title: Effects of electroacupuncture on cognitive function in rats with Parkinson's disease.
abstract: This study was designed to illustrate the effects of electroacupuncture on cognitive function in rats with Parkinson's disease (PD). The PD model was established by injecting 6-OHDA into the rat brain. Rats with PD were then subjected to electroacupuncture and levodopa treatment for 2 weeks. The level of choline acetyltransferase (ChAT) activity in rat brain homogenates was assessed, for the cerebral cholinergic system is a major chemical pathway consisting of cognitive functions. Immunohistochemistry was applied to observe ChAT expression in the rat hippocampus and corpus striatum. The effects of electroacupuncture on cognitive function were comprehensively assessed in PD rats using Y-maze test. Compared with model control group, electroacupuncture group were apparently improved in learning & memory abilities, and ChAT activity was elevated, and apoptosis was reduced in the rat hippocampus and corpus striatum. No significant differences in learning & memory abilities and ChAT activity were detected between electroacupuncture and levodopa groups. Electroacupuncture remarkably improved cognition in PD rats, and its mechanisms are possibly associated with protecting cholinergic neurons in the central nervous system and elevating ChAT activity, and also might suitable dosage of levodopa protect physiologically the cognitive function in PD rats.
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao-Tong University School of Medicine Shanghai, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao-Tong University School of Medicine Shanghai, China.
authors.forename: Yan-Ying
authors.initials: YY
authors.lastname: Xie
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao-Tong University School of Medicine Shanghai, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao-Tong University School of Medicine Shanghai, China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Wang
keywords: Electroacupuncture; Parkinson’s disease; Y-maze; choline acetyltransferase; cognitive function
references.citation: Dement Geriatr Cogn Disord. 2012;33(1):59-72
references.pmid: 22415211
references.citation: Acupunct Med. 2013 Jun;31(2):235-8
references.pmid: 23470639
references.citation: Brain. 2007 Jul;130(Pt 7):1787-98
references.pmid: 17535834
references.citation: Lancet Neurol. 2003 Apr;2(4):229-37
references.pmid: 12849211
references.citation: Int J Physiol Pathophysiol Pharmacol. 2014 Oct 11;6(3):137-42
references.pmid: 25349636
references.citation: Oxid Med Cell Longev. 2015;2015:618631
references.pmid: 26146528
references.citation: Neurosci Bull. 2014 Feb;30(1):153-61
references.pmid: 24338433
references.citation: N Engl J Med. 2012 Feb 9;366(6):511-9
references.pmid: 22316445
references.citation: Neurology. 1992 Jun;42(6):1142-6
references.pmid: 1603339
references.citation: Chin J Integr Med. 2011 Apr;17(4):267-71
references.pmid: 21509669
references.citation: Exp Neurol. 2008 Jan;209(1):114-24
references.pmid: 17950278
references.citation: J Altern Complement Med. 2008 Jul;14(6):663-71
references.pmid: 18684073
references.citation: Neurosci Lett. 2009 Jan 16;449(3):161-3
references.pmid: 18996168
references.citation: Curr Neurol Neurosci Rep. 2014 Jun;14(6):451
references.pmid: 24760476
references.citation: Neurology. 2005 Jan 25;64(2):224-9
references.pmid: 15668417