title: Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains.
abstract: A novel BODIPY derivative was designed for biomedical applications. Its mono-quaternized structure ensured its water-solubility and suitable amphiphilicity. Showing no singlet oxygen generation to avoid damage to healthy cells, this new derivative proved to be an extremely promising antimicrobial agent, with activity equal or superior to ampicillin against MRS Staphylococcus strains with no short-term resistance issue. Its activity against MSS Staphylococcus strains was largely superior to those of ampicillin and reached the activity of vancomycin against MSS S. epidermidis. This latter result is in particular extremely promising for the treatment of hospital-acquired infections. Also the fluorescence properties of BODIPY allowed imaging of the uptake.
authors.affiliation: Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr.
authors.forename: Duygu
authors.initials: D
authors.lastname: Aydın Tekdaş
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. hongboonlee@um.edu.my.
authors.forename: Geetha
authors.initials: G
authors.lastname: Viswanathan
authors.affiliation: Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr.
authors.forename: Sevinc
authors.initials: S
authors.lastname: Zehra Topal
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Chung Yeng
authors.initials: CY
authors.lastname: Looi
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Won Fen
authors.initials: WF
authors.lastname: Wong
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Grace
authors.initials: G
authors.lastname: Min Yi Tan
authors.affiliation: Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr.
authors.forename: Yunus
authors.initials: Y
authors.lastname: Zorlu
authors.affiliation: Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr.
authors.forename: Ayşe Gül
authors.initials: AG
authors.lastname: Gürek
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. hongboonlee@um.edu.my.
authors.forename: Hong Boon
authors.initials: HB
authors.lastname: Lee
authors.affiliation: Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Dumoulin
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001896:Boron Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D013210:Staphylococcus / Q000145:classification / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000900:Anti-Bacterial Agents; D001896:Boron Compounds