title: Mesenchymal stem cells and alginate microcarriers for craniofacial bone tissue engineering: A review.
abstract: Craniofacial bone is a complex structure with an intricate anatomical and physiological architecture. The defects that exist in this region therefore require a precise control of osteogenesis in their reconstruction. Unlike traditional surgical intervention, tissue engineering techniques mediate bone development with limited postoperative risk and cost. Alginate stands as the premier polymer in bone repair because of its mild ionotropic gelation and excellent biocompatibility, biodegradability, and injectability. Alginate microcarriers are candidates of choice to mediate cells and accommodate into 3-D environment. Several studies reported the use of alginate microcarriers for delivering cells, drugs, and growth factors. This review will explore the potential use of alginate microcarrier for stem cell systems and its application in craniofacial bone tissue engineering.
authors.affiliation: Nova Southeastern University College of Dental Medicine, Fort Lauderdale, Florida, 33328.
authors.forename: Adam
authors.initials: A
authors.lastname: Saltz
authors.affiliation: Nova Southeastern University College of Dental Medicine, Fort Lauderdale, Florida, 33328.
authors.forename: Umadevi
authors.initials: U
authors.lastname: Kandalam
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry*; D002356:Cartilage / Q000166:cytology / Q000254:growth & development; D018914:Cells, Immobilized / Q000166:cytology; D016503:Drug Delivery Systems / Q000379:methods; D005147:Facial Bones / Q000166:cytology / Q000254:growth & development*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage; D008422:Materials Testing; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010012:Osteogenesis; D012212:Rheology; D012886:Skull / Q000166:cytology / Q000254:growth & development*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D000464:Alginates; D018786:Bone Substitutes; D006603:Hexuronic Acids; D036341:Intercellular Signaling Peptides and Proteins; D020723:Glucuronic Acid
keywords: MSCs; alginate; craniofacial bone tissue engineering; hydrogels; microcarriers