title: Squamous Cell Carcinoma of the Oral Cavity and Oropharynx.
abstract: The most common malignancy to involve the oral cavity and oropharynx is squamous cell carcinoma (SCC). Because these oral cancers share an origin from the squamous epithelium, the pathology of oral SCC might be expected to be uniform and its diagnosis repetitive. In reality, the morphologic diversity in SCC, along with the propensity for reactive processes of the oral cavity to mimic SCC histologically, renders its diagnosis one of the more challenging in surgical pathology. This article discusses variants of oral and oropharyngeal SCC and highlights those features that help distinguish human papillomavirus-related from human papillomavirus-unrelated SCC.
authors.affiliation: Johns Hopkins Medical Institutions, 600 North Wolfe Street, Pathology 401, Baltimore, MD 21287, USA.
authors.forename: Justin A
authors.initials: JA
authors.lastname: Bishop
authors.affiliation: Milton J. Dance, Jr. Head and Neck Center, Greater Baltimore Medical Center, 6569 North Charles Street, Suite 401, Baltimore, MD 21204, USA.
authors.forename: James J
authors.initials: JJ
authors.lastname: Sciubba
authors.affiliation: Johns Hopkins Medical Institutions, 401 North Broadway, Weinberg 2242, Baltimore, MD 21231, USA.
authors.forename: William H
authors.initials: WH
authors.lastname: Westra