title: Early Detection of Autism (ASD) by a Non-invasive Quick Measurement of Markedly Reduced Acetylcholine & DHEA and Increased β-Amyloid (1-42), Asbestos (Chrysotile), Titanium Dioxide, Al, Hg & often Coexisting Virus Infections (CMV, HPV 16 and 18), Bacterial Infections etc. in the Brain and Corresponding Safe Individualized Effective Treatment.
abstract: A brief historical background on Autism & some of the important symptoms associated with Autism are summarized. Using strong Electro Magnetic Field Resonance Phenomenon between 2 identical molecules with identical weight (which received U.S. Patent) non-invasively & rapidly we can detect various molecules including neurotransmitters, bacteria, virus, fungus, metals & abnormal molecules. Simple non- invasive measurement of various molecules through pupils & head of diagnosed or suspected Autism patients indicated that in Autism patients following changes were often found: 1) Acetylcholine is markedly reduced; 2) Alzheimer's disease markers (i.e. β-Amyloid (1-42), Tau Protein, Apolipoprotein (Apo E4)) are markedly increased; 3) Chrysotile Asbestos is increased; 4) Titanium Dioxide (TiO2) is moderately increased; 5) Al is moderately increased; 6) Hg is moderately increased; 7) Dopamine, Serotonin & GABA are significantly reduced (up to about 1/10 of normal); 8) Often viral infections (such as CMV, HHV-6, HPV-16, HPV-18, etc.), and Bacterial infections (such as Chlamydia trachomatis, Mycobacterium TB, Borrelia Burgdorferi, etc.) coexist. Research by others on Autism spectrum disorder (ASD) shows that it is a group of complex neurodevelopmental disorders, with about 70% of ASD patients also suffering from gastro-intestinal problems. While Alzheimer disease (AD) is characterized by formation of 1) Amyloid plaques, 2) Neurofibrillary tangles inside of neurons, and 3) Loss of connections between neurons. More than 90% of AD develops in people over the age of 65. These 3 characteristics often progressively worsen over time. Although Autism Spectrum Disorder and Alzheimer's disease are completely different diseases they have some similar biochemical changes. Eight examples of such measurement & analysis are shown for comparison. Most of Autism patients improved significantly by removing the source or preventing intake of Asbestos, TiO2, Al & Hg or enhancing urinary output of above abnormal substances & coexisting infections, if treatment is given early. When HPV-16 & HPV-18 coexist, at triangular central area of the top of head, in addition to inability to talk, severe neuromuscular problems of lower extremity were found to also exist. However, if treatment is given 3-4 years after onset of Autism symptoms, even when successful biochemical reduction of above abnormal substances occurs, clinical improvement is less significant, since permanent damage in brain tissue seems to already exist. Therefore, early diagnosis & early treatment is very important for both Autism & Alzheimer's disease. In addition the optimal doses of Vitamin D3 and Taurine may play an important role in the future treatment of Autism, Alzheimer's Disease and memory disturbances by significantly increasing Acetylcholine and DHEA levels, enhancing the excretion of toxic substances in the urine, as well as having an anticancer effect.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Omura
authors.forename: Dominic
authors.initials: D
authors.lastname: Lu
authors.forename: Marilyn K
authors.initials: MK
authors.lastname: Jones
authors.forename: Ahdallah
authors.initials: A
authors.lastname: Nihrane
authors.forename: Harsha
authors.initials: H
authors.lastname: Duvvi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shimotsuura
authors.forename: Motomu
authors.initials: M
authors.lastname: Ohki
mesh_terms: D000109:Acetylcholine / Q000032:analysis / Q000378:metabolism; D000293:Adolescent; D000535:Aluminum / Q000032:analysis / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000378:metabolism; D001194:Asbestos / Q000032:analysis / Q000378:metabolism; D001321:Autistic Disorder / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D001424:Bacterial Infections / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D001921:Brain / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003687:Dehydroepiandrosterone / Q000032:analysis / Q000378:metabolism; D042241:Early Diagnosis; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D008628:Mercury / Q000032:analysis / Q000378:metabolism; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D010446:Peptide Fragments / Q000032:analysis / Q000378:metabolism; D011680:Pupil; D014025:Titanium / Q000032:analysis / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D001194:Asbestos; C009495:titanium dioxide; D003687:Dehydroepiandrosterone; D000535:Aluminum; D014025:Titanium; D008628:Mercury; D000109:Acetylcholine