title: Time-resolved singlet-oxygen luminescence detection with an efficient and practical semiconductor single-photon detector.
abstract: In clinical applications, such as PhotoDynamic Therapy, direct singlet-oxygen detection through its luminescence in the near-infrared range (1270 nm) has been a challenging task due to its low emission probability and the lack of suitable single-photon detectors. Here, we propose a practical setup based on a negative-feedback avalanche diode detector that is a viable alternative to the current state-of-the art for different clinical scenarios, especially where geometric collection efficiency is limited (e.g. fiber-based systems, confocal microscopy, scanning systems etc.). The proposed setup is characterized with Rose Bengal as a standard photosensitizer and it is used to measure the singlet-oxygen quantum yield of a new set of photosensitizers for site-selective photodynamic therapy.
authors.affiliation: Group of Applied Physics, University of Geneva, Chemin de Pinchat 22, Genève 4, CH-1211, Switzerland.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Boso
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, Genève 4, CH-1211, Switzerland.
authors.forename: Damei
authors.initials: D
authors.lastname: Ke
authors.affiliation: Group of Applied Physics, University of Geneva, Chemin de Pinchat 22, Genève 4, CH-1211, Switzerland.
authors.forename: Boris
authors.initials: B
authors.lastname: Korzh
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, Genève 4, CH-1211, Switzerland.
authors.forename: Jordan
authors.initials: J
authors.lastname: Bouilloux
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, Genève 4, CH-1211, Switzerland.
authors.forename: Norbert
authors.initials: N
authors.lastname: Lange
authors.affiliation: Group of Applied Physics, University of Geneva, Chemin de Pinchat 22, Genève 4, CH-1211, Switzerland.
authors.forename: Hugo
authors.initials: H
authors.lastname: Zbinden
keywords: (030.5260) Photon counting; (170.3880) Medical and biological imaging; (170.5180) Photodynamic therapy; (170.6280) Spectroscopy, fluorescence and luminescence; (170.6920) Time-resolved imaging; (230.5160) Photodetectors; (250.5230) Photoluminescence; (270.5570) Quantum detectors; (350.5130) Photochemistry
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