title: Antidiabetic and hypolipidemic effects of adropinin streoptozotocin-induced type 2 diabetic rats.
abstract: BACKGROUND
  To examine the effects of adropin on glucose and lipid metabolism in a rat model of Type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  T2DM were established using high-fat diet and streptozocin (STZ; 35 mg/kg/b.w.). Seven days after STZ induction, diabetic rats were randomly treated with adropin (2.1 μg/kg/day intraperitonealy) for 10 days. The study involved the evaluation of biochemical parameters, including blood glucose, total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) activities. Additionally, Tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and inducible nitric oxide synthase (iNOS) mRNA gene expressions in pancreas tissue were determined by reverse transcription-polymerase chain reaction.
  
  
  RESULTS
  The serum levels of insulin and adropin were determined by ELISA. Treatment with adropin showed a significant reduction in blood glucose levels, HbA1c (%), HOMA-IR and increase in HOMA-β, serum insulin levels. In addition, intraperitoneal adropin application can reduce serum levels of TC, TG, LDL-C, and increase level of HDL-C. Adropin also effectively ameliorated the alterations in TNF-α, IL-6 and iNOS mRNA expression.
  
  
  CONCLUSIONS
  The present study indicates that the adropin possesses antidiabetic and antidyslipidemic effects in T2DM (Tab. 2, Fig. 3, Ref. 32).
authors.forename: R
authors.initials: R
authors.lastname: Akcilar
authors.forename: F E
authors.initials: FE
authors.lastname: Kocak
authors.forename: H
authors.initials: H
authors.lastname: Simsek
authors.forename: A
authors.initials: A
authors.lastname: Akcilar
authors.forename: Z
authors.initials: Z
authors.lastname: Bayat
authors.forename: E
authors.initials: E
authors.lastname: Ece
authors.forename: H
authors.initials: H
authors.lastname: Kokdasgil
mesh_terms: D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000097:blood / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000097:blood / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D010179:Pancreas / Q000473:pathology; D010455:Peptides / Q000097:blood / Q000494:pharmacology; D051381:Rats; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; C586182:ENHO protein, rat; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D008074:Lipoproteins; D010455:Peptides; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: adropin; blood glucose; high fat diet.; insulin; type 2 diabetic rat