title: Apolipoprotein E receptor 2 Gene Polymorphisms Associated with Dyslipidemia among Thai Population.
abstract: BACKGROUND
  Dyslipidemia is an abnormal amount of lipids and/or lipoproteins in the blood. It is a major risk factor of coronary heart disease and atherosclerosis.
  
  
  OBJECTIVE
  This study investigated two single nucleotide polymorphisms (SNPs) in the apolipoprotein E receptor 2 (ApoER2) gene in association with risk of dyslipidemia in the Thai patients.
  
  
  METHODS
  Four hundred blood samples including dyslipidemia patient (200) and unrelated normal control (200) were included in this study. Serum lipids were examined. DNAs were extracted and genotyped by using polymerase chain reaction (PCR) followed by high-resolution melting (HRM) analysis. The differences in genotype distribution between patient and normal control were assessed by Chi-square test of the SPSS software version 11.5.
  
  
  RESULTS
  The data analysis revealed that two SNPs (rs3737984 and rs2297660) in ApoER2 gene had significant association with dyslipidemia. The rs3 737984 showed significant association at p-value = 0.001, in which A alleles informed the decreased risk of dyslipidemia [odds ratio and 95% CI of A allele, 0.42 (0.28-0.65)]. In contrast, the rs2297660 exhibited strongest association with an increase risk ofdyslipidemia [p-value = 0.001, odds ratio and 95% CI for theA allele was 2.38 (1.49-3.80)].
  
  
  CONCLUSIONS
  The rs2297660 may be used as biomarker for the risk of dyslipidemia in Thai ethnic.
authors.forename: Polphet
authors.initials: P
authors.lastname: Thongket
authors.forename: Kankanit
authors.initials: K
authors.lastname: Rattanathanawan
authors.forename: Weeranuch
authors.initials: W
authors.lastname: Seesom
authors.forename: Wasana
authors.initials: W
authors.lastname: Sukhumsirichart
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D050171:Dyslipidemias / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D026502:LDL-Receptor Related Proteins; D008055:Lipids; C098773:low density lipoprotein receptor-related protein 8