title: BleeMACS: rationale and design of the study.
abstract: BACKGROUND
  Bleeding events after an acute coronary syndrome have a negative impact on prognosis. Available risk scores are limited by suboptimal accuracy, prediction of only in-hospital events and absence of patients treated with new antiplatelet agents in the current era of widespread use of percutaneous coronary intervention.
  
  
  METHODS
  The BleeMACS (Bleeding complications in a Multicenter registry of patients discharged after an Acute Coronary Syndrome) project is a multicenter investigator-initiated international retrospective registry that enrolled more than 15 000 patients discharged with a definitive diagnosis of acute coronary syndrome and treated with percutaneous revascularization. The primary end point is the incidence of major bleeding events requiring hospitalization and/or red cell transfusion concentrates within 1 year. An integer risk score for bleeding within the first year after hospital discharge will be developed from a multivariate competing-risks regression.
  
  
  CONCLUSIONS
  The BleeMACS registry collaborative will allow development and validation of a risk score for prediction of major bleeding during follow-up for patients receiving contemporary therapies for acute coronary syndrome.
authors.affiliation: aDipartimento di Scienze Mediche, Divisione di Cardiologia, Città della Salute e della Scienza, Turin, Italy bUniversity Clinical Hospital, Santiago de Compostela, Spain cUniversity Academic Medical Center, Amsterdam, The Netherlands dNorthShore University Hospital, Chicago, Illinois, USA eLibin Cardiovascular Institute of Alberta, Calgary, Canada fSan Carlos Hospital, Madrid gBellvitge Hospital, Barcelona, Spain hAnzhen Hospital, Beijing, China iUniversity Patras Hospital, Athens, Greece jKerckhoff Heart and Thorax Center, Frankfurt, Germany kUniversity Clinical Hospital, Kyoto, Japan lUniversity Clinical Hospital, Warsaw, Poland mInstitute of Heart, Lung and Blood Vessel Disease, Beijing, China nTokai University School of Medicine, Tokyo, Japan oUniversity Bahian Medical School, Salvador, Brazil pDivision of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan qUniversity Clinic of Cardiology, Skopje, Macedonia.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: D'Ascenzo
authors.forename: Emad
authors.initials: E
authors.lastname: Abu-Assi
authors.forename: Sergio
authors.initials: S
authors.lastname: Raposeiras-Roubín
authors.forename: José Paulo
authors.initials: JP
authors.lastname: Simao Henriques
authors.forename: Jorge
authors.initials: J
authors.lastname: Saucedo
authors.forename: José Ramon
authors.initials: JR
authors.lastname: González-Juanatey
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Wilton
authors.forename: Wouter J
authors.initials: WJ
authors.lastname: Kikkert
authors.forename: Iván
authors.initials: I
authors.lastname: Nuñez-Gil
authors.forename: Albert
authors.initials: A
authors.lastname: Ariza-Sole
authors.forename: Xiantao
authors.initials: X
authors.lastname: Song
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Alexopoulos
authors.forename: Christoph
authors.initials: C
authors.lastname: Liebetrau
authors.forename: Tetsuma
authors.initials: T
authors.lastname: Kawaji
authors.forename: Claudio
authors.initials: C
authors.lastname: Moretti
authors.forename: Zenon
authors.initials: Z
authors.lastname: Huczek
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Nie
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Fujii
authors.forename: Luis Claudio
authors.initials: LC
authors.lastname: Correia
authors.forename: Masa-Aki
authors.initials: MA
authors.lastname: Kawashiri
authors.forename: José María
authors.initials: JM
authors.lastname: García-Acuña
authors.forename: Danielle
authors.initials: D
authors.lastname: Southern
authors.forename: Emilio
authors.initials: E
authors.lastname: Alfonso
authors.forename: Belén
authors.initials: B
authors.lastname: Terol
authors.forename: Alberto
authors.initials: A
authors.lastname: Garay
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Zhang
authors.forename: Yalei
authors.initials: Y
authors.lastname: Chen
authors.forename: Ioanna
authors.initials: I
authors.lastname: Xanthopoulou
authors.forename: Neriman
authors.initials: N
authors.lastname: Osman
authors.forename: Helge
authors.initials: H
authors.lastname: Möllmann
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shiomi
authors.forename: Francesca
authors.initials: F
authors.lastname: Giordana
authors.forename: Silvia
authors.initials: S
authors.lastname: Scarano
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Gaita
authors.forename: Michal
authors.initials: M
authors.lastname: Kowara
authors.forename: Krzysztof J
authors.initials: KJ
authors.lastname: Filipiak
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Jing-Yao
authors.initials: JY
authors.lastname: Fan
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ikari
authors.forename: Takuya
authors.initials: T
authors.lastname: Nakahayshi
authors.forename: Kenji
authors.initials: K
authors.lastname: Sakata
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamagishi
authors.forename: Oliver
authors.initials: O
authors.lastname: Kalpak
authors.forename: Sasko
authors.initials: S
authors.lastname: Kedev
mesh_terms: D054058:Acute Coronary Syndrome / Q000601:surgery*; D006470:Hemorrhage / Q000453:epidemiology* / Q000209:etiology; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007391:International Cooperation; D015999:Multivariate Analysis; D010351:Patient Discharge; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D011183:Postoperative Complications / Q000453:epidemiology*; D012042:Registries; D012044:Regression Analysis; D012107:Research Design; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors