title: Long-term prognostic significance of admission plateletcrit values in patients with non-ST elevation myocardial infarction.
abstract: The plateletcrit has been investigated as a new predictor of cardiovascular risk. The objective of our study was to investigate the role of admission plateletcrit in predicting long-term cardiovascular mortality in patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI). We enrolled 296 patients with NSTEMI (mean age 59.2 ± 11.8 years; 228 men, 68 women) in this study. The study population was divided into tertiles on the basis of admission plateletcrit values. A high plateletcrit (n = 98) was defined as a value in the upper third tertile (plateletcrit >0.23), and a low plateletcrit (n = 198) was defined as any value in the lower two tertiles (plateletcrit ≤0.23). The median follow-up time was 38 months. In multivariate analyses, a significant association was noted between high plateletcrit values and the adjusted risk of long-term mortality (odds ratio = 12.15, 95% confidence interval = 1.78-82.77; P < 0.001). In the Kaplan-Meier survival analysis, the long-term mortality rate was 20.4% in the high plateletcrit group versus 4.5% in the low plateletcrit group (P < 0.001). Long-term major advanced cardiac events (MACE), hospitalization for heart failure and reinfarction were significantly higher in patients with high plateletcrit. Admission plateletcrit is a strong and independent predictor of long-term cardiovascular mortality in patients with NSTEMI.
authors.affiliation: aDepartment of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital bDepartment of Cardiology, Bezm-i Alem Vakif University, School of Medicine, Istanbul, cDepartment of Cardiology, Mustafakemalpasa State Hospital, Bursa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
authors.forename: Huseyin
authors.initials: H
authors.lastname: Uyarel
authors.forename: Ozgur
authors.initials: O
authors.lastname: Akgul
authors.forename: Emre
authors.initials: E
authors.lastname: Akkaya
authors.forename: Ozgur
authors.initials: O
authors.lastname: Surgit
authors.forename: Huseyin Altug
authors.initials: HA
authors.lastname: Cakmak
authors.forename: Hamdi
authors.initials: H
authors.lastname: Pusuroglu
authors.forename: Turab
authors.initials: T
authors.lastname: Yakisan
authors.forename: Serkan
authors.initials: S
authors.lastname: Aslan
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Eksik
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015999:Multivariate Analysis; D000072658:Non-ST Elevated Myocardial Infarction / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D015415:Biomarkers