title: Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study.
abstract: BACKGROUND
  Several epidemiological studies have determined the associations between coffee intake level and skin cancer risk; however, the results were not yet conclusive. Herein, we conducted a systematic review and meta-analysis of the cohort and case-control studies for the association between coffee intake level and malignant melanoma (MM) risk.
  
  
  METHODS
  Studies were identified through searching the PubMed and MEDLINE databases (to November, 2015). Study-specific risk estimates were pooled under the random-effects model.
  
  
  RESULTS
  Two case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases) were identified. For caffeinated coffee, the pooled relative risk (RR) of MM was 0.81 [95% confidential interval (95% CI) = 0.68-0.97; P-value for Q-test = 0.003; I2 = 63.5%] for those with highest versus lowest quantity of intake. In the dose-response analysis, the RR of MM was 0.955 (95% CI = 0.912-0.999) for per 1 cup/day increment of caffeinated coffee consumption and linearity dose-response association was found (P-value for nonlinearity = 0.326). Strikingly, no significant association was found between the decaffeinated coffee intake level and MM risk (pooled RR = 0.92, 95% CI = 0.81-1.05; P-value for Q-test = 0.967; I2 = 0%; highest versus lowest quantity of intake).
  
  
  CONCLUSIONS
  This meta-analysis suggested that caffeinated coffee might have chemo-preventive effects against MM but not decaffeinated coffee. However, larger prospective studies and the intervention studies are warranted to confirm these findings.
authors.affiliation: Nantong Tumor Hospital, Nantong Pingchao town, Tong yang Rd. 30, 226361, Jiangsu province, China.
authors.forename: Jibin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Nantong Tumor Hospital, Nantong Pingchao town, Tong yang Rd. 30, 226361, Jiangsu province, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Shen
authors.affiliation: Nantong Tumor Hospital, Nantong Pingchao town, Tong yang Rd. 30, 226361, Jiangsu province, China.
authors.forename: Minxin
authors.initials: M
authors.lastname: Shi
authors.affiliation: Nantong Tumor Hospital, Nantong Pingchao town, Tong yang Rd. 30, 226361, Jiangsu province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Cai
mesh_terms: D002110:Caffeine; D003069:Coffee; D004327:Drinking Behavior; D006801:Humans; D008545:Melanoma / Q000209:etiology*; D012307:Risk Factors; D040242:Risk Reduction Behavior; D012878:Skin Neoplasms / Q000209:etiology*
chemical_list: D003069:Coffee; D002110:Caffeine
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