title: Novel molecular mechanisms and regeneration therapy for heart failure.
abstract: Heart failure (HF) is one of the leading causes of mortality in the world. Various molecular mechanisms have been proposed for HF, but its precise mechanisms are still largely unknown. In this review, summarizing the "President's Distinguished Lecture Award" of XX World Congress of International Society for Heart Research 2010 in Kyoto, Japan, we introduce recent our studies on HF, including 1) p53-induced suppression of Hif-1-induced angiogenesis as a novel mechanism of HF, 2) angiogenesis as a potential therapeutic strategy for HF, and 3) IGFBP-4 as a novel factor for cardiomyogenesis by inhibiting canonical Wnt signaling.
authors.affiliation: Onco-Cardiology Unit, Department of Cardiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537-8511, Japan; Japan Science and Technology Agency, CREST, Tokyo, Japan. Electronic address: oka-to@mc.pref.osaka.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Oka
authors.affiliation: Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morita
authors.affiliation: Japan Science and Technology Agency, CREST, Tokyo, Japan; Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: komuro-tky@umin.ac.jp.
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D006333:Heart Failure / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D018974:Insulin-Like Growth Factor Binding Protein 4 / Q000235:genetics; D024510:Muscle Development / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D012038:Regeneration; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D018974:Insulin-Like Growth Factor Binding Protein 4; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53