title: Analysis of Glial Distribution in Drosophila Adult Brains.
abstract: Neurons and glia are the two major cell types in the nervous system and work closely with each other to program neuronal interplay. Traditionally, neurons are thought to be the major cells that actively regulate processes like synapse formation, plasticity, and behavioral output. Glia, on the other hand, serve a more supporting role. To date, accumulating evidence has suggested that glia are active participants in virtually every aspect of neuronal function. Despite this, fundamental features of how glia interact with neurons, and their spatial relationships, remain elusive. Here, we describe the glial cell population in Drosophila adult brains. Glial cells extend and tightly associate their processes with major structures such as the mushroom body (MB), ellipsoid body (EB), and antennal lobe (AL) in the brain. Glial cells are distributed in a more concentrated manner in the MB. Furthermore, subsets of glia exhibit distinctive association patterns around different neuronal structures. Whereas processes extended by astrocyte-like glia and ensheathing glia wrap around the MB and infiltrate into the EB and AL, cortex glia stay where cell bodies of neurons are and remain outside of the synaptic regions structured by EB or AL.
authors.affiliation: Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai, 200092, China.|Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai, 200092, China.|Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai, 200092, China.
authors.forename: Jiayao
authors.initials: J
authors.lastname: Ou
authors.affiliation: Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai, 200092, China.|Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai, 200092, China.|Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai, 200092, China.
authors.forename: Zongbao
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai, 200092, China.|Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai, 200092, China.|Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai, 200092, China.
authors.forename: Li
authors.initials: L
authors.lastname: Song
authors.affiliation: Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai, 200092, China. margaret_ho@tongji.edu.cn.|Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai, 200092, China. margaret_ho@tongji.edu.cn.|Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai, 200092, China. margaret_ho@tongji.edu.cn.
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Ho
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001921:Brain / Q000166:cytology* / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D009457:Neuroglia / Q000502:physiology*; D060245:Tetraspanin 29 / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; C557617:GAL4 protein, Drosophila; D060245:Tetraspanin 29; D014157:Transcription Factors; D049452:Green Fluorescent Proteins
keywords: Drosophila; Glia; Mushroom body
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