title: How effective is efinaconazole in the management of onychomycosis?
abstract: BACKGROUND
  Onychomycosis is a fungal nail infection that is difficult to treat due to poor accessibility of drugs into the nail plate. Although oral antifungals can reach the nail apparatus more readily, these therapies may not be suitable or desirable for some patients (e.g., multiple medications or immunocompromised). Efinaconazole 10% solution is a new topical antifungal recently approved and sold in Canada, the United States and Japan for the treatment of mild-to-moderate toenail onychomycosis. Efinaconazole has broad-spectrum antifungal activity against dermatophytes, nondermatophyte molds and yeasts, and high ungual penetration due to its low keratin binding properties.
  
  
  METHODS
  The objective of this article is to summarize recent data regarding the efficacy, safety and pharmacokinetic properties of efinaconazole in the treatment of onychomycosis.
  
  
  CONCLUSIONS
  Efinaconazole is a safe and effective treatment for onychomycosis that can be used in a wide range of patients due to its broad-spectrum antifungal activity and low rate of treatment-related adverse events. When incomplete response to oral therapy or devices (e.g. laser therapy) is encountered, efinaconazole could be used in combination to improve success rates. Alternatively, efinaconazole could be used as a 'closer' drug, in an effort to provide cure when the initial oral or device therapy has resulted in an incomplete response.
authors.affiliation: a Department of Medicine , University of Toronto School of Medicine , Toronto , Ontario , Canada.|b Mediprobe Research Inc ., London , Ontario , Canada.
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Gupta
authors.affiliation: b Mediprobe Research Inc ., London , Ontario , Canada.
authors.forename: Maria
authors.initials: M
authors.lastname: Cernea
mesh_terms: D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D019468:Disease Management; D006801:Humans; D009262:Nails / Q000378:metabolism; D014009:Onychomycosis / Q000188:drug therapy*; D019999:Pharmaceutical Solutions; D014230:Triazoles / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D019999:Pharmaceutical Solutions; D014230:Triazoles; C431707:efinaconazole
keywords: Efinaconazole; Jublia; fungal infection; tinea unguium; toenail