title: One-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a sequential isocyanide-based multicomponent/Wittig reaction.
abstract: A one-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a I-MCR/Wittig sequence was developed. The reaction of phosphonium salt , an acid, an amine (or without), and an isocyanide gave the 1H-isochromenes or 1,2-dihydroisoquinolines in good yields by a sequential Passerini or Ugi condensation and an intramolecular Wittig reaction in the presence of K2CO3.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. China. mwding@mail.ccnu.edu.cn and College of Materials and Chemical Engineering, China Three Gorges University, Yichang, Hubei 443002, P. R. China.
authors.forename: Long
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. China. mwding@mail.ccnu.edu.cn.
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Guan
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. China. mwding@mail.ccnu.edu.cn.
authors.forename: Ming-Wu
authors.initials: MW
authors.lastname: Ding
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001578:Benzopyrans; D003486:Cyanides; C109853:G 1617; D007546:Isoquinolines