title: Developments in Cardiac Resynchronisation Therapy.
abstract: Cardiac resynchronisation therapy (CRT) is an important therapy for patients with heart failure with a reduced ejection fraction and interventricular conduction delay. Large trials have established the role of CRT in reducing heart failure hospitalisations and improving symptoms, left ventricular (LV) function and mortality. Guidelines from major medical societies are consistent in support of CRT for patients with New York Health Association (NYHA) class II, III and ambulatory class IV heart failure, reduced LV ejection fraction and QRS prolongation, particularly left bundle branch block. The current challenge facing practitioners is to maximise the rate of patients who respond to CRT and the magnitude of that response. Current areas of interest for achieving these goals include tailoring patient selection, individualising LV lead placement and application of new technologies and techniques for CRT delivery.
authors.affiliation: Division of Cardiology, Medical University of South Carolina, Charleston, South Carolina, US.
authors.forename: Geoffrey F
authors.initials: GF
authors.lastname: Lewis
authors.affiliation: Division of Cardiology, Medical University of South Carolina, Charleston, South Carolina, US.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Gold
keywords: Cardiac resynchronisation therapy; LV lead delivery; LV reverse remodelling; cardiac pacemaker; device programming; heart failure; implantable cardioverter/defibrillator; left bundle branch block; left ventricular function
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