title: Immunomodulatory impression of anti and pro-inflammatory cytokines in relation to humoral immunity in human scabies.
abstract: The chief manifestations of scabies are mediated through hypersensitivity-like reactions and immune responses which are so far not well understood and remain poorly characterized. The aim of this study is to investigate the role of inflammatory cytokines in relation to humoral immunity in patients with scabies. Serum levels of total IgE, specific IgG, IL-10, IL-6, INF-γ, and TNF-α were investigated in a cross-sectional study including 37 patients with manifestations suggestive of scabies and serologically positive for anti-Sarcoptes IgG, in addition to 20 healthy controls. The median value of total IgE was 209 (range, 17-1219 IU/mL), reflecting its wide range within cases. IL-10 showed significant higher levels (287 ±: 139) in cases than in controls (17.4 ± 11.32). A positive correlation was reported between total IgE and severity of manifestations (r = 0.429, P <0.005). A significant positive correlation was observed between total IgE and both IgG and IL-6. On the contrary, a negative correlation was recorded between IL-6 and TNF-α which makes us suggested anti-inflammatory rather than pro-inflammatory effect of IL-6. Moreover, a negative correlation was noticed between the anti-inflammatory cytokine IL-10 and severity of manifestations, specific IgG, total IgE, and INF-γ. Therefore, the current study theorized a regulatory role of IL-10 in inflammatory responses of scabietic patients suggesting further future analysis of its therapeutic potential.
authors.affiliation: Parasitology Department, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Amany Ahmed
authors.initials: AA
authors.lastname: Abd El-Aal
authors.affiliation: Parasitology Department, Faculty of Medicine, Cairo University, Egypt mahassan@kasralainy.edu.eg.
authors.forename: Marwa Adel
authors.initials: MA
authors.lastname: Hassan
authors.affiliation: Dermatology Department, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Heba Ismail
authors.initials: HI
authors.lastname: Gawdat
authors.affiliation: Parasitology Department, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Meran Ahmed
authors.initials: MA
authors.lastname: Ali
authors.affiliation: Clinical pathology Department, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Manal
authors.initials: M
authors.lastname: Barakat
mesh_terms: D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007155:Immunologic Factors / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D012532:Scabies / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D016207:Cytokines; D007074:Immunoglobulin G; D007155:Immunologic Factors; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007073:Immunoglobulin E; D007371:Interferon-gamma
keywords: immune response; inflammatory cytokines; interferon; interleukin; scabies
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