title: HIV Susceptibility of human antigen-specific CD4 T cells in AIDS pathogenesis and vaccine response.
abstract: HIV causes infection and progressive depletion of human CD4 T cells. Emerging data have shown that antigen-specific CD4 T-cell subsets manifest differential susceptibility to HIV, potentially leading to pathogen-specific immune failure and opportunistic infections. This concept was recently explored in context of vectors utilized in HIV vaccine trials, and the data suggest that adenovirus type 5(Ad5)-specific CD4 T cells elicited by Ad5-HIV vaccine may be particularly susceptible to HIV, potentially rendering Ad5 vaccine recipients susceptible to HIV acquisition. We here examined recent data regarding the HIV susceptibility of antigen-specific CD4 T cells induced during infection or HIV vaccination and discussed its potential impact on HIV acquisition risk posed by HIV vaccination.
authors.affiliation: a Department of Microbiology & Immunology and Sealy Center for Vaccine Development , University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Haitao
authors.initials: H
authors.lastname: Hu
authors.affiliation: a Department of Microbiology & Immunology and Sealy Center for Vaccine Development , University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Fengliang
authors.initials: F
authors.lastname: Liu
authors.affiliation: b International Vaccine Institute , Seoul , Republic of Korea.
authors.forename: Jerome
authors.initials: J
authors.lastname: Kim
authors.affiliation: c U.S. Military HIV Research Program, Henry M. Jackson Foundation , Walter Reed Army Institute of Research , Silver Spring , MD , USA.
authors.forename: Silvia
authors.initials: S
authors.lastname: Ratto-Kim
mesh_terms: D016915:AIDS Vaccines / Q000009:adverse effects* / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology*; D004198:Disease Susceptibility; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control*; D006801:Humans
chemical_list: D016915:AIDS Vaccines
keywords: CD4 T cells; HIV susceptibility; HIV vaccine; antigen specificity; pathogenesis
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