title: Mechanical and biological properties of photocurable oligolactide-HA composites investigated under accelerated degradation.
abstract: The major concern related to biodegradable bone substitute materials is the loss of mechanical strength which can be undesirable when occurring too quickly before new bone formation. In this study, the multifunctional lactide oligomers having 2, 3, and 4 arms end capped with methacrylate groups were synthesized with the aim of improving the degradation properties. Their composites with hydroxyapatite (HA) were photopolymerized and subjected to accelerated degradation at 60 °C. The results showed that increasing number of arms significantly improved thermal and mechanical properties as well as biocompatibility of the composites. All composites although varying in number of arms had similar levels of bone-specific gene expression and calcification indicating their equal bioactivity in supporting bone formation. The high HA content in the composites was proposed to be responsible for enhanced osteoblast response, and this tended to suppress the effects of polymeric structure.
authors.affiliation: a Biomedical Engineering Research Unit , National Metal and Materials Technology Center , Pathumthani , Thailand.
authors.forename: Somruethai
authors.initials: S
authors.lastname: Channasanon
authors.affiliation: a Biomedical Engineering Research Unit , National Metal and Materials Technology Center , Pathumthani , Thailand.
authors.forename: Pakkanun
authors.initials: P
authors.lastname: Kaewkong
authors.affiliation: a Biomedical Engineering Research Unit , National Metal and Materials Technology Center , Pathumthani , Thailand.
authors.forename: Paweena
authors.initials: P
authors.lastname: Uppanan
authors.affiliation: a Biomedical Engineering Research Unit , National Metal and Materials Technology Center , Pathumthani , Thailand.
authors.forename: Siriporn
authors.initials: S
authors.lastname: Tanodekaew
mesh_terms: D016475:3T3 Cells; D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry* / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D004355:Drug Stability; D017886:Durapatite / Q000737:chemistry*; D007700:Kinetics; D055595:Mechanical Phenomena; D051379:Mice; D055668:Photochemical Processes; D011091:Polyesters / Q000737:chemistry*; D013696:Temperature
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; C033616:poly(lactide); D017886:Durapatite
keywords: Oligolactide; bioactivity; degradation; hydroxyapatite; mechanical property