title: Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development.
abstract: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.
  
  
  CONCLUSIONS
  There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.
authors.affiliation: Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Ann
authors.initials: A
authors.lastname: Hellström
authors.affiliation: Department of Pediatrics, Institute of Clinical Sciences Lund, Skane University Hospital, Lund University, Lund, Sweden.
authors.forename: David
authors.initials: D
authors.lastname: Ley
authors.affiliation: Department of Pediatrics, Institute of Clinical Sciences Lund, Skane University Hospital, Lund University, Lund, Sweden.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Hansen-Pupp
authors.affiliation: Department of Neonatology, University Hospital, Karolinska Institute, Stockholm, Sweden.
authors.forename: Boubou
authors.initials: B
authors.lastname: Hallberg
authors.affiliation: Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Chatarina
authors.initials: C
authors.lastname: Löfqvist
authors.affiliation: Brigham and Women's Hospital, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: van Marter
authors.affiliation: Department of Neonatology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Mirjam
authors.initials: M
authors.lastname: van Weissenbruch
authors.affiliation: Genova Neonatal Intensive Care Unit, Instituto Pediatrico Giannina Gaslini, Genova, Italy.
authors.forename: Luca A
authors.initials: LA
authors.lastname: Ramenghi
authors.affiliation: University of Cambridge, Cambridge, UK.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Beardsall
authors.affiliation: Faculty of Academy of Medical Sciences, Department of Paediatrics, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
authors.forename: David
authors.initials: D
authors.lastname: Dunger
authors.affiliation: Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Anna-Lena
authors.initials: AL
authors.lastname: Hård
authors.affiliation: Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Lois E H
authors.initials: LE
authors.lastname: Smith
mesh_terms: D000818:Animals; D047109:Fetal Development; D020249:Hormone Replacement Therapy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood / Q000254:growth & development*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*
chemical_list: C583557:IGF1 protein, human; D007334:Insulin-Like Growth Factor I
keywords: Development; Foetus; Insulin-like growth factor 1; Metabolism; Preterm infant
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