title: Atopic dermatitis is not associated with actinic keratosis: cross-sectional results from the Rotterdam study.
abstract: BACKGROUND
  Epidermal barrier impairment and an altered immune system in atopic dermatitis (AD) may predispose to ultraviolet-induced DNA damage.
  
  
  OBJECTIVE
  To study the association between AD and actinic keratosis (AK) in a population-based cross-sectional study.
  
  
  METHODS
  AD was defined by modified criteria of the U.K. working party's diagnostic criteria. AKs were diagnosed by physicians during a full-body skin examination, and keratinocyte cancers were identified via linkage to the national pathology database. The results were analysed in adjusted multivariable and multinomial models.
  
  
  RESULTS
  A lower proportion of subjects with AD had AKs than those without AD: 16% vs. 24%, P = 0·002; unadjusted odds ratio (OR) 0·60, 95% confidence interval (CI) 0·42-0·83; adjusted OR 0·74, 95% CI 0·51-1·05; fully adjusted OR 0·69, 95% CI 0·47-1·07. In a multinomial model patients with AD were less likely to have ≥ 10 AKs (adjusted OR 0·28, 95% CI 0·09-0·90). No effect of AD on basal cell carcinoma or squamous cell carcinoma was found: adjusted OR 0·71, 95% CI 0·41-1·24 and adjusted OR 1·54, 95% CI 0·66-3·62, respectively.
  
  
  CONCLUSIONS
  AD in community-dwelling patients is not associated with AK.
authors.affiliation: Department of Dermatology and Venerology, Erasmus Medical Centre, Burgemeester s'Jacobplein 51, 3015 CA, Rotterdam, the Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Hajdarbegovic
authors.affiliation: Department of Dermatology and Venerology, Erasmus Medical Centre, Burgemeester s'Jacobplein 51, 3015 CA, Rotterdam, the Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Blom
authors.affiliation: Department of Dermatology and Venerology, Erasmus Medical Centre, Burgemeester s'Jacobplein 51, 3015 CA, Rotterdam, the Netherlands.
authors.forename: J A C
authors.initials: JA
authors.lastname: Verkouteren
authors.affiliation: Department of Epidemiology, Erasmus Medical Centre, Burgemeester s'Jacobplein 51, 3015 CA, Rotterdam, the Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Department of Dermatology and Venerology, Erasmus Medical Centre, Burgemeester s'Jacobplein 51, 3015 CA, Rotterdam, the Netherlands.
authors.forename: L M
authors.initials: LM
authors.lastname: Hollestein
authors.affiliation: Department of Dermatology and Venerology, Erasmus Medical Centre, Burgemeester s'Jacobplein 51, 3015 CA, Rotterdam, the Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Nijsten
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015603:Keratinocytes; D055623:Keratosis, Actinic / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology