title: Quantitative assessment of the association between Fas/FasL gene polymorphism and susceptibility to esophageal carcinoma in a north Chinese population.
abstract: The case-control study aims to investigate the association of Fas and FasL genetic polymorphisms (Fas-670A/G (rs1800682), Fas-1377G/A (rs2234767) and FasL-844T/C (rs763110)) with esophageal carcinoma susceptibility in a north Chinese population. A total of 204 patients with esophageal carcinoma and 248 healthy controls were enrolled from Henan, China and genotyped by the polymerase chain reaction and restriction fragment length polymorphism method. There were no significant differences in distributions of their genotypes frequencies between patients and controls in Fas-670A/G, Fas-1377G/A and FasL-844T/C polymorphisms (P > 0.05). Stratified analysis showed that no significant association was found between esophageal carcinoma and gene polymorphisms of Fas-670 A/G, Fas-1377G/A, and FasL-844T/C (P > 0.05). Genetic polymorphisms in the death pathway genes Fas and FasL were not associated with risk of developing esophageal carcinoma in a north Chinese population.
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Meijuan
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Baohuan
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Du
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Chuanzhen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
authors.forename: Ziping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D019014:fas Receptor / Q000235:genetics*
chemical_list: D053222:Fas Ligand Protein; D019014:fas Receptor
keywords: Esophageal carcinoma; Fas; FasL; polymorphism
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