title: Impact of age on cytotoxic-induced ovarian failure in breast cancer treated with adjuvant chemotherapy and triptorelin.
abstract: OBJECTIVE
  This study analyzes our single-center, retrospective experience on 63 premenopausal breast cancer patients treated with monthly triptorelin and concomitant chemotherapy.
  
  
  METHODS
  Concomitant chemotherapy and triptorelin were adopted as part of premature ovarian failure prevention strategy.
  
  
  RESULTS
  Age at diagnosis was the main factor influencing fertility preservation (p = 0.002). Compared with patients aged 41-45 years, the probability of menses resumption was almost threefold than for women aged 35-40 years, and significantly higher for women aged <35 years (hazard ratio: 9.0; p = 0.0001). The cumulative proportion among patients who resumed menses was 33.3% at 6 months, 75% at 12 months and 87.5% at 24 months. Seven patients attempted pregnancy, and five (71%) obtained healthy deliveries.
  
  
  CONCLUSIONS
  We observed an acceptable rate of fertility preservation. Age at diagnosis influences fertility preservation.
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Icro
authors.initials: I
authors.lastname: Meattini
authors.affiliation: Molecular & Nutritional Epidemiology Unit, Cancer Research & Prevention Institute (ISPO), University of Florence, Florence, Italy.
authors.forename: Calogero
authors.initials: C
authors.lastname: Saieva
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Fiammetta
authors.initials: F
authors.lastname: Meacci
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Vieri
authors.initials: V
authors.lastname: Scotti
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: De Luca Cardillo
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Isacco
authors.initials: I
authors.lastname: Desideri
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Baldazzi
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Mangoni
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Scoccianti
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Detti
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Simontacchi
authors.affiliation: Diagnostic Senology Unit, University of Florence, Florence, Italy.
authors.forename: Jacopo
authors.initials: J
authors.lastname: Nori
authors.affiliation: Department of Surgery, University of Florence, Florence, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Orzalesi
authors.affiliation: Department of Surgery, University of Florence, Florence, Italy.
authors.forename: Luis
authors.initials: L
authors.lastname: Sanchez
authors.affiliation: Department of Surgery, University of Florence, Florence, Italy.
authors.forename: Donato
authors.initials: D
authors.lastname: Casella
authors.affiliation: Department of Surgery, University of Florence, Florence, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bernini
authors.affiliation: Gynecologic & Obstetrics Unit, University of Florence, Florence, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fambrini
authors.affiliation: Division of Pathological Anatomy, Department of Medical & Surgical Critical Care, University of Florence, Florence, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Bianchi
authors.affiliation: Department of Radiation Oncology, University of Florence, Florence, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Livi
mesh_terms: D000328:Adult; D000367:Age Factors; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality; D005260:Female; D059247:Fertility Preservation; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D017697:Premenopause; D016649:Primary Ovarian Insufficiency / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D017329:Triptorelin Pamoate
keywords: GnRH analogs; adjuvant treatment; breast cancer; concomitant chemotherapy; fertility preservation; premature ovarian failure; triptorelin