title: Extramedullary Breast Relapse of Acute Lymphoblastic Leukemia Controlled with a Second Allogeneic/Autologous Hematopoietic Cell Transplant.
abstract: Relapse of acute lymphoblastic leukemia (ALL) in the breast is uncommon and often precedes systemic relapse, resulting in poor survival. We report the development of breast involvement of ALL in a 20-year-old woman 32 months after a related allogeneic peripheral blood hematopoietic cell transplantation (PBHCT) in first remission. This extramedullary relapse occurred in the continuous presence of complete donor chimerism. After systemic re-induction chemotherapy and a second PBHCT using donor cells that had been cryopreserved at first transplant, our patient has remained in second complete remission for more than 44 months.
authors.affiliation: 1 Department of Pediatrics, University of Arizona , Tucson, Arizona.
authors.forename: Amy B
authors.initials: AB
authors.lastname: Houghtelin
authors.affiliation: 2 Division of Hematology/Oncology/BMT, Department of Pediatrics, University of Arizona , Tucson, Arizona.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Kopp
authors.affiliation: 3 University of Arizona Medical Center; Tucson , Arizona.
authors.forename: Luz
authors.initials: L
authors.lastname: Pelayo-Katsanis
authors.affiliation: 4 Department of Medical Imaging, University of Arizona , Tucson, Arizona.
authors.forename: Philip H
authors.initials: PH
authors.lastname: Kuo
authors.affiliation: 5 Division of Hematology/Oncology, Department of Medicine, University of Arizona , Tucson, Arizona.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Yeager
authors.affiliation: 2 Division of Hematology/Oncology/BMT, Department of Pediatrics, University of Arizona , Tucson, Arizona.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Katsanis
mesh_terms: D000328:Adult; D064592:Autografts; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D016879:Salvage Therapy; D014184:Transplantation, Homologous; D055815:Young Adult
keywords: acute lymphoblastic leukemia; allogeneic peripheral blood stem cell transplant; extramedullary breast relapse; graft-versus-host disease