title: Drug delivery function of carboxymethyl-β-cyclodextrin modified upconversion nanoparticles for adamantine phthalocyanine and their NIR-triggered cancer treatment.
abstract: Near-infrared (NIR) light triggered photodynamic therapy (PDT), based on upconversion nanoparticles (UCNPs), has attracted great attention because of its high tissue penetration and low photodamage to living organisms. However, most UCNPs cannot be stably dispersed in aqueous solution and cannot carry photosensitive drugs directly. Besides, UCNP mediated PDT is a fluorescence resonance energy transfer (FRET) process from the UCNPs to the attached photosensitive drugs. So the drug and UCNPs must be stably connected and close enough. In this manuscript, carboxymethyl-β-cyclodextrin (COOH-β-CD) was used to connect UCNPs and adamantine modified phthalocyanine (Ad-ZnPc) through a self-assembly process followed by a host-guest interaction. COOH-β-CD can provide good water solubility of the system and short-distance linking between the UCNPs and Ad-ZnPc. Most importantly, the system has a strong NIR light triggered PDT activity toward cancer cells.
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, P. R. China. zhoulin@njnu.edu.cn shwei@njnu.edu.cn.
authors.forename: Ao
authors.initials: A
authors.lastname: Wang
authors.forename: Weiwei
authors.initials: W
authors.lastname: Jin
authors.forename: Enyi
authors.initials: E
authors.lastname: Chen
authors.forename: Jiahong
authors.initials: J
authors.lastname: Zhou
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wei
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D007259:Infrared Rays; D054833:Isoindoles; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; C000612061:adamantine phthalocyanine; D047392:beta-Cyclodextrins; C441457:carboxymethyl-beta-cyclodextrin; D014867:Water; D000218:Adamantane; C013647:phthalocyanine