title: The use of coenzyme Q10 and DHEA during IUI and IVF cycles in patients with decreased ovarian reserve.
abstract: OBJECTIVE
  The objective of this study is to compare the combination of dehydroepiandrosterone (DHEA) and coenzyme Q10 (CoQ10) (D + C) with DHEA alone (D) in intrauterine insemination (IUI) and in vitro fertilization (IVF) cycles among patients with decreased ovarian reserve.
  
  
  METHODS
  We retrospectively extracted data from patients charts treated by DHEA with/without CoQ10 during IUI or IVF between February 2006 and June 2014. Prestimulation parameters included age, BMI, day 3 FSH and antral follicular count (AFC). Ovarian response parameters included total gonadotropins dosage, peak serum estradiol, number of follicles > 16 mm and fertilization rate. Clinical outcomes included clinical and ongoing pregnancy rates.
  
  
  RESULTS
  Three hundred and thirty IUI cycles involved D + C compared with 467 cycles of D; 78 IVF cycles involved D + C and 175 D. In both IUI and IVF, AFC was higher with D + C compared with D (7.4 ± 5.7 versus 5.9 ± 4.7, 8.2 ± 6.3 versus 5.2 ± 5, respectively, p < 0.05). D + C resulted in a more follicles > 16 mm during IUI cycles (3.3 ± 2.3 versus 2.9 ± 2.2, respectively, p = 0.01), while lower mean total gonadotropin dosage was administered after D + C supplementation compared with D (3414 ± 1141 IUs versus 3877 ± 1143 IUs respectively, p = 0.032) in IVF cycles. Pregnancy and delivery rates were similar for both IUI and IVF.
  
  
  CONCLUSIONS
  D + C significantly increases AFC and improves ovarian responsiveness during IUI and IVF without a difference in clinical outcome.
authors.affiliation: a CReATe Fertility Centre , Toronto , Canada .|b Pinchas Borenstein Talpiot Medical Leadership Program, Sheba Medical Center , Tel HaShomer , Ramat Gan , Israel .
authors.forename: Itai
authors.initials: I
authors.lastname: Gat
authors.affiliation: c Toronto West Fertility Center , Etobicoke , Canada .|d Risk Factor Modification Center, St. Michael's Hospital , Toronto , Canada .
authors.forename: Sonia
authors.initials: S
authors.lastname: Blanco Mejia
authors.affiliation: a CReATe Fertility Centre , Toronto , Canada .
authors.forename: Hanna
authors.initials: H
authors.lastname: Balakier
authors.affiliation: a CReATe Fertility Centre , Toronto , Canada .|e Department of Obstetrics & Gynecology , University of Toronto , Canada .|f Department of Physiology , University of Toronto , Canada , and.|g Department of Gynecology , Women's College Hospital , Toronto , Canada.
authors.forename: Clifford L
authors.initials: CL
authors.lastname: Librach
authors.affiliation: c Toronto West Fertility Center , Etobicoke , Canada .|e Department of Obstetrics & Gynecology , University of Toronto , Canada .
authors.forename: Anne
authors.initials: A
authors.lastname: Claessens
authors.affiliation: c Toronto West Fertility Center , Etobicoke , Canada .|e Department of Obstetrics & Gynecology , University of Toronto , Canada .
authors.forename: Edward A J
authors.initials: EA
authors.lastname: Ryan
mesh_terms: D000328:Adult; D003687:Dehydroepiandrosterone / Q000008:administration & dosage / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D012739:Gonadal Steroid Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D017063:Outcome Assessment, Health Care; D065851:Ovarian Reserve / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D012189:Retrospective Studies; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012739:Gonadal Steroid Hormones; D014815:Vitamins; D014451:Ubiquinone; D003687:Dehydroepiandrosterone; C024989:coenzyme Q10
keywords: Antral follicle count; CoQ10; DHEA; IVF; controlled ovarian hyper stimulation