title: [Clinical and high-resolution computed tomography characteristics of the welder's pneumoconiosis].
abstract: OBJECTIVE
  To investigate the clinical and high-resolution computed tomography (HRCT) features of the welder's pneumoconiosis.
  
  
  METHODS
  A total of 10 patients diagnosed by bronchoscopy and pathology from January 2010 to January 2015 in Nanjing Drum Tower Hospital were recruited in this study, and the clinical manifestations, pulmonary function tests, pathology and HRCT data were collected and analyzed retrospectively.
  
  
  RESULTS
  Ten patients all had welder's occupational history for 5-30 years, with the main clinical manifestations of cough, sputum production, chest tightness and other symptoms. And the ratio of forced expiratory volume in one second and forced vital capacity (FEV1/FVC) of 4 patients was lower than 75.0% in the pulmonary function tests. Transbronchial lung biopsy specimen showed numerous hemosiderin-laden macrophages within the alveolar space, associated with positive iron staining. In welder's pneumoconiosis, small centrilobular nodules (10 cases) were frequently seen on HRCT in bilateral lung fields, with branching linear structures or the tree buds like shadows in 7 cases; 3 patients also showed areas of ground-glass attenuation. And the patients were misdiagnosed as tuberculosis (1/10), interstitial pneumonia (3/10), allergic alveolitis (1/10), diffuse lung disease (2/10), and vasculitis (1/10).
  
  
  CONCLUSIONS
  Clinical manifestations of welder's pneumoconiosis are not specific; small centrilobular nodules are frequently seen on HRCT, with linear opacities or tree bud-like shadows.
authors.affiliation: Department of Respiratory Medicine, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Jinghong
authors.initials: J
authors.lastname: Dai
authors.forename: Liyun
authors.initials: L
authors.lastname: Miao
authors.forename: Min
authors.initials: M
authors.lastname: Cao
authors.forename: Mei
authors.initials: M
authors.lastname: Huang
authors.forename: Fanqing
authors.initials: F
authors.lastname: Meng
authors.affiliation: Email: caihourong2013@163.com.
authors.forename: Hourong
authors.initials: H
authors.lastname: Cai
mesh_terms: D000542:Alveolitis, Extrinsic Allergic; D001999:Bronchoscopy; D006801:Humans; D008168:Lung; D009784:Occupational Diseases; D011009:Pneumoconiosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014896:Welding