title: Resveratrol analogue 4,4'-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis.
abstract: We investigated the preventive effects of resveratrol analogue 4,4'-dihydroxy-trans-stilbene (DHS) on cancer invasion and metastasis. Two different in vivo approaches of mouse and zebrafish lung cancer invasion models were employed in our study. The in vitro results showed that DHS displays potent inhibition on anchorage-dependent or -independent cell growth of LLC cells, leading to impairment of the cell cycle progression with reduction of cell numbers arresting at the G1 phase, an evident accumulation of pre-G1 events correlated with apoptotic behaviour. In addition, DHS induces a marked inhibition of LLC cell migration and matrigel invasion. In a murine lung cancer model, tumour volume, cell proliferation, and tumour angiogenesis were significantly inhibited by DHS. Importantly, liver metastatic lesions were significantly reduced in DHS-treated mice. Similarly, DHS significantly inhibits lung cancer cell dissemination, invasion and metastasis in a zebrafish tumour model. These findings demonstrate that DHS could potentially be developed as a novel therapeutic agent for treatment of cancer and metastasis.
authors.affiliation: Department of Molecular Medicine, Immunology and General Pathology Unit, University of Pavia, Pavia, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Savio
authors.affiliation: Department of Molecular Medicine, Immunology and General Pathology Unit, University of Pavia, Pavia, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Ferraro
authors.affiliation: Department of Molecular Medicine, Immunology and General Pathology Unit, University of Pavia, Pavia, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Maccario
authors.affiliation: Department of Biology and Biotechnology, Comparative Anatomy and Citology Laboratory, University of Pavia, Pavia, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Vaccarone
authors.affiliation: Department of Microbiology, Tumour and Cell Biology, Karolinska Institute, Stockholm, Sweden.|Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
authors.forename: Lasse D
authors.initials: LD
authors.lastname: Jensen
authors.affiliation: Centro Grandi Strumenti, University of Pavia, Pavia, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Corana
authors.affiliation: Centro Grandi Strumenti, University of Pavia, Pavia, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Mannucci
authors.affiliation: Department of Molecular Medicine, Immunology and General Pathology Unit, University of Pavia, Pavia, Italy.
authors.forename: Livia
authors.initials: L
authors.lastname: Bianchi
authors.affiliation: Department of Microbiology, Tumour and Cell Biology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Yihai
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Molecular Medicine, Immunology and General Pathology Unit, University of Pavia, Pavia, Italy.
authors.forename: Lucia Anna
authors.initials: LA
authors.lastname: Stivala
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009361:Neoplasm Invasiveness; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D013267:Stilbenes; C010118:4,4'-dihydroxystilbene; D000077185:Resveratrol
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