title: Semantic and emotional content of imagined representations in human occipitotemporal cortex.
abstract: Mental imagery is a critical cognitive function, clinically important, but poorly understood. When visual objects are perceived, many of their sensory, semantic and emotional properties are represented in occipitotemporal cortex. Visual imagery has been found to activate some of the same brain regions, but it was not known what properties are re-created in these regions during imagery. We therefore examined the representation during imagery for two stimuli in depth, by comparing the pattern of fMRI response to the patterns evoked by the perception of 200 diverse objects chosen to de-correlate their properties. Real-time, adaptive stimulus selection allowed efficient sampling of this broad stimulus space. Our experiments show that occipitotemporal cortex, which encoded sensory, semantic and emotional properties during perception, can robustly represent semantic and emotional properties during imagery, but that these representations depend on the object being imagined and on individual differences in style and reported vividness of imagery.
authors.affiliation: MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Mitchell
authors.affiliation: MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK.|Brain and Mind Institute, University of Western Ontario, London, Ontario N6A 5B7, Canada.
authors.forename: Rhodri
authors.initials: R
authors.lastname: Cusack
mesh_terms: D000293:Adolescent; D000328:Adult; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D007092:Imagination / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009778:Occipital Lobe / Q000502:physiology*; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation; D013702:Temporal Lobe / Q000502:physiology*; D055815:Young Adult
references.citation: Proc Natl Acad Sci U S A. 2011 May 17;108(20):8520-4
references.pmid: 21540329
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19569-74
references.pmid: 19887644
references.citation: J Vis. 2011;11(5):4
references.pmid: 21617025
references.citation: Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12125-30
references.pmid: 21730192
references.citation: Cereb Cortex. 2012 Feb;22(2):372-80
references.pmid: 21666128
references.citation: Curr Biol. 2000 Jan 13;10(1):16-22
references.pmid: 10660297
references.citation: Cortex. 2000 Jun;36(3):401-14
references.pmid: 10921667
references.citation: Neuron. 2000 Dec;28(3):979-90
references.pmid: 11163281
references.citation: J Cogn Neurosci. 2000 Nov;12(6):1013-23
references.pmid: 11177421
references.citation: Neuron. 2001 Jun;30(3):829-41
references.pmid: 11430815
references.citation: J Child Psychol Psychiatry. 2001 Sep;42(6):719-28
references.pmid: 11583244
references.citation: Mem Cognit. 2002 Dec;30(8):1179-88
references.pmid: 12661850
references.citation: Brain Res Cogn Brain Res. 2004 Jul;20(2):226-41
references.pmid: 15183394
references.citation: Br J Psychol. 1973 Feb;64(1):17-24
references.pmid: 4742442
references.citation: J Exp Psychol Gen. 1983 Jun;112(2):278-303
references.pmid: 6223974
references.citation: J Exp Psychol Hum Percept Perform. 1992 Feb;18(1):241-6
references.pmid: 1532190
references.citation: Nature. 1992 Oct 15;359(6396):636-7
references.pmid: 1406994
references.citation: Annu Rev Neurosci. 1995;18:193-222
references.pmid: 7605061
references.citation: J Psychiatry Neurosci. 2005 Jan;30(1):53-6
references.pmid: 15644999
references.citation: Schizophr Bull. 2005 Jan;31(1):97-104
references.pmid: 15888429
references.citation: Dev Psychopathol. 2005 Summer;17(3):851-63
references.pmid: 16262995
references.citation: Cortex. 1978 Mar;14(1):129-33
references.pmid: 16295118
references.citation: J Neurophysiol. 2005 Dec;94(6):4373-86
references.pmid: 16107528
references.citation: Neuron. 2005 Dec 8;48(5):859-72
references.pmid: 16337922
references.citation: J Cogn Neurosci. 2006 Feb;18(2):158-68
references.pmid: 16494678
references.citation: Science. 2006 Sep 8;313(5792):1402
references.pmid: 16959998
references.citation: Vision Res. 2007 Feb;47(4):474-8
references.pmid: 17239915
references.citation: Nature. 2008 Mar 20;452(7185):352-5
references.pmid: 18322462
references.citation: J Neurosci. 2011 May 18;31(20):7322-33
references.pmid: 21593316
references.citation: Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8135-9
references.pmid: 7667258
references.citation: Conscious Cogn. 1996 Sep;5(3):265-87
references.pmid: 8906404
references.citation: Brain. 1997 Jul;120 ( Pt 7):1163-71
references.pmid: 9236629
references.citation: Science. 2008 May 30;320(5880):1191-5
references.pmid: 18511683
references.citation: Curr Biol. 2008 Jul 8;18(13):982-6
references.pmid: 18583132
references.citation: Cereb Cortex. 2008 Aug;18(8):1788-98
references.pmid: 18042643
references.citation: Neuroimage. 2008 Aug 15;42(2):998-1031
references.pmid: 18579414
references.citation: Neuroimage. 2008 Oct 1;42(4):1714-27
references.pmid: 18674625
references.citation: Nat Neurosci. 2008 Nov;11(11):1352-60
references.pmid: 18836443
references.citation: Neuron. 2008 Dec 26;60(6):1126-41
references.pmid: 19109916
references.citation: Neuroimage. 2010 Apr 1;50(2):818-25
references.pmid: 20004247
references.citation: Clin Psychol Rev. 2010 Apr;30(3):349-62
references.pmid: 20116915
references.citation: Biol Cybern. 2010 Mar;102(3):227-60
references.pmid: 20148260
references.citation: Curr Biol. 2010 Mar 23;20(6):544-7
references.pmid: 20226665
references.citation: Neuroimage. 2011 Jan 15;54(2):1703-14
references.pmid: 20797441
references.citation: Cereb Cortex. 2011 Jan;21(1):35-47
references.pmid: 20375074
references.citation: Neuroimage. 2011 Feb 1;54(3):2418-25
references.pmid: 20974270
references.citation: Hum Brain Mapp. 2012 Feb;33(2):387-97
references.pmid: 21391273
references.citation: Neuroimage. 2012 Feb 15;59(4):4064-73
references.pmid: 22040738
references.citation: J Neurosci. 2012 Feb 22;32(8):2608-18
references.pmid: 22357845
references.citation: Neuron. 2012 Jun 21;74(6):1114-24
references.pmid: 22726840
references.citation: J Neurosci. 2013 Jun 19;33(25):10235-42
references.pmid: 23785139
references.citation: J Neurosci. 2014 Jan 1;34(1):163-70
references.pmid: 24381278
references.citation: Nat Neurosci. 2014 Aug;17(8):1114-22
references.pmid: 24952643
references.citation: Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14565-70
references.pmid: 25246586
references.citation: Neuropsychologia. 1998 Mar;36(3):239-49
references.pmid: 9622189
references.citation: J Neurosci. 2009 Feb 4;29(5):1565-72
references.pmid: 19193903
references.citation: Psychol Sci. 2009 Feb;20(2):207-14
references.pmid: 19170936
references.citation: Neuroimage. 2009 Mar 1;45(1):89-95
references.pmid: 19084072
references.citation: Nature. 2009 Apr 2;458(7238):632-5
references.pmid: 19225460
references.citation: Philos Trans R Soc Lond B Biol Sci. 2009 May 12;364(1521):1273-80
references.pmid: 19528008
references.citation: Cortex. 2008 Feb;44(2):109-18
references.pmid: 18387540