title: Absorbable magnesium-based stent: physiological factors to consider for in vitro degradation assessments.
abstract: Absorbable metals have been widely tested in various in vitro settings using cells to evaluate their possible suitability as an implant material. However, there exists a gap between in vivo and in vitro test results for absorbable materials. A lot of traditional in vitro assessments for permanent materials are no longer applicable to absorbable metallic implants. A key step is to identify and test the relevant microenvironment and parameters in test systems, which should be adapted according to the specific application. New test methods are necessary to reduce the difference between in vivo and in vitro test results and provide more accurate information to better understand absorbable metallic implants. In this investigative review, we strive to summarize the latest test methods for characterizing absorbable magnesium-based stent for bioabsorption/biodegradation behavior in the mimicking vascular environments. Also, this article comprehensively discusses the direction of test standardization for absorbable stents to paint a more accurate picture of the in vivo condition around implants to determine the most important parameters and their dynamic interactions.
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China and National Science Foundation Engineering Research Center for Revolutionizing Metallic Biomaterials, North Carolina A & T State University, Greensboro, NC 27411, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China and National Science Foundation Engineering Research Center for Revolutionizing Metallic Biomaterials, North Carolina A & T State University, Greensboro, NC 27411, USA.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Smith
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China and National Science Foundation Engineering Research Center for Revolutionizing Metallic Biomaterials, North Carolina A & T State University, Greensboro, NC 27411, USA.
authors.forename: Jagannathan
authors.initials: J
authors.lastname: Sankar
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China and National Science Foundation Engineering Research Center for Revolutionizing Metallic Biomaterials, North Carolina A & T State University, Greensboro, NC 27411, USA.
authors.forename: Yeoheung
authors.initials: Y
authors.lastname: Yun
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China and National Science Foundation Engineering Research Center for Revolutionizing Metallic Biomaterials, North Carolina A & T State University, Greensboro, NC 27411, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Huang
keywords: absorbable stent; biodegradation; in vitro; in vivo; magnesium
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