title: Signaling lansdscape of prostate cancer.
abstract: Research over the decades has gradually and sequentially shown that both intratumor heterogeneity and multifocality make prostate cancer difficult to target. Different challenges associated with generation of risk-stratification tools that correlate genomic landscape with clinical outcomes severely influence clinical efficacy of therapeutic strategies. Androgen receptor mediated signaling has gained great appreciation and rewiring of AR induced signaling cascade in absence of androgen, structural variants of AR have provided near complete resolution of genomic landscape and underlying mechanisms of prostate cancer. In this review we have attempted to provide an overview of most recent advancements in our knowledge related to different signaling cascades including TGF, SHH, Notch, JAK-STAT in prostate cancer progression and development.
authors.affiliation: Sichuan Medical University Department of Pharmacy Luzhou China.
authors.forename: X
authors.initials: X
authors.lastname: Lin
authors.affiliation: Faculty of Biological Sciences, QAU Department of Microbiology Islamabad Pakistan.
authors.forename: A
authors.initials: A
authors.lastname: Aslam
authors.affiliation: Yeditepe University Medical School Istanbul Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Attar
authors.affiliation: Istanbul University Department of Molecular Medicine, Institute of Experimental Medicine Istanbul Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Yaylim
authors.affiliation: GCU Department of Chemistry Lahore Pakistan.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Qureshi
authors.affiliation: The Superior College, Lahore Lahore Pakistan.
authors.forename: S
authors.initials: S
authors.lastname: Hasnain
authors.affiliation: Bahauddin Zakariya University Institute of Molecular Biology and Biotechnology Multan Pakistan.
authors.forename: M I
authors.initials: MI
authors.lastname: Qadir
authors.affiliation: RLMC Laboratory For Translational Oncology and Personalized Medicine Lahore Pakistan ammadahmad638@yahoo.com.
authors.forename: A A
authors.initials: AA
authors.lastname: Farooqi
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology*; D011944:Receptors, Androgen / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D011944:Receptors, Androgen