title: Miniature Swine for Preclinical Modeling of Complexities of Human Disease for Translational Scientific Discovery and Accelerated Development of Therapies and Medical Devices.
abstract: Noncommunicable diseases, including cardiovascular disease, diabetes, chronic respiratory disease, and cancer, are the leading cause of death in the world. The cost, both monetary and time, of developing therapies to prevent, treat, or manage these diseases has become unsustainable. A contributing factor is inefficient and ineffective preclinical research, in which the animal models utilized do not replicate the complex physiology that influences disease. An ideal preclinical animal model is one that responds similarly to intrinsic and extrinsic influences, providing high translatability and concordance of preclinical findings to humans. The overwhelming genetic, anatomical, physiological, and pathophysiological similarities to humans make miniature swine an ideal model for preclinical studies of human disease. Additionally, recent development of precision gene-editing tools for creation of novel genetic swine models allows the modeling of highly complex pathophysiology and comorbidities. As such, the utilization of swine models in early research allows for the evaluation of novel drug and technology efficacy while encouraging redesign and refinement before committing to clinical testing. This review highlights the appropriateness of the miniature swine for modeling complex physiologic systems, presenting it as a highly translational preclinical platform to validate efficacy and safety of therapies and devices.
authors.affiliation: Biomedical & Genomic Research Group, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Dominic T
authors.initials: DT
authors.lastname: Schomberg
authors.affiliation: Alizée Pathology, LLC, Thurmont, Maryland, USA.
authors.forename: Armando
authors.initials: A
authors.lastname: Tellez
authors.affiliation: Biomedical & Genomic Research Group, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Meudt
authors.affiliation: Alizée Pathology, LLC, Thurmont, Maryland, USA.
authors.forename: Dane A
authors.initials: DA
authors.lastname: Brady
authors.affiliation: Alizée Pathology, LLC, Thurmont, Maryland, USA.
authors.forename: Krista N
authors.initials: KN
authors.lastname: Dillon
authors.affiliation: Biomedical & Genomic Research Group, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Folagbayi K
authors.initials: FK
authors.lastname: Arowolo
authors.affiliation: Alizée Pathology, LLC, Thurmont, Maryland, USA.
authors.forename: Joan
authors.initials: J
authors.lastname: Wicks
authors.affiliation: Alizée Pathology, LLC, Thurmont, Maryland, USA.
authors.forename: Serge D
authors.initials: SD
authors.lastname: Rousselle
authors.affiliation: Biomedical & Genomic Research Group, University of Wisconsin-Madison, Madison, Wisconsin, USA dshanmug@wisc.edu.
authors.forename: Dhanansayan
authors.initials: D
authors.lastname: Shanmuganayagam
mesh_terms: D000818:Animals; D055808:Drug Discovery; D004864:Equipment and Supplies; D006801:Humans; D013552:Swine; D013556:Swine, Miniature / Q000276:immunology*; D057170:Translational Research, Biomedical
keywords: animal models; drug development; medical devices; mini-swine; miniature pig; minipig; pathobiology; pig; porcine; preclinical research and development; swine; transgenic animals