title: Expression of NF-κB-inducing kinase in breast carcinoma tissue and its clinical significance.
abstract: OBJECTIVE
  To investigate the expression of nuclear factor-κB-inducing kinase (NIK) in breast carcinoma tissue and tumor-adjacent normal breast tissue and evaluate its clinical significance.
  
  
  METHODS
  Surgically resected tissue specimens were collected from 82 patients with breast carcinoma who underwent surgical treatment at our hospital from March 2001 to December 2009. The diagnoses of all patients were confirmed by postoperative pathological examinations. NIK protein expression in breast carcinoma tissue and adjacent normal breast tissue was detected by immunohistochemistry; the association between NIK expression and the clinicopathological features and prognosis of patients with breast carcinoma was examined.
  
  
  RESULTS
  The positive expression rate of NIK in breast carcinoma tissue was significantly higher than that in normal tissue (63.4% vs. 25.6%, P < 0.05). Additionally, NIK expression showed no relationship to the tumor size, age, degree of differentiation, or pathological type; however, it showed a significant correlation with lymph node metastasis and the clinical stage of patients (P < 0.05). The five-year survival rate was significantly lower in breast carcinoma patients who were positive for NIK expression than in those who were negative for NIK expression (P = 0.006).
  
  
  CONCLUSIONS
  NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.
authors.affiliation: Department of Oncology, The Affiliated Hospital of Hubei Institute of Science and Technology, Huangshi Central Hospital Huangshi, Hubei, China.
authors.forename: Xuliang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Oncology, The Affiliated Hospital of Hubei Institute of Science and Technology, Huangshi Central Hospital Huangshi, Hubei, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Oncology, The Affiliated Hospital of Hubei Institute of Science and Technology, Huangshi Central Hospital Huangshi, Hubei, China.
authors.forename: Zheyu
authors.initials: Z
authors.lastname: Mao
authors.affiliation: Department of Oncology, The Affiliated Hospital of Hubei Institute of Science and Technology, Huangshi Central Hospital Huangshi, Hubei, China.
authors.forename: Danqing
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Oncology, The Affiliated Hospital of Hubei Institute of Science and Technology, Huangshi Central Hospital Huangshi, Hubei, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Oncology, The Affiliated Hospital of Hubei Institute of Science and Technology, Huangshi Central Hospital Huangshi, Hubei, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000201:enzymology / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis*; D000097782:NF-kappaB-Inducing Kinase
chemical_list: D014408:Biomarkers, Tumor; D017346:Protein Serine-Threonine Kinases; D000097782:NF-kappaB-Inducing Kinase
keywords: Breast carcinoma; NF-κB-inducing kinase
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