title: Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin.
abstract: C-di-AMP synthases are essential in several bacteria, including human pathogens; hence these enzymes are potential antibiotic targets. However, there is a dearth of small molecule inhibitors of c-di-AMP metabolism enzymes. Screening of 2000 known drugs against DisA has led to the identification of suramin, an antiparasitic drug as potent inhibitor of c-di-AMP synthase.
authors.affiliation: Graduate Program in Biochemistry, University of Maryland, College Park, Maryland 20742, USA and Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Clement
authors.initials: C
authors.lastname: Opoku-Temeng
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA and Center for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA. hsintim@purdue.edu.
authors.forename: Herman O
authors.initials: HO
authors.lastname: Sintim
mesh_terms: D000977:Antiparasitic Agents / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D019761:Phosphorus-Oxygen Lyases / Q000037:antagonists & inhibitors*; D013498:Suramin / Q000494:pharmacology*
chemical_list: D000977:Antiparasitic Agents; D004791:Enzyme Inhibitors; D013498:Suramin; D019761:Phosphorus-Oxygen Lyases