title: The Effects of Amnestic Mild Cognitive Impairment on Go/NoGo Semantic Categorization Task Performance and Event-Related Potentials.
abstract: We examined the effects of amnestic mild cognitive impairment (aMCI) on behavioral (response times and error rates) and scalp-recorded event-related potential (ERP) measures of response execution and inhibition, using Go/NoGo tasks involving basic and superordinate semantic categorization. Twenty-five aMCI (16 F; 68.5±8 years) and 25 age- and gender-matched normal control subjects (16 F; 65.4±7.1 years) completed two visual Go/NoGo tasks. In the single car task, responses were made based on single exemplars of a car (Go) and a dog (NoGo) (basic). In the object animal task, responses were based on multiple exemplars of objects (Go) and animals (NoGo) (superordinate). The aMCI subjects had higher commission errors on the NoGo trials compared to the control subjects, whereas both groups had comparable omission errors and reaction times during the Go trials. The aMCI subjects had significantly prolonged N2 ERP latency during Go and NoGo trials across tasks compared to the controls. Both groups showed similar categorization effects and response type effects in N2/P3 ERP latencies and P3 amplitude. Our findings indicate that altered early neural processing indexed by N2 latency distinguishes subjects with aMCI from controls during the Go/NoGo task. Prolonged Go-N2 latency in aMCI appears to precede behavioral changes in response execution, whereas prolonged NoGo-N2 latency underlies behavioral deterioration in response inhibition.
authors.affiliation: Department of Speech and Hearing Science, University of Illinois at Urbana-Champaign, Champaign, IL, USA.|Neuroscience Program, University of Illinois at Urbana-Champaign, Champaign, IL, USA.|Center for BrainHealth, The University of Texas at Dallas, Dallas, TX, USA.
authors.forename: Raksha A
authors.initials: RA
authors.lastname: Mudar
authors.affiliation: Center for BrainHealth, The University of Texas at Dallas, Dallas, TX, USA.
authors.forename: Hsueh-Sheng
authors.initials: HS
authors.lastname: Chiang
authors.affiliation: Center for BrainHealth, The University of Texas at Dallas, Dallas, TX, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Eroh
authors.affiliation: Neuroscience Program, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
authors.forename: Lydia T
authors.initials: LT
authors.lastname: Nguyen
authors.affiliation: Center for BrainHealth, The University of Texas at Dallas, Dallas, TX, USA.
authors.forename: Mandy J
authors.initials: MJ
authors.lastname: Maguire
authors.affiliation: Center for BrainHealth, The University of Texas at Dallas, Dallas, TX, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Spence
authors.affiliation: Department of Speech and Hearing Science, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
authors.forename: Fanting
authors.initials: F
authors.lastname: Kung
authors.affiliation: Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kraut
authors.affiliation: Center for BrainHealth, The University of Texas at Dallas, Dallas, TX, USA.
authors.forename: John
authors.initials: J
authors.lastname: Hart
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000503:physiopathology / Q000523:psychology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D060825:Cognitive Dysfunction / Q000503:physiopathology / Q000523:psychology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology
keywords: Categorization; Go/NoGo; cognition; electroencephalography; event-related potentials; mild cognitive impairment; semantics