title: Managing medical comorbidities in patients with depression to improve prognosis.
abstract: Medical comorbidities contribute to poor antidepressant response, treatment resistance, and poor outcomes in many patients with depression. Depression can co-occur with thyroid conditions, chronic pain conditions, central nervous system disorders, and more. Inflammatory conditions such as diabetes and obesity are also associated with depression, and the connection between inflammation and depression may lead to testing that could better match patients to specific antidepressant treatment. Interventions for patients with depression and a comorbid medical condition include careful selection of antidepressant therapy as well as psychotherapy and adjunctive agents.
authors.affiliation: Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, 3535 Market St, Philadelphia, PA 19104 thase@mail.med.upenn.edu.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Thase
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D059350:Chronic Pain / Q000453:epidemiology*; D003131:Combined Modality Therapy / Q000379:methods; D015897:Comorbidity; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000628:therapy*; D006801:Humans; D007249:Inflammation / Q000453:epidemiology*; D011379:Prognosis; D011613:Psychotherapy; D013763:Tetrahydrofolates / Q000627:therapeutic use; D013959:Thyroid Diseases / Q000453:epidemiology*
chemical_list: D000928:Antidepressive Agents; D013763:Tetrahydrofolates; C005984:5-methyltetrahydrofolate