title: Cesium-131 brachytherapy in high risk and recurrent head and neck cancers: first report of long-term outcomes.
abstract: OBJECTIVE
  The feasibility and efficacy of re-irradiation using contemporary radiation techniques to treat recurrent head and neck cancer has been demonstrated but the role of brachytherapy is unclear. Here we describe the use of (131)Cs brachytherapy with concurrent salvage surgery in 18 patients.
  
  
  METHODS
  Eligible patients underwent maximal gross resection of the tumor with implantation of brachytherapy seeds delivering a minimum dose of 80 Gy to the tumor bed. Rates of overall survival, locoregional progression free survival, disease-free survival, and radiation-induced toxicity were analyzed.
  
  
  RESULTS
  Retrospective Kaplan-Meier analysis shows median overall survival was 15 months and disease free survival was 12 months. Two patients developed grade 3 toxicity; all other complications were grade 1-2 with no grade 4 or 5 complications.
  
  
  CONCLUSIONS
  Compared to prior literature, our study shows comparable rates of survival with a decreased rate of radiation-induced toxicity.
authors.affiliation: Weill Cornell Medical College, New York, NY.
authors.forename: Anthony
authors.initials: A
authors.lastname: Pham
authors.affiliation: Weill Cornell Medical College, New York, NY.
authors.forename: Shruthi
authors.initials: S
authors.lastname: Arora
authors.affiliation: Weill Cornell Medical College, New York, NY; Stich Radiation Center, New York-Presbyterian/Weill Cornell Medical Center, New York, NY.
authors.forename: A Gabriella
authors.initials: AG
authors.lastname: Wernicke
authors.affiliation: Division of Otolaryngology, New York-Presbyterian/Weill Cornell Medical Center, New York, NY, USA.
authors.forename: David I
authors.initials: DI
authors.lastname: Kutler
authors.affiliation: Division of Otolaryngology, New York-Presbyterian/Weill Cornell Medical Center, New York, NY, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Cohen
authors.affiliation: Division of Otolaryngology, New York-Presbyterian/Weill Cornell Medical Center, New York, NY, USA.
authors.forename: William
authors.initials: W
authors.lastname: Kuhel
authors.affiliation: Weill Cornell Medical College, New York, NY.
authors.forename: Samuel
authors.initials: S
authors.lastname: Trichter
authors.affiliation: Weill Cornell Medical College, New York, NY.
authors.forename: Dattatreyudu
authors.initials: D
authors.lastname: Nori
authors.affiliation: Weill Cornell Medical College, New York, NY.
authors.forename: Silvia C
authors.initials: SC
authors.lastname: Formenti
authors.affiliation: Weill Cornell Medical College, New York, NY.
authors.forename: Bhupesh
authors.initials: B
authors.lastname: Parashar
keywords: 131Cs; brachytherapy; head and neck cancer; recurrence
references.citation: Head Neck. 2008 Mar;30(3):281-8
references.pmid: 17764087
references.citation: Cancer. 2001 Jun 1;91(11):2071-6
references.pmid: 11391587
references.citation: J Surg Oncol. 1982 Mar;19(3):136-8
references.pmid: 7070092
references.citation: J Clin Oncol. 2006 Jun 10;24(17):2653-8
references.pmid: 16763279
references.citation: Brachytherapy. 2014 Mar-Apr;13(2):187-95
references.pmid: 24211123
references.citation: Laryngoscope. 2010 Feb;120(2):267-72
references.pmid: 20013840
references.citation: J Clin Oncol. 2007 Oct 20;25(30):4800-5
references.pmid: 17947728
references.citation: Int J Radiat Oncol Biol Phys. 2001 Oct 1;51(2):354-62
references.pmid: 11567809
references.citation: Brachytherapy. 2003;2(3):158-63
references.pmid: 15062138
references.citation: Laryngoscope. 1991 Apr;101(4 Pt 1):405-10
references.pmid: 1895857
references.citation: Radiat Oncol. 2010 Jul 30;5:68
references.pmid: 20673340
references.citation: Am J Surg. 1976 Oct;132(4):504-7
references.pmid: 1015542
references.citation: Int J Radiat Oncol Biol Phys. 1995 Jun 15;32(3):605-9
references.pmid: 7790245
references.citation: Cancer. 2007 May 15;109(10):2052-7
references.pmid: 17407106
references.citation: Curr Opin Otolaryngol Head Neck Surg. 2008 Apr;16(2):135-40
references.pmid: 18327032
references.citation: Ann Oncol. 2004 Aug;15(8):1179-86
references.pmid: 15277256
references.citation: Brachytherapy. 2012 Mar-Apr;11(2):137-43
references.pmid: 22104354
references.citation: J Clin Oncol. 2008 Dec 1;26(34):5518-23
references.pmid: 18936479
references.citation: Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1444-50
references.pmid: 16029806
references.citation: Int J Radiat Oncol Biol Phys. 2004 May 1;59(1):72-7
references.pmid: 15093901
references.citation: Laryngoscope. 2002 Aug;112(8 Pt 1):1366-71
references.pmid: 12172246
references.citation: Cancer. 1981 Feb 1;47(3):496-502
references.pmid: 7226001
references.citation: Head Neck. 2006 Oct;28(10):888-95
references.pmid: 16721742
references.citation: Int J Radiat Oncol Biol Phys. 2009 Aug 1;74(5):1342-7
references.pmid: 19135312
references.citation: Otolaryngol Head Neck Surg. 2007 Jan;136(1):98-103
references.pmid: 17210342
references.citation: Brachytherapy. 2015 Jul-Aug;14(4):565-70
references.pmid: 25920811
references.citation: Laryngoscope. 2008 Aug;118(8):1362-71
references.pmid: 18496152
references.citation: Head Neck. 2001 Sep;23(9):791-8
references.pmid: 11505491
references.citation: N Engl J Med. 2004 May 6;350(19):1937-44
references.pmid: 15128893
references.citation: Arch Otolaryngol Head Neck Surg. 2003 Dec;129(12):1317-21
references.pmid: 14676158
references.citation: Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):382-91
references.pmid: 16213104
references.citation: Am J Surg. 1985 Oct;150(4):485-7
references.pmid: 4051112
references.citation: World J Surg Oncol. 2013 Mar 08;11:60
references.pmid: 23496973
references.citation: J Surg Oncol. 1974;6(5):357-80
references.pmid: 4610285
references.citation: Head Neck. 2003 Nov;25(11):953-9
references.pmid: 14603456
references.citation: Mcgill J Med. 2011 Jun;13(2):29
references.pmid: 22363192
references.citation: Brachytherapy. 2011 Nov-Dec;10(6):508-13
references.pmid: 21640663
references.citation: N Engl J Med. 2004 May 6;350(19):1945-52
references.pmid: 15128894
references.citation: N Engl J Med. 2008 Sep 11;359(11):1116-27
references.pmid: 18784101
references.citation: Int J Radiat Oncol Biol Phys. 2001 Aug 1;50(5):1190-8
references.pmid: 11483328
references.citation: Head Neck. 2006 Feb;28(2):107-13
references.pmid: 16388526
references.citation: Brachytherapy. 2007 Apr-Jun;6(2):157-63
references.pmid: 17434110
references.citation: Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):731-40
references.pmid: 17379449
references.citation: Laryngoscope. 2000 Mar;110(3 Pt 2 Suppl 93):1-18
references.pmid: 10714711
references.citation: Brachytherapy. 2013 Jan-Feb;12(1):1-7
references.pmid: 23167979
references.citation: Int J Radiat Oncol Biol Phys. 2001 Dec 1;51(5):1305-12
references.pmid: 11728691
references.citation: Head Neck. 1996 May-Jun;18(3):229-35
references.pmid: 8860763
references.citation: Int J Radiat Oncol Biol Phys. 2000 Jul 15;47(5):1311-21
references.pmid: 10889385
references.citation: Curr Opin Oncol. 1998 May;10(3):207-12
references.pmid: 9619356