title: Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines.
abstract: A small library of novel 2-oxo-1,2,3,4-tetrahydropyrimidines was synthesized via a one-pot multicomponent Biginelli reaction. Copper complex [Formula: see text] which was used for the first time as a homogeneous and heterogeneous catalyst, makes this a facile and efficient reaction at room temperature. All the obtained products fall out of the solution in pure form and are easily isolated via filtration in good-to-excellent yields. The molecular structure of one of the products, ethyl 6-methyl-2-oxo-4-(4[Formula: see text]-isopropoxy-3[Formula: see text]-methoxyphenyl) - 1,2,3,4 - tetrahydropyrimidine-5- carboxylate, has been determined by X-ray crystallography. All non-hydrogen atoms in the heterocyclic, six-membered ring are determined to be approximately coplanar.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, P.O. Box 60, Kragujevac, 34 000, Serbia.
authors.forename: Jovana
authors.initials: J
authors.lastname: Muškinja
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, P.O. Box 60, Kragujevac, 34 000, Serbia. nenad.jankovic@kg.ac.rs.
authors.forename: Nenad
authors.initials: N
authors.lastname: Janković
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, P.O. Box 60, Kragujevac, 34 000, Serbia.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Ratković
authors.affiliation: Laboratory of Theoretical Physics and Condensed Matter Physics, Faculty of Science, Vinča Institute of Nuclear Science, University of Belgrade, P.O. Box 522, Belgrade, 11001, Serbia.
authors.forename: Goran
authors.initials: G
authors.lastname: Bogdanović
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, P.O. Box 60, Kragujevac, 34 000, Serbia.
authors.forename: Zorica
authors.initials: Z
authors.lastname: Bugarčić
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D014641:Vanillic Acid / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D011743:Pyrimidines; D014641:Vanillic Acid
keywords: Heterocycles; Heterogeneous catalysis; Homogeneous catalysis; Multicomponent reactions (MCRs)
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