title: Keloids: Animal models and pathologic equivalents to study tissue fibrosis.
abstract: Animal models are crucial for the study of fibrosis. Keloids represent a unique type of fibrotic scarring that occurs only in humans, thus presenting a challenge for those studying the pathogenesis of this disease and its therapeutic options. Here, several animal models of fibrosis currently in use are described, emphasizing recent progress and highlighting encouraging challenges.
authors.affiliation: Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Jaana
authors.initials: J
authors.lastname: Marttala
authors.affiliation: Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Andrews
authors.affiliation: Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA; The Joan and Joel Rosenbloom Research Center for Fibrotic Diseases, Thomas Jefferson University, Philadelphia, PA 19107, USA; Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Rosenbloom
authors.affiliation: Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA; Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: jouni.uitto@jefferson.edu.
authors.forename: Jouni
authors.initials: J
authors.lastname: Uitto
mesh_terms: D000818:Animals; D017439:Cicatrix, Hypertrophic / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000473:pathology; D005355:Fibrosis / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007627:Keloid / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D051379:Mice; D017346:Protein Serine-Threonine Kinases / Q000235:genetics
chemical_list: C475219:Tsk1 protein, mouse; D017346:Protein Serine-Threonine Kinases
keywords: Animal models; Hypertrophic scar; Keloids; Tissue fibrosis
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