title: CD40 -1C>T polymorphism and the risk of lung cancer in a Chinese population.
abstract: BACKGROUND
  The co-stimulatory molecule CD40 plays an important role in anti-tumor responses by promoting cytotoxic T lymphocyte (CTL) activity and differentiation of helper T cells. Growing evidence suggests that single nucleotide polymorphisms (SNPs) in CD40 are associated with the susceptibility to cancer. This study investigated the association between the CD40 -1C/T SNP (rs1883832) and lung cancer in a Chinese population.
  
  
  METHODS
  We conducted a hospital-based case-control study including 105 lung cancer patients and 109 healthy control subjects. The -1C/T SNP in CD40 was genotyped by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), and its association with lung cancer susceptibility was evaluated.
  
  
  RESULTS
  The distribution of the genotypes of CD40-1C/T was significantly different between lung cancer patients and controls. The frequency of the TT genotype (adjusted P = 0.017; overall risk [OR] = 2.94; 95% confidence interval [CI] = 1.21-7.13) and TT/CT genotype (adjusted P = 0.020; OR = 1.95; 95% CI = 1.11-3.43) were significantly higher in lung cancer patients than that in controls. When the cases were categorized by tumor histology, the TT genotype was associated with a significantly increased risk of squamous cell carcinoma (adjusted OR = 6.53; 95% CI = 1.97-21.61; P = 0.002).
  
  
  CONCLUSIONS
  Our findings suggest that the CD40 -1C/T SNP (rs1883832) is correlated with the susceptibility to lung cancer in Chinese, and the TT genotype may further increase the risk of lung cancer.
authors.affiliation: Department of Immunology, Fourth Military Medical University Xi'an, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Department of Immunology, Fourth Military Medical UniversityXi'an, China; Department of Stomatology, Affiliated Hospital of Academy of Military Medical SciencesBeijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Immunology, Fourth Military Medical University Xi'an, China.
authors.forename: Ziyao
authors.initials: Z
authors.lastname: Fang
authors.affiliation: Department of Immunology, Fourth Military Medical University Xi'an, China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Preventive Medicine and Health Statistics, Fourth Military Medical University Xi'an, China.
authors.forename: Anhui
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University Xi'an, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Department of Immunology, Fourth Military Medical University Xi'an, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D019013:CD40 Antigens / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D019013:CD40 Antigens
keywords: CD40; lung cancer; single nucleotide polymorphism
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