title: Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study.
abstract: Spinal osteoarthritis has been suggested as a risk factor for vertebral fractures. However, results are conflicting: most of the data are focused on the lumbar region, and referred to postmenopausal women, whereas data for men are scarce. The aim of this study is to assess the relationship between spinal osteoarthritis and vertebral fractures in men over 50 years of age. We conducted a cross-sectional study, nested in a prospective population-based cohort, including 507 community-dwelling men, 93 of them with at least one vertebral fracture. Vertebral fractures, osteophytosis, and disc space narrowing (DSN) were assessed by lateral thoracic and lumbar radiographs. Anthropometric, clinical, and densitometric variables were also analyzed. A multiple logistic regression model was performed. Eighty-five percent of vertebral fractures were located at the thoracic spine. Osteophytosis and DSN showed a bimodal distribution, with major frequency peaks at mid- and distal lumbar spine. The three distributions overlapped around the T9 vertebra. We did not find any relationship between lumbar osteoarthritis and vertebral fractures. Nevertheless, thoracic osteophytosis (OR, 1.84; 95 % CI, 1.05-3.17; p = 0.03) and DSN (OR, 2.52; 95 % CI, 1.43-4.46; p = 0.001) were found to be independently associated with prevalent vertebral fractures, after adjusting for confounders. Our results suggest a positive relationship between radiologic osteoarthritic changes at the thoracic spine and prevalent vertebral fractures in men more than 50 years of age. Osteoarthritis may act as a local risk factor, in addition to other mechanical factors, resulting in a greater propensity to fracture, especially at the mid-thoracic region.
authors.affiliation: "Camargo-Interior" Primary Care Center, Servicio Cántabro de Salud, OSPC, Muriedas, Cantabria, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Pariente
authors.affiliation: Bone Metabolism Unit, Department of Internal Medicine, Hospital Marqués de Valdecilla, University of Cantabria, IDIVAL, RETICEF, 39008, Santander, Cantabria, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Olmos
authors.affiliation: Department of Radiology, University Hospital Marqués de Valdecilla, Santander, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Landeras
authors.affiliation: Bone Metabolism Unit, Department of Internal Medicine, Hospital Marqués de Valdecilla, University of Cantabria, IDIVAL, RETICEF, 39008, Santander, Cantabria, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Nan
authors.affiliation: Bone Metabolism Unit, Department of Internal Medicine, Hospital Marqués de Valdecilla, University of Cantabria, IDIVAL, RETICEF, 39008, Santander, Cantabria, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: González-Macías
authors.affiliation: Bone Metabolism Unit, Department of Internal Medicine, Hospital Marqués de Valdecilla, University of Cantabria, IDIVAL, RETICEF, 39008, Santander, Cantabria, Spain. hernandezjluis@gmail.com.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Hernández
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D055013:Osteoarthritis, Spine / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism; D011446:Prospective Studies; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D013128:Spinal Osteophytosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism
keywords: Male; Osteoarthritis; Osteophytosis; Spine; Vertebral fracture
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