title: A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift.
abstract: We investigated the increased risk of Clostridium difficile infection (CDI) caused by the combined use of antibiotics and an immunosuppressive drug in a mouse model. Our data showed that an approximate return to pretreatment conditions of gut microbiota occurred within days after cessation of the antibiotic treatment, whereas the recovery of gut microbiota was delayed with the combined treatment of antibiotics and dexamethasone, leading to an increased severity of CDI. An alteration of gut microbiota is a key player in CDI. Therefore, our data implied that immunosuppressive drugs can increase the risk of CDI through the delayed recovery of altered gut microbiota.
authors.affiliation: Department of Infectious Disease and Global Health, Tufts University, North Grafton, MA 01536, USA.|Department of Animal Resource and Science, Dankook University, Cheonan, Chungnam 31116, Republic of Korea.
authors.forename: Hyeun Bum
authors.initials: HB
authors.lastname: Kim
authors.affiliation: Department of Infectious Disease and Global Health, Tufts University, North Grafton, MA 01536, USA.|School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture, Ministry of Agriculture, Shanghai 200240, P.R. China.
authors.forename: Yuankai
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, FL 33612, USA.
authors.forename: Xingmin
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D016360:Clostridioides difficile / Q000187:drug effects* / Q000502:physiology; D003015:Clostridium Infections / Q000188:drug therapy* / Q000382:microbiology; D003907:Dexamethasone / Q000009:adverse effects* / Q000627:therapeutic use; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000382:microbiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D007166:Immunosuppressive Agents; D003907:Dexamethasone
keywords: Antibiotics; Clostridium difficile infection; Gut; Immunosuppressive drug; Microbiota
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