title: Effect of a CGMS and SMBG on Maternal and Neonatal Outcomes in Gestational Diabetes Mellitus: a Randomized Controlled Trial.
abstract: In this study, we sought to investigate the effects of a continuous glucose monitoring system (CGMS) on maternal and neonatal outcomes. A total of 106 women with gestational diabetes mellitus (GDM) in gestational weeks 24-28 were randomly allocated to the antenatal care plus CGMS group or the self-monitoring blood glucose (SMBG) group. The CGMS group was subdivided into early and late subgroups. There were no significant differences in prenatal or obstetric outcomes, e.g., caesarean delivery rate, Apgar score at 5 min, macrosomia or neonatal hypoglycaemia, between the CGMS and SMBG groups. The CGMS group had lower glycated haemoglobin (HbA1C) levels than the SMBG group; however, the difference was not statistically significant. The proportion of GDM women with excessive gestational weight gain was lower in the CGMS group than in the SMBG group (33.3% vs. 56.4%, P = 0.039), and women who initiated CGMS earlier gained less weight (P = 0.017). The mode of blood glucose monitoring (adjusted OR 2.40; 95% CI 1.030-5.588; P = 0.042) and pre-pregnancy BMI (adjusted OR 0.578; 95% CI 0.419-0.798; P = 0.001) were independent factors for weight gain. In conclusion, early CGMS for GDM mothers reduces gestational weight gain. A follow-up study with a large cohort is needed.
authors.affiliation: Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, No.87 DingJiaQiao Road, Nanjing, 210009, PR China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, No.87 DingJiaQiao Road, Nanjing, 210009, PR China.
authors.forename: Zilin
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, No.87 DingJiaQiao Road, Nanjing, 210009, PR China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Obstetrics &Gynecology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Obstetrics &Gynecology, Nanjing Maternity and Child Health Care Hospital, Nanjing, PR China.
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Ding
authors.affiliation: Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, No.87 DingJiaQiao Road, Nanjing, 210009, PR China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wang
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis / Q000379:methods; D001786:Blood Glucose; D015190:Blood Glucose Self-Monitoring / Q000379:methods; D016640:Diabetes, Gestational / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin
references.citation: Int J Endocrinol. 2013;2013:279021
references.pmid: 24319455
references.citation: Diabetes Educ. 2002 May-Jun;28(3):435-43
references.pmid: 12073958
references.citation: Diabetes Res Clin Pract. 2007 Aug;77(2):174-9
references.pmid: 17234297
references.citation: Diabet Med. 1998 Jul;15(7):539-53
references.pmid: 9686693
references.citation: N Engl J Med. 2005 Jun 16;352(24):2477-86
references.pmid: 15951574
references.citation: Obstet Gynecol. 2003 Apr;101(4):633-8
references.pmid: 12681863
references.citation: J Perinatol. 2008 Oct;28(10):657-64
references.pmid: 18633419
references.citation: Pediatrics. 2011 Mar;127(3):575-9
references.pmid: 21357346
references.citation: Diabetes Care. 2009 Dec;32(12):2236-41
references.pmid: 19940226
references.citation: J Matern Fetal Neonatal Med. 2010 Oct;23(10):1193-9
references.pmid: 20059437
references.citation: Obstet Gynecol. 2006 Nov;108(5):1153-61
references.pmid: 17077237
references.citation: Iran J Reprod Med. 2013 Apr;11(4):325-34
references.pmid: 24639763
references.citation: Exp Clin Endocrinol Diabetes. 2009 Oct;117(9):486-9
references.pmid: 19536735
references.citation: Diabetes Care. 1998 Aug;21 Suppl 2:B131-7
references.pmid: 9704240
references.citation: Am J Clin Nutr. 2013 May;97(5):1100-6
references.pmid: 23553161
references.citation: Diabetes Care. 2007 Jul;30 Suppl 2:S251-60
references.pmid: 17596481
references.citation: Obstet Gynecol. 2004 Jun;103(6):1229-34
references.pmid: 15172857
references.citation: Matern Child Health J. 2013 Jan;17(1):85-94
references.pmid: 22322428
references.citation: BMJ. 2008;337:a1680
references.pmid: 18818254
references.citation: Exp Clin Endocrinol Diabetes. 2004 Nov;112(10):556-60
references.pmid: 15578329
references.citation: N Engl J Med. 1995 Nov 9;333(19):1237-41
references.pmid: 7565999
references.citation: Diabetes Care. 2011 Jan;34 Suppl 1:S11-61
references.pmid: 21193625
references.citation: Diabetes Technol Ther. 2013 Feb;15(2):172-9
references.pmid: 23268584
references.citation: Am J Clin Nutr. 2012 Jun;95(6):1432-7
references.pmid: 22552028
references.citation: Lancet. 2010 Sep 18;376(9745):937-8
references.pmid: 20691468
references.citation: BMC Public Health. 2011;11:179
references.pmid: 21429234
references.citation: Obstet Gynecol. 2008 Nov;112(5):1015-22
references.pmid: 18978100
references.citation: Matern Child Health J. 1998 Jun;2(2):111-6
references.pmid: 10728266
references.citation: Diabetes. 2003 Feb;52(2):463-9
references.pmid: 12540622
references.citation: Diabetes Care. 2010 Mar;33(3):676-82
references.pmid: 20190296
references.citation: Diabetes Care. 2012 Apr;35(4):780-6
references.pmid: 22357187
references.citation: J Obstet Gynaecol Res. 2012 Jan;38(1):208-14
references.pmid: 22070342
references.citation: Curr Diab Rep. 2013 Feb;13(1):34-42
references.pmid: 23081851
references.citation: Pediatrics. 2013 Jan;131(1):56-63
references.pmid: 23230067
references.citation: Diabetes Care. 1997 Jul;20(7):1087-92
references.pmid: 9203442
references.citation: Gynecol Obstet Invest. 2007;63(1):45-8
references.pmid: 16931885
references.citation: Endocr Rev. 2010 Apr;31(2):171-82
references.pmid: 19966012
references.citation: Diabetes Care. 1998 Aug;21 Suppl 2:B161-7
references.pmid: 9704245
references.citation: Diabetes Care. 2013 Jul;36(7):1877-83
references.pmid: 23349548
references.citation: Diabetes Technol Ther. 2005 Feb;7(1):109-14
references.pmid: 15738708
references.citation: Acta Obstet Gynecol Scand. 2010 Sep;89(9):1233-7
references.pmid: 20804351
references.citation: Diabet Med. 2014 Mar;31(3):352-6
references.pmid: 24341466
references.citation: Obstet Gynecol. 2012 Mar;119(3):560-5
references.pmid: 22353954
references.citation: Am J Obstet Gynecol. 1989 Sep;161(3):646-53
references.pmid: 2782347