title: Brain Metabolism Correlates of the Free and Cued Selective Reminding Test in Mild Cognitive Impairment.
abstract: Free and Cued Selective Reminding Test (FCSRT) measures immediate and delayed episodic memory and cueing sensitivity and is suitable to detect prodromal Alzheimer's disease (AD). The present study aimed at investigating the segregation effect of FCSRT scores on brain metabolism of memory-related structures, usually affected by AD pathology, in the Mild Cognitive Impairment (MCI) stage. A cohort of forty-eight MCI patients underwent FCSRT and 18F-FDG-PET. Multiple regression analysis showed that Immediate Free Recall correlated with brain metabolism in the bilateral anterior cingulate and delayed free recall with the left anterior cingulate and medial frontal gyrus, whereas semantic cueing sensitivity with the left posterior cingulate. FCSRT in MCI is associated with neuro-functional activity of specific regions of memory-related structures connected to hippocampal formation, such as the cingulate cortex, usually damaged in AD.
authors.affiliation: Department of Neurosciences, University of Parma, Parma, Italy.|Dipartimento di Emergenza-Urgenza e Area Medica Generale e Specialistica, Azienda Ospedaliero-Universitaria, Parma, Italy.|Centre of Cognitive Disorders and Dementia (CDCD), AUSL, Parma, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Caffarra
authors.affiliation: Department of Medical Physic, Azienda Ospedaliero-Universitaria, Parma, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Ghetti
authors.affiliation: Department of Nuclear Medicine Department, Azienda Ospedaliero-Universitaria, Parma, Italy.
authors.forename: Livia
authors.initials: L
authors.lastname: Ruffini
authors.affiliation: Dipartimento di Emergenza-Urgenza e Area Medica Generale e Specialistica, Azienda Ospedaliero-Universitaria, Parma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Spallazzi
authors.affiliation: Department of Neurosciences, University of Parma, Parma, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Spotti
authors.affiliation: Dipartimento di Emergenza-Urgenza e Area Medica Generale e Specialistica, Azienda Ospedaliero-Universitaria, Parma, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Barocco
authors.affiliation: Department of Neurosciences, University of Parma, Parma, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Guzzo
authors.affiliation: Department of Neurosciences, University of Parma, Parma, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Marchi
authors.affiliation: Department of Neurosciences, University of Parma, Parma, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Gardini
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D060825:Cognitive Dysfunction / Q000150:complications* / Q000473:pathology*; D003463:Cues; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D061212:Memory, Episodic; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Alzheimer’s disease; FDG-PET; Free and Cued Selective Reminding Test; medial-temporal structures; mild cognitive impairment