title: Oncocytic carcinoma of the major salivary glands: A population-based study of 278 cases.
abstract: Oncocytic carcinomas of the major salivary glands are extremely rare, with <100 cases reported.
  
  
  
  A retrospective review of the National Cancer Database was performed from 1998 to 2012.
  
  
  
  We found 278 cases of major salivary oncocytic carcinoma. Most patients were men (61.9%), white (84.8%), with parotid disease (88.5%). Median age was 67 years (range, 16-90 years). Regional and distant metastases were found in 36.4% and 4.7% of cases. Overall survival at 5 and 10-years was 64% and 39%, respectively. Distant metastasis (hazard ratio [HR] = 13.87; 95% confidence interval [CI] = 2.98-64.52; p = .0010) and regional metastasis (HR = 3.01; 95% CI = 1.20-7.55; p = .019) are significant negative predictors, whereas positive margins approached significance (HR = 3.01; 95% CI = 1.20-7.55; p = .074).
  
  
  
  Oncocytic carcinoma has a poor long-term prognosis and lymph node metastases are common. Distant and regional metastases are significant predictors of decreased survival. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1981-E1986, 2016.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Kevin Y
authors.initials: KY
authors.lastname: Zhan
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Lentsch
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000453:epidemiology* / Q000473:pathology; D012469:Salivary Glands / Q000473:pathology*; D015996:Survival Rate; D055815:Young Adult
keywords: malignant oncocytoma; malignant oxyphilic adenoma; oncocytic adenocarcinoma; oncocytic carcinoma; oxyphilic adenocarcinoma; parotid tumor; salivary gland tumor; submandibular tumor