title: Three new 2,5-diketopiperazines from the fish intestinal Streptomyces sp. MNU FJ-36.
abstract: The gut actinobacteria of marine-inhabited fish is one of the most important reservoirs of novel natural products. Currently, the Streptomyces sp. MNU FJ-36 was isolated from the intestinal fabric of Katsuwonus sp. and determined by 16S rRNA analysis. From the cultures of the S. sp. MNU FJ-36, three new 2,5-diketopiperazines (2,5-DKPs) were discovered and identified as 3-(3-hydroxy-4-methoxybenzyl)-6-isobutyl-2,5-diketopiperazine (1), 3-(1,3-benzodioxol-5-ylmethyl)-6-isobutyl-2,5-diketopiperazine (2) and 3-(1,3-benzodioxol-5-ylmethyl)-6-isopropyl-2,5-diketopiperazine (3). Their structures were elucidated on the basis of spectroscopic data analysis. All the compounds were also evaluated for their inhibitory activity against P388, A-549 and HCT-116 cell lines with the MTT assay.
authors.affiliation: a Engineering Technological Center of Mushroom Industry , Minnan Normal University , Zhangzhou , P.R. China.|b College of Life Sciences and Technology , Minnan Normal University , Zhangzhou , P.R. China.
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Ou
authors.affiliation: a Engineering Technological Center of Mushroom Industry , Minnan Normal University , Zhangzhou , P.R. China.|b College of Life Sciences and Technology , Minnan Normal University , Zhangzhou , P.R. China.
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Huang
authors.affiliation: a Engineering Technological Center of Mushroom Industry , Minnan Normal University , Zhangzhou , P.R. China.|b College of Life Sciences and Technology , Minnan Normal University , Zhangzhou , P.R. China.
authors.forename: Xiu-Min
authors.initials: XM
authors.lastname: Li
authors.affiliation: c State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology , Shanghai Jiao Tong University , Shanghai , P.R. China.|d Joint International Research Laboratory of Metabolic & Developmental Sciences , Shanghai Jiao Tong University , Shanghai , P.R. China.
authors.forename: Qian-Jin
authors.initials: QJ
authors.lastname: Kang
authors.affiliation: a Engineering Technological Center of Mushroom Industry , Minnan Normal University , Zhangzhou , P.R. China.|b College of Life Sciences and Technology , Minnan Normal University , Zhangzhou , P.R. China.
authors.forename: Yu-Tian
authors.initials: YT
authors.lastname: Pan
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005399:Fishes / Q000382:microbiology*; D007422:Intestines / Q000382:microbiology; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D054659:Diketopiperazines
keywords: Intestinal Streptomyces; cyclodipeptide; cytotoxicity; diketopiperazine