title: Histone modifications in DNA damage response.
abstract: DNA damage is a relatively common event in eukaryotic cell and may lead to genetic mutation and even cancer. DNA damage induces cellular responses that enable the cell either to repair the damaged DNA or cope with the damage in an appropriate way. Histone proteins are also the fundamental building blocks of eukaryotic chromatin besides DNA, and many types of post-translational modifications often occur on tails of histones. Although the function of these modifications has remained elusive, there is ever-growing studies suggest that histone modifications play vital roles in several chromatin-based processes, such as DNA damage response. In this review, we will discuss the main histone modifications, and their functions in DNA damage response.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, 100191, China.|Department of Clinical Laboratory, Peking University People's Hospital, Beijing, 100044, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Cao
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, 100191, China.
authors.forename: Changchun
authors.initials: C
authors.lastname: Shen
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, 100191, China. zhuweiguo@bjmu.edu.cn.|Peking University-Tsinghua University Joint Center for Life Sciences, Beijing, 100084, China. zhuweiguo@bjmu.edu.cn.|Shenzhen University School of Medicine, Shenzhen, 518060, China. zhuweiguo@bjmu.edu.cn.
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004249:DNA Damage / Q000502:physiology*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational
chemical_list: D002843:Chromatin; D006657:Histones
keywords: DNA damage response; DNA repair; chromatin; histone modifications