title: Visible-Light-Mediated Synthesis of Amides from Aldehydes and Amines via in Situ Acid Chloride Formation.
abstract: An efficient visible-light photocatalysis-based one-pot amide synthesis method was developed; visible-light irradiation of a mixture of an aldehyde, tert-butyl hydrogen peroxide, and N-chlorosuccinimide using a Ru(bpy)3Cl2 photocatalyst afforded an acid chloride, which subsequently reacted with amine to yield the corresponding amide. The reaction was used to synthesize moclobemide and a D3 receptor intermediate.
authors.affiliation: Department of Chemistry and Applied Chemistry, Hanyang University , Ansan 426-791, Republic of Korea.
authors.forename: Naeem
authors.initials: N
authors.lastname: Iqbal
authors.affiliation: Department of Chemistry, Chung-Ang University , Seoul 156-756, Republic of Korea.
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Cho