title: Hedgehog signalling.
abstract: The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extends across many fields, from evo-devo to cancer research and regenerative medicine. Here, and in the accompanying poster, we provide an outline of the current understanding of Hh signalling mechanisms, highlighting the similarities and differences between species.
authors.affiliation: Developmental and Biomedical Genetics Laboratory, Institute of Molecular and Cell Biology, Agency of Science, Technology and Research (A* STAR), Singapore, 138673 Singapore.
authors.forename: Raymond Teck Ho
authors.initials: RT
authors.lastname: Lee
authors.affiliation: Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 636921 Singapore.
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Developmental and Biomedical Genetics Laboratory, Institute of Molecular and Cell Biology, Agency of Science, Technology and Research (A* STAR), Singapore, 138673 Singapore Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 636921 Singapore Department of Medicine, Imperial College London, London SW7 2AZ, UK pingham@ntu.edu.sg.
authors.forename: Philip W
authors.initials: PW
authors.lastname: Ingham
mesh_terms: D000818:Animals; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D007448:Invertebrates / Q000378:metabolism; D015398:Signal Transduction; D014714:Vertebrates / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins
keywords: Drosophila; Hedgehog signalling; Vertebrate