title: HYPERGLYCAEMIC HEMIBALLISMUS: IMPLICATIONS FROM CONNECTIVITY ANALYSIS FOR COGNITIVE IMPAIRMENTS.
abstract: Hyperglycaemia induced movement disorders, such as hemiballism are rare disorders. The syndrome is characterised by the triad of hemiballism, contralateral T1-hyperintense striatal lesion and non-ketotic hyperglycaemia. Here we report a patient with untreated diabetes presenting with acute onset of hemiballism. MRI revealed T1 hyperintensity of the head of the caudate nucleus and the anterior putamen. The patient also had acantocytosis. Based on the detailed examination of the neuroradiological results and earlier findings we will discuss the pathomechanism. Based on previous findings microhemorrhages, extensive mineralisation, gemistocytic astrocytosis might play a role in the development of the imaging signs. The connectivity pattern of the striatal lesion showed extensive connections to the frontal cortex. In coexistence with that the most severe impairment was found on the phonemic verbal fluency task measuring frontal executive functions.
authors.forename: Zsigmond Tamás
authors.initials: ZT
authors.lastname: Kincses
authors.forename: Dávid
authors.initials: D
authors.lastname: Vadászi
authors.forename: Dezso
authors.initials: D
authors.lastname: Németh
authors.forename: Karolina
authors.initials: K
authors.lastname: Janacsek
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Szabó
authors.forename: Lívia
authors.initials: L
authors.lastname: Dézsi
authors.forename: Magor
authors.initials: M
authors.lastname: Babos
authors.forename: Erika
authors.initials: E
authors.lastname: Vörös
authors.forename: László
authors.initials: L
authors.lastname: Vécsei
mesh_terms: D000012:Abetalipoproteinemia / Q000209:etiology / Q000473:pathology; D000328:Adult; D002421:Caudate Nucleus / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology*; D003342:Corpus Striatum / Q000473:pathology*; D048909:Diabetes Complications / Q000473:pathology; D020820:Dyskinesias / Q000209:etiology* / Q000473:pathology; D056344:Executive Function; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term; D011699:Putamen / Q000473:pathology; D013064:Speech Disorders / Q000209:etiology* / Q000473:pathology