title: Feedback Regulation of Kinase Signaling Pathways by AREs and GREs.
abstract: In response to environmental signals, kinases phosphorylate numerous proteins, including RNA-binding proteins such as the AU-rich element (ARE) binding proteins, and the GU-rich element (GRE) binding proteins. Posttranslational modifications of these proteins lead to a significant changes in the abundance of target mRNAs, and affect gene expression during cellular activation, proliferation, and stress responses. In this review, we summarize the effect of phosphorylation on the function of ARE-binding proteins ZFP36 and ELAVL1 and the GRE-binding protein CELF1. The networks of target mRNAs that these proteins bind and regulate include transcripts encoding kinases and kinase signaling pathways (KSP) components. Thus, kinase signaling pathways are involved in feedback regulation, whereby kinases regulate RNA-binding proteins that subsequently regulate mRNA stability of ARE- or GRE-containing transcripts that encode components of KSP.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. vlaso001@umn.edu.|Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA. vlaso001@umn.edu.
authors.forename: Irina
authors.initials: I
authors.lastname: Vlasova-St Louis
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. bohja001@umn.edu.|Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, MN 55455, USA. bohja001@umn.edu.|Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA. bohja001@umn.edu.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Bohjanen
keywords: ARE- GRE- mRNA stability; CELF1; ELAVL1; ZFP36; kinase signaling; posttranscriptional gene regulation
references.citation: Nucleic Acids Res. 2002 Dec 15;30(24):5529-38
references.pmid: 12490721
references.citation: Biochim Biophys Acta. 2011 Sep;1813(9):1619-33
references.pmid: 21167873
references.citation: Mol Syst Biol. 2009;5:288
references.pmid: 19638969
references.citation: World J Biol Chem. 2013 Nov 26;4(4):111-8
references.pmid: 24340134
references.citation: J Immunol. 2015 Jul 1;195(1):265-76
references.pmid: 26002976
references.citation: Ann Neurol. 2011 Apr;69(4):681-90
references.pmid: 21400563
references.citation: Mech Ageing Dev. 2010 May;131(5):306-14
references.pmid: 20219523
references.citation: RNA Biol. 2014;11(10):1250-61
references.pmid: 25584704
references.citation: PLoS Genet. 2012 Sep;8(9):e1002977
references.pmid: 23028373
references.citation: PLoS One. 2012;7(3):e33194
references.pmid: 22413002
references.citation: PLoS One. 2012;7(3):e33431
references.pmid: 22428049
references.citation: Mol Cell. 2007 Feb 23;25(4):543-57
references.pmid: 17317627
references.citation: Physiol Rev. 2012 Apr;92(2):689-737
references.pmid: 22535895
references.citation: Structure. 2010 Oct 13;18(10):1364-77
references.pmid: 20947024
references.citation: J Biol Chem. 2006 Oct 27;281(43):32806-19
references.pmid: 16931514
references.citation: J Biol Chem. 2007 Feb 9;282(6):3766-77
references.pmid: 17170118
references.citation: J Immunol. 2005 Jan 15;174(2):953-61
references.pmid: 15634918
references.citation: Nucleic Acids Res. 2008 Jan;36(Database issue):D137-40
references.pmid: 17984078
references.citation: J Biol Chem. 2010 Aug 13;285(33):25196-202
references.pmid: 20554520
references.citation: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D111-4
references.pmid: 16381826
references.citation: Biochem Pharmacol. 2014 Jun 15;89(4):431-40
references.pmid: 24735612
references.citation: Mol Cell. 2011 Aug 5;43(3):327-39
references.pmid: 21723170
references.citation: Genes Dev. 2007 Mar 15;21(6):719-35
references.pmid: 17369404
references.citation: Mol Cell Biol. 2009 Aug;29(16):4341-51
references.pmid: 19528229
references.citation: Mol Pharmacol. 2015 Apr;87(4):629-38
references.pmid: 25429052
references.citation: PLoS One. 2010 Jun 21;5(6):e11201
references.pmid: 20574513
references.citation: FEBS J. 2005 May;272(9):2118-31
references.pmid: 15853797
references.citation: Nucleic Acids Res. 2011 Jan;39(Database issue):D66-9
references.pmid: 21071424
references.citation: Mol Cell Biol. 2008 Apr;28(8):2608-25
references.pmid: 18285462
references.citation: J Biol Chem. 2012 Jan 6;287(2):950-60
references.pmid: 22117072
references.citation: J Cell Biochem. 2007 Apr 15;100(6):1477-92
references.pmid: 17133347
references.citation: Mol Cell. 2011 Aug 5;43(3):340-52
references.pmid: 21723171
references.citation: Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6858-63
references.pmid: 20351266
references.citation: Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13221-6
references.pmid: 9371827
references.citation: Nucleic Acids Res. 2013 Aug;41(14):7153-66
references.pmid: 23748565
references.citation: Mol Biol Cell. 2007 Jun;18(6):2137-48
references.pmid: 17392515
references.citation: Wiley Interdiscip Rev Syst Biol Med. 2010 Mar-Apr;2(2):162-80
references.pmid: 20836020
references.citation: Front Biosci (Landmark Ed). 2015 Jun 01;20:1250-8
references.pmid: 25961555
references.citation: J Biol Chem. 2005 May 27;280(21):20549-57
references.pmid: 15788409
references.citation: EMBO J. 1998 Jun 15;17(12):3461-70
references.pmid: 9628881
references.citation: Genomics. 2004 Dec;84(6):1002-13
references.pmid: 15533717
references.citation: Mol Cell Biol. 2010 Mar;30(6):1397-410
references.pmid: 20086103
references.citation: Carcinogenesis. 2011 May;32(5):676-85
references.pmid: 21310943
references.citation: Curr Genomics. 2010 Apr;11(2):77-90
references.pmid: 20885816
references.citation: Mol Cell Biol. 2004 May;24(9):3682-91
references.pmid: 15082764
references.citation: Am J Physiol Cell Physiol. 2011 Sep;301(3):C609-18
references.pmid: 21593445
references.citation: Mol Cell Biol. 2011 Jan;31(2):256-66
references.pmid: 21078877
references.citation: J Biol Chem. 2009 Apr 24;284(17):11216-23
references.pmid: 19258311
references.citation: Cell Cycle. 2008 Nov 1;7(21):3371-7
references.pmid: 18948743
references.citation: PLoS One. 2011;6(5):e20254
references.pmid: 21637851
references.citation: J Interferon Cytokine Res. 2014 Apr;34(4):233-41
references.pmid: 24697201
references.citation: J Immunol. 2015 Oct 1;195(7):2963-71
references.pmid: 26386038
references.citation: J Biol Chem. 2001 Mar 16;276(11):7820-6
references.pmid: 11124939
references.citation: J Cancer Res Clin Oncol. 2015 Apr;141(4):671-89
references.pmid: 25146530
references.citation: Curr Opin Genet Dev. 2013 Feb;23(1):35-43
references.pmid: 23312841
references.citation: FASEB J. 2010 Oct;24(10):3706-19
references.pmid: 20479119
references.citation: Front Biosci (Landmark Ed). 2012 Jan 01;17:189-205
references.pmid: 22201738
references.citation: Biochem Pharmacol. 2010 Dec 15;80(12):1915-20
references.pmid: 20599781
references.citation: Biochem Soc Trans. 2008 Jun;36(Pt 3):491-6
references.pmid: 18481987
references.citation: J Cell Physiol. 2011 Jan;226(1):276-84
references.pmid: 20665674
references.citation: Wiley Interdiscip Rev RNA. 2012 Sep-Oct;3(5):719-31
references.pmid: 22733578
references.citation: Nat Rev Immunol. 2014 Jun;14(6):361-76
references.pmid: 24854588
references.citation: Genome Biol. 2014 Jan 08;15(1):R12
references.pmid: 24401661
references.citation: Mol Cell Biol. 2003 Oct;23(20):7177-88
references.pmid: 14517288
references.citation: J Biol Chem. 2001 Dec 21;276(51):47958-65
references.pmid: 11602610
references.citation: Nucleic Acids Res. 2009 Aug;37(15):5151-66
references.pmid: 19553194
references.citation: PLoS Genet. 2009 Aug;5(8):e1000600
references.pmid: 19680539
references.citation: J Nucleic Acids. 2010 Jul 25;2010:null
references.pmid: 20798862
references.citation: J Clin Invest. 2009 Dec;119(12):3797-806
references.pmid: 19907076
references.citation: J Autoimmun. 2006 May;26(3):182-96
references.pmid: 16546352
references.citation: Nat Immunol. 2014 Sep;15(9):808-14
references.pmid: 25137455
references.citation: Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):666-79
references.pmid: 23428348
references.citation: J Biol Chem. 2013 Dec 6;288(49):35372-86
references.pmid: 24151077
references.citation: Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R518-30
references.pmid: 22170620
references.citation: Genes Dev. 2015 Oct 1;29(19):2054-66
references.pmid: 26443849
references.citation: J Biol Chem. 2003 May 30;278(22):19947-55
references.pmid: 12639954
references.citation: Wiley Interdiscip Rev RNA. 2012 Jan-Feb;3(1):104-21
references.pmid: 22180311
references.citation: Trends Biochem Sci. 1995 Nov;20(11):465-70
references.pmid: 8578590
references.citation: Mol Cell Biol. 2010 Aug;30(16):3970-80
references.pmid: 20547756
references.citation: Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3073-8
references.pmid: 10737787
references.citation: Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):695-707
references.pmid: 23328451
references.citation: Mol Cell. 2007 Oct 12;28(1):68-78
references.pmid: 17936705
references.citation: Trends Cell Biol. 2012 Nov;22(11):592-601
references.pmid: 22951073
references.citation: Biochem Pharmacol. 2010 Oct 15;80(8):1230-7
references.pmid: 20599775
references.citation: Nucleic Acids Res. 2003 Jan 1;31(1):421-3
references.pmid: 12520039
references.citation: Biochem Soc Trans. 2002 Nov;30(Pt 6):945-52
references.pmid: 12440952
references.citation: Cell Mol Life Sci. 2010 Sep;67(17):2937-55
references.pmid: 20495997
references.citation: Mol Biol Cell. 2011 Mar 15;22(6):858-67
references.pmid: 21233287
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2646-51
references.pmid: 18272483
references.citation: Oncogene. 2015 May 28;34(22):2934-42
references.pmid: 25088200
references.citation: J Biol Chem. 2012 Sep 14;287(38):32277-87
references.pmid: 22829587
references.citation: RNA Biol. 2011 Jul-Aug;8(4):681-91
references.pmid: 21691152
references.citation: Exp Cell Res. 2008 Jul 1;314(11-12):2266-78
references.pmid: 18570922
references.citation: RNA. 2015 Oct;21(10 ):1757-69
references.pmid: 26249002
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1442-7
references.pmid: 18234856
references.citation: Cell Signal. 2014 Feb;26(2):433-43
references.pmid: 24172859
references.citation: Genes Dev. 2005 Feb 1;19(3):351-61
references.pmid: 15687258
references.citation: RNA Biol. 2008 Oct-Dec;5(4):201-7
references.pmid: 18971639
references.citation: Mol Cell Biol. 2006 Mar;26(6):2399-407
references.pmid: 16508014
references.citation: Curr Opin Genet Dev. 2011 Aug;21(4):444-51
references.pmid: 21497082
references.citation: Genes Dev. 2008 Jul 1;22(13):1804-15
references.pmid: 18593881
references.citation: EMBO J. 2004 Jan 28;23(2):406-17
references.pmid: 14726956
references.citation: Pharmacol Res. 2008 Jan;57(1):60-6
references.pmid: 18206386