title: Alteration of amiloride-sensitive salt taste nerve responses in aldosterone/NaCl-induced hypertensive rats.
abstract: Salt taste sensitivity is related to physiological condition, and declined in hypertensive patients. However, little is known about the mechanism underlying changes in salt taste sensitivity during the development of hypertension. This is largely due to lack of an appropriate animal model which shows the decline of salt taste sensitivity caused by hypertension. Previous studies have suggested that one of main causes of salt-sensitive hypertension is dysfunction of the renin-angiotensin-aldosterone system (RAAS). To examine the involvement of RAAS in modulation of salt taste sensitivity, we utilized aldosterone/NaCl-treated rats as a well-established model of salt-sensitive hypertension caused by RAAS dysfunction. Amount of sodium intake in aldosterone/NaCl-treated rats was higher than that in control rats. In addition to behavioral changes, the amiloride-sensitive salt taste nerve responses in aldosterone/NaCl-treated rats were remarkably lower by approximately 90% than those in the other groups. Moreover, αENaC mRNA expression in the epithelium of circumvallate papillae was significantly low in aldosterone/NaCl-treated rats. Thus, RAAS modulates salt taste system as is case in hypertensive patients. This report is to our knowledge the first to describe an animal model with decline of amiloride-sensitive salt taste nerve responses by RAAS dysfunction-mediated salt-sensitive hypertension.
authors.affiliation: Kansei Science Laboratories, Kao Corporation, 2606 Akabane, Ichikaimachi, Haga, Tochigi 321-3497, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakamoto
authors.affiliation: Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikaimachi, Haga, Tochigi 321-3497, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Fujii
authors.affiliation: Kansei Science Laboratories, Kao Corporation, 2606 Akabane, Ichikaimachi, Haga, Tochigi 321-3497, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Saito
authors.affiliation: Kansei Science Laboratories, Kao Corporation, 2606 Akabane, Ichikaimachi, Haga, Tochigi 321-3497, Japan.
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Kondo
authors.affiliation: Kansei Science Laboratories, Kao Corporation, 2606 Akabane, Ichikaimachi, Haga, Tochigi 321-3497, Japan. Electronic address: oouchi.atsushi@kao.co.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohuchi
mesh_terms: D000450:Aldosterone; D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002814:Chorda Tympani Nerve / Q000187:drug effects* / Q000503:physiopathology; D053503:Epithelial Sodium Channels / Q000378:metabolism; D006973:Hypertension / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D017207:Rats, Sprague-Dawley; D012084:Renin-Angiotensin System / Q000502:physiology*; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*; D013649:Taste / Q000502:physiology*; D013650:Taste Buds / Q000187:drug effects / Q000378:metabolism; D014059:Tongue / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology
chemical_list: D053503:Epithelial Sodium Channels; D017673:Sodium Chloride, Dietary; D000450:Aldosterone; D000584:Amiloride
keywords: Chorda tympani nerve response; ENaC; RAAS; Salt-sensitive hypertension