title: Interleukin-16 rs4778889 polymorphism contributes to the development of renal cell cancer in a Chinese population.
abstract: We conducted a case-control study to assess the role of IL-16 rs4778889, rs11556218 and rs8034928 polymorphisms in the development of RCC. This case-control study included 181 patients with RCC and 278 control patients. The genotyping of IL-16 rs4778889, rs11556218 and rs8034928 polymorphisms were performed using polymerase chain reaction (PCR) combined with restriction fragment length polymorphism analysis. By χ(2) test, we found that patients with RCC were more likely to suffer from hypertension (χ(2) = 9.06, P = 0.003) and diabetes (χ(2) = 7.91, P = 0.005). By unconditional logistic regression analysis, the CC genotype of rs4778889 was associated with an increased risk of RCC compared to TT genotype, and the adjusted OR (95% CI) was 3.58 (1.59-8.31). In dominant model and recessive model, we found the rs4778889 polymorphisms were associated with an elevated increased risk of RCC, and the adjusted ORs (95% CI) were 1.64 (1.10-2.43) and 3.07 (1.40-6.98), respectively. We found that rs4778889 polymorphism had interaction with hypertension (OR = 2.44, 95% CI = 1.01-6.00) and diabetes (OR = 6.91, 95% CI = 1.44-37.05) in the risk of RCC. In conclusion, the results of our study suggested an association between the IL-16 rs4778889 polymorphism and an elevated risk of RCC.
authors.affiliation: Department of Urology, Zhejiang Cancer Hospital Hangzhou 310022, Zhejiang, China.
authors.forename: Zongping
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Urology, Zhejiang Cancer Hospital Hangzhou 310022, Zhejiang, China.
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Urology, Zhejiang Cancer Hospital Hangzhou 310022, Zhejiang, China.
authors.forename: Shaoxing
authors.initials: S
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D019410:Interleukin-16
keywords: Interleukin-16; polymorphism; renal cell cancer
references.citation: J Biol Regul Homeost Agents. 2006 Jan-Jun;20(1-2):10-4
references.pmid: 18088549
references.citation: J Natl Cancer Inst. 2004 Jan 21;96(2):99-106
references.pmid: 14734699
references.citation: Biomarkers. 2015;20(3):202-5
references.pmid: 26161702
references.citation: Diabetes Care. 1994 Feb;17(2):115-9
references.pmid: 7907975
references.citation: Proc Natl Acad Sci U S A. 1994 May 24;91(11):5109-13
references.pmid: 7910967
references.citation: Anticancer Res. 2005 Mar-Apr;25(2A):709-13
references.pmid: 15868900
references.citation: Iran J Allergy Asthma Immunol. 2007 Mar;6(1):9-14
references.pmid: 17303923
references.citation: J Exp Clin Cancer Res. 2006 Dec;25(4):529-36
references.pmid: 17310844
references.citation: Lik Sprava. 2007 Jul-Sep;(5-6):46-9
references.pmid: 18416164
references.citation: Am J Epidemiol. 2008 Aug 1;168(3):268-77
references.pmid: 18544571
references.citation: Carcinogenesis. 2009 Feb;30(2):295-9
references.pmid: 19073878
references.citation: Clin Chim Acta. 2009 Nov;409(1-2):132-5
references.pmid: 19758567
references.citation: Int J Urol. 2010 Aug;17(8):700-7
references.pmid: 20529140
references.citation: Infect Genet Evol. 2011 Dec;11(8):2083-8
references.pmid: 22019522
references.citation: J Gastrointestin Liver Dis. 2011 Dec;20(4):371-6
references.pmid: 22187702
references.citation: Ann Oncol. 2012 Sep;23(9):2235-44
references.pmid: 22398178
references.citation: Mediators Inflamm. 2013;2013:564750
references.pmid: 24288444
references.citation: Genet Test Mol Biomarkers. 2014 Mar;18(3):174-82
references.pmid: 24328527
references.citation: Tumour Biol. 2014 Mar;35(3):1917-24
references.pmid: 24101193
references.citation: Jpn J Clin Oncol. 2015 Feb;45(2):202-9
references.pmid: 25420690
references.citation: Int J Clin Exp Pathol. 2015;8(2):1594-603
references.pmid: 25973044
references.citation: PLoS One. 2015;10(6):e0130980
references.pmid: 26114873
references.citation: J Allergy Clin Immunol. 2003 Dec;112(6):1191-4
references.pmid: 14657881