title: Effectiveness of allergic rhinitis treatments in real-life with a focus on MP-AzeFlu.
abstract: For any allergic rhinitis (AR) treatment, it is crucial to provide evidence not only of efficacy (assessed in randomized controlled trials (RCTs)) but also of effectiveness in real-life. Observational studies provide valuable data on the use and results associated with interventions prescribed in real-life. However, real-life evidence supporting available AR treatment options is sparse with effectiveness only established for oral antihistamines (desloratadine, ebastine), intranasal corticosteroids (mometasone furoate, fluticasone propionate (FP)), allergen immunotherapy and omalizumab. A novel intranasal formulation of azelastine hydrochloride and FP in a single spray (MP-AzeFlu) shows great promise, with the effectiveness observed in real-life exceeding that noted in RCTs. This review summarises real-life data on MP-AzeFlu, which provides rapid and sustained symptom control irrespective of patient age, AR phenotype or disease severity. We call for high quality real-life research in addition to RCTs to inform future AR treatment guidelines.
authors.affiliation: a Center for Rhinology and Allergology , Wiesbaden , Germany.
authors.forename: Ludger
authors.initials: L
authors.lastname: Klimek
authors.affiliation: b Département de Pneumologie et Addictologie , University Hospital of Montpellier , Montpellier , France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Demoly
authors.affiliation: c Division of Applied Health Sciences , University of Aberdeen , Aberdeen , UK.
authors.forename: David
authors.initials: D
authors.lastname: Price
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000068298:Fluticasone / Q000008:administration & dosage / Q000627:therapeutic use*; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D010793:Phthalazines / Q000008:administration & dosage / Q000627:therapeutic use*; D065631:Rhinitis, Allergic / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D006633:Histamine Antagonists; D010793:Phthalazines; D000068298:Fluticasone; C020976:azelastine
keywords: Allergic rhinitis; MP-AzeFlu; effectiveness; real-life