title: [The impact of metabolic control on uteroplacental circulation parameters in pregnancies complicated by gestational hypertension and/or preeclampsia in pregnant women with pregestational diabetes].
abstract: OBJECTIVE
  The aim of the study was to evaluated the impact of metabolic control in pregnant women with PGDM on uteroplacental circulation parameters during pregnancy.
  
  
  METHODS
  The study group included 141 pregnant women divided into 3 subgroups: PE + GH group (n = 16)--woman suffering from PGDM, with superimposed PE or GH, the PGDM group (n = 84)--women suffering from PGDM without hypertension, and the control group--41 healthy women in uncomplicated pregnancy. All participants were monitored for metabolic control and uteroplacental circulation parameters during pregnancy. The survey was completed after the data from the perinatal period were collected.
  
  
  RESULTS
  The differences between the uterine artery pulsatility index (Pi UtA) in the first trimester of pregnancy expressed as a multiple of the median (MoM), were not statistically significant between the groups (p ≥ 0.42). Also, no statistically significant differences were observed between the groups Pi UtA in the second (p ≥ 0.33) and third trimester of pregnancy (p = 1.0). The rate of fetal growth was comparable in all groups. Infant birth weight percentile in the study groups did not differ statistically (p ≥ 0.15).
  
  
  CONCLUSIONS
  Tight metabolic control during pregnancy in women suffering from PGDM allows to obtain blood flow in the uteroplacental circulation which is comparable to their healthy pregnant peers.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Poprawski
authors.forename: Marek
authors.initials: M
authors.lastname: Pietryga
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zawiejska
authors.forename: Rafał
authors.initials: R
authors.lastname: Iciek
authors.forename: Ewa
authors.initials: E
authors.lastname: Wender-Ozegowska
authors.forename: Jacek
authors.initials: J
authors.lastname: Brazert
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000503:physiopathology*; D010920:Placenta / Q000098:blood supply*; D021041:Placental Circulation / Q000502:physiology*; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy; D011264:Pregnancy Trimesters / Q000097:blood; D011673:Pulsatile Flow; D012016:Reference Values; D014599:Uterus / Q000098:blood supply*; D055815:Young Adult