title: Stability indicating methods for the analysis of cefprozil in the presence of its alkaline induced degradation product.
abstract: Three simple, specific, accurate and precise spectrophotometric methods were developed for the determination of cefprozil (CZ) in the presence of its alkaline induced degradation product (DCZ). The first method was the bivariate method, while the two other multivariate methods were partial least squares (PLS) and spectral residual augmented classical least squares (SRACLS). The multivariate methods were applied with and without variable selection procedure (genetic algorithm GA). These methods were tested by analyzing laboratory prepared mixtures of the above drug with its alkaline induced degradation product and they were applied to its commercial pharmaceutical products.
authors.affiliation: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751 Nasr City, Cairo, Egypt.
authors.forename: Khalid A M
authors.initials: KA
authors.lastname: Attia
authors.affiliation: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751 Nasr City, Cairo, Egypt.
authors.forename: Mohammed W I
authors.initials: MW
authors.lastname: Nassar
authors.affiliation: Analytical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), 12582 Al Hadaba Al Wosta, Cairo, Egypt.
authors.forename: Mohamed B
authors.initials: MB
authors.lastname: El-Zeiny
authors.affiliation: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751 Nasr City, Cairo, Egypt. Electronic address: Ahmedserag777@hotmail.com.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Serag
mesh_terms: D000465:Algorithms; D000468:Alkalies / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002511:Cephalosporins / Q000737:chemistry*; D004355:Drug Stability; D016018:Least-Squares Analysis; D015999:Multivariate Analysis; D013053:Spectrophotometry / Q000379:methods*; D000097670:Cefprozil
chemical_list: D000468:Alkalies; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097670:Cefprozil
keywords: Bivariate; Cefprozil; Genetic algorithm; PLS; SRACLS; Stability indicating methods