title: Humoral Fingerprinting of Immune Responses: 'Super-Resolution', High-Dimensional Serology.
abstract: In a recent study, Chung et al. report the development of a high-dimensional approach to assess humoral responses to immune perturbation that goes beyond antibody neutralization and titers. This approach enables the identification of potentially novel correlates and mechanisms of protective immunity to HIV vaccination, thus offering a glimpse of how dense phenotyping of serological responses coupled with bioinformatics analysis could lead to much-sought-after markers of protective vaccination responses.
authors.affiliation: Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Lau
authors.affiliation: Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: john.tsang@nih.gov.
authors.forename: John S
authors.initials: JS
authors.lastname: Tsang
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D000914:Antibodies, Viral; D007074:Immunoglobulin G
references.citation: Clin Infect Dis. 2008 Aug 1;47(3):401-9
references.pmid: 18558875
references.citation: Nat Rev Rheumatol. 2015 Mar;11(3):171-82
references.pmid: 25536486
references.citation: Cell. 2014 Apr 10;157(2):499-513
references.pmid: 24725414
references.citation: Cell. 2015 Nov 5;163(4):988-98
references.pmid: 26544943
references.citation: Mol Syst Biol. 2013 Apr 16;9:659
references.pmid: 23591775
references.citation: Trends Genet. 2010 Jul;26(7):326-33
references.pmid: 20570387
references.citation: Nat Rev Immunol. 2002 Aug;2(8):580-92
references.pmid: 12154377
references.citation: Mol Syst Biol. 2012 Jan 17;8:565
references.pmid: 22252388
references.citation: Trends Immunol. 2015 Aug;36(8):479-93
references.pmid: 26187853