title: Editorial on the role of "Genetic mediators of neurocognitive outcome in survivors of childhood acute lymphoblastic leukemia".
abstract: With current chemotherapy regimen favorable event free survival rates can be achieved for children and adolescents with acute lymphoblastic leukemia (ALL). Besides others, neurocognitive late effects come more and more into the focus of attention. Especially, as first reports indicate that the omission of cranial irradiation (CRT) did not solve the problem of neurocognitive deficits. The report by Krull and colleagues analyzed the association of neurocognitive outcome and a large set of potentially predisspoing polymorphisms. The authors identified significant associations between specific polymorphisms and neurocognitive outcome. However, the consequences of such testing need to be discussed carefully.
authors.affiliation: University Hospital Muenster, Pediatric Hematology and Oncology, Muenster, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Burkhardt
keywords: Acute lymphoblastic leukemia (ALL); neurocognitive outcome; predisposing polymorphisms
references.citation: JAMA. 2007 Jun 27;297(24):2705-15
references.pmid: 17595271
references.citation: Blood. 2013 Jun 27;121(26):5145-53
references.pmid: 23652803
references.citation: J Clin Oncol. 2013 Jun 10;31(17):2182-8
references.pmid: 23650422
references.citation: J Pediatr Hematol Oncol. 2011 Aug;33(6):450-8
references.pmid: 21646917
references.citation: J Natl Cancer Inst. 2012 Sep 19;104(18):1386-95
references.pmid: 22927505
references.citation: J Clin Oncol. 2008 Oct 1;26(28):4639-45
references.pmid: 18824710
references.citation: Blood. 2013 Jul 25;122(4):550-3
references.pmid: 23744583
references.citation: Horm Res Paediatr. 2013;79(1):9-16
references.pmid: 23306635
references.citation: N Engl J Med. 2006 Oct 12;355(15):1572-82
references.pmid: 17035650
references.citation: Blood. 2008 Jun 15;111(12):5515-23
references.pmid: 18334672
references.citation: JAMA. 2007 Mar 21;297(11):1207-15
references.pmid: 17374815
references.citation: N Engl J Med. 2009 Jun 25;360(26):2730-41
references.pmid: 19553647
references.citation: J Clin Oncol. 2008 Jun 20;26(18):3038-45
references.pmid: 18565890
references.citation: Blood. 2000 May 1;95(9):2770-5
references.pmid: 10779419
references.citation: J Clin Oncol. 2007 Apr 20;25(12):1525-31
references.pmid: 17442995
references.citation: Pediatr Blood Cancer. 2012 Aug;59(2):278-84
references.pmid: 21938763