title: A Comparative Study of Surgical Splenectomy, Partial Splenic Embolization, and High-Intensity Focused Ultrasound for Hypersplenism.
abstract: OBJECTIVE
  This study compared splenectomy, partial splenic embolization, and high-intensity focused ultrasound (HIFU) therapy, which represent the traditional, mature, and newest methods for improving thrombocytopenia in hypersplenism, respectively.
  
  
  METHODS
  A total of 69 patients with hypersplenism were treated with surgical splenectomy (n = 31), HIFU (n = 26), or partial splenic embolization (n = 12). They were followed closely for at least 6 months, and the effectiveness of the treatments was compared.
  
  
  RESULTS
  Among the 3 groups, splenectomy was the most effective treatment for increasing peripheral blood cells. Embolization reduced the operating time and hospital stay, but HIFU was relatively safer and less invasive than the other treatments.
  
  
  CONCLUSIONS
  High-intensity focused ultrasound has wide clinical indications for hypersplenism and may be safer than other treatment methods. Therefore, it is a good alternative procedure for patients with a high surgical risk.
authors.affiliation: Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (J.Z., X.C., X.H., C.H.); Clinical Center for Tumor Therapy, Second Clinical College and Affiliated Hospital, Chongqing Medical University, Chongqing, China (H.Z.); and Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (C.H.).
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (J.Z., X.C., X.H., C.H.); Clinical Center for Tumor Therapy, Second Clinical College and Affiliated Hospital, Chongqing Medical University, Chongqing, China (H.Z.); and Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (C.H.).
authors.forename: Xijun
authors.initials: X
authors.lastname: Chen
authors.affiliation: Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (J.Z., X.C., X.H., C.H.); Clinical Center for Tumor Therapy, Second Clinical College and Affiliated Hospital, Chongqing Medical University, Chongqing, China (H.Z.); and Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (C.H.).
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Hu
authors.affiliation: Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (J.Z., X.C., X.H., C.H.); Clinical Center for Tumor Therapy, Second Clinical College and Affiliated Hospital, Chongqing Medical University, Chongqing, China (H.Z.); and Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (C.H.).
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (J.Z., X.C., X.H., C.H.); Clinical Center for Tumor Therapy, Second Clinical College and Affiliated Hospital, Chongqing Medical University, Chongqing, China (H.Z.); and Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (C.H.). drhe@zju.edu.cn.
authors.forename: Chao
authors.initials: C
authors.lastname: He
mesh_terms: D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D006971:Hypersplenism / Q000175:diagnosis* / Q000628:therapy*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D012189:Retrospective Studies; D013156:Splenectomy / Q000379:methods*; D016896:Treatment Outcome
keywords: high-intensity focused ultrasound; hypersplenism; partial splenic embolization; splenectomy