title: Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study.
abstract: The aim of study is to determine whether chronic osteomyelitis (COM) is linked to an increased risk of head and neck cancer (HNC).We identify 17,033 patients with osteomyelitis and 68,125 subjects without osteomyelitis during 1996 to 2010 periods. Multivariable Cox proportional hazards regression analysis was used to measure the hazard ratio (HR) of head and neck cancer for the osteomyelitis cohort compared with the comparison cohort.A total of 99 patients in the COM and 228 patients in the comparison cohort developed HNC during an average 5.12 years of follow-up period. The incidence rate of HNC in the COM cohort was 1.51-fold (95% confidence interval [CI]: 1.17-1.95) higher than that in the comparison cohort after adjusting gender, age, urbanization level, monthly income, and comorbidities. In subgroup analysis, younger (less than 45 years-old) and patients without comorbidities have greater risks (adjusted HR: 2.29 [95% CI:1.43-3.66] and 1.74 [95% CI:1.28-2.38] respectively).This study results suggested the association between COM and HNC, particularly in younger population and patients without comorbidities.
authors.affiliation: From the Division of Infectious Disease, Department of Internal Medicine, China Medical University Hospital (C-TT, M-WH); Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University (C-TT, W-CS, C-HK); Management Office for Health Data, China Medical University Hospital (DL, H-JC, C-HM); School of Medicine, China Medical University (H-JC, C-HM); Department of Neurology, China Medical University Hospital (C-HT); School of Medicine, China Medical University College of Medicine, Taichung (C-HT); Department of Nuclear Medicine, E-Da Hospital, I-Shou University, Kaohsiung (M-CL); and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (C-HK).
authors.forename: Chia-Ta
authors.initials: CT
authors.lastname: Tsai
authors.forename: Mao-Wang
authors.initials: MW
authors.lastname: Ho
authors.forename: Dana
authors.initials: D
authors.lastname: Lin
authors.forename: Hsuan-Ju
authors.initials: HJ
authors.lastname: Chen
authors.forename: Chih-Hsin
authors.initials: CH
authors.lastname: Muo
authors.forename: Chun-Hung
authors.initials: CH
authors.lastname: Tseng
authors.forename: Wen-Chi
authors.initials: WC
authors.lastname: Su
authors.forename: Ming-Chia
authors.initials: MC
authors.lastname: Lin
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications*; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult
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