title: TAVI or No TAVI: identifying patients unlikely to benefit from transcatheter aortic valve implantation.
abstract: Transcatheter aortic valve implantation (TAVI) has spawned the evolution of novel catheter-based therapies for a variety of cardiovascular conditions. Newer device iterations are delivering lower peri- and early post-procedural complication rates in patients with aortic stenosis, who were otherwise deemed too high risk for conventional surgical valve replacement. Yet beyond the post-procedural period, a considerable portion of current TAVI recipients fail to derive a benefit from TAVI, either dying or displaying a lack of clinical and functional improvement. Considerable interest now lies in better identifying factors likely to predict futility post-TAVI. Implicit in this are the critical roles of frailty, disability, and a multimorbidity patient assessment. In this review, we outline the roles that a variety of medical comorbidities play in determining futile post-TAVI outcomes, including the critical role of frailty underlying the identification of patients unlikely to benefit from TAVI. We discuss various TAVI risk scores, and further propose that by combining such scores along with frailty parameters and the presence of specific organ failure, a more accurate and holistic assessment of potential TAVI-related futility could be achieved.
authors.affiliation: Québec Heart and Lung Institute, Laval University, 2725 chemin Ste-Foy, Québec City, QC, Canada Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia Cleveland Clinic Coordinating Center for Clinical Research (C5R), Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Rishi
authors.initials: R
authors.lastname: Puri
authors.affiliation: Cardiology Department, AP-HP, Hôpital Bichat Claude Bernard, Paris, France University Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Iung
authors.affiliation: Saint Luke's Mid America Heart Institute, Kansas City, MO, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Cohen
authors.affiliation: Québec Heart and Lung Institute, Laval University, 2725 chemin Ste-Foy, Québec City, QC, Canada josep.rodes@criucpq.ulaval.ca.
authors.forename: Josep
authors.initials: J
authors.lastname: Rodés-Cabau
mesh_terms: D001021:Aortic Valve; D001024:Aortic Valve Stenosis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D012307:Risk Factors; D065467:Transcatheter Aortic Valve Replacement; D016896:Treatment Outcome
keywords: Aortic stenosis; Futility; Risk scores; Transcatheter aortic valve implantation