title: Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents.
abstract: Considerable evidence has suggested that the epigenetic regulation of N-methyl-D-aspartate (NMDA) glutamate receptors plays a crucial role in neuropsychiatric disorders. Previous exploratory studies have been primarily based on evidence from patients and have rarely sampled the general population. This exploratory study examined the relationship of single-nucleotide polymorphism (SNP) variations in the genes encoding the NMDA receptor (i.e., GRIN1, GRIN2A, GRIN2B, GRIN2C, and GRIN2D) with emotion and social behavior in adolescents. For this study, 832 tenth-grade Taiwanese volunteers were recruited, and their scores from the Beck Youth Inventories were used to evaluate their emotional and social impairments. Based on these scores, GRIN1 (rs4880213) was significantly associated with depression and disruptive behavior. In addition, GRIN2B (rs7301328) was significantly associated with disruptive behavior. Because emotional and social impairment greatly influence learning ability, the findings of this study provide important information for clinical treatment and the development of promising prevention and treatment strategies, especially in the area of psychological adjustment.
authors.affiliation: Science Education Center and Graduate Institute of Science Education, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, Taiwan.
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Lee
authors.affiliation: Science Education Center and Graduate Institute of Science Education, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, Taiwan.
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Cho
authors.affiliation: Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University Hospital, No. 1, Section 1, Jen-Ai Road, Taipei 100, Taiwan.
authors.forename: Pei-Jung
authors.initials: PJ
authors.lastname: Lin
authors.affiliation: Department of Pediatrics, Mackay Memorial Hospital, 92 Section 2, Zhongshan N. Road, Taipei 104, Taiwan.
authors.forename: Ting-Chi
authors.initials: TC
authors.lastname: Yeh
authors.affiliation: Science Education Center and Graduate Institute of Science Education, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, Taiwan; Department of Earth Sciences, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, Taiwan.
authors.forename: Chun-Yen
authors.initials: CY
authors.lastname: Chang
authors.affiliation: Science Education Center and Graduate Institute of Science Education, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, Taiwan; Department of Earth Sciences, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, Taiwan; Institute of Marine Environmental Science and Technology, National Taiwan Normal University, 88 Section 4, Ting-Chou Road, Taipei 116, Taiwan.
authors.forename: Ting-Kuang
authors.initials: TK
authors.lastname: Yeh
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D044127:Epigenesis, Genetic; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*; D012919:Social Behavior
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate
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