title: Effectiveness and safety of methylphenidate and atomoxetine for attention deficit hyperactivity disorder: a systematic review.
abstract: OBJECTIVE
  To assess and compare the effectiveness and safety of methylphenidate immediate-release tablets (IR-MPH), methylphenidate controlled-release tablets (OROS-MPH) and atomoxetine (AHC) for attention deficit hyperactivity disorder (ADHD) in Chinese children.
  
  
  METHODS
  Randomized or clinical controlled trials on the effectiveness and safety of IR-MPH, OROS-MPH and AHC for ADHD were searched in electronic databases of CNKI, VIP, CBMDISC online, PubMed, Embase and MEDLINE. Two reviewers independently extracted the data and assessed the quality of the included literatures.
  
  
  RESULTS
  Eight trials were finally included. IR-MPH, OROS-MPH and AHC were effective for ADHD. OROS-MPH was superior to IR-MPH in the improvement of peer relationship, CGI-I score, mother satisfaction and psychosomatic problems. There were no significant differences in the effectiveness between the AHC and IR-MPH groups. The adverse events related to the therapy with IR-MPH, OROS-MPH or AHC were mild and total incidence rates of adverse events was not significantly different among the three groups.
  
  
  CONCLUSIONS
  The effectiveness of OROS-MPH for the treatment of ADHD is probably superior to IR-MPH, and the effectiveness of AHC and IR-MPH is similar. The three drugs have equivalent safety and good tolerance.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Xiao-Zhen
authors.initials: XZ
authors.lastname: Lv
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Shu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Yao-Wen
authors.initials: YW
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Si-Yan
authors.initials: SY
authors.lastname: Zhan
keywords: Methylphenidate; atomoxetine; attention deficit hyperactivity disorder; child; systematic review
references.citation: Acta Psychiatr Scand. 2010 Oct;122(4):271-84
references.pmid: 20491715
references.citation: J Child Adolesc Psychopharmacol. 2006 Aug;16(4):441-55
references.pmid: 16958569
references.citation: J Atten Disord. 2008 Jan;11(4):470-81
references.pmid: 17934184
references.citation: Clin Psychol Rev. 2008 Jun;28(5):783-800
references.pmid: 18068284
references.citation: Pediatr Clin North Am. 1999 Oct;46(5):915-27, vii
references.pmid: 10570696
references.citation: Nervenarzt. 2008 Jul;79(7):771-81
references.pmid: 18553066
references.citation: Atten Defic Hyperact Disord. 2012 Jun;4(2):85-91
references.pmid: 22328340
references.citation: Pediatr Ann. 2002 Aug;31(8):514-22
references.pmid: 12174766
references.citation: Can J Clin Pharmacol. 2006 Winter;13(1):e50-62
references.pmid: 16456216
references.citation: J Am Acad Child Adolesc Psychiatry. 2006 Aug;45(8):919-27
references.pmid: 16865034
references.citation: J Am Acad Child Adolesc Psychiatry. 2005 Jul;44(7):647-55
references.pmid: 15968233
references.citation: J Am Acad Child Adolesc Psychiatry. 2007 Sep;46(9):1119-27
references.pmid: 17712235
references.citation: J Child Adolesc Psychopharmacol. 2006 Jun;16(3):351-6
references.pmid: 16768642
references.citation: J Child Adolesc Psychopharmacol. 2007 Jun;17(3):356-66
references.pmid: 17630869
references.citation: Am J Psychiatry. 2007 Jun;164(6):942-8
references.pmid: 17541055
references.citation: Neurology. 2005 Dec 27;65(12):1941-9
references.pmid: 16380617
references.citation: Zhongguo Dang Dai Er Ke Za Zhi. 2008 Aug;10(4):471-4
references.pmid: 18706164
references.citation: Chin Med J (Engl). 2011 Oct;124(20):3269-74
references.pmid: 22088519
references.citation: Atten Defic Hyperact Disord. 2010 Dec;2(4):267-89
references.pmid: 21432612