title: Three-dimensional parametric mapping in quantitative micro-CT imaging of post-surgery femoral head-neck samples: preliminary results.
abstract: Osteoporosis and pathological increased occurrence of fractures are an important public health problem. They may affect patients' quality of life and even increase mortality of osteoporotic patients, and consequently represent a heavy economic burden for national healthcare systems. The adoption of simple and inexpensive methods for mass screening of population at risk may be the key for an effective prevention. The current clinical standards of diagnosing osteoporosis and assessing the risk of an osteoporotic bone fracture include dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) for the measurement of bone mineral density (BMD). Micro-computed tomography (micro-CT) is a tomographic imaging technique with very high resolution allowing direct quantification of cancellous bone microarchitecture. The Authors performed micro-CT analysis of the femoral heads harvested from 8 patients who have undergone surgery for hip replacement for primary and secondary degenerative disease to identify possible new morphometric parameters based on the analysis of the distribution of intra-subject microarchitectural parameters through the creation of parametric images. Our results show that the micro-architectural metrics commonly used may not be sufficient for the realistic assessment of bone microarchitecture of the femoral head in patients with hip osteoarthritis. The innovative micro-CT approach considers the entire femoral head in its physiological shape with all its components like cartilage, cortical layer and trabecular region. The future use of these methods for a more detailed study of the reaction of trabecular bone for the internal fixation or prostheses would be desirable.
authors.affiliation: II Orthopaedic and Traumatologic Clinic, University of Pisa, Pisa, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Giannotti
authors.affiliation: II Orthopaedic and Traumatologic Clinic, University of Pisa, Pisa, Italy.
authors.forename: Vanna
authors.initials: V
authors.lastname: Bottai
authors.affiliation: Institute of Clinical Physiology, IFC-CNR, Pisa, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Panetta
authors.affiliation: II Orthopaedic and Traumatologic Clinic, University of Pisa, Pisa, Italy.
authors.forename: Gaia
authors.initials: G
authors.lastname: De Paola
authors.affiliation: Institute of Clinical Physiology, IFC-CNR, Pisa, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Tripodi
authors.affiliation: II Orthopaedic and Traumatologic Clinic, University of Pisa, Pisa, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Citarelli
authors.affiliation: II Orthopaedic and Traumatologic Clinic, University of Pisa, Pisa, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Dell'Osso
authors.affiliation: II Orthopaedic and Traumatologic Clinic, University of Pisa, Pisa, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Lazzerini
authors.affiliation: Institute of Clinical Physiology, IFC-CNR, Pisa, Italy.
authors.forename: Piero Antonio
authors.initials: PA
authors.lastname: Salvadori
authors.affiliation: II Orthopaedic and Traumatologic Clinic, University of Pisa, Pisa, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Guido
keywords: DEXA; osteoporosis; quantitative micro-CT
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