title: Interobserver and Intraobserver Reproducibility with Volume Dynamic Contrast Enhanced Computed Tomography (DCE-CT) in Gastroesophageal Junction Cancer.
abstract: The purpose of this study was to assess inter- and intra-observer reproducibility of three different analytic methods to evaluate quantitative dynamic contrast-enhanced computed tomography (DCE-CT) measures from gastroesophageal junctional cancer. Twenty-five DCE-CT studies with gastroesophageal junction cancer were selected from a previous longitudinal study. Three radiologists independently reviewed all scans, and one repeated the analysis eight months later for intraobserver analysis. Review of the scans consisted of three analysis methods: (I) Four, fixed small sized regions of interest (2-dimensional (2D) fixed ROIs) placed in the tumor periphery, (II) 2-dimensional regions of interest (2D-ROI) along the tumor border in the tumor center, and (III) 3-dimensional volumes of interest (3D-VOI) containing the entire tumor volume. Arterial flow, blood volume and permeability (k(trans)) were recorded for each observation. Inter- and intra-observer variability were assessed by Intraclass Correlation Coefficient (ICC) and Bland-Altman statistics. Interobserver ICC was excellent for arterial flow (0.88), for blood volume (0.89) and for permeability (0.91) with 3D-VOI analysis. The 95% limits of agreement were narrower for 3D analysis compared to 2D analysis. Three-dimensional volume DCE-CT analysis of gastroesophageal junction cancer provides higher inter- and intra-observer reproducibility with narrower limits of agreement between readers compared to 2D analysis.
authors.affiliation: Department of Radiology, University Hospital of Copenhagen, Rigshospitalet, DK-2100 Copenhagen, Denmark. mlundsgaard@dadlnet.dk.|Department of Radiology, Koege and Roskilde Hospital, DK-4000 Roskilde, Denmark. mlundsgaard@dadlnet.dk.
authors.forename: Martin
authors.initials: M
authors.lastname: Lundsgaard Hansen
authors.affiliation: Department of Radiology, University Hospital of Copenhagen, Rigshospitalet, DK-2100 Copenhagen, Denmark. eva.fallentin@regionh.dk.
authors.forename: Eva
authors.initials: E
authors.lastname: Fallentin
authors.affiliation: Department of Radiology, University Hospital of Copenhagen, Rigshospitalet, DK-2100 Copenhagen, Denmark. thomas.axelsen@regionh.dk.
authors.forename: Thomas
authors.initials: T
authors.lastname: Axelsen
authors.affiliation: Department of Radiology, University Hospital of Copenhagen, Rigshospitalet, DK-2100 Copenhagen, Denmark. carsten.lauridsen@regionh.dk.|Metropolitan University College, Radiography Education, Copenhagen, DK-2200 Copenhagen, Denmark. carsten.lauridsen@regionh.dk.
authors.forename: Carsten
authors.initials: C
authors.lastname: Lauridsen
authors.affiliation: Department of Radiology, University Hospital of Copenhagen, Rigshospitalet, DK-2100 Copenhagen, Denmark. rna@dadlnet.dk.
authors.forename: Rikke
authors.initials: R
authors.lastname: Norling
authors.affiliation: Department of Surgery, University Hospital of Copenhagen, Rigshospitalet, DK-2100 Copenhagen, Denmark. lars.bo.svendsen@regionh.dk.
authors.forename: Lars Bo
authors.initials: LB
authors.lastname: Svendsen
authors.affiliation: Department of Radiology, University Hospital of Copenhagen, Rigshospitalet, DK-2100 Copenhagen, Denmark. mbn@dadlnet.dk.
authors.forename: Michael Bachmann
authors.initials: MB
authors.lastname: Nielsen
keywords: CT perfusion; dynamic contrast enhanced computed tomography; gastroesophageal cancer; imaging biomarkers; reproducibility
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