title: The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning.
abstract: This study tested whether maternal responsiveness may buffer the child to the effects of maternal depressive symptoms on DNA methylation of NR3C1, 11β-HSD2, and neuroendocrine functioning. DNA was derived from buccal epithelial cells and prestress cortisol was obtained from the saliva of 128 infants. Mothers with depressive symptoms who were more responsive and who engaged in more appropriate touch during face-to-face play had infants with less DNA methylation of NR3C1 and 11β-HSD2 compared to mothers with depressive symptoms who were also insensitive. The combination of exposure to maternal depressive symptoms and maternal sensitivity was related to the highest prestress cortisol levels, whereas exposure to maternal depressive symptoms and maternal insensitivity was related to the lowest prestress cortisol levels.
authors.affiliation: The University of Utah.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Conradt
authors.affiliation: The Brown Center for the Study of Children at Risk.
authors.forename: Katheleen
authors.initials: K
authors.lastname: Hawes
authors.affiliation: Geisel School of Medicine at Dartmouth.
authors.forename: Dylan
authors.initials: D
authors.lastname: Guerin
authors.affiliation: Geisel School of Medicine at Dartmouth.
authors.forename: David A
authors.initials: DA
authors.lastname: Armstrong
authors.affiliation: Geisel School of Medicine at Dartmouth.
authors.forename: Carmen J
authors.initials: CJ
authors.lastname: Marsit
authors.affiliation: University of Massachusetts.
authors.forename: Edward
authors.initials: E
authors.lastname: Tronick
authors.affiliation: The Brown Center for the Study of Children at Risk.|Warren Alpert Medical School of Brown University.
authors.forename: Barry M
authors.initials: BM
authors.lastname: Lester
mesh_terms: D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D019175:DNA Methylation; D003863:Depression / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007223:Infant; D008297:Male; D008425:Maternal Behavior / Q000502:physiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D055815:Young Adult
chemical_list: C497713:NR3C1 protein, human; D011965:Receptors, Glucocorticoid; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2; C468387:HSD11B2 protein, human; D006854:Hydrocortisone
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