title: Submicrometer Hollow Bioglass Cones Deposited by Radio Frequency Magnetron Sputtering: Formation Mechanism, Properties, and Prospective Biomedical Applications.
abstract: This work reports on the unprecedented magnetron sputtering deposition of submicrometric hollow cones of bioactive glass at low temperature in the absence of any template or catalyst. The influence of sputtering conditions on the formation and development of bioglass cones was studied. It was shown that larger populations of well-developed cones could be achieved by increasing the argon sputtering pressure. A mechanism describing the growth of bioglass hollow cones is presented, offering the links for process control and reproducibility of the cone features. The composition, structure, and morphology of the as-synthesized hollow cones were investigated by energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), grazing incidence geometry X-ray diffraction (GIXRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM)-selected area electron diffraction (SAED). The in vitro biological performance, assessed by degradation tests (ISO 10993-14) and cytocompatibility assays (ISO 10993-5) in endothelial cell cultures, was excellent. This allied with resorbability and the unique morphological features make the submicrometer hollow cones interesting candidate material devices for focal transitory permeabilization of the blood-brain barrier in the treatment of carcinoma and neurodegenerative disorders.
authors.affiliation: National Institute of Materials Physics , 077125 Magurele, Ilfov, Romania.|Army Centre for Medical Research , 010195 Bucharest, Romania.
authors.forename: A C
authors.initials: AC
authors.lastname: Popa
authors.affiliation: National Institute of Materials Physics , 077125 Magurele, Ilfov, Romania.
authors.forename: G E
authors.initials: GE
authors.lastname: Stan
authors.affiliation: National Institute of Materials Physics , 077125 Magurele, Ilfov, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Besleaga
authors.affiliation: University of Bucharest , Faculty of Physics, 077125 Magurele, Ilfov, Romania.
authors.forename: L
authors.initials: L
authors.lastname: Ion
authors.affiliation: National Institute of Materials Physics , 077125 Magurele, Ilfov, Romania.
authors.forename: V A
authors.initials: VA
authors.lastname: Maraloiu
authors.affiliation: Turin Polytechnic University in Tashkent , 100095 Tashkent, Uzbekistan.
authors.forename: D U
authors.initials: DU
authors.lastname: Tulyaganov
authors.affiliation: Department of Materials and Ceramic Engineering, CICECO, University of Aveiro , 3810-193 Aveiro, Portugal.
authors.forename: J M F
authors.initials: JM
authors.lastname: Ferreira
mesh_terms: D001128:Argon / Q000737:chemistry; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology; D002460:Cell Line; D002516:Ceramics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D017550:Spectroscopy, Fourier Transform Infrared; D014025:Titanium / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: C022107:Bioglass; D020099:Coated Materials, Biocompatible; D001128:Argon; D014025:Titanium
keywords: bioglass cones; sputtering; structure; submicrometer needles; surfaces