title: Carbamazepine-induced hypertension: A rare case.
abstract: A 74-year-old female with trigeminal neuralgia developed hypertension after the initiation of carbamazepine therapy. The time sequence of start of the suspected drug and onset of hypertension are consistent with the diagnosis. The hypertension did not resolve with antihypertensive therapy or dose reduction of carbamazepine. Patient recovered after the carbamazepine therapy was discontinued. The positive rechallenge and positive dechallenge showed association of carbamazepine therapy with hypertension as its adverse effect. This is a rare case that we report of carbamazepine-induced hypertension and this report may act as alerting mechanism to the health care professionals especially neurologists.
authors.affiliation: Department of Pharmacology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India.
authors.forename: Preeti
authors.initials: P
authors.lastname: Kharb
authors.affiliation: Department of Pharmacology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India.
authors.forename: Niti
authors.initials: N
authors.lastname: Mittal
authors.affiliation: Department of Pharmacology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India.
authors.forename: Mahesh C
authors.initials: MC
authors.lastname: Gupta
keywords: Carbamazepine; hypertension; trigeminal neuralgia
references.citation: Neuroepidemiology. 1991;10(5-6):276-81
references.pmid: 1798430
references.citation: Clin Neuropharmacol. 2003 Jul-Aug;26(4):174-6
references.pmid: 12897634
references.citation: Riv Neurol. 1987 Nov-Dec;57(6):333-5
references.pmid: 3452233
references.citation: Neurology. 2002 Jul 23;59(2):275-6
references.pmid: 12136070
references.citation: Am J Hosp Pharm. 1992 Sep;49(9):2229-32
references.pmid: 1524068
references.citation: Rev Med Suisse. 2005 Nov 2;1(39):2522, 2525-6
references.pmid: 16323733
references.citation: Clin Pharmacol Ther. 1981 Aug;30(2):239-45
references.pmid: 7249508
references.citation: Rinsho Shinkeigaku. 2009 Apr;49(4):191-3
references.pmid: 19462818
references.citation: Rev Med Chil. 2001 Nov;129(11):1325-7
references.pmid: 11836887