title: Posterior Segment Drug Delivery Devices: Current and Novel Therapies in Development.
abstract: Ocular drug delivery by conventional routes of administration does not maintain therapeutic drug concentrations in the target tissues for a long duration because of various anatomical and physiological barriers. Treatment of diseases of the posterior segment of the eye requires novel drug delivery systems that can overcome these barriers for efficacious delivery, provide controlled release for the treatment of chronic diseases, and increase patient's and doctor's convenience to reduce the dosing frequency and associated side effects. Thereby, an increasing number of sustained-release drug delivery devices using different mechanisms have been developed. This article discusses various current and future sustained-release drug delivery systems for the posterior segment disorders.
authors.affiliation: 1 Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Pooja
authors.initials: P
authors.lastname: Bansal
authors.affiliation: 2 Department of Ophthalmology, Vision Eye Centre , Siri Fort Road, New Delhi, India .
authors.forename: Satpal
authors.initials: S
authors.lastname: Garg
authors.affiliation: 1 Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Yograj
authors.initials: Y
authors.lastname: Sharma
authors.affiliation: 1 Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Pradeep
authors.initials: P
authors.lastname: Venkatesh
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods*; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D057972:Posterior Eye Segment