title: [Preparation and performance characterization of pseudo-ginseng entrapped in crosslinked chitosan/polyacrylic acid/poly(ethylene oxide) nanofibrous membrane].
abstract: To prepare the cross-linked chitosan/poly(acrylic acid)/poly (ethylene oxide) nanofibrous membrance loaded with pseudo-ginseng and to determine its characteristics.
  
  
  
  Pseudo-ginseng entrapped in chitosan, poly (acrylic acid), poly (ethylene oxide) nanofibrous membrane loaded with pseudo-ginseng was prepared by electrospinning and thermal treatment method. The surface morphology of fiber membrane was observed by scanning electron microscopy and the chemical structures were characterized by infrared spectroscopy; the thermal decomposition temperature was analyzed by the thermogravimetric analysis. UV-Vis spectra were used to evaluate the in vitro release properties.
  
  
  
  The average diameter of the prepared nanofibrous particles was (181 ± 71) nm. The tensile strength of fiber membrane increased by 35.3% and the decomposition temperature increased from 197℃ to 208℃ after crosslinking. Compared with casting film, the structure of fiber membrane increased the release rate and the overall amount of active components from pseudo-ginseng.
  
  
  
  The preparation of chitosan fiber loaded with pseudo-ginseng is simple and the dispersion of pseudo-ginseng is homogeneous. This fibrous pseudo-ginseng exhibited good release performance, providing a new Chinese medicine formulation.
authors.affiliation: School of Medical Sciences, Shaoxing University, Shaoxing 312000, China.
authors.forename: Gui-ying
authors.initials: GY
authors.lastname: Xing
authors.affiliation: College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, China.
authors.forename: Lin-jun
authors.initials: LJ
authors.lastname: Shao
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D005894:Panax / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D004365:Drugs, Chinese Herbal; C065246:chitosan-poly(acrylic acid); D011092:Polyethylene Glycols; D048271:Chitosan
references.citation: AAPS PharmSciTech. 2012 Mar;13(1):101-11
references.pmid: 22160883
references.citation: J Mater Sci Mater Med. 2012 Nov;23(11):2709-16
references.pmid: 22875606
references.citation: Mater Sci Eng C Mater Biol Appl. 2013 Jan 1;33(1):461-5
references.pmid: 25428096