title: In vitro hemocompatibility on thin ceramic and hydrogel films deposited on polymer substrate performed in arterial flow conditions.
abstract: Hydrogel coatings were stabilized by titanium carbonitride a-C:H:Ti:N buffer layers deposited directly onto the polyurethane (PU) substrate beneath a final hydrogel coating. Coatings of a-C:H:Ti:N were deposited using a hybrid method of pulsed laser deposition (PLD) and magnetron sputtering (MS) under high vacuum conditions. The influence of the buffer a-C:H:Ti:N layer on the hydrogel coating was analysed by means of a multi-scale microstructure study. Mechanical tests were performed at an indentation load of 5 mN using Berkovich indenter geometry. Haemocompatible analyses were performed in vitro using a blood flow simulator. The blood-material interaction was analysed under dynamic conditions. The coating fabrication procedure improved the coating stability due to the deposition of the amorphous titanium carbonitride buffer layer.
authors.affiliation: Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Reymonta St. 25, Krakow, Poland. Electronic address: r.major@imim.pl.
authors.forename: Roman
authors.initials: R
authors.lastname: Major
authors.affiliation: Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Reymonta St. 25, Krakow, Poland.
authors.forename: Klaudia
authors.initials: K
authors.lastname: Trembecka-Wójciga
authors.affiliation: AGH University of Science and Technology, Faculty of Mechanical, Engineering and Robotics, Al. Mickiewicza 30, 30-059 Krakow, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Kot
authors.affiliation: Joanneum Research Forschungs-GmbH, Materials - Functional Surfaces, Leoben, Austria.
authors.forename: Juergen M
authors.initials: JM
authors.lastname: Lackner
authors.affiliation: Heart Prosthesis Institute, Bioengineering Laboratory, Wolnosci 345A, 41-800 Zabrze, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Wilczek
authors.affiliation: Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Reymonta St. 25, Krakow, Poland.
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Major
mesh_terms: D001773:Blood Cells / Q000166:cytology / Q000378:metabolism*; D001783:Blood Flow Velocity; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D008567:Membranes, Artificial; D011140:Polyurethanes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D020099:Coated Materials, Biocompatible; D020100:Hydrogels; D008567:Membranes, Artificial; D011140:Polyurethanes
keywords: Biocompatibility; Blood-material interactions; Hydrogel coatings; Microstructure