title: [TRIGGER, SIGNALING MECHANISM AND END EFFECTOR OF CARDIOPROTECTIVE EFFECT OF REMOTE POSTCONDITIONING OF HEART].
abstract: Trigger of remote postconditioning (RP) is high molecular weight peptide(s). Nitric oxide and adenosine act as intermediaries between the peptide and the intracellular structures. The autonomic nervous system is not involved in the RP. In RP signaling mechanism protein kinase C, PI3 kinase, Akt kinase, aldehyde dehydrogenase are involved. A hypothetical end effector of RP is BKca channel.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: A V
authors.initials: AV
authors.lastname: Mukhomedzvanov
authors.forename: A S
authors.initials: AS
authors.lastname: Sementsov
mesh_terms: D000241:Adenosine / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D057775:Ischemic Postconditioning; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits / Q000235:genetics / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism*; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D011493:Protein Kinase C / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*
chemical_list: C494841:KCNMA1 protein, human; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; D010455:Peptides; D009569:Nitric Oxide; D000444:Aldehyde Dehydrogenase; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D011493:Protein Kinase C; D000241:Adenosine