title: Lack of association between IL-10 and IL-18 gene promoter polymorphisms and Parkinson's disease with cognitive impairment in a Chinese population.
abstract: Inflammatory processes have been implicated in the pathogenesis of Parkinson's disease (PD), including the development of PD-associated cognitive impairment. Whether genetic variants of inflammatory cytokine genes influence the risk of cognitive impairment in PD is unknown. In this study, we investigated single nucleotide polymorphisms (SNPs) in the IL-10 promoter (rs1800871 and rs1800872) and in the IL-18 promoter (rs1946518 and rs187238) in a Han Chinese cohort (N = 933). PD patients (N = 460) and controls (N = 473) were genotyped. Additionally, 268 PD patients were divided into three subgroups [cognitively normal (PD-NC), mild cognitive impairment (PD-MCI), and with dementia (PD-D)] on the basis of their performance on a battery of neuropsychological tests. No associations were found between the aforementioned polymorphisms and cognitive impairment in PD; thus no confirmatory evidence for the hypothesis of IL-10 and IL-18 alleles modulating the risk of cognitive impairment in Chinese PD patients was obtained.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.|State Key Laboratory of Medical Genetics, Changsha, 410008 Hunan, People's Republic of China.|Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008 Hunan, People's Republic of China.|Neurodegenerative Disorders Research Center, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Kang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.|Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008 Hunan, People's Republic of China.|Neurodegenerative Disorders Research Center, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Qiying
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.|Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008 Hunan, People's Republic of China.|Neurodegenerative Disorders Research Center, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Neurology, Henan provincial people's hospital, Zhengzhou, 450003, Henan, People's Republic of China.
authors.forename: Changshui
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.|Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008 Hunan, People's Republic of China.|Neurodegenerative Disorders Research Center, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Xinxiang
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.|State Key Laboratory of Medical Genetics, Changsha, 410008 Hunan, People's Republic of China.|Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008 Hunan, People's Republic of China.|Neurodegenerative Disorders Research Center, Central South University, Changsha, 410008 Hunan, People's Republic of China.
authors.forename: Beisha
authors.initials: B
authors.lastname: Tang
mesh_terms: D000368:Aged; D044466:Asian People; D002681:China; D060825:Cognitive Dysfunction / Q000235:genetics*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020382:Interleukin-18 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: C508609:IL10 protein, human; C000589760:IL18 protein, human; D020382:Interleukin-18; D016753:Interleukin-10
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