title: [Mid-gestational glucose levels and newborn birth weight: birth cohort study].
abstract: OBJECTIVE
  To understand the association between the blood glucose levels of pregnant women in second trimester detected by 75 gram oral glucose tolerance test (OGTT) and the birth weight of neonates.
  
  
  METHODS
  Demographic information collection and OGTT were conducted for 3 081 pregnant women at ≤14 gestational weeks and 24-28 gestational weeks respectively. Multiple logistic regression analysis was done to identify the factors associated with the birth weight and the risks of large for gestational age (LGA) in three levels (FPG, OGTT-1 h and OGTT-2 h) of OGTT percentile group, multiple linear regression analysis was used to evaluate the relationships between maternal glucose levels and neonate birth weight.
  
  
  RESULTS
  Pre-pregnancy obesity (24.0 kg/m2≤BMI<28.0 kg/m2) (OR=1.4, 95%CI:1.0-2.0, P=0.029) and gestational diabetes mellitus (OR=2.4,95% CI: 1.8-3.2, P<0.001) were the risk factors. Pre-pregnancy underweight (BMI<18.5 kg/m2) (OR=1.6, 95%CI: 1.2-2.2, P=0.003), preeclampsia (OR=4.0, 95%CI: 1.9-8.4, P<0.001) increased the risk for small for gestational age (SGA). Multiple linear regression analysis showed neonate birth weight was positive correlated with maternal glucose levels (β were 91.99, 33.60, 32.00, respectively, P<0.001). Percentile groups of each OGTT level was linearly positive associated with increased mean value of neonate birth weight, and so with the risk of LGA.
  
  
  CONCLUSIONS
  There were positive correlations between maternal glucose levels and neonate birth weight. The risk of LGA increased with the maternal glucose levels, but there was no statistical association between SGA and maternal glucose levels. FPG level is one of the predictors of LGA. Active surveillance and control of maternal glucose level can effectively reduce the risk of LGA.
authors.affiliation: Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Laboratory for Population Health and Eugenics, Hefei 230032, China.
authors.forename: Sanhuan
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Administration, Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, China.
authors.forename: Yeqing
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Obstetrics and Gynecology, Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, China.
authors.forename: Maolin
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Laboratory for Population Health and Eugenics, Hefei 230032, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
authors.affiliation: Department of Obstetrics and Gynecology, Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Pan
authors.affiliation: Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Laboratory for Population Health and Eugenics, Hefei 230032, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Ge
authors.affiliation: Department of Health Care, Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, China.
authors.forename: Shuangqin
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Laboratory for Population Health and Eugenics, Hefei 230032, China.
authors.forename: Leijing
authors.initials: L
authors.lastname: Mao
authors.affiliation: Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Laboratory for Population Health and Eugenics, Hefei 230032, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Laboratory for Population Health and Eugenics, Hefei 230032, China.
authors.forename: Shilu
authors.initials: S
authors.lastname: Tong
authors.affiliation: Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Laboratory for Population Health and Eugenics, Hefei 230032, China.
authors.forename: Fangbiao
authors.initials: F
authors.lastname: Tao
mesh_terms: D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis*; D015331:Cohort Studies; D016640:Diabetes, Gestational; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D016015:Logistic Models; D009765:Obesity; D011225:Pre-Eclampsia; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood*; D012307:Risk Factors; D013851:Thinness
chemical_list: D001786:Blood Glucose