title: Interaction between MLL3 genetic polymorphisms, smoking, and alcohol drinking in laryngeal cancer: a case-control study.
abstract: A previous study indicated that MLL3 genetic polymorphisms were associated with human cancer. However, whether MLL3 genetic variants are associated with the risk of laryngeal cancer is not clear. This study investigated the association between MLL3 gene polymorphisms and laryngeal cancer in a Chinese population. Four polymorphisms of the MLL3 gene (rs6943984, rs4725443, rs3800836, rs6464211) were genotyped using the TaqMan method in 592 patients with larynx cancer and 602 age- and sex-matched noncancer controls. We found that rs6943984 and rs4725443 of the MLL3 gene were significantly associated with the risk of larynx cancer after Bonferroni correction. The minor allele A for rs6943984 was associated with increased larynx cancer risk (P < 0.001, OR = 1.960, 95% CI = 1.587-2.420). C allele frequency (0.151) for rs4725443 was significantly higher in the case group than the control group (0.072, P < 0.001). Haplotype analyses showed that haplotypes A-T-A-C and G-T-G-C increased the risk of laryngeal cancer (OR = 2.406, 95% CI: 1.820-3.180, P < 0.001; OR = 1.399, 95% CI: 1.180-1.659, respectively), and haplotypes G-T-A-C and G-T-G-T significantly reduced the risk of laryngeal cancer (OR = 0.332, 95% CI: 0.271-0.408, P < 0.001; OR = 0.742, 95% CI: 0.607-0.908, respectively). We also found that MLL3 rs6943984 and rs4725443 polymorphisms had synergistic effects with smoking or alcohol drinking for the risk of laryngeal cancer. This study indicated that MLL3 genetic polymorphisms and haplotypes were associated with larynx cancer in a Chinese population. There was a mutually synergistic effect between smoking, alcohol drinking, and MLL3 gene polymorphisms for laryngeal cancer.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The first Affiliated Hospital of Liaoning Medical University, No. 2, Section 5, Renmin Street, Guta District, Jinzhou, Liaoning, 121001, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The first Affiliated Hospital of Liaoning Medical University, No. 2, Section 5, Renmin Street, Guta District, Jinzhou, Liaoning, 121001, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Gong
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The first Affiliated Hospital of Liaoning Medical University, No. 2, Section 5, Renmin Street, Guta District, Jinzhou, Liaoning, 121001, China.
authors.forename: Qichuan
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The first Affiliated Hospital of Liaoning Medical University, No. 2, Section 5, Renmin Street, Guta District, Jinzhou, Liaoning, 121001, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Stomatology, The First Affiliated Hospital of Liaoning Medical University, No. 2, Section 5, Renmin Street, Guta District, Jinzhou, Liaoning, 121001, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C452979:KMT2C protein, human
keywords: Haplotype; MLL3; laryngeal cancer; polymorphism
references.citation: J BUON. 2014 Apr-Jun;19(2):394-7
references.pmid: 24965397
references.citation: Cell Res. 2009 Apr;19(4):519-23
references.pmid: 19290020
references.citation: Gene. 2002 Feb 6;284(1-2):73-81
references.pmid: 11891048
references.citation: Cell Res. 2005 Feb;15(2):97-8
references.pmid: 15740637
references.citation: Tumour Biol. 2014 May;35(5):4659-65
references.pmid: 24563277
references.citation: BMC Cancer. 2014 Jun 10;14:420
references.pmid: 24917392
references.citation: J Laryngol Otol. 2006 Mar;120(3):170-7
references.pmid: 16372991
references.citation: Blood. 1998 Dec 1;92(11):4031-5
references.pmid: 9834205
references.citation: Proc Nutr Soc. 2004 Feb;63(1):65-71
references.pmid: 15070439
references.citation: Clin Appl Thromb Hemost. 2009 Oct;15(5):574-80
references.pmid: 19147528
references.citation: Asian Pac J Cancer Prev. 2014;15(14):5681-4
references.pmid: 25081685
references.citation: Tumour Biol. 2014 Jun;35(6):5427-30
references.pmid: 24523020
references.citation: Cancer Res. 2007 Apr 15;67(8):3545-50
references.pmid: 17440062
references.citation: Arch Med Sci. 2012 Dec 20;8(6):1065-75
references.pmid: 23319983
references.citation: Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9737-41
references.pmid: 7568208
references.citation: Cancer Med. 2016 Mar;5(3):527-33
references.pmid: 26818916
references.citation: Proc Natl Acad Sci U S A. 2009 May 26;106(21):8513-8
references.pmid: 19433796
references.citation: Hippokratia. 2013 Oct;17(4):313-8
references.pmid: 25031508
references.citation: Tumour Biol. 2014 Mar;35(3):2669-73
references.pmid: 24213927
references.citation: Eur J Cancer Prev. 2008 Apr;17(2):116-24
references.pmid: 18287868
references.citation: Blood. 2013 Feb 21;121(8):1478-9
references.pmid: 23429989
references.citation: Science. 2011 Jan 28;331(6016):435-9
references.pmid: 21163964
references.citation: PLoS One. 2011;6(8):e23320
references.pmid: 21853109
references.citation: Gene. 2014 May 25;542(1):64-8
references.pmid: 24582975
references.citation: Asian Pac J Cancer Prev. 2013;14(7):4239-42
references.pmid: 23991983
references.citation: Cancer. 2014 Jul 15;120(14):2191-8
references.pmid: 24866103
references.citation: Pathol Oncol Res. 2011 Jun;17(2):429-33
references.pmid: 21116761
references.citation: Cancer Genet Cytogenet. 2009 Mar;189(2):140-1
references.pmid: 19215798
references.citation: Am J Clin Nutr. 2014 Mar;99(3):559-66
references.pmid: 24401718
references.citation: Br J Cancer. 2004 Oct 18;91(8):1543-50
references.pmid: 15365572