title: Handgrip strength is associated with metabolic syndrome among middle-aged and elderly community-dwelling persons.
abstract: The association of low muscle strength with cardio-metabolic risks remains controversial. The present study included 742 men aged 70 ± 9 years and 937 women aged 70 ± 8 years from a rural village. We examined the cross-sectional relationship between relative muscle strength defined by handgrip strength (HGS)/body weight (BW) ratio, and metabolic syndrome (MetS) based on the modified criteria of the National Cholesterol Education Program's Adult Treatment Panel (NCEP-ATP) III report and its components. Of these, 203 men (27.4%) and 448 women (47.8%) had MetS. In men, increasing quartile of HGS/BW ratio was significantly and independently associated with high waist circumference {odds ratio, 0.31; 95% confidence interval (CI), 0.24-0.41} and elevated triglyceridemia (0.71, 0.59-0.86). In women, it was also significantly and independently associated with high waist circumference (0.41; 0.36-0.48), high blood pressure (0.78; 0.66-0.92), Low HDL-cholesterolemia (0.84; 0.73-0.98) and elevated triglyceridemia (0.65; 0.53-0.79). In both genders, the prevalence of MetS significantly decreased in relation to increasing HGS/BW ratio. After adjustment for age, smoking status, drinking status, LDL-C, estimated glomerular filtration ratio (eGFR), and medication, the respective odds ratio (95% CI) for the quartile of HGS/BW ratio for MetS was 1.00, 0.54 (0.34-0.85), 0.32 (0.19-0.53), and 0.16 (0.09-0.29) in men, and 1.00, 0.76 (0.50-1.16), 0.33 (0.22-0.51), and 0.16 (0.10-0.25) in women. These results suggest that HGS/BW ratio was significantly and negatively associated with an increased risk of cardio-metabolic disorders in Japanese-community dwelling persons.
authors.affiliation: a Department of Community Medicine , Ehime University Graduate School of Medicine , Ehime , Japan and.|b Department of Internal Medicine , Seiyo Municipal Nomura Hospital , Ehime , Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kawamoto
authors.affiliation: a Department of Community Medicine , Ehime University Graduate School of Medicine , Ehime , Japan and.|b Department of Internal Medicine , Seiyo Municipal Nomura Hospital , Ehime , Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ninomiya
authors.affiliation: b Department of Internal Medicine , Seiyo Municipal Nomura Hospital , Ehime , Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kasai
authors.affiliation: b Department of Internal Medicine , Seiyo Municipal Nomura Hospital , Ehime , Japan.
authors.forename: Tomo
authors.initials: T
authors.lastname: Kusunoki
authors.affiliation: b Department of Internal Medicine , Seiyo Municipal Nomura Hospital , Ehime , Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohtsuka
authors.affiliation: a Department of Community Medicine , Ehime University Graduate School of Medicine , Ehime , Japan and.
authors.forename: Teru
authors.initials: T
authors.lastname: Kumagi
authors.affiliation: a Department of Community Medicine , Ehime University Graduate School of Medicine , Ehime , Japan and.
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D001835:Body Weight; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000453:epidemiology; D050171:Dyslipidemias / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000378:metabolism; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D015228:Hypertriglyceridemia / Q000188:drug therapy / Q000453:epidemiology*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D057187:Independent Living; D007564:Japan / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D016017:Odds Ratio; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; C517652:hemoglobin A1c protein, human
keywords: Cardio-metabolic risk; component; handgrip strength; hypertension; metabolic syndrome