title: An Overview of Genome-Wide Association Studies in Alzheimer's Disease.
abstract: Genome-wide association studies (GWASs) have revealed a plethora of putative susceptibility genes for Alzheimer's disease (AD). With the sole exception of the APOE gene, these AD susceptibility genes have not been unequivocally validated in independent studies. No single novel functional risk genetic variant has been identified. In this review, we evaluate recent GWASs of AD, and discuss their significance, limitations, and challenges in the investigation of the genetic spectrum of AD.
authors.affiliation: Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, 100053, China.
authors.forename: Luxi
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, 100053, China. jjp@ccmu.edu.cn.|Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China. jjp@ccmu.edu.cn.|Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, 100053, China. jjp@ccmu.edu.cn.|Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, 100053, China. jjp@ccmu.edu.cn.
authors.forename: Jianping
authors.initials: J
authors.lastname: Jia
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4
keywords: Alzheimer’s disease susceptibility genes; Apolipoprotein E; Association analysis; Common variant
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