title: Recent Strategies Combining Biomaterials and Stem Cells for Bone, Liver and Skin Regeneration.
abstract: This review is focused on the combination of biomaterials with stem cells as a promising strategy for bone, liver and skin regeneration. At first, we describe stem cell-based constructs for bone tissue engineering with special attention to recent advanced approaches based on the use of biomaterial scaffolds with renewable stem cells that have been used for bone regeneration. We illustrate the strategies to improve liver regeneration by using liver stem cells and biomaterials and/or devices as therapeutic approaches. In particular, examples of biomaterials in combination with other technologies are presented since they allow the differentiation of stem cells in hepatocytes. After a description of the role and the benefit of MSCs in wound repair and in skin substitutes we highlight the suitability of biomaterials in guiding stem cell differentiation for skin regeneration and cutaneous repair in both chronic and acute wounds. Finally, an overview of the types of bioreactors that have been developed for the differentiation of stem cells and are currently in use, is also provided. The examples of engineered microenvironments reported in this review indicate that a detailed understanding of the various factors and mechanisms that control the behavior of stem cells in vivo has provided useful information for the development of advanced bioartificial systems able to control cell fate.
authors.affiliation: Institute on Membrane Technology, National Research Council of Italy, Via P. Bucci, Cubo 17/C, 87036 Rende (CS), Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Morelli
authors.forename: Simona
authors.initials: S
authors.lastname: Salerno
authors.forename: Haysam Mohamed Magdy
authors.initials: HM
authors.lastname: Ahmed
authors.forename: Antonella
authors.initials: A
authors.lastname: Piscioneri
authors.forename: Loredana De
authors.initials: L
authors.lastname: Bartolo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008115:Liver Regeneration / Q000187:drug effects / Q000502:physiology*; D012867:Skin / Q000166:cytology* / Q000187:drug effects; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials