title: Association of 25-hydroxyvitamin D status with obesity as well as blood glucose and lipid concentrations in children and adolescents in China.
abstract: BACKGROUND
  Vitamin D is an essential micronutrient during the growth and development of the human body. Previously, most of the researches about the relationship of vitamin D and obesity were focused on adults. In this paper, the relationship between serum 25-hydroxyvitamin D [25(OH)D] and obesity among children and adolescents in China was analyzed.
  
  
  METHODS
  From August 2012 to August 2014, 443 children and adolescents participated in this study. Serum 25(OH)D, lipid and glucose were measured in the laboratory. All the participants were classified into 2 groups (obese and non-obese group) on the basis of their BMI. They were then categorized into vitamin D deficiency, vitamin D insufficiency and vitamin D normal groups according to the serum concentrations of 25(OH)D.
  
  
  RESULTS
  The concentration of serum 25(OH)D in the obese group was significantly lower than that of the non-obese group (P<0.001). The concentration of total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, fasting insulin and homeostasis model assessment for insulin resistance showed significant differences between the obese and non-obese groups (P<0.05).
  
  
  CONCLUSIONS
  Children and adolescents suffering from obesity are more likely to have lower concentrations of serum 25(OH)D.
authors.affiliation: Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, China; Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xian
authors.affiliation: Medical Administration Department, The 452nd Hospital of People's Liberation Army of China, China.
authors.forename: Min
authors.initials: M
authors.lastname: Min
authors.affiliation: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China.
authors.forename: Qingkai
authors.initials: Q
authors.lastname: Dai
authors.affiliation: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, China. Electronic address: dzfang@scu.edu.cn.
authors.forename: Dingzhi
authors.initials: D
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D001786:Blood Glucose; D008055:Lipids; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Blood glucose; Blood lipid metabolism; Obesity; Vitamin D