title: Normal Amplitude of Electroretinography and Visual Evoked Potential Responses in AβPP/PS1 Mice.
abstract: Alzheimer's disease has been shown to affect vision in human patients and animal models. This may pose the risk of bias in behavior studies and therefore requires comprehensive investigation. We recorded electroretinography (ERG) under isoflurane anesthesia and visual evoked potentials (VEP) in awake amyloid expressing AβPPswe/PS1dE9 (AβPP/PS1) and wild-type littermate mice at a symptomatic age. The VEPs in response to patterned stimuli were normal in AβPP/PS1 mice. They also showed normal ERG amplitude but slightly shortened ERG latency in dark-adapted conditions. Our results indicate subtle changes in visual processing in aged male AβPP/PS1 mice specifically at a retinal level.
authors.forename: Henri
authors.initials: H
authors.lastname: Leinonen
authors.forename: Arto
authors.initials: A
authors.lastname: Lipponen
authors.forename: Kestutis
authors.initials: K
authors.lastname: Gurevicius
authors.forename: Heikki
authors.initials: H
authors.lastname: Tanila
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D015350:Contrast Sensitivity / Q000235:genetics; D004195:Disease Models, Animal; D004569:Electroencephalography; D004596:Electroretinography; D005074:Evoked Potentials, Visual / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D010775:Photic Stimulation; D053764:Presenilin-1 / Q000235:genetics; D011930:Reaction Time / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor; C508853:PSEN1 protein, human; D053764:Presenilin-1
keywords: Alzheimer disease; amyloid-beta; animal models; electroretinography; vision; visual evoked potentials