title: Shedding Light on Inherited Thrombophilias: The Impact on Pregnancy.
abstract: Physiologic changes of pregnancy result in a hypercoagulable state, placing the risk for venous thromboembolic events at 1 in 1600 births. Venous thromboembolic events are one of the leading causes of maternal mortality. A correlation among venous thromboembolic events, pregnancy complications, and inherited thrombophilia continues to be investigated. This article primarily focuses on the impact of inherited thrombophilias on pregnancy, labor, and birth and yet also addresses acquired thrombophilia. Prophylactic and therapeutic perinatal anticoagulation are lifesaving and pregnancy-sparing interventions. Interprofessional management of these high-risk pregnancies allows for increased surveillance to reduce perinatal morbidity and mortality.
authors.affiliation: Birthing Center, Washington Hospital Healthcare System, Fremont, California.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Dobbenga-Rhodes
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D018890:Chemoprevention / Q000379:methods; D019468:Disease Management; D005260:Female; D006801:Humans; D008428:Maternal Mortality; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D054556:Venous Thromboembolism / Q000209:etiology / Q000517:prevention & control
chemical_list: D000925:Anticoagulants