title: Extrathyroidal Calcitonin Secreting Tumors: Pancreatic Neuroendocrine Tumors in Patients With Multinodular Goiter: Two Case Reports.
abstract: Calcitonin is the hallmark of medullary thyroid carcinoma. However, extrathyroidal neuroendocrine tumors can also release calcitonin.We report 2 cases of calcitonin-secreting pancreatic tumors found in asymptomatic patients with thyroid nodules referred to our center within 11 months.Case 1: A man initially referred for thyroid nodule characterization was found to have hypercalcitoninemia (>200 pg/mL) during non-neoplastic fine-needle aspiration.Case 2: A woman evaluated for liver metastasis was found to have hypercalcitoninemia and multinodular goiter.Our research emphasizes that marked hypercalcitoninemia in the presence of thyroid nodules is not necessarily due to medullary thyroid carcinoma; awareness of this could avoid unnecessary thyroidectomy. The lack of specific symptoms related to hypercalcitoninemia may be the reason that the prevalence of calcitonin-secreting pancreatic tumors is underestimated.
authors.affiliation: From the Department of Experimental Medicine, Sapienza University of Rome, Rome (EG, DG, CP, RL, CG, ES, AL, AMI); Nuclear Medicine Unit, Department of Interventional Oncology, Azienda Ospedaliera-Ospedale di Circolo di Busto Arsizio, Varese (AB); and Department of Surgical Science, Sapienza University of Rome, Rome, Italy (RC, PC).
authors.forename: Elisa
authors.initials: E
authors.lastname: Giannetta
authors.forename: Daniele
authors.initials: D
authors.lastname: Gianfrilli
authors.forename: Carlotta
authors.initials: C
authors.lastname: Pozza
authors.forename: Rosa
authors.initials: R
authors.lastname: Lauretta
authors.forename: Chiara
authors.initials: C
authors.lastname: Graziadio
authors.forename: Emilia
authors.initials: E
authors.lastname: Sbardella
authors.forename: Alberto
authors.initials: A
authors.lastname: Baroli
authors.forename: Roberto
authors.initials: R
authors.lastname: Caronna
authors.forename: Piero
authors.initials: P
authors.lastname: Chirletti
authors.forename: Andrea
authors.initials: A
authors.lastname: Lenzi
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Isidori
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D002116:Calcitonin / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006044:Goiter, Nodular / Q000097:blood / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000097:blood / Q000175:diagnosis*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D002116:Calcitonin
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