title: Histologic outcome of thyroid nodules with repeated diagnosis of atypia in thyroid fine-needle aspiration biopsy.
abstract: OBJECTIVE
  We hypothesized that the estimated risk of malignancy for atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is higher than anticipated in Bethesda system. Therefore, we analyzed the actual malignancy risk of repeated AUS/FLUS diagnosis of thyroid fine-needle aspiration biopsies (FNAB).
  
  
  METHODS
  We reported retrospective analyzes of 112 cases with repeated AUS/FLUS diagnosis among 10,769 thyroid FNABs. The histologic follow-up were evaluated in the study.
  
  
  RESULTS
  112 cases with a repeated diagnosis of AUS/FLUS, histologic follow-up revealed 56 (50%) benign, 46 (41%) malignant and ten (9%) well-differentiated tumors of uncertain malignant potential outcome.
  
  
  CONCLUSIONS
  The malignancy risk of AUS/FLUS category in thyroid FNABs was higher than anticipated in Bethesda system. Therefore, the management strategy of AUS/FLUS should be revised.
authors.affiliation: Department of Endocrinology & Metabolism, Kocaeli University Faculty of Medicine, Umuttepe Kocaeli, Turkey.
authors.forename: Alev
authors.initials: A
authors.lastname: Selek
authors.affiliation: Department of Endocrinology & Metabolism, Kocaeli University Faculty of Medicine, Umuttepe Kocaeli, Turkey.
authors.forename: Berrin
authors.initials: B
authors.lastname: Cetinarslan
authors.affiliation: Department of Internal Medicine, Kocaeli University Faculty of Medicine, Umuttepe Kocaeli, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Kıvrakoğlu
authors.affiliation: Department of Internal Medicine, Kocaeli University Faculty of Medicine, Umuttepe Kocaeli, Turkey.
authors.forename: Duygu Temiz
authors.initials: DT
authors.lastname: Karadağ
authors.affiliation: Department of Endocrinology & Metabolism, Kocaeli University Faculty of Medicine, Umuttepe Kocaeli, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Tarkun
authors.affiliation: Department of Endocrinology & Metabolism, Kocaeli University Faculty of Medicine, Umuttepe Kocaeli, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Canturk
authors.affiliation: Department of Endocrinology & Metabolism, Kocaeli University Faculty of Medicine, Umuttepe Kocaeli, Turkey.
authors.forename: Ozlem Zeynep
authors.initials: OZ
authors.lastname: Akyay
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012306:Risk; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000453:epidemiology*; D055815:Young Adult
keywords: thyroid atypia of undetermined significance; thyroid cancer; thyroid fine-needle aspiration biopsy; thyroid follicular lesion of undetermined significance