title: Maximum likelihood positioning and energy correction for scintillation detectors.
abstract: An algorithm for determining the crystal pixel and the gamma ray energy with scintillation detectors for PET is presented. The algorithm uses Likelihood Maximisation (ML) and therefore is inherently robust to missing data caused by defect or paralysed photo detector pixels. We tested the algorithm on a highly integrated MRI compatible small animal PET insert. The scintillation detector blocks of the PET gantry were built with the newly developed digital Silicon Photomultiplier (SiPM) technology from Philips Digital Photon Counting and LYSO pixel arrays with a pitch of 1 mm and length of 12 mm. Light sharing was used to readout the scintillation light from the 30 × 30 scintillator pixel array with an 8 × 8 SiPM array. For the performance evaluation of the proposed algorithm, we measured the scanner's spatial resolution, energy resolution, singles and prompt count rate performance, and image noise. These values were compared to corresponding values obtained with Center of Gravity (CoG) based positioning methods for different scintillation light trigger thresholds and also for different energy windows. While all positioning algorithms showed similar spatial resolution, a clear advantage for the ML method was observed when comparing the PET scanner's overall single and prompt detection efficiency, image noise, and energy resolution to the CoG based methods. Further, ML positioning reduces the dependence of image quality on scanner configuration parameters and was the only method that allowed achieving highest energy resolution, count rate performance and spatial resolution at the same time.
authors.affiliation: Philips Research Europe, Oncology Solutions, 5656 AE Eindhoven, The Netherlands.
authors.forename: Christoph W
authors.initials: CW
authors.lastname: Lerche
authors.forename: André
authors.initials: A
authors.lastname: Salomon
authors.forename: Benjamin
authors.initials: B
authors.lastname: Goldschmidt
authors.forename: Sarah
authors.initials: S
authors.lastname: Lodomez
authors.forename: Björn
authors.initials: B
authors.lastname: Weissler
authors.forename: Torsten
authors.initials: T
authors.lastname: Solf
mesh_terms: D000465:Algorithms; D000818:Animals; D005720:Gamma Rays; D006801:Humans; D008027:Light; D017785:Photons; D049268:Positron-Emission Tomography / Q000379:methods; D012588:Scintillation Counting / Q000295:instrumentation / Q000379:methods* / Q000592:standards