title: Assessment of Impact of Weight Loss on Left and Right Ventricular Functions and Value of Tissue Doppler Echocardiography in Obese Patients.
abstract: OBJECTIVE
  In our study, we aimed to evaluate the effect of weight loss on left and right ventricular functions in obese patients.
  
  
  METHODS
  Thirty patients with a BMI greater than 30 kg/m(2) and without any exclusion criteria were included in the study. Left ventricular systolic and diastolic functions were assessed with conventional and tissue Doppler echocardiography (TDE). At the end of 3 months, echocardiographic examination was repeated in patients with weight loss for cardiac function evaluation and it was compared to the baseline echocardiographic parameters.
  
  
  RESULTS
  At the end of 3 months of weight loss period, conventional Doppler echocardiography revealed an improvement in diastolic functions with an increase in mitral E-wave, a decrease in mitral A-wave and an increase in E/A ratio. Deceleration time and isovolumetric relaxation time were ascertained shortened and Tei index decreased. TDE showed an increase in left ventricular lateral wall systolic wave (Sm) and E-wave velocity (Em). Mitral septal annular isovolumetric acceleration time (IVA), Sm and Em, were found to be increased, whereas Tei index was ascertained reduced. Right ventricular tissue Doppler examination following weight loss revealed an increase in RV- IVA, RV-Sm, and RV-Em, and a decrease in Tei index.
  
  
  CONCLUSIONS
  We disclosed that left ventricular structural changes and diastolic dysfunction occur in obese patients, and by weight loss, these abnormalities may be reversible which we demonstrated both by conventional and TDE. In addition, obesity might impair RV function as well, and we observed an enhancement in right ventricular functions by weight loss.
authors.affiliation: Department of Cardiology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Isa Oner
authors.initials: IO
authors.lastname: Yuksel
authors.affiliation: Department of Cardiology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Akar Bayram
authors.affiliation: Department of Cardiology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Koklu
authors.affiliation: Department of Cardiology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Cagin Mustafa
authors.initials: CM
authors.lastname: Ureyen
authors.affiliation: Department of Cardiology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Kucukseymen
authors.affiliation: Department of Cardiology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Sakir
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Department of Cardiology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Bozkurt
mesh_terms: D000328:Adult; D004452:Echocardiography / Q000379:methods*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications / Q000000981:diagnostic imaging* / Q000517:prevention & control*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D016896:Treatment Outcome; D018754:Ventricular Dysfunction / Q000000981:diagnostic imaging* / Q000209:etiology / Q000517:prevention & control*; D016276:Ventricular Function; D061217:Weight Reduction Programs
keywords: left ventricular diastolic function; left ventricular systolic function; obesity; tissue Doppler echocardiography