title: The role of oxidative stress on breast cancer development and therapy.
abstract: Reactive oxygen species (ROS) are produced by both enzymatic and non-enzymatic systems within eukaryotic cells and play important roles in cellular physiology and pathophysiology. Although physiological concentrations are crucial for ensuring cell survival, ROS overproduction is detrimental to cells, and considered key-factors for the development of several diseases, such as neurodegenerative diseases, cardiovascular disorders, and cancer. Cancer cells are usually submitted to higher ROS levels that further stimulate malignant phenotype through stimulus to sustained proliferation, death evasion, angiogenesis, invasiveness, and metastasis. The role of ROS on breast cancer etiology and progression is being progressively elucidated. However, less attention has been given to the development of redox system-targeted strategies for breast cancer therapy. In this review, we address the basic mechanisms of ROS production and scavenging in breast tumor cells, and the emerging possibilities of breast cancer therapies targeting ROS homeostasis.
authors.affiliation: Laboratório de Radiobiologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS - Bloco G - Subsolo - Sala G0-031, Cidade Universitária - Ilha do Fundão, 21941-902, Rio de Janeiro, RJ, Brazil.|Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Fabio
authors.initials: F
authors.lastname: Hecht
authors.affiliation: Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Carolina F
authors.initials: CF
authors.lastname: Pessoa
authors.affiliation: Laboratório de Radiobiologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS - Bloco G - Subsolo - Sala G0-031, Cidade Universitária - Ilha do Fundão, 21941-902, Rio de Janeiro, RJ, Brazil.
authors.forename: Luciana B
authors.initials: LB
authors.lastname: Gentile
authors.affiliation: Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Doris
authors.initials: D
authors.lastname: Rosenthal
authors.affiliation: Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Denise P
authors.initials: DP
authors.lastname: Carvalho
authors.affiliation: Laboratório de Radiobiologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS - Bloco G - Subsolo - Sala G0-031, Cidade Universitária - Ilha do Fundão, 21941-902, Rio de Janeiro, RJ, Brazil. rodrigof@biof.ufrj.br.
authors.forename: Rodrigo S
authors.initials: RS
authors.lastname: Fortunato
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D049109:Cell Proliferation / Q000235:genetics; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species
keywords: Antioxidant enzymes; Breast cancer; Oxidative stress; Reactive oxygen species
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