title: Peroxiredoxins and the Regulation of Cell Death.
abstract: Cell death pathways such as apoptosis can be activated in response to oxidative stress, enabling the disposal of damaged cells. In contrast, controlled intracellular redox events are proposed to be a significant event during apoptosis signaling, regardless of the initiating stimulus. In this scenario oxidants act as second messengers, mediating the post-translational modification of specific regulatory proteins. The exact mechanism of this signaling is unclear, but increased understanding offers the potential to promote or inhibit apoptosis through modulating the redox environment of cells. Peroxiredoxins are thiol peroxidases that remove hydroperoxides, and are also emerging as important players in cellular redox signaling. This review discusses the potential role of peroxiredoxins in the regulation of apoptosis, and also their ability to act as biomarkers of redox changes during the initiation and progression of cell death.
authors.affiliation: Centre for Free Radical Research, Department of Pathology, University of Otago, Christchurch 8140, New Zealand.
authors.forename: Mark B
authors.initials: MB
authors.lastname: Hampton
authors.affiliation: Centre for Free Radical Research, Department of Pathology, University of Otago, Christchurch 8140, New Zealand.
authors.forename: Karina M
authors.initials: KM
authors.lastname: O'Connor
mesh_terms: D000818:Animals; D017209:Apoptosis; D006801:Humans; D016877:Oxidants / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D054464:Peroxiredoxins / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
chemical_list: D016877:Oxidants; D054464:Peroxiredoxins
keywords: apoptosis; hydrogen peroxide; mitochondria; peroxiredoxins; redox signaling
references.citation: Br J Cancer. 2013 Aug 20;109(4):983-93
references.pmid: 23880827
references.citation: Blood. 2003 Jun 15;101(12):5033-8
references.pmid: 12586629
references.citation: Anticancer Res. 2002 Nov-Dec;22(6A):3331-5
references.pmid: 12530083
references.citation: Nat Chem Biol. 2005 Sep;1(4):223-32
references.pmid: 16408039
references.citation: Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8115-9
references.pmid: 7667254
references.citation: Proc Natl Acad Sci U S A. 2002 May 14;99(10):6649-54
references.pmid: 12011429
references.citation: Biomed Rep. 2013 Mar;1(2):228-230
references.pmid: 24648924
references.citation: Free Radic Biol Med. 2005 Jun 15;38(12):1543-52
references.pmid: 15917183
references.citation: Free Radic Biol Med. 2008 Aug 15;45(4):494-502
references.pmid: 18501718
references.citation: Biochemistry. 2002 Apr 30;41(17):5493-504
references.pmid: 11969410
references.citation: FASEB J. 2005 Sep;19(11):1504-6
references.pmid: 15972297
references.citation: Trends Biochem Sci. 2003 Jan;28(1):32-40
references.pmid: 12517450
references.citation: Oncol Lett. 2012 Jun;3(6):1275-1279
references.pmid: 22783432
references.citation: Cell. 2002 Nov 15;111(4):471-81
references.pmid: 12437921
references.citation: Immunity. 2013 Sep 19;39(3):443-53
references.pmid: 24012422
references.citation: Cell. 2012 Jan 20;148(1-2):213-27
references.pmid: 22265413
references.citation: J Biol Chem. 2004 Mar 12;279(11):10822-8
references.pmid: 14701813
references.citation: J Biol Chem. 1997 Dec 5;272(49):30615-8
references.pmid: 9388194
references.citation: Nat Chem Biol. 2015 Jan;11(1):64-70
references.pmid: 25402766
references.citation: Free Radic Biol Med. 2007 Feb 1;42(3):326-34
references.pmid: 17210445
references.citation: DNA Cell Biol. 1997 Mar;16(3):311-21
references.pmid: 9115640
references.citation: PLoS One. 2015;10(5):e0127310
references.pmid: 26011724
references.citation: Oncotarget. 2016 Jan 12;7(2):1717-31
references.pmid: 26636537
references.citation: FEBS Lett. 2000 Jun 30;476(1-2):52-4
references.pmid: 10878249
references.citation: Respirology. 2006 May;11(3):269-75
references.pmid: 16635084
references.citation: Biochemistry. 2009 Jul 14;48(27):6495-501
references.pmid: 19462976
references.citation: Free Radic Biol Med. 2016 Feb;91:81-92
references.pmid: 26686468
references.citation: Mol Cell. 2007 Jun 8;26(5):675-87
references.pmid: 17560373
references.citation: J Am Soc Mass Spectrom. 2011 May;22(5):888-97
references.pmid: 21472523
references.citation: J Pathol. 2002 Mar;196(3):316-23
references.pmid: 11857495
references.citation: Mol Cell. 2002 Feb;9(2):387-99
references.pmid: 11864611
references.citation: EMBO J. 2003 Jul 1;22(13):3356-66
references.pmid: 12839997
references.citation: Free Radic Biol Med. 2012 Oct 1;53(7):1522-30
references.pmid: 22902630
references.citation: Nature. 2003 Jul 31;424(6948):561-5
references.pmid: 12891360
references.citation: Mol Cancer Res. 2003 Jul;1(9):682-9
references.pmid: 12861054
references.citation: Nat Chem Biol. 2012 May;8(5):486-93
references.pmid: 22484541
references.citation: Oncol Rep. 2015 Mar;33(3):1427-33
references.pmid: 25607351
references.citation: Biochem Biophys Res Commun. 2007 Apr 13;355(3):715-21
references.pmid: 17316558
references.citation: Biochemistry. 2005 Aug 9;44(31):10583-92
references.pmid: 16060667
references.citation: Nat Chem Biol. 2008 May;4(5):278-86
references.pmid: 18421291
references.citation: Free Radic Biol Med. 2008 Mar 15;44(6):1001-9
references.pmid: 18164270
references.citation: Tumour Biol. 2013 Aug;34(4):2275-81
references.pmid: 23564483
references.citation: Mol Cell. 2014 Apr 10;54(1):133-46
references.pmid: 24703947
references.citation: Free Radic Biol Med. 2006 Mar 15;40(6):968-75
references.pmid: 16540392
references.citation: J Biol Chem. 2001 Jun 15;276(24):21870-7
references.pmid: 11285261
references.citation: FEBS Lett. 1997 Sep 15;414(3):552-6
references.pmid: 9323034
references.citation: Nat Chem Biol. 2005 Jul;1(2):112-9
references.pmid: 16408008
references.citation: Cell. 1997 Nov 14;91(4):443-6
references.pmid: 9390553
references.citation: Biochem Biophys Res Commun. 2001 Mar 23;282(1):329-33
references.pmid: 11264011
references.citation: Nat Rev Mol Cell Biol. 2014 Feb;15(2):135-47
references.pmid: 24452471
references.citation: J Biol Chem. 1992 Mar 15;267(8):5317-23
references.pmid: 1312087
references.citation: J Biol Chem. 2004 Oct 1;279(40):41975-84
references.pmid: 15280382
references.citation: Biochem J. 2010 Jan 15;425(2):313-25
references.pmid: 20025614
references.citation: Science. 2003 Apr 25;300(5619):650-3
references.pmid: 12714747
references.citation: Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4497-502
references.pmid: 22393005
references.citation: Arch Biochem Biophys. 2007 Sep 1;465(1):119-26
references.pmid: 17548047
references.citation: Structure. 2015 May 5;23(5):912-20
references.pmid: 25914057
references.citation: J Cell Biol. 2006 Oct 23;175(2):225-35
references.pmid: 17060495
references.citation: Cell. 2004 May 28;117(5):625-35
references.pmid: 15163410
references.citation: Biochim Biophys Acta. 2014 Feb;1840(2):906-12
references.pmid: 23939310
references.citation: FEBS Lett. 2002 Apr 24;517(1-3):229-32
references.pmid: 12062443
references.citation: Anticancer Res. 2001 May-Jun;21(3B):2085-90
references.pmid: 11497302
references.citation: Free Radic Biol Med. 2008 Sep 1;45(5):549-61
references.pmid: 18544350
references.citation: Biochem Pharmacol. 2008 Oct 30;76(9):1097-109
references.pmid: 18789312
references.citation: J Biol Chem. 2007 Apr 20;282(16):11885-92
references.pmid: 17329258
references.citation: Science. 1998 Aug 28;281(5381):1322-6
references.pmid: 9735050