title: Thickness of the Meniscal Lamellar Layer: Correlation with Indentation Stiffness and Comparison of Normal and Abnormally Thick Layers by Using Multiparametric Ultrashort Echo Time MR Imaging.
abstract: Purpose To determine the relationship between lamellar layer thickness on ultrashort echo time (UTE) magnetic resonance (MR) images and indentation stiffness of human menisci and to compare quantitative MR imaging values between two groups with normal and abnormally thick lamellar layers. Materials and Methods This was a HIPAA-compliant, institutional review board-approved study. Nine meniscal pieces were obtained from seven donors without gross meniscal pathologic results (mean age, 57.4 years ± 14.5 [standard deviation]). UTE MR imaging and T2, UTE T2*, and UTE T1ρ mapping were performed. The presence of abnormal lamellar layer thickening was determined and thicknesses were measured. Indentation testing was performed. Correlation between the thickness and indentation stiffness was assessed, and mean quantitative MR imaging values were compared between the groups. Results Thirteen normal lamellar layers had mean thickness of 232 μm ± 85 and indentation peak force of 1.37 g ± 0.87. Four abnormally thick lamellar layers showed mean thickness of 353.14 μm ± 98.36 and peak force 0.72 g ± 0.31. In most cases, normal thicknesses showed highly positive correlation with the indentation peak force (r = 0.493-0.912; P < .001 to .05). However, the thickness in two abnormal lamellar layers showed highly negative correlation (r = -0.90, P < .001; and r = -0.23, P = .042) and no significant correlation in the others. T2, UTE T2*, and UTE T1ρ values in abnormally thick lamellar layers were increased compared with values in normal lamellar layers, although only the UTE T2* value showed significant difference (P = .010). Conclusion Variation of lamellar layer thickness in normal human menisci was evident on two-dimensional UTE images. In normal lamellar layers, thickness is highly and positively correlated with surface indentation stiffness. UTE T2* values may be used to differentiate between normal and abnormally thickened lamellar layers. (©) RSNA, 2016.
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Ja-Young
authors.initials: JY
authors.lastname: Choi
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Reni
authors.initials: R
authors.lastname: Biswas
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Won C
authors.initials: WC
authors.lastname: Bae
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Robert
authors.initials: R
authors.lastname: Healey
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Michael
authors.initials: M
authors.lastname: Im
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Sheronda
authors.initials: S
authors.lastname: Statum
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Eric Y
authors.initials: EY
authors.lastname: Chang
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Jiang
authors.initials: J
authors.lastname: Du
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Graeme M
authors.initials: GM
authors.lastname: Bydder
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Darryl
authors.initials: D
authors.lastname: D'Lima
authors.affiliation: From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (J.Y.C.); Department of Radiology, University of California-San Diego Medical Center, 3350 La Jolla Village Dr, Mail Code 8226, San Diego, CA 92103 (R.B., W.C.B., M.I., S.S., E.Y.C., J.D., G.M.B., C.B.C.); Department of Orthopedic Surgery, University of California, La Jolla, Calif (R.H.); Radiology Service, Veterans Administration San Diego Healthcare System, La Jolla, Calif (E.Y.C., C.B.C.); and Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, Calif (D.D.).
authors.forename: Christine B
authors.initials: CB
authors.lastname: Chung
mesh_terms: D001696:Biomechanical Phenomena; D002102:Cadaver; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D000072600:Meniscus / Q000033:anatomy & histology* / Q000473:pathology*; D008875:Middle Aged
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