title: Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione.
abstract: New 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione have been synthesized by the reaction of 3-cyclohexyl-7-thio-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione with alkylhalogenides. The synthesized compounds were tested for antioxidant activity on the model of Fe(2+)-dependent oxidation of adrenaline in vitro. It was found that the antiradical activity of 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione significantly depends on the structure of the substituent which is part of the thioether fragment of the base molecule.
authors.affiliation: A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova str. 28, 119991, Moscow, Russian Federation.
authors.forename: Yuriy M
authors.initials: YM
authors.lastname: Kononevich
authors.affiliation: Institute of Pharmacology and Toxicology, National Academy of Medical Science of Ukraine, Ezhena Pot'je str. 14, 03680, Kyiv, Ukraine.
authors.forename: Ludmila S
authors.initials: LS
authors.lastname: Bobkova
authors.affiliation: T. G. Shevchenko Chernihiv National Pedagogical University, Het'mana Polubotka str. 53, 14013, Chernihiv, Ukraine.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Smolski
authors.affiliation: Institute of Pharmacology and Toxicology, National Academy of Medical Science of Ukraine, Ezhena Pot'je str. 14, 03680, Kyiv, Ukraine.
authors.forename: Anatoly M
authors.initials: AM
authors.lastname: Demchenko
keywords: 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione; Alkylation; Antioxidant activity; Fe2+-dependent oxidation of adrenaline
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