title: Heme oxygenase-1 alleviates cigarette smoke-induced restenosis after vascular angioplasty by attenuating inflammation in rat model.
abstract: Cigarette smoke is not only a profound independent risk factor of atherosclerosis, but also aggravates restenosis after vascular angioplasty. Heme oxygenase-1 (HO-1) is an endogenous antioxidant and cytoprotective enzyme. In this study, we investigated whether HO-1 upregulating by hemin, a potent HO-1 inducer, can protect against cigarette smoke-induced restenosis in rat's carotid arteries after balloon injury. Results showed that cigarette smoke exposure aggravated stenosis of the lumen, promoted infiltration of inflammatory cells, and induced expression of inflammatory cytokines and adhesion molecules after balloon-induced carotid artery injury. HO-1 upregulating by hemin treatment reduced these effects of cigarette smoke, whereas the beneficial effects were abolished in the presence of Zincprotoporphyrin IX, an HO-1 inhibitor. To conclude, hemin has potential therapeutic applications in the restenosis prevention after the smokers' vascular angioplasty.
authors.affiliation: Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan, DongCheng District, Beijing 100730, China.
authors.forename: Leng
authors.initials: L
authors.lastname: Ni
authors.affiliation: Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan, DongCheng District, Beijing 100730, China.
authors.forename: Zhanqi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan, DongCheng District, Beijing 100730, China.
authors.forename: Genhuan
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan, DongCheng District, Beijing 100730, China.
authors.forename: Tianjia
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan, DongCheng District, Beijing 100730, China.
authors.forename: Xinnong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan, DongCheng District, Beijing 100730, China. Electronic address: liucw@vip.sina.com.
authors.forename: Changwei
authors.initials: C
authors.lastname: Liu
mesh_terms: D017130:Angioplasty; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D020212:Carotid Artery Injuries / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D016207:Cytokines / Q000096:biosynthesis; D006083:Graft Occlusion, Vascular / Q000139:chemically induced* / Q000517:prevention & control*; D051547:Heme Oxygenase-1 / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006427:Hemin / Q000096:biosynthesis; D007249:Inflammation / Q000517:prevention & control; D008297:Male; D011524:Protoporphyrins / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012906:Smoke / Q000009:adverse effects*; D012907:Smoking / Q000009:adverse effects; D062789:Tobacco Products
chemical_list: D000975:Antioxidants; D015815:Cell Adhesion Molecules; D016207:Cytokines; D011524:Protoporphyrins; D012906:Smoke; C017803:zinc protoporphyrin; D006427:Hemin; D051547:Heme Oxygenase-1
keywords: Angioplasty; Cigarette smoke; Heme oxygenase-1; Hemin; Inflammatory reaction; Restenosis