title: Synthetic Biomaterials from Metabolically Derived Synthons.
abstract: The utility of metabolic synthons as the building blocks for new biomaterials is based on the early application and success of hydroxy acid based polyesters as degradable sutures and controlled drug delivery matrices. The sheer number of potential monomers derived from the metabolome (e.g., lactic acid, dihydroxyacetone, glycerol, fumarate) gives rise to almost limitless biomaterial structural possibilities, functionality, and performance characteristics, as well as opportunities for the synthesis of new polymers. This review describes recent advances in new chemistries, as well as the inventive use of traditional chemistries, toward the design and synthesis of new polymers. Specific polymeric biomaterials can be prepared for use in varied medical applications (e.g., drug delivery, tissue engineering, wound repair, etc.) through judicious selection of the monomer and backbone linkage.
authors.affiliation: School of Chemical and Biomolecular Engineering, Cornell University , Ithaca, New York 14853, United States.
authors.forename: Nicole G
authors.initials: NG
authors.lastname: Ricapito
authors.affiliation: Department of Chemistry, Boston University , Boston, Massachusetts 02215, United States.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Ghobril
authors.affiliation: Department of Chemistry, Boston University , Boston, Massachusetts 02215, United States.
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Boston University , Boston, Massachusetts 02215, United States.|Department of Biomedical Engineering, Boston University , Boston, Massachusetts 02215, United States.|Department of Medicine, Boston University School of Medicine , Boston, Massachusetts 02118, United States.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Grinstaff
authors.affiliation: School of Chemical and Biomolecular Engineering, Cornell University , Ithaca, New York 14853, United States.|Meinig School of Biomedical Engineering, Cornell University , Ithaca, New York 14853, United States.
authors.forename: David
authors.initials: D
authors.lastname: Putnam
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D004098:Dihydroxyacetone / Q000737:chemistry / Q000378:metabolism; D005990:Glycerol / Q000737:chemistry / Q000378:metabolism; D006880:Hydroxy Acids / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D001672:Biocompatible Materials; D006880:Hydroxy Acids; D011108:Polymers; D004098:Dihydroxyacetone; D005990:Glycerol
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