title: Implications of direct-to-consumer whole-exome sequencing in South Africa.
abstract: This editorial examines a number of vitally important ethical, legal and scientific concerns that have to be addressed to ensure proper and ethical implementation of direct-to-consumer whole-exome sequencing in South Africa. Individuals taking part in this endeavour must be fully informed of the positive and negative sequelae.
authors.affiliation: Southern African Society for Human Genetics, Johannesburg, South Africa; Division of Human Genetics, School of Pathology, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa. zane.lombard@wits.ac.za.
authors.forename: Zané
authors.initials: Z
authors.lastname: Lombard
authors.forename: Fiona
authors.initials: F
authors.lastname: Baine
authors.forename: Amanda
authors.initials: A
authors.lastname: Krause
authors.forename: Anneline
authors.initials: A
authors.lastname: Lochan
authors.forename: Shelley
authors.initials: S
authors.lastname: Macualay
authors.forename: Careni
authors.initials: C
authors.lastname: Spencer
authors.forename: Colleen
authors.initials: C
authors.lastname: Aldous
authors.forename: Jantina
authors.initials: J
authors.lastname: De Vries
authors.forename: Karen
authors.initials: K
authors.lastname: Fieggen
authors.forename: Bertram
authors.initials: B
authors.lastname: Henderson
authors.forename: Eileen
authors.initials: E
authors.lastname: Hoal
authors.forename: Craig
authors.initials: C
authors.lastname: Kinnear
authors.forename: Noelene
authors.initials: N
authors.lastname: Kinsley
authors.forename: Alison
authors.initials: A
authors.lastname: September
authors.forename: Michael
authors.initials: M
authors.lastname: Urban
authors.forename: Himla
authors.initials: H
authors.lastname: Soodyall
authors.forename: Michael
authors.initials: M
authors.lastname: Pepper
authors.forename: Michele
authors.initials: M
authors.lastname: Ramsay
mesh_terms: D005817:Genetic Counseling / Q000458:organization & administration*; D030661:Genetic Privacy / Q000941:ethics / Q000331:legislation & jurisprudence; D055106:Genome-Wide Association Study / Q000379:methods / Q000639:trends; D006801:Humans; D017422:Sequence Analysis, DNA / Q000941:ethics / Q000639:trends; D013019:South Africa