title: A potential anatomic subtype of short bowel syndrome: a matched case-control study.
abstract: BACKGROUND
  Fundamental researches suggest that ileum presents greater adaptive potential than the jejunum. However, few studies estimate the association between ileum and adaptive potential in human. To discover the association, we conducted this matched case-control study.
  
  
  METHODS
  A 1:2 pair-matched, case-control study was conducted from January 1, 2001 to January 1, 2015 in Intestinal Rehabilition and Transplant Center. The case group was ileum predominated (IP) group and the control group was jejunum predominated (JP) group. Demographic data, medical history and progression of each patient were collected.
  
  
  RESULTS
  There were 24 IP cases and 48 JP controls in this study. The cumulative probabilities of parenteral nutrition (PN) weaning in IP group were higher than that in JP group. The Bristol stool scale scores of IP group were lower than that of JP group at third month. The Cox proportional hazards regression model confirmed that IP had a higher odds of PN weaning (OR = 2.69; 95 % CI: 1.27, 5.70, p = 0.01) as compared with JP group. The conditional logistic regression with 1:2 matching also confirmed IP group had a higher odds (OR = 4.84; 95 % CI: 2.02, 11.56, p <0.01).
  
  
  CONCLUSIONS
  Our results indicated that ileum presents greater adaptive potential than the jejunum in nutrition and fluid absorption. And a potential anatomic subtype of short bowel syndrome was proposed. Further research need to be conducted to more fully understand the adaptive potential of ileum besides nutrition and fluid absorption.
authors.affiliation: Department of Gastroenterological Surgery, Hangzhou First People's Hospital, School of Clinical Medicine, Nanjing Medical University, Hangzhou, 310006, China.
authors.forename: Wencheng
authors.initials: W
authors.lastname: Kong
authors.affiliation: Intestinal Rehabilition and Transplant Center, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gastroenterological Surgery, Hangzhou First People's Hospital, School of Clinical Medicine, Nanjing Medical University, Hangzhou, 310006, China.
authors.forename: Rongchao
authors.initials: R
authors.lastname: Ying
authors.affiliation: Intestinal Rehabilition and Transplant Center, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China. liys@medmail.com.cn.|Department of Surgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, China. liys@medmail.com.cn.
authors.forename: Yousheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Gastroenterological Surgery, Hangzhou First People's Hospital, School of Clinical Medicine, Nanjing Medical University, Hangzhou, 310006, China.
authors.forename: Huicheng
authors.initials: H
authors.lastname: Jin
authors.affiliation: Intestinal Rehabilition and Transplant Center, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Mao
authors.affiliation: Intestinal Rehabilition and Transplant Center, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China.
authors.forename: Danhua
authors.initials: D
authors.lastname: Yao
authors.affiliation: Department of Gastroenterological Surgery, Linyi People's Hospital, Shandong, 276000, China.
authors.forename: Mingxiao
authors.initials: M
authors.lastname: Guo
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007082:Ileum / Q000503:physiopathology*; D007583:Jejunum / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012778:Short Bowel Syndrome / Q000145:classification / Q000503:physiopathology* / Q000628:therapy; D014886:Weaning
references.citation: Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G612-25
references.pmid: 11518673
references.citation: Am J Surg. 2014 Jun;207(6):942-8
references.pmid: 24507944
references.citation: Dig Liver Dis. 2004 Jan;36(1):46-55
references.pmid: 14971815
references.citation: Digestion. 1978;18(5-6):329-36
references.pmid: 750260
references.citation: Dig Dis Sci. 1980 Jan;25(1):33-41
references.pmid: 7353449
references.citation: Gut. 1987;28 Suppl:165-8
references.pmid: 3692304
references.citation: Ann Surg. 1995 Sep;222(3):243-54; discussion 254-5
references.pmid: 7677455
references.citation: JPEN J Parenter Enteral Nutr. 1996 Jul-Aug;20(4):275-80
references.pmid: 8865109
references.citation: Scand J Gastroenterol. 1997 Sep;32(9):920-4
references.pmid: 9299672
references.citation: Dig Dis Sci. 1999 Jan;44(1):63-74
references.pmid: 9952225
references.citation: Clin Gastroenterol Hepatol. 2006 Jan;4(1):6-10
references.pmid: 16431298
references.citation: Curr Opin Endocrinol Diabetes Obes. 2007 Feb;14(1):63-7
references.pmid: 17940422
references.citation: Nat Med. 2011 Jun;17(6):684-91
references.pmid: 21602802
references.citation: Curr Probl Surg. 2012 Feb;49(2):52-115
references.pmid: 22244264
references.citation: Gastroenterology. 2012 Dec;143(6):1473-1481.e3
references.pmid: 22982184
references.citation: JPEN J Parenter Enteral Nutr. 2013 Mar;37(2):161-70
references.pmid: 23264168
references.citation: Clin Nutr. 2013 Jun;32(3):368-74
references.pmid: 22992308
references.citation: Bone. 2013 Oct;56(2):337-42
references.pmid: 23851294
references.citation: JPEN J Parenter Enteral Nutr. 2014 May;38(1 Suppl):38S-44S
references.pmid: 24463352
references.citation: JPEN J Parenter Enteral Nutr. 2014 May;38(1 Suppl):14S-22S
references.pmid: 24500909
references.citation: JPEN J Parenter Enteral Nutr. 2014 May;38(1 Suppl):23S-31S
references.pmid: 24586019
references.citation: Gastroenterology. 2003 Apr;124(4):1111-34
references.pmid: 12671904