title: The association between metabolic complications and arterial hypertension in obese adolescents.
abstract: OBJECTIVE
  There is increasing evidence for the contribution of obesity and its metabolic sequels in the development of arterial hypertension (AH).
  
  
  METHODS
  The casual blood pressure (CBP), 24hABPM, ambulatory arterial stiffness index (AASI) and symmetric (sAASI) ambulatory arterial stiffness index (both derived from a 24 h ABPM) and selected laboratory tests were performed in 130 obese (mean BMI SDS 4.2) adolescents at the mean age of 13.7 years.
  
  
  RESULTS
  AH was diagnosed in 36.2%, and in 33.8% patients on the basis of CBP and 24hABPM respectively. There were significant correlations between: CBPSBP insulin level (fasting r=0.19, p=0.03 and post glucose load r=0.18, p=0.04), HOMA-IR (r=0.18, p=0.04), and uric acid (UA) level (r=0.35, p<0.001); CBPDBP and UA level (r=0.23, p=0.01). There were significant correlations between 24hABPM parameters and cortisol secretion: dSBP and urinary free cortisol (r=0.3, p=0.03), nDBP and nMAP and cortisol rhythm (r=0.21, p=0.03). There a correlation between sAASI and creatinine level (r=0.29, p=0.002) and negative correlation between AASI and eGFR (r=-0.23, p=0.009).
  
  
  CONCLUSIONS
  The increase of the CBP parameters is associated with insulin resistance and hyperuricemia, while the increase of ABPM results is proportional to the cortisol secretion in obese adolescents.
authors.affiliation: Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, PAIP, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wojcik
authors.affiliation: Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, PAIP, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Malek
authors.affiliation: Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, PAIP, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Janus
authors.affiliation: Department of Statistics, Cracow University of Economics, Krakow, Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Fijorek