title: Expression of phosphorylated Akt and hTERT is associated with prognosis of epithelial ovarian carcinoma.
abstract: Activation of human telomere reverse transcriptase (hTERT) is associated with the tumorigenic role of Akt. We aimed to evaluate the significance of Akt phosphorylation and hTERT expression on the prognosis of epithelial ovarian cancer (EOC). Between 2005 and 2012, 92 EOC patients treated at the Seoul National University Hospital were included in this study. Paraffin-embedded sections from the tumors of EOC patients were stained with anti-hTERT and anti-phosphorylated Akt (pAkt) antibodies. Correlations of pAkt and hTERT expression with the clinicopathological factors were analyzed using SPSS software, version 17.0 (IBM, Chicago, IL, USA). In 92 EOC tissues, pAkt and hTERT were not associated with any clinicopathological factors. However, the disease-free survival rate of patients exhibiting coexpression of pAkt and hTERT was poor compared with that of the other patients (P = 0.013). Coexpression of pAkt and hTERT is a poor prognostic marker for EOC.
authors.affiliation: Department of Obstetrics and Gyneocology, Cheil General Hospital, College of Medicine, Dankook University Seoul, Korea.
authors.forename: Yoo-Kyung
authors.initials: YK
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Hospital, College of Medicine, Seoul National University Seoul, Korea.
authors.forename: Hyun Hoon
authors.initials: HH
authors.lastname: Chung
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Hospital, College of Medicine, Seoul National University Seoul, Korea.
authors.forename: Jae Weon
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Hospital, College of Medicine, Seoul National University Seoul, Korea.
authors.forename: Yong-Sang
authors.initials: YS
authors.lastname: Song
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Hospital, College of Medicine, Seoul National University Seoul, Korea.
authors.forename: Noh-Hyun
authors.initials: NH
authors.lastname: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D000077216:Carcinoma, Ovarian Epithelial; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D010766:Phosphorylation; D011379:Prognosis; D016016:Proportional Hazards Models; D051057:Proto-Oncogene Proteins c-akt / Q000096:biosynthesis*; D019098:Telomerase / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D051057:Proto-Oncogene Proteins c-akt; C509186:TERT protein, human; D019098:Telomerase
keywords: AKT; Ovarian neoplasm; hTERT; prognosis
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