title: Protective effects of berberine on high fat-induced kidney damage by increasing serum adiponectin and promoting insulin sensitivity.
abstract: Berberine (BBR) has been reported in several studies in cell and animal models. However, the mechanism of actions is not fully understood. The present study was therefore aimed to explore the effects of berberine on insulin sensitivity and kidney damage in a high fat diet rat model. Impaired glucose tolerance rats induced by injection of berberine while fed with high fat laboratory chow. After rats were treated for 4 weeks, OGTT and IPITT were determined. Mass and PAS were used to study the kidney tissue. ELISA was used to detect the protein concentration of CRP and TNF-α. Western blot was used to detect the proteins adiponectin, adipoR1, adipoR2 and p-AMPK expression level. These encouraging findings suggest that berberine has excellent pharmacological potential to prevent kidney damage.
authors.affiliation: Department of Endocrinology, Shanghai Fifth People's Hospital Affiliated to Fudan University Shanghai, China.
authors.forename: Ueyue
authors.initials: U
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, Shanghai Fifth People's Hospital Affiliated to Fudan University Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cha
authors.affiliation: Department of Endocrinology, Shanghai Fifth People's Hospital Affiliated to Fudan University Shanghai, China.
authors.forename: Xinmei
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Endocrinology, Shanghai Fifth People's Hospital Affiliated to Fudan University Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Shanghai Fifth People's Hospital Affiliated to Fudan University Shanghai, China.
authors.forename: Zaoping
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Shanghai Fifth People's Hospital Affiliated to Fudan University Shanghai, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Shanghai Fifth People's Hospital Affiliated to Fudan University Shanghai, China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Shanghai Fifth People's Hospital Affiliated to Fudan University Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sheng
authors.affiliation: Department of Endocrinology, Shanghai Fifth People's Hospital Affiliated to Fudan University Shanghai, China.
authors.forename: Heyuan
authors.initials: H
authors.lastname: Ding
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D052242:Adiponectin / Q000097:blood*; D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D019610:Cytoprotection; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000097:blood / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D017208:Rats, Wistar; D054419:Receptors, Adiponectin / Q000378:metabolism; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D015854:Up-Regulation
chemical_list: D052242:Adiponectin; C499920:Adipoq protein, rat; D001786:Blood Glucose; D007328:Insulin; D054419:Receptors, Adiponectin; D014409:Tumor Necrosis Factor-alpha; C504339:adiponectin receptor 1, rat; C506573:adiponectin receptor 2, rat; D001599:Berberine; D002097:C-Reactive Protein; D055372:AMP-Activated Protein Kinases
keywords: Berberine; adipoR1; adipoR2; adiponectin; p-AMPK
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