title: Get the GIST? An overview of gastrointestinal stromal tumours.
abstract: GISTs are the most common mesenchymal neoplasms of the gastrointestinal tract. The last 20 years have been revolutionary in the understanding of these tumours and began with the discovery of c-KIT, a proto oncogene that when mutated forms the molecular basis for the growth and development of these malignancies. Surgery was previously considered to be the only treatment modality in both local and advanced disease, however, the introduction of immunotherapy agents such as tyrosine kinase inhibitors has had profound effects on how we now approach and manage these tumours. These novel agents have significantly reduced the frequency of disease recurrence and dramatically improved survival, and serve as a model for the study of targeted therapies in other solid tumors. We present a review of gastrointestinal stromal tumours and consider the current evidence based detection and management of these unique tumors.
authors.affiliation: Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland. geoff_watson7@hotmail.com.
authors.forename: G A
authors.initials: GA
authors.lastname: Watson
authors.affiliation: Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
authors.forename: D
authors.initials: D
authors.lastname: Kelly
authors.affiliation: Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Melland-Smith
authors.affiliation: Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
authors.forename: J
authors.initials: J
authors.lastname: Gleeson
authors.affiliation: Department of Surgery, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
authors.forename: G
authors.initials: G
authors.lastname: McEntee
authors.affiliation: Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
authors.forename: C M
authors.initials: CM
authors.lastname: Kelly
authors.affiliation: Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
authors.forename: J A
authors.initials: JA
authors.lastname: McCaffrey
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy*; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local; D000090063:Proto-Oncogene Mas; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D019009:Proto-Oncogene Proteins c-kit
keywords: Gastrointestinal stromal tumors (GIST); Imatinib mesylate; Review; c-KIT
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