title: Speed of sound in diseased liver observed by scanning acoustic microscopy with 80 MHz and 250 MHz.
abstract: In this study, the speed of sound (SOS) of two types of rat livers (eight normal livers, four cirrhotic livers) was measured with a scanning acoustic microscope using two transducers, one of which had an 80-MHz and the other a 250-MHz center frequency. The 250-MHz transducer had a better spatial resolution adapted to studying fiber or hepatic parenchymal cells. In normal livers, averages of the SOS values were from 1598 to 1677 m/s at 80-MHz and from 1568 to 1668 m/s at 250-MHz. In the fiber tissue of cirrhotic livers, averages of the SOS values were from 1645 to 1658 m/s at 80-MHz and from 1610 to 1695 m/s at 250-MHz, while the SOS values in the other tissue of cirrhotic livers ranged from 1644 to 1709 m/s at 80-MHz and from 1641 to 1715 m/s at 250-MHz. In one liver, SOS in fiber tissue was larger than that of tissues without fiber while in others it was lower. The resulting two-dimensional SOS maps provide a unique quantitative insight of liver acoustic microstructures in a healthy liver and in a cirrhotic ones. This study would be helpful to understand the complex relationship between acoustic properties and liver disease including fiber tissue.
authors.affiliation: Graduate School of Engineering, Chiba University, 1-33 Yayoicho, Inage, Chiba, Japan.
authors.forename: So
authors.initials: S
authors.lastname: Irie
authors.affiliation: Graduate School of Engineering, Chiba University, 1-33 Yayoicho, Inage, Chiba, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Center for Frontier Medical Engineering, Chiba University, 1-33 Yayoicho, Inage, Chiba, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Lizzi Center for Biomedical Engineering, Riverside Research, 156 William Street, New York, New York 10038, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mamou
authors.affiliation: Honda Electronics Co., Ltd., 20 Koyamazuka, Oiwa-cho, Toyohashi, Japan.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Kobayashi
authors.affiliation: Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo, Chiba, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Maruyama
authors.affiliation: Center for Frontier Medical Engineering, Chiba University, 1-33 Yayoicho, Inage, Chiba, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D004867:Equipment Design; D008099:Liver / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D033401:Microscopy, Acoustic / Q000295:instrumentation / Q000379:methods; D051381:Rats; D013016:Sound; D013018:Sound Spectrography