title: Deciphering Parameter Sensitivity in the BvgAS Signal Transduction.
abstract: To understand the switching of different phenotypic phases of Bordetella pertussis, we propose an optimized mathematical framework for signal transduction through BvgAS two-component system. The response of the network output to the sensory input has been demonstrated in steady state. An analysis in terms of local sensitivity amplification characterizes the nature of the molecular switch. The sensitivity analysis of the model parameters within the framework of various correlation coefficients helps to decipher the contribution of the modular structure in signal propagation. Once classified, the model parameters are tuned to generate the behavior of some novel strains using simulated annealing, a stochastic optimization technique.
authors.affiliation: Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah 711103, India.
authors.forename: Tarunendu
authors.initials: T
authors.lastname: Mapder
authors.affiliation: Department of Chemistry, University of Calcutta, 92 A P C Road, Kolkata 700 009, India.
authors.forename: Srijeeta
authors.initials: S
authors.lastname: Talukder
authors.affiliation: Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah 711103, India.
authors.forename: Sudip
authors.initials: S
authors.lastname: Chattopadhyay
authors.affiliation: Department of Chemistry, Bose Institute, 93/1 A P C Road, Kolkata 700 009, India.
authors.forename: Suman K
authors.initials: SK
authors.lastname: Banik
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001886:Bordetella pertussis / Q000235:genetics / Q000378:metabolism*; D008962:Models, Theoretical; D009876:Operon / Q000235:genetics; D010766:Phosphorylation; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins
references.citation: Proc Natl Acad Sci U S A. 1981 Nov;78(11):6840-4
references.pmid: 6947258
references.citation: Trends Microbiol. 2003 Aug;11(8):367-73
references.pmid: 12915094
references.citation: Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):691-6
references.pmid: 12522261
references.citation: Annu Rev Genet. 2007;41:121-45
references.pmid: 18076326
references.citation: Curr Opin Microbiol. 2000 Apr;3(2):165-70
references.pmid: 10745001
references.citation: Genes Dev. 2008 Oct 1;22(19):2601-11
references.pmid: 18832064
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12063-8
references.pmid: 17615238
references.citation: J Chem Phys. 2014 Mar 28;140(12):125101
references.pmid: 24697480
references.citation: Mol Microbiol. 2003 Apr;48(1):25-51
references.pmid: 12657043
references.citation: Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17457-62
references.pmid: 18987315
references.citation: Mol Microbiol. 2005 Nov;58(3):700-13
references.pmid: 16238621
references.citation: BMC Genomics. 2011;12:207
references.pmid: 21524285
references.citation: Phys Biol. 2010;7(3):036005
references.pmid: 20733247
references.citation: Annu Rev Biochem. 2000;69:183-215
references.pmid: 10966457
references.citation: EMBO J. 1991 Dec;10(12):3971-5
references.pmid: 1718746
references.citation: PLoS One. 2008;3(3):e1771
references.pmid: 18335046
references.citation: Mol Biosyst. 2010 Mar;6(3):531-42
references.pmid: 20174681
references.citation: Proc Natl Acad Sci U S A. 1990 May;87(10):3763-7
references.pmid: 2111016
references.citation: Biosystems. 2012 Nov;110(2):107-18
references.pmid: 22960292
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19931-5
references.pmid: 18077424
references.citation: Science. 1983 May 13;220(4598):671-80
references.pmid: 17813860
references.citation: Proc Natl Acad Sci U S A. 1990 Dec;87(24):10067
references.pmid: 2263607
references.citation: Mol Biosyst. 2013 Nov;9(11):2635-44
references.pmid: 24056999
references.citation: J Bacteriol. 1997 Mar;179(5):1755-63
references.pmid: 9045838
references.citation: Mol Microbiol. 2008 Jun;68(5):1196-215
references.pmid: 18363790
references.citation: Mol Biosyst. 2014 Jul 29;10(9):2338-46
references.pmid: 24955938
references.citation: J Chem Phys. 2011 Oct 28;135(16):165103
references.pmid: 22047268
references.citation: J R Soc Interface. 2011 Apr 6;8(57):480-8
references.pmid: 20702449
references.citation: Nat Rev Microbiol. 2014 Apr;12(4):274-88
references.pmid: 24608338
references.citation: Cell. 1996 Sep 20;86(6):845-8
references.pmid: 8808618
references.citation: Science. 1982 Jul 16;217(4556):220-5
references.pmid: 7089556
references.citation: Phys Biol. 2009;6(4):046008
references.pmid: 19843985
references.citation: Chem Rev. 2005 Jul;105(7):2811-28
references.pmid: 16011325
references.citation: Adv Exp Med Biol. 2008;631:149-60
references.pmid: 18792687
references.citation: J Theor Biol. 2008 Sep 7;254(1):178-96
references.pmid: 18572196