title: Arresting supporters: targeting neutrophils in metastasis.
abstract: It is becoming increasingly clear that leukocytes dynamically regulate cancer progression and metastasis, and among leukocytes, granulocytic cells abundantly accumulate in metastatic organs; however, their function in metastasis remains controversial. In a recent report in Nature, Wculek and Malanchi clarify the role of mature neutrophils as mediators of metastatic initiation and provide a targeted approach to prevent the pro-metastatic activity of neutrophils in breast cancer models.
authors.affiliation: Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.|Herbert Irving Comprehensive Cancer Center, New York, NY 10065, USA.
authors.forename: Swarnali
authors.initials: S
authors.lastname: Acharyya
authors.affiliation: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Joan
authors.initials: J
authors.lastname: Massague
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D008175:Lung Neoplasms / Q000473:pathology* / Q000556:secondary*; D009362:Neoplasm Metastasis / Q000473:pathology*; D009504:Neutrophils / Q000378:metabolism*
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