title: Distribution and Features of the Six Classes of Peroxiredoxins.
abstract: Peroxiredoxins are cysteine-dependent peroxide reductases that group into 6 different, structurally discernable classes. In 2011, our research team reported the application of a bioinformatic approach called active site profiling to extract active site-proximal sequence segments from the 29 distinct, structurally-characterized peroxiredoxins available at the time. These extracted sequences were then used to create unique profiles for the six groups which were subsequently used to search GenBank(nr), allowing identification of ∼3500 peroxiredoxin sequences and their respective subgroups. Summarized in this minireview are the features and phylogenetic distributions of each of these peroxiredoxin subgroups; an example is also provided illustrating the use of the web accessible, searchable database known as PREX to identify subfamily-specific peroxiredoxin sequences for the organism Vitis vinifera (grape).
authors.affiliation: Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: Leslie B
authors.initials: LB
authors.lastname: Poole
authors.affiliation: Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA ; Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Nelson
mesh_terms: D030562:Databases, Protein; D054464:Peroxiredoxins / Q000737:chemistry* / Q000145:classification* / Q000235:genetics; D010802:Phylogeny; D010940:Plant Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics; D020539:Sequence Analysis, Protein; D014584:User-Computer Interface; D027843:Vitis / Q000201:enzymology* / Q000235:genetics
chemical_list: D010940:Plant Proteins; D054464:Peroxiredoxins
keywords: active site profiling; bioinformatics; disulfide reductase; peroxide reductase; thiol peroxidase
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