title: Comparative systems genetics view of endometriosis and uterine leiomyoma: Two sides of the same coin?
abstract: Endometriosis (EM) and uterine leiomyoma (UL) are two most frequent benign tumors of monoclonal origin affecting about 30% of all women in their reproductive age. Modern molecular technologies have made a tremendous impact in understanding both disorders. Here is the first comparative analysis of molecular mechanisms underlying development of EM and UL as it looks from the platform of systems genetics. Similarities and differences of EM and UL at their incipient stages are enlightened with special emphasis on their gene networks, gene expression, and epigenetic regulation, of pathologic development. The analysis substantiates a new hypothesis postulating tumors as outgrowths of the stem cells with mesenchymal commitment lineage (mSC) which migrate from the endometrium/myometrium junctional zone of the uterus. Comparative analysis has revealed basic similarities of molecular pathogenesis of EM and UL suggesting molecular syntropy of both disorders. Peculiarities of the epigenetic landscape determining development of mSC may explain the existence of different clinical forms of EM and UL as well as their unique clinical manifestation. Some perspectives for practical and scientific application in EM and UL studies of this new hypothesis are outlined.
authors.affiliation: a D.O. Ott Research Institute of Obstetrics , Gynecology and Reproductology , Saint-Petersburg , Russian Federation.
authors.forename: Vladislav S
authors.initials: VS
authors.lastname: Baranov
authors.affiliation: a D.O. Ott Research Institute of Obstetrics , Gynecology and Reproductology , Saint-Petersburg , Russian Federation.
authors.forename: Tatyana E
authors.initials: TE
authors.lastname: Ivaschenko
authors.affiliation: a D.O. Ott Research Institute of Obstetrics , Gynecology and Reproductology , Saint-Petersburg , Russian Federation.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Yarmolinskaya
mesh_terms: D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004715:Endometriosis / Q000235:genetics* / Q000473:pathology; D044127:Epigenesis, Genetic; D005260:Female; D053263:Gene Regulatory Networks; D006801:Humans; D007889:Leiomyoma / Q000235:genetics* / Q000473:pathology; D059630:Mesenchymal Stem Cells / Q000473:pathology; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology
keywords: Endometriosis; epigenetic landscape; syntropy; systemic genetics; uterine leiomyoma