title: Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System.
abstract: Sulfur dioxide (SO2) was previously regarded as a toxic gas in atmospheric pollutants. But it has been found to be endogenously generated from metabolism of sulfur-containing amino acids in mammals through transamination by aspartate aminotransferase (AAT). SO2 could be produced in cardiovascular tissues catalyzed by its synthase AAT. In recent years, studies revealed that SO2 had physiological effects on the cardiovascular system, including vasorelaxation and cardiac function regulation. In addition, the pathophysiological effects of SO2 were also determined. For example, SO2 ameliorated systemic hypertension and pulmonary hypertension, prevented the development of atherosclerosis, and protected against myocardial ischemia-reperfusion (I/R) injury and isoproterenol-induced myocardial injury. These findings suggested that endogenous SO2 was a novel gasotransmitter in the cardiovascular system and provided a new therapy target for cardiovascular diseases.
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Yaqian
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing 100191, China; Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing 100191, China.
authors.forename: Chaoshu
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China; Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing 100191, China.
authors.forename: Junbao
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Hongfang
authors.initials: H
authors.lastname: Jin
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism* / Q000503:physiopathology; D064426:Gasotransmitters / Q000378:metabolism*; D006801:Humans; D013458:Sulfur Dioxide / Q000378:metabolism*
chemical_list: D064426:Gasotransmitters; D013458:Sulfur Dioxide
references.citation: Chin Med J (Engl). 2014;127(21):3803-7
references.pmid: 25382339
references.citation: Zhonghua Yi Xue Za Zhi. 2008 Mar 25;88(12):830-4
references.pmid: 18756988
references.citation: Acta Pharmacol Sin. 2012 Aug;33(8):983-90
references.pmid: 22796764
references.citation: Vasc Health Risk Manag. 2015 Feb 27;11:173-83
references.pmid: 25767394
references.citation: Chin Med J (Engl). 2014;127(23):4110-3
references.pmid: 25430458
references.citation: Shock. 2005 Dec;24(6):529-34
references.pmid: 16317383
references.citation: Front Biosci (Elite Ed). 2011 Jan 01;3(2):736-49
references.pmid: 21196347
references.citation: Ann Biomed Eng. 1991;19(3):237-49
references.pmid: 1928868
references.citation: Oxid Med Cell Longev. 2015;2015:925167
references.pmid: 26078822
references.citation: Arch Biochem Biophys. 2005 Oct 15;442(2):187-95
references.pmid: 16168948
references.citation: Amino Acids. 2009 May;37(1):65-78
references.pmid: 19266154
references.citation: Biochem Soc Trans. 2007 Nov;35(Pt 5):1138-41
references.pmid: 17956296
references.citation: Environ Toxicol Pharmacol. 2015 May;39(3):1132-8
references.pmid: 25912853
references.citation: Eur J Pharmacol. 2009 Jan 5;602(1):117-23
references.pmid: 19049805
references.citation: Eur J Pharmacol. 2014 Nov 5;742:31-41
references.pmid: 25192964
references.citation: Int J Mol Sci. 2013 May 21;14(5):10465-82
references.pmid: 23698774
references.citation: Zhonghua Er Ke Za Zhi. 2011 Dec;49(12):890-4
references.pmid: 22336353
references.citation: Physiol Res. 2009;58(4):521-527
references.pmid: 18657003
references.citation: Eur J Pharmacol. 2010 Oct 25;645(1-3):143-50
references.pmid: 20674563
references.citation: Int J Mol Sci. 2013 Nov 08;14(11):22190-201
references.pmid: 24217229
references.citation: Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):173-9
references.pmid: 18988885
references.citation: Acta Pharmacol Sin. 2008 Oct;29(10):1157-66
references.pmid: 18817619
references.citation: Zhonghua Er Ke Za Zhi. 2014 Aug;52(8):625-9
references.pmid: 25224243
references.citation: Environ Health Perspect. 2011 Jul;119(7):921-6
references.pmid: 21356620
references.citation: Basic Res Cardiol. 2011 Sep;106(5):865-78
references.pmid: 21468766
references.citation: Food Chem Toxicol. 2006 Mar;44(3):355-63
references.pmid: 16182427
references.citation: Amino Acids. 2004 Jun;26(3):243-54
references.pmid: 15221504
references.citation: Hypertension. 2001 Sep;38(3 Pt 2):581-7
references.pmid: 11566935
references.citation: Chemosphere. 2012 Oct;89(5):579-84
references.pmid: 22763331
references.citation: Biochem Biophys Res Commun. 2003 Nov 21;311(3):728-34
references.pmid: 14623333
references.citation: J Am Soc Nephrol. 2000 May;11(5):923-927
references.pmid: 10770971
references.citation: Clin Exp Pharmacol Physiol. 2011 Jul;38(7):416-22
references.pmid: 21501210
references.citation: Sheng Li Xue Bao. 2011 Dec 25;63(6):593-600
references.pmid: 22193456
references.citation: Mutat Res. 1977;39(2):149-75
references.pmid: 405577
references.citation: Lab Invest. 2011 Jan;91(1):12-23
references.pmid: 20733562
references.citation: Shock. 2004 Feb;21(2):99-102
references.pmid: 14752280
references.citation: Lab Invest. 2010 Jan;90(1):68-82
references.pmid: 19823174
references.citation: Exp Biol Med (Maywood). 2012 Jul;237(7):867-72
references.pmid: 22802518
references.citation: Circulation. 1981 Nov;64(5):873-7
references.pmid: 7026082
references.citation: Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2334-41
references.pmid: 15964923
references.citation: Inhal Toxicol. 2008 Feb;20(4):435-44
references.pmid: 18302051
references.citation: Nitric Oxide. 2013 Aug 1;32:56-61
references.pmid: 23629152
references.citation: Circulation. 2014 Sep 9;130(11):880-891
references.pmid: 24993099
references.citation: Neurochem Int. 2008 Jan;52(1-2):155-65
references.pmid: 17629356
references.citation: Inhal Toxicol. 2007 Sep;19(11):979-86
references.pmid: 17849282
references.citation: Fundam Appl Toxicol. 1983 Jul-Aug;3(4):298-302
references.pmid: 6628892
references.citation: Cardiovasc Res. 2013 Jul 1;99(1):16-23
references.pmid: 23504550
references.citation: Atherosclerosis. 2011 Apr;215(2):323-30
references.pmid: 21300352
references.citation: Annu Rev Nutr. 1986;6:179-209
references.pmid: 3524616
references.citation: Trends Neurosci. 2001 Feb;24(2):99-106
references.pmid: 11164940
references.citation: Carcinogenesis. 1990 Sep;11(9):1635-9
references.pmid: 2119259
references.citation: Acta Pharmacol Sin. 2008 Aug;29(8):923-30
references.pmid: 18664325
references.citation: Environ Toxicol. 2012 Mar;27(3):175-84
references.pmid: 20607818
references.citation: Lab Invest. 1988 Dec;59(6):817-23
references.pmid: 3199796
references.citation: Arch Biochem Biophys. 2007 Nov 15;467(2):291-6
references.pmid: 17923104
references.citation: Biochem Biophys Res Commun. 2013 Apr 19;433(4):519-25
references.pmid: 23524260
references.citation: Inhal Toxicol. 2003 Aug;15(9):951-9
references.pmid: 12872180
references.citation: Arch Biochem Biophys. 1956 Apr;61(2):397-409
references.pmid: 13314623
references.citation: J Pharmacol Sci. 2012;118(1):14-24
references.pmid: 32092834
references.citation: Arch Biochem Biophys. 2008 Jul 15;475(2):109-14
references.pmid: 18455496
references.citation: Cell Biol Int. 1997 Dec;21(12):801-12
references.pmid: 9812344
references.citation: Zhonghua Yi Xue Za Zhi. 2008 May 13;88(18):1279-83
references.pmid: 18844104
references.citation: Cell Death Dis. 2014 May 22;5:e1251
references.pmid: 24853429
references.citation: Nitric Oxide. 2009 May;20(3):166-74
references.pmid: 19135162
references.citation: Biochem J. 2010 Jan 27;426(1):43-53
references.pmid: 19925454
references.citation: Eur J Pharmacol. 2011 Nov 16;670(1):1-6
references.pmid: 21925165
references.citation: Zhonghua Er Ke Za Zhi. 2008 Sep;46(9):675-9
references.pmid: 19099857
references.citation: Epidemiology. 2010 Jul;21(4):512-20
references.pmid: 20407379
references.citation: Ann N Y Acad Sci. 2007 Jan;1095:76-81
references.pmid: 17404020
references.citation: Mol Pharmacol. 1982 Nov;22(3):732-7
references.pmid: 6296662
references.citation: Inhal Toxicol. 2009 Dec;21(14):1223-8
references.pmid: 19922406
references.citation: Acta Pharmacol Sin. 2013 Apr;34(4):501-6
references.pmid: 23524571
references.citation: Histol Histopathol. 2012 Sep;27(9):1219-26
references.pmid: 22806909
references.citation: Clin Chem. 1995 Jun;41(6 Pt 1):897-903
references.pmid: 7768009
references.citation: Heart Vessels. 2012 Sep;27(5):505-16
references.pmid: 21969216