title: The neurobiology of MMN and implications for schizophrenia.
abstract: Although the scientific community appears to know a lot about MMN, about its neural generators and the computational processes that underlie its generation, do we have sufficient knowledge to understand what causes the reduction of MMN amplitude in schizophrenia? Here we attempt to integrate the evidence presented in this series of papers for the special issue on MMN in schizophrenia together with evidence from other new relevant research and ask--what have we learnt? While MMN research was the purview for decades of psychophysiologists interested in event-related potentials derived from scalp recorded EEG, it is now part of mainstream neuroscience research attracting the interest of basic auditory neuroscientists, neurobiologists and computational modellers. The confluence of these developments together with increasing clinical research has certainly advanced our understanding of the causes of reduced MMN in schizophrenia as this integrative review attempts to demonstrate--but much remains to be learnt. Future advances will rely on the application of multiple methodologies and approaches in order to arrive at better understanding of the neurobiology of MMN and implications for schizophrenia.
authors.affiliation: School of Psychology, University of Newcastle, Australia; Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle, Australia. Electronic address: pat.michie@newcastle.edu.au.
authors.forename: Patricia T
authors.initials: PT
authors.lastname: Michie
authors.affiliation: Auditory Neurophysiology Unit, Institute of Neuroscience of Castilla y León, University of Salamanca, 37007 Salamanca, Spain; Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
authors.forename: Manuel S
authors.initials: MS
authors.lastname: Malmierca
authors.affiliation: School of Psychology, University of Newcastle, Australia; Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle, Australia.
authors.forename: Lauren
authors.initials: L
authors.lastname: Harms
authors.affiliation: School of Psychology, University of Newcastle, Australia; Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle, Australia.
authors.forename: Juanita
authors.initials: J
authors.lastname: Todd
mesh_terms: D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005544:Forecasting; D006801:Humans; D009446:Neurobiology / Q000639:trends*; D012559:Schizophrenia / Q000503:physiopathology*
keywords: Mismatch negativity (MMN); NMDA receptors; Schizophrenia; Stimulus specific adaptation (SSA)