title: Clinical Applications for Immunohistochemistry of Breast Lesions.
abstract: Immunohistochemical analysis has been a key clinical tool that shows the protein expression of molecular markers. Expression of molecular markers in breast pathology has been used to distinguish breast cancers from benign lesions, classify subtypes of breast cancers, and determine therapeutic intervention. It is a relatively fast and efficient option in stratifying breast lesions to assist in both determining pathology diagnosis and offer strategies to the best course of clinical action. In this chapter, we discuss the use of immunohistochemistry testing for some of the key molecular markers involved in breast pathology that are crucial for classifying breast cancers and the guidelines for the interpretation of testing results that assist in clinical management.
authors.affiliation: Department of Pathology, Stony Brook University Hospital, Stony Brook, NY, USA.
authors.forename: Kester
authors.initials: K
authors.lastname: Haye
authors.affiliation: Department of Pathology, Stony Brook University Hospital, Stony Brook, NY, USA.
authors.forename: Rajarsi
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Department of Pathology, Stony Brook University Hospital, Stony Brook, NY, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Metter
authors.affiliation: Associate Professor of Pathology, Department of Pathology, Stony Brook University Hospital, Stony Brook, NY, 11794-7025, USA. Jingxuan.Liu@stonybrookmedicine.edu.
authors.forename: Jingxuan
authors.initials: J
authors.lastname: Liu
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D004801:Eosine Yellowish-(YS) / Q000378:metabolism; D005260:Female; D006416:Hematoxylin / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D013194:Staining and Labeling
chemical_list: D004801:Eosine Yellowish-(YS); D006416:Hematoxylin
keywords: Cytokeratin; E-cadherin; ER; HER2; Immunohistochemistry; Ki-67; Myoepithelial cells; PR