title: Prevalence of the stages of chronic kidney disease (CKD) according to simplified MDRD formula in patients from ambulatory settings.
abstract: BACKGROUND
  The staging system of chronic kidney disease (CKD) classification plays an important role in patients stratification according to disease activity. The aim of the study was to evaluate the frequency of appearance of consecutive stages of chronic kidney disease based on simplified MDRD formula in patients with diagnosed CKD. Additionally, relationship between eGFR values and selected biochemical parameters and comorbidities were analyzed.
  
  
  METHODS
  The study was performed retrospectively in the group of 1176 patients (636 males and 540 females) aged between 17-98 years (mean 64.7) with creatinine level > 120 μmol/l and/or creatinine clearance < 90 ml/min/1.73 m2.
  
  
  RESULTS
  The highest percentage of patients were designated to the 3rd CKD stage. There were positive correlations between eGFR and Hb, Ht, Fe, LDL-Ch, AspAT, HbA1c and negative correlations between eGFR and age, mean and systolic blood pressure, as well as with P, K, iPTH, and uric acid concentration. Patients with cardiovascular diseases had significaintly lower eGFR values as compare with patients without such complications, respectively: atrial fibrillation, arterial hypertension, chronic heart failure, ischaemic heart disease (p < 0.01), and myocardial infarction (p < 0.04).
  
  
  CONCLUSIONS
  The highest percentage of patients with diagnosed CKD belong to the 3rd stage of disease. Patients with cardiovascular complications have significantly lower eGFR as compared with those without such disturbances.
authors.forename: Marcin
authors.initials: M
authors.lastname: Krzanowski
authors.forename: Rafał
authors.initials: R
authors.lastname: Januszek
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Krzanowska
authors.forename: Marek
authors.initials: M
authors.lastname: Kuźniewski
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kopeć
authors.forename: Eve
authors.initials: E
authors.lastname: Chowaniec
authors.forename: Władysław
authors.initials: W
authors.lastname: Sułowicz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D015897:Comorbidity; D005260:Female; D005919:Glomerular Filtration Rate; D006331:Heart Diseases / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000453:epidemiology*; D012189:Retrospective Studies; D055815:Young Adult