title: Recent achievements in colorectal cancer diagnostic and therapy by the use of nanoparticles.
abstract: Colorectal cancer is a major public health issue, being the third most common cancer in men and the second in women. It is one of the leading causes of cancer deaths. Nanomedicine is an emerging field of interest, many of its aspects being linked to cancer research. Chemotherapy has a well-established role in colorectal cancer management, unfortunately being limited by inability to have a selective distribution, by multidrug resistance and adverse effects. Researches carried out in recent years about nanotechnologies aimed, among others, to resolve the issues mentioned above. Targeted and localized delivery of the chemotherapeutic drugs, using nanoparticles, with selective destruction of cancerous cells would minimize the toxicity on healthy tissues. Also, the use of nanomaterials as contrast agent could improve sensitivity and specificity of diagnosis. The purpose of this review is to highlight the recent achievements of cancer research by use of nanomaterials, in the idea of finding the ideal composite, capable to simultaneous diagnostic and treat cancer.
authors.affiliation: a Department of Surgery , "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology , Cluj Napoca , Romania .
authors.forename: Adrian
authors.initials: A
authors.lastname: Bartoş
authors.affiliation: b Department of Surgery , "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology; Anatomy and Embryology Department, UMF "Iuliu Haţieganu" , Cluj-Napoca , Romania .
authors.forename: Dana
authors.initials: D
authors.lastname: Bartoş
authors.affiliation: c Department of Ophthalmology , Clinical Emergency Hospital Cluj; Anatomy and Embryology Department, UMF "Iuliu Haţieganu" , Cluj-Napoca , Romania .
authors.forename: Bianca
authors.initials: B
authors.lastname: Szabo
authors.affiliation: d Department of Anesthesiology and Intensive Care , "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, Department of Anesthesiology and Intensive Care, UMF "Iuliu Haţieganu" , Cluj-Napoca , Romania .
authors.forename: Caius
authors.initials: C
authors.lastname: Breazu
authors.affiliation: e Anatomy and Embryology Department , UMF "Iuliu Haţieganu" , Cluj-Napoca , Romania .
authors.forename: Iulian
authors.initials: I
authors.lastname: Opincariu
authors.affiliation: f Department of Surgery , Clinical Emergency Hospital; Department of Surgery No II, UMF ''Iuliu Haţieganu'' , Cluj Napoca , Romania , and.
authors.forename: Aurel
authors.initials: A
authors.lastname: Mironiuc
authors.affiliation: g Department of Surgery , " Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, Department of Surgery No III, UMF "Iuliu Haţieganu" , Cluj-Napoca , Romania.
authors.forename: Cornel
authors.initials: C
authors.lastname: Iancu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D058990:Molecular Targeted Therapy; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media
keywords: Colorectal cancer; chemotherapy; drug resistance; nanotechnology; targeted therapy