title: DNA based arithmetic function: a half adder based on DNA strand displacement.
abstract: Biomolecular programming utilizes the reactions and information stored in biological molecules, such as proteins and nucleic acids, for computational purposes. DNA has proven itself an excellent candidate for building logic operating systems due to its highly predictable molecular behavior. In this work we designed and realized an XOR logic gate and an AND logic gate based on DNA strand displacement reactions. These logic gates utilize ssDNA as input and output signals. The XOR gate and the AND gate were used as building blocks for constructing a half adder logic circuit, which is a primary step in constructing a full adder, a basic arithmetic unit in computing. This work provides the field of DNA molecular programming with a potential universal arithmetic tool.
authors.affiliation: Center of Molecular Design and Biomimetics at The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA. weili6@asu.edu yan_liu@asu.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Center of Molecular Design and Biomimetics at The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA. weili6@asu.edu yan_liu@asu.edu.
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Center of Molecular Design and Biomimetics at The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA. weili6@asu.edu yan_liu@asu.edu.
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
authors.affiliation: Center of Molecular Design and Biomimetics at The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA. weili6@asu.edu yan_liu@asu.edu.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry*
chemical_list: D004247:DNA