title: LOng-term follow-up after liVE kidney donation (LOVE) study: a longitudinal comparison study protocol.
abstract: BACKGROUND
  The benefits of live donor kidney transplantation must be balanced against the potential harm to the donor. Well-designed prospective studies are needed to study the long-term consequences of kidney donation.
  
  
  METHODS
  The "LOng-term follow-up after liVE kidney donation" (LOVE) study is a single center longitudinal cohort study on long-term consequences after living kidney donation. We will study individuals who have donated a kidney from 1981 through 2010 in the Erasmus University Medical Center in Rotterdam, The Netherlands. In this time period, 1092 individuals donated a kidney and contact information is available for all individuals. Each participating donor will be matched (1:4) to non-donors derived from the population-based cohort studies of the Rotterdam Study and the Study of Health in Pomerania. Matching will be based on baseline age, gender, BMI, ethnicity, kidney function, blood pressure, pre-existing co-morbidity, smoking, the use of alcohol and highest education degree. Follow-up data is collected on kidney function, kidney-related comorbidity, mortality, quality of life and psychological outcomes in all participants.
  
  
  CONCLUSIONS
  This study will provide evidence on the long-term consequences of live kidney donation for the donor compared to matched non-donors and evaluate the current donor eligibility criteria.
  
  
  BACKGROUND
  Dutch Trial Register NTR3795 .
authors.affiliation: Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. s.janki.1@erasmusmc.nl.
authors.forename: Shiromani
authors.initials: S
authors.lastname: Janki
authors.affiliation: Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. k.klop@erasmusmc.nl.
authors.forename: Karel W J
authors.initials: KW
authors.lastname: Klop
authors.affiliation: Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. h.kimenai@erasmusmc.nl.
authors.forename: Hendrikus J A N
authors.initials: HJ
authors.lastname: Kimenai
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. j.dewetering.1@erasmusmc.nl.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: van de Wetering
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. w.weimar@erasmusmc.nl.
authors.forename: Willem
authors.initials: W
authors.lastname: Weimar
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. e.massey@erasmusmc.nl.
authors.forename: Emma K
authors.initials: EK
authors.lastname: Massey
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. a.dehghan@erasmusmc.nl.
authors.forename: Abbas
authors.initials: A
authors.lastname: Dehghan
authors.affiliation: Department of Biostatistics, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. d.rizopoulos@erasmusmc.nl.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Rizopoulos
authors.affiliation: Ernst Moritz Arndt University Greifswald, Institute for Community Medicine, Walther-Rathenau-Straße 48, D-17475, Greifswald, Germany. voelzke@uni-greifswald.de.
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. a.hofman@erasmusmc.nl.|Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. a.hofman@erasmusmc.nl.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. j.ijzermans@erasmusmc.nl.
authors.forename: Jan N M
authors.initials: JN
authors.lastname: Ijzermans
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000523:psychology*; D019520:Living Donors / Q000523:psychology / Q000706:statistics & numerical data*; D008137:Longitudinal Studies; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011788:Quality of Life; D012107:Research Design; D013997:Time Factors; D055815:Young Adult
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