title: Interstitial Lung Disease in Systemic Scleroderma, Complicated with Bilateral Pulmonary Aspergilloma: An Unusual Association.
abstract: Aspergilloma or mycetoma is a saprophytic fungal infection that colonizes pre-existing excavated lung lesion. However, its association with systemic sclerosis related interstitial lung disease is unusual and scarcely found in literature. We report a middle aged female with long standing systemic sclerosis, who was on immunosuppressive therapy for many years, presented with repeated haemoptysis. Although provisionally pulmonary tuberculosis was suspected, imaging investigations showed presence of bilateral masses inside bullous air spaces along with air-crescent sign suggestive of fungal ball. Subsequent Computed tomography guided needle aspiration from lung mass confirmed Aspergillus fumigatus as aetiologic agent on fungal culture. Patient was treated conservatively for haemoptysis and with oral antifungal drug as surgical removal of fungal ball was not an option due to poor pulmonary reserve. Although she had been treated with itraconazole for more than three years, she had recurrent haemoptysis during this period without any significant regression of size of the aspergilloma. Management of aspergilloma in a background of extensive interstitial lung disease remains poorly defined and complicated. Thereby, overall prognosis is unfavourable and depends on evolution of both underlying scleroderma as well as aspergilloma.
authors.affiliation: Assistant Professor, Department of Pulmonary Medicine, Nilratan Sircar Medical College & Hospital , Kolkata, West Bengal, India .
authors.forename: Saumen
authors.initials: S
authors.lastname: Nandi
authors.affiliation: Residential Medical Officer (RMO) Cum Clinical Tutor, Department of Pulmonary Medicine, Nilratan Sircar Medical College & Hospital , Kolkata, West Bengal, India .
authors.forename: Avradip
authors.initials: A
authors.lastname: Santra
authors.affiliation: Assistant Professor, Department of Dermatology & Venereology, Nilratan Sircar Medical College & Hospital , Kolkata, West Bengal, India .
authors.forename: Loknath
authors.initials: L
authors.lastname: Ghoshal
authors.affiliation: Demonstrator, Department of Pathology, Midnapore Medical College & Hospital , Paschim Medinipur, West Bengal, India .
authors.forename: Soumya
authors.initials: S
authors.lastname: Kundu
keywords: Breathlessness; Recurrent haemoptysis; Systemic sclerosis
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