title: Efficacy and safety of insulin degludec in Japanese patients with type 1 and type 2 diabetes: 24-week results from the observational study in routine clinical practice.
abstract: This is first observational prospective study of insulin degludec in routine clinical practice that we evaluated the effect on glycemic control and risk of hypoglycemia in basal-bolus insulin therapy. We found that insulin degludec can maintain glycemic control at a lower insulin dose and frequency of hypoglycemia in type 1 diabetes, while it can improve glycemic control at equally insulin dose in type 2 diabetes. These results mean that insulin degludec is of use in routine clinical practice.
authors.affiliation: Department of Molecular and Internal Medicine Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kobuke
authors.affiliation: Department of Molecular and Internal Medicine Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan.
authors.forename: Masayasu
authors.initials: M
authors.lastname: Yoneda
authors.affiliation: Department of Metabolism and Endocrinology Hiroshima Red Cross Hospital & Atomic Bomb Survivors Hospital Hiroshima Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nakanishi
authors.affiliation: Department of Molecular and Internal Medicine Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan.
authors.forename: Haruya
authors.initials: H
authors.lastname: Ohno
authors.affiliation: Department of Molecular and Internal Medicine Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan.
authors.forename: Shusaku
authors.initials: S
authors.lastname: Maeda
authors.affiliation: Egusa Genshi Clinic Hiroshima Japan.
authors.forename: Genshi
authors.initials: G
authors.lastname: Egusa
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D049528:Insulin, Long-Acting / Q000008:administration & dosage* / Q000009:adverse effects; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D049528:Insulin, Long-Acting; C571886:insulin degludec
keywords: Basal–bolus treatment; Hypoglycemia; Insulin degludec
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