title: Detection of Critical Genes Associated with Overall Survival (OS) and Progression-Free Survival (PFS) in Reconstructed Canine B-Cell Lymphoma Gene Regulatory Network (GRN).
abstract: Canine B-cell lymphoma GRN was reconstructed from gene expression data in the STRING and MiMI databases. Critical genes of networks were identified and correlations of critical genes with overall survival (OS) and progression-free survival (PFS) were evaluated. Significant changes were detected in the expressions of GLUL, CD44, CD79A, ARF3, FOS, BLOC1S1, FYN, GZMB, GALNT3, IFI44, CD3G, GNG2, ESRP1, and CCND1 in the STRING network and of PECAM1, GLUL, CD44, GDI1, E2F4, TLE1, CD79A, UCP2, CCND1, FYN, RHOQ, BIN1, and A2M in the MiMI network. Final survival analysis highlighted CCND1 and FOS as genes with significant correlations with OS and PFS.
authors.affiliation: a Faculty of Veterinary Medicine, Department of Clinical Science, Shahid Bahonar University of Kerman , Kerman , Iran.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Zamani-Ahmadmahmudi
authors.affiliation: b Molecular Biology Research Center, Baqiyatallah University of Medical Sciences , Tehran , Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Najafi
authors.affiliation: c Faculty of Veterinary Medicine, Department of Clinical Pathology, University of Tehran , Tehran , Iran.
authors.forename: Seyed Mahdi
authors.initials: SM
authors.lastname: Nassiri
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics; D030541:Databases, Genetic; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000235:genetics* / Q000401:mortality; D004285:Dogs; D020869:Gene Expression Profiling / Q000379:methods / Q000662:veterinary; D016762:Genes, fos; D020022:Genetic Predisposition to Disease; D053208:Kaplan-Meier Estimate; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000401:mortality / Q000662:veterinary*; D020411:Oligonucleotide Array Sequence Analysis / Q000662:veterinary; D010641:Phenotype; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D019938:Cyclin D1
keywords: Canine lymphoma; Critical genes; Gene regulatory network (GRN); Overall survival (OS); Progression-free survival (PFS)