title: Clozapine-induced myoclonus: a case report and review of the literature.
abstract: We describe the case of a young man with treatment-resistant schizophrenia, who developed myoclonus during clozapine titration. This subsequently led to a full tonic-clonic seizure. Clozapine treatment can result in a range of seizure-like activity, the most well-known being tonic-clonic seizures. This case highlights the importance of recognizing and treating clozapine-induced myoclonus, as it can herald the onset of a full seizure, even at low serum clozapine levels. We highlight the variety of ways myoclonus can present clinically and suggest treatment options.
authors.affiliation: Clinical Pharmacist, Pharmacy Department, South London and Maudsley NHS Foundation Trust, The Maudsley Hospital, Denmark Hill, London, SE5 8AZ, UK.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Osborne
authors.affiliation: Consultant Psychiatrist and Honorary Senior Lecturer, South London and Maudsley NHS Foundation Trust, KCL Faculty of Life Sciences and Medicine, UK.
authors.forename: Ronan J
authors.initials: RJ
authors.lastname: McIvor
keywords: clozapine; myoclonus; seizures
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