title: Changes of HFRS Incidence Caused by Vaccine Intervention in Yichun City, China, 2005-2013.
abstract: BACKGROUND
  Since 2009, the Hemorrhagic Fever with Renal Syndrome (HFRS) Targeted Expanded Program on Immunization (EPI) has been carried out in the 16-60 age population in Yichun City of Jiangxi Province. However, the annual reported incidences of HFRS in Yichun City Increased significantly from 2009 to 2013.
  
  
  METHODS
  The information on HFRS reported cases were obtained from the China Information System for Disease Control and Prevention (CISDCP), and demographic data was collected from the Basic Information System. Hantavirus-specific antigen and antibody of rodent specimens were tested by enzyme-linked immunosorbent assay (ELISA) or immune fluorescent assay.
  
  
  RESULTS
  The annual HFRS incidences among all age subgroups presented growth tendencies in non-EPI targeted regions and EPI targeted regions, except for the EPI target population. The annual incidences of EPI target population were stable at around 10 per 100,000 population from 2008 to 2013. HFRS annual incidence was significantly related to rat virus index among all age subgroups in non-EPI targeted regions and >60 age subgroup in EPI targeted regions.
  
  
  CONCLUSIONS
  HFRS vaccine implement has had a notable effect in HFRS prevention and control.
authors.affiliation: Institution of Communicable Disease Control and Prevention, Jiangxi Province Center for Disease Control and Prevention, Nanchang, Jiangxi, China (mainland).
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institution Of Communicable Disease Control And Prevention, Jiangxi Province Center For Disease Control And Prevention, Nanchang, Jiangxi, China (mainland).
authors.forename: Tianchen
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanchang University, Nanchang, Jiangxi, China (mainland).
authors.forename: Chunyan
authors.initials: C
authors.lastname: Xie
authors.affiliation: Institution Of Communicable Disease Control And Prevention, Jiangxi Province Center For Disease Control And Prevention, Nanchang, Jiangxi, China (mainland).
authors.forename: Yun
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000328:Adult; D017677:Age Distribution; D000818:Animals; D002681:China / Q000453:epidemiology; D002947:Cities / Q000453:epidemiology*; D003710:Demography; D058872:Epidemics; D005260:Female; D006476:Orthohantavirus / Q000276:immunology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000517:prevention & control*; D006801:Humans; D007114:Immunization; D015994:Incidence; D008297:Male; D012377:Rodentia; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D014765:Viral Vaccines
references.citation: BMC Public Health. 2013;13:394
references.pmid: 23622420
references.citation: Virus Res. 2011 Dec;162(1-2):138-47
references.pmid: 21945215
references.citation: Am J Trop Med Hyg. 2013 Nov;89(5):1006-12
references.pmid: 24019443
references.citation: PLoS Negl Trop Dis. 2015 Mar 23;9(3):e0003599
references.pmid: 25799067
references.citation: BMC Public Health. 2010;10:704
references.pmid: 21080975
references.citation: Biomed Environ Sci. 2013 Dec;26(12):972-8
references.pmid: 24393506
references.citation: BMC Infect Dis. 2009;9:109
references.pmid: 19583875
references.citation: Epidemiol Infect. 2015 Jan;143(2):405-11
references.pmid: 24787374
references.citation: BMC Infect Dis. 2014;14:384
references.pmid: 25012160
references.citation: Int J Infect Dis. 2015 Apr;33:212-8
references.pmid: 25704595
references.citation: BMC Infect Dis. 2014;14:301
references.pmid: 24894341
references.citation: PLoS Negl Trop Dis. 2013;7(6):e2260
references.pmid: 23755316
references.citation: BMC Infect Dis. 2014;14:191
references.pmid: 24712579
references.citation: Epidemiol Infect. 2012 May;140(5):851-7
references.pmid: 21791148