title: Distribution of Anti-Factor Xa Activity in Patients on Edoxaban Therapy for Non-Valvular Atrial Fibrillation.
abstract: BACKGROUND
  The distribution of anti-factor Xa activity (AXA) values in non-valvular atrial fibrillation (NVAF) patients on edoxaban therapy has not been fully elucidated.
  
  
  RESULTS
  The steady-state trough and peak AXA values were measured in 66 NVAF patients. The trough AXA value did not differ significantly between the 60-mg and the 30-mg OD groups (0.17±0.13 IU/ml vs. 0.12±0.11 IU/ml, respectively; P=0.17). Similarly, the peak AXA value did not differ significantly between the 2 groups (1.45±0.81 IU/ml vs. 1.25±0.48 IU/ml, respectively; P=0.26).
  
  
  CONCLUSIONS
  Recommended dosing should be followed for sufficient efficacy of edoxaban. (Circ J 2016; 80: 745-747).
authors.affiliation: Department of Cardiovascular Medicine, Tosei General Hospital.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osanai
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ajioka
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Masutomi
authors.forename: Tasuku
authors.initials: T
authors.lastname: Kuwayama
authors.forename: Sota
authors.initials: S
authors.lastname: Ishihama
authors.forename: Maki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kanbara
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Inoue
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Asano
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Sakai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001281:Atrial Fibrillation / Q000097:blood* / Q000188:drug therapy*; D065427:Factor Xa Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D013844:Thiazoles / Q000008:administration & dosage* / Q000493:pharmacokinetics*
chemical_list: D065427:Factor Xa Inhibitors; D011725:Pyridines; D013844:Thiazoles; C552171:edoxaban