title: Perceptions, Attributions, and Emotions Toward Endocrine Therapy in Young Women with Breast Cancer.
abstract: OBJECTIVE
  The aims of this study were to describe symptoms attributed to endocrine therapy (ET) and perceptions of ET in a sample of young women with breast cancer and to explore whether these factors are associated with adherence to ET.
  
  
  METHODS
  An online questionnaire was completed by 106 young women taking ET for hormone receptor-positive breast cancer. In addition to demographic and medical characteristics, the survey assessed symptom attribution, emotions, and perceptions related to ET. A supplemental survey measuring adherence to ET was completed by 82/106 women. Means, medians, and frequency distributions were calculated for continuous and categorical covariates, respectively. An exploratory analysis evaluated whether adherence was associated with patient characteristics and views.
  
  
  RESULTS
  The mean age of respondents was 39 years (range 22-45 years). Two-thirds of women had stage 1 or 2 breast cancer. Women attributed an average of nine symptoms to ET; hot flashes, night sweats, and decreased libido were the most frequently attributed symptoms. Positive emotions toward ET were more common than negative emotions were, although only 48% of respondents believed that ET was essential. Women of higher financial status and those who reported more positive emotions toward ET reported greater adherence with ET. A significant difference in symptom attribution was not detected between less and more adherent respondents.
  
  
  CONCLUSIONS
  Young women's views regarding ET may play an important role in determining adherence behavior. Given that young women have a higher risk of recurrence, some of which may be attributable to ET non-adherence, further work is needed to confirm these findings and determine whether interventions designed to modify young women's perceptions of ET could promote adherence.
authors.affiliation: 1 Harvard Medical School , Boston, Massachusetts.
authors.forename: Hayley E
authors.initials: HE
authors.lastname: Walker
authors.affiliation: 1 Harvard Medical School , Boston, Massachusetts.|2 Dana-Farber Cancer Institute , Boston, Massachusetts.
authors.forename: Shoshana M
authors.initials: SM
authors.lastname: Rosenberg
authors.affiliation: 3 Departments of Psychology and Psychiatry/Biobehavioral Sciences and Jonsson Comprehensive Cancer Center, University of California , Los Angeles, California.
authors.forename: Annette L
authors.initials: AL
authors.lastname: Stanton
authors.affiliation: 4 The University of Auckland , Auckland, New Zealand .
authors.forename: Keith J
authors.initials: KJ
authors.lastname: Petrie
authors.affiliation: 1 Harvard Medical School , Boston, Massachusetts.|2 Dana-Farber Cancer Institute , Boston, Massachusetts.
authors.forename: Ann H
authors.initials: AH
authors.lastname: Partridge
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000523:psychology; D017024:Chemotherapy, Adjuvant; D004644:Emotions; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D019584:Hot Flashes / Q000139:chemically induced; D006801:Humans; D007989:Libido / Q000187:drug effects; D055118:Medication Adherence / Q000523:psychology; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012959:Socioeconomic Factors; D017741:Survivors / Q000523:psychology; D013546:Sweating / Q000187:drug effects; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D018931:Antineoplastic Agents, Hormonal
keywords: breast cancer; psychosocial; survivorship
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