title: Specific Reaction Patterns to Distinct Positive Emotional Cues Related to Incentive Motivation in Dependence of the Taq1A-Polymorphism: Molecular Genetic Associations of Early and Late Event-Related Potentials.
abstract: OBJECTIVE
  Early and late event-related potential (ERP) responses, representing early subconscious and late motivational processes, were recorded for positive emotional words related to 'wanting' and 'liking', in dependence of the dopamine-related Taq1A genotype (ANKK1/DRD2). Research suggests that 'wanting' as opposed to 'liking' is related to dopaminergic processes. Therefore, it was hypothesized that risk allele carriers of the Taq1A polymorphism exhibit late ERP changes in reaction to words representing incentive motivation, i.e. 'wanting' (word categories 'lust' and 'anticipation'), but not to words representing 'liking' ('closeness').
  
  
  METHODS
  Seventy-two male participants performed an emotional-word Stroop task during EEG recording and were genotyped according to the Taq1A polymorphism of ANKK1/DRD2.
  
  
  RESULTS
  Positive emotional words related to anticipation and lust revealed blunted responses in the late positive potential (LPP) in carriers of the A1 allele, an effect absent in response to 'liking'-related words. These differences were not evident in the earlier posterior negativity (EPN).
  
  
  CONCLUSIONS
  As no differences in dependence of the Taq1A genotype were observed in reaction to 'wanting'- and 'liking'-related words in the EPN, but merely in the LPP, it can be assumed that incentive-motivational stimuli only modify motivation-related ERP responses in carriers of the A1 allele of the Taq1A polymorphism, indicating the role of dopamine in late ERP components.
authors.affiliation: Department of Personality and Biological Psychology, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: Aisha J L
authors.initials: AJ
authors.lastname: Munk
authors.forename: Catrin
authors.initials: C
authors.lastname: Wielpuetz
authors.forename: Roman
authors.initials: R
authors.lastname: Osinsky
authors.forename: Erik M
authors.initials: EM
authors.lastname: Müller
authors.forename: Phillip
authors.initials: P
authors.lastname: Grant
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hennig
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002540:Cerebral Cortex / Q000502:physiology*; D003463:Cues; D004569:Electroencephalography; D004644:Emotions / Q000502:physiology*; D005071:Evoked Potentials; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D009042:Motivation / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000502:physiology*; D057190:Stroop Test; D055815:Young Adult
chemical_list: C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2; C489948:ANKK1 protein, human; D017346:Protein Serine-Threonine Kinases