title: Evaluation of the radiological criteria to diagnose large vestibular aqueduct syndrome.
abstract: OBJECTIVE
  The main objective of the current work is to increase the sensitivity of the radiological diagnosis of the large vestibular aqueduct syndrome (LVAS). The specific aims were to compare between the two famous criteria to diagnose large vestibular aqueduct (LVA), (i.e., Valvassori and Cincinnati), to correlate between vestibular aqueduct (VA) measurements in the axial view and those in 45° oblique reformate in children with LVAS, and to define radiological criteria to diagnose LVA in the 45° oblique reformate.
  
  
  METHODS
  The study group included 61 children with LVAS according to Cincinnati criteria (greater than 0.9mm at the midpoint or greater than 1.9mm at the operculum in the axial view). All participants were subjected to full Audiological evaluation and CT scanning in axial plane. The axial data were then transferred to workstation for post-processing with 3D reformatting software (Baxara 3D) in order to obtain the 45° oblique reformates. VA measurements were done at 4 points: midpoint and operculum in both the axial plane and the 45° oblique reformate.
  
  
  RESULTS
  Only 81% of ears of children with LVAS (99 ears) fit Valvassori criterion (i.e., larger than 1.5mm at midpoint), while 19% (23 ears) of them were missed. There were statistically significant correlations among the diameters of the VA in the axial view (both in the midpoint and operculum) and their counterparts in the 45° oblique reformate. Values equal to or greater than 1.2mm in the midpoint and 1.3mm in the operculum are proposed to be the criteria to diagnose LVA in the 45° oblique reformate. Finally, no significant correlations were found between the degree of hearing loss and VA diameters at the axial or 45° oblique reformate.
  
  
  CONCLUSIONS
  Cincinnati criteria are more sensitive than Valvassori criterin in the diagnosis of LVAS. We recommend the application of Cincinnati criteria instead of Valvassori criteria in order not miss cases with LVAS. Measurement of VA in the 45° oblique reformate is a reliable method to diagnose LVA. Criteria to diagnose LVA in the 45° oblique reformate were proposed.
authors.affiliation: Otolaryngology Department, Audiology Unit, Minia University, Minia, Egypt. Electronic address: Mohamed.radi@mu.edu.eg.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: El-Badry
authors.affiliation: Radiology Department, Minia University, Minia, Egypt.
authors.forename: Nasr M
authors.initials: NM
authors.lastname: Osman
authors.affiliation: Otolaryngology Department, Phoniatric Unit, Minia University, Minia, Egypt.
authors.forename: Haytham Mamdouh
authors.initials: HM
authors.lastname: Mohamed
authors.affiliation: Otolaryngology Department, Audiology Unit, Minia University, Minia, Egypt.
authors.forename: Fatma M
authors.initials: FM
authors.lastname: Rafaat
mesh_terms: D000293:Adolescent; D001299:Audiometry; D002648:Child; D002675:Child, Preschool; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D012680:Sensitivity and Specificity; D013577:Syndrome; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014723:Vestibular Aqueduct / Q000002:abnormalities / Q000000981:diagnostic imaging*; D015837:Vestibular Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging*
keywords: 45° oblique reformate; CT scanning; Large vestibular aqueduct syndrome; Sensorineural hearing loss