title: Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy.
abstract: The COQ2 gene encodes an essential enzyme for biogenesis, coenzyme Q10 (CoQ10). Recessive mutations in this gene have recently been identified in families with multiple system atrophy (MSA). Moreover, specific heterozygous variants in the COQ2 gene have also been reported to confer susceptibility to sporadic MSA in Japanese cohorts. These findings have suggested the potential usefulness of CoQ10 as a blood-based biomarker for diagnosing MSA. This study measured serum levels of CoQ10 in 18 patients with MSA, 20 patients with Parkinson's disease and 18 control participants. Although differences in total CoQ10 (i.e., total levels of serum CoQ10 and its reduced form) among the three groups were not significant, total CoQ10 level corrected by serum cholesterol was significantly lower in the MSA group than in the Control group. Our findings suggest that serum CoQ10 can be used as a biomarker in the diagnosis of MSA and to provide supportive evidence for the hypothesis that decreased levels of CoQ10 in brain tissue lead to an increased risk of MSA.
authors.affiliation: Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.|AMED-CREST, Japan Agency for Medical Research and Development Kyoto 602-0841, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kasai
authors.affiliation: Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.|AMED-CREST, Japan Agency for Medical Research and Development Kyoto 602-0841, Japan.|Department of Molecular Pathobiology of Brain Diseases, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Tokuda
authors.affiliation: Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Ohmichi
authors.affiliation: Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Ishii
authors.affiliation: Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.|Department of Zaitaku (Homecare) Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.
authors.forename: Harutsugu
authors.initials: H
authors.lastname: Tatebe
authors.affiliation: North Medical Center, Kyoto Prefectural University of Medicine, Kyoto 629-2261, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakagawa
authors.affiliation: Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Mizuno
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000378:metabolism; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003710:Demography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000097:blood / Q000150:complications / Q000473:pathology*; D010300:Parkinson Disease / Q000150:complications; D012306:Risk; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000235:genetics
chemical_list: D015415:Biomarkers; D014451:Ubiquinone; D002784:Cholesterol; C024989:coenzyme Q10
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