title: Predictive macrosomia birthweight thresholds for adverse maternal and neonatal outcomes.
abstract: OBJECTIVE
  We examined the predictive macrosomia birthweight thresholds for adverse maternal and neonatal outcomes.
  
  
  METHODS
  This was a multicenter, retrospective cohort study conducted in China. We selected 178 709 singletons weighing ≥2500 g with gestational age 37-44 weeks. We categorized macrosomia with two gradations (4000-4499 g and ≥4500 g) and compared them with a normosomic reference group of infants with birthweight 2500-3999 g.
  
  
  RESULTS
  The risks of obstetric and neonatal complications increased when infants had a birthweight of ≥4000 g. The rates of infant mortality, Apgar score ≤3 at 5 min, respiratory and neurological disorders rose significantly among neonates weighing ≥4500 g.
  
  
  CONCLUSIONS
  A definition of macrosomia as birthweight ≥4000 g could be beneficial as an indicator of obstetric and newborn complications, and birthweight ≥4500 g might be predictive of severe infant morbidity and mortality risk.
authors.affiliation: a Department of Neonatology , Children's Hospital of Fudan University , Shanghai , P.R. China .
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: a Department of Neonatology , Children's Hospital of Fudan University , Shanghai , P.R. China .
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.affiliation: a Department of Neonatology , Children's Hospital of Fudan University , Shanghai , P.R. China .
authors.forename: Shulian
authors.initials: S
authors.lastname: Zhang
authors.affiliation: b Zhejiang Jiaxing the First Hospital , Jiaxing , P.R. China .
authors.forename: Xueqin
authors.initials: X
authors.lastname: Wu
authors.affiliation: c Shanghai Jiading Maternal and Child Care Hospital , Shanghai , P.R. China .
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.affiliation: d Ningbo Women and Children's Hospital , Ningbo , P.R. China .
authors.forename: Qin
authors.initials: Q
authors.lastname: Lv
authors.affiliation: d Ningbo Women and Children's Hospital , Ningbo , P.R. China .
authors.forename: Dongmei
authors.initials: D
authors.lastname: Gan
authors.affiliation: e Guizhou Maternal and Child Care Hospital , Guizhou , P.R. China .
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.affiliation: f Qilu Hospital of Shangdong University , Shangdong , P.R. China .
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: g Jiangsu Wuxi Maternal and Child Health Care Hospital , Wuxi , P.R. China .
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: h Xinjiang Yili Maternal and Child Care Hospital , Yili , P.R. China .
authors.forename: Jiarong
authors.initials: J
authors.lastname: Lu
authors.affiliation: i The Third Hospital of Baotou Steel Group , Baotou , P.R. China .
authors.forename: Haiying
authors.initials: H
authors.lastname: He
authors.affiliation: j Obstetrics and Gynecology Hospital of Fudan University , Shanghai , P.R. China .
authors.forename: Jimei
authors.initials: J
authors.lastname: Wang
authors.affiliation: k Xinjiang Boertala Hospital , Boertala , P.R. China , and.
authors.forename: Hua
authors.initials: H
authors.lastname: Xin
authors.affiliation: l Shanxi Maternal and Child Care Hospital , Shanxi , P.R. China.
authors.forename: Zhankui
authors.initials: Z
authors.lastname: Li
authors.affiliation: a Department of Neonatology , Children's Hospital of Fudan University , Shanghai , P.R. China .
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D000328:Adult; D001034:Apgar Score; D001724:Birth Weight; D016022:Case-Control Studies; D002681:China; D036861:Delivery, Obstetric / Q000379:methods; D005260:Female; D005320:Fetal Macrosomia / Q000150:complications* / Q000401:mortality; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology* / Q000401:mortality; D016015:Logistic Models; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D012306:Risk
keywords: Birthweight; macrosomia; outcome; threshold