title: Optimization of the management of platelet concentrate stocks in the Basque Country using mathematical simulation.
abstract: OBJECTIVE
  The management of platelet concentrate (PC) stocks is not simple given their short shelf life and variable demand. In general, managers decide on PC production based on personal experience. The objective of this study was to provide a tool to help decide how many PC units to produce each day in a more rational and objective way.
  
  
  METHODS
  From the historical data on PCs produced, transfused and discarded in the Basque Country in 2012, a mathematical model was built, based on the normality of the time series of the transfusions performed on each day of the week throughout the year. This model was implemented in an easy-to-use Excel spreadsheet and validated using real production data from 2013.
  
  
  RESULTS
  Comparing with real 2013 data, in the best scenario, the number of PC units that expired was 87·7% lower, PC production, 14·3% lower and the age of the PCs transfused nearly 1-day younger in the simulation. If we want to ensure a minimum stock at the end of each day, the outdating rate and average age of the transfused PCs progressively increase.
  
  
  CONCLUSIONS
  The practical application of the designed tool can facilitate decision-making about how many PC units to produce each day, resulting in very significant reductions in PC production and wastage and corresponding cost savings, together with an almost 1 day decrease in the mean age of PCs transfused.
authors.affiliation: Basque Centre for Transfusion and Human Tissues (CVTTH), Galdakao, Bizkaia, Spain.
authors.forename: M Á
authors.initials: MÁ
authors.lastname: Pérez Vaquero
authors.affiliation: Department of Applied Mathematics, Statistics and Operations Research, University of the Basque Country - UPV/EHU, Leioa, Bizkaia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Gorria
authors.affiliation: Department of Applied Mathematics, Statistics and Operations Research, University of the Basque Country - UPV/EHU, Leioa, Bizkaia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Lezaun
authors.affiliation: Department of Statistical Methods, Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Zaragoza, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: López
authors.affiliation: Basque Centre for Transfusion and Human Tissues (CVTTH), Galdakao, Bizkaia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Monge
authors.affiliation: Basque Centre for Transfusion and Human Tissues (CVTTH), Galdakao, Bizkaia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Eguizabal
authors.affiliation: Basque Centre for Transfusion and Human Tissues (CVTTH), Galdakao, Bizkaia, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Vesga
mesh_terms: D001792:Blood Platelets / Q000166:cytology*; D001793:Blood Preservation / Q000379:methods*; D006801:Humans; D008962:Models, Theoretical; D013030:Spain; D013997:Time Factors
keywords: mathematical simulation; optimization; platelet concentrate stocks