title: Angelica sinensis reduced Aβ-induced memory impairment in rats.
abstract: BACKGROUND
  Studies have shown that Angelica sinensis (JiLin AoDong Medicine Industry Groups Co., Ltd., Jilin, China) root (AS) ameliorates various diseases, although its effects in Alzheimer's disease (AD) have not been elucidated.
  
  
  OBJECTIVE
  The present study examined the effects of AS in a rat model of AD.
  
  
  METHODS
  Positional Aβ injections were administered to rats. The behavioral effects of AS administration were examined using the Morris water maze, and the molecular effects on gene and protein expression, and apoptosis, were determined.
  
  
  RESULTS
  AS reversed the social behavioral impairments observed in this rat model of Aβ-induced memory impairment. Western blot analysis also revealed lower hippocampal levels of Aβ and β-site amyloid precursor protein-cleaving enzyme. Terminal deoxynucleotidyl transferased UTP nick end labeling indicated that AS significantly inhibited apoptosis via effects on nuclear factor kappa B (NF-κB) signaling. Real-time PCR, enzyme-linked immunosorbent assay, and immunohistochemical staining indicated that AS effectively inhibited inflammation and upregulated expression of glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) in the hippocampus of this rat AD model.
  
  
  CONCLUSIONS
  AS effectively rescued the symptoms of AD in a rat model by inhibiting inflammation, apoptosis, and NF-κB signaling pathway.
  
  
  CONCLUSIONS
  These findings suggested that AS could provide a potential drug for the treatment of AD.
authors.affiliation: a Changchun University of Chinese Medicine , Changchun , China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Duan
authors.affiliation: a Changchun University of Chinese Medicine , Changchun , China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Wang
authors.affiliation: a Changchun University of Chinese Medicine , Changchun , China.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Jiang
authors.affiliation: a Changchun University of Chinese Medicine , Changchun , China.
authors.forename: Ying-Yuan
authors.initials: YY
authors.lastname: Pei
authors.affiliation: a Changchun University of Chinese Medicine , Changchun , China.
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Guan
authors.affiliation: a Changchun University of Chinese Medicine , Changchun , China.
authors.forename: Zhi-Dong
authors.initials: ZD
authors.lastname: Qiu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000378:metabolism*; D029971:Angelica sinensis; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D017208:Rats, Wistar
chemical_list: D016229:Amyloid beta-Peptides; D004365:Drugs, Chinese Herbal; C044613:angelicae sinensis extract; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509281:Bace1 protein, rat
keywords: Alzheimer's disease; apoptosis; inflammation; nuclear factor kappa B signaling pathway; radix Angelica sinensis