title: Diagnostic and Prognostic Value of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: a systematic review and meta-analysis.
abstract: Several techniques have been developed to detect circulating tumor cells (CTC) in patients with head and neck squamous cell carcinoma (HNSCC), but their diagnostic and prognostic value are not yet fully established. A computerized retrieval of literatures was conducted without time restrictions using the electronic database in December 2014. Diagnostic accuracy variables were pooled and analyzed by the Meta-DiSc software. Engauge Digitizer and Stata software were used for pooled survival analysis. Twenty-two retrieved studies were eligible for systematic review, of which 9 conformed for the diagnostic test meta-analysis and 5 for the prognostic analysis. Subgroup analysis showed 24.6% pooled sensitivity and 100% pooled specificity of detections by using positive selection strategy, which moreover presented low heterogeneity. The presence of CTC was significantly associated with shorter disease free survival (DFS, HR 4.62, 95% CI 2.51-8.52). In conclusion, current evidence identifies the CTC detection assay as an extremely specific, but low sensitive test in HNSCC. Also, the presence of CTC indicates a worse DFS.
authors.affiliation: Department of Otolaryngology - Head and Neck surgery, Zhongnan Hospital of Wuhan University, China.|SBS Department, CRAN, UMR 7039 CNRS, University of Lorraine, France.|Laboratory of Immunology, Nancytomique platform, CHU of Nancy, France.
authors.forename: Xiang-Lei
authors.initials: XL
authors.lastname: Wu
authors.affiliation: SBS Department, CRAN, UMR 7039 CNRS, University of Lorraine, France.|Laboratory of Immunology, Nancytomique platform, CHU of Nancy, France.
authors.forename: Qian
authors.initials: Q
authors.lastname: Tu
authors.affiliation: SBS Department, CRAN, UMR 7039 CNRS, University of Lorraine, France.|Laboratory of Immunology, Nancytomique platform, CHU of Nancy, France.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Faure
authors.affiliation: Department of Otolaryngology and Cervico-facial Surgery, CHU of Nancy, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Gallet
authors.affiliation: Laboratory of Immunology, Nancytomique platform, CHU of Nancy, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Kohler
authors.affiliation: SBS Department, CRAN, UMR 7039 CNRS, University of Lorraine, France.|Laboratory of Immunology, Nancytomique platform, CHU of Nancy, France.
authors.forename: Marcelo De Carvalho
authors.initials: Mde C
authors.lastname: Bittencourt
mesh_terms: D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000401:mortality*; D005434:Flow Cytometry / Q000379:methods; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000401:mortality*; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D014408:Biomarkers, Tumor
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