title: Exosome-mediated communication in the ovarian follicle.
abstract: Cells are able to produce and release different types of vesicles, such as microvesicles and exosomes, in the extracellular microenvironment. According to the scientific community, both microvesicles and exosomes are able to take on and transfer different macromolecules from and to other cells, and in this way, they can influence the recipient cell function. Among the different macromolecule cargos, the most studied are microRNAs. MicroRNAs are a large family of non-coding RNAs involved in the regulation of gene expression. They control every cellular process and their altered regulation is involved in human diseases. Their presence in mammalian follicular fluid has been recently demonstrated, and here, they are enclosed within microvesicles and exosomes or they can also be associated to protein complexes. The presence of microvesicles and exosomes carrying microRNAs in follicular fluid could represent an alternative mechanism of autocrine and paracrine communication inside the ovarian follicle. The outcomes from these studies could be important in basic reproductive research but could also be useful for clinical application. In fact, the characterization of extracellular vesicles in follicular fluid could improve reproductive disease diagnosis and provide biomarkers of oocyte quality in ART (Assisted Reproductive Treatment).
authors.affiliation: Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics G. Sichel, University of Catania, Via S. Sofia 87, 95024, Catania, Italy. dipietro@unict.it.
authors.forename: C
authors.initials: C
authors.lastname: Di Pietro
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D055354:Exosomes / Q000502:physiology*; D000067128:Extracellular Vesicles / Q000378:metabolism; D005260:Female; D015571:Follicular Fluid / Q000166:cytology / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D006080:Ovarian Follicle / Q000166:cytology* / Q000502:physiology; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs
keywords: Exosomes; Extracellular vesicles; MicroRNAs; Ovarian follicle
references.citation: Domest Anim Endocrinol. 2013 Oct;45(3):122-5
references.pmid: 23932580
references.citation: Hum Reprod Update. 2007 May-Jun;13(3):289-312
references.pmid: 17242016
references.citation: Hum Reprod Update. 2015 Sep-Oct;21(5):627-39
references.pmid: 26071427
references.citation: J Assist Reprod Genet. 2014 Mar;31(3):355-62
references.pmid: 24390626
references.citation: Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1433-42
references.pmid: 25713383
references.citation: J Biol Chem. 1987 Jul 5;262(19):9412-20
references.pmid: 3597417
references.citation: Reprod Sci. 2015 Dec;22(12):1474-83
references.pmid: 25736328
references.citation: Genes (Basel). 2014 Aug 25;5(3):684-708
references.pmid: 25158044
references.citation: Tumour Biol. 2015 Mar;36(3):2007-12
references.pmid: 25391424
references.citation: Nat Cell Biol. 2007 Jun;9(6):654-9
references.pmid: 17486113
references.citation: J Extracell Vesicles. 2015 May 14;4:27066
references.pmid: 25979354
references.citation: Dev Cell. 2011 Oct 18;21(4):708-21
references.pmid: 21962903
references.citation: Hum Reprod. 2010 Oct;25(10):2569-78
references.pmid: 20719813
references.citation: J Neurosci. 2010 May 19;30(20):6838-51
references.pmid: 20484626
references.citation: Trends Endocrinol Metab. 2010 Feb;21(2):96-103
references.pmid: 19913438
references.citation: Differentiation. 2011 Jan;81(1):11-24
references.pmid: 20864249
references.citation: Science. 2008 Feb 29;319(5867):1244-7
references.pmid: 18309083
references.citation: J Clin Endocrinol Metab. 2013 Jul;98(7):3068-79
references.pmid: 23666971
references.citation: J Exp Med. 1996 Mar 1;183(3):1161-72
references.pmid: 8642258
references.citation: Nature. 2008 May 22;453(7194):539-43
references.pmid: 18404146
references.citation: J Biol Chem. 2014 Jun 27;289(26):18239-57
references.pmid: 24828505
references.citation: Nat Rev Genet. 2009 Oct;10(10):704-14
references.pmid: 19763153
references.citation: J Cell Biol. 2010 Sep 20;190(6):1079-91
references.pmid: 20837771
references.citation: Hum Mol Genet. 2012 Oct 15;21(R1):R125-34
references.pmid: 22872698
references.citation: Reproduction. 2013 Sep;146(3):273-82
references.pmid: 23813447
references.citation: Reprod Fertil Dev. 2015 Jul;27(6):897-905
references.pmid: 25945781
references.citation: Reprod Biol Endocrinol. 2009;7:40
references.pmid: 19413899
references.citation: Recent Prog Horm Res. 2002;57:195-220
references.pmid: 12017544
references.citation: Hum Reprod Update. 2011 Jul-Aug;17(4):525-40
references.pmid: 21444328
references.citation: Reprod Biomed Online. 2007 Jun;14(6):758-64
references.pmid: 17579993
references.citation: Cell Cycle. 2009 Sep 1;8(17):2741-7
references.pmid: 19717979
references.citation: Reprod Biol Endocrinol. 2014;12:44
references.pmid: 24884710
references.citation: Fertil Steril. 2015 Oct;104(4):1037-1046.e1
references.pmid: 26209829
references.citation: Cancer Res. 2006 May 1;66(9):4795-801
references.pmid: 16651434
references.citation: Cell. 2004 Jan 23;116(2):281-97
references.pmid: 14744438
references.citation: Natl Sci Rev. 2014 Jun 1;1(2):190-204
references.pmid: 25821635
references.citation: Mol Cell Endocrinol. 2012 Jun 5;356(1-2):24-30
references.pmid: 21684319
references.citation: Int J Mol Sci. 2013 Mar 06;14(3):5338-66
references.pmid: 23466882
references.citation: Genes (Basel). 2013 Mar 28;4(2):152-70
references.pmid: 24705158
references.citation: Hum Reprod Update. 2014 Jan-Feb;20(1):1-11
references.pmid: 24082041
references.citation: Genomics Proteomics Bioinformatics. 2015 Feb;13(1):17-24
references.pmid: 25724326
references.citation: Front Genet. 2013 Sep 05;4:173
references.pmid: 24046777
references.citation: Clin Chem. 2010 Nov;56(11):1733-41
references.pmid: 20847327
references.citation: Cell Cycle. 2015;14(3):289-90
references.pmid: 25616496
references.citation: Cold Spring Harb Perspect Med. 2015;5(9):a022962
references.pmid: 25986593
references.citation: Mol Reprod Dev. 2014 Apr;81(4):284-314
references.pmid: 24273059
references.citation: Biol Reprod. 2010 Jun;82(6):1021-9
references.pmid: 20164441
references.citation: Biol Reprod. 2015 Nov;93(5):117
references.pmid: 26423123
references.citation: Curr Opin Cell Biol. 2015 Aug;35:69-77
references.pmid: 26001269
references.citation: Sci Rep. 2015;5:8689
references.pmid: 25732513
references.citation: PLoS One. 2013;8(11):e78505
references.pmid: 24223816
references.citation: J Ovarian Res. 2015;8:51
references.pmid: 26232057
references.citation: Fertil Steril. 2014 Dec;102(6):1751-61.e1
references.pmid: 25241362
references.citation: J Immunol. 2003 Nov 1;171(9):4830-6
references.pmid: 14568962
references.citation: Fertil Steril. 1991 Aug;56(2):265-72
references.pmid: 2070856
references.citation: Exp Cell Res. 2010 Jul 15;316(12):1977-84
references.pmid: 20399774
references.citation: Nat Rev Clin Oncol. 2011 Aug;8(8):467-77
references.pmid: 21647195
references.citation: Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3589-90
references.pmid: 25762069
references.citation: Nat Cell Biol. 2012 Oct;14(10):1036-45
references.pmid: 22983114
references.citation: Biol Reprod. 2012 Mar;86(3):71
references.pmid: 22116803
references.citation: Hum Fertil (Camb). 2014 Jun;17(2):90-8
references.pmid: 24684237