title: Preliminary analysis showed country-specific gut resistome based on 1,267 feces samples.
abstract: Gut microbiota (GM) plays an important role in drug metabolism and absorption. Ever-increasing antibiotic use could result in high accumulation of antibiotic resistance genes (ARGs) in GM, which will reduce the recovery rate of many infectious diseases. The foci of this study is to unravel ARG distribution in GM of 1267 subjects from four countries in three continents, by annotation with ARDB (Antibiotic Resistance Genes Database) and ARG-ANNOT database. Analysis results showed that all three continents had similar ARG composition, but Chinese had the highest ARG relative abundance, followed by American and European. This is possibly attributed to delayed policies on antibiotic use in China, and restrict legislation in Europe. Delivery time and application scope are proportional to ARG enrichment in GM. Findings in this study indicate that ARG accumulation could be associated with government policies on antibiotic use, and corresponding delivery time and application scope, which will be a significant reference to control antibiotic abuse.
authors.affiliation: WeHealthGene, Shenzhen 518000, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Beijing Chest Hospital Capital Medical University/Beijing TB & Thoracic Tumor Research Institute, Beijing 100035, China.
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Guo
authors.affiliation: WeHealthGene, Shenzhen 518000, China.
authors.forename: Chuangzhao
authors.initials: C
authors.lastname: Qiu
authors.affiliation: WeHealthGene, Shenzhen 518000, China.
authors.forename: Yinhu
authors.initials: Y
authors.lastname: Li
authors.affiliation: WeHealthGene, Shenzhen 518000, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Feng
authors.affiliation: BGI Shenzhen, Shenzhen 518083, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: WeHealthGene, Shenzhen 518000, China.
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Baoji City Chinese Medicine Hospital, Baoji 721001, China.
authors.forename: Pengyu
authors.initials: P
authors.lastname: Pang
authors.affiliation: WeHealthGene, Shenzhen 518000, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: WeHealthGene, Shenzhen 518000, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Computer Science, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Han
authors.affiliation: WeHealthGene, Shenzhen 518000, China. Electronic address: daiwk@wehealthgene.com.
authors.forename: Wenkui
authors.initials: W
authors.lastname: Dai
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002681:China; D004352:Drug Resistance, Microbial; D005060:Europe; D005243:Feces / Q000382:microbiology*; D000069196:Gastrointestinal Microbiome / Q000187:drug effects; D005798:Genes, Bacterial; D006801:Humans; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents
keywords: ARGs; Antibiotic; Gut microbiota