title: Probable involvement of p11 with interferon alpha induced depression.
abstract: Depression is one of the major side effects of interferon alpha (IFN-α) treatment, but the molecular mechanism underlying IFN-α-induced depression remains unclear. Several studies have shown that the serotonin receptors 5-HTR1b and 5-HTR4 play key roles in the anti-depression effects associated with p11 (S100A10). We investigated the effects of IFN-α on the regulation of p11, 5-HTR1b and 5-HTR4 in mice and human neuroblastoma cells (SH-sy5y). We found that intraperitoneal injection with IFN-α in Balb/c mice resulted in an increased immobility in FST and TST, and potently lowered the protein levels of p11, 5-HTR1b and 5-HTR4 in the hippocampus or cingulate gyrus. IFN-α significantly down-regulated the protein levels of p11, 5-HTR1b and 5-HTR4 in SH-sy5y cells, in a time- and dose-dependent manner. Our study revealed that over-expression of p11 could prevent the IFN-α-induced down-regulation of 5-HTR1b and 5-HTR4. The results indicated that IFN-α treatment resulted in p11 down-regulation, which subsequently decreased 5-HTR1b and 5-HTR4 in vitro or in vivo. Our findings suggested that p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-α-induced depression.
authors.affiliation: Research Center for Immunology, School of Basic Medical Sciences, Xinxiang Medical University, China.|Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Jiqiang
authors.initials: J
authors.lastname: Guo
authors.affiliation: Research Center for Immunology, School of Basic Medical Sciences, Xinxiang Medical University, China.|Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Research Center for Immunology, School of Basic Medical Sciences, Xinxiang Medical University, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Huaxia
authors.initials: H
authors.lastname: Ding
authors.affiliation: Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Song
authors.affiliation: Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Namei
authors.initials: N
authors.lastname: Xia
authors.affiliation: Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Mingfang
authors.initials: M
authors.lastname: Li
authors.affiliation: Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Yinming
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Xianzhang
authors.initials: X
authors.lastname: Hu
authors.affiliation: Laboratory of Molecular Biology, National Institute of Mental Health, USA.
authors.forename: Haojiang
authors.initials: H
authors.lastname: Luan
authors.affiliation: Research Center for Immunology, School of Basic Medical Sciences, Xinxiang Medical University, China.|Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine in Henan Province, School of Laboratory Medicine, Xinxiang Medical University, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D017306:Annexin A2 / Q000235:genetics / Q000378:metabolism*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D003863:Depression / Q000139:chemically induced* / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation / Q000187:drug effects; D006179:Gyrus Cinguli / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D007103:Immobilization; D007150:Immunohistochemistry; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D044302:Receptor, Serotonin, 5-HT1B; D011994:Recombinant Proteins / Q000009:adverse effects; D009418:S100 Proteins / Q000235:genetics / Q000378:metabolism*; D013550:Swimming; D013623:Tail; D013997:Time Factors; D000099248:S100 Calcium Binding Protein A10
chemical_list: D017306:Annexin A2; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D012333:RNA, Messenger; D044302:Receptor, Serotonin, 5-HT1B; D011994:Recombinant Proteins; D009418:S100 Proteins; D000099248:S100 Calcium Binding Protein A10
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