title: Does cartilage volume measurement or radiographic osteoarthritis at baseline independently predict ten-year cartilage volume loss?
abstract: BACKGROUND
  The aim of this study was to examine whether cartilage volume as measured by MRI and radiographic osteoarthritis (OA) at baseline predict cartilage volume loss over ten years independent of each other and other structural co-pathologies.
  
  
  METHODS
  219 participants [mean-age 45(26-61); 57 % female] were studied at baseline and ten years. Approximately half were the adult offspring of subjects who underwent knee replacement for OA and the remainder were randomly selected controls. Joint space narrowing (JSN) and osteophytes were assessed on radiographs and cartilage volume (tibiofemoral), cartilage defects, bone marrow lesions and meniscal tears/extrusion were assessed on MRI.
  
  
  RESULTS
  Mean absolute and percentage per annum cartilage volume loss was 1284 mm(3) and 1.91 % respectively in the medial compartment and 1007 mm(3) and 1.38 % respectively in the lateral compartment. Higher baseline tibiofemoral cartilage volume was independently associated with greater absolute cartilage volume loss in both medial (β(95 % CI) = -300 (-399,-200)) and lateral (β = -338 (-443,-233)) compartments and percentage per annum loss in the lateral compartment(β = -0.15 (-0.29, -0.01)). Baseline JSN and osteophytes were associated with cartilage volume loss in the univariable analysis, however these associations did not persist after adjustment for other structural co-pathologies.
  
  
  CONCLUSIONS
  Cross-sectional cartilage volume measurement independently predicts cartilage volume loss over 10 years and can be used to identify fast progressors in clinical trials. Radiographic JSN and osteophytes on the other hand are a reflection of other co-pathologies assessed on MRI and do not independently predict cartilage volume loss over 10 years.
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23 17-Liverpool Street, Hobart, 7000, Australia. amcb25@yahoo.com.au.
authors.forename: Andrew
authors.initials: A
authors.lastname: McBride
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23 17-Liverpool Street, Hobart, 7000, Australia. Hussain.Khan@utas.edu.au.
authors.forename: Hussain Ijaz
authors.initials: HI
authors.lastname: Khan
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23 17-Liverpool Street, Hobart, 7000, Australia. Dawn.Aitken@utas.edu.au.
authors.forename: Dawn
authors.initials: D
authors.lastname: Aitken
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23 17-Liverpool Street, Hobart, 7000, Australia. louisa9285@hotmail.com.
authors.forename: Louisa
authors.initials: L
authors.lastname: Chou
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23 17-Liverpool Street, Hobart, 7000, Australia. ChangHai.Ding@utas.edu.au.
authors.forename: Changhai
authors.initials: C
authors.lastname: Ding
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23 17-Liverpool Street, Hobart, 7000, Australia. Leigh.Blizzard@utas.edu.au.
authors.forename: Leigh
authors.initials: L
authors.lastname: Blizzard
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada. dr@jppelletier.ca.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pelletier
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada. jm@martelpelletier.ca.
authors.forename: Johanne
authors.initials: J
authors.lastname: Martel-Pelletier
authors.affiliation: Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Flavia.Cicuttini@monash.edu.
authors.forename: Flavia
authors.initials: F
authors.lastname: Cicuttini
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23 17-Liverpool Street, Hobart, 7000, Australia. Graeme.Jones@utas.edu.au.
authors.forename: Graeme
authors.initials: G
authors.lastname: Jones
mesh_terms: D000328:Adult; D019645:Arthroplasty, Replacement, Knee; D002358:Cartilage, Articular / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors
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