title: Resistance and Susceptibility to Malarial Infection: A Host Defense Strategy against Malaria.
abstract: BACKGROUND
  In an effort to understand what limits the virulence of malaria parasites in relation to the host genetic and immunogenic background, we investigated the possibility that the parasite and host genotype crossover interactions constrain virulence.
  
  
  METHODS
  Two groups of mice from different genotypes were used (C57BL/6 (B6) and DBA/2 mice). The mice were infected with a virulent parasite line Plasmodium yoelii 17XL (P. yoelii 17XL). Parasitemia, hematocrit value and lymphocytes yielded by livers and spleens were evaluated. Fluorescence Activated Cell Sorting (FACS) analysis illustrated phenotypic characterization of lymphocytes.
  
  
  RESULTS
  Infection with P. yoelii 17XL did not result in the death of DBA/2 mice. In contrast, B6 mice developed significantly high parasitemia and succumbed to death. Using (FACS) analysis, DBA/2 mice were found to experience a marked expansion of interleukin (IL)-2Rβ(+) CD3(int) cells and γδ T cells in the liver, especially in the recovery phase. The expansion of unconventional T cells (i.e. B220(+) T cells) was also marked in DBA/2 mice.
  
  
  CONCLUSIONS
  The outcome of murine malaria infections depends on the dynamic interplay between the immune-mediator and the genotype of the host.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Assiut University, Assiut, Egypt.
authors.forename: Hanaa
authors.initials: H
authors.lastname: Bakir
authors.affiliation: Department of Parasitology, Faculty of Medicine, Assiut University, Assiut, Egypt.
authors.forename: Doaa
authors.initials: D
authors.lastname: Yones
authors.affiliation: Department of Parasitology, Faculty of Medicine, Assiut University, Assiut, Egypt.
authors.forename: Lamia
authors.initials: L
authors.lastname: Galal
authors.affiliation: Department of Parasitology, Faculty of Medicine, Assiut University, Assiut, Egypt.
authors.forename: Enas
authors.initials: E
authors.lastname: Huseein
keywords: DBA/2 mice; Immune cells; Malaria
references.citation: Infect Immun. 1985 Feb;47(2):452-6
references.pmid: 3967923
references.citation: J Immunol. 1988 Jul 1;141(1):241-8
references.pmid: 3379305
references.citation: J Immunol. 1995 Apr 15;154(8):3985-90
references.pmid: 7706737
references.citation: Parasitol Int. 2010 Sep;59(3):400-6
references.pmid: 20609420
references.citation: Nat Rev Immunol. 2008 Nov;8(11):889-95
references.pmid: 18927577
references.citation: Br J Haematol. 1989 May;72(1):91-9
references.pmid: 2660903
references.citation: Parasitology. 1980 Aug;81(1):211-9
references.pmid: 7422362
references.citation: Science. 2007 Nov 2;318(5851):812-4
references.pmid: 17975068
references.citation: Cell Immunol. 2002 Mar-Apr;216(1-2):43-9
references.pmid: 12381349
references.citation: Eur J Immunol. 2002 Sep;32(9):2521-31
references.pmid: 12207336
references.citation: J Immunol. 1989 Jul 1;143(1):103-12
references.pmid: 2525144
references.citation: J Infect Dis. 1990 Jul;162(1):283-5
references.pmid: 2192010
references.citation: Exp Parasitol. 2005 Aug;110(4):394-405
references.pmid: 15953500
references.citation: PLoS Pathog. 2010 May 20;6(5):e1000916
references.pmid: 20502682
references.citation: J Immunol. 1986 Jun 1;136(11):4075-84
references.pmid: 3009614
references.citation: Parasitol Int. 2013 Feb;62(1):24-31
references.pmid: 22971347
references.citation: J Immunol. 2002 Jul 1;169(1):301-6
references.pmid: 12077258
references.citation: Genes Immun. 2002 Jun;3(4):177-86
references.pmid: 12058252
references.citation: Nat Med. 2011 Jan;17(1):49-51
references.pmid: 21217684
references.citation: J Immunol. 1994 Aug 1;153(3):1187-94
references.pmid: 8027548
references.citation: Infect Immun. 2002 Aug;70(8):4750-3
references.pmid: 12117997
references.citation: Microb Pathog. 2003 Feb;34(2):103-13
references.pmid: 12623278
references.citation: Nature. 1988 Jun 30;333(6176):804-6
references.pmid: 2968519
references.citation: Infect Immun. 2010 Oct;78(10):4331-40
references.pmid: 20660608
references.citation: Cell Immunol. 2001 Jan 10;207(1):28-35
references.pmid: 11161450
references.citation: Cell Immunol. 2001 Aug 1;211(2):96-104
references.pmid: 11591113
references.citation: Infect Immun. 1982 Oct;38(1):80-8
references.pmid: 7141699
references.citation: Curr Hematol Rep. 2004 Mar;3(2):97-106
references.pmid: 14965485
references.citation: Mediators Inflamm. 2014;2014:872464
references.pmid: 25276057
references.citation: Biomed Res. 2011 Jun;32(3):203-8
references.pmid: 21673450
references.citation: Eur J Immunol. 1996 Jul;26(7):1409-16
references.pmid: 8766540
references.citation: J Immunol. 2014 Apr 15;192(8):3686-96
references.pmid: 24634491
references.citation: Clin Exp Immunol. 2000 Aug;121(2):384-90
references.pmid: 10931157
references.citation: Immunol Lett. 1990 Aug;25(1-3):139-41
references.pmid: 2149360
references.citation: PLoS One. 2014 Jan 23;9(1):e85664
references.pmid: 24465641
references.citation: Parasitol Int. 2003 Dec;52(4):259-68
references.pmid: 14665382
references.citation: Immunology. 2006 Jan;117(1):127-35
references.pmid: 16423048
references.citation: J Exp Med. 1996 Aug 1;184(2):687-93
references.pmid: 8760822
references.citation: Clin Exp Immunol. 1997 Jun;108(3):471-6
references.pmid: 9182894
references.citation: Nature. 1995 Jan 19;373(6511):255-7
references.pmid: 7816142
references.citation: Immunol Today. 1992 Aug;13(8):298-300
references.pmid: 1387316
references.citation: Am J Pathol. 2001 Jan;158(1):163-72
references.pmid: 11141489
references.citation: J Immunol. 1995 Sep 15;155(6):2972-83
references.pmid: 7673715
references.citation: J Egypt Soc Parasitol. 2009 Aug;39(2):585-93
references.pmid: 19795764