title: Comparative Evaluation of Liposomal Albendazole and Tablet-Albendazole Against Hepatic Cystic Echinococcosis: A Non-Randomized Clinical Trial.
abstract: In this study, we aimed to compare the clinical efficacy of liposomal albendazole (L-ABZ) and tablet-albendazole (T-ABZ) for the treatment of human hepatic cystic echinococcosis (CE). Sixty patients with single cyst (CE1) or daughter cyst (CE2) were included in this study and were nonrandomly divided into the L-ABZ group (n = 30, 10  mg/kg per day, p.o., b.i.d.) and T-ABZ group (n = 30, 12-20 mg/kg per day, p.o., b.i.d.), respectively. The treatment duration lasted for 6 months, during which dynamic follow-up was carried out to evaluate the clinical efficacy through calculating the total effective rates (TERs). Measurement data and numerous data were analyzed by the chi-square test. Two-sided tests were performed for all the statistical tests. In our study, 2 patients were lost in the follow-up in the L-ABZ group. One patient was lost in the follow-up in the T-ABZ group, and 1 patient was withdrawal from the study due to receiving surgery. Significant difference was identified in the 3-month TERs of L-ABZ group and T-ABZ group (33.3% vs 76.7%, P < 0.05). Also, remarkable difference was noted in the 6-month TERs in the L-ABZ group and T-ABZ group (66.7% vs 93.3%, P = 0.01). No statistical difference was noticed in the incidence rate of adverse reactions in both groups (P > 0.05). Based on our study, both T-ABZ and L-ABZ are effective for treating human CE. The TER in the L-ABZ group is superior to that of T-ABZ.
authors.affiliation: From the State Key Lab Incubation Base of Xinjiang Major Diseases Research (2010DS890294) and Xinjiang Key Laboratory of Echinococcosis (HL, TS, YS, TA, AA, HW); Hepatobiliary & Hydatid Department, Digestive and Vascular Surgery Centre (HT, TA, AA, HW); and Department of Ultrasonography, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China (TS, YS).
authors.forename: Haitao
authors.initials: H
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Song
authors.forename: Yingmei
authors.initials: Y
authors.lastname: Shao
authors.forename: Tuergan
authors.initials: T
authors.lastname: Aili
authors.forename: Ayifuhan
authors.initials: A
authors.lastname: Ahan
authors.forename: Hao
authors.initials: H
authors.lastname: Wen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015766:Albendazole / Q000008:administration & dosage* / Q000009:adverse effects; D000923:Anticestodal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004444:Echinococcosis, Hepatic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D013607:Tablets; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000923:Anticestodal Agents; D008081:Liposomes; D013607:Tablets; D015766:Albendazole
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