title: MicroRNAs Expressed during Viral Infection: Biomarker Potential and Therapeutic Considerations.
abstract: MicroRNAs (miRNAs) are short sequences of noncoding single-stranded RNAs that exhibit inhibitory effects on complementary target mRNAs. Recently, it has been discovered that certain viruses express their own miRNAs, while other viruses activate the transcription of cellular miRNAs for their own benefit. This review summarizes the viral and/or cellular miRNAs that are transcribed during infection, with a focus on the biomarker and therapeutic potential of miRNAs (or their antagomirs). Several human viruses of clinical importance are discussed, namely, herpesviruses, polyomaviruses, hepatitis B virus, hepatitis C virus, human papillomavirus, and human immunodeficiency virus.
authors.affiliation: Department of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Louten
authors.affiliation: Department of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Beach
authors.affiliation: Department of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Palermino
authors.affiliation: Department of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Weeks
authors.affiliation: Department of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA, USA.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Holenstein
keywords: biomarker; hepatitis; herpesvirus; microRNA; virus
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