title: Autologous platelet lysate local injections for the treatment of refractory lateral epicondylitis.
abstract: BACKGROUND
  The purpose of this study was to investigate the efficacy and safety of autologous platelet lysate (APL) local injections in reducing pain and improving function in patients with refractory lateral epicondylitis.
  
  
  METHODS
  A total of 56 patients with refractory lateral epicondylitis were enrolled in this study. All the patients received three injections in one course of treatment. Subjective assessments include visual analog scale (VAS) pain score and Mayo elbow score before injection (baseline) and at 1, 6, and 12 months after injection.
  
  
  RESULTS
  Significant differences were observed in VAS and Mayo scores at baseline and at 1, 6, and 12 months after injection. Overall, the injections of APL improved local symptoms and all the patients recovered to normal elbow function with 12 months follow-up.
  
  
  CONCLUSIONS
  Local injections of APL resulted in favorable clinical outcomes for the treatment of lateral epicondylitis. APL could be clinically effective in the treatment of lateral epicondylitis.
authors.affiliation: Department of Bone and Joint Surgery, Wendeng Orthopaedic Hospital of Shandong Province, Wendeng, Shandong, 264400, China.
authors.forename: Xun-xiang
authors.initials: XX
authors.lastname: Tan
authors.affiliation: Department of Bone and Joint Surgery, Wendeng Orthopaedic Hospital of Shandong Province, Wendeng, Shandong, 264400, China.
authors.forename: Hai-yang
authors.initials: HY
authors.lastname: Ju
authors.affiliation: Department of Bone and Joint Surgery, Wendeng Orthopaedic Hospital of Shandong Province, Wendeng, Shandong, 264400, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Bone and Joint Surgery, Wendeng Orthopaedic Hospital of Shandong Province, Wendeng, Shandong, 264400, China. boneman@163.com.
authors.forename: Hong-jiang
authors.initials: HJ
authors.lastname: Jiang
authors.affiliation: Department of Bone and Joint Surgery, Wendeng Orthopaedic Hospital of Shandong Province, Wendeng, Shandong, 264400, China.
authors.forename: Jin-ping
authors.initials: JP
authors.lastname: Su
authors.affiliation: Department of Bone and Joint Surgery, Wendeng Orthopaedic Hospital of Shandong Province, Wendeng, Shandong, 264400, China.
authors.forename: Hua-jun
authors.initials: HJ
authors.lastname: Dong
authors.affiliation: Zhejiang Xingyue Biotechnology Co., Ltd, Hangzhou, 311121, China.
authors.forename: Ling-shuang
authors.initials: LS
authors.lastname: Wang
authors.affiliation: Department of Bone and Joint Surgery, Wendeng Orthopaedic Hospital of Shandong Province, Wendeng, Shandong, 264400, China.
authors.forename: De-bao
authors.initials: DB
authors.lastname: Zou
mesh_terms: D000328:Adult; D001792:Blood Platelets; D004551:Elbow Joint / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D018737:Hand Strength; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D016059:Range of Motion, Articular; D013716:Tennis Elbow / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*
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