title: Helicobacter pylori colonization of the oral cavity: A milestone discovery.
abstract: Over the past several years, the severity of Helicobacter pylori (H. pylori) infections has not significantly diminished. After successful eradication, the annual H. pylori recurrence rate is approximately 13% due to oral H. pylori infection. Established clinical diagnostic techniques do not identify an oral etiologic basis of H. pylori prior to gastric infection. There has been disagreement as to whether oral infection of H. pylori exists or not, with no definite conclusion. In medical practice, negative results with the urea breath test suggest that the stomach infection of H. pylori is cured in these patients. In fact, patients can present negative urea breath test results and yet exhibit H. pylori infection due to oral infection. The present paper provides evidence that H. pylori oral infection is nonetheless present, and the oral cavity represents a secondary site for H. pylori colonization.
authors.affiliation: John KC Yee, Research Lab of Oral H. pylori, Everett, WA 98208, United States.
authors.forename: John K C
authors.initials: JK
authors.lastname: Yee
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001431:Bacteriological Techniques; D001944:Breath Tests; D024881:Drug Resistance, Bacterial; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000635:transmission; D016480:Helicobacter pylori / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification*; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013270:Stomach / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antigen test for oral urease; Cell culture; Helicobacter pylori; Lysine and glycerol monolaurate mouthwash solution; Oral cavity
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