title: Distribution of cytokine gene polymorphisms in six Orang Asli subgroups in Peninsular Malaysia.
abstract: Cytokines are involved in immune responses and the pathogenesis of various diseases. Allelic variations within the genes coding for various ∼30 kDa cytokine protein/glycoproteins have been reported for many populations and have been the subjects of many ancestry and health analyses. In this study, we typed 22 single nucleotide polymorphisms (SNPs) in 13 cytokine genes of 165 Orang Asli individuals by using sequence specific primer-polymerase chain reaction (SSP-PCR) assay. The volunteers came from all across the Peninsular of Malaysia and belong to six Orang Asli subgroups; Batek, Kensiu, Lanoh, Che Wong, Semai and Orang Kanaq. Here we report our general findings and original genotype data and their associated analyses (Hardy-Weinberg proportions, estimation of allele and haplotype frequencies) can be found in the supplementary files and will be held at Allele Frequency Net Database (AFND).
authors.affiliation: Biomedicine Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia.
authors.forename: Hanim K
authors.initials: HK
authors.lastname: Norhalifah
authors.affiliation: Biomedicine Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia.
authors.forename: Wan U Wan
authors.initials: WU
authors.lastname: Syafawati
authors.affiliation: Biomedicine Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia.
authors.forename: Nor F
authors.initials: NF
authors.lastname: Che Mat
authors.affiliation: School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Chambers
authors.affiliation: Human Identification Unit, Forensic Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia. Electronic address: edinur@usm.my.
authors.forename: Hisham A
authors.initials: HA
authors.lastname: Edinur
mesh_terms: D000483:Alleles; D016207:Cytokines / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008296:Malaysia; D020641:Polymorphism, Single Nucleotide
chemical_list: D016207:Cytokines
keywords: Cytokine; Orang Asli; Peninsular Malaysia; Proto-Malays; Semang; Senoi