title: New blood markers detection technology: A leap in the diagnosis of gastric cancer.
abstract: Gastric cancer (GC) is still one of the malignant tumors with high morbidity and mortality in the world, with a 5-year survival rate of less than 30%. GC is often either asymptomatic or causes only nonspecific symptoms in its early stages, whereas when the symptoms manifest, the cancer has usually reached an advanced stage, which is one of the main causes of its relatively poor prognosis. Hence, the main focus of GC research has been on discovering new tools and technology to predict, screen and diagnose GC at an early stage which would prompt early treatment. With the tremendous advances in the OMICS technology, serum proteomics has been in the limelight of cancer research over the last few decades and has steered the development of several methods helping to understand the mechanisms underlying gastric carcinogenesis, resulting in the identification of a large number of molecular targets such as circulating tumor cells (CTCs), cell free DNA (cfDNA) and cell tumor DNA (ctDNA) and their sub-molecular components such as miRNA, that show great promise as GC biomarkers. In this review, we are underlying the recent breakthroughs about new blood markers technology for GC while scrutinizing the potential clinical use of CTCs, cfDNA, ctDNA and the role of the methylation of their sub-molecular components in the pathogenesis, diagnosis and management of GC.
authors.affiliation: Maneesh K Beeharry, Wen-Tao Liu, Min Yan, Zheng-Gang Zhu, Key Laboratory of Shanghai Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Maneesh K
authors.initials: MK
authors.lastname: Beeharry
authors.affiliation: Maneesh K Beeharry, Wen-Tao Liu, Min Yan, Zheng-Gang Zhu, Key Laboratory of Shanghai Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Liu
authors.affiliation: Maneesh K Beeharry, Wen-Tao Liu, Min Yan, Zheng-Gang Zhu, Key Laboratory of Shanghai Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yan
authors.affiliation: Maneesh K Beeharry, Wen-Tao Liu, Min Yan, Zheng-Gang Zhu, Key Laboratory of Shanghai Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Zheng-Gang
authors.initials: ZG
authors.lastname: Zhu
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000097:blood* / Q000235:genetics; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics; D009363:Neoplasm Proteins / Q000097:blood* / Q000235:genetics; D009360:Neoplastic Cells, Circulating / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype; D011237:Predictive Value of Tests; D011379:Prognosis; D040901:Proteomics / Q000379:methods; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D035683:MicroRNAs; D009363:Neoplasm Proteins
keywords: Biomarkers; Circulating tumor DNA; Circulating tumor cells; Gastric cancer; Methylation; Proteomics
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