title: Short separation regression improves statistical significance and better localizes the hemodynamic response obtained by near-infrared spectroscopy for tasks with differing autonomic responses.
abstract: Autonomic nervous system response is known to be highly task-dependent. The sensitivity of near-infrared spectroscopy (NIRS) measurements to superficial layers, particularly to the scalp, makes it highly susceptible to systemic physiological changes. Thus, one critical step in NIRS data processing is to remove the contribution of superficial layers to the NIRS signal and to obtain the actual brain response. This can be achieved using short separation channels that are sensitive only to the hemodynamics in the scalp. We investigated the contribution of hemodynamic fluctuations due to autonomous nervous system activation during various tasks. Our results provide clear demonstrations of the critical role of using short separation channels in NIRS measurements to disentangle differing autonomic responses from the brain activation signal of interest.
authors.affiliation: Massachusetts General Hospital , Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, United States.
authors.forename: Meryem A
authors.initials: MA
authors.lastname: Yücel
authors.affiliation: Massachusetts General Hospital , Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, United States.
authors.forename: Juliette
authors.initials: J
authors.lastname: Selb
authors.affiliation: Boston Children's Hospital , Center for Pain and the Brain, Departments of Anaesthesia and Radiology, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Aasted
authors.affiliation: Boston Children's Hospital , Center for Pain and the Brain, Departments of Anaesthesia and Radiology, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
authors.forename: Mike P
authors.initials: MP
authors.lastname: Petkov
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, United States; Boston Children's Hospital, Center for Pain and the Brain, Departments of Anaesthesia and Radiology, 300 Longwood Avenue, Boston, Massachusetts 02115, United States; Harvard Medical School, Department of Anesthesiology, Perioperative, and Pain Medicine, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
authors.forename: Lino
authors.initials: L
authors.lastname: Becerra
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, United States; Boston Children's Hospital, Center for Pain and the Brain, Departments of Anaesthesia and Radiology, 300 Longwood Avenue, Boston, Massachusetts 02115, United States; Harvard Medical School, Department of Anesthesiology, Perioperative, and Pain Medicine, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
authors.forename: David
authors.initials: D
authors.lastname: Borsook
authors.affiliation: Massachusetts General Hospital , Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, United States.
authors.forename: David A
authors.initials: DA
authors.lastname: Boas
keywords: autonomic nervous system; electrical stimulus; finger tapping; functional near-infrared spectroscopy; pain; systemic physiology
references.citation: Psychophysiology. 1999 Jul;36(4):453-63
references.pmid: 10432794
references.citation: J Biomed Opt. 2009 Nov-Dec;14(6):064025
references.pmid: 20059263
references.citation: Phys Med Biol. 1988 Dec;33(12):1433-42
references.pmid: 3237772
references.citation: Neuroimage. 2003 Sep;20(1):479-88
references.pmid: 14527608
references.citation: J Biomed Opt. 2009 Nov-Dec;14(6):064034
references.pmid: 20059272
references.citation: Med Biol Eng Comput. 1988 May;26(3):289-94
references.pmid: 2855531
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:279-86
references.pmid: 23370052
references.citation: Opt Express. 2008 Jan 21;16(2):1029-50
references.pmid: 18542176
references.citation: Circ Res. 1987 Mar;60(3):309-26
references.pmid: 2438066
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:547-54
references.pmid: 23684871
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:363-71
references.pmid: 23648964
references.citation: Sci Rep. 2015 Mar 30;5:9469
references.pmid: 25820289
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:272-8
references.pmid: 23631984
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:400-7
references.pmid: 23721726
references.citation: Psychophysiology. 1986 Jan;23(1):1-14
references.pmid: 3511488
references.citation: Neurosci Lett. 1993 May 14;154(1-2):101-4
references.pmid: 8361619
references.citation: Neuroimage. 2012 May 15;61(1):70-81
references.pmid: 22426347
references.citation: J Biomed Opt. 2005 Jan-Feb;10(1):11014
references.pmid: 15847580
references.citation: Neurophotonics. 2015 Apr;2(2):020801
references.pmid: 26157991
references.citation: Lasers Med Sci. 2010 May;25(3):431-8
references.pmid: 20143117
references.citation: J Biomed Opt. 2007 Nov-Dec;12(6):064009
references.pmid: 18163825
references.citation: Med Phys. 2000 Apr;27(4):801-15
references.pmid: 10798703
references.citation: Pain Res Manag. 2014 May-Jun;19(3):159-67
references.pmid: 24533429
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:498-507
references.pmid: 23764293
references.citation: Adv Exp Med Biol. 2010;662:237-43
references.pmid: 20204798
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:626-36
references.pmid: 23850462
references.citation: Neuroimage. 2000 Dec;12(6):623-39
references.pmid: 11112395
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:326-34
references.pmid: 23624495
references.citation: Am J Pharm Educ. 2007 Aug 15;71(4):78
references.pmid: 17786266
references.citation: Neuroimage. 2011 Jun 1;56(3):1362-71
references.pmid: 21385616
references.citation: Psychophysiology. 1983 Nov;20(6):611-24
references.pmid: 6657849
references.citation: Neuroimage. 2004;23 Suppl 1:S275-88
references.pmid: 15501097
references.citation: Neuroimage. 2011 Aug 1;57(3):991-1002
references.pmid: 21600294
references.citation: Psychophysiology. 2003 Jul;40(4):548-60
references.pmid: 14570163
references.citation: J Biomed Opt. 2007 Jul-Aug;12(4):044014
references.pmid: 17867818
references.citation: Hum Brain Mapp. 1998;6(3):150-9
references.pmid: 9673670
references.citation: Appl Opt. 2009 Apr 1;48(10):D280-98
references.pmid: 19340120
references.citation: Science. 1977 Dec 23;198(4323):1264-7
references.pmid: 929199
references.citation: J Biomed Opt. 2008 May-Jun;13(3):034017
references.pmid: 18601562
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:592-607
references.pmid: 23664952
references.citation: Front Neuroenergetics. 2010 Jul 14;2:null
references.pmid: 20725524
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:264-71
references.pmid: 24128733
references.citation: Adv Physiol Educ. 2011 Mar;35(1):28-32
references.pmid: 21385998
references.citation: Psychophysiology. 1995 May;32(3):292-9
references.pmid: 7784538