title: Synthesis and Characterization of Impurities in the Production Process of Lopinavir.
abstract: Lopinavir is an antiretroviral drug used for the inhibition of HIV protease. Four related substances of lopinavir were observed during the manufacturing process of lopinavir in the laboratory and they were identified. The present work describes the origin, synthesis, characterization, and control of these related substances.
authors.affiliation: Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad-502329, Telangana State, India; Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, India.
authors.forename: Ambati V
authors.initials: AV
authors.lastname: Raghava Reddy
authors.affiliation: Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad-502329, Telangana State, India; Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Garaga
authors.affiliation: Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad-502329, Telangana State, India.
authors.forename: Chandiran
authors.initials: C
authors.lastname: Takshinamoorthy
authors.affiliation: Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, India.
authors.forename: Andra
authors.initials: A
authors.lastname: Naidu
keywords: Lopinavir; Related substances; Synthesis and Characterization of impurities
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