title: Polymorphisms of the neurotrophic factor-3 (NTF-3) in Alzheimer's disease: rs6332 associated with onset time and rs6489630 T allele exhibited a protective role.
abstract: Because of its implications in neuroprotection, formation of long lasting memories and a disturbed function in Alzheimer's disease (AD), neurotrophin-3 (NTF-3) may represent an appropriate candidate gene conferring risk to AD. Recently, two single nucleotide polymorphisms (SNPs) (rs6489630 and rs6332) within the NTF-3 gene have been associated with AD in a Japanese population. Because of the importance of this finding, we analyzed the NTF-3 polymorphism in a Han Chinese sample consisting of 138 AD patients and 115 age-matched normal controls (NCs). In ApoE-ɛ4 non-carriers, a negative gene dose-association was found between the A allele of rs6332 and the onset time of AD. Individuals homozygous for the A allele developed AD significantly earlier than those homozygous for the G allele (mean age ± SD: 63.72 ± 9.08 versus 69.75 ± 6.03, p = 0.023). Moreover, in male subjects, we found the rs6489630 T allele to be protective against AD (OR 0.494; 95% CI 0.274-0.891; p value = 0.018) compared to C allele carriers. Due to a small number of patients showing homozygosity for the T allele in rs6489630 (n = 5), all of which were normal subjects, the result needs to be confirmed in a larger sample. The results suggest a gene dose-association between the A allele of rs6332 and the onset of AD in ɛ4 non-carriers, as well as the NTF-3 rs6489630 polymorphism being a relevant risk factor for AD in patients lacking the ApoE-ɛ4 allele in this Chinese sample.
authors.affiliation: a Department of Neurology .|b Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin HuanHu Hospital , Tianjin , China , and.
authors.forename: Mengyuan
authors.initials: M
authors.lastname: Liu
authors.affiliation: c School of Medicine, University of New South Wales , Kensington , NSW , Australia.
authors.forename: Ya Ruth
authors.initials: YR
authors.lastname: Huo
authors.affiliation: a Department of Neurology .
authors.forename: Junwei
authors.initials: J
authors.lastname: Wang
authors.affiliation: a Department of Neurology .
authors.forename: Shuling
authors.initials: S
authors.lastname: Liu
authors.affiliation: a Department of Neurology .
authors.forename: Shuai
authors.initials: S
authors.lastname: Liu
authors.affiliation: a Department of Neurology .
authors.forename: Change
authors.initials: C
authors.lastname: Wang
authors.affiliation: a Department of Neurology .|b Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin HuanHu Hospital , Tianjin , China , and.
authors.forename: Jinhuan
authors.initials: J
authors.lastname: Wang
authors.affiliation: a Department of Neurology .|b Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin HuanHu Hospital , Tianjin , China , and.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ji
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D000704:Analysis of Variance; D001057:Apolipoproteins E / Q000235:genetics; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D013223:Statistics as Topic
chemical_list: D001057:Apolipoproteins E; D009414:Nerve Growth Factors
keywords: APOE; Alzheimer’s disease; neurotrophin; polymorphism