title: [Phosphate metabolism and iron deficiency].
abstract: Autosomal dominant hypophosphatemic rickets(ADHR)is caused by gain-of-function mutations in FGF23 that prevent its proteolytic cleavage. Fibroblast growth factor 23(FGF23)is a hormone that inhibits renal phosphate reabsorption and 1,25-dihydroxyvitamin D biosynthesis. Low iron status plays a role in the pathophysiology of ADHR. Iron deficiency is an environmental trigger that stimulates FGF23 expression and hypophosphatemia in ADHR. It was reported that FGF23 elevation in patients with CKD, who are often iron deficient. In patients with nondialysis-dependent CKD, treatment with ferric citrate hydrate resulted in significant reductions in serum phosphate and FGF23.
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine,The Jikei University School of Medicine, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Yokoyama
mesh_terms: D015415:Biomarkers / Q000097:blood; D002117:Calcitriol / Q000096:biosynthesis; D053098:Familial Hypophosphatemic Rickets / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D005290:Ferric Compounds / Q000494:pharmacology / Q000627:therapeutic use; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000502:physiology*; D000090463:Iron Deficiencies; D007668:Kidney / Q000378:metabolism; D009154:Mutation; D010710:Phosphates / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy / Q000378:metabolism
chemical_list: D015415:Biomarkers; C000717427:FGF23 protein, human; D005290:Ferric Compounds; D010710:Phosphates; D005346:Fibroblast Growth Factors; C025314:ferric citrate; D000089703:Fibroblast Growth Factor-23; D007501:Iron; D002117:Calcitriol