title: [ROLE OF BIOMARKERS IN ESTIMATION OF RENAL TUBULOINTERSTITIAL TISSUE DAMAGE IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS].
abstract: OBJECTIVE
  to investigate the relationship between the levels of NGAL and IL-18 in.blood, urine and clinical, morphological parameters reflecting renal tubulointerstitial tissue damage (TTD) in patients with chronic glomerulonephritis (CGN).
  
  
  METHODS
  We examined 81 patients with CGN. Patients were divided into 2 groups according to the presence of arterial hypertension (AH). Levels of NGAL and IL-18 in blood and urine were determined by the immuno-enzymic method. Data of renal morphological study were used for the analysis of TTD.
  
  
  RESULTS
  In patients with CGN and AH we observed more pronounced morphological changes of renal TTD, what coincide with higher levels of NGAL and IL-18 in blood and urine. We found correlations between markers and morphological changes, what allow to use NGAL in blood and urine, IL-18 in blood to estimate renal TTD in CGN.
  
  
  CONCLUSIONS
  NGAL in blood most accurately reflects interstitial fibrosis (IF) and tubular basement membrane changes; NGAL in urine--tubular epithelium dystrophy. IL-18 in blood is an indicator of dystrophy and necrosis of the tubular epithelium, IF.
authors.forename: O V
authors.initials: OV
authors.lastname: Kraydaschenko
authors.forename: A V
authors.initials: AV
authors.lastname: Abramov
authors.forename: M A
authors.initials: MA
authors.lastname: Dolinnaya
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002908:Chronic Disease; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000652:urine; D020382:Interleukin-18 / Q000097:blood* / Q000652:urine; D047908:Intracellular Signaling Peptides and Proteins; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008297:Male; D008840:Microfilament Proteins; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood / Q000652:urine*; D009395:Nephritis, Interstitial / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000652:urine; D019459:Urothelium / Q000378:metabolism / Q000473:pathology
chemical_list: D015415:Biomarkers; C476824:GCSAM protein, human; C000589760:IL18 protein, human; D020382:Interleukin-18; D047908:Intracellular Signaling Peptides and Proteins; D008840:Microfilament Proteins; D009363:Neoplasm Proteins