title: Association between hip morphology and prevalence, clinical severity and progression of hip osteoarthritis over 3 years: The knee and hip osteoarthritis long-term assessment cohort results.
abstract: OBJECTIVE
  To assess the effects of variations in hip morphology on prevalence, clinical severity and progression of hip osteoarthritis.
  
  
  METHODS
  From 2007 to 2009, we conducted a study of 242 patients aged between 40 and 75 years with symptomatic lower limb osteoarthritis, as part of a population-based osteoarthritis cohort study in France. Standard radiographs of both hips were obtained at baseline and at three years. The progression of hip osteoarthritis was evaluated according to the radiological Kellgren-Lawrence score (KL) and clinical severity from the scores on a Visual Analogic Scale (VAS) for pain recorded yearly. Five measures were used to describe hip morphology: centre edge angle, acetabular index (AI), vertical centre anterior angle, acetabular depth and neck-shaft angle.
  
  
  RESULTS
  Of the 484 hips studied, 205 (42%) showed osteoarthritis at baseline and 16 (11 right and 5 left) underwent joint replacement during the follow-up. AI was the morphological measure most consistently and strongly associated with radiographic osteoarthritis at baseline (odds-ratio=1.05, 95% CI: 1.01-1.08 per degree of angle change), clinical severity (correlation coefficient with VAS during 3 years=0.15, P=0.004), radiological progression (odds-ratio=1.05, 95% CI: 1.00-1.10 per degree) and joint replacement (hazard ratio=1.18, 95% CI: 1.07-1.29 per degree).
  
  
  CONCLUSIONS
  Acetabular obliquity and especially AI is strongly, and likely causally, associated with the existence, severity and progression of hip osteoarthritis.
authors.affiliation: EA 4360 Apemac, University Paris-Descartes, University of Lorraine, 75013 Paris, France; Biostatistics and Epidemiology Unit, Hôtel-Dieu, Assistance publique-Hôpitaux de Paris, 1, place du Parvis-Notre-Dame, 75004 Paris, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bouyer
authors.affiliation: Rheumatology centre, Purpan University Hospital, 31000 Toulouse, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Mazieres
authors.affiliation: Faculty of medicine, School of public health, CHU de Brabois, 54500 Vandœuvre-lès-Nancy, France; CIC-EC CIE6, Inserm, 54500 Vandœuvre-lès-Nancy, France; Rheumatology department, CHU de Brabois, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Guillemin
authors.affiliation: Radiology department, Cavale-Blanche University Hospital, 29200 Brest, France.
authors.forename: Ronan
authors.initials: R
authors.lastname: Bouttier
authors.affiliation: Rheumatology department, groupe hospitalier Pitié-Salpêtrière, Assistance publique-Hôpitaux de Paris, 75013 Paris, France; GRC-08-EEMOIS, University Paris 6 Pierre-et-Marie-Curie, 75005 Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Fautrel
authors.affiliation: Medicine department, Laennec hospital, 29000 Quimper, France; Rheumatology department, Cavale-Blanche University Hospital, 29200 Brest, France.
authors.forename: Johanne
authors.initials: J
authors.lastname: Morvan
authors.affiliation: EA 4360 Apemac, University Paris-Descartes, University of Lorraine, 75013 Paris, France; Department of internal medicine, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 75015 Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Pouchot
authors.affiliation: Faculty of medicine, School of public health, CHU de Brabois, 54500 Vandœuvre-lès-Nancy, France; CIC-EC CIE6, Inserm, 54500 Vandœuvre-lès-Nancy, France; Rheumatology department, CHU de Brabois, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: Anne-Christine
authors.initials: AC
authors.lastname: Rat
authors.affiliation: Rheumatology department, Academic Hospital l'Archet 1, 06200 Nice, France.
authors.forename: Christian H
authors.initials: CH
authors.lastname: Roux
authors.affiliation: Rheumatology centre, Purpan University Hospital, 31000 Toulouse, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Verrouil
authors.affiliation: EA 2216, University Bretagne-Occidentale, 29200 Brest, France; Faculty of Medicine, Paul-Sabatier University, 31000 Toulouse, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Saraux
authors.affiliation: EA 4360 Apemac, University Paris-Descartes, University of Lorraine, 75013 Paris, France; Biostatistics and Epidemiology Unit, Hôtel-Dieu, Assistance publique-Hôpitaux de Paris, 1, place du Parvis-Notre-Dame, 75004 Paris, France. Electronic address: joel.coste@htd.aphp.fr.
authors.forename: Joël
authors.initials: J
authors.lastname: Coste
mesh_terms: D000077:Acetabulum / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001175:Arthrography / Q000379:methods; D019644:Arthroplasty, Replacement, Hip / Q000379:methods / Q000706:statistics & numerical data; D019645:Arthroplasty, Replacement, Knee / Q000379:methods / Q000706:statistics & numerical data; D015331:Cohort Studies; D016001:Confidence Intervals; D018450:Disease Progression; D005260:Female; D005602:France; D006621:Hip Joint / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D015995:Prevalence; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution
keywords: Cohort studies; Hip; Hip morphology; Osteoarthritis