title: Retrospective analysis of reproductive outcomes in women with primary ovarian insufficiency showing intermittent follicular development.
abstract: The aim of this retrospective study was to explore the reproductive outcomes of IVF treatment in women with primary ovarian insufficiency (POI) showing intermittent follicular development. A total of 44 POI women with normal karyotype and absent autoimmunity, attending the centre for fertility treatment at Nanfang Hospital, Guangzhou from March 2009 to March 2011, were identified as suitable for inclusion in this study. Out of 44 women, 20 (20/44; 45.5%) had growing follicles and 13 underwent 27 oocyte retrievals. The empty follicle rate per oocyte retrieval was 70.4% (19/27); eight oocytes were recovered: one (12.5%) germinal vesicle (GV), two (25.0%) metaphase I (MI), one (12.5%) metaphase II (MII), and four (50.0%) atretic. One MI oocyte matured in vitro and two women had embryo transfer. Only the woman with the MI oocyte matured in vitro conceived, giving birth to a healthy baby at term. These results suggest that intermittent follicular development is common in women with POI but most of the developed follicles are empty or contain atretic oocytes. The pregnancy rate remains very low for IVF treatment.
authors.affiliation: Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: chensl_92@163.com.
authors.forename: Shi-Ling
authors.initials: SL
authors.lastname: Chen
authors.affiliation: Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Ye
authors.affiliation: Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Liu
authors.affiliation: Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Yu-Xia
authors.initials: YX
authors.lastname: He
authors.affiliation: Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Tian
authors.affiliation: Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Xu
authors.affiliation: Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Tao
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D054315:Oocyte Retrieval; D006080:Ovarian Follicle / Q000473:pathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D016649:Primary Ovarian Insufficiency / Q000150:complications / Q000503:physiopathology*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Empty follicle; In vitro fertilization; Primary ovarian insufficiency