title: Imaging symptomatic bone morphogenetic protein-2-induced heterotopic bone formation within the spinal canal: case report.
abstract: Heterotopic bone formation within the spinal canal is a known complication of bone morphogenetic protein-2 (BMP-2) and presents a clinical and surgical challenge. Imaging modalities are routinely used for operative planning in this setting. Here, the authors present the case of a 59-year-old woman with cauda equina syndrome following intraoperative BMP-2 administration. Plain film myelographic studies showed a region of severe stenosis that was underappreciated on CT myelography due to a heterotopic bony lesion mimicking the dorsal aspect of a circumferentially patent thecal sac. When evaluating spinal stenosis under these circumstances, it is important to carefully consider plain myelographic images in addition to postmyelography CT images as the latter may underestimate the true degree of stenosis due to the potentially similar radiographic appearances of evolving BMP-2-induced heterotopic bone and intrathecal contrast. Alternatively, comparison of sequentially acquired noncontrast CT scans with CT myelographic images may also assist in distinguishing BMP-2-induced heterotopic bony lesions from the thecal sac. Further studies are needed to elucidate the roles of the available imaging techniques in this setting and to characterize the connection between the radiographic and histological appearances of BMP-2-induced heterotopic bone.
authors.affiliation: Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland.
authors.forename: Timothy
authors.initials: T
authors.lastname: Chryssikos
authors.affiliation: Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Crandall
authors.affiliation: Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Sansur
mesh_terms: D055396:Bone Morphogenetic Protein 2 / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009192:Myelography; D011128:Polyradiculopathy / Q000000981:diagnostic imaging* / Q000209:etiology; D013115:Spinal Canal / Q000000981:diagnostic imaging*; D013123:Spinal Fusion / Q000009:adverse effects* / Q000379:methods
chemical_list: D055396:Bone Morphogenetic Protein 2
keywords: BMP-2; BMP-2 = bone morphogenetic protein–2; PSO = pedicle subtraction osteotomy; heterotopic bone; myelography; spinal stenosis; technique