title: Clinical course of primary sclerosing cholangitis and concomitant ulcerative colitis - a preliminary report of retrospective study among patients from Southern Poland.
abstract: Both ulcerative colitis (UC) and primary sclerosing cholangitis (PSC) are chronic and progressive diseases of uncertain etiology, that may affect one patient. Approximately 70% of PSC cases are also diagnosed with UC, whereas in the group of UC the prevalence of PSC is about 2-5%. The aim of the study was to compare clinical courses of PSC and UC in patients diagnosed with both diseases to those with the confirmed diagnosis of either PSC or UC. Three groups were distinguished and evaluated: patients with PSC and UC (n = 17) and two control groups: patients with PSC (n = 4) and with UC (n = 13). Clinical data, symptoms, laboratory tests, results of the magnetic resonance cholangiopancreatography and colonoscopy were analyzed to compare clinical courses of these diseases between the groups.
  
  
  CONCLUSIONS
  there is no correlation between clinical course of simultaneous PSC and UC. However, it may differ depending on co-occurrence of the other disease.
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Śniadeckich 5, Krakow, Poland. glowacki@cm-uj.krakow.pl.
authors.forename: Mikołaj K
authors.initials: MK
authors.lastname: Głowacki
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Zwolińska-Wcisło
authors.forename: Paulina
authors.initials: P
authors.lastname: Frączek
authors.forename: Martyna
authors.initials: M
authors.lastname: Gomulska
authors.forename: Danuta
authors.initials: D
authors.lastname: Owczarek
authors.forename: Dorota
authors.initials: D
authors.lastname: Cibor
authors.forename: Andrzej
authors.initials: A
authors.lastname: Cieśla
authors.forename: Tomasz
authors.initials: T
authors.lastname: Mach
mesh_terms: D000328:Adult; D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde; D015209:Cholangitis, Sclerosing / Q000175:diagnosis* / Q000628:therapy*; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000628:therapy*; D003113:Colonoscopy; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
keywords: autoimmune liver disease; inflammatory bowel disease; primary sclerosing cholangitis; ulcerative colitis