title: Relationship between HER2 Proto-oncogene Status and Prognostic Factors of Breast Cancer in the West of Iran.
abstract: BACKGROUND
  Breast cancer is a very common health problem in Iranian women. The HER2-neu gene is a transmembrane receptor tyrosine kinase with homology to members of the EGF receptor family. The aim of this study was to investigate the association between HER2-neu oncogene status with prognostic factors of breast cancer in Kermanshah province, Iran.
  
  
  METHODS
  Relationship between HER2-neu and prognostic factors of 130 cases of breast cancer were evaluated during two years in Imam Reza hospital in Kermanshah, Iran. Data were analyzed using descriptive statistics and the T-test and Mann-Whitney U non-parametric test using SPSS 19.
  
  
  RESULTS
  The mean age for the patients was 46.0±8.0 years, all being female. Among the predictive factors for breast cancer were family history, stage of disease, involvement of the lymphovascular system, number of involved lymph nodes in axillaries, grading and hormone receptor status with HER2-neu oncogene had direct correlation and between factors, tumor location, patient age and histological characteristics and HER2-neu oncogene had no significant relationship. We found significant correlation between HER2 with ER and PR and also HER2 with ER, PR negative.
  
  
  CONCLUSIONS
  HER2-neu is risk factor that can be a good prognostic and also predictive factor. For these reasons, we recommend that it be evaluated for all types of BC.
authors.affiliation: Cancer Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran E-mail : Sadeghi_mkn@yahoo.com.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Amirifard
authors.forename: Edris
authors.initials: E
authors.lastname: Sadeghi
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Payandeh
authors.forename: Hossain
authors.initials: H
authors.lastname: Mohebbi
authors.forename: Masoud
authors.initials: M
authors.lastname: Sadeghi
authors.forename: Mansour
authors.initials: M
authors.lastname: Choubsaz
mesh_terms: D000328:Adult; D001365:Axilla / Q000473:pathology; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006801:Humans; D007492:Iran; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes / Q000235:genetics*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000090063:Proto-Oncogene Mas; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C000715470:MAS1 protein, human; C508053:ERBB2 protein, human