title: Gender differences in developmental programming of cardiovascular diseases.
abstract: Hypertension is a risk factor for cardiovascular disease, the leading cause of death worldwide. Although multiple factors contribute to the pathogenesis of hypertension, studies by Dr David Barker reporting an inverse relationship between birth weight and blood pressure led to the hypothesis that slow growth during fetal life increased blood pressure and the risk for cardiovascular disease in later life. It is now recognized that growth during infancy and childhood, in addition to exposure to adverse influences during fetal life, contributes to the developmental programming of increased cardiovascular risk. Numerous epidemiological studies support the link between influences during early life and later cardiovascular health; experimental models provide proof of principle and indicate that numerous mechanisms contribute to the developmental origins of chronic disease. Sex has an impact on the severity of cardiovascular risk in experimental models of developmental insult. Yet, few studies examine the influence of sex on blood pressure and cardiovascular health in low-birth weight men and women. Fewer still assess the impact of ageing on sex differences in programmed cardiovascular risk. Thus, the aim of the present review is to highlight current data about sex differences in the developmental programming of blood pressure and cardiovascular disease.
authors.affiliation: Department of Physiology and Biophysics, Center for Women's Health Research, Center for Developmental Disorders Research, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A.
authors.forename: John Henry
authors.initials: JH
authors.lastname: Dasinger
authors.affiliation: Department of Physiology and Biophysics, Center for Women's Health Research, Center for Developmental Disorders Research, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, U.S.A. balexander@umc.edu.
authors.forename: Barbara T
authors.initials: BT
authors.lastname: Alexander
mesh_terms: D001724:Birth Weight / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D047109:Fetal Development / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000196:embryology / Q000209:etiology* / Q000503:physiopathology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology; D012307:Risk Factors; D012727:Sex Characteristics
keywords: ageing; blood pressure; developmental programming; low birth weight; sex differences
references.citation: BMJ. 1989 Mar 4;298(6673):564-7
references.pmid: 2495113
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R731-5
references.pmid: 16971373
references.citation: Pediatr Res. 2006 Jan;59(1):126-30
references.pmid: 16326991
references.citation: J Hypertens. 1999 Jul;17(7):883-8
references.pmid: 10419060
references.citation: Eur J Epidemiol. 2006;21(1):33-8
references.pmid: 16450204
references.citation: Pediatr Res. 2000 Apr;47(4 Pt 1):457-62
references.pmid: 10759151
references.citation: Hypertension. 2013 Apr;61(4):828-34
references.pmid: 23424240
references.citation: Peptides. 2013 Jun;44:111-9
references.pmid: 23500520
references.citation: Fertil Steril. 2015 Jan;103(1):291-8.e2
references.pmid: 25439841
references.citation: Hypertension. 2003 Feb;41(2):328-34
references.pmid: 12574103
references.citation: Circulation. 2005 Sep 6;112(10):1414-8
references.pmid: 16129799
references.citation: Am J Physiol Renal Physiol. 2008 Jul;295(1):F29-34
references.pmid: 18400872
references.citation: Blood Press Monit. 2006 Feb;11(1):9-15
references.pmid: 16410735
references.citation: Kidney Int. 2001 Jan;59(1):238-45
references.pmid: 11135076
references.citation: Am J Obstet Gynecol. 1980 May 1;137(1):43-7
references.pmid: 7369288
references.citation: J Physiol. 2007 Mar 1;579(Pt 2):503-13
references.pmid: 17204493
references.citation: Hypertension. 1997 Aug;30(2 Pt 1):267-71
references.pmid: 9260991
references.citation: Int J Epidemiol. 2002 Apr;31(2):302-8
references.pmid: 11980784
references.citation: Am J Epidemiol. 2002 Dec 15;156(12):1100-4
references.pmid: 12480654
references.citation: Matern Child Health J. 2014 Apr;18(3):527-33
references.pmid: 23686648
references.citation: Physiol Rep. 2015 Apr;3(4):null
references.pmid: 25902787
references.citation: J Physiol. 2009 Jun 1;587(Pt 11):2635-46
references.pmid: 19359373
references.citation: Pediatr Res. 1998 Sep;44(3):317-22
references.pmid: 9727707
references.citation: Early Hum Dev. 2000 Feb;57(2):137-47
references.pmid: 10735460
references.citation: J Am Coll Nutr. 2003 Jun;22(3):239-46
references.pmid: 12805251
references.citation: Int J Food Sci Nutr. 2000 Jan;51(1):11-7
references.pmid: 10746100
references.citation: Hypertension. 2004 Feb;43(2):203-7
references.pmid: 14676220
references.citation: Placenta. 2010 Mar;31 Suppl:S40-6
references.pmid: 20116093
references.citation: Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R1131-6
references.pmid: 15961538
references.citation: J Dev Orig Health Dis. 2010 Feb;1(1):75-83
references.pmid: 25142934
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R758-63
references.pmid: 16917022
references.citation: Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R930-8
references.pmid: 20053962
references.citation: Circulation. 2002 Mar 5;105(9):1088-92
references.pmid: 11877360
references.citation: Pediatr Res. 2001 Apr;49(4):460-7
references.pmid: 11264427
references.citation: Hypertension. 1992 May;19(5):456-63
references.pmid: 1568764
references.citation: PLoS One. 2010 Dec 13;5(12):e15558
references.pmid: 21179452
references.citation: Cardiovasc Res. 2002 Feb 15;53(3):672-7
references.pmid: 11861038
references.citation: Pediatrics. 2007 Jun;119(6):e1264-70
references.pmid: 17545358
references.citation: Pediatrics. 2010 Dec;126(6):e1507-13
references.pmid: 21078732
references.citation: Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R309-17
references.pmid: 19036827
references.citation: Science. 1978 Oct 27;202(4366):436-8
references.pmid: 705336
references.citation: Kidney Int. 2003 Jun;63(6):2113-22
references.pmid: 12753298
references.citation: Am J Physiol Renal Physiol. 2015 Mar 1;308(5):F411-9
references.pmid: 25537745
references.citation: Kidney Int. 2008 Jul;74(2):187-95
references.pmid: 18432184
references.citation: Circulation. 2007 Jan 16;115(2):213-20
references.pmid: 17179023
references.citation: Lancet. 1986 May 10;1(8489):1077-81
references.pmid: 2871345
references.citation: Hypertension. 2005 Jan;45(1):75-9
references.pmid: 15569858
references.citation: Life Sci. 2012 Apr 20;90(15-16):571-7
references.pmid: 22365957
references.citation: Clin Sci (Lond). 1994 Feb;86(2):217-22; discussion 121
references.pmid: 8143432
references.citation: Proc Biol Sci. 2007 Mar 22;274(1611):819-25
references.pmid: 17251089
references.citation: Climacteric. 2007 Feb;10 Suppl 1:32-41
references.pmid: 17364596
references.citation: PLoS One. 2012;7(4):e33308
references.pmid: 22485140
references.citation: Circulation. 2000 Nov 28;102(22):2739-44
references.pmid: 11094041
references.citation: Am J Epidemiol. 2007 Sep 15;166(6):634-45
references.pmid: 17456478
references.citation: J Pediatr. 2007 Dec;151(6):670-4
references.pmid: 18035150
references.citation: Am J Hypertens. 2010 Apr;23(4):379-86
references.pmid: 20111011
references.citation: Exp Physiol. 2002 Jul;87(4):469-77
references.pmid: 12392111
references.citation: Eur J Prev Cardiol. 2016 Jul;23(10):1018-28
references.pmid: 25952251
references.citation: Hypertension. 2010 Feb;55(2):494-9
references.pmid: 20026758
references.citation: Exp Physiol. 2000 Jan;85(1):79-84
references.pmid: 10662897
references.citation: BMJ. 1988 Jul 9;297(6641):134-5
references.pmid: 3408942
references.citation: Hypertension. 2004 Dec;44(6):838-46
references.pmid: 15520301
references.citation: Hypertension. 2012 Jul;60(1):114-22
references.pmid: 22585945
references.citation: J Pharmacol Exp Ther. 2007 Feb;320(2):654-61
references.pmid: 17068201
references.citation: Hypertension. 2009 Feb;53(2):375-80
references.pmid: 19103999
references.citation: Br J Obstet Gynaecol. 1990 Jan;97(1):11-25
references.pmid: 2137711
references.citation: Hum Reprod. 2010 Mar;25(3):791-8
references.pmid: 20047935
references.citation: Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R121-9
references.pmid: 23174859
references.citation: Am J Hypertens. 1995 Oct;8(10 Pt 1):978-86
references.pmid: 8845079
references.citation: Ann Hum Biol. 2007 Mar-Apr;34(2):252-64
references.pmid: 17558595
references.citation: Hypertension. 2007 Oct;50(4):679-85
references.pmid: 17724277
references.citation: J Pharmacol Exp Ther. 1998 Jun;285(3):931-45
references.pmid: 9618392
references.citation: Lancet. 2002 Aug 31;360(9334):659-65
references.pmid: 12241871
references.citation: BMJ Open. 2015 Jun 23;5(6):e008136
references.pmid: 26105032
references.citation: Tohoku J Exp Med. 2014;234(1):41-50
references.pmid: 25175031
references.citation: Semin Perinatol. 1996 Apr;20(2):115-26
references.pmid: 8857697
references.citation: Reprod Toxicol. 2009 Apr;27(2):149-54
references.pmid: 19429393
references.citation: Hypertens Res. 2013 Aug;36(8):725-35
references.pmid: 23595042
references.citation: Pediatrics. 2011 May;127(5):e1272-9
references.pmid: 21502227
references.citation: Int J Obes (Lond). 2007 Feb;31(2):236-44
references.pmid: 16718281
references.citation: Am J Hypertens. 2011 Jan;24(1):77-82
references.pmid: 20725054
references.citation: J Physiol. 2005 May 15;565(Pt 1):125-35
references.pmid: 15774515
references.citation: Hypertension. 2008 Apr;51(4):1239-47
references.pmid: 18259024
references.citation: Eur J Epidemiol. 2006;21(10):759-65
references.pmid: 17082900
references.citation: Menopause. 2012 Oct;19(10):1081-7
references.pmid: 22692332
references.citation: Hypertension. 2013 Jun;61(6):1246-54
references.pmid: 23529162
references.citation: Hypertension. 2006 Sep;48(3):431-6
references.pmid: 16880348
references.citation: Am J Physiol Regul Integr Comp Physiol. 2010 May;298(5):R1421-7
references.pmid: 20219873
references.citation: Hypertension. 2013 Oct;62(4):753-8
references.pmid: 23940196
references.citation: Circulation. 2007 Feb 6;115(5):e69-171
references.pmid: 17194875
references.citation: Gend Med. 2008;5 Suppl A:S121-32
references.pmid: 18395678
references.citation: Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R360-7
references.pmid: 15528396
references.citation: J Am Soc Nephrol. 2005 Oct;16(10):2913-9
references.pmid: 16093454
references.citation: Am J Obstet Gynecol. 2006 Apr;194(4):921-31
references.pmid: 16580277
references.citation: Pediatr Nephrol. 2001 May;16(5):417-22
references.pmid: 11405116
references.citation: J Biol Chem. 2010 Jun 4;285(23):17271-6
references.pmid: 20348094
references.citation: Dtsch Med Wochenschr. 2000 Nov 24;125(47):1444-9
references.pmid: 11130124
references.citation: Arch Dis Child. 1996 Jun;74(6):538-41
references.pmid: 8758133
references.citation: Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R1111-6
references.pmid: 20106989
references.citation: Pediatr Res. 1998 May;43(5):563-70
references.pmid: 9585000
references.citation: Contraception. 1999 Mar;59(3):203-7
references.pmid: 10382084
references.citation: Hypertension. 2005 Apr;45(4):754-8
references.pmid: 15699462
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R804-11
references.pmid: 17537837
references.citation: BMJ. 1993 Jan 2;306(6869):24-7
references.pmid: 8435572
references.citation: Hypertension. 2003 Mar;41(3):457-62
references.pmid: 12623943
references.citation: Maturitas. 2006 Jan 20;53(2):176-83
references.pmid: 15921866
references.citation: Cardiovasc Res. 1998 Dec;40(3):600-6
references.pmid: 10070502
references.citation: Soc Sci Med. 2015 Sep;141:91-9
references.pmid: 26259011
references.citation: Hypertension. 2001 Sep;38(3):389-93
references.pmid: 11566910