title: Potential Biosignificant Interest and Surface Activity of Efficient Heterocyclic Derivatives.
abstract: Some functionalized pyridine and fused system derivatives were synthesized using enaminonitrile derivative 5 as a starting material for the reaction, with various reagents under different conditions. Propoxylation of these compounds using different moles of propylene oxide (3, 5 and 7 moles) leads to a novel group of surface active agents. The antimicrobial and surface activities of the synthesized compounds were investigated. Most of the evaluated compounds proved to be active as antibacterial and antifungal agents and showed good surface activity, which makes them suitable for diverse applications such as the manufacturing of emulsifiers, cosmetics, drugs, pesticides, etc. Additionally, biodegradation testing exhibits significant breakdown within six to seven days, and hence, lowers the toxicity to human beings and becomes environmentally friendly.
authors.affiliation: Chemistry Department, College of Applied Sciences, Umm Al-Qura University.
authors.forename: Refat
authors.initials: R
authors.lastname: El-Sayed
authors.forename: Ismail
authors.initials: I
authors.lastname: Althagafi
mesh_terms: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001673:Biodegradation, Environmental; D003358:Cosmetics; D045703:Emulsifying Agents; D004852:Epoxy Compounds / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D010575:Pesticides; D004364:Pharmaceutical Preparations; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003358:Cosmetics; D045703:Emulsifying Agents; D004852:Epoxy Compounds; D006571:Heterocyclic Compounds; D006574:Heterocyclic Compounds, 2-Ring; D007202:Indicators and Reagents; D009570:Nitriles; D010575:Pesticides; D004364:Pharmaceutical Preparations; D011725:Pyridines; D013501:Surface-Active Agents; C547711:enaminonitrile; C009068:propylene oxide