title: Multiple Functions of MSCA-1/TNAP in Adult Mesenchymal Progenitor/Stromal Cells.
abstract: Our knowledge about mesenchymal stem cells has considerably grown in the last years. Since the proof of concept of the existence of such cells in the 70s by Friedenstein et al., a growing mass of reports were conducted for a better definition of these cells and for the reevaluation from the term "mesenchymal stem cells" to the term "mesenchymal stromal cells (MSCs)." Being more than a semantic shift, concepts behind this new terminology reveal the complexity and the heterogeneity of the cells grouped in MSC family especially as these cells are present in nearly all adult tissues. Recently, mesenchymal stromal cell antigen-1 (MSCA-1)/tissue nonspecific alkaline phosphatase (TNAP) was described as a new cell surface marker of MSCs from different tissues. The alkaline phosphatase activity of this protein could be involved in wide range of MSC features described below from cell differentiation to immunomodulatory properties, as well as occurrence of pathologies. The present review aims to decipher and summarize the role of TNAP in progenitor cells from different tissues focusing preferentially on brain, bone marrow, and adipose tissue.
authors.affiliation: Inserm UMR 1048, Team 1, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, 1 avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.
authors.forename: David
authors.initials: D
authors.lastname: Estève
authors.affiliation: Inserm UMR 1048, Team 1, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, 1 avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Galitzky
authors.affiliation: Inserm UMR 1048, Team 1, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, 1 avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Bouloumié
authors.affiliation: CNRS UMR 5549, Brain and Cognition Research Center, Pavillon Baudot, CHU Purpan, BP 25202, 31052 Toulouse Cedex 3, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Fonta
authors.affiliation: CNRS UMR 5246, Institute of Molecular and Supramolecular Chemistry and Biochemistry (ICBMS), University of Lyon, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France.
authors.forename: René
authors.initials: R
authors.lastname: Buchet
authors.affiliation: CNRS UMR 5246, Institute of Molecular and Supramolecular Chemistry and Biochemistry (ICBMS), University of Lyon, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France.
authors.forename: David
authors.initials: D
authors.lastname: Magne
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