title: Diagnostic value of the plasmatic ADM level for early ectopic pregnancy.
abstract: OBJECTIVE
  To analyze the plasmatic ADM level in early pregnancy and to investigate the diagnostic value of ADM in early ectopic pregnancy (EP).
  
  
  METHODS
  70 patients with EP who had menopause for 5~8 weeks were included as study group, while 155 women with normal intrauterine pregnancy were also included as control group. The correlation between ADM level and menopause weeks was statistically analyzed and ROC curve was used to identify the diagnostic value of ADM.
  
  
  RESULTS
  (1) In 155 cases of normal intrauterine pregnancy, the plasmatic ADM level was increased with menopause weeks in linear relationship, and the correlation coefficient (R) was 0.991 (P<0.05). In 70 patients with EP, no significant increase was found with menopause weeks and no linear relationship can be found between ADM level and menopause weeks in EP group. The correlation coefficient (R) was 0.744 (P>0.05). (2) The multiple of median of plasmatic ADM level in EP group of menopause for 8 weeks was obviously lower than the intrauterine control group (P<0.01). (3) ROC curve was used to analyze the cut-off value of ADM level in the diagnosis of EP, and the area under the ROC curve was 0.523 (P>0.05) regardless of menopause weeks, however, the area under the ROC curve was 0.702 (P<0.05) at 8 weeks after menopause with sensitivity of 53.50% and specificity of 85.00%.
  
  
  CONCLUSIONS
  Different from normal intrauterine pregnancy, plasmatic ADM level in early EP was relatively lower and no significant increase was found with menopause weeks; further studies are still needed for plasmatic ADM level as an indicator in the early diagnosis of EP.
authors.affiliation: Jiangwan Hospital of Shanghai Hongkou District Shanghai, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yan
authors.affiliation: The International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiaotong University Shanghai, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Lu
authors.affiliation: The International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiaotong University Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tao
authors.affiliation: The International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiaotong University Shanghai, China.
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Wang
authors.affiliation: Jiangwan Hospital of Shanghai Hongkou District Shanghai, China.
authors.forename: Wen-Xia
authors.initials: WX
authors.lastname: Zhao
mesh_terms: D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D042241:Early Diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood* / Q000175:diagnosis*; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: C507862:ADM protein, human; D015415:Biomarkers; D053607:Adrenomedullin
keywords: Adrenomedullin; early pregnancy; ectopic pregnancy
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