title: Familial Endocrine Syndromes.
abstract: Endocrine tumors may present as sporadic events or as part of familial endocrine syndromes. Familial endocrine syndromes (or inherited tumor/neoplasm syndromes) are characterized by multiple tumors in multiple organs. Some morphologic findings in endocrine tumor histopathology may prompt the possibility of familial endocrine syndromes, and these recognized histologic features may lead to further molecular genetic evaluation of the patient and family members. Subsequent evaluation for these syndromes in asymptomatic patients and family members may then be performed by genetic screening.
authors.affiliation: Pathology Service, Massachusetts General Hospital, Boston, MA, USA; Department of Pathology, Harvard Medical School, Boston, MA, USA.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Sadow
authors.affiliation: Pathology Service, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Hartford
authors.affiliation: Pathology Service, Massachusetts General Hospital, Boston, MA, USA; Department of Pathology, Harvard Medical School, Boston, MA, USA. Electronic address: vnose@partners.org.
authors.forename: Vania
authors.initials: V
authors.lastname: Nosé
keywords: Endocrine tumors; Familial diseases; Familial endocrine syndrome; Inherited neoplasm syndrome; Inherited tumor syndrome; Multiple endocrine neoplasia