title: Ocular transient receptor potential channel function in health and disease.
abstract: Transient receptor potential (TRP) channels sense and transduce environmental stimuli into Ca(2+) transients that in turn induce responses essential for cell function and adaptation. These non-selective channels with variable Ca(2+) selectivity are grouped into seven different subfamilies containing 28 subtypes based on differences in amino acid sequence homology. Many of these subtypes are expressed in the eye on both neuronal and non-neuronal cells where they affect a host of stress-induced regulatory responses essential for normal vision maintenance. This article reviews our current knowledge about the expression, function and regulation of TRPs in different eye tissues. We also describe how under certain conditions TRP activation can induce responses that are maladaptive to ocular function. Furthermore, the possibility of an association between TRP mutations and disease is considered. These findings contribute to evidence suggesting that drug targeting TRP channels may be of therapeutic benefit in a clinical setting. We point out issues that must be more extensively addressed before it will be possible to decide with certainty that this is a realistic endeavor. Another possible upshot of future studies is that disease process progression can be better evaluated by profiling changes in tissue specific functional TRP subtype activity as well as their gene and protein expression.
authors.affiliation: Department of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xuejuan Road, Wenzhou, Zhejiang, 325027, P. R. China. preinach@yahoo.com.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Reinach
authors.affiliation: Department of Ophthalmology, Charité-University Medicine Berlin, Campus Virchow-Clinic, Augustenburger Platz 1, 13353, Berlin, Germany. stefan.mergler@charite.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Mergler
authors.affiliation: Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan. yokada@wakayama-med.ac.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Okada
authors.affiliation: Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan. shizuya@wakayama-med.ac.jp.
authors.forename: Shizuya
authors.initials: S
authors.lastname: Saika
mesh_terms: D000818:Animals; D005128:Eye Diseases / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009799:Ocular Physiological Phenomena; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000502:physiology*
chemical_list: D050051:Transient Receptor Potential Channels
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