title: Fluorescent nanogel based on four-arm PEG-PCL copolymer with porphyrin core for bioimaging.
abstract: Four-arm PEG-PCL copolymer with porphyrin core (POR-PEG-PCL) exhibits beneficial fluorescence ability in vivo. To further develop an application of thermosensitive porphyrin hydrogel based on four-arm PEG-PCL copolymer as a drug carrier, a POR-PEG-PCL nanogel was tracked and located to tumor tissue with porphyrin as a fluorescence tag via intravenous injection. The structure and function of the nanogel were evaluated by TEM, DLS, H-NMR, UV-vis and fluorescence spectra. The fluorescent nanogel was monitored by an in vivo imaging system with hepatoma tumor-bearing mice. Good biocompatibility and safety in vitro and in vivo show that the POR-PEG-PCL nanogel is a potential drug carrier that targets tumor tissues with fluorescence bioimaging.
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.
authors.forename: Xia
authors.initials: X
authors.lastname: Dong
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.
authors.forename: Chang
authors.initials: C
authors.lastname: Wei
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Lu
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.
authors.forename: Tianjun
authors.initials: T
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China. Electronic address: lvfeng2002@163.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Lv
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D056945:Hep G2 Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D061848:Optical Imaging; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D011091:Polyesters; D011166:Porphyrins; C502908:poly(ethylene glycol)-poly(caprolactone)-poly(ethylene glycol); D011092:Polyethylene Glycols
keywords: Fluorescence imaging; Hepatoma tumor; Porphyrin; Thermosensitive nanogels