title: Diffusion-weighted magnetic resonance imaging in the depiction of gastric cancer: initial experience.
abstract: The aim of the study was to explore the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in the depiction of gastric cancer and to investigate the signal characteristics and apparent diffusion coefficient (ADC) of gastric cancer. An institutional review board-approved protocol was developed for this prospective study. DW-MRI was performed on 101 patients with gastric cancer that was detected by gastroscopy biopsy. The optimal number of excitations (NEX) for DW-MRI was determined, and the signal characteristics of gastric cancer on DW-MRI were analyzed. The ADC of gastric cancer was measured by two experienced radiologists independently, and the reproducibility of measurement was investigated by the Bland-Altman analysis. When DW-MRI was used with four NEXs, areas of gastric cancer showed a good contrast and contrast-to-noise ratio. Four kinds of signal characteristics of gastric cancer were observed on DW-MRI: uniformly high signal, inner high signal, and outer low signal (two-layer type), high-low-high signal (three-layer sandwich type), and mixed type. The mean ADC of gastric cancer measured by two observers was (1.18 ± 0.29) × 10(-3) mm(2)/s and (1.20 ± 0.31) × 10(-3) mm(2)/s respectively, which showed good agreement with Bland-Altman analysis (95% limits of agreement: -0.16 to +0.19 × 10(-3) mm(2)/s). Gastric cancers have various signal characteristics on DW-MRI and the reproducibility of ADC measurement is satisfactory. DW-MRI is helpful in the depiction of gastric cancer.
authors.affiliation: Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No.52 Fu Cheng Road, Hai Dian District, Beijing, 100142, China. terrytang78@163.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No.52 Fu Cheng Road, Hai Dian District, Beijing, 100142, China. sunysabc@163.com.
authors.forename: Ying-Shi
authors.initials: YS
authors.lastname: Sun
authors.affiliation: Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No.52 Fu Cheng Road, Hai Dian District, Beijing, 100142, China.
authors.forename: Zi-Yu
authors.initials: ZY
authors.lastname: Li
authors.affiliation: Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No.52 Fu Cheng Road, Hai Dian District, Beijing, 100142, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Cao
authors.affiliation: Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No.52 Fu Cheng Road, Hai Dian District, Beijing, 100142, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No.52 Fu Cheng Road, Hai Dian District, Beijing, 100142, China.
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Li
authors.affiliation: Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No.52 Fu Cheng Road, Hai Dian District, Beijing, 100142, China.
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D001706:Biopsy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D013274:Stomach Neoplasms / Q000175:diagnosis*
keywords: Apparent diffusion coefficient; Diffusion-weighted imaging; Magnetic resonance imaging; Reproducibility; Stomach neoplasms