title: Strontium-doped calcium polyphosphate/ultrahigh molecular weight polyethylene composites: A new class of artificial joint components with enhanced biological efficacy to aseptic loosening.
abstract: To enhance implant stability and prolong the service life of artificial joint component, a new approach was proposed to improve the wear resistance of artificial joint component and endow artificial joint component with the biological efficacy of resistance to aseptic loosening. Strontium calcium polyphosphate (SCPP) were interfused in ultrahigh molecular weight polyethylene (UHMWPE) by a combination of liquid nitrogen ball-milling and flat-panel curing process to prepare the SCPP/UHMWPE composites. The micro-structure, mechanical characterization, tribological characterization and bioactivities of various SCPP/UHMWPE composites were investigated. The results suggested that this method could statistically improve the wear resistance of UHMWPE resulting from a good SCPP particle dispersion. Moreover, it is also observed that the SCPP/UHMWPE composites-wear particles could promote the production of OPG by osteoblasts and decrease the production of RANKL by osteoblasts, and then increase the OPG/RANKL ratio. This indicated that the SCPP/UHMWPE composites had potential efficacy to prevent and treat aseptic loosening. Above all, the SCPP/UHMWPE composites with a suitable SCPP content would be the promising materials for fabricating artificial joint component with ability to resist aseptic loosening.
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, PR China; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Gu
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, PR China.
authors.forename: Bingxue
authors.initials: B
authors.lastname: Huang
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, PR China.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Tian
authors.affiliation: Department of Oncology, the 452 Hospital of Chinese PLA, Chengdu 610021, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, PR China. Electronic address: yuxixun@163.com.
authors.forename: Xixun
authors.initials: X
authors.lastname: Yu
mesh_terms: D002460:Cell Line; D006801:Humans; D007595:Joint Prosthesis; D010006:Osteoblasts / Q000378:metabolism* / Q000473:pathology; D020959:Polyethylene / Q000737:chemistry*; D011122:Polyphosphates / Q000737:chemistry*; D011475:Prosthesis Failure; D013324:Strontium / Q000737:chemistry*
chemical_list: D011122:Polyphosphates; D020959:Polyethylene; D013324:Strontium
keywords: Aseptic loosening; Biological efficacy; SCPP/UHMWPE composites