title: Site-Specific Surface Functionalization of Gold Nanorods Using DNA Origami Clamps.
abstract: Precise control over surface functionalities of nanomaterials offers great opportunities for fabricating complex functional nanoarchitectures but still remains challenging. In this work, we successfully developed a novel strategy to modify a gold nanorod (AuNR) with specific surface recognition sites using a DNA origami clamp. AuNRs were encapsulated by the DNA origami through hybridization of single-stranded DNA on the AuNRs and complementary capture strands inside the clamp. Another set of capture strands on the outside of the clamp create the specific recognition sites on the AuNR surface. By means of this strategy, AuNRs were site-specifically modified with gold nanoparticles at the top, middle, and bottom of the surface, respectively, to construct a series of well-defined heterostructures with controlled "chemical valence". Our study greatly expands the utility of DNA origami as a tool for building complex nanoarchitectures and represents a new approach for precise tailoring of nanomaterial surfaces.
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
authors.forename: Chenqi
authors.initials: C
authors.lastname: Shen
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Lan
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
authors.forename: Xuxing
authors.initials: X
authors.lastname: Lu
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Emory School of Medicine , Atlanta, Georgia 30322, United States.
authors.forename: Travis A
authors.initials: TA
authors.lastname: Meyer
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
authors.forename: Weihai
authors.initials: W
authors.lastname: Ni
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Emory School of Medicine , Atlanta, Georgia 30322, United States.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Ke
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
authors.forename: Qiangbin
authors.initials: Q
authors.lastname: Wang
mesh_terms: D004277:DNA, Single-Stranded / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D013499:Surface Properties
chemical_list: D004277:DNA, Single-Stranded; D006046:Gold