title: Review of optical coherence tomography based angiography in neuroscience.
abstract: The brain is a complex ecosystem, consisting of multiple layers and tissue compartments. To facilitate the understanding of its function and its response to neurological insults, a fast in vivo imaging tool with a micron-level resolution, which can provide a field of view at a few millimeters, is desirable. Optical coherence tomography (OCT) is a noninvasive method for imaging three-dimensional biological tissues with high resolution ([Formula: see text]) and without a need for contrast agents. Recent development of OCT-based angiography has started to shed some new light on cerebral hemodynamics in neuroscience. We give an overview of the recent developments of OCT-based imaging techniques for neuroscience applications in rodents. We summarize today's technological alternatives for OCT-based angiography for neuroscience and provide a discussion of challenges and opportunities. Moreover, a summary of OCT angiography studies for stroke, traumatic brain injury, and subarachnoid hemorrhage cases on rodents is provided.
authors.affiliation: University of Washington, Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195, United States; University of Washington, Department of Electrical Engineering, 185 Stevens Way, Seattle, Washington 98195, United States.
authors.forename: Utku
authors.initials: U
authors.lastname: Baran
authors.affiliation: University of Washington , Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195, United States.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
keywords: angiography; optical coherence tomography; stroke; traumatic brain injury
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