title: Admission serum lactate predicts mortality in aneurysmal subarachnoid hemorrhage.
abstract: BACKGROUND
  Aneurysmal subarachnoid hemorrhage (SAH) is the most devastating form of hemorrhagic stroke. Primary predictors of mortality are based on initial clinical presentation. Initial serum lactic acid levels have been shown to predict mortality and disease severity. Initial serum lactate may be an objective predictor or mortality.
  
  
  METHODS
  Retrospective review of aneurysmal SAH in a large academic center over a 42-month period. Data collected included demographics, clinical data, serum, and clinical outcomes data. Epidemiologic data were collected at baseline, and patients were followed up through their inpatient stay. We compared data in the group of patients who were deceased (group A) vs survivors (group B).
  
  
  RESULTS
  There were a total of 249 patients. Mortality was 21.5%. Mean age was the same for both groups: 57 years (group A) and 55 years (group B). Mean admission serum lactate level was 3.5 ± 2.5 (group A) and 2.2 ± 1.6 (group B; P <. 0001). The range was 0.01 to 14.7. Multivariable analysis controlling for Hunt and Hess grades showed lactic acid levels to be an independent predictor of mortality with a P value of .0018.
  
  
  CONCLUSIONS
  In aneurysmal SAH, elevated serum lactate levels on admission may have a predictive role for mortality and represent a marker of disease severity. Currently, lactic acid levels are not ordered on all patients with SAH but perhaps should be part of the routine initial blood work and may serve as an additional prognostic marker.
authors.affiliation: Harvard University/Brigham and Womens Hospital, Boston, MA. Electronic address: iaisiku@partners.org.
authors.forename: Imo P
authors.initials: IP
authors.lastname: Aisiku
authors.affiliation: University of Texas Health Science Center Houston, Houston, TX. Electronic address: Peng.R.Chen@uth.tmc.edu.
authors.forename: Peng Roc
authors.initials: PR
authors.lastname: Chen
authors.affiliation: 2609 Wooded Canyon, Katy, TX. Electronic address: Htruong333@gmail.com.
authors.forename: Hanh
authors.initials: H
authors.lastname: Truong
authors.affiliation: University of Texas Health Science Center Houston, Houston, TX. Electronic address: Daniel.R.Monsivais@uth.tmc.edu.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Monsivais
authors.affiliation: Harvard University/Beth Israel Deaconnes Hospital, Boston, MA. Electronic address: jedlow@bidmc.harvard.edu.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Edlow
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006760:Hospitalization; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000401:mortality*
chemical_list: D019344:Lactic Acid