title: Prostate Cancer: PI-RADS Version 2 Helps Preoperatively Predict Clinically Significant Cancers.
abstract: Purpose To retrospectively analyze whether Prostate Imaging Reporting and Data System (PI-RADS) version 2 is helpful for the detection of clinically significant prostate cancer. Materials and Methods Institutional review board approved this retrospective study. A total of 425 patients with prostate cancer who had undergone magnetic resonance (MR) imaging and radical prostatectomy were included. Preoperative parameters such as prostate-specific antigen, biopsy Gleason score, greatest percentage of the core, percentage of the positive core number, and score at PI-RADS version 2 with MR imaging were investigated. Two independent readers performed PI-RADS scoring. Clinically significant prostate cancer was defined as follows: (a) Gleason score of 7 or greater, (b) tumor volume of 0.5 cm(3) or greater, or a (c) positive extracapsular extension or seminal vesicle invasion. The reference standard was based on review of surgical specimen. Logistic regression was conducted to determine which parameters are associated with the presence of clinically significant cancer. Interreader agreement (ie, score ≥4 or not) was investigated by using κ statistics. Results At univariate analysis, all of the preoperative parameters were significant for clinically significant prostate cancer (P < .05). However, multivariate analysis revealed that PI-RADS score was the only significant parameter for both readers (reader 1: odds ratio = 28.170, P = .002; reader 2: odds ratio = 5.474, P = .007). The interreader agreement was excellent for PI-RADS score of 4 or greater (weighted κ = 0.801; 95% confidence interval: 0.737, 0.865). Conclusion The use of PI-RADS version 2 may help preoperatively diagnose clinically significant prostate cancer. (©) RSNA, 2016.
authors.affiliation: From the Department of Radiology and Research Institute of Radiological Science (S.Y.P., D.C.J., Y.T.O.), Department of Pathology (N.H.C.), Department of Urology (Y.D.C., K.H.R., S.J.H.), and Avison Biomedical Research Center (K.H.), Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Sung Yoon
authors.initials: SY
authors.lastname: Park
authors.affiliation: From the Department of Radiology and Research Institute of Radiological Science (S.Y.P., D.C.J., Y.T.O.), Department of Pathology (N.H.C.), Department of Urology (Y.D.C., K.H.R., S.J.H.), and Avison Biomedical Research Center (K.H.), Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Dae Chul
authors.initials: DC
authors.lastname: Jung
authors.affiliation: From the Department of Radiology and Research Institute of Radiological Science (S.Y.P., D.C.J., Y.T.O.), Department of Pathology (N.H.C.), Department of Urology (Y.D.C., K.H.R., S.J.H.), and Avison Biomedical Research Center (K.H.), Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Young Taik
authors.initials: YT
authors.lastname: Oh
authors.affiliation: From the Department of Radiology and Research Institute of Radiological Science (S.Y.P., D.C.J., Y.T.O.), Department of Pathology (N.H.C.), Department of Urology (Y.D.C., K.H.R., S.J.H.), and Avison Biomedical Research Center (K.H.), Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Nam Hoon
authors.initials: NH
authors.lastname: Cho
authors.affiliation: From the Department of Radiology and Research Institute of Radiological Science (S.Y.P., D.C.J., Y.T.O.), Department of Pathology (N.H.C.), Department of Urology (Y.D.C., K.H.R., S.J.H.), and Avison Biomedical Research Center (K.H.), Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Young Deuk
authors.initials: YD
authors.lastname: Choi
authors.affiliation: From the Department of Radiology and Research Institute of Radiological Science (S.Y.P., D.C.J., Y.T.O.), Department of Pathology (N.H.C.), Department of Urology (Y.D.C., K.H.R., S.J.H.), and Avison Biomedical Research Center (K.H.), Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Koon Ho
authors.initials: KH
authors.lastname: Rha
authors.affiliation: From the Department of Radiology and Research Institute of Radiological Science (S.Y.P., D.C.J., Y.T.O.), Department of Pathology (N.H.C.), Department of Urology (Y.D.C., K.H.R., S.J.H.), and Avison Biomedical Research Center (K.H.), Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Sung Joon
authors.initials: SJ
authors.lastname: Hong
authors.affiliation: From the Department of Radiology and Research Institute of Radiological Science (S.Y.P., D.C.J., Y.T.O.), Department of Pathology (N.H.C.), Department of Urology (Y.D.C., K.H.R., S.J.H.), and Avison Biomedical Research Center (K.H.), Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Kyunghwa
authors.initials: K
authors.lastname: Han
mesh_terms: D000368:Aged; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods*; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D011873:Radiology Information Systems / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity