title: Estimating healthcare resource use associated with the treatment of metastatic melanoma in eight countries.
abstract: Objectives Studies reporting healthcare resourse use (HRU) for melanoma, one of the most costly cancers to treat, are limited. Using consistent, robust methodology, this study estimated HRU associated with the treatment of metastatic melanoma in eight countries. Methods Using published literature and clinician input, treatment phases were identified: active systemic treatment (pre-progression); disease progression; best supportive care (BSC)/palliative care; and terminal care. HRU elements were identified for each phase and estimates of the magnitude and frequency of use in clinical practice were obtained through country-specific Delphi panels, comprising healthcare professionals with experience in oncology (n = 8). Results Medical oncologists are the key care providers for patients with metastatic melanoma, although in Germany dermato-oncologists also lead care. During the active systemic treatment phase, each patient was estimated to require 0.83-2 consultations with a medical oncologist/month across countries; the median number of such assessments in 3 months was highest in Canada (range = 3.5-5) and lowest in France, the Netherlands and Spain (1). Resource use during the disease progression phase was intensive and similar across countries: all patients were estimated to consult with medical oncologists and 10-40% with a radiation oncologist; up to 40% were estimated to require a brain MRI scan. During the BSC/palliative care phase, all patients were estimated to consult with medical oncologists, and most to consult with a primary care physician (40-100%). Limitations Panelists were from centers of excellence, thus results may not reflect care within smaller hospitals; data obtained from experts may be less variable than data from broader clinical practice. Treatments for metastatic melanoma are continually emerging, thus some elements of our work could be superseded. Conclusions HRU estimates were substantial and varied across countries for some resources. These data could be used with country-specific costs to elucidate costs for the management of metastatic melanoma.
authors.affiliation: a PRMA Consulting , Fleet , UK ;
authors.forename: Jan
authors.initials: J
authors.lastname: McKendrick
authors.affiliation: a PRMA Consulting , Fleet , UK ;
authors.forename: Merel
authors.initials: M
authors.lastname: Gijsen
authors.affiliation: a PRMA Consulting , Fleet , UK ;
authors.forename: Casey
authors.initials: C
authors.lastname: Quinn
authors.affiliation: b Amgen Inc. , Thousand Oaks , CA , USA.
authors.forename: Beth
authors.initials: B
authors.lastname: Barber
authors.affiliation: b Amgen Inc. , Thousand Oaks , CA , USA.
authors.forename: Zhongyun
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D003697:Delphi Technique; D019468:Disease Management; D018450:Disease Progression; D005060:Europe; D005260:Female; D005102:Health Expenditures / Q000706:statistics & numerical data*; D006296:Health Services / Q000191:economics* / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000191:economics* / Q000473:pathology / Q000628:therapy; D009362:Neoplasm Metastasis; D010166:Palliative Care / Q000191:economics; D012878:Skin Neoplasms / Q000191:economics* / Q000473:pathology / Q000628:therapy; D013727:Terminal Care / Q000191:economics
keywords: Delphi consensus panel; Healthcare resource use; metastatic melanoma