title: Methods for the integration of multi-omics data: mathematical aspects.
abstract: BACKGROUND
  Methods for the integrative analysis of multi-omics data are required to draw a more complete and accurate picture of the dynamics of molecular systems. The complexity of biological systems, the technological limits, the large number of biological variables and the relatively low number of biological samples make the analysis of multi-omics datasets a non-trivial problem.
  
  
  CONCLUSIONS
  We review the most advanced strategies for integrating multi-omics datasets, focusing on mathematical and methodological aspects.
authors.affiliation: Department of Physics and Astronomy, Universita' di Bologna, Via B. Pichat 6/2, Bologna, 40127, Italy. matteo.bersanelli@studio.unibo.it.|Institute of Biomedical Technologies - CNR, Via Fratelli Cervi 93, Segrate MI, 20090, Italy. matteo.bersanelli@studio.unibo.it.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bersanelli
authors.affiliation: Institute of Biomedical Technologies - CNR, Via Fratelli Cervi 93, Segrate MI, 20090, Italy. ettore.mosca@itb.cnr.it.
authors.forename: Ettore
authors.initials: E
authors.lastname: Mosca
authors.affiliation: Department of Physics and Astronomy, Universita' di Bologna, Via B. Pichat 6/2, Bologna, 40127, Italy. daniel.remondini@unibo.it.
authors.forename: Daniel
authors.initials: D
authors.lastname: Remondini
authors.affiliation: Department of Physics and Astronomy, Universita' di Bologna, Via B. Pichat 6/2, Bologna, 40127, Italy. enrico.giampieri@unibo.it.
authors.forename: Enrico
authors.initials: E
authors.lastname: Giampieri
authors.affiliation: Department of Physics and Astronomy, Universita' di Bologna, Via B. Pichat 6/2, Bologna, 40127, Italy. claudia.sala@studio.unibo.it.
authors.forename: Claudia
authors.initials: C
authors.lastname: Sala
authors.affiliation: Department of Physics and Astronomy, Universita' di Bologna, Via B. Pichat 6/2, Bologna, 40127, Italy. gastone.castellani@unibo.it.
authors.forename: Gastone
authors.initials: G
authors.lastname: Castellani
authors.affiliation: Institute of Biomedical Technologies - CNR, Via Fratelli Cervi 93, Segrate MI, 20090, Italy. luciano.milanesi@itb.cnr.it.
authors.forename: Luciano
authors.initials: L
authors.lastname: Milanesi
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D023281:Genomics / Q000379:methods*; D006801:Humans; D016018:Least-Squares Analysis; D008957:Models, Genetic; D012984:Software
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