title: Phenyltrimethylammonium Salts as Methylation Reagents in the Nickel-Catalyzed Methylation of C-H Bonds.
abstract: Methylation of C(sp(2))-H bonds was achieved through the Ni(II)-catalyzed reaction of benzamides with phenyltrimethylammonium bromide or iodide as the source of the methyl group. The reaction has a broad scope and shows high functional-group compatibility. The reaction is also applicable to the methylation of C(sp(3))-H bonds in aliphatic amides.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Uemura
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors.forename: Mao
authors.initials: M
authors.lastname: Yamaguchi
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. chatani@chem.eng.osaka-u.ac.jp.
authors.forename: Naoto
authors.identifier: http://orcid.org/0000-0001-8330-7478
authors.initials: N
authors.lastname: Chatani
keywords: C−H activation; chelation assistance; methylation; nickel; phenyltrimethylammonium iodide