title: Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes.
abstract: Type I interferon (IFN-I) elicits a complex cascade of events in response to microbial infection. Here, we review recent developments illuminating the large number of IFN-I species and describing their unique biologic functions.
authors.affiliation: Department of Immunology & Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Cherie T
authors.initials: CT
authors.lastname: Ng
authors.affiliation: Department of Molecular & Cellular Physiology and Department of Structural Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.
authors.forename: Juan L
authors.initials: JL
authors.lastname: Mendoza
authors.affiliation: Department of Molecular & Cellular Physiology and Department of Structural Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.
authors.forename: K Christopher
authors.initials: KC
authors.lastname: Garcia
authors.affiliation: Department of Immunology & Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: mbaobo@scripps.edu.
authors.forename: Michael B A
authors.initials: MB
authors.lastname: Oldstone
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007370:Interferon Type I / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D053633:Receptor, Interferon alpha-beta / Q000378:metabolism; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology
chemical_list: D007370:Interferon Type I; D053633:Receptor, Interferon alpha-beta
keywords: bacterial infection; interferon alpha-beta receptor; interferon-alpha; interferon-beta; pathogenesis; persistent viral infection; type 1 interferon
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