title: Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder.
abstract: BACKGROUND
  Posttraumatic stress disorder (PTSD) is a disabling and prevalent psychiatric disorder with limited effective treatment options. In addition to the clinical features of the disease, pathologic changes in the electroencephalogram (EEG), including decreased alpha power, have been reported.
  
  
  OBJECTIVE
  To determine if magnetic brain stimulation can induce normalization of EEG abnormalities and improve clinical symptoms in PTSD in a preliminary, open-label evaluation.
  
  
  METHODS
  We reviewed prospectively-collected data on 21 veterans that were consecutively-treated for PTSD. Magnetic resonance therapy (MRT) was administered for two weeks at treatment frequencies based on frequency-domain analysis of each patient's dominant alpha-band EEG frequencies and resting heart rate. Patients were evaluated on the PTSD checklist (PCL-M) and pre- and post-treatment EEGs before and after MRT.
  
  
  RESULTS
  Of the 21 patients who initiated therapy, 16 completed treatment. Clinical improvements on the PCL-M were seen in these 16 patients, with an average pre-treatment score of 54.9 and post-treatment score of 31.8 (P < 0.001). In addition, relative global EEG alpha-band (8 - 13 Hz) power increased from 32.0 to 38.5 percent (P = 0.013), and EEG delta-band (1 - 4 Hz) power decreased from 32.3 percent to 26.8 percent (P = 0.028).
  
  
  CONCLUSIONS
  These open-label data show trends toward normalization of EEG and concomitant clinical improvement using magnetic stimulation for PTSD.
authors.affiliation: Center for Neurorestoration, University of Southern California, Los Angeles, USA; Orange County Neurosurgical Associates, Mission Viejo, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Taghva
authors.affiliation: Newport Brain Research Laboratory, Newport Beach, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Silvetz
authors.affiliation: Center for Neurorestoration, University of Southern California, Los Angeles, USA; Newport Brain Research Laboratory, Newport Beach, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Ring
authors.affiliation: Orange County Neurosurgical Associates, Mission Viejo, USA.
authors.forename: Keun-Young A
authors.initials: KY
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, University of California, San Diego, La Jolla, USA.
authors.forename: Kevin T
authors.initials: KT
authors.lastname: Murphy
authors.affiliation: Center for Neurorestoration, University of Southern California, Los Angeles, USA; Department of Neurosurgery, University of Southern California, Los Angeles, USA.
authors.forename: Charles Y
authors.initials: CY
authors.lastname: Liu
authors.affiliation: Center for Neurorestoration, University of Southern California, Los Angeles, USA; Newport Brain Research Laboratory, Newport Beach, USA; Department of Psychiatry and Human Behavior, University of California, Irvine, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jin
keywords: Electroencephalogram; Magnetic Resonance Therapy; Neuromodulation; Posttraumatic Stress Disorder; Prefrontal Cortex; Transcranial Magnetic Stimulation
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