title: An innovative regenerative treatment of scars with dermal micrografts.
abstract: BACKGROUND
  Pathological scars occur following injuries and are often considered esthetically unattractive. Several strategies have been attempted to improve these types of scars using both surgical and nonsurgical methods. The most common treatments include cryotherapy, intralesional corticosteroid injections, 5-fluorouracil, bleomycin, interferon, and verapamil.
  
  
  OBJECTIVE
  In this study, we aim to investigate the effectiveness of dermal autologous micrografts in the treatment of pathological scars resulting from burns, trauma, or any iatrogenic source.
  
  
  METHODS
  We used a new clinical practice called Rigenera Protocol to obtain autologous micrografts which were in turn injectable in the patients.
  
  
  RESULTS
  A significant improvement was observed in appearance and texture of the exaggerated scars in all cases following already 4 months of autologous micrograft treatment We have also shown that these micrografts are composed of mesenchymal stem cells and in addition, histological evaluation verified restoration of the structural layers immediately below the epidermis and a horizontal realignment of collagen fibers in the papillary dermis.
  
  
  CONCLUSIONS
  Our results clearly demonstrate the optimal outcomes obtained following treatment with dermal micrografts on exaggerated scars with different etiologies. However, further studies are required to confirm the efficacy of this new technique.
authors.affiliation: Centre of Nanoscience, Mavi Sud, Aprilia, Italy.
authors.forename: Fabiano
authors.initials: F
authors.lastname: Svolacchia
authors.affiliation: Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: De Francesco
authors.affiliation: Human Brain Wave srl, Turin, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Trovato
authors.affiliation: Human Brain Wave srl, Turin, Italy.|SHRO - Temple University of Philadelphia, Philadelphia, PA, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Graziano
authors.affiliation: Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
authors.forename: Giuseppe A
authors.initials: GA
authors.lastname: Ferraro
mesh_terms: D000328:Adult; D064592:Autografts / Q000166:cytology; D002921:Cicatrix / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells; D012038:Regeneration; D012879:Skin Physiological Phenomena; D016038:Skin Transplantation / Q000379:methods*
keywords: Rigenera; hypertrophic scars; keloid; mesenchymal stem cells; micrograft