title: Clinical Practice in the Use of Adjuvant Chemotherapy for Patients with Colon Cancer in South Korea: a Multi-Center, Prospective, Observational Study.
abstract: BACKGROUND
  Adjuvant chemotherapy is a crucial part of treatment for patients with locally advanced colon cancer. This study was conducted to investigate the actual practice in the use of adjuvant chemotherapy for patients with high-risk stage II or stage III colon cancer in South Korea.
  
  
  METHODS
  This was a 24-month open-label, prospective, observational study conducted at 12 centers across South Korea. Patients with high-risk stage II and stage III colon cancer receiving adjuvant chemotherapy after curative surgery were included, and data were collected at baseline, third, and sixth month.
  
  
  RESULTS
  A total of 246 patients were included in the analyses. Of five available regimens (FOLFOX, CAPOX, 5-FU/LV, capecitabine, and UFT/LV), FOLFOX was most commonly used (82.5%). Investigators indicated the "efficacy" as the major cause for selecting FOLFOX or CAPOX. For 5-FU/LV, capecitabine, or UFT/LV, the "safety" or "patient's characteristics (age, comorbidity, and stage)" was one of the most important selecting factors. Patients receiving 5-FU/LV, capecitabine, or UFT/LV had older age, worse PS and lower disease stage (stage II) than patients receiving FOLFOX or CAPOX. Hematologic toxicities were the most common cause of dose adjustment and treatment delay.
  
  
  CONCLUSIONS
  In South Korea, FOLFOX was the most commonly used regimen for adjuvant chemotherapy and its efficacy was the main cause for selecting this regimen. Patients receiving 5-FU/LV, capecitabine, or UFT/LV had older age, worse PS and lower disease stage (stage II) than patients receiving FOLFOX or CAPOX.
authors.affiliation: 1. Department of Internal Medicine, Kangnam Sacred-Heart Hospital, Hallym University College of Medicine, Seoul 150-950, Korea.
authors.forename: Jung Han
authors.initials: JH
authors.lastname: Kim
authors.affiliation: 2. Department of Surgery, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Moo Jun
authors.initials: MJ
authors.lastname: Baek
authors.affiliation: 3. Department of Surgery, Kosin University College of Medicine, Busan, Korea.
authors.forename: Byung-Kwon
authors.initials: BK
authors.lastname: Ahn
authors.affiliation: 4. Department of Surgery, Daegu Catholic University Medical Center, Catholic University of Daegu School of Medicine, Daegu, Korea.
authors.forename: Dae Dong
authors.initials: DD
authors.lastname: Kim
authors.affiliation: 5. Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Ik Yong
authors.initials: IY
authors.lastname: Kim
authors.affiliation: 6. Department of Surgery, College of Medicine, Chungnam National University, Daejeon, Korea.
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Kim
authors.affiliation: 7. Department of Surgery, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
authors.forename: Byung-Noe
authors.initials: BN
authors.lastname: Bae
authors.affiliation: 8. Department of Hemato-Oncology, Dongnam Institute of Radiological and Medical Sciences, Busan, Korea.
authors.forename: Bong-Gun
authors.initials: BG
authors.lastname: Seo
authors.affiliation: 9. Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea.
authors.forename: Sang Hun
authors.initials: SH
authors.lastname: Jung
authors.affiliation: 10. Department of Surgery, Inje University Sanggye Paik Hospital, Seoul, Korea.
authors.forename: Kwan Hee
authors.initials: KH
authors.lastname: Hong
authors.affiliation: 11. Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hungdai
authors.initials: H
authors.lastname: Kim
authors.affiliation: 12. Department of Surgery, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Dong Guk
authors.initials: DG
authors.lastname: Park
authors.affiliation: 13. Medical department of sanofi-aventis Korea, Seoul, Korea.
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Lee
keywords: 5-fluorouracil; Adjuvant chemotherapy; Capecitabine; Colon cancer; Oxaliplatin
references.citation: Int J Cancer. 2015 Mar 1;136(5):E359-86
references.pmid: 25220842
references.citation: J Clin Oncol. 2013 Jul 10;31(20):2600-6
references.pmid: 23733765
references.citation: Cancer Res Treat. 2015 Apr;47(2):127-41
references.pmid: 25761484
references.citation: J Clin Oncol. 2012 Jul 20;30(21):2624-34
references.pmid: 22665536
references.citation: Cancer Res Treat. 2014 Apr;46(2):124-30
references.pmid: 24851103
references.citation: Lancet Oncol. 2012 Dec;13(12):1225-33
references.pmid: 23168362
references.citation: Cancer Res Treat. 2012 Dec;44(4):219-26
references.pmid: 23341785
references.citation: Ann Oncol. 2003 Mar;14(3):395-9
references.pmid: 12598344
references.citation: J Clin Oncol. 2009 Jul 1;27(19):3109-16
references.pmid: 19451431
references.citation: J Clin Oncol. 2004 May 15;22(10):1797-806
references.pmid: 15067028
references.citation: N Engl J Med. 2005 Jun 30;352(26):2696-704
references.pmid: 15987918
references.citation: J Clin Oncol. 2007 Jun 1;25(16):2198-204
references.pmid: 17470851
references.citation: J Clin Oncol. 2011 Apr 10;29(11):1465-71
references.pmid: 21383294
references.citation: Cancer Chemother Pharmacol. 2015 Mar;75(3):639-43
references.pmid: 25630415
references.citation: Ann Surg Oncol. 2002 Dec;9(10):944-53
references.pmid: 12464585
references.citation: J Clin Oncol. 2012 Sep 20;30(27):3353-60
references.pmid: 22915656
references.citation: J Clin Oncol. 2011 Aug 20;29(24):3255-62
references.pmid: 21768462
references.citation: J Clin Oncol. 2011 Oct 1;29(28):3768-74
references.pmid: 21859995
references.citation: Ann Oncol. 2006 Sep;17(9):1347-59
references.pmid: 16524974
references.citation: JAMA. 2012 Apr 4;307(13):1383-93
references.pmid: 22474202
references.citation: Eur J Cancer. 2014 Sep;50(13):2231-40
references.pmid: 24958736
references.citation: World J Gastroenterol. 2015 May 7;21(17):5158-66
references.pmid: 25954089
references.citation: N Engl J Med. 2004 Jun 3;350(23):2343-51
references.pmid: 15175436