title: Clinical implications of β-catenin protein expression in breast cancer.
abstract: The objective of this study was to examine the expression and significance of β-catenin in the diagnosis and prognosis of breast cancer. Overall, 241 patients with histologically confirmed breast cancer who had undergone radical surgery were enrolled in this study. β-catenin protein expression in breast cancer samples was evaluated by immunohistochemistry. β-catenin was expressed in Nuclei/Plasma of the samples from 41 patients. β-catenin protein expression correlated with the histological grade of the tumor (P<0.05) and Ki-67 labeling (P<0.01). Survival analysis showed that β-catenin expression negatively correlated with breast cancer-specific survival. Our results showed prominent expression of β-catenin in breast cancer and strongly implicate the β-catenin in tumor promotion.
authors.affiliation: Department of Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University Dalian 116027, Liaoning Province, China.
authors.forename: Ziyi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University Dalian 116027, Liaoning Province, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University Dalian 116027, Liaoning Province, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University Dalian 116027, Liaoning Province, China.
authors.forename: Jianing
authors.initials: J
authors.lastname: Niu
authors.affiliation: Department of Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University Dalian 116027, Liaoning Province, China.
authors.forename: Zhenhai
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University Dalian 116027, Liaoning Province, China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University Dalian 116027, Liaoning Province, China.
authors.forename: Caigang
authors.initials: C
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D051176:beta Catenin / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D051176:beta Catenin
keywords: Breast cancer; Ki-67; survival; tumor marker; β-catenin
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