title: Diverse proportion in composite pheochromocytoma-ganglioneuroma may induce varied clinical symptom: comparison of two cases.
abstract: Composite pheochromocytoma-ganglioneuroma is extremely rare. We described two cases of composite pheochromocytomas in the adrenal medullar. Case 1 was a 70-year-old male presenting with lower abdominal pain and normal blood electrolytes. Case 2 was a 48-year-old female with palpitation and back tenderness. Biochemical investigations showed hypocalcium, hypokalemia and high level of vma. The histological images and the immunohistochemical staining demonstrated the two cases composed of pheochromocytoma and ganglioneuromoma components. Ganglioneuroma component in case 2 accounted for more proportion than that in case 1. We speculated that the varied clinical symptoms were related with the diverse proportions in composite pheochromocytome-ganglioneuroma.
authors.affiliation: Department of Pathology, School of Medicine, Second Affiliated Hospital of Zhejiang University Hangzhou, PR China.
authors.forename: Bu-Yi
authors.initials: BY
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, School of Medicine, Second Affiliated Hospital of Zhejiang University Hangzhou, PR China.
authors.forename: Mingfei
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Pathology, School of Medicine, Second Affiliated Hospital of Zhejiang University Hangzhou, PR China.
authors.forename: Baizhou
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, School of Medicine, Second Affiliated Hospital of Zhejiang University Hangzhou, PR China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Zhang
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D000313:Adrenal Medulla / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000315:Adrenalectomy; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D005729:Ganglioneuroma / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology; D007008:Hypokalemia / Q000209:etiology; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed; D010673:Pheochromocytoma / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
keywords: Composite pheochromocytoma; clinical symptom; ganglioneuroma; pheochromocytoma
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