title: Risk factors predictive of occult cancer detection in patients with unprovoked venous thromboembolism.
abstract: Risk factors predictive of occult cancer detection in patients with a first unprovoked symptomatic venous thromboembolism (VTE) are unknown. Cox proportional hazard models and multivariate analyses were performed to assess the effect of specific risk factors on occult cancer detection within 1 year of a diagnosis of unprovoked VTE in patients randomized in the Screening for Occult Malignancy in Patients with Idiopathic Venous Thromboembolism (SOME) trial. A total of 33 (3.9%; 95% CI, 2.8%-5.4%) out of the 854 included patients received a new diagnosis of cancer at 1-year follow-up. Age ≥ 60 years (hazard ratio [HR], 3.11; 95% CI, 1.41-6.89; ITALIC! P= .005), previous provoked VTE (HR, 3.20; 95% CI, 1.19-8.62; ITALIC! P= .022), and current smoker status (HR, 2.80; 95% CI, 1.24-6.33; ITALIC! P= .014) were associated with occult cancer detection. Age, prior provoked VTE, and smoking status may be important predictors of occult cancer detection in patients with first unprovoked VTE. This trial was registered atwww.clinicaltrials.govas #NCT00773448.
authors.affiliation: Department of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada;
authors.forename: Ryma
authors.initials: R
authors.lastname: Ihaddadene
authors.affiliation: Ottawa Hospital Research Institute, Ottawa, ON, Canada;
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Corsi
authors.affiliation: Department of Medicine, and Department of Epidemiology and Biostatistics, University of Western Ontario, London, ON, Canada;
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lazo-Langner
authors.affiliation: Department of Hematology, Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada; Department of Medicine, Dalhousie University, Halifax, NS, Canada;
authors.forename: Sudeep
authors.initials: S
authors.lastname: Shivakumar
authors.affiliation: Department of Medicine, University of Manitoba, Winnipeg, MB, Canada; Department of Hematology and Medical Oncology, CancerCare Manitoba, Winnipeg, MB, Canada;
authors.forename: Ryan
authors.initials: R
authors.lastname: Zarychanski
authors.affiliation: Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC, Canada; Center for Clinical Epidemiology, Lady Davis Institute, Montreal, QC, Canada;
authors.forename: Vicky
authors.initials: V
authors.lastname: Tagalakis
authors.affiliation: Department of Medicine, McGill University, Montreal, QC, Canada; Division of Hematology, Montreal General Hospital and St. Mary's Hospital, Montreal, QC, Canada;
authors.forename: Susan
authors.initials: S
authors.lastname: Solymoss
authors.affiliation: Department of Medicine, Université de Montréal, Montreal, QC, Canada; Sacre Coeur Hospital, Montreal, QC, Canada;
authors.forename: Nathalie
authors.initials: N
authors.lastname: Routhier
authors.affiliation: St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada; and.
authors.forename: James
authors.initials: J
authors.lastname: Douketis
authors.affiliation: Department of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada; The Ottawa Hospital, Ottawa, ON, Canada.
authors.forename: Gregoire
authors.initials: G
authors.lastname: Le Gal
authors.affiliation: Department of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada; The Ottawa Hospital, Ottawa, ON, Canada.
authors.forename: Marc
authors.initials: M
authors.lastname: Carrier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*
references.citation: Ann Intern Med. 2008 Sep 2;149(5):323-33
references.pmid: 18765702
references.citation: J Thromb Haemost. 2004 Jun;2(6):884-9
references.pmid: 15140122
references.citation: Thromb Res. 2015 Apr;135(4):666-72
references.pmid: 25708926
references.citation: Arch Intern Med. 2005 Aug 8-22;165(15):1782-7
references.pmid: 16087828
references.citation: Thromb Haemost. 2007 Oct;98(4):756-64
references.pmid: 17938798
references.citation: J Thromb Haemost. 2010 May;8(5):1126-7
references.pmid: 20149076
references.citation: N Engl J Med. 1998 Apr 23;338(17):1169-73
references.pmid: 9554856
references.citation: Ann Intern Med. 2010 May 4;152(9):578-89
references.pmid: 20439576
references.citation: N Engl J Med. 2015 Aug 20;373(8):697-704
references.pmid: 26095467
references.citation: J Thromb Haemost. 2011 Jan;9(1):79-84
references.pmid: 20946181
references.citation: Arch Intern Med. 1991 May;151(5):933-8
references.pmid: 2025141