title: Crystal engineering: co-crystals of cinnamic acid derivatives with a pyridyl derivative co-crystallizer.
abstract: A number of hydrogen-bonded co-crystals, consisting of a cinnamic acid derivative and a pyridyl co-crystallizer, have been synthesized and their properties investigated by X-ray diffraction. Samples were prepared by recrystallization or solvent drop grinding of trans-cinnamic acid (1), 4-methylcinnamic acid (2), 4-methoxy cinnamic acid (3) or 3,4-methoxy cinnamic acid (4), with 4,4-dipyridyl (A), iso-nicotinamide (B) or nicotinamide (C). The X-ray single-crystal structures of seven novel co-crystals, obtained through recrystallization, are examined and the hydrogen-bonding interactions discussed. Consistent hydrogen-bonding motifs were observed for samples prepared when using 4,4-dipyridyl (A) or iso-nicotinamide (B) as the co-crystallizing agent. Powder X-ray diffraction analysis of the samples prepared by solvent drop grinding suggests the formation of ten co-crystals.
authors.affiliation: Department of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, England.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Lorenzo
authors.affiliation: Department of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, England.
authors.forename: Sebastian J K
authors.initials: SJ
authors.lastname: Forrest
authors.affiliation: Department of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, England.
authors.forename: Hazel A
authors.initials: HA
authors.lastname: Sparkes
mesh_terms: D002934:Cinnamates / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D009536:Niacinamide / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: C000611789:4-methoxy cinnamic acid; D002934:Cinnamates; D011725:Pyridines; C029010:cinnamic acid; D009536:Niacinamide
keywords: cinnamic acid; co-crystal; solvent drop grinding