title: [Basophilic granulocytes and autoimmune diseases. Can basophilic granulocytes modulate B-cell functions in systemic lupus erythematosus?].
abstract: BACKGROUND
  B-cells play an important role in the pathogenesis of systemic lupus erythematosus (SLE); however, many other cell types are also involved in disease development. In a murine lupus model it was demonstrated that basophils are indispensable for the development of lupus symptoms.
  
  
  OBJECTIVE
  This study investigated whether there is evidence for a relevant interaction between B-cells and basophils under physiological and pathological conditions.
  
  
  METHODS
  A selective review of the literature was performed and some preliminary data about the interaction of basophils and B-cells are reported in this article. For the experiments, isolated B-cells were cultured in vitro in the presence or absence of basophils and B-cell survival, proliferation, plasma cell development and antibody production were determined.
  
  
  RESULTS
  Data from the literature show that there is evidence for an interaction between basophils and B-cells in a murine model. Our investigations confirmed that human basophils also support the survival and proliferation of B-cells. Furthermore, plasma cell differentiation and antibody production, most importantly IgG secretion, are enhanced. First experimental ex vivo analyses of basophils from SLE patients demonstrate that these cells exhibit a higher activation level compared to basophils from healthy controls.
  
  
  CONCLUSIONS
  In summary, previously published data and our own data demonstrate that there is an interaction between human basophils and B-cells. A better understanding of the role of basophils in the pathogenesis of SLE could lead to the development of new therapeutic strategies.
authors.affiliation: Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, OE6710, 30625, Hannover, Deutschland. Meyer-Bahlburg.Almut@mh-hannover.de.
authors.forename: A
authors.initials: A
authors.lastname: Meyer-Bahlburg
authors.affiliation: Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, OE6710, 30625, Hannover, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Dijkstra
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D001491:Basophils / Q000276:immunology* / Q000473:pathology; D002450:Cell Communication / Q000276:immunology*; D019317:Evidence-Based Medicine; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000473:pathology; D051379:Mice; D018448:Models, Immunological
keywords: Antibodies; B cells; Basophils; Plasma cells; SLE
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