title: Adsorption of the cis-[Pt(NH3)2(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals as a smart way to selectively release activated cis-[Pt(NH3)2Cl2] (cisplatin) in tumor tissues.
abstract: The relevant adsorption of cis-[Pt(NH3)2(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals (nHAP) was observed and studied in water suspension. Phosphaplatin cytotoxicity, which is very low for HeLa, MCF-7 and HS-5 cell lines could be enhanced, reaching that of cisplatin, by interaction with solid nHAP. This effect stems from nHAP ability to catalyze the phosphaplatin hydrolysis, producing the same hydrolytic species responsible for cisplatin antitumor activity.
authors.affiliation: University of Salento, Department of Biological and Environmental Sciences and Technologies, Via Monteroni, 73100 Lecce, Italy. Electronic address: michele.benedetti@unisalento.it.
authors.forename: Michele
authors.initials: M
authors.lastname: Benedetti
authors.affiliation: University of Salento, Department of Biological and Environmental Sciences and Technologies, Via Monteroni, 73100 Lecce, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: De Castro
authors.affiliation: Neuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Romano
authors.affiliation: University of Salento, Department of Biological and Environmental Sciences and Technologies, Via Monteroni, 73100 Lecce, Italy.
authors.forename: Danilo
authors.initials: D
authors.lastname: Migoni
authors.affiliation: University of Salento, Department of Biological and Environmental Sciences and Technologies, Via Monteroni, 73100 Lecce, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Piccinni
authors.affiliation: University of Salento, Department of Biological and Environmental Sciences and Technologies, Via Monteroni, 73100 Lecce, Italy.
authors.forename: Tiziano
authors.initials: T
authors.lastname: Verri
authors.affiliation: Bioecoactive s.r.l., Via San Donato, 5 - 40057 Granarolo Dell'Emilia, Bologna, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Lelli
authors.affiliation: Bioecoactive s.r.l., Via San Donato, 5 - 40057 Granarolo Dell'Emilia, Bologna, Italy.
authors.forename: Norberto
authors.initials: N
authors.lastname: Roveri
authors.affiliation: University of Salento, Department of Biological and Environmental Sciences and Technologies, Via Monteroni, 73100 Lecce, Italy. Electronic address: fp.fanizzi@unisalento.it.
authors.forename: Francesco P
authors.initials: FP
authors.lastname: Fanizzi
mesh_terms: D000327:Adsorption; D000970:Antineoplastic Agents / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles
chemical_list: D000970:Antineoplastic Agents; D017886:Durapatite; D002945:Cisplatin
keywords: Antitumor drug; Hydroxyapatite; Nanoparticles; Platinum drug; cisplatin; phosphaplatin