title: Matrin3: connecting gene expression with the nuclear matrix.
abstract: As indicated by its name, Matrin3 was discovered as a component of the nuclear matrix, an insoluble fibrogranular network that structurally organizes the nucleus. Matrin3 possesses both DNA- and RNA-binding domains and, consistent with this, has been shown to function at a number of stages in the life cycle of messenger RNAs. These numerous activities indicate that Matrin3, and indeed the nuclear matrix, do not just provide a structural framework for nuclear activities but also play direct functional roles in these activities. Here, we review the structure, functions, and molecular interactions of Matrin3 and of Matrin3-related proteins, and the pathologies that can arise upon mutation of Matrin3. WIREs RNA 2016, 7:303-315. doi: 10.1002/wrna.1336 For further resources related to this article, please visit the WIREs website.
authors.affiliation: Department of Biochemistry, University of Cambridge, Cambridge, UK.
authors.forename: Miguel B
authors.initials: MB
authors.lastname: Coelho
authors.affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
authors.forename: Jan
authors.initials: J
authors.lastname: Attig
authors.affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
authors.forename: Jernej
authors.initials: J
authors.lastname: Ule
authors.affiliation: Department of Biochemistry, University of Cambridge, Cambridge, UK.
authors.forename: Christopher W J
authors.identifier: 0000-0002-2753-3398
authors.initials: CW
authors.lastname: Smith
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D034521:Nuclear Matrix-Associated Proteins / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D034521:Nuclear Matrix-Associated Proteins; D016601:RNA-Binding Proteins