title: One of the most well-established age-related changes in neural activity disappears after controlling for visual acuity.
abstract: Numerous studies using a variety of imaging techniques have reported age-related differences in neural activity while subjects carry out cognitive tasks. Surprisingly little attention has been paid to the potential impact of age-associated changes in sensory acuity on these findings. Studies in the visual modality frequently report that their subjects had "normal or corrected- to-normal vision." However, in most cases, there is no indication that visual acuity was actually measured, and it is likely that the investigators relied largely on self-reported visual status of subjects, which is often inaccurate. We investigated whether differences in visual acuity influence one of the most commonly observed findings in the event-related potentials literature on cognitive aging, a reduction in posterior P3b amplitude, which is an index of cognitive decision-making/updating. Well-matched young (n=26) and old adults (n=29) participated in a visual oddball task. Measured visual acuity with corrective lenses was worse in old than young adults. Results demonstrated that the robust age-related decline in P3b amplitude to visual targets disappeared after controlling for visual acuity, but was unaffected by accounting for auditory acuity. Path analysis confirmed that the relationship between age and diminished P3b to visual targets was mediated by visual acuity, suggesting that conveyance of suboptimal sensory data due to peripheral, rather than central, deficits may undermine subsequent neural processing. We conclude that until the relationship between age-associated differences in visual acuity and neural activity during experimental tasks is clearly established, investigators should exercise caution attributing results to differences in cognitive processing.
authors.affiliation: Laboratory of Healthy Cognitive Aging, Division of Cognitive and Behavioral Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address: portofhg@gmail.com.
authors.forename: Fábio H G
authors.initials: FHG
authors.lastname: Porto
authors.affiliation: Laboratory of Healthy Cognitive Aging, Division of Cognitive and Behavioral Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address: etusch@partners.org.
authors.forename: Erich S
authors.initials: ES
authors.lastname: Tusch
authors.affiliation: Laboratory of Healthy Cognitive Aging, Division of Cognitive and Behavioral Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address: afox2014@gmail.com.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Fox
authors.affiliation: Laboratory of Healthy Cognitive Aging, Division of Cognitive and Behavioral Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address: alperinb@ohsu.edu.
authors.forename: Brittany R
authors.initials: BR
authors.lastname: Alperin
authors.affiliation: Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA. Electronic address: pholcomb@tufts.edu.
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Holcomb
authors.affiliation: Laboratory of Healthy Cognitive Aging, Division of Cognitive and Behavioral Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address: kdaffner@partners.org.
authors.forename: Kirk R
authors.initials: KR
authors.lastname: Daffner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003657:Decision Making / Q000502:physiology; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D025341:Principal Component Analysis; D012107:Research Design; D014792:Visual Acuity; D055815:Young Adult
keywords: Aging; ERPs; Neural activity; P3b; Visual acuity
references.citation: J Cogn Neurosci. 2015 Jul;27(7):1275-85
references.pmid: 25603025
references.citation: Psychol Aging. 1994 Sep;9(3):339-55
references.pmid: 7999320
references.citation: Vision Res. 2011 Jul 1;51(13):1610-22
references.pmid: 20974168
references.citation: J Cogn Neurosci. 2011 Jun;23(6):1298-314
references.pmid: 20617886
references.citation: Clin Neurophysiol. 2010 Sep;121(9):1464-1472
references.pmid: 20399706
references.citation: Nat Neurosci. 2000 May;3(5):509-15
references.pmid: 10769393
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: Neurobiol Aging. 2013 Feb;34(2):477-88
references.pmid: 22459599
references.citation: Electroencephalogr Clin Neurophysiol. 1997 May;104(3):244-56
references.pmid: 9186239
references.citation: Arch Clin Neuropsychol. 1992;7(2):135-43
references.pmid: 14589637
references.citation: J Clin Neurophysiol. 1992 Oct;9(4):456-79
references.pmid: 1464675
references.citation: Neuroimage. 2002 Nov;17(3):1394-402
references.pmid: 12414279
references.citation: J Neurosci. 2012 Feb 8;32(6):2154-8
references.pmid: 22323727
references.citation: Hum Brain Mapp. 1999;7(2):115-35
references.pmid: 9950069
references.citation: Nat Rev Neurosci. 2008 Jun;9(6):467-79
references.pmid: 18464792
references.citation: Psychophysiology. 1986 Jul;23(4):367-84
references.pmid: 3774922
references.citation: Electroencephalogr Clin Neurophysiol. 1985 Mar;62(2):141-9
references.pmid: 2578944
references.citation: Arch Ophthalmol. 1998 May;116(5):653-8
references.pmid: 9596502
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13122-6
references.pmid: 18765818
references.citation: Can J Exp Psychol. 2002 Sep;56(3):153-63
references.pmid: 12271746
references.citation: Prog Neurobiol. 2007 Dec;83(6):375-400
references.pmid: 17870229
references.citation: Arch Ophthalmol. 1970 Sep;84(3):272-8
references.pmid: 5457478
references.citation: Front Hum Neurosci. 2014 Apr 14;8:213
references.pmid: 24782741
references.citation: J Neurosci Methods. 2010 Mar 15;187(1):138-45
references.pmid: 20035787
references.citation: Neuroimage. 2008 Jan 1;39(1):441-54
references.pmid: 17931892
references.citation: Arch Ophthalmol. 1990 Feb;108(2):286-90
references.pmid: 2271016
references.citation: Brain. 1994 Oct;117 ( Pt 5):1055-71
references.pmid: 7953588
references.citation: Invest Ophthalmol Vis Sci. 1999 Apr;40(5):858-64
references.pmid: 10102282
references.citation: J Gerontol B Psychol Sci Soc Sci. 1996 Nov;51(6):P317-30
references.pmid: 8931619
references.citation: Biol Psychol. 2000 Oct;54(1-3):107-43
references.pmid: 11035221
references.citation: Psychol Aging. 2012 Sep;27(3):785-90
references.pmid: 22201330
references.citation: Psychophysiology. 1995 Nov;32(6):579-94
references.pmid: 8524992
references.citation: Psychophysiology. 2014 Jul;51(7):620-33
references.pmid: 24660980
references.citation: Psychol Aging. 2001 Dec;16(4):588-99
references.pmid: 11766914
references.citation: Neuroimage. 2013 Feb 15;67:127-36
references.pmid: 23153966
references.citation: Nat Neurosci. 2012 Dec;15(12):1729-35
references.pmid: 23103963
references.citation: Psychophysiology. 1981 Sep;18(5):493-513
references.pmid: 7280146
references.citation: PLoS One. 2014 Feb 13;9(2):e87347
references.pmid: 24551055
references.citation: Psychol Aging. 2006 Mar;21(1):7-18
references.pmid: 16594787
references.citation: Dev Neuropsychol. 2012;37(6):497-517
references.pmid: 22889342
references.citation: Clin Neuropsychol. 2003 May;17(2):129-36
references.pmid: 13680419
references.citation: Neurobiol Aging. 2012 Oct;33(10):2448-61
references.pmid: 22277263
references.citation: Hum Brain Mapp. 2007 Aug;28(8):742-63
references.pmid: 17133395
references.citation: Doc Ophthalmol. 2015 Oct;131(2):137-48
references.pmid: 25976745
references.citation: Psychol Aging. 2002 Mar;17(1):24-43
references.pmid: 11931285
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2181-6
references.pmid: 18238903
references.citation: J Psychiatr Res. 1982-1983;17(1):37-49
references.pmid: 7183759
references.citation: Psychophysiology. 1998 Sep;35(5):508-20
references.pmid: 9715095
references.citation: Neuropsychobiology. 1998;37(1):20-7
references.pmid: 9438268
references.citation: Brain. 1998 Jun;121 ( Pt 6):1013-52
references.pmid: 9648540
references.citation: Psychol Aging. 1997 Mar;12(1):12-21
references.pmid: 9100264
references.citation: Ophthalmology. 2008 May;115(5):808-814.e1
references.pmid: 17900695
references.citation: Cortex. 2007 Oct;43(7):952-66
references.pmid: 17941352
references.citation: Cortex. 2010 Apr;46(4):421-4
references.pmid: 20132931
references.citation: Psychophysiology. 1998 Nov;35(6):698-708
references.pmid: 9844431
references.citation: Trends Neurosci. 2004 Mar;27(3):161-8
references.pmid: 15036882
references.citation: Cereb Cortex. 2004 Feb;14(2):143-55
references.pmid: 14704211
references.citation: Cereb Cortex. 2005 Apr;15(4):394-402
references.pmid: 15749983
references.citation: Cereb Cortex. 2008 May;18(5):1201-9
references.pmid: 17925295
references.citation: Psychol Aging. 2002 Mar;17(1):56-71
references.pmid: 11931287
references.citation: Neuron. 2002 Feb 28;33(5):827-40
references.pmid: 11879658
references.citation: J Cogn Neurosci. 2000 Jan;12(1):174-87
references.pmid: 10769314
references.citation: J Neurosci Methods. 2004 Mar 15;134(1):9-21
references.pmid: 15102499
references.citation: Psychiatr Q. 1995 Winter;66(4):357-70
references.pmid: 8584591