title: Fabrication, Characterization, and Biocompatibility of Polymer Cored Reduced Graphene Oxide Nanofibers.
abstract: Graphene nanofibers have shown a promising potential across a wide spectrum of areas, including biology, energy, and the environment. However, fabrication of graphene nanofibers remains a challenging issue due to the broad size distribution and extremely poor solubility of graphene. Herein, we report a facile yet efficient approach for fabricating a novel class of polymer core-reduced graphene oxide shell nanofiber mat (RGO-CSNFM) by direct heat-driven self-assembly of graphene oxide sheets onto the surface of electrospun polymeric nanofibers without any requirement of surface treatment. Thus-prepared RGO-CSNFM demonstrated excellent mechanical, electrical, and biocompatible properties. RGO-CSNFM also promoted a higher cell anchorage and proliferation of human bone marrow mesenchymal stem cells (hMSCs) compared to the free-standing RGO film without the nanoscale fibrous structure. Further, cell viability of hMSCs was comparable to that on the tissue culture plates (TCPs) with a distinctive healthy morphology, indicating that the nanoscale fibrous architecture plays a critically constructive role in supporting cellular activities. In addition, the RGO-CSNFM exhibited excellent electrical conductivity, making them an ideal candidate for conductive cell culture, biosensing, and tissue engineering applications. These findings could provide a new benchmark for preparing well-defined graphene-based nanomaterial configurations and interfaces for biomedical applications.
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University , Zhoukou 466001, P. R. China.|School of Mechanical & Aerospace Engineering, Nanyang Technological University , 50 Nanyang Avenue, 639798, Singapore.
authors.forename: Lin
authors.initials: L
authors.lastname: Jin
authors.affiliation: Materials Science Institute, PCFM Lab and DSAPM Lab, School of Chemistry and Chemical Engineering, Sun Yat-sen University , Guangzhou 510275, P. R. China.
authors.forename: Dingcai
authors.initials: D
authors.lastname: Wu
authors.affiliation: School of Mechanical & Aerospace Engineering, Nanyang Technological University , 50 Nanyang Avenue, 639798, Singapore.
authors.forename: Shreyas
authors.initials: S
authors.lastname: Kuddannaya
authors.affiliation: School of Mechanical & Aerospace Engineering, Nanyang Technological University , 50 Nanyang Avenue, 639798, Singapore.
authors.forename: Yilei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University , Zhoukou 466001, P. R. China.
authors.forename: Zhenling
authors.initials: Z
authors.lastname: Wang
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006108:Graphite / Q000737:chemistry; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000187:drug effects*; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D010087:Oxides; D011108:Polymers; D006108:Graphite
keywords: electrospinning; graphene; hMSCs; nanofibers; tissue engineering