title: Impact of men's dairy intake on assisted reproductive technology outcomes among couples attending a fertility clinic.
abstract: Intake of full-fat dairy has been linked to lower semen quality but whether this leads to decreased fertility is unknown. To address this question, we prospectively evaluated the association of men's dairy intake with treatment outcomes of subfertile couples undergoing assisted reproductive technology (ART). We followed 142 men from couples undergoing infertility treatment with ART at an academic fertility centre between 2007 and 2014. Couples completed dietary assessments prior to treatment, and the female partners underwent a total of 248 ART cycles. Multivariable generalized linear mixed models were used to examine the association of dairy intake with fertilization, implantation, clinical pregnancy and live birth rates adjusting for age, body mass index, smoking status, total exercise time, dietary patterns, alcohol, caffeine, total energy intake, and female dairy intake. Intake of dairy foods, regardless of their fat content, was not associated with fertilization, implantation, clinical pregnancy or live birth rates. The adjusted live birth rates (95% confidence interval) for couples in increasing quartiles of men's dairy intake were 0.42 (0.25, 0.60), 0.25 (0.13, 0.42), 0.26 (0.15, 0.41), and 0.44 (0.27, 0.63) (p linear trend = 0.73). Results remained similar after adjustment for female partner intake of dairy foods. Overall, men's dairy intake was not associated with treatment outcomes of couples undergoing ART.
authors.affiliation: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.|Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.|Reproductive Medicine Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.affiliation: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Yu-Han
authors.initials: YH
authors.lastname: Chiu
authors.affiliation: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Myriam C
authors.initials: MC
authors.lastname: Afeiche
authors.affiliation: Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA, USA.|Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Paige L
authors.initials: PL
authors.lastname: Williams
authors.affiliation: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: Ford
authors.affiliation: Department of Urology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Tanrikut
authors.affiliation: Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Irene
authors.initials: I
authors.lastname: Souter
authors.affiliation: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.|Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA, USA.|Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
authors.affiliation: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.|Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA, USA.|Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Chavarro
mesh_terms: D000293:Adolescent; D000328:Adult; D001723:Birth Rate; D015331:Cohort Studies; D003611:Dairy Products; D004041:Dietary Fats / Q000494:pharmacology; D005260:Female; D005298:Fertility; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted; D055101:Semen Analysis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004041:Dietary Fats
keywords: assisted reproductive technology; cohort studies; dairy intake; infertility; men
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