title: Relationship between CIP2A expression, and prognosis and MDR-related proteins in patients with advanced gastric cancer.
abstract: CIP2A is highly expressed in a variety of malignancies. We determined the expression and clinical significance of CIP2A in patients with advanced gastric cancer. CIP2A protein was expressed in 25 of 37 cancer tissue specimens. There was no correlation between CIP2A and PGP, GST-π, Topo-II, and LRP expression. Survival analysis showed significant differences between the survival rate of the CIP2A protein-positive and -negative groups (χ(2)=4.509, P=0.034), but the degree of positive expression was unrelated to survival time (χ(2)=4.639, P=0.098). CIP2A expression may have no prospective value for optimizing chemotherapy regimens, but it can be an indicator for patient prognosis.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University Wenzhou, China.
authors.forename: Jian-Shi
authors.initials: JS
authors.lastname: Chen
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital, Wenzhou Medical University Wenzhou, China.
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Wu
authors.affiliation: Department of General Surgery, The First Affiliated Hospital, Wenzhou Medical University Wenzhou, China.
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Bao
authors.affiliation: School of Laboratory Medicine, Wenzhou Medical University Wenzhou, China.
authors.forename: Ji-Mei
authors.initials: JM
authors.lastname: Du
authors.affiliation: Department of General Surgery, Yichang Central People's Hospital, Three Gorges University Yichang, China.
authors.forename: Sheng-Chu
authors.initials: SC
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, The First Affiliated Hospital, Wenzhou Medical University Wenzhou, China.
authors.forename: Yi-Hu
authors.initials: YH
authors.lastname: Zheng
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000032:analysis / Q000096:biosynthesis*; D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D001324:Autoantigens / Q000032:analysis / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D053208:Kaplan-Meier Estimate; D008297:Male; D008565:Membrane Proteins / Q000032:analysis / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D001324:Autoantigens; D014408:Biomarkers, Tumor; C500266:CIP2A protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins
keywords: CIP2A; Gastric cancer; Helicobacter pylori; MRD; p53; survival time
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