title: Iridociliary adenocarcinoma with oncocytic change in a dog.
abstract: An intraocular mass lesion was found in the left eyeball in a spayed female Pembroke Welsh Corgi dog. The surgically resected left eyeball was pathologically examined. Histologically, the mass lesion consisted of proliferation of the atypical cuboidal or columnar epithelial cells, arranging in papillary, tubular or solid form. In addition, some neoplastic cells showed oncocytic change characterized as large oval cells with numerous eosinophilic intracytoplasmic granules. Cytoplasm of the oncocytic cells showed dark blue granules by phosphotungstic acid-hematoxylin stain. Immunohistochemically, the oncocytic cells were intensely positive for cytochrome C. Based on these findings, the ocular mass was diagnosed as iridociliary adenocarcinoma with oncocytic change. The findings indicate that the oncocytic changes of the neoplastic epithelial cells might be caused by mitochondrial accumulation.
authors.affiliation: Sanritsu Zelkova Veterinary Laboratory, 2-5-8 Kuji, Takatsu-ku, Kawasaki-shi, Kanagawa 213-0032, Japan.
authors.forename: Mitsuteru
authors.initials: M
authors.lastname: Okawauchi
authors.forename: Masaya
authors.initials: M
authors.lastname: Tsuboi
authors.forename: Kazumi
authors.initials: K
authors.lastname: Nibe
authors.forename: Eiji
authors.initials: E
authors.lastname: Nagamine
authors.forename: Hideaki
authors.initials: H
authors.lastname: Iwane
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D002924:Ciliary Body / Q000473:pathology / Q000601:surgery; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D005260:Female; D015811:Iris Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D014604:Uveal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000662:veterinary*
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