title: [Survival time and associated factors of 8 310 AIDS patients initially receiving antiretroviral treatment of Liangshan Yi Autonomous Prefecture, Sichuan province of China].
abstract: OBJECTIVE
  To investigate the survival time and its impact factors among AIDS patients who initially received antiretroviral treatment (ART) of Liangshan Yi Autonomous Prefecture, Sichuan province.
  
  
  METHODS
  A retrospective cohort study was conducted to analyze the information of AIDS patients over 18 years old initially received ART in Liangshan Yi Autonomous Prefecture during 2005-2013, which were downloaded from Chinese AIDS Antiretroviral Therapy DATA Fax Information System. Cox proportion hazard regression model was used to identify impact factors related survival time.
  
  
  RESULTS
  Among 8 310 ART AIDS patients who initially received ART, their mean age was (34.59 ± 9.10) years old, 65.50% (5 443 cases) were infected with HIV through injecting drug use, the mean time from testing HIV positive to starting ART were (24.68 ± 21.69) months. 436 cases died of AIDS related diseases, 28.67% (125 cases) of them died within the first 6 months of treatment. The cumulative survival rate of receiving ART in 1, 2, 3, 4 5 years were 97.11%, 93.41%, 90.61%, 88.81%, 86.02%, respectively. Multivariate Cox regression analysis showed the male patients receiveing ART were at a higher risk death of AIDS related diseases compared to the females (HR = 1.57, 95% CI: 1.13-2.182), the patients infected with HIV through injecting drug use were at a higher risk deathcompared to the infected through heterosexual transmission (HR = 1.64, 95% CI: 1.20-2.24), before the treatment patients with tuberculosis in recent1 year had higher death hazard as compared to those without tuberculosis (HR = 1.53, 95% CI: 1.05-2.21), in the treatment of the first 3 months of AIDS related diseases or symptoms of AIDS patients had higher death hazard as compared to those not suffer these diseases (HR = 1.80, 95% CI: 1.39-2.34). The patients with baseline CD4 (+) T lymphocytes cell counts < 50/µl (HR = 9.79, 95% CI: 6.03-15.89), 50-199/µl (HR = 3.26, 95% CI: 2.32-4.59), 200-349/µl (HR = 1.69, 95% CI: 1.22-2.34), were at a higher risk death than those with CD4 (+) T lymphocytes cell counts ≥ 350/µl.
  
  
  CONCLUSIONS
  Accumulate survival rate was higher after initial antiretroviral treatment among AIDS patients in Liangshan Yi Autonomous Prefecture, Sichuan province. AIDS patients who are males, have tuberculosis in recent year, infected HIV via route of intravenous drug use, with AIDS-related illness or symptoms in 3 months before ART, lower baseline CD4 (+) T lymphocyte count have higher risk of death.
authors.affiliation: Exchange and Communication Office of National Center for AIDS/STD Control and Prevention, China Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Division of HIV/AIDS Control and Prevetion, Liangshan Yi Autonomous Prefecture Center for Disease Control and Prevention, Sichuan province, Xichang 615000, China.
authors.forename: Yuhan
authors.initials: Y
authors.lastname: Gong
authors.forename: Qixing
authors.initials: Q
authors.lastname: Wang
authors.forename: Shize
authors.initials: S
authors.lastname: Zhang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liao
authors.forename: Gang
authors.initials: G
authors.lastname: Yu
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Ju
authors.initials: J
authors.lastname: Wang
authors.forename: Shaodong
authors.initials: S
authors.lastname: Ye
authors.affiliation: Email: zhongfuliu@163.com.
authors.forename: Zhongfu
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000401:mortality*; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D044466:Asian People; D002681:China; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D015819:Substance Abuse, Intravenous; D015996:Survival Rate; D014376:Tuberculosis / Q000150:complications
chemical_list: D044966:Anti-Retroviral Agents