title: Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.
abstract: A variety of 2,6-modified purine 2'-C-methylribonucleosides and their phosphoramidate prodrugs were synthesized and evaluated for inhibition of HCV RNA replication in Huh-7 cells and for cytotoxicity in various cell lines. Cellular pharmacology and HCV polymerase incorporation studies on the most potent and selective compound are reported.
authors.affiliation: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center , Atlanta, Georgia 30322, United States.
authors.forename: Longhu
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center , Atlanta, Georgia 30322, United States.
authors.forename: Hongwang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center , Atlanta, Georgia 30322, United States.
authors.forename: Sijia
authors.initials: S
authors.lastname: Tao
authors.affiliation: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center , Atlanta, Georgia 30322, United States.
authors.forename: Maryam
authors.initials: M
authors.lastname: Ehteshami
authors.affiliation: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center , Atlanta, Georgia 30322, United States.
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Cho
authors.affiliation: CoCrystal Pharma, Inc. , Tucker, Georgia 30084, United States.
authors.forename: Tamara R
authors.initials: TR
authors.lastname: McBrayer
authors.affiliation: CoCrystal Pharma, Inc. , Tucker, Georgia 30084, United States.
authors.forename: Philip
authors.initials: P
authors.lastname: Tharnish
authors.affiliation: CoCrystal Pharma, Inc. , Tucker, Georgia 30084, United States.
authors.forename: Tony
authors.initials: T
authors.lastname: Whitaker
authors.affiliation: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center , Atlanta, Georgia 30322, United States.
authors.forename: Franck
authors.initials: F
authors.lastname: Amblard
authors.affiliation: CoCrystal Pharma, Inc. , Tucker, Georgia 30084, United States.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Coats
authors.affiliation: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center , Atlanta, Georgia 30322, United States.
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
keywords: HCV; antiviral; nucleoside; phosphoramidate prodrug; purine
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