title: [Pathogenesis and clinical condition of hyperphosphatemic diseases].
abstract: Phosphorus is essential mineral to life, which has the multiple roles like postural maintenance or production of energy in the cells. Phosphate overload is harmful and compensatory mechanisms exist. Phosphate is abolished through kidneys and target organ of the compensatory mechanism is also kidneys. It is necessary to evaluate renal function and source of phosphate for estimating the cause of hyperphosphatemia. Acute hyperphosphatemia may cause severe acute kidney injury and avoidance of massive phosphate overload is needed. Chronic hyperphosphatemia have an impact on prognosis because the risk of cardiovascular event increases. Adequate restriction of phosphate intake and use of phosphate absorbent is needed for improvement of prognosis of patients with chronic kidney disease.
authors.affiliation: Division of Nephrology and Metabolism, Tokai University School of Medicine, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Hamano
authors.affiliation: Division of Nephrology and Metabolism, Tokai University School of Medicine, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukagawa
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D002318:Cardiovascular Diseases / Q000209:etiology; D002908:Chronic Disease; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D054559:Hyperphosphatemia / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D009154:Mutation; D017350:N-Acetylgalactosaminyltransferases / Q000235:genetics; D010281:Parathyroid Hormone / Q000502:physiology; D010710:Phosphates / Q000378:metabolism* / Q000502:physiology*; D051436:Renal Insufficiency, Chronic / Q000628:therapy; D000097763:Polypeptide N-acetylgalactosaminyltransferase
chemical_list: D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors; D017350:N-Acetylgalactosaminyltransferases; D010281:Parathyroid Hormone; D010710:Phosphates; D000097763:Polypeptide N-acetylgalactosaminyltransferase