title: Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice.
abstract: Amyloid-β (Aβ) plays a critical role as a biomarker in Alzheimer's disease (AD) diagnosis. In addition to its diagnostic potential in the brain, recent studies have suggested that changes of Aβ level in the plasma can possibly indicate AD onset. In this study, we found that plasma Aβ(1-42) concentration increases with age, while the concentration of Aβ(1-42) in the cerebrospinal fluid (CSF) decreases in APPswe, PS1M146V and TauP301L transgenic (3xTg-AD) mice, if measurements were made before formation of ThS-positive plaques in the brain. Our data suggests that there is an inverse correlations between the plasma and CSF Aβ(1-42) levels until plaques form in transgenic mice's brains and that the plasma Aβ concentration possesses the diagnostic potential as a biomarker for diagnosis of early AD stages.
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Soo Min
authors.initials: SM
authors.lastname: Cho
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Sejin
authors.initials: S
authors.lastname: Lee
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.
authors.forename: Seung-Hoon
authors.initials: SH
authors.lastname: Yang
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea.|GoshenBiotech, 83-2 Wolmun-ri, Wabu-eup, Namyangju-si, Gyeonggi-do, Republic of Korea.
authors.forename: Hye Yun
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Department of Medical Education, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA, USA.
authors.forename: Michael Jisoo
authors.initials: MJ
authors.lastname: Lee
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Hyunjin Vincent
authors.initials: HV
authors.lastname: Kim
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Jiyoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
authors.forename: Seungyeop
authors.initials: S
authors.lastname: Baek
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Jin
authors.initials: J
authors.lastname: Yun
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
authors.forename: Dohee
authors.initials: D
authors.lastname: Kim
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Center for Neuroscience and Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.
authors.forename: Yakdol
authors.initials: Y
authors.lastname: Cho
authors.affiliation: Center for Neuroscience and Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.
authors.forename: Jiwan
authors.initials: J
authors.lastname: Woo
authors.affiliation: Center for BioMicroSystems, Brain Science Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.
authors.forename: Tae Song
authors.initials: TS
authors.lastname: Kim
authors.affiliation: Center for Neuro-Medicine, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: YoungSoo
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000375:Aging / Q000097:blood / Q000134:cerebrospinal fluid*; D000544:Alzheimer Disease / Q000097:blood* / Q000134:cerebrospinal fluid*; D016229:Amyloid beta-Peptides / Q000097:blood* / Q000134:cerebrospinal fluid*; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008822:Mice, Transgenic; D010446:Peptide Fragments / Q000097:blood* / Q000134:cerebrospinal fluid*; D010766:Phosphorylation; D058225:Plaque, Amyloid / Q000097:blood* / Q000134:cerebrospinal fluid*; D021381:Protein Transport
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)
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