title: Diagnostic Performance of Xpert MTB/RIF in Tuberculous Pleural Effusion: Systematic Review and Meta-analysis.
abstract: A systematic review investigating the role of Xpert MTB/RIF in the diagnosis of tuberculous pleural effusion (TPE) was conducted. The pooled sensitivities and specificities of Xpert MTB/RIF were 51.4% and 98.6%, respectively, with culture used as a reference standard and 22.7% and 99.8%, respectively, with a composite reference standard (CRS) used as the benchmark. Xpert MTB/RIF has low sensitivity but excellent specificity in the diagnosis of TPE.
authors.affiliation: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Inderpaul Singh
authors.initials: IS
authors.lastname: Sehgal
authors.affiliation: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Sahajal
authors.initials: S
authors.lastname: Dhooria
authors.affiliation: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Ashutosh Nath
authors.initials: AN
authors.lastname: Aggarwal
authors.affiliation: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Digambar
authors.initials: D
authors.lastname: Behera
authors.affiliation: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India agarwal.ritesh@outlook.in.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Agarwal
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification*; D010996:Pleural Effusion / Q000382:microbiology*; D012293:Rifampin / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis; D014396:Tuberculosis, Pleural / Q000175:diagnosis*
chemical_list: D000995:Antitubercular Agents; D012293:Rifampin
references.citation: Sci Rep. 2014;4:5658
references.pmid: 25014250
references.citation: PLoS One. 2014;9(7):e102702
references.pmid: 25051491
references.citation: J Clin Microbiol. 2015 Aug;53(8):2451-9
references.pmid: 25994163
references.citation: J Clin Microbiol. 2011 Jul;49(7):2540-5
references.pmid: 21593262
references.citation: BMC Pulm Med. 2014;14:58
references.pmid: 24708530
references.citation: Int J Tuberc Lung Dis. 2011 Apr;15(4):553-5
references.pmid: 21396219
references.citation: J Clin Microbiol. 2011 May;49(5):1772-6
references.pmid: 21411592
references.citation: Respir Med. 2008 May;102(5):744-54
references.pmid: 18222681
references.citation: J Clin Microbiol. 2011 Dec;49(12):4138-41
references.pmid: 21956978
references.citation: Ann Intern Med. 2008 Dec 16;149(12):889-97
references.pmid: 19075208
references.citation: J Clin Microbiol. 2014 Jun;52(6):1818-23
references.pmid: 24622091
references.citation: Cochrane Database Syst Rev. 2014;(1):CD009593
references.pmid: 24448973
references.citation: Pneumonol Alergol Pol. 2012;80(1):6-12
references.pmid: 22187175
references.citation: Respir Med. 2014 Jun;108(6):918-23
references.pmid: 24803060
references.citation: Eur Respir J. 2003 Oct;22(4):589-91
references.pmid: 14582908
references.citation: Int J Tuberc Lung Dis. 2011 Sep;15(9):1274-5
references.pmid: 21943862
references.citation: Int J Tuberc Lung Dis. 2015 Feb;19(2):144-50
references.pmid: 25574911
references.citation: Eur Respir J. 2012 Aug;40(2):442-7
references.pmid: 22241741
references.citation: J Clin Microbiol. 2011 Apr;49(4):1202-5
references.pmid: 21270230
references.citation: J Clin Microbiol. 2011 Aug;49(8):3065-7
references.pmid: 21653775
references.citation: J Bronchology Interv Pulmonol. 2015 Apr;22(2):121-9
references.pmid: 25887007
references.citation: Int J Tuberc Lung Dis. 2013 Sep;17(9):1217-9
references.pmid: 23827859
references.citation: J Clin Microbiol. 2012 Feb;50(2):513-5
references.pmid: 22162564
references.citation: Eur Respir J. 2013 Nov;42(5):1427-9
references.pmid: 23900990
references.citation: J Clin Microbiol. 2011 Dec;49(12):4341-2
references.pmid: 21998430
references.citation: Eur Respir J. 2014 Oct;44(4):1090-3
references.pmid: 25063241
references.citation: Thorax. 2010 Aug;65 Suppl 2:ii54-60
references.pmid: 20696694
references.citation: J Res Med Sci. 2015 Jan;20(1):26-31
references.pmid: 25767518
references.citation: Eur Respir J. 2014 Aug;44(2):435-46
references.pmid: 24696113
references.citation: Int J Mycobacteriol. 2013 Sep;2(3):179-82
references.pmid: 26785988
references.citation: Saudi Med J. 2012 Oct;33(10):1100-5
references.pmid: 23047207
references.citation: Respir Care. 2014 May;59(5):756-64
references.pmid: 24106326
references.citation: J Clin Microbiol. 2015 Nov;53(11):3636-8
references.pmid: 26311855