title: Double faced role of human mesenchymal stem cells and their role challenges in cancer therapy.
abstract: Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, these cells may undergo spontaneous transformation leading to them bypassing naturally built-in cell controls that could lead to senescence and carcinogenesis. Therefore, although MSCs have great potential for cancer therapy, they also risk the development of cancer, which provides them with double-faced characteristics for both cancer development and therapy. The potential use of hMSCs in therapeutics from the aspect of in vitro expansion of hMSCs and telomere dynamic is discussed.
authors.affiliation: Faculty of Medicine, Department of Medical Genetics, Near East University, Yakin Dogu Bulvari, Nicosia, Cyprus, Turkey. nedimeserakinci@gmail.com pintulay@gmail.com.
authors.forename: Nedime
authors.initials: N
authors.lastname: Serakinci
authors.forename: Rasime
authors.initials: R
authors.lastname: Kalkan
authors.forename: Pinar
authors.initials: P
authors.lastname: Tulay
mesh_terms: D063646:Carcinogenesis / Q000235:genetics* / Q000473:pathology; D002454:Cell Differentiation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D016922:Cellular Senescence / Q000235:genetics; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects*; D059630:Mesenchymal Stem Cells / Q000473:pathology; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D016615:Telomere / Q000235:genetics