title: Evaluation of the matrix effect on gas chromatography--mass spectrometry with carrier gas containing ethylene glycol as an analyte protectant.
abstract: The consequences of matrix effects in GC are a major issue of concern in pesticide residue analysis. The aim of this study was to evaluate the applicability of an analyte protectant generator in pesticide residue analysis using a GC-MS system. The technique is based on continuous introduction of ethylene glycol into the carrier gas. Ethylene glycol as an analyte protectant effectively compensated the matrix effects in agricultural product extracts. All peak intensities were increased by this technique without affecting the GC-MS performance. Calibration curves for ethylene glycol in the GC-MS system with various degrees of pollution were compared and similar response enhancements were observed. This result suggests a convenient multi-residue GC-MS method using an analyte protectant generator instead of the conventional compensation method for matrix-induced response enhancement adding the mixture of analyte protectants into both neat and sample solutions.
authors.affiliation: Food Analysis Technology Center SUNATEC, 9-5 Akahorishinmachi, Yokkaichi, Mie 510-0825, Japan; Collage of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan. Electronic address: tfujiyoshi@mac.or.jp.
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Fujiyoshi
authors.affiliation: Collage of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Ikami
authors.affiliation: Food Analysis Technology Center SUNATEC, 9-5 Akahorishinmachi, Yokkaichi, Mie 510-0825, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sato
authors.affiliation: Food Analysis Technology Center SUNATEC, 9-5 Akahorishinmachi, Yokkaichi, Mie 510-0825, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Kikukawa
authors.affiliation: Food Analysis Technology Center SUNATEC, 9-5 Akahorishinmachi, Yokkaichi, Mie 510-0825, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Toyota Central R&D Labs., Inc., 41-1 Yokomichi, Nagakute, Aichi 480-1192, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.affiliation: Collage of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamamoto
mesh_terms: D002138:Calibration; D019855:Ethylene Glycol / Q000737:chemistry*; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010573:Pesticide Residues / Q000032:analysis*
chemical_list: D010573:Pesticide Residues; D019855:Ethylene Glycol
keywords: Analyte protectant generator; Ethylene glycol; GC–MS; Matrix effect; Pesticide residue analysis