title: SOCS1 in cancer: An oncogene and a tumor suppressor.
abstract: The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene.
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada. Electronic address: claudia.beaurivage@usherbrooke.ca.
authors.forename: Claudia
authors.initials: C
authors.lastname: Beaurivage
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada. Electronic address: audrey.champagne@usherbrooke.ca.
authors.forename: Audrey
authors.initials: A
authors.lastname: Champagne
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada. Electronic address: william.sam.tobelaim@usherbrooke.ca.
authors.forename: William S
authors.initials: WS
authors.lastname: Tobelaim
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada. Electronic address: veronique.pomerleau@usherbrooke.ca.
authors.forename: Véronique
authors.initials: V
authors.lastname: Pomerleau
authors.affiliation: Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada. Electronic address: alfredo.menendez@usherbrooke.ca.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Menendez
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada. Electronic address: caroline.saucier@usherbrooke.ca.
authors.forename: Caroline
authors.initials: C
authors.lastname: Saucier
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009857:Oncogenes; D000071222:Suppressor of Cytokine Signaling 1 Protein / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C108944:SOCS1 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein; D025521:Tumor Suppressor Proteins
keywords: Cancer; Colorectal cancer; Cytokine; Oncogene; SOCS1; Tumor suppressor