title: An Anthocyanin-Rich Extract of Acai (Euterpe precatoria Mart.) Increases Stress Resistance and Retards Aging-Related Markers in Caenorhabditis elegans.
abstract: Acai fruits (Euterpe precatoria) are rich in antioxidant anthocyanins. Acai consumption is believed to have many health benefits; however, relevant detailed scientific investigations are limited. The current study aimed to investigate an anthocyanin-rich extract from E. precatoria fruits (AE) with regard to its antioxidant and antiaging properties using the model organism Caenorhabditis elegans. AE can protect the worms against oxidative stress and can ameliorate accumulation of reactive oxygen species in vivo. The expression of stress-response genes, such as sod-3::GFP, was upregulated while hsp-16::GFP was down-regulated after AE treatment. Studies with DAF-16/FOXO mutants indicated that some of the antioxidant effects are mediated by this transcription factor. AE can modulate the development of age-related markers, such as pharyngeal pumping. Despite the apparent antioxidant activity, no lifespan-prolonging effect was observed.
authors.affiliation: Institute of Pharmacy and Molecular Biotechnology, Heidelberg University , , INF 364, D-69120 Heidelberg, Germany.
authors.forename: Herbenya
authors.initials: H
authors.lastname: Peixoto
authors.affiliation: Institute of Pharmacy and Molecular Biotechnology, Heidelberg University , , INF 364, D-69120 Heidelberg, Germany.
authors.forename: Mariana
authors.initials: M
authors.lastname: Roxo
authors.affiliation: Institute of Pharmacy and Molecular Biotechnology, Heidelberg University , , INF 364, D-69120 Heidelberg, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Krstin
authors.affiliation: Department of Food Chemistry and Toxicology, Molecular Nutrition, University of Kaiserslautern , Erwin-Schroedinger-Strasse 52, D-67663 Kaiserslautern, Germany.
authors.forename: Teresa
authors.initials: T
authors.lastname: Röhrig
authors.affiliation: Department of Food Chemistry and Toxicology, Molecular Nutrition, University of Kaiserslautern , Erwin-Schroedinger-Strasse 52, D-67663 Kaiserslautern, Germany.
authors.forename: Elke
authors.initials: E
authors.lastname: Richling
authors.affiliation: Institute of Pharmacy and Molecular Biotechnology, Heidelberg University , , INF 364, D-69120 Heidelberg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Wink
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D015415:Biomarkers / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D065748:Euterpe / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D015415:Biomarkers; D029742:Caenorhabditis elegans Proteins; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C525107:Sod-3 protein, C elegans; D013482:Superoxide Dismutase
keywords: Caenorhabditis elegans; acai; aging; anthocyanins; antioxidants; oxidative stress