title: Differential pulse voltammetric determination of nanomolar concentrations of antiviral drug acyclovir at polymer film modified glassy carbon electrode.
abstract: An electrochemical sensor for the sensitive detection of acyclovir was developed by the electropolymerization of Eriochrome black T at a pretreated glassy carbon electrode. The surface morphology of the modified electrode was characterized by field emission scanning electron microscopy. Under the optimized conditions, a significant electrochemical improvement was observed toward the electrooxidation of acyclovir on the modified electrode surface relative to the unmodified electrode. The detection limit of 12 nM and two linear calibration ranges of 0.03-0.3 μM and 0.3-1.5 μM were obtained for acyclovir determination using a differential pulse voltammetric method in acetate buffer (0.1 M, pH 4.0). Real sample studies were carried out in human blood serum and pharmaceutical formulations, which offered good recovery (98-102%). The electrode showed excellent reproducibility, selectivity and antifouling effects.
authors.affiliation: Department of Chemistry, Razi University, 67346 Kermanshah, Iran.
authors.forename: Parisa S
authors.initials: PS
authors.lastname: Dorraji
authors.affiliation: Department of Chemistry, Razi University, 67346 Kermanshah, Iran. Electronic address: fjalali@razi.ac.ir.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Jalali
mesh_terms: D000212:Acyclovir / Q000032:analysis* / Q000097:blood; D000998:Antiviral Agents / Q000032:analysis* / Q000097:blood; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques; D004566:Electrodes; D005898:Glass / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D013607:Tablets / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D011108:Polymers; D013607:Tablets; D002244:Carbon; D000212:Acyclovir
keywords: Acyclovir; Differential pulse voltammetry; Glassy carbon electrode; Poly-eriochrome black T