title: Amygdala activity during autobiographical memory recall as a biomarker for residual symptoms in patients remitted from depression.
abstract: We performed a linear regression analysis on demographic, memory performance, and amygdala activity during memory recall on 23 unmedicated participants remitted from major depressive disorder. Amygdala activity during positive memory recall, and the percent of specific positive memories recalled were the variables that explained the most variance in residual depressive symptoms. This model was not significant in control or currently depressed participants. Longitudinal follow up is necessary to assess whether these variables predict relapse.
authors.affiliation: Laureate Institute for Brain Research, Tulsa, OK, USA. Electronic address: kyoung@laureateinstitute.org.
authors.forename: Kymberly D
authors.initials: KD
authors.lastname: Young
authors.affiliation: Laureate Institute for Brain Research, Tulsa, OK, USA; Janssen Research and Development, LLC, of Johnson & Johnson, Inc., New Brunswick, NJ, USA.
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Drevets
authors.affiliation: Laureate Institute for Brain Research, Tulsa, OK, USA; Biomedical Engineering Center, University of Oklahoma College of Engineering, Norman, OK, USA.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Bodurka
authors.affiliation: Laureate Institute for Brain Research, Tulsa, OK, USA; University of Kansas Medical Center, Kansas City, KS, USA.
authors.forename: Sheldon S
authors.initials: SS
authors.lastname: Preskorn
mesh_terms: D000328:Adult; D000679:Amygdala / Q000503:physiopathology*; D015415:Biomarkers; D003865:Major Depressive Disorder / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D011939:Mental Recall / Q000502:physiology*; D012074:Remission Induction
chemical_list: D015415:Biomarkers
keywords: Amygdala; Autobiographical memory; Residual depressive symptoms