title: Nickel-Catalyzed Decarboxylative Difluoroalkylation of α,β-Unsaturated Carboxylic Acids.
abstract: The first example of nickel-catalyzed decarboxylative fluoroalkylation of α,β-unsaturated carboxylic acids has been developed with commonly available fluoroalkyl halides. This novel transformation has demonstrated broad substrate scope, excellent functional-group tolerance, mild reaction conditions, and excellent stereoselectivity. Mechanistic investigations indicate that a fluoroalkyl radical is involved in the catalytic cycle.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Fei
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Su
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Lan
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. xswang77@ustc.edu.cn.|Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Shanghai, 200032, China. xswang77@ustc.edu.cn.
authors.forename: Xi-Sheng
authors.initials: XS
authors.lastname: Wang
keywords: fluoroalkylation; nickel; olefins; radicals; synthetic methods