title: Randomized Controlled Trial of Hospital-Based Hygiene and Water Treatment Intervention (CHoBI7) to Reduce Cholera.
abstract: The risk for cholera infection is >100 times higher for household contacts of cholera patients during the week after the index patient seeks hospital care than it is for the general population. To initiate a standard of care for this high-risk population, we developed Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which promotes hand washing with soap and treatment of water. To test CHoBI7, we conducted a randomized controlled trial among 219 intervention household contacts of 82 cholera patients and 220 control contacts of 83 cholera patients in Dhaka, Bangladesh, during 2013-2014. Intervention contacts had significantly fewer symptomatic Vibrio cholerae infections than did control contacts and 47% fewer overall V. cholerae infections. Intervention households had no stored drinking water with V. cholerae and 14 times higher odds of hand washing with soap at key events during structured observation on surveillance days 5, 6, or 7. CHoBI7 presents a promising approach for controlling cholera among highly susceptible household contacts of cholera patients.
authors.forename: Christine Marie
authors.initials: CM
authors.lastname: George
authors.forename: Shirajum
authors.initials: S
authors.lastname: Monira
authors.forename: David A
authors.initials: DA
authors.lastname: Sack
authors.forename: Mahamud-ur
authors.initials: MU
authors.lastname: Rashid
authors.forename: K M
authors.initials: KM
authors.lastname: Saif-Ur-Rahman
authors.forename: Toslim
authors.initials: T
authors.lastname: Mahmud
authors.forename: Zillur
authors.initials: Z
authors.lastname: Rahman
authors.forename: Munshi
authors.initials: M
authors.lastname: Mustafiz
authors.forename: Sazzadul Islam
authors.initials: SI
authors.lastname: Bhuyian
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Winch
authors.forename: Elli
authors.initials: E
authors.lastname: Leontsini
authors.forename: Jamie
authors.initials: J
authors.lastname: Perin
authors.forename: Farzana
authors.initials: F
authors.lastname: Begum
authors.forename: Fatema
authors.initials: F
authors.lastname: Zohura
authors.forename: Shwapon
authors.initials: S
authors.lastname: Biswas
authors.forename: Tahmina
authors.initials: T
authors.lastname: Parvin
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Zhang
authors.forename: Danielle
authors.initials: D
authors.lastname: Jung
authors.forename: R Bradley
authors.initials: RB
authors.lastname: Sack
authors.forename: Munirul
authors.initials: M
authors.lastname: Alam
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001459:Bangladesh / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D005191:Family Characteristics; D005260:Female; D006761:Hospitals; D006801:Humans; D006920:Hygiene; D007223:Infant; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D014734:Vibrio cholerae / Q000302:isolation & purification; D018508:Water Purification; D055815:Young Adult
keywords: Bangladesh; bacteria; cholera; enteric infections; hand washing; household contacts; prevention; randomized controlled trial; water treatment
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