title: Cutaneous CD30-Positive Lymphoproliferative Disorders.
abstract: Cutaneous CD30+ lymphoproliferative disorders are the second most common types of cutaneous T-cell lymphomas. They represent a well-defined spectrum encompassing lymphomatoid papulosis (LyP), primary cutaneous anaplastic large-cell lymphoma (pcALCL), and borderline lesions. They share the expression of CD30 as a common phenotypic hallmark, but they differ in their clinical presentation, course, and histologic features. New variants have been recently identified, including CD8+ epidermotropic LyP type D, angioinvasive LyP type E, and ALK-positive pcALCL. This review describes clinical, histopathologic, and phenotypic variants; their differential diagnoses (benign and malignant); and the role of CD30 as a diagnostic, prognostic, and therapeutic marker.
authors.affiliation: Kempf und Pfaltz, Histologische Diagnostik, Seminarstrasse 1, Zürich CH-8042, Switzerland; Department of Dermatology, University Hospital, Zürich CH-8091, Switzerland. Electronic address: kempf@kempf-pfaltz.ch.
authors.forename: Werner
authors.initials: W
authors.lastname: Kempf
keywords: Anaplastic large-cell lymphoma; Borderline; CD30; Clinico-pathological correlation; Cutaneous; Lymphoma; Lymphomatoid papulosis; Systemic