title: Concurrent tamoxifen-related Müllerian adenofibromas in uterus and ovary.
abstract: Tamoxifen is a widely used in anti-oestrogen treatment of breast cancer. Previous reports showed that tamoxifen is associated with proliferative endometrial lesions. We herein reported an unusual case of concurrent hyperplastic lesions in the uterine cavity and right ovary in a 45-year-old woman with tamoxifen therapy. Regular vaginal ultrasonography showed the progressive endometrial thickening and right ovary enlargement during the period of drug use. Both lesions in the uterine cavity and right ovary showed characteristics resembling that of Müllerian adenofibroma. There were also foci of endometriosis in her bilateral ovarian surfaces. We suggest that women taking tamoxifen with a known history of endometriosis should be followed with transvaginal ultrasonography periodically.
authors.affiliation: Department of Pathology, The Affiliated Women's Hospital, School of Medicine, Zhejiang University Hangzhou 310003, PR China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Pathology, The Affiliated Women's Hospital, School of Medicine, Zhejiang University Hangzhou 310003, PR China.
authors.forename: Xiaoduan
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Pathology, The Affiliated Women's Hospital, School of Medicine, Zhejiang University Hangzhou 310003, PR China.
authors.forename: Bingjian
authors.initials: B
authors.lastname: Lv
authors.affiliation: Department of Pathology, The Affiliated Women's Hospital, School of Medicine, Zhejiang University Hangzhou 310003, PR China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000232:Adenofibroma / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001706:Biopsy; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007044:Hysterectomy; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D058994:Salpingectomy; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects*; D013629:Tamoxifen / Q000009:adverse effects*; D016896:Treatment Outcome; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery
chemical_list: D018931:Antineoplastic Agents, Hormonal; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen
keywords: Adenofibroma; endometriosis; endometrium; ovary; tamoxifen
references.citation: Invest New Drugs. 1999;17(3):285-311
references.pmid: 10665480
references.citation: Int J Gynecol Cancer. 2009 Dec;19(9):1521-3
references.pmid: 19955929
references.citation: Gynecol Oncol. 2002 Nov;87(2):231-4
references.pmid: 12477460
references.citation: Eur J Gynaecol Oncol. 2003;24(3-4):258-68
references.pmid: 12807236
references.citation: Hum Pathol. 2003 Sep;34(9):939-43
references.pmid: 14562291
references.citation: Gynecol Oncol. 2004 Aug;94(2):256-66
references.pmid: 15297160
references.citation: Eur J Gynaecol Oncol. 1994;15(5):393-5
references.pmid: 7828611
references.citation: Int J Gynecol Pathol. 1996 Apr;15(2):152-7
references.pmid: 8786205
references.citation: Eur J Gynaecol Oncol. 1997;18(6):457-60
references.pmid: 9443009
references.citation: Gynecol Oncol. 1999 May;73(2):305-11
references.pmid: 10329051
references.citation: Am J Obstet Gynecol. 2005 Apr;192(4):1230-7; discussion 1237-9
references.pmid: 15846210
references.citation: Hum Reprod. 2005 Jun;20(6):1511-5
references.pmid: 15845599
references.citation: Jpn J Clin Oncol. 2005 Oct;35(10):607-11
references.pmid: 16254040
references.citation: Reprod Biomed Online. 2008 Jul;17(1):20-6
references.pmid: 18616885
references.citation: Gynecol Obstet Invest. 2008;66(3):209-13
references.pmid: 18645252
references.citation: Am J Surg Pathol. 2009 Feb;33(2):278-88
references.pmid: 18941402
references.citation: Int J Gynecol Pathol. 2000 Jul;19(3):276-9
references.pmid: 10907178