title: Continuous Positive Airway Pressure for Upper Airway Obstruction in Infants with Pierre Robin Sequence.
abstract: The aim of the study was to evaluate noninvasive continuous positive airway pressure as first-line treatment for upper airway obstruction in neonates with Pierre Robin sequence. Forty-four neonates were enrolled and classified in 4 groups: ventilator-dependent patients (severe upper airway obstruction group), patients with clinical upper airway obstruction, an abnormal (moderate upper airway obstruction group) or normal polygraphy (mild upper airway obstruction group), and those with no clinical upper airway obstruction (no upper airway obstruction group). Five neonates in the severe upper airway obstruction group (n = 9) were successfully managed by noninvasive continuous positive airway pressure and 4 required a tracheotomy. The moderate upper airway obstruction group (n = 4) was successfully managed by noninvasive continuous positive airway pressure and the other patients by prone positioning. Continuous positive airway pressure represents an effective treatment of upper airway obstruction in Pierre Robin sequence and may be recommended in selected patients.
  
  
  METHODS
  Therapeutic, IV.
authors.affiliation: Paris, France From the Pediatric Noninvasive Ventilation and Sleep Unit, General Pediatric Department, National Reference Center for Pierre Robin Sequence, Pediatric Plastic and Maxillofacial Surgery Department, Neonatology Department, and Pediatric Head and Neck Surgery Department, AP-HP, Hôpital Necker-Enfants Malades; and Paris Descartes University.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Amaddeo
authors.forename: Veronique
authors.initials: V
authors.lastname: Abadie
authors.forename: Christel
authors.initials: C
authors.lastname: Chalouhi
authors.forename: Natacha
authors.initials: N
authors.lastname: Kadlub
authors.forename: Annick
authors.initials: A
authors.lastname: Frapin
authors.forename: Alexandre
authors.initials: A
authors.lastname: Lapillonne
authors.forename: Nicolas
authors.initials: N
authors.lastname: Leboulanger
authors.forename: Erea Noel
authors.initials: EN
authors.lastname: Garabédian
authors.forename: Arnaud
authors.initials: A
authors.lastname: Picard
authors.forename: Brigitte
authors.initials: B
authors.lastname: Fauroux
mesh_terms: D000402:Airway Obstruction / Q000209:etiology* / Q000628:therapy*; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010855:Pierre Robin Syndrome / Q000150:complications*
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