title: Lack of serum antineuronal antibodies in children with autism.
abstract: OBJECTIVE
  Autism spectrum disorders (ASDs) are a severe group of neurodevelopmental disorders that are characterized by impairment in social communication, and imagination and social interaction. The aetiology of autism is complex, but some studies suggest autoimmunity to the central nervous system in the pathogenesis. The aim of this study is to investigate the positivity of antineuronal antibodies including anti-glutamic acid decarboxylase antibodies (anti-GAD), anti-glutamate receptor (anti-GluR) antibodies and seven types of anti-ganglioside antibodies, in children with autism.
  
  
  METHODS
  We conducted the study over a period of one year from May 2012 to December 2013. Human anti-GAD in serum were investigated with ELISA; human autoantibodies against the N-methyl-D-aspartate subtype of GluR were investigated with indirect immunofluorescence test; class IgG antibodies against the seven gangliosides were investigated with immunoblot assay.
  
  
  RESULTS
  Serum antineuronal antibodies were measured in 42 children (24 male, 18 female) with autism in comparison to 21 (13 male, 8 female) healthy-matched children aged between 2-12 years. There was no seropositivity of antineuronal antibodies in either of the groups.
  
  
  CONCLUSIONS
  There is no evidence to support an association between autism and antibodies positivity of anti-GAD, anti-GluR and anti-gangliosides (Ref. 26).
authors.forename: A K
authors.initials: AK
authors.lastname: Bayram
authors.forename: F
authors.initials: F
authors.lastname: Kardas
authors.forename: E O
authors.initials: EO
authors.lastname: Demirci
authors.forename: S
authors.initials: S
authors.lastname: Gokahmetoglu
authors.forename: S
authors.initials: S
authors.lastname: Ozmen
authors.forename: M
authors.initials: M
authors.lastname: Canpolat
authors.forename: D B
authors.initials: DB
authors.lastname: Oztop
authors.forename: S
authors.initials: S
authors.lastname: Kumandas
authors.forename: H
authors.initials: H
authors.lastname: Gumus
authors.forename: H
authors.initials: H
authors.lastname: Per
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D002490:Central Nervous System / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D008297:Male; D017470:Receptors, Glutamate / Q000276:immunology*; D013223:Statistics as Topic; D009435:Synaptic Transmission / Q000276:immunology; D005680:gamma-Aminobutyric Acid / Q000276:immunology
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; D017470:Receptors, Glutamate; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase
keywords: Autism; antineuronal antibodies; autoimmunity.; ganglioside antibodies; glutamate receptor; glutamic acid decarboxylase