title: Expression of galectin-9 mRNA in hepatocellular carcinoma.
abstract: Liver cancer, with a very high prevalence, is one of the most common causes of death worldwide. Galectin-9, a semi-galactoside-binding protein, was demonstrated to be involved in the formation and metastasis processes of tumors such as breast cancer, and has significant impact on the development and prognosis of tumor. In this study, 90 cases of liver cancer patients who had liver cancer resection surgery treatment, were selected. Samples of liver cancer tissues and cancer-adjacent tissues from the surgery resection of liver cancer patients, which also confirmed by pathology after operation as specimens, were obtained to detect the expression level of Galectin-9 mRNA. The comparing results showed that there were significant differences between the expression of Galectin-9 mRNA in cancer-adjacent tissues and that in cancer tissues (P < 0.05), in terms of pathology differentiation, TNM, and recurrence transfer aspects. However, there were no obvious correlations with gender, age, the size of tumor, and HBsAg. The expression of Galectin-9 mRNA has a close relationship with pathological differentiation, TNM, and recurrence metastasis. Our data presented here provide theoretical basis for new target of liver cancer diagnosis as well as potential prognosis.
authors.affiliation: Department of Medical Laboratory, Taizhou University Medical School Taizhou 318000, Zhejiang, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Medical Laboratory, Taizhou University Medical School Taizhou 318000, Zhejiang, China.
authors.forename: Jiayu
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Medical Laboratory, Wenzhou Medical University Wenzhou 325035, Zhejiang, China.
authors.forename: Yanzi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pathology, School of Medicine Zhejiang University Hangzhou 310058, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D005260:Female; D037161:Galectins / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D037161:Galectins; C105032:LGALS9 protein, human; D012333:RNA, Messenger
keywords: Galectin-9 mRNA; cancer-adjacent tissues; expression; liver cancer tissues
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