title: Association of diethylhexyl phthalate with obesity-related markers and body mass change from birth to 3 months of age.
abstract: BACKGROUND
  Several studies have suggested potential links of phthalates to obesity in children and adults. Limited evidence, however, has been available for the relations between diethylhexyl phthalate (DEHP) and obesity-related markers or body mass change in early life.
  
  
  METHODS
  128 healthy pregnant women were recruited and, after delivery, their newborns' first urine and umbilical cord blood samples were collected. We measured urinary levels of two DEHP metabolites, mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP). We also measured the levels of leptin, total cholesterol and triglyceride (TG) in cord serum, and used them along with weight, length, head circumference and ponderal index (PI, 100 g/cm(3)) at birth, as obesity-related markers, and estimated the relations between DEHP metabolites and obesity-related markers using generalised linear models. For the evaluation of body mass increase by early life DEHP exposure, body mass index (BMI) z-score change during 3 months after birth by DEHP metabolites in the first urine samples of the newborns were evaluated using logistic regression.
  
  
  RESULTS
  DEHP exposure was associated with decrease of PI and increase of TG (PI, β=-0.11, p=0.070 and TG, β=0.14, p=0.027), especially for boys (PI, β=-0.13, p=0.021; and TG, β=0.19, p=0.025). Moreover, DEHP exposure was positively associated with body mass increase during 3 months after birth (change of BMI z-scores, OR=4.35, p=0.025).
  
  
  CONCLUSIONS
  Our findings suggest that DEHP exposure may affect body mass change in early life through changes of obesity-related markers.
authors.affiliation: Department of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Hyunkyung
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Jangwoo
authors.initials: J
authors.lastname: Lee
authors.affiliation: College of Medicine, Korea University, Seoul, Republic of Korea.
authors.forename: Geumjoon
authors.initials: G
authors.lastname: Cho
authors.affiliation: College of Medicine, Inha University, Incheon, Republic of Korea College of Medicine, Hallym University, Seoul, Republic of Korea.
authors.forename: Sooran
authors.initials: S
authors.lastname: Choi
authors.affiliation: College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
authors.forename: Gyuyeon
authors.initials: G
authors.lastname: Choi
authors.affiliation: Jeju National University School of Medicine, Jeju, Republic of Korea.
authors.forename: Su Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: College of Medicine, Korea University, Seoul, Republic of Korea.
authors.forename: So-Hee
authors.initials: SH
authors.lastname: Eun
authors.affiliation: College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
authors.forename: Eunsook
authors.initials: E
authors.lastname: Suh
authors.affiliation: College of Medicine, Hallym University, Seoul, Republic of Korea.
authors.forename: Sung Koo
authors.initials: SK
authors.lastname: Kim
authors.affiliation: College of Medicine, Korea University, Seoul, Republic of Korea.
authors.forename: Hai-Joong
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: College of Medicine, Korea University, Seoul, Republic of Korea.
authors.forename: Gun-Ha
authors.initials: GH
authors.lastname: Kim
authors.affiliation: College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
authors.forename: Jeong Jae
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Jeju National University School of Medicine, Jeju, Republic of Korea.
authors.forename: Young Don
authors.initials: YD
authors.lastname: Kim
authors.affiliation: College of Medicine, Yonsei University, Seoul, Republic of Korea.
authors.forename: Soyong
authors.initials: S
authors.lastname: Eom
authors.affiliation: Jeju National University School of Medicine, Jeju, Republic of Korea.
authors.forename: Seunghyo
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Marine Sciences and Convergent Technology, Hanyang University, Ansan, Republic of Korea.
authors.forename: Hyo-Bang
authors.initials: HB
authors.lastname: Moon
authors.affiliation: College of Natural Sciences, Soonchunhyang University, Asan, Republic of Korea.
authors.forename: Jeongim
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Kyungho
authors.initials: K
authors.lastname: Choi
authors.affiliation: College of Medicine, Hallym University, Seoul, Republic of Korea.
authors.forename: Sungjoo
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Sungkyoon
authors.initials: S
authors.lastname: Kim
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine*; D015992:Body Mass Index; D004051:Diethylhexyl Phthalate / Q000097:blood / Q000302:isolation & purification*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D009035:Mothers; D009765:Obesity; D010968:Plasticizers / Q000302:isolation & purification*
chemical_list: D015415:Biomarkers; D010968:Plasticizers; D004051:Diethylhexyl Phthalate
keywords: Biomonitoring; CHILD HEALTH; Environmental epidemiology
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