title: Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus.
abstract: Recent evidence has shown a complex relationship between the gut microbiota, dietary nutrients, and cardiovascular disease (CVD). Trimethylamine-N-oxide (TMAO) production, initiated by the microbiota, has been associated with CVD events. We sought to test if this association exists in HIV-infected persons. After adjusting for aspirin use and CVD risk factors, HIV-infected men were more likely to have coronary stenosis in the second and third TMAO quartiles compared with the first quartile, but did not differ significantly in the fourth quartile. We found an inverted U-shaped association between TMAO levels and the presence of coronary artery stenosis among HIV-infected men.
authors.affiliation: *Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Departments of †Epidemiology; ‡Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; §Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; ‖Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrence, CA; ¶Department of Medicine, Northwestern University, Chicago, IL; and #Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
authors.forename: P Elliott
authors.initials: PE
authors.lastname: Miller
authors.forename: Sabina A
authors.initials: SA
authors.lastname: Haberlen
authors.forename: Todd T
authors.initials: TT
authors.lastname: Brown
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Margolick
authors.forename: Joseph A
authors.initials: JA
authors.lastname: DiDonato
authors.forename: Stanley L
authors.initials: SL
authors.lastname: Hazen
authors.forename: Mallory D
authors.initials: MD
authors.lastname: Witt
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Kingsley
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Palella
authors.forename: Matthew
authors.initials: M
authors.lastname: Budoff
authors.forename: Lisa P
authors.initials: LP
authors.lastname: Jacobson
authors.forename: Wendy S
authors.initials: WS
authors.lastname: Post
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Sears
mesh_terms: D023921:Coronary Stenosis / Q000453:epidemiology*; D000069196:Gastrointestinal Microbiome; D015658:HIV Infections / Q000453:epidemiology*; D015528:HIV Seroprevalence; D006801:Humans; D008297:Male; D008744:Methylamines / Q000378:metabolism*; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D008744:Methylamines; C005855:trimethyloxamine
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