title: Wakayama symposium: interface between innate and adaptive immunity in dry eye disease.
abstract: Although the mechanism of dry eye disease is not clearly understood, it is certain that inflammation and the immune response play a major role in determining the health of the ocular surface in dry eye patients. Accurate ocular surface characterization during the early stages of dry eye disease is critical for successful treatment, because there exists no single standard, objective test to diagnose the early phase of dry eye disease. The treatment target should be direct to prevent the perpetuation of chronic inflammation and immune responses. Numerous studies have categorized dry eye disease as an autoimmune-related inflammatory disease. However, relatively little is known about how innate immune mechanisms act following a local insult, why some patients are particularly vulnerable, and why local inflammation fails to resolve in these patients. Within this review, particular attention will be given to the very early events and corresponding defense mechanism in dry eye disease. The transition from innate to adaptive immunity will also be discussed.
authors.affiliation: Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Kyung-Sun
authors.initials: KS
authors.lastname: Na
authors.affiliation: Department of Ophthalmology, Konyang University Hospital, Daejeon, South Korea.
authors.forename: Kyu-Yeon
authors.initials: KY
authors.lastname: Hwang
authors.affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: So-Hyang
authors.initials: SH
authors.lastname: Chung
authors.affiliation: Catholic Institutes of Visual Science, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Jee Won
authors.initials: JW
authors.lastname: Mok
authors.affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. ckjoo@catholic.ac.kr.|Catholic Institutes of Visual Science, The Catholic University of Korea, Seoul, South Korea. ckjoo@catholic.ac.kr.
authors.forename: Choun-Ki
authors.initials: CK
authors.lastname: Joo
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology*; D001327:Autoimmune Diseases / Q000276:immunology; D003226:Congresses as Topic; D003228:Conjunctiva / Q000276:immunology; D015352:Dry Eye Syndromes / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007249:Inflammation / Q000276:immunology
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