title: Meta-analysis of the differentially expressed microRNA profiles in nasopharyngeal carcinoma.
abstract: MicroRNAs(miRNAs), as non-coding molecules, were proved to be correlated with gene expression in naspharyngeal carcinoma (NPC) development. In this research, a comprehensive meta-analysis of eight independent miRNA expression studies in NPC was preformed by using robust rank aggregation method (RRA), which contained a total of 775 tumor and 227 non-cancerous samples. There were 7 significant dysregulated miRNAs identified including three increased (miR-483-5p, miR-29c-3p and miR-205-5p) and four decreased (miR-29b-3p, let-7d-5p, miR-100- 5p and let-7g-5p) miRNAs. Subsequently, the miRNA target prediction and pathway enrichment analysis were carried out to find out the biological and functional relevant genes involved in the meta-signature miRNA regulation. Finally, several signaling and cancer pathogenesis pathways were suggested to be more frequently associated with the progression of NPC. In this research the meta-signature miRNA identified may be used to develop a series of diagnostic and prognostic biomarkers for NPC that serve specificity for use in clinics.
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
authors.forename: Junwen
authors.initials: J
authors.lastname: Luan
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
authors.forename: Junfu
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
authors.forename: Qinghong
authors.initials: Q
authors.lastname: Su
authors.affiliation: Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, Shandong 250033, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Jiang
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Xu
mesh_terms: D002277:Carcinoma; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D053263:Gene Regulatory Networks / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs
keywords: meta-analysis; miRNA; nasopharyngeal carcinoma; profiling; roubust rank aggregation method
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