title: [DRUG-INDUCED LIVER DISEASE IN MULTICOMPONENT THERAPY OF COMORBID CONDITIONS].
abstract: The problem of drug liver lesions is of particular relevance in our time, when the application of medical standards in different disease groups includes 8-12 medicines in case of simultaneous reception (polypharmacy), which may cause the development of different forms drug-induced hepatotoxic reactions in 28% of cases. For diagnosis it is necessary to consider the baseline characteristics of the patient, the properties of drugs, duration and dose of administration. There are international criteria for the evaluation of medicinal liver lesions, including the time interval for the reaction after drug withdrawal, exclusion of alternative causes of liver damage and a positive response to repeated administration of the drug. It is mandatory for differential diagnosis to exclude other forms of liver damage viral and non-viral etiology. Thought the purpose of each drug, and in the case of drug liver damage--adequate and timely recruitment hepatoprotective therapy based on the molecular mechanisms of pathogenesis will not only contribute to the reduction of risk factors hepatotoxic manifestations, but also the possibility to conduct a complete comprehensive treatment of the underlying pathological process.
authors.forename: S N
authors.initials: SN
authors.lastname: Mehtiyev
authors.forename: E N
authors.initials: EN
authors.lastname: Zinovieva
authors.forename: O A
authors.initials: OA
authors.lastname: Mehtiyev
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans