title: Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo.
abstract: Whether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their connectivity upon regeneration of their major input. H3 horizontal cells (HCs) normally avoid red and green cones, and prefer ultraviolet over blue cones. Upon ablation of the major (ultraviolet) input, H3 HCs do not immediately increase connectivity with other cone types. Instead, H3 dendrites retract and re-extend to contact new ultraviolet cones. But, if regeneration is delayed or absent, blue-cone synaptogenesis increases and ectopic synapses are made with red and green cones. Thus, cues directing synapse specificity can be maintained following input loss, but only within a limited time period. Further, we postulate that signals from the major input that shape the H3 HC's wiring pattern during development persist to restrict miswiring after damage.
authors.affiliation: Department of Biological Structure, University of Washington, 1959 NE Pacific Street, Box 357420, Seattle, Washington 98195, USA.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshimatsu
authors.affiliation: Department of Biological Structure, University of Washington, 1959 NE Pacific Street, Box 357420, Seattle, Washington 98195, USA.
authors.forename: Florence D
authors.initials: FD
authors.lastname: D'Orazi
authors.affiliation: Department of Biological Structure, University of Washington, 1959 NE Pacific Street, Box 357420, Seattle, Washington 98195, USA.
authors.forename: Clare R
authors.initials: CR
authors.lastname: Gamlin
authors.affiliation: Department of Biological Structure, University of Washington, 1959 NE Pacific Street, Box 357420, Seattle, Washington 98195, USA.
authors.forename: Sachihiro C
authors.initials: SC
authors.lastname: Suzuki
authors.affiliation: Department of Biological Structure, University of Washington, 1959 NE Pacific Street, Box 357420, Seattle, Washington 98195, USA.|Department of Physiology and Developmental Biology, Brigham Young University, 3048 LSB, Provo, Utah 84602, USA.
authors.forename: Arminda
authors.initials: A
authors.lastname: Suli
authors.affiliation: Department of Biochemistry, University of Washington, 1705 NE Pacific Street, Box 357350, Seattle, Washington 98195, USA.
authors.forename: David
authors.initials: D
authors.lastname: Kimelman
authors.affiliation: Department of Biological Structure, University of Washington, 1959 NE Pacific Street, Box 357420, Seattle, Washington 98195, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Raible
authors.affiliation: Department of Biological Structure, University of Washington, 1959 NE Pacific Street, Box 357420, Seattle, Washington 98195, USA.
authors.forename: Rachel O
authors.initials: RO
authors.lastname: Wong
mesh_terms: D000818:Animals; D003463:Cues; D003712:Dendrites / Q000502:physiology*; D007150:Immunohistochemistry; D018613:Microscopy, Confocal; D061848:Optical Imaging; D012038:Regeneration / Q000502:physiology*; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology*; D051248:Retinal Horizontal Cells / Q000502:physiology*; D055351:Retinal Neurons / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D014466:Ultraviolet Rays; D015027:Zebrafish
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