title: What About Tachycardia-induced Cardiomyopathy?
abstract: Long-standing tachycardia is a well-recognised cause of heart failure and left ventricular dysfunction, and has led to the nomenclature, tachycardia-induced cardiomyopathy (TIC). TIC is generally a reversible cardiomyopathy if the causative tachycardia can be treated effectively, either with medications, surgery or catheter ablation. The diagnosis is usually made after demonstrating recovery of left ventricular function with normalisation of heart rate in the absence of other identifiable aetiologies. One hundred years after the first reported case of TIC, our understanding of the pathophysiology of TIC in humans remains limited despite extensive work in animal models of TIC. In this review we will discuss the proposed mechanisms of TIC, the causative tachyarrhythmias and their treatment, outcomes for patients diagnosed with TIC, and future directions for research and clinical care.
authors.affiliation: Clinical Fellow, Harvard Medical School, Beth Israel Deaconess Medical Center.
authors.forename: Ethan R
authors.initials: ER
authors.lastname: Ellis
authors.affiliation: Herman C. Dana Professor of Medicine, Harvard Medical School, Chief of the Cardiovascular Division, Beth Israel Deaconess Medical Center and Director, Harvard-Thorndike Electrophysiology Institute and Arrhythmia Service, Beth Israel Deaconess Medical Center, Boston, US.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Josephson
keywords: Tachycardia-induced cardiomyopathy; atrial fibrillation; cardiomyopathy; premature ventricular contractions; supraventricular tachycardia; tachycardia-mediated cardiomyopathy; ventricular tachycardia
references.citation: Int J Mol Med. 1999 Feb;3(2):153-5
references.pmid: 9917522
references.citation: Pacing Clin Electrophysiol. 2012 Apr;35(4):465-70
references.pmid: 22303908
references.citation: Circ Arrhythm Electrophysiol. 2011 Aug;4(4):543-9
references.pmid: 21576277
references.citation: Eur J Cardiol. 1975 Apr;2(4):459-66
references.pmid: 1126354
references.citation: J Lab Clin Med. 1988 Oct;112(4):426-32
references.pmid: 3171352
references.citation: Circulation. 1968 Dec;38(6):1074-84
references.pmid: 5725769
references.citation: Clin Sci (Lond). 1982 May;62(5):465-9
references.pmid: 7075144
references.citation: Cardiovasc Res. 1991 Jun;25(6):468-74
references.pmid: 1889061
references.citation: Europace. 2008 Mar;10(3):358-63
references.pmid: 18308756
references.citation: Am J Cardiol. 1993 Sep 1;72(7):560-6
references.pmid: 8362771
references.citation: Pacing Clin Electrophysiol. 1996 Sep;19(9):1391-2
references.pmid: 8880807
references.citation: Am J Physiol. 1991 Aug;261(2 Pt 2):H308-18
references.pmid: 1877659
references.citation: Circ Res. 1991 Oct;69(4):1058-67
references.pmid: 1934334
references.citation: J Cardiovasc Electrophysiol. 2011 Jun;22(6):663-8
references.pmid: 21235667
references.citation: J Thorac Cardiovasc Surg. 2002 Jul;124(1):43-9
references.pmid: 12091807
references.citation: J Cardiovasc Electrophysiol. 1997 Apr;8(4):445-50
references.pmid: 9106431
references.citation: Am J Physiol. 1991 Jun;260(6 Pt 2):H1903-11
references.pmid: 2058725
references.citation: Pacing Clin Electrophysiol. 1993 Jun;16(6):1275-84
references.pmid: 7686657
references.citation: Circ Arrhythm Electrophysiol. 2009 Apr;2(2):135-45
references.pmid: 19808458
references.citation: J Interv Card Electrophysiol. 1998 Mar;2(1):71-6
references.pmid: 9869999
references.citation: Heart. 1998 Jun;79(6):588-92
references.pmid: 10078086
references.citation: Int Heart J. 2008 Jan;49(1):39-47
references.pmid: 18360063
references.citation: Am J Physiol. 1993 Sep;265(3 Pt 2):H801-9
references.pmid: 8214113
references.citation: Cardiovasc Res. 2001 Jan;49(1):127-34
references.pmid: 11121804
references.citation: Heart Rhythm. 2008 Sep;5(9):1320-2
references.pmid: 18774110
references.citation: J Am Coll Cardiol. 1989 Aug;14(2):489-95; discussion 496-8
references.pmid: 2754134
references.citation: Am J Cardiol. 1986 Mar 1;57(8):563-70
references.pmid: 3953440
references.citation: Pacing Clin Electrophysiol. 2001 Feb;24(2):166-71
references.pmid: 11270695
references.citation: Am J Cardiol. 1994 Aug 1;74(3):242-6
references.pmid: 8037128
references.citation: Heart Rhythm. 2012 Sep;9(9):1465-72
references.pmid: 22640894
references.citation: Arq Bras Cardiol. 1992 Apr;58(4):303-6
references.pmid: 1340700
references.citation: J Cardiovasc Electrophysiol. 2000 Mar;11(3):328-9
references.pmid: 10749356
references.citation: J Cardiovasc Electrophysiol. 2007 Jan;18(1):9-14
references.pmid: 17081210
references.citation: Circulation. 1991 Feb;83(2):635-44
references.pmid: 1991381
references.citation: Circulation. 1974 Aug;50(2):266-73
references.pmid: 4846635
references.citation: Pacing Clin Electrophysiol. 1998 Apr;21(4 Pt 1):760-3
references.pmid: 9584309
references.citation: Am J Cardiol. 1984 May 15;53(10):1465-6
references.pmid: 6720596
references.citation: Am Heart J. 1989 Nov;118(5 Pt 1):913-8
references.pmid: 2816702
references.citation: Heart Rhythm. 2008 Aug;5(8):1111-4
references.pmid: 18675220
references.citation: Basic Res Cardiol. 1992 Jan-Feb;87(1):65-79
references.pmid: 1567354
references.citation: Cardiovasc Res. 1992 Apr;26(4):362-6
references.pmid: 1638568
references.citation: Int J Cardiovasc Imaging. 2003 Aug;19(4):295-9
references.pmid: 14598897
references.citation: J Am Coll Cardiol. 1997 Aug;30(2):576-84
references.pmid: 9247535
references.citation: Am Heart J. 1993 Dec;126(6):1469-73
references.pmid: 8249807
references.citation: Pacing Clin Electrophysiol. 1983 Nov;6(6):1306-26
references.pmid: 6196741
references.citation: Cardiovasc Res. 2002 Apr;54(1):42-50
references.pmid: 12062360
references.citation: J Card Fail. 2002 Oct;8(5):326-32
references.pmid: 12411984
references.citation: J Am Coll Cardiol. 1985 Aug;6(2):405-9
references.pmid: 4019927
references.citation: J Card Fail. 1995 Jun;1(3):223-8
references.pmid: 9420655
references.citation: Circulation. 1987 Apr;75(4):857-67
references.pmid: 3829344
references.citation: Clin Cardiol. 2008 Apr;31(4):172-8
references.pmid: 18404727
references.citation: J Mol Cell Cardiol. 1992 Mar;24(3):277-94
references.pmid: 1320703
references.citation: Int J Mol Med. 2004 Mar;13(3):455-8
references.pmid: 14767579
references.citation: J Cardiovasc Electrophysiol. 2005 Jan;16(1):88-91
references.pmid: 15673396
references.citation: J Am Coll Cardiol. 1989 Jan;13(1):173-9
references.pmid: 2521228
references.citation: Pacing Clin Electrophysiol. 2013 May;36(5):612-7
references.pmid: 23379975
references.citation: Circulation. 1997 May 6;95(9):2327-8
references.pmid: 9142013
references.citation: Can J Physiol Pharmacol. 1988 Dec;66(12):1505-12
references.pmid: 3228785
references.citation: Circ Res. 1995 May;76(5):781-9
references.pmid: 7728995
references.citation: Pacing Clin Electrophysiol. 2005 Jul;28(7):710-21
references.pmid: 16008809
references.citation: Ann Noninvasive Electrocardiol. 2008 Jan;13(1):81-5
references.pmid: 18234010
references.citation: Heart Rhythm. 2012 Sep;9(9):1460-4
references.pmid: 22542704
references.citation: Pacing Clin Electrophysiol. 2002 Feb;25(2):191-4
references.pmid: 11915986
references.citation: Am Heart J. 1998 Sep;136(3):435-42
references.pmid: 9736134
references.citation: Am Heart J. 1971 Jun;81(6):790-8
references.pmid: 5088355
references.citation: Pacing Clin Electrophysiol. 1998 Nov;21(11 Pt 1):2073-8
references.pmid: 9826859
references.citation: J Am Coll Cardiol. 2001 Nov 15;38(6):1734-40
references.pmid: 11704389
references.citation: JAMA. 1985 Jan 18;253(3):391-2
references.pmid: 3965793
references.citation: J Card Fail. 2003 Apr;9(2):87-92
references.pmid: 12751128
references.citation: Am J Physiol. 1990 Jul;259(1 Pt 2):H218-29
references.pmid: 2375409
references.citation: Circulation. 2002 Jul 16;106(3):362-7
references.pmid: 12119254
references.citation: Int J Cardiol. 1996 Sep;56(1):75-81
references.pmid: 8891808
references.citation: Am J Cardiol. 1992 Jun 15;69(19):1570-3
references.pmid: 1598871
references.citation: Am J Med. 1949 Oct;7(4):478-89
references.pmid: 18140546
references.citation: Br Heart J. 1995 Sep;74(3):332-3
references.pmid: 7547032
references.citation: Pacing Clin Electrophysiol. 2011 Dec;34(12):1671-81
references.pmid: 21950798
references.citation: JAMA. 2002 Dec 25;288(24):3115-23
references.pmid: 12495391
references.citation: Pacing Clin Electrophysiol. 2013 May;36(5):e156-8
references.pmid: 21967685
references.citation: Heart Rhythm. 2011 Jul;8(7):1046-9
references.pmid: 21376837
references.citation: J Electrocardiol. 2010 Mar-Apr;43(2):146-54
references.pmid: 19879594
references.citation: Pacing Clin Electrophysiol. 1996 Jan;19(1):42-9
references.pmid: 8848376
references.citation: Eur J Pharmacol. 2003 Feb 14;461(2-3):149-58
references.pmid: 12586210
references.citation: Circulation. 1986 Nov;74(5):1075-84
references.pmid: 2945673
references.citation: Am J Cardiol. 1996 Dec 15;78(12 ):1431-3
references.pmid: 8970421
references.citation: Can J Physiol Pharmacol. 1990 Jan;68(1):34-9
references.pmid: 2328442
references.citation: J Cardiol. 2009 Aug;54(1):134-8
references.pmid: 19632533
references.citation: Am J Cardiol. 1992 Feb 15;69(5):489-92
references.pmid: 1736612
references.citation: Am J Physiol. 1995 Feb;268(2 Pt 2):H836-47
references.pmid: 7864211
references.citation: Am J Med. 2002 Oct 1;113(5):359-64
references.pmid: 12401529
references.citation: J Thorac Cardiovasc Surg. 1987 Jul;94(1):135-43
references.pmid: 3599999
references.citation: J Clin Invest. 1992 Mar;89(3):932-8
references.pmid: 1311723
references.citation: Circulation. 2000 Jun 6;101(22):2625-30
references.pmid: 10840015
references.citation: J Cardiovasc Pharmacol. 1992 May;19(5):691-700
references.pmid: 1381766
references.citation: Circulation. 2004 Jul 20;110(3):247-52
references.pmid: 15226218
references.citation: Pacing Clin Electrophysiol. 1997 Apr;20(4 Pt 1):953-9
references.pmid: 9127401
references.citation: J Am Coll Cardiol. 1990 Sep;16(3):739-44
references.pmid: 2387945
references.citation: J Am Coll Cardiol. 1997 Mar 15;29(4):709-15
references.pmid: 9091514
references.citation: Circ Res. 1991 Sep;69(3):590-600
references.pmid: 1873861
references.citation: Cardiovasc Res. 2003 Jul 1;59(1):67-77
references.pmid: 12829177
references.citation: Circ Res. 1991 Dec;69(6):1546-56
references.pmid: 1659503
references.citation: Heart. 2009 Aug;95(15):1230-7
references.pmid: 19429571
references.citation: Am Heart J. 1993 Apr;125(4):1047-53
references.pmid: 8465727
references.citation: Circ Res. 1991 Aug;69(2):332-43
references.pmid: 1650296
references.citation: Europace. 2005 Nov;7(6):604-10
references.pmid: 16216764
references.citation: Ultrasound Obstet Gynecol. 1997 Jul;10 (1):32-40
references.pmid: 9263421
references.citation: J Am Coll Cardiol. 2009 May 12;53(19):1791-7
references.pmid: 19422986
references.citation: Am Heart J. 1986 Sep;112(3):622-4
references.pmid: 3751876
references.citation: Am J Physiol. 1993 Oct;265(4 Pt 2):H1119-31
references.pmid: 8238398
references.citation: J Am Coll Cardiol. 1992 Dec;20(7):1650-60
references.pmid: 1452940
references.citation: Mayo Clin Proc. 2000 Aug;75(8):790-5
references.pmid: 10943231
references.citation: J Cardiovasc Electrophysiol. 2011 Jul;22(7):791-8
references.pmid: 21332870
references.citation: J Am Coll Cardiol. 1993 Sep;22(3):891-8
references.pmid: 8354829
references.citation: Heart Rhythm. 2013 Feb;10 (2):172-5
references.pmid: 23099051
references.citation: Am J Physiol. 1996 Dec;271(6 Pt 2):R1529-34
references.pmid: 8997349
references.citation: Br Heart J. 1988 May;59(5):572-7
references.pmid: 3382569
references.citation: Am J Med. 2003 Jan;114(1):51-5
references.pmid: 12543289
references.citation: Pacing Clin Electrophysiol. 1996 Apr;19(4 Pt 1):505-8
references.pmid: 8848402
references.citation: Eur Heart J. 2003 Jun;24(12):1143-52
references.pmid: 12804929
references.citation: Circulation. 1993 Jun;87(6):2016-22
references.pmid: 8504516
references.citation: Heart Rhythm. 2011 Oct;8(10):1608-14
references.pmid: 21699837
references.citation: Circulation. 1994 May;89(5):2241-50
references.pmid: 8181149
references.citation: Eur Heart J. 1992 Sep;13(9):1290-5
references.pmid: 1396842
references.citation: Arch Mal Coeur Vaiss. 1990 Jan;83(1):15-21
references.pmid: 2106301
references.citation: J Cardiovasc Electrophysiol. 2007 Jan;18(1):15-7
references.pmid: 17240546
references.citation: Circulation. 1995 Oct 15;92(8):2306-17
references.pmid: 7554216
references.citation: Heart Rhythm. 2007 Jul;4(7):863-7
references.pmid: 17599667
references.citation: Heart Rhythm. 2010 Jul;7(7):865-9
references.pmid: 20348027
references.citation: J Am Coll Cardiol. 1998 Jul;32(1):205-10
references.pmid: 9669271