title: N-Acyl Dehydrotyrosines, Tyrosinase Inhibitors from the Marine Bacterium Thalassotalea sp. PP2-459.
abstract: Thalassotalic acids A-C and thalassotalamides A and B are new N-acyl dehydrotyrosine derivatives produced by Thalassotalea sp. PP2-459, a Gram-negative bacterium isolated from a marine bivalve aquaculture facility. The structures were elucidated via a combination of spectroscopic analyses emphasizing two-dimensional NMR and high-resolution mass spectrometric data. Thalassotalic acid A (1) displays in vitro inhibition of the enzyme tyrosinase with an IC50 value (130 μM) that compares favorably to the commercially used control compounds kojic acid (46 μM) and arbutin (100 μM). These are the first natural products reported from a bacterium belonging to the genus Thalassotalea.
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Deering
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.|College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou 310014, People's Republic of China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.
authors.forename: Jiadong
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.
authors.forename: Hang
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Microbiology and Parasitology, CIBUS-Faculty of Biology and Aquaculture Institute, University of Santiago de Compostela , Santiago de Compostela 17582, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Dubert
authors.affiliation: Department of Microbiology and Parasitology, CIBUS-Faculty of Biology and Aquaculture Institute, University of Santiago de Compostela , Santiago de Compostela 17582, Spain.
authors.forename: Juan L
authors.initials: JL
authors.lastname: Barja
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.
authors.forename: Navindra P
authors.initials: NP
authors.lastname: Seeram
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou 310014, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.
authors.forename: David C
authors.initials: DC
authors.lastname: Rowley
mesh_terms: D001104:Arbutin / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D020560:Proteobacteria / Q000737:chemistry*; D011753:Pyrones / Q000494:pharmacology; D013030:Spain; D014443:Tyrosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D011753:Pyrones; D014443:Tyrosine; C011890:kojic acid; D001104:Arbutin; D014442:Monophenol Monooxygenase
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