title: Weight-related and analytical maternal factors in gestational diabetes to predict birth weight and cord markers of diabetic fetopathy.
abstract: OBJECTIVE
  The objective was to determine the value of clinical and analytical maternal factors to predict birth weight and umbilical cord biochemical markers of diabetic fetopathy.
  
  
  METHODS
  Prospective evaluation of gestational diabetes pregnancies (n = 50). Maternal weight-related clinical and analytical factors were collected during pregnancy. After birth, an umbilical cord sample was taken.
  
  
  RESULTS
  Univariate linear regression analysis showed relationship between maternal weight, glycated hemoglobin (HbA1c) and insulin-like growth factor 1 (IGF1) with birth weight percentile. A significant association was found between maternal weight and cord insulin and C-peptide. Maternal HbA1c, leptin and insulin during pregnancy showed a positive linear association to cord leptin, insulin and C-peptide. In multivariate analysis models, final maternal BMI showed an independent positive association with cord C-peptide.
  
  
  CONCLUSIONS
  Maternal weight-related and analytical parameters show diagnostic value to birth weight and cord markers.
authors.affiliation: a High-Risk Pregnancy Unit, Obstetrics & Gynecology Department, Hospital Universitario Quiron Madrid , Spain and.
authors.forename: Jose
authors.initials: J
authors.lastname: Garcia-Flores
authors.affiliation: a High-Risk Pregnancy Unit, Obstetrics & Gynecology Department, Hospital Universitario Quiron Madrid , Spain and.
authors.forename: Mireia
authors.initials: M
authors.lastname: Cruceyra
authors.affiliation: a High-Risk Pregnancy Unit, Obstetrics & Gynecology Department, Hospital Universitario Quiron Madrid , Spain and.
authors.forename: Marina
authors.initials: M
authors.lastname: Cañamares
authors.affiliation: a High-Risk Pregnancy Unit, Obstetrics & Gynecology Department, Hospital Universitario Quiron Madrid , Spain and.
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Garicano
authors.affiliation: a High-Risk Pregnancy Unit, Obstetrics & Gynecology Department, Hospital Universitario Quiron Madrid , Spain and.
authors.forename: Olga
authors.initials: O
authors.lastname: Nieto
authors.affiliation: a High-Risk Pregnancy Unit, Obstetrics & Gynecology Department, Hospital Universitario Quiron Madrid , Spain and.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Espada
authors.affiliation: b Clinical Analysis Department, Hospital Universitario Quiron Madrid , Pozuelo de Alarcon , Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Lopez
authors.affiliation: a High-Risk Pregnancy Unit, Obstetrics & Gynecology Department, Hospital Universitario Quiron Madrid , Spain and.
authors.forename: Ines
authors.initials: I
authors.lastname: Tamarit
authors.affiliation: a High-Risk Pregnancy Unit, Obstetrics & Gynecology Department, Hospital Universitario Quiron Madrid , Spain and.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sainz De La Cuesta
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000502:physiology*; D001835:Body Weight / Q000502:physiology*; D002096:C-Peptide / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005315:Fetal Diseases / Q000097:blood*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D020738:Leptin / Q000097:blood; D011247:Pregnancy
chemical_list: D002096:C-Peptide; D006442:Glycated Hemoglobin; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D020738:Leptin
keywords: Birth weight; C-peptide; IGF1; erythropoietin; ferritin; gestational diabetes; leptin