title: Is Aerosolized Pentamidine for Pneumocystis Pneumonia Prophylaxis in Renal Transplant Recipients Not as Safe as We Might Think?
abstract: Outbreaks ofPneumocystispneumonia have been described in renal transplant recipients. Aerosolized pentamidine is frequently used for prophylaxis in this setting. We report our experience with aerosolized pentamidine use in 56 renal transplant recipients. We found high rates of adverse reactions in patients with chronic respiratory disease.
authors.affiliation: Department of Infectious Diseases, Austin Health, Melbourne, Australia Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA nenad.macesic@austin.org.au lindsay.grayson@austin.org.au.
authors.forename: N
authors.initials: N
authors.lastname: Macesic
authors.affiliation: Department of Infectious Diseases, Austin Health, Melbourne, Australia.
authors.forename: K
authors.initials: K
authors.lastname: Urbancic
authors.affiliation: Department of Nephrology, Austin Health, Melbourne, Australia Department of Medicine, University of Melbourne, Melbourne, Australia.
authors.forename: F
authors.initials: F
authors.lastname: Ierino
authors.affiliation: Department of Infectious Diseases, Austin Health, Melbourne, Australia Department of Medicine, University of Melbourne, Melbourne, Australia nenad.macesic@austin.org.au lindsay.grayson@austin.org.au.
authors.forename: M L
authors.initials: ML
authors.lastname: Grayson
mesh_terms: D000328:Adult; D000336:Aerosols; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001986:Bronchial Spasm / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010419:Pentamidine / Q000008:administration & dosage / Q000009:adverse effects*; D011010:Pneumocystis / Q000187:drug effects / Q000502:physiology; D011020:Pneumonia, Pneumocystis / Q000382:microbiology / Q000517:prevention & control*; D051436:Renal Insufficiency, Chronic / Q000473:pathology / Q000601:surgery; D012140:Respiratory Tract Diseases / Q000503:physiopathology*; D066027:Transplant Recipients; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D000336:Aerosols; D000935:Antifungal Agents; D010419:Pentamidine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
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