title: Prevalence of metabolic syndrome as per the NCEP and IDF definitions vis-a-vis severity and duration of psoriasis in a semi-urban Maharashtrian population: A case control study.
abstract: BACKGROUND
  The inexorable inflammation in patients of psoriasis predisposes to various disorders, notably, a cluster of cardiovascular and metabolic abnormalities christened 'metabolic syndrome'.
  
  
  OBJECTIVE
  To assess the prevalence of metabolic syndrome and its correlation with the severity and duration of psoriasis.
  
  
  METHODS
  One hundred psoriasis patients and 100 age-and-sex matched controls were included, whose waist circumference and blood pressure were measured; fasting serum cholesterol, triglycerides and glucose levels quantified; disease severity assessed and metabolic syndrome defined separately by two globally accepted criteria.
  
  
  RESULTS
  Metabolic syndrome (38%:12%), hypertriglyceridemia (53%:25%), impaired glucose tolerance (38%:16%) [P<0.001] and low HDL (P=0.002) were significantly more prevalent in cases as compared to controls as were the mean values of triglycerides and fasting blood sugar. Increased mean age of psoriasis patients and duration of disease strongly correlated with the presence of this syndrome. The divergence in definition of the syndrome by two separate criteria was also highly significant (P<0.001).
  
  
  CONCLUSIONS
  Metabolic syndrome had significant presence in and increased with the duration but remained unaffected by the severity of psoriasis in our study patients.
authors.affiliation: Dermatology department, Dr. D.Y. Patil Medical College, Hospital & Research Centre, Pimpri, Pune, India.
authors.forename: Yugal K
authors.initials: YK
authors.lastname: Sharma
authors.affiliation: Dermatology department, Dr. D.Y. Patil Medical College, Hospital & Research Centre, Pimpri, Pune, India. Electronic address: drnarenprakash@gmail.com.
authors.forename: Naren
authors.initials: N
authors.lastname: Prakash
authors.affiliation: Dermatology department, Dr. D.Y. Patil Medical College, Hospital & Research Centre, Pimpri, Pune, India.
authors.forename: Aayush
authors.initials: A
authors.lastname: Gupta
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D011565:Psoriasis / Q000150:complications* / Q000473:pathology; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol
keywords: Diabetes; Dyslipidemia; Metabolic syndrome; Obesity; Psoriasis