title: Accelerometer-determined physical activity and all-cause mortality in a national prospective cohort study of hypertensive adults.
abstract: OBJECTIVE
  Research in the general population suggests an inverse association between physical activity and all-cause mortality. Less research on this topic has been conducted among hypertensive adults, but the limited studies also suggest an inverse association between physical activity and all-cause mortality among hypertensive adults. At this point, sex-specific differences are not well understood, and all of the physical activity-mortality studies among hypertensive adults have employed a self-report measure of physical activity. Therefore, the purpose of this study was to examine the sex-specific association between objectively measured physical activity and all-cause mortality among a national sample of hypertensive adults.
  
  
  METHODS
  Data from the 2003 to 2006 National Health and Nutrition Examination Survey, with follow-up through 2011, were employed. Hypertension status was defined using measured blood pressure and use of blood pressure-lowering medication. Physical activity was assessed via accelerometry.
  
  
  RESULTS
  After adjustments, for every 60-min increase in physical activity, hypertensive adults had a 19% (hazard rate = 0.81; 95% confidence interval: 0.72-0.91) reduced risk of all-cause mortality. There was also evidence of a dose-response relationship. Compared with those in the lowest tertile, those in the middle and upper tertiles had a 31 and 42% reduced all-cause mortality risk, respectively. There was no evidence of a sex-specific interaction effect.
  
  
  CONCLUSIONS
  Among hypertensive adults, objectively measured physical activity is associated with all-cause mortality risk in a dose-response manner.
authors.affiliation: Center for Behavioral Research, Department of Health, Exercise Science, and Recreation Management, University of Mississippi, Oxford, Mississippi, USA.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Loprinzi
mesh_terms: D061725:Accelerometry; D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D015444:Exercise; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult