title: Pathogenicity of the Korean H5N8 highly pathogenic avian influenza virus in commercial domestic poultry species.
abstract: In 2014, the highly pathogenic avian influenza (HPAI) virus H5N8 triggered outbreaks in wild birds and poultry farms in South Korea. In the present study, we investigated the pathogenicity of the H5N8 HPAI virus, belonging to the clade 2.3.4.4, in different species of poultry. For this, we examined clinical signs and viral shedding levels following intranasal inoculation of the virus in 3-week-old commercial layer chickens and quails, 10-week-old Korean native chickens, and 8-week-old Muscovy ducks. Intranasal inoculation with 10(6.0) viruses at 50% egg-infective dose resulted in 100% mortality in the layer chickens (8/8) and quails (4/4), but 60% and 0% deaths in the Korean native chickens (3/5) and Muscovy ducks (0/4), respectively. In addition, transmission of the inoculated virus to contact-exposed birds was evident in all the species used in this study. Based on our results, we conclude that the H5N8 HPAI virus has lower pathogenicity and transmissibility in poultry species compared with previously reported H5N1 HPAI viruses.
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: Dong-Hun
authors.initials: DH
authors.lastname: Lee
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Kwon
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Noh
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: Jae-Keun
authors.initials: JK
authors.lastname: Park
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: Seong-Su
authors.initials: SS
authors.lastname: Yuk
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: Tseren-Ochir
authors.initials: TO
authors.lastname: Erdene-Ochir
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: Joong-Bok
authors.initials: JB
authors.lastname: Lee
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Park
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Choi
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Lee
authors.affiliation: a Avian Diseases Laboratory , College of Veterinary Medicine, Konkuk University , Seoul , Republic of Korea.
authors.forename: Chang-Seon
authors.initials: CS
authors.lastname: Song
mesh_terms: D000818:Animals; D002645:Chickens / Q000821:virology; D004196:Disease Outbreaks / Q000662:veterinary; D004372:Ducks / Q000821:virology; D000071225:Influenza A Virus, H5N8 Subtype / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000821:virology*; D011200:Poultry / Q000821:virology*; D011201:Poultry Diseases / Q000821:virology*; D011784:Quail / Q000821:virology; D056910:Republic of Korea / Q000453:epidemiology; D014774:Virulence; D017201:Virus Shedding
keywords: Avian influenza; H5N8; Korea; poultry; thogenicity