title: Maternal Obesity: Lifelong Metabolic Outcomes for Offspring from Poor Developmental Trajectories During the Perinatal Period.
abstract: The prevalence of obesity in women of reproductive age is increasing in developed and developing countries around the world. Human and animal studies indicate that maternal obesity adversely impacts both maternal health and offspring phenotype, predisposing them to chronic diseases later in life including obesity, dyslipidemia, type 2 diabetes mellitus, and hypertension. Several mechanisms act together to produce these adverse health effects including programming of hypothalamic appetite-regulating centers, increasing maternal, fetal and offspring glucocorticoid production, changes in maternal metabolism and increasing maternal oxidative stress. Effective interventions during human pregnancy are needed to prevent both maternal and offspring metabolic dysfunction due to maternal obesity. This review addresses the relationship between maternal obesity and its negative impact on offspring development and presents some maternal intervention studies that propose strategies to prevent adverse offspring metabolic outcomes.
authors.affiliation: Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., México. Electronic address: zamgon@unam.mx.
authors.forename: Elena
authors.initials: E
authors.lastname: Zambrano
authors.affiliation: Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., México.
authors.forename: Carlos
authors.initials: C
authors.lastname: Ibáñez
authors.affiliation: Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., México.
authors.forename: Paola M
authors.initials: PM
authors.lastname: Martínez-Samayoa
authors.affiliation: Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., México.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Lomas-Soria
authors.affiliation: Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., México.
authors.forename: Marta
authors.initials: M
authors.lastname: Durand-Carbajal
authors.affiliation: Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., México.
authors.forename: Guadalupe L
authors.initials: GL
authors.lastname: Rodríguez-González
mesh_terms: D000818:Animals; D001066:Appetite; D002908:Chronic Disease; D005260:Female; D005938:Glucocorticoids / Q000096:biosynthesis; D006801:Humans; D008659:Metabolic Diseases / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D008661:Metabolism, Inborn Errors / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D009035:Mothers; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology*; D018384:Oxidative Stress; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D005938:Glucocorticoids
keywords: Developmental programming; Dietary intervention; Fetal programming; Maternal obesity; Metabolic syndrome; Offspring phenotype