title: Effect of exercise training and myocardial infarction on force development and contractile kinetics in isolated canine myocardium.
abstract: It is well known that moderate exercise training elicits a small increase in ventricular mass (i.e., a physiological hypertrophy) that has many beneficial effects on overall cardiac health. It is also well known that, when a myocardial infarction damages part of the heart, the remaining myocardium remodels to compensate for the loss of viable functioning myocardium. The effects of exercise training, myocardial infarction (MI), and their interaction on the contractile performance of the myocardium itself remain largely to be determined. The present study investigated the contractile properties and kinetics of right ventricular myocardium isolated from sedentary and exercise trained (10-12 wk progressively increasing treadmill running, begun 4 wk after MI induction) dogs with and without a left ventricular myocardial infarction. Exercise training increased force development, whereas MI decreased force development that was not improved by exercise training. Contractile kinetics were significantly slower in the trained dogs, whereas this impact of training was less or no longer present after MI. Length-dependent activation, both evaluated on contractile force and kinetics, was similar in all four groups. The control exercise-trained group exhibited a more positive force-frequency relationship compared with the sedentary control group while both sedentary and trained post-MI dogs had a more negative relationship. Last, the impact of the β-adrenergic receptor agonist isoproterenol resulted in a similar increase in force and acceleration of contractile kinetics in all groups. Thus, exercise training increased developed force but slowed contractile kinetics in control (noninfarcted animals), actions that were attenuated or completely absent in post-MI dogs.
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Canan
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and.
authors.forename: Kaylan M
authors.initials: KM
authors.lastname: Haizlip
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Monasky
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and.
authors.forename: Nitisha
authors.initials: N
authors.lastname: Hiranandani
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and.
authors.forename: Nima
authors.initials: N
authors.lastname: Milani-Nejad
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Varian
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Slabaugh
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Schultz
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.
authors.forename: Vadim V
authors.initials: VV
authors.lastname: Fedorov
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.
authors.forename: George E
authors.initials: GE
authors.lastname: Billman
authors.affiliation: Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; and Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio janssen.10@osu.edu.
authors.forename: Paul M L
authors.initials: PM
authors.lastname: Janssen
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D007545:Isoproterenol / Q000494:pharmacology; D007700:Kinetics; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism
chemical_list: D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol
keywords: Frank-Starling mechanism; contractility; force-frequency relationship; heart failure
references.citation: Cardiovasc Res. 2001 Jun;50(3):495-508
references.pmid: 11376625
references.citation: Cardiovasc Res. 2002 Apr;54(1):162-74
references.pmid: 12062372
references.citation: Am J Physiol Heart Circ Physiol. 2003 Mar;284(3):H772-8
references.pmid: 12424099
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1977 Dec;43(6):977-82
references.pmid: 146690
references.citation: J Appl Physiol (1985). 2006 Mar;100(3):896-906
references.pmid: 16322370
references.citation: Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1680-5
references.pmid: 16339826
references.citation: Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2590-9
references.pmid: 16387787
references.citation: Pharmacol Ther. 2006 Sep;111(3):808-35
references.pmid: 16483666
references.citation: J Appl Physiol (1985). 2007 Jan;102(1):231-40
references.pmid: 17008437
references.citation: Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2702-9
references.pmid: 17720768
references.citation: J Mol Cell Cardiol. 2007 Nov;43(5):523-31
references.pmid: 17919652
references.citation: Front Biosci. 2008 Jan 01;13:312-24
references.pmid: 17981549
references.citation: Pflugers Arch. 2008 May;456(2):267-76
references.pmid: 18057959
references.citation: Am J Cardiol. 1991 Nov 18;68(14):1D-6D
references.pmid: 1836091
references.citation: J Cardiovasc Pharmacol. 2008 Apr;51(4):352-8
references.pmid: 18427277
references.citation: Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1171-93
references.pmid: 19684184
references.citation: Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1219-28
references.pmid: 20097770
references.citation: Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1092-9
references.pmid: 20656885
references.citation: Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1741-9
references.pmid: 20852049
references.citation: Front Physiol. 2010 Sep 30;1:25
references.pmid: 21423367
references.citation: Front Physiol. 2011 Feb 14;2:3
references.pmid: 21423413
references.citation: Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2288-99
references.pmid: 21460198
references.citation: J Appl Physiol (1985). 2011 Oct;111(4):1159-67
references.pmid: 21778421
references.citation: Front Physiol. 2011 Nov 29;2:86
references.pmid: 22144961
references.citation: Mol Cell Biochem. 2012 Apr;363(1-2):203-15
references.pmid: 22160857
references.citation: Prog Cardiovasc Dis. 2012 Mar-Apr;54(5):387-96
references.pmid: 22386289
references.citation: J Appl Physiol (1985). 2012 Dec 1;113(11):1772-83
references.pmid: 23042911
references.citation: J Gen Physiol. 2013 Jan;141(1):133-9
references.pmid: 23277479
references.citation: Pharmacol Ther. 2014 Mar;141(3):235-49
references.pmid: 24140081
references.citation: Pflugers Arch. 2014 Jun;466(6):1113-27
references.pmid: 24519465
references.citation: JACC Heart Fail. 2013 Feb;1(1):1-20
references.pmid: 24621794
references.citation: Prog Cardiovasc Dis. 2015 Jan-Feb;57(4):347-55
references.pmid: 25459973
references.citation: J Appl Physiol (1985). 2015 Jun 1;118(11):1344-55
references.pmid: 25749448
references.citation: Biophys Rev. 2014 Dec;6(3-4):273-289
references.pmid: 28510030
references.citation: Acta Physiol Scand Suppl. 1986;556:33-43
references.pmid: 3471055
references.citation: Basic Res Cardiol. 1982 Nov-Dec;77(6):619-44
references.pmid: 7159359
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1980 Jan;48(1):130-8
references.pmid: 7353965
references.citation: J Mol Cell Cardiol. 1993 May;25(5):501-8
references.pmid: 8377211
references.citation: Am J Physiol. 1996 Jul;271(1 Pt 2):H73-9
references.pmid: 8760160
references.citation: Circulation. 1996 Aug 15;94(4):683-9
references.pmid: 8772688
references.citation: Cardiovasc Res. 1998 Feb;37(2):541-8
references.pmid: 9614508