title: Oral hyaluronan relieves knee pain: a review.
abstract: Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief of synovial effusion or inflammation, and improvement of muscular knee strength. The mechanism by which HA exerts its effects in the living body, specifically receptor binding in the intestinal epithelia, has gradually been clarified. This review examines the effects of HA upon knee pain as assessed in clinical trials, as well as the mechanism of these effects and the safety of HA.
authors.affiliation: R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan. mariko_oe@kewpie.co.jp.
authors.forename: Mariko
authors.initials: M
authors.lastname: Oe
authors.affiliation: Tokyo Yamate Medical Center, 3-22-1 Hyakunin-cho, Shinjyuku-ku, Tokyo, Japan. tsyktashiro@yahoo.co.jp.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tashiro
authors.affiliation: R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan. hideto_yoshida@kewpie.co.jp.
authors.forename: Hideto
authors.initials: H
authors.lastname: Yoshida
authors.affiliation: R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan. hiroshi_nishiyama@kewpie.co.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishiyama
authors.affiliation: R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan. yasunobu_masuda@kewpie.co.jp.
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Masuda
authors.affiliation: Gate Town Hospital, 1-6-19, Sekimachi-kita, Nerima-ku, Tokyo, Japan. gthsplab@sweet.ocn.ne.jp.
authors.forename: Koh
authors.initials: K
authors.lastname: Maruyama
authors.affiliation: Shiba Palace Clinic, 1-9-10 Hamamatsucho, Minato-ku, Tokyo, Japan. shiba_palace@s-palace-clinic.com.
authors.forename: Takashi
authors.initials: T
authors.lastname: Koikeda
authors.affiliation: SOUKEN Corporation, 1-9-10, Hamamatsu-cho, Minato-ku, Tokyo, Japan. maruya@souken-lab.co.jp.
authors.forename: Reiko
authors.initials: R
authors.lastname: Maruya
authors.affiliation: Department of Life Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan. n-fukui@idaten.c.u-tokyo.ac.jp.
authors.forename: Naoshi
authors.initials: N
authors.lastname: Fukui
mesh_terms: D000284:Administration, Oral; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D020370:Osteoarthritis, Knee / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic
chemical_list: D006820:Hyaluronic Acid
references.citation: Reproduction. 2013 May;145(5):491-504
references.pmid: 23630333
references.citation: Osteoarthritis Cartilage. 2001 May;9(4):371-81
references.pmid: 11399102
references.citation: Clin Exp Rheumatol. 1998 Jul-Aug;16(4):441-9
references.pmid: 9706425
references.citation: J Rheumatol. 1998 Sep;25(9):1813-9
references.pmid: 9733465
references.citation: J Agric Food Chem. 2008 Nov 26;56(22):10582-93
references.pmid: 18959406
references.citation: Osteoarthritis Cartilage. 1997 May;5(3):153-60
references.pmid: 9219678
references.citation: Clin Orthop Relat Res. 1989 Apr;(241):286-99
references.pmid: 2466597
references.citation: J Orthop Res. 2000 Jul;18(4):604-12
references.pmid: 11052497
references.citation: Osteoarthritis Cartilage. 1998 Jan;6(1):1-9
references.pmid: 9616433
references.citation: Clin Orthop Relat Res. 1994 Feb;(299):282-92
references.pmid: 8119031
references.citation: J Rheumatol. 2004 Apr;31(4):775-82
references.pmid: 15088306
references.citation: Arch Histol Cytol. 1998 May;61(2):125-35
references.pmid: 9650887
references.citation: Acta Orthop Scand. 2001 Jun;72(3):299-303
references.pmid: 11480609
references.citation: ScientificWorldJournal. 2012;2012:167928
references.pmid: 23226979
references.citation: J Intern Med. 1997 Jul;242(1):27-33
references.pmid: 9260563
references.citation: J Biol Chem. 2010 Aug 6;285(32):24751-8
references.pmid: 20504769
references.citation: Arthritis Res Ther. 2007;9(1):R1
references.pmid: 17214881
references.citation: J Med Food. 2015 Jan;18(1):95-101
references.pmid: 25415767
references.citation: Exp Ther Med. 2010 Sep;1(5):817-827
references.pmid: 22993606
references.citation: Exp Ther Med. 2012 Oct;4(4):577-580
references.pmid: 23170108
references.citation: J Food Sci. 2014 Jul;79(7):T1469-75
references.pmid: 24894153
references.citation: Biomacromolecules. 2011 Oct 10;12(10):3432-43
references.pmid: 21823600
references.citation: Rheumatology (Oxford). 2001 Feb;40(2):158-69
references.pmid: 11257152
references.citation: Rheumatol Int. 2015 Jan;35(1):43-52
references.pmid: 24899570
references.citation: FASEB J. 1992 Apr;6(7):2397-404
references.pmid: 1563592
references.citation: J Rheumatol. 2006 May;33(5):946-50
references.pmid: 16652425
references.citation: Am Fam Physician. 2000 Aug 1;62(3):565-70, 572
references.pmid: 10950213
references.citation: ScientificWorldJournal. 2014;2014:378024
references.pmid: 25383371
references.citation: Arthritis Rheum. 1967 Aug;10(4):357-76
references.pmid: 6046018
references.citation: Clin Rheumatol. 2001;20(2):98-103
references.pmid: 11346239
references.citation: Biosci Biotechnol Biochem. 2008 Apr;72(4):1111-4
references.pmid: 18391466
references.citation: Nutr J. 2008;7:3
references.pmid: 18208600
references.citation: J Rheumatol Suppl. 1995 Feb;43:155-7
references.pmid: 7752123
references.citation: MMWR Morb Mortal Wkly Rep. 2001 May 4;50(17):334-6
references.pmid: 11465902
references.citation: Genes Nutr. 2014 Sep;9(5):417
references.pmid: 25024048
references.citation: Pathol Biol (Paris). 1974 Oct;22(8):731-6
references.pmid: 4614175
references.citation: Clin Orthop Relat Res. 1994 Jan;(298):296-304
references.pmid: 8118990
references.citation: Osteoarthritis Cartilage. 1997 Jul;5(4):251-60
references.pmid: 9404470