title: Association between continuous positive airway pressure and circulating omentin levels in patients with obstructive sleep apnoea.
abstract: OBJECTIVE
  Inflammation and oxidative stress play important roles in the pathogenesis of obstructive sleep apnoea syndrome (OSAS). Omentin is expressed in visceral adipose tissue and is associated with the inflammatory response. The aim of this study was to assess the relationship between OSAS and omentin based on a comparison of its serum levels at baseline and after 3 months of continuous positive airway pressure (CPAP) therapy.
  
  
  METHODS
  Ninety-six newly diagnosed OSAS patients and 31 non-apnoeic controls were enrolled in this study. Blood samples were obtained in the morning after polysomnography. Within the OSAS group, 30 patients were started on CPAP therapy and then reassessed clinically, including a blood test for serum omentin and other biochemical analysis, at 3 months.
  
  
  RESULTS
  Serum omentin levels were significantly lower in the OSAS group than in the control group (27.7 ± 7.6 and 42.5 ± 5.2 ng/mL, P < 0.001). In the subgroup analysis, omentin concentrations were significantly lower in patients with severe OSAS than in those with mild/moderate OSAS (P < 0.001). Circulating omentin levels were significantly correlated with the apnoea-hypopnoea index (AHI), mean SaO2, oxygen desaturation index, and serum C-reactive protein levels. Treatment with CPAP resulted in a significant increase in circulating omentin levels after 3 months, from 22.7 ± 1.4 to 41.2 ± 3.3 ng/mL (P < 0.001).
  
  
  CONCLUSIONS
  OSAS is associated with low serum omentin levels, and these levels can be reversed by effective CPAP treatment.
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, Kozlu/Zonguldak, 67600, Turkey. dr.fuygur@hotmail.com.
authors.forename: Firat
authors.initials: F
authors.lastname: Uygur
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, Kozlu/Zonguldak, 67600, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Tanrıverdi
authors.affiliation: Faculty of Medicine, Department of Biochemistry, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Can
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, Kozlu/Zonguldak, 67600, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Erboy
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, Kozlu/Zonguldak, 67600, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Altınsoy
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, Kozlu/Zonguldak, 67600, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Atalay
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, Kozlu/Zonguldak, 67600, Turkey.
authors.forename: Tacettin
authors.initials: T
authors.lastname: Ornek
authors.affiliation: Faculty of Medicine, Department of Otolaryngology, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Damar
authors.affiliation: Faculty of Medicine, Department of Biostatistics, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Furuzan
authors.initials: F
authors.lastname: Kokturk
authors.affiliation: Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, Kozlu/Zonguldak, 67600, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Tor
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D016207:Cytokines / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy*
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D002097:C-Reactive Protein; D010100:Oxygen
keywords: Cardiovascular diseases; Continuous positive airway pressure; Inflammation; Obstructive sleep apnoea syndrome; Omentin
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