title: Differentiation of cutaneous melanoma from surrounding skin using laser-induced breakdown spectroscopy.
abstract: Laser-induced breakdown spectroscopy (LIBS) has the potential to be used as a surgical tool for simultaneous tissue ablation and elemental analysis of the ablated tissue. LIBS may be used to distinguish melanoma lesions from the surrounding dermis based on the quantitative difference of elements within melanoma lesions. Here, we measured the elements in homogenized pellets and real tissues from excised skin samples of melanoma-implanted mice. In addition, statistical analysis of LIBS spectra using principal component analysis and linear discriminant analysis was performed. Our results showed that this method had high detection sensitivity, highlighting the potential of this tool in clinical applications.
authors.affiliation: Department of Medical System Engineering, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea; Co-first authors with equal contribution.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Han
authors.affiliation: Department of Medical System Engineering, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea; Co-first authors with equal contribution.
authors.forename: Youngmin
authors.initials: Y
authors.lastname: Moon
authors.affiliation: Department of Medical System Engineering, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea.
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea.
authors.forename: Sujeong
authors.initials: S
authors.lastname: Choi
authors.affiliation: Department of Medical System Engineering, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea; School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea; Co-corresponding authors: yongchul@gist.ac.kr.
authors.forename: Yong-Chul
authors.initials: YC
authors.lastname: Kim
authors.affiliation: School of Mechatronics, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea.
authors.forename: Sungho
authors.initials: S
authors.lastname: Jeong
keywords: (120.3890) Medical optics instrumentation; (170.1020) Ablation of tissue; (170.1870) Dermatology; (300.6365) Spectroscopy, laser induced breakdown
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