title: Balance between Hyperinflammation and Immunosuppression in Sepsis.
abstract: Sepsis is a major cause of morbidity and mortality among hospitalized patients and the leading cause of death among patients admitted to intensive care units. The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways. These pathways are concurrent, starting early in the course of sepsis. Given the high burden of morbidity and mortality associated with sepsis, there is an increasing interest in immunomodulatory therapies targeted at improving outcomes in sepsis. This review will summarize current understanding about the balance between hyperinflammation and immunosuppression in sepsis and discuss the role of potential therapies to modulate these responses.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Hemang
authors.initials: H
authors.lastname: Yadav
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cartin-Ceba
mesh_terms: D003422:Critical Care; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007167:Immunotherapy / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D018805:Sepsis / Q000209:etiology* / Q000628:therapy*
chemical_list: D005938:Glucocorticoids