title: Tourniquet Use During Knee Replacement Surgery May Contribute to Muscle Atrophy in Older Adults.
abstract: Muscle atrophy after total knee arthroplasty (TKA) occurs at a rate of 1% per day for the first 2 wk. Our hypothesis is that tourniquet-induced ischemia-reperfusion injury occurring during TKA influences metabolism and may contribute to atrophy. Identifying pathways that are upregulated during this critical "14-d window" after surgery may help us delineate therapeutic approaches to avoid muscle loss.
authors.affiliation: Department of Human Physiology, University of Oregon, Eugene, OR.
authors.forename: Hans C
authors.initials: HC
authors.lastname: Dreyer
mesh_terms: D000367:Age Factors; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D002470:Cell Survival; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism; D032342:Muscle Cells / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism; D009133:Muscular Atrophy / Q000209:etiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000209:etiology* / Q000473:pathology; D015398:Signal Transduction; D013312:Stress, Physiological; D013997:Time Factors; D014111:Tourniquets / Q000009:adverse effects*
chemical_list: D009124:Muscle Proteins; D017382:Reactive Oxygen Species
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