title: Can early protein restriction induce the development of binge eating?
abstract: We tested the hypothesis that perinatal undernourishment is a factor for binge eating. At 52 days rats born from dams fed on 17% protein (Control) or 8% protein (Undernourished) were distributed into four groups, two of which continued to be fed ad libitum chow and two were submitted to three consecutive Restricted/Refeeding (R/R) cycles. According to the following schedule: Control Naïve (from mothers fed 17% protein/no restriction phase); Control Restricted (from mothers fed 17% protein/restriction phase); Undernourished Naïve (from mothers fed 8% protein/no restriction phase); and Undernourished Restricted (from mothers fed 8% protein/restriction phase). Each cycle consisted of a restriction phase (in the first four days 40% of the mean daily individual chow intake was offered for consumption), followed by a refeeding phase (4 days of chow ad libitum). After the three cycles, all animals were subjected to a feeding test (chow diet and palatable food ad libitum for 24h). During the feeding test, the Undernourished Restricted demonstrated rebound hyperphagia during 2, 4 and 6h. These results suggest the perinatal undernourishment cannot contribute to a binge eating phenotype.
authors.affiliation: Post-Graduation in Neuropsychiatry and Behavioral Sciences, Health Sciences Center, Federal University of Pernambuco, Recife, Pernambuco, Brazil. Electronic address: madgefechine@yahoo.com.br.
authors.forename: Madge Farias
authors.initials: MF
authors.lastname: Fechine
authors.affiliation: Post-Graduation in Neuropsychiatry and Behavioral Sciences, Health Sciences Center, Federal University of Pernambuco, Recife, Pernambuco, Brazil. Electronic address: ftassiakarin@yahoo.com.br.
authors.forename: Tássia Karin
authors.initials: TK
authors.lastname: Borba
authors.affiliation: Institute of Integrated Medicine Prof. Fernando Figueira, Recife, Pernambuco, Brazil. Electronic address: eulalio@imip.org.br.
authors.forename: José Eulálio
authors.initials: JE
authors.lastname: Cabral-Filho
authors.affiliation: INRA, UMR1280 Physiologie des Adaptations Nutritionnelles, F-44096 Nantes, France. Electronic address: Francisco.Bolanos@univ-nantes.fr.
authors.forename: Francisco
authors.initials: F
authors.lastname: Bolaños-Jiménez
authors.affiliation: Department of Anatomy, Health Sciences Center, Federal University of Pernambuco, Recife, Pernambuco, Brazil. Electronic address: sanlopesufpe@gmail.com.
authors.forename: Sandra
authors.initials: S
authors.lastname: Lopes-de-Souza
authors.affiliation: Department of Nutrition, Health Sciences Center, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, Pernambuco CEP: 50670901, Brazil. Electronic address: manhaesdecastroraul@gmail.com.
authors.forename: Raul
authors.initials: R
authors.lastname: Manhães-de-Castro
mesh_terms: D000818:Animals; D001835:Body Weight; D002032:Bulimia / Q000209:etiology*; D018753:Diet, Protein-Restricted / Q000009:adverse effects*; D004435:Eating; D005247:Feeding Behavior; D005260:Female; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
keywords: Binge eating disorder; Caloric restriction; Hyperphagia; Perinatal undernutrition