title: DNA Methylation and microRNA patterns are in association with the expression of BRCA1 in ovarian cancer.
abstract: Ovarian cancer is the sixth most prevalent cancer in women and is considered the most lethal gynecological malignancy. It can be inherited as a familial disease but also has a strong spontaneous occurrence. Although the disease is associated with genome instability brought on by genetics and environmental factors there is evidence that mutations in the gene encoding for the breast cancer type 1 susceptibility protein (BRCA1) or its down-regulation are involved in its development. Down-regulation of BRCA1 expression by hypermethylation of its promoter may account for some cases of ovarian cancer but this does not explain the cause of the majority of the disease. This review explores the role of BRCA1 promoter hypermethylation and micro-RNAs (miRNA) involved in the regulation of BRCA1 and their role in ovarian cancer development as well as some of the exciting discoveries which could lead to targeting miRNA with a view to restoring BRCA1 expression in diseased tissues.
authors.affiliation: Rafsanjan University of Medical Sciences Dept. of Anatomy, Faculty of Medicine Rafsanjan Iran.
authors.forename: M
authors.initials: M
authors.lastname: Shariati-Kohbanani
authors.affiliation: Rafsanjan University of Medical Sciences Immunology of Infectious Diseases Research Center Rafsanjan Iran.
authors.forename: M
authors.initials: M
authors.lastname: Zare-Bidaki
authors.affiliation: Rafsanjan University of Medical Sciences Dept. of Anatomy, Faculty of Medicine Rafsanjan Iran.
authors.forename: M M
authors.initials: MM
authors.lastname: Taghavi
authors.affiliation: Rafsanjan University of Medical Sciences Dept. of Anatomy, Faculty of Medicine Rafsanjan Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Taghipour
authors.affiliation: Rafsanjan University of Medical Sciences Dept. of Anatomy, Faculty of Medicine Rafsanjan Iran shebani54@yahoo.com.
authors.forename: A
authors.initials: A
authors.lastname: Shabanizadeh
authors.affiliation: Griffith University School of Natural Sciences and Eskitis Institute for Drug Discovery Brisbane Australia.
authors.forename: D
authors.initials: D
authors.lastname: Kennedy
authors.affiliation: Isfahan University of Medical Sciences School of Pharmacy and Pharmacutical Sciences Isfahan Iran.
authors.forename: H
authors.initials: H
authors.lastname: Dahim
authors.affiliation: Kermanshah University of Medical Sciences Fertility and Infertility Research Center Kermanshah Iran.
authors.forename: M R
authors.initials: MR
authors.lastname: Salahshoor
authors.affiliation: Kermanshah University of Medical Sciences Fertility and Infertility Research Center Kermanshah Iran.
authors.forename: C
authors.initials: C
authors.lastname: Jalili
authors.affiliation: Rafsanjan University of Medical Sciences Immunology of Infectious Diseases Research Center Rafsanjan Iran.
authors.forename: M
authors.initials: M
authors.lastname: Kazemi Arababadi
mesh_terms: D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics*; D019175:DNA Methylation / Q000235:genetics*; D015536:Down-Regulation / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D019313:BRCA1 Protein; D035683:MicroRNAs