title: Discovering potential drug-targets for personalized treatment of autoimmune disorders - what we learn from epidermolysis bullosa acquisita.
abstract: BACKGROUND
  Epidermolysis bullosa acquisita (EBA) is a chronic autoimmune bullous dermatosis (AIBD). Treatment of EBA is challenging and mostly relies on systemic immunosuppression. During the last decade, intensive research led to the identification of new potential therapeutic targets that interfere in different phases of disease progression. Therapeutic interventions acting upon these candidate drug targets in animal models of EBA, such as cytokine-modulating biologics and small molecules, have validated them as potential new therapeutic strategies for EBA patients.
  
  
  METHODS
  In this paper, we review the current treatments for EBA, describe the pathogenesis of the disease, and finally specify new drug candidates for the development of a more specific therapy with minimized side-effects for EBA and potentially other autoimmune diseases.
  
  
  CONCLUSIONS
  We currently understand EBA as a disease that evolves from the interplay of many different signaling pathways. These signaling pathways, which are described in this review, provide new targets for EBA treatment. The ultimate goal of this research field is the development of specific, pathogenesis-based therapeutic strategies. Through identification of up- or downregulated pathways that dominate disease progression in individual patients, we expect therapy in EBA to become more and more precise and move towards a patient-based therapy.
authors.affiliation: a Lübeck Institute of Experimental Dermatology (LIED) , University of Lübeck , Lübeck , Germany.
authors.forename: Mareike
authors.initials: M
authors.lastname: Witte
authors.affiliation: a Lübeck Institute of Experimental Dermatology (LIED) , University of Lübeck , Lübeck , Germany.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koga
authors.affiliation: b Institute of Cutaneous Cell Biology , Kurume University , Kurume , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.affiliation: a Lübeck Institute of Experimental Dermatology (LIED) , University of Lübeck , Lübeck , Germany.
authors.forename: Ralf J
authors.initials: RJ
authors.lastname: Ludwig
authors.affiliation: a Lübeck Institute of Experimental Dermatology (LIED) , University of Lübeck , Lübeck , Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Bieber
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D004195:Disease Models, Animal; D018450:Disease Progression; D015195:Drug Design; D016107:Epidermolysis Bullosa Acquisita / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D058990:Molecular Targeted Therapy; D057285:Precision Medicine; D015398:Signal Transduction / Q000276:immunology
keywords: Drug targets; Epidermolysis bullosa acquisita; autoimmune bullous disease; pathogenesis; signaling