title: Sliding Keratoplasty Followed by Transepithelial Iontophoresis Collagen Cross-linking for Pellucid Marginal Degeneration.
abstract: OBJECTIVE
  To describe the changes in visual acuity and topographic analysis in a patient affected by advanced pellucid marginal degeneration (PMD).
  
  
  METHODS
  A 59-year-old woman with bilateral PMD who was contact lens intolerant was treated by sliding keratoplasty before and 3 months after transepithelial (epi-on) iontophoresis collagen cross-linking (I-CXL) in one eye. Corrected distance visual acuity (CDVA), spherical equivalent and cylinder refraction, corneal topography, ultrasound pachymetry, and endothelial cell count were assessed at baseline and up to 12 months postoperatively.
  
  
  RESULTS
  After 1 year of follow-up, CDVA increased from 20/200 to 20/50 and the videokeratographic patterns significantly improved. Endothelial cell counts did not change significantly (P > .05).
  
  
  CONCLUSIONS
  Sliding keratoplasty combined with I-CXL was safe and effective in the treatment of advanced PMD.
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Spadea
authors.forename: Giorgia
authors.initials: G
authors.lastname: Maraone
authors.forename: Carlo
authors.initials: C
authors.lastname: Cagini
mesh_terms: D003094:Collagen / Q000378:metabolism*; D003317:Corneal Dystrophies, Hereditary / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D003319:Corneal Stroma / Q000378:metabolism; D019781:Corneal Topography; D003432:Cross-Linking Reagents; D005260:Female; D006801:Humans; D007478:Iontophoresis / Q000379:methods*; D015948:Keratoplasty, Penetrating / Q000379:methods*; D008875:Middle Aged; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012256:Riboflavin / Q000627:therapeutic use; D013536:Suture Techniques; D014466:Ultraviolet Rays; D014792:Visual Acuity / Q000502:physiology
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin