title: Aldosterone Production and Signaling Dysregulation in Obesity.
abstract: In the past decades, we have extended the view of aldosterone effects beyond epithelial tissues. New evidence regarding the aldosterone/mineralocorticoid receptor (MR) pathway in active metabolic tissues, including adipose tissue, has confirmed its pathogenic role in systemic inflammation, endothelial dysfunction, insulin resistance, and dyslipidemia. Obesity, a current epidemic worldwide, increases aldosterone production by several adipocyte factors such as leptin but is also associated with local aldosterone production. In addition, obesity can modulate MR activation leading to signaling dysregulation and a pro-inflammatory profile of adipocytes. Current knowledge have deciphered that this phenotypical differences of obesity may be explained, at least in part, by novel non-genomic activation of MR, new inducers of aldosterone synthesis, and probably by several epigenetic modifications. In addition, with the understanding of the complex interplay of obesity, hormones, and receptors, targeted pharmacological therapy is expected and is currently under active research.
authors.affiliation: Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile, Lira 85, 5th Floor, Santiago, 8330074, Chile.|Millenium Institute on Immunology and Immunotherapy IMII, Santiago, Chile.
authors.forename: Andrea
authors.initials: A
authors.lastname: Vecchiola
authors.affiliation: Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile, Lira 85, 5th Floor, Santiago, 8330074, Chile.|Facultad de Ciencia, Universidad San Sebastián, Santiago, Chile.
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Lagos
authors.affiliation: Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile, Lira 85, 5th Floor, Santiago, 8330074, Chile.|Millenium Institute on Immunology and Immunotherapy IMII, Santiago, Chile.
authors.forename: Cristian A
authors.initials: CA
authors.lastname: Carvajal
authors.affiliation: Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile, Lira 85, 5th Floor, Santiago, 8330074, Chile.
authors.forename: Rene
authors.initials: R
authors.lastname: Baudrand
authors.affiliation: Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile, Lira 85, 5th Floor, Santiago, 8330074, Chile. cfardella@med.puc.cl.|Millenium Institute on Immunology and Immunotherapy IMII, Santiago, Chile. cfardella@med.puc.cl.
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Fardella
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D006801:Humans; D009765:Obesity / Q000378:metabolism*; D018161:Receptors, Mineralocorticoid / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018161:Receptors, Mineralocorticoid; D000450:Aldosterone
keywords: Adiponectin; Adipose tissue dysfunction; Aldosterone; Aldosterone synthase; GPR30; Leptin; Metabolic syndrome; Mineralocorticoid receptor; Obesity; Renin-angiotensin-aldosterone system
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