title: Unguisin F, a new cyclic peptide from the endophytic fungus Mucor irregularis.
abstract: The new cyclic heptapeptide unguisin F (1) and the known congener unguisin E (2), were obtained from the endophytic fungus Mucor irregularis, isolated from the medicinal plant Moringa stenopetala, collected in Cameroon. The structure of the new compound was unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configuration of the amino acid residues of 1 and 2 was determined using Marfey's analysis. Compounds 1 and 2 were evaluated for their antibacterial and antifungal potential, but failed to display significant activities.
authors.forename: Sergi H
authors.initials: SH
authors.lastname: Akone
authors.forename: Georgios
authors.initials: G
authors.lastname: Daletos
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification; D001419:Bacteria / Q000187:drug effects / Q000472:pathogenicity; D005658:Fungi / Q000187:drug effects / Q000472:pathogenicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000737:chemistry* / Q000472:pathogenicity; D009091:Mucormycosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010456:Peptides, Cyclic