title: CD30-Negative Cutaneous T-Cell Lymphomas Other than Mycosis Fungoides.
abstract: Cutaneous T-cell lymphomas (CTCLs), other than mycosis fungoides/Sézary syndrome and the group of cutaneous CD30(+) lymphoproliferative disorders, are rare. These include subcutaneous panniculitis-like T-cell lymphoma (SPTCL); extranodal natural killer/T-cell lymphoma, nasal type; primary cutaneous peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS); and rare subtypes of PTCL, NOS. Apart from SPTCL and primary cutaneous CD4-positive small-medium pleomorphic T-cell lymphoma, these lymphomas have in common aggressive clinical behavior and poor prognosis. Differentiation between these different types of CTCL may be difficult and requires integration of histopathologic findings with clinical data and the results of phenotypic and often molecular genetic studies.
authors.affiliation: Department of Dermatology, Leiden University Medical Center, B1-Q-93, PO Box 9600, Leiden 2300 RC, The Netherlands. Electronic address: rein.willemze@planet.nl.
authors.forename: Rein
authors.initials: R
authors.lastname: Willemze
keywords: Adult T-cell leukemia/lymphoma; Cutaneous T-cell lymphoma; Extranodal NK/T-cell lymphoma, nasal type; Primary cutaneous CD4-positive small-medium pleomorphic T-cell lymphoma; Primary cutaneous aggressive epidermotropic CD8(+) cytotoxic T-cell lymphoma; Primary cutaneous gamma-delta T-cell lymphoma; Primary cutaneous peripheral T-cell lymphoma, not otherwise specified; Subcutaneous panniculitis–like T-cell lymphoma