title: Cognitive-enhancing activities of the polyprenol preparation Ropren® in gonadectomized β-amyloid (25-35) rat model of Alzheimer's disease.
abstract: The present preclinical study was designed to examine the effects of prolonged Ropren® administration (8.6 mg/kg, orally, once daily, 28 days) in a β-amyloid (25-35) rat model of Alzheimer's disease following gonadectomy. The experimental model was created by intracerebroventricular injection of β-amyloid (25-35) into gonadectomized (GDX) rats and GDX rats with testosterone propionate (TP, 0.5mg/kg, subcutaneous, once daily, 28 days) supplementation. Ropren® was administered to the GDX rats and GDX rats treated with TP. Memory performance was assessed using the passive avoidance and the Morris water maze tests and the spontaneous locomotor activity was assessed using the open field test. Treatment with Ropren® significantly improved and restored the cognitive ability of GDX rats with β-amyloid (25-35)-induced amnesia in the passive avoidance test and Morris water maze. Co-administration of Ropren® with TP exerted a markedly synergistic memory-enhancing effect in the GDX rats with β-amyloid (25-35)-induced amnesia on the same models of memory testing. Ropren® administered alone or together with TP significantly enhanced crossing, frequency of rearing and grooming of the GDX rats with β-amyloid (25-35)-induced amnesia in the open field test. These results indicate that Ropren® has a marked memory-enhancing action in the experimental model of Alzheimer's disease in male rats with altered levels of androgens.
authors.affiliation: Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences, 6 Emb. Makarova, St. Petersburg 199034, Russia; Laboratory of Comparative Somnology and Neuroendocrinology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 44 Tores pr., St. Petersburg 194223, Russia; Department of Chemistry and Molecular Biology, ITMO University, 49 Kronversky pr., St. Petersburg 197101, Russia. Electronic address: julia.fedotova@mail.ru.
authors.forename: Julia
authors.initials: J
authors.lastname: Fedotova
authors.affiliation: Solagran Limited, Biotechnology Company, 98-106, Moray St, South Melbourne 3205, Australia.
authors.forename: Vagif
authors.initials: V
authors.lastname: Soultanov
authors.affiliation: Laboratory of Functional Biochemistry of Invertebrates, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, pr. Torez 44, St. Petersburg 194223, Russia.
authors.forename: Tamara
authors.initials: T
authors.lastname: Nikitina
authors.affiliation: Department of Wood Chemistry and Physical and Colloidal Chemistry, State Forest Technical University, 5 Institutsky per., St. Petersburg 194021, Russia.
authors.forename: Victor
authors.initials: V
authors.lastname: Roschin
authors.affiliation: Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences, 6 Emb. Makarova, St. Petersburg 199034, Russia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Ordyan
authors.affiliation: Department of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I, No. 11, 700506, Romania. Electronic address: hritcu@uaic.ro.
authors.forename: Lucian
authors.initials: L
authors.lastname: Hritcu
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000150:complications*; D016229:Amyloid beta-Peptides / Q000633:toxicity; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D018697:Nootropic Agents / Q000627:therapeutic use*; D009919:Orchiectomy; D010446:Peptide Fragments / Q000633:toxicity; D011126:Polypropylenes / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000097:blood
chemical_list: D016229:Amyloid beta-Peptides; D018697:Nootropic Agents; D010446:Peptide Fragments; D011126:Polypropylenes; C074636:amyloid beta-protein (25-35); D013739:Testosterone
keywords: Alzheimer's disease; Gonadectomy; Memory; Ropren®; Testosterone; β-Amyloid (25–35)