title: Efficacy of the Bunium persicum (Boiss) Essential Oil against Acute Toxoplasmosis in Mice Model.
abstract: BACKGROUND
  We evaluated the in vivo activity of Bunium persicum (Boiss) essential oil on infected mice with acute toxoplasmosis.
  
  
  METHODS
  To evaluate prophylactic effects, male NMRI mice received B. persicum essential oil at the concentrations of 0.05 and 0.1 mL/kg for 14 days. After 24 h mice were infected intraperitonealy with 1×10(4) tachyzoites of T. gondii, RH strain. In order to investigate therapeutic effects, mice were infected and then received B. persicum oil at the concentrations of 0.05 and 0.1 ml/kg two times a day for 5 days. The time/mean time of death in all infected mice and the number of tachyzoites from infected mice were recorded.
  
  
  RESULTS
  The time/mean time of death of infected mice was 8 and 9 days after oral administration of B. persicum oil at the concentration of 0.05 and 0.1 mL/kg, respectively (P<0.05). In contrast, the time/mean time of death control group was 5 days. In addition, B. persicum significantly reduced the mean number of tachyzoites compared with control group. The time/mean time of death of infected mice was 6 and 7 days after oral administration of B. persicum essential oil at the concentration of 0.05 and 0.1 mL/kg, respectively. In contrast, the time/mean time of death control group was 5 days. B. persicum especially at the concentration of 0.1 ml/kg significantly reduced the mean number of tachyzoites compared with control group.
  
  
  CONCLUSIONS
  The results showed the potential of B. persicum essential oil as a natural source for the production of new prophylactic agent for use in toxoplasmosis.
authors.affiliation: Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Tavakoli Kareshk
authors.affiliation: Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Keyhani
authors.affiliation: Research Center for Tropical and Infectious Diseases, Kerman University of Medical Science, Kerman, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Mahmoudvand
authors.affiliation: Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Razieh
authors.initials: R
authors.lastname: Tavakoli Oliaei
authors.affiliation: Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Asadi
authors.affiliation: Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Moazameh
authors.initials: M
authors.lastname: Andishmand
authors.affiliation: Department of Physiology, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Azzizian
authors.affiliation: Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Babaei
authors.affiliation: Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Naser
authors.initials: N
authors.lastname: Zia-Ali
keywords: Bunium persicum Boiss; Prophylactic; Therapeutic; Toxoplasma gondii
references.citation: J Ethnopharmacol. 2012 Mar 27;140(2):447-51
references.pmid: 22301447
references.citation: Exp Parasitol. 2014 Jan;136:20-6
references.pmid: 24184772
references.citation: J Agric Food Chem. 2007 Jul 25;55(15):6300-8
references.pmid: 17602646
references.citation: Pharm Biol. 2011 Feb;49(2):146-51
references.pmid: 20942602
references.citation: J Chem Ecol. 2007 Nov;33(11):2123-32
references.pmid: 17932718
references.citation: Korean J Parasitol. 2014 Dec;52(6):653-9
references.pmid: 25548417
references.citation: Trends Parasitol. 2006 Mar;22(3):137-42
references.pmid: 16446116
references.citation: Acta Trop. 2013 Oct;128(1):110-5
references.pmid: 23850505
references.citation: Antimicrob Agents Chemother. 1984 May;25(5):571-4
references.pmid: 6732225
references.citation: Iran J Parasitol. 2013 Jul;8(3):367-75
references.pmid: 24454428
references.citation: Curr HIV Res. 2007 Mar;5(2):273-4
references.pmid: 17346141
references.citation: Parasite Immunol. 2015 Jul;37(7):362-7
references.pmid: 25891186
references.citation: Microbiol Rev. 1995 Jun;59(2):201-22
references.pmid: 7603409
references.citation: Phytomedicine. 2005 Jun;12(6-7):514-35
references.pmid: 16008131
references.citation: J Nat Prod. 1991 Jul-Aug;54(4):1102-4
references.pmid: 1791475
references.citation: Clin Microbiol Infect. 2002 Oct;8(10):634-40
references.pmid: 12390281
references.citation: Molecules. 2012 Apr 26;17 (5):4836-50
references.pmid: 22538487