title: Anti-ulcer activity of the aqueous extract of Melastoma malabathricum L. leaf in rats.
abstract: Melastoma malabathricum L. Smith (Melastomaceae) has been used in the Malay traditional culture to treat ulcer-based ailments.The objective of the present study was to investigate the potential anti-ulcer effect of aqueous extract of M. malabathricum leaves (AEMM) using ethanol- and indomethacin-induced gastric ulcer models in rats. Rats were divided into ten groups (n=6) and received DMSO (10%; negative group), ranitidine (100mg/kg; positive group) or AEMM (50, 250 and 500mg/kg) orally for 7 days and on the 8(th) day subjected to the respective gastric ulcer models. The stomachs were collected and subjected to macroscopic and microscopic analysis. At all groups tested, the AEMM exerted significant (p<0.05) anti-ulcer effect only against the ethanol-induced gastric ulcer model. The percentage of anti-ulcer for the 50-500mg/kg AEMM ranging between 50-82%, respectively. The macroscopic observations were supported by histological findings. In conclusion, AEMM exhibits potential anti-ulcer activity attributed to its previously proven high flavonoids content and antioxidant activity.
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia.
authors.forename: Wan-Noraziemah
authors.initials: WN
authors.lastname: Wan Zainulddin
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia.
authors.forename: Zalina
authors.initials: Z
authors.lastname: Zabidi
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia.
authors.forename: Farah Hidayah
authors.initials: FH
authors.lastname: Kamisan
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia.
authors.forename: Farhana
authors.initials: F
authors.lastname: Yahya
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia.
authors.forename: Noor Aisyah
authors.initials: NA
authors.lastname: Ismail
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia.
authors.forename: Nor Shafawati
authors.initials: NS
authors.lastname: Nor Shamsahal Din
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia.
authors.forename: Siti Syariah
authors.initials: SS
authors.lastname: Mamat
authors.affiliation: Center for Food Technology Research, Biotechnology Research Centre, Malaysian Agriculture Research Institute, Kuala Lumpur, Malaysia.
authors.forename: Hadijah
authors.initials: H
authors.lastname: Hassan
authors.affiliation: Department of Pathology, Faculty of Medicine and Health Sciences, University Putra Malaysia, Selangor, Malaysia.
authors.forename: Norhafizah
authors.initials: N
authors.lastname: Mohtarrudin
authors.affiliation: Department of Biomedical Sciences, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia.
authors.forename: Zainul Amiruddin
authors.initials: ZA
authors.lastname: Zakaria
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D008297:Male; D035322:Melastomataceae; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts