title: Synthesis of 1,2-Disubstituted Indoles from α-Aminonitriles and 2-Halobenzyl Halides.
abstract: The α-alkylation of deprotonated Strecker products derived from primary amines and aromatic aldehydes with 2-halobenzyl halides furnishes intermediates that can be cyclized to 1,2-disubstituted indoles in moderate to high yields (up to 94% over two steps) by microwave-assisted copper- or palladium-catalyzed intramolecular cross-coupling.
authors.affiliation: Institute of Organic Chemistry, Johannes Gutenberg-University , Duesbergweg 10-14, D-55128 Mainz, Germany.
authors.forename: Anne-Katrin
authors.initials: AK
authors.lastname: Bachon
authors.affiliation: Institute of Organic Chemistry, Johannes Gutenberg-University , Duesbergweg 10-14, D-55128 Mainz, Germany.
authors.forename: Till
authors.initials: T
authors.lastname: Opatz