title: Gait variability across the disability spectrum in people with multiple sclerosis.
abstract: BACKGROUND
  An alternative method suggested to assess changes in walking in people with multiple sclerosis (PwMS) is evaluating gait variability. This is a credible option since gait variability reflects to some degree the quality of gait control.
  
  
  OBJECTIVE
  Examine the impact of disability on gait variability in PwMS.
  
  
  METHODS
  In this cross-sectional study, the data pool was divided into seven levels of disability based on the Expanded Disability Status Scale (EDSS) score, ranging from 0 to 6.5. Gait variability was studied using an electronic mat.
  
  
  RESULTS
  The final analysis included 381 PwMS (249 women); mean age 44.0years. Non-significant differences were observed between the EDSS subgroups at the lower end of the spectrum (EDSS 0-3.5) in all gait variability parameters. In contrast, PwMS in the EDSS 5.0-5.5 group demonstrated a significant increase in variability of step length (~151%), single support (~93%) and step time (142%) compared with those who scored 0-3.5. Moreover, participants in the EDSS 5.0-5.5 group had elevated step length variability compared to the EDSS 4.0-4.5 group (9.3 (S.E.=2.2) vs. 5.5 (S.E.=0.4), P-value=0.005).
  
  
  CONCLUSIONS
  We encourage clinicians to follow-up on the gait variability score as it appears to reflect mobility deterioration in PwMS.
authors.affiliation: Department of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University, Israel; Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel. Electronic address: alkalron@gmail.com.
authors.forename: Alon
authors.initials: A
authors.lastname: Kalron
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D006233:Persons with Disabilities; D005260:Female; D005684:Gait / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology*; D016138:Walking / Q000502:physiology*
keywords: EDSS; Gait; Gait variability; Multiple sclerosis; Neurological; Walking