title: Brønsted acid-catalysed conjugate addition of photochemically generated α-amino radicals to alkenylpyridines.
abstract: The conjugate addition of α-amino radicals to alkenylpyridines has been accomplished by the synergistic merger of Brønsted acid and visible light photoredox catalysis. Key to reaction development was the protonation of the alkenylpyridines that transiently generated a highly reactive, electrophilic pseudo-iminium ion intermediate. Initial investigations using chiral phosphoric acids provide clues on the feasibility of an enantioselective catalytic variant.
authors.affiliation: ICIQ - Institute of Chemical Research of Catalonia, The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain. pmelchiorre@iciq.es.
authors.forename: Hamish B
authors.initials: HB
authors.lastname: Hepburn
authors.forename: Paolo
authors.initials: P
authors.lastname: Melchiorre
mesh_terms: D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D055668:Photochemical Processes; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000143:Acids; D011725:Pyridines