title: Allelopathic Polyketides from an Endolichenic Fungus Myxotrichum SP. by Using OSMAC Strategy.
abstract: Three new polyketides myxotritones A-C (2-4), together with a new natural product 7,8-dihydro-7R,8S-dihydroxy-3,7-dimethyl-2-benzopyran-6-one (1) were obtained from the endolichenic fungus Myxotrichum sp. by using OMSAC (One Strain, Many Compounds) method. The planar structures of these new compounds were determined by NMR experiment and HRESIMS data, and the absolute configuration of 1 was established by X-ray diffraction, and the stereochemistry of the new compounds 2-4 were determined by same biosynthesis origin, and similar CD spectra with 1. Allelopathic test showed that compound 4 significantly retarded root elongation of Arabidopsis thaliana seed, indicating that this fungus might contribute to the defense of its host lichen. From the view of biosynthetic pathway, all four compounds 1-4 might be originated from Non-Reduced Polyketide synthase (NR-PKS).
authors.affiliation: Institute of Medicinal Plant Development Yunnan Branch, Chinese Academy of Medical Sciences and Peking Union Medical College, Jinghong, P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yuan
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Guo
authors.affiliation: College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Jinan, P.R. China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Ma
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Institute of Medicinal Plant Development Yunnan Branch, Chinese Academy of Medical Sciences and Peking Union Medical College, Jinghong, P.R. China.
authors.forename: Jun-Ling
authors.initials: JL
authors.lastname: Zhao
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Zhong-Mei
authors.initials: ZM
authors.lastname: Zou
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Ding
mesh_terms: D064089:Allelopathy; D001203:Ascomycota / Q000378:metabolism*; D018360:Crystallography, X-Ray; D008011:Lichens / Q000382:microbiology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000187:drug effects / Q000254:growth & development; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D061065:Polyketides
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