title: [Narrow band imaging-assisted holmium laser resection reduced the recurrence rate of non-muscle invasive bladder cancer: a prospective, randomized controlled study].
abstract: OBJECTIVE
  To compare the differential effects of narrow band imaging (NBI)-assisted holmium laser with transurethral resection on the 1-year recurrence rate of non-muscle invasive bladder cancer (NMIBC), and to evaluate the clinical values of NBI-assisted holmium laser resection for NMIBC (NBI-HoLRBt).
  
  
  METHODS
  During the period of February 2013 to February 2014, 178 cases of NMIBC were randomly divided into NBI-HoLRBt group and white light imaging (WLI) assisted transurethral resection of bladder tumor (WLI-TURBt) group. In NBI-HoLRBt, all suspicious lesion identified by either WLI or NBI were resected with WLI and in NBI mode for lesion only visible with NBI. At the end of the procedure, a NBI cystoscopic examination was performed to assess the margins of the resection areas and to identify eventual residual lesions. In WLI-TURBt group, only WLI and TURBt were applied. All patients underwent routine follow-up with WLI and NBI cystoscopy supplemented with cytology every 3 month. The recurrence risk of patients with NMIBC subjected to either NBI-HoLRBt or WLI-TURBt was compared at 3 and 12 month.
  
  
  RESULTS
  The 3-month and 1-year recurrence rate was 18.48% (17/92) and 38.04% (35/92) respectively in the WLI-TURBt group, it was 5.81% (5/86) and 18.60% (16/86) in the NBI-HoLRBt group (both P<0.05). In addition, the in situ recurrence rate was less in the NBI-HoLRBt than WLI-TURBt group (2.33% vs 14.13%, P<0.05).
  
  
  CONCLUSIONS
  NBI-assisted holmium laser resection of bladder tumor can reduce the 3-month and 1-year recurrence risk of NMIBC and should be considered a valuable clinical therapeutic method for NMIBC.
authors.affiliation: Department of Urology, Second Hospital of Shandong University, Shandong University Urologic Institute, Jinan 250033, China.
authors.forename: Tianjia
authors.initials: T
authors.lastname: Ma
authors.affiliation: Department of Urology, Second Hospital of Shandong University, Shandong University Urologic Institute, Jinan 250033, China.
authors.forename: Wenzhen
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Urology, Second Hospital of Shandong University, Shandong University Urologic Institute, Jinan 250033, China.
authors.forename: Zhaoqun
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Urology, Second Hospital of Shandong University, Shandong University Urologic Institute, Jinan 250033, China.
authors.forename: Guangfeng
authors.initials: G
authors.lastname: Shao
authors.affiliation: Department of Urology, Second Hospital of Shandong University, Shandong University Urologic Institute, Jinan 250033, China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Urology, Second Hospital of Shandong University, Shandong University Urologic Institute, Jinan 250033, China.
authors.forename: Junjia
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Urology, Second Hospital of Shandong University, Shandong University Urologic Institute, Jinan 250033, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Urology, Second Hospital of Shandong University, Shandong University Urologic Institute, Jinan 250033, China; Email: zyb@sdu.edu.cn.
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D003558:Cystoscopy; D006695:Holmium; D006801:Humans; D053844:Lasers, Solid-State; D008027:Light; D062048:Narrow Band Imaging; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D001749:Urinary Bladder Neoplasms
chemical_list: D006695:Holmium