title: Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA.
abstract: A fluorophore displaying aggregation-induced emission was introduced at the terminus of branched polyethylenimine (PEI). The formulated polyplex not only demonstrated an improved safety profile and preserved transfection activity but also importantly indicated that the uncomplexed naked DNA rather than the polyplexes translocated into the nucleus.
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology, Tianjin 300384, China. ghhigher@hotmail.com hgao@tjut.edu.cn.
authors.forename: Xiongqi
authors.initials: X
authors.lastname: Han
authors.forename: Qixian
authors.initials: Q
authors.lastname: Chen
authors.forename: Hongguang
authors.initials: H
authors.lastname: Lu
authors.forename: Pan
authors.initials: P
authors.lastname: Guo
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Guolin
authors.initials: G
authors.lastname: Wu
authors.forename: Jianbiao
authors.initials: J
authors.lastname: Ma
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
mesh_terms: D002232:Carbocyanines / Q000737:chemistry*; D002412:Cations / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D005030:Ethylenes / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D018014:Gene Transfer Techniques; D015394:Molecular Structure; D010316:Particle Size; D010957:Plasmids; D013499:Surface Properties
chemical_list: D002232:Carbocyanines; D002412:Cations; D005030:Ethylenes; D005456:Fluorescent Dyes; C085321:cyanine dye 5; D004247:DNA