title: Association of SLC30A8 gene polymorphism with type 2 diabetes, evidence from 46 studies: a meta-analysis.
abstract: The solute carrier family 30 member 8 (SLC30A8) gene may be involved in the development of type 2 diabetes mellitus (T2DM) through disrupting β-cell function. The aim of this study was to assess the association between SLC30A8 rs13266634 polymorphism and susceptibility to T2DM. We searched all reports regarding the association between SLC30A8 rs13266634 polymorphism and T2DM risk through Pubmed, Embase, and the Cochrane Library for English language reports and Chongqing VIP database, Wanfang data, CBMDisc, and CNKI for Chinese language studies. Allelic and genotype comparisons between cases and controls were evaluated, and odds ratios with 95 % confidence intervals were used to assess the strength of their association. A random effects model was selected. Publication bias was estimated using Begg's test. Forty-six studies were included in the analysis with a total of 71,890 cases and 96,753 controls. This meta-analysis suggests that SLC30A8 (rs13266634) polymorphism was associated with T2DM risk. Although previous meta-analyses have shown that this association was only found in Asian and European groups, and not in African populations, our analysis revealed the deleterious effect of SLC30A8 rs13266634 on T2DM in an African population when stratified by ethnicity under additive model even with a small number of studies.
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
authors.forename: Mengdi
authors.initials: M
authors.lastname: Fan
authors.affiliation: Department of Ultrasonography, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Li
authors.affiliation: Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Wang
authors.affiliation: Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
authors.forename: Suping
authors.initials: S
authors.lastname: Gu
authors.affiliation: Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
authors.forename: Sisi
authors.initials: S
authors.lastname: Dong
authors.affiliation: Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
authors.forename: Mengdie
authors.initials: M
authors.lastname: Chen
authors.affiliation: Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
authors.forename: Haimin
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Ultrasonography, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
authors.forename: Jinjue
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Wu
authors.affiliation: Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Pathophysiology, Obesity and Diabetes Center, Second Military Medical University, Shanghai, 200433, China.
authors.forename: Xuchao
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Pathophysiology, Obesity and Diabetes Center, Second Military Medical University, Shanghai, 200433, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Child Health, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. liupeining366@sina.com.
authors.forename: Peining
authors.initials: P
authors.lastname: Liu
authors.affiliation: Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. wallbb_1022@163.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Zheng
mesh_terms: D027682:Cation Transport Proteins / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D000075703:Zinc Transporter 8
chemical_list: D027682:Cation Transport Proteins; C492522:SLC30A8 protein, human; D000075703:Zinc Transporter 8
keywords: Gene polymorphism; Meta-analysis; Susceptibility; Type 2 diabetes
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