title: A patient with complex multiple genomic ALK alterations.
authors.affiliation: Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Shawn J
authors.initials: SJ
authors.lastname: Rice
authors.affiliation: Department of Radiology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Jamis-Dow
authors.affiliation: Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Abendroth
authors.affiliation: Foundation Medicine, Cambridge, Massachusetts, USA.
authors.forename: Siraj
authors.initials: S
authors.lastname: Ali
authors.affiliation: Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Salah
authors.initials: S
authors.lastname: Almokadem
authors.affiliation: Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Chandra P
authors.initials: CP
authors.lastname: Belani
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics* / Q000556:secondary; D000368:Aged; D000077548:Anaplastic Lymphoma Kinase; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics* / Q000556:secondary; D018797:Cell Cycle Proteins / Q000235:genetics; D003062:Codon; D000077547:Crizotinib; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D023281:Genomics; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D048670:MAP Kinase Kinase 4 / Q000235:genetics; D008869:Microtubule-Associated Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011720:Pyrazoles / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use; D011859:Radiography; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D012261:Ribonucleoproteins / Q000235:genetics; D012697:Serine Endopeptidases / Q000235:genetics; D000072668:Splicing Factor U2AF; D014157:Transcription Factors / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics; D016896:Treatment Outcome; D000092468:Bromodomain Containing Proteins
chemical_list: D000077548:Anaplastic Lymphoma Kinase; D018797:Cell Cycle Proteins; D003062:Codon; D000077547:Crizotinib; D004268:DNA-Binding Proteins; D011495:Histone-Lysine N-Methyltransferase; D048670:MAP Kinase Kinase 4; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011725:Pyridines; D020794:Receptor Protein-Tyrosine Kinases; D012261:Ribonucleoproteins; D012697:Serine Endopeptidases; D000072668:Splicing Factor U2AF; D014157:Transcription Factors; C112476:ARID1A protein, human; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins; C114495:TP53TG1 protein, human; C076753:U2AF1 protein, human; C521636:SETD2 protein, human; C000626173:ALK protein, human; C482559:MAP2K4 protein, human; C415585:EML4 protein, human
keywords: Lung Cancer; Non-Small Cell Lung Cancer