title: Innovative perspectives of immunotherapy in head and neck cancer. From relevant scientific rationale to effective clinical practice.
abstract: It is now well established that head and neck cancer carcinogenesis is characterized by genetic instability and several immune defects, leading to unique host-tumor interactions. In such condition, recent improved comprehension and relevant findings could lead to identification of innovative molecular therapeutic targets, achieving considerable clinical and translational research. This review aims to summarize and to highlight most recent and relevant scientific rationale in this era of immunotherapy revival, and to correlate it to the near future clinical practice for the management of this challenging disease.
authors.affiliation: Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles, Boulevard de Waterloo, 121-1000 Brussels, Belgium. Electronic address: yassine.lalami@bordet.be.
authors.forename: Y
authors.initials: Y
authors.lastname: Lalami
authors.affiliation: Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles, Boulevard de Waterloo, 121-1000 Brussels, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Awada
mesh_terms: D063646:Carcinogenesis; D019468:Disease Management; D005544:Forecasting; D042822:Genomic Instability / Q000502:physiology; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods / Q000639:trends; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D057170:Translational Research, Biomedical; D019139:Tumor Escape / Q000187:drug effects
keywords: HPV; Head and neck cancer; Immune system; Immunotherapy; Tumor immune infiltration