title: MicroRNA-141 inhibits vascular smooth muscle cell proliferation through targeting PAPP-A.
abstract: It is well known that ox-LDL plays key roles in the development of atherosclerosis, partly by inducing vascular smooth muscle cells (VSMCs) proliferation. Recent findings have revealed that microRNAs, a class of small noncoding RNAs, could regulate cell proliferation in many physiological and pathological conditions. However, the role and function of miRNAs on ox-LDL induced VSMC proliferation are not fully elucidated. In this study, we showed that ox-LDL could suppress miR-141 expression and inhibition of miR-141 could promote VSMCs proliferation. Moreover, we found that PAPPA was the direct target gene of miR-141. Overexpression of PAPPA impaired the miR-141-induced inhibition of proliferation in the VSMCs. Taken together; miR-141 may play important roles in ox-LDL-induced abnormal proliferation of the VSMC.
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Bainan
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Ming
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Hongsong
authors.initials: H
authors.lastname: Qin
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yue
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Yannan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Bin
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Qingzhi
authors.initials: Q
authors.lastname: Hao
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Fuchen
authors.initials: F
authors.lastname: Song
authors.affiliation: Department of Peripheral Vascular, Affiliated Hospital of Shandong Traditional Chinese Medicine University Jinan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Ji
mesh_terms: D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation; D006801:Humans; D008077:Lipoproteins, LDL / Q000494:pharmacology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D032389:Myocytes, Smooth Muscle / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D011266:Pregnancy-Associated Plasma Protein-A / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013997:Time Factors; D014162:Transfection
chemical_list: D008077:Lipoproteins, LDL; C533895:MIRN141 microRNA, human; D035683:MicroRNAs; C099252:oxidized low density lipoprotein; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human
keywords: Atherosclerosis; miR-141; ox-LDL; proliferation; vascular smooth muscle cells
references.citation: Biochim Biophys Acta. 2014 Sep;1843(9):2114-21
references.pmid: 24937190
references.citation: J Int Med Res. 2010 Mar-Apr;38(2):625-32
references.pmid: 20515576
references.citation: Spine (Phila Pa 1976). 2008 Jun 15;33(14):E447-54
references.pmid: 18552658
references.citation: Clin Invest Med. 2008;31(2):E85-9
references.pmid: 18377765
references.citation: Int J Cardiol. 2013 Sep 30;168(2):1378-85
references.pmid: 23305858
references.citation: Int J Mol Sci. 2013;14(11):22708-20
references.pmid: 24252910
references.citation: Endocrinology. 2006 Feb;147(2):885-90
references.pmid: 16269458
references.citation: J Mol Cell Cardiol. 2014 Jan;66:94-105
references.pmid: 24001939
references.citation: Cell Biochem Funct. 2014 Mar;32(2):209-16
references.pmid: 24604335
references.citation: Methods Mol Biol. 2012;863:241-51
references.pmid: 22359297
references.citation: Circ Res. 2009 Feb 27;104(4):476-87
references.pmid: 19150885
references.citation: Lancet Oncol. 2010 Feb;11(2):136-46
references.pmid: 20022810
references.citation: Cell Signal. 2014 Apr;26(4):724-9
references.pmid: 24388835
references.citation: J Hypertens. 2011 Aug;29(8):1560-8
references.pmid: 21720271
references.citation: Int J Mol Cell Med. 2013 Spring;2(2):50-7
references.pmid: 24551791
references.citation: Cardiovasc Res. 2013 Nov 1;100(2):272-9
references.pmid: 23821525
references.citation: J Biol Chem. 2011 Aug 12;286(32):28312-21
references.pmid: 21685392
references.citation: Drug News Perspect. 2009 Jul-Aug;22(6):341-8
references.pmid: 19771323
references.citation: Circulation. 2012 Sep 11;126(11 Suppl 1):S81-90
references.pmid: 22965997
references.citation: Cell Cycle. 2009 Nov 1;8(21):3469-73
references.pmid: 19829088
references.citation: Mediators Inflamm. 2013;2013:152786
references.pmid: 23935243
references.citation: Front Biosci (Landmark Ed). 2013;18:788-94
references.pmid: 23276964
references.citation: Arterioscler Thromb Vasc Biol. 2001 Mar;21(3):335-41
references.pmid: 11231911
references.citation: BMB Rep. 2012 Aug;45(8):464-9
references.pmid: 22917031
references.citation: Curr Opin Cardiol. 2011 May;26(3):181-9
references.pmid: 21464712
references.citation: Cell Death Differ. 2009 Dec;16(12):1590-8
references.pmid: 19816508
references.citation: Atherosclerosis. 2009 Apr;203(2):346-52
references.pmid: 18789800
references.citation: Clin Cancer Res. 2014 May 15;20(10):2617-30
references.pmid: 24647573
references.citation: Int J Cardiol. 2007 May 2;117(3):370-2
references.pmid: 17157395
references.citation: Cardiovasc Drugs Ther. 2011 Oct;25(5):477-87
references.pmid: 21881851
references.citation: J Cell Biol. 2010 Apr 5;189(1):13-22
references.pmid: 20351064
references.citation: Kaohsiung J Med Sci. 2012 Dec;28(12):631-40
references.pmid: 23217354
references.citation: Mediators Inflamm. 2013;2013:714653
references.pmid: 24222937