title: Glomus tumor of uncertain malignant potential of the lung: a case report and review of literature.
abstract: Glomus tumor is an uncommon tumor usually presenting in the dermis. Rarely, it occurred in visceral organs including stomach, liver and long. The majority of glomus tumors were benign. Herein, we present a case of glomus tumor located in the left lobe of the lung in a 49 year-old Chinese male. An irregular mass measuring 3 cm was detected by imaging examination because of his suffering from cough, dyspnea and chest pain. Histologically, the tumor is composed predominantly of sheets of ovoid to round cells with clear border, pale cytoplasm and fine granular chromatin. The mitotic count was less than 5 per 50 HPF. The tumor focally invaded the surrounding normal bronchial and alveolar tissue. Immunohistochemical staining showed that the cells were diffusely positive for SMA, caldesmon, and vimentin. The Ki-67 proliferation index was approximately 20%. Based on morphologic features and the immunohistochemical profile, the tumor was consistent with glomus tumor of uncertain malignant potential.
authors.affiliation: Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China.
authors.forename: Peng-Zhi
authors.initials: PZ
authors.lastname: Wan
authors.affiliation: Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Han
authors.affiliation: Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China.
authors.forename: En-Hua
authors.initials: EH
authors.lastname: Wang
authors.affiliation: Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China.
authors.forename: Xu-Yong
authors.initials: XY
authors.lastname: Lin
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D049109:Cell Proliferation; D005918:Glomus Tumor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D011013:Pneumonectomy; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor
keywords: Glomus tumor; pulmonary neoplasm; uncertain malignant potential
references.citation: Am J Surg Pathol. 2001 Jan;25(1):1-12
references.pmid: 11145243
references.citation: Int J Clin Exp Pathol. 2015;8(7):8632-5
references.pmid: 26339447
references.citation: World J Surg Oncol. 2015;13:22
references.pmid: 25888833
references.citation: Diagn Pathol. 2012;7:174
references.pmid: 23227905
references.citation: Onco Targets Ther. 2015 Jul 28;8:1909-14
references.pmid: 26251614
references.citation: J Cardiothorac Surg. 2013;8:146
references.pmid: 23758949
references.citation: Cancer. 1982 Oct 15;50(8):1601-7
references.pmid: 6288219
references.citation: Int J Surg Pathol. 2015 May;23(3):181-8
references.pmid: 25614464
references.citation: World J Gastroenterol. 2010 Sep 28;16(36):4616-20
references.pmid: 20857536
references.citation: Ann Thorac Cardiovasc Surg. 2010 Apr;16(2):113-7
references.pmid: 20930664
references.citation: Int J Clin Exp Pathol. 2014;7(4):1438-48
references.pmid: 24817939
references.citation: Respirology. 2002 Dec;7(4):369-71
references.pmid: 12421247
references.citation: Diagn Pathol. 2015;10:112
references.pmid: 26187280
references.citation: Case Rep Pathol. 2012;2012:782304
references.pmid: 23050181