title: TRPV currents and their role in the nociception and neuroplasticity.
abstract: Transient receptor potential channels sensitive to vanilloids (TRPVs) are group of ion channels which are sensitive to various tissue damaging signals and their activation is generally perceived as pain. Therefore, they are generally named as nociceptors. Understanding their activation and function as well as their interaction with intracellular pathways is crucial for the development of pharmacological interference in order to reduce pain perception. The current review summarizes basic facts in regard to TRPV and discusses their relevance in the sensing of (pain-) signals and their intracellular processing, focussing on their modulation of the intracellular calcium ([Ca(2+)]i) signal. Furthermore we discuss the basic mechanisms how the modification of [Ca(2+)]i through TRPV might induce long-term-potentiation (LTP) or long-term- depression (LTD) and from "memories" of pain. Understanding of these mechanisms is needed to localize the best point of interference for pharmacological treatment. Therefore, high attention is given to highlight physiological and pathological processes and their interaction with significant modulators and their roles in neuroplasticity and pain modulation.
authors.affiliation: Weill Cornell Medicine in Qatar, Qatar Foundation - Education City, Doha, Qatar.
authors.forename: Noothan Jyothi
authors.initials: NJ
authors.lastname: Satheesh
authors.affiliation: Division of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women's University, Tokyo, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Uehara
authors.affiliation: Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: Julia
authors.initials: J
authors.lastname: Fedotova
authors.affiliation: Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Pohanka
authors.affiliation: Weill Cornell Medicine in Qatar, Qatar Foundation - Education City, Doha, Qatar.
authors.forename: Dietrich
authors.initials: D
authors.lastname: Büsselberg
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic; Laboratory of Structural Biology and Proteomics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; 2(nd) Department of Internal Medicine, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: kruzliakpeter@gmail.com.
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D020013:Calcium Signaling; D006801:Humans; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D059225:Nociception / Q000502:physiology*; D015398:Signal Transduction; D050916:TRPV Cation Channels / Q000378:metabolism / Q000502:physiology*
chemical_list: D050916:TRPV Cation Channels
keywords: Currents; Neuroplasticity; Nociception; TRPV receptors; Therapy