title: Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015.
abstract: During the 2015 Middle East respiratory syndrome coronavirus outbreak in South Korea, we sequenced full viral genomes of strains isolated from 4 patients early and late during infection. Patients represented at least 4 generations of transmission. We found no evidence of changes in the evolutionary rate and no reason to suspect adaptive changes in viral proteins.
authors.forename: Moon-Woo
authors.initials: MW
authors.lastname: Seong
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Victor Max
authors.initials: VM
authors.lastname: Corman
authors.forename: Taek Soo
authors.initials: TS
authors.lastname: Kim
authors.forename: Sung Im
authors.initials: SI
authors.lastname: Cho
authors.forename: Man Jin
authors.initials: MJ
authors.lastname: Kim
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Lee
authors.forename: Jee-Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Seo
authors.forename: Ji Soo
authors.initials: JS
authors.lastname: Ahn
authors.forename: Byeong Su
authors.initials: BS
authors.lastname: Yu
authors.forename: Nare
authors.initials: N
authors.lastname: Park
authors.forename: Myoung-don
authors.initials: MD
authors.lastname: Oh
authors.forename: Wan Beom
authors.initials: WB
authors.lastname: Park
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Lee
authors.forename: Gayeon
authors.initials: G
authors.lastname: Kim
authors.forename: Joon Sung
authors.initials: JS
authors.lastname: Joh
authors.forename: Ina
authors.initials: I
authors.lastname: Jeong
authors.forename: Eui Chong
authors.initials: EC
authors.lastname: Kim
authors.forename: Christian
authors.initials: C
authors.lastname: Drosten
authors.forename: Sung Sup
authors.initials: SS
authors.lastname: Park
mesh_terms: D000328:Adult; D018352:Coronavirus Infections / Q000453:epidemiology* / Q000266:history / Q000635:transmission / Q000821:virology*; D004196:Disease Outbreaks; D019143:Evolution, Molecular; D014644:Genetic Variation; D016679:Genome, Viral; D049674:History, 21st Century; D006801:Humans; D008297:Male; D065207:Middle East Respiratory Syndrome Coronavirus / Q000235:genetics* / Q000302:isolation & purification; D056910:Republic of Korea / Q000453:epidemiology
keywords: MERS-CoV; Middle East respiratory syndrome; South Korea; coronavirus; genome sequencing; microevolution; outbreak; phylogenetic analysis; respiratory infections; viruses
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