title: Dose-dependent Medicinal Effects of Thymus haussknechtii Velen Grown Wild in Turkey.
abstract: In this study, it was aimed to determine dose-dependent interactions between phenolic contents and antioxidant, antibacterial and antifungal effect mechanisms of the infusions of Thymus haussknechtii Velen, naturally grown in the Eastern Anatolia region of Turkey. Therefore, the infusions of Thymus haussknechtii were tested and the interactions between phenolic contents and antioxidant, antibacterial and antifungal effect mechanisms were determined by way of different antioxidant, antibacterial and antioxidant test systems. The concentrations of Thymus haussknechtii showed strong hydrogen peroxide scavenging activity and free radical scavenging activity [1,1-diphenyl-2-picryl-hydrazil (DPPH) % inhibition]. Also, it was seen that Thymus haussknechtii infusions possessed strong antibacterial and antifungal activity against different gram negative and positive bacteria and fungi. In this study, positive correlations between antioxidant, antibacterial, antifungal potency and the total phenolic content of Thymus haussknechtii were found. When the concentration differences were examined, it was seen that concentrations of 4% had the most strong antioxidant, antibacterial and antifungal activity. As a result, Thymus haussknechtii can be reliable antioxidant, antibacterial antifungal substance at concentrations of 4% when it is used as a supplement to therapeutic regimens and for medicinal purposes.
authors.affiliation: Department of Nutrition and Dietetic, School of Health, University of Erzincan, Erzincan, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kılıçgün
authors.affiliation: University of Erzincan, Faculty of Arts and Sciences, Department of Biology.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Korkmaz
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D010936:Plant Extracts / Q000494:pharmacology*; D046930:Thymus Plant / Q000737:chemistry; D014421:Turkey
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000975:Antioxidants; D010936:Plant Extracts