title: Decreased interhemispheric functional connectivity in insula and angular gyrus/supramarginal gyrus: Significant findings in first-episode, drug-naive somatization disorder.
abstract: Neuroimaging data have demonstrated brain functional alterations in patients with somatization disorder (SD). However, there is little information on interhemispheric resting-state functional connectivity (FC) in SD. In this study, resting-state functional magnetic resonance imaging (fMRI) and voxel-mirrored homotopic connectivity (VMHC) were applied to examine the changes of interhemispheric FC of the whole brain in patients with SD. A total of 25 first-episode, medication-naive SD patients and 28 age-, sex-, education-matched healthy controls (HC) underwent resting-state fMRI, and the data were analyzed by VMHC. Compared with HC, patients had lower VMHC in the angular gyrus/supramarginal gyrus (AG/SG) and insula. The reproducibility of the results was validated using the split-half and leave-one-out validations. No significant correlation was found between the VMHC in AG/SG or insula and clinical variables. Our findings indicate that the interhemispheric FC in the AG/SG and insula is decreased in first-episode, treatment-naive patients with SD, and thus provide new insight for disruption of interhemispheric FC in the pathophysiological mechanism of SD.
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Qinji
authors.initials: Q
authors.lastname: Su
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Yao
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Muliang
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Liling
authors.initials: L
authors.lastname: Long
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Miaoyu
authors.initials: M
authors.lastname: Yu
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, PR China. Electronic address: guowenbin76@163.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D063132:Connectome / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D013001:Somatoform Disorders / Q000503:physiopathology*
keywords: Angular gyrus/supramarginal gyrus; Insula; Somatization disorder; Voxel-mirrored homotopic connectivity