title: Membrane dynamics associated with viral infection.
abstract: Viral replication and spreading are fundamental events in the viral life cycle, accounting for the assembly and egression of nascent virions, events that are directly associated with viral pathogenesis in target hosts. These processes occur in cellular compartments that are modified by specialized viral proteins, causing a rearrangement of different cell membranes in infected cells and affecting the ER, mitochondria, Golgi apparatus, vesicles and endosomes, as well as processes such as autophagic membrane flux. In fact, the activation or inhibition of membrane trafficking and other related activities are fundamental to ensure the adequate replication and spreading of certain viruses. In this review, data will be presented that support the key role of membrane dynamics in the viral cycle, especially in terms of the assembly, egression and infection processes. By defining how viruses orchestrate these events it will be possible to understand how they successfully complete their route of infection, establishing viral pathogenesis and provoking disease.
authors.affiliation: Laboratorio de Inmunología Celular y Viral, Unidad de Virología IUETSPC, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna (ULL), Tenerife, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: de Armas-Rillo
authors.affiliation: Laboratorio de Inmunología Celular y Viral, Unidad de Virología IUETSPC, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna (ULL), Tenerife, Spain.
authors.forename: María-Soledad
authors.initials: MS
authors.lastname: Valera
authors.affiliation: Laboratorio de Inmunología Celular y Viral, Unidad de Virología IUETSPC, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna (ULL), Tenerife, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Marrero-Hernández
authors.affiliation: Laboratorio de Inmunología Celular y Viral, Unidad de Virología IUETSPC, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna (ULL), Tenerife, Spain.
authors.forename: Agustín
authors.identifier: http://orcid.org/0000-0002-2585-8703
authors.initials: A
authors.lastname: Valenzuela-Fernández
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism* / Q000821:virology*; D006801:Humans; D019065:Virus Assembly; D014777:Virus Diseases / Q000378:metabolism* / Q000821:virology*; D018406:Virus Physiological Phenomena; D057074:Virus Release; D014779:Virus Replication
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