title: Cellulose Buccoadhesive Film Bearing Glimepiride: Physicomechanical Characterization and Biophysics of Buccoadhesion.
abstract: The present study aimed to develop buccoadhesive film of glimepiride with unique combination of polymers and to investigate its effect(s) on physicomechanical parameters, drug-release, and permeation of films. Drug-polymer interaction was examined by FTIR and DSC analysis. Films were prepared by solvent casting technique and characterized for film strength (320 ± 8.5 g, 28.98 ± 2.00 mJ), buccoadhesive strength (28.8 ± 1.37 g, 3.04 ± 0.32 mJ), and tensile strength (260 ± 6.88 g, 18.00 ± 0.44 mJ) by new instrumental techniques. Increase in polymer concentration augmented zeta potential of polymeric matrix-mucin mixture and exhibited strong buccoadhesion (electrical theory). Buccoadhesion was also influenced by particle size (adsorption theory) and swelling (wetting theory). Erosion behavior of films was observed in swelling and SEM studies. Film GM4 exhibited 98 ± 2% in vitro drug release and 85 ± 8% ex vivo drug permeation in 12 h with controlled diffusion mechanism. Films were compatible with oral probiotic microorganisms. Stability studies revealed no significant (P < 0.05) variation in physicomechanical characteristics.
authors.affiliation: Indira Gandhi Institute of Pharmaceutical Sciences, IRC Village, Bhubaneswar, 751015, India.|CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, 226015, UP, India.
authors.forename: Jaya Gopal
authors.initials: JG
authors.lastname: Meher
authors.affiliation: Indira Gandhi Institute of Pharmaceutical Sciences, IRC Village, Bhubaneswar, 751015, India.
authors.forename: Magdaline
authors.initials: M
authors.lastname: Tarai
authors.affiliation: Indira Gandhi Institute of Pharmaceutical Sciences, IRC Village, Bhubaneswar, 751015, India.
authors.forename: Ansuman
authors.initials: A
authors.lastname: Patnaik
authors.affiliation: Indira Gandhi Institute of Pharmaceutical Sciences, IRC Village, Bhubaneswar, 751015, India.
authors.forename: Paresh
authors.initials: P
authors.lastname: Mishra
authors.affiliation: CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, 226015, UP, India. npyadav@gmail.com.
authors.forename: Narayan Prasad
authors.initials: NP
authors.lastname: Yadav
mesh_terms: D000268:Adhesiveness; D000278:Administration, Buccal; D000818:Animals; D001682:Biological Availability; D002482:Cellulose / Q000008:administration & dosage* / Q000737:chemistry*; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods; D006041:Goats; D009061:Mouth Mucosa / Q000378:metabolism*; D010316:Particle Size; D010539:Permeability; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry; D013453:Sulfonylurea Compounds / Q000008:administration & dosage* / Q000737:chemistry*; D013718:Tensile Strength
chemical_list: D011108:Polymers; D013453:Sulfonylurea Compounds; C057619:glimepiride; D002482:Cellulose
keywords: biophysics of buccoadhesion; buccoadhesive film; buccoadhesive strength; buccocompatibility; glimepiride