title: Epigenetic Drugs for Multiple Sclerosis.
abstract: There is increasing evidence that abnormalities in epigenetic mechanisms of gene expression contribute to the development of multiple sclerosis (MS). Advances in epigenetics have given rise to a new class of drugs, epigenetic drugs. Although many classes of epigenetic drugs are being investigated, at present most attention is being paid to two classes of epigenetic drugs: drugs that inhibit DNA methyltransferase (DNMTi) and drugs that inhibit histone deacetylase (HDACi). This paper discusses the potential use of epigenetic drugs in the treatment of MS, focusing on DNMTi and HDACi. Preclinical drug trials of DNMTi and HDACi for the treatment of MS are showing promising results. Epigenetic drugs could improve the clinical management of patients with MS.
authors.affiliation: Department of Pharmacology and Clinical Pharmacology Christian Medical College Vellore India. jpeedi@cmcvellore.ac.in.
authors.forename: Jacob
authors.initials: J
authors.lastname: Peedicayil
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods; D044127:Epigenesis, Genetic / Q000187:drug effects / Q000235:genetics*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics / Q000379:methods / Q000639:trends*
chemical_list: D056572:Histone Deacetylase Inhibitors
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