title: Effect of intraoperative constant rate infusion of lidocaine on short-term survival of dogs with septic peritonitis: 75 cases (2007-2011).
abstract: OBJECTIVE
  To investigate whether intraoperative administration of a lidocaine infusion to dogs with septic peritonitis was associated with short-term (48 hours) survival after surgery.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  75 dogs with septic peritonitis.
  
  
  METHODS
  Medical records of dogs with septic peritonitis that underwent laparotomy between January 2007 and December 2011 at the Royal Veterinary College were reviewed. Select variables during the preoperative, intraoperative, and postoperative periods and short-term survival after surgery were compared between dogs that received an opioid only (group O; n = 33) and dogs that received lidocaine (50 μg/kg/min [22.7 μg/kg/min], IV; group L; 42) in addition to an opioid during surgery.
  
  
  RESULTS
  The proportion of dogs that survived for 48 hours after surgery was significantly greater for group L (35/42) than for group O (20/33). Intraoperative infusion of lidocaine increased the odds of short-term survival (OR, 8.77; 95% CI, 1.94 to 39.57). No significant differences were observed between the 2 treatment groups for variables assessed during the preoperative and postoperative periods. During the intraoperative period, more dogs in group L received an IV bolus of a synthetic colloid than did dogs in group O, but the number of IV boluses administered was not associated with short-term survival.
  
  
  CONCLUSIONS
  Results indicated that IV infusion of lidocaine might improve the short-term survival of dogs with septic peritonitis. Prospective clinical trials are necessary to determine the efficacy of lidocaine as a supportive treatment for dogs with septic peritonitis.
authors.forename: Luca
authors.initials: L
authors.lastname: Bellini
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Seymour
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D004285:Dogs; D005260:Female; D007262:Infusions, Intravenous / Q000662:veterinary; D007430:Intraoperative Care / Q000662:veterinary; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D010538:Peritonitis / Q000188:drug therapy / Q000401:mortality / Q000601:surgery / Q000662:veterinary*; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D008012:Lidocaine