title: To Establish Bethesda System for Diagnosis of Thyroid Nodules on the Basis of Fnac with Histopathological Correlation.
abstract: BACKGROUND
  In October 2007, "The National Cancer Institute (NCI), Thyroid Fine Needle Aspiration State of the Science Conference" was held in Bethesda, Maryland hosted by the NCI with the intention of formulating internationally acceptable guidelines for reporting of thyroid cytopathology. This was because, thyroid FNAC have a reporting confusion due to multiplicity of category terminologies. To overcome this, The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was introduced for unifying the terminology and morphologic criteria along with the corresponding risk of malignancy. The Bethesda system for reporting thyroid cytopathology represents a major step towards standardization, reproducibility, improved clinical significance, and greater predictive value of thyroid fine needle aspirates (FNAs).
  
  
  OBJECTIVE
  The aim of this study was to elucidate the diagnostic utility of the Bethesda system in reporting thyroid FNAs and to assess the effectiveness of FNAC in the evaluation of thyroid nodules by comparing the results with histopathological evaluation.
  
  
  METHODS
  The present study was carried out in our institute during the July 2012 to September 2014. In this study, 100 FNACs done which were classified according to the Bethesda system and out of them, 60 histopathological evaluations obtained from this group were evaluated. The sensitivity, specificity, positive and negative predictive values were evaluated.
  
  
  RESULTS
  Out of 100 FNACs, 06% were Non-diagnostic, 78% were Benign, 04% were Atypical follicular lesion of undetermined significance (AFLUS), 04% were suspicious for Follicular neoplasm (SFN), 01% were suspicious for Follicular neoplasm Hurthle cell type, 03% were suspicious for malignancy (SM), and 04% malignant. In 60 cases, data of follow-up histopathologic examination (HPE) were available. The sensitivity was 88.89% and specificity was 84.31%. The positive and negative predictive value were 50% and 97.7%, respectively.
  
  
  CONCLUSIONS
  The Bethesda system is very useful for a standardized system of reporting thyroid cytopathology, improving communication between cytopathologists and clinicians, and inter-laboratory agreement, leading to more consistent management approaches. An additional point which is in favor of the implementation of this system is that the classification is directly related to the risk of malignancy in each category, which in turn, prompts the recommended clinical management of that category, thus truly embodying the clinico-pathological correlation in its true spirit. The correlation of FNAC with histopathology is necessary before starting treatment.
authors.affiliation: Assistant Professor, Department of Pathology, Gujarat Adani Institude of Medical Science , Bhuj, Gujarat, India .
authors.forename: Sameep
authors.initials: S
authors.lastname: Garg
authors.affiliation: Professor, Department of Pathology, Shri M.P. Shah Medical College , Jamnagar, Gujarat, India .
authors.forename: Nandini J
authors.initials: NJ
authors.lastname: Desai
authors.affiliation: Assistant Professor, Department of Pathology, Shri M.P. Shah Medical College , Jamnagar, Gujarat, India .
authors.forename: Dimple
authors.initials: D
authors.lastname: Mehta
authors.affiliation: Assistant Professor, Department of Pathology, Gujarat Adani Institude of Medical Science , Bhuj, Gujarat, India .
authors.forename: Mitsu
authors.initials: M
authors.lastname: Vaishnav
keywords: Fine needle aspiration cytology; Predictive value; Sensitivity; Specificity
references.citation: J Cytol. 2014 Apr;31(2):73-8
references.pmid: 25210233
references.citation: Am J Clin Pathol. 2010 Sep;134(3):450-6
references.pmid: 20716802
references.citation: Cancer. 2007 Oct 25;111(5):306-15
references.pmid: 17680588
references.citation: Int J Health Sci (Qassim). 2012 Jun;6(2):159-73
references.pmid: 23579269
references.citation: Cancer. 1986 Mar 15;57(6):1164-70
references.pmid: 3943039
references.citation: J Cytol. 2013 Apr;30(2):94-9
references.pmid: 23833397
references.citation: Cancer. 2009 Jun 25;117(3):195-202
references.pmid: 19382174
references.citation: Am J Clin Pathol. 2009 Nov;132(5):658-65
references.pmid: 19846805
references.citation: Cancer. 2007 Dec 25;111(6):508-16
references.pmid: 17999413
references.citation: Patholog Res Int. 2015;2015:240505
references.pmid: 25688327
references.citation: J Thyroid Res. 2010 Apr 18;2010:379051
references.pmid: 21048838