title: Improved Pharmacokinetics of Aceclofenac Immediate Release Tablets Incorporating its Inclusion Complex with Hydroxypropyl-β-Cyclodextrin.
abstract: The present investigation reports the various pharmacokinetic parameters of immediate release aceclofenac tablets incorporating its inclusion complex with hydroxypropyl-β-cyclodextrin. The tablets were prepared using aceclofenac: hydroxypropyl-β-cyclodextrin in a 1:1 molar ratio by the direct compression method (TKN). The results were compared with those of the marketed brand (MKT) and pure drug (TAC). The P-values indicated that mean plasma concentrations were significantly different among all three formulations administered (P<0.05, P<0.01). TKN showed significantly higher plasma levels when compared to the pure drug (P<0.01). The Cmax and AUC(0-∞) of TKN were significantly higher (P<0.05) compared to the pure drug and marketed formulation. Furthermore, the first-order overall elimination rate constant (Kel) of TKN was also significantly higher (P<0.05) compared to the pure drug and its marketed formulation. These results suggested that tablets prepared by incorporating the AC-HPβCD inclusion complex (TKN) would provide a more rapid onset of pharmacological effects in comparison to the marketed formulation and pure drug.
authors.affiliation: Department of Pharmaceutics, Globus College of Pharmacy, Bangrasia, Bhopal-462045, MP, India.
authors.forename: Sunita
authors.initials: S
authors.lastname: Dahiya
authors.affiliation: Department of Pharmaceutics, IPS College of Pharmacy, Gwalior, MP, India.
authors.forename: Atul
authors.initials: A
authors.lastname: Kaushik
authors.affiliation: Department of Pharmaceutics, Rajiv Academy for Pharmacy, Chhattikara, Mathura, UP, India.
authors.forename: Kamla
authors.initials: K
authors.lastname: Pathak
keywords: Bioavailability; Immediate release tablets; In vivo studies; Inclusion complex; Pharmacokinetic parameters
references.citation: Drug Dev Ind Pharm. 2006 Nov-Dec;32(10):1219-25
references.pmid: 17090444
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