title: Low serum insulin-like growth factor-1 in patients with erectile dysfunction.
abstract: OBJECTIVE
  Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED.
  
  
  METHODS
  All men were evaluated for ED and divided into two groups: 80 patients suffering from ED for > 1 year and 80 subjects without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. IGF-1 levels were measured in serum by an automated chemiluminescence immunoassay. The relationship between IGF-1 levels and ED scores in patients was statistically evaluated.
  
  
  RESULTS
  The mean age of patients in ED group was 60.4 ± 11.3 years and 55.4 ± 9.6 in control group. The plasma IGF-1 levels were significantly lower in ED than in control group (96.5 ± 38.3 and 132.5 ± 53.3 ng/ mL, respectively, P < 0.001). The IGF-1 levels were positively correlated with ED score (r = 0.623, P < 0.01).
  
  
  CONCLUSIONS
  In this study serum IGF-1 levels were found to be associated with endothelial dysfunction that predicts ED. Serum IGF-1 level appears to be a specific predictor of ED, and it might be used in early prediction of ED in male population.
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Otunctemur
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Ozbek
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Sahin
authors.affiliation: Department of Urology, Derince Training and Research Hospital, Kocaeli, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Ozcan
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Dursun
authors.affiliation: Department of Urology, Istanbul Medipol University, School of Medicine, Istanbul, Turkey.
authors.forename: Emre Can
authors.initials: EC
authors.lastname: Polat
authors.affiliation: Department of Biochemistry, Kocaeli University, School of Medicine, Kocaeli, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cekmen
authors.affiliation: Department of Biochemistry, Kocaeli University, School of Medicine, Kocaeli, Turkey.
authors.forename: Ozgur Doga
authors.initials: OD
authors.lastname: Ozsoy
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Erkoc
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Eyup
authors.initials: E
authors.lastname: Danis
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Muammer
authors.initials: M
authors.lastname: Bozkurt
keywords: Endothelial dysfunction; Erectile dysfunction; Insulin-like growth factor-1; International Index of Erectile Function Score-5
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