title: Value of first-trimester serum lipid profile in early prediction of preeclampsia and its severity: A prospective cohort study.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the association of first-trimester serum lipid profile with preeclampsia (PE) and if so, its association with the severity of the disease.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  A total of 251 pregnant women participated in this study in their first trimester. Maternal blood samples were collected between 4 and 12 weeks of gestation. Fasting serum triglycerides (TGs), total cholesterol (TC), HDL-cholesterol, and low-density lipoprotein cholesterol (LDL-C) were drawn and measured by ELISA. From the cohort, 26 women developed PE (16 mild and 10 severe) and 174 remained normotensive and used as control subjects.
  
  
  RESULTS
  There was a significant rise in fasting serum TGs, TC, and LDL-C and a significant decrease in HDL-C in women who developed PE than in those who remained normotensive and more significantly evident in severe preeclamptic cases compared to mild cases of PE (p < 0.05).
  
  
  CONCLUSIONS
  Early pregnancy dyslipidemia, particularly hypertriglyceridemia and hypercholesterolemia, may help in predicting women who later develop PE and may help in prediction of its severity.
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Menoufia University , Shibin Elkom , Egypt.
authors.forename: Nabih I
authors.initials: NI
authors.lastname: El Khouly
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Menoufia University , Shibin Elkom , Egypt.
authors.forename: Zakaria F
authors.initials: ZF
authors.lastname: Sanad
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Menoufia University , Shibin Elkom , Egypt.
authors.forename: Said A
authors.initials: SA
authors.lastname: Saleh
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Menoufia University , Shibin Elkom , Egypt.
authors.forename: Ayman A
authors.initials: AA
authors.lastname: Shabana
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Menoufia University , Shibin Elkom , Egypt.
authors.forename: Alaa F
authors.initials: AF
authors.lastname: Elhalaby
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Menoufia University , Shibin Elkom , Egypt.
authors.forename: Eman E
authors.initials: EE
authors.lastname: Badr
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011446:Prospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D008055:Lipids
keywords: Dyslipidemia; lipid profile; preeclampsia