title: Stimuli-responsive supramolecular hydrogels with high extensibility and fast self-healing via precoordinated mussel-inspired chemistry.
abstract: Supramolecular hydrogels have the advantages of stimuli responsiveness and self-healing compared to covalently crosslinked hydrogels. However, the existing supramolecular hydrogels are usually poor in mechanical properties especially in extensibility. In addition, these supramolecular hydrogels need a long self-healing time and have low self-healing efficiency. In this manuscript, we report a novel strategy to develop highly extensible and fast self-healing supramolecular hydrogels by using pre-coordinated mussel-inspired catechol-Fe3+complexes as dynamic crosslinkers. The hydrogel can be fabricated and cast into various shapes by one-step photo-crosslinking. Thus fabricated hydrogels can be stretched beyond 10 times their original lengths, and the high extensibility can completely recover within a very short time (less than 20 minutes) even after the hydrogels are entirely cut apart. Utilizing the dynamic nature of supramolecular hydrogels, we can realize different mechanical behaviors including strength, extensibility and recoverability by varying the loading conditions. In addition, the hydrogels respond to multiple stimuli including mechanical force, temperature and certain chemicals because of the dynamic catechol-Fe3+bond.
authors.affiliation: Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710054, China; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109, USA.
authors.forename: Sen
authors.initials: S
authors.lastname: Hou
authors.affiliation: Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710054, China; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Peter X
authors.initials: PX
authors.lastname: Ma
references.citation: Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4383-8
references.pmid: 22392977
references.citation: Nature. 2007 Jul 19;448(7151):338-41
references.pmid: 17637666
references.citation: Science. 2012 Feb 17;335(6070):813-7
references.pmid: 22344437
references.citation: Nat Mater. 2007 Sep;6(9):669-72
references.pmid: 17618290
references.citation: Chem Soc Rev. 2012 Sep 21;41(18):6195-214
references.pmid: 22890548
references.citation: Nat Biotechnol. 2013 Jun;31(6):553-6
references.pmid: 23666011
references.citation: Adv Mater. 2013 May 28;25(20):2849-53
references.pmid: 23423947
references.citation: J Am Chem Soc. 2006 Sep 6;128(35):11663-72
references.pmid: 16939292
references.citation: J Am Chem Soc. 2010 Oct 13;132(40):14251-60
references.pmid: 20845973
references.citation: Adv Mater. 2014 Jun 4;26(21):3415-9
references.pmid: 24596273
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):12999-3003
references.pmid: 16920796
references.citation: Biomacromolecules. 2013 Feb 11;14(2):297-301
references.pmid: 23347052
references.citation: Chem Commun (Camb). 2011 Feb 7;47(5):1379-83
references.pmid: 20967393
references.citation: Adv Funct Mater. 2013 Mar 6;23(9):1111-1119
references.pmid: 23483665
references.citation: Nat Biotechnol. 2005 Jan;23(1):47-55
references.pmid: 15637621
references.citation: Science. 2010 Apr 9;328(5975):216-20
references.pmid: 20203014
references.citation: Adv Mater. 2011 May 24;23(20):2327-31
references.pmid: 21491513
references.citation: Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2651-5
references.pmid: 21278337
references.citation: Nat Mater. 2010 Feb;9(2):101-13
references.pmid: 20094081
references.citation: Adv Drug Deliv Rev. 2002 Jan 17;54(1):3-12
references.pmid: 11755703
references.citation: Chem Soc Rev. 2012 Sep 21;41(18):6042-65
references.pmid: 22618080
references.citation: Biomaterials. 2009 Dec;30(35):6702-7
references.pmid: 19783300
references.citation: Adv Mater. 2012 Jan 17;24(3):362-9
references.pmid: 22161963
references.citation: Adv Mater. 2012 May 22;24(20):2703-9
references.pmid: 22528786
references.citation: Adv Drug Deliv Rev. 2002 Jan 17;54(1):13-36
references.pmid: 11755704
references.citation: Biomaterials. 2001 Mar;22(6):511-21
references.pmid: 11219714
references.citation: Chem Rev. 1996 Nov 7;96(7):2239-2314
references.pmid: 11848828
references.citation: Biomaterials. 2006 Aug;27(22):4132-40
references.pmid: 16584769
references.citation: Nature. 2010 Jan 21;463(7279):339-43
references.pmid: 20090750