title: Properties of carbon nanotube-dispersed Sr-hydroxyapatite injectable material for bone defects.
abstract: This study concerns the synthesis of gel materials based on carbon nanotubes dispersed strontium-modified hydroxyapatite (Sr-HA) at different compositions obtained by sol-gel technology and their influence on human-bone-marrow-derived mesenchymal stem cells. Furthermore, an evaluation of the influence of nanotubes and Strontium on physico-chemical, morphological, rheological and biological properties of hydroxyapatite gel was also performed. Morphological analysis (scanning electron microscopy) shows a homogeneous distribution of modified nanotubes in the ceramic matrix improving the bioactive properties of materials. The biological investigations proved that Sr-HA/carbon nanotube gel containing 0-20 mol (%) of Sr showed no toxic effect and promote the expression of early and late markers of osteogenic differentiation in cell culture performed in basal medium without osteogenic factors. Finally, the SrHA/carbon nanotube gels could have a good potential application as filler in bone repair and regeneration and may be used in the osteoporotic disease treatment.
authors.affiliation: Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra D'oltremare Pad.20 - Viale Kennedy 54, Naples 80125, Italy;
authors.forename: M G
authors.initials: MG
authors.lastname: Raucci
authors.affiliation: Tissue Bioengineering Laboratory, DEPeI, Faculty of Dentistry, National Autonomous University of Mexico, Mexico DF 04510, Mexico;
authors.forename: M
authors.initials: M
authors.lastname: Alvarez-Perez
authors.affiliation: Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra D'oltremare Pad.20 - Viale Kennedy 54, Naples 80125, Italy;
authors.forename: D
authors.initials: D
authors.lastname: Giugliano
authors.affiliation: Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra D'oltremare Pad.20 - Viale Kennedy 54, Naples 80125, Italy;
authors.forename: S
authors.initials: S
authors.lastname: Zeppetelli
authors.affiliation: Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra D'oltremare Pad.20 - Viale Kennedy 54, Naples 80125, Italy;; Department of Chemical Sciences and Materials Technology, National Research Council of Italy, (DSCTM-CNR), P.Le Aldo Moro 7, Rome 00185, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Ambrosio
keywords: bioceramics; biomaterial-cell interaction; bone tissue engineering; nanobiomaterials; sol-gel tecnology
references.citation: Artif Organs. 2000 Mar;24(3):212-6
references.pmid: 10759644
references.citation: Histochem J. 2001 Jan;33(1):25-35
references.pmid: 11352398
references.citation: Nat Mater. 2003 Jan;2(1):15-6
references.pmid: 12652665
references.citation: Biomaterials. 2005 May;26(13):1553-63
references.pmid: 15522757
references.citation: J Mater Sci Mater Med. 2005 Nov;16(11):993-1001
references.pmid: 16388381
references.citation: Biomaterials. 2006 May;27(15):2907-15
references.pmid: 16448693
references.citation: Biomacromolecules. 2006 Jul;7(7):2237-42
references.pmid: 16827593
references.citation: Biomaterials. 2007 Feb;28(4):618-24
references.pmid: 17007921
references.citation: Toxicol Lett. 2007 Jan 10;168(1):58-74
references.pmid: 17141434
references.citation: Toxicol Lett. 2007 Jan 30;168(2):121-31
references.pmid: 17169512
references.citation: J Mater Sci Mater Med. 2008 Oct;19(10):3279-85
references.pmid: 18483788
references.citation: Cell Physiol Biochem. 2009;23(1-3):165-74
references.pmid: 19255511
references.citation: Nano Lett. 2009 Apr;9(4):1406-13
references.pmid: 19284728
references.citation: J Nippon Med Sch. 2010 Feb;77(1):4-12
references.pmid: 20154452
references.citation: Acta Biomater. 2011 Feb;7(2):800-8
references.pmid: 20826233
references.citation: ACS Nano. 2010 Dec 28;4(12):7717-25
references.pmid: 21117641
references.citation: J Nanosci Nanotechnol. 2012 Jan;12(1):207-12
references.pmid: 22523967
references.citation: Sensors (Basel). 2012;12(9):12347-60
references.pmid: 23112716
references.citation: Calcif Tissue Int. 2013 Oct;93(4):299-306
references.pmid: 23183786
references.citation: J Biomed Mater Res A. 2013 Jul;101(7):1955-61
references.pmid: 23225789
references.citation: Acta Biomater. 2013 Dec;9(12):9547-57
references.pmid: 23917042
references.citation: Biomed Res Int. 2014;2014:814057
references.pmid: 24800251
references.citation: J Biomed Mater Res A. 2015 May;103(5):1732-45
references.pmid: 25131439
references.citation: J Cell Physiol. 2015 Mar;230(3):568-77
references.pmid: 25160656
references.citation: J Mater Sci Mater Med. 2015 Feb;26(2):90
references.pmid: 25649515
references.citation: J Endocrinol. 2015 Apr;225(1):R1-19
references.pmid: 25655764
references.citation: PLoS One. 2015 Mar 18;10(3):e0120087
references.pmid: 25785438
references.citation: Curr Osteoporos Rep. 2015 Jun;13(3):180-5
references.pmid: 25809656
references.citation: Materials (Basel). 2013 Jun 03;6(6):2274-2284
references.pmid: 28809273