title: Bangle (Zingiber purpureum) Improves Spatial Learning, Reduces Deficits in Memory, and Promotes Neurogenesis in the Dentate Gyrus of Senescence-Accelerated Mouse P8.
abstract: Bangle (Zingiber purpureum) is a tropical ginger that is used as a spice in Southeast Asia. Phenylbutenoid dimers isolated from Bangle have exhibited neurotrophic effects in primary cultured rat cortical neurons and PC12 cells. Furthermore, chronic treatment with phenylbutenoid dimers enhances hippocampal neurogenesis in olfactory bulbectomized mice. In this study, we investigated the effects of Bangle extract on behavior and hippocampal neurogenesis in vivo. SAMP8 mice, which are an established model for accelerated aging, with age-related learning and memory impairments, were given a Bangle-containing diet for 1 month, and subsequent behavioral tests and immunohistochemistry for Ki67, a proliferating cell marker, were performed. We found that the Bangle-containing diet improved spatial learning and memory deficits in the Morris water maze and significantly increased the numbers of Ki67-positive cells in the dentate gyrus of the SAMP8 mice. In addition, the Bangle extract exhibited a neurotrophin-like activity as indicated by the induction of neurite sprouting in PC12 cells. Our results suggest that Bangle is beneficial for the prevention of age-related progression of cognitive impairment.
authors.affiliation: 1 Department of Pharmacy, Kochi Medical Graduate School , Kochi, Japan .|2 Department of Pharmacy, Kochi Medical School Hospital , Kochi, Japan .
authors.forename: Megumi
authors.initials: M
authors.lastname: Nakai
authors.affiliation: 2 Department of Pharmacy, Kochi Medical School Hospital , Kochi, Japan .
authors.forename: Michiro
authors.initials: M
authors.lastname: Iizuka
authors.affiliation: 3 Faculty of Pharmaceutical Sciences, Tokushima Bunri University , Tokushima, Japan .
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Matsui
authors.affiliation: 1 Department of Pharmacy, Kochi Medical Graduate School , Kochi, Japan .
authors.forename: Kazuko
authors.initials: K
authors.lastname: Hosogi
authors.affiliation: 2 Department of Pharmacy, Kochi Medical School Hospital , Kochi, Japan .
authors.forename: Akiko
authors.initials: A
authors.lastname: Imai
authors.affiliation: 1 Department of Pharmacy, Kochi Medical Graduate School , Kochi, Japan .|2 Department of Pharmacy, Kochi Medical School Hospital , Kochi, Japan .
authors.forename: Noriaki
authors.initials: N
authors.lastname: Abe
authors.affiliation: 1 Department of Pharmacy, Kochi Medical Graduate School , Kochi, Japan .|2 Department of Pharmacy, Kochi Medical School Hospital , Kochi, Japan .
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shiraishi
authors.affiliation: 1 Department of Pharmacy, Kochi Medical Graduate School , Kochi, Japan .|2 Department of Pharmacy, Kochi Medical School Hospital , Kochi, Japan .
authors.forename: Ayumu
authors.initials: A
authors.lastname: Hirata
authors.affiliation: 1 Department of Pharmacy, Kochi Medical Graduate School , Kochi, Japan .|2 Department of Pharmacy, Kochi Medical School Hospital , Kochi, Japan .
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yagi
authors.affiliation: 2 Department of Pharmacy, Kochi Medical School Hospital , Kochi, Japan .
authors.forename: Kohei
authors.initials: K
authors.lastname: Jobu
authors.affiliation: 2 Department of Pharmacy, Kochi Medical School Hospital , Kochi, Japan .
authors.forename: Junko
authors.initials: J
authors.lastname: Yokota
authors.affiliation: 4 Hosoda SHC Co., Ltd. , Fukui, Japan .
authors.forename: Eishin
authors.initials: E
authors.lastname: Kato
authors.affiliation: 4 Hosoda SHC Co., Ltd. , Fukui, Japan .
authors.forename: Shinya
authors.initials: S
authors.lastname: Hosoda
authors.affiliation: 3 Faculty of Pharmaceutical Sciences, Tokushima Bunri University , Tokushima, Japan .
authors.forename: Saburo
authors.initials: S
authors.lastname: Yoshioka
authors.affiliation: 3 Faculty of Pharmaceutical Sciences, Tokushima Bunri University , Tokushima, Japan .
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.affiliation: 3 Faculty of Pharmaceutical Sciences, Tokushima Bunri University , Tokushima, Japan .
authors.forename: Miwa
authors.initials: M
authors.lastname: Kubo
authors.affiliation: 3 Faculty of Pharmaceutical Sciences, Tokushima Bunri University , Tokushima, Japan .
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Fukuyama
authors.affiliation: 1 Department of Pharmacy, Kochi Medical Graduate School , Kochi, Japan .|2 Department of Pharmacy, Kochi Medical School Hospital , Kochi, Japan .
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Miyamura
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000523:psychology; D000818:Animals; D018891:Dentate Gyrus / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D051379:Mice; D008822:Mice, Transgenic; D055495:Neurogenesis / Q000187:drug effects*; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D065853:Spatial Learning / Q000187:drug effects*; D030521:Zingiberaceae / Q000737:chemistry*
keywords: Bangle (Zingiber purpureum); Ki67; SAMP8; neurogenesis; neurotrophic activity; spatial learning and memory