title: In Vitro Evaluation of the Effects of Multiple Oral Factors on Dental Implants Surfaces.
abstract: Presence of metal ions and debris resulting from corrosion processes of dental implants in vivo can elicit adverse tissue reactions, possibly leading to peri-implant bone loss and eventually implant failure. This study hypothesized that the synergistic effects of bacterial biofilm and micromotion can cause corrosion of dental implants and release of metal ions in vivo. The goal is to simulate the oral environment where an implant will be exposed to a combination of acidic electrochemical environment and mechanical forces. Four conditions were developed to understand the individual and synergistic effects of mechanical forces and bacterial biofilm on the surface of dental implants; In condition 1, it was found that torsional forces during surgical insertion did not generate wear particle debris or metal ions. In condition 2, fatigue tests were performed in a wet environment to evaluate the effect of cyclic occlusal forces. The mechanical forces applied on the implants were able to cause implant fracture as well as surface corrosion features such as discoloration, delamination, and fatigue cracks. Immersion testing (condition 3) showed that bacteria ( Streptococcus mutans ) were able to create an acidic condition that triggered surface damage such as discoloration, rusting, and pitting. A novel testing setup was developed to understand the conjoint effects of micromotion and bacterial biofilm (condition 4). Surface damage initiated by acidic condition due to bacteria (condition 3), can be accelerated in tandem with mechanical forces through fretting-crevice corrosion. Permanent damage to surface layers can affect osseointegration and deposition of metal ions in the surrounding tissues can trigger inflammation.
authors.affiliation: 1   Department of Bioengineering, University of Texas at Dallas, Richardson, Texas.
authors.forename: Sathyanarayanan
authors.initials: S
authors.lastname: Sridhar
authors.affiliation: 2   Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas.
authors.forename: Zain
authors.initials: Z
authors.lastname: Abidi
authors.affiliation: 3   Private periodontics practice, Dallas, Texas.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Wilson
authors.affiliation: 3   Private periodontics practice, Dallas, Texas.
authors.forename: Pilar
authors.initials: P
authors.lastname: Valderrama
authors.affiliation: 4   Department of Restorative Dentistry, University of Washington, Seattle, Wash.
authors.forename: Chandur
authors.initials: C
authors.lastname: Wadhwani
authors.affiliation: 2   Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas.
authors.forename: Kelli
authors.initials: K
authors.lastname: Palmer
authors.affiliation: 1   Department of Bioengineering, University of Texas at Dallas, Richardson, Texas.
authors.forename: Danieli C
authors.initials: DC
authors.lastname: Rodrigues
mesh_terms: D001732:Bite Force; D003343:Corrosion; D015921:Dental Implants; D006801:Humans; D016348:Osseointegration; D013499:Surface Properties; D014025:Titanium
chemical_list: D015921:Dental Implants; D014025:Titanium
keywords: dental implants; failure; fretting-crevice corrosion; modularity; osseointegration; oxide layer