title: Emerging roles of non-coding RNAs in gastric cancer: Pathogenesis and clinical implications.
abstract: Gastric cancer is a leading cause of cancer-related deaths. However, the mechanisms underlying gastric carcinogenesis remain largely unclear. The association of non-coding RNAs (ncRNAs) with cancer has been widely studied during the past decade. In general, ncRNAs have been classified as small ncRNAs, including microRNAs (miRNAs), and long non-coding RNAs (lncRNAs). Emerging evidence shows that miRNAs and lncRNAs play key roles in the formation and progression of many cancers. In this review, we focus on the regulation of miRNAs and lncRNAs in gastric cancer. miRNAs and lncRNAs appear to be involved in gastric tumor growth, invasion, and metastasis and in establishment of the gastric tumor microenvironment through various mechanisms. Furthermore, we also discuss the possibilities of establishing miRNAs and lncRNAs as potential biomarkers and therapeutic targets for gastric cancer. Taken together, we summarize the emerging roles of ncRNAs in gastric cancer development and their possible clinical significance.
authors.affiliation: Shan-Shan Xie, Juan Jin, Xiao Xu, Wei Zhuo, Tian-Hua Zhou, Department of Cell Biology and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Xie
authors.affiliation: Shan-Shan Xie, Juan Jin, Xiao Xu, Wei Zhuo, Tian-Hua Zhou, Department of Cell Biology and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Jin
authors.affiliation: Shan-Shan Xie, Juan Jin, Xiao Xu, Wei Zhuo, Tian-Hua Zhou, Department of Cell Biology and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xu
authors.affiliation: Shan-Shan Xie, Juan Jin, Xiao Xu, Wei Zhuo, Tian-Hua Zhou, Department of Cell Biology and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhuo
authors.affiliation: Shan-Shan Xie, Juan Jin, Xiao Xu, Wei Zhuo, Tian-Hua Zhou, Department of Cell Biology and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China.
authors.forename: Tian-Hua
authors.initials: TH
authors.lastname: Zhou
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D002465:Cell Movement; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009361:Neoplasm Invasiveness; D010641:Phenotype; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated
keywords: Cancer invasion; Gastric cancer; Long non-coding RNAs; Metastasis; microRNAs
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