title: A green synthesis in water of novel (1,5,3-dithiazepan-3-yl)alkanoic acids by the multicomponent reaction of amino acids, CH2O, and 1,2-ethanedithiol.
abstract: A library of new (1,5,3-dithiazepan-3-yl)alkanoic acids was prepared by the multicomponent cyclocondensation of amino acids, formaldehyde, and 1,2-ethanedithiol in water at room temperature for 1 to 5 h in high yields. This green procedure offers several advantages such as an operational simplicity, no catalyst, and no production of hazardous materials.
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, Ufa, Russian Federation, 450075. khabibguzel@gmail.com.
authors.forename: Guzel R
authors.initials: GR
authors.lastname: Khabibullina
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, Ufa, Russian Federation, 450075.
authors.forename: Ekaterina S
authors.initials: ES
authors.lastname: Fedotova
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, Ufa, Russian Federation, 450075. vnirara@mail.ru.
authors.forename: Vnira R
authors.initials: VR
authors.lastname: Akhmetova
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, Ufa, Russian Federation, 450075.
authors.forename: Ekaterina S
authors.initials: ES
authors.lastname: Mesheryakova
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, Ufa, Russian Federation, 450075.
authors.forename: Leonard M
authors.initials: LM
authors.lastname: Khalilov
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, Ufa, Russian Federation, 450075.
authors.forename: Askhat G
authors.initials: AG
authors.lastname: Ibragimov
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D005557:Formaldehyde / Q000737:chemistry*; D055772:Green Chemistry Technology; D008623:Mercaptoethanol / Q000031:analogs & derivatives* / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D002264:Carboxylic Acids; D014867:Water; D005557:Formaldehyde; D008623:Mercaptoethanol; C031854:1,2-ethanedithiol
keywords: (1,5,3-Dithiazepan-3-yl)alkanoic acids; Amino acids; Green synthesis; MRCs; Multicomponent reaction; Water
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