title: The short-lived African turquoise killifish: an emerging experimental model for ageing.
abstract: Human ageing is a fundamental biological process that leads to functional decay, increased risk for various diseases and, ultimately, death. Some of the basic biological mechanisms underlying human ageing are shared with other organisms; thus, animal models have been invaluable in providing key mechanistic and molecular insights into the common bases of biological ageing. In this Review, we briefly summarise the major applications of the most commonly used model organisms adopted in ageing research and highlight their relevance in understanding human ageing. We compare the strengths and limitations of different model organisms and discuss in detail an emerging ageing model, the short-lived African turquoise killifish. We review the recent progress made in using the turquoise killifish to study the biology of ageing and discuss potential future applications of this promising animal model.
authors.affiliation: Max Planck Institute for Biology of Ageing, D50931, Cologne, Germany Department of New Biology, DGIST, 711-873, Daegu, Republic of Korea.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of New Biology, DGIST, 711-873, Daegu, Republic of Korea Center for Plant Aging Research, Institute for Basic Science, 711-873, Daegu, Republic of Korea.
authors.forename: Hong Gil
authors.initials: HG
authors.lastname: Nam
authors.affiliation: Max Planck Institute for Biology of Ageing, D50931, Cologne, Germany Dario.Valenzano@age.mpg.de.
authors.forename: Dario Riccardo
authors.initials: DR
authors.lastname: Valenzano
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D023781:Fundulidae / Q000502:physiology*; D008018:Life Cycle Stages; D023421:Models, Animal
keywords: Age-associated diseases; Ageing; Longevity; Model organisms; Nothobranchius furzeri; Turquoise killifish
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