title: Opiate Analgesics and the Perioperative Management of Patients with Obstructive Sleep Apnea.
abstract: As the rate of obesity and subsequently obstructive sleep apnea (OSA) continue to rise in North America and prescriptions for narcotic analgesics number in the tens of millions, it has become increasingly important to understand the interaction between OSA and opiate analgesics. Understanding the mechanism of action of opiate analgesics and the pathophysiology of OSA can help medical professionals understand the unique risks associated with pain management in this population of patients.
authors.forename: Quinn L
authors.initials: QL
authors.lastname: Johnson
authors.forename: Anthony
authors.initials: A
authors.lastname: Netzer
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000758:Anesthesia / Q000592:standards*; D002648:Child; D003061:Codeine / Q000378:metabolism*; D006801:Humans; D019990:Perioperative Care / Q000592:standards*; D020181:Sleep Apnea, Obstructive / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery
chemical_list: D000701:Analgesics, Opioid; D003061:Codeine
references.citation: Clin J Pain. 2010 Jan;26 Suppl 10:S3-9
references.pmid: 20026962
references.citation: Nat Sci Sleep. 2013 Sep 25;5:109-23
references.pmid: 24109201
references.citation: Forensic Sci Int. 2014 Jun;239:50-6
references.pmid: 24747667
references.citation: Anesthesiology. 2008 May;108(5):812-21
references.pmid: 18431116
references.citation: Chest. 2006 Sep;130(3):902-5
references.pmid: 16963693
references.citation: Am J Respir Crit Care Med. 2002 May 1;165(9):1217-39
references.pmid: 11991871
references.citation: J Clin Sleep Med. 2011 Oct 15;7(5):459-65B
references.pmid: 22003340
references.citation: Clin Pharmacol Ther. 2014 Apr;95(4):376-82
references.pmid: 24458010
references.citation: Otolaryngol Head Neck Surg. 2014 Nov;151(5):709-13
references.pmid: 25164469
references.citation: Anesthesiology. 2009 Apr;110(4):928-39
references.pmid: 19293704
references.citation: Anesth Analg. 2014 Jun;118(6):1276-83
references.pmid: 23842193
references.citation: Support Care Cancer. 2005 Mar;13(3):153-9
references.pmid: 15611852
references.citation: Chest. 2007 Jul;132(1):325-37
references.pmid: 17625094
references.citation: J Am Geriatr Soc. 2010 Jul;58(7):1353-69
references.pmid: 20533971
references.citation: Proc Am Thorac Soc. 2008 Feb 15;5(2):136-43
references.pmid: 18250205