title: [Characteristic of blood pressure profile in elderly hypertensive patients with chronic kidney disease: a tertiary hospital-based study].
abstract: OBJECTIVE
  To identify the characteristics of blood pressure (BP) in the elderly hypertensive patients with chronic kidney disease (CKD).
  
  
  METHODS
  We retrospectively recruited 337 CKD patients who had been admitted into our renal unit during January 2010 to December 2012 and undergone clinical blood pressure (CBP) and ambulatory blood pressure (ABP) measurement with detailed clinical data. Those with age ≥ 60 years old (n = 94) were designated as elderly patients and their BP data were compared with those of young- and middle-aged patients (< 60 years old, n = 243). Logistic regression was adopted to analyze the independent risk factor for white-coat hypertension and reverse-dipper rhythm.
  
  
  RESULTS
  Compared to those < 60 y, the elder CKD patients had the following characteristics: (1) Higher prevalence of white-coat hypertension (24.5% vs 12.3%, P = 0.008). (2) Significantly lower diastolic blood pressure of average 24 h, daytime and nighttime by ambulatory monitoring of blood pressure (ABPM) (all P < 0.001). (3) Higher BP variability with significant difference (all P < 0.05) and more patients with morning surge (11.7% vs 3.7%, P = 0.009). (4) Higher prevalence of reverse-dipper circadian BP rhythm (41.5% vs 25.1%, P = 0.004). (5) Age was an independent predictor for white-coat hypertension (OR = 1.024, 95% CI: 1.004-1.044) and reverse-dipper circadian BP rhythm (OR = 1.016, 95% CI: 1.001-1.032).
  
  
  CONCLUSIONS
  The BP profile of elderly hypertensive CKD patients is different from that of young- and middle-aged patients. ABPM should be more commonly performed to improve BP treatment of elderly CKD patients.
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing 100034, China.
authors.forename: Shixing
authors.initials: S
authors.lastname: Ma
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing 100034, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing 100034, China; Email: wangyu3@medmail.com.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D006801:Humans; D006973:Hypertension; D008875:Middle Aged; D015995:Prevalence; D051436:Renal Insufficiency, Chronic; D012189:Retrospective Studies; D012307:Risk Factors; D062606:Tertiary Care Centers