title: A new acylated flavonol from the aerial parts of Asteriscus maritimus (L.) Less (Asteraceae).
abstract: Phytochemical investigation of the flowering aerial parts of Asteriscus maritimus (L.) Less (Asteraceae) led to the isolation of a new compound: patuletin 7-O-β-D-[(2″'S) 6″(3″'-hydroxy-2″'-methyl-propanoyl)] glucopyranoside, together with five known metabolites; β-sitosterol 2, chlorogenic acid 3, P-hydroxy -methylbenzoate 4, luteolin 5 and protocatechuic acid 6. The structures of the isolated compounds were determined by comprehensive analyses of its 1D and 2D NMR, HRMS and compared with previously known analogues. The ethanolic extract of the flowering aerial parts of A. maritimus was found to be safe (LD50 = 4.6 mg/kg) and possess significant antioxidant and anti-inflammatory activities and this was in accordance with its high phenolic content (107.36 ± 0.051 mg GAE/g extract).
authors.affiliation: a Faculty of Pharmacy, Pharmacognosy Department , Cairo University , Cairo , Egypt.
authors.forename: Marwa I
authors.initials: MI
authors.lastname: Ezzat
authors.affiliation: a Faculty of Pharmacy, Pharmacognosy Department , Cairo University , Cairo , Egypt.
authors.forename: Shahira M
authors.initials: SM
authors.lastname: Ezzat
authors.affiliation: a Faculty of Pharmacy, Pharmacognosy Department , Cairo University , Cairo , Egypt.
authors.forename: Kadriya S
authors.initials: KS
authors.lastname: El Deeb
authors.affiliation: a Faculty of Pharmacy, Pharmacognosy Department , Cairo University , Cairo , Egypt.
authors.forename: Ahlam M
authors.initials: AM
authors.lastname: El Fishawy
authors.affiliation: b Chemistry of Tannins Department , National Research Centre , Cairo , Egypt.
authors.forename: Sayed A
authors.initials: SA
authors.lastname: El-Toumy
mesh_terms: D000215:Acylation; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D051379:Mice; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D044948:Flavonols; D010936:Plant Extracts
keywords: Asteriscus maritimus; acylated flavonol; anti-inflammatory; antioxidant