title: Fertility-Sparing Options in Young Women with Cervical Cancer.
abstract: Cervical cancer (CC) is the fourth most frequent tumor and the fourth most common cause of cancer death among women worldwide. Furthermore, more than 40 % of women with early CC are affected during reproductive age and wish to remain fertile. Thus, many patients demand a more conservative policy for managing these lesions in order to have an uneventful pregnancy in the near future. For this reason, interest in fertility preservation strategies has been increasing, and the number of published studies on this topic has grown significantly. Conization was the first fertility-sparing surgical procedure tested in stage IA1 CC. However, in recent decades, other strategies have been tested, particularly for more advanced tumors. The aim of this review is to analyze the main techniques performed in patients with CC who are eligible for fertility-sparing surgery, with particular attention paid to open questions and controversies.
authors.affiliation: European Institute of Oncology "IEO,", Via Giuseppe Ripamonti 435, 20141, Milan, Italy. federica.tomao@ieo.it.|University "Sapienza", Sapienza, Rome. federica.tomao@ieo.it.
authors.forename: Federica
authors.initials: F
authors.lastname: Tomao
authors.affiliation: National Cancer Institute "Regina Elena", Regina Elena, Rome.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Corrado
authors.affiliation: European Institute of Oncology "IEO,", Via Giuseppe Ripamonti 435, 20141, Milan, Italy.
authors.forename: Fedro Alessandro
authors.initials: FA
authors.lastname: Peccatori
authors.affiliation: European Institute of Oncology "IEO,", Via Giuseppe Ripamonti 435, 20141, Milan, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Boveri
authors.affiliation: European Institute of Oncology "IEO,", Via Giuseppe Ripamonti 435, 20141, Milan, Italy.
authors.forename: Eleonora Petra
authors.initials: EP
authors.lastname: Preti
authors.affiliation: European Institute of Oncology "IEO,", Via Giuseppe Ripamonti 435, 20141, Milan, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Colombo
authors.affiliation: European Institute of Oncology "IEO,", Via Giuseppe Ripamonti 435, 20141, Milan, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Landoni
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D019092:Conization; D018450:Disease Progression; D005260:Female; D059247:Fertility Preservation / Q000379:methods; D006801:Humans; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments / Q000379:methods*; D017410:Practice Guidelines as Topic; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy*
keywords: Cervical cancer; Conization; Fertility sparing; Neoadjuvant chemotherapy; Trachelectomy; Uterus transplantation
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