title: Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome.
abstract: This review summarizes a recent finding regarding the intrinsic canonical Notch signaling pathway in regulating normal ocular surface morphogenesis and its role in the pathogenesis of goblet cell deficiency-associated keratoconjunctivitis sicca (KCS, or dry eye). Specifically, we used novel transgenic mice to investigate the mechanism of how the Notch1 activation may serve as the upstream control of expression of transcription factors Krüppel-like factors 4 or 5 (Klf4 or Klf5) which in turn controls goblet cell differentiation and activates mucin 5/ac synthesis during ocular surface morphogenesis.
authors.affiliation: Edith J. Crawley Vision Research Center/Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, 45267-0838, USA. liuchia@iu.edu.|Present Address: Opt511, Indiana University School of Optometry, 800 E. Atwater Avenue, Bloomington, IN, USA. liuchia@iu.edu.
authors.forename: Chia-Yang
authors.initials: CY
authors.lastname: Liu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003226:Congresses as Topic; D003228:Conjunctiva / Q000166:cytology; D004268:DNA-Binding Proteins / Q000378:metabolism; D015352:Dry Eye Syndromes / Q000378:metabolism / Q000503:physiopathology*; D020397:Goblet Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism; D051379:Mice; D051881:Receptor, Notch1 / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; C000715467:KLF4 protein, human; C000715468:Klf4 protein, mouse; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; C430872:MAML1 protein, human; D051881:Receptor, Notch1; D014157:Transcription Factors
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