title: Neural network modelling of the influence of channelopathies on reflex visual attention.
abstract: This paper introduces a model of Emergent Visual Attention in presence of calcium channelopathy (EVAC). By modelling channelopathy, EVAC constitutes an effort towards identifying the possible causes of autism. The network structure embodies the dual pathways model of cortical processing of visual input, with reflex attention as an emergent property of neural interactions. EVAC extends existing work by introducing attention shift in a larger-scale network and applying a phenomenological model of channelopathy. In presence of a distractor, the channelopathic network's rate of failure to shift attention is lower than the control network's, but overall, the control network exhibits a lower classification error rate. The simulation results also show differences in task-relative reaction times between control and channelopathic networks. The attention shift timings inferred from the model are consistent with studies of attention shift in autistic children.
authors.affiliation: Centre for Computational Intelligence (C2i), Nanyang Technological University, N4-B1A-02, Nanyang Avenue, 639798 Singapore, Singapore.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Gravier
authors.affiliation: School of Computer Engineering, Nanyang Technological University, Singapore, Singapore.
authors.forename: Chai
authors.initials: C
authors.lastname: Quek
authors.affiliation: Department of Informatics, School of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Torun, Poland.
authors.forename: Włodzisław
authors.initials: W
authors.lastname: Duch
authors.affiliation: School of Information and Communication Technology, International Islamic University of Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Abdul
authors.initials: A
authors.lastname: Wahab
authors.affiliation: School of Humanities and Social Sciences, Nanyang Technological University, Singapore, Singapore.
authors.forename: Joanna
authors.initials: J
authors.lastname: Gravier-Rymaszewska
keywords: Autism; Calcium channelopathy; Neural network; Task learning; Visual attention
references.citation: Cogn Neurodyn. 2011 Jun;5(2):145-60
references.pmid: 22654987
references.citation: Neural Netw. 2008 Oct;21(8):1146-52
references.pmid: 18684591
references.citation: J Physiol Paris. 2003 Jul-Nov;97(4-6):491-502
references.pmid: 15242659
references.citation: Nat Rev Genet. 2014 Feb;15(2):133-41
references.pmid: 24430941
references.citation: Curr Opin Neurobiol. 2007 Feb;17(1):112-9
references.pmid: 17275285
references.citation: J Immunol. 1998 Sep 15;161(6):2938-43
references.pmid: 9743356
references.citation: Brain Res Cogn Brain Res. 2001 Mar;11(1):127-45
references.pmid: 11240116
references.citation: Psychol Rev. 2006 Jul;113(3):483-525
references.pmid: 16802879
references.citation: Cogn Neurodyn. 2009 Jun;3(2):131-40
references.pmid: 19130301
references.citation: PLoS One. 2007 Oct 17;2(10):e1049
references.pmid: 17940613
references.citation: J Child Psychol Psychiatry. 2009 May;50(5):637-42
references.pmid: 19298466
references.citation: Ann N Y Acad Sci. 2009 Jan;1151:133-56
references.pmid: 19154521
references.citation: Acta Neuropathol. 2006 Sep;112(3):287-303
references.pmid: 16819561
references.citation: J Leukoc Biol. 1999 Jun;65(6):786-91
references.pmid: 10380900
references.citation: J Bioenerg Biomembr. 1998 Aug;30(4):409-18
references.pmid: 9758336
references.citation: Mol Neurobiol. 2011 Aug;44(1):83-92
references.pmid: 21691713
references.citation: J Opt Soc Am. 1967 Aug;57(8):1024-9
references.pmid: 6035296
references.citation: Circ Res. 2002 May 17;90(9):933-5
references.pmid: 12016257
references.citation: Cogn Neurodyn. 2009 Mar;3(1):1-8
references.pmid: 19003454
references.citation: Q J Exp Psychol. 1980 Feb;32(1):3-25
references.pmid: 7367577
references.citation: J Int Neuropsychol Soc. 1996 Nov;2(6):541-50
references.pmid: 9375158
references.citation: Mol Psychiatry. 2010 Jan;15(1):38-52
references.pmid: 18607376
references.citation: Neural Netw. 2010 May;23(4):487-96
references.pmid: 20045631
references.citation: J Cell Biol. 2003 Oct 27;163(2):283-93
references.pmid: 14568989
references.citation: Subcell Biochem. 2007;45:215-51
references.pmid: 18193639
references.citation: J Physiol. 1952 Aug;117(4):500-44
references.pmid: 12991237
references.citation: J Leukoc Biol. 2006 Jul;80(1):1-15
references.pmid: 16698940
references.citation: Ann Neurol. 2005 Jan;57(1):67-81
references.pmid: 15546155
references.citation: Cogn Neurodyn. 2009 Sep;3(3):223-42
references.pmid: 19125356
references.citation: Behav Neurosci. 1994 Oct;108(5):848-65
references.pmid: 7826509
references.citation: Mol Autism. 2012 Dec 15;3(1):18
references.pmid: 23241247
references.citation: Cogn Neurodyn. 2007 Dec;1(4):275-85
references.pmid: 19003498
references.citation: J Math Biol. 1982;15(3):267-73
references.pmid: 7153672
references.citation: Biol Psychiatry. 2001 Oct 15;50(8):614-9
references.pmid: 11690597
references.citation: Cogn Neurosci. 2010 Mar;1(1):52-62
references.pmid: 24168245
references.citation: Cell. 2004 Oct 1;119(1):19-31
references.pmid: 15454078
references.citation: Curr Opin Neurobiol. 1994 Apr;4(2):157-65
references.pmid: 8038571
references.citation: Int J Dev Neurosci. 2005 Apr-May;23(2-3):143-52
references.pmid: 15749241
references.citation: J Biol Chem. 1998 Mar 27;273(13):7205-9
references.pmid: 9516412
references.citation: Cogn Neurodyn. 2011 Mar;5(1):103-11
references.pmid: 22379499
references.citation: Br J Pharmacol. 2006 Jan;147 Suppl 1:S56-62
references.pmid: 16402121