title: Trichloromethylthiolation of N-Heterocycles: Practical and Completely Regioselective.
abstract: The first trichloromethylthiolation of a broad range of indoles and pyrroles is reported employing bench-stable N-trichloromethylthiosaccharin as reagent. This methodology is highly regioselective, exhibits high functional group tolerance, and provides access to two previously unknown classes of potentially bioactive compounds.
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
authors.forename: Johannes B
authors.initials: JB
authors.lastname: Ernst
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Rühling
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Wibbeling
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany. glorius@uni-muenster.de.
authors.forename: Frank
authors.identifier: http://orcid.org/0000-0002-0648-956X
authors.initials: F
authors.lastname: Glorius
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006860:Hydrogen Bonding; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D012439:Saccharin / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; C000611490:N-trichloromethylthiosaccharin; D012439:Saccharin
keywords: bioactive compounds; electrophilic substitution; heterocycles; organic chemistry; trichloromethylthiolation