title: Mouse Models of Breast Cancer: Platforms for Discovering Precision Imaging Diagnostics and Future Cancer Medicine.
abstract: Representing an enormous health care and socioeconomic challenge, breast cancer is the second most common cancer in the world and the second most common cause of cancer-related death. Although many of the challenges associated with preventing, treating, and ultimately curing breast cancer are addressable in the laboratory, successful translation of groundbreaking research to clinical populations remains an important barrier. Particularly when compared with research on other types of solid tumors, breast cancer research is hampered by a lack of tractable in vivo model systems that accurately recapitulate the relevant clinical features of the disease. A primary objective of this article was to provide a generalizable overview of the types of in vivo model systems, with an emphasis primarily on murine models, that are widely deployed in preclinical breast cancer research. Major opportunities to advance precision cancer medicine facilitated by molecular imaging of preclinical breast cancer models are discussed.
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee Vanderbilt-Ingram Cancer Center, Nashville, Tennessee Vanderbilt University Institute of Imaging Science, Nashville, Tennessee; and Vanderbilt Center for Molecular Probes, Nashville, Tennessee henry.c.manning@vanderbilt.edu.
authors.forename: H Charles
authors.initials: HC
authors.lastname: Manning
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee Vanderbilt University Institute of Imaging Science, Nashville, Tennessee; and Vanderbilt Center for Molecular Probes, Nashville, Tennessee.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Buck
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Cook
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy*; D051379:Mice; D057054:Molecular Imaging / Q000639:trends*; D009368:Neoplasm Transplantation; D057285:Precision Medicine; D011877:Radionuclide Imaging
keywords: animal imaging; breast cancer; coclinical trials; molecular imaging; mouse models; precision medicine
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