title: Serum and Vitreous Pentraxin 3 Concentrations in Patients with Diabetic Retinopathy.
abstract: OBJECTIVE
  Pentraxin 3 (PTX3), an acute-phase glycoprotein, is correlated with inflammation. Inflammation is mechanistically involved in the development of diabetic retinopathy (DR). This study was performed to investigate the association of serum and vitreous PTX3 concentrations with the occurrence of DR.
  
  
  METHODS
  This study enrolled 52 type 2 diabetes mellitus (T2DM) patients (20 without DR and 32 patients with proliferative diabetic retinopathy [PDR]). Serum and vitreous PTX3 concentrations were examined by using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  PDR patients showed significantly increased concentrations of serum and vitreous PTX3 concentrations compared with the control group and T2DM patients without DR. Higher serum and vitreous PTX3 concentrations were detected in T2DM patients without DR than those in the controls.
  
  
  CONCLUSIONS
  Serum and vitreous PTX3 concentrations are associated with the occurrence of DR.
authors.affiliation: 1 Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University , Tianjin, People's Republic of China .
authors.forename: Wen
authors.initials: W
authors.lastname: Zhou
authors.affiliation: 2 Department of Endocrinology, Qilu Hospital, Shandong University , Qingdao, People's Republic of China .
authors.forename: Wenchao
authors.initials: W
authors.lastname: Hu
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000097:blood / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins