title: Effects of Use and Disuse on Non-paralyzed and Paralyzed Skeletal Muscles.
abstract: Skeletal muscle is an integral part of the somatic nervous system and plays a primary role in the performance of physical activities. Because physical activity is vital to countering the effects of aging and age related diseases and is a key component in the maintenance of healthy body composition it is important to understand the effects of use and disuse on skeletal muscle. While voluntary muscle activity provides optimal benefits to muscle and the maintenance of healthy body composition, neuromuscular electrical stimulation may be a viable alternative activity for individuals with paralysis. Body composition with a healthy muscle to fat ratio has been associated with healthy blood lipid and glucose profiles that may decrease the risk of cardiovascular and metabolic diseases.
authors.affiliation: 1 School of Kinesiology, College of Health, University of Southern Mississippi, Hattiesburg, MS 39406, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Dolbow
authors.affiliation: 2 Spinal Cord Injury and Disorders Service, Hunter Holmes McGuire VAMC, Richmond, VA 23249, USA; 3 Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors.forename: Ashraf S
authors.initials: AS
authors.lastname: Gorgey
keywords: electrical stimulation; metabolic profile; muscle paralysis; skeletal muscle
references.citation: Arch Phys Med Rehabil. 1983 Mar;64(3):107-10
references.pmid: 6338859
references.citation: Am J Clin Nutr. 2008 Mar;87(3):600-7
references.pmid: 18326597
references.citation: Clin Orthop Relat Res. 1983 Oct;(179):275-83
references.pmid: 6617027
references.citation: Bone. 2008 Jul;43(1):169-176
references.pmid: 18440891
references.citation: Anat Rec A Discov Mol Cell Evol Biol. 2003 Dec;275(2):1081-101
references.pmid: 14613308
references.citation: J Appl Physiol (1985). 1990 Apr;68(4):1657-67
references.pmid: 2347805
references.citation: Clin Sci Mol Med. 1977 Sep;53(3):257-69
references.pmid: 913049
references.citation: Eur J Appl Physiol Occup Physiol. 1992;65(5):438-44
references.pmid: 1425650
references.citation: J Neurophysiol. 1987 Jun;57(6):1730-45
references.pmid: 3598628
references.citation: Horm Metab Res. 1995 Jun;27(6):287-92
references.pmid: 7557841
references.citation: FASEB J. 2004 Jun;18(9):1025-7
references.pmid: 15084522
references.citation: Eur J Appl Physiol Occup Physiol. 1999 Sep;80(4):373-8
references.pmid: 10483809
references.citation: Eur J Appl Physiol Occup Physiol. 1989;58(4):369-74
references.pmid: 2920715
references.citation: Spinal Cord. 2008 Jul;46(7):466-76
references.pmid: 18180789
references.citation: Med Sci Sports Exerc. 2002 Feb;34(2):364-80
references.pmid: 11828249
references.citation: J Appl Physiol (1985). 2004 Nov;97(5):1591-2
references.pmid: 15475545
references.citation: J Biomech. 1991;24 Suppl 1:123-33
references.pmid: 1791173
references.citation: Muscle Nerve. 2009 Oct;40(4):499-519
references.pmid: 19705475
references.citation: J Appl Physiol (1985). 1991 Apr;70(4):1882-5
references.pmid: 2055867
references.citation: J Neuropathol Exp Neurol. 2004 Sep;63(9):919-31
references.pmid: 15453091
references.citation: J Appl Physiol (1985). 1989 Dec;67(6):2600-7
references.pmid: 2606868
references.citation: Eur J Appl Physiol Occup Physiol. 1999 Sep;80(4):394-6
references.pmid: 10483812
references.citation: Metabolism. 2011 Jun;60(6):843-51
references.pmid: 20870252
references.citation: Arch Phys Med Rehabil. 2005 Jul;86(7):1502-4
references.pmid: 16003691
references.citation: J Orthop Res. 1993 Jan;11(1):131-41
references.pmid: 8423515
references.citation: Arch Phys Med Rehabil. 2002 Dec;83(12):1703-7
references.pmid: 12474173
references.citation: Spinal Cord. 2014 Jun;52 Suppl 1:S3-4
references.pmid: 24902644
references.citation: Med Eng Phys. 1995 Oct;17(7):529-36
references.pmid: 7489126
references.citation: Exerc Sport Sci Rev. 2007 Jul;35(3):102-9
references.pmid: 17620928
references.citation: J Spinal Cord Med. 2012 May;35(3):182-6
references.pmid: 22507029
references.citation: J Rehabil Res Dev. 2012;49(3):373-80
references.pmid: 22773197
references.citation: Diabetes. 1980 Nov;29(11):906-10
references.pmid: 7429029
references.citation: Arch Phys Med Rehabil. 2007 Jun;88(6):751-7
references.pmid: 17532897
references.citation: Arch Phys Med Rehabil. 1988 Aug;69(8):598-604
references.pmid: 3261577
references.citation: Spinal Cord. 2008 Mar;46(3):192-7
references.pmid: 17502877
references.citation: News Physiol Sci. 2001 Dec;16:256-61
references.pmid: 11719600
references.citation: Am J Physiol. 1997 Sep;273(3 Pt 2):R1072-9
references.pmid: 9321888
references.citation: Arch Phys Med Rehabil. 2005 Nov;86(11):2106-13
references.pmid: 16271556
references.citation: Eur J Appl Physiol. 2004 Mar;91(2-3):308-13
references.pmid: 14586584
references.citation: J Neurophysiol. 2006 Apr;95(4):2380-90
references.pmid: 16407424
references.citation: Appl Physiol Nutr Metab. 2011 Feb;36(1):107-14
references.pmid: 21326384
references.citation: Eur J Appl Physiol Occup Physiol. 1988;57(1):39-44
references.pmid: 3342791
references.citation: J Neurophysiol. 1986 Jun;55(6):1202-20
references.pmid: 3734855
references.citation: Curr Opin Clin Nutr Metab Care. 2012 May;15(3):240-5
references.pmid: 22466926
references.citation: Phys Ther. 1993 Dec;73(12):902-10
references.pmid: 8248298
references.citation: Eur J Appl Physiol. 2011 Oct;111(10):2409-26
references.pmid: 21805156
references.citation: PM R. 2010 Dec;2(12):1080-7
references.pmid: 21145519
references.citation: J Appl Physiol (1985). 1992 Dec;73(6):2517-23
references.pmid: 1490965
references.citation: Arch Phys Med Rehabil. 2003 Jul;84(7):1068-71
references.pmid: 12881836
references.citation: Metabolism. 1994 Jun;43(6):749-56
references.pmid: 8201966
references.citation: Am J Physiol. 1996 Sep;271(3 Pt 1):E593-600
references.pmid: 8843756
references.citation: J Rehabil Res Dev. 2008;45(2):261-72
references.pmid: 18566944
references.citation: J Orthop Sports Phys Ther. 2009 Sep;39(9):684-92
references.pmid: 19721215
references.citation: Med Sci Sports Exerc. 2006 Aug;38(8):1470-5
references.pmid: 16888461
references.citation: Spinal Cord. 2008 Jul;46(7):494-9
references.pmid: 18209743
references.citation: J Spinal Cord Med. 2007;30 Suppl 1:S127-39
references.pmid: 17874698
references.citation: J Appl Physiol (1985). 2001 Mar;90(3):865-72
references.pmid: 11181594
references.citation: J Sports Sci Med. 2005 Sep 01;4(3):263-71
references.pmid: 24453530
references.citation: Spinal Cord. 2005 Sep;43(9):513-8
references.pmid: 15824757
references.citation: Horm Metab Res. 1994 Mar;26(3):152-6
references.pmid: 8005564
references.citation: Spinal Cord. 2012 Feb;50(2):170-1
references.pmid: 22006083
references.citation: J Appl Physiol (1985). 2011 Jan;110(1):264-74
references.pmid: 21030673
references.citation: J Spinal Cord Med. 2014 Nov;37(6):693-702
references.pmid: 25001559
references.citation: Sports Med. 2004;34(11):727-51
references.pmid: 15456347
references.citation: JAMA. 2007 Apr 25;297(16):1772-4
references.pmid: 17456818
references.citation: Anat Rec. 1987 Sep;219(1):1-9
references.pmid: 3688455
references.citation: Endocr Rev. 1996 Oct;17(5):481-517
references.pmid: 8897022
references.citation: Phys Ther. 2009 Oct;89(10):1051-60
references.pmid: 19643834
references.citation: J Electromyogr Kinesiol. 2009 Aug;19(4):614-22
references.pmid: 18440241
references.citation: Med Sci Sports Exerc. 1988 Aug;20(4):338-44
references.pmid: 3173042
references.citation: Int J Sports Med. 1997 Oct;18 Suppl 4:S265-9
references.pmid: 9391829
references.citation: Am J Physiol Cell Physiol. 2003 Mar;284(3):C738-48
references.pmid: 12444021
references.citation: Paraplegia. 1992 Oct;30(10):697-703
references.pmid: 1448297
references.citation: J Rehabil Res Dev. 2004 Jan-Feb;41(1):1-8
references.pmid: 15273892
references.citation: Med Sci Sports Exerc. 2012 Jan;44(1):165-74
references.pmid: 21659900
references.citation: Calcif Tissue Int. 1997 Jul;61(1):22-5
references.pmid: 9192506
references.citation: J Spinal Cord Med. 2012 Mar;35(2):107-12
references.pmid: 22525324
references.citation: J Appl Physiol (1985). 2002 Jan;92(1):147-54
references.pmid: 11744654
references.citation: Spinal Cord. 1997 Feb;35(2):86-91
references.pmid: 9044514
references.citation: Spinal Cord. 2007 Apr;45(4):304-9
references.pmid: 16940987
references.citation: Phys Med Rehabil Clin N Am. 2007 May;18(2):333-51, vii
references.pmid: 17543776
references.citation: J Appl Physiol (1985). 1996 Jan;80(1):158-65
references.pmid: 8847297
references.citation: J Spinal Cord Med. 2001 Winter;24(4):266-77
references.pmid: 11944785
references.citation: J Spinal Cord Med. 2011;34(1):99-109
references.pmid: 21528633
references.citation: J Appl Physiol (1985). 2004 Mar;96(3):885-92
references.pmid: 14578365
references.citation: J Appl Physiol (1985). 2000 Apr;88(4):1310-5
references.pmid: 10749824
references.citation: NeuroRehabilitation. 2011;29(3):261-9
references.pmid: 22142760
references.citation: Scand J Rehabil Med. 1976;8(1):37-42
references.pmid: 132700
references.citation: J Appl Physiol (1985). 2003 Dec;95(6):2398-407
references.pmid: 12909613
references.citation: J Rehabil Med. 2002 Jan;34(1):25-32
references.pmid: 11900259
references.citation: J Clin Pharmacol. 2006 Apr;46(4):476-82
references.pmid: 16554457
references.citation: J Spinal Cord Med. 2010;33(1):6-15
references.pmid: 20397439
references.citation: Spinal Cord. 2004 Dec;42(12):711-6
references.pmid: 15303112
references.citation: Med Sci Sports Exerc. 2007 Aug;39(8):1423-34
references.pmid: 17762377
references.citation: Arch Phys Med Rehabil. 2005 Jun;86(6):1176-81
references.pmid: 15954057
references.citation: Sports Med. 1997 Jan;23(1):48-60
references.pmid: 9017859
references.citation: Disabil Rehabil. 2005 Nov 30;27(22):1337-41
references.pmid: 16321917
references.citation: Muscle Nerve. 2004 Aug;30(2):209-15
references.pmid: 15266637
references.citation: Spinal Cord. 2006 Apr;44(4):227-33
references.pmid: 16158074
references.citation: Obes Res. 2003 Apr;11(4):563-70
references.pmid: 12690086