title: Cancer stem cells in prostate cancer.
abstract: Prostate cancer (P-Ca) remains a leading cause of cancer-related death in men. Lately, increasing evidence for a hierarchically organized cancer stem cell (CSC) model emerged for different tumors entities, including P-Ca. CSCs are defined by several characteristics including self-renewal, pluripotency and tumorigenicity and are thought to be responsible for tumor recurrence, metastasis and cancer related death. In this review we discuss the recent research in the field of CSCs, its limitations and therapeutical implications in general and specifically in P-Ca.
authors.affiliation: Department of Urology, University of Bern, Bern, Switzerland.
authors.forename: Felix
authors.initials: F
authors.lastname: Moltzahn
authors.affiliation: Department of Urology, University of Bern, Bern, Switzerland.
authors.forename: George N
authors.initials: GN
authors.lastname: Thalmann
keywords: Cancer stem cells (CSCs); castration resistance; hierarchy; prostate cancer (P-Ca)
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