title: The palliative efficacy of modified Mohs paste for controlling canine and feline malignant skin wounds.
abstract: In veterinary medicine, the management of malignant skin wounds is highly challenging. We conducted a study on seven case animals (four dogs and three cats) which presented with malignant skin wounds. All seven animals had signs and symptoms which were controlled following treatment with a modified Mohs paste. Upon obtaining informed consent from their owners, the animals requiring management of malignant wounds were enrolled in this study. The modified Mohs paste was prepared by mixing zinc chloride, zinc oxide starch powder, glycerin, and distilled water. The modified Mohs paste was topically applied to and left to remain on the malignant wounds for one hour, under controlled conditions. Once the paste was removed, the wounds were irrigated with a solution of sterile saline. At the first examination, the wounds of each animal were observed for signs of exudate, malodor, and bleeding. In every case, visible improvement was observed immediately after the modified Mohs paste treatment. Specifically, the size of the malignant wounds, and the number of times the dressing gauze required changing, significantly decreased (p < 0.05 and p < 0.01, respectively). The open malignant skin wounds caused by mammary gland tumors disappeared in two cases. The Mohs paste has been shown to be a viable option for the palliative treatment in canine and feline malignant skin wound management.
authors.affiliation: a Veterinary Teaching Hospital , Azabu University , Sagamihara , Kanagawa , Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fukuyama
authors.affiliation: a Veterinary Teaching Hospital , Azabu University , Sagamihara , Kanagawa , Japan.
authors.forename: Shinpei
authors.initials: S
authors.lastname: Kawarai
authors.affiliation: b Takashimadaira Tezuka Animal Hospital , Tokyo , Japan.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Tezuka
authors.affiliation: c Department of Pathobiological Sciences , Louisiana State University , Baton Rouge , LA , USA.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawabata
authors.affiliation: a Veterinary Teaching Hospital , Azabu University , Sagamihara , Kanagawa , Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Maruo
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002415:Cats / Q000293:injuries*; D002712:Chlorides / Q000032:analysis / Q000627:therapeutic use*; D004285:Dogs / Q000293:injuries*; D005260:Female; D007564:Japan; D008297:Male; D009824:Ointments / Q000032:analysis / Q000627:therapeutic use*; D010166:Palliative Care / Q000379:methods*; D016896:Treatment Outcome; D014945:Wound Healing; D017967:Zinc Compounds / Q000032:analysis / Q000627:therapeutic use*
chemical_list: D002712:Chlorides; C583017:Mohs' paste; D009824:Ointments; D017967:Zinc Compounds
keywords: Cat; Mohs paste; dog; palliative treatment; wound management