title: Lecithin, gelatin and hydrolyzed collagen orally disintegrating films: functional properties.
abstract: Orally disintegrating films (ODFs) can transport natural active compounds such as ethanol extract of propolis (EEP). This paper aimed to investigate the effect of lecithin on different gelatin and hydrolyzed collagen (HC) polymeric matrices with addition of EEP. ODFs were prepared by casting technique and were characterized (color parameters, water content, mechanical properties, microstructure, disintegration time (DT), infrared spectroscopy (FTIR), contact angle (CA), swelling degree and total phenolic content). The mechanical properties were influenced by HC. The microstructure demonstrated increased porosity and roughness in films with EEP, and the addition of lecithin resulted in an increase in the number of pores. Lecithin-gelatin and lecithin-EEP-gelatin interactions were observed by FTIR. The addition of HC and EEP reduced the DT and CA, and HC and lecithin reduced the swelling capacity. However, the swelling capacity was not affected by presence of EEP. The addition of lecithin to gelatin and HC ODFs may improve the incorporation and the oral transport of active compounds such as EEP.
authors.affiliation: Faculty of Animal Science and Food Engineering, University of São Paulo - FZEA/USP, Av. Duque de Caxias Norte 225, 13635-900, Pirassununga, SP, Brazil.
authors.forename: J G
authors.initials: JG
authors.lastname: Borges
authors.affiliation: Faculty of Animal Science and Food Engineering, University of São Paulo - FZEA/USP, Av. Duque de Caxias Norte 225, 13635-900, Pirassununga, SP, Brazil.
authors.forename: A G
authors.initials: AG
authors.lastname: Silva
authors.affiliation: Faculty of Animal Science and Food Engineering, University of São Paulo - FZEA/USP, Av. Duque de Caxias Norte 225, 13635-900, Pirassununga, SP, Brazil.
authors.forename: C M
authors.initials: CM
authors.lastname: Cervi-Bitencourt
authors.affiliation: Faculty of Animal Science and Food Engineering, University of São Paulo - FZEA/USP, Av. Duque de Caxias Norte 225, 13635-900, Pirassununga, SP, Brazil.
authors.forename: F M
authors.initials: FM
authors.lastname: Vanin
authors.affiliation: Faculty of Animal Science and Food Engineering, University of São Paulo - FZEA/USP, Av. Duque de Caxias Norte 225, 13635-900, Pirassununga, SP, Brazil. Electronic address: rosecarvalho@usp.br.
authors.forename: R A
authors.initials: RA
authors.lastname: Carvalho
mesh_terms: D003094:Collagen / Q000737:chemistry*; D003116:Color; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D000431:Ethanol / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D054709:Lecithins / Q000737:chemistry*; D055595:Mechanical Phenomena; D019800:Phenol / Q000032:analysis; D011429:Propolis / Q000737:chemistry; D012463:Saliva / Q000378:metabolism*; D014867:Water / Q000032:analysis
chemical_list: D004337:Drug Carriers; D054709:Lecithins; D014867:Water; D019800:Phenol; D000431:Ethanol; D005780:Gelatin; D003094:Collagen; D011429:Propolis
keywords: Bioactive compound; Natural polymers; Structure