title: [Regulatory mechanism of circulating inorganic phosphate].
abstract: Circulating level of phosphate is altered by age and diet, and is also controlled by several hormones such as parathyroid hormone(PTH), 1,25-dihydroxyvitamin D[1,25(OH)2D]and fibroblast growth factor 23(FGF23). The main function of PTH and 1,25(OH)2D is maintaining calcium homeostasis, while FGF23 plays a central role in phosphate metabolism. PTH suppresses phosphate reabsorption in the proximal tubules to increase the renal phosphate wasting, while 1,25(OH)2D facilitates the intestinal phosphate absorption. FGF23 increases the renal phosphate wasting and reduces the production of 1,25(OH)2D. Of note, these hormones mutually regulate one another. The production of FGF23 is also regulated by various local factors. The mechanism for sensing the phosphate availability still remains unknown, and further investigation is required.
authors.affiliation: Department of Bone and Mineral Research,Osaka Medical Center and Research Institute for Maternal and Child Health, Japan.
authors.forename: Toshimi
authors.initials: T
authors.lastname: Michigami
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D002117:Calcitriol / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D004032:Diet; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D007408:Intestinal Absorption / Q000235:genetics; D007684:Kidney Tubules / Q000378:metabolism; D010281:Parathyroid Hormone / Q000502:physiology*; D010710:Phosphates / Q000378:metabolism*
chemical_list: C000717427:FGF23 protein, human; D010281:Parathyroid Hormone; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002117:Calcitriol; D002118:Calcium