title: Protective Effects of HDL Against Ischemia/Reperfusion Injury.
abstract: Several lines of evidence suggest that, besides being a strong independent predictor of the occurrence of primary coronary events, a low plasma high density lipoprotein (HDL) cholesterol level is also associated with short- and long-term unfavorable prognosis in patients, who have recovered from a myocardial infarction, suggesting a direct detrimental effect of low HDL on post-ischemic myocardial function. Experiments performed in ex vivo and in vivo models of myocardial ischemia/reperfusion (I/R) injury have clearly shown that HDL are able to preserve cardiac function when given before ischemia or at reperfusion; the protective effects of HDL against I/R injury have been also confirmed in other tissues and organs, as brain and hind limb. HDL were shown to act on coronary endothelial cells, by limiting the increase of endothelium permeability and promoting vasodilation and neoangiogenesis, on white blood cells, by reducing their infiltration into the ischemic tissue and the release of pro-inflammatory and matrix-degrading molecules, and on cardiomyocytes, by preventing the activation of the apoptotic cascade. Synthetic HDL retains the cardioprotective activity of plasma-derived HDL and may become a useful adjunctive therapy to improve clinical outcomes in patients with acute coronary syndromes or undergoing coronary procedures.
authors.affiliation: Centro E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano Milan, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Gomaraschi
authors.affiliation: Centro E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano Milan, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Calabresi
authors.affiliation: Centro E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano Milan, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Franceschini
keywords: HDL cholesterol; acute coronary syndrome; high density lipoproteins; ischemia–reperfusion injury; synthetic HDL
references.citation: Atherosclerosis. 2013 Jun;228(2):472-7
references.pmid: 23618097
references.citation: Circulation. 1998 Aug 18;98(7):699-710
references.pmid: 9715863
references.citation: Eur Heart J. 2005 May;26(9):890-6
references.pmid: 15764620
references.citation: Stroke. 2010 Jul;41(7):1536-42
references.pmid: 20522814
references.citation: J Pharmacol Exp Ther. 2004 Jan;308(1):79-84
references.pmid: 14566009
references.citation: Circulation. 2001 Jan 2;103(1):108-12
references.pmid: 11136694
references.citation: Stroke. 2013 Mar;44(3):699-707
references.pmid: 23422087
references.citation: Circ Res. 2003 Feb 21;92(3):330-7
references.pmid: 12595346
references.citation: Pharmacol Ther. 2006 Sep;111(3):836-54
references.pmid: 16960983
references.citation: Cardiovasc Res. 2014 Jan 1;101(1):145-54
references.pmid: 24130189
references.citation: JAMA. 2007 Apr 18;297(15):1675-82
references.pmid: 17387133
references.citation: Arterioscler Thromb Vasc Biol. 2003 Oct 1;23(10):1724-31
references.pmid: 12969988
references.citation: Cerebrovasc Dis. 2004;17(2-3):204-11
references.pmid: 14707423
references.citation: Curr Opin Lipidol. 2013 Dec;24(6):480-6
references.pmid: 24184938
references.citation: Atherosclerosis. 2008 Apr;197(2):572-8
references.pmid: 17945238
references.citation: Atherosclerosis. 2013 May;228(1):110-6
references.pmid: 23497785
references.citation: J Am Soc Nephrol. 2003 Jul;14(7):1833-43
references.pmid: 12819243
references.citation: J Pharmacol Exp Ther. 2008 Feb;324(2):776-83
references.pmid: 18042829
references.citation: Shock. 2004 Apr;21(4):342-51
references.pmid: 15179135
references.citation: Atherosclerosis. 1999 Sep;146(1):117-24
references.pmid: 10487494
references.citation: Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):813-8
references.pmid: 17272742
references.citation: Curr Opin Lipidol. 2002 Jun;13(3):285-8
references.pmid: 12045398
references.citation: J Nutr. 2014 Jul;144(7):1030-6
references.pmid: 24759932
references.citation: PLoS One. 2015 Mar 17;10(3):e0119664
references.pmid: 25781943
references.citation: Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H558-68
references.pmid: 15764676
references.citation: Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1022-8
references.pmid: 20061542
references.citation: Circ Res. 1999 Mar 5;84(4):392-400
references.pmid: 10066673
references.citation: Stroke. 2003 Apr;34(4):863-8
references.pmid: 12637692
references.citation: J Pharmacol Exp Ther. 2004 Dec;311(3):1023-31
references.pmid: 15375174
references.citation: Arch Intern Med. 2002 May 13;162(9):993-9
references.pmid: 11996608
references.citation: FASEB J. 2014 Jan;28(1):206-17
references.pmid: 24022405
references.citation: J Pathol. 2000 Feb;190(3):255-66
references.pmid: 10685060
references.citation: JAMA. 2003 Nov 5;290(17 ):2292-300
references.pmid: 14600188
references.citation: J Am Coll Cardiol. 2008 Apr 22;51(16):1604-12
references.pmid: 18420105
references.citation: FASEB J. 2001 Sep;15(11):1941-52
references.pmid: 11532974
references.citation: Am J Cardiol. 2009 Apr 1;103(7):902-6
references.pmid: 19327413
references.citation: J Am Coll Cardiol. 2015 Apr 14;65(14):1454-71
references.pmid: 25857912
references.citation: J Lab Clin Med. 1987 Jan;109(1):19-26
references.pmid: 3098880
references.citation: J Cereb Blood Flow Metab. 2013 Apr;33(4):575-82
references.pmid: 23299241
references.citation: Neurobiol Dis. 2004 Jun;16(1):1-13
references.pmid: 15207256
references.citation: Pharmacol Res. 2000 Jun;41(6):597-603
references.pmid: 10816328
references.citation: N Engl J Med. 2007 Sep 27;357(13):1301-10
references.pmid: 17898099
references.citation: PLoS One. 2013 Oct 14;8(10):e77211
references.pmid: 24155931
references.citation: Am J Cardiol. 1998 Mar 1;81(5):531-7
references.pmid: 9514445
references.citation: Am J Physiol. 1998 Mar;274(3 Pt 2):R577-95
references.pmid: 9530222
references.citation: Circulation. 2006 Sep 26;114(13):1403-9
references.pmid: 16982942