title: Liposome containing cinnamon oil with antibacterial activity against methicillin-resistant Staphylococcus aureus biofilm.
abstract: The global burden of bacterial disease remains high and is set against a backdrop of increasing antimicrobial resistance. There is a pressing need for highly effective and natural antibacterial agents. In this work, the anti-biofilm effect of cinnamon oil on methicillin-resistant Staphylococcus aureus was evaluated. Then, cinnamon oil was encapsulated in liposomes to enhance its chemical stability. The anti-biofilm activities of the liposome-encapsulated cinnamon oil against MRSA biofilms on stainless steel, gauze, nylon membrane and non-woven fabrics were evaluated by colony forming unit determination. Scanning electron microscopy and laser scanning confocal microscopy analyses were employed to observe the morphological changes in MRSA biofilms treated with the encapsulated cinnamon oil. As a natural and safe spice, the cinnamon oil exhibited a satisfactory antibacterial performance on MRSA and its biofilms. The application of liposomes further improves the stability of antimicrobial agents and extends the action time.
authors.affiliation: a School of Food & Biological Engineering , Jiangsu University , Zhenjiang , PR China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Cui
authors.affiliation: a School of Food & Biological Engineering , Jiangsu University , Zhenjiang , PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: b Department of Bioresource , Hunan Academy of Forestry , Changsha , PR China.
authors.forename: Changzhu
authors.initials: C
authors.lastname: Li
authors.affiliation: c Faculty of Science and Technology , Chiangrai Rajabhat University , Chiangrai , Thailand.
authors.forename: Saritporn
authors.initials: S
authors.lastname: Vittayapadung
authors.affiliation: a School of Food & Biological Engineering , Jiangsu University , Zhenjiang , PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D002935:Cinnamomum zeylanicum; D004866:Equipment Contamination / Q000517:prevention & control*; D004865:Equipment and Supplies, Hospital / Q000382:microbiology; D006801:Humans; D008081:Liposomes / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D008855:Microscopy, Electron, Scanning / Q000379:methods; D009822:Oils, Volatile / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D008081:Liposomes; D009822:Oils, Volatile
keywords: Liposome; MRSA; antibacterial activity; biofilms; cinnamon oil