title: Lanostane-type triterpenes from the fungal endophyte Scleroderma UFSMSc1 (Persoon) Fries.
abstract: Two lanostane triterpenoids (sclerodols A and B) were isolated from the culture of the Eucalyptus grandis derived from the endophyte Scleroderma UFSM Sc1(Persoon) Fries together with three known compounds: one related triterpenoid lanosta-8,23-dien-3β,25-diol, the disaccharide α,β-trehalose, and the sugar alcohol mannitol. Their structures were elucidated on the basis of 2D NMR, HRME, and single-crystal X-ray diffraction data. The methanol crude extract and the isolated lanostane triterpenoids showed promising anticandidal activities.
authors.affiliation: Universidade Federal de Santa Maria, Departamento de Química, Camobi, Santa Maria, RS, Brazil.
authors.forename: Liziane M B
authors.initials: LM
authors.lastname: Morandini
authors.affiliation: Universidade Federal de Santa Maria, Departamento de Química, Camobi, Santa Maria, RS, Brazil.
authors.forename: Alexandre T
authors.initials: AT
authors.lastname: Neto
authors.affiliation: Universidade Federal de Santa Maria, Departamento de Química, Camobi, Santa Maria, RS, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Pedroso
authors.affiliation: Universidade Federal de Santa Maria, Departamento de Ciências do Solo, Camobi, Santa Maria, RS, Brazil.
authors.forename: Zaida I
authors.initials: ZI
authors.lastname: Antoniolli
authors.affiliation: Universidade Federal de Santa Maria, Departamento de Química, Camobi, Santa Maria, RS, Brazil.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Burrow
authors.affiliation: Universidade Federal de Santa Catarina, Departamento de Química, Trindade, Santa Catarina, SC, Brazil.
authors.forename: Adailton J
authors.initials: AJ
authors.lastname: Bortoluzzi
authors.affiliation: Universidade Federal de Santa Maria, Departamento de Química, Camobi, Santa Maria, RS, Brazil.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Mostardeiro
authors.affiliation: Universidade Federal de Santa Maria, Departamento de Química, Camobi, Santa Maria, RS, Brazil.
authors.forename: Ubiratan F
authors.initials: UF
authors.lastname: da Silva
authors.affiliation: Universidade Federal de Santa Maria, Departamento de Química, Camobi, Santa Maria, RS, Brazil.
authors.forename: Ionara I
authors.initials: II
authors.lastname: Dalcol
authors.affiliation: Universidade Federal de Santa Maria, Departamento de Química, Camobi, Santa Maria, RS, Brazil. Electronic address: afmorel@base.ufsm.br.
authors.forename: Ademir F
authors.initials: AF
authors.lastname: Morel
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001487:Basidiomycota / Q000378:metabolism*; D002175:Candida / Q000187:drug effects; D018360:Crystallography, X-Ray; D005052:Eucalyptus / Q000382:microbiology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D014315:Triterpenes; C000611249:sclerodol A; C000611250:sclerodol B
keywords: Anticandidal activity; Fungal endophyte; Lanostenoids; Scleroderma UFSMSc1 (Persoon) Fries