title: Resistance to thyroid hormone α, revelation of basic study to clinical consequences.
abstract: In the past 3 years, 15 patients with resistance to thyroid hormone α (RTHα), nine THRA gene mutations have been reported, reforming classification of RTH. RTHα exhibits distinguished clinical manifestations from RTHβ, including growth retardation, skeletal dysplasia, impaired neurodevelopment, cardiovascular dysfunction, constipation and specific thyroid axis type. This review focuses on possible pathogenesis by revelatory basic science of RTHα animal models in vivo, and patients' mutant thyroid hormone receptor α (TRα) in vitro. Clinical manifestations and L-T4 effects are summarized, showing strong correlation to the severity of mutation mostly within the domain which dominated TR interaction with T3 and its corepressors/coactivators. In particular, we propose the diagnosis clues and promising treatment for clinicians.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Tang
authors.forename: Miao
authors.initials: M
authors.lastname: Yu
authors.forename: Xiaolan
authors.identifier: http://orcid.org/0000-0001-5369-9466
authors.initials: X
authors.lastname: Lian
mesh_terms: D006801:Humans; D010641:Phenotype; D037021:Thyroid Hormone Receptors alpha / Q000378:metabolism*; D018382:Thyroid Hormone Resistance Syndrome / Q000175:diagnosis* / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D037021:Thyroid Hormone Receptors alpha; D013963:Thyroid Hormones