title: Nonspecific Effect of Stress on Brain Gray Matter Volume in Drug-naive Female Patients with First Depressive Episode.
abstract: BACKGROUND
  This study aimed to observe the differences in brain gray matter volume in drug-naive female patients after the first episode of major depression with and without stressful life events (SLEs) before the onset of depression.
  
  
  METHODS
  Forty-three drug-naive female patients voluntarily participated in the present study after the first major depressive episode. The life event scale was used to evaluate the severity of the impact of SLEs during 6 months before the onset of the major depressive episode. High-field magnetic resonance imaging (MRI) scans were obtained, and the VBM and SPM8 software process were used to process and analyze the MRI.
  
  
  RESULTS
  Compared to that in patients without SLEs, the volume of brain gray matter was lower in the bilateral temporal lobe, right occipital lobe, and right limbic lobe in the SLE group. However, the gray matter volume did not differ significantly between the two groups after the application of false discovery rate (FDR) correction.
  
  
  CONCLUSIONS
  Although the results of the present study suggest the absence of significant differences in brain gray matter volume between female drug-naive patients after the first episode of major depression with and without SLEs after FDR correction, the study provides useful information for exploring the definitive role of stress in the onset of depression.
authors.forename: Chuan-Jun
authors.initials: CJ
authors.lastname: Zhuo
authors.forename: Hai-Man
authors.initials: HM
authors.lastname: Bian
authors.forename: Yan-Jie
authors.initials: YJ
authors.lastname: Gao
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Ma
authors.forename: Sheng-Zhang
authors.initials: SZ
authors.lastname: Ji
authors.forename: Meng-Yuan
authors.initials: MY
authors.lastname: Yao
authors.forename: Ning
authors.initials: N
authors.lastname: Zhai
authors.forename: Xin-Hai
authors.initials: XH
authors.lastname: Sun
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Ma
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Tian
authors.affiliation: Department of Psychiatry, Jining Medical University, Jining, Shandong 272013, China.
authors.forename: Gong-Ying
authors.initials: GY
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D003863:Depression / Q000503:physiopathology*; D005260:Female; D066128:Gray Matter / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012984:Software; D013312:Stress, Physiological / Q000502:physiology*; D055815:Young Adult
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