title: Mongolians in the Genetic Landscape of Central Asia: Exploring the Genetic Relations among Mongolians and Other World Populations.
abstract: Genetic data on North and Central Asian populations are underrepresented in the literature, especially for autosomal markers. In the present study we used 812 single nucleotide polymorphisms (SNPs) distributed across all the human autosomes and extensively studied at Yale to examine the affinities of two recently collected samples of populations: rural and cosmopolitan Mongolians from Ulaanbaatar and nomadic, Turkic-speaking Tsaatan from Mongolia near the Siberian border. We compare these two populations with each other and with a global set of populations and discuss their relationships to New World populations. Specifically, we analyze data on 521 autosomal loci (single SNPs and multi-SNP haplotypes) studied in 57 populations representing all the major geographical regions of the world. We conclude that these North and Central Asian populations are genetically distinct from all other populations in our study and may be close to the ancestral lineage leading to the New World populations.
authors.affiliation: 1 Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Brissenden
authors.affiliation: 2 Department of Genetics, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Judith R
authors.initials: JR
authors.lastname: Kidd
authors.affiliation: 1 Department of Medicine, University of Toronto, Toronto, Ontario, Canada.|3 Department of Nephrology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
authors.forename: Baigalmaa
authors.initials: B
authors.lastname: Evsanaa
authors.affiliation: 3 Department of Nephrology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
authors.forename: Ariunaa J
authors.initials: AJ
authors.lastname: Togtokh
authors.affiliation: 2 Department of Genetics, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Pakstis
authors.affiliation: 4 Independent scientist, Sharon, Connecticut.
authors.forename: Françoise
authors.initials: F
authors.lastname: Friedlaender
authors.affiliation: 2 Department of Genetics, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Kenneth K
authors.initials: KK
authors.lastname: Kidd
authors.affiliation: 1 Department of Medicine, University of Toronto, Toronto, Ontario, Canada.|5 The Scarborough Hospital, Toronto, Ontario, Canada.
authors.forename: Janet M
authors.initials: JM
authors.lastname: Roscoe
mesh_terms: D001106:Archaeology / Q000379:methods*; D001209:Asia, Central / Q000208:ethnology; D044466:Asian People / Q000235:genetics*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D019143:Evolution, Molecular; D005787:Gene Frequency; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008986:Mongolia; D020641:Polymorphism, Single Nucleotide; D012463:Saliva / Q000737:chemistry
chemical_list: D004247:DNA
keywords: HAPLOTYPE; MONGOLIAN; NATIVE AMERICAN; SNP; TSAATAN