title: Metronidazole-Induced Bullous Pemphigoid: A Case Report.
abstract: Bullous pemphigoid is an autoimmune cutaneous blistering disorder, the exact pathogenesis of which is still not fully elucidated. Drug-induced bullous pemphigoid eruptions are rare but have been reported earlier with the use of frusemide, psoralens, ibuprofen, galantamine hydrobromide, ACE inhibitors like captopril, spironolactone, penicillin, ampicillin, levofloxacin, penicillamine. We hereby report a case of metronidazole induced bullous pemphigoid (BP) in a 52-year-old male patient suffering from liver abscess following 4 days of drug administration. The skin biopsy findings obtained from the patient were consistent with the diagnosis of bullous pemphigoid (BP). Metronidazole was discontinued and symptomatic treatment was offered to the patient. Following withdrawal of metronidazole, the bullae subsided in the next 7-10 days without any significant residual scarring. The causality assessment performed as per the Naranjo algorithm revealed the case to be probable (Naranjo score 7).
authors.affiliation: Pulmonologist, Department of Pulmonary Medicine, Charnock Hospital & Research Centre Pvt. Ltd. , Kolkata, West Bengal, India .
authors.forename: Saibal
authors.initials: S
authors.lastname: Moitra
authors.affiliation: Associate Professor, Department of Pharmacology, ICARE Institute of Medical Sciences & Research , Haldia, West Bengal, India .
authors.forename: Sukanta
authors.initials: S
authors.lastname: Sen
authors.affiliation: Assistant Professor, Department of Pharmacology, Lady Hardinge Medical College , New Delhi, India .
authors.forename: Indranil
authors.initials: I
authors.lastname: Banerjee
authors.affiliation: ICU Registrar, Department of Emergency Medicine, Chittaranjan Seva Sadan , Bhawanipur, Kolkata, West Bengal, India .
authors.forename: Ayan
authors.initials: A
authors.lastname: Sikder
authors.affiliation: Respiratory Therapist, Department of Pulmonary Medicine, Charnock Hospital & Research Centre Pvt. Ltd. , Kolkata, West Bengal, India .
authors.forename: Prasanta
authors.initials: P
authors.lastname: Das
keywords: Adverse drug reaction; Cutaneous drug eruptions; Drug-induced bullous pemphigoid
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