title: Left ventricular volumes by echocardiography in chronic aortic and mitral regurgitations.
abstract: Objectives Cut-off values for left ventricular (LV) dimensions indicating severe valve regurgitation have not been defined. The aim of this study was to establish echocardiographic cut-off values for LV dimensions indicating severe chronic aortic (AR) or mitral (MR) regurgitation. Design The hemodynamic significance was confirmed by documented reduction of end-diastolic volume (EDV) and symptom relief after surgery. Eighty-three patients with moderate or severe regurgitation (AR, n = 41; MR, n = 42) without other cardiac conditions underwent prospectively two-dimensional (2DE), real-time three-dimensional (RT3DE) echocardiography and cardiovascular magnetic resonance (CMR) exams within 4 h. Results The relationship between EDVCMR and EDV2DE and EDVRT3DE were strong (R 0.95 and 0.91). EDV index cut-offs for 2DE/RT3DE >87/104 ml/m(2) identified AR patients with severe regurgitation with a positive likelihood ratio (PLR) of 5.0/5.0. The corresponding in patients with MR EDV index cut-offs were >69/87 ml/m(2) with a PLR of 14.9/5.5. LV linear dimensions could not identify patients with severe regurgitation. Conclusions LV volumes by echocardiography can support the diagnosis of severe chronic regurgitation. Importantly, other causes for LV enlargement have to be considered.
authors.affiliation: a Department of Cardiology , Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;|b Department of Clinical Physiology , Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;|c Sahlgrenska University Hospital, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;|d Heart Centre, King Faisal Specialist Hospital & Research Centre , Riyadh , Kingdom of Saudi Arabia ;
authors.forename: Odd
authors.initials: O
authors.lastname: Bech-Hanssen
authors.affiliation: a Department of Cardiology , Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;|c Sahlgrenska University Hospital, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;
authors.forename: Christian Lars
authors.initials: CL
authors.lastname: Polte
authors.affiliation: e Department of Diagnostic Radiation Physics , Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;|f Department of Clinical Sciences , Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;
authors.forename: Kerstin M
authors.initials: KM
authors.lastname: Lagerstrand
authors.affiliation: f Department of Clinical Sciences , Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;|g Department of Radiology , Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden.
authors.forename: Åse A
authors.initials: ÅA
authors.lastname: Johnsson
authors.affiliation: d Heart Centre, King Faisal Specialist Hospital & Research Centre , Riyadh , Kingdom of Saudi Arabia ;
authors.forename: Bahaa M
authors.initials: BM
authors.lastname: Fadel
authors.affiliation: b Department of Clinical Physiology , Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;|c Sahlgrenska University Hospital, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;
authors.forename: Sinsia A
authors.initials: SA
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D002908:Chronic Disease; D061827:Dimensional Measurement Accuracy; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000209:etiology; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D009929:Organ Size; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology
keywords: Aortic regurgitation; cardiovascular magnetic resonance; echocardiography; mitral regurgitation