title: Intrapericardial Amiodarone for the Prevention of Postoperative Atrial Fibrillation.
abstract: Despite probably being the most effective prophylactic drug for postoperative atrial fibrillation (POAF), amiodarone is reserved as a second-line agent because of its potential systemic side effects. Herein, we review the available experimental and clinical trials examining the effectiveness of intrapericardial (IPC) amiodarone administration in preventing POAF which, if confirmed by future studies, can have a significant impact on cardiac surgery practice.
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, Hamilton General Hospital, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Louay M
authors.initials: LM
authors.lastname: Habbab
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, Hamilton General Hospital, McMaster University, Hamilton, Ontario, Canada.
authors.forename: F Victor
authors.initials: FV
authors.lastname: Chu
mesh_terms: D000638:Amiodarone / Q000008:administration & dosage* / Q000009:adverse effects; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D006801:Humans; D036502:Infusions, Intralesional; D010496:Pericardium; D011183:Postoperative Complications / Q000517:prevention & control*
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone