title: A Wacky Bridge to mTORC1 Dimerization.
abstract: The activity of the mTORC1 protein complex depends on multiple metabolic inputs that regulate dimerization, recruitment to the lysosome, and activation. In this issue of Developmental Cell, David-Morrison et al. (2016) show that the Drosophila protein Wacky and its mammalian counterpart WAC act as adaptors in the process of mTORC1 dimerization.
authors.affiliation: Institut for Integrative Biology of the Cell (I2BC), CNRS, Université Paris-Sud, CEA, UMR 9198, 91190 Gif-sur-Yvette, France. Electronic address: jacques.montagne@i2bc.paris-saclay.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Montagne
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D029721:Drosophila Proteins; D058570:TOR Serine-Threonine Kinases; D004265:DNA Helicases