title: Genetics and Epigenetics of Chronic Allograft Dysfunction in Kidney Transplants.
abstract: Chronic allograft dysfunction is the most common cause of allograft lost. Chronic allograft dysfunction happens as a result of complex interactions at the molecular and cellular levels. Genetic and environmental factors both influence the evolution and progression of the chronic allograft dysfunction. Epigenetic modification could be considered as a therapeutically modifiable element to pause the fibrosis process through novel strategies. In this review, the PubMed database was searched for English-language articles on these new areas.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Zununi Vahed
authors.forename: Nasser
authors.initials: N
authors.lastname: Samadi
authors.forename: Elmira
authors.initials: E
authors.lastname: Mostafidi
authors.affiliation: Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ardalan34@yahoo.com.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Ardalan
authors.forename: Yadollah
authors.initials: Y
authors.lastname: Omidi
mesh_terms: D064591:Allografts / Q000473:pathology / Q000503:physiopathology*; D002908:Chronic Disease; D044127:Epigenesis, Genetic; D005355:Fibrosis; D014644:Genetic Variation; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D007684:Kidney Tubules / Q000473:pathology*; D035683:MicroRNAs / Q000235:genetics*; D055031:Primary Graft Dysfunction / Q000235:genetics* / Q000503:physiopathology
chemical_list: D035683:MicroRNAs