title: Feeding the germline.
abstract: Nucleotides are required in order to replicate DNA in the developing germline. Here, Chi and colleagues (pp. 307-320) have used Caernohabditis elegans to identify a GLP-1-dependent checkpoint that senses food (bacterially)-supplied nucleotide levels, arresting reproductive development in the absence of sufficient nucleotide supplies.
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
authors.forename: Cheng
authors.initials: C
authors.lastname: Shi
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
authors.forename: Coleen T
authors.initials: CT
authors.lastname: Murphy
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D009711:Nucleotides / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D009711:Nucleotides; D051880:Receptors, Notch; D052216:Glucagon-Like Peptide 1
keywords: CRP; HT115; cytR; gld-1; nucleotide salvage pathway; nutrient sensing
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