title: The Association of Endothelin-1 with Markers of Arterial Stiffness in Black South African Women: The SABPA Study.
abstract: Background. Limited data exist regarding endothelin-1 (ET-1), a vasoactive contributor in vascular tone, in a population subjected to early vascular deterioration. We compared ET-1 levels and explored its association with markers of arterial stiffness in black and white South Africans. Methodology. This cross-sectional substudy included 195 black (men: n = 99; women: n = 95) and 197 white (men: n = 99; women: n = 98) South Africans. Serum ET-1 levels were measured as well as markers of arterial stiffness (blood pressure, pulse wave velocity, and arterial compliance). ET-1 levels were higher in black men and white women compared to their counterparts after adjusting for C-reactive protein. In both single and partial (adjusting for body mass index and gamma glutamyl transferase) regression analyses ET-1 correlated with age, interleukin-6, high density lipoprotein cholesterol, systolic blood pressure, pulse pressure, and pulse wave velocity in black women. In multivariate regression analyses the independent association of ET-1 with systolic blood pressure (Adj. R (2) = 0.13; β = 0.28, p < 0.01) and pulse pressure (Adj. R (2) = 0.11; β = 0.27, p < 0.01) was confirmed in black women only. ET-1 additionally associated with interleukin-6 in black women (p < 0.01). Conclusion. Our result suggests that ET-1 and its link with subclinical arteriosclerosis are potentially driven by low-grade inflammation as depicted by the association with interleukin-6 in the black female cohort.
authors.affiliation: Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2531, South Africa.
authors.forename: Christine Susara
authors.identifier: 0000-0002-9773-0135
authors.initials: CS
authors.lastname: du Plooy
authors.affiliation: Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2531, South Africa.
authors.forename: Catharina Martha Cornelia
authors.identifier: 0000-0003-0138-3341
authors.initials: CM
authors.lastname: Mels
authors.affiliation: Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2531, South Africa; Medical Research Council, Research Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
authors.forename: Hugo Willem
authors.initials: HW
authors.lastname: Huisman
authors.affiliation: Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2531, South Africa.
authors.forename: Ruan
authors.initials: R
authors.lastname: Kruger
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