title: Primary splenic angiosarcoma with fever and anemia: a case report and literature review.
abstract: Primary splenic angiosarcoma is an extremely rare and aggressive neoplasm. The prognosis of this disease is dismal, and the mean survival is less than 6 months after the diagnosis. This neoplasm typically presents with abdominal pain, splenomegaly, weight loss, and spontaneous splenic rupture. Fever is a very rare presentation of splenic angiosarcoma. Here we report the case of a 64-year-old man who presented with fever and anemia. A laparoscopic splenectomy was performed and revealed splenic angiosarcoma. The postoperative course was uneventful and the patient received 5 cycles of adjuvant chemotherapy with ifosfamide plus epirubicin. He remained disease free at 9 months after surgery. This is the first case of splenic angiosarcoma with fever as the initial presentation that was treated with laparoscopic splenectomy to be reported in the English literature.
authors.affiliation: Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Deng
authors.affiliation: Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Weilong
authors.initials: W
authors.lastname: Chang
authors.affiliation: Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Junhua
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Kaixiong
authors.initials: K
authors.lastname: Tao
authors.affiliation: Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000740:Anemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D015251:Epirubicin / Q000008:administration & dosage; D005334:Fever / Q000175:diagnosis / Q000209:etiology*; D006394:Hemangiosarcoma / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007150:Immunohistochemistry; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D013156:Splenectomy / Q000379:methods; D013160:Splenic Neoplasms / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D015251:Epirubicin; D007069:Ifosfamide
keywords: Splenic angiosarcoma; anemia; disease free; fever; splenectomy
references.citation: Int Surg. 1980 Jul-Aug;65(4):369-73
references.pmid: 7194868
references.citation: Vasa. 2012 Jan;41(1):57-62
references.pmid: 22247061
references.citation: J Med Case Rep. 2008 Apr 29;2:133
references.pmid: 18445294
references.citation: Med Pediatr Oncol. 2003 Jun;40(6):411-2
references.pmid: 12692821
references.citation: JSLS. 2006 Apr-Jun;10(2):199-205
references.pmid: 16882420
references.citation: Presse Med. 1991 Dec 21-28;20(44):2263
references.pmid: 1838167
references.citation: Radiology. 2005 Apr;235(1):106-15
references.pmid: 15749977
references.citation: JSLS. 2010 Jul-Sep;14(3):431-5
references.pmid: 21333203
references.citation: J Natl Med Assoc. 2000 Mar;92(3):143-6
references.pmid: 10745645
references.citation: J Clin Neurosci. 2008 Aug;15(8):927-9
references.pmid: 18411053
references.citation: J Surg Oncol. 2005 Dec 15;92(4):312-6
references.pmid: 16299797
references.citation: Indian J Med Paediatr Oncol. 2011 Oct;32(4):230-2
references.pmid: 22563160
references.citation: Mod Pathol. 2000 Sep;13(9):978-87
references.pmid: 11007038
references.citation: Pediatr Pathol. 1985;4(3-4):331-9
references.pmid: 3835556
references.citation: Acta Radiol. 1994 Sep;35(5):455-8
references.pmid: 8086253
references.citation: Am J Surg Pathol. 1993 Oct;17(10):959-70
references.pmid: 8372948
references.citation: Clin Imaging. 2001 May-Jun;25(3):192-6
references.pmid: 11679227
references.citation: Lancet Oncol. 2010 Oct;11(10):983-91
references.pmid: 20537949
references.citation: Med Pediatr Oncol. 1981;9(4):319-24
references.pmid: 7196486
references.citation: Ann Surg. 1998 Jul;228(1):35-9
references.pmid: 9671064
references.citation: Ann Diagn Pathol. 2005 Oct;9(5):289-92
references.pmid: 16198958
references.citation: Am J Surg. 2004 May;187(5):618-20
references.pmid: 15135677
references.citation: Surgery. 1998 Nov;124(5):839-43
references.pmid: 9823396
references.citation: Tumori. 2001 Nov-Dec;87(6):439-43
references.pmid: 11989602
references.citation: Arch Pathol Lab Med. 2005 Aug;129(8):1054-6
references.pmid: 16048401