title: ATAD2 overexpression is associated with progression and prognosis in colorectal cancer.
abstract: OBJECTIVE
  ATPase family AAA domain-containing 2 plays an important role in tumor progression including cell cycle, proliferation, apoptosis and chemoresistance. However, the expression of ATPase family AAA domain-containing 2 in colorectal cancer and its significance are still unclear. The aim of this study was to examine the expression of ATPase family AAA domain-containing 2 in colorectal cancer.
  
  
  METHODS
  Immunohistochemistry was used to determine the expression of ATPase family AAA domain-containing 2 in 155 colorectal cancer and 30 matched adjacent noncancerous tissues. The correlation of ATPase family AAA domain-containing 2 expression with clinicopathological variables was assessed using chi-square test. Patient survival was analyzed using the Kaplan-Meier and log-rank tests. Cox regression was performed for the multivariate analysis of prognostic factors.
  
  
  RESULTS
  High expression of ATPase family AAA domain-containing 2 was detected in 58.1% of the colorectal cancers and was significantly associated with advanced tumor-node-metastasis stage (P = 0.044), poor differentiation (P = 0.028), deep infiltration (P < 0.001), lymphovascular invasion (P = 0.006), lymph node metastasis (P = 0.024) and recurrence (P = 0.022). Patients with high ATPase family AAA domain-containing 2 expression had significantly poorer overall survival and disease-free survival (both P < 0.001) when compared with patients with low expression of ATPase family AAA domain-containing 2. The multivariate analysis showed that ATPase family AAA domain-containing 2 was an independent factor for both overall survival (P = 0.003; hazard ratio (HR): 2.356; 95% confidence interval (CI): 1.335-4.158) and disease-free survival (P = 0.001; HR: 2.643; 95% CI: 1.489-4.693).
  
  
  CONCLUSIONS
  These results showed that ATPase family AAA domain-containing 2 overexpression was associated with progression and prognosis of colorectal cancer.
authors.affiliation: Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin.
authors.forename: Mingming
authors.initials: M
authors.lastname: Hou
authors.affiliation: Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin.
authors.forename: Rui
authors.initials: R
authors.lastname: Huang
authors.affiliation: Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin.
authors.forename: Yanni
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Pathology, The Third Affiliated Hospital of Harbin Medical University, Harbin.
authors.forename: Di
authors.initials: D
authors.lastname: Feng
authors.affiliation: Department of Pathology, The Third Affiliated Hospital of Harbin Medical University, Harbin.
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China herodoc@126.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000251:Adenosine Triphosphatases; C544857:ATAD2 protein, human; D000074183:ATPases Associated with Diverse Cellular Activities
keywords: ATAD2; colorectal cancer; immunohistochemistry; prognosis