title: Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.
abstract: Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present study potentially demonstrates that the autoimmune process elicited by AGA and/or Ro/SSA may play a role in promoting idiopathic NSIP independently of the typical ARS routes, which has not been reported thus far.
authors.affiliation: Clinic of Allergy and Clinical Immunology, Clinical Center of Serbia, Serbia.
authors.forename: Sladjana
authors.initials: S
authors.lastname: Andrejevic
authors.forename: Branislava
authors.initials: B
authors.lastname: Milenkovic
authors.forename: Jelena
authors.initials: J
authors.lastname: Stojsic
authors.forename: Ruza
authors.initials: R
authors.lastname: Stevic
authors.forename: Branka
authors.initials: B
authors.lastname: Bonaci-Nikolic
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D001323:Autoantibodies / Q000276:immunology*; D001706:Biopsy; D003371:Cough / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D015200:Fluoroimmunoassay; D006056:Golgi Apparatus / Q000276:immunology*; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012261:Ribonucleoproteins / Q000276:immunology*; D014057:Tomography, X-Ray Computed; D000099207:SS-A Antigen
chemical_list: D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D012261:Ribonucleoproteins; D000099207:SS-A Antigen