title: Prognostic Indicators for Ebola Patient Survival.
abstract: To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus-positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus-positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of <24 survived. Ct values may be useful for clinicians making treatment decisions or managing patient or family expectations.
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Crowe
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Maenner
authors.forename: Solomon
authors.initials: S
authors.lastname: Kuah
authors.forename: Bobbie Rae
authors.initials: BR
authors.lastname: Erickson
authors.forename: Megan
authors.initials: M
authors.lastname: Coffee
authors.forename: Barbara
authors.initials: B
authors.lastname: Knust
authors.forename: John
authors.initials: J
authors.lastname: Klena
authors.forename: Joyce
authors.initials: J
authors.lastname: Foday
authors.forename: Darren
authors.initials: D
authors.lastname: Hertz
authors.forename: Veerle
authors.initials: V
authors.lastname: Hermans
authors.forename: Jay
authors.initials: J
authors.lastname: Achar
authors.forename: Grazia M
authors.initials: GM
authors.lastname: Caleo
authors.forename: Michel
authors.initials: M
authors.lastname: Van Herp
authors.forename: César G
authors.initials: CG
authors.lastname: Albariño
authors.forename: Brian
authors.initials: B
authors.lastname: Amman
authors.forename: Alison Jane
authors.initials: AJ
authors.lastname: Basile
authors.forename: Scott
authors.initials: S
authors.lastname: Bearden
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Belser
authors.forename: Eric
authors.initials: E
authors.lastname: Bergeron
authors.forename: Dianna
authors.initials: D
authors.lastname: Blau
authors.forename: Aaron C
authors.initials: AC
authors.lastname: Brault
authors.forename: Shelley
authors.initials: S
authors.lastname: Campbell
authors.forename: Mike
authors.initials: M
authors.lastname: Flint
authors.forename: Aridth
authors.initials: A
authors.lastname: Gibbons
authors.forename: Christin
authors.initials: C
authors.lastname: Goodman
authors.forename: Laura
authors.initials: L
authors.lastname: McMullan
authors.forename: Christopher
authors.initials: C
authors.lastname: Paddock
authors.forename: Brandy
authors.initials: B
authors.lastname: Russell
authors.forename: Johanna S
authors.initials: JS
authors.lastname: Salzer
authors.forename: Angela
authors.initials: A
authors.lastname: Sanchez
authors.forename: Tara
authors.initials: T
authors.lastname: Sealy
authors.forename: David
authors.initials: D
authors.lastname: Wang
authors.forename: Gbessay
authors.initials: G
authors.lastname: Saffa
authors.forename: Alhajie
authors.initials: A
authors.lastname: Turay
authors.forename: Stuart T
authors.initials: ST
authors.lastname: Nichol
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Towner
mesh_terms: D000293:Adolescent; D000328:Adult; D029043:Ebolavirus; D005260:Female; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000401:mortality* / Q000821:virology*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011159:Population Surveillance; D011379:Prognosis; D012807:Sierra Leone / Q000453:epidemiology; D055815:Young Adult
keywords: Ebola; Ebola virus; Ebola virus disease; Sierra Leone; hemorrhagic fever; prognosis; survival; viruses; zoonoses
references.citation: J Infect Dis. 1999 Feb;179 Suppl 1:S87-91
references.pmid: 9988169
references.citation: N Engl J Med. 2014 Nov 27;371(22):2054-7
references.pmid: 25372854
references.citation: N Engl J Med. 2014 Sep 25;371(13):1177-80
references.pmid: 25140858
references.citation: J Infect Dis. 2015 Dec 1;212(11):1752-8
references.pmid: 26002981
references.citation: Bull World Health Organ. 1983;61(6):997-1003
references.pmid: 6370486
references.citation: Lancet. 2011 Mar 5;377(9768):849-62
references.pmid: 21084112
references.citation: J Infect Dis. 2007 Nov 15;196 Suppl 2:S364-71
references.pmid: 17940972
references.citation: N Engl J Med. 2014 Oct 23;371(17):1565-6
references.pmid: 25251518
references.citation: Lancet. 2014 Oct 4;384(9950):1260
references.pmid: 25260235
references.citation: N Engl J Med. 2014 Oct 16;371(16):1481-95
references.pmid: 25244186
references.citation: J Virol. 2004 Apr;78(8):4330-41
references.pmid: 15047846
references.citation: Clin Microbiol Infect. 2011 Jul;17(7):964-76
references.pmid: 21722250
references.citation: Clin Infect Dis. 2015 Aug 15;61(4):491-5
references.pmid: 25995207
references.citation: N Engl J Med. 2014 Oct 9;371(15):1418-25
references.pmid: 24738640
references.citation: J Infect Dis. 2011 Nov;204 Suppl 3:S810-6
references.pmid: 21987756
references.citation: N Engl J Med. 2015 Feb 5;372(6):587-8
references.pmid: 25539447
references.citation: J Infect Dis. 2014 Aug 15;210(4):558-66
references.pmid: 24526742
references.citation: Ann Am Thorac Soc. 2014 Nov;11(9):1341-50
references.pmid: 25369317
references.citation: N Engl J Med. 2014 Nov 27;371(22):2092-100
references.pmid: 25353969
references.citation: Emerg Infect Dis. 2015 Oct;21(10):1800-7
references.pmid: 26402477
references.citation: Am J Respir Crit Care Med. 2014 Oct 1;190(7):733-7
references.pmid: 25166884