title: Strategies to Maximize the Potential of Marine Biomaterials as a Platform for Cell Therapy.
abstract: Marine biopolymers have been explored as a promising cell therapy system for efficient cell delivery and tissue engineering. However, the marine biomaterial-based systems themselves have exhibited limited performance in terms of maintenance of cell viability and functions, promotion of cell proliferation and differentiation as well as cell delivery efficiency. Thus, numerous novel strategies have been devised to improve cell therapy outcomes. The strategies include optimization of physical and biochemical properties, provision of stimuli-responsive functions, and design of platforms for efficient cell delivery and tissue engineering. These approaches have demonstrated substantial improvement of therapeutic outcomes in a variety of research settings. In this review, therefore, research progress made with marine biomaterials as a platform for cell therapy is reported along with current research directions to further advance cell therapies as a tool to cure incurable diseases.
authors.affiliation: Pharmaceutical Formulation Design Laboratory, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea. hm.kim8905@gmail.com.|Bio-Integration Research Center for Nutra-Pharmaceutical Epigenetics, Chung-Ang University, Seoul 156-756, Korea. hm.kim8905@gmail.com.
authors.forename: Hyeongmin
authors.initials: H
authors.lastname: Kim
authors.affiliation: Pharmaceutical Formulation Design Laboratory, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea. jaehwi@cau.ac.kr.|Bio-Integration Research Center for Nutra-Pharmaceutical Epigenetics, Chung-Ang University, Seoul 156-756, Korea. jaehwi@cau.ac.kr.
authors.forename: Jaehwi
authors.initials: J
authors.lastname: Lee
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry* / Q000302:isolation & purification; D001704:Biopolymers / Q000737:chemistry* / Q000302:isolation & purification; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D006801:Humans; D023822:Tissue Engineering / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D001704:Biopolymers
keywords: cell therapy; delivery systems; marine biomaterials; optimization; stimuli-responsive systems; tissue engineering
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