title: COMT Val158Met polymorphism is associated with blood pressure and lipid levels in general families of Bama longevous area in China.
abstract: To see the possible relationship between COMT Val158Met polymorphism and blood pressure (BP) and serum lipid levels and its putative role in human longevity, we genotyped COMT Val158Met (rs4680) by PCR-RFLP for members from Bama long-lived families (BLF, n = 1538), Bama non-long-lived families (BNLF, n = 600), Pingguo (a county outside Bama region) long-lived families (PLF, n = 538) and Pingguo non-long-lived families (PNLF, n = 403) after anthropometric measures were collected and serum lipid levels were detected. The distribution of genotypes and alleles among four family groups was significantly different (all P < 0.01), with GA/AA genotype and minor allele A presenting more frequently in Bama population than Pingguo Population (P < 0.01). The systolic blood pressure (SBP), pulse pressure (PP), total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) levels of GG genotype carriers were dramatically higher than non-GG carriers in BNLF (P < 0.05); the SBP and PP levels of GG carriers were lower (P < 0.05) while TC, LDL-C level were higher (P < 0.01) than that of non-GG carriers in PLF; no difference in blood pressure and lipids were observed between genotypes in BLF and PNLF (P > 0.05). Correlation analyses revealed that COMT Val158Met was mainly correlated negatively with SBP, diastolic blood pressure (DBP) and LDL-C in BNLF and negatively with TC level in BLF, BNLF and PLF. These data suggest that COMT Val158Met polymorphism may have more impact on the modulation of BP and lipid profiles in the average families than in the long-lived families in Bama region. The association between this SNP and other phenotypes (e.g. cognition) and its roles in the longevity in Bama area thus warrant further investigation.
authors.affiliation: Department of Pathophysiology, Guangxi Medical University Nanning, Guangxi, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ge
authors.affiliation: Department of Cell Biology & Genetics, Guangxi Medical University Nanning , Guangxi, China.
authors.forename: Hua-Yu
authors.initials: HY
authors.lastname: Wu
authors.affiliation: Department of Pathophysiology, Guangxi Medical University Nanning, Guangxi, China.
authors.forename: Shang-Ling
authors.initials: SL
authors.lastname: Pan
authors.affiliation: Department of Pathophysiology, Guangxi Medical University Nanning, Guangxi, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Pathophysiology, Guangxi Medical University Nanning, Guangxi, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.affiliation: Department of Neurology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region Nanning, Guangxi, China.
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Liang
authors.affiliation: Department of Neurology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region Nanning, Guangxi, China.
authors.forename: Guo-Fang
authors.initials: GF
authors.lastname: Pang
authors.affiliation: Department of Neurology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region Nanning, Guangxi, China.
authors.forename: Ze-Ping
authors.initials: ZP
authors.lastname: Lv
authors.affiliation: Department of Neurology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region Nanning, Guangxi, China.
authors.forename: Cai-You
authors.initials: CY
authors.lastname: Hu
authors.affiliation: Department of Pathophysiology, Guangxi Medical University Nanning, Guangxi, China.
authors.forename: Cheng-Wu
authors.initials: CW
authors.lastname: Liu
authors.affiliation: Department of Pathophysiology, Guangxi Medical University Nanning, Guangxi, China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Zhou
authors.affiliation: Department of Pathophysiology, Guangxi Medical University Nanning, Guangxi, China.
authors.forename: Ling-Jin
authors.initials: LJ
authors.lastname: Huang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.
authors.forename: Rui-Xing
authors.initials: RX
authors.lastname: Yin
authors.affiliation: Department of Pathophysiology, Guangxi Medical University Nanning, Guangxi, China.
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Peng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002681:China; D005190:Family; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D008055:Lipids; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
keywords: COMT; blood lipid; blood pressure; longevity
references.citation: Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Feb;23(1):5-10
references.pmid: 12015100
references.citation: J Neurosci. 2004 Jun 9;24(23):5331-5
references.pmid: 15190105
references.citation: Metabolism. 2008 May;57(5):708-11
references.pmid: 18442637
references.citation: Int J Mol Med. 2009 Aug;24(2):233-46
references.pmid: 19578796
references.citation: Neurosci Biobehav Rev. 2006;30(6):791-807
references.pmid: 16901542
references.citation: Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6917-22
references.pmid: 11381111
references.citation: J Nutr Biochem. 2012 Mar;23(3):272-7
references.pmid: 21530215
references.citation: Epigenomics. 2012 Jun;4(3):261-8
references.pmid: 22690662
references.citation: Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1416-20
references.pmid: 1847521
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2011 Sep;156B(6):651-60
references.pmid: 21656904
references.citation: Kidney Blood Press Res. 2006;29(5):312-20
references.pmid: 17106209
references.citation: Psychopharmacology (Berl). 2014 May;231(10):2211-8
references.pmid: 24448899
references.citation: Front Aging Neurosci. 2010 Nov 05;2:146
references.pmid: 21119769
references.citation: Circulation. 2002 Jul 23;106(4):460-5
references.pmid: 12135946
references.citation: Am J Hum Genet. 2004 Nov;75(5):807-21
references.pmid: 15457404
references.citation: J Hypertens. 2003 Dec;21(12):2365-74
references.pmid: 14654758
references.citation: Eur J Cardiovasc Prev Rehabil. 2006 Dec;13(6):977-84
references.pmid: 17143131
references.citation: Pharmacogenomics J. 2005;5(6):346-51
references.pmid: 16130011
references.citation: Am J Hypertens. 2007 Jan;20(1):21-6
references.pmid: 17198907
references.citation: Front Aging Neurosci. 2010 Nov 02;2:143
references.pmid: 21103005
references.citation: J Neurol Neurosurg Psychiatry. 2013 Jun;84(6):666-73
references.pmid: 23408064
references.citation: Am J Hypertens. 2011 Sep;24(9):1022-6
references.pmid: 21776034
references.citation: Pharmacogenetics. 1996 Jun;6(3):243-50
references.pmid: 8807664
references.citation: DNA Cell Biol. 2011 Aug;30(8):585-95
references.pmid: 21438753
references.citation: Lipids Health Dis. 2012;11:177
references.pmid: 23273182
references.citation: Neuropsychopharmacology. 2007 May;32(5):1011-20
references.pmid: 17063156
references.citation: J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1153-60
references.pmid: 22496539
references.citation: Mov Disord. 2005 Jan;20(1):69-72
references.pmid: 15390046
references.citation: Hum Reprod. 2003 Feb;18(2):262-6
references.pmid: 12571159
references.citation: BMC Neurosci. 2009;10:125
references.pmid: 19793392
references.citation: Biochem Biophys Res Commun. 2004 Jan 16;313(3):647-53
references.pmid: 14697241
references.citation: Genes Brain Behav. 2009 Feb;8(1):36-42
references.pmid: 19076243