title: Smooth pursuit eye movements in patients with macular degeneration.
abstract: Currently, there are no quantitative studies of smooth pursuit, a behavior attributed to the fovea, in individuals with macular degeneration (MD). We hypothesize that pursuit in MD patients depends on the relative positions of the scotoma and target trajectory. We tested this hypothesis with a scanning laser ophthalmoscope (SLO), which allows for direct visualization of the target on the damaged retina. Monocular microperimetry and eye movements were assessed in eleven individuals with differing degrees of MD. Observers were asked to visually track a 1.7° target that moved in one of eight radial directions at 5°/s-6°/s. Consistent with our hypothesis, pursuit metrics depended on whether the target moved into or out of scotoma. Pursuit gains decreased with increasing scotoma extent in the target's heading direction (p = 0.017). Latencies were higher when the scotoma was present along the target trajectory (in either starting or heading directions, p < 0.001). Furthermore, an analysis of retinal position shows that targets fell on the fixational locus nearly 50% of the time. The results suggest that MD patients are capable of smooth pursuit eye movements, but are limited by target trajectory and scotoma characteristics.
authors.forename: Natela
authors.initials: N
authors.lastname: Shanidze
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fusco
authors.forename: Elena
authors.initials: E
authors.lastname: Potapchuk
authors.forename: Stephen
authors.initials: S
authors.lastname: Heinen
authors.forename: Preeti
authors.initials: P
authors.lastname: Verghese
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D011698:Pursuit, Smooth / Q000502:physiology*; D012607:Scotoma / Q000503:physiopathology; D058609:Visual Field Tests
references.citation: Vision Res. 1992 Feb;32(2):365-73
references.pmid: 1574851
references.citation: J Vis. 2015;15(5):7
references.pmid: 26067525
references.citation: Ophthalmology. 2003 Jan;110(1):65-9
references.pmid: 12511348
references.citation: Vision Res. 2004;44(13):1537-46
references.pmid: 15126063
references.citation: Vision Res. 1978;18(9):1165-72
references.pmid: 716236
references.citation: Vision Res. 1983;23(12):1573-83
references.pmid: 6666059
references.citation: Invest Ophthalmol Vis Sci. 1988 Feb;29(2):268-78
references.pmid: 3338884
references.citation: Annu Rev Neurosci. 1987;10:97-129
references.pmid: 3551767
references.citation: Exp Brain Res. 1985;57(3):562-75
references.pmid: 3979498
references.citation: Invest Ophthalmol Vis Sci. 1990 Jun;31(6):1149-61
references.pmid: 2354915
references.citation: J Physiol. 1961 Dec;159:326-38
references.pmid: 14490422
references.citation: Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2886-96
references.pmid: 16043863
references.citation: J Vis. 2005;5(6):493-503
references.pmid: 16097862
references.citation: Invest Ophthalmol Vis Sci. 2006 Jan;47(1):169-78
references.pmid: 16384959
references.citation: Exp Brain Res. 2006 Oct;175(1):1-10
references.pmid: 16761137
references.citation: Ophthalmology. 1997 Apr;104(4):632-8
references.pmid: 9111255
references.citation: J Opt Soc Am A Opt Image Sci Vis. 2007 May;24(5):1402-10
references.pmid: 17429486
references.citation: J Rehabil Res Dev. 1999 Oct;36(4):294-302
references.pmid: 10678452