title: The Zebrafish as a Tool to Cancer Drug Discovery.
abstract: The ability of zebrafish to faithfully recapitulate a variety of human cancers provides a uniquein vivosystem for drug identification and validation. Zebrafish models of human cancer generated through methodologies such as transgenesis, gene inactivation, transplantation, and carcinogenic induction have proven similar to their human counterparts both molecularly and pathologically. Suppression of cancer-relevant phenotypes provides opportunities to both identify and evaluate efficacious compounds using embryonic and adult zebrafish. After relevant compounds are selected, preclinical evaluation in mammalian models can occur, delivering lead compounds to human trials swiftly and rapidly. The advantages ofin vivoimaging, large progeny, and rapid development that the zebrafish provides make it an attractive model to promote novel cancer drug discovery and reduce the hurdles and cost of clinical trials. This review explores the current methodologies to model human cancers in zebrafish, and how these cancer models have aided in formation of novel therapeutic hypotheses.
authors.affiliation: Departments of Pharmacology and Medicine, Cancer Research Center, Section of Hematology and Medical Oncology, Boston University School of Medicine, Boston, MA, USA.
authors.forename: L N
authors.initials: LN
authors.lastname: Huiting
authors.affiliation: Departments of Pharmacology and Medicine, Cancer Research Center, Section of Hematology and Medical Oncology, Boston University School of Medicine, Boston, MA, USA.
authors.forename: Fjf
authors.initials: F
authors.lastname: Laroche
authors.affiliation: Departments of Pharmacology and Medicine, Cancer Research Center, Section of Hematology and Medical Oncology, Boston University School of Medicine, Boston, MA, USA.
authors.forename: H
authors.initials: H
authors.lastname: Feng
keywords: Cancer; Drug discovery; Efficacy; Small molecule screens; Toxicity; Zebrafish
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