title: Immunohistochemical Evaluation of Glucose Transporter Type 1 in Epithelial Dysplasia and Oral Squamous Cell Carcinoma.
abstract: Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and some of these have been documented in association or preceded by oral epithelial dysplasia (OED). Aggressive cancers with fast growth have demonstrated overexpression of some glucose transporters (GLUTs). Thus, the aim of this study was to analyze the immunohistochemical expression of the glucose transporter, GLUT-1, in OEDs and OSCCs, seeking to better elucidate the biological behavior of neoplasias. Fifteen cases were selected this research of both lesions. Five areas were analyzed from each case by counting the percentage of positive cells at 400x magnification. Immunoreactivity of GLUT-1 was observed in 100% of the samples ranging from 54.2% to 86.2% for the OSCC and 73.9% to 97.4% for the OED. Statistical test revealed that there was greater overexpression of GLUT-1 in OED than the OSCC (p=0.01). It is believed the high expression of GLUT-1 may reflect the involvement of GLUT-1 in early stages of oral carcinogenesis.
authors.affiliation: Department of Oral Pathology, School of Dentistry, Federal University of Ceara - Campus Sobral, Sobral, Brazil E-mail : fwildson@yahoo.com.br.
authors.forename: Karuza Maria Alves
authors.initials: KM
authors.lastname: Pereira
authors.forename: Sthefane Gomes
authors.initials: SG
authors.lastname: Feitosa
authors.forename: Ana Thayssa Tomaz
authors.initials: AT
authors.lastname: Lima
authors.forename: Ealber Carvalho Macedo
authors.initials: EC
authors.lastname: Luna
authors.forename: Roberta Barroso
authors.initials: RB
authors.lastname: Cavalcante
authors.forename: Kenio Costa
authors.initials: KC
authors.lastname: de Lima
authors.forename: Filipe Nobre
authors.initials: FN
authors.lastname: Chaves
authors.forename: Fábio Wildson Gurgel
authors.initials: FW
authors.lastname: Costa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000378:metabolism / Q000473:pathology; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011230:Precancerous Conditions / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D051272:Glucose Transporter Type 1