title: Serum uric acid levels in patients with myasthenia gravis are inversely correlated with disability.
abstract: Uric acid (UA), the final product of purine metabolism, has been reported to be reduced in patients with various neurological disorders and is considered to be a possible indicator for monitoring the disability and progression of multiple sclerosis. However, it remains unclear whether there is a close relationship between UA and myasthenia gravis (MG), or whether UA is primarily deficient or secondarily reduced because of its peroxynitrite scavenging activity. We investigated the correlation between serum UA levels and the clinical characteristics of MG. We assessed 338 serum UA levels obtained in 135 patients with MG, 47 patients with multiple sclerosis, and 156 healthy controls. In addition, we compared serum UA levels when MG patients were stratified according to disease activity and classifications performed by the Myasthenia Gravis Foundation of America, age of onset, duration, and thymus histology (by means of MRI or computed tomography). MG patients had significantly lower serum UA levels than the controls (P<0.001). Moreover, UA levels in patients with MG were inversely correlated with disease activity and disease progression (P=0.013). However, UA levels did not correlate significantly with disease duration, age of onset, and thymus histology. Our findings suggest that serum level of UA was reduced in patients with MG and serum UA might be considered a surrogate biomarker of MG disability and progression.
authors.affiliation: Departments of aNeurology bGastroenterology cSurgical Oncology dLaboratory of Internal Medicine, the First Affiliated Hospital of Wenzhou Medical University eSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China.
authors.forename: Dehao
authors.initials: D
authors.lastname: Yang
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Weng
authors.forename: Haihua
authors.initials: H
authors.lastname: Lin
authors.forename: Feiyan
authors.initials: F
authors.lastname: Xie
authors.forename: Fang
authors.initials: F
authors.lastname: Yin
authors.forename: Kangliang
authors.initials: K
authors.lastname: Lou
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhou
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Han
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
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