title: Atherosclerosis and Nanotechnology: Diagnostic and Therapeutic Applications.
abstract: Over the past several decades, tremendous advances have been made in the understanding, diagnosis, and treatment of coronary artery disease (CAD). However, with shifting demographics and evolving risk factors we now face new challenges that must be met in order to further advance are management of patients with CAD. In parallel with advances in our mechanistic appreciation of CAD and atherosclerosis, nanotechnology approaches have greatly expanded, offering the potential for significant improvements in our diagnostic and therapeutic management of CAD. To realize this potential we must go beyond to recognize new frontiers including knowledge gaps between understanding atherosclerosis to the translation of targeted molecular tools. This review highlights nanotechnology applications for imaging and therapeutic advancements in CAD.
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, Ann Arbor, MI, 48109, USA.|Department of Internal Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Kratz
authors.affiliation: Department of Internal Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
authors.forename: Ashish
authors.initials: A
authors.lastname: Chaddha
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, Ann Arbor, MI, 48109, USA.|Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
authors.forename: Somnath
authors.initials: S
authors.lastname: Bhattacharjee
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, Ann Arbor, MI, 48109, USA. sngoonew@med.umich.edu.|Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. sngoonew@med.umich.edu.
authors.forename: Sascha N
authors.initials: SN
authors.lastname: Goonewardena
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis* / Q000188:drug therapy*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D036103:Nanotechnology / Q000379:methods*; D012307:Risk Factors
keywords: Atherosclerosis; Endothelial cell; Inflammation; Macrophage; Molecular imaging; Nanotechnology
references.citation: Radiology. 2010 Sep;256(3):774-82
references.pmid: 20668118
references.citation: Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H450-7
references.pmid: 15277188
references.citation: Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1601-6
references.pmid: 16627809
references.citation: JACC Cardiovasc Imaging. 2012 Dec;5(12):1243-52
references.pmid: 23236975
references.citation: Circulation. 2006 Oct 3;114(14):1504-11
references.pmid: 17000904
references.citation: Sci Adv. 2015 Apr;1(3):null
references.pmid: 26295063
references.citation: Nat Methods. 2012 Jun;9(6):615-20
references.pmid: 22561987
references.citation: Nat Mater. 2014 Feb;13(2):125-38
references.pmid: 24452356
references.citation: Eur Heart J. 2012 Aug;33(15):1902-10
references.pmid: 21933781
references.citation: Circulation. 2007 Sep 11;116(11):1226-33
references.pmid: 17709641
references.citation: Annu Rev Immunol. 2002;20:197-216
references.pmid: 11861602
references.citation: Annu Rev Med. 2012;63:185-98
references.pmid: 21888516
references.citation: Circulation. 2009 Aug 18;120(7):592-9
references.pmid: 19652086
references.citation: Circulation. 2007 Jul 17;116(3):276-84
references.pmid: 17592078
references.citation: Circulation. 2003 Nov 4;108(18):2270-4
references.pmid: 14557370
references.citation: Nat Commun. 2014;5:3065
references.pmid: 24445279
references.citation: NMR Biomed. 2013 Jul;26(7):756-65
references.pmid: 23065771
references.citation: Trends Pharmacol Sci. 2010 May;31(5):199-205
references.pmid: 20172613
references.citation: Am J Pathol. 1993 Jul;143(1):164-72
references.pmid: 7686341
references.citation: Sci Transl Med. 2014 Jun 4;6(239):239sr1
references.pmid: 24898749
references.citation: J Pharm Sci. 1996 May;85(5):486-90
references.pmid: 8742939
references.citation: Exp Cell Res. 2013 May 15;319(9):1317-23
references.pmid: 23291327
references.citation: Eur Heart J. 2012 Jun;33(11):1309-17
references.pmid: 22507974
references.citation: Nat Med. 2002 Jul;8(7):757-60
references.pmid: 12091907
references.citation: Semin Immunopathol. 2013 Sep;35(5):553-62
references.pmid: 23839097
references.citation: Phys Med Biol. 2007 Aug 7;52(15):4679-96
references.pmid: 17634657
references.citation: Sci Transl Med. 2015 Feb 18;7(275):275ra20
references.pmid: 25695999
references.citation: Nat Med. 2007 May;13(5):636-41
references.pmid: 17417649
references.citation: AJR Am J Roentgenol. 2013 Mar;200(3):W304-13
references.pmid: 23436876
references.citation: J Am Coll Cardiol. 2010 Aug 17;56(8):653-61
references.pmid: 20705222
references.citation: Vascul Pharmacol. 2012 Aug 19;57(1):24-8
references.pmid: 22402259
references.citation: J Am Coll Cardiol. 1999 Mar;33(3):867-75
references.pmid: 10080492
references.citation: JACC Cardiovasc Imaging. 2010 Jul;3(7):761-71
references.pmid: 20633855
references.citation: Nat Rev Clin Oncol. 2010 Nov;7(11):653-64
references.pmid: 20838415
references.citation: PLoS Med. 2006 Nov;3(11):e442
references.pmid: 17132052
references.citation: Nanomedicine (Lond). 2006 Oct;1(3):321-9
references.pmid: 17716162
references.citation: Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):961-6
references.pmid: 17215360
references.citation: J Am Coll Cardiol. 2010 Apr 13;55(15):1629-38
references.pmid: 20378083
references.citation: Nat Rev Drug Discov. 2011 Nov;10(11):835-52
references.pmid: 22015921
references.citation: J Am Coll Cardiol. 2006 Nov 7;48(9):1818-24
references.pmid: 17084256
references.citation: Nat Biotechnol. 2011 Nov;29(11):1005-10
references.pmid: 21983520
references.citation: JACC Cardiovasc Interv. 2008 Apr;1(2):176-82
references.pmid: 19463297
references.citation: JACC Cardiovasc Imaging. 2012 Sep;5(9):941-55
references.pmid: 22974808
references.citation: FEBS Lett. 1995 Jan 3;357(2):140-4
references.pmid: 7805880
references.citation: Cerebrovasc Dis. 2012;34(2):169-73
references.pmid: 22922841
references.citation: Sci Transl Med. 2014 Jan 15;6(219):219ra7
references.pmid: 24431111
references.citation: J Am Coll Cardiol. 2009 Jun 2;53(22):2039-50
references.pmid: 19477353
references.citation: Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2103-9
references.pmid: 16825592
references.citation: Circ Res. 2002 Aug 23;91(4):281-91
references.pmid: 12193460
references.citation: Circ Res. 2013 Mar 1;112(5):755-61
references.pmid: 23300273
references.citation: PLoS One. 2013;8(3):e58761
references.pmid: 23554922
references.citation: Immunol Rev. 2007 Oct;219:187-203
references.pmid: 17850490
references.citation: J Nucl Med. 2009 Jun;50(6):959-65
references.pmid: 19443582
references.citation: Circulation. 2008 Jan 22;117(3):379-87
references.pmid: 18158358
references.citation: Mol Pharm. 2010 Dec 6;7(6):2020-9
references.pmid: 21028895
references.citation: J Am Coll Cardiol. 2005 Oct 4;46(7):1225-8
references.pmid: 16198835
references.citation: Arterioscler Thromb Vasc Biol. 2015 May;35(5):1050-5
references.pmid: 25792446
references.citation: Circulation. 2014 Feb 25;129(8):896-906
references.pmid: 24305567
references.citation: Circulation. 2002 Jun 11;105(23):2708-11
references.pmid: 12057982
references.citation: PLoS One. 2011;6(12):e28534
references.pmid: 22163030
references.citation: Pharm Res. 1994 Feb;11(2):206-12
references.pmid: 7909371
references.citation: Curr Probl Cardiol. 2003 Dec;28(12):625-53
references.pmid: 14691443
references.citation: Nano Lett. 2007 Dec;7(12):3759-65
references.pmid: 17979310
references.citation: JACC Cardiovasc Imaging. 2011 May;4(5):537-48
references.pmid: 21565743
references.citation: J Am Coll Cardiol. 2010 Jun 8;55(23):2527-35
references.pmid: 20513592
references.citation: J Am Coll Cardiol. 2014 Apr 29;63(16):1604-16
references.pmid: 24583311
references.citation: Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1444-51
references.pmid: 19608968