title: Poly(2-aminobenzothiazole)-coated graphene oxide/magnetite nanoparticles composite as an efficient sorbent for determination of non-steroidal anti-inflammatory drugs in urine sample.
abstract: In this study, for the first time, 2-aminobenzothiazole monomer was polymerized on Fe3O4 NPs, graphene oxide/Fe3O4 (GO/Fe3O4) and graphene/Fe3O4 (G/Fe3O4) nanocomposites. The synthesized magnetic nanosorbents were characterized by various techniques. The extraction ability of these nanosorbents including Fe3O4, GO/Fe3O4, G/Fe3O4, Fe3O4@poly(2-aminobenzothiazole) (Fe3O4@PABT), GO/Fe3O4@PABT and G/Fe3O4@PABT were compared for dispersive-micro-solid phase extraction of three non-steroidal anti-inflammatory drugs. The results revealed that GO/Fe3O4@PABT nanocomposite demonstrates higher extraction efficiency for naproxen, diclofenac and ibuprofen as selected model analytes. Following the sorption and elution steps, the model analytes were quantified by high performance liquid chromatography-photo diode array detection. Afterwards, a central composite design methodology combined with desirability function approach was applied to find out the optimal experimental conditions. Under the optimized conditions, the limits of detection and linear dynamic ranges were achieved in the range of 0.07-0.3 μg L(-1) and 0.25-2000 μg L(-1), respectively. The percent of extraction recovery was 87.4, 85.5 and 90.5% for naproxen, diclofenac and ibuprofen, respectively. The obtained relative standard deviation (n=5) was 7.2, 5.4 and 6.4% for naproxen, diclofenac and ibuprofen, respectively. Ultimately, this method was employed for urinary monitoring of the target analytes and satisfactory results were obtained.
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Asgharinezhad
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G.C., Evin, Tehran, Iran. Electronic address: h-ebrahim@sbu.ac.ir.
authors.forename: Homeira
authors.initials: H
authors.lastname: Ebrahimzadeh
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D006108:Graphite / Q000737:chemistry; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D052616:Solid Phase Extraction; D016482:Urinalysis / Q000379:methods*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D058185:Magnetite Nanoparticles; D010087:Oxides; D006108:Graphite
keywords: Central composite design and desirability function; Dispersive micro-solid phase extraction; Graphene oxide/Fe(3)O(4)@poly(2-aminobenzothiazole); High performance liquid chromatography; Non-steroidal anti-inflammatory drugs; Urinary monitoring