title: Distinct Reward Properties are Encoded via Corticostriatal Interactions.
abstract: The striatum serves as a critical brain region for reward processing. Yet, understanding the link between striatum and reward presents a challenge because rewards are composed of multiple properties. Notably, affective properties modulate emotion while informative properties help obtain future rewards. We approached this problem by emphasizing affective and informative reward properties within two independent guessing games. We found that both reward properties evoked activation within the nucleus accumbens, a subregion of the striatum. Striatal responses to informative, but not affective, reward properties predicted subsequent utilization of information for obtaining monetary reward. We hypothesized that activation of the striatum may be necessary but not sufficient to encode distinct reward properties. To investigate this possibility, we examined whether affective and informative reward properties were differentially encoded in corticostriatal interactions. Strikingly, we found that the striatum exhibited dissociable connectivity patterns with the ventrolateral prefrontal cortex, with increasing connectivity for affective reward properties and decreasing connectivity for informative reward properties. Our results demonstrate that affective and informative reward properties are encoded via corticostriatal interactions. These findings highlight how corticostriatal systems contribute to reward processing, potentially advancing models linking striatal activation to behavior.
authors.affiliation: Department of Psychology, Rutgers University, Newark, NJ 07102, USA.
authors.forename: David V
authors.initials: DV
authors.lastname: Smith
authors.affiliation: Department of Psychology, Rutgers University, Newark, NJ 07102, USA.
authors.forename: Anastasia E
authors.initials: AE
authors.lastname: Rigney
authors.affiliation: Department of Psychology, Rutgers University, Newark, NJ 07102, USA.
authors.forename: Mauricio R
authors.initials: MR
authors.lastname: Delgado
mesh_terms: D000293:Adolescent; D000328:Adult; D032882:Comprehension / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008959:Models, Neurological; D009714:Nucleus Accumbens / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D012201:Reward
references.citation: J Neurosci. 2015 Mar 4;35(9):3865-78
references.pmid: 25740516
references.citation: Neuroimage. 2012 Jun;61(2):407-26
references.pmid: 22245638
references.citation: Cogn Affect Behav Neurosci. 2012 Jun;12(2):361-72
references.pmid: 22194237
references.citation: PLoS One. 2010;5(12):e15710
references.pmid: 21187930
references.citation: J Cogn Neurosci. 2014 May;26(5):1075-84
references.pmid: 24345173
references.citation: J Neurosci. 2012 Sep 26;32(39):13543-54
references.pmid: 23015444
references.citation: J Neurosci. 2010 Feb 17;30(7):2490-5
references.pmid: 20164333
references.citation: J Neurosci. 2012 Jan 4;32(1):215-22
references.pmid: 22219283
references.citation: Science. 2009 Jul 17;325(5938):284-8
references.pmid: 19608908
references.citation: Curr Dir Psychol Sci. 2013 Jun 1;22(3):244-249
references.pmid: 24748727
references.citation: J Neurophysiol. 2000 Dec;84(6):3072-7
references.pmid: 11110834
references.citation: Nat Neurosci. 2001 Jan;4(1):95-102
references.pmid: 11135651
references.citation: Hum Brain Mapp. 2015 Jul;36(7):2743-55
references.pmid: 25858445
references.citation: Neuroimage. 2004;23 Suppl 1:S208-19
references.pmid: 15501092
references.citation: Cereb Cortex. 2001 Jul;11(7):606-18
references.pmid: 11415963
references.citation: Neuropsychopharmacology. 2010 Jan;35(1):4-26
references.pmid: 19812543
references.citation: Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17302-7
references.pmid: 21987799
references.citation: Science. 2004 Apr 16;304(5669):452-4
references.pmid: 15087550
references.citation: J Neurosci. 2009 Oct 28;29(43):13465-72
references.pmid: 19864559
references.citation: Front Psychol. 2015 Jul 22;6:1026
references.pmid: 26257684
references.citation: Curr Opin Neurobiol. 2012 Dec;22(6):1027-38
references.pmid: 22766486
references.citation: Trends Cogn Sci. 2004 Jun;8(6):261-5
references.pmid: 15165551
references.citation: Neuroimage. 2014 May 1;91:412-9
references.pmid: 24412399
references.citation: Nat Neurosci. 2012 Jul;15(7):1040-6
references.pmid: 22660479
references.citation: Neuroimage. 2012 Jul 16;61(4):1277-86
references.pmid: 22484411
references.citation: Neuroimage. 2003 Aug;19(4):1273-302
references.pmid: 12948688
references.citation: Nat Neurosci. 2006 Aug;9(8):1007-8
references.pmid: 16819523
references.citation: Am J Psychiatry. 2009 Jun;166(6):702-10
references.pmid: 19411368
references.citation: Neuroimage. 2010 Feb 1;49(3):2163-77
references.pmid: 19896537
references.citation: Neuroimage. 2012 Aug 15;62(2):791-800
references.pmid: 22023741
references.citation: Front Psychol. 2010 Sep 07;1:36
references.pmid: 21887145
references.citation: Trends Cogn Sci. 2011 Oct;15(10):483-506
references.pmid: 21908230
references.citation: Science. 2008 Feb 29;319(5867):1264-7
references.pmid: 18309087
references.citation: Ann N Y Acad Sci. 2011 Apr;1224:40-62
references.pmid: 21486295
references.citation: J Neurosci. 2012 Apr 18;32(16):5549-52
references.pmid: 22514316
references.citation: J Neurosci. 2014 Jul 16;34(29):9497-505
references.pmid: 25031393
references.citation: Neuron. 2015 Feb 4;85(3):602-14
references.pmid: 25619657
references.citation: Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4285-9
references.pmid: 22371590
references.citation: J Neurosci. 2013 Feb 20;33(8):3602-11
references.pmid: 23426687
references.citation: Soc Cogn Affect Neurosci. 2014 Dec;9(12):2017-25
references.pmid: 24493836
references.citation: Neuroimage. 1997 Oct;6(3):218-29
references.pmid: 9344826
references.citation: Arch Gen Psychiatry. 2012 Feb;69(2):129-38
references.pmid: 22310503
references.citation: Neuroimage. 2011 Sep 15;58(2):588-94
references.pmid: 21757015
references.citation: Annu Rev Psychol. 2006;57:87-115
references.pmid: 16318590
references.citation: J Neurosci. 2012 Nov 14;32(46):16521-9
references.pmid: 23152634
references.citation: Neuroimage. 2003 Oct;20(2):1052-63
references.pmid: 14568475
references.citation: Eur J Neurosci. 2014 Jun;39(11):2014-26
references.pmid: 24863104
references.citation: J Neurosci. 2014 Jan 15;34(3):932-40
references.pmid: 24431451
references.citation: Neuroimage. 2007 Dec;38(4):666-8
references.pmid: 17976583
references.citation: Soc Neurosci. 2015;10(1):35-45
references.pmid: 25074501
references.citation: Neuroimage. 2005 Jul 1;26(3):839-51
references.pmid: 15955494
references.citation: Neuroimage. 2014 Oct 15;100:580-9
references.pmid: 24979343
references.citation: Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7209-14
references.pmid: 19357304
references.citation: Science. 2006 Nov 24;314(5803):1311-4
references.pmid: 17124325
references.citation: Emotion. 2014 Aug;14(4):646-50
references.pmid: 24866522
references.citation: J Cogn Neurosci. 2006 Jun;18(6):1029-43
references.pmid: 16839308
references.citation: Neuroimage. 2005 Apr 15;25(3):653-60
references.pmid: 15808966
references.citation: J Neurosci. 2014 May 7;34(19):6573-82
references.pmid: 24806682