title: Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.
abstract: Covering: 1992 to 2015The natural products FR901464, pladienolide, and herboxidiene were discovered as activators of reporter gene systems. Unexpectedly, these compounds target neither transcription nor translation; rather, they target splicing factor 3B subunit 1 of the spliceosome, causing changes in splicing patterns. All of them showed anticancer activity in a low nanomolar range. Since their discovery, these molecules have been used in a variety of biological applications.
authors.affiliation: Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA. koide@pitt.edu.
authors.forename: Dianne
authors.initials: D
authors.lastname: Pham
authors.affiliation: Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA. koide@pitt.edu.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Koide
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D005233:Fatty Alcohols / Q000494:pharmacology; D015394:Molecular Structure; D011714:Pyrans / Q000494:pharmacology; D012326:RNA Splicing / Q000187:drug effects; D000072260:RNA Splicing Factors; D013141:Spiro Compounds / Q000494:pharmacology; D017381:Spliceosomes / Q000187:drug effects
chemical_list: D001688:Biological Products; C104486:FR 901464; D005233:Fatty Alcohols; D011714:Pyrans; D000072260:RNA Splicing Factors; D013141:Spiro Compounds; C076087:herboxidiene