title: [The impact of long- and short-time blood pressure variability on glomerular filtration rate in elderly population].
abstract: OBJECTIVE
  To investigate the impact of long-time and short-time blood pressure variability (BPV) on glomerular filtration rate (eGFR) in elderly population.
  
  
  METHODS
  A total of 2 464 participants aged of ≥60 years old without history of stroke and coronary heart disease were selected with random sampling method from the individuals underwent health check up in Tangshan Kailuan Hospital, Kailuan Linxi Hospital, Kailuan Zhaogezhuang Hospital between 2006 and 2013. The study participants were asked to join a face-to-face interview every two years. Long-time BPV was defined as the standard deviation of all SBP values at the baseline visit and following visits, short-time BPV was defined as the standard deviation of day time blood pressure and night time blood pressure which was derived from 24 hours ambulatory blood pressure monitoring. Multivariate linear regression models were used to test the impact of long- and short-time BPV on eGFR.
  
  
  RESULTS
  The study included 3 participants groups including the long-time SBPV group (2 279 participants), the short-time SBPV group (1 636 participants) and the long- plus short-time SBPV group (1 632 participants). Participants were further sub grouped by median value (NO.1<meadian and NO.2>median value). eGFR in the long-time SBPV NO.1 and NO.2 group was 83.19 and 81.49 ml·min(-1)·1.73 m(-2) respectively, in the short time SBPV NO.1 and NO.2 group was 83.53 and 80.81ml·min(-1)·1.73 m(-2) of the day time, and was 83.20 and 81.14 ml·min(-1)·1.73 m(-2) of the night time, respectively. eGFR in the long- plus short-time SBPV NO.1 and NO.2 group was 83.21 and 81.08 ml·min(-1)·1.73 m(-2) of the long-time SBPV, and was 83.53 and 80.75 ml·min(-1)·1.73 m(-2) of the day time, and was 83.18 and 81.11 ml·min(-1)·1.73 m(-2) of the night time. Significant linear relationship was found between higher day time SBPV and lower eGFR (P<0.05). After adjusting for confounding parameters including age, sex, body mass index, 1 mmHg(1 mmHg=0.133 kPa) of day time SBPV increase was related 0.21 ml·min(-1)·1.73 m(-2) eGFR decrease (P<0.05).
  
  
  CONCLUSIONS
  The higher day time SBPV is associated with reduced eGFR in the elderly population.Clinical Trail Registry Chinese Clinical Trial Registry, ChiCTR-TNC-11001489.
authors.affiliation: Department of Cardiology, Kailuan Hospital, Tangshan 063000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zheng
authors.forename: Shasha
authors.initials: S
authors.lastname: An
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Li
authors.forename: Wenyan
authors.initials: W
authors.lastname: Zhang
authors.forename: Chunhui
authors.initials: C
authors.lastname: Li
authors.forename: Hualing
authors.initials: H
authors.lastname: Zhao
authors.forename: Lu
authors.initials: L
authors.lastname: Song
authors.forename: Shuohua
authors.initials: S
authors.lastname: Chen
authors.forename: Yao
authors.initials: Y
authors.lastname: Zheng
authors.forename: Chunyu
authors.initials: C
authors.lastname: Ruan
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
mesh_terms: D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D003327:Coronary Disease; D005919:Glomerular Filtration Rate; D006801:Humans; D013997:Time Factors