title: [EFFECT OF INTACT BIONANOSTRUCTURES--LIPOSOMES ON BIOCHEMICAL AND IMMUNOLOGICAL STATUS OF THE ORGANISM].
abstract: Due to features of its structure and biological properties, liposomes became not only a useful model for study of cell membranes of various organs and tissues, but also unique transporters of drugs and vaccines in the organism. At the same time, biological effect on humans and animals of the preparations included into them significantly increases. An increasingly wider use of liposomes in medicine, biology and certain adjacent specialties necessitates further studies of their effect on macroorganism, generalization, systematization and analysis of already available data. Questions of effect of intact and "empty" liposomes on biochemical and immunological parameters of the organism are examined in the review. Analysis of the ability of liposomes to render biological effect depending on their composition, preparation method and administration route is carried out. These data should be taken into consideration during creation of liposome drugs and vaccines.
authors.forename: V I
authors.initials: VI
authors.lastname: Efremenko
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects / Q000276:immunology; D016503:Drug Delivery Systems / Q000009:adverse effects*; D006801:Humans; D008081:Liposomes / Q000009:adverse effects* / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use; D049329:Nanostructures / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D008081:Liposomes