title: Cytopathological diagnosis of gallbladder mass and mural thickening based on imaging findings: A prospective study of 51 cases.
abstract: BACKGROUND
  Image-guided fine-needle aspiration cytology (FNAC) serves as first-line diagnostic modalities for the assessment of mural thickening of the gallbladder (GB).
  
  
  OBJECTIVE
  The main objective of the present study was to correlate the diagnostic accuracy of preoperative image-guided FNAC of the thickened GB wall based on imaging findings to arrive at a final diagnosis in a tertiary care center.
  
  
  METHODS
  Fifty-seven image-guided fine-needle aspirations (FNAs) were performed from mural thickening of the GB over a period of 4 years and the smears prepared were stained with Leishman and Papanicolaou (Pap) stain. Out of 57 cases, 51 were included in the study for which follow-up histopathology was performed.
  
  
  RESULTS
  Out of 51 aspirations, 43 (84.3%) were adequate, 5 (9.8%) were inconclusive, and 3 (5.9%) were inadequate. Among the adequate aspirations, the most common was adenocarcinoma-36 (70.5%). The correlation between confirmatory cytological diagnosis and adequacy was significantly high (P = 0.0001). The overall diagnostic accuracy for adequate aspiration was 95.3%. The common diagnostic pitfalls were necrotic areas, aspiration of reactive hepatocytes adjacent to the GB mass, and mucus islands. No procedural complication was observed in any patient.
  
  
  CONCLUSIONS
  Image-guided FNAC can be used as a safe, rapid, and successful diagnostic procedure with high sensitivity, specifically for supporting and confirming ultrasonography(USG)/computed tomography (CT) diagnosis of GB mass or mural thickening of the wall.
authors.affiliation: Department of Pathology, Command Hospital (CC), Lucknow, Uttar Pradesh, India.
authors.forename: Nikhilesh
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Department of Pathology, Military Hospital, Danapur, Bihar, India.
authors.forename: Paresh
authors.initials: P
authors.lastname: Singhal
authors.affiliation: Department of Pathology, Command Hospital (CC), Lucknow, Uttar Pradesh, India.
authors.forename: Ashwini
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Department of Pathology, Command Hospital (CC), Lucknow, Uttar Pradesh, India.
authors.forename: Majid Ali
authors.initials: MA
authors.lastname: Khan
keywords: Carcinoma of the gallbladder (Ca GB); gallbladder (GB) mass; image-guided fine-needle aspiration cytology (FNAC); mural thickening
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