title: Association of GSTs polymorphisms with risk of gestational diabetes mellitus.
abstract: We conducted a case-control study to investigate the association between GSTM1, GSTT1 and GSTP1 IIe105Val polymorphisms and development of gestational diabetes mellitus in a Chinese population. A total of 320 patients with gestational diabetes mellitus and 358 pregnancy subjects were consecutively collected between January 2013 and December 2014. Genotyping for detection of GSTM1, GSTT1 and GSTP1 IIe105Val was conducted by using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphisms) method. By Fisher's exact test, we found that the genotype distributions of GSTP1 IIe105Val were in line with the Hardy-Weinberg equilibrium in control subjects (P=0.57). By Chi-square test, we found significant differences in the genotype distributions of GSTM1 (χ(2)=11.49, P=0.001) and GSTT1 (χ(2)=18.50, P<0.001). Using unconditional logistic analysis, individuals carrying the null genotypes of GSTM1 and GSTT1 were associated with an increased risk of gestational diabetes mellitus when compared with the present genotype, and the adjusted Ors (95% CI) were 1.71 (1.24-2.36) and 2.00 (1.44-2.79), respectively. However, the GSTP1 IIe105Val polymorphism was not associated with an elevated risk of gestational diabetes mellitus. In conclusion, we suggest that the GSTM1 null genotype and GSTT1 null genotype are correlated with an increased risk of gestational diabetes mellitus in a Chinese population.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, China.
authors.forename: Shaoru
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Zhai
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Hai
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Cao
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, China.
authors.forename: Qinggui
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human
keywords: GSTM1; GSTP1 IIe105Val; GSTT1; gestational diabetes mellitus; polymorphism
references.citation: PLoS One. 2015;10(6):e0128901
references.pmid: 26039078
references.citation: Diabetes Care. 2001 Jul;24(7):1151-5
references.pmid: 11423494
references.citation: Zhonghua Fu Chan Ke Za Zhi. 2014 Aug;49(8):588-93
references.pmid: 25354859
references.citation: BJOG. 2008 Jul;115(8):969-78
references.pmid: 18651880
references.citation: Nature. 2003 Jan 30;421(6922):486-8
references.pmid: 12556872
references.citation: Chem Biol Interact. 1998 Apr 24;111-112:351-64
references.pmid: 9679566
references.citation: West Indian Med J. 2014 Aug;63(4):300-6
references.pmid: 25429472
references.citation: Diabetes Care. 2008 Dec;31(12):2288-93
references.pmid: 18809630
references.citation: Toxicol Lett. 2000 Mar 15;112-113:357-63
references.pmid: 10720752
references.citation: Diabetes Care. 2008 Jan;31 Suppl 1:S55-60
references.pmid: 18165338
references.citation: Diabetes Care. 2007 Jul;30 Suppl 2:S251-60
references.pmid: 17596481
references.citation: Diabet Med. 2004 Feb;21(2):103-13
references.pmid: 14984444
references.citation: Annu Rev Pharmacol Toxicol. 2005;45:51-88
references.pmid: 15822171
references.citation: Diabetes Care. 2007 Aug;30(8):2070-6
references.pmid: 17416786
references.citation: Ann Hum Biol. 2015;42(5):461-9
references.pmid: 25357227
references.citation: Front Pediatr. 2015 May 05;3:34
references.pmid: 26000264
references.citation: J Matern Fetal Neonatal Med. 2013 Mar;26(4):412-6
references.pmid: 23035769
references.citation: FASEB J. 1992 Jan 6;6(2):745-8
references.pmid: 1537465
references.citation: Diabetes Care. 2006 Jul;29(7):1713-4
references.pmid: 16801613
references.citation: Meta Gene. 2014 Apr 17;2:299-306
references.pmid: 25606412
references.citation: PLoS One. 2013;8(10):e76262
references.pmid: 24098457
references.citation: Iran J Med Sci. 2015 Mar;40(2):170-4
references.pmid: 25821298
references.citation: Nature. 2003 Jan 23;421(6921):436-40
references.pmid: 12540918
references.citation: Nature. 2003 Feb 20;421(6925):859-63
references.pmid: 12594517
references.citation: Iran J Basic Med Sci. 2014 May;17(5):351-6
references.pmid: 24967064
references.citation: Diabetes Care. 2005 Mar;28(3):579-84
references.pmid: 15735191
references.citation: Clin Biochem. 2014 May;47(7-8):574-7
references.pmid: 24685594