title: The role of microRNAs in prostate cancer progression.
abstract: Prostate cancer (PCa) is the most common male malignancy and the second highest cause of cancer-related mortality in United States. MicroRNAs (miRNAs) are small non-coding RNAs that represent a new mechanism to regulate mRNA post-transcriptionally. It is involved in diverse physiological and pathophysiological process. Dysregulation of miRNAs has been associated with the multistep progression of PCa from prostatic intraepithelial neoplasia (PIN), localized adenocarcinoma to metastatic castration-resistance PCa (CRPC). Identification of unique miRNA could provide new biomarkers for PCa and develop into therapeutic strategies. In this review, we will summarize a broad spectrum of both tumor suppressive and oncogenic miRNAs, and their mechanisms contribute to prostate carcinogenesis.
authors.affiliation: Departments of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: U-Ging
authors.initials: UG
authors.lastname: Lo
authors.affiliation: Departments of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Yang
authors.affiliation: Departments of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Jer-Tsong
authors.initials: JT
authors.lastname: Hsieh
keywords: Androgen receptor (AR); castration-resistant prostate cancer (CRPC); epithelial-to-mesenchymal transition (EMT); microRNA (miRNA)
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