title: Pituitary Prolactinoma Imaged by 99mTc-Sestamibi SPECT/CT in a Multiple Endocrine Neoplasia Type 1 Patient.
abstract: A 35-year-old woman who had undergone bilateral inferior parathyroidectomy for primary hyperparathyroidism was referred to our hospital to evaluate the cause of irregular menses, galactorrhea, and paroxysmal headache. Multiple endocrine neoplasia type 1 was then suspected for the high levels of plasma prolactin, parathyroid hormone, serum calcium, insulin, and related symptoms. A Tc-sestamibi SPECT/CT acquired to evaluate parathyroid glands unexpectedly revealed an increased accumulation in the pituitary gland, which was further confirmed by enhanced magnetic resonance imaging as a pituitary microadenoma. Bromocriptine treatment gradually reduced the prolactin level.
authors.affiliation: From the Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Pan
authors.forename: Jing
authors.initials: J
authors.lastname: Lv
authors.forename: Rui
authors.initials: R
authors.lastname: Guo
authors.forename: Mengyi
authors.initials: M
authors.lastname: Pan
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D006934:Hypercalcemia / Q000097:blood; D006946:Hyperinsulinism / Q000097:blood; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000601:surgery; D006966:Hyperprolactinemia / Q000097:blood; D008279:Magnetic Resonance Imaging; D018761:Multiple Endocrine Neoplasia Type 1 / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D010280:Parathyroid Glands / Q000000981:diagnostic imaging / Q000601:surgery; D016105:Parathyroidectomy; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology; D015175:Prolactinoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology; D019275:Radiopharmaceuticals; D000072098:Single Photon Emission Computed Tomography Computed Tomography; D017256:Technetium Tc 99m Sestamibi
chemical_list: D006727:Hormone Antagonists; D019275:Radiopharmaceuticals; D001971:Bromocriptine; D017256:Technetium Tc 99m Sestamibi