title: [Association of single nucleotide polymorphisms of IL-6 gene with longevity in Uyghurs in Xinjiang].
abstract: OBJECTIVE
  To investigate whether the variations of genes encoding pro-inflammatory cytokines is associated with longevity in Uyghurs in Xinjiang.
  
  
  METHODS
  A total of 240 individuals aged ≥90 years from Xinjiang Uyghur Autonomous Region were enrolled between 1999 and 2012 as the longevity group, 92 unrelated individuals from the same area who died naturally at the age of 59-73 in the same period were selected as the control group. Seven single nucleotide polymorphisms (SNPs) of 4 genes (tumor necrosis factor (TNF)-α(rs1800629), IL-6(rs1800796, rs10499563), C-reactive protein (CRP) (rs2808630, rs1205) and IL-1β(rs1143623, rs16944)) were genotyped. Logistic regression was applied to assess the association between each individual SNP and longevity in case-control analyses.
  
  
  RESULTS
  The distribution of C allele of rs1800796 in the longevity group (0.298) was lower than that in the control group (0.435) with statistical significance (P=0.001). The distributions of the other 6 genetic variations between the longevity group and the control group showed no statistically significant differences (all P>0.05). CT genotype of rs1800796 was positively associated with longevity (Padd=0.002, OR=1.983, 95%CI: 1.296-3.023), while no significant association was noted between other genotypes and longevity.
  
  
  CONCLUSIONS
  SNP of rs1800796 of IL-6 gene may be significantly associated with longevity in Uyghurs in Xinjiang. CT genotype of rs1800796 is significantly associated with longevity. C allele of rs1800796 may be a negative factor for longevity.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Mamuti
authors.initials: M
authors.lastname: Gulizibaer
authors.forename: Yao
authors.initials: Y
authors.lastname: Hu
authors.forename: Fenghui
authors.initials: F
authors.lastname: Chen
authors.forename: Huaixing
authors.initials: H
authors.lastname: Li
authors.forename: Zuheng
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Email: 1151486809@qq.com.
authors.forename: Wufuer
authors.initials: W
authors.lastname: Mayila
mesh_terms: D000368:Aged; D000483:Alleles; D002097:C-Reactive Protein; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta; D015850:Interleukin-6; D016015:Logistic Models; D008136:Longevity; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha
chemical_list: C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein