title: Naphthalenones and Depsidones from a Sponge-Derived Strain of the Fungus Corynespora cassiicola.
abstract: Two new naphthalenones, corynenones A and B (1 and 2), and one new depsidone, corynesidone E (3), together with one known depsidone, corynesidone A (4) and two known diphenyl ethers, corynethers A (5) and B (6), were isolated from the sponge-derived fungus Corynespora cassiicola XS-20090I7. Their structures including absolute configurations were determined by spectroscopic data and electronic circular dichroism (ECD) spectra. Compounds 4 and 5 showed cytotoxicity against human promyelocytic leukemia HL-60 and human cervical carcinoma HeLa cell lines.
authors.affiliation: Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. lanseyimi@sina.com.
authors.forename: Dong-Lin
authors.initials: DL
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. shaochanglun@163.com.
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
authors.affiliation: Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. chaoyi0411@126.com.
authors.forename: Chao-Yi
authors.initials: CY
authors.lastname: Wang
authors.affiliation: Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. caoyuxiaowu@163.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.affiliation: Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. yangljshw@163.com.
authors.forename: Lu-Jia
authors.initials: LJ
authors.lastname: Yang
authors.affiliation: Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. changyun@ouc.edu.cn.|Institute of Evolution &amp; Marine Biodiversity, Ocean University of China, Qingdao 266003, China. changyun@ouc.edu.cn.
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000382:microbiology*; D004718:Saccharomycetales / Q000737:chemistry*
chemical_list: D053630:Depsides; D007783:Lactones; D009281:Naphthalenes; C000875:depsidone
keywords: Corynespora cassiicola; cytotoxicity; depsidone; naphthalenone; sponge-derived fungus
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