title: Unsuspected Intrinsic Property of Melanin to Dissociate Water Can Be Used for the Treatment of CNS Diseases.
abstract: Retinal adhesion mechanisms in mammals are quite complex and multifactorial in nature. To date, these mechanisms are incompletely understood due to a variety of chemical, physical, and physiological forces impinging upon retinal tissue: retinal pigment epithelium, nearby tissues as sclera and vitreous, the subretinal space, and the highly complex interphotoreceptor matrix that fills subretinal space. The adhesion of the retina to the choroid, rather than anatomical, is a dynamic process, as the retina detaches a few minutes after life ceases. The adhesion mechanisms described in the literature, such as intraocular pressure and the oncotic pressure of the choroid that seems to push the retina towards the choroid, the delicate anatomical relationships between the rod and cone photoreceptors, the retinal pigment epithelium, the existence of a complex material called interphotoreceptor matrix, as well as other metabolic and structural factors, still cannot explain the remarkable features observed in the adhesion mechanisms between the photoreceptor layer and retinal pigment epithelium cells. The unexpected intrinsic property of melanin to absorb light energy and transform it into chemically based free energy can explain normal adhesion of the sensory retina to the pigment epithelium. In this article, we explore and highlight this explanation, which states that it is definitely able to provide a new treatment avenue against devastating neurodegenerative properties.
authors.forename: Arturo Solís
authors.initials: AS
authors.lastname: Herrera
authors.forename: María
authors.initials: M
authors.lastname: del Carmen Arias Esparza
authors.forename: Paola Eugenia
authors.initials: PE
authors.lastname: Solís Arias
authors.forename: Marco
authors.initials: M
authors.lastname: Ávila-Rodriguez
authors.forename: George Emilio
authors.initials: GE
authors.lastname: Barreto
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Sergey Olegovich
authors.initials: SO
authors.lastname: Bachurin
authors.affiliation: "GALLY" International Biomedical Research Consulting LLC, San Antonio, TX 78229, USA. aliev03@gmail.com.
authors.forename: Gjumrakch
authors.initials: G
authors.lastname: Aliev
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008543:Melanins / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use*; D012160:Retina / Q000187:drug effects / Q000378:metabolism*; D016896:Treatment Outcome; D014867:Water / Q000378:metabolism*
chemical_list: D008543:Melanins; D014867:Water