title: Frontiers in microbial 1-butanol and isobutanol production.
abstract: The heavy dependence on petroleum-derived fuel has raised concerns about energy sustainability and climate change, which have prompted researchers to explore fuel production from renewable sources. 1-Butanol and isobutanol are promising biofuels that have favorable properties and can also serve as solvents or chemical feedstocks. Microbial production of these alcohols provides great opportunities to access a wide spectrum of renewable resources. In recent years, research has improved the native 1-butanol production and has engineered isobutanol production in various organisms to explore metabolic diversity and a broad range of substrates. This review focuses on progress in metabolic engineering for the production of these two compounds using various resources.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, USA.
authors.forename: Chang-Ting
authors.initials: CT
authors.lastname: Chen
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, USA UCLA-DOE Institute of Genomics and Proteomics, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, USA liaoj@ucla.edu.
authors.forename: James C
authors.initials: JC
authors.lastname: Liao
mesh_terms: D020001:1-Butanol / Q000378:metabolism*; D056804:Biofuels / Q000382:microbiology; D000440:Butanols / Q000378:metabolism*; D003013:Clostridium / Q000235:genetics* / Q000378:metabolism*; D005285:Fermentation; D060847:Metabolic Engineering
chemical_list: D056804:Biofuels; D000440:Butanols; C040507:isobutyl alcohol; D020001:1-Butanol
keywords: ABE fermentation; butanol; isobutanol; metabolic engineering; synthetic biology