title: Sigma-1 receptors: a new pathway for the modulation of store-operated calcium entry.
abstract: SOCE (store-operated Ca(2+) entry) is a ubiquitous mechanism for Ca(2+) influx in animal cells. In a recent issue of the Biochemical Journal, Brailoiu and colleagues reported that cocaine attenuates SOCE in rat brain microvascular endothelial cells, via a mechanism that requires the expression and activation of the sigma-1 receptor, a chaperone located in the endoplasmic reticulum-mitochondrion interface that modulates intracellular Ca(2+) homoeostasis and cell survival. This study envisages a pathway through which cocaine modulates endothelial function via regulation of SOCE. The regulation of SOCE by sigma-1 receptors provides a novel and important pathway in Ca(2+) signalling.
authors.affiliation: Department of Physiology (Cell Physiology Research Group), University of Extremadura, Cáceres 10003, Spain jarosado@unex.es.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Rosado
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D042783:Endothelial Cells / Q000378:metabolism; D051381:Rats; D017480:Receptors, sigma / Q000235:genetics / Q000378:metabolism*; D000097605:Sigma-1 Receptor
chemical_list: D002118:Calcium; D015220:Calcium Channels; D003042:Cocaine; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor
keywords: calcium homoeostasis; calcium signalling; cocaine; endothelial function; sigma-1 receptor; store-operated calcium entry