title: [Association between retinol-binding protein 4 and coronary artery disease in Chinese: a Meta-analysis].
abstract: OBJECTIVE
  To evaluate the association between retinol-binding protein 4 (RBP4) and coronary artery disease (CAD) in Chinese.
  
  
  METHODS
  A document retrieval was conducted by using retrieval systems, such as PubMed, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) ,CBM, VIP and WanFang Database, to collect the published papers of case-control studies on association between RBP4 and CAD in Chinese up to February, 2015. Data collection and quality assessment were completed by two authors respectively. All the analyses were conducted with software RevMan 5.2.
  
  
  RESULTS
  A total of 10 qualified studies were included in our meta-analysis. The pooled analysis showed that RBP4 might be associated with CAD in Chinese [WMD=7.17 (95% CI: 3.56-10.78) µg/ml, P<0.05]. Clinical subtype specific subgroup analysis showed RBP4 might be also associated with both stable angina pectoris [WMD=4.81 (95% CI: 1.25-8.37) µg/ml, P<0.05 ] and acute myocardial infarction [WMD=13.96 (95% CI: 6.12-21.80) µg/ml, P<0.05]. Age specific subgroup analysis showed the significant association between RBP4 and CAD was only found in patients aged≤65 years [WMD=7.26(95% CI:2.73-11.79) µg/ml, P<0.05]. Sensitivity and publication bias analyses indicated that our results were stable and reliable.
  
  
  CONCLUSIONS
  The meta-analysis suggests that RBP4 might be associated with CAD in Chinese.
authors.affiliation: Department of Clinical Epidemiology and Evidence-based Medicine, Institute of Cardiovascular Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Clinical Epidemiology and Evidence-based Medicine, Institute of Cardiovascular Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Guangxiao
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Clinical Epidemiology and Evidence-based Medicine, Institute of Cardiovascular Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Qiongrui
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Clinical Epidemiology and Evidence-based Medicine, Institute of Cardiovascular Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Clinical Epidemiology and Evidence-based Medicine, Institute of Cardiovascular Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Clinical Epidemiology and Evidence-based Medicine, Institute of Cardiovascular Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, China; Email: sjp562013@126.com.
authors.forename: Jingpu
authors.initials: J
authors.lastname: Shi
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology*; D006801:Humans; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*
chemical_list: C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma