title: Elevated STMN1 promotes tumor growth and invasion in endometrial carcinoma.
abstract: Overexpression of stathmin (STMN1) is closely linked to tumor metastases and poor prognosis in endometrial carcinoma (EC). However, the underlying mechanism is little known. In the present study, we investigated the expression of STMN1 in EC. Subsequently, we assessed the role of STMN1 in EC cell proliferation and migration. Our data show that STMN1 is upregulated in EC, and elevated expression of STMN1 is correlated positively with tumor stage and lymph node metastasis. In vitro, forced expression of STMN1 promoted cell invasion and migration. In contrast, knockdown of STMN1 inhibited cell aggressive behaviors. Moreover, the expression and the activity changes of matrix metalloproteinases (MMP)-2/9 were observed in EC cells after the cells being silenced or overexpression of STMN1. In conclusion, STMN1 is an oncogene and it enhances the growth and invasion of EC possibly by mediating the secretion and activation of MMP2 and MMP9 protein.
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated International Peace Maternity and Child Health Hospital, No. 910, Henshan Road, Xujiahui District, Shanghai, 200030, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, No. 1, Xueshi Road, Hangzhou, Zhejiang, 310006, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Department of Gynecology, Tongji University School of Medicine Affiliated Shanghai First Maternity and Infant Hospital, No. 2669 Gaoke West Road, Pudong New Area, Shanghai, 200126, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, No. 1, Xueshi Road, Hangzhou, Zhejiang, 310006, China.
authors.forename: Gufeng
authors.initials: G
authors.lastname: Xu
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People's Hospital, 650 New Songjiang Road, Shanghai, 201620, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Tong
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People's Hospital, 650 New Songjiang Road, Shanghai, 201620, China.
authors.forename: Jieqi
authors.initials: J
authors.lastname: Ke
authors.affiliation: Department of Gynecology, Tongji University School of Medicine Affiliated Shanghai First Maternity and Infant Hospital, No. 2669 Gaoke West Road, Pudong New Area, Shanghai, 200126, China. wanxiaoping@Tongji.edu.cn.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Wan
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002465:Cell Movement; D049109:Cell Proliferation; D016889:Endometrial Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D004717:Endometrium / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050777:Stathmin / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; C493995:STMN1 protein, human; D050777:Stathmin
keywords: Endometrial cancer; Gelatin zymography; MMP2; MMP9; STMN1
references.citation: J Cell Sci. 2002 Oct 15;115(Pt 20):3947-56
references.pmid: 12244132
references.citation: Oncogene. 2003 Dec 4;22(55):8924-30
references.pmid: 14654788
references.citation: Expert Rev Anticancer Ther. 2008 Sep;8(9):1461-70
references.pmid: 18759697
references.citation: Biosci Rep. 2014 Apr 1;34(2):
references.pmid: 27919028
references.citation: Oncotarget. 2015 Sep 8;6(26):22227-38
references.pmid: 26087399
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 24;106(12 ):4834-9
references.pmid: 19261849
references.citation: Clin Cancer Res. 2013 May 1;19(9):2331-41
references.pmid: 23538402
references.citation: Eur J Clin Invest. 1999 Sep;29(9):793-801
references.pmid: 10469168
references.citation: Int J Clin Exp Med. 2015 Apr 15;8(4):6502-9
references.pmid: 26131279
references.citation: Tumour Biol. 2015 Jan;36(1):399-408
references.pmid: 25266798
references.citation: PLoS One. 2014 Jun 11;9(6):e99907
references.pmid: 24918449
references.citation: Clin Cancer Res. 2011 May 15;17(10):3368-77
references.pmid: 21242118
references.citation: Folia Histochem Cytobiol. 2014;52(3):187-94
references.pmid: 25308734
references.citation: Cancer. 2002 Mar 1;94(5):1466-75
references.pmid: 11920503
references.citation: CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29
references.pmid: 25559415
references.citation: J Cell Biochem. 2004 Oct 1;93(2):242-50
references.pmid: 15368352
references.citation: Cochrane Database Syst Rev. 2014 May 15;(5):CD010681
references.pmid: 24832785
references.citation: J Cancer Res Clin Oncol. 2010 Oct;136(10):1545-56
references.pmid: 20155427
references.citation: Cancer Biol Ther. 2010 Sep 15;10(6):632-43
references.pmid: 20657188
references.citation: Lancet Oncol. 2012 Aug;13(8):e353-61
references.pmid: 22846840
references.citation: Mol Cancer Ther. 2006 Dec;5(12):3248-57
references.pmid: 17172428
references.citation: BMJ. 2011 Jul 06;343:d3954
references.pmid: 21734165