title: Relevance of a 5-grass sublingual tablet for immunotherapy of patients with grass pollen allergy in North America.
abstract: Grass pollen allergy is common and clinically consequential in North America. While it is frequently treated with subcutaneous or sublingual immunotherapy, debate remains regarding whether allergen immunotherapy is best carried out using a single representative or multiple cross-reactive allergen(s). Patients are commonly exposed to pollens from multiple allergenic grass species belonging to the Pooideæ subfamily. Beyond the known IgE cross-reactivity, considerable molecular heterogeneity exists with respect to allergen content among grass species, with further evidence that these molecular variants can be detected by the patients' immune system. These observations provide a compelling scientific rationale for the use of mixed pollen allergen extracts to broaden the allergen repertoire, with the aim of reorienting inappropriate immune responses in allergic patients.
authors.affiliation: a Research Department , Stallergenes Greer , Antony , France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Moingeon
authors.affiliation: b University of Miami School of Medicine , Miami , FL , USA.|c Nova Southeastern University School of Osteopathic Medicine , Fort Lauderdale , FL , USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Cox
mesh_terms: D000485:Allergens / Q000276:immunology*; D000068456:Clinical Studies as Topic; D003429:Cross Reactions; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D009656:North America / Q000453:epidemiology; D006109:Poaceae / Q000276:immunology; D011058:Pollen / Q000276:immunology*; D015995:Prevalence; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology / Q000276:immunology / Q000628:therapy*; D063729:Sublingual Immunotherapy / Q000379:methods*; D013607:Tablets / Q000008:administration & dosage
chemical_list: D000485:Allergens; D013607:Tablets; D007073:Immunoglobulin E
keywords: Allergens; Pooideæ; allergen immunotherapy; grass pollen; sublingual