title: Palm oil and ground nut oil supplementation effects on blood glucose and antioxidant status in alloxan-induced diabetic rats.
abstract: This study investigated the effects of two common cooking oils (palm oil, PO) and (groundnut oil, GO) supplementation on the antioxidant status and diabetic indices in Alloxan (100mg/kg) induced diabetic Wistar rats. A total of forty-eight Wistar rats of both sexes were used for this study. They were divided into four groups of 12 animals each as: control, diabetic non-supplemented, diabetic supplemented with PO (200mg/kg/day) and diabetic supplemented with GO (200mg/kg/day) rats. Blood glucose, plasma vitamin E, SOD, Total Protein and Albumin levels were measured using standard laboratory procedures. After three weeks of supplementation there was a significant (p<0.05) reduction in blood glucose of supplemented groups compared with the diabetic non-supplemented group. Plasma Vitamins C and E, SOD, and Albumin levels were significantly (p<0.05) increased in the supplemented groups when compared with the diabetic non-supplemented group. However, the plasma levels of these parameters were found to be significantly (p<0.05) higher in the GO supplemented rats compared with the PO supplemented group. The plasma vitamin C levels in the diabetic groups were lower than in other groups while increased levels in the plasma total protein were not significant. There was no significant difference in the measured parameters in reference to the gender of the animals. It was concluded from this study that GO exhibited superior antioxidant activities and that the supplementation of red palm oil and ground nut oil as a source of antioxidant was beneficial in diabetic state as it reduced blood glucose and enhance antioxidant status.
authors.affiliation: Chemical Pathology Unit, Department of Medical Laboratory Science, AfeBabalola University, Ado-Ekiti, Nigeria / Nutrition and Chronic Diseases Research Unit, Oxidative Stress Research Centre, Department of Biomedical Sciences, Cape Peninsula University of Technology, Bellville, South Africa.
authors.forename: Olabiyi Folorunso
authors.initials: OF
authors.lastname: Adewale
authors.affiliation: Chemical Pathology Unit, Department of Medical Laboratory Science, Achievers University, Owo, Nigeria.
authors.forename: OlatunjiOlusola
authors.initials: O
authors.lastname: Isaac
authors.affiliation: Chemical Pathology Unit, Department of Medical Laboratory Science, Achievers University, Owo, Nigeria.
authors.forename: Makinwa Temitope
authors.initials: MT
authors.lastname: Tunmise
authors.affiliation: Nutrition and Chronic Diseases Research Unit, Oxidative Stress Research Centre, Department of Biomedical Sciences, Cape Peninsula University of Technology, Bellville, South Africa.
authors.forename: OguntibejuOluwafemi
authors.initials: O
authors.lastname: Omoniyi
mesh_terms: D000496:Alloxan; D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D019587:Dietary Supplements; D005260:Female; D008297:Male; D000073878:Palm Oil; D000074241:Peanut Oil; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D000074241:Peanut Oil; D010938:Plant Oils; D000073878:Palm Oil; D000496:Alloxan