title: A novel role for the cell cycle regulatory complex cyclin D1-CDK4 in gluconeogenesis.
abstract: Dysregulation of gluconeogenesis is a key pathological feature of type 2 diabetes. However, the molecular mechanisms underlying the regulation of gluconeogenesis remain unclear. Bhalla et al. recently reported that cyclin D1 suppresses hepatic gluconeogenesis through CDK4-dependent phosphorylation of PGC1alpha and consequent inhibition of its activity. The cyclin D1-CDK4 might thus serve as an important link between the cell cycle and control of energy metabolism through modulation of PGC1alpha activity.
authors.affiliation: Division of Diabetes and Endocrinology Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hosooka
authors.affiliation: Division of Diabetes and Endocrinology Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Ogawa
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D019938:Cyclin D1 / Q000502:physiology*; D051358:Cyclin-Dependent Kinase 4 / Q000502:physiology*; D005943:Gluconeogenesis / Q000502:physiology*; D006801:Humans
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4
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