title: Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction.
abstract: Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H2 O2 in a tumor microenvironment: Ionization of the AFeNPs enables on-demand ferrous ion release in the tumor, and subsequent H2 O2 disproportionation leads to efficient (.)OH generation. The endogenous stimuli-responsive (.)OH generation in the presence AFeNPs enables a highly specific cancer therapy without the need for external energy input.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai, 200050, P. R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai, 200050, P. R. China. wbbu@mail.sic.ac.cn.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Bu
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai, 200050, P. R. China.
authors.forename: Dalong
authors.initials: D
authors.lastname: Ni
authors.affiliation: Department of Radiology, Shanghai Cancer Hospital, Fudan University, 270 Dong-an Road, Shanghai, 200032, P. R. China.
authors.forename: Shenjian
authors.initials: S
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai, 200050, P. R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, 12 Urumqizhong Road, Shanghai, 200040, P. R. China.
authors.forename: Zhenwei
authors.initials: Z
authors.lastname: Yao
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, 12 Urumqizhong Road, Shanghai, 200040, P. R. China.
authors.forename: Jiawen
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai, 200050, P. R. China.
authors.forename: Heliang
authors.initials: H
authors.lastname: Yao
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai, 200050, P. R. China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai, 200050, P. R. China. jlshi@mail.sic.ac.cn.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005898:Glass / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000737:chemistry*; D058085:Iron Compounds / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use*; D061986:MCF-7 Cells; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D049329:Nanostructures / Q000737:chemistry* / Q000627:therapeutic use*; D010316:Particle Size; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013696:Temperature; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents; C045076:Fenton's reagent; D058085:Iron Compounds; D006861:Hydrogen Peroxide; D007501:Iron
keywords: Fenton reaction; antitumor agents; cancer; iron nanoparticles; magnetic resonance imaging