title: [Gap junction and diabetic foot].
abstract: Gap junctions play a critical role in electrical synchronization and exchange of small molecules between neighboring cells; connexins are a family of structurally related transmembrane proteins that assemble to form vertebrate gap junctions. Hyperglycemia changes the structure gap junction proteins and their expression, resulting in obstruction of neural regeneration, vascular function and wound healing, and also promoting vascular atherosclerosis. These pathogenic factors would cause diabetic foot ulcers. This article reviews the involvement of connexins in pathogenesis of diabetic foot.
authors.affiliation: Department of Hypertension Institute, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Zou
authors.affiliation: Department of Hypertension Institute, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Tao
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
authors.forename: Yun-kai
authors.initials: YK
authors.lastname: Wang
mesh_terms: D050197:Atherosclerosis; D017630:Connexins / Q000378:metabolism*; D017719:Diabetic Foot / Q000473:pathology*; D017629:Gap Junctions / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology; D012038:Regeneration; D014945:Wound Healing
chemical_list: D017630:Connexins
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