title: Bone Regenerative Potential of Enamel Matrix Protein in the Circumferential Defect Around a Dental Implant.
abstract: OBJECTIVE
  The aim of this study was to determine the bone regenerative potential of enamel matrix derivative (EMD) in a defect around a dental implant.
  
  
  METHODS
  Five mongrel dogs were used. A circumferential defect was created around osteotomies that had been fabricated to receive titanium implants. The defects were treated with EMD, biphasic calcium phosphate (BCP), a mixture of EMD and BCP (EBCP), or blood coagulum (control).
  
  
  RESULTS
  In general, the amount of new bone formation, the most-coronal level of bone-implant contact, defect fill, and bone-implant contact ratio were greater in the EMD group than in the control group, but the differences did not reach statistical significance. The EBCP group yielded no beneficial effect in new bone formation. Histologically, there was no notable difference in healing pattern between the EMD group and the control, and the EBCP and the BCP group. Few of the specimens in the EMD and EBCP groups exhibited remarkable bone regeneration.
  
  
  CONCLUSIONS
  Neither EMD alone nor a mixture of BCP and EMD enhanced bone healing in a circumferential gap defect around a dental implant.
authors.affiliation: *Clinical Assistant Professor, Department of Periodontology, School of Dentistry, KyungHee University, Seoul, South Korea. †Assistant Professor, Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea. ‡Associate Professor, Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea. §Professor, Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Hyun-Chang
authors.initials: HC
authors.lastname: Lim
authors.forename: Jung-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Ui-Won
authors.initials: UW
authors.lastname: Jung
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi
mesh_terms: D000818:Animals; D000069343:Bone-Implant Interface / Q000502:physiology; D002130:Calcium Phosphates / Q000627:therapeutic use; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D004285:Dogs; D008297:Male; D016348:Osseointegration / Q000187:drug effects* / Q000502:physiology
chemical_list: D002130:Calcium Phosphates; D003746:Dental Enamel Proteins; D015921:Dental Implants; C109069:enamel matrix proteins; C020243:calcium phosphate