title: Factors Influencing Intraocular Pressure Changes after Laser In Situ Keratomileusis with Flaps Created by Femtosecond Laser or Mechanical Microkeratome.
abstract: The aim of this study is to describe factors that influence the measured intraocular pressure (IOP) change and to develop a predictive model after myopic laser in situ keratomileusis (LASIK) with a femtosecond (FS) laser or a microkeratome (MK). We retrospectively reviewed preoperative, intraoperative, and 12-month postoperative medical records in 2485 eyes of 1309 patients who underwent LASIK with an FS laser or an MK for myopia and myopic astigmatism. Data were extracted, such as preoperative age, sex, IOP, manifest spherical equivalent (MSE), central corneal keratometry (CCK), central corneal thickness (CCT), and intended flap thickness and postoperative IOP (postIOP) at 1, 6 and 12 months. Linear mixed model (LMM) and multivariate linear regression (MLR) method were used for data analysis. In both models, the preoperative CCT and ablation depth had significant effects on predicting IOP changes in the FS and MK groups. The intended flap thickness was a significant predictor only in the FS laser group (P < .0001 in both models). In the FS group, LMM and MLR could respectively explain 47.00% and 18.91% of the variation of postoperative IOP underestimation (R2 = 0.47 and R(2) = 0.1891). In the MK group, LMM and MLR could explain 37.79% and 19.13% of the variation of IOP underestimation (R(2) = 0.3779 and 0.1913 respectively). The best-fit model for prediction of IOP changes was the LMM in LASIK with an FS laser.
authors.affiliation: Department of Ophthalmology, Shuang Ho Hospital, Taipei Medical School of Medicine, Taipei Medical University, Taipei County, Taiwan.|Institute of Clinical Medicine, School of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Meng-Yin
authors.initials: MY
authors.lastname: Lin
authors.affiliation: Nobel Eye Clinic, Taipei, Taiwan.
authors.forename: David C K
authors.initials: DC
authors.lastname: Chang
authors.affiliation: Department of Ophthalmology, Shuang Ho Hospital, Taipei Medical School of Medicine, Taipei Medical University, Taipei County, Taiwan.
authors.forename: Yun-Dun
authors.initials: YD
authors.lastname: Shen
authors.affiliation: Biostatistics Center, Taipei Medical University, Taipei, Taiwan.
authors.forename: Yen-Kuang
authors.initials: YK
authors.lastname: Lin
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chang-Ping
authors.initials: CP
authors.lastname: Lin
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.|Institute of Clinical Medicine, School of Medicine, China Medical University, Taichung, Taiwan.
authors.forename: I-Jong
authors.initials: IJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation / Q000601:surgery*; D063171:Corneal Pachymetry; D003319:Corneal Stroma / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D019573:Epithelium, Corneal / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D020731:Keratomileusis, Laser In Situ / Q000534:rehabilitation*; D053685:Laser Therapy; D054018:Lasers, Excimer; D008297:Male; D008867:Microtomy / Q000295:instrumentation; D009216:Myopia / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation / Q000601:surgery*; D011184:Postoperative Period; D012044:Regression Analysis; D012189:Retrospective Studies; D013524:Surgical Flaps / Q000098:blood supply / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology
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