title: Prognosis of eyelid sebaceous gland carcinoma based on the tumor (T) category of the American Joint Committee on Cancer (AJCC) classification.
abstract: The purpose of this study was to evaluate the clinical features and prognosis of eyelid sebaceous gland carcinoma (SGC) based on the T category of the American Joint Committee on Cancer (AJCC) classification (7th edition). This is a retrospective interventional case series study. Based on the T category of the AJCC classification, 191 patients with eyelid sebaceous gland carcinoma were classified as T1 (n = 1, 1 %), T2 (n = 111, 58 %), T3 (n = 76, 40 %), and T4 (n = 3, 2 %). Based on multivariate analysis, the factors predictive of regional lymph node metastasis included duration of symptoms >6 months (p = 0.04) and orbital tumor extension (p < 0.001). The factors predictive of systemic metastasis included orbital tumor extension (p < 0.001) and perivascular invasion (p = 0.007). The factor predictive of death due to systemic metastasis included orbital tumor extension (p < 0.001). Kaplan-Meier estimates of regional lymph node metastasis at 5 and 10 years, respectively, were 0 and 0 % for T1, 11 and 11 % for T2, 44 and 59 % for T3, and 100 and 100 % for T4 (p < 0.001). Kaplan-Meier estimates of systemic metastasis at 5 and 10 years, respectively, were 0 and 0 % for T1, 6 and 6 % for T2, 35 and 35 % for T3, and 100 and 100 % for T4 (p < 0.001). Kaplan-Meier estimates of death due to metastasis at 5 and 10 years, respectively, were 0 and 0 % for T1, 3 and 3 % for T2, 30 and 50 % for T3, and 100 and 100 % for T4 (p < 0.001). Primary tumor (T) category of the AJCC classification predicts the prognosis of patients with eyelid SGC. The risk of systemic metastasis and death increases with increasing tumor category.
authors.affiliation: The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, 500034, India. kalikiswathi@yahoo.com.
authors.forename: Swathi
authors.initials: S
authors.lastname: Kaliki
authors.affiliation: The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, 500034, India.
authors.forename: Adit
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Center for Clinical Epidemiology and Bio-Statistics (MHA), L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Mohammed Hasnat
authors.initials: MH
authors.lastname: Ali
authors.affiliation: The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, 500034, India.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Ayyar
authors.affiliation: The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, 500034, India.
authors.forename: Milind N
authors.initials: MN
authors.lastname: Naik
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000145:classification / Q000175:diagnosis* / Q000401:mortality; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005142:Eyelid Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012626:Sebaceous Gland Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000401:mortality; D015996:Survival Rate; D055815:Young Adult
keywords: AJCC; Death; Eye; Metastasis; Sebaceous gland carcinoma; Tumor
references.citation: Eye (Lond). 2015 Jul;29(7):958-63
references.pmid: 25998946
references.citation: Ophthalmology. 2013 Oct;120(10):2066-71
references.pmid: 23664467
references.citation: Arch Ophthalmol. 2012 May;130(5):599-606
references.pmid: 22652846
references.citation: J Clin Oncol. 2013 Aug 1;31(22):2825-31
references.pmid: 23816968
references.citation: Arch Pathol Lab Med. 2009 Aug;133(8):1256-61
references.pmid: 19653721
references.citation: Ophthal Plast Reconstr Surg. 2012 Sep-Oct;28(5):313-23
references.pmid: 22965011
references.citation: Br J Ophthalmol. 2014 Apr;98(4):498-501
references.pmid: 24429279
references.citation: Br J Ophthalmol. 2013 Nov;97(11):1459-63
references.pmid: 24037608
references.citation: Cornea. 2013 Mar;32(3):248-56
references.pmid: 22580436
references.citation: Arch Ophthalmol. 2012 Feb;130(2):159-64
references.pmid: 22332208
references.citation: Chin Med J (Engl). 1979 Oct;92(10):671-6
references.pmid: 116808
references.citation: Br J Ophthalmol. 2014 Dec;98(12):1681-5
references.pmid: 25053759
references.citation: Eye (Lond). 2004 Jan;18(1):49-53
references.pmid: 14707966
references.citation: Hum Pathol. 1982 Feb;13(2):113-22
references.pmid: 7076199
references.citation: Am J Hematol. 2011 Mar;86(3):262-6
references.pmid: 21328439
references.citation: Ophthal Plast Reconstr Surg. 1991;7(1):61-6
references.pmid: 2018750
references.citation: Ophthalmology. 2009 Jun;116(6):1210-5
references.pmid: 19395039
references.citation: Arch Ophthalmol. 2012 May;130(5):664-6
references.pmid: 22652862
references.citation: Ophthalmology. 2012 May;119(5):1078-82
references.pmid: 22330966
references.citation: Ophthalmology. 2004 Dec;111(12):2151-7
references.pmid: 15582067
references.citation: Orbit. 2011 Oct;30(5):202-7
references.pmid: 21957948