title: Dietary folate, one-carbon metabolism-related genes, and gastric cancer risk in Korea.
abstract: METHODS
  We evaluated the interactions between polymorphisms involved in one-carbon metabolism-related genes and dietary folate intake in gastric cancer risk within the Korean population through a hospital-based case-control study.
  
  
  RESULTS
  A total of 542 controls and 271 cases were included. Genotype data were selected from data produced by the Affymetrix Axiom(®) Exome 319 Array. We considered seven single nucleotide polymorphisms (SNPs) of five genes whose SNPs are located in the coding region with a minor allele frequency > 5%: MTHFR (G1793A, A1298C, C677T), MTR A2756G, MTRR A66G, SHMT1 C1420T, and SLC19A1 G80A. Our study found that MTR A2756G was associated with a decreased gastric cancer risk. MTHFR G1793A showed a statistically significant interaction between dietary folate intake and gastric cancer.
  
  
  CONCLUSIONS
  Our results suggest that MTR A2756G is significantly associated with gastric cancer risk, and that MTHFR G1793A statistically interacts with dietary folate intake. Our findings indicate that gene-folate interactions may contribute to gastric cancer risk.
authors.affiliation: Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Goyang, Korea.
authors.forename: Woori
authors.initials: W
authors.lastname: Kim
authors.affiliation: Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Goyang, Korea.
authors.forename: Hae Dong
authors.initials: HD
authors.lastname: Woo
authors.affiliation: Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Goyang, Korea.
authors.forename: Jeonghee
authors.initials: J
authors.lastname: Lee
authors.affiliation: Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Korea.
authors.forename: Il Ju
authors.initials: IJ
authors.lastname: Choi
authors.affiliation: Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Korea.
authors.forename: Young Woo
authors.initials: YW
authors.lastname: Kim
authors.affiliation: Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea.
authors.forename: Joohon
authors.initials: J
authors.lastname: Sung
authors.affiliation: Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Goyang, Korea.
authors.forename: Jeongseon
authors.initials: J
authors.lastname: Kim
mesh_terms: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002244:Carbon / Q000378:metabolism*; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics; D005492:Folic Acid / Q000494:pharmacology*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D012696:Glycine Hydroxymethyltransferase / Q000235:genetics; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D058978:Reduced Folate Carrier Protein / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics* / Q000517:prevention & control
chemical_list: D058978:Reduced Folate Carrier Protein; C548699:SLC19A1 protein, human; D002244:Carbon; D005492:Folic Acid; C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; C585801:MTR protein, human; D012696:Glycine Hydroxymethyltransferase; C520541:SHMT protein, human
keywords: Effect modification; Folate; Gastric cancer; Interaction; One-carbon metabolism