title: Lipofilling of the Breast Does Not Increase the Risk of Recurrence of Breast Cancer: A Matched Controlled Study.
abstract: BACKGROUND
  Although many plastic surgeons perform autologous fat grafting (lipofilling) for breast reconstruction after oncologic surgery, it has not been established whether postoncologic lipofilling increases the risk of breast cancer recurrence. The authors assessed the risk of locoregional and systemic recurrence in patients who underwent lipofilling for breast reconstruction.
  
  
  METHODS
  The authors identified all patients who underwent segmental or total mastectomy for breast cancer (719 breasts) (i.e., cases) or breast cancer risk reduction or benign disease (305 cancer-free breasts) followed by breast reconstruction with lipofilling as an adjunct or primary procedure between June of 1981 and February of 2014. They also then identified matched patients with breast cancer treated with segmental or total mastectomy followed by reconstruction without lipofilling (670 breasts) (i.e., controls). The probability of locoregional recurrence was estimated by the Kaplan-Meier method.
  
  
  RESULTS
  Mean follow-up times after mastectomy were 60 months for cases, 44 months for controls, and 73 months for cancer-free breasts. Locoregional recurrence was observed in 1.3 percent of cases (nine of 719 breasts) and 2.4 percent of controls (16 of 670 breasts). Breast cancer did not develop in any cancer-free breast. The cumulative 5-year locoregional recurrence rates were 1.6 percent and 4.1 percent for cases and controls, respectively. Systemic recurrence occurred in 2.4 percent of cases and 3.6 percent of controls (p = 0.514). There was no primary breast cancer in healthy breasts reconstructed with lipofilling.
  
  
  CONCLUSIONS
  The study results showed no increase in locoregional recurrence, systemic recurrence, or second breast cancer. These findings support the oncologic safety of lipofilling in breast reconstruction.
  
  
  METHODS
  Risk, II.
authors.affiliation: Houston, Texas; and Ann Arbor, Mich. From the Departments of Plastic and Reconstructive Surgery, Surgical Oncology, Radiation Oncology, and Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center; and the Department of Breast Radiation Oncology, University of Michigan.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Kronowitz
authors.forename: Cosman Camilo
authors.initials: CC
authors.lastname: Mandujano
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Henry M
authors.initials: HM
authors.lastname: Kuerer
authors.forename: Benjamin
authors.initials: B
authors.lastname: Smith
authors.forename: Patrick
authors.initials: P
authors.lastname: Garvey
authors.forename: Reshma
authors.initials: R
authors.lastname: Jagsi
authors.forename: Limin
authors.initials: L
authors.lastname: Hsu
authors.forename: Summer
authors.initials: S
authors.lastname: Hanson
authors.forename: Vicente
authors.initials: V
authors.lastname: Valero
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D016462:Mammaplasty / Q000379:methods*; D008408:Mastectomy / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000517:prevention & control; D012189:Retrospective Studies; D013997:Time Factors; D014481:United States / Q000453:epidemiology
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