title: Skeletal Muscle Pathology in X-Linked Myotubular   Myopathy: Review With Cross-Species Comparisons.
abstract: X-linked myotubular myopathy (XLMTM) is a devastating, rare, congenital myopathy caused by mutations in the MTM1 gene, resulting in a lack of or dysfunction of the enzyme myotubularin. This leads to severe perinatal weakness and distinctive muscle pathology. It was originally thought that XLMTM was related to developmental arrest in myotube maturation; however, the generation and characterization of several animal models have significantly improved our understanding of clinical and pathological aspects of this disorder. Myotubularin is now known to participate in numerous cellular processes including endosomal trafficking, excitation-contraction coupling, cytoskeletal organization, neuromuscular junction structure, autophagy, and satellite cell proliferation and survival. The available vertebrate models of XLMTM, which vary in severity from complete absence to reduced functional levels of myotubularin, recapitulate features of the human disease to a variable extent. Understanding how pathological endpoints in animals with XLMTM translate to human patients will be essential to interpret preclinical treatment trials and translate therapies into human clinical studies. This review summarizes the published animal models of XLMTM, including those of zebrafish, mice, and dogs, with a focus on their pathological features as compared to those seen in human XLMTM patients.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Lawlor
authors.forename: Alan H
authors.initials: AH
authors.lastname: Beggs
authors.forename: Ana
authors.initials: A
authors.lastname: Buj-Bello
authors.forename: Martin K
authors.initials: MK
authors.lastname: Childers
authors.forename: James J
authors.initials: JJ
authors.lastname: Dowling
authors.forename: Emma S
authors.initials: ES
authors.lastname: James
authors.forename: Hui
authors.initials: H
authors.lastname: Meng
authors.forename: Steven A
authors.initials: SA
authors.lastname: Moore
authors.forename: Suyash
authors.initials: S
authors.lastname: Prasad
authors.forename: Benedikt
authors.initials: B
authors.lastname: Schoser
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Sewry
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D018482:Muscle, Skeletal / Q000473:pathology*; D020914:Myopathies, Structural, Congenital / Q000473:pathology*; D013045:Species Specificity
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