title: Effect of HCV on fasting glucose, fasting insulin and peripheral insulin resistance in first 5 years of infection.
abstract: OBJECTIVE
  To assess the effects of hepatitis C virus infection in the first 5 years on fasting glucose, fasting insulin and peripheral insulin resistance.
  
  
  METHODS
  The case-control study was conducted at the Army Medical College, Rawalpindi, from December 2011 to November 2012, and comprised subjects recruited from a government hospital in Rawalpindi. The subjects included known cases of hepatitis C virus infection for at least 5 years, and normal healthy controls. Fasting blood samples of all the subjects were collected and analysed for serum fasting insulin and serum fasting glucose levels. Homeostatic model assessment-Insulin resistance was calculated SPSS 11 was used for statistical analysis.
  
  
  RESULTS
  Of the 30 subjects, 20(66.6%) were cases, while 10(33.3%) were controls. Serum fasting glucose mean level in cases was 89.55±9.53 compared to 84.40±9.80 in the controls (p=0.188). The mean serum fasting insulin in controls was 7.52±3.23 and 6.79±3.30 in cases (p=0.567). Homeostatic model assessment-Insulin resistance level in controls was 1.60±0.76 and In the cases it was 1.49±0.74 (p=0.695).
  
  
  CONCLUSIONS
  Peripheral insulin resistance and development of type 2 diabetes as a complication of hepatitis C virus infection was not likely at least within the first five years of infection.
authors.affiliation: Department of Biochemistry & Molecular Biology, Army Medical College, National University of Sciences & Technology, Rawalpindi, Pakistan.
authors.forename: Naeema
authors.initials: N
authors.lastname: Ahmed
authors.affiliation: Department of Biochemistry & Molecular Biology, Army Medical College, National University of Sciences & Technology, Rawalpindi, Pakistan.
authors.forename: Amir
authors.initials: A
authors.lastname: Rashid
authors.affiliation: Department of Biochemistry, Islamic International Medical College, Riphah University, Rawalpindi, Pakistan.
authors.forename: Abdul Khaliq
authors.initials: AK
authors.lastname: Naveed
authors.affiliation: Department of Biochemistry & Molecular Biology, Army Medical College, National University of Sciences & Technology, Rawalpindi, Pakistan.
authors.forename: Qudsia
authors.initials: Q
authors.lastname: Bashir
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D042241:Early Diagnosis; D061345:Early Medical Intervention; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010154:Pakistan
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Hepatitis C Virus (HCV), Peripheral insulin resistance (IR), Type2 diabetes mellitus (T2DM), Homeostatic model assessment-Insulin resistance (HOMA-IR).