title: [Clinical significance of detecting t(11;14) by fluorescence in situ hybridization for the diagnosis of 7 patients with atypical mantle cell lymphoma].
abstract: OBJECTIVE
  To study the clinical features and diagnosis of 7 patients with atypical mantle cell lymphoma (MCL).
  
  
  METHODS
  The 7 MCL patients were misdiagnosed as chronic lymphocytic leukemia (CLL) due to a score of 4 for their immunophenotypes. The clinical features and diagnosis of such patients were retrospectively analyzed.
  
  
  RESULTS
  Six patients had superficial lymphadenectasis but their lymph nodes could not be palpated. All 7 patients were as stage IV considering bone marrow infiltration. Scores of immunophenotype of CLL were 4, and interphase fluorescence in situ hybridization (FISH) for t(11;14) were positive in all patients.
  
  
  CONCLUSIONS
  Some MCL patients have clinical features similar to CLL. Interphase FISH can play an important role in the diagnosis of MCL.
authors.affiliation: Department of Hematology, the People's Hospital of Taizhou, Nantong University, Taizhou, Jiangsu 225300, China. lijianyonglm@medmail.com.cn.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhu
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Wu
authors.forename: Lei
authors.initials: L
authors.lastname: Fan
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Jianyong
authors.initials: J
authors.lastname: Li
mesh_terms: D000368:Aged; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic