title: Association Between Leptin (-2548G/A) Genes Polymorphism and Breast Cancer Susceptibility: A Meta-Analysis.
abstract: Leptin is a confirmed breast cancer susceptibility gene. However, published studies reported mixed results. This meta-analysis was conducted to systematically get a more accurate estimation of the association between the Leptin (-2548G/A) gene polymorphism and breast cancer risk. To assess the effect of Leptin (-2548G/A) gene polymorphism on breast cancer susceptibility, we searched PUBMED, ISI Web of Knowledge, EMBASE, Chinese National Knowledge Infrastructure (CNKI) databases until September 2015 to identify eligible studies, without restriction. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to breast cancer. Separate analyses were conducted on features of the population such as ethnicity, source of controls, and country. A total of 9 case-control studies on Leptin (-2548G/A) gene polymorphism and breast cancer risk, including 3725 cases and 3093 case-free controls were identified. The results revealed that compared with the G allele, the A allele was associated with modestly increased risk of overall breast cancer (A vs G: OR = 1.12, 95%CI = 1.04-1.20, P = 0.002, Phet P < 0.00001). Following further stratified analyses, in the subgroup analyses by ethnicity, a significantly increased risk was observed among Caucasian (A vs G: OR = 1.11, 95%CI = 1.03-1.20, P = 0.006, Phet = 0.00001). No publication bias was found in the present study. In conclusion, our meta-analysis suggests that the Leptin (-2548G/A) gene polymorphism plays an important role in breast cancer susceptibility, especially in Caucasian.
authors.affiliation: From the Department of Oncology, the Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.
authors.forename: Wanjun
authors.initials: W
authors.lastname: Yan
authors.forename: Xingcong
authors.initials: X
authors.lastname: Ma
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Gao
authors.forename: Shuqun
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020738:Leptin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics*
chemical_list: D020738:Leptin
references.citation: Physiol Res. 2006;55(3):233-44
references.pmid: 16238454
references.citation: Cancer Causes Control. 1998 Mar;9(2):217-24
references.pmid: 9578299
references.citation: Diabetes. 1998 Mar;47(3):487-9
references.pmid: 9519759
references.citation: Nature. 1994 Dec 1;372(6505):425-32
references.pmid: 7984236
references.citation: Ann N Y Acad Sci. 2007 Jan;1095:90-8
references.pmid: 17404022
references.citation: Int J Cancer. 2006 Mar 15;118(6):1414-9
references.pmid: 16206269
references.citation: Breast Cancer Res. 2005;7(5):R627-33
references.pmid: 16168107
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2553-7
references.pmid: 19723917
references.citation: Clin Cancer Res. 2004 Jul 1;10(13):4325-31
references.pmid: 15240518
references.citation: Eur J Endocrinol. 2000 Sep;143(3):293-311
references.pmid: 11022169
references.citation: Int J Clin Exp Med. 2015 Jan 15;8(1):448-55
references.pmid: 25785016
references.citation: Mol Cell Endocrinol. 2002 Feb 25;188(1-2):219-26
references.pmid: 11911959
references.citation: J Cancer Res Clin Oncol. 2009 Apr;135(4):603-12
references.pmid: 18855010
references.citation: Cancer Biol Ther. 2015;16(8):1220-30
references.pmid: 26121010
references.citation: Proc Soc Exp Biol Med. 1997 Oct;216(1):28-43
references.pmid: 9316608
references.citation: Prostate. 2004 May 15;59(3):268-74
references.pmid: 15042602
references.citation: Int J Cancer. 2009 Sep 1;125(5):1038-44
references.pmid: 19408304
references.citation: Iran J Cancer Prev. 2015 Mar-Apr;8(2):100-8
references.pmid: 25960849
references.citation: Int J Genomics. 2015;2015:132720
references.pmid: 26199932
references.citation: Science. 1995 Jul 28;269(5223):543-6
references.pmid: 7624777
references.citation: Maturitas. 2001 Feb 28;38(1):103-13; discussion 113-6
references.pmid: 11311599
references.citation: Int J Oncol. 2004 Jun;24(6):1529-35
references.pmid: 15138597
references.citation: J Korean Surg Soc. 2012 Jul;83(1):7-13
references.pmid: 22792528
references.citation: Eur J Cancer. 2006 May;42(8):1188-93
references.pmid: 16630717
references.citation: J Biol Chem. 2003 Aug 1;278(31):28668-76
references.pmid: 12734209
references.citation: N Engl J Med. 2000 Jul 13;343(2):78-85
references.pmid: 10891514
references.citation: Int J Cancer. 2008 Apr 1;122(7):1611-7
references.pmid: 18059035
references.citation: Endocrine. 2005 Feb;26(1):19-24
references.pmid: 15805581
references.citation: Clin Cancer Res. 2006 Mar 1;12(5):1447-53
references.pmid: 16533767
references.citation: J Natl Cancer Inst. 2002 Nov 20;94(22):1704-11
references.pmid: 12441326
references.citation: J Nutr. 1997 May;127(5 Suppl):921S-923S
references.pmid: 9164264
references.citation: Life Sci. 2015 Nov 1;140:37-48
references.pmid: 25957709
references.citation: Nat Med. 1995 Dec;1(12):1311-4
references.pmid: 7489415
references.citation: Klin Onkol. 2009;22(5):223-7
references.pmid: 19886360
references.citation: Mol Biol Rep. 2012 Apr;39(4):3471-7
references.pmid: 21725850
references.citation: PLoS One. 2013 Jun 27;8(6):e67349
references.pmid: 23826274
references.citation: Pharmacogenomics. 2008 Dec;9(12):1879-902
references.pmid: 19072646
references.citation: Breast Cancer Res Treat. 2010 Apr;120(3):745-52
references.pmid: 19697123
references.citation: Nutr Cancer. 2014;66(4):645-55
references.pmid: 24738610
references.citation: CA Cancer J Clin. 2013 Jan;63(1):11-30
references.pmid: 23335087
references.citation: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Dec;29(12):1272-6
references.pmid: 24321071
references.citation: BMC Cancer. 2006 Feb 20;6:38
references.pmid: 16504019
references.citation: Science. 1995 Jul 28;269(5223):546-9
references.pmid: 7624778
references.citation: Gene. 2015 Feb 25;557(2):154-7
references.pmid: 25510398