title: Respiratory manifestations and management in children with Common Variable Immunodeficiency.
abstract: Common variable immunodeficiency is an antibody deficiency that usually presents in childhood with recurrent sino-pulmonary infections. Diagnostic delay is frequent and thus respiratory morbidity is common, ranging from recurrent suppurative bronchitis to bronchiectasis. Immunoglobulin replacement therapy is the mainstay of treatment, whilst prophylactic antibiotic therapy and muco-ciliary clearance are additional treatment options. This review examines the diagnosis and management of respiratory issues in children with CVID.
authors.affiliation: Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney. Electronic address: chetan.pandit@health.nsw.gov.au.
authors.forename: Chetan
authors.initials: C
authors.lastname: Pandit
authors.affiliation: Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney; Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney.
authors.forename: Peter
authors.initials: P
authors.lastname: Hsu
authors.affiliation: Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney.
authors.forename: Peter
authors.initials: P
authors.lastname: van Asperen
authors.affiliation: Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney; Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney.
authors.forename: Sam
authors.initials: S
authors.lastname: Mehr
mesh_terms: D002648:Child; D017074:Common Variable Immunodeficiency / Q000150:complications*; D019468:Disease Management; D006801:Humans; D008171:Lung Diseases / Q000209:etiology* / Q000276:immunology* / Q000628:therapy*
keywords: Common variable immunodeficiency; Diagnosis; Respiratory management