title: Metabolic syndrome and eye diseases.
abstract: Metabolic syndrome is becoming a worldwide medical and public health challenge as it has been seen increasing in prevalence over the years. Age-related eye diseases, the leading cause of blindness globally and visual impairment in developed countries, are also on the rise due to aging of the population. Many of the individual components of the metabolic syndrome have been shown to be associated with these eye diseases. However, the association of metabolic syndrome with eye diseases is not clear. In this review, we reviewed the evidence for associations between metabolic syndrome and certain ocular diseases in populations. We also reviewed the association of individual metabolic syndrome components with ocular diseases due to a paucity of research in this area. Besides, we also summarised the current understanding of etiological mechanisms of how metabolic syndrome or the individual components lead to these ocular diseases. With increasing evidence of such associations, it may be important to identify patients who are at risk of developing metabolic syndrome as prompt treatment and intervention may potentially decrease the risk of developing certain ocular diseases.
authors.affiliation: National University of Singapore, Singapore, Singapore.
authors.forename: Stanley
authors.initials: S
authors.lastname: Poh
authors.affiliation: Singapore Eye Research Institute, Singapore, Singapore.
authors.forename: Riswana Banu Binte
authors.initials: RB
authors.lastname: Mohamed Abdul
authors.affiliation: Singapore Eye Research Institute, Singapore, Singapore; Duke-NUS Medical School, Singapore, Singapore.
authors.forename: Ecosse L
authors.initials: EL
authors.lastname: Lamoureux
authors.affiliation: Singapore Eye Research Institute, Singapore, Singapore; Duke-NUS Medical School, Singapore, Singapore; Singapore National Eye Center, Singapore, Singapore.
authors.forename: Tien Y
authors.initials: TY
authors.lastname: Wong
authors.affiliation: Singapore Eye Research Institute, Singapore, Singapore; Duke-NUS Medical School, Singapore, Singapore. Electronic address: charumathi.sabanayagam@seri.com.sg.
authors.forename: Charumathi
authors.initials: C
authors.lastname: Sabanayagam
mesh_terms: D001766:Blindness; D003430:Cross-Sectional Studies; D005128:Eye Diseases / Q000209:etiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology
keywords: Age-related macular degeneration; Cataract; Diabetic retinopathy; Glaucoma; Metabolic syndrome; Observational studies