title: Huangqi Jianzhong Tang for Treatment of Chronic Gastritis: A Systematic Review of Randomized Clinical Trials.
abstract: To assess the clinical effects and safety of Huangqi Jianzhong Tang (HQJZ) for the treatment of chronic gastritis (CG), three English databases and four Chinese databases were searched through the inception to January 2015. In randomized controlled trials (RCTs) comparing HQJZ with placebo, no intervention and western medicine were included. A total of 9 RCTs involving 979 participants were identified. The methodological quality of the included trials was generally poor. Meta-analyses demonstrated that HQJZ plus conventional medicine was more effective in improving overall gastroscopy outcome than western medicine alone for treatment of chronic superficial gastritis with the pooling result of overall improvement [OR 3.78 (1.29,11.06), P = 0.02]. In addition, the combination of HQJZ with antibiotics has higher overall effect rate than antibiotics alone for the treatment of CG [OR 2.60 (1.49,4.54), P = 0.0007]. There were no serious adverse events reported in both the intervention and controlled groups. HQJZ has the potential of improvement of the patients' gastroscopy outcomes, Helicobacter pylori clearance rate, traditional Chinese Medicine syndromes, and overall effect rate alone or in combination use with conventional western medicine for chronic atrophic gastritis. However, due to poor methodological quality, the beneficial effect and safeties of HQJZ for CG could not be confirmed.
authors.affiliation: The Third Affiliated Hospital of Beijing University of Chinese Medicine, 51 An Wai Xiaoguan Street, Chaoyang District, Beijing 100029, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Hebei University, Baoding, Hebei, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Ma
authors.affiliation: The Second Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Yin
authors.affiliation: The Third Affiliated Hospital of Beijing University of Chinese Medicine, 51 An Wai Xiaoguan Street, Chaoyang District, Beijing 100029, China.
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.affiliation: General Forestry Station of Beijing Municipality, Beijing, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wei
authors.affiliation: The Third Affiliated Hospital of Beijing University of Chinese Medicine, 51 An Wai Xiaoguan Street, Chaoyang District, Beijing 100029, China.
authors.forename: Jin-Xiang
authors.initials: JX
authors.lastname: Yang
references.citation: Am J Gastroenterol. 2003 Nov;98(11):2395-402
references.pmid: 14638339
references.citation: Evid Based Complement Alternat Med. 2013;2013:574629
references.pmid: 23840258
references.citation: Best Pract Res Clin Gastroenterol. 2014 Dec;28(6):1031-42
references.pmid: 25439069
references.citation: Gut. 2012 May;61(5):646-64
references.pmid: 22491499
references.citation: Acta Pharmacol Sin. 2002 Aug;23 (8):757-61
references.pmid: 12147200
references.citation: Arch Pathol Lab Med. 2008 Oct;132(10):1586-93
references.pmid: 18834216
references.citation: Gut. 2007 May;56(5):631-6
references.pmid: 17142647
references.citation: J Gastroenterol Hepatol. 2005 Mar;20(3):401-4
references.pmid: 15740483
references.citation: Endoscopy. 2012 Jan;44(1):74-94
references.pmid: 22198778