title: Thyroid side effects prophylaxis in front of nuclear power plant accidents.
abstract: The better knowledge of the mechanisms of nuclear incidents and lessons learned from accidents in the recent past to improve the effectiveness of measures taken following a nuclear accident exposure to fallout of radioactive iodine isotopes. Thus, immediate, passive measures, such as containment, and stopping consumption of contaminated products are paramount. The earliest possible administration of stable iodine as potassium iodide (KI) reduces significantly (up to 90% if taken at the same time of the accident) thyroid radioactive contamination. These tablets should be given in priority to children and pregnant women. The side effects are minor. KI is not recommended for persons aged over 60 years, or for adults suffering from cardiovascular disorders.
authors.affiliation: University of Lorraine, Department of Endocrinology and Medical Gynecology, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France. Electronic address: m.agopiantz@chu-nancy.fr.
authors.forename: Mikaël
authors.initials: M
authors.lastname: Agopiantz
authors.affiliation: University of Lorraine, Department of Pharmacy, 5, rue Albert-Lebrun, 54000 Nancy, France.
authors.forename: Ouifak
authors.initials: O
authors.lastname: Elhanbali
authors.affiliation: University of Lorraine, Department of Pharmacy, 5, rue Albert-Lebrun, 54000 Nancy, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Demore
authors.affiliation: University of Lorraine, Department of Endocrinology and Medical Gynecology, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Cuny
authors.affiliation: University of Lorraine, Department of Endocrinology and Medical Gynecology, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: Léa
authors.initials: L
authors.lastname: Demarquet
authors.affiliation: University of Lorraine, Department of Pharmacy, 5, rue Albert-Lebrun, 54000 Nancy, France.
authors.forename: Cumba
authors.initials: C
authors.lastname: Ndiaye
authors.affiliation: University of Lorraine, Department of Biochemistery, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Barbe
authors.affiliation: University of Lorraine, Department of Endocrine Surgery, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Brunaud
authors.affiliation: University of Lorraine, Department of Endocrinology and Medical Gynecology, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Weryha
authors.affiliation: University of Lorraine, Department of Endocrinology and Medical Gynecology, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Klein
mesh_terms: D047852:Chernobyl Nuclear Accident; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D055848:Nuclear Power Plants; D011193:Potassium Iodide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D011847:Radioactive Fallout / Q000009:adverse effects; D018788:Radioactive Hazard Release; D013959:Thyroid Diseases / Q000209:etiology* / Q000517:prevention & control*; D013964:Thyroid Neoplasms / Q000209:etiology / Q000517:prevention & control
chemical_list: D007457:Iodine Radioisotopes; D011847:Radioactive Fallout; D011193:Potassium Iodide
keywords: Accident nucléaire; Cancer; Iode; Iodine; Nuclear power plant accident; Thyroid; Thyroïde