title: Investigation of the combined effect of MgO and PEG on the release profile of mefenamic acid prepared via hot-melt extrusion techniques.
abstract: This study aimed to investigate the combined effect of magnesium oxide (MgO) as an alkalizer and polyethylene glycol (PEG) as a plasticizer and wetting agent in the presence of Kollidon® 12 PF and 17 PF polymer carriers on the release profile of mefenamic acid (MA), which was prepared via hot-melt extrusion technique. Various drug loads of MA and various ratios of the polymers, PEG 3350 and MgO were blended using a V-shell blender and extruded using a twin-screw extruder (16-mm Prism EuroLab, ThermoFisher Scientific, Carlsbad, CA) at different screw speeds and temperatures to prepare a solid dispersion system. Differential scanning calorimetry and X-ray diffraction data of the extruded material confirmed that the drug existed in the amorphous form, as evidenced by the absence of corresponding peaks. MgO and PEG altered the micro-environmental pH to be more alkaline (pH 9) and increased the hydrophilicity and dispersibility of the extrudates to enhance MA solubility and release, respectively. The in vitro release study demonstrated an immediate release for 2 h with more than 80% drug release within 45 min in matrices containing MgO and PEG in combination with polyvinylpyrrolidone when compared to the binary mixture, physical mixture and pure drug.
authors.affiliation: a Department of Pharmaceutics and Drug Delivery , School of Pharmacy, The University of Mississippi, University , MS , USA.
authors.forename: Sultan M
authors.initials: SM
authors.lastname: Alshehri
authors.affiliation: a Department of Pharmaceutics and Drug Delivery , School of Pharmacy, The University of Mississippi, University , MS , USA.
authors.forename: Roshan V
authors.initials: RV
authors.lastname: Tiwari
authors.affiliation: b Department of Pharmaceutics , College of Pharmacy, Prince Sattam Bin Abdulaziz University , Alkharj , Saudi Arabia.
authors.forename: Bader B
authors.initials: BB
authors.lastname: Alsulays
authors.affiliation: a Department of Pharmaceutics and Drug Delivery , School of Pharmacy, The University of Mississippi, University , MS , USA.
authors.forename: Eman A
authors.initials: EA
authors.lastname: Ashour
authors.affiliation: b Department of Pharmaceutics , College of Pharmacy, Prince Sattam Bin Abdulaziz University , Alkharj , Saudi Arabia.
authors.forename: Abdullah S
authors.initials: AS
authors.lastname: Alshetaili
authors.affiliation: a Department of Pharmaceutics and Drug Delivery , School of Pharmacy, The University of Mississippi, University , MS , USA.
authors.forename: Bjad
authors.initials: B
authors.lastname: Almutairy
authors.affiliation: c College of Pharmacy, Sahm Yook University , Seoul , Korea.
authors.forename: Jun-Bom
authors.initials: JB
authors.lastname: Park
authors.affiliation: a Department of Pharmaceutics and Drug Delivery , School of Pharmacy, The University of Mississippi, University , MS , USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Morott
authors.affiliation: d Department of Chemistry , Kansas State University , Manhattan , KS , USA , and.
authors.forename: Bhupinder
authors.initials: B
authors.lastname: Sandhu
authors.affiliation: a Department of Pharmaceutics and Drug Delivery , School of Pharmacy, The University of Mississippi, University , MS , USA.
authors.forename: Soumyajit
authors.initials: S
authors.lastname: Majumdar
authors.affiliation: a Department of Pharmaceutics and Drug Delivery , School of Pharmacy, The University of Mississippi, University , MS , USA.|e Pii Center for Pharmaceutical Technology, School of Pharmacy, The University of Mississippi, University , MS , USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Repka
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D006358:Hot Temperature; D008277:Magnesium Oxide; D008528:Mefenamic Acid; D011092:Polyethylene Glycols; D012995:Solubility
chemical_list: D004337:Drug Carriers; D008528:Mefenamic Acid; D008277:Magnesium Oxide; D011092:Polyethylene Glycols
keywords: Hot-melt extrusion; Kollidon® 12 PF and 17 PF; magnesium oxide; mefenamic acid; polyethylene glycol
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