title: The pharmacokinetic characters of simvastatin after co-administration with Shexiang Baoxin Pill in healthy volunteers' plasma.
abstract: To investigate the effect of Shexiang Baoxin Pill (SBP), a tranditional Chinese medicine, on the pharmacokinetic (PK) parameters of simvastatin in healthy volunteers' plasma, a quantitative method was developed using an Agilent G6410A rapid performance liquid chromatography (RPLC) coupled with triple quadrupole mass spectrometry system. The established method was rapid with high extraction recovery and successfully applied for the determination of simvastatin in plasma of 16 healthy volunteers. The results demonstrated that the MRT(0-∞), T1/2 and Tmax value of simvastatin were significantly decreased, while the AUC(0-t) and Cmax values of smivastatin were increased by SBP. The pharmacokinetic study demonstrated that the metabolism parameters of simvastatin could be affected by SBP and the potential drug-drug interaction should be noted in the future clinical practice.
authors.affiliation: Pharmacy Department, Shanghai Yangsi Hosipital, Shanghai 200126, PR China.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Tao
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China; Shanghai Hutchison Pharmaceuticals Company, Shanghai 200331, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Jiang
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200030, PR China.
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: Department of Ophthalmology, Shanghai Tenth People's Hospital Affiliated with Tongji University, School of Medicine, Shanghai 200072, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Runhui
authors.initials: R
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200030, PR China. Electronic address: wdzhangy@hotmail.com.
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D064368:Healthy Volunteers; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D012015:Reference Standards; D019821:Simvastatin / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D004365:Drugs, Chinese Herbal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C526712:shexiang baoxin; D019821:Simvastatin
keywords: Healthy volunteers; Pharmacokinetics; Shexiang Baoxin Pill; Simvastatin