title: Metaplastic thymoma with myasthenia gravis presumably caused by an accumulation of intratumoral immature T cells: a case report.
abstract: Among human neoplasms, thymomas are well known for their association with paraneoplastic autoimmune diseases such as myasthenia gravis. However, regarding rare metaplastic thymoma, only one case of an association with myasthenia gravis has been reported. Here, we present the second case of a 44-year-old woman with metaplastic thymoma associated with myasthenia gravis. In metaplastic thymoma, intratumoral terminal deoxynucleotidyl transferase-positive T-cells (immature T-cells) are generally scarce, while they were abundant in the present case. We believe that these immature T-cells could be related to the occurrence of myasthenia gravis.
authors.affiliation: Department of Pathology, Graduate School of Medicine, The University of Tokyo Tokyo, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Tajima
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medicine, The University of Tokyo Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yanagiya
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medicine, The University of Tokyo Tokyo, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sato
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medicine, The University of Tokyo Tokyo, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Nakajima
authors.affiliation: Department of Pathology, Graduate School of Medicine, The University of Tokyo Tokyo, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukayama
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D016246:Lymphocytes, Tumor-Infiltrating / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D008679:Metaplasia; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D013934:Thymectomy; D013945:Thymoma / Q000737:chemistry / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D013953:Thymus Neoplasms / Q000737:chemistry / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D002800:Cholinesterase Inhibitors; D005938:Glucocorticoids
keywords: Histology; immature T-cells; immunohistochemistry; metaplastic thymoma; myasthenia gravis
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