title: [Anticholinergics do not affect the sexual function in women diagnosed with multiple sclerosis].
abstract: OBJECTIVE
  Determine if the initiation of an anticholinergic treatment affects the sexual function in women diagnosed with multiple sclerosis (MS).
  
  
  METHODS
  It was a single-centre prospective open label study on 18 women affected by MS, with a clinical overactive bladder syndrome, and examined before and after anticholinergic treatment. Several variables were studied before and after treatment: the total anticholinergic load (Anticholinergic Drug Scale [ADS]), the Female Sexual Function Index, the Urinary Symptom Profile (USP) and functional status (EDSS, MIF). Quantitative variables were analyzed using Student's test.
  
  
  RESULTS
  Eighteen women with an average age of 48.3 years old (±10.7 years), average EDSS of 4.6 (±1.5) were examined before and after anticholinergic treatment (solifenacin and trospium). Anticholinergic load at baseline was 0.33 (±0.5) and 3.44 (±0.70) after treatment (P<0.0001). The initiation of an anticholinergic treatment allowed a significant improvement on the subscore OAB USP (10.25±4.3 to 6.22±3 P=0.01). No significant impacts of the anticholinergic load on the Female Sexual Function Index (FSFI) score (18.9±10.8 to 21.2±10.8 P=0.06) and sub-items lubrification (3.6±2.2 to 3.7±2.2 P=0.6), pain (3.6±2.5 to 4.2±2.3 P=0.4), desire (3±1.2 to 3±1.5 P=0.7), orgasm (2.7±2.1 to 3±2.4 P=0.4), satisfaction (3.9± to 4±2 p=0.9), arousal (2.9±2 to 3.3±1.8 P=0.8) was evidenced.
  
  
  CONCLUSIONS
  In this limited series of "naive" patients with MS, no impact of anticholinergic therapy on vaginal lubrication or sexual quality was observed.
  
  
  METHODS
  4.
authors.affiliation: Service de neuro-urologie, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France. Electronic address: julie_dimarco@hotmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Di Marco
authors.affiliation: Service de neuro-urologie, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: De Broglie
authors.affiliation: Service de neuro-urologie, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Manceau
authors.affiliation: Service de neuro-urologie, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Weglinski
authors.affiliation: Service de neuro-urologie, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France; GRC01 GREEN groupe de recherche clinique en neuro-urologie, Sorbonne universités UPMC, 75005 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Le Breton
authors.affiliation: Service de neuro-urologie, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France; GRC01 GREEN groupe de recherche clinique en neuro-urologie, Sorbonne universités UPMC, 75005 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Verrollet
authors.affiliation: Service de neuro-urologie, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France; GRC01 GREEN groupe de recherche clinique en neuro-urologie, Sorbonne universités UPMC, 75005 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Amarenco
mesh_terms: D018680:Cholinergic Antagonists / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D011446:Prospective Studies; D019529:Sexuality / Q000187:drug effects*; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D018680:Cholinergic Antagonists
keywords: Anticholinergic; Anticholinergiques; Femmes; Fonction sexuelle; Hyperactivité vésicale; Multiple sclerosis; Overactive bladder; Sclérose en plaques; Sexual function; Women