title: Pharmacological basis for the use of Hypericum oblongifolium as a medicinal plant in the management of pain, inflammation and pyrexia.
abstract: BACKGROUND
  The present therapeutic agents for the treatment of pain, inflammation and pyrexia are not very effective and accompanied by various side effects. Therefore, new effective agents are the most wanted. The present study investigates the anti-nociceptive, anti-inflammatory and antipyretic activities of crude methanol extract of Hypericum oblongifolium.
  
  
  METHODS
  In vivo acetic acid induced writhing and hot plate tests were used for antinociceptive effects at 100, 200 and 300 mg/kg i.p. The anti-inflammatory and antipyretic potential of methanol extract were tested in carrageenan induced paw edema in mice and yeast induced hyperthermia respectively.
  
  
  RESULTS
  The extract doses of 100, 200 and 300 mg/kg i.p. revealed significant inhibitory effect (P < 0.001) in acetic acid induced writhing test. Pretreatment of extract at doses of 100, 200 and 300 mg/kg i.p. produced significant anti-inflammatory effect (P < 0.001) in the carrageenan induced paw edema. The methanol extract also showed significant antipyretic effect in yeast induced hyperthermia in mice during various assessment times.
  
  
  CONCLUSIONS
  The methanol extract of H. oblongifolium showed significant anti-nociceptive, anti-inflammatory and antipyretic effects in various animal models and thus validates the traditional uses of the plant in said conditions.
authors.affiliation: Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan.|Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan.
authors.forename: Naila
authors.initials: N
authors.lastname: Raziq
authors.affiliation: Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan. saeedrph2000@yahoo.com.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saeed
authors.affiliation: Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Shahid
authors.affiliation: Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan.
authors.forename: Naveed
authors.initials: N
authors.lastname: Muhammad
authors.affiliation: Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan.
authors.forename: Farah
authors.initials: F
authors.lastname: Gul
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000188:drug therapy*; D020902:Hypericum / Q000737:chemistry*; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts
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