title: ATR-FTIR and Raman spectroscopic investigation of the electroporation-mediated transdermal delivery of a nanocarrier system containing an antitumour drug.
abstract: The aim of the present work was the optimization of the transdermal delivery of a lyotropic liquid crystal genistein-based formulation (LLC-GEN). LLC was chosen as medium in view of the poor solubility of GEN in water. Membrane diffusion and penetration studies were carried out with a Franz diffusion cell, through a synthetic membrane in vitro, a chick chorioallantoic membrane ex ovo, and ex vivo excised human epidermis. Thereafter, LLC-GEN was combined with electroporation (EP) to enhance the transdermal drug delivery. The synergistic effect of EP was verified by in vivo ATR-FTIR and ex vivo Raman spectroscopy on hairless mouse skin.
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Szeged, H-6720, Hungary; Gedeon Richter Plc., Budapest, H-1103, Hungary.
authors.forename: Boglárka
authors.initials: B
authors.lastname: Balázs
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Szeged, H-6720, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Sipos
authors.affiliation: Department of Pharmacognosy, "Victor Babes" University of Medicine and Pharmacy, Timisoara, 300041, Romania.
authors.forename: Corina
authors.initials: C
authors.lastname: Danciu
authors.affiliation: Discipline of Pharmacology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, 300041, Romania.
authors.forename: Stefana
authors.initials: S
authors.lastname: Avram
authors.affiliation: Discipline of Pharmaceutical Chemistry, "Victor Babes" University of Medicine and Pharmacy, Timisoara, 300041, Romania.
authors.forename: Codruta
authors.initials: C
authors.lastname: Soica
authors.affiliation: Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, 300041, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Dehelean
authors.affiliation: Dr. Derm Clinic of Anti-Aging Dermatology, Aesthetic Laser and Plastic Surgery, Budapest, H-1026, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Varju
authors.affiliation: Department of Dermatology and Allergology, University of Szeged, Szeged, H-6720, Hungary; Department of Oral Biology and Experimental Dental Research, University of Szeged, Szeged, H-6720, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Erős
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Szeged, H-6720, Hungary.
authors.forename: Mária
authors.initials: M
authors.lastname: Budai-Szűcs
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Szeged, H-6720, Hungary.
authors.forename: Szilvia
authors.initials: S
authors.lastname: Berkó
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Szeged, H-6720, Hungary.
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Csányi
keywords: (120.7280) Vibration analysis; (170.3880) Medical and biological imaging; (170.5660) Raman spectroscopy; (300.6300) Spectroscopy, Fourier transforms; (300.6340) Spectroscopy, infrared; (300.6540) Spectroscopy, ultraviolet
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