title: The mitogenome of Onchocerca volvulus from the Brazilian Amazonia focus.
abstract: We report here the first complete mitochondria genome of Onchocerca volvulus from a focus outside of Africa. An O. volvulus mitogenome from the Brazilian Amazonia focus was obtained using a combination of high-throughput and Sanger sequencing technologies. Comparisons made between this mitochondrial genome and publicly available mitochondrial sequences identified 46 variant nucleotide positions and suggested that our Brazilian mitogenome is more closely related to Cameroon-origin mitochondria than West African-origin mitochondria. As well as providing insights into the origins of Latin American onchocerciasis, the Brazilian Amazonia focus mitogenome may also have value as an epidemiological resource.
authors.affiliation: Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus, AM, Brasil.
authors.forename: James L
authors.initials: JL
authors.lastname: Crainey
authors.affiliation: Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus, AM, Brasil.
authors.forename: Túllio R R da
authors.initials: TR
authors.lastname: Silva
authors.affiliation: Laboratório de Genética Molecular de Microorganismos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Encinas
authors.affiliation: Laboratório de Genética Molecular de Microorganismos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
authors.forename: Michel A
authors.initials: MA
authors.lastname: Marín
authors.affiliation: Laboratório de Genética Molecular de Microorganismos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
authors.forename: Ana Carolina P
authors.initials: AC
authors.lastname: Vicente
authors.affiliation: Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus, AM, Brasil.
authors.forename: Sérgio L B
authors.initials: SL
authors.lastname: Luz
mesh_terms: D000818:Animals; D001938:Brazil; D002163:Cameroon; D054629:Genome, Mitochondrial / Q000235:genetics*; D017181:Onchocerca volvulus / Q000235:genetics*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
references.citation: Int J Parasitol. 2000 Dec;30(14):1459-65
references.pmid: 11428336
references.citation: Exp Parasitol. 1999 Dec;93(4):198-206
references.pmid: 10600445
references.citation: Mol Ecol Resour. 2009 Mar;9(2):480-6
references.pmid: 21564677
references.citation: Mem Inst Oswaldo Cruz. 2014 Jul;109(4):506-8
references.pmid: 25075790
references.citation: Acta Trop. 2014 Mar;131:47-55
references.pmid: 24200838
references.citation: J Helminthol. 2006 Sep;80(3):281-90
references.pmid: 16923273
references.citation: Infect Genet Evol. 2009 Sep;9(5):748-59
references.pmid: 19539785
references.citation: Mol Biochem Parasitol. 1998 Sep 1;95(1):111-27
references.pmid: 9763293
references.citation: Bioinformatics. 2000 Oct;16(10):944-5
references.pmid: 11120685
references.citation: Mem Inst Oswaldo Cruz. 2010 Sep;105(6):823-8
references.pmid: 20945000
references.citation: Mem Inst Oswaldo Cruz. 2007 Nov;102(7):879-82
references.pmid: 17992364
references.citation: Acta Trop. 2013 Aug;127(2):118-25
references.pmid: 23545131