title: Mesenchymal Tumors of the Prostate.
abstract: Prostatic mesenchymal tumors encompass various benign and malignant neoplasms that may derived from the intrinsic prostatic stroma or from associated elements including muscle, connective tissue, blood vessels, and neural structures. The differential diagnosis of these tumors is broad and encompasses prostatic epithelial processes that demonstrate prominent spindle cell morphology, as well as mesenchymal tumors that secondarily involve the prostate. Careful morphologic examination, clinical history, and judicious use of a limited panel of immunohistochemical markers and molecular tests aid in the proper diagnosis of these lesions. This article provides a structured guide for the analysis and diagnosis of both benign and malignant prostatic mesenchymal lesions and highlights key features that distinguish these entities within the differential diagnosis of prostatic spindle cell lesions.
authors.affiliation: Department of Anatomic Pathology, The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, The Cleveland Clinic, Cleveland, OH, USA; Glickman Urological and Kidney Institute, The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, The Cleveland Clinic, Cleveland, OH, USA; Taussig Cancer Institute, The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, The Cleveland Clinic, Cleveland, OH, USA. Electronic address: hanseld@ccf.org.
authors.forename: Donna E
authors.initials: DE
authors.lastname: Hansel
authors.affiliation: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA; Department of Urology, The Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: George J
authors.initials: GJ
authors.lastname: Netto
authors.affiliation: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Montgomery
authors.affiliation: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA; Department of Urology, The Johns Hopkins Hospital, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Epstein
keywords: Mesenchyme; Neoplasm; Prostate; Spindle cell; Stroma