title: Treprostinil Iontophoresis Improves Digital Blood Flow during Local Cooling in Systemic Sclerosis.
abstract: BACKGROUND
  Severe Raynaud's syndrome and DUs are the most prevalent manifestations of SSc peripheral microvascular disease. We tested whether treprostinil iontophoresis on the finger pad of patients with SSc would improve digital blood flow during hand cooling.
  
  
  METHODS
  Eleven patients with limited cutaneous SSc underwent a double-blinded iontophoresis of treprostinil (2.56 × 10(-4) M during two hours) and placebo (NaCl 0.9%) on two finger pads. Then, the hand was inserted for 30 minutes in a fenestrated cooling box at 8 °C, and skin blood flow was recorded continuously using LSCI.
  
  
  RESULTS
  During the local cooling, CVC was significantly higher at the treprostinil site than at the placebo site and remained higher 30 minutes after the test.
  
  
  CONCLUSIONS
  In patients with SSc, digital treprostinil iontophoresis shifts skin blood flow upward during local cooling of the hand and during the initial rewarming phase. Digital treprostinil iontophoresis should now be tested in larger scale studies.
authors.affiliation: University Grenoble Alpes, Grenoble, France.|Clinical Pharmacology Unit, INSERM CIC1406, Grenoble University Hospital, Grenoble, France.|INSERM, U1042, HP2, Grenoble, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Gaillard-Bigot
authors.affiliation: University Grenoble Alpes, Grenoble, France.|Clinical Pharmacology Unit, INSERM CIC1406, Grenoble University Hospital, Grenoble, France.|INSERM, U1042, HP2, Grenoble, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Roustit
authors.affiliation: INSERM, U1042, HP2, Grenoble, France.|Vascular Medicine Department, Grenoble University Hospital, Grenoble, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Blaise
authors.affiliation: Clinical Pharmacology Unit, INSERM CIC1406, Grenoble University Hospital, Grenoble, France.|INSERM, U1042, HP2, Grenoble, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Cracowski
authors.affiliation: Vascular Medicine Department, Grenoble University Hospital, Grenoble, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Seinturier
authors.affiliation: Vascular Medicine Department, Grenoble University Hospital, Grenoble, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Imbert
authors.affiliation: Vascular Medicine Department, Grenoble University Hospital, Grenoble, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Carpentier
authors.affiliation: University Grenoble Alpes, Grenoble, France.|Clinical Pharmacology Unit, INSERM CIC1406, Grenoble University Hospital, Grenoble, France.|INSERM, U1042, HP2, Grenoble, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Cracowski
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D011464:Epoprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007478:Iontophoresis; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000503:physiopathology / Q000628:therapy; D012867:Skin / Q000098:blood supply / Q000503:physiopathology
chemical_list: D011464:Epoprostenol; C427248:treprostinil
keywords: Raynaud's phenomenon; laser speckle contrast imaging; microcirculation; prostacyclin; systemic sclerosis