title: External signals shape the epigenome.
abstract: A new study shows how a single cytokine, interleukin-4, regulates hematopoietic lineage choice by activating the JAK3-STAT6 pathway, which causes dendritic-cell-specific DNA demethylation.
authors.affiliation: Department of Biosciences and Nutrition, Karolinska Institute, 141 57, Huddinge, Sweden. andreas.lennartsson@ki.se.
authors.forename: Andreas
authors.initials: A
authors.lastname: Lennartsson
mesh_terms: D019070:Cell Lineage / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology / Q000378:metabolism; D049308:Dioxygenases; D057890:Epigenomics; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics* / Q000378:metabolism; D053616:Janus Kinase 3 / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D050800:STAT6 Transcription Factor / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D004268:DNA-Binding Proteins; C508598:IL4 protein, human; D011518:Proto-Oncogene Proteins; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; D015847:Interleukin-4; D049308:Dioxygenases; C541081:TET2 protein, human; C507933:JAK3 protein, human; D053616:Janus Kinase 3
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