title: Multiple Roles of Peroxiredoxins in Inflammation.
abstract: Inflammation is a pathophysiological response to infection or tissue damage during which high levels of reactive oxygen and nitrogen species are produced by phagocytes to kill microorganisms. Reactive oxygen and nitrogen species serve also in the complex regulation of inflammatory processes. Recently, it has been proposed that peroxiredoxins may play key roles in innate immunity and inflammation. Indeed, peroxiredoxins are evolutionarily conserved peroxidases able to reduce, with high rate constants, hydrogen peroxide, alkyl hydroperoxides and peroxynitrite which are generated during inflammation. In this minireview, we point out different possible roles of peroxiredoxins during inflammatory processes such as cytoprotective enzymes against oxidative stress, modulators of redox signaling, and extracellular pathogen- or damage-associated molecular patterns. A better understanding of peroxiredoxin functions in inflammation could lead to the discovery of new therapeutic targets.
authors.affiliation: Group of Animal Molecular and Cellular Biology, Institut des Sciences de la Vie (ISV), Université catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Bernard
authors.initials: B
authors.lastname: Knoops
authors.affiliation: Group of Animal Molecular and Cellular Biology, Institut des Sciences de la Vie (ISV), Université catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Argyropoulou
authors.affiliation: Group of Animal Molecular and Cellular Biology, Institut des Sciences de la Vie (ISV), Université catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Sarah
authors.initials: S
authors.lastname: Becker
authors.affiliation: Group of Animal Molecular and Cellular Biology, Institut des Sciences de la Vie (ISV), Université catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Laura
authors.initials: L
authors.lastname: Ferté
authors.affiliation: Group of Animal Molecular and Cellular Biology, Institut des Sciences de la Vie (ISV), Université catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Oksana
authors.initials: O
authors.lastname: Kuznetsova
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D018384:Oxidative Stress; D010545:Peroxides / Q000378:metabolism; D054464:Peroxiredoxins / Q000378:metabolism*; D030421:Peroxynitrous Acid / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D010545:Peroxides; D030421:Peroxynitrous Acid; D054464:Peroxiredoxins
keywords: inflammation; innate immunity; peroxiredoxins; reactive nitrogen species; reactive oxygen species; redox signaling
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