title: Analgesic and CNS Depressant Activities of Sea Anemone Heteractis aurora Nematocyst Toxin.
abstract: Marine organisms are the excellent sources for biologically active compounds. Cnidarian venoms are potentially valuable materials used for biomedical research and drug development. The present work was carried out to analyse haemolytic, analgesic and CNS depressant activity of sea anemone Heteractis aurora. In haemolytic assay, among the five different RBC blood cells, the chicken blood exhibited maximum hemolytic activity of 64 Hemolytic Unit (HU). The maximum Analgesic Ratio (AR) of 5 recorded at 15 and 30 min interval and minimum was recorded after 45, 60 and 120 min time intervals. In jumping response activity, the maximum of 5 AR recorded at 15, 30 & 45 min and minimum was recorded at 90 & 120 min time intervals. The maximum decrease of depressant activity of 45.07% was determined in CNS depressant activity. Anti-inflammatory activity showed significant inhibition by crude extract of Heteractis aurora.
authors.forename: Sengapillai
authors.initials: S
authors.lastname: Thangaraj
authors.affiliation: Marine Biotoxinology Lab. Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai - 608 502, Tamil Nadu, India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Bragadeeswaran
authors.forename: Natarajah
authors.initials: N
authors.lastname: Srikumaran
authors.forename: Anbukkarasu
authors.initials: A
authors.lastname: Suguna
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002417:Cattle; D002492:Central Nervous System Depressants / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002645:Chickens; D003064:Cnidarian Venoms / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy / Q000378:metabolism; D006041:Goats; D006461:Hemolysis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D051379:Mice; D058894:Nematocyst; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D012615:Sea Anemones
chemical_list: D000700:Analgesics; D002492:Central Nervous System Depressants; D003064:Cnidarian Venoms