title: The Antagonistic Effect of Selenium on Lead-Induced Inflammatory Factors and Heat Shock Protein mRNA Level in Chicken Cartilage Tissue.
abstract: Selenium (Se) is recognized as a necessary trace mineral in animal diets, including those of birds. Lead (Pb) is a toxic heavy metal and can damage organs in humans and animals. Complex antagonistic interactions between Se and heavy metals have been reported in previous studies. However, little is known regarding the effects of Se on Pb-induced toxicity and the expression of inflammatory factors and heat shock proteins (HSPs) in the cartilage of chickens. In this present study, we fed chickens either with Se or Pb or both Se and Pb supplement and later analyzed the mRNA expressions of inflammatory factors (inducible nitric oxide synthase (iNOS), nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), and cyclooxygenase-2 (COX-2)) and HSPs (Hsp27, Hsp40, Hsp60, Hsp70, and Hsp90). The results showed that Se and Pb influenced the expression of inflammatory factors and HSP genes in the chicken cartilage tissues. Additionally, we also found that antagonistic interaction existed between Se and Pb supplementation. Our findings suggested that Se could exert a antagonistic effect on Pb in chicken cartilage tissues.
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
authors.forename: Shufang
authors.initials: S
authors.lastname: Zheng
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
authors.forename: Huanyu
authors.initials: H
authors.lastname: Song
authors.affiliation: College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
authors.forename: Han
authors.initials: H
authors.lastname: Gao
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
authors.forename: Chunpeng
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China. zhangziwe@sina.com.
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China. jf699@cornell.edu.|Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. jf699@cornell.edu.
authors.forename: Jing
authors.initials: J
authors.lastname: Fu
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000096:biosynthesis*; D002356:Cartilage / Q000378:metabolism* / Q000473:pathology; D002645:Chickens / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D018836:Inflammation Mediators / Q000378:metabolism*; D007854:Lead / Q000633:toxicity*; D012643:Selenium / Q000494:pharmacology*
chemical_list: D030161:Avian Proteins; D006360:Heat-Shock Proteins; D018836:Inflammation Mediators; D007854:Lead; D012643:Selenium
keywords: Chicken cartilage tissues; Heat shock protein; Inflammatory factor; Lead; Selenium