title: Evaluation of peripheral lymphadenopathy with excisional biopsy: six-year experience.
abstract: BACKGROUND
  Lymphadenopathy (LAP) may be the first symptom of many diseases. We aimed to investigate peripheral LAP results taken by excisional biopsy.
  
  
  METHODS
  Histopathological examination of 185 lymph node biopsy specimens were evaluated between January 2009 and April 2015 in Istanbul Private Ekin Pathology Laboratory, retrospectively.
  
  
  RESULTS
  The average age of patients ranged from 1 to 86 was 41.01 ± 20.62 years. 87 of were female, 98 of male. 62 (33.5%) of excisional biopsy materials were benign lesions and 123 (66.5%) of malignant. Benign lesions were consisted of reactive hyperplasia, cat-scratch disease, toxoplasmosis, necrotizing/non-necrotizing granulomatous. Of these patients, 40 had nodes with reactive hyperplasia (15 female/25 male, mean age: 27.35 y), 14 had necrotizing granulomatous disease (9 female/5 male, mean age: 39.86 y), 2 non-necrotizing granulomatous disease (1 female/1 male mean age: 43 y), 4 had cat-scratch disease (1 female/3 male mean age: 54.25 y), 1 toxoplasmosis (26 y, female), 1 Kikuchi disease (25 y, female). In the evaluation of malign lesions; 38 were Hodgkin lymphoma (HL) (20.5%, 17 female/21 male, mean age: 34.89 y) 77 had non-Hodgkin lymphoma (NHL) (41.6%, 37 female/40 male, mean age: 52.26 y), 8 metastasis (4.3%, 5 female/3 male, mean age: 53.5 y). Reactive LAP observed most common in cervical region, NHL in axillary-abdomen-inguinal-mediastinum and HL in the supraclavicular region.
  
  
  CONCLUSIONS
  Excisional biopsy can be applied safely with minimal morbidity and mortality and a gold standard diagnostic method for LAP. Although LAP is mostly related with benign lesions, malignancy should be kept in mind in differential diagnosis.
authors.affiliation: Department of Pediatrics, Faculty of Medical, Bozok University Yozgat, Turkey.
authors.forename: Esra Akyüz
authors.initials: EA
authors.lastname: Özkan
authors.affiliation: Department of Pathology, Haydarpasa Numune Training and Research Hospital Istanbul, Turkey.
authors.forename: Ceren Canbey
authors.initials: CC
authors.lastname: Göret
authors.affiliation: Department of Internal Medicine, Faculty of Medical, Bozok University Yozgat, Turkey.
authors.forename: Zeynep Tuba
authors.initials: ZT
authors.lastname: Özdemir
authors.affiliation: Department of Pathology, Iskenderun State Hospital Hatay, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Yanık
authors.affiliation: Department of General Surgery, Kartal Dr Lütfü Kırdar Training and Research Hospital Istanbul, Turkey.
authors.forename: Nuri Emrah
authors.initials: NE
authors.lastname: Göret
authors.affiliation: Department of Pathology, Faculty of Medical, Atatürk University Erzurum, Turkey.
authors.forename: Meryem
authors.initials: M
authors.lastname: Doğan
authors.affiliation: Department of Family Medicine, Faculty of Medical, Necmettin Erbakan University Konya, Turkey.
authors.forename: Fatma Gökşin
authors.initials: FG
authors.lastname: Cihan
authors.affiliation: Department of Family Medicine, Iskenderun State Hospital Hatay, Turkey.
authors.forename: Ayşe Neslin
authors.initials: AN
authors.lastname: Akkoca
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery*; D008206:Lymphatic Diseases / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014421:Turkey; D055815:Young Adult
keywords: Benign; excisional biopsy; lymphadenopathy; malignant
references.citation: West Afr J Med. 1992 Jan-Mar;11(1):25-8
references.pmid: 1637739
references.citation: Pediatrics. 1982 Apr;69(4):391-6
references.pmid: 7070884
references.citation: Ann Trop Paediatr. 1984 Jun;4(2):83-5
references.pmid: 6083750
references.citation: AJR Am J Roentgenol. 2005 May;184(5):1691-9
references.pmid: 15855141
references.citation: CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
references.pmid: 19474385
references.citation: Iran J Med Sci. 2014 Mar;39(2 Suppl):158-70
references.pmid: 24753638
references.citation: East Afr Med J. 1995 Nov;72(11):703-5
references.pmid: 8904059
references.citation: Am J Dis Child. 1978 Apr;132(4):357-9
references.pmid: 645650
references.citation: Natl Med J India. 2007 Mar-Apr;20(2):78-80
references.pmid: 17802986
references.citation: J Pak Med Assoc. 2011 Mar;61(3):260-3
references.pmid: 21465941
references.citation: Med J Malaysia. 2005 Dec;60(5):590-8
references.pmid: 16515110
references.citation: J Fam Pract. 1988 Oct;27(4):373-6
references.pmid: 3049914
references.citation: Swiss Med Wkly. 2010 Feb 20;140(7-8):98-104
references.pmid: 20069473
references.citation: Am Surg. 1985 Oct;51(10):587-90
references.pmid: 4051335
references.citation: J Pak Med Assoc. 2006 Sep;56(9):405-8
references.pmid: 17091753
references.citation: Am Fam Physician. 1998 Oct 15;58(6):1313-20
references.pmid: 9803196
references.citation: Am Fam Physician. 2002 Dec 1;66(11):2103-10
references.pmid: 12484692
references.citation: Asian Pac J Cancer Prev. 2013;14(7):4359-63
references.pmid: 23992003
references.citation: Saudi Med J. 2002 Mar;23(3):282-6
references.pmid: 11938416
references.citation: Pediatr Surg Int. 2003 Jun;19(4):240-4
references.pmid: 12700919
references.citation: Pediatr Clin North Am. 2002 Oct;49(5):1009-25
references.pmid: 12430623
references.citation: Br J Cancer. 2003 Feb 10;88(3):354-61
references.pmid: 12569376
references.citation: JAMA. 1984 Sep 14;252(10):1321-6
references.pmid: 6471252
references.citation: N Engl J Med. 1979 Nov 29;301(22):1212-22
references.pmid: 388217
references.citation: Rev Infect Dis. 1986 May-Jun;8(3):322-8
references.pmid: 3726392