title: A highly selective, sensitive and reversible fluorescence chemosensor for Zn(2+) and its cell viability.
abstract: A new imine conjugate Schiff base ligand (H2L) was prepared and evaluated for its sensing properties. H2L detects Zn2+ selectively among the wide range of metal ions. The sensing behavior of H2L was identified by UV-vis, fluorescence and 1H NMR titration. H2L shows fluorescence switch ON with the Zn2+ ion among 18 other metal/heavy metal ions with a detection limit of 1.47 μM. The binding of Zn2+ was confirmed by single crystal X-ray studies, which reveal the formation of binuclear complex (1). The packing diagram of H2L reveals the presence of rare linear C–H⋯C interactions (bond distance 2.79 Å and bond angle 180°) which form 1D-polymeric chains. Furthermore, the cytotoxicity of H2L and 1 has been assessed against MCF-7 and A375 cell lines and both are found to have marginal toxicity.
authors.affiliation: Discipline of Chemistry, Indian Institute of Technology Indore, Simrol, Indore 452020, India.
authors.forename: Anoop Kumar
authors.initials: AK
authors.lastname: Saini
authors.affiliation: Centre for Biosciences and Bio-Medical Engineering, Indian Institute of Technology Indore, Simrol, Indore 452020, India.
authors.forename: Mansi
authors.initials: M
authors.lastname: Srivastava
authors.affiliation: Centre for Biosciences and Bio-Medical Engineering, Indian Institute of Technology Indore, Simrol, Indore 452020, India.
authors.forename: Vinay
authors.initials: V
authors.lastname: Sharma
authors.affiliation: Discipline of Chemistry, Indian Institute of Technology Indore, Simrol, Indore 452020, India.
authors.forename: Veenu
authors.initials: V
authors.lastname: Mishra
authors.affiliation: Discipline of Chemistry, Indian Institute of Technology Indore, Simrol, Indore 452020, India and Centre for Biosciences and Bio-Medical Engineering, Indian Institute of Technology Indore, Simrol, Indore 452020, India and Centre for Material Science and Engineering, Indian Institute of Technology Indore, Simrol, Indore 452020, India. xray@iiti.ac.in.
authors.forename: Shaikh M
authors.initials: SM
authors.lastname: Mobin
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D057230:Limit of Detection; D061986:MCF-7 Cells; D008958:Models, Molecular; D008968:Molecular Conformation; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000032:analysis* / Q000737:chemistry / Q000633:toxicity*
chemical_list: D005456:Fluorescent Dyes; D008024:Ligands; D012545:Schiff Bases; D015032:Zinc