title: [Renal hypophosphatemia:pathophysiology and treatment].
abstract: Serum level of phosphate is regulated by the kidney, especially proximal tubule. The transcellular transport of phosphate in the proximal tubule is mediated via Na dependent transporters, i.e., NPT2a and NPT2b at the luminal membrane, and unknown channel at the basolateral side. The transport of phosphate via NPT2a and NPT2b is further regulated by factors, such as PTH, FGF23, and 1,25(OH)(2)D. Several hereditary diseases that cause hypophoshatemia specically are known. In addition, dysfunction of proximal tubule may develop Fanconi syndrome, which also causes hypherphosphaturia. In this section, I describe the renal mechanisms of phosphate handling and the causes of hypophosphatemia along with its treatment.
authors.affiliation: Department of Pediatrics, Toho University Ohashi Hospital, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sekine
mesh_terms: D000284:Administration, Oral; D002117:Calcitriol / Q000502:physiology; D018118:Chloride Channels; D057973:Dent Disease / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D005198:Fanconi Syndrome / Q000209:etiology / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D006801:Humans; D017674:Hypophosphatemia / Q000209:etiology* / Q000378:metabolism* / Q000628:therapy; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D028361:Mitochondrial Diseases; D009800:Oculocerebrorenal Syndrome; D010281:Parathyroid Hormone / Q000502:physiology; D010710:Phosphates / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases; D017553:Phosphorus Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D050613:Sodium-Phosphate Cotransporter Proteins, Type IIa / Q000502:physiology; D050615:Sodium-Phosphate Cotransporter Proteins, Type IIc / Q000502:physiology; D014807:Vitamin D / Q000008:administration & dosage
chemical_list: C097503:CLC-5 chloride channel; D018118:Chloride Channels; C000717427:FGF23 protein, human; D010281:Parathyroid Hormone; D010710:Phosphates; D017553:Phosphorus Compounds; C493554:SLC34A1 protein, human; C493562:SLC34A3 protein, human; D050613:Sodium-Phosphate Cotransporter Proteins, Type IIa; D050615:Sodium-Phosphate Cotransporter Proteins, Type IIc; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D010744:Phosphoric Monoester Hydrolases; C075695:OCRL protein, human; D002117:Calcitriol