title: Eric Davidson: Steps to a gene regulatory network for development.
abstract: Eric Harris Davidson was a unique and creative intellectual force who grappled with the diversity of developmental processes used by animal embryos and wrestled them into an intelligible set of principles, then spent his life translating these process elements into molecularly definable terms through the architecture of gene regulatory networks. He took speculative risks in his theoretical writing but ran a highly organized, rigorous experimental program that yielded an unprecedentedly full characterization of a developing organism. His writings created logical order and a framework for mechanism from the complex phenomena at the heart of advanced multicellular organism development. This is a reminiscence of intellectual currents in his work as observed by the author through the last 30-35 years of Davidson's life.
authors.affiliation: Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: evroth@its.caltech.edu.
authors.forename: Ellen V
authors.initials: EV
authors.lastname: Rothenberg
mesh_terms: D000818:Animals; D003585:Cell Biology / Q000266:history*; D019070:Cell Lineage; D015509:Developmental Biology / Q000266:history*; D053263:Gene Regulatory Networks; D049673:History, 20th Century; D049674:History, 21st Century; D012617:Sea Urchins / Q000196:embryology / Q000235:genetics
references.citation: J Exp Zool. 1999 Aug 15;285(2):104-15
references.pmid: 10440721
references.citation: Development. 1997 Dec;124(23):4717-27
references.pmid: 9428408
references.citation: Science. 1969 Jul 25;165(3891):349-57
references.pmid: 5789433
references.citation: Science. 1998 Mar 20;279(5358):1896-902
references.pmid: 9506933
references.citation: Development. 1996 Dec;122(12):4045-56
references.pmid: 9012524
references.citation: Development. 1995 Oct;121(10):3215-22
references.pmid: 7588056
references.citation: Dev Biol. 2012 Apr 15;364(2):259-67
references.pmid: 22509525
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3930-5
references.pmid: 20142491
references.citation: Bioessays. 1997 Jul;19(7):623-31
references.pmid: 9230695
references.citation: Development. 1990 Mar;108(3):365-89
references.pmid: 2187672
references.citation: Cell. 1975 Mar;4(3):217-38
references.pmid: 1122554
references.citation: Development. 1998 Apr;125(8):1381-95
references.pmid: 9502720
references.citation: Nature. 2010 Dec 16;468(7326):911-20
references.pmid: 21164479
references.citation: Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4457-62
references.pmid: 10781044
references.citation: J Mol Biol. 1961 Jun;3:318-56
references.pmid: 13718526
references.citation: Dev Biol. 2007 Oct 15;310(2):187-95
references.pmid: 17822690
references.citation: Semin Cell Dev Biol. 1997 Aug;8(4):359-65
references.pmid: 15001074
references.citation: Dev Biol. 2003 Jun 1;258(1):32-43
references.pmid: 12781680
references.citation: Development. 1996 Jan;122(1):333-48
references.pmid: 8565846
references.citation: Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9514-8
references.pmid: 10920195
references.citation: Bioessays. 2002 Dec;24(12):1118-29
references.pmid: 12447977
references.citation: Development. 1996 Apr;122(4):1069-82
references.pmid: 8620834
references.citation: Methods Cell Biol. 2004;74:775-94
references.pmid: 15575631
references.citation: Nat Rev Genet. 2009 Feb;10(2):141-8
references.pmid: 19139764
references.citation: Int J Dev Biol. 2009;53(5-6):707-16
references.pmid: 19378258
references.citation: Dev Biol. 1996 Feb 25;174(1):43-54
references.pmid: 8626020
references.citation: Cell. 1976 Apr;7(4):487-505
references.pmid: 986248
references.citation: Dev Biol. 2006 Dec 1;300(1):108-20
references.pmid: 16997293
references.citation: Dev Biol. 1983 Nov;100(1):64-119
references.pmid: 6684600
references.citation: Science. 2006 Feb 10;311(5762):796-800
references.pmid: 16469913
references.citation: Curr Opin Genet Dev. 2004 Aug;14(4):351-60
references.pmid: 15261650
references.citation: Science. 2006 Nov 10;314(5801):952-6
references.pmid: 17095692
references.citation: Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4954-9
references.pmid: 15788531
references.citation: Gene. 2007 Dec 30;406(1-2):1-7
references.pmid: 17550788
references.citation: Nature. 2011 Jun 30;474(7353):635-9
references.pmid: 21623371
references.citation: Immunity. 1997 Jan;6(1):1-11
references.pmid: 9052832
references.citation: Proc Natl Acad Sci U S A. 1984 Dec;81(23):7490-4
references.pmid: 6594699
references.citation: Dev Biol. 2006 Sep 15;297(2):587-602
references.pmid: 16925988
references.citation: Development. 1996 Jan;122(1):205-14
references.pmid: 8565831
references.citation: Dev Biol. 2002 Jun 1;246(1):2-13
references.pmid: 12027430
references.citation: Genes Dev. 1988 Sep;2(9):1074-88
references.pmid: 3192074
references.citation: C R Biol. 2005 Jun;328(6):514-20
references.pmid: 15999435
references.citation: J Mol Biol. 1963 Apr;6:306-29
references.pmid: 13936070
references.citation: Science. 2006 Nov 10;314(5801):941-52
references.pmid: 17095691
references.citation: Dev Biol. 2006 Dec 1;300(1):90-107
references.pmid: 17054934
references.citation: Cold Spring Harb Symp Quant Biol. 2009;74:65-80
references.pmid: 20375317
references.citation: EMBO J. 1992 Nov;11(11):4047-57
references.pmid: 1327756
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12383-8
references.pmid: 17636127
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20063-6
references.pmid: 19104053
references.citation: Development. 1991 Sep;113(1):1-26
references.pmid: 1684931
references.citation: Nucleic Acids Res. 2009 Jan;37(Database issue):D750-4
references.pmid: 19010966
references.citation: Proc Natl Acad Sci U S A. 1987 Jan;84(1):151-5
references.pmid: 3467346
references.citation: Genome Res. 2012 Oct;22(10):2079-87
references.pmid: 22709795
references.citation: Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13356-61
references.pmid: 14595011
references.citation: Dev Biol. 2009 Jan 15;325(2):317-28
references.pmid: 19028486
references.citation: Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4936-42
references.pmid: 15788537
references.citation: Dev Biol. 2006 Dec 1;300(1):74-89
references.pmid: 17055477
references.citation: Dev Biol. 2000 Mar 1;219(1):1-17
references.pmid: 10677251
references.citation: Science. 2004 Jul 9;305(5681):218-22
references.pmid: 15178752
references.citation: Science. 2007 Mar 16;315(5818):1510-1
references.pmid: 17363653
references.citation: Development. 1989 Mar;105(3):421-45
references.pmid: 2693035
references.citation: Mech Dev. 1994 Aug;47(2):165-86
references.pmid: 7811639
references.citation: J Comput Biol. 2013 Jun;20(6):419-23
references.pmid: 23614576
references.citation: Cell. 2011 Mar 18;144(6):970-85
references.pmid: 21414487
references.citation: Dev Biol. 2006 Dec 1;300(1):49-62
references.pmid: 17081512
references.citation: Gene Expr Patterns. 2007 Jan;7(1-2):1-7
references.pmid: 16798107
references.citation: Genes Dev. 1987 Mar;1(1):75-85
references.pmid: 2448185
references.citation: FEBS Lett. 2009 Dec 17;583(24):3948-58
references.pmid: 19932099
references.citation: Development. 1997 May;124(10):1851-64
references.pmid: 9169833
references.citation: Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9371-6
references.pmid: 12883007
references.citation: Dev Biol. 1993 Dec;160(2):369-76
references.pmid: 8253270
references.citation: Proc Natl Acad Sci U S A. 1967 Feb;57(2):306-13
references.pmid: 16591470
references.citation: Genes Dev. 1988 Jan;2(1):1-12
references.pmid: 3162723
references.citation: EMBO J. 1989 Apr;8(4):1205-12
references.pmid: 2743979
references.citation: Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2989-93
references.pmid: 7708761
references.citation: Dev Biol. 2002 Jun 1;246(1):86-102
references.pmid: 12027436
references.citation: Development. 1999 Jan;126(2):345-57
references.pmid: 9847248
references.citation: Dev Biol. 2002 Jun 1;246(1):209-28
references.pmid: 12027443
references.citation: Dev Biol. 2002 Aug 1;248(1):182-96
references.pmid: 12142030
references.citation: Methods Mol Biol. 2014;1128:295-310
references.pmid: 24567223
references.citation: Curr Opin Genet Dev. 2009 Dec;19(6):535-40
references.pmid: 19913405
references.citation: Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16434-42
references.pmid: 22927416
references.citation: Dev Biol. 2000 Dec 15;228(2):270-86
references.pmid: 11112329
references.citation: Cold Spring Harb Symp Quant Biol. 1974;38:857-68
references.pmid: 4545512
references.citation: Science. 2006 Jun 16;312(5780):1644-6
references.pmid: 16778054
references.citation: Q Rev Biol. 1971 Jun;46(2):111-38
references.pmid: 5160087
references.citation: Dev Biol. 2010 Apr 15;340(2):188-99
references.pmid: 19895806
references.citation: Dev Biol. 2002 Jun 1;246(1):162-90
references.pmid: 12027441
references.citation: Development. 1990 Sep;110(1):41-50
references.pmid: 2081469
references.citation: PLoS One. 2012;7(4):e35934
references.pmid: 22563420
references.citation: Cell. 1980 Jan;19(1):1-11
references.pmid: 6444544
references.citation: Dev Biol. 2002 Jun 1;246(1):191-208
references.pmid: 12027442
references.citation: Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4430-3
references.pmid: 10781037
references.citation: Science. 2002 Mar 1;295(5560):1669-78
references.pmid: 11872831
references.citation: Dev Biol. 2005 Jul 1;283(1):1-16
references.pmid: 15907831
references.citation: Dev Biol. 1990 Jan;137(1):77-85
references.pmid: 2295368
references.citation: Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):5955-62
references.pmid: 18413610
references.citation: Development. 1989 Aug;106(4):641-7
references.pmid: 2562659
references.citation: Dev Biol. 2014 Jan 15;385(2):160-7
references.pmid: 24291147
references.citation: Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1475-80
references.pmid: 12578984
references.citation: Methods Cell Biol. 2004;74:733-57
references.pmid: 15575629
references.citation: Curr Opin Biotechnol. 2007 Aug;18(4):351-4
references.pmid: 17689240
references.citation: Cell. 1975 Jul;5(3):291-9
references.pmid: 1170956
references.citation: Dev Biol. 2002 Jun 1;246(1):132-47
references.pmid: 12027439
references.citation: Development. 1995 Apr;121(4):1111-22
references.pmid: 7743924
references.citation: Science. 1993 Feb 19;259(5098):1134-8
references.pmid: 8438164
references.citation: Cell. 1977 Mar;10(3):415-32
references.pmid: 844101
references.citation: Perspect Biol Med. 2015 Spring;58(2):165-81
references.pmid: 26750600