title: Effect of antibiotics on gut microbiota, glucose metabolism and body weight regulation: a review of the literature.
abstract: Gut bacteria are involved in a number of host metabolic processes and have been implicated in the development of obesity and type 2 diabetes in humans. The use of antibiotics changes the composition of the gut microbiota and there is accumulating evidence from observational studies for an association between exposure to antibiotics and development of obesity and type 2 diabetes. In the present paper, we review human studies examining the effects of antibiotics on body weight regulation and glucose metabolism and discuss whether the observed findings may relate to alterations in the composition and function of the gut microbiota.
authors.affiliation: Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.|The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
authors.forename: K H
authors.initials: KH
authors.lastname: Mikkelsen
authors.affiliation: The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
authors.forename: K H
authors.initials: KH
authors.lastname: Allin
authors.affiliation: Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.|The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
authors.forename: F K
authors.initials: FK
authors.lastname: Knop
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D001069:Appetite Regulation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000382:microbiology; D064806:Dysbiosis / Q000139:chemically induced* / Q000382:microbiology / Q000503:physiopathology; D004734:Energy Metabolism / Q000187:drug effects; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006801:Humans; D007333:Insulin Resistance; D008954:Models, Biological; D064887:Observational Studies as Topic; D050177:Overweight / Q000209:etiology* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: glucose metabolism; observational study; pharmaco-epidemiology; type 2 diabetes