title: In-hospital free fatty acids levels predict the severity of myocardial ischemia of acute coronary syndrome.
abstract: BACKGROUND
  We aimed to assess whether the levels of FFAs (free fatty acids) in ACS (acute coronary syndrome) patients depend on the extent of myocardial ischemia during the subacute phase of ACS attack.
  
  
  METHODS
  A total of 892 consecutive CAD (coronary artery disease) subjects undergoing coronary angiography were enrolled. The FFAs contents were measured based on enzymatic assay. The relationship between FFAs and Gensini score and ACS susceptibility was assessed.
  
  
  RESULTS
  In the overall population, the upper FFAs quartile was accompanied with higher ischemia parameters and increased occurrence of ACS and STEMI (ST-segment elevation myocardial infarction) (P < 0.05). The FFAs concentrations were approximately 1.5-fold higher in ACS than in stable CAD patients, roughly 1.3-fold higher in STEMI than non-STEMI ACS patients and probably 1.3-fold higher in non-STEMI ACS than in stable CAD patients. After adjusted for traditional cardiovascular risk factors, the FFAs level remained a risk factor for a higher Gensini score with more than 40 (P < 0.001) and prevalent ACS (P < 0.001). After adjusted for traditional risk factors, FFAs levels after natural logarithm transformation were associated with hs-CRP and WBC counts in ACS patients. A multiplicative interaction was found between hs-CRP, WBC counts and FFAs in incident ACS and higher Gensini score (P < 0.001).
  
  
  CONCLUSIONS
  Higher in-hospital levels of FFAs persist and may reflect the severity of ischemia and necrosis during the subacute phase of ACS attack.
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Donghu Road 169#, Wuhan, 430071, Hubei, PR China. mapei2010@126.com.
authors.forename: Pei
authors.initials: P
authors.lastname: Ma
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Donghu Road 169#, Wuhan, 430071, Hubei, PR China. medicalhl@126.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Han
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Donghu Road 169#, Wuhan, 430071, Hubei, PR China. 893999609@qq.com.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Lv
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Donghu Road 169#, Wuhan, 430071, Hubei, PR China. weiwei000720@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Donghu Road 169#, Wuhan, 430071, Hubei, PR China. hhn_2296@sina.com.
authors.forename: Hanning
authors.initials: H
authors.lastname: Hu
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Donghu Road 169#, Wuhan, 430071, Hubei, PR China. jian_1999@yahoo.com.
authors.forename: Jiancheng
authors.initials: J
authors.lastname: Tu
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Donghu Road 169#, Wuhan, 430071, Hubei, PR China. zhouxjyk@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Donghu Road 169#, Wuhan, 430071, Hubei, PR China. smliu@whu.edu.cn.
authors.forename: Song-Mei
authors.initials: SM
authors.lastname: Liu
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging; D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000097:blood* / Q000000981:diagnostic imaging; D000789:Angina, Unstable / Q000097:blood* / Q000000981:diagnostic imaging; D002097:C-Reactive Protein / Q000378:metabolism; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging; D017202:Myocardial Ischemia / Q000097:blood / Q000000981:diagnostic imaging; D012720:Severity of Illness Index
chemical_list: D005230:Fatty Acids, Nonesterified; D002097:C-Reactive Protein
references.citation: Catheter Cardiovasc Interv. 2013 Jul 1;82(1):E1-27
references.pmid: 23299937
references.citation: PLoS One. 2013;8(1):e55869
references.pmid: 23383292
references.citation: Clin Chim Acta. 2013 Jan 16;415:81-7
references.pmid: 23063962
references.citation: J Am Coll Cardiol. 2012 Oct 16;60(16):1581-98
references.pmid: 22958960
references.citation: Clin Chem Lab Med. 2008;46(4):429-34
references.pmid: 18605928
references.citation: Am J Respir Crit Care Med. 2012 May 1;185(9):924-32
references.pmid: 22205565
references.citation: J Mol Endocrinol. 2011 Dec;47(3):315-26
references.pmid: 21994216
references.citation: Int J Cardiol. 2011 Oct 20;152(2):218-24
references.pmid: 20692055
references.citation: Am Heart J. 2011 Aug;162(2):276-282.e1
references.pmid: 21835288
references.citation: Heart. 2010 Dec;96(23):1883-4
references.pmid: 20962339
references.citation: Int J Cardiol. 2013 Oct 15;168(6):5126-34
references.pmid: 23978367
references.citation: Circ Res. 2014 Feb 14;114(4):594-5
references.pmid: 24526672
references.citation: BMC Med. 2014;12:47
references.pmid: 24642015
references.citation: J Hypertens. 2015 Apr;33(4):860-7
references.pmid: 25915891
references.citation: Eur Heart J. 2007 Nov;28(22):2699-700
references.pmid: 17933757
references.citation: QJM. 2006 Oct;99(10):701-9
references.pmid: 16935924
references.citation: Cytokine. 1999 May;11(5):334-46
references.pmid: 10328873
references.citation: N Engl J Med. 1999 Jan 14;340(2):115-26
references.pmid: 9887164
references.citation: Am J Cardiol. 2012 Jul 15;110(2):212-6
references.pmid: 22503582
references.citation: Am J Cardiol. 1983 Feb;51(3):606
references.pmid: 6823874
references.citation: Lancet. 1968 Apr 6;1(7545):710-4
references.pmid: 4170959
references.citation: Lancet. 1966 Jul 16;2(7455):122-7
references.pmid: 4161376
references.citation: J Clin Endocrinol Metab. 2003 Jul;88(7):3005-10
references.pmid: 12843134
references.citation: Circulation. 2003 Jan 28;107(3):391-7
references.pmid: 12551861
references.citation: Lancet. 1983 Aug 20;2(8347):419-22
references.pmid: 6135910