title: Genetic Discoveries in Atrial Fibrillation and Implications for Clinical Practice.
abstract: Atrial fibrillation (AF) is an arrhythmia with a genetic basis. Over the past decade, rapid advances in genotyping technology have revolutionised research regarding the genetic basis of AF. While AF genetics research was previously largely restricted to familial forms of AF, recent studies have begun to characterise the genetic architecture underlying the form of AF encountered in everyday clinical practice. These discoveries could have a significant impact on the management of AF. However, much work remains before genetic findings can be translated to clinical practice. This review summarises results of studies in AF genetics to date and discusses the potential implications of these findings in clinical practice.
authors.affiliation: Leeds General Infirmary, Leeds, UK.
authors.forename: Saagar
authors.initials: S
authors.lastname: Mahida
keywords: Atrial fibrillation; candidate gene association studies; familial AF; genetics; genome-wide association studies; linkage analysis; risk stratification
references.citation: Front Physiol. 2012 Jan 06;2:120
references.pmid: 22232608
references.citation: Int J Mol Med. 2013 Jan;31(1):43-50
references.pmid: 23175127
references.citation: Am Heart J. 2004 Sep;148(3):545-50
references.pmid: 15389246
references.citation: Eur J Med Genet. 2012 Oct;55(10):520-6
references.pmid: 22750565
references.citation: Can J Cardiol. 2013 Aug;29(8):993-6
references.pmid: 23498838
references.citation: Clin Chim Acta. 2007 Jan;375(1-2):87-91
references.pmid: 17010328
references.citation: Harvey Lect. 2002-2003;98:41-64
references.pmid: 16033157
references.citation: J Am Coll Cardiol. 2012 Aug 7;60(6):539-45
references.pmid: 22726630
references.citation: Nat Rev Genet. 2002 May;3(5):391-7
references.pmid: 11988764
references.citation: Am J Hum Genet. 2004 Nov;75(5):899-905
references.pmid: 15368194
references.citation: J Cell Sci. 2010 Apr 1;123(Pt 7):1141-50
references.pmid: 20215401
references.citation: Cardiovasc Res. 2013 Jun 1;98(3):488-95
references.pmid: 23400760
references.citation: Eur J Med Genet. 2010 Jul-Aug;53(4):201-3
references.pmid: 20363377
references.citation: Nat Clin Pract Cardiovasc Med. 2007 Feb;4(2):110-6
references.pmid: 17245405
references.citation: Cardiology. 2008;111(1):1-7
references.pmid: 18239384
references.citation: Nat Genet. 2010 Mar;42(3):240-4
references.pmid: 20173747
references.citation: J Am Coll Cardiol. 2012 Sep 4;60(10):917-21
references.pmid: 22726627
references.citation: J Am Coll Cardiol. 2007 Feb 6;49(5):578-86
references.pmid: 17276182
references.citation: Arch Intern Med. 2010 Nov 22;170(21):1909-17
references.pmid: 21098350
references.citation: Pharmgenomics Pers Med. 2010;3:87-99
references.pmid: 23226045
references.citation: Circ Cardiovasc Genet. 2011 Apr;4(2):123-33
references.pmid: 21282332
references.citation: Hum Genet. 2009 Dec;126(6):843-9
references.pmid: 19707791
references.citation: J Am Coll Cardiol. 2005 Dec 6;46(11):2100-6
references.pmid: 16325048
references.citation: JAMA. 2004 Jun 16;291(23):2851-5
references.pmid: 15199036
references.citation: Am Heart J. 2002 Sep;144(3):485-90
references.pmid: 12228786
references.citation: Circ Arrhythm Electrophysiol. 2011 Feb;4(1):87-93
references.pmid: 21076161
references.citation: Nature. 2002 Jan 10;415(6868):219-26
references.pmid: 11805846
references.citation: Proc Natl Acad Sci U S A. 2010 May 25;107(21):9753-8
references.pmid: 20457925
references.citation: Nat Genet. 2012 Apr 29;44(6):670-5
references.pmid: 22544366
references.citation: J Hum Genet. 2009 May;54(5):277-83
references.pmid: 19343045
references.citation: Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2714-23
references.pmid: 16055520
references.citation: Heart Rhythm. 2006 Jul;3(7):808-12
references.pmid: 16818212
references.citation: Clin Pharmacol Ther. 2007 Jan;81(1):35-41
references.pmid: 17185997
references.citation: JAMA. 2005 Jan 26;293(4):447-54
references.pmid: 15671429
references.citation: Clinics (Sao Paulo). 2012 Dec;67(12):1393-9
references.pmid: 23295592
references.citation: BMC Med Genet. 2012 Apr 03;13:24
references.pmid: 22471742
references.citation: Eur Heart J. 2006 Jul;27(14):1712-8
references.pmid: 16760206
references.citation: J Am Coll Cardiol. 2008 Oct 14;52(16):1326-34
references.pmid: 18929244
references.citation: Eur J Hum Genet. 2014 Dec;22(12):1357-61
references.pmid: 24667784
references.citation: Am J Cardiol. 2011 Jan;107(1):85-91
references.pmid: 21146692
references.citation: N Engl J Med. 2006 Jan 12;354(2):151-7
references.pmid: 16407510
references.citation: Cardiovasc Res. 2014 Feb 1;101(2):326-34
references.pmid: 24296650
references.citation: Cardiovasc Res. 2014 Feb 1;101(2):317-25
references.pmid: 24282291
references.citation: Int J Mol Med. 2007 Jun;19(6):933-9
references.pmid: 17487426
references.citation: Heart Rhythm. 2008 Mar;5(3):427-35
references.pmid: 18313602
references.citation: Nat Genet. 2009 Aug;41(8):879-81
references.pmid: 19597492
references.citation: Lancet. 2009 Feb 28;373(9665):739-45
references.pmid: 19249635
references.citation: N Engl J Med. 2008 Jul 10;359(2):158-65
references.pmid: 18614783
references.citation: Heart Rhythm. 2008 Jan;5(1):99-105
references.pmid: 18088563
references.citation: Circulation. 2008 Apr 15;117(15):1927-35
references.pmid: 18378609
references.citation: J Am Coll Cardiol. 2014 Apr 1;63(12):1200-10
references.pmid: 24486271
references.citation: Arch Intern Med. 2012 May 14;172(9):742-4
references.pmid: 22782207
references.citation: Circulation. 2004 Apr 6;109(13):1640-6
references.pmid: 15023884
references.citation: Biochem Biophys Res Commun. 2009 Feb 27;380(1):132-7
references.pmid: 19167345
references.citation: Eur Heart J. 2013 Aug;34(29):2243-51
references.pmid: 23444395
references.citation: Int J Cardiol. 2007 Mar 2;116(1):107-12
references.pmid: 16814413
references.citation: Cell Physiol Biochem. 2008;21(1-3):47-54
references.pmid: 18209471
references.citation: Heart Rhythm. 2014 Feb;11(2):246-51
references.pmid: 24144883
references.citation: Circ Cardiovasc Genet. 2011 Jun;4(3):269-79
references.pmid: 21511879
references.citation: J Am Coll Cardiol. 2010 Feb 23;55(8):747-53
references.pmid: 20170812
references.citation: Heart. 2008 Nov;94(11):1394-6
references.pmid: 18931155
references.citation: Eur Heart J. 2006 Mar;27(6):708-12
references.pmid: 16428254
references.citation: N Engl J Med. 2006 Jun 22;354(25):2677-88
references.pmid: 16790700
references.citation: Eur Heart J. 2008 Apr;29(7):907-14
references.pmid: 18222980
references.citation: J Biol Chem. 2013 Jun 14;288(24):17472-80
references.pmid: 23640888
references.citation: J Biol Chem. 2002 Apr 19;277(16):13998-4004
references.pmid: 11842093
references.citation: Nat Genet. 2009 Aug;41(8):876-8
references.pmid: 19597491
references.citation: N Engl J Med. 2010 Jul 8;363(2):166-76
references.pmid: 20647212
references.citation: Nat Biotechnol. 2012 Apr 10;30(4):317-20
references.pmid: 22491277
references.citation: Can J Cardiol. 2013 Jan;29(1):111-6
references.pmid: 23040431
references.citation: PLoS One. 2013 Jul 18;8(7):e68690
references.pmid: 23874724
references.citation: Int J Mol Med. 2011 Dec;28(6):1025-32
references.pmid: 21874226
references.citation: Hum Mol Genet. 2006 Jul 15;15(14):2185-91
references.pmid: 16772329
references.citation: Int J Mol Med. 2010 Oct;26(4):605-10
references.pmid: 20818502
references.citation: J Am Coll Cardiol. 2012 Sep 25;60(13):1173-81
references.pmid: 22818067
references.citation: J Mol Cell Cardiol. 2012 Aug;53(2):187-95
references.pmid: 22659290
references.citation: Eur Heart J. 2013 May;34(20):1517-25
references.pmid: 23264583
references.citation: Circulation. 2004 Dec 21;110(25):3753-9
references.pmid: 15596564
references.citation: Eur Heart J. 2009 Apr;30(7):813-9
references.pmid: 19141561
references.citation: Mol Biol Rep. 2012 Aug;39(8):8127-35
references.pmid: 22552926
references.citation: J Am Coll Cardiol. 2013 Nov 19;62(21):2010-9
references.pmid: 23973696
references.citation: Clin Chim Acta. 2011 Sep 18;412(19-20):1825-30
references.pmid: 21708142
references.citation: Nat Genet. 2011 Jun;43(6):513-8
references.pmid: 21614091
references.citation: Eur Heart J. 2013 Aug;34(29):2227-9
references.pmid: 23585492
references.citation: Cell. 1998 Aug 7;94(3):307-17
references.pmid: 9708733
references.citation: Heart Rhythm. 2013 Jun;10(6):849-55
references.pmid: 23428961
references.citation: Nature. 2009 Oct 8;461(7265):747-53
references.pmid: 19812666
references.citation: Circ Arrhythm Electrophysiol. 2009 Jun;2(3):268-75
references.pmid: 19808477
references.citation: Heart Rhythm. 2009 Aug;6(8):1146-53
references.pmid: 19632626
references.citation: Am J Physiol Cell Physiol. 2012 Aug 1;303(3):C318-27
references.pmid: 22621787
references.citation: Cardiovasc Res. 2005 Dec 1;68(3):433-40
references.pmid: 16109388
references.citation: Int J Mol Med. 2012 Oct;30(4):783-90
references.pmid: 22824924
references.citation: Clin Pharmacol Ther. 2014 Mar;95(3):281-93
references.pmid: 24322971
references.citation: Circ Res. 2005 Mar 18;96(5):e35-47
references.pmid: 15731458
references.citation: Circulation. 2003 Sep 9;108 Suppl 1:II195-9
references.pmid: 12970232
references.citation: Circ Res. 2008 Jun 6;102(11):1433-42
references.pmid: 18451335
references.citation: Pharmacogenet Genomics. 2008 Jun;18(6):525-33
references.pmid: 18496132
references.citation: J Am Coll Cardiol. 2012 Jan 3;59(1):49-56
references.pmid: 22192668
references.citation: Eur Heart J. 2004 May;25(10):879-84
references.pmid: 15140537
references.citation: Heart Rhythm. 2013 Mar;10(3):394-400
references.pmid: 23178686
references.citation: Hum Genet. 2005 Nov;118(2):179-84
references.pmid: 16133178
references.citation: Circulation. 2014 Jan 28;129(4):430-40
references.pmid: 24190961
references.citation: Am J Cardiol. 2005 Aug 1;96(3):405-7
references.pmid: 16054468
references.citation: Nature. 2007 Jul 19;448(7151):353-7
references.pmid: 17603472
references.citation: Int J Cardiol. 2007 Aug 9;120(1):59-65
references.pmid: 17113662
references.citation: Heart. 2004 Dec;90(12):1487-8
references.pmid: 15547041
references.citation: Europace. 2010 Oct;12(10):1421-7
references.pmid: 20650941
references.citation: Cardiovasc Res. 2011 Mar 1;89(4):786-93
references.pmid: 21051419
references.citation: Circ Cardiovasc Genet. 2012 Aug 1;5(4):450-9
references.pmid: 22685113
references.citation: Science. 2003 Jan 10;299(5604):251-4
references.pmid: 12522251
references.citation: BMC Med Genet. 2006 Aug 03;7:70
references.pmid: 16887036
references.citation: Hum Mutat. 2013 Apr;34(4):603-9
references.pmid: 23348765
references.citation: PLoS Genet. 2009 Mar;5(3):e1000433
references.pmid: 19300499
references.citation: Circ Res. 2007 Feb 16;100(3):354-62
references.pmid: 17234970
references.citation: Biochem Biophys Res Commun. 2005 Jul 15;332(4):1012-9
references.pmid: 15922306
references.citation: Circ Res. 2004 Jun 11;94(11):1507-14
references.pmid: 15117820