title: sHLA-G1 and HLA-G5 levels are decreased in Tunisian women with multiple abortion.
abstract: Pregnancy is associated with increased levels of soluble (s) human leukocyte antigen (HLA)-G molecules, while during abortion these molecules are decreased. To date, little is known about the role of sHLA-G isoforms during abortion. In this study, we investigated the levels of total sHLA-G and its isoforms: HLA-G1 (membrane shedded isoform) and alternative spliced HLA-G5 in plasma samples obtained from 55 women who had experienced spontaneous abortion, 108 pregnant healthy women and 56 non pregnant healthy women. We found that pregnant women exhibited higher amounts of sHLA-G compared to either non pregnant women or women with abortion. Among women who had experienced spontaneous abortion, women with recurrent abortions (RSA) had lower sHLA-G than women with only one abortion. In particular, RSA women were characterized by the absence of sHLA-G1 isoform, suggesting a possible implication in abortion event.
authors.affiliation: Laboratory Microorganismes et Biomolécules Actives, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia. Electronic address: ines.zidi@techemail.com.
authors.forename: Inès
authors.initials: I
authors.lastname: Zidi
authors.affiliation: Department of Medical Sciences, Section Microbiology, University of Ferrara, Ferrara, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Rizzo
authors.affiliation: Ecole supérieure des Sciences et Techniques de la Santé de Sousse, Tunisia.
authors.forename: Aicha
authors.initials: A
authors.lastname: Bouaziz
authors.affiliation: Laboratory Microorganismes et Biomolécules Actives, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia; Laboratory of Microbiology-Immunology, CHU Farhat Hached, Sousse, Tunisia.
authors.forename: Ahmed Baligh
authors.initials: AB
authors.lastname: Laaribi
authors.affiliation: Faculty of Medicine Ibn Al Jazzar, Sousse, Tunisia.
authors.forename: Nour
authors.initials: N
authors.lastname: Zidi
authors.affiliation: Department of Medical Sciences, Section Microbiology, University of Ferrara, Ferrara, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Di Luca
authors.affiliation: Groupement de Santé de base, Sousse, Tunisia.
authors.forename: Henda
authors.initials: H
authors.lastname: Tlili
authors.affiliation: Department of Medical Sciences, Section Microbiology, University of Ferrara, Ferrara, Italy.
authors.forename: Daria
authors.initials: D
authors.lastname: Bortolotti
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000235:genetics* / Q000276:immunology; D000328:Adult; D000483:Alleles; D015415:Biomarkers; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D059951:HLA-G Antigens / Q000097:blood / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics; D014416:Tunisia; D055815:Young Adult
chemical_list: D015415:Biomarkers; D059951:HLA-G Antigens; D012333:RNA, Messenger
keywords: Abortion; HLA-G5; Pregnancy; sHLA-G; sHLA-G1