title: Comparison of the Estimated Glomerular Filtration Rate (eGFR) in Diabetic Patients, Non-Diabetic Patients and Living Kidney Donors.
abstract: OBJECTIVE
  We have reported that the eGFR overestimates renal function when glycemic control is poor. It has been reported that eGFR calculated by serum creatinine underestimates GFR in living kidney donors. We compared the utility of the eGFR in diabetic patients, non-diabetic patients and living kidney donors. Forty diabetic patients, 40 non-diabetic patients, and 40 living kidney donors were enrolled.
  
  
  METHODS
  GFR was measured by inulin clearance (C(in)). eGFR was calculated based on serum creatinine (eGFR(cr)) or serum cystatin C (eGFR(cys)). We compared the agreements between each of the eGFR and C(in) in each group.
  
  
  RESULTS
  There were significant and positive correlations between each eGFR and C(in) in diabetic patients and non-diabetic patients. However, the intraclass correlation coefficients (ICC) between each eGFR and C(in) in diabetic patients (ICC: eGFR(cr) 0.699, eGFR(cys) 0.604) were weaker than those in non-diabetic patients (ICC: eGFR(cr) 0.865, eGFR(cys) 0.803). The correlation coefficients between each eGFR and C(in) (eGFR(cr); r = 0.422, p = 0.0067 and eGFR(cys); r = 0.358, p = 0.0522) in living kidney donors were significantly weaker than those in non-diabetic patients. The ICCs between each eGFR and C(in) (ICC: eGFR(cr) 0.340, eGFR(cys) 0.345) in living kidney donors were significantly weaker than those in non-diabetic patients.
  
  
  CONCLUSIONS
  Based on C(in), eGFR was accurate in non-diabetic patients. However, eGFR was inaccurate in living kidney donors and relatively inaccurate in diabetic patients.
authors.affiliation: Department of Nephrology, Department of Metabolism, Endocrinology and Molecular Medicine, Osaka, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tsuda
authors.forename: Eiji
authors.initials: E
authors.lastname: Ishimura
authors.forename: Hideki
authors.initials: H
authors.lastname: Uedono
authors.forename: Mari
authors.initials: M
authors.lastname: Yasumoto
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ichii
authors.forename: Shinya
authors.initials: S
authors.lastname: Nakatani
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Mori
authors.forename: Junji
authors.initials: J
authors.lastname: Uchida
authors.forename: Masanori
authors.initials: M
authors.lastname: Emoto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakatani
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inaba
mesh_terms: D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests / Q000592:standards*; D016030:Kidney Transplantation / Q000592:standards*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results