title: DNA methyltransferase 3a rs1550117 genetic polymorphism predicts poor survival in gastric cancer patients.
abstract: DNA methyltransferase 3a (DNMT3a) have been suggested to play a crucial role in human cancer prognosis. Single nucleotide polymorphisms (SNPs) in DNMT3a genes may have an impact on the prognosis of cancers. This study aimed to investigate the association between SNPs of DNMT3a gene and prognosis of gastric cancer (GC). Two sites of DNMT3a SNPs, rs1550117 and rs13420827 were selected and genotyped using TaqMan assay in 447 GC patients who received gastrectomy. Effects of genotypes on clinical outcomes of GC were calculated by Kaplan-Meier survival analysis and Cox regression model. We found that the AG or AA genotype of rs1550117 was associated with significantly poorer survival and increased death risk of GC compared with GG genotype (dominant model: HR=1.35, 95% CI=1.01-1.80, P=0.043). Further multivariate Cox regression analysis revealed that in addition to the known factors including male, larger tumor sizes and high clinical stage, rs1550117 variant was an independently predictive factor for survival in GC patients. No significant association was found between rs13420827 genetic variants and GC prognosis. Our findings first demonstrated that DNMT3a rs1550117 polymorphism may be a potential biomarker in predicting overall survival of GC patients.
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Division of Pathology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Hongxi
authors.initials: H
authors.lastname: Ma
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Donghui
authors.initials: D
authors.lastname: Cao
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Wu
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Simin
authors.initials: S
authors.lastname: Wen
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Lili
authors.initials: L
authors.lastname: You
authors.affiliation: Department of Gastric and Colorectal Surgery, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Cao
authors.affiliation: Division of Clinical Epidemiology, First Hospital of Jilin University Changchun 130021, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D000090205:DNA Methyltransferase 3A; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality
chemical_list: C000717967:DNMT3A protein, human; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A
keywords: DNA methyltransferase 3a; gastric cancer; overall survival; polymorphisms
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