title: Lack of evidence of hepatitis in patients with oral lichen planus in China: A case control study.
abstract: BACKGROUND
  China has been one of the countries with high prevalence of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) liver disease. And lichen planus is an extrahepatic manifestation of patients with chronic HCV infection. This case-control study was conducted to investigate the relationship between oral lichen planus (OLP) and HBV/HCV infection in China.
  
  
  METHODS
  A total of 776 patients, including 150 patients with OLP (Group OLP), 429 inpatients from the Trauma Ward of Oral and Maxillofacial Surgery Department (Group A), 110 patients with other oral mucosal diseases, but without a reported association with HCV infection (Group B) and 87 patients with oral lichenoid lesion (Group OLL), were compared with their seroprevalence of anti-HCV antibody (HCVAb), hepatitis B surface antigen (HBsAg) and the parameters of liver functions. Moreover, the clinical characteristics of OLP were also observed, such as gender, age, chief complaint, course of the disease, clinical type, sites involved and so on.
  
  
  RESULTS
  The positive rates of HCVAb and HBsAg in OLP patients were 0.7% and 4%, respectively. Neither HCVAb nor HBsAg was associated with OLP as demonstrated by both the univariate and the multivariate analyses. The clinical features and liver functions of OLP patients with negative or positive HBsAg were nearly the same.
  
  
  CONCLUSIONS
  Our findings verify that there is no association between OLP and hepatitis and there is no need to run a screening test for HCV or HBV in OLP patients in China.
authors.affiliation: Department of Oral Medicine, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, China, HongweiL5362@163.com.
authors.forename: Jiangyuan
authors.initials: J
authors.lastname: Song
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Ji
authors.forename: Sha
authors.initials: S
authors.lastname: Su
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Liu
authors.forename: Si
authors.initials: S
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.forename: Dongdong
authors.initials: D
authors.lastname: Mu
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D005260:Female; D006511:Hepatitis B Antigens / Q000097:blood*; D019694:Hepatitis B, Chronic / Q000150:complications; D018937:Hepatitis C Antibodies / Q000097:blood*; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D017676:Lichen Planus, Oral / Q000097:blood* / Q000821:virology; D008297:Male; D008875:Middle Aged
chemical_list: D006511:Hepatitis B Antigens; D018937:Hepatitis C Antibodies
references.citation: J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:7-10
references.pmid: 23855289
references.citation: J Oral Pathol Med. 2000 Jul;29(6):255-8
references.pmid: 10890555
references.citation: Med Oral Patol Oral Cir Bucal. 2005;10 Suppl 1:E40-4
references.pmid: 15800466
references.citation: Ital Gen Rev Dermatol. 1978 May-Aug;15(2):123-31
references.pmid: 553075
references.citation: Odontology. 2011 Jul;99(2):168-78
references.pmid: 21505737
references.citation: Eur J Gastroenterol Hepatol. 2007 Aug;19(8):647-52
references.pmid: 17625433
references.citation: Leukemia. 1996 Jul;10(7):1209-13
references.pmid: 8684003
references.citation: J Oral Pathol Med. 2003 Oct;32(9):507-12
references.pmid: 12969224
references.citation: Hepatology. 2002 Dec;36(6):1446-52
references.pmid: 12447871
references.citation: Int J Oral Sci. 2010 Jun;2(2):90-7
references.pmid: 20737935
references.citation: Oral Dis. 2004 Sep;10(5):283-6
references.pmid: 15315645
references.citation: Clin Otolaryngol Allied Sci. 2002 Feb;27(1):22-6
references.pmid: 11903367
references.citation: Int J Dermatol. 2002 Apr;41(4):217-9
references.pmid: 12031030
references.citation: J Am Acad Dermatol. 1991 May;24(5 Pt 1):792
references.pmid: 1651354
references.citation: Oral Dis. 2003 Nov;9(6):292-7
references.pmid: 14629329
references.citation: N Y State Dent J. 2008 Jun-Jul;74(4):66-8
references.pmid: 18788185
references.citation: Science. 1989 Apr 21;244(4902):359-62
references.pmid: 2523562
references.citation: Oral Health Dent Manag. 2012 Dec;11(4):199-205
references.pmid: 23208597
references.citation: BMJ. 1990 Jan 27;300(6719):227-30
references.pmid: 2106930
references.citation: J Family Community Med. 1998 Jul;5(2):39-43
references.pmid: 23008588
references.citation: Br J Dermatol. 2004 Dec;151(6):1172-81
references.pmid: 15606512
references.citation: BMC Gastroenterol. 2012;12:31
references.pmid: 22490000
references.citation: J Viral Hepat. 1997 Jan;4(1):9-28
references.pmid: 9031061
references.citation: J Pharm Bioallied Sci. 2012 Aug;4(Suppl 2):S397-405
references.pmid: 23066298
references.citation: J Clin Gastroenterol. 2004 Nov-Dec;38(10 Suppl 3):S158-68
references.pmid: 15602165
references.citation: Med Oral Patol Oral Cir Bucal. 2009 Jul;14(7):E310-4
references.pmid: 19300362
references.citation: J Eur Acad Dermatol Venereol. 2011 Apr;25(4):436-40
references.pmid: 20666875
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Aug;98(2):171-83
references.pmid: 15316544
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Mar;109(3):408-14
references.pmid: 20097108
references.citation: J Viral Hepat. 2004 Sep;11(5):465-70
references.pmid: 15357654