title: [Clinical significance of dynamic changes in serum inflammatory cell factors after acute paraquat poisoning].
abstract: OBJECTIVE
  To investigate the clinical significance of dynamic changes in the serum inflammatory cell factors consisting of β-endorphin (β-EP) , endothelins (ET) , tumor necrosis factor (TNF) , and nitric oxide (NO) after acute paraquat poisoning (APP).
  
  
  METHODS
  The 26 patients with APP (as observation group) were treated and the serum levels of plasma β-EP, ET, TNF, and NO were measured simultaneously. The 20 healthy volunteers from relatives of the patients (as control group) were also included in the study and their serum levels of β-EP, ET, TNF, and NO were measured.
  
  
  RESULTS
  In the 26 patients with APP, 10 were cured and 16 died. The serum levels of β-EP, ET, NO, and TNF in the 10 cured patients increased significantly immediately after admission, reached the peak values on day 2, and then decreased gradually and returned to the normal ranges after day 9. The serum levels of β-EP, ET, NO, and TNF in the 16 dead patients increased significantly on admission and kept rising in the course of treatment. The dead patients had significantly increased serum levels of β-EP, ET, NO, and TNF compared with the cured patients (all P<0.01).
  
  
  CONCLUSIONS
  Compared with those in cured patients with APP, the serum levels of β-EP, ET, NO, and TNF in dead patients with APP are significantly higher, keep rising, and maintain at high levels, indicating a severe condition.
authors.affiliation: Department of Emergency, The General Hospital of Jianghan Oil Field in Qianjiang City in Hubei Province, Qianjiang, Hubei Province 433124, China.
authors.forename: Shuming
authors.initials: S
authors.lastname: Yang
mesh_terms: D016022:Case-Control Studies; D016232:Endothelins / Q000097:blood*; D006801:Humans; D009569:Nitric Oxide / Q000097:blood*; D010269:Paraquat / Q000506:poisoning*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D016232:Endothelins; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D001615:beta-Endorphin; D010269:Paraquat