title: ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity.
abstract: We study the associations between apoA-II fractional catabolic rate (FCR) and the kinetics of VLDL subspecies and apoA-I and show that, in abdominally obese individuals, apoA-II FCR is positively and independently associated with both apoA-I FCR and VLDL1-TG indirect FCR.
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vergès
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Martin
authors.initials: M
authors.lastname: Adiels
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Jan
authors.initials: J
authors.lastname: Boren
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Peter Hugh
authors.initials: PH
authors.lastname: Barrett
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Watts
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Dick
authors.initials: D
authors.lastname: Chan
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Laurence
authors.initials: L
authors.lastname: Duvillard
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Sanni
authors.initials: S
authors.lastname: Söderlund
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Niina
authors.initials: N
authors.lastname: Matikainen
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Juhani
authors.initials: J
authors.lastname: Kahri
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Nina
authors.initials: N
authors.lastname: Lundbom
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Jesper
authors.initials: J
authors.lastname: Lundbom
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Hakkarainen
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Serge
authors.initials: S
authors.lastname: Aho
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Simoneau-Robin
authors.affiliation: Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.
authors.forename: Marja-Riitta
authors.initials: MR
authors.lastname: Taskinen
mesh_terms: D000328:Adult; D000368:Aged; D016633:Apolipoprotein A-II / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007700:Kinetics; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000150:complications*
chemical_list: D016633:Apolipoprotein A-II; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL