title: Fabrication and Evaluation of Nanostructured Herbal Oil/Hydroxypropyl-β-Cyclodextrin/Polyvinylpyrrolidone Mats for Denture Stomatitis Prevention and Treatment.
abstract: This work aims to develop the herbal oil-incorporated nanostructure mats with antifungal activity for the prevention and treatment of Candida-associated denture stomatitis. The nanofiber mats loaded with betel oil or clove oil were fabricated via electrospinning process. The morphologies and physicochemical properties of the herbal oil loaded nanofiber mats were examined using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and mechanical testing. The release characteristic, antifungal activity, and cytotoxicity were also investigated. The SEM images confirmed the homogeneous and smooth nanoscale fibers. The addition of the herbal oil into the nanofiber mats reduced the fiber diameters. The DSC and FT-IR results confirmed the presence of the oil in the nanofiber mats. The herbal oils can be released from the mats in a very fast manner and inhibit the growth of candida cells within only few minutes after contact. These nanofiber mats may be beneficial for the prevention and treatment of denture stomatitis.
authors.affiliation: Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, NakhonPathom, Thailand.
authors.forename: Prasopchai
authors.initials: P
authors.lastname: Tonglairoum
authors.affiliation: Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, NakhonPathom, Thailand.
authors.forename: Tanasait
authors.initials: T
authors.lastname: Ngawhirunpat
authors.affiliation: Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, NakhonPathom, Thailand.
authors.forename: Theerasak
authors.initials: T
authors.lastname: Rojanarata
authors.affiliation: Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand.
authors.forename: Ruchadaporn
authors.initials: R
authors.lastname: Kaomongkolgit
authors.affiliation: Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, NakhonPathom, Thailand. opanasopit_p@su.ac.th.
authors.forename: Praneet
authors.initials: P
authors.lastname: Opanasopit
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000935:Antifungal Agents / Q000737:chemistry; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002175:Candida / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D008855:Microscopy, Electron, Scanning / Q000379:methods; D057139:Nanofibers / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D028321:Plant Preparations / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013282:Stomatitis, Denture / Q000382:microbiology / Q000517:prevention & control*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D010938:Plant Oils; D028321:Plant Preparations; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D011205:Povidone
keywords: betel oil; clove oil; hydroxypropyl-beta-cyclodextrin; nanofibers; polyvinylpyrrolidone