title: [ADENOVIRUSES IN THE ETIOLOGICAL STRUCTURE OF ACUTE RESPIRATORY VIRAL INFECTION IN MOSCOW IN 2004 - 2014].
abstract: OBJECTIVE
  Study prevalence of adenovirus species and serotypes that had caused acute respiratory viral infection (ARVI) in Moscow in 2004 - 2014.
  
  
  METHODS
  Material from respiratory tract of 4731 patients with ARVI and 663 conditionally healthy children and adults was used. ARVI causative agents were detected by PCR with real-time detection using AmpliSens reagent kits (CRIE, Moscow). Membership of adenoviruses to a certain serotype was determined by sequencing of hexon gene segment. Adenoviruses that had caused ARD in servicemen in 2010 - 2014 were also studied.
  
  
  RESULTS
  ARVI causative agents were detected in 64.6% ill children and 58% of adults. Respiratory-syncytial and rhinoviruses prevailed in children, influenza A virus--in adults. Adenoviruses were detected in 6.9% of ill children and 2.9% of adults during the whole year, with a rise in October-December. B and C species occurred at an equal frequency, E species was found less often. Serotypes 3 and 2 prevailed in 34% and 21% of cases of adenovirus mono-infection, respectively, serotypes 7, 6 and 4 occurred less often. 4 out of 5 outbreaks of adenovirus infection in servicemen were caused by serotype 7. Adenoviruses were absent in the group of healthy adults, in conditionally healthy children were detected in 0.4% of cases and were attributed to serotypes 1 and 2.
  
  
  CONCLUSIONS
  Etiological structure of ARVI was studied for the last decade. Adenovirus infection ranked 5th in children and 7th in adults. 9 serotypes of 3 species of respiratory adenoviruses were identified. Varying prevalence of species and serotypes depending in season, clinical diagnosis and patient age was demonstrated.
authors.forename: S B
authors.initials: SB
authors.lastname: Yatsyshina
authors.forename: M R
authors.initials: MR
authors.lastname: Ageeva
authors.forename: N S
authors.initials: NS
authors.lastname: Vorobieva
authors.forename: A V
authors.initials: AV
authors.lastname: Valdokhina
authors.forename: M A
authors.initials: MA
authors.lastname: Elkina
authors.forename: A V
authors.initials: AV
authors.lastname: Gorelov
authors.forename: V V
authors.initials: VV
authors.lastname: Maleev
authors.forename: V I
authors.initials: VI
authors.lastname: Pokrovsky
mesh_terms: D000256:Adenoviridae / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D012426:Russia