title: Peroxidase-positive Auer bodies in plasma cells in multiple myeloma: a case report.
abstract: Reports of clinical cases with Auer bodies in the plasma cells in multiple myeloma (MM) are rare; however, most of those reported contain peroxidase (POX)-negative Auer bodies rather than the POX-positive Auer bodies observed in myeloid progenitors, indicating differences in their chemical properties. Furthermore, the cases with POX-positive Auer bodies similar to those observed in myeloid cells are extremely rare in non-myeloid cells. Here, we report the clinical features, laboratory investigations, diagnosis and treatment of a case of MM with POX-positive Auer bodies in plasma cells and review related the literature to advance the prognostic evaluation, diagnosis and treatment of similar cases.
authors.affiliation: Department of Hematology, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Hematology, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
authors.forename: Li
authors.initials: L
authors.lastname: An
authors.affiliation: Department of Hematology, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Hematology, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
authors.forename: Xue-Rui
authors.initials: XR
authors.lastname: Ren
authors.affiliation: Department of Hematology, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
authors.forename: Jing-Wen
authors.initials: JW
authors.lastname: Song
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001856:Bone Marrow Examination; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D002479:Inclusion Bodies / Q000201:enzymology* / Q000473:pathology; D007621:Karyotyping; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D009195:Peroxidase / Q000032:analysis*; D010950:Plasma Cells / Q000201:enzymology* / Q000473:pathology; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D009195:Peroxidase
keywords: Multiple myeloma; auer body; peroxidase; plasma cell
references.citation: Leukemia. 2002 Jan;16(1):152-4
references.pmid: 11840276
references.citation: Blood. 1966 Apr;27(4):499-510
references.pmid: 5219017
references.citation: Nihon Ketsueki Gakkai Zasshi. 1979 Jun;42(3):421-7
references.pmid: 227215
references.citation: Acta Haematol. 1987;77(2):115-9
references.pmid: 3037836
references.citation: Blood. 1960 Apr;15:449-65
references.pmid: 13824741
references.citation: Oncogene. 2007 Feb 26;26(9):1297-305
references.pmid: 17322915
references.citation: Hum Pathol. 2007 Sep;38(9):1293-304
references.pmid: 17707260
references.citation: Ann Diagn Pathol. 2010 Aug;14(4):292-5
references.pmid: 20637437
references.citation: Mayo Clin Proc. 2013 Apr;88(4):360-76
references.pmid: 23541011