title: Potential benefits of physical activity during pregnancy for the reduction of gestational diabetes prevalence and oxidative stress.
abstract: Changes in quality of nutrition, habits, and physical activity in modern societies increase susceptibility to obesity, which can deleteriously affect pregnancy outcome. In particular, a sedentary lifestyle causes dysfunction in blood flow, which impacts the cardiovascular function of pregnant women. The main molecular mechanism responsible for this effect is the synthesis and bioavailability of nitric oxide, a phenomenon regulated by the antioxidant capacity of endothelial cells. These alterations affect the vascular health of the mother and vascular performance of the placenta, the key organ responsible for the healthy development of the fetus. In addition to the increases in systemic vascular resistance in the mother, placental oxidative stress also affects the feto-placental blood flow. These changes can be integrated into the proteomics and metabolomics of newborns.
authors.affiliation: Department of Obstetrics & Childcare, Faculty of Biological Sciences, Universidad de Concepción, P.O. Box 160-C, Concepción 4070386, Chile. Electronic address: marcecid@udec.cl.
authors.forename: Marcela
authors.initials: M
authors.lastname: Cid
authors.affiliation: Vascular Physiology Laboratory, Department of Physiology, Faculty of Biological Sciences, University of Concepción, P.O. Box 160-C, Concepción 4070386, Chile; Group of Research and Innovation in Vascular Health (GRIVAS-Health), Chillán, Chile. Electronic address: mgonzalezo@udec.cl.
authors.forename: Marcelo
authors.initials: M
authors.lastname: González
mesh_terms: D016640:Diabetes, Gestational / Q000378:metabolism / Q000517:prevention & control*; D015444:Exercise; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D018384:Oxidative Stress; D011247:Pregnancy