title: Efficient computational simulation of actin stress fiber remodeling.
abstract: Understanding collagen and stress fiber remodeling is essential for the development of engineered tissues with good functionality. These processes are complex, highly interrelated, and occur over different time scales. As a result, excessive computational costs are required to computationally predict the final organization of these fibers in response to dynamic mechanical conditions. In this study, an analytical approximation of a stress fiber remodeling evolution law was derived. A comparison of the developed technique with the direct numerical integration of the evolution law showed relatively small differences in results, and the proposed method is one to two orders of magnitude faster.
authors.affiliation: a Department of Biomedical Engineering , Eindhoven University of Technology , Eindhoven , The Netherlands .|b Institute for Complex Molecular Systems , Eindhoven University of Technology , Eindhoven , The Netherlands .
authors.forename: T
authors.initials: T
authors.lastname: Ristori
authors.affiliation: a Department of Biomedical Engineering , Eindhoven University of Technology , Eindhoven , The Netherlands .
authors.forename: C
authors.initials: C
authors.lastname: Obbink-Huizer
authors.affiliation: a Department of Biomedical Engineering , Eindhoven University of Technology , Eindhoven , The Netherlands .
authors.forename: C W J
authors.initials: CW
authors.lastname: Oomens
authors.affiliation: a Department of Biomedical Engineering , Eindhoven University of Technology , Eindhoven , The Netherlands .|b Institute for Complex Molecular Systems , Eindhoven University of Technology , Eindhoven , The Netherlands .
authors.forename: F P T
authors.initials: FP
authors.lastname: Baaijens
authors.affiliation: a Department of Biomedical Engineering , Eindhoven University of Technology , Eindhoven , The Netherlands .|b Institute for Complex Molecular Systems , Eindhoven University of Technology , Eindhoven , The Netherlands .
authors.forename: S
authors.initials: S
authors.lastname: Loerakker
mesh_terms: D000199:Actins / Q000378:metabolism*; D016880:Anisotropy; D003094:Collagen / Q000378:metabolism; D003198:Computer Simulation; D022502:Stress Fibers / Q000378:metabolism*; D023822:Tissue Engineering
chemical_list: D000199:Actins; D003094:Collagen
keywords: Actin stress fiber remodeling; ODE system with periodic coefficients; analytical approximation; cyclic strain