title: A delayed injection-site reaction in a patient receiving extended-release naltrexone.
abstract: Pharmacotherapy, such as oral naltrexone, has proven effective in treating alcohol use disorder, although medication adherence has presented challenges. Although a formulation of extended-release naltrexone for intramuscular injection has been developed to counter daily adherence issues, injection-site reactions can occur within days of depot injection.
  
  
  
  The authors report a case of an individual with alcohol use disorder who had a previously undescribed delayed injection-site reaction that occurred 11 days after injection. Subsequent challenge with the medication resulted in recurrence of the reaction.
  
  
  
  Although extended-release naltrexone is generally well tolerated, injection-site reactions can complicate treatment and can appear more than 10 days after medication administration.
authors.affiliation: a British Columbia Centre for Excellence in HIV/AIDS , St. Paul's Hospital, Vancouver , British Columbia , Canada.|b Department of Family Medicine , University of British Columbia , Vancouver , British Columbia , Canada.|c Department of Family and Community Medicine , Providence Health Care , Vancouver , British Columbia , Canada.
authors.forename: Keith
authors.initials: K
authors.lastname: Ahamad
authors.affiliation: d Department of Medicine , Oregon Health and Science University , Portland , Oregon , USA.|e Department of Public Health-Preventive Medicine , Oregon Health and Science University , Portland , Oregon , USA.
authors.forename: P Todd
authors.initials: PT
authors.lastname: Korthuis
authors.affiliation: f Positive Health Program, HIV/AIDS Division, University of California , San Francisco , California , USA.
authors.forename: Paula J
authors.initials: PJ
authors.lastname: Lum
authors.affiliation: a British Columbia Centre for Excellence in HIV/AIDS , St. Paul's Hospital, Vancouver , British Columbia , Canada.
authors.forename: Cheyenne
authors.initials: C
authors.lastname: Johnson
authors.affiliation: a British Columbia Centre for Excellence in HIV/AIDS , St. Paul's Hospital, Vancouver , British Columbia , Canada.|g Department of Medicine , University of British Columbia , Vancouver , British Columbia , Canada.
authors.forename: Evan
authors.initials: E
authors.lastname: Wood
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D000075662:Injection Site Reaction; D007273:Injections, Intramuscular / Q000009:adverse effects*; D008297:Male; D009271:Naltrexone / Q000008:administration & dosage*; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D009292:Narcotic Antagonists; D009271:Naltrexone
keywords: Alcohol use disorder; extended-release naltrexone; injection-site reaction
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