title: Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms.
abstract: Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in animals with experimental ALD in the past, there is still no FDA (Food and Drug Administration) approved therapy for any stage of ALD. With the increasing recognition of the importance of gut microbiota in the onset and development of a variety of diseases, the potential use of probiotics in ALD is receiving increasing investigative and clinical attention. In this review, we summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients. Potential mechanisms underlying the probiotic function are also discussed.
authors.affiliation: College of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Departments of Medicine, Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
authors.forename: Fengyuan
authors.initials: F
authors.lastname: Li
authors.affiliation: College of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
authors.forename: Kangmin
authors.initials: K
authors.lastname: Duan
authors.affiliation: College of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Cuiling
authors.initials: C
authors.lastname: Wang
authors.affiliation: Departments of Medicine, Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA; Robley Rex Veterans Affairs Medical Center, Louisville, KY 40202, USA.
authors.forename: Craig
authors.initials: C
authors.lastname: McClain
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Departments of Medicine, Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
authors.forename: Wenke
authors.initials: W
authors.lastname: Feng
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