title: From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia.
abstract: Oxidative stress might contribute to the occurrence of cancers, including the hematological ones. Various genetic polymorphisms were shown to increase the quantity of reactive oxygen species, a phenomenon that is able to induce mutations and thus promote cancers. The purpose of the study was to evaluate the association between CAT C262T, GPX1 Pro198Leu, MnSOD Ala16Val, GSTM1, GSTT1, and GSTP1 Ile105Val gene polymorphisms and acute myeloid leukemia risk, in a case-control study comprising 102 patients and 303 controls. No association was observed between AML and variant genotypes of CAT, MnSOD, GSTM1, and GSTT1 polymorphisms. Our data revealed a statistically significant difference regarding the frequencies of GPX1 Pro198Leu and GSTP1 Ile105Val variant genotypes between AML patients and controls (p < 0.001). Our results showed no association in the distribution of any of the CAT C262T, GPX1 Pro198Leu, GSTM1, GSTT1, and GSTP1 polymorphisms regarding age, gender, FAB subtype, cytogenetic risk groups, FLT3 and DNMT3 gene mutations, and overall survival. Our data suggests that the presence of variant allele and genotype of GPX1 Pro198Leu and GSTP1 Ile105Val gene polymorphisms may modulate the risk of developing AML.
authors.affiliation: Department of Medical Genetics, University of Medicine and Pharmacy Targu Mures, 38 Gh Marinescu Street, 540139 Targu Mures, Romania.
authors.forename: Claudia
authors.initials: C
authors.lastname: Bănescu
authors.affiliation: Department of Medical Informatics and Biostatistics, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Iancu
authors.affiliation: Department of Medical Genetics, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
authors.forename: Adrian P
authors.initials: AP
authors.lastname: Trifa
authors.affiliation: Hematology Clinic 1, University of Medicine and Pharmacy Targu Mures, 38 Gh Marinescu Street, 540139 Targu Mures, Romania.
authors.forename: Marcela
authors.initials: M
authors.lastname: Cândea
authors.affiliation: Hematology Clinic 2, University of Medicine and Pharmacy Targu Mures, 38 Gh Marinescu Street, 540139 Targu Mures, Romania.
authors.forename: Erzsebet
authors.initials: E
authors.lastname: Benedek Lazar
authors.affiliation: Department of Medical Genetics, University of Medicine and Pharmacy Targu Mures, 38 Gh Marinescu Street, 540139 Targu Mures, Romania.
authors.forename: Valeriu G
authors.initials: VG
authors.lastname: Moldovan
authors.affiliation: Pediatric Clinic, University of Medicine and Pharmacy Targu Mures, 38 Gh Marinescu Street, 540139 Targu Mures, Romania.
authors.forename: Carmen
authors.identifier: 0000-0002-8056-1339
authors.initials: C
authors.lastname: Duicu
authors.affiliation: Department of Medical Genetics, University of Medicine and Pharmacy Targu Mures, 38 Gh Marinescu Street, 540139 Targu Mures, Romania.
authors.forename: Florin
authors.identifier: 0000-0002-4297-9988
authors.initials: F
authors.lastname: Tripon
authors.affiliation: Department of Medical Genetics, University of Medicine and Pharmacy Targu Mures, 38 Gh Marinescu Street, 540139 Targu Mures, Romania.
authors.forename: Andrei
authors.initials: A
authors.lastname: Crauciuc
authors.affiliation: Department of Laboratory Medicine, University of Medicine and Pharmacy Targu Mures, 38 Gh Marinescu Street, 540139 Targu Mures, Romania.
authors.forename: Minodora
authors.initials: M
authors.lastname: Dobreanu
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D005838:Genotype; D005979:Glutathione Peroxidase / Q000235:genetics*; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007532:Isoleucine / Q000737:chemistry; D007930:Leucine / Q000737:chemistry; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D011110:Polymorphism, Genetic; D011392:Proline / Q000737:chemistry; D017382:Reactive Oxygen Species; D012306:Risk; D012383:Romania; D013482:Superoxide Dismutase / Q000235:genetics; D014633:Valine / Q000737:chemistry; D000094765:Glutathione Peroxidase GPX1
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D007532:Isoleucine; D011392:Proline; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D007930:Leucine; D014633:Valine; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human
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