title: Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects.
abstract: Computed Tomography (CT) Perfusion is an evolving method to visualize perfusion in organs and tissue. With the introduction of multidetector CT scanners, it is now possible to cover up to 16 cm in one rotation, and thereby making it possible to scan entire organs such as the liver with a fixed table position. Advances in reconstruction algorithms make it possible to reduce the radiation dose for each examination to acceptable levels. Regarding abdominal imaging, CT perfusion is still considered a research tool, but several studies have proven it as a reliable non-invasive technique for assessment of vascularity. CT perfusion has also been used for tumor characterization, staging of disease, response evaluation of newer drugs targeted towards angiogenesis and as a method for early detection of recurrence after radiation and embolization. There are several software solutions available on the market today based on different perfusion algorithms. However, there is no consensus on which protocol and algorithm to use for specific organs. In this article, the authors give an introduction to CT perfusion in abdominal imaging introducing technical aspects for calculation of perfusion parameters, and considerations on patient preparation. This article also contains clinical cases to illustrate the use of CT perfusion in abdominal imaging.
authors.affiliation: Department of Diagnostic Radiology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark. mlundsgaard@dadlnet.dk.
authors.forename: Martin Lundsgaard
authors.initials: ML
authors.lastname: Hansen
authors.affiliation: Department of Diagnostic Radiology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark. rikke.norling@regionh.dk.
authors.forename: Rikke
authors.initials: R
authors.lastname: Norling
authors.affiliation: Department of Diagnostic Radiology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark. cala@phmetropol.dk.|Metropolitan University College, Radiography Education, Sigurdsgade 26, Copenhagen 2200, Denmark. cala@phmetropol.dk.
authors.forename: Carsten
authors.initials: C
authors.lastname: Lauridsen
authors.affiliation: Department of Diagnostic Radiology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark. eva.fallentin@regionh.dk.
authors.forename: Eva
authors.initials: E
authors.lastname: Fallentin
authors.affiliation: Department of Oncology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark. Lene.baeksgaard.jensen@regionh.dk.
authors.forename: Lene
authors.initials: L
authors.lastname: Bæksgaard
authors.affiliation: Department of Cardiology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark. kkofoed@dadlnet.dk.
authors.forename: Klaus Fuglsang
authors.initials: KF
authors.lastname: Kofoed
authors.affiliation: Department of Surgery C, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark. lars.bo.svendsen@regionh.dk.
authors.forename: Lars Bo
authors.initials: LB
authors.lastname: Svendsen
authors.affiliation: Department of Diagnostic Radiology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark. mbn@dadlnet.dk.
authors.forename: Michael Bachmann
authors.initials: MB
authors.lastname: Nielsen
keywords: CT Perfusion; abdominal imaging; cancer imaging; motion correction
references.citation: Br J Radiol. 2003;76 Spec No 1:S36-42
references.pmid: 15456712
references.citation: Radiology. 2007 Aug;244(2):486-93
references.pmid: 17641369
references.citation: AJNR Am J Neuroradiol. 1999 Jan;20(1):63-73
references.pmid: 9974059
references.citation: Radiology. 2008 Nov;249(2):510-7
references.pmid: 18812560
references.citation: Dig Surg. 2010;27(4):253-60
references.pmid: 20668380
references.citation: Br J Radiol. 2003 Apr;76(904):220-31
references.pmid: 12711641
references.citation: Br J Radiol. 1991 May;64(761):409-12
references.pmid: 2036562
references.citation: Korean J Radiol. 2012 Jan-Feb;13 Suppl 1:S89-97
references.pmid: 22563293
references.citation: Abdom Imaging. 2011 Feb;36(1):15-21
references.pmid: 20336293
references.citation: Eur Radiol. 2012 Feb;22(2):295-301
references.pmid: 21927791
references.citation: Eur Radiol. 2009 Jan;19(1):79-89
references.pmid: 18704434
references.citation: AJR Am J Roentgenol. 2008 Dec;191(6):W288-92
references.pmid: 19020217
references.citation: Eur J Radiol. 1999 Jun;30(3):198-205
references.pmid: 10452718
references.citation: Radiology. 2008 Jun;247(3):726-32
references.pmid: 18403621
references.citation: Radiology. 2009 Feb;250(2):407-16
references.pmid: 19095784
references.citation: Insights Imaging. 2012 Aug;3(4):323-8
references.pmid: 22695948
references.citation: Abdom Imaging. 2009 Nov;34(6):759-66
references.pmid: 19672566
references.citation: AJR Am J Roentgenol. 2005 Jul;185(1):225-31
references.pmid: 15972428
references.citation: Radiology. 2011 Sep;260(3):762-70
references.pmid: 21788525
references.citation: World J Gastroenterol. 2010 Dec 21;16(47):5993-6000
references.pmid: 21157976
references.citation: EJNMMI Res. 2011 Nov 18;1(1):28
references.pmid: 22214473
references.citation: Phys Med Biol. 2008 Aug 21;53(16):4249-67
references.pmid: 18653923
references.citation: J Comput Assist Tomogr. 1999 Jul-Aug;23 (4):506-15
references.pmid: 10433275
references.citation: Acad Radiol. 2004 Oct;11(10 ):1085-92
references.pmid: 15530801
references.citation: Cancer Imaging. 2010 Feb 11;10 :8-19
references.pmid: 20159664
references.citation: World J Gastroenterol. 2005 Mar 7;11(9):1287-91
references.pmid: 15761965
references.citation: J Comput Assist Tomogr. 2011 Jul-Aug;35(4):434-8
references.pmid: 21765297
references.citation: Int J Biomed Imaging. 2011;2011:467563
references.pmid: 21904538
references.citation: Semin Radiat Oncol. 2011 Apr;21(2):147-56
references.pmid: 21356482
references.citation: Stroke. 2006 Apr;37(4):979-85
references.pmid: 16514093
references.citation: Eur Radiol. 2011 May;21(5):974-81
references.pmid: 21085968
references.citation: AJR Am J Roentgenol. 2009 Sep;193(3):764-71
references.pmid: 19696291
references.citation: Radiol Clin North Am. 2009 Jan;47(1):161-78
references.pmid: 19195541
references.citation: Radiology. 1993 Aug;188(2):405-11
references.pmid: 8327686
references.citation: Eur J Radiol. 2012 Nov;81(11):3048-54
references.pmid: 22613507
references.citation: Eur Radiol. 2009 Nov;19(11):2641-6
references.pmid: 19471941
references.citation: Int J Inflam. 2012;2012:497386
references.pmid: 22518337
references.citation: Eur J Radiol. 2012 Sep;81(9):2075-9
references.pmid: 21802233
references.citation: AJNR Am J Neuroradiol. 2004 Jan;25(1):97-107
references.pmid: 14729537
references.citation: J Comput Assist Tomogr. 1995 May-Jun;19(3):424-33
references.pmid: 7790553