title: The association of resting state heart rate variability and 24-hour blood pressure variability in spinal cord injury.
abstract: Patients with high cervical complete spinal cord injuries (tetraplegia) sustain damage to the autonomic neural pathways that influence cardiovascular functioning and produce variability in the heart rate (HR) and blood pressure (BP). In non-injured individuals, an inverse relationship exists between resting autonomic control of the heart (as evidenced by HR variability (HRV)) and BP variability (BPV). This study examined the relationship between HRV, BP and BPV in individuals with tetraplegic (n=10) and paraplegic (n=10) spinal cord injuries, and a group of healthy controls (n=14). Resting HRV at baseline and 24-hour ambulatory BP measurements were collected from electrocardiogram measures of each participant. HRV was quantified using time- and frequency-domain measures. The standard deviation of the BP measurements was used as an index of BPV. Multivariate analyses of variance were performed to examine group differences for laboratory-based and 24-h dependent variables. The MANOVAs for HRV parameters (λ(14,50)=.352, p=.010, η(2)=.407) and for BP indices and HR (λ(16,48)=.318, p=.013, η(2)=.436) were significant. Furthermore, in line with existing evidence, we found that vagally mediated HRV was inversely related to BPV in healthy controls. However, this relationship did not hold for the tetraplegia group (ρ<|.42|), and mixed results were found for the paraplegia group (e.g., ρ<|.29| for time domain HRV, ρ>|.65| for low-frequency power). These results support the conclusion that the damage to the spinal sympathetic pathways to the heart found in people with tetraplegia causes a significant disruption in baroreflex control of BP.
authors.affiliation: Department of Psychology, The Ohio State University, Columbus, OH, USA. Electronic address: Thayer.39@osu.edu.
authors.forename: Julian F
authors.initials: JF
authors.lastname: Thayer
authors.affiliation: Department of Psychological Medicine, The University of Auckland, Auckland, New Zealand.
authors.forename: John J
authors.initials: JJ
authors.lastname: Sollers
authors.affiliation: Department of Clinical Psychology and Psychotherapy, University of Hamburg, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Clamor
authors.affiliation: Department of Psychology, The Ohio State University, Columbus, OH, USA; Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Koenig
authors.affiliation: Department of Health Psychology, University of Missouri, Columbia, USA.
authors.forename: Kristofer J
authors.initials: KJ
authors.lastname: Hagglund
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D013119:Spinal Cord Injuries / Q000503:physiopathology*; D055815:Young Adult
keywords: Baroreflex; Blood pressure; Heart rate variability; Spinal cord injury