title: Translating insights of AR signaling from mouse models.
abstract: Androgen receptor (AR) signaling plays a critical role in the physiology of the prostate and thus the biology of prostate cancer. Agents targeting the AR pathway have been the mainstay of treatment for patients with locally advanced and metastatic prostate cancer. In this review we will cover the role of androgen signaling in prostate cancer mouse models with an emphasis on how tumorigenic molecular alterations impact response to AR pathway inhibition and downstream AR target gene expression. Both of these concepts have meaningful implications for the management of patients with prostate cancer.
authors.affiliation: Department of Surgery, Division of Urology, Memorial Sloan-Kettering Cancer Center, New York, USA.
authors.forename: Brett S
authors.initials: BS
authors.lastname: Carver
keywords: Mouse models; androgen receptor (AR); prostate cancer
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