title: Parvovirus leading to thrombotic microangiopathy in a healthy adult.
abstract: A healthy 47-year-old man initially presented with symptoms of body rash, myalgias, dark urine, nausea and vomiting. Acute kidney injury, and positive urine analysis for blood and protein warranted a kidney biopsy, which revealed micro thrombi in kidney vasculature, suggestive of thrombotic microangiopathy. Serology revealed positive parvovirus B19 IgM antibodies and biopsy tests revealed a viral genome on PCR. Despite plasma exchanges and treatment with rituximab, renal function continued to deteriorate to end-stage renal disease.
authors.affiliation: Department of Nephrology, Regina Qu'Appelle Health Region, Regina, Saskatchewan, Canada University of Saskatchewan, Regina, Saskatchewan, Canada.
authors.forename: Bhanu
authors.initials: B
authors.lastname: Prasad
authors.affiliation: Research and Performance Support, Regina Qu'Appelle Health Region, Regina, Saskatchewan, Canada.
authors.forename: Jennifer
authors.initials: J
authors.lastname: St Onge
mesh_terms: D016679:Genome, Viral; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007668:Kidney / Q000098:blood supply / Q000473:pathology / Q000821:virology*; D007676:Kidney Failure, Chronic / Q000209:etiology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications* / Q000628:therapy / Q000821:virology; D016732:Parvovirus B19, Human; D010951:Plasma Exchange; D016133:Polymerase Chain Reaction; D013927:Thrombosis / Q000209:etiology / Q000628:therapy / Q000821:virology*; D057049:Thrombotic Microangiopathies / Q000209:etiology / Q000628:therapy / Q000821:virology*
chemical_list: D007075:Immunoglobulin M
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