title: Rationale for intraoperative radiotherapy in glioblastoma.
abstract: Glioblastoma is the most common and aggressive adult primary brain cancer. Despite multimodal therapy, it is associated with a survival of less than two years. Greater than 85% of recurrences occur within the original area of surgery and radiotherapy, suggesting a potential for improved local treatments. In addition to cancer cell invasion beyond surgical margins, a plethora of postinjury pro-proliferative stimuli are released from local healing brain, which both protect and nourish remaining cancer cells. This review compiles preclinical and clinical evidence for a dedicated treatment of both residual cancer cells and regional microenvironment using intraoperative radiotherapy (IORT).
authors.affiliation: Department of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany - frank.giordano@umm.de.
authors.forename: Frank A
authors.initials: FA
authors.lastname: Giordano
authors.forename: Frederik
authors.initials: F
authors.lastname: Wenz
authors.forename: Kevin
authors.initials: K
authors.lastname: Petrecca
mesh_terms: D001932:Brain Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D005909:Glioblastoma / Q000628:therapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D018365:Neoplasm, Residual / Q000628:therapy*; D011878:Radiotherapy