title: Effects of the physicochemical properties of gold nanostructures on cellular internalization.
abstract: Unique physicochemical properties of Au nanomaterials make them potential star materials in biomedical applications. However, we still know a little about the basic problem of what really matters in fabrication of Au nanomaterials which can get into biological systems, especially cells, with high efficiency. An understanding of how the physicochemical properties of Au nanomaterials affect their cell internalization is of significant interest. Studies devoted to clarify the functions of various properties of Au nanostructures such as size, shape and kinds of surface characteristics in cell internalization are under way. These fundamental investigations will give us a foundation for constructing Au nanomaterial-based biomedical devices in the future. In this review, we present the current advances and rationales in study of the relationship between the physicochemical properties of Au nanomaterials and cell uptake. We also provide a perspective on the Au nanomaterial-cell interaction research.
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China;
authors.forename: Ningqiang
authors.initials: N
authors.lastname: Gong
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China and.
authors.forename: Shizhu
authors.initials: S
authors.lastname: Chen
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China;
authors.forename: Shubin
authors.initials: S
authors.lastname: Jin
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China and.
authors.forename: Jinchao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Laboratory of Molecular Imaging, Department of Radiology, Howard University, Washington, DC 20060, USA.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China;
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
keywords: cellular internalization; gold nanostructures; size, shape; surface chemistry
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