title: Touch and go: nuclear proteolysis in the regulation of metabolic genes and cancer.
abstract: The recruitment of transcription factors to promoters and enhancers is a critical step in gene regulation. Many of these proteins are quickly removed from DNA after they completed their function. Metabolic genes in particular are dynamically regulated and continuously adjusted to cellular requirements. Transcription factors controlling metabolism are therefore under constant surveillance by the ubiquitin-proteasome system, which can degrade DNA-bound proteins in a site-specific manner. Several of these metabolic transcription factors are critical to cancer cells, as they promote uncontrolled growth and proliferation. This review highlights recent findings in the emerging field of nuclear proteolysis and outlines novel paradigms for cancer treatment, with an emphasis on multiple myeloma.
authors.affiliation: Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.|Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Laure
authors.initials: L
authors.lastname: Maneix
authors.affiliation: Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.|Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.|Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA.|Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: André
authors.initials: A
authors.lastname: Catic
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002467:Cell Nucleus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008954:Models, Biological; D009101:Multiple Myeloma / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011480:Protease Inhibitors / Q000627:therapeutic use; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D055550:Protein Stability / Q000187:drug effects; D059748:Proteolysis / Q000187:drug effects; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011480:Protease Inhibitors; D014157:Transcription Factors; D043743:Ubiquitin-Protein Ligase Complexes; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex
keywords: genome regulation; mitochondria; multiple myeloma; nuclear proteostasis; nuclear receptor corepressor 1; ubiquitin-proteasome system
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