title: Structural modeling of JAK1 mutations in T-cell acute lymphoblastic leukemia reveals a second contact site between pseudokinase and kinase domains.
authors.affiliation: Department of Pediatric Oncology/Hematology, Erasmus MC Rotterdam-Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Canté-Barrett
authors.affiliation: Netherlands Translational Research Center B.V., Oss, The Netherlands.
authors.forename: Joost C M
authors.initials: JC
authors.lastname: Uitdehaag
authors.affiliation: Department of Pediatric Oncology/Hematology, Erasmus MC Rotterdam-Sophia Children's Hospital, Rotterdam, The Netherlands j.meijerink@erasmusmc.nl.
authors.forename: Jules P P
authors.initials: JP
authors.lastname: Meijerink
mesh_terms: D006801:Humans; D053613:Janus Kinase 1 / Q000235:genetics*; D009154:Mutation; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
chemical_list: D053613:Janus Kinase 1
keywords: JAK1; T-cell acute lymphoblastic leukemia; TYK2; activating mutation; structure
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