title: Role of microRNA 21 in diabetes and associated/related diseases.
abstract: Diabetes mellitus (DM) is a disease related to metabolic disorder and becoming an epidemic in developing countries. Current treatments for DM include modified lifestyle practice, obesity treatment, oral hypoglycemic agents, and insulin sensitizers, yet no cure is available in sight for the disease, despite it requires new insight into the molecular and pathophysiology. MicroRNAs (miRNAs) are small noncoding RNAs considered as of greater biological importance and controls molecular signaling pathways in diabetic pathogenesis. The microRNA 21 is an important microRNA frequently upregulated in all types of diseases suggesting that it plays an important role in cell proliferation, and apoptosis. The present mini review highlights the recent investigations related to the importance of miR-21 in different types of DM based on the up-to-date reports.
authors.affiliation: Stem Cell Division, Cryovault Biotech Pvt Ltd, Bangalore 560016, India. Electronic address: duraimku@gmail.com.
authors.forename: Durairaj
authors.initials: D
authors.lastname: Sekar
authors.affiliation: Stem Cell Division, Cryovault Biotech Pvt Ltd, Bangalore 560016, India.
authors.forename: Basam
authors.initials: B
authors.lastname: Venugopal
authors.affiliation: Stem Cell Division, Cryovault Biotech Pvt Ltd, Bangalore 560016, India.
authors.forename: Punitha
authors.initials: P
authors.lastname: Sekar
authors.affiliation: Department of Biochemistry, Narayana Medical College, Nellore 524002, India.
authors.forename: Krishnan
authors.initials: K
authors.lastname: Ramalingam
mesh_terms: D017209:Apoptosis / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D003920:Diabetes Mellitus / Q000235:genetics* / Q000628:therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics*; D009765:Obesity / Q000235:genetics* / Q000628:therapy
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; C524940:MIRN21 microRNA, human; D035683:MicroRNAs
keywords: Cell proliferation; Diabetes mellitus; MicroRNAs; PTEN; RNAs; miR-21