title: Phagocytes Get Close to Their Enemies.
abstract: Phagocytosis is key for many organismal functions. In a recent issue of Cell, Freeman et al. (2016) demonstrate a feed-forward signaling mechanism wherein F-actin and integrin receptors drive contact formation between phagocytes and antibody-coated solid particles, signaling their engulfment. This mechanism translates nanoscale proximity effects into wider self-propagating signals.
authors.affiliation: The Kennedy Institute of Rheumatology, The University of Oxford, Oxford OX3 7FY, UK. Electronic address: michael.dustin@kennedy.ox.ac.uk.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Dustin
authors.affiliation: Radcliffe Department of Medicine and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, The University of Oxford, Oxford OX3 9DS, UK. Electronic address: simon.davis@imm.ox.ac.uk.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Davis
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D000818:Animals; D006801:Humans; D016023:Integrins / Q000378:metabolism; D010586:Phagocytes / Q000166:cytology*; D010587:Phagocytosis / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D000199:Actins; D016023:Integrins