title: Survival Differences by Race/Ethnicity and Neighborhood Socioeconomic Status in Adolescents and Young Adults Diagnosed with Non-Hodgkin Lymphoma.
abstract: OBJECTIVE
  Lymphoid malignancies are among the most common cancers diagnosed in adolescents and young adults (AYAs). However, little is known about the factors affecting survival in AYAs with non-Hodgkin lymphoma (NHL). We evaluated if survival differs by race/ethnicity and neighborhood socioeconomic status in AYAs with NHL.
  
  
  METHODS
  AYAs aged 15-39 diagnosed with incident NHL during 1990-2010 at Kaiser Permanente Southern California (KPSC), a large managed care organization, were identified. Demographic information and cancer characteristics were obtained from KPSC's cancer registry. Mortality data were obtained from California and national death files. Patients were followed from NHL diagnosis to 5 years postdiagnosis or 12/31/2012, whichever came first. Multivariable Cox model was used to evaluate the association between race/ethnicity, neighborhood income/education level, and mortality, adjusting for age, gender, stage, year of diagnosis, and histology subtype.
  
  
  RESULTS
  A total of 718 AYAs with NHL were included (mean age at diagnosis: 31 years); 45% were non-Hispanic white, 10% were African American, 36% were Hispanic, and 8% were Asian/Pacific Islander. Overall 5-year mortality was 30%. Compared to non-Hispanic whites, Asians/Pacific Islanders had increased 5-year mortality (hazard ratio=1.95, 95% confidence interval: 0.93-4.07). No significant increase in mortality was found for Hispanics or African Americans. Lower neighborhood income but not education level was associated with worse overall survival.
  
  
  CONCLUSIONS
  A survival disparity for Asians/Pacific Islanders and low-income neighborhoods was observed in AYAs with NHL despite relatively equal access to care. These results call for studies to further understand mechanisms underlying the inferior outcomes among disadvantaged subgroups.
authors.affiliation: 1 Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
authors.forename: Chun
authors.initials: C
authors.lastname: Chao
authors.affiliation: 1 Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
authors.forename: Vicki
authors.initials: V
authors.lastname: Chiu
authors.affiliation: 1 Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
authors.forename: Lanfang
authors.initials: L
authors.lastname: Xu
authors.affiliation: 2 Department of Pediatrics, Los Angeles Medical Center , Kaiser Permanente Southern California, Los Angeles, California.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Cooper
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D001213:Asian / Q000706:statistics & numerical data; D002140:California / Q000453:epidemiology; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000208:ethnology* / Q000401:mortality / Q000473:pathology; D008297:Male; D011379:Prognosis; D012042:Registries; D012923:Social Class; D012959:Socioeconomic Factors; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult
keywords: disparity; lymphoma; race/ethnicity; socioeconomic status; survival