title: Association of RNF43 with cell cycle proteins involved in p53 pathway.
abstract: Our previous study has demonstrated that RNF43 could regulate the cell cycle in a p53-dependent manner in HCC. In this study, we aimed to access whether RNF43 could interact with cell cycle proteins involved in p53 pathway, including pRB, Cyclin D1 and MDM2. Totally, 123 paired HCC tissues and corresponding noncancerous tissues from HCC patients were included, and the expression of Cyclin D1, pRB and MDM2 was analyzed using tissue microarray. Our results showed the expression level of RNF43 in HCC was positively correlated with that of MDM2, Cyclin D1 and pRB-S780. There was no significant correlation between the expression of RNF43 and pRB-S807/S811. Indicating that RNF43 effected cell cycling by regulating the expression of pRB, Cyclin D1 and MDM2 proteins, and pRB-S780 but not pRB-S807/S811, was participated in RNF43 regulated cell cycling.
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Xie
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
authors.forename: Chunyang
authors.initials: C
authors.lastname: Xing
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Cao
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health Hangzhou, China.
authors.forename: Bajin
authors.initials: B
authors.lastname: Wei
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xu
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
authors.forename: Penghong
authors.initials: P
authors.lastname: Song
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
authors.forename: Leiming
authors.initials: L
authors.lastname: Chen
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Chen
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
authors.forename: Shengyong
authors.initials: S
authors.lastname: Yin
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
authors.forename: Shusen
authors.initials: S
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015513:Oncogene Proteins / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D015513:Oncogene Proteins; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C496945:RNF43 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: HCC; RNF43; cell cycling; p53; tissue microarray
references.citation: Semin Cancer Biol. 2003 Feb;13(1):49-58
references.pmid: 12507556
references.citation: Mol Cell Biol. 2003 Jul;23(13):4713-27
references.pmid: 12808109
references.citation: Curr Biol. 2004 Sep 21;14(18):R787-96
references.pmid: 15380093
references.citation: Science. 1990 Nov 30;250(4985):1233-8
references.pmid: 1978757
references.citation: Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5545-9
references.pmid: 7777546
references.citation: EMBO J. 1996 Dec 16;15(24):7060-9
references.pmid: 9003781
references.citation: Exp Biol Med (Maywood). 2006 Jul;231(7):1271-81
references.pmid: 16816134
references.citation: Nat Rev Mol Cell Biol. 2008 May;9(5):402-12
references.pmid: 18431400
references.citation: Cell Cycle. 2008 Apr 1;7(7):842-7
references.pmid: 18414039
references.citation: Biochem Biophys Res Commun. 2010 May 21;396(1):85-9
references.pmid: 20494116
references.citation: Biochem Biophys Res Commun. 2011 Jan 7;404(1):143-7
references.pmid: 21108931
references.citation: EMBO J. 2011 Jan 19;30(2):317-27
references.pmid: 21119616
references.citation: Hepatology. 2011 Mar;53(3):1020-2
references.pmid: 21374666
references.citation: Nat Rev Cancer. 2011 Aug;11(8):558-72
references.pmid: 21734724
references.citation: Carcinogenesis. 2012 Jan;33(1):220-5
references.pmid: 22072615
references.citation: Cancer Biol Ther. 2012 May;13(7):451-7
references.pmid: 22361734
references.citation: Nat Cell Biol. 2013 Jan;15(1):2-8
references.pmid: 23263379
references.citation: Mol Cancer Ther. 2013 Jan;12(1):94-103
references.pmid: 23136185
references.citation: Nat Commun. 2013;4:2544
references.pmid: 24149576
references.citation: CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29
references.pmid: 24399786
references.citation: Cancer Res. 2014 Dec 15;74(24):7161-7
references.pmid: 25477334
references.citation: Cell Death Dis. 2015;6:e1768
references.pmid: 25996295
references.citation: Cell Death Differ. 2015 Aug;22(8):1239-49
references.pmid: 26024390