title: A D-optimal design to model the performances of dressings and devices for negative pressure wound therapy.
abstract: A D-optimal design was used to identify and model variables that affect the transit time of wound exudate through an illustrative dressing used for negative pressure wound therapy. Many authors have addressed the clinical benefits of negative pressure wound therapy, but limited information is available on how to assess performances of dressings. In this paper, the transit time of wound exudate through a dressing was chosen as a model parameter to show how experimental design (DOE) can be used for this purpose. Results demonstrated that rate of exudate production, temperature and dressing thickness were the variables with the largest impact on transit time. The DOE approach could be used to model other dressing properties, like for example capability of absorbing excess exudate or breathability.
authors.affiliation: Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124, Pisa, Italy. Electronic address: pietro.salvo@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Salvo
authors.affiliation: CSEM SA, Rue Jaquet-Droz 1, 2002 Neuchâtel, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Smajda
authors.affiliation: Wound Healing Research Unit, Department of Dermatology, University of Pisa, Via Roma, 67, 56126 Pisa, Italy. Electronic address: valentinadini74@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Dini
authors.affiliation: Smith & Nephew, Hessle Road 101, Hull, England, UK.
authors.forename: C
authors.initials: C
authors.lastname: Saxby
authors.affiliation: CSEM SA, Rue Jaquet-Droz 1, 2002 Neuchâtel, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Voirin
authors.affiliation: Wound Healing Research Unit, Department of Dermatology, University of Pisa, Via Roma, 67, 56126 Pisa, Italy. Electronic address: m.romanelli@med.unipi.it.
authors.forename: M
authors.initials: M
authors.lastname: Romanelli
authors.affiliation: Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124, Pisa, Italy. Electronic address: fabio.difrancesco@unipi.it.
authors.forename: F
authors.initials: F
authors.lastname: Di Francesco
mesh_terms: D001458:Bandages; D005122:Exudates and Transudates / Q000502:physiology*; D008962:Models, Theoretical; D054843:Negative-Pressure Wound Therapy / Q000295:instrumentation* / Q000379:methods
keywords: Chronic wounds; D-optimal design; Exudate transit time; Negative pressure wound therapy; Wound dressing