title: Knee flexion contracture treated with botulinum toxin type A in patients with haemophilia (PWH).
abstract: BACKGROUND
  Knee flexion contracture (KFC) remains a common complication of haemoarthrosis in children and young adults with haemophilia. If the KFC is not treated properly it produces disability, postural and gait abnormalities.
  
  
  OBJECTIVE
  Evaluate the effectiveness of conservative treatment of KFC with Botulinum toxin type A (BTX-A) in PWH.
  
  
  METHODS
  Seventeen patients were treated, with 21 affected knees. Mean age was 26 years. The mean follow up was 12 months. We evaluated flexion and KFC pretreatment BTX-A and up to 12 months posttreatment. BTX-A application was in hamstring and calf muscles. To evaluate the function, a questionnaire about different activities was made, and it was checked 3, 6 and 12 months after BTX-A. According to the degree of KFC, knees were divided into 3 groups: Group 1: -10° to -30° (n = 10), Group 2: -31° to -45° (n = 6) Group 3: -46° or more (n = 5).
  
  
  RESULTS
  The average KFC improved from -38° to -24°. The improvement was 14° (P < 0.001). The average KFC improvement was 9° in group 1, 17° in group 2, and 23° in group 3. There was a high correlation between the improvement in KFC and the total score of the questionnaire R = 0.77.
  
  
  CONCLUSIONS
  Treatment of KFC with BTX-A improves knee-related functional activities, with the advantage of being a low-cost procedure and easy to apply.
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, General Hospital Juan A. Fernández, Buenos Aires, Argentina.|Foundation of Haemophilia, Buenos Aires, Argentina.
authors.forename: C
authors.initials: C
authors.lastname: Daffunchio
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, General Hospital Juan A. Fernández, Buenos Aires, Argentina.|Foundation of Haemophilia, Buenos Aires, Argentina.
authors.forename: H
authors.initials: H
authors.lastname: Caviglia
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, General Hospital Juan A. Fernández, Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Nassif
authors.affiliation: Foundation of Haemophilia, Buenos Aires, Argentina.
authors.forename: N
authors.initials: N
authors.lastname: Morettil
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, General Hospital Juan A. Fernández, Buenos Aires, Argentina.|Foundation of Haemophilia, Buenos Aires, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Galatro
mesh_terms: D000293:Adolescent; D000328:Adult; D019274:Botulinum Toxins, Type A / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D003286:Contracture / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007719:Knee Joint / Q000187:drug effects* / Q000503:physiopathology*; D008875:Middle Aged; D016059:Range of Motion, Articular / Q000187:drug effects*; D020127:Recovery of Function / Q000187:drug effects; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D019274:Botulinum Toxins, Type A
keywords: botulinum toxin type A; haemophilia; knee flexion contracture