title: Spatial structure of neuronal receptive field in awake monkey secondary visual cortex (V2).
abstract: Visual processing depends critically on the receptive field (RF) properties of visual neurons. However, comprehensive characterization of RFs beyond the primary visual cortex (V1) remains a challenge. Here we report fine RF structures in secondary visual cortex (V2) of awake macaque monkeys, identified through a projection pursuit regression analysis of neuronal responses to natural images. We found that V2 RFs could be broadly classified as V1-like (typical Gabor-shaped subunits), ultralong (subunits with high aspect ratios), or complex-shaped (subunits with multiple oriented components). Furthermore, single-unit recordings from functional domains identified by intrinsic optical imaging showed that neurons with ultralong RFs were primarily localized within pale stripes, whereas neurons with complex-shaped RFs were more concentrated in thin stripes. Thus, by combining single-unit recording with optical imaging and a computational approach, we identified RF subunits underlying spatial feature selectivity of V2 neurons and demonstrated the functional organization of these RF properties.
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Shanghai 200031, China;
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Shanghai 200031, China;
authors.forename: Liang
authors.initials: L
authors.lastname: She
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Shanghai 200031, China;
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;
authors.forename: Tianyi
authors.initials: T
authors.lastname: Liu
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;
authors.forename: Haidong D
authors.initials: HD
authors.lastname: Lu
authors.affiliation: Division of Neurobiology, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720.
authors.forename: Yang
authors.initials: Y
authors.lastname: Dan
authors.affiliation: Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; mpoo@ion.ac.cn.
authors.forename: Mu-ming
authors.initials: MM
authors.lastname: Poo
mesh_terms: D000818:Animals; D008251:Macaca / Q000502:physiology*; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D014851:Wakefulness
keywords: V2; natural images; receptive field; stripes
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