title: [Evaluate the early changes of renal ischemia-reperfusion by susceptibility weighted imaging:primary experiment study].
abstract: OBJECTIVE
  To explore whether susceptibility weighted imaging (SWI) could diagnose the early changes of renal IRI in vivo by modeling the renal ischemia-reperfusion (IRI) of rabbit.
  
  
  METHODS
  Thrity four New Zealand white rabbits were chosen, the vesseles of the left kidney of rabbits were ligated for 60 minutes, then the renal ischemia-reperfusion model was established. Respectively, the rabbits before ligation, 0.5, 24 and 48 h after the ligation, were examined with MR, then the signal of the cortex and medulla was analyzed in SWI and T2WI, the imaging features were compared with histopathology.
  
  
  RESULTS
  The inner medullary of renal showed high signal, low signal in the outer medulla and mildly high in the cortex before ligation in T2WI sequence, which showed the typical three-band signal distribution, while the outer medulla showed wildly hypo-signal in SWI, the remnants showed high signal; kidney swelled significantly 0.5 hour after ligation, the stripe of cortex became thin, however, the inner medulla and outer medulla widened. The hypo-signal of the outer medulla faded, while the signal of inner medullary and cortical slightly elevated. The signal intensity of outer medulla lowered more obviously in SWI, the margin of the cortex and medulla became more clearly 24 and 48 h after ligation,However the signal of the outer medulla was higher than normal kidney in the SWI, and punctuate or stripe haemorrhage occurred in the outer medulla. Respectively, the number of punctuate, stripe haemorrhage detected by SWI in the out medulla of kidney 0.5, 24 and 48 h after ligation were 0, 2.50, 6.75 (F=52.17, P<0.01), Meanwhile, the number detected by T2WI was 0, 1.13, 2.88 (F=15.65, P<0.01); the number of hemorrhage which was detected by SWI and T2WI in the outer medulla among different timepoint have the statistical significance (t=4.83, P<0.01).
  
  
  CONCLUSIONS
  SWI can clearly show early changes in IRI-renal, especially in the outer medulla of the renal, the technique was helpful to assess the early changes of renal IRI.
authors.affiliation: Department of Radiology, First People's Hospital of Changzhou, Changzhou 213003, China.
authors.forename: Jinggang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, First People's Hospital of Changzhou, Changzhou 213003, China; Email: suzhxingwei@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Xing
authors.affiliation: Department of Radiology, First People's Hospital of Changzhou, Changzhou 213003, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Radiology, First People's Hospital of Changzhou, Changzhou 213003, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Pan
authors.affiliation: Department of Radiology, First People's Hospital of Changzhou, Changzhou 213003, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Radiology, First People's Hospital of Changzhou, Changzhou 213003, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zha
authors.affiliation: Department of Radiology, First People's Hospital of Changzhou, Changzhou 213003, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Radiology, First People's Hospital of Changzhou, Changzhou 213003, China.
authors.forename: Shijun
authors.initials: S
authors.lastname: Xing
mesh_terms: D000818:Animals; D004198:Disease Susceptibility; D007511:Ischemia; D007668:Kidney; D007674:Kidney Diseases; D008026:Ligation; D011817:Rabbits; D015424:Reperfusion; D015427:Reperfusion Injury