title: Spectral domain optical coherence tomography in Celestone® retinal toxicity.
abstract: METHODS
  After inadvertent intravitreal injection of Celestone® (betamethasone sodium phosphate and acetate, benzalkonium chloride) in a patient, the macular spectral domain optical coherence tomography (SD-OCT) images showed hyper-reflectivity, thinning, and irregular spikes in the inner retinal layers. These early findings could explain the toxic secondary anatomical changes due to the drug itself and/or to its excipients. Late and permanent SD-OCT findings included changes in the ellipsoid zone and cystic-like spaces.
  
  
  CONCLUSIONS
  In this case, SD-OCT images can help to better understand the pathophysiology of the retinal damage and to diagnose the associated complications, providing information with prognostic value.
authors.affiliation: Servicio de Oftalmología, Hospital Universitario de La Princesa, Madrid, España. Electronic address: paulamarticorenaalvarez@hotmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Marticorena-Álvarez
authors.affiliation: Servicio de Oftalmología, Hospital Universitario de La Princesa, Madrid, España; Universidad Autónoma de Madrid, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: González Guijarro
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001623:Betamethasone / Q000009:adverse effects*; D006801:Humans; D058449:Intravitreal Injections; D012160:Retina; D012164:Retinal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D041623:Tomography, Optical Coherence
chemical_list: D000893:Anti-Inflammatory Agents; D001623:Betamethasone
keywords: Celestone®; Ellipsoid line; Intraocular injection; Inyección intraocular; Línea de los elipsoides; OCT-SD; Retinal toxicity; Toxicidad retiniana