title: Base-Free Direct Synthesis of Alkynylphosphonates from Alkynes and H-Phosphonates Catalyzed by Cu2O.
abstract: A simple and mild methodology for the direct synthesis of alkynylphosphonates is presented. The reaction of a variety of terminal alkynes with dialkyl phosphites in the presence Cu2O (14 mol %) led to the formation of the corresponding alkynylphosphonates in good to excellent yields. Reactions are performed under air, in acetonitrile as solvent, and in the absence of base or ligand additives. This new methodology is compatible with the presence of a wide variety of functional groups on the starting alkynes and can be scaled up to a gram scale.
authors.affiliation: Instituto de Química del Sur, INQUISUR (CONICET-UNS), Departamento de Química, Universidad Nacional del Sur , Avenida Alem 1253, 8000 Bahía Blanca, Argentina.
authors.forename: Yanina
authors.initials: Y
authors.lastname: Moglie
authors.affiliation: Instituto de Química del Sur, INQUISUR (CONICET-UNS), Departamento de Química, Universidad Nacional del Sur , Avenida Alem 1253, 8000 Bahía Blanca, Argentina.
authors.forename: Evangelina
authors.initials: E
authors.lastname: Mascaró
authors.affiliation: Instituto de Química del Sur, INQUISUR (CONICET-UNS), Departamento de Química, Universidad Nacional del Sur , Avenida Alem 1253, 8000 Bahía Blanca, Argentina.
authors.forename: Victoria
authors.initials: V
authors.lastname: Gutierrez
authors.affiliation: Instituto de Síntesis Orgánica (ISO) and Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante , Apdo. 99, 03080, Alicante, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Alonso
authors.affiliation: Instituto de Química del Sur, INQUISUR (CONICET-UNS), Departamento de Química, Universidad Nacional del Sur , Avenida Alem 1253, 8000 Bahía Blanca, Argentina.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Radivoy