title: Donors' health state the year after peripheral haematopoietic progenitor cell collection: A prospective follow-up study in related and unrelated donors compared to first-time platelet donors.
abstract: Granulocyte colony-stimulating factor (G-CSF) mobilized peripheral haematopoietic progenitor cells collected by apheresis (HPC-A) are the most common source used for allogeneic hematopoietic stem cell transplantation (HSCT). Retrospective short and long-term donor follow-up studies show very low risks of serious complications and do not report compelling evidence of increased cancer occurrence. Some studies reported a prolonged period of leucopenia without an obvious association with infectious complications. However, beyond the first few weeks after the procedure a relationship between events is elusive. We therefore evaluated medical service utilization by prospectively recruited HPC-A donors and first-time platelet apheresis donors for comparison for 1 year after donation. Data were prospectively collected using questionnaires and by medical record review. A total of 215 HPC-A donors (111 unrelated donors and 104 related donors) and 96 first-time platelet donors consented to participation in the study. Follow-up was available for 202 (96%): questionnaires were returned by 74% and records from nonstudy contacts were available for 94% of donors. During the 1-year follow-up, 94 of the donors who returned questionnaires sought medical attention for diagnostic evaluation and/or treatment: 41% of HPC-A donors and 40% of platelet donors. Medical service utilization the first year after HPC-A donation is similar to that after first-time platelet donation. The occurrence of serious medical conditions in both related and unrelated HPC-A donors underscores the importance of participation in long-term follow-up in large cohorts. The findings in this relatively small cohort contribute to evidence on the safety of G-CSF mobilization and HPC-A. J. Clin. Apheresis 31:523-528, 2016. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Sanquin - LUMC Jon J. Van Rood Centre for Clinical Transfusion Research, Leiden, the Netherlands.|Center for Innovation in Medical Education, Leiden University Medical Center, Leiden, the Netherlands.
authors.forename: I
authors.initials: I
authors.lastname: Bank
authors.affiliation: Donor Services Unit, Sanquin Blood Supply, Leiden, the Netherlands.|TRIP Hemovigilance and Biovigilance Office, Leiden, the Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Wiersum-Osselton
authors.affiliation: TRIP Hemovigilance and Biovigilance Office, Leiden, the Netherlands.|Europdonor Foundation, Leiden, the Netherlands.
authors.forename: S M
authors.initials: SM
authors.lastname: Van Walraven
authors.affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, the Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Netelenbos
authors.affiliation: Europdonor Foundation, Leiden, the Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Fechter
authors.affiliation: Donor Services Unit, Sanquin Blood Supply, Leiden, the Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Marijt-van der Kreek
authors.affiliation: Stem Cell Donor Bank Europdonor Nijmegen, Nijmegen, the Netherlands.
authors.forename: B M A M
authors.initials: BM
authors.lastname: Bär
authors.affiliation: Sanquin - LUMC Jon J. Van Rood Centre for Clinical Transfusion Research, Leiden, the Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: Van der Bom
authors.affiliation: Sanquin - LUMC Jon J. Van Rood Centre for Clinical Transfusion Research, Leiden, the Netherlands.|Europdonor Foundation, Leiden, the Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Brand
mesh_terms: D064591:Allografts; D001781:Blood Component Removal / Q000379:methods*; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D055991:Health Records, Personal; D006304:Health Status; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells; D006801:Humans; D061214:Patient Safety; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods; D010983:Plateletpheresis; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D014019:Tissue Donors
chemical_list: D016179:Granulocyte Colony-Stimulating Factor
keywords: HPC-a; granulocyte colony-stimulating factor; health state; peripheral haematopoietic progenitor cell collection; platelet donors