title: Possible serotonin syndrome with carbidopa-levodopa and linezolid.
abstract: OBJECTIVE
  Serotonin syndrome (SS) can occur when linezolid is combined with other serotonergic agents.
  
  
  METHODS
  We report a case of possible SS in an elderly patient receiving linezolid in combination with carbidopa-levodopa (CL).
  
  
  CONCLUSIONS
  Although certain classes of agents are commonly reported as causing SS among patients receiving linezolid, there are no specific case reports detailing this reaction with CL. Linezolid combined with CL should generally be avoided; however, if linezolid must be used, discontinuation of other agents with serotonergic activity is recommended with careful monitoring for signs and symptoms of SS.
authors.affiliation: Department of Pharmacy, University of Chicago Medicine, Chicago, IL, USA.
authors.forename: N N
authors.identifier: http://orcid.org/0000-0002-8937-8039
authors.initials: NN
authors.lastname: Pettit
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: V
authors.initials: V
authors.lastname: Alonso
authors.affiliation: Creighton University School of Medicine, Omaha, NE, USA.
authors.forename: E
authors.initials: E
authors.lastname: Wojcik
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: E C
authors.initials: EC
authors.lastname: Anyanwu
authors.affiliation: Department of Medicine, Section of Infectious Diseases and Global Health, University of Chicago, Chicago, IL, USA.
authors.forename: L
authors.initials: L
authors.lastname: Ebara
authors.affiliation: Department of Medicine, Section of Infectious Diseases and Global Health, University of Chicago, Chicago, IL, USA.
authors.forename: J-L
authors.initials: JL
authors.lastname: Benoit
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D002230:Carbidopa / Q000008:administration & dosage / Q000009:adverse effects*; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects*; D000069349:Linezolid / Q000008:administration & dosage / Q000009:adverse effects*; D018490:Serotonin Agents / Q000008:administration & dosage / Q000009:adverse effects; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents; D018491:Dopamine Agonists; D004338:Drug Combinations; D018490:Serotonin Agents; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D000069349:Linezolid; D002230:Carbidopa
keywords: carbidopa-levodopa; linezolid; serotonin syndrome