title: Melatonin and Other Tryptophan Metabolites Produced by Yeasts: Implications in Cardiovascular and Neurodegenerative Diseases.
abstract: Yeast metabolism produces compounds derived from tryptophan, which are found in fermented beverages, such as wine and beer. In particular, melatonin and serotonin, may be relevant due to their bioactivity in humans. Indeed, the former is a neurohormone related to circadian rhythms, which also has a putative protective effect against degenerative diseases. Moreover, serotonin is a neurotransmitter itself, in addition to being a precursor of melatonin synthesis. This paper summarizes data reported on fermented beverages, to evaluate dietary intake. Additionally, the article reviews observed effects of yeast amino acid metabolites on the prevention of neurodegenerative diseases (Alzheimer's and Parkinson's) and angiogenesis, focusing on evidence of the molecular mechanism involved and identification of molecular targets.
authors.affiliation: Facultad de Farmacia, Universidad de Sevilla Sevilla, Spain.
authors.forename: Ruth
authors.initials: R
authors.lastname: Hornedo-Ortega
authors.affiliation: Facultad de Farmacia, Universidad de Sevilla Sevilla, Spain.
authors.forename: Ana B
authors.initials: AB
authors.lastname: Cerezo
authors.affiliation: Facultad de Farmacia, Universidad de Sevilla Sevilla, Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Troncoso
authors.affiliation: Facultad de Farmacia, Universidad de Sevilla Sevilla, Spain.
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Garcia-Parrilla
authors.affiliation: Facultad de Enología, Universitat Rovira i Virgili Tarragona, Spain.
authors.forename: Albert
authors.initials: A
authors.lastname: Mas
keywords: VEGF; beer; serotonin; tryptophol; wine; α-synuclein; β-amyloid
references.citation: Curr Neuropharmacol. 2009 Mar;7(1):9-36
references.pmid: 19721815
references.citation: Electrophoresis. 2010 Jul;31(13):2242-8
references.pmid: 20593400
references.citation: Neuroscience. 2011 Apr 28;180:229-37
references.pmid: 21354274
references.citation: J Pineal Res. 2008 Mar;44(2):121-6
references.pmid: 18289162
references.citation: J Biol Chem. 1998 Mar 27;273(13):7185-8
references.pmid: 9516407
references.citation: Am J Kidney Dis. 2007 Feb;49(2):186-93
references.pmid: 17261421
references.citation: Food Chem. 2014 Jun 15;153:151-6
references.pmid: 24491714
references.citation: J Mol Biol. 2002 Oct 4;322(5):1089-102
references.pmid: 12367530
references.citation: J Parkinsons Dis. 2013;3(1):1-11
references.pmid: 23938306
references.citation: Curr Metabolomics. 2013;1(3):191-209
references.pmid: 26078917
references.citation: J Pineal Res. 2012 Aug;53(1):21-8
references.pmid: 22017461
references.citation: J Neurosci. 2004 Jan 14;24(2):565-75
references.pmid: 14724257
references.citation: J Pineal Res. 2008 Jan;44(1):107-14
references.pmid: 18078456
references.citation: Neuro Endocrinol Lett. 2001;22(1):45-7
references.pmid: 11335879
references.citation: Biochemistry. 2003 Jul 8;42(26):7871-8
references.pmid: 12834338
references.citation: Neurology. 2006 May 23;66(10 Suppl 4):S24-36
references.pmid: 16717250
references.citation: Childs Nerv Syst. 2011 Jun;27(6):879-91
references.pmid: 21104186
references.citation: Life Sci. 1997;60(25):2255-71
references.pmid: 9194681
references.citation: Science. 2002 Jul 19;297(5580):353-6
references.pmid: 12130773
references.citation: Neurobiol Dis. 2009 Aug;35(2):165-76
references.pmid: 19303440
references.citation: J Pineal Res. 2012 Oct;53(3):219-24
references.pmid: 22515683
references.citation: Cell Mol Life Sci. 2006 Mar;63(5):601-15
references.pmid: 16465447
references.citation: Food Chem. 2014 Nov 15;163:6-15
references.pmid: 24912689
references.citation: Clin Nutr. 2009 Apr;28(2):188-91
references.pmid: 19249143
references.citation: Gerontology. 2010;56(1):3-14
references.pmid: 19752507
references.citation: Lancet Oncol. 2008 Feb;9(2):117-23
references.pmid: 18221915
references.citation: Cell. 2003 Jul 11;114(1):1-8
references.pmid: 12859888
references.citation: Curr Neuropharmacol. 2010 Sep;8(3):182-93
references.pmid: 21358969
references.citation: Biochem Biophys Res Commun. 2001 Jul 27;285(4):997-1006
references.pmid: 11467851
references.citation: Mol Nutr Food Res. 2015 Mar;59(3):401-12
references.pmid: 25546248
references.citation: J Pineal Res. 2013 May;54(4):373-80
references.pmid: 23013414
references.citation: J Physiol Pharmacol. 2005 Mar;56 Suppl 1:51-67
references.pmid: 15800385
references.citation: Biomed Res Int. 2014;2014:898045
references.pmid: 24895623
references.citation: PLoS One. 2014 Jan 09;9(1):e85311
references.pmid: 24416386
references.citation: F1000 Biol Rep. 2012;4:14
references.pmid: 22802875
references.citation: Cell. 1994 Jun 17;77(6):817-27
references.pmid: 8004671
references.citation: Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18091-6
references.pmid: 17986607
references.citation: Hypertension. 2010 Oct;56(4):675-81
references.pmid: 20733093
references.citation: Ann N Y Acad Sci. 1992 May 11;648:187-93
references.pmid: 1637046
references.citation: J Pineal Res. 2003 Sep;35(2):125-30
references.pmid: 12887656
references.citation: J Neurol Neurosurg Psychiatry. 1999 Feb;66(2):137-47
references.pmid: 10071091
references.citation: Neuron. 1995 Feb;14(2):467-75
references.pmid: 7857654
references.citation: J Biol Chem. 2008 Dec 12;283(50):34887-95
references.pmid: 18922792
references.citation: J Pineal Res. 1998 Apr;24(3):179-92
references.pmid: 9551855
references.citation: J Mol Neurosci. 1997 Oct;9(2):75-92
references.pmid: 9407389
references.citation: Biosci Rep. 2001 Dec;21(6):789-800
references.pmid: 12166828
references.citation: Biochim Biophys Acta. 2010 Jan;1802(1):2-10
references.pmid: 19853658
references.citation: CA Cancer J Clin. 2010 Jul-Aug;60(4):222-43
references.pmid: 20554717
references.citation: J Pineal Res. 1998 Mar;24(2):83-9
references.pmid: 9510432
references.citation: Genes Dev. 2006 May 1;20(9):1045-9
references.pmid: 16651650
references.citation: Cancer Metastasis Rev. 1993 Sep;12(3-4):303-24
references.pmid: 8281615
references.citation: Nat Clin Pract Neurol. 2008 Nov;4(11):600-9
references.pmid: 18978800
references.citation: Endocrinology. 1997 Feb;138(2):627-34
references.pmid: 9002996
references.citation: Biochemistry. 2005 Apr 5;44(13):4977-83
references.pmid: 15794636
references.citation: Ann Neurol. 2002 Jan;51(1):82-92
references.pmid: 11782987
references.citation: J Cancer. 2015 Jan 01;6(1):19-28
references.pmid: 25553085
references.citation: J Mass Spectrom. 2001 Nov;36(11):1226-9
references.pmid: 11747119
references.citation: PLoS One. 2008 Apr 02;3(4):e1867
references.pmid: 18382657
references.citation: Eur J Clin Pharmacol. 2015 Aug;71(8):901-9
references.pmid: 26008214
references.citation: Food Chem. 2011 Jun 15;126(4):1608-13
references.pmid: 25213934
references.citation: Clin Lab. 2010;56(9-10):441-8
references.pmid: 21086789
references.citation: Nat Med. 2001 Apr;7(4):425-9
references.pmid: 11283668
references.citation: J Neurochem. 2003 Jun;85(5):1101-8
references.pmid: 12753069
references.citation: Anticancer Agents Med Chem. 2014;14 (9):1302-11
references.pmid: 25323035
references.citation: J Pineal Res. 2004 Sep;37(2):129-36
references.pmid: 15298672
references.citation: J Pineal Res. 2007 Mar;42(2):125-30
references.pmid: 17286743
references.citation: Neurobiol Aging. 2012 Sep;33(9):2172-85
references.pmid: 22118903
references.citation: Oncologist. 2001;6 Suppl 5:32-9
references.pmid: 11700390
references.citation: Nature. 1997 Aug 28;388(6645):839-40
references.pmid: 9278044
references.citation: J Biol Chem. 2004 Jun 25;279(26):26846-57
references.pmid: 15096521
references.citation: Trends Neurosci. 2008 Sep;31(9):454-63
references.pmid: 18675468
references.citation: Electrophoresis. 2011 Oct;32(20):2809-15
references.pmid: 21922500
references.citation: J Pineal Res. 1999 Apr;26(3):137-46
references.pmid: 10231726
references.citation: Nat Rev Cancer. 2003 Jun;3(6):401-10
references.pmid: 12778130
references.citation: Biophys J. 1991 Nov;60(5):1190-201
references.pmid: 1760507
references.citation: J Pineal Res. 2014 Jan;56(1):31-8
references.pmid: 24117835
references.citation: J Pineal Res. 2010 Apr;48(3):230-8
references.pmid: 20136701
references.citation: Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2309-14
references.pmid: 16321801
references.citation: J Pineal Res. 2007 Sep;43(2):163-71
references.pmid: 17645694
references.citation: Exp Physiol. 2008 Jan;93(1):116-20
references.pmid: 17911359
references.citation: Free Radic Res. 2008 Jul;42(7):661-73
references.pmid: 18654881
references.citation: J Pineal Res. 2013 Apr;54(3):322-33
references.pmid: 23171152
references.citation: J Neurosci. 1997 Mar 1;17(5):1683-90
references.pmid: 9030627
references.citation: J Mol Biol. 1997 Jun 6;269(2):214-24
references.pmid: 9191066
references.citation: J Neuropathol Exp Neurol. 1996 Mar;55(3):259-72
references.pmid: 8786384
references.citation: Circulation. 2005 Sep 20;112(12):1813-24
references.pmid: 16172288
references.citation: J Clin Invest. 2005 May;115(5):1121-9
references.pmid: 15864339
references.citation: J Neurosci. 1993 Apr;13(4):1676-87
references.pmid: 8463843
references.citation: Food Chem. 2013 Nov 15;141(2):1345-53
references.pmid: 23790923
references.citation: J Neurosci. 2003 Jun 15;23(12):5088-95
references.pmid: 12832532
references.citation: J Pineal Res. 2012 Mar;52(2):236-43
references.pmid: 21913973
references.citation: Nature. 2005 Dec 15;438(7070):967-74
references.pmid: 16355214
references.citation: FEBS J. 2007 Dec;274(24):6415-25
references.pmid: 18028426