title: One ring to rule them all: Current trends in combating bacterial resistance to the β-lactams.
abstract: From humble beginnings of a contaminated petri dish, β-lactam antibiotics have distinguished themselves among some of the most powerful drugs in human history. The devastating effects of antibiotic resistance have nevertheless led to an "arms race" with disquieting prospects. The emergence of multidrug resistant bacteria threatens an ever-dwindling antibiotic arsenal, calling for new discovery, rediscovery, and innovation in β-lactam research. Here the current state of β-lactam antibiotics from a structural perspective was reviewed.
authors.affiliation: Department of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3.
authors.forename: Dustin T
authors.initials: DT
authors.lastname: King
authors.affiliation: Department of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3.
authors.forename: Solmaz
authors.initials: S
authors.lastname: Sobhanifar
authors.affiliation: Department of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3.
authors.forename: Natalie C J
authors.initials: NC
authors.lastname: Strynadka
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship; D018440:beta-Lactam Resistance / Q000187:drug effects; D065093:beta-Lactamase Inhibitors / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors
keywords: multidrug resistant bacteria; penicillin-binding protein; resistance; β-lactam; β-lactamase
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