title: Common swine models of cardiovascular disease for research and training.
abstract: Cardiovascular diseases are a major health concern and therefore an important topic in biomedical research. Large animal models allow researchers to assess the safety and efficacy of new cardiovascular procedures in systems that resemble human anatomy; additionally, they can be used to emulate scenarios for training purposes. Among the many biomedical models that are described in published literature, it is important that researchers understand and select those that are best suited to achieve the aims of their research, that facilitate the humane care and management of their research animals and that best promote the high ethical standards required of animal research. In this resource the authors describe some common swine models that can be easily incorporated into regular practices of research and training at biomedical institutions. These models use both native and altered vascular anatomy of swine to carry out research protocols, such as testing biological reactions to implanted materials, surgically creating aneurysms using autologous tissue and inducing myocardial infarction through closed-chest procedures. Such models can also be used for training, where native and altered vascular anatomy allow medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems.
authors.affiliation: Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Crisóstomo
authors.affiliation: Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.
authors.forename: Fei
authors.initials: F
authors.lastname: Sun
authors.affiliation: Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Maynar
authors.affiliation: Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.
authors.forename: Claudia
authors.initials: C
authors.lastname: Báez-Díaz
authors.affiliation: Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Blanco
authors.affiliation: Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.
authors.forename: Monica
authors.initials: M
authors.lastname: Garcia-Lindo
authors.affiliation: Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Usón-Gargallo
authors.affiliation: Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.
authors.forename: Francisco Miguel
authors.initials: FM
authors.lastname: Sánchez-Margallo
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000193:education; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D004195:Disease Models, Animal; D034421:Sus scrofa
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