title: Trichomonas vaginalis infection and risk of advanced prostate cancer.
abstract: BACKGROUND
  The epidemiologic evidence for an association of Trichomonas vaginalis (Tv) with overall prostate cancer is mixed, but some studies suggest Tv may increase risk of more aggressive disease. The aim of this study was to assess whether Tv serostatus is associated with advanced or fatal prostate cancer.
  
  
  METHODS
  A total of 146 men with advanced (metastatic or fatal) prostate cancer and 181 age-matched controls were selected from two prior population-based, case-control studies. Tv serostatus was determined with the same laboratory methods used in previous epidemiologic studies. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic regression to compare Tv serostatus in prostate cancer cases and controls adjusted for potential confounders.
  
  
  RESULTS
  The seroprevalence of Tv in controls was 23%. Tv serostatus was not associated with an increased risk of metastatic or fatal prostate cancer (ORs < 1).
  
  
  CONCLUSIONS
  Our study does not support an increased risk of advanced or fatal prostate cancer in men seropositive for Tv.
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.|Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.
authors.forename: Irene M
authors.initials: IM
authors.lastname: Shui
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Kolb
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Christi
authors.initials: C
authors.lastname: Hanson
authors.affiliation: Division of Public Health Sciences and the Alvin J Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Siobhan
authors.initials: S
authors.lastname: Sutcliffe
authors.affiliation: Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.|Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Rider
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.|Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stanford
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000150:complications* / Q000175:diagnosis; D012307:Risk Factors; D012720:Severity of Illness Index; D014245:Trichomonas Infections / Q000150:complications*; D014246:Trichomonas vaginalis / Q000302:isolation & purification*
keywords: Trichomonas vaginalis; prostate cancer; sexually transmitted infections
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