title: MicroRNA-mediated interactions between host and hepatitis C virus.
abstract: MicroRNAs (miRNAs) are small noncoding RNAs. More than 2500 mature miRNAs are detected in plants, animals and several types of viruses. Hepatitis C virus (HCV), which is a positive-sense, single-stranded RNA virus, does not encode viral miRNA. However, HCV infection alters the expression of host miRNAs, either in cell culture or in patients with liver disease progression, such as liver fibrosis, cirrhosis, and hepatocellular carcinoma. In turn, host miRNAs regulate HCV life cycle through directly binding to HCV RNAs or indirectly targeting cellular mRNAs. Increasing evidence demonstrates that miRNAs are one of the centered factors in the interaction network between virus and host. The competitive viral and host RNA hypothesis proposes a latent cross-regulation pattern between host mRNAs and HCV RNAs. High loads of HCV RNA sequester and de-repress host miRNAs from their normal host targets and thus disturb host gene expression, indicating a means of adaptation for HCV to establish a persistent infection. Some special miRNAs are closely correlated with liver-specific disease progression and the changed levels of miRNAs are even higher sensitivity and specificity than those of traditional proteins. Therefore, some of them can serve as novel diagnostic/prognostic biomarkers in HCV-infected patients with liver diseases. They are also attractive therapeutic targets for development of new anti-HCV agents.
authors.affiliation: Hu Li, Jian-Dong Jiang, Zong-Gen Peng, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Li
authors.affiliation: Hu Li, Jian-Dong Jiang, Zong-Gen Peng, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Jiang
authors.affiliation: Hu Li, Jian-Dong Jiang, Zong-Gen Peng, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Zong-Gen
authors.initials: ZG
authors.lastname: Peng
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D018450:Disease Progression; D015967:Gene Expression Regulation, Viral; D005819:Genetic Markers; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D006526:Hepatitis C / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D005819:Genetic Markers; D035683:MicroRNAs; D012367:RNA, Viral
keywords: Biomarker; Hepatitis C virus; Host-virus interaction; MicroRNAs; Therapeutic targets
references.citation: J Biol Chem. 2008 Jun 27;283(26):18158-66
references.pmid: 18456660
references.citation: Acta Pharm Sin B. 2014 Aug;4(4):266-9
references.pmid: 26579394
references.citation: Biochem Biophys Res Commun. 2011 Aug 19;412(1):92-7
references.pmid: 21802413
references.citation: Lab Invest. 2010 Dec;90(12):1727-36
references.pmid: 20625373
references.citation: J Virol. 2012 Sep;86(18):10221-5
references.pmid: 22787204
references.citation: PLoS Pathog. 2012 Feb;8(2):e1002510
references.pmid: 22346748
references.citation: Nature. 2007 Oct 18;449(7164):919-22
references.pmid: 17943132
references.citation: Cell Host Microbe. 2013 Jun 12;13(6):678-90
references.pmid: 23768492
references.citation: J Transl Med. 2012;10:151
references.pmid: 22846613
references.citation: Annu Rev Microbiol. 2010;64:123-41
references.pmid: 20477536
references.citation: J Gastroenterol. 2013 Feb;48(2):169-76
references.pmid: 22965312
references.citation: Virology. 2011 Feb 20;410(2):336-44
references.pmid: 21185047
references.citation: J Virol. 1991 Mar;65(3):1105-13
references.pmid: 1847440
references.citation: PLoS One. 2013;8(8):e70744
references.pmid: 23950995
references.citation: Hepatology. 2015 Jan;61(1):77-87
references.pmid: 25069599
references.citation: PLoS One. 2012;7(11):e50826
references.pmid: 23226395
references.citation: Nature. 2003 Sep 25;425(6956):415-9
references.pmid: 14508493
references.citation: Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7154-9
references.pmid: 23536298
references.citation: Front Immunol. 2012 Mar 12;3:20
references.pmid: 22566904
references.citation: PLoS One. 2013;8(2):e55733
references.pmid: 23418453
references.citation: J Biol Chem. 2012 Dec 7;287(50):41922-30
references.pmid: 23095753
references.citation: J Virol. 2013 Feb;87(4):2193-205
references.pmid: 23221562
references.citation: J Biol Chem. 2009 Nov 13;284(46):32015-27
references.pmid: 19726678
references.citation: Cell. 2005 Jan 14;120(1):15-20
references.pmid: 15652477
references.citation: Hepatology. 2013 Sep;58(3):863-71
references.pmid: 23390075
references.citation: Int J Oncol. 2013 Dec;43(6):1737-44
references.pmid: 24085339
references.citation: Cell Mol Life Sci. 2012 Aug;69(15):2621-33
references.pmid: 22391672
references.citation: Hepatology. 2013 Feb;57(2):461-9
references.pmid: 22996292
references.citation: Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73
references.pmid: 24275495
references.citation: Expert Opin Biol Ther. 2012 Sep;12(9):1153-9
references.pmid: 22650365
references.citation: N Engl J Med. 2013 May 2;368(18):1685-94
references.pmid: 23534542
references.citation: Gastroenterology. 2007 Oct;133(4):1166-74
references.pmid: 17919492
references.citation: Nature. 2004 Sep 16;431(7006):350-5
references.pmid: 15372042
references.citation: Hepatol Res. 2009 Feb;39(2):177-86
references.pmid: 19208038
references.citation: Anticancer Agents Med Chem. 2011 Jul;11(6):500-21
references.pmid: 21554203
references.citation: Hepatology. 2010 Oct;52(4):1431-42
references.pmid: 20842632
references.citation: BMC Genomics. 2007;8:166
references.pmid: 17565689
references.citation: J Cancer. 2012;3:19-31
references.pmid: 22211142
references.citation: Cold Spring Harb Symp Quant Biol. 2006;71:369-76
references.pmid: 17381319
references.citation: Nat Rev Genet. 2011 Feb;12(2):99-110
references.pmid: 21245828
references.citation: J Virol. 2010 Nov;84(22):12048-57
references.pmid: 20826689
references.citation: Virology. 2010 Mar 1;398(1):57-67
references.pmid: 20006370
references.citation: Adv Drug Deliv Rev. 2007 Oct 10;59(12):1200-12
references.pmid: 17825945
references.citation: Cell. 1993 Dec 3;75(5):843-54
references.pmid: 8252621
references.citation: Cancer Res. 2009 Jul 15;69(14):5761-7
references.pmid: 19584283
references.citation: Science. 2005 Jul 22;309(5734):623-6
references.pmid: 15947137
references.citation: Sci Rep. 2013;3:1555
references.pmid: 23549102
references.citation: Gut. 2011 Mar;60(3):378-86
references.pmid: 20940285
references.citation: Trends Immunol. 2008 Jul;29(7):343-51
references.pmid: 18515182
references.citation: J Infect Dis. 2011 Jun 15;203(12):1753-62
references.pmid: 21606534
references.citation: Acta Pharm Sin B. 2014 Aug;4(4):241-7
references.pmid: 26579391
references.citation: J Hepatol. 2009 Mar;50(3):441-4
references.pmid: 19155089
references.citation: Hepatology. 2012 Nov;56(5):1631-40
references.pmid: 22610915
references.citation: Cancer Cell. 2011 Feb 15;19(2):232-43
references.pmid: 21316602
references.citation: Biomed Rep. 2015 Jan;3(1):93-97
references.pmid: 25469255
references.citation: J Hepatol. 2009 Mar;50(3):453-60
references.pmid: 19144437
references.citation: Nature. 2005 Dec 1;438(7068):685-9
references.pmid: 16258535
references.citation: Gut. 2012 Nov;61(11):1600-9
references.pmid: 22267590
references.citation: J Virol. 2015 Mar;89(6):3356-65
references.pmid: 25589644
references.citation: Expert Opin Biol Ther. 2014 Sep;14(9):1285-93
references.pmid: 24941322
references.citation: J Microbiol. 2014 Jun;52(6):445-51
references.pmid: 24871972
references.citation: J Virol. 2013 May;87(9):5270-86
references.pmid: 23449803
references.citation: Oncogene. 2006 Apr 20;25(17):2537-45
references.pmid: 16331254
references.citation: Cancer Res. 2010 Jun 15;70(12):5184-93
references.pmid: 20501828
references.citation: Annu Rev Nutr. 2004;24:377-99
references.pmid: 15459982
references.citation: Science. 2005 Sep 2;309(5740):1577-81
references.pmid: 16141076
references.citation: Biochem Biophys Res Commun. 2008 Oct 24;375(3):315-20
references.pmid: 18692484
references.citation: Protein Cell. 2014 May;5(5):348-56
references.pmid: 24723323
references.citation: Hepatology. 2010 May;51(5):1494-504
references.pmid: 20127796
references.citation: Science. 2010 Jun 18;328(5985):1563-6
references.pmid: 20558719
references.citation: Cell Metab. 2006 Feb;3(2):87-98
references.pmid: 16459310
references.citation: Genome Res. 2010 May;20(5):589-99
references.pmid: 20439436
references.citation: Cell. 2009 Jan 23;136(2):215-33
references.pmid: 19167326
references.citation: Rev Med Virol. 2014 May;24(3):169-85
references.pmid: 24591085
references.citation: Int J Cancer. 2013 Aug 15;133(4):816-24
references.pmid: 23390000
references.citation: Hepatology. 2011 Jan;53(1):209-18
references.pmid: 20890893
references.citation: Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5848-53
references.pmid: 17376867
references.citation: Nat Struct Mol Biol. 2012 Jun;19(6):586-93
references.pmid: 22664986
references.citation: Hepatology. 2013 Apr;57(4):1333-42
references.pmid: 23172780
references.citation: Cell. 2015 Mar 12;160(6):1099-110
references.pmid: 25768906