title: Regional thermochemotherapy versus hepatic arterial infusion chemotherapy for palliative treatment of advanced hilar cholangiocarcinoma: a retrospective controlled study.
abstract: OBJECTIVE
  To retrospectively assess the efficacy of regional thermochemotherapy (TCT) compared with hepatic arterial infusion chemotherapy (HAIC)-alone for palliative treatment of advanced hilar cholangiocarcinoma (HC) and to determine the prognostic factors associated with survival.
  
  
  METHODS
  Forty-three consecutive patients with advanced HC underwent regional TCT (TCT group) and HAIC (HAIC group). We analyzed baseline characteristics, overall survival (OS), progression-free survival (PFS), stent patency time (SPT), adverse events (AEs), and prognostic factors for OS between the two groups.
  
  
  RESULTS
  OS of patients treated with regional TCT was significantly longer compared to that of patients treated with HAIC (median OS: 20.3 vs. 13.2 months, P = 0.004), and SPT and PFS were significantly increased in the TCT group compared with the HAIC group (median SPT: 26.5 vs. 10.5 months, P < 0.001; median PFS: 16.5 vs. 10.2 months, P = 0.001). TCT and metal stent insertion were two independent prognostic factors associated with survival. The treatment-related AEs were tolerable and similar in the two groups, except for hilar pain (34.6 %) and skin rashes (24.6 %) in the TCT group.
  
  
  CONCLUSIONS
  Our results show that regional TCT is safe and more effective than HAIC-alone and may be a promising option for palliative treatment of advanced HC. Metal stenting before TCT appears to improve patients' OS.
  
  
  CONCLUSIONS
  • Regional TCT is a novel combination for palliative treatment of advanced HC • Our data showed significantly promising outcomes in the TCT group • HC patients with metal stenting appeared to derive greater benefit from TCT.
authors.affiliation: Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, Guangdong, 510120, People's Republic of China.|Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
authors.forename: Yaoting
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Health Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
authors.forename: Huiqing
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, Guangdong, 510120, People's Republic of China.|Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
authors.forename: Xiongying
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, Guangdong, 510120, People's Republic of China.|Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, Guangdong, 510120, People's Republic of China.|Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
authors.forename: Jiayan
authors.initials: J
authors.lastname: Ni
authors.affiliation: Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, Guangdong, 510120, People's Republic of China.|Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, Guangdong, 510120, People's Republic of China.|Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Luo
authors.affiliation: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China. yaoherui@163.com.|Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China. yaoherui@163.com.
authors.forename: Herui
authors.initials: H
authors.lastname: Yao
authors.affiliation: Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, Guangdong, 510120, People's Republic of China. xulinfeng_sysh@163.com.|Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China. xulinfeng_sysh@163.com.
authors.forename: Linfeng
authors.initials: L
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001650:Bile Duct Neoplasms / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007261:Infusions, Intra-Arterial; D018285:Klatskin Tumor / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
keywords: Efficacy; Hilar cholangiocarcinoma; Prognostic factor; Thermochemotherapy; Treatment
references.citation: N Engl J Med. 2010 Apr 8;362(14):1273-81
references.pmid: 20375404
references.citation: Surg Oncol Clin N Am. 2014 Apr;23(2):247-63
references.pmid: 24560109
references.citation: Gut Liver. 2014 May;8(3):318-23
references.pmid: 24827630
references.citation: Radiology. 2004 Mar;230(3):792-802
references.pmid: 14739309
references.citation: Br J Surg. 2010 Jan;97(1):56-64
references.pmid: 19937985
references.citation: Gastrointest Endosc. 2002 Jul;56(1):33-9
references.pmid: 12085032
references.citation: Surg Today. 2006;36(1):19-24
references.pmid: 16378188
references.citation: World J Gastrointest Oncol. 2013 Jul 15;5(7):171-6
references.pmid: 23919111
references.citation: Cancer. 2003 Oct 15;98(8):1689-700
references.pmid: 14534886
references.citation: Surg Oncol Clin N Am. 2003 Jul;12(3):689-701
references.pmid: 14567025
references.citation: Radiology. 2005 Oct;237(1):361-5
references.pmid: 16118153
references.citation: Cancer J. 2009 May-Jun;15(3):216-24
references.pmid: 19556908
references.citation: Hepatology. 2011 Apr;53(4):1363-71
references.pmid: 21480336
references.citation: Radiology. 2014 Feb;270(2):400-8
references.pmid: 24471389
references.citation: Hepatogastroenterology. 2014 Jan-Feb;61(129):151-5
references.pmid: 24895812
references.citation: Dig Dis Sci. 2014 May;59(5):905-7
references.pmid: 24578246
references.citation: Anticancer Res. 2013 Jun;33(6):2747-53
references.pmid: 23749936
references.citation: Gastrointest Cancer Res. 2011 Sep;4(5-6):155-60
references.pmid: 22295126
references.citation: Int J Hyperthermia. 2013 May;29(3):194-205
references.pmid: 23557324
references.citation: Ann Surg Oncol. 2014 Aug;21(8):2675-83
references.pmid: 24664624
references.citation: Surg Endosc. 2016 Mar;30(3):1242-8
references.pmid: 26162420
references.citation: Clin Endosc. 2015 May;48(3):201-8
references.pmid: 26064819
references.citation: Ann Surg. 2013 Jul;258(1):129-40
references.pmid: 23059502
references.citation: N Engl J Med. 1999 Oct 28;341(18):1368-78
references.pmid: 10536130
references.citation: Expert Rev Gastroenterol Hepatol. 2012 Aug;6(4):481-95
references.pmid: 22928900
references.citation: HPB (Oxford). 2015 Aug;17(8):691-9
references.pmid: 26172136
references.citation: Eur Radiol. 2008 Mar;18(3):468-76
references.pmid: 17938935
references.citation: Eur J Cancer. 2009 Jan;45(2):228-47
references.pmid: 19097774
references.citation: Clin Anat. 1999;12(4):245-9
references.pmid: 10398383
references.citation: World J Hepatol. 2014 Aug 27;6(8):559-69
references.pmid: 25232449
references.citation: World J Gastrointest Oncol. 2010 Feb 15;2(2):68-75
references.pmid: 21160924
references.citation: Cancer. 2004 Jun 1;100(11):2422-9
references.pmid: 15160347
references.citation: Cancer. 2012 Oct 1;118(19):4737-47
references.pmid: 22415526
references.citation: Oncol Lett. 2013 Dec;6(6):1550-1558
references.pmid: 24260045
references.citation: Int J Hyperthermia. 2013 Dec;29(8):845-51
references.pmid: 24144336