title: Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology.
abstract: In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules acting in a paracrine fashion on resident cells. The data suggest the existence of a tissue microenvironment where stem cell factors influence cell survival, inflammation, angiogenesis, repair, and regeneration in a temporal and spatial manner.
authors.affiliation: From the Department of Medicine, Mandel Center for Hypertension Research and Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC.
authors.forename: Conrad P
authors.initials: CP
authors.lastname: Hodgkinson
authors.affiliation: From the Department of Medicine, Mandel Center for Hypertension Research and Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC.
authors.forename: Akshay
authors.initials: A
authors.lastname: Bareja
authors.affiliation: From the Department of Medicine, Mandel Center for Hypertension Research and Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC.
authors.forename: José A
authors.initials: JA
authors.lastname: Gomez
authors.affiliation: From the Department of Medicine, Mandel Center for Hypertension Research and Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC. vdzau@nas.edu.
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Dzau
mesh_terms: D000818:Animals; D002309:Cardiology / Q000379:methods / Q000639:trends*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000628:therapy*; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D032383:Myocytes, Cardiac / Q000502:physiology / Q000637:transplantation; D019899:Paracrine Communication / Q000502:physiology*; D044968:Regenerative Medicine / Q000379:methods / Q000639:trends*; D033581:Stem Cell Transplantation / Q000379:methods / Q000639:trends
keywords: fibroblast growth factor; heart diseases; myocardial infarction; regeneration; stem cells
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