title: Primary alveolar soft part sarcoma of uterine corpus: a case report with immunohistochemical, ultrastructural study and review of literature.
abstract: BACKGROUND
  Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignancy. ASPS usually occurs most commonly in the deep soft tissues of the thigh and buttock or the head and neck regions. ASPS that originate from the uterine corpus are even more rare, with only 10 previous cases reported in the English literature.
  
  
  METHODS
  In our case, the alveolar features were completely lost and the tumour shows a solid, non-alveolar pattern and the nuclei have marked variation in nuclear size, and multinucleation. The correct pathological diagnosis has been made by immuno- histochemical and ultrastructural features, which rvealed overexpression of TFE3 and peculiar cytoplasmic crystalline inclusions. In this paper, an additional case of primary ASPS of uterine corpus is reported with immunohistochemical, ultrastructural study and review of literature in the effort to delineate its clinical and pathological features. In this unusual site, the diagnosis can be problematic because ASPS can mimic other primary or metastatic uterine neoplasms.
  
  
  CONCLUSIONS
  Thus, in this unusual presentation an essential diagnostic marker is the nuclear over-expression of TFE3 as well as ultrastructural study, which reveals the presence of peculiar cytoplasmic crystalline inclusions.
authors.affiliation: Department of Biomedical, Biotechnological and Translational Sciences, Pathological Anatomy and Histology Unit, Faculty of Medicine, University of Parma, Via Antonio Gramsci, 14, 43126, Parma, Italy. giovanna.giordano@unipr.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Giordano
authors.affiliation: Department of Biomedical, Biotechnological and Translational Sciences, Pathological Anatomy and Histology Unit, Faculty of Medicine, University of Parma, Via Antonio Gramsci, 14, 43126, Parma, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: D'Adda
authors.affiliation: Department of Biomedical, Biotechnological and Translational Sciences, Pathological Anatomy and Histology Unit, Faculty of Medicine, University of Parma, Via Antonio Gramsci, 14, 43126, Parma, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Varotti
authors.affiliation: Department of Gynaecology and Obstetrics, Hospital of Fidenza, Parma, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Crovini
authors.affiliation: Department of Biomedical, Biotechnological and Translational Sciences, Pathological Anatomy and Histology Unit, Faculty of Medicine, University of Parma, Via Antonio Gramsci, 14, 43126, Parma, Italy.
authors.forename: Enrico Maria
authors.initials: EM
authors.lastname: Silini
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D011379:Prognosis; D018234:Sarcoma, Alveolar Soft Part / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D014408:Biomarkers, Tumor
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