title: Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose.
abstract: Cationic amphiphiles derived from trehalose have been synthesized; trehalose analogues substituted with n-pentyl or n-hexyl ethers exhibited membrane disrupting activities against clinically important Gram positive and Gram negative bacteria and fungi. Our results demonstrate that trehalose is a useful disaccharide scaffold for the development of broad-spectrum antimicrobial and antifungal agents.
authors.affiliation: School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel. mfridman@post.tau.ac.il.
authors.forename: P
authors.initials: P
authors.lastname: Shaul
authors.forename: R I
authors.initials: RI
authors.lastname: Benhamou
authors.forename: I M
authors.initials: IM
authors.lastname: Herzog
authors.forename: S
authors.initials: S
authors.lastname: Louzoun Zada
authors.forename: Y
authors.initials: Y
authors.lastname: Ebenstein
authors.forename: M
authors.initials: M
authors.lastname: Fridman
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000166:cytology / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D005658:Fungi / Q000166:cytology / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000166:cytology / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008958:Models, Molecular; D009181:Mycoses / Q000188:drug therapy; D014199:Trehalose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D014199:Trehalose