title: Possible role of asymmetric dimethylarginine (ADMA) in prediction of perinatal outcome in preeclampsia and fetal growth retardation related to preeclampsia.
abstract: OBJECTIVE
  The objective of this study is to investigate maternal serum and neonatal umbilical cord asymmetric dimethylarginine (ADMA) levels in prediction of perinatal prognosis in pregnancies with preeclampsia (PE) and fetal intrauterine growth retardation (IUGR) accompanying PE (PE + IUGR).
  
  
  METHODS
  Maternal serum ADMA (msADMA) and neonatal umbilical cord ADMA (ucADMA) levels were studied from 34 patients with PE, 25 patients with PE + IUGR, and 30 healthy pregnant controls in this prospective case-control study. Umbilical artery Doppler indices of fetuses, birth weights, Apgar scores, umbilical artery pH measurements of neonates, and admissions to neonatal intensive care unit (NICU) were recorded.
  
  
  RESULTS
  Median msADMA was significantly higher in PE and PE + IUGR groups (p = 0.024 and p = 0.011, respectively), and ucADMA was significantly higher in PE and PE + IUGR groups than the control group (p = 0.029 and p = 0.018, respectively). Median msADMA and ucADMA levels were significantly higher in the PE + IUGR group than the PE group (p = 0.019 and 0.021, respectively). ucADMA levels did not correlate with fetal umbilical arterial blood flow neither in the PE nor in the PE + IUGR group (p = 0.518 and p = 0.892, respectively). None was related with neonatal umbilical artery pH or NICU admission rates.
  
  
  CONCLUSIONS
  msADMA and ucADMA correlated with severity of PE. msADMA and ucADMA failed to predict perinatal outcome in patients with PE and PE + IUGR.
authors.affiliation: a Department of Obstetrics and Gynecology , Uludag University School of Medicine , Bursa , Turkey.
authors.forename: Ertac
authors.initials: E
authors.lastname: Gumus
authors.affiliation: a Department of Obstetrics and Gynecology , Uludag University School of Medicine , Bursa , Turkey.
authors.forename: Mehmet Aral
authors.initials: MA
authors.lastname: Atalay
authors.affiliation: a Department of Obstetrics and Gynecology , Uludag University School of Medicine , Bursa , Turkey.
authors.forename: Bilge
authors.initials: B
authors.lastname: Cetinkaya Demir
authors.affiliation: a Department of Obstetrics and Gynecology , Uludag University School of Medicine , Bursa , Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Sahin Gunes
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D014469:Umbilical Arteries; D014470:Umbilical Cord / Q000098:blood supply*; D055815:Young Adult
chemical_list: C487735:dimethylarginine; D001120:Arginine
keywords: Asymmetric dimethylarginine; intrauterine growth retardation; perinatal care; preeclampsia