title: Synthesis and cytotoxicity study of magnesium ferrite-gold core-shell nanoparticles.
abstract: In this work, the core-magnesium ferrite (MgFe2O4) nanoparticles were prepared by hydrothermal technique. Completed gold (Au) shell coating on the surfaces of MgFe2O4 nanoparticles was obtained by varying core/shell ratios via a reduction method. Phase identification, morphological evolution, optical properties, magnetic properties and cytotoxicity to mammalian cells of these MgFe2O4 core coated with Au nanoparticles were examined by using a combination of X-ray diffraction, scanning electron microscopy, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy, UV-visible spectroscopy (UV-vis), vibrating sample magnetometry and resazurin microplate assay techniques. In general, TEM images revealed different sizes of the core-shell nanoparticles generated from various core/shell ratios and confirmed the completed Au shell coating on MgFe2O4 core nanoparticles via suitable core/shell ratio with particle size less than 100 nm. The core-shell nanoparticle size and the quality of coating influence the optical properties of the products. The UV-vis spectra of complete coated MgFe2O4-Au core-shell nanoparticles exhibit the absorption bands in the near-Infrared (NIR) region indicating high potential for therapeutic applications. Based on the magnetic property measurement, it was found that the obtained MgFe2O4-Au core-shell nanoparticles still exhibit superparamagnetism with lower saturation magnetization value, compared with MgFe2O4 core. Both of MgFe2O4 and MgFe2O4-Au core-shell also showed in vitro non-cytotoxicity to mouse areola fibroblast (L-929) cell line.
authors.affiliation: Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
authors.forename: Jeeranan
authors.initials: J
authors.lastname: Nonkumwong
authors.affiliation: Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
authors.forename: Phakkhananan
authors.initials: P
authors.lastname: Pakawanit
authors.affiliation: Division of Biochemistry and Biochemical Technology, Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
authors.forename: Angkana
authors.initials: A
authors.lastname: Wipatanawin
authors.affiliation: Department of Physics, Faculty of Science, Kasetsart University, Bangkok 11900, Thailand.
authors.forename: Pongsakorn
authors.initials: P
authors.lastname: Jantaratana
authors.affiliation: Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
authors.forename: Supon
authors.initials: S
authors.lastname: Ananta
authors.affiliation: Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address: slaongnuan@yahoo.com.
authors.forename: Laongnuan
authors.initials: L
authors.lastname: Srisombat
mesh_terms: D000818:Animals; D002460:Cell Line; D005290:Ferric Compounds / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D017616:Magnesium Compounds / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; D017616:Magnesium Compounds; C001215:ferrite; D006046:Gold
keywords: Core-shell; Cytotoxicity; Gold; Magnesium ferrite; Magnetic properties; Nanoparticles