title: Computational power and generative capacity of genetic systems.
abstract: Semiotic characteristics of genetic sequences are based on the general principles of linguistics formulated by Ferdinand de Saussure, such as the arbitrariness of sign and the linear nature of the signifier. Besides these semiotic features that are attributable to the basic structure of the genetic code, the principle of generativity of genetic language is important for understanding biological transformations. The problem of generativity in genetic systems arises to a possibility of different interpretations of genetic texts, and corresponds to what Alexander von Humboldt called "the infinite use of finite means". These interpretations appear in the individual development as the spatiotemporal sequences of realizations of different textual meanings, as well as the emergence of hyper-textual statements about the text itself, which underlies the process of biological evolution. These interpretations are accomplished at the level of the readout of genetic texts by the structures defined by Efim Liberman as "the molecular computer of cell", which includes DNA, RNA and the corresponding enzymes operating with molecular addresses. The molecular computer performs physically manifested mathematical operations and possesses both reading and writing capacities. Generativity paradoxically resides in the biological computational system as a possibility to incorporate meta-statements about the system, and thus establishes the internal capacity for its evolution.
authors.affiliation: Department of Biology, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada. Electronic address: igamberdiev@mun.ca.
authors.forename: Abir U
authors.initials: AU
authors.lastname: Igamberdiev
authors.affiliation: National Research Center for Hematology, Moscow 125167, Russian Federation. Electronic address: nikitashk@gmail.com.
authors.forename: Nikita E
authors.initials: NE
authors.lastname: Shklovskiy-Kordi
mesh_terms: D019295:Computational Biology / Q000379:methods*; D039301:Computers, Molecular; D004247:DNA / Q000235:genetics*; D005815:Genetic Code / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D014176:Protein Biosynthesis; D012313:RNA / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D012313:RNA; D004247:DNA
keywords: Biological evolution; Generativity; Genetic code; Language; Molecular computation; Physical carriers of mathematical operations