title: A switchable DNA origami nanochannel for regulating molecular transport at the nanometer scale.
abstract: A nanochannel with a shutter at one end was built by DNA nanotechnology. Using DNA hybridization the shutter could be opened or closed, influencing the transport of materials through the channel. This process was visualized by an enzyme cascade reaction occurring in the structure.
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. liudongsheng@tsinghua.edu.
authors.forename: Dianming
authors.initials: D
authors.lastname: Wang
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. liudongsheng@tsinghua.edu.
authors.forename: Yiyang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. liudongsheng@tsinghua.edu.
authors.forename: Miao
authors.initials: M
authors.lastname: Wang
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. liudongsheng@tsinghua.edu.
authors.forename: Yuanchen
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. liudongsheng@tsinghua.edu.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. liudongsheng@tsinghua.edu.
authors.forename: Mark Antonin
authors.initials: MA
authors.lastname: Isbell
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. liudongsheng@tsinghua.edu.
authors.forename: Zhongqiang
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
authors.forename: Huajie
authors.initials: H
authors.lastname: Liu
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. liudongsheng@tsinghua.edu.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Liu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry*; D005949:Glucose Oxidase / Q000378:metabolism; D006735:Horseradish Peroxidase / Q000378:metabolism; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization
chemical_list: D001672:Biocompatible Materials; D004247:DNA; D005949:Glucose Oxidase; D006735:Horseradish Peroxidase