title: Paediatric Crohn Disease: Disease Activity and Growth in the BELCRO Cohort After 3 Years Follow-up.
abstract: The Belgian registry for paediatric Crohn disease (BELCRO) cohort is a prospective, multicentre registry for newly diagnosed paediatric patients with Crohn disease (CD) (<18 years) recruited from 2008 to 2010 to identify predictive factors for disease activity and growth.
  
  
  
  Data from the BELCRO database were evaluated at diagnosis, 24 and 36 months follow-up.
  
  
  
  At month 36 (M36), data were available on 84 of the 98 patients included at diagnosis. Disease activity evolved as follows: inactive 5% to 70%, mild 19% to 24%, and moderate to severe 76% to 6%. None of the variables such as age, sex, diagnostic delay, type of treatment, disease location, disease activity at diagnosis, and growth were associated with disease activity at M36. Paediatricians studied significantly less patients with active disease at M36 compared with adult physicians. Sixty percent of the patients had biologicals as part of their treatment at M36. Adult gastroenterologists initiated biologicals significantly earlier. They were the only factor determining biologicals' initiation, not disease location or disease severity at diagnosis. Median body mass index (BMI) z score evolved from -0.97 (range -5.5-2.1) to 0.11 (range -3.4-2) and median height z score from -0.15 (range -3.4-1.6) to 0.12 (range -2.3-2.3) at M36. None of the variables mentioned above influenced growth over time.
  
  
  
  Present treatment strategies lead to good disease control in the BELCRO cohort after 3 years. Logistic regression analysis did not show any influence of disease location or present treatment strategy on disease activity and growth, but patients under paediatric care had significantly less severe disease at M36.
authors.affiliation: *Paediatric Gastroenterology, UZ Brussel †Free university Brussels (VUB), Brussel ‡Paediatric Gastroenterology, UZ Gasthuisberg, Leuven §Paediatric Gastroenterology, UCL St Luc, Brussel ||Paediatric Gastroenterology, UZ Gent, Gent ¶Pediatric Gastroenterology, HUDERF, Brussel #Pediatric Gastroenterology, CHC Espérance, Liège **Paediatric Gastroenterology, Jessa Hospital, Hasselt ††Paediatric Gastroenterology, ZOL, Genk ‡‡Gastroenterology, UCL St Luc, Brussel §§Gastroenterology, UZ Gent, Gent ||||Gastroenterology,H Hart Hospital, Roeselare ¶¶Gastroenterology, Imelda Hospital, Bonheiden ##Gastroenterology, UCL Mont Godinne, Mont Godinne ***Gastroenterology, ULB Erasme, Brussel †††Gastroenterology, UZ Gasthuisberg, Leuven ‡‡‡Gastroenterology, CHU St Joseph §§§Gastroenterology, CHU and University of Liège, Liège ||||||Gastroenterology, Clinique St Pierre, Ottignies, Belgium.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: De Greef
authors.forename: Ilse
authors.initials: I
authors.lastname: Hoffman
authors.forename: Francoise
authors.initials: F
authors.lastname: Smets
authors.forename: Stephanie
authors.initials: S
authors.lastname: Van Biervliet
authors.forename: Patrick
authors.initials: P
authors.lastname: Bontems
authors.forename: Bruno
authors.initials: B
authors.lastname: Hauser
authors.forename: Isabelle
authors.initials: I
authors.lastname: Paquot
authors.forename: Philippe
authors.initials: P
authors.lastname: Alliet
authors.forename: Wim
authors.initials: W
authors.lastname: Arts
authors.forename: Olivier
authors.initials: O
authors.lastname: Dewit
authors.forename: Martine
authors.initials: M
authors.lastname: De Vos
authors.forename: Filip
authors.initials: F
authors.lastname: Baert
authors.forename: Peter
authors.initials: P
authors.lastname: Bossuyt
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Rahier
authors.forename: Denis
authors.initials: D
authors.lastname: Franchimont
authors.forename: Severine
authors.initials: S
authors.lastname: Vermeire
authors.forename: Fernand
authors.initials: F
authors.lastname: Fontaine
authors.forename: Edouard
authors.initials: E
authors.lastname: Louis
authors.forename: J C
authors.initials: JC
authors.lastname: Coche
authors.forename: Gigi
authors.initials: G
authors.lastname: Veereman
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001530:Belgium; D001827:Body Height; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003082:Colectomy; D003131:Combined Modality Therapy; D003424:Crohn Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D016208:Databases, Factual; D018450:Disease Progression; D004322:Drainage; D004750:Enteral Nutrition; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy; D007082:Ileum / Q000601:surgery; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents