title: [Immune response to Mycobacterium tuberculosis].
abstract: Infections with Mycobacterium tuberculosis (MTB) induce complex immune responses involving an orchestrated interplay of innate and adaptive immune mechanisms. Why the immune system fails to eradicate the pathogen and at best achieves control of infection in the latent stage, still remains an unsolved mystery even more than 100 years after the discovery of MTB by Robert Koch. This article provides an overview of the current state of the art in the constantly evolving field of tuberculosis (TB) immunology. This review focuses on a change of paradigm proposing that in the latent stage MTB is anything but dormant and that latent TB is not merely a state of bacterial stasis but a state of dynamic bacterial and immunological equilibrium. The understanding of these dynamics is crucial for the development of new drugs against MTB as well as vaccines that aim to provide effective protection against the disease.
authors.affiliation: Klinik I für Innere Medizin, Uniklinik Köln, Gleueler Str. 129-131, Gebäude 57, 50937, Köln, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Nowag
authors.affiliation: Klinik I für Innere Medizin, Uniklinik Köln, Gleueler Str. 129-131, Gebäude 57, 50937, Köln, Deutschland. pia.hartmann@uk-koeln.de.|Zentrale Krankenhaushygiene, Uniklinik Köln, Gleueler Str. 129-131, Gebäude 57, 50937, Köln, Deutschland. pia.hartmann@uk-koeln.de.
authors.forename: P
authors.initials: P
authors.lastname: Hartmann
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D055985:Latent Tuberculosis / Q000276:immunology* / Q000382:microbiology*; D018448:Models, Immunological; D009169:Mycobacterium tuberculosis / Q000276:immunology*
keywords: Cytokines; Immunity, adaptive; Immunity, innate; Latent tuberculosis; Tumor necrosis factor alpha
references.citation: Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15594-8
references.pmid: 17028173
references.citation: Blood. 2010 Nov 4;116(18):3485-93
references.pmid: 20656932
references.citation: J Immunol. 2006 Mar 1;176(5):3019-27
references.pmid: 16493060
references.citation: J Immunol. 2011 Jun 15;186(12):7110-9
references.pmid: 21555529
references.citation: Annu Rev Immunol. 2001;19:93-129
references.pmid: 11244032
references.citation: Mucosal Immunol. 2011 May;4(3):252-60
references.pmid: 21430655
references.citation: Mucosal Immunol. 2011 May;4(3):288-93
references.pmid: 21451503
references.citation: Annu Rev Microbiol. 2010;64:293-311
references.pmid: 20825351
references.citation: Lab Invest. 1999 Apr;79(4):379-86
references.pmid: 10211990
references.citation: Infect Immun. 2006 May;74(5):2985-95
references.pmid: 16622237
references.citation: Cell. 2009 Jan 9;136(1):37-49
references.pmid: 19135887
references.citation: Nat Rev Immunol. 2010 Mar;10(3):170-81
references.pmid: 20154735
references.citation: J Immunol. 2010 Mar 15;184(6):2756-60
references.pmid: 20164423
references.citation: J Immunol. 2005 Apr 1;174(7):4185-92
references.pmid: 15778379
references.citation: PLoS Pathog. 2011 May;7(5):e1002063
references.pmid: 21637811
references.citation: J Exp Med. 2003 Jan 6;197(1):121-7
references.pmid: 12515819
references.citation: J Immunol. 2010 Jun 15;184(12):7057-70
references.pmid: 20488784
references.citation: J Exp Med. 2010 Jul 5;207(7):1409-20
references.pmid: 20547826
references.citation: Eur J Immunol. 2011 Jul;41(7):1941-7
references.pmid: 21509782
references.citation: Clin Infect Dis. 2003 Jan 1;36(1):24-8
references.pmid: 12491197
references.citation: J Immunol. 2007 Sep 15;179(6):3463-71
references.pmid: 17785780
references.citation: Science. 2004 Jan 23;303(5657):527-31
references.pmid: 14739458
references.citation: Clin Exp Immunol. 1999 Jan;115(1):110-3
references.pmid: 9933428
references.citation: Annu Rev Immunol. 2004;22:817-90
references.pmid: 15032598
references.citation: Annu Rev Immunol. 1992;10:411-52
references.pmid: 1590993
references.citation: Infect Immun. 2008 Sep;76(9):4269-81
references.pmid: 18591237
references.citation: Annu Rev Immunol. 2004;22:599-623
references.pmid: 15032590
references.citation: J Exp Med. 2009 Sep 28;206(10):2205-20
references.pmid: 19770268
references.citation: Arthritis Rheum. 2010 Feb;62(2):340-50
references.pmid: 20112395
references.citation: Cell Host Microbe. 2012 Jan 19;11(1):81-90
references.pmid: 22264515
references.citation: Nat Genet. 2011 May;43(5):482-6
references.pmid: 21516081
references.citation: Clin Vaccine Immunol. 2009 Aug;16(8):1203-12
references.pmid: 19553548
references.citation: Clin Exp Immunol. 2010 Jul 1;161(1):1-9
references.pmid: 20491796
references.citation: N Engl J Med. 2001 Oct 11;345(15):1098-104
references.pmid: 11596589
references.citation: J Biol Chem. 2008 Jun 27;283(26):18032-9
references.pmid: 18400743
references.citation: J Infect Dis. 2003 Oct 1;188(7):1032-9
references.pmid: 14513424
references.citation: J Exp Med. 2011 Aug 29;208(9):1741-7
references.pmid: 21807869
references.citation: Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):270-5
references.pmid: 9419365
references.citation: Nat Med. 2009 Feb;15(2):211-4
references.pmid: 19182798
references.citation: Clin Microbiol Rev. 2011 Apr;24(2):351-76
references.pmid: 21482729
references.citation: Immunity. 2011 Dec 23;35(6):1023-34
references.pmid: 22195750
references.citation: J Exp Med. 2003 Sep 1;198(5):705-13
references.pmid: 12953092
references.citation: Annu Rev Immunol. 2013;31:475-527
references.pmid: 23516984
references.citation: Nat Rev Immunol. 2012 Jul 13;12(8):581-91
references.pmid: 22790178
references.citation: Cell Microbiol. 2011 Mar;13(3):402-18
references.pmid: 21040358
references.citation: Eur J Immunol. 2010 Aug;40(8):2200-10
references.pmid: 20518032
references.citation: Int J Tuberc Lung Dis. 2003 Oct;7(10):912-9
references.pmid: 14552560
references.citation: J Exp Med. 2009 Dec 21;206(13):2879-88
references.pmid: 20008526
references.citation: Nat Rev Immunol. 2005 Jun;5(6):485-96
references.pmid: 15928680
references.citation: J Exp Med. 2006 Jul 10;203(7):1805-15
references.pmid: 16818672
references.citation: Eur J Immunol. 2008 Mar;38(3):680-94
references.pmid: 18266299
references.citation: Mucosal Immunol. 2011 May;4(3):279-87
references.pmid: 21307848
references.citation: J Exp Med. 2005 Dec 19;202(12):1715-24
references.pmid: 16365150
references.citation: Trends Microbiol. 2002 May;10(5):221-6
references.pmid: 11973155
references.citation: Microbes Infect. 2011 Feb;13(2):198-201
references.pmid: 21034845
references.citation: Cell Microbiol. 2010 Aug;12 (8):1046-63
references.pmid: 20148899
references.citation: Infect Immun. 2004 Apr;72(4):2420-4
references.pmid: 15039373
references.citation: Arthritis Rheum. 2006 Feb 15;55(1):19-26
references.pmid: 16463407
references.citation: J Exp Med. 2008 Sep 29;205(10):2359-68
references.pmid: 18779346
references.citation: Immunology. 2006 Jun;118(2):195-201
references.pmid: 16771854
references.citation: J Infect Dis. 1993 Jun;167(6):1481-97
references.pmid: 8501346
references.citation: Vaccine. 2010 Dec 10;29(1):51-7
references.pmid: 20974305
references.citation: Annu Rev Immunol. 2009;27:393-422
references.pmid: 19302046
references.citation: J Exp Med. 1997 Jul 7;186(1):39-45
references.pmid: 9206995
references.citation: J Immunol. 2008 Nov 15;181(10):7157-65
references.pmid: 18981137
references.citation: Int J Tuberc Lung Dis. 2002 Aug;6(8):720-7
references.pmid: 12150485
references.citation: Mucosal Immunol. 2011 May;4(3):261-70
references.pmid: 21451501