title: Naproxen conjugated mPEG-PCL micelles for dual triggered drug delivery.
abstract: A conjugate of the NSAIDs drug, naproxen, with diblock methoxy poly(ethylene glycol)-poly(ε-caprolactone) (mPEG-PCL) copolymer was synthesized by the reaction of copolymer with naproxen in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine. The naproxen conjugated copolymers were characterized with different techniques including (1)HNMR, FTIR, and DSC. The naproxen conjugated mPEG-PCL copolymers were self-assembled into micelles in aqueous solution. The TEM analysis revealed that the micelles had the average size of about 80 nm. The release behavior of conjugated copolymer was investigated in two different media with the pH values of 7.4 and 5.2. In vitro release study showed that the drug release rate was dependant on pH as it was higher at lower pH compared to neutral pH. Another feature of the conjugated micelles was a more sustained release profile compared to the conjugated copolymer. The kinetic of the drug release from naproxen conjugated micelles under different values of pH was also investigated by different kinetic models such as first-order, Makoid-Banakar, Weibull, Logistic, and Gompertz.
authors.affiliation: Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Karami
authors.affiliation: Department of Pharmaceutical biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Sadighian
authors.affiliation: Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran; Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. Electronic address: rostamizadeh@zums.ac.ir.
authors.forename: Kobra
authors.initials: K
authors.lastname: Rostamizadeh
authors.affiliation: Department of Toxicology & Pharmacology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Maliheh
authors.initials: M
authors.lastname: Parsa
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Rezaee
mesh_terms: D002460:Cell Line; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008823:Micelles; D009288:Naproxen / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011091:Polyesters / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D008823:Micelles; D011091:Polyesters; C439611:methoxy poly(ethylene glycol-co-epsilon-caprolactone); D011092:Polyethylene Glycols; D009288:Naproxen
keywords: Conjugation; Methoxy poly(ethylene glycol)–poly(ε-caprolactone) copolymers; Micelle; Naproxen; Triggered drug delivery