title: Higher Body Mass Index and Increased Prevalence of Paranasal Sinus Disease.
abstract: BACKGROUND
  We hypothesized that higher body mass index (BMI) was associated with increased prevalence of paranasal sinus disease and examined the hypothesis in Japanese adults.
  
  
  METHODS
  This was a cross-sectional study including 1350 Japanese adults aged 40 years or more who participated in a health check-up program focusing on brain diseases and metabolic syndrome. Participants were divided into quartiles of BMI levels. Paranasal sinus disease was confirmed by a head MRI scan. The association between BMI and paranasal sinus disease was examined using logistic regression analysis, which was adjusted for age, sex, waist:hip ratio, hemoglobin A1c, systolic blood pressure, smoking status, alcohol intake, and white blood cell count.
  
  
  RESULTS
  Of the 1350 participants, 151 (11.2%) had paranasal sinus disease. In relation to those in the lowest quartile of BMI, the odds ratios of having the disease among those in the 2nd, 3rd, and 4th quartiles of BMI were 1.89 (95% confidence interval [CI], 1.03-3.48), 2.26 (95% CI, 1.20-4.23) and 2.26 (95% CI, 1.14-4.51), respectively. When BMI was analysed as a continuous variable, an increase of one unit in BMI was significantly associated with increased odds of having the disease, with an OR of 1.08 (95% CI, 1.01-1.16).
  
  
  CONCLUSIONS
  The present study suggests that patients with higher BMI are more likely to have paranasal sinus disease.
authors.affiliation: Division of General Internal Medicine, Department of Internal Medicine, Tokai University Hachioji Hospital.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kabeya
authors.forename: Kiyoe
authors.initials: K
authors.lastname: Kato
authors.forename: Masuomi
authors.initials: M
authors.lastname: Tomita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Katsuki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Oikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D010254:Paranasal Sinus Diseases / Q000453:epidemiology*; D015995:Prevalence
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