title: Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus.
abstract: OBJECTIVE
  To assess glycated albumin (GA) as a potential glycemic index in managing gestational diabetes mellitus (GDM).
  
  
  METHODS
  Eligible pregnant women were divided into the GDM group with abnormal result on a 75-g oral glucose tolerance test (OGTT) and the control (normal) group. GA measurements, Pearson's correlation analysis, multiple logistic regression and receiver operating characteristic curve analysis were obtained at the follow-up examination of participants in the two groups.
  
  
  RESULTS
  A total of 2,118 women were assigned to the GDM group (n = 639) and control group (n = 1,479). The mean level of serum GA in GDM group was significantly greater than that in the control group at both 24-28 and 36-38 weeks of gestation (P < 0.05). The area under the receiver operating characteristic curve for GA defining good glycemic control in GDM was 0.874 (95% confidence interval 0.811-0.938). The cut-off point for the GA levels derived from the receiver operating characteristic curve was 11.60%, which had sensitivity and specificity for detecting a poor glycemic status of 75.93% and 86.36%, respectively. The risk of birthweight ≥3,500 g and macrosomia increased significantly with GA levels ≥13.00% at 24-28 weeks and ≥12.00% at 36-38 weeks of gestation.
  
  
  CONCLUSIONS
  GA might be an appropriate and conveniently measured index that can detect poor glycemic control and predict birthweights in GDM women.
authors.affiliation: Department of Gynecology & Obstetrics Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.
authors.forename: Hua-Ping
authors.initials: HP
authors.lastname: Li
authors.affiliation: Department of Gynecology & Obstetrics Shenzhou City Hospital Shenzhou Hebei China.
authors.forename: Feng-Huan
authors.initials: FH
authors.lastname: Wang
authors.affiliation: Department of Gynecology & Obstetrics Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.
authors.forename: Min-Fang
authors.initials: MF
authors.lastname: Tao
authors.affiliation: Department of Gynecology & Obstetrics Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.
authors.forename: Ya-Juan
authors.initials: YJ
authors.lastname: Huang
authors.affiliation: Department of Endocrinology and Metabolism Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Jia
mesh_terms: D000328:Adult; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D017127:Glycation End Products, Advanced; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism*; D015430:Weight Gain / Q000502:physiology; D000093423:Glycated Serum Albumin
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
keywords: Birthweight; Gestational diabetes; Glycated albumin
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