title: A t(11;14)(p13;q11.2) in myelofibrosis following polycythemia vera.
abstract: Chromosomal abnormalities at 14q11, which encodes the T-cell receptor α and δ chain genes, are generally specific for T-cell malignancies, and are rarely reported in other malignancies. We report a novel t(11;14)(p13;q11.2) in a patient with myelofibrosis (MF) following polycythemia vera (PV). This 55-year-old male developed post-PV MF 12 years after the initial diagnosis of PV. He had a normal karyotype at polycythemic disease stage, t(11;14)(p13;q11.2) was newly detected at the time of fibrotic transformation. Therefore, it is likely that this clonal chromosomal abnormality was associated with progression of disease.
authors.affiliation: Department of Laboratory Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea.
authors.forename: Ji Hun
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Laboratory Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea.
authors.forename: Jeong Yeal
authors.initials: JY
authors.lastname: Ahn
authors.affiliation: Department of Laboratory Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea.
authors.forename: Pil Whan
authors.initials: PW
authors.lastname: Park
authors.affiliation: Department of Laboratory Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea.
authors.forename: Yiel Hea
authors.initials: YH
authors.lastname: Seo
authors.affiliation: Department of Laboratory Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea.
authors.forename: Ja Young
authors.initials: JY
authors.lastname: Seo
authors.affiliation: Department of Internal Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea. Electronic address: khkim74@gilhospital.com.
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Kim
mesh_terms: D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000235:genetics* / Q000473:pathology; D055728:Primary Myelofibrosis / Q000235:genetics*; D014178:Translocation, Genetic
keywords: Post-polycythemia vera myelofibrosis (post-PV MF); t(11;14)(p13;q11.2)