title: [MALIGNANT MELANOMA--THE INFLUENCE OF HORMONAL FACTORS ON THE PROGRESSION AND PROGNOSIS. COMPARATIVE ANALYSIS BASED ON TWO CLINICAL CASES].
abstract: Malignant melanoma is the most aggressive form of skin cancer showing extremely high metastatic rate and leading to high levels of lethality. The continually growing incidence of malignant melanoma in the world and his difficult early diagnosis are the occasion for numerous studies. The individual risk for malignant transformation of melanocytes is determined by a number of etiologic factors--endogenous and exogenous. Ultraviolet radiation has a leading role in the group of exogenous factors. Within the group of endogenous factors, besides the well-known photo type skin, as well as genes mutations, are added and the sex hormones, with their significant prognostic importance. The differences, which are observed in the progression and prognosis of malignant melanoma in pre- and postmenopausal women, and men, have defined this cutaneous neoplasma as hormone-dependent tumor. We present two seemingly similar clinical cases of 52 year old woman and 53-year-old man diagnosed with malignant melanomas, developed on the basis of pigmented lesions located on the upper back, as we attempt a comparative analysis on etiopathogenetic factors led to radically different course and prognosis of the disease in these two patients.
authors.forename: E
authors.initials: E
authors.lastname: Trayanova
authors.forename: I
authors.initials: I
authors.lastname: Trayanov
authors.forename: A
authors.initials: A
authors.lastname: Chokoeva
authors.forename: G
authors.initials: G
authors.lastname: Tchernev
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D011379:Prognosis; D012307:Risk Factors; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D014466:Ultraviolet Rays