title: [Therapeutic effect of acupuncture treatment on ischemic hypoxic neonate rats with cerebral palsy].
abstract: OBJECTIVE
  To explore the mechanisms of acupuncture treatment promoting the motor function recovery of neonate rats with cerebral palsy.
  
  
  METHODS
  The improved hypoxic-ischemic encephalopathy (HIE) means was performed to establish the model of neonate rats with cerebral palsy. All neonate rats were randomly divided into 3 groups: sham group, model group and acupuncture group (n = 20). We observed and scored motor function of rats, measured the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in serum, and also measured the expression of synaptophysin (SYP) and growth associated protein-43 (GAP-43) in the diseased region of cerebral tissue.
  
  
  RESULTS
  The motor function scores (11.3 +/- 0.29) and the serum level of SOD (147.1 +/- 12.7) U/ml in acupuncture treatment group were higher than those of model group ( P < 0.05). The serum level of MDA was lower in acupuncture treatment group than that of model group (P < 0.05). The expression of SYP and GAP-43 in the diseased region of cerebral tissue of acupuncture treatment group were higher than those of model group ( P < 0.05) .
  
  
  CONCLUSIONS
  Acupuncture-therapy could improve the motor function of neonate rats with cerebral palsy by decreasing the content of MDA in serum, increasing the contents of SOD in serum, and prolonging the upregulation of SYP and GAP-43 expressions in hmin tissue.
authors.forename: Su-hui
authors.initials: SH
authors.lastname: Li
authors.forename: Hong-tao
authors.initials: HT
authors.lastname: Sun
authors.forename: Yan-min
authors.initials: YM
authors.lastname: Wang
authors.forename: Zheng-jun
authors.initials: ZJ
authors.lastname: Wei
mesh_terms: D015670:Acupuncture Therapy; D000818:Animals; D000831:Animals, Newborn; D002547:Cerebral Palsy / Q000628:therapy*; D004195:Disease Models, Animal; D019922:GAP-43 Protein / Q000378:metabolism; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy*; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D019922:GAP-43 Protein; D016708:Synaptophysin; D008315:Malondialdehyde; D013482:Superoxide Dismutase