title: Metabolic effects of a 13-weeks lifestyle intervention in older adults: The Growing Old Together Study.
abstract: For people in their 40s and 50s, lifestyle programs have been shown to improve metabolic health. For older adults, however, it is not clear whether these programs are equally healthy. In the Growing Old Together study, we applied a 13-weeks lifestyle program, with a target of 12.5% caloric restriction and 12.5% increase in energy expenditure through an increase in physical activity, in 164 older adults (mean age=63.2 years; BMI=23-35 kg/m2). Mean weight loss was 4.2% (SE=2.8%) of baseline weight, which is comparable to a previous study in younger adults. Fasting insulin levels, however, showed a much smaller decrease (0.30 mU/L (SE=3.21)) and a more heterogeneous response (range=2.0-29.6 mU/L). Many other parameters of metabolic health, such as blood pressure, and thyroid, glucose and lipid metabolism improved significantly. Many 1H-NMR metabolites changed in a direction previously associated with a low risk of type 2 diabetes and cardiovascular disease and partially independently of weight loss. In conclusion, 25% reduction in energy balance for 13 weeks induced a metabolic health benefit in older adults, monitored by traditional and novel metabolic markers.
authors.affiliation: Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.
authors.forename: Ondine
authors.initials: O
authors.lastname: van de Rest
authors.affiliation: Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: Bianca A M
authors.initials: BA
authors.lastname: Schutte
authors.affiliation: Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: Joris
authors.initials: J
authors.lastname: Deelen
authors.affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: Stephanie A M
authors.initials: SA
authors.lastname: Stassen
authors.affiliation: Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.|The Delft Bioinformatics Lab, Delft University of Technology, 2628 CD Delft, The Netherlands.
authors.forename: Erik B
authors.initials: EB
authors.lastname: van den Akker
authors.affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: Diana
authors.initials: D
authors.lastname: van Heemst
authors.affiliation: Department of Radiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: Petra
authors.initials: P
authors.lastname: Dibbets-Schneider
authors.affiliation: Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.
authors.forename: Regina A
authors.initials: RA
authors.lastname: van Dipten-van der Veen
authors.affiliation: Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.
authors.forename: Milou
authors.initials: M
authors.lastname: Kelderman
authors.affiliation: Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2300 RA, The Netherlands.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hankemeier
authors.affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: Simon P
authors.initials: SP
authors.lastname: Mooijaart
authors.affiliation: Department of Radiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: van der Grond
authors.affiliation: Department of Medical Statistics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: Jeanine J
authors.initials: JJ
authors.lastname: Houwing-Duistermaat
authors.affiliation: Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: Marian
authors.initials: M
authors.lastname: Beekman
authors.affiliation: Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.
authors.forename: Edith J M
authors.initials: EJ
authors.lastname: Feskens
authors.affiliation: Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: P Eline
authors.initials: PE
authors.lastname: Slagboom
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D031204:Caloric Restriction; D004734:Energy Metabolism; D015444:Exercise; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D009752:Nutritional Status; D066244:Proton Magnetic Resonance Spectroscopy; D012307:Risk Factors; D040242:Risk Reduction Behavior; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D015415:Biomarkers
keywords: caloric restriction; healthy ageing; lifestyle intervention; metabolic health; older adults; physical activity
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