title: Comparison of Warm Blood Cardioplegia Delivery With or Without the Use of a Roller Pump.
abstract: Various techniques for administration of blood cardioplegia are used worldwide. In this study, the effect of warm blood cardioplegia administration with or without the use of a roller pump on perioperative myocardial injury was studied in patients undergoing coronary artery bypass grafting using minimal extra-corporeal circuits (MECCs). Sixty-eight patients undergoing elective coronary bypass surgery with an MECC system were consecutively enrolled and randomized into a pumpless group (PL group: blood cardioplegia administration without roller pump) or roller pump group (RP group: blood cardioplegia administration with roller pump). No statistically significant differences were found between the PL group and RP group regarding release of cardiac biomarkers. Maximum postoperative biomarker values reached at T1 (after arrival intensive care unit) for heart-type fatty acid binding protein (2.7 [1.5; 6.0] ng/mL PL group vs. 3.2 [1.6; 6.3] ng/mL RP group, p = .63) and at T3 (first postoperative day) for troponin T high-sensitive (22.0 [14.5; 29.3] ng/L PL group vs. 21.1 [15.3; 31.6] ng/L RP group, p = .91), N-terminal pro-brain natriuretic peptide (2.1 [1.7; 2.9] ng/mL PL group vs. 2.6 [1.6; 3.6] ng/mL RP group, p = .48), and C-reactive protein (138 [106; 175] μg/mL PL group vs. 129 [105; 161] μg/mL RP group, p = .65). Besides this, blood cardioplegia flow, blood cardioplegia line pressure, and aortic root pressure during blood cardioplegia administration were similar between the two groups. Administration of warm blood cardioplegia with or without the use of a roller pump results in similar clinically acceptable myocardial protection.
authors.affiliation: Department of Extracorporeal Circulation, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Mizja M
authors.initials: MM
authors.lastname: Faber
authors.affiliation: Department of Anaesthesiology, Intensive Care and Pain Management, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Noordzij
authors.affiliation: Department of Anaesthesiology, Intensive Care and Pain Management, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Simon
authors.initials: S
authors.lastname: Hennink
authors.affiliation: Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Hans
authors.initials: H
authors.lastname: Kelder
authors.affiliation: Department of Extracorporeal Circulation, Haga Hospital, The Hague, The Netherlands.
authors.forename: Roel
authors.initials: R
authors.lastname: de Vroege
authors.affiliation: Department of Extracorporeal Circulation, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Frans G
authors.initials: FG
authors.lastname: Waanders
authors.affiliation: Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Edgar
authors.initials: E
authors.lastname: Daeter
authors.affiliation: Department of Extracorporeal Circulation, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Marco C
authors.initials: MC
authors.lastname: Stehouwer
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D001026:Coronary Artery Bypass / Q000379:methods*; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D005260:Female; D006324:Heart Arrest, Induced / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D020107:Troponin T; D002097:C-Reactive Protein
keywords: coronary artery bypass grafting; myocardial injury; myocardial protection; warm blood cardioplegia
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