title: [MECHANISMS OF MODULATION OF REFLEX CONTROL OF BREATHING AT ELEVATED SYSTEMIC LEVEL OF PROINFLAMMATORY CYTOKINE INTERLEUKIN-1β].
abstract: This study explores the hypothesis about the possible involvement of the cyclooxygenase pathway in the effects of interleukin-1beta (IL-1β) on the breathing pattern and Heuring-Breuer respiratory reflexes. Respiratory frequency (fR), tidal volume (VT) and esophageal pressure were recorded in 29 adult male Wistar rats anaesthetized with urethane. Heuring-Breuer reflexes were tested by airway occlusion at achieving functional residual capacity (inspiratory-inhibitory reflex), and at the height of inspiration (expiratory-promoting reflex). It had been shown that an elevation of IL-1β in the systemic circulation causes an increase in VT, fR, lung ventilation and strengthens respiratory reflexes. These respiratory effects had not been shown if IL-1β administered after intraperitoneal injection of diclofenac, which had not any significant respiratory effects by itself. Because diclofenac is a non-specific antagonist of cyclooxygenases, it had been concluded that the prostaglandins mediate respiratory effects of IL-1β in point of fact.
authors.forename: N P
authors.initials: NP
authors.lastname: Aleksandrova
authors.forename: V A
authors.initials: VA
authors.lastname: Merkuriev
authors.forename: T S
authors.initials: TS
authors.lastname: Tumanova
authors.forename: V G
authors.initials: VG
authors.lastname: Aleksandrov
mesh_terms: D000768:Anesthesia, General; D018686:Anesthetics, Intravenous; D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D053583:Interleukin-1beta / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D012119:Respiration / Q000187:drug effects*; D056152:Respiratory Rate / Q000187:drug effects / Q000502:physiology; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism; D013990:Tidal Volume / Q000187:drug effects / Q000502:physiology; D014520:Urethane
chemical_list: D018686:Anesthetics, Intravenous; D016861:Cyclooxygenase Inhibitors; D053583:Interleukin-1beta; D011453:Prostaglandins; D004008:Diclofenac; D014520:Urethane; D011451:Prostaglandin-Endoperoxide Synthases