title: Drug levels, immunogenicity and assessment of active sacroiliitis in patients with axial spondyloarthritis under biologic tapering strategy.
abstract: The aim of the study was to assess drug levels, immunogenicity and sacroiliitis on MRI in patients with axial spondyloarthritis under biologic tapering strategy. Consecutive patients with axial spondyloarthritis who remained in low disease activity more than 1 year after dose tapering of infliximab and adalimumab were included. Plasma drug concentrations of TNF inhibitors and anti-drug antibodies were determined, and MRI of sacroiliac joints was evaluated. Of twenty patients included, eighteen had therapeutic drug levels, no patient had anti-drug antibodies, and no patient had active sacroiliitis on MRI. These data could support the biologic tapering strategy and their maintenance over time.
authors.affiliation: Department of Rheumatology, Parc de Salut Mar, Universidad Autónoma de Barcelona, Passeig Marítim 25-29, 08003, Barcelona, Spain. REU0802@parcdesalutmar.cat.
authors.forename: Miriam
authors.initials: M
authors.lastname: Almirall
authors.affiliation: Department of Immunology, Instituto Municipal de Investigación Médica (IMIM), Barcelona, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Gimeno
authors.affiliation: Department of Rheumatology, Parc de Salut Mar, Universidad Autónoma de Barcelona, Passeig Marítim 25-29, 08003, Barcelona, Spain.
authors.forename: Tarek Carlos
authors.initials: TC
authors.lastname: Salman-Monte
authors.affiliation: Department of Rheumatology, Parc de Salut Mar, Universidad Autónoma de Barcelona, Passeig Marítim 25-29, 08003, Barcelona, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Iniesta
authors.affiliation: Department of Rheumatology, Parc de Salut Mar, Universidad Autónoma de Barcelona, Passeig Marítim 25-29, 08003, Barcelona, Spain.
authors.forename: Maria Pilar
authors.initials: MP
authors.lastname: Lisbona
authors.affiliation: Department of Rheumatology, Parc de Salut Mar, Universidad Autónoma de Barcelona, Passeig Marítim 25-29, 08003, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Maymó
mesh_terms: D000068879:Adalimumab / Q000008:administration & dosage* / Q000097:blood / Q000276:immunology; D000328:Adult; D000906:Antibodies / Q000097:blood*; D001688:Biological Products / Q000008:administration & dosage* / Q000097:blood; D003430:Cross-Sectional Studies; D004334:Drug Administration Schedule; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D000069285:Infliximab / Q000008:administration & dosage* / Q000097:blood / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging / Q000187:drug effects*; D058566:Sacroiliitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000276:immunology; D025241:Spondylarthritis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D001688:Biological Products; D000069285:Infliximab; D000068879:Adalimumab
keywords: Active sacroiliitis; Axial spondyloarthritis; Biologic tapering strategy; Immunogenicity
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