title: A Meta-Analysis of the Association Between the I148M Variant of Patatin-Like Phospholipase Domain Containing 3 Gene and the Presence of Chronic Hepatitis C.
abstract: BACKGROUND
  The objective of the current study was to evaluate the association between the I148M variant of patatin-like phospholipase domain-containing protein 3 (PNPLA3) and the presence of Chronic Hepatitis C (CHC) across different populations.
  
  
  METHODS
  This study was a meta-analysis of all relevant researches published in the literature from year 2000 to 2015. The odds ratios (ORs) of PNPLA3 allele distributions in CHC patients were analyzed and compared with healthy controls. The meta-analysis Revman 5.2 software was applied for investigating heterogeneity among individual studies and for summarizing all the studies. The meta-analysis was carried out according to the Cochrane Reviewers' Handbook recommendations. A total of 120 clinical trials or reports were retrieved, yet only five trials met the study selection criteria.
  
  
  RESULTS
  Five hospital-based case-control studies were included in the final analysis. The overall frequency of PNPLA3 gene polymorphisms was 20.4% (205/1005) in CHC and 10.23% (53/518) in controls. The summary odds ratio for the association of gene polymorphisms of PNPLA3 with the risk for CHC was determined as 2.20 (95% CI: 1.56 -3.11) and was statistically significant (P < 0.05).
  
  
  CONCLUSIONS
  The current meta-analysis showed an association between frequency of GG genotype of PNPLA3 and the risk of development of CHC in various populations throughout the world.
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital of Medical College, Qingdao University, Qingdao, China; Department of Gastroenterology, Qingdao Central Hospital, Qingdao, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital of Medical College, Qingdao University, Qingdao, China; Department of Gastroenterology, Qingdao Central Hospital, Qingdao, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xue
authors.affiliation: Medical College, Qingdao University, Qingdao, China.
authors.forename: Lizhen
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital of Medical College, Qingdao University, Qingdao, China; Department of Gastroenterology, Qingdao Central Hospital, Qingdao, China.
authors.forename: Shunshun
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Yongning
authors.initials: Y
authors.lastname: Xin
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Shiying
authors.initials: S
authors.lastname: Xuan
keywords: CHC; PNPLA3; Polymorphisms
references.citation: BMC Gastroenterol. 2012 Aug 16;12:111
references.pmid: 22898488
references.citation: J Hepatol. 2008 Oct;49(4):634-51
references.pmid: 18715665
references.citation: Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7892-7
references.pmid: 20385813
references.citation: Hepatology. 2011 May;53(5):1776; author reply 1777
references.pmid: 21351112
references.citation: Int J Cardiol. 2014 Mar 1;172(1):291-2
references.pmid: 24461483
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: World J Gastroenterol. 2013 Nov 7;19(41):6969-78
references.pmid: 24222941
references.citation: Viruses. 2012 Oct 19;4(10):2251-90
references.pmid: 23202463
references.citation: Gastroenterology. 2006 May;130(6):1636-42
references.pmid: 16697727
references.citation: Infect Genet Evol. 2014 Jan;21:179-83
references.pmid: 24269995
references.citation: Hepatology. 2011 Jul;54(1):60-9
references.pmid: 21488075
references.citation: Gastroenterology. 2009 Aug;137(2):549-57
references.pmid: 19445938
references.citation: J Viral Hepat. 2012 Sep;19(9):608-14
references.pmid: 22863264
references.citation: J Biol Chem. 2010 Feb 26;285(9):6706-15
references.pmid: 20034933
references.citation: Hepatology. 2011 Mar;53(3):791-9
references.pmid: 21319195
references.citation: J Hepatol. 2012 Dec;57(6):1276-82
references.pmid: 22878467
references.citation: Liver Int. 2009 Jan;29 Suppl 1:89-99
references.pmid: 19207971
references.citation: Nat Genet. 2008 Dec;40(12):1461-5
references.pmid: 18820647
references.citation: Stat Med. 2002 Jun 15;21(11):1513-24
references.pmid: 12111917
references.citation: JAMA. 2002 Jun 5;287(21):2801-4
references.pmid: 12038917
references.citation: Hepat Mon. 2014 Dec 24;14(12):e22915
references.pmid: 25685164
references.citation: J Hypertens. 2007 Jan;25(1):5-13
references.pmid: 17143166
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: J Hepatol. 2013 May;58(5):875-82
references.pmid: 23321320
references.citation: Hepatology. 2004 May;39(5):1230-8
references.pmid: 15122751
references.citation: Gut. 2009 Jun;58(6):846-58
references.pmid: 19074178
references.citation: PLoS One. 2011;6(11):e27087
references.pmid: 22087248
references.citation: Cell Metab. 2012 May 2;15(5):691-702
references.pmid: 22560221
references.citation: Am J Gastroenterol. 2014 Mar;109(3):325-34
references.pmid: 24445574
references.citation: Res Nurs Health. 2003 Aug;26(4):322-33
references.pmid: 12884420