title: Particles for Local Delivery of Proteins Using Intra-Articular Route.
abstract: Designing a vehicle for local delivery of proteins using intra-articular route is an attractive option to minimize the adverse effects associated with systemic exposure and to maximize the efficacy. Slowly dissolving silylated microparticles are designed with specific size and shape that are capable of extending the retention time of a model protein (bovine serum albumin) in the murine knee joint. No cytotoxicity is observed for the reconstituted formulation when tested against synovial fibroblasts and RAW 264.7 macrophages.
authors.affiliation: Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27695, USA.
authors.forename: Khosrow
authors.initials: K
authors.lastname: Khodabandehlou
authors.affiliation: Department of Chemistryand Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA.
authors.forename: Shaomin
authors.initials: S
authors.lastname: Tian
authors.affiliation: Department of Chemistryand Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA.|Institute for Nanomedicine, Eshelman School of Pharmacyand Institute for Advanced Materials, University of North Carolina, Chapel Hill, NC, 27599, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Luft
authors.affiliation: Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27695, USA.
authors.forename: Saad A
authors.initials: SA
authors.lastname: Khan
authors.affiliation: Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27695, USA.|Department of Chemistryand Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA.|Institute for Nanomedicine, Eshelman School of Pharmacyand Institute for Advanced Materials, University of North Carolina, Chapel Hill, NC, 27599, USA.|Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: DeSimone
mesh_terms: D000818:Animals; D002417:Cattle; D005620:Freund's Adjuvant / Q000737:chemistry / Q000276:immunology; D006207:Half-Life; D007719:Knee Joint / Q000378:metabolism; D019344:Lactic Acid; D051379:Mice; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D000067996:RAW 264.7 Cells; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D012710:Serum Albumin, Bovine; D019344:Lactic Acid; D005620:Freund's Adjuvant
keywords: bovine serum albumin; intra-articular; joint retention; microparticles; silylation
references.citation: J Pharm Sci. 2008 Nov;97(11):4622-54
references.pmid: 18306275
references.citation: J Am Chem Soc. 2008 Apr 23;130(16):5438-9
references.pmid: 18376832
references.citation: J Microencapsul. 2000 Mar-Apr;17(2):145-55
references.pmid: 10738690
references.citation: ACS Appl Mater Interfaces. 2015 Mar 18;7(10):5756-67
references.pmid: 25742193
references.citation: Nat Rev Rheumatol. 2014 Jan;10(1):11-22
references.pmid: 24189839
references.citation: Mol Pharm. 2011 Aug 1;8(4):1002-15
references.pmid: 21634436
references.citation: Arch Pharm Res. 2011 Nov;34(11):1887-97
references.pmid: 22139688
references.citation: Am J Pathol. 1985 Nov;121(2):224-34
references.pmid: 3904468
references.citation: Br J Pharmacol. 2004 Sep;143(1):143-51
references.pmid: 15289288
references.citation: J Appl Toxicol. 1999 May-Jun;19(3):163-5
references.pmid: 10362266
references.citation: Expert Opin Drug Deliv. 2009 Jan;6(1):17-26
references.pmid: 19236205
references.citation: Arthritis Rheum. 1998 Dec;41(12):2185-95
references.pmid: 9870875
references.citation: J Am Chem Soc. 2012 May 9;134(18):7978-82
references.pmid: 22545784
references.citation: Eur J Pharm Biopharm. 2009 Oct;73(2):205-18
references.pmid: 19545624
references.citation: Arthritis Rheum. 1960 Apr;3:152-7
references.pmid: 14438185
references.citation: J Microencapsul. 1994 Jul-Aug;11(4):445-54
references.pmid: 7931944
references.citation: J Pharm Pharmacol. 1984 Jul;36(7):431-6
references.pmid: 6146685
references.citation: Nat Mater. 2008 Mar;7(3):248-54
references.pmid: 18246072
references.citation: Adv Drug Deliv Rev. 2006 May 20;58(2):226-42
references.pmid: 16574267
references.citation: Biomaterials. 2009 Mar;30(9):1772-80
references.pmid: 19135244
references.citation: J Immunol. 2003 May 1;170(9):4793-801
references.pmid: 12707361
references.citation: J Pharm Pharmacol. 1987 Apr;39(4):290-5
references.pmid: 2884293
references.citation: Arthritis Rheum. 2006 Jan;54(1):264-70
references.pmid: 16385543
references.citation: Arthritis Rheum. 1987 Jan;30(1):57-63
references.pmid: 3814198
references.citation: Ann Rheum Dis. 1969 Nov;28(6):644-51
references.pmid: 5363246
references.citation: J Bone Joint Surg Br. 1997 Sep;79(5):837-43
references.pmid: 9331047
references.citation: Biomaterials. 2012 Oct;33(30):7665-75
references.pmid: 22818981
references.citation: J Drug Deliv. 2012;2012:941243
references.pmid: 22518316
references.citation: Pharm Res. 2002 Feb;19(2):132-9
references.pmid: 11883639
references.citation: J Rheumatol. 1989 Oct;16(10):1295-303
references.pmid: 2810254
references.citation: J Microencapsul. 2001 Jul-Aug;18(4):443-56
references.pmid: 11428674
references.citation: Arthritis Res Ther. 2009;11(3):R72
references.pmid: 19454011
references.citation: Ann Rheum Dis. 1987 Dec;46(12):934-7
references.pmid: 3426302
references.citation: J Struct Biol. 2002 Jul;139(1):46-54
references.pmid: 12372319
references.citation: Inflamm Res. 2004 Aug;53(8):363-72
references.pmid: 15316667
references.citation: Nat Med. 2009 Dec;15(12):1414-20
references.pmid: 19898488
references.citation: J Clin Invest. 1984 Nov;74(5):1850-9
references.pmid: 6501574
references.citation: Int J Pharm. 2001 Sep 11;226(1-2):39-46
references.pmid: 11532568
references.citation: Science. 1981 Jul 10;213(4504):233-5
references.pmid: 6787705