title: Pharmacokinetic and Dynamic of Furosemide in Peritoneal Dialysis Patients.
abstract: The aim of our study was to evaluate the efficacy and bioavailibility of a commonly used oral furosemide dose (500 mg) compared to a 250 mg intravenous (IV) dose in PD patients with significant residual renal function (urine volume > 100 mL). We also evaluated the immediate blood pressure effect in these patients. The data were obtained from a study we performed for the homologation of a 500-mg dose of furosemide by Health Canada.
authors.affiliation: Department of nephrology, Maisonneuve-Rosemont Hospital, Montreal, Canada.
authors.forename: Caroline
authors.initials: C
authors.lastname: Lamarche
authors.affiliation: Department of nephrology, Maisonneuve-Rosemont Hospital, Montreal, Canada.
authors.forename: Maude
authors.initials: M
authors.lastname: Pichette
authors.affiliation: Department of nephrology, Maisonneuve-Rosemont Hospital, Montreal, Canada.
authors.forename: Denis
authors.initials: D
authors.lastname: Ouimet
authors.affiliation: Department of nephrology, Maisonneuve-Rosemont Hospital, Montreal, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Vallée
authors.affiliation: Department of nephrology, Maisonneuve-Rosemont Hospital, Montreal, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Bell
authors.affiliation: Department of nephrology, Maisonneuve-Rosemont Hospital, Montreal, Canada.
authors.forename: Georges
authors.initials: G
authors.lastname: Ouellet
authors.affiliation: Sanofi Canada, Laval, Quebec.
authors.forename: John
authors.initials: J
authors.lastname: Stewart
authors.affiliation: Department of nephrology, Maisonneuve-Rosemont Hospital, Montreal, Canada Maisonneuve-Rosemont Hospital Research Center, Montreal, Canada vpichette.hmr@ssss.gouv.qc.ca.
authors.forename: Vincent
authors.initials: V
authors.lastname: Pichette
mesh_terms: D004232:Diuretics / Q000493:pharmacokinetics*; D005260:Female; D005665:Furosemide / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis
chemical_list: D004232:Diuretics; D005665:Furosemide
keywords: Furosemide; blood pressure; diuresis; natriuresis; pharmacodynamic; pharmacokinetic
references.citation: Perit Dial Int. 2003 Jul-Aug;23(4):339-47
references.pmid: 12968841
references.citation: CANNT J. 2006 Jul-Sep;16(3):40-4
references.pmid: 17061696
references.citation: Cardiovasc Res. 1996 Dec;32(6):988-97
references.pmid: 9015400
references.citation: J Am Soc Nephrol. 2001 Oct;12(10):2158-62
references.pmid: 11562415
references.citation: Cochrane Database Syst Rev. 2012 Aug 15;(8):CD003825
references.pmid: 22895937