title: Probability density function of the electric field in diffuse correlation spectroscopy of human bone in vivo.
abstract: Diffuse correlation spectroscopy (DCS) is the technique of choice for non-invasive assessments of human bone blood flow. However, DCS classical algorithms are based on the fundamental assumption that the electric field of the light reaching the DCS photodetector is a zero-mean complex Gaussian variable. The non-validity of this hypothesis might produce inaccurate blood flow estimations. It is shown that for the human tibia, the "Gaussian hypothesis" holds for interoptode distances ≥20  mm. This lower boundary seems to depend on the type of investigated tissue.
authors.forename: Tiziano
authors.initials: T
authors.lastname: Binzoni
authors.forename: Bruno
authors.initials: B
authors.lastname: Sanguinetti
authors.forename: Dimitri
authors.initials: D
authors.lastname: Van de Ville
authors.forename: Hugo
authors.initials: H
authors.lastname: Zbinden
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Martelli
mesh_terms: D001842:Bone and Bones / Q000502:physiology*; D004560:Electricity; D005542:Forearm / Q000502:physiology; D006801:Humans; D008297:Male; D011336:Probability; D013057:Spectrum Analysis / Q000379:methods*; D013977:Tibia / Q000502:physiology