title: First experience using cultured epidermal autografts in Taiwan for burn victims of the Formosa Fun Coast Water Park explosion, as part of Japanese medical assistance.
abstract: On June 27, 2015, a flammable starch-based powder exploded at Formosa Fun Coast in Taipei, Taiwan, injuring 499 people, and more than 200 people were in critical condition with severe burns. Although a cultured epidermal autograft (CEA) was not approved or used in clinical practice, the Taiwan Food and Drug Administration requested a Japanese CEA manufacturer to donate CEA for the burn victims as part of international medical assistance. The authors cooperated in this project and participated in the patient selection, wound bed management for CEA, and technical assistance for CEA use. Here, we provide an overview of the project. Nine patients were enrolled, and two patients were excluded from the skin biopsy; seven skin biopsies were collected approximately 1 month after the disaster. The average TBSA% burned was 81.0%, and the mean age was 20.1 years. CEA was grafted in five patients; wound closure had been obtained in one patient, and one patient was severely ill at the time of grafting. The CEA was combined with a wide split auto mesh graft or patch graft. The mean re-epithelization rate at 4 weeks after the grafting was 84.2% by patient, and all of the patients survived. Although this project had many obstacles to overcome, CEA grafting was successful and contributed to wound closure and survival.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Tokyo Medical University, 6-7-1 Nishishinjyuku Shinjyuku-ku Tokyo 160-0023, Japan. Electronic address: hmatsu-tki@umin.ac.jp.
authors.forename: Hajime
authors.initials: H
authors.lastname: Matsumura
authors.affiliation: Critical Care and Emergency Center, Yokohama City University Medical Center, 4-57 Urafune, Minami-ku, Yokohama 232-0024, Japan. Electronic address: nharuru@yokohama-cu.ac.jp.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Harunari
authors.affiliation: Department of Emergency Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. Electronic address: ikeda@med.teikyo-u.ac.jp.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ikeda
mesh_terms: D000293:Adolescent; D000328:Adult; D001830:Body Surface Area; D002056:Burns / Q000601:surgery*; D002478:Cells, Cultured / Q000637:transplantation*; D004817:Epidermis / Q000637:transplantation*; D005107:Explosions; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D016038:Skin Transplantation / Q000379:methods*; D013624:Taiwan; D046509:Tissue Culture Techniques / Q000379:methods*; D014182:Transplantation, Autologous / Q000379:methods; D014945:Wound Healing; D055815:Young Adult
keywords: Burn; Cultured epidermal autograft; Grafting