title: I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosis.
abstract: Evidence demonstrating that regular ingestion of coffee has salutary effects on patients with chronic liver disease is accumulating rapidly. Specifically, it appears that coffee ingestion can slow the progression of liver fibrosis, preventing cirrhosis and hepatocellular carcinoma (HCC). This should excite clinicians and scientists alike, since these observations, if true, would create effective, testable hypotheses that should lead to improved understanding on fibrosis pathogenesis and thus may generate novel pharmacologic treatments of patients with chronic liver disease. This review is designed to examine the relevant clinical and epidemiological data in critical fashion and to examine the putative pharmacological effects of coffee relevant to the pathogenesis of liver fibrosis and cirrhosis. We hope that this will inspire relevant critical analyses, especially among "coffee skeptics". Of note, one major assumption made by this review is that the bulk of the effects of coffee consumption are mediated by caffeine, rather than by other chemical constituents of coffee. Our rationales for this assumption are threefold: first, caffeine's effects on adenosinergic signaling provide testable hypotheses; second, although there are  myriad chemical constituents of coffee, they are present in very low concentrations, and perhaps more importantly, vary greatly between coffee products and production methods (it is important to note that we do not dismiss the "botanical" hypothesis here; rather, we do not emphasize it at present due to the limitations of the studies examined); lastly, some (but not all) observational studies have examined both coffee and non-coffee caffeine consumption and found consistent effects, and when examined, no benefit to decaffeinated coffee has been observed. Further, in the interval since we examined this phenomenon last, further evidence has accumulated supporting caffeine as the effector molecule for coffee's salutary effects.
authors.affiliation: Toronto Western Hospital Liver Center, Toronto, ON, M5G 2M9, Canada.
authors.forename: Jordan J
authors.initials: JJ
authors.lastname: Feld
authors.affiliation: Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Élise G
authors.initials: ÉG
authors.lastname: Lavoie
authors.affiliation: Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Michel
authors.initials: M
authors.lastname: Fausther
authors.affiliation: Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Dranoff
keywords: adenosine receptor; cirrhosis; coffee; liver fibrosis
references.citation: Ann Epidemiol. 1999 Jul;9(5):325-31
references.pmid: 10976859
references.citation: Hepatology. 2014 Aug;60(2):464-7
references.pmid: 24464631
references.citation: Toxicology. 2013 Jul 5;309:100-6
references.pmid: 23692951
references.citation: Gastroenterology. 2011 Jun;140(7):1961-9
references.pmid: 21376050
references.citation: Inflammation. 2008 Dec;31(6):408-13
references.pmid: 19009339
references.citation: Int J Oncol. 2008 Aug;33(2):287-95
references.pmid: 18636149
references.citation: Br J Pharmacol. 2006 Aug;148(8):1144-55
references.pmid: 16783407
references.citation: Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G249-58
references.pmid: 19556359
references.citation: Hepatology. 2009 Jan;49(1):185-94
references.pmid: 18844235
references.citation: Transplantation. 2012 Nov 15;94(9):894-902
references.pmid: 23073466
references.citation: N Engl J Med. 2012 Aug 9;367(6):576; author reply 576-7
references.pmid: 22873546
references.citation: Pharmacol Rev. 2011 Mar;63(1):1-34
references.pmid: 21303899
references.citation: Gastroenterology. 2007 May;132(5):1740-5
references.pmid: 17484871
references.citation: Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G395-401
references.pmid: 17053161
references.citation: Hepatology. 2012 Feb;55(2):429-36
references.pmid: 21987293
references.citation: Am J Epidemiol. 1997 Dec 15;146(12):1019-24
references.pmid: 9420526
references.citation: Clin Nutr. 2010 Jun;29(3):399-405
references.pmid: 20106566
references.citation: J Hepatol. 2015 Mar;62(3):573-80
references.pmid: 25315650
references.citation: Biochim Biophys Acta. 2011 May;1808(5):1329-39
references.pmid: 20546702
references.citation: Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12012-7
references.pmid: 23812746
references.citation: Eur J Epidemiol. 1993 May;9(3):293-7
references.pmid: 8104822
references.citation: Basic Clin Pharmacol Toxicol. 2012 Nov;111(5):339-47
references.pmid: 22646289
references.citation: Am J Clin Nutr. 2010 Oct;92 (4):960-6
references.pmid: 20826625
references.citation: Clin Gastroenterol Hepatol. 2015 Aug;13(8):1521-31.e3
references.pmid: 25777972
references.citation: Liver Transpl. 2008 Jun;14(6):845-54
references.pmid: 18324658
references.citation: Eur J Epidemiol. 1994 Dec;10(6):657-64
references.pmid: 7672043
references.citation: Hepatology. 2009 Nov;50(5):1360-9
references.pmid: 19676128
references.citation: J Sci Food Agric. 2010 Feb;90(3):450-5
references.pmid: 20355067
references.citation: J Gastroenterol Hepatol. 2013 Dec;28(12):1877-84
references.pmid: 23808892
references.citation: N Engl J Med. 2012 May 17;366(20):1891-904
references.pmid: 22591295
references.citation: J Appl Toxicol. 2013 Sep;33(9):970-9
references.pmid: 22899499
references.citation: Gastroenterology. 2005 Jan;128(1):24-32
references.pmid: 15633120
references.citation: Arch Intern Med. 2009 Dec 14;169(22):2053-63
references.pmid: 20008687
references.citation: Int Immunopharmacol. 2015 Apr;25(2):340-52
references.pmid: 25701503
references.citation: Clin Gastroenterol Hepatol. 2013 Nov;11(11):1413-1421.e1
references.pmid: 23660416
references.citation: Hepatology. 2012 Nov;56(5):2010
references.pmid: 22535683
references.citation: Br J Cancer. 2002 Oct 21;87(9):956-9
references.pmid: 12434283
references.citation: Ann Epidemiol. 1993 Jul;3(4):375-81
references.pmid: 8275213
references.citation: J Clin Epidemiol. 2001 Aug;54(8):823-9
references.pmid: 11470392
references.citation: J Hepatol. 2012 Nov;57(5):1090-6
references.pmid: 22820478
references.citation: Nat Rev Drug Discov. 2013 Apr;12(4):265-86
references.pmid: 23535933
references.citation: Am J Clin Nutr. 1997 Feb;65(2):519-24
references.pmid: 9022539
references.citation: Toxicol Sci. 2013 Jan;131(1):128-38
references.pmid: 22956627
references.citation: Nat Rev Drug Discov. 2008 Sep;7(9):759-70
references.pmid: 18758473
references.citation: Ann Epidemiol. 2001 Oct;11(7):458-65
references.pmid: 11557177
references.citation: Food Funct. 2012 Jan;3(1):30-3
references.pmid: 22130653
references.citation: Liver Int. 2014 Apr;34(4):495-504
references.pmid: 24102757
references.citation: Hepatology. 2015 May;61(5):1672-84
references.pmid: 25557829
references.citation: J Anal Toxicol. 2003 Oct;27(7):520-2
references.pmid: 14607010
references.citation: Int J Epidemiol. 1998 Jun;27(3):438-43
references.pmid: 9698132
references.citation: J Epidemiol. 2012;22(2):160-6
references.pmid: 22343325
references.citation: Dig Liver Dis. 2013 Jun;45(6):499-504
references.pmid: 23238034
references.citation: Cell Mol Life Sci. 2007 Aug;64(16):2153-69
references.pmid: 17514358
references.citation: Hepatology. 2010 Jan;51(1):201-9
references.pmid: 20034049
references.citation: Hepatol Int. 2011 Sep;5(3):857-63
references.pmid: 21484136
references.citation: J Anal Toxicol. 2008 Oct;32(8):702-4
references.pmid: 19007524
references.citation: ScientificWorldJournal. 2011 Feb 03;11:320-39
references.pmid: 21298223
references.citation: Cancer Sci. 2007 Feb;98(2):214-8
references.pmid: 17233838
references.citation: Br J Nutr. 2008 Nov;100(5):1046-53
references.pmid: 18315891
references.citation: J Cell Physiol. 2011 Sep;226(9):2438-47
references.pmid: 21660967