title: Salivary Cortisone Reflects Cortisol Exposure Under Physiological Conditions and After Hydrocortisone.
abstract: In this study we tested the use of salivary cortisol and cortisone as alternatives to serum cortisol. Salivary cortisol is often undetectable and contaminated by hydrocortisone. Salivary cortisone strongly reflects serum cortisol.
authors.affiliation: The University of Sheffield (M.D., R.F.H., M.J.W., R.J.R.), Sheffield S10 2RX, United Kingdom; Diurnal Limited (D.E.), Cardiff, United Kingdom; Institute of Metabolism and Systems Research (W.A.), University of Birmingham, Birmingham, B15 2TT, United Kingdom; and Department of Clinical Biochemistry (B.G.K.), University Hospital South Manchester, Manchester M23 9LT, United Kingdom.
authors.forename: Miguel
authors.initials: M
authors.lastname: Debono
authors.affiliation: The University of Sheffield (M.D., R.F.H., M.J.W., R.J.R.), Sheffield S10 2RX, United Kingdom; Diurnal Limited (D.E.), Cardiff, United Kingdom; Institute of Metabolism and Systems Research (W.A.), University of Birmingham, Birmingham, B15 2TT, United Kingdom; and Department of Clinical Biochemistry (B.G.K.), University Hospital South Manchester, Manchester M23 9LT, United Kingdom.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Harrison
authors.affiliation: The University of Sheffield (M.D., R.F.H., M.J.W., R.J.R.), Sheffield S10 2RX, United Kingdom; Diurnal Limited (D.E.), Cardiff, United Kingdom; Institute of Metabolism and Systems Research (W.A.), University of Birmingham, Birmingham, B15 2TT, United Kingdom; and Department of Clinical Biochemistry (B.G.K.), University Hospital South Manchester, Manchester M23 9LT, United Kingdom.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Whitaker
authors.affiliation: The University of Sheffield (M.D., R.F.H., M.J.W., R.J.R.), Sheffield S10 2RX, United Kingdom; Diurnal Limited (D.E.), Cardiff, United Kingdom; Institute of Metabolism and Systems Research (W.A.), University of Birmingham, Birmingham, B15 2TT, United Kingdom; and Department of Clinical Biochemistry (B.G.K.), University Hospital South Manchester, Manchester M23 9LT, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Eckland
authors.affiliation: The University of Sheffield (M.D., R.F.H., M.J.W., R.J.R.), Sheffield S10 2RX, United Kingdom; Diurnal Limited (D.E.), Cardiff, United Kingdom; Institute of Metabolism and Systems Research (W.A.), University of Birmingham, Birmingham, B15 2TT, United Kingdom; and Department of Clinical Biochemistry (B.G.K.), University Hospital South Manchester, Manchester M23 9LT, United Kingdom.
authors.forename: Wiebke
authors.initials: W
authors.lastname: Arlt
authors.affiliation: The University of Sheffield (M.D., R.F.H., M.J.W., R.J.R.), Sheffield S10 2RX, United Kingdom; Diurnal Limited (D.E.), Cardiff, United Kingdom; Institute of Metabolism and Systems Research (W.A.), University of Birmingham, Birmingham, B15 2TT, United Kingdom; and Department of Clinical Biochemistry (B.G.K.), University Hospital South Manchester, Manchester M23 9LT, United Kingdom.
authors.forename: Brian G
authors.initials: BG
authors.lastname: Keevil
authors.affiliation: The University of Sheffield (M.D., R.F.H., M.J.W., R.J.R.), Sheffield S10 2RX, United Kingdom; Diurnal Limited (D.E.), Cardiff, United Kingdom; Institute of Metabolism and Systems Research (W.A.), University of Birmingham, Birmingham, B15 2TT, United Kingdom; and Department of Clinical Biochemistry (B.G.K.), University Hospital South Manchester, Manchester M23 9LT, United Kingdom.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Ross
mesh_terms: D000328:Adult; D002853:Chromatography, Liquid; D002940:Circadian Rhythm; D003348:Cortisone / Q000032:analysis*; D018592:Cross-Over Studies; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D011446:Prospective Studies; D012463:Saliva / Q000737:chemistry*; D012469:Salivary Glands / Q000378:metabolism* / Q000473:pathology; D053719:Tandem Mass Spectrometry
chemical_list: D003348:Cortisone; D006854:Hydrocortisone