title: Diagnostic Approach to Hepatic Mass Lesions and Role of Immunohistochemistry.
abstract: This review provides an overview of various hepatic mass lesions and a practical diagnostic approach, including most recent immunohistochemical stains used in clinical practice. A wide variety of benign and malignant lesions present as hepatic masses, and the differential diagnosis varies. In cirrhotic liver, the commonest malignant tumor is hepatocellular carcinoma (HCC), which needs to be differentiated from macroregenerative nodules, dysplastic nodules, and other tumors. The differential diagnosis of lesions in noncirrhotic liver in younger patients includes hepatic adenoma (HA), focal nodular hyperplasia (FNH), HCC, and other primary hepatic neoplasms and metastases. In older populations, metastases remain the most common mass lesions.
authors.affiliation: Department of Pathology, The Ottawa Hospital, Ottawa University, CCW- Room 4251, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada. Electronic address: cmarginean@toh.on.ca.
authors.forename: Esmeralda Celia
authors.initials: EC
authors.lastname: Marginean
authors.affiliation: PhenoPath Laboratories, Seattle, WA 98103, USA.
authors.forename: Allen M
authors.initials: AM
authors.lastname: Gown
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8023, USA.
authors.forename: Dhanpat
authors.initials: D
authors.lastname: Jain