title: Eye-Movement Training Results in Changes in qEEG and NIH Stroke Scale in Subjects Suffering from Acute Middle Cerebral Artery Ischemic Stroke: A Randomized Control Trial.
abstract: BACKGROUND
  Eye-movement training (EMT) can induce altered brain activation and change the functionality of saccades with changes of the brain in general.
  
  
  OBJECTIVE
  To determine if EMT would result in changes in quantitative electroencephalogram (qEEG) and NIH Stroke Scale (NIHSS) in patients suffering from acute middle cerebral artery (MCA) infarction. Our hypothesis is that there would be positive changes in qEEG and NIHSS after EMT in patients suffering from acute MCA ischemic stroke.
  
  
  METHODS
  Double-blind randomized controlled trial.
  
  
  METHODS
  Thirty-four subjects with acute MCA ischemic stroke treated at university affiliated hospital intensive care unit.
  
  
  METHODS
  Subjects were randomized into a "control" group treated only with aspirin (125 mg/day) and a "treatment" group treated with aspirin (125 mg/day) and a subject-specific EMT.
  
  
  METHODS
  Delta-alpha ratio, power ratio index, and the brain symmetry index calculated by qEEG and NIHSS.
  
  
  RESULTS
  There was strong statistical and substantive significant improvement in all outcome measures for the group of stroke patients undergoing EMT. Such improvement was not observed for the "control" group, and there were no adverse effects.
  
  
  CONCLUSIONS
  The addition of EMT to a MCA ischemic stroke treatment paradigm has demonstrated statistically significant changes in outcome measures and is a low cost, safe, and effective complement to standard treatment.
authors.affiliation: Neurology, Carrick Institute, Cape Canaveral, FL, USA; Global Clinical Scholars Research Training Program (GCSRT), Harvard Medical School, Boston, MA, USA; Institute of Neurology and Neurosurgery, Havana, Cuba; Bedfordshire Centre for Mental Health Research, University of Cambridge, Cambridge, UK.
authors.forename: Frederick Robert
authors.initials: FR
authors.lastname: Carrick
authors.affiliation: Neurology, Carrick Institute, Cape Canaveral, FL, USA; Electrical and Computer Engineering, University of Wyoming, Laramie, WY, USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Oggero
authors.affiliation: Neurology, Carrick Institute, Cape Canaveral, FL, USA; Electrical and Computer Engineering, University of Wyoming, Laramie, WY, USA.
authors.forename: Guido
authors.initials: G
authors.lastname: Pagnacco
authors.affiliation: Neurology, Carrick Institute, Cape Canaveral, FL, USA; Electrical and Computer Engineering, University of Wyoming, Laramie, WY, USA.
authors.forename: Cameron H G
authors.initials: CH
authors.lastname: Wright
authors.affiliation: Neurology, Carrick Institute, Cape Canaveral, FL, USA; Institute of Neurology and Neurosurgery, Havana, Cuba.
authors.forename: Calixto
authors.initials: C
authors.lastname: Machado
authors.affiliation: Institute of Neurology and Neurosurgery , Havana , Cuba.
authors.forename: Genco
authors.initials: G
authors.lastname: Estrada
authors.affiliation: Institute of Neurology and Neurosurgery , Havana , Cuba.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Pando
authors.affiliation: Institute of Neurology and Neurosurgery , Havana , Cuba.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Cossio
authors.affiliation: Institute of Neurology and Neurosurgery , Havana , Cuba.
authors.forename: Carlos
authors.initials: C
authors.lastname: Beltrán
keywords: NIHSS scores; eye moment therapy; ischemic stroke; qEEG; saccades; stroke rehabilitation
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