title: Ultrasound and magnetic resonance imaging assessment of joint disease in symptomatic patients with cystic fibrosis arthropathy.
abstract: Cystic fibrosis arthropathy (CFA) is a term commonly used for joint pain with and without swelling seen in some patients with CF. Early studies into CFA focused on the presence of rheumatoid factor and immunological changes on synovial biopsy, with parallels drawn between respiratory and joint activity. Identification of anti-cyclic citrullinated peptide antibodies (anti-CCP) as a marker of rheumatoid arthritis (RA), along with increased access to sensitive imaging techniques including ultrasound (US) and magnetic resonance imaging (MRI), offer great potential to investigate and more accurately understand the type(s) of inflammatory arthritis that may underlie CFA. The aim of this study was to phenotype an active CFA cohort using serology and imaging, as a basis for further work in this understudied area.
  
  
  
  This was a prospective observational cohort study of symptomatic CFA patients presenting with joint pain. Participants underwent serological testing, clinical and US joint and entheseal assessment, as well as MRI of the most symptomatic joint/joint area.
  
  
  
  Ten symptomatic patients were studied with 9/10 having positive clinical findings. Inflammatory changes on US were seen in 8/10 cases. Five patients had positive findings on MRI (3 of whom had received IV gadolinium contrast). This included patients with significant erosive changes. One patient was anti-CCP positive suggestive of RA, and two were anti-nuclear antibody positive.
  
  
  
  Imaging, and to a lesser extent serology, identified inflammatory joint pathology in a proportion of cases, providing important data to explore in a large CFA cohort examining the clinical and imaging phenotype of this group.
authors.affiliation: Leeds Adult CF Unit, Leeds Teaching Hospitals NHS Trust, UK.
authors.forename: G
authors.initials: G
authors.lastname: Fitch
authors.affiliation: Leeds Adult CF Unit, Leeds Teaching Hospitals NHS Trust, UK.
authors.forename: K
authors.initials: K
authors.lastname: Williams
authors.affiliation: Department of Rheumatology, Leeds Teaching Hospitals NHS Trust, UK; NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, UK.
authors.forename: J E
authors.initials: JE
authors.lastname: Freeston
authors.affiliation: Department of Rheumatology, Leeds Teaching Hospitals NHS Trust, UK.
authors.forename: S
authors.initials: S
authors.lastname: Dass
authors.affiliation: Department of Radiology, Leeds Teaching Hospitals NHS Trust, UK; NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, UK.
authors.forename: A
authors.initials: A
authors.lastname: Grainger
authors.affiliation: NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, UK.
authors.forename: R
authors.initials: R
authors.lastname: Hodgson
authors.affiliation: NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, UK.
authors.forename: L
authors.initials: L
authors.lastname: Horton
authors.affiliation: Leeds Adult CF Unit, Leeds Teaching Hospitals NHS Trust, UK.
authors.forename: P
authors.initials: P
authors.lastname: Whitaker
authors.affiliation: Leeds Adult CF Unit, Leeds Teaching Hospitals NHS Trust, UK.
authors.forename: D
authors.initials: D
authors.lastname: Peckham
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis / Q000097:blood; D003550:Cystic Fibrosis / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007592:Joint Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000276:immunology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D062072:Patient Acuity; D011446:Prospective Studies; D013223:Statistics as Topic; D063189:Symptom Assessment / Q000379:methods; D014463:Ultrasonography / Q000379:methods; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D001323:Autoantibodies
keywords: Arthropathy; Cystic fibrosis; Joint count; MRI; Ultrasound