title: EEG Radiotelemetry in Small Laboratory Rodents: A Powerful State-of-the Art Approach in Neuropsychiatric, Neurodegenerative, and Epilepsy Research.
abstract: EEG radiotelemetry plays an important role in the neurological characterization of transgenic mouse models of neuropsychiatric and neurodegenerative diseases as well as epilepsies providing valuable insights into underlying pathophysiological mechanisms and thereby facilitating the development of new translational approaches. We elaborate on the major advantages of nonrestraining EEG radiotelemetry in contrast to restraining procedures such as tethered systems or jacket systems containing recorders. Whereas a main disadvantage of the latter is their unphysiological, restraining character, telemetric EEG recording overcomes these disadvantages. It allows precise and highly sensitive measurement under various physiological and pathophysiological conditions. Here we present a detailed description of a straightforward successful, quick, and efficient technique for intraperitoneal as well as subcutaneous pouch implantation of a standard radiofrequency transmitter in mice and rats. We further present computerized 3D-stereotaxic placement of both epidural and deep intracerebral electrodes. Preoperative preparation of mice and rats, suitable anaesthesia, and postoperative treatment and pain management are described in detail. A special focus is on fields of application, technical and experimental pitfalls, and technical connections of commercially available radiotelemetry systems with other electrophysiological setups.
authors.affiliation: Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 53175 Bonn, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Lundt
authors.affiliation: Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 53175 Bonn, Germany.
authors.forename: Carola
authors.initials: C
authors.lastname: Wormuth
authors.affiliation: Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 53175 Bonn, Germany; Institute of Physiology, University Medical Center Mainz, 55128 Mainz, Germany.
authors.forename: Magdalena Elisabeth
authors.initials: ME
authors.lastname: Siwek
authors.affiliation: Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Cologne, 50924 Cologne, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Müller
authors.affiliation: German Center for Neurodegenerative Diseases, 53175 Bonn, Germany.
authors.forename: Dan
authors.identifier: 0000-0001-7464-1335
authors.initials: D
authors.lastname: Ehninger
authors.affiliation: Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 53175 Bonn, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Henseler
authors.affiliation: Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 53175 Bonn, Germany.
authors.forename: Karl
authors.initials: K
authors.lastname: Broich
authors.affiliation: Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 53175 Bonn, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Papazoglou
authors.affiliation: Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 53175 Bonn, Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Weiergräber
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000503:physiopathology; D001523:Mental Disorders / Q000503:physiopathology; D051379:Mice; D019636:Neurodegenerative Diseases / Q000503:physiopathology; D051381:Rats; D012106:Research; D013686:Telemetry / Q000379:methods*
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