title: Recombinant growth hormone therapy in a girl with Costello syndrome: a 4-year observation.
abstract: BACKGROUND
  Costello syndrome is a rare syndrome of multiple congenital anomalies. The typical clinical traits include dysmorphic craniofacial features, skin hyperpigmentation and excess, feeding difficulties leading to severe postnatal growth retardation, short stature, joint hypermobility, and delayed psychomotor development. Additionally, Costello syndrome may present with an increased incidence of congenital heart disease, hypertrophic cardiomyopathy, and increased risk of both benign and malignant tumors. Furthermore, cases of patients with endocrine disorders such as adrenal insufficiency and endogenous growth hormone deficiency have also been documented.
  
  
  METHODS
  We present a patient with Costello syndrome who has been successfully treated with recombinant human growth hormone (rhGH) for almost 4 years.
  
  
  CONCLUSIONS
  The possibility of growth hormone (GH) treatment can be considered in cases of documented GH deficiency in patients with Costello syndrome, but only under close oncologic and cardiologic supervision.
authors.affiliation: Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University in Szczecin, Ulica Unii Lubelskiej 1, 71-252, Szczecin, Poland. ew.berus@gmail.com.
authors.forename: Ewa
authors.initials: E
authors.lastname: Blachowska
authors.affiliation: Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University in Szczecin, Ulica Unii Lubelskiej 1, 71-252, Szczecin, Poland. petrela1@wp.pl.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Petriczko
authors.affiliation: Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University in Szczecin, Ulica Unii Lubelskiej 1, 71-252, Szczecin, Poland. anitajozwa@wp.pl.
authors.forename: Anita
authors.initials: A
authors.lastname: Horodnicka-Józwa
authors.affiliation: Department of Medical Genetics, The Children's Memorial Health Institute, Warsaw, Poland. agatkas3@gmail.com.|Department of Pediatrics, Medical University of Warsaw, Warsaw, Poland. agatkas3@gmail.com.
authors.forename: Agata
authors.initials: A
authors.lastname: Skórka
authors.affiliation: Department of Medical Genetics, The Children's Memorial Health Institute, Warsaw, Poland. m.pelc@czd.pl.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Pelc
authors.affiliation: Department of Medical Genetics, The Children's Memorial Health Institute, Warsaw, Poland. m.walasek@czd.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Krajewska-Walasek
authors.affiliation: Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University in Szczecin, Ulica Unii Lubelskiej 1, 71-252, Szczecin, Poland. sekr.pediatrii@spsk1.szn.pl.
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Walczak
mesh_terms: D002675:Child, Preschool; D056685:Costello Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D003937:Diagnosis, Differential; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone
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