title: Prognostic impact and potential interaction of EGFR and c-Met in the progression of esophageal squamous cell carcinoma.
abstract: This study is to examine EGFR and c-Met variation in precancerous lesion, early esophageal squamous cell carcinoma (ESCC), and advanced ESCC and to explore their prognostic significance. EGFR and c-Met were detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Of 158 endoscopy resection (ER) specimens, c-Met high expression and FISH positive were 44.9 and 12.6 %, respectively. EGFR high expression and FISH positive were 2.5 and 19.6 %, respectively. Of 84 surgical specimens, c-Met high expression and FISH positive were 50 and 8.3 %, respectively. EGFR high expression and FISH positive were 7.1 and 28.5 %, respectively. A significant correlation was observed between c-Met and EGFR FISH positive both in ER (P < 0.001) and surgical specimens (P = 0.029). Patients with EGFR high expression had poorer disease-free survival (DFS) and overall survival (OS) (P = 0.031 and P = 0.013) in c-Met high-expression group but not in c-Met low-expression group (P = 0.301 and P = 0.439). C-Met FISH positive did not represent a statistically significant adverse prognosis until 24 months later (P = 0.027 and 0.048). EGFR and c-Met might be involved in the tumorigenesis and development of ESCC. EGFR high expression has different prognostic significance in patients with differing c-Met expression status. C-Met FISH positive represent delayed prognostic factor.
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Haixing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Dongxian
authors.initials: D
authors.lastname: Jiang
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Song
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Akesu
authors.initials: A
authors.lastname: Sujie
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Endoscopic Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Yunshi
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China. tan.lijie@zs-hospital.sh.cn.
authors.forename: Lijie
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China. houyingyong@hotmail.com.
authors.forename: Yingyong
authors.initials: Y
authors.lastname: Hou
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C512478:EGFR protein, human; D066246:ErbB Receptors; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met
keywords: EGFR and c-Met; Early and advanced ESCC; Potential interaction; Precancerous lesion; Prognosis
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