title: Evaluation of bone mineral density and 25-hydroxyvitamin D levels in subjects with silica exposure.
abstract: OBJECTIVE
  The purpose of the study was to evaluate the bone mineral density (BMD) and 25-hydroxyvitamin D (25(OH)D) levels in patients with silica exposure.
  
  
  METHODS
  The study included 104 male subjects with silica exposure and 36 healthy subjects. Posterior-anterior radiographs were classified according to the International Labour Office (ILO) Classification. Category 0 patients were classified as Group I (n = 54), category I patients were classified as Group II (n = 25), Category II and III patients were classified as Group III (n = 25).
  
  
  RESULTS
  Femoral neck BMD values were significantly lower in Group III (p = 0.007). Lumbar vertebrae BMD values were significantly lower in all groups with silica exposure than in the control group (p = 0.000). The osteoporosis rate was significantly higher in Group III (p = 0.000). Subjects with silica exposure were determined to have diminished 25(OH)D levels (p = 0.012).
  
  
  CONCLUSIONS
  The results of this study demonstrated that subjects with silica exposure have diminished BMD and 25(OH)D levels.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ankara Occupational Diseases Hospital, Ankara, Turkey. ftr.mustafaturgut@hotmail.com.
authors.forename: Mustafa Turgut
authors.initials: MT
authors.lastname: Yıldızgören
authors.affiliation: Department of Chest Diseases, Ankara Occupational Diseases Hospital, Ankara, Turkey.
authors.forename: Türkan Nadir
authors.initials: TN
authors.lastname: Öziş
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ankara Occupational Diseases Hospital, Ankara, Turkey.
authors.forename: Ali Erdem
authors.initials: AE
authors.lastname: Baki
authors.affiliation: Department of Toxicology, Ankara Occupational Diseases Hospital, Ankara, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Tutkun
authors.affiliation: Department of Toxicology, Ankara Occupational Diseases Hospital, Ankara, Turkey.
authors.forename: Hınç
authors.initials: H
authors.lastname: Yılmaz
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey.
authors.forename: Tülay
authors.initials: T
authors.lastname: Tiftik
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey.
authors.forename: Timur
authors.initials: T
authors.lastname: Ekiz
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey.
authors.forename: Neşe
authors.initials: N
authors.lastname: Özgirgin
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density / Q000187:drug effects*; D003430:Cross-Sectional Studies; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology; D012822:Silicon Dioxide / Q000633:toxicity*; D012829:Silicosis / Q000453:epidemiology* / Q000209:etiology; D014421:Turkey / Q000453:epidemiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; D012822:Silicon Dioxide; C104450:25-hydroxyvitamin D
keywords: Bone mineral density; Osteoporosis; Pneumoconiosis; Silicosis; Vitamin D
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