title: Short-term effects of splenectomy on serum fibrosis indexes in liver cirrhosis patients.
abstract: OBJECTIVE
  To determine the changing patterns of 4 liver fibrosis markers pre and post splenectomy (combined with pericardial devascularization [PCDV]) and to examine the short-term effects of splenectomy on liver fibrosis.
  
  
  METHODS
  Four liver fibrosis markers of 39 liver cirrhosis patients were examined pre, immediately post, 2 days post, and 1 week post (15 cases) splenectomy (combined with PCDV).
  
  
  RESULTS
  The laminin (LN) level decreased immediately post surgery compared with the preoperative LN level (P < 0.05). The type IV collagen level decreased immediately post surgery compared with that pre surgery (P < 0.05), it significantly increased (P < 0.05) 2 days post surgery and significantly decreased 1 week post surgery (P < 0.05). Hyaluronic acid and the procollagen III N-terminal peptide levels increased significantly 2 days post surgery compared with that pre and immediately post surgery, they significantly decreased 1 week post surgery compared to 2 days post surgery (P < 0.05).
  
  
  CONCLUSIONS
  In the short-term, the 4 liver fibrosis markers and the FibroScans post splenectomy showed characteristic changes, splenectomy may transiently initiate the degradation process of liver fibrosis.
authors.affiliation: Department of General Surgery, Capital Medical University Affiliated Beijing Youan Hospital Beijing 100069, China.
authors.forename: Degang
authors.initials: D
authors.lastname: Kong
authors.affiliation: The Fifth Hospital of Shijiazhuang Shijiazhuang, China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute & Hospital of Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital Beijing 100853, China.
authors.forename: Shichun
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of General Surgery, Capital Medical University Affiliated Beijing Youan Hospital Beijing 100069, China.
authors.forename: Qingliang
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of General Surgery, Capital Medical University Affiliated Beijing Youan Hospital Beijing 100069, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lai
authors.affiliation: Department of General Surgery, Capital Medical University Affiliated Beijing Youan Hospital Beijing 100069, China.
authors.forename: Jushan
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of General Surgery, Capital Medical University Affiliated Beijing Youan Hospital Beijing 100069, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Lin
authors.affiliation: Department of General Surgery, Capital Medical University Affiliated Beijing Youan Hospital Beijing 100069, China.
authors.forename: Daobing
authors.initials: D
authors.lastname: Zeng
authors.affiliation: Department of General Surgery, Capital Medical University Affiliated Beijing Youan Hospital Beijing 100069, China.
authors.forename: Binwei
authors.initials: B
authors.lastname: Duan
authors.affiliation: Department of General Surgery, Capital Medical University Affiliated Beijing Youan Hospital Beijing 100069, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of General Surgery, Capital Medical University Affiliated Beijing Youan Hospital Beijing 100069, China.
authors.forename: Jilei
authors.initials: J
authors.lastname: Cao
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D024141:Collagen Type IV / Q000097:blood*; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D007797:Laminin / Q000097:blood*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011347:Procollagen / Q000097:blood*; D013156:Splenectomy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D024141:Collagen Type IV; D007797:Laminin; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D006820:Hyaluronic Acid
keywords: 4 liver fibrosis markers; Splenectomy; liver cirrhosis
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