title: Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia.
abstract: Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy, and its association with obstetric outcomes, such as preeclampsia. This nested case-control study in a longitudinal cohort included normal pregnant (n = 54) and preeclamptic (n = 18) women, both followed throughout pregnancy. Additionally, some of the normal pregnant women were followed up three months postpartum (n = 18). Healthy non-pregnant women were also studied during their menstrual cycle (n = 20). The results of this study show that in healthy non-pregnant women, adipsin levels did not change significantly during the menstrual cycle. In normal pregnant women, adipsin levels were lower (p < 0.01) when compared with non-pregnant healthy women, but these serum levels increased again during postpartum (p < 0.001). Adipsin levels were significantly elevated in preeclamptic women in late pregnancy (P < 0.01). A significant correlation was not found between leptin and adipsin during the three periods of gestation studied in healthy pregnant and preeclamptic women. Our results suggest that adipsin may be involved in pregnancy-associated metabolic changes. Moreover, the increase of adipsin levels towards late gestation in preeclamptic women could be related to the pathophysiology of this disease.
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Natalia E
authors.initials: NE
authors.lastname: Poveda
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: María F
authors.initials: MF
authors.lastname: Garcés
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Ruiz-Linares
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Diana
authors.initials: D
authors.lastname: Varón
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Sergio
authors.initials: S
authors.lastname: Valderrama
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sanchez
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Adriana
authors.initials: A
authors.lastname: Castiblanco-Cortes
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Yessica
authors.initials: Y
authors.lastname: Agudelo-Zapata
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Héctor Fabio
authors.initials: HF
authors.lastname: Sandoval-Alzate
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Luis G
authors.initials: LG
authors.lastname: Leal
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Edith
authors.initials: E
authors.lastname: Ángel-Müller
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Ariel I
authors.initials: AI
authors.lastname: Ruíz-Parra
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Angélica M
authors.initials: AM
authors.lastname: González-Clavijo
authors.affiliation: Department of Physiology (CIMUS), School of Medicine-Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Diéguez
authors.affiliation: Department of Physiology (CIMUS), School of Medicine-Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Nogueiras
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Caminos
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