title: Visual Outcomes and Accommodative Response of the Lumina Accommodative Intraocular Lens.
abstract: OBJECTIVE
  To compare visual acuity, accommodation, and contrast sensitivity of the AkkoLens Lumina accommodative intraocular lens (AkkoLens Clinical b.v., Breda, The Netherlands) with a standard monofocal intraocular lens (IOL).
  
  
  METHODS
  Randomized clinical trial.
  
  
  METHODS
  The study enrolled 86 eyes with cataract that all required cataract surgery and IOL implantation. The study group included 61 eyes that were implanted with the Lumina. The control group included 25 eyes that were implanted with an Acrysof SA60AT (Alcon, Fort Worth, TX, USA) monofocal IOL. The distance and near visual acuities, contrast sensitivity, and accommodation were measured over a 1-year follow-up period. Accommodation was measured subjectively, using defocus curves, and objectively, with an open-field autorefractor.
  
  
  RESULTS
  Uncorrected (UDVA) and corrected (CDVA) distance visual acuities did not differ significantly between the groups (P ≥ .21) over the 12 months. However, the uncorrected near visual acuity (UNVA) was 0.07 ± 0.08 logRAD for the Lumina group and 0.37 ± 0.19 logRAD for the control group (P < .01) and the corrected distance near visual acuity (CDNVA) was 0.11 ± 0.12 LogRAD for the Lumina group and 0.41 ± 0.15 LogRAD for the control group (P < .01). Defocus curves showed a statistically significant difference between groups for defocus ranging from -4.50 to -0.50 diopters (D) (P < .01) with significantly higher visual acuities for the Lumina group. Subjective accommodation, as determined from defocus curves, was 3.05 ± 1.06, 3.87 ± 1.27, and 5.59 ± 1.02 D for the Lumina group and 1.46 ± 0.54, 2.00 ± 0.52, and 3.67 ± 0.75 D for the control group at visual acuities of 0.10, 0.20, and 0.4 logMAR for both groups, respectively. The objective accommodation, measured by an open-field autorefractor, was 0.63 ± 0.41, 0.69 ± 0.45, 0.91 ± 0.51, and 1.27 ± 0.76 D for the Lumina group and 0.10 ± 0.15, 0.12 ± 0.15, -0.06 ± 0.09 and 0.07 ± 0.10 D for the control group at accommodation stimuli of 2.0, 2.5, 3.0, and 4.0 D, respectively. Contrast sensitivity was the same for both groups (P ≥ .26).
  
  
  CONCLUSIONS
  The Lumina accommodative IOL effectively restores the visual function, accommodation, and contrast sensitivity after cataract surgery with no influence on the postoperative contrast sensitivity.
authors.affiliation: Vissum Alicante, Alicante, Spain; Division of Ophthalmology, Universidad Miguel Hernández, Alicante, Spain. Electronic address: jlalio@vissum.com.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Alio
authors.affiliation: AkkoLens Clinical b.v., Breda, Netherlands.
authors.forename: Aleksey
authors.initials: A
authors.lastname: Simonov
authors.affiliation: Vissum Alicante, Alicante, Spain.
authors.forename: Ana Belén
authors.initials: AB
authors.lastname: Plaza-Puche
authors.affiliation: Resbiomed-Vissum Sofia Eye Clinic, Sofia, Bulgaria.
authors.forename: Alexander
authors.initials: A
authors.lastname: Angelov
authors.affiliation: Resbiomed-Vissum Sofia Eye Clinic, Sofia, Bulgaria.
authors.forename: Yavor
authors.initials: Y
authors.lastname: Angelov
authors.affiliation: AkkoLens Clinical b.v., Breda, Netherlands.
authors.forename: Willem
authors.initials: W
authors.lastname: van Lawick
authors.affiliation: AkkoLens Clinical b.v., Breda, Netherlands.
authors.forename: Michiel
authors.initials: M
authors.lastname: Rombach
mesh_terms: D000065:Accommodation, Ocular / Q000502:physiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015350:Contrast Sensitivity / Q000502:physiology*; D019781:Corneal Topography; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D018918:Phacoemulsification; D011446:Prospective Studies; D011474:Prosthesis Design; D019591:Pseudophakia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology*