title: Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015.
abstract: In early 2015, an outbreak of Zika virus, a flavivirus transmitted by Aedes mosquitoes, was identified in northeast Brazil, an area where dengue virus was also circulating. By September, reports of an increase in the number of infants born with microcephaly in Zika virus-affected areas began to emerge, and Zika virus RNA was identified in the amniotic fluid of two women whose fetuses had been found to have microcephaly by prenatal ultrasound. The Brazil Ministry of Health (MoH) established a task force to investigate the possible association of microcephaly with Zika virus infection during pregnancy and a registry for incident microcephaly cases (head circumference ≥2 standard deviations [SD] below the mean for sex and gestational age at birth) and pregnancy outcomes among women suspected to have had Zika virus infection during pregnancy. Among a cohort of 35 infants with microcephaly born during August-October 2015 in eight of Brazil's 26 states and reported to the registry, the mothers of all 35 had lived in or visited Zika virus-affected areas during pregnancy, 25 (71%) infants had severe microcephaly (head circumference >3 SD below the mean for sex and gestational age), 17 (49%) had at least one neurologic abnormality, and among 27 infants who had neuroimaging studies, all had abnormalities. Tests for other congenital infections were negative. All infants had a lumbar puncture as part of the evaluation and cerebrospinal fluid (CSF) samples were sent to a reference laboratory in Brazil for Zika virus testing; results are not yet available. Further studies are needed to confirm the association of microcephaly with Zika virus infection during pregnancy and to understand any other adverse pregnancy outcomes associated with Zika virus infection. Pregnant women in Zika virus-affected areas should protect themselves from mosquito bites by using air conditioning, screens, or nets when indoors, wearing long sleeves and pants, using permethrin-treated clothing and gear, and using insect repellents when outdoors. Pregnant and lactating women can use all U.S. Environmental Protection Agency (EPA)-registered insect repellents according to the product label.
authors.forename: Lavinia
authors.initials: L
authors.lastname: Schuler-Faccini
authors.forename: Erlane M
authors.initials: EM
authors.lastname: Ribeiro
authors.forename: Ian M L
authors.initials: IM
authors.lastname: Feitosa
authors.forename: Dafne D G
authors.initials: DD
authors.lastname: Horovitz
authors.forename: Denise P
authors.initials: DP
authors.lastname: Cavalcanti
authors.forename: André
authors.initials: A
authors.lastname: Pessoa
authors.forename: Maria Juliana R
authors.initials: MJ
authors.lastname: Doriqui
authors.forename: Joao Ivanildo
authors.initials: JI
authors.lastname: Neri
authors.forename: Joao Monteiro de Pina
authors.initials: JM
authors.lastname: Neto
authors.forename: Hector Y C
authors.initials: HY
authors.lastname: Wanderley
authors.forename: Mirlene
authors.initials: M
authors.lastname: Cernach
authors.forename: Antonette S
authors.initials: AS
authors.lastname: El-Husny
authors.forename: Marcos V S
authors.initials: MV
authors.lastname: Pone
authors.forename: Cassio L C
authors.initials: CL
authors.lastname: Serao
authors.forename: Maria Teresa V
authors.initials: MT
authors.lastname: Sanseverino
mesh_terms: D001938:Brazil / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008831:Microcephaly / Q000453:epidemiology* / Q000821:virology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D000071243:Zika Virus Infection / Q000453:epidemiology*