title: One-Pot Sequential Propargylation/Cycloisomerization: A Facile [4+2]-Benzannulation Approach to Carbazoles.
abstract: A novel one-pot [4+2]-benzannulation approach to substituted carbazoles is accomplished by acid-catalyzed C3-propargylation of 2-alkenyl/aryl indoles with 1-aryl propargylic alcohols, followed by cycloisomerization. A variety of 2-alkenylated indoles and 2-aryl/heteroaryl indoles successfully participated in this tandem reaction with 1-aryl/heteroaryl propargylic alcohols to provide diversely substituted and annulated carbazoles, as well as an aza[5]helicene.
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India. rajireddy@iict.res.in.
authors.forename: Chada
authors.initials: C
authors.lastname: Raji Reddy
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India.
authors.forename: Reddi
authors.initials: R
authors.lastname: Rani Valleti
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India.
authors.forename: Uredi
authors.initials: U
authors.lastname: Dilipkumar
keywords: benzannulation; carbazoles; cycloisomerization; metal-free synthesis; propargylation