title: Bovine papillomavirus type 7 in Italy: complete genomes and sequence variants.
abstract: Two novel bovine papillomavirus type 7 (BPV-7) variants have been identified in teat cutaneous papillomas affecting dairy cows in northern Italy. The entire genome sequences of two BPV-7 Italian variants showed major sequence differences in the long control region (LCR) and in the L2 gene compared to the Japanese reference strain. In order to define the stability of these genetic variants, the L2 and LCR sequences of seven further BPV-7 positive isolates were characterized. An insertion of six amino acids in the L2 structural protein has been detected in all samples while different genetic variants have been identified for the LCR. These findings provide new insights on intra-type variability of BPVs and represent a starting point for future studies aimed at establishing the biological role of the different BPV genomic regions and investigating the pathogenic potential of papillomavirus variants.
authors.affiliation: Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano Emilia, Bologna, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Savini
authors.affiliation: Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano Emilia, Bologna, Italy. laura.gallina@unibo.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Gallina
authors.affiliation: Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Via Vienna 2, 07100, Sassari, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Alberti
authors.affiliation: Infections and Cancer Program, German Cancer Research Center (DKFZ), F035, Im Neuenheimer Feld 242, 69120, Heidelberg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Müller
authors.affiliation: Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano Emilia, Bologna, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Scagliarini
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000821:virology; D023061:Gene Order; D014644:Genetic Variation; D016679:Genome, Viral; D023281:Genomics; D007558:Italy; D016366:Open Reading Frames; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000662:veterinary; D010802:Phylogeny; D017422:Sequence Analysis, DNA
keywords: BPV-7; L2; LCR; Papillomavirus; Variants
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