title: Serum uric acid is associated with non-dipping circadian pattern in young patients (30-40 years old) with newly diagnosed essential hypertension.
abstract: BACKGROUND
  We aimed at evaluating the relationship between the circadian blood pressure rhythm and UA level in young patients (30-40 years old) with newly diagnosed essential hypertension.
  
  
  METHODS
  The study included 62 essential hypertensive patients and 29 healthy controls (20 men, 35 ± 3 years) divided into two groups according to 24-hour ABPM results: 30 dippers and 32 nondippers.
  
  
  RESULTS
  Nondippers showed significantly higher both serum UA levels compared to dippers and controls (6.1 ± 0.7, 5.2 ± 0.9 and 4.1 ± 0.9 mg/dL, p < 0.001, respectively); and high sensitivity C-reactive protein (hsCRP) (4.1 ± 2.2 mg/L, 3.3 ± 1.9 mg/L, and 1.4 ± 0.9 mg/L, p < 0.001, respectively). After adjusting for age, sex, body mass index, smoking, creatinine levels, hsCRP and comorbidity, multivariate logistic regression analysis revealed an independent association between serum UA levels and nondipper pattern (OR 2.44, 95%CIs 1.4-4.1, p = 0.002).
  
  
  CONCLUSIONS
  Serum UA is independently associated with nondipper circadian pattern in young patients with newly diagnosed essential hypertension.
authors.affiliation: a Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation , "Federico II" University , Naples , Italy .
authors.forename: Francesco
authors.initials: F
authors.lastname: Giallauria
authors.affiliation: b Hypertenion Care Unit; "S. Giovanni di Dio e Ruggi d'Aragona" Hospital , Salerno , Italy .
authors.forename: Pasquale
authors.initials: P
authors.lastname: Predotti
authors.affiliation: c Division of Cardiology; "Casa di Cura Tortorella" , Salerno , Italy .
authors.forename: Antonio
authors.initials: A
authors.lastname: Casciello
authors.affiliation: a Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation , "Federico II" University , Naples , Italy .
authors.forename: Alessandra
authors.initials: A
authors.lastname: Grieco
authors.affiliation: a Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation , "Federico II" University , Naples , Italy .
authors.forename: Angelo
authors.initials: A
authors.lastname: Russo
authors.affiliation: b Hypertenion Care Unit; "S. Giovanni di Dio e Ruggi d'Aragona" Hospital , Salerno , Italy .
authors.forename: Anna
authors.initials: A
authors.lastname: Viggiano
authors.affiliation: b Hypertenion Care Unit; "S. Giovanni di Dio e Ruggi d'Aragona" Hospital , Salerno , Italy .
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Citro
authors.affiliation: b Hypertenion Care Unit; "S. Giovanni di Dio e Ruggi d'Aragona" Hospital , Salerno , Italy .
authors.forename: Amelia
authors.initials: A
authors.lastname: Ravera
authors.affiliation: d Critical Care Unit; "Ignazio Veris Delli Ponti" Hospital , Scorrano , Italy , and.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Ciardo
authors.affiliation: c Division of Cardiology; "Casa di Cura Tortorella" , Salerno , Italy .
authors.forename: Michele
authors.initials: M
authors.lastname: Guglielmi
authors.affiliation: e Department of Clinical and Experimental Medicine , Section of Geriatrics, University of Parma , Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Maggio
authors.affiliation: a Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation , "Federico II" University , Naples , Italy .
authors.forename: Carlo
authors.initials: C
authors.lastname: Vigorito
mesh_terms: D000328:Adult; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002097:C-Reactive Protein / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology*; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D012907:Smoking / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D002097:C-Reactive Protein
keywords: 24-hour ambulatory blood pressure monitoring; essential hypertension; high sensitivity C-reactive protein; nondipper circadian pattern; uric acid