title: Hepatitis C virus infection from the perspective of heterologous immunity.
abstract: Heterologous immunity can impact the natural course of subsequent infections by different mechanisms such as polarization of TH1/TH2 responses, induction of cytokines and T cell cross-reactivity. In the case of hepatitis C virus (HCV) infection, heterologous immunity helps to explain the high variability in clinical outcomes. This review discusses how other infections can alter the natural course of hepatitis C and how HCV infection influence unrelated infections.
authors.affiliation: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, Germany; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Germany. Electronic address: Cornberg.markus@mh-hannover.de.
authors.forename: Markus
authors.initials: M
authors.lastname: Cornberg
authors.affiliation: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, Germany. Electronic address: wedemeyer.heiner@mh-hannover.de.
authors.forename: Heiner
authors.initials: H
authors.lastname: Wedemeyer
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology / Q000378:metabolism; D003429:Cross Reactions / Q000276:immunology; D016174:Hepacivirus / Q000502:physiology*; D006526:Hepatitis C / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D064789:Immunity, Heterologous; D037182:T-Cell Antigen Receptor Specificity / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism