title: Hypertension and aging.
abstract: Hypertension is a highly prevalent condition with numerous health risks, and the incidence of hypertension is greatest among older adults. Traditional discussions of hypertension have largely focused on the risks for cardiovascular disease and associated events. However, there are a number of collateral effects, including risks for dementia, physical disability, and falls/fractures which are increasingly garnering attention in the hypertension literature. Several key mechanisms--including inflammation, oxidative stress, and endothelial dysfunction--are common to biologic aging and hypertension development and appear to have key mechanistic roles in the development of the cardiovascular and collateral risks of late-life hypertension. The objective of the present review is to highlight the multi-dimensional risks of hypertension among older adults and discuss potential strategies for treatment and future areas of research for improving overall care for older adults with hypertension.
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA. Electronic address: tbuford@ufl.edu.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Buford
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D019468:Disease Management; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D018384:Oxidative Stress; D012307:Risk Factors
keywords: Antihypertensive; Blood pressure; Cardiovascular; Cognition; Disability; Falls
references.citation: JAMA Intern Med. 2014 Apr;174(4):588-95
references.pmid: 24567036
references.citation: JAMA. 2015 May 19;313(19):1963-4
references.pmid: 25988465
references.citation: Am J Cardiol. 2003 Sep 1;92(5):522-8
references.pmid: 12943870
references.citation: J Clin Endocrinol Metab. 2001 Mar;86(3):1154-9
references.pmid: 11238501
references.citation: Annu Rev Med. 2000;51:245-70
references.pmid: 10774463
references.citation: Dis Mon. 2010 Mar;56(3):106-47
references.pmid: 20189499
references.citation: Neurobiol Aging. 2000 Jan-Feb;21(1):49-55
references.pmid: 10794848
references.citation: J Nutr Health Aging. 2009 Dec;13(10):881-9
references.pmid: 19924348
references.citation: Int J Womens Health. 2014 Jan 24;6:131-9
references.pmid: 24493934
references.citation: Free Radic Biol Med. 2009 Nov 1;47(9):1239-53
references.pmid: 19628035
references.citation: JAMA Intern Med. 2015 Jun;175(6):989-95
references.pmid: 25685919
references.citation: Hypertension. 2007 Dec;50(6):1026-32
references.pmid: 18025294
references.citation: J Gerontol B Psychol Sci Soc Sci. 1999 Sep;54(5):S262-70
references.pmid: 10542828
references.citation: Curr Hypertens Rep. 2013 Aug;15(4):304-12
references.pmid: 23832761
references.citation: Ren Fail. 2010 May;32(4):475-9
references.pmid: 20446787
references.citation: Lancet. 2005 Jan 15-21;365(9455):217-23
references.pmid: 15652604
references.citation: Sports Med. 1985 Nov-Dec;2(6):389-412
references.pmid: 2866577
references.citation: Maturitas. 1997 Jan;26(1):63-71
references.pmid: 9032749
references.citation: Life Sci. 2000 Jun 8;67(3):291-300
references.pmid: 10983873
references.citation: J Geriatr Cardiol. 2011 Dec;8(4):230-42
references.pmid: 22783310
references.citation: Hypertension. 1986 May;8(5):438-43
references.pmid: 3699883
references.citation: Am J Hypertens. 2003 Jun;16(6):429-33
references.pmid: 12799089
references.citation: Physiology (Bethesda). 2013 Sep;28(5):330-58
references.pmid: 23997192
references.citation: N Engl J Med. 2010 Jul 22;363(4):301-4
references.pmid: 20551152
references.citation: J Gerontol. 1956 Jul;11(3):298-300
references.pmid: 13332224
references.citation: J Gerontol. 1991 Sep;46(5):M164-70
references.pmid: 1890282
references.citation: JAMA Intern Med. 2013 May 27;173(10):934
references.pmid: 23712409
references.citation: J Am Soc Hypertens. 2013 Nov-Dec;7(6):420-5
references.pmid: 23910010
references.citation: J Gerontol A Biol Sci Med Sci. 2009 Sep;64(9):994-1001
references.pmid: 19535785
references.citation: N Engl J Med. 1988 Dec 29;319(26):1701-7
references.pmid: 3205267
references.citation: J Am Geriatr Soc. 2013 May;61(5):776-81
references.pmid: 23631352
references.citation: Mov Disord. 2006 Jul;21(7):950-7
references.pmid: 16541455
references.citation: J Gerontol A Biol Sci Med Sci. 2000 Nov;55(11):M691-7
references.pmid: 11078100
references.citation: Cardiovasc Diabetol. 2009;8:18
references.pmid: 19327149
references.citation: J Hypertens. 2010 Apr;28(4):806-16
references.pmid: 20027123
references.citation: Age (Dordr). 2013 Aug;35(4):1061-75
references.pmid: 22639176
references.citation: Brain Behav Immun. 2007 Aug;21(6):736-45
references.pmid: 17467231
references.citation: JAMA. 2014 Dec 17;312(23):2551-61
references.pmid: 25514304
references.citation: Am J Med. 2003 Oct 15;115(6):429-35
references.pmid: 14563498
references.citation: Lancet. 2006 Apr 15;367(9518):1262-70
references.pmid: 16631882
references.citation: Ageing Res Rev. 2010 Oct;9(4):369-83
references.pmid: 20438881
references.citation: Am J Epidemiol. 1993 Feb 1;137(3):342-54
references.pmid: 8452142
references.citation: J Am Soc Nephrol. 2008 Jul;19(7):1371-8
references.pmid: 18400940
references.citation: Clin Chem. 1997 May;43(5):855-6
references.pmid: 9166249
references.citation: Ageing Res Rev. 2011 Jul;10(3):319-29
references.pmid: 21145432
references.citation: Hypertension. 2015 Feb;65(2):252-6
references.pmid: 25368028
references.citation: Vasc Health Risk Manag. 2015;11:311-6
references.pmid: 26089677
references.citation: Cell Immunol. 2015 Apr;294(2):95-101
references.pmid: 25498375
references.citation: Circ Res. 1966 Oct;19(4):851-8
references.pmid: 5917853
references.citation: MMWR Morb Mortal Wkly Rep. 2008 Mar 7;57(9):225-9
references.pmid: 18322444
references.citation: J Am Geriatr Soc. 2012 Jan;60(1):136-41
references.pmid: 22150209
references.citation: J Alzheimers Dis. 2014;39(2):271-82
references.pmid: 24164735
references.citation: Hypertension. 1992 Jun;19(6 Pt 1):508-19
references.pmid: 1592445
references.citation: Hypertension. 2003 Oct;42(4):811-7
references.pmid: 12913063
references.citation: Int Psychogeriatr. 2008 Feb;20(1):32-9
references.pmid: 18072982
references.citation: Med Sci Sports Exerc. 2001 Jun;33(6 Suppl):S446-51; discussion S452-3
references.pmid: 11427769
references.citation: J Hypertens. 2010 Jul;28(7):1506-14
references.pmid: 20404744
references.citation: J Nutr Health Aging. 2010 Jun;14(6):457-60
references.pmid: 20617288
references.citation: Osteoporos Int. 2013 Oct;24(10):2649-57
references.pmid: 23612794
references.citation: Front Aging Neurosci. 2014 May 09;6:88
references.pmid: 24847262
references.citation: Science. 2011 Jul 29;333(6042):540-3
references.pmid: 21798924
references.citation: Stroke. 2008 Apr;39(4):1233-9
references.pmid: 18292379
references.citation: JAMA. 2009 Aug 26;302(8):849-57
references.pmid: 19706858
references.citation: Cancer Lett. 2006 May 8;236(1):13-23
references.pmid: 15978720
references.citation: Clin Sci (Lond). 2013 Oct;125(7):311-8
references.pmid: 23746374
references.citation: Age Ageing. 2006 Sep;35 Suppl 2:ii37-ii41
references.pmid: 16926202
references.citation: Eur J Neurol. 2014 Feb;21(2):253-e9
references.pmid: 24128182
references.citation: Am Heart J. 2009 Mar;157(3):442-9
references.pmid: 19249413
references.citation: Plant Foods Hum Nutr. 2013 Sep;68(3):279-92
references.pmid: 23881465
references.citation: Stroke. 2006 Jan;37(1):33-7
references.pmid: 16339468
references.citation: Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):56-67
references.pmid: 24616371
references.citation: Appl Physiol Nutr Metab. 2008 Jun;33(3):429-33
references.pmid: 18461094
references.citation: Int J Sports Med. 2008 Jan;29(1):40-4
references.pmid: 17614015
references.citation: J Am Coll Cardiol. 2010 Nov 9;56(20):1668-76
references.pmid: 21050978
references.citation: Age (Dordr). 2013 Jun;35(3):705-18
references.pmid: 22453933
references.citation: Neurology. 2003 Jul 8;61(1):76-80
references.pmid: 12847160
references.citation: Nat Rev Neurosci. 2006 May;7(5):335-46
references.pmid: 16760914
references.citation: Geriatr Gerontol Int. 2014 Feb;14 Suppl 1:69-75
references.pmid: 24450563
references.citation: Bone. 2011 Oct;49(4):824-9
references.pmid: 21700003
references.citation: Neurology. 2011 Oct 18;77(16):1543-50
references.pmid: 21975197
references.citation: Arch Cardiovasc Dis. 2008 Mar;101(3):181-9
references.pmid: 18477946
references.citation: Clin Chim Acta. 2004 Jun;344(1-2):195-200
references.pmid: 15149889
references.citation: Am J Geriatr Pharmacother. 2011 Dec;9(6):364-77
references.pmid: 22078863
references.citation: J Gerontol A Biol Sci Med Sci. 2010 Oct;65(10):1093-100
references.pmid: 20581339
references.citation: Hypertension. 2015 Aug;66(2):317-23
references.pmid: 26056337
references.citation: Antioxid Redox Signal. 2014 Jan 1;20(1):102-20
references.pmid: 23472597
references.citation: J Int Med Res. 2013 Oct;41(5):1408-17
references.pmid: 24051019
references.citation: Exp Gerontol. 2008 Feb;43(2):45-52
references.pmid: 17703905
references.citation: Int J Obes Relat Metab Disord. 1995 Oct;19 Suppl 4:S5-8
references.pmid: 8581095
references.citation: Curr Med Chem. 2007;14(13):1389-97
references.pmid: 17584051
references.citation: J Clin Endocrinol Metab. 1994 Sep;79(3):707-11
references.pmid: 8077350
references.citation: PLoS One. 2014;9(1):e86902
references.pmid: 24489804
references.citation: J Gerontol A Biol Sci Med Sci. 2001 Oct;56(10):B426-31
references.pmid: 11584027
references.citation: Circulation. 2006 Apr 18;113(15):1888-904
references.pmid: 16618833
references.citation: Mech Ageing Dev. 1999 Nov;111(2-3):97-106
references.pmid: 10656529
references.citation: Science. 2005 Jul 15;309(5733):481-4
references.pmid: 16020738
references.citation: Mech Ageing Dev. 2007 Jan;128(1):83-91
references.pmid: 17118425
references.citation: J Clin Hypertens (Greenwich). 2011 Apr;13(4):301-4
references.pmid: 21466630
references.citation: Alzheimers Res Ther. 2013 Sep 06;5(5):43
references.pmid: 24010759
references.citation: Kidney Int. 2014 Sep;86(3):469-71
references.pmid: 25168498
references.citation: Nucleic Acids Res. 2007;35(22):7417-28
references.pmid: 17913751
references.citation: J Appl Physiol (1985). 2012 Mar;112(5):892-7
references.pmid: 22174390
references.citation: Hypertension. 2010 Feb;55(2):277-83, 6p following 283
references.pmid: 20008675
references.citation: Pharmacogenomics. 2013 May;14(7):723-6
references.pmid: 23651020
references.citation: J Lab Clin Med. 1997 Mar;129(3):300-8
references.pmid: 9042815
references.citation: Ann Intern Med. 2006 Oct 3;145(7):538-43
references.pmid: 17015872
references.citation: Sports Med. 2004;34(5):293-306
references.pmid: 15107008
references.citation: Ageing Res Rev. 2014 Jul;16:12-31
references.pmid: 24862109
references.citation: Med Sci Sports Exerc. 2002 Jun;34(6):972-9
references.pmid: 12048324
references.citation: Circulation. 2009 Mar 10;119(9):1284-92
references.pmid: 19237660
references.citation: Ageing Res Rev. 2014 Nov;18:132-47
references.pmid: 25311590
references.citation: Alzheimers Dement. 2012 Jan;8(1):14-21
references.pmid: 22265588
references.citation: Exerc Sport Sci Rev. 2007 Jan;35(1):35-9
references.pmid: 17211192
references.citation: Expert Opin Drug Metab Toxicol. 2011 Mar;7(3):257-66
references.pmid: 21244343
references.citation: Blood. 2008 Aug 15;112(4):1022-7
references.pmid: 18535201
references.citation: Lancet Neurol. 2003 Jan;2(1):15-21
references.pmid: 12849297
references.citation: Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H10-20
references.pmid: 18456730
references.citation: J Alzheimers Dis. 2015;45(4):1237-45
references.pmid: 25697699
references.citation: Drugs Aging. 2014 Dec;31(12):897-910
references.pmid: 25323058
references.citation: Exp Neurol. 2015 Oct;272:97-108
references.pmid: 25987538
references.citation: Arch Neurol. 1999 Mar;56(3):303-8
references.pmid: 10190820
references.citation: Br J Nutr. 1999 May;81(5):383-8
references.pmid: 10615210
references.citation: Neuroepidemiology. 2000 May-Jun;19(3):113-20
references.pmid: 10705229
references.citation: Acta Clin Belg. 2013 Mar-Apr;68(2):107-12
references.pmid: 23967718
references.citation: Clin Pharmacol Ther. 2013 Aug;94(2):207-10
references.pmid: 23588301
references.citation: Nutr Res Rev. 2012 Dec;25(2):207-22
references.pmid: 22874455
references.citation: Exp Gerontol. 2004 May;39(5):687-99
references.pmid: 15130663
references.citation: Acta Physiol Scand. 1985 Mar;123(3):285-91
references.pmid: 2998155
references.citation: Am J Hypertens. 2016 Feb;29(2):202-16
references.pmid: 26137952
references.citation: Biochem Pharmacol. 2006 Nov 30;72(11):1605-21
references.pmid: 16889756
references.citation: Circ Res. 2007 Jun 8;100(11):1659-66
references.pmid: 17478731
references.citation: Int J Sports Med. 2003 Oct;24(7):492-8
references.pmid: 12968206
references.citation: Exp Gerontol. 2003 Jan-Feb;38(1-2):13-25
references.pmid: 12543257
references.citation: Age Ageing. 2010 Sep;39(5):609-16
references.pmid: 20573778
references.citation: Ann N Y Acad Sci. 1998 Nov 20;854:102-17
references.pmid: 9928424
references.citation: Clin Interv Aging. 2015;10:687-93
references.pmid: 25914527
references.citation: JAMA Neurol. 2014 Oct;71(10):1218-27
references.pmid: 25090106
references.citation: J Hypertens. 2006 Mar;24(3):581-9
references.pmid: 16467662
references.citation: J Am Geriatr Soc. 1995 Nov;43(11):1214-21
references.pmid: 7594154
references.citation: Clin Exp Hypertens. 2005 Jan;27(1):71-82
references.pmid: 15773231
references.citation: J Hum Hypertens. 1997 Aug;11(8):507-14
references.pmid: 9322832
references.citation: Mol Cancer Res. 2006 Apr;4(4):221-33
references.pmid: 16603636
references.citation: Diabetes Care. 2010 Apr;33(4):804-10
references.pmid: 20097779
references.citation: Arch Neurol. 2001 Dec;58(12):1985-92
references.pmid: 11735772
references.citation: BMJ. 2009;339:b4460
references.pmid: 19903980
references.citation: Trends Cardiovasc Med. 2015 Apr;25(3):228-39
references.pmid: 25560975
references.citation: Age (Dordr). 2010 Jun;32(2):209-22
references.pmid: 20431988
references.citation: J Am Geriatr Soc. 2002 Dec;50(12):1947-54
references.pmid: 12473005
references.citation: Chem Biol Interact. 1995 May 19;96(2):203-6
references.pmid: 7728908
references.citation: Am J Hypertens. 2016 Feb;29(2):185-93
references.pmid: 26137951
references.citation: Clin Adv Hematol Oncol. 2007 Jan;5(1):39-40
references.pmid: 17339825
references.citation: Am J Epidemiol. 1990 Jun;131(6):1028-37
references.pmid: 2343855
references.citation: Curr Opin Rheumatol. 2007 Jan;19(1):67-73
references.pmid: 17143099
references.citation: Am J Epidemiol. 2013 Aug 1;178(3):418-25
references.pmid: 23548756
references.citation: Arch Neurol. 2004 May;61(5):668-72
references.pmid: 15148142
references.citation: J Am Geriatr Soc. 2012 Jul;60(7):1244-52
references.pmid: 22726232
references.citation: Calcif Tissue Int. 2009 Feb;84(2):103-11
references.pmid: 19067019
references.citation: Ann N Y Acad Sci. 2009 Oct;1177:140-50
references.pmid: 19845616
references.citation: Expert Rev Neurother. 2011 Jul;11(7):1057-75
references.pmid: 21721921
references.citation: J Gerontol A Biol Sci Med Sci. 1998 Mar;53(2):M112-9
references.pmid: 9520917
references.citation: Ageing Res Rev. 2009 Jan;8(1):18-30
references.pmid: 18692159
references.citation: Calcif Tissue Int. 2013 Mar;92(3):217-27
references.pmid: 23192372
references.citation: Rejuvenation Res. 2006 Spring;9(1):143-8
references.pmid: 16608411
references.citation: Neurology. 2002 Aug 13;59(3):371-8
references.pmid: 12177370
references.citation: J Am Geriatr Soc. 2011 Mar;59(3):390-7
references.pmid: 21391929
references.citation: JAMA. 2011 Jan 5;305(1):50-8
references.pmid: 21205966
references.citation: J Am Geriatr Soc. 2002 Aug;50(8):1405-10
references.pmid: 12164998
references.citation: J Clin Endocrinol Metab. 2008 May;93(5):1952-8
references.pmid: 18285417
references.citation: Pharmacogenomics J. 2005;5(6):352-8
references.pmid: 16103896
references.citation: J Am Geriatr Soc. 2012 Jan;60(1):77-85
references.pmid: 22211568
references.citation: J Bone Miner Res. 1997 Jan;12(1):24-35
references.pmid: 9240722
references.citation: J Physiol. 2012 May 1;590(9):2069-79
references.pmid: 22351633
references.citation: Am J Physiol Regul Integr Comp Physiol. 2003 Aug;285(2):R277-97
references.pmid: 12855411
references.citation: Mol Cell Endocrinol. 2013 Sep 25;378(1-2):15-22
references.pmid: 22564510
references.citation: Ann Intern Med. 2011 Sep 6;155(5):300-8
references.pmid: 21893623
references.citation: J Hypertens. 1998 Mar;16(3):291-303
references.pmid: 9557922
references.citation: JAMA. 2013 Dec 25;310(24):2609-10
references.pmid: 24322396
references.citation: Hypertension. 2004 Apr;43(4):791-6
references.pmid: 14967837
references.citation: Lymphokine Cytokine Res. 1993 Aug;12(4):225-30
references.pmid: 8218595
references.citation: J Gerontol A Biol Sci Med Sci. 2012 Jan;67(1):17-27
references.pmid: 21636833
references.citation: J Gerontol A Biol Sci Med Sci. 2013 Aug;68(8):929-37
references.pmid: 23250002
references.citation: Lancet. 2002 Mar 16;359(9310):926-30
references.pmid: 11918911
references.citation: Curr Opin Clin Nutr Metab Care. 2003 May;6(3):295-9
references.pmid: 12690262
references.citation: J Am Geriatr Soc. 2000 Jul;48(7):807-10
references.pmid: 10894321
references.citation: Nutr Neurosci. 2014 Nov;17(6):241-51
references.pmid: 24192577
references.citation: Arch Intern Med. 2002 Nov 11;162(20):2333-41
references.pmid: 12418947
references.citation: Arch Intern Med. 2007 Aug 13-27;167(15):1676-85
references.pmid: 17698692
references.citation: Alzheimers Dement. 2005 Jul;1(1):30-7
references.pmid: 19595813
references.citation: J Bone Miner Res. 2009 Feb;24(2):241-50
references.pmid: 18847324
references.citation: Free Radic Biol Med. 2004 Jan 15;36(2):226-32
references.pmid: 14744634
references.citation: Coron Artery Dis. 2004 Sep;15(6):331-6
references.pmid: 15346091
references.citation: J Appl Physiol (1985). 1991 Nov;71(5):2004-11
references.pmid: 1761503
references.citation: Aging Cell. 2009 Jun;8(3):226-38
references.pmid: 19245678
references.citation: Aging Ment Health. 2010 May;14(4):386-95
references.pmid: 20455113
references.citation: Diabetes. 2006 Jun;55(6):1813-8
references.pmid: 16731847
references.citation: FASEB J. 2008 Jul;22(7):2465-75
references.pmid: 18256306
references.citation: Med Sci Sports Exerc. 2004 Jul;36(7):1132-9
references.pmid: 15235316
references.citation: Front Biosci. 2008;13:3661-75
references.pmid: 18508463
references.citation: Am J Hypertens. 1995 Oct;8(10 Pt 1):978-86
references.pmid: 8845079
references.citation: N Engl J Med. 1997 Oct 30;337(18):1279-84
references.pmid: 9345078
references.citation: Clin Geriatr Med. 2009 May;25(2):289-301
references.pmid: 19555873
references.citation: Neurology. 2002 Jul 23;59(2):198-205
references.pmid: 12136057
references.citation: Psychol Med. 2009 Jan;39(1):3-11
references.pmid: 18570697
references.citation: JAMA. 2010 Apr 14;303(14):1354-5
references.pmid: 20388884
references.citation: Eur J Immunol. 1993 Sep;23(9):2375-8
references.pmid: 8370415
references.citation: Epidemiology. 2011 Sep;22(5):646-59
references.pmid: 21705906
references.citation: Hypertens Res. 2014 Aug;37(8):772-8
references.pmid: 24671015
references.citation: Biochem Biophys Res Commun. 2014 Dec 5;455(1-2):113-8
references.pmid: 25450701
references.citation: Am J Hypertens. 2011 Feb;24(2):209-17
references.pmid: 21088669
references.citation: Arch Gerontol Geriatr. 2011 May-Jun;52(3):e204-9
references.pmid: 21144603
references.citation: Circulation. 2015 Jan 27;131(4):e29-322
references.pmid: 25520374
references.citation: Int J Biochem Cell Biol. 2013 Oct;45(10):2288-301
references.pmid: 23845738
references.citation: JAMA. 2006 Apr 12;295(14):1681-7
references.pmid: 16609090
references.citation: Life Sci. 1992;51(25):1953-6
references.pmid: 1453878
references.citation: JAMA. 2006 May 3;295(17):2018-26
references.pmid: 16670410
references.citation: JAMA. 2001 Jul 18;286(3):327-34
references.pmid: 11466099
references.citation: Cell. 2014 Jun 19;157(7):1515-26
references.pmid: 24949965
references.citation: Blood Cells Mol Dis. 2011 Feb 15;46(2):147-50
references.pmid: 21185752
references.citation: J Gen Intern Med. 2007 Nov;22(11):1625-7
references.pmid: 17882498
references.citation: Front Biosci (Landmark Ed). 2011;16:1733-45
references.pmid: 21196259
references.citation: Physiol Genomics. 2014 Mar 1;46(5):149-58
references.pmid: 24423970
references.citation: Arch Intern Med. 2000 Jan 10;160(1):53-60
references.pmid: 10632305
references.citation: Curr Hypertens Rep. 2010 Apr;12(2):135-42
references.pmid: 20424957
references.citation: J Hum Hypertens. 2005 Feb;19(2):149-54
references.pmid: 15361891
references.citation: Curr Pharm Des. 2010;16(6):609-18
references.pmid: 20388071
references.citation: Hypertension. 2010 Mar;55(3):652-9
references.pmid: 20142564
references.citation: Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4651-5
references.pmid: 1675786
references.citation: J Hypertens. 2013 Sep;31(9):1868-75
references.pmid: 23743809
references.citation: Am J Med. 1999 May;106(5):506-12
references.pmid: 10335721
references.citation: Hypertens Res. 2002 May;25(3):475-80
references.pmid: 12135329
references.citation: Age Ageing. 2010 Jan;39(1):92-8
references.pmid: 19933449
references.citation: Nurs Clin North Am. 2014 Jun;49(2):213-31
references.pmid: 24846469
references.citation: Hypertension. 2000 Nov;36(5):878-84
references.pmid: 11082160
references.citation: Med Care. 1999 Oct;37(10):994-1012
references.pmid: 10524367
references.citation: Am J Clin Nutr. 2012 Jun;95(6):1477-86
references.pmid: 22513296
references.citation: J Hypertens. 2015 Apr;33(4):727-35; discussion 735
references.pmid: 25915877
references.citation: Circulation. 2003 Nov 11;108(19):2317-22
references.pmid: 14568895
references.citation: J Hum Hypertens. 2015 Jun;29(6):394-5
references.pmid: 25391762
references.citation: J Gerontol A Biol Sci Med Sci. 2000 Nov;55(11):M667-71
references.pmid: 11078096
references.citation: Hypertension. 2015 Jul;66(1):183-9
references.pmid: 25941341
references.citation: Int J Cardiol. 2015 Apr 1;184:62-7
references.pmid: 25697872
references.citation: JAMA. 2007 Mar 21;297(11):1233-40
references.pmid: 17374817
references.citation: Neurobiol Aging. 2012 Apr;33(4):829.e21-8
references.pmid: 21855174
references.citation: Am J Clin Nutr. 2013 Nov;98(5):1263-71
references.pmid: 24047922
references.citation: Am J Kidney Dis. 2006 May;47(5):862-9
references.pmid: 16632026
references.citation: Lancet. 1999 Sep 18;354(9183):971-5
references.pmid: 10501357
references.citation: Ann N Y Acad Sci. 1996 Jun 15;786:1-11
references.pmid: 8687010
references.citation: Brain Behav Immun. 2004 Mar;18(2):114-9
references.pmid: 14986706
references.citation: Am J Public Health. 2010 Jan;100(1):100-7
references.pmid: 19910350
references.citation: Hypertension. 2001 Sep;38(3):399-403
references.pmid: 11566912
references.citation: BMJ. 2001 Jun 16;322(7300):1447-51
references.pmid: 11408299
references.citation: Arch Intern Med. 2012 Dec 10;172(22):1739-44
references.pmid: 23165923
references.citation: Age Ageing. 2010 Sep;39(5):592-7
references.pmid: 20650874
references.citation: Pharmacogenet Genomics. 2008 Aug;18(8):677-82
references.pmid: 18622260
references.citation: Mt Sinai J Med. 2003 Jan;70(1):3-22
references.pmid: 12516005
references.citation: J Gen Intern Med. 2014 Dec;29(12):1599-606
references.pmid: 25127725
references.citation: JAMA. 2003 Apr 2;289(13):1681-90
references.pmid: 12672737
references.citation: J Hypertens. 2001 Jul;19(7):1245-54
references.pmid: 11446714
references.citation: JAMA. 1995 Dec 20;274(23):1846-51
references.pmid: 7500533
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2413-8
references.pmid: 16214925
references.citation: Biomed Res Int. 2014;2014:406960
references.pmid: 25136585
references.citation: J Gerontol A Biol Sci Med Sci. 2009 Apr;64(4):455-61
references.pmid: 19196644
references.citation: BMC Geriatr. 2014;14:131
references.pmid: 25475854
references.citation: J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1251-61
references.pmid: 19723772
references.citation: Eur J Neurol. 2015 Apr;22(4):709-16
references.pmid: 25603760
references.citation: Curr Treat Options Neurol. 2015 Aug;17(8):367
references.pmid: 26094078
references.citation: Clin Sci (Lond). 2016 Jan;130(1):9-18
references.pmid: 26621877
references.citation: Hypertens Res. 2009 Sep;32(9):786-90
references.pmid: 19590507
references.citation: Arterioscler Thromb Vasc Biol. 1997 Jun;17(6):1121-7
references.pmid: 9194763
references.citation: Endocrine. 2014 Aug;46(3):397-405
references.pmid: 24504763
references.citation: Clin Geriatr Med. 2012 May;28(2):273-86
references.pmid: 22500543
references.citation: PLoS One. 2014;9(3):e92085
references.pmid: 24642982
references.citation: Int J Biochem Cell Biol. 2007;39(1):44-84
references.pmid: 16978905
references.citation: J Appl Physiol (1985). 2011 May;110(5):1160-70
references.pmid: 21183627
references.citation: PLoS One. 2013;8(10):e76984
references.pmid: 24116192
references.citation: Age (Dordr). 2011 Jun;33(2):167-83
references.pmid: 21153712