title: Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats.
abstract: BACKGROUND
  Even though Curcuma longa L. possesses various biological activities, it has strong flavor and taste, which decrease consumer palatability and limit industrial applications in food.
  
  
  OBJECTIVE
  The present study investigates the effects of C. longa L. fermented with Aspergillus oryzae supplementation in 60% high-fat diet-induced obese rats measured by the activation of adipogenesis and lipolysis.
  
  
  METHODS
  Rats were divided into four groups (n=6 per group) after 1 week of acclimatization: a normal diet group comprised rats fed the AIN76A rodent diet; a high-fat diet-induced obese group with rats fed a 60% high-fat diet; a Garcinia cambogia treated group (positive control) with rats fed a 60% high-fat diet with G. cambogia 500 g/kg body weight (b.w.)/day; and an fermented C. longa L. 50% ethanolic extract treated group (FCE50) with rats fed a 60% high-fat diet with FCE50 500 g/kg b.w./day. Each group received the appropriate vehicle or sample daily by gastric intubation for 12 weeks.
  
  
  RESULTS
  We found that FCE50 administration suppressed b.w. gain and reduced white adipose tissue weight, serum triglyceride (TG), and cholesterol in high-fat diet-induced obese rats. These results can be associated with the suppression of adipocyte differentiation and lipogenesis with a decrease in the mRNA expressions of fatty acid synthase, acetyl-CoA carboxylase, adipocyte protein 2, and lipoprotein lipase induced by FCE50 administration. In addition, FCE50 increased lipolysis and β-oxidation by up-regulating the expression of lipases such as adipose triglyceride lipase, hormone-sensitive lipase, adiponectin, and AMP-activated protein kinase.
  
  
  CONCLUSIONS
  These results suggest that FCE50 can be a candidate for the prevention of obesity via suppressing adipogenesis and promoting lipolysis.
authors.affiliation: Division of Food and Nutritional Science, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Division of Food and Nutritional Science, Chonnam National University, Gwangju, Republic of Korea.|Research Institute for Human Ecology, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Ok-Kyung
authors.initials: OK
authors.lastname: Kim
authors.affiliation: Department of Biochemistry and Molecular Biology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Ho-Geun
authors.initials: HG
authors.lastname: Yoon
authors.affiliation: Division of Food and Nutritional Science, Chonnam National University, Gwangju, Republic of Korea.|Research Institute for Human Ecology, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Jeongjin
authors.initials: J
authors.lastname: Park
authors.affiliation: Division of Food and Nutritional Science, Chonnam National University, Gwangju, Republic of Korea.|Research Institute for Human Ecology, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Yanghee
authors.initials: Y
authors.lastname: You
authors.affiliation: Department of Biofood Analysis, Korea Bio Polytechnic, Nonsan, Chungnam, Republic of Korea.
authors.forename: Kyungmi
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Food and Nutrition, University of Suwon, Suwon, Republic of Korea.
authors.forename: Yoo-Hyun
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Kyung-Chul
authors.initials: KC
authors.lastname: Choi
authors.affiliation: Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea.
authors.forename: Jeongmin
authors.initials: J
authors.lastname: Lee
authors.affiliation: Division of Food and Nutritional Science, Chonnam National University, Gwangju, Republic of Korea; wjjun@chonnam.ac.kr.|Research Institute for Human Ecology, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Woojin
authors.initials: W
authors.lastname: Jun
keywords: Curcuma longa; adipogenesis; anti-obesity; high-fat diet; lipolysis
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