title: Circulating TGF-β1 levels are negatively correlated with sclerostin levels in early postmenopausal women.
abstract: BACKGROUND
  TGF-β1 regulates bone metabolism and mediates bone turnover during postmenopause. Sclerostin negatively regulates Wnt signaling pathway and also has an important role in postmenopausal bone loss. Little is known about the relationship between serum TGF-β1 and sclerostin during menopause.
  
  
  METHODS
  We compared serum levels of TGF-β1 and sclerostin in pre- and postmenopausal women and assessed the potential correlations of these levels with each other and with serum levels of bone turnover markers and bone mineral density.
  
  
  RESULTS
  A total of 176 women (58 premenopausal, 62 early postmenopausal, and 56 late postmenopausal) were included in this study. Serum TGF-β1 level was significantly higher in early postmenopausal women compared with premenopausal (32.0±7.19 vs. 26.55±6.67 ng/ml, p=0.01) and late postmenopausal (32.0±7.19 vs. 28.65±7.70 pg/ml, p=0.031) women, and no significant differences in serum sclerostin levels were observed among the 3 groups. There was a significant negative correlation between TGF-β1 and sclerostin in early postmenopausal women, but not in other groups of women. Based on multiple regression analysis, only TGF-β1 (β=-0.362; p=0.007) was an independent predictor of sclerostin during early postmenopause.
  
  
  CONCLUSIONS
  Our findings suggest that serum TGF-β1 level increases during postmenopause and declines in old age. Sclerostin production is inhibited by TGF-β1 during early postmenopause.
authors.affiliation: Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, China; Research Center on Aging and Medicine, Fudan University, China. Electronic address: quncheng_2014@163.com.
authors.forename: Qun
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, China; Research Center on Aging and Medicine, Fudan University, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Tang
authors.affiliation: University of Rochester, School of Medicine, USA.
authors.forename: Tzong-Jen
authors.initials: TJ
authors.lastname: Sheu
authors.affiliation: Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, China; Research Center on Aging and Medicine, Fudan University, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Du
authors.affiliation: Research Center on Aging and Medicine, Fudan University, China; Central Laboratory, Huadong Hospital affiliated to Fudan University, China.
authors.forename: Jiemin
authors.initials: J
authors.lastname: Gan
authors.affiliation: Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, China; Research Center on Aging and Medicine, Fudan University, China.
authors.forename: Huilin
authors.initials: H
authors.lastname: Li
authors.affiliation: Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, China; Research Center on Aging and Medicine, Fudan University, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hong
authors.affiliation: Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, China; Research Center on Aging and Medicine, Fudan University, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, China; Research Center on Aging and Medicine, Fudan University, China.
authors.forename: Sihong
authors.initials: S
authors.lastname: Xue
authors.affiliation: Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, China; Research Center on Aging and Medicine, Fudan University, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins / Q000097:blood*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; C422903:SOST protein, human; D053773:Transforming Growth Factor beta1
keywords: Bone mass; Bone turnover; Menopause; Sclerostin; Transforming growth factor β 1; Women