title: APP Receptor? To Be or Not To Be.
abstract: Amyloid precursor protein (APP) and its metabolites play a key role in Alzheimer's disease pathogenesis. The idea that APP may function as a receptor has gained momentum based on its structural similarities to type I transmembrane receptors and the identification of putative APP ligands. We review the recent experimental evidence in support of this notion and discuss how this concept is viewed in the field. Specifically, we focus on the structural and functional characteristics of APP as a cell surface receptor, and on its interaction with adaptors and signaling proteins. We also address the importance of APP function as a receptor in Alzheimer's disease etiology and discuss how this function might be potentially important for the development of novel therapeutic approaches.
authors.affiliation: Departments of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL, 60637, USA.
authors.forename: Carole
authors.initials: C
authors.lastname: Deyts
authors.affiliation: Departments of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL, 60637, USA.
authors.forename: Gopal
authors.initials: G
authors.lastname: Thinakaran
authors.affiliation: Departments of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL, 60637, USA. Electronic address: aparent@uchicago.edu.
authors.forename: Angèle T
authors.initials: AT
authors.lastname: Parent
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D006801:Humans
chemical_list: D016564:Amyloid beta-Protein Precursor
keywords: Alzheimer's disease; amyloid precursor protein; cell surface receptors; signaling.
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