title: Malignant Peripheral Nerve Sheath Tumor of the Liver.
abstract: Malignant peripheral nerve sheath tumor (MPNST) of the liver is rare. Most cases of MPNST are accompanied by neurofibromatosis 1 (NF-1, von Recklinghausen's disease). We herein report an autopsy case of MPNST without NF-1 and review the pertinent literature. The tumor occupied the entire lobe of the liver, and was 18 cm in maximum diameter. The tumor revealed necrosis and cystic changes with hemorrhage and it had also metastasized to the peritoneum. Microscopically, the tumor was composed of pleomorphic spindle cells with hyperchromatic nuclei and mitogenic figures. The spindle cells stained positive for both S-100 and vimentin antibodies.
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kakizaki
authors.forename: Norio
authors.initials: N
authors.lastname: Horiguchi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Otsuka
authors.forename: Daichi
authors.initials: D
authors.lastname: Takizawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ohno
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Kusano
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000368:Aged; D000906:Antibodies / Q000032:analysis; D001344:Autopsy; D005260:Female; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000473:pathology*; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology*; D018317:Nerve Sheath Neoplasms / Q000737:chemistry / Q000473:pathology*; D009418:S100 Proteins / Q000276:immunology; D014746:Vimentin / Q000276:immunology
chemical_list: D000906:Antibodies; D009418:S100 Proteins; D014746:Vimentin