title: Design of Xylose-Based Semisynthetic Polyurethane Tissue Adhesives with Enhanced Bioactivity Properties.
abstract: Developing biocompatible tissue adhesives with high adhesion properties is a highly desired goal of the tissue engineering due to adverse effects of the sutures. Therefore, our work involves synthesis, characterization, adhesion properties, protein adsorption, in vitro biodegradation, in vitro and in vivo biocompatibility properties of xylose-based semisynthetic polyurethane (NPU-PEG-X) bioadhesives. Xylose-based semisynthetic polyurethanes were developed by the reaction among 4,4'-methylenebis(cyclohexyl isocyanate) (MCI), xylose and polyethylene glycol 200 (PEG). Synthesized polyurethanes (PUs) showed good thermal stability and high adhesion strength. The highest values in adhesion strength were measured as 415.0 ± 48.8 and 94.0 ± 2.8 kPa for aluminum substrate and muscle tissue in 15% xylose containing PUs (NPU-PEG-X-15%), respectively. The biodegradation of NPU-PEG-X-15% was also determined as 19.96 ± 1.04% after 8 weeks of incubation. Relative cell viability of xylose containing PU was above 86%. Moreover, 10% xylose containing NPU-PEG-X (NPU-PEG-X-10%) sample has favorable tissue response, and inflammatory reaction between 1 and 6 weeks implantation period. With high adhesiveness and biocompatibility properties, NPU-PEG-X can be used in the medical field as supporting materials for preventing the fluid leakage after abdominal surgery or wound closure.
authors.affiliation: Department of Chemistry, Faculty of Science, Inonu University , Malatya 44280, Turkey.
authors.forename: Sevgi
authors.initials: S
authors.lastname: Balcioglu
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Inonu University , Malatya 44280, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Parlakpinar
authors.affiliation: Department of Histology-Embryology, Faculty of Medicine, Inonu University , Malatya 44280, Turkey.
authors.forename: Nigar
authors.initials: N
authors.lastname: Vardi
authors.affiliation: Department of Chemistry, Faculty of Science, Hacettepe University , Ankara 06800, Turkey.
authors.forename: Emir Baki
authors.initials: EB
authors.lastname: Denkbas
authors.affiliation: Department of Chemistry, Faculty of Science, Inonu University , Malatya 44280, Turkey.
authors.forename: Merve Goksin
authors.initials: MG
authors.lastname: Karaaslan
authors.affiliation: Department of Chemistry, Faculty of Science, Inonu University , Malatya 44280, Turkey.
authors.forename: Selam
authors.initials: S
authors.lastname: Gulgen
authors.affiliation: Department of Histology-Embryology, Faculty of Medicine, Inonu University , Malatya 44280, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Taslidere
authors.affiliation: Department of Chemistry, Faculty of Science, Inonu University , Malatya 44280, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Koytepe
authors.affiliation: Department of Chemistry, Faculty of Science, Inonu University , Malatya 44280, Turkey.
authors.forename: Burhan
authors.initials: B
authors.lastname: Ates
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D018625:Microscopy, Atomic Force; D011092:Polyethylene Glycols / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry / Q000627:therapeutic use; D013499:Surface Properties; D014014:Tissue Adhesives / Q000737:chemistry* / Q000627:therapeutic use; D023822:Tissue Engineering; D014994:Xylose / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D001672:Biocompatible Materials; D011140:Polyurethanes; D014014:Tissue Adhesives; D011092:Polyethylene Glycols; D014994:Xylose
keywords: biocompatibility; polyurethane; semisynthetic materials; tissue adhesive; xylose