title: Gene Therapy Strategies for Alzheimer's Disease: An Overview.
abstract: Key neuropathological hallmarks of Alzheimer's disease (AD) are extracellular amyloid plaques and intracellular accumulation of hyperphosphorylated Tau protein. The mechanisms underlying these neuropathological changes remain unclear. So far, research on AD therapy has had limited success in terms of symptomatic treatments although it has also had several failures for disease-modifying drugs. Gene transfer strategies to the brain have contributed to evaluate in animal models many interesting tracks, some of which should deserve clinical applications in AD patients in the future.
authors.affiliation: INSERM U1169/MIRCen CEA 92265 Fontenay aux Roses and Université Paris-Sud, Université Paris-Saclay , Orsay, France .
authors.forename: Sandro
authors.initials: S
authors.lastname: Alves
authors.affiliation: INSERM U1169/MIRCen CEA 92265 Fontenay aux Roses and Université Paris-Sud, Université Paris-Saclay , Orsay, France .
authors.forename: Romain
authors.initials: R
authors.lastname: Fol
authors.affiliation: INSERM U1169/MIRCen CEA 92265 Fontenay aux Roses and Université Paris-Sud, Université Paris-Saclay , Orsay, France .
authors.forename: Nathalie
authors.initials: N
authors.lastname: Cartier
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D053829:Amyloid Precursor Protein Secretases / Q000008:administration & dosage / Q000235:genetics; D000818:Animals; D057134:Antibodies, Neutralizing / Q000627:therapeutic use; D001057:Apolipoproteins E / Q000008:administration & dosage / Q000235:genetics; D016282:Aspartic Acid Endopeptidases / Q000008:administration & dosage / Q000235:genetics; D001921:Brain / Q000378:metabolism / Q000473:pathology; D019208:Brain-Derived Neurotrophic Factor / Q000008:administration & dosage / Q000235:genetics; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D018450:Disease Progression; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D016086:Lentivirus / Q000235:genetics; D051267:NF-E2-Related Factor 2 / Q000008:administration & dosage / Q000235:genetics; D058225:Plaque, Amyloid / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000235:genetics; D013002:Somatomedins / Q000008:administration & dosage / Q000235:genetics
chemical_list: D057134:Antibodies, Neutralizing; D001057:Apolipoproteins E; D019208:Brain-Derived Neurotrophic Factor; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D034741:RNA, Small Interfering; D013002:Somatomedins; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human