title: Are biologics useful for nail psoriasis?
abstract: Apart from involving skin, psoriasis can compromise the nails and adjacent structures. Even though there are multiple therapeutic alternatives, there is great interest in biological therapy, but no consensus on its role exists. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified two systematic reviews including three randomized trials. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded it is not clear whether biological therapy is superior to placebo in the treatment of nail psoriasis because the certainty of the evidence is very low.
authors.affiliation: Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile, Lira 63, Santiago Centro, Chile. Email: rominaandino@gmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Antúnez-Lay
authors.affiliation: Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
authors.forename: Jorge
authors.initials: J
authors.lastname: Cabrolier
authors.affiliation: Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile; Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Romina
authors.initials: R
authors.lastname: Andino-Navarrete
mesh_terms: D001688:Biological Products / Q000627:therapeutic use*; D016208:Databases, Factual; D003879:Dermatologic Agents / Q000627:therapeutic use; D006801:Humans; D009260:Nail Diseases / Q000188:drug therapy* / Q000473:pathology; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D016032:Randomized Controlled Trials as Topic
chemical_list: D001688:Biological Products; D003879:Dermatologic Agents