title: Analysis of mechanical parameters on the thromboembolism using a patient-specific computational model.
abstract: Ischemic stroke is a major cause of death and long-term disabilities worldwide. In this paper, we aim to represent a comprehensive simulation of the motion of emboli through cerebrovascular network within patient-specific computational model. The model consists of major arteries of the circle of Willis reconstructed from magnetic resonance angiography images, pulsatile flow and emboli with different sizes and material properties. Here, the fluid-structure interactions method was used to simulate the motion of deformable and rigid emboli through cerebral arteries. Hemodynamic changes in the circle of Willis due to the entrance of embolus are observed. The effect of material properties on the distribution ratio and dynamics of motion of the emboli in the cerebral arterial network is also analyzed. Our results reveal that as the rigidity of emboli increases, higher proportion of them tend to enter to the larger arteries (e.g., middle cerebral artery). Scrutinizing the amount of stress acting on the emboli represented in this paper can broaden our understanding of the rheological phenomenon (e.g., lysis or growth of emboli during embolism). The approach of considering different material properties of the thrombus in a patient-specific computational model not only enable us to better understand the roll of biomechanical parameters causing the embolism, but also lead to a better clinical decision making to manage patients with stroke.
authors.affiliation: Biological Fluid Mechanics Research Laboratory, Biomechanics Department, Amirkabir University of Technology, Tehran, Iran.
authors.forename: Farhan
authors.initials: F
authors.lastname: Khodaee
authors.affiliation: Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
authors.forename: Bahman
authors.initials: B
authors.lastname: Vahidi
authors.affiliation: Biological Fluid Mechanics Research Laboratory, Biomechanics Department, Amirkabir University of Technology, Tehran, Iran. nasser@aut.ac.ir.
authors.forename: Nasser
authors.initials: N
authors.lastname: Fatouraee
mesh_terms: D001696:Biomechanical Phenomena; D002536:Cerebral Arteries / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D002941:Circle of Willis / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008954:Models, Biological; D011312:Pressure; D013314:Stress, Mechanical; D013923:Thromboembolism / Q000473:pathology / Q000503:physiopathology*
keywords: Circle of Willis; Fluid–structure interactions; Ischemic stroke; Thromboembolism