title: Clinicopathological Significance of S100A10 Expression in Lung Adenocarcinomas.
abstract: BACKGROUND
  S100A10, of the S100 protein family, is reported to be involved in cancer cell invasion and metastasis. The aims of the present study were to immunohistochemically examine S100A10 expression in surgically resected lung adenocarcinomas, and evaluate any relationships with clinicopathological parameters and prognosis of patients.
  
  
  METHODS
  S100A10 expression was immunohistochemically studied in 202 consecutive resected lung adenocarcinomas, and its associations with clinicopathological parameters were evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of S100A10 expression on survival.
  
  
  RESULTS
  S100A10 expression was detected in 65 of the 202 (32.2%) lung adenocarcinomas, being significantly correlated with poorer differentiation (P =0.015), a higher pathological TNM stage (stages II and III) (P=0.004), more frequent and severe intratumoral vascular invasion (P=0.001), and a poorer prognosis (P=0.030). However, S100A10 expression was not an independent predictor of survival after controlling for clinicopathological factors.
  
  
  CONCLUSIONS
  The present study reveals that S100A10 is expressed in a subset of lung adenocarcinomas, and this is related to some clinicopathological parameters, although further studies are required to confirm the correlation between S100A10 expression and prognosis of lung adenocarcinoma patients.
authors.affiliation: Department of Respiratory Medicine, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan E-mail : yuichi@med.kitasato-u.ac.jp.
authors.forename: Ken
authors.initials: K
authors.lastname: Katono
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sato
authors.forename: Shi-Xu
authors.initials: SX
authors.lastname: Jiang
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Keita
authors.initials: K
authors.lastname: Saito
authors.forename: Ryo
authors.initials: R
authors.lastname: Nagashio
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ryuge
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Satoh
authors.forename: Makoto
authors.initials: M
authors.lastname: Saegusa
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Masuda
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D009418:S100 Proteins / Q000378:metabolism*
chemical_list: D009418:S100 Proteins