title: Mouse models for gastric cancer: Matching models to biological questions.
abstract: Gastric cancer is the third leading cause of cancer-related mortality worldwide. This is in part due to the asymptomatic nature of the disease, which often results in late-stage diagnosis, at which point there are limited treatment options. Even when treated successfully, gastric cancer patients have a high risk of tumor recurrence and acquired drug resistance. It is vital to gain a better understanding of the molecular mechanisms underlying gastric cancer pathogenesis to facilitate the design of new-targeted therapies that may improve patient survival. A number of chemically and genetically engineered mouse models of gastric cancer have provided significant insight into the contribution of genetic and environmental factors to disease onset and progression. This review outlines the strengths and limitations of current mouse models of gastric cancer and their relevance to the pre-clinical development of new therapeutics.
authors.affiliation: Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.|The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
authors.forename: Ashleigh R
authors.initials: AR
authors.lastname: Poh
authors.affiliation: School of Cancer Medicine, La Trobe University, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.
authors.forename: Robert J J
authors.initials: RJ
authors.lastname: O'Donoghue
authors.affiliation: School of Cancer Medicine, La Trobe University, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.
authors.forename: Matthias
authors.initials: M
authors.lastname: Ernst
authors.affiliation: Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.|The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Putoczki
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005755:Gastrins; D016481:Helicobacter Infections; D044922:Helicobacter felis; D016480:Helicobacter pylori; D008770:Methylnitrosourea; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D058990:Molecular Targeted Therapy; D013274:Stomach Neoplasms / Q000145:classification / Q000209:etiology* / Q000235:genetics / Q000628:therapy
chemical_list: D005755:Gastrins; D008770:Methylnitrosourea
keywords: Helicobacter pylori; diffuse gastric cancer; intestinal-type gastric cancer; mouse model
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