title: [STRUCTURAL AND FUNCTIONAL CHANGES MYOCARDIUM HYPERTENSIVE RATS IN APPLYING INDAPAMIDE AND ELLAGIC ACID].
abstract: The article investigates the effectiveness of antihypertensive properties of indapamide and ellagic acid in hypertensive rats. As a result of experimental studies determined the effect of drugs on blood pressure and structural recovery of the myocardium of hypertensive rats. Indapamid with ellagic acid reduces the degradation of contractile myofibrils, mitochondria lysis and swelling of the cytoplasm of cardiomyocytes. The study drug is a normalizing effect on the se parameters. The combined use of indapamid and ellagic acid enhances the structural and functional recovery of myocardium energy metabolism normalizes organelles.
authors.forename: R S
authors.initials: RS
authors.lastname: Dougan
authors.forename: I S
authors.initials: IS
authors.lastname: Chekman
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D004610:Ellagic Acid / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D007190:Indapamide / Q000494:pharmacology*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D009210:Myofibrils / Q000187:drug effects / Q000648:ultrastructure; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D000959:Antihypertensive Agents; D004610:Ellagic Acid; D007190:Indapamide