title: The changing face of liver transplantation for acute liver failure: Assessment of current status and implications for future practice.
abstract: The etiology and outcomes of acute liver failure (ALF) have changed since the definition of this disease entity in the 1970s. In particular, the role of emergency liver transplantation has evolved over time, with the development of prognostic scoring systems to facilitate listing of appropriate patients, and a better understanding of transplant benefit in patients with ALF. This review examines the changing etiology of ALF, transplant benefit, outcomes following transplantation, and future alternatives to emergency liver transplantation in this devastating condition.
authors.affiliation: Department of Hepatology, Division of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom.|Scottish Liver Transplantation Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
authors.forename: Mhairi C
authors.initials: MC
authors.lastname: Donnelly
authors.affiliation: Department of Hepatology, Division of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom.|Scottish Liver Transplantation Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Hayes
authors.affiliation: Department of Hepatology, Division of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom.|Scottish Liver Transplantation Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Simpson
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects; D000111:Acetylcysteine / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy; D000075202:Contraindications; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D017114:Liver Failure, Acute / Q000188:drug therapy / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000639:trends*; D011379:Prognosis; D011788:Quality of Life; D035583:Rare Diseases / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome; D014850:Waiting Lists / Q000401:mortality
chemical_list: D018712:Analgesics, Non-Narcotic; D016166:Free Radical Scavengers; D000082:Acetaminophen; D000111:Acetylcysteine