title: Pt74Ag26 nanoparticle-decorated ultrathin MoS2 nanosheets as novel peroxidase mimics for highly selective colorimetric detection of H2O2 and glucose.
abstract: To extend the functionalities of two-dimensional graphene-like layered compounds as versatile materials, the modification of transition metal dichalcogenide nanosheets such as MoS2 with metal nanoparticles is of great and widespread interest. However, few studies are available on the preparation of bimetallic nanoparticles supported on MoS2. Herein, a facile and efficient method to synthesize MoS2-PtAg nanohybrids by decorating ultrathin MoS2 nanosheets with octahedral Pt74Ag26 alloy nanoparticles has been reported. The as-prepared MoS2-Pt74Ag26 nanohybrids were investigated as novel peroxidase mimics to catalyze the oxidation of classical peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of H2O2, producing a blue colored reaction and exhibiting typical Michaelis-Menten kinetics. MoS2-Pt74Ag26 has a higher affinity for H2O2 than horseradish peroxidase (HRP) and a higher vmax value with TMB as the substrate than MoS2. The improved catalytic activity of hybrids for colorimetric reactions could be attributed to the synergistic effects of octahedral Pt74Ag26 nanoparticles and ultrathin MoS2 nanosheets as supports. Meanwhile, the generation of active oxygen species (˙OH) by H2O2 decomposition with MoS2-Pt74Ag26 was responsible for the oxidation of TMB. On the basis of these findings, a colorimetric method based on MoS2-Pt74Ag26 nanohybrids that is highly sensitive and selective was developed for glucose detection. Lower values of the limit of detection (LOD) were obtained, which is more sensitive than MoS2 nanosheets.
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China. yangr@nanoctr.cn wangch@nanoctr.cn.
authors.forename: Shuangfei
authors.initials: S
authors.lastname: Cai
authors.forename: Qiusen
authors.initials: Q
authors.lastname: Han
authors.forename: Cui
authors.initials: C
authors.lastname: Qi
authors.forename: Zheng
authors.initials: Z
authors.lastname: Lian
authors.forename: Xinghang
authors.initials: X
authors.lastname: Jia
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry*; D005947:Glucose / Q000032:analysis*; D006861:Hydrogen Peroxide / Q000032:analysis*; D008567:Membranes, Artificial; D053768:Metal Nanoparticles / Q000737:chemistry*; D008982:Molybdenum / Q000737:chemistry*; D009195:Peroxidase / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: D004220:Disulfides; D008567:Membranes, Artificial; D012834:Silver; D010984:Platinum; D008982:Molybdenum; D006861:Hydrogen Peroxide; D009195:Peroxidase; D005947:Glucose; C082964:molybdenum disulfide