title: Odontogenic myxoma: a clinicopathological study in a South African population.
abstract: BACKGROUND
  Odontogenic myxoma is a benign, locally aggressive neoplasm of the jaws. Prevalence rates range between 0.5% and 17.7% of odontogenic tumours. There are few reports in the literature on this lesion in African populations, and therefore, this study aimed to report on odontogenic myxoma in a South African population over a 40-year period.
  
  
  METHODS
  The clinical records and orthopantomograms of 29 histopathologically diagnosed odontogenic myxoma were retrospectively analysed. Details of age, gender, ethnic origin and clinical, histological as well as radiological features were recorded.
  
  
  RESULTS
  The ages of patients ranged from 7 to 44 years with a mean of 21.3 years. The male-to-female ratio was 1:2.6 with the majority of patients being of mixed race and Africans. Clinically, 31% complained of pain while 58.6% had a history of swelling. The majority of odongenic myxomas (62.1%) were located in the mandible with the posterior region being most commonly affected. Multilocular lesions (69.2%) were more common and were significantly larger than unilocular lesions (P < 0.05). The outline of these tumours was mostly well-defined (84.6%) with different degrees of cortication. Only one tumour caused tooth resorption, while 20 cases (76.9%) caused tooth displacement. Six tumours expanded into the maxillary sinus, and 14 tumours caused expansion of the mandible.
  
  
  CONCLUSIONS
  Odontogenic myxomas have variable clinical, radiological and histological features. Most of these features in this population were similar to other populations. It is mandatory to use conventional radiographs along with histopathological examination to aid in arriving at an accurate diagnosis.
authors.affiliation: Department of Maxillo-Facial and Oral Surgery, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa.
authors.forename: Fadi
authors.initials: F
authors.lastname: Titinchi
authors.affiliation: Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
authors.forename: Bassam A
authors.initials: BA
authors.lastname: Hassan
authors.affiliation: Department of Maxillo-Facial and Oral Surgery, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa.
authors.forename: Jean A
authors.initials: JA
authors.lastname: Morkel
authors.affiliation: Department of Diagnostics and Radiology, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa.
authors.forename: Christoffel
authors.initials: C
authors.lastname: Nortje
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D008441:Maxillary Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D009232:Myxoma / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D009808:Odontogenic Tumors / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D015995:Prevalence; D012189:Retrospective Studies; D013019:South Africa / Q000453:epidemiology; D055815:Young Adult
keywords: South Africa; odontogenic myxoma; panoramic radiograph