title: Successful treatment of cytomegalovirus associated hemophagocytic lymphohistiocytosis with the interleukin 1 inhibitor - anakinra.
abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare, frequently under-recognized condition associated with multi-organ failure and very high mortality. A 44-year-old woman was admitted with a 4-day history of fever, headache, delirium, and dyspnea. She progressed rapidly to type 1 respiratory failure and required intubation and mechanical ventilation. Laboratory tests showed pancytopenia, abnormal liver enzyme levels, elevated triglyceride level, and elevated ferritin level. Bone marrow biopsy showed features of HLH. Computed tomography scan showed bilateral consolidation. Bronchoalveolar lavage was positive for cytomegalovirus. She was treated with ganciclovir, methylprednisolone, broad spectrum antibiotics, and cytomegalovirus hyperimmunoglobulin without clinical response. Given the poor prognosis and reports of success in pediatric HLH, anakinra 100 µg subcutaneously daily was commenced. There was rapid defervescence, resolution of delirium, and improvement in gas exchange, leading to complete recovery. This case illustrates successful treatment of HLH associated with cytomegalovirus pneumonitis with the interleukin 1 inhibitor anakinra.
authors.affiliation: The Prince Charles Hospital Brisbane Queensland Australia.
authors.forename: Chandima
authors.initials: C
authors.lastname: Divithotawela
authors.affiliation: Noosa Hospital ICU Noosa Queensland Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Garrett
authors.affiliation: Alfred Hospital Melbourne Victoria Australia.
authors.forename: Glen
authors.initials: G
authors.lastname: Westall
authors.affiliation: The Prince Charles Hospital Brisbane Queensland Australia.
authors.forename: Balu
authors.initials: B
authors.lastname: Bhaskar
authors.affiliation: The Prince Charles Hospital Brisbane Queensland Australia.
authors.forename: Maneesha
authors.initials: M
authors.lastname: Tol
authors.affiliation: The Prince Charles Hospital Brisbane Queensland Australia.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Chambers
keywords: Hemophagocytic lymphohistiocytosis; inflammation; pulmonary; virology
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