title: [Inflammatory diseases of scrotal organs in patients with brucellosis: Improvement of therapy].
abstract: OBJECTIVE
  To evaluate the efficacy of cycloferon used in the combination treatment of scrotal inflammatory diseases (SID) in patients with brucellosis.
  
  
  METHODS
  A total of 150 male patients with chronic brucellosis (CB) were examined. Inquiry, questioning, physical and ultrasound examinations, and spermiogram analysis were used to detect of diseases of the reproductive system. Twenty-two CB patients with SID were examined over time (before and after cycle therapy). In Group 1, combination therapy included 2 cycles of five intramuscular injections of cycloferon 0.25 g in each at a 10-day interval. In Group 2, a package of therapeutic measures meets the generally accepted standards. and Incorporation of cycloferon into the combination therapy of SID patients with CB positively affected the time course of clinical changes and spermatogenesis, declines the number of SID exacerbations, improved quality of life, and failed to cause side effects.
  
  
  CONCLUSIONS
  The findings allow us to recommend cycloferon as the drug of choice in treating CB patients with SID.
authors.affiliation: V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia, Saratov, Russia; Saratov Research Institute of Rural Hygiene, Saratov, Russia.
authors.forename: E P
authors.initials: EP
authors.lastname: Lyapina
authors.affiliation: V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia, Saratov, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Shuldyakov
authors.affiliation: V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia, Saratov, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Evdokimov
authors.affiliation: I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
authors.forename: P V
authors.initials: PV
authors.lastname: Glybochko
mesh_terms: D000166:Acridines / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D002006:Brucellosis / Q000150:complications / Q000188:drug therapy*; D004823:Epididymitis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007369:Interferon Inducers / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009920:Orchitis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000166:Acridines; D007369:Interferon Inducers; C026430:10-carboxymethyl-9-acridanone