title: [EXPRESSION OF GENES, WHICH CONTROL GLUCOSE METABOLISM, IN BLOOD CELLS OF THE OBESE BOYS WITH INSULIN RESISTANCE].
abstract: We studied the expression of genes, which responsible for glucose metabolism, in the blood of obese boys with and without of insulin resistance as well as in normal (control) individuals. It was shown that the expression level of PFKFB3 gene is increased, PFKFB1 and INSIG2--is decreased, but HK2 gene--significantly does not change in the blood cells of obese boys with normal insulin sensitivity as compared to control group. Insulin resistance in obese boys leads to up-regulation of INSIG2 gene expression as well as to down-regulation of PFKFB1, PFKFB3, and HK2 genes in the blood.cells as compared to obese patients with normal insulin sensitivity. Results of this study provide evidence that obesity affects the expression of the subset of glucose metabolism-related genes in the blood cells and that insulin resistance in obesity is associated with changes in the expression level of PFKFB1, PFKFB3, HK2, and INSIG2 genes, which contribute to the development of insulin resistance as well as glucose intolerance.
authors.forename: O V
authors.initials: OV
authors.lastname: Tiazhka
authors.forename: D O
authors.initials: DO
authors.lastname: Minchenko
authors.forename: V V
authors.initials: VV
authors.lastname: Davydov
authors.forename: O S
authors.initials: OS
authors.lastname: Moliavko
authors.forename: O A
authors.initials: OA
authors.lastname: Budreiko
authors.forename: D K
authors.initials: DK
authors.lastname: Kulieshova
authors.forename: O H
authors.initials: OH
authors.lastname: Minchenko
mesh_terms: D000293:Adolescent; D001773:Blood Cells / Q000378:metabolism* / Q000473:pathology; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D005786:Gene Expression Regulation; D005951:Glucose Tolerance Test; D006593:Hexokinase / Q000097:blood / Q000235:genetics*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000235:genetics; D007333:Insulin Resistance / Q000235:genetics*; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood / Q000235:genetics*; D007527:Isoenzymes / Q000097:blood / Q000235:genetics; D008297:Male; D008565:Membrane Proteins / Q000097:blood / Q000235:genetics*; D009765:Obesity / Q000097:blood / Q000235:genetics* / Q000473:pathology; D025481:Phosphofructokinase-2 / Q000097:blood / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D001786:Blood Glucose; C467727:INSIG2 protein, human; D007328:Insulin; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes; D008565:Membrane Proteins; D006593:Hexokinase; C107345:PFKFB3 protein, human; D025481:Phosphofructokinase-2