title: Quinoline biodegradation by filamentous fungus Cunninghamella elegans and adaptive modifications of the fungal membrane composition.
abstract: Quinoline, which belongs to N-heterocyclic compounds, occurs naturally in the environment and is used in numerous industrial processes. The structures of various chemicals, such as dyes and medicines, are based on this compound. Due to that fact, quinoline and its derivatives are widely distributed in environment and can exert toxic effects on organisms from different trophic levels. The ability of the filamentous fungus Cunninghamella elegans IM 1785/21Gp to degrade quinoline and modulate the membrane composition in response to the pollutant was studied. C. elegans IM 1785/21Gp removes quinoline with high efficiency and transforms the pollutant into two novel hydroxylated derivatives, 2-hydroxyquinoline and 3-hydroxyquinoline. Moreover, due to the disruption in the membrane stability by quinoline, C. elegans IM 1785/21Gp modulates the fatty acid composition and phospholipid profile.
authors.affiliation: Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237, Lodz, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Felczak
authors.affiliation: Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237, Lodz, Poland.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Bernat
authors.affiliation: Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237, Lodz, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Różalska
authors.affiliation: Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237, Lodz, Poland. katalis@biol.uni.lodz.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Lisowska
mesh_terms: D001673:Biodegradation, Environmental; D004396:Coloring Agents / Q000378:metabolism; D020093:Cunninghamella / Q000378:metabolism / Q000502:physiology*; D004785:Environmental Pollutants / Q000378:metabolism*; D006900:Hydroxylation; D006912:Hydroxyquinolines / Q000378:metabolism; D011804:Quinolines / Q000378:metabolism*
chemical_list: D004396:Coloring Agents; D004785:Environmental Pollutants; D006912:Hydroxyquinolines; D011804:Quinolines; C107724:2-hydroxyquinoline; C037219:quinoline
keywords: Degradation; Fungi; Phospholipid profile; Quinoline
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