):502-5
references.pmid: 12494286
references.citation: J Sex Med. 2012 Oct;9(10):2562-73
references.pmid: 22906232
references.citation: Curr Opin Urol. 2005 Nov;15(6):399-403
references.pmid: 16205491
references.citation: Expert Opin Drug Deliv. 2008 Feb;5(2):251-61
references.pmid: 18248322
references.citation: Urol Clin North Am. 2007 Nov;34(4):591-9, vii-viii
references.pmid: 17983899
references.citation: Neuropsychiatr Dis Treat. 2009;5:37-46
references.pmid: 19557098
references.citation: Int J Psychiatry Clin Pract. 1998;2(4):287-93
references.pmid: 24927094
references.citation: Eur Urol. 2012 Apr;61(4):744-5
references.pmid: 21978420
references.citation: J Urol. 1995 Oct;154(4):1360-1
references.pmid: 7658537
references.citation: Eur Urol. 2009 Apr;55(4):957-67
references.pmid: 19195772
references.citation: Lancet. 2006 Sep 9;368(9539):929-37
references.pmid: 16962882
references.citation: J Urol. 2007 Jan;177(1):386-9
references.pmid: 17162096
references.citation: Int J Clin Pract. 2011 Jan;65(1):16-26
references.pmid: 21155940
references.citation: J Sex Med. 2010 Sep;7(9):2947-69
references.pmid: 21050394
references.citation: J Sex Med. 2008 Jul;5(7):1590-606
references.pmid: 18466262
references.citation: Pharmacol Toxicol. 1996 Apr;78(4):203-8
references.pmid: 8861776
references.citation: Arch Ital Urol Androl. 2007 Jun;79(2):67-70
references.pmid: 17695411
references.citation: J Clin Psychiatry. 1995 Sep;56(9):402-7
references.pmid: 7665538
references.citation: BJU Int. 2008 Sep;102(6):668-75
references.pmid: 18485043
references.citation: J Sex Med. 2013 Sep;10(9):2312-25
references.pmid: 23845016
references.citation: Urol Int. 2008;80(2):162-5
references.pmid: 18362486
references.citation: J Sex Med. 2006 Nov;3(6):1004-12
references.pmid: 17100933
references.citation: J Sex Med. 2010 Apr;7(4 Pt 2):1668-86
references.pmid: 20388164
references.citation: Clin Pharmacol Ther. 2011 Jan;89(1):125-8
references.pmid: 21085116
references.citation: Int J Impot Res. 2009 Jul-Aug;21(4):221-7
references.pmid: 19474796
references.citation: Arch Sex Behav. 1995 Aug;24(4):447-72
references.pmid: 7661658
references.citation: J Int Med Res. 1980;8 Suppl 3:53-9
references.pmid: 7193614
references.citation: J Sex Marital Ther. 1997 Fall;23(3):176-94
references.pmid: 9292833
references.citation: J Urol. 1996 Nov;156(5):1631-2
references.pmid: 8863556
references.citation: J Sex Marital Ther. 1997 Spring;23(1):3-23
references.pmid: 9094032
references.citation: BJU Int. 2009 Mar;103(5):651-8
references.pmid: 19021601
references.citation: Am J Addict. 2006 Jan-Feb;15(1):100-4
references.pmid: 16449099
references.citation: J Sex Med. 2012 Sep;9(9):2404-16
references.pmid: 22248110
references.citation: BJU Int. 2004 May;93(7):1018-21
references.pmid: 15142155
references.citation: J Sex Med. 2010 Jan;7(1 Pt 1):256-68
references.pmid: 19878447
references.citation: Urol Int. 2013;91(2):197-205
references.pmid: 23751284
references.citation: Int J Impot Res. 2004 Aug;16(4):369-81
references.pmid: 14961051
references.citation: Pharmacol Biochem Behav. 1976 Mar;4(3):357-9
references.pmid: 132671
references.citation: J Sex Med. 2010 Apr;7(4 Pt 1):1381-90
references.pmid: 20141582
references.citation: Urology. 2013 Sep;82(3):620-4
references.pmid: 23987156
references.citation: Urology. 2012 Sep;80(3):618-24
references.pmid: 22840860
references.citation: J Urol. 2002 Dec;168(6):2359-67
references.pmid: 12441918