title: Improvement of Lesion Detection by Complete Angular Compound Ultrasonic Elastography.
abstract: Quasi-static ultrasound elastography is an emerging diagnostic imaging modality for determining the stiffness of pathologically changed soft tissues, which do not show significant differences in acoustic impedance for B-mode imaging. Although some methods were applied to improve the signal-to-noise ratio (SNRe) and contrast-to-noise ratio (CNRe) of the constructed elastogram, nonuniform strain distribution at the internal boundary of a hard inclusion, even with the uniform displacement on the surface, is an inherent mechanical effect and results in distortion at the detected lesion boundary. To overcome such stress concentrations, a new elastographic modality was proposed, where the elastograms from different angles throughout 360° were compounded. The strain field and subsequent ultrasound images were calculated using the finite element method (FEM) and Field II, respectively, from which the elastograms were constructed. The performance of complete angular compound elastography with varied interval angles, lesion sizes, and ratios of Young's moduli of the lesion to the background was simulated and compared with that of conventional axial strain elastography. It is found that viewing the lesion from only about 10 angles (interval of 36°) would significantly improve the image quality of elastogram (increasing SNRe by at least 13% and CNRe by at least 5.8 dB), reduce the lesion distortion in the lateral direction, and enhance the sensitivity, resolution, and accuracy of lesion detection. A preliminary phantom study showed similar improvements. Altogether, complete angular compound elastography improves the elastogram quality and reduces the mechanical effects in lesion detection.
authors.affiliation: 1 School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.
authors.forename: Chenhui
authors.initials: C
authors.lastname: Liu
authors.affiliation: 1 School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.|2 Key Laboratory of Modern Acoustics, Nanjing University, Nanjing, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhou
keywords: angular compounding; contrast-to-noise ratio; elastography; lesion size; signal-to-noise ratio; strain rate