title: Pubertal outcome in a female with virilizing adrenocortical carcinoma.
abstract: Adrenocortical tumors are neoplasms that rarely occur in pediatric patients. Adrenocortical carcinoma (ACC) is even more uncommon, and is an aggressive malignancy with 5-year survival of 55% in a registry series. There is a lack of information on long-term endocrine outcome in survivors. We describe a 10-year follow-up in a patient who presented at 3 years 5 months with a 1-year history of axillary odor and 6 months' history of pubic hair development with an increased clitoral size. Androgen levels were increased and a pelvic sonogram revealed a suprarenal mass of the left kidney. The tumor was successfully removed. At 6 years 11 months, androgen levels increased again. Workup for tumor recurrence was negative and the findings likely represented early adrenarche. The patient had menarche at an appropriate time and attained a height appropriate for her family.
authors.forename: Emily
authors.initials: E
authors.lastname: Breidbart
authors.forename: Tamara
authors.initials: T
authors.lastname: Cameo
authors.forename: James H
authors.initials: JH
authors.lastname: Garvin
authors.forename: Hanina
authors.initials: H
authors.lastname: Hibshoosh
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Oberfield
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000473:pathology* / Q000601:surgery; D000315:Adrenalectomy; D018268:Adrenocortical Carcinoma / Q000473:pathology* / Q000601:surgery; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008572:Menarche; D011379:Prognosis; D011627:Puberty / Q000502:physiology*; D014770:Virilism / Q000473:pathology* / Q000601:surgery
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