title: Hydrogen sulfide protects against cognitive impairment induced by hepatic ischemia and reperfusion via attenuating neuroinflammation.
abstract: Previously, hepatic ischemia followed by reperfusion (hepatic I/R) has been found to cause cognitive impairment. Hydrogen sulfide (H2S) attenuates hepatectomy induced cognitive deficits and also protects against cognitive dysfunction induced by neurodegenerative diseases. In this study, we aim to determine whether sodium hydrosulfide (NaHS), a H2S donor, could alleviate hepatic I/R-induced cognitive impairment and the underlying mechanisms. Rats were injected intraperitoneally with NaHS (5 mg/kg/d) for 11 days. A segmental hepatic I/R model was established on the fourth day. Cognitive function, proinflammatory cytokines levels, and hippocampal ionized calcium-binding adaptor molecule 1 (Iba1) expression was analyzed. We found hepatic I/R increased proinflammatory cytokines levels in serum and hippocampus, up-regulated Iba1 expression, leading to cognitive impairment in rats. However, treatment with NaHS alleviated hepatic I/R induced these neuroinflammatory changes and effectively improved cognitive function. Thus, NaHS appears to protect against cognitive impairment in rats undergoing hepatic I/R by attenuating neuroinflammation in the hippocampus.
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
authors.forename: Faping
authors.initials: F
authors.lastname: Tu
authors.affiliation: Hepatobiliary Research Institute of North Sichuan Medical College, Nanchong 637000, China.
authors.forename: Jingdong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Wang
authors.affiliation: Hepatobiliary Research Institute of North Sichuan Medical College, Nanchong 637000, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China chuweihua@cpu.edu.cn.
authors.forename: Weihua
authors.initials: W
authors.lastname: Chu
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000032:analysis; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D016207:Cytokines / Q000032:analysis; D004195:Disease Models, Animal; D006624:Hippocampus / Q000473:pathology; D007274:Injections, Intraperitoneal; D007511:Ischemia / Q000150:complications*; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D008840:Microfilament Proteins / Q000032:analysis; D009460:Neurologic Examination; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000150:complications*; D013440:Sulfides / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: C100745:Aif1 protein, rat; D002135:Calcium-Binding Proteins; D016207:Cytokines; D008840:Microfilament Proteins; D018696:Neuroprotective Agents; D013440:Sulfides; C025451:sodium bisulfide
keywords: Hydrogen sulfide; cognition; cytokines; hepatic ischemia and reperfusion; microglia
references.citation: FASEB J. 2002 Nov;16(13):1792-8
references.pmid: 12409322
references.citation: Neurotherapeutics. 2010 Oct;7(4):354-65
references.pmid: 20880500
references.citation: Biochem Biophys Res Commun. 2000 Jan 7;267(1):129-33
references.pmid: 10623586
references.citation: Neuroscience. 2004;124(2):319-26
references.pmid: 14980382
references.citation: Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1193-201
references.pmid: 16428267
references.citation: HPB Surg. 2012;2012:176723
references.pmid: 22693364
references.citation: J Am Geriatr Soc. 2002 Dec;50(12):2041-56
references.pmid: 12473019
references.citation: Exp Physiol. 2005 Sep;90(5):663-70
references.pmid: 15944202
references.citation: J Pharmacol Exp Ther. 1991 Dec;259(3):988-96
references.pmid: 1762091
references.citation: Pharmacol Rep. 2007 Jan-Feb;59(1):4-24
references.pmid: 17377202
references.citation: J Clin Exp Hepatol. 2015 Mar;5(Suppl 1):S21-8
references.pmid: 26041953
references.citation: Prog Neurobiol. 2002 Jul;67(4):259-79
references.pmid: 12207972
references.citation: Anesthesiology. 2007 Mar;106(3):436-43
references.pmid: 17325501
references.citation: Mol Pharmacol. 2007 Mar;71(3):817-25
references.pmid: 17151289
references.citation: J Neuroimmunol. 1993 Sep;47(2):169-76
references.pmid: 8370768
references.citation: J Neuroinflammation. 2012 Aug 17;9:202
references.pmid: 22898621
references.citation: Neuroimmunomodulation. 1998 Sep-Oct;5(5):234-40
references.pmid: 9730691
references.citation: Pharmacol Biochem Behav. 2010 Jul;96(1):52-8
references.pmid: 20399805
references.citation: Shock. 2013 Jan;39(1):3-10
references.pmid: 23143067
references.citation: Nat Protoc. 2006;1(2):848-58
references.pmid: 17406317
references.citation: Brain Res. 2002 Aug 16;946(2):221-31
references.pmid: 12137925
references.citation: Psychoneuroendocrinology. 2007 Sep-Nov;32(8-10):1106-15
references.pmid: 17976923
references.citation: Liver Transpl. 2009 Oct;15(10):1306-14
references.pmid: 19790158
references.citation: Neurochem Res. 2011 Oct;36(10):1840-9
references.pmid: 21603936
references.citation: J Neurochem. 2007 Feb;100(4):1121-8
references.pmid: 17212697
references.citation: Curr Opin Pharmacol. 2006 Apr;6(2):125-9
references.pmid: 16487749
references.citation: Transplant Proc. 2006 Sep;38(7):2203-6
references.pmid: 16980043
references.citation: Neurochem Int. 2009 Jul-Aug;55(1-3):106-12
references.pmid: 19428813
references.citation: J Neurosci. 1996 Feb 1;16(3):1066-71
references.pmid: 8558235
references.citation: Glia. 2010 Jan 1;58(1):103-13
references.pmid: 19544392