title: Biomimetic biphasic scaffolds for osteochondral defect repair.
abstract: The osteochondral defects caused by vigorous trauma or physical disease are difficult to be managed. Tissue engineering provides a possible option to regenerate the damaged osteochondral tissues. For osteochondral reconstruction, one intact scaffold should be considered to support the regeneration of both cartilage and subchondral bone. Therefore, the biphasic scaffolds with the mimic structures of osteochondral tissues have been developed to close this chasm. A variety of biomimetic bilayer scaffolds fabricated from natural or synthetic polymers, or the ones loading with growth factors, cells, or both of them make great progresses in osteochondral defect repair. In this review, the preparation and in vitro and/or in vivo verification of bioinspired biphasic scaffolds are summarized and discussed, as well as the prospect is predicted.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China;; Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, People's Republic of China.
authors.forename: Xuezhou
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China;
authors.forename: Jianxun
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, People's Republic of China.
authors.forename: Jincheng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China;
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhuang
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China;
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
keywords: biomaterial; biomimetic; biphasic scaffold; osteochondral regeneration; tissue engineering
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