title: The effect of MDMA on sensitivity to reinforcement rate.
abstract: Administration of (±)3,4-methylenedioxymethamphetamine (MDMA) causes memory errors by increasing proactive interference. This might occur because MDMA alters sensitivity to reinforcement. The current 2 experiments investigated this directly by assessing the acute (Experiment 1) and chronic (Experiment 2) effects of MDMA on sensitivity to reinforcement. We presented 5 pairs of concurrent variable interval schedules within each session and calculated sensitivity to reinforcement for 3 acute doses of MDMA. In contrast to the related drug, d-amphetamine, and in spite of producing reductions in response rate, MDMA did not reduce sensitivity to reinforcement rate. Chronic administration of a fixed dose of MDMA following each session reduced response rate but did not affect sensitivity to reinforcement rate. In combination with previous research, these results indicate that related drugs may have different effects on sensitivity to reinforcement and that these effects should be considered when interpreting disruptions to operant task performance caused by drug administration. (PsycINFO Database Record
authors.affiliation: Department of Psychology.
authors.forename: Celia
authors.initials: C
authors.lastname: Lie
authors.affiliation: School of Psychology.
authors.forename: Anne C
authors.initials: AC
authors.lastname: Macaskill
authors.affiliation: School of Psychology.
authors.forename: David N
authors.initials: DN
authors.lastname: Harper
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D003913:Dextroamphetamine; D004305:Dose-Response Relationship, Drug; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology*; D051381:Rats; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology
chemical_list: D018817:N-Methyl-3,4-methylenedioxyamphetamine; D003913:Dextroamphetamine