title: [Effects of mild hypothemia on hemodynamics of systemic and renal of dog with septic shock].
abstract: OBJECTIVE
  To explore the effects of mild hypothemia on hemodynamics of systemic and renal of dog with septic shock.
  
  
  METHODS
  40 healthy dogs were randomly and evenly divided into the normal temperature non-infected group (NTNS), normal temperature infected group (NTS), hypothermia non-infected group (MHNS) and hypothermia infected group (MHS). NTS and MHS were pumped through the femoral vein of Escherichia coli (E.coli 1 × 10⁹ cfu/ml) by 0.5 ml·kg⁻¹·h⁻¹, producting septic shock model with high-power cycle. Combining with blood pump devices and low temperature thermostat bath, the MHNS and MHS implemented extracorporeal blood cooling method to maintain the blood in temperature (33 ± 1) °C. 0, 24, 48, 72 h point, tested specimens from femoral vein for renal function. In the 0-72 h. Pulse indicates the continuous cardiac output monitor (PiCCO) monitored systemic hemodynamics on each time point. In the 0-72 h, color Doppler ultrasound (CDFI) measured renal hemodynamic on each time point.
  
  
  RESULTS
  There was an increase of SBP (P<0.05), SVR [(2 415 ± 651) dyn·s·cm⁻⁵ vs (1 613 ± 223) dyn·s·cm⁻⁵, P=0.01] and RI (P=0.04) in the MHS group comparing with the NTS group from 24 to 72 h. CO [(3.58 ± 0.44) L/min vs (4.18 ± 0.60) L/min, P=0.04], HR and PSV was decreased in the MHS group. BUN [(8.6 ± 1.6) mmol/L vs (21.2 ± 4.8) mmol/L, P<0.01] and Scr [(167.6 ± 31.2) µmol/L vs (383.8 ± 35.2) µmol/L, P<0.01] was decreased in MHS group comparing with the NTS group. There was a positively correlation between CO and PSV in the canine model of septic shock (P<0.01); and CO was negatively correlated with RI (P<0.01).
  
  
  CONCLUSIONS
  In this canine model of septic shock, hypothermia can stable systemic and renal hemodynamics, and improve kidney function.
authors.affiliation: Department of Surgical Intensive Care Unit, Dalian Municipal Central Hospital, Dalian 116033, China.
authors.forename: Sibo
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Surgical Intensive Care Unit, Dalian Municipal Central Hospital, Dalian 116033, China.
authors.forename: Jinjie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Surgical Intensive Care Unit, Dalian Municipal Central Hospital, Dalian 116033, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Gao
authors.affiliation: Department of Surgical Intensive Care Unit, Dalian Municipal Central Hospital, Dalian 116033, China.
authors.forename: Song
authors.initials: S
authors.lastname: Cui
authors.affiliation: Department of Surgical Intensive Care Unit, Dalian Municipal Central Hospital, Dalian 116033, China.
authors.forename: Hengjie
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Surgical Intensive Care Unit, Dalian Municipal Central Hospital, Dalian 116033, China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Surgical Intensive Care Unit, Dalian Municipal Central Hospital, Dalian 116033, China.
authors.forename: Yichao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Surgical Intensive Care Unit, Dalian Municipal Central Hospital, Dalian 116033, China; Email: lsb3385@sina.com.
authors.forename: Rongli
authors.initials: R
authors.lastname: Yang
mesh_terms: D000818:Animals; D002302:Cardiac Output; D004285:Dogs; D006439:Hemodynamics; D007668:Kidney; D012772:Shock, Septic