title: Models Predictive of Metabolic Syndrome Components in Obese Pediatric Patients.
abstract: OBJECTIVE
  Components of metabolic syndrome (MetS) are complications caused by abdominal obesity and insulin resistance (IR). Diagnosis of MetS by clinical indicators could help to identify patients at risk of cardiovascular disease and type 2 diabetes. We undertook this study to propose predictive indicators of MetS in obese children and adolescents.
  
  
  METHODS
  A cross-sectional study was carried out. After obtaining informed consent and the registration of the study with an institutional research committee, 172 obese patients from an Obesity Clinic, aged 6-15 years, were included. Variables included were waist circumference (WC), glucose, high-density lipoprotein (HDL), triglycerides (TGL), blood pressure, insulin resistance (by homeostatic model assessment HOMA-index), acanthosis nigricans (AN), uric acid, serum glutamic oxaloacetic transaminase (GOT) and alanine transaminase, and hepatic sonogram. International standards for age and sex variables were used. Multivariate analysis was applied.
  
  
  RESULTS
  Variables predicted components of MetS in children: HOMA-IR (insulin resistance by HOMA index) was increased by 2.4 in hepatic steatosis, by 0.6 for each unit of SUA (serum uric acid), and by 0.009 for every mg/dL of triglycerides. In adolescents, every cm of waist circumference increased systolic blood pressure by 0.6 mmHg, and each unit of SUA increased it by 2.9 mmHg.
  
  
  CONCLUSIONS
  Serum uric acid and waist circumference are useful and accessible variables that can predict an increased risk of cardiovascular disease in obese pediatric patients.
authors.affiliation: Department of Pediatric Emergency, UMAE Pediatric Hospital of the West National Medical Center, IMSS, Guadalajara, Mexico. Electronic address: drarosyortegac@hotmail.com.
authors.forename: Rosa
authors.initials: R
authors.lastname: Ortega-Cortes
authors.affiliation: Biomedical Research Unit, Post-Graduates of Medical Sciences, Medical School of the University of Colima, Mexico.
authors.forename: Xóchitl
authors.initials: X
authors.lastname: Trujillo
authors.affiliation: Department of Pediatric Emergency, UMAE Pediatric Hospital of the West National Medical Center, IMSS, Guadalajara, Mexico.
authors.forename: Erika Fabiola
authors.initials: EF
authors.lastname: Hurtado López
authors.affiliation: Department of Pediatric Endocrinology, UMAE Pediatric Hospital of the National Medical Center West, IMSS, Guadalajara, Mexico.
authors.forename: Ana Laura
authors.initials: AL
authors.lastname: López Beltrán
authors.affiliation: Division of Education and Research in Health, UMAE Pediatric Hospital of the National Medical Center West, IMSS, Guadalajara, Mexico.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Colunga Rodríguez
authors.affiliation: Division of Education and Research in Health, UMAE Pediatric Hospital of the National Medical Center West, IMSS, Guadalajara, Mexico.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Barrera-de Leon
authors.affiliation: Division of Education and Research in Health, UMAE Pediatric Hospital of the National Medical Center West, IMSS, Guadalajara, Mexico.
authors.forename: Alberto
authors.initials: A
authors.lastname: Tlacuilo-Parra
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D002648:Child; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000503:physiopathology; D005234:Fatty Liver; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D056128:Obesity, Abdominal / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008075:Lipoproteins, HDL; D014280:Triglycerides; D014527:Uric Acid
keywords: Insulin resistance; Obesity; Uric acid; Waist circumference