title: The Basics of Renal Allograft Pathology.
abstract: Renal allograft biopsy provides critical information in the management of renal transplant patients, and must be analyzed in close collaboration with the clinical team. The histologic correlates of acute T-cell mediated rejection are interstitial inflammation, tubulitis, and endothelialitis; polyomavirus nephropathy is a potential mimic. Evidence of antibody-mediated rejection includes C4d deposition; morphologic acute tissue injury; and donor specific antibodies. Acute tubular injury/necrosis is a reversible cause of impaired graft function, especially in the immediate post-transplant period. Drug toxicity, recurrent disease, chronic injury, and other entities affecting both native and transplant kidneys must also be evaluated.
authors.affiliation: Department of Pathology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address: troxellm@ohsu.edu.
authors.forename: Megan L
authors.initials: ML
authors.lastname: Troxell
authors.affiliation: Department of Pathology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.
authors.forename: Donald C
authors.initials: DC
authors.lastname: Houghton
keywords: Antibody-mediated rejection; C4d; Kidney; Polyomavirus; T-cell–mediated rejection; Transplant