title: [DIAGNOSTIC MARKERS FOR CHRONIC PANCREATITIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH DIFFERENT PHENOTYPE].
abstract: The purpose--to study the relationships between levels of apelin, elastase-1 and tumor necrosis factor-α (TNF-α) in patients with chronic pancreatitis (CP), type 2 diabetes mellitus (T2DM) and with combined course of its with a different phenotype.
  
  
  METHODS
  The investigation involved of 114 patients with CP, type 2 diabetes mellitus and with combined course of its with a different phenotype. The control group consisted of 20 healthy individuals.
  
  
  RESULTS
  It was found that patients with combined course of CP and type 2 diabetes with overweight had significantly higher hyperapelinemia and hyper-TNF-α-emia (p < 0.05). Patients of all study groups revealed a close correlation between apelin and TNF-α (p < 0.05), a significant correlation between apelin and elastase-1 (p < 0.05). As a result of analysis of variance identified significant contribution of study diseases and different phenotypes in levels of apelin, TNF-α and elastase-1.
  
  
  CONCLUSIONS
  The results of the study suggest that the levels of apelin, TNF-α and elastase-1 are important diagnostic markers of CP in patients with type 2 diabetes mellitus.
authors.forename: L V
authors.initials: LV
authors.lastname: Zhuravlyova
authors.lastname: Shekhovtsova Y A
mesh_terms: D000073861:Apelin; D015415:Biomarkers / Q000097:blood; D048909:Diabetes Complications / Q000097:blood / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood*; D050500:Pancreatitis, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis; D010641:Phenotype; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; D014409:Tumor Necrosis Factor-alpha; D010196:Pancreatic Elastase