title: "Thunderstruck": Plasma-Polymer-Coated Porous Silicon Microparticles As a Controlled Drug Delivery System.
abstract: Controlling the release kinetics from a drug carrier is crucial to maintain a drug's therapeutic window. We report the use of biodegradable porous silicon microparticles (pSi MPs) loaded with the anticancer drug camphothecin, followed by a plasma polymer overcoating using a loudspeaker plasma reactor. Homogenous "Teflon-like" coatings were achieved by tumbling the particles by playing AC/DC's song "Thunderstruck". The overcoating resulted in a markedly slower release of the cytotoxic drug, and this effect correlated positively with the plasma polymer coating times, ranging from 2-fold up to more than 100-fold. Ultimately, upon characterizing and verifying pSi MP production, loading, and coating with analytical methods such as time-of-flight secondary ion mass spectrometry, scanning electron microscopy, thermal gravimetry, water contact angle measurements, and fluorescence microscopy, human neuroblastoma cells were challenged with pSi MPs in an in vitro assay, revealing a significant time delay in cell death onset.
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia , Adelaide, South Australia 5001, Australia.
authors.forename: Steven J P
authors.initials: SJ
authors.lastname: McInnes
authors.affiliation: Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Michl
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia , Adelaide, South Australia 5001, Australia.
authors.forename: Bahman
authors.initials: B
authors.lastname: Delalat
authors.affiliation: Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Sameer A
authors.initials: SA
authors.lastname: Al-Bataineh
authors.affiliation: Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Bryan R
authors.initials: BR
authors.lastname: Coad
authors.affiliation: Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Krasimir
authors.initials: K
authors.lastname: Vasilev
authors.affiliation: Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Griesser
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia , Adelaide, South Australia 5001, Australia.
authors.forename: Nicolas H
authors.initials: NH
authors.lastname: Voelcker
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D002166:Camptothecin / Q000627:therapeutic use*; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D008855:Microscopy, Electron, Scanning; D009447:Neuroblastoma / Q000188:drug therapy*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use; D016062:Porosity; D012825:Silicon / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers; D002166:Camptothecin; D012825:Silicon
keywords: controlled drug release; fluorinated coating; particle coating; plasma polymerization; porous silicon