title: Analgesic activity of alkyl piperidine derivatives.
abstract: Piperidine is the most significant scaffold which reveals therapeutic potential because of its conformationally flexible nature. During the course of present investigations synthetic quaternary salts of alkyl piperidine with various phenacyl bromides were explored for their possible analgesic activity. Compounds I analogs (1a-1f) and compound II analogs (IIa-IIf) showed varying degree of analgesic activity when compared with pethidine as standard and its duration by tail immersion method.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Sciences and Technology, Karachi, Pakistan.
authors.forename: Sarwat
authors.initials: S
authors.lastname: Jahan
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Shamim
authors.initials: S
authors.lastname: Akhtar
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Sciences and Technology, Karachi, Pakistan.
authors.forename: Arfa
authors.initials: A
authors.lastname: Kamil
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Nousheen
authors.initials: N
authors.lastname: Mushtaq
authors.affiliation: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
authors.forename: Zafar Saied
authors.initials: ZS
authors.lastname: Saify
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Arif
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D010880:Piperidines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D010880:Piperidines