title: Role of Platelet Parameters on Sudden Sensorineural Hearing Loss: A Case-Control Study in Iran.
abstract: Sudden sensorineural hearing loss (SSNHL) is a common otological disorder characterized by a hearing loss greater than 30 dB over three consecutive frequencies, in less than 72 hours. It has been established that platelet parameters, such as mean platelet volume, are associated with ischemic heart events, whose clinical manifestations are similar to those of SSNHL. Hence, we aimed to determine if the platelet count, mean platelet volume and platelet distribution width are related to the occurrence and severity of sudden sensorineural hearing loss. A case-control prospective study was conducted in a teaching hospital in Iran. One hundred-eight patients with SSNHL and an equal number of healthy, age- and sex-matched controls were enrolled in the study. Peripheral venous blood samples were collected from the subjects, and the platelet count, mean platelet volume and platelet distribution width were measured with an automated blood cell counter. Analysis of the audiometry and hematological test results using SPSS22 software showed no statistical correlation between the platelet parameters and the occurrence of SSNHL, but correlation coefficients showed a significant correlation between PDW and hearing loss severity in patients group. However, further investigation is required to unequivocally establish the absence of correlation between the platelet parameters and occurrence of SSNHL.
authors.affiliation: Otorhinolaryngology Research Center, Department of Otolaryngology, Head & Neck Surgery, Shahid Sadoughi University Of Medical Sciences, Yazd, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Mirvakili
authors.affiliation: Otorhinolaryngology Research Center, Department of Otolaryngology, Head & Neck Surgery, Shahid Sadoughi University Of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Dadgarnia
authors.affiliation: Otorhinolaryngology Research Center, Department of Otolaryngology, Head & Neck Surgery, Shahid Sadoughi University Of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Baradaranfar
authors.affiliation: Otorhinolaryngology Research Center, Department of Otolaryngology, Head & Neck Surgery, Shahid Sadoughi University Of Medical Sciences, Yazd, Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Atighechi
authors.affiliation: Otorhinolaryngology Research Center, Department of Otolaryngology, Head & Neck Surgery, Shahid Sadoughi University Of Medical Sciences, Yazd, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Zand
authors.affiliation: Otorhinolaryngology Research Center, Department of Otolaryngology, Head & Neck Surgery, Shahid Sadoughi University Of Medical Sciences, Yazd, Iran.
authors.forename: Abdollah
authors.initials: A
authors.lastname: Ansari
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000097:blood*; D006801:Humans; D007492:Iran; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D012044:Regression Analysis
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