title: Clinical significance of different virus load of human bocavirus in patients with lower respiratory tract infection.
abstract: To assess the impact of human bocavirus (HBoV) virus load on epidemiologic and clinical characteristics in children with lower respiratory tract infection (LRTI). Clinical records of a total of 654 patients with HBoV infection during January 2013 and December 2014 were retrospectively reviewed. Patients with high HBoV virus load infection had a similar age distribution with the total HBoV infection, which had a peak age group of 6-24 months. Patients with high virus load are significantly younger (P < 0.01) than those with low load. The patients who had wheeze and tachypnea/dyspnea at presentation were more strongly affiliated with the patients with high virus load (both P < 0.01). Co-infection was found significantly more frequently among patients with low virus load than those with high virus load (57.0% vs 38.9%; P < 0.01). High virus load was a significant predictor of severe LRTI (P < 0.05). HBoV infections are found in an important proportion of the hospitalized children with respiratory illnesses (8.85% in our series). A high HBoV virus load could be an etiologic agent for LRTI, which may lead to more severe lower respiratory tract symptom and severe disease.
authors.affiliation: Department of Respiratory Medicine, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Wujun
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Pediatrics, People's Hospital of Weifang, Weifang, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yin
authors.affiliation: Department of Infectious Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Weifang
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Yongdong
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Respiratory Medicine, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ji
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D060085:Coinfection; D004279:DNA, Viral; D005260:Female; D056661:Human bocavirus / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009305:Nasopharynx / Q000821:virology; D010322:Parvoviridae Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology*; D016133:Polymerase Chain Reaction; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology*; D012307:Risk Factors; D012621:Seasons; D012720:Severity of Illness Index; D019562:Viral Load
chemical_list: D004279:DNA, Viral
references.citation: BMC Infect Dis. 2011;11:345
references.pmid: 22168387
references.citation: J Clin Virol. 2010 Nov;49(3):158-62
references.pmid: 20833582
references.citation: Paediatr Respir Rev. 2013 Mar;14(1):38-45
references.pmid: 23347659
references.citation: J Infect Dis. 2013 Mar 15;207(6):982-9
references.pmid: 23288925
references.citation: Clin Infect Dis. 2015 Jan 1;60(1):1-9
references.pmid: 25205769
references.citation: Clin Infect Dis. 2015 Oct 15;61(8):1225-7
references.pmid: 26245664
references.citation: Clin Infect Dis. 2015 Oct 15;61(8):1217-24
references.pmid: 26245665
references.citation: Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12891-6
references.pmid: 16118271
references.citation: J Clin Microbiol. 2006 Mar;44(3):1132-4
references.pmid: 16517912
references.citation: Emerg Infect Dis. 2006 May;12(5):848-50
references.pmid: 16704852
references.citation: Clin Infect Dis. 2006 Sep 1;43(5):585-92
references.pmid: 16886150
references.citation: BMC Infect Dis. 2006;6:109
references.pmid: 16834781
references.citation: Emerg Infect Dis. 2006 Aug;12(8):1254-6
references.pmid: 16965708
references.citation: J Clin Microbiol. 2007 Feb;45(2):610-3
references.pmid: 17122013
references.citation: Clin Infect Dis. 2007 Apr 1;44(7):904-10
references.pmid: 17342639
references.citation: J Med Virol. 2007 May;79(5):539-43
references.pmid: 17385723
references.citation: Emerg Infect Dis. 2008 Feb;14(2):217-21
references.pmid: 18258113
references.citation: Clin Microbiol Rev. 2008 Apr;21(2):291-304, table of contents
references.pmid: 18400798
references.citation: Emerg Infect Dis. 2008 Aug;14(8):1332-4
references.pmid: 18680679
references.citation: J Clin Virol. 2008 Nov;43(3):302-6
references.pmid: 18805051
references.citation: Pediatr Infect Dis J. 2008 Nov;27(11):969-73
references.pmid: 18833027
references.citation: Emerg Infect Dis. 2009 Sep;15(9):1423-30
references.pmid: 19788810
references.citation: Clin Lab Med. 2009 Dec;29(4):695-713
references.pmid: 19892229
references.citation: Pediatr Pulmonol. 2010 Feb;45(2):118-9
references.pmid: 20091779
references.citation: Microbiol Immunol. 2010 May;54(5):276-81
references.pmid: 20536724
references.citation: PLoS One. 2012;7(3):e34353
references.pmid: 22479609