title: Evaluation of the Efficacy of ME1111 in the Topical Treatment of Dermatophytosis in a Guinea Pig Model.
abstract: The treatment of dermatophytoses, including onychomycosis, has come a long way over the past few decades with the introduction of oral antifungals (e.g., terbinafine and itraconazole). However, with these advancements in oral therapies come several undesirable effects, such as kidney and liver toxicity, along with drug-drug interactions. Consequently, there is a need for new topical agents that are effective against dermatophytosis. ME1111 is a topical antifungal under development. In this study, thein vivoefficacy of ME1111 was compared to that of ciclopirox in the topical treatment of dermatophytosis caused byTrichophyton mentagrophytesusing a guinea pig model. Animals were treated with the topical antifungals starting at 3 days postinfection, with each agent being applied once daily for seven consecutive days. After the treatment period, the clinical and mycological efficacies were evaluated. The data showed that both antifungals demonstrated significant clinical and mycological efficacies; however, ME1111 showed clinical efficacy superior to that of ciclopirox (46.9% and 25.0%, respectively, with aPvalue of <0.001). The potent efficacy of ME1111 could be attributed to its properties, such as low keratin binding.
authors.affiliation: Center for Medical Mycology, Department of Dermatology, Case Western Reserve University School of Medicine, and University Hospitals Case Medical Center, Cleveland, Ohio, USA.
authors.forename: L
authors.initials: L
authors.lastname: Long
authors.affiliation: Center for Medical Mycology, Department of Dermatology, Case Western Reserve University School of Medicine, and University Hospitals Case Medical Center, Cleveland, Ohio, USA.
authors.forename: C
authors.initials: C
authors.lastname: Hager
authors.affiliation: Center for Medical Mycology, Department of Dermatology, Case Western Reserve University School of Medicine, and University Hospitals Case Medical Center, Cleveland, Ohio, USA Mahmoud.Ghannoum@case.edu.
authors.forename: M
authors.initials: M
authors.lastname: Ghannoum
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D000077768:Ciclopirox; D004195:Disease Models, Animal; D006168:Guinea Pigs; D008297:Male; D021261:Parasitic Sensitivity Tests; D010636:Phenols / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D011728:Pyridones / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D014005:Tinea / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome; D014249:Trichophyton / Q000187:drug effects* / Q000254:growth & development
chemical_list: C000611893:2-(3,5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol; D000935:Antifungal Agents; D010636:Phenols; D011720:Pyrazoles; D011728:Pyridones; D000077768:Ciclopirox
references.citation: Int J Dermatol. 2003 Sep;42 Suppl 1:3-9
references.pmid: 12895181
references.citation: Dermatology. 1998;197(2):162-6
references.pmid: 9732167
references.citation: Mycoses. 2009 Jan;52(1):35-43
references.pmid: 18498299
references.citation: Antimicrob Agents Chemother. 2016 Feb;60(2):1035-9
references.pmid: 26643333
references.citation: Am Fam Physician. 2013 Dec 1;88(11):762-70
references.pmid: 24364524
references.citation: Antimicrob Agents Chemother. 2015 Sep;59(9):5154-8
references.pmid: 26055386
references.citation: Antimicrob Agents Chemother. 2016 Feb;60(2):873-80
references.pmid: 26596944
references.citation: Drugs. 2010 Nov 12;70(16):2133-52
references.pmid: 20964457