title: Brief Report: Macrophage Activation in HIV-2-Infected Patients Is Less Affected by Antiretroviral Treatment-sCD163 in HIV-1, HIV-2, and HIV-1/2 Dually Infected Patients.
abstract: The course of disease among HIV-2, HIV-1, and HIV-1/2 dually infected patients is different. We investigated the macrophage activation marker soluble CD163 (sCD163) dynamics in 212 HIV-1, HIV-2, and HIV-1/2 dually infected patients. There were no differences in sCD163 levels at baseline or during follow-up without antiretroviral therapy (ART). At follow-up on ART, median sCD163 levels were decreased for HIV-1-infected patients (P < 0.001), but not among HIV-2 (P = 0.093) or HIV-1/2 dually infected patients (P = 0.145). The larger decrease in sCD163 levels among HIV-1-infected patients during ART may indicate an HIV type-dependent differential effect of ART on macrophage activation during HIV infection.
authors.affiliation: *Department of Clinical Immunology, Aarhus University Hospital, Denmark;†Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau;Departments of ‡Infectious Diseases;§Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark;‖Department of Biomedicine, Aarhus University, Denmark;¶National HIV Programme, Ministry of Health, Bissau, Guinea-Bissau; and#GloHAU, Center for Global Health, School of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Bo L
authors.initials: BL
authors.lastname: Hønge
authors.forename: Morten N
authors.initials: MN
authors.lastname: Andersen
authors.forename: Sanne
authors.initials: S
authors.lastname: Jespersen
authors.forename: Candida
authors.initials: C
authors.lastname: Medina
authors.forename: Faustino G
authors.initials: FG
authors.lastname: Correira
authors.forename: Martin R
authors.initials: MR
authors.lastname: Jakobsen
authors.forename: Alex
authors.initials: A
authors.lastname: Laursen
authors.forename: Christian
authors.initials: C
authors.lastname: Erikstrup
authors.forename: Holger J
authors.initials: HJ
authors.lastname: Møller
authors.forename: Christian
authors.initials: C
authors.lastname: Wejse
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006169:Guinea-Bissau; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006801:Humans; D008262:Macrophage Activation / Q000187:drug effects* / Q000276:immunology; D008297:Male; D011956:Receptors, Cell Surface / Q000097:blood*; D019562:Viral Load; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface