title: A 33-year-old male patient with paternal derived duplication of 14q11.2-14q22.1~22.3: clinical course, phenotypic and genotypic findings.
abstract: We report on a 33-year-old patient with mosaic interstitial duplication on chromosome 14q11.2-14q22.1~22.3 with severe physical and mental retardation and multiple dysmorphisms. This patient was admitted to our pediatric hospital due to severe dehydration and malnutrition as a result of food refusal. It is an actual phenomenon that patients with severe inborn clinical problems nowadays survive due to progress and care of modern medicine. Nevertheless, transition from pediatric care to adult medicine seems to remain a challenging problem. We demonstrate the clinical course as well as clinical and genetic findings of this adult patient. Comparisons are made to previously reported cases with mosaic trisomy 14 involving a proximal interstitial duplication on the long arm of chromosome 14.
authors.forename: Bardo
authors.initials: B
authors.lastname: Wannenmacher
authors.forename: Diana
authors.initials: D
authors.lastname: Mitter
authors.forename: Franziska
authors.initials: F
authors.lastname: Kießling
authors.forename: Thomas
authors.initials: T
authors.lastname: Liehr
authors.forename: Anja
authors.initials: A
authors.lastname: Weise
authors.forename: Manuela
authors.initials: M
authors.lastname: Siekmeyer
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics* / Q000473:pathology; D000328:Adult; D002648:Child; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D020440:Gene Duplication / Q000235:genetics*; D005838:Genotype; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008607:Intellectual Disability / Q000235:genetics* / Q000473:pathology; D008297:Male; D009030:Mosaicism; D010641:Phenotype; D011379:Prognosis; D014314:Trisomy / Q000235:genetics*; D055815:Young Adult