title: Impact of host genetic polymorphisms on vaccine induced antibody response.
abstract: Many host- and vaccine-specific factors modulate an antibody response. Host genetic polymorphisms, in particular, modulate the immune response in multiple ways on different scales. This review article describes how information on host genetic polymorphisms and corresponding immune cascades may be used to generate personalized vaccine strategies to optimize the antibody response.
authors.affiliation: a Applied Microbiology Research , Department of Biomedicine, University Basel , Basel , Switzerland.|b Department of Biosystems Science and Engineering , ETH Zürich , Basel , Switzerland.|c Swiss Institute of Bioinformatics , Basel , Switzerland.
authors.forename: Janina E
authors.initials: JE
authors.lastname: Linnik
authors.affiliation: a Applied Microbiology Research , Department of Biomedicine, University Basel , Basel , Switzerland.|d Clinical Microbiology, University Hospital Basel , Basel , Switzerland.
authors.forename: Adrian
authors.initials: A
authors.lastname: Egli
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D056724:Immunity, Humoral / Q000235:genetics*; D007252:Influenza Vaccines / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology; D008457:Measles / Q000517:prevention & control / Q000821:virology; D008458:Measles Vaccine / Q000276:immunology; D008459:Measles virus / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D057285:Precision Medicine; D049490:Systems Biology; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D008458:Measles Vaccine; D014612:Vaccines
keywords: GWAS; Influenza; Measles; SNP; antibodies; genetic polymorphism; immune response; individualized vaccination; systems biology; vaccine
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