title: Naloxone injections into CA3 disrupt pattern completion associated with relapse from cocaine seeking.
abstract: The goal of the present research was to assess the degree to which a pattern completion process operates in cue-induced relapse to cocaine-seeking behavior. Using a novel cue-preference version of the place preference task, rats were administered cocaine or saline, which resulted in a preference for the cocaine-paired cues. After 21 days of abstinence and prior to the preference test, for one group, PBS or naloxone was injected into the CA3 subregion of the hippocampus and for a second group, saline or naloxone was injected systemically. The results indicated that infusions of naloxone into CA3 or systemic injections produced a marked disruption for one and two cues, but had minimal disruptive effect for three or four cues, suggesting that naloxone injections disrupt CA3 function and trigger a deficit in a pattern completion process. Thus, it appears that cue-based activation of the dorsal CA3 might be a critical trigger via a pattern completion process. Based on additional analyses it appears that there is a disruption primarily for object touches for one cue naloxone injections into the CA3 or systemic injections, but no effect on time (spatial context). © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Psychology, University of Utah, Utah.
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Kesner
authors.affiliation: Department of Psychology, University of Utah, Utah.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Kirk
authors.affiliation: Department of Psychology, University of Utah, Utah.
authors.forename: Jascha K
authors.initials: JK
authors.lastname: Clark
authors.affiliation: Department of Psychology, University of Utah, Utah.
authors.forename: Angela
authors.initials: A
authors.lastname: Moore
authors.affiliation: Department of Pharmacology and Toxicology, University of Utah, Utah.
authors.forename: Kristen
authors.initials: K
authors.lastname: Keefe
mesh_terms: D000818:Animals; D056654:CA3 Region, Hippocampal / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D002491:Central Nervous System Agents / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000503:physiopathology; D003216:Conditioning, Operant; D003463:Cues; D004195:Disease Models, Animal; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D058999:Drug-Seeking Behavior / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D020318:Rats, Long-Evans; D012008:Recurrence; D013037:Spatial Behavior
chemical_list: D002491:Central Nervous System Agents; D018765:Dopamine Uptake Inhibitors; D009270:Naloxone; D003042:Cocaine
keywords: CA3; cocaine-seeking; hippocampus; naloxone; relapse
references.citation: Behav Neurosci. 2007 Aug;121(4):742-50
references.pmid: 17663599
references.citation: Eur J Neurosci. 2013 Oct;38(7):3018-26
references.pmid: 23815783
references.citation: Neuropsychopharmacology. 2010 Jan;35(1):217-38
references.pmid: 19710631
references.citation: J Neurosci Methods. 1980 Dec;3(2):129-49
references.pmid: 6110810
references.citation: Philos Trans R Soc Lond B Biol Sci. 1971 Jul 1;262(841):23-81
references.pmid: 4399412
references.citation: Prog Neurobiol. 2006 May;79(1):1-48
references.pmid: 16781044
references.citation: Int J Neuropsychopharmacol. 2008 Feb;11(1):103-9
references.pmid: 17335644
references.citation: Neuroscience. 2010 Dec 15;171(3):830-9
references.pmid: 20870011
references.citation: Hippocampus. 1996;6(6):601-20
references.pmid: 9034849
references.citation: Hippocampus. 2010 Apr;20(4):550-7
references.pmid: 19650123
references.citation: J Neurophysiol. 2002 Feb;87(2):669-78
references.pmid: 11826036
references.citation: Biol Psychiatry. 2007 Apr 15;61(8):979-89
references.pmid: 17098214
references.citation: J Consult Clin Psychol. 1996 Oct;64(5):1044-53
references.pmid: 8916634
references.citation: Addict Behav. 2001 Mar-Apr;26(2):167-80
references.pmid: 11316375
references.citation: Neurobiol Learn Mem. 2007 May;87(4):688-92
references.pmid: 17337218
references.citation: Neuropsychopharmacology. 2005 Feb;30(2):296-309
references.pmid: 15483559
references.citation: Science. 2005 Jun 17;308(5729):1792-4
references.pmid: 15961670
references.citation: Neuropsychopharmacology. 2002 Sep;27(3):391-9
references.pmid: 12225696
references.citation: Drug Discov Today Dis Models. 2008 Winter;5(4):251-258
references.pmid: 20016771
references.citation: Hippocampus. 2005;15(6):808-14
references.pmid: 16010664