title: Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.
abstract: Foxp3-expressing regulatory T cells (Tregs) reside in tissues where they control inflammation and mediate tissue-specific functions. The skin of mice and humans contain a large number of Tregs; however, the mechanisms of how these cells function in skin remain largely unknown. In this article, we show that Tregs facilitate cutaneous wound healing. Highly activated Tregs accumulated in skin early after wounding, and specific ablation of these cells resulted in delayed wound re-epithelialization and kinetics of wound closure. Tregs in wounded skin attenuated IFN-γ production and proinflammatory macrophage accumulation. Upon wounding, Tregs induce expression of the epidermal growth factor receptor (EGFR). Lineage-specific deletion of EGFR in Tregs resulted in reduced Treg accumulation and activation in wounded skin, delayed wound closure, and increased proinflammatory macrophage accumulation. Taken together, our results reveal a novel role for Tregs in facilitating skin wound repair and suggest that they use the EGFR pathway to mediate these effects.
authors.affiliation: International Center for Infectiology Research, Lyon University, 69007 Lyon, France;
authors.forename: Audrey
authors.initials: A
authors.lastname: Nosbaum
authors.affiliation: Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143; and.
authors.forename: Nicolas
authors.identifier: http://orcid.org/0000-0002-5284-0082
authors.initials: N
authors.lastname: Prevel
authors.affiliation: Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143; and.
authors.forename: Hong-An
authors.initials: HA
authors.lastname: Truong
authors.affiliation: Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143; and.
authors.forename: Pooja
authors.identifier: http://orcid.org/0000-0001-8466-7424
authors.initials: P
authors.lastname: Mehta
authors.affiliation: Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143; and.
authors.forename: Monika
authors.initials: M
authors.lastname: Ettinger
authors.affiliation: Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143; and.
authors.forename: Tiffany C
authors.identifier: http://orcid.org/0000-0001-5517-089X
authors.initials: TC
authors.lastname: Scharschmidt
authors.affiliation: Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143; and.
authors.forename: Niwa H
authors.initials: NH
authors.lastname: Ali
authors.affiliation: Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143; and.
authors.forename: Mariela L
authors.identifier: http://orcid.org/0000-0002-9180-4789
authors.initials: ML
authors.lastname: Pauli
authors.affiliation: Department of Pathology, University of California, San Francisco, San Francisco, CA 94143.
authors.forename: Abul K
authors.initials: AK
authors.lastname: Abbas
authors.affiliation: Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143; and Michael.Rosenblum@ucsf.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Rosenblum
mesh_terms: D000818:Animals; D066246:ErbB Receptors / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014945:Wound Healing / Q000276:immunology*
chemical_list: C541485:EGFR protein, mouse; D066246:ErbB Receptors
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