title: Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV.
abstract: The pathogenesis of dengue in subjects coinfected with HIV remains largely unknown. We investigate clinical and immunological parameters in coinfected DENV/HIV patients. According to the new dengue classification, most coinfected DENV/HIV patients presented mild clinical manifestations of dengue infection. Herein, we show that DENV/HIV coinfected patients had higher CD8 T cells percentages reflected as a lower CD4/CD8 ratio. Furthermore, CCR5 expression on CD4 T cells and CD107a expression on both T subsets were significantly higher in coinfected patients when compared with monoinfected DENV and HIV individuals respectively. Increased inflammatory response was observed in treated HAART coinfected patients despite undetectable HIV load. These data indicate that DENV infection may influence the clinical profile and immune response in individuals concomitantly infected with HIV.
authors.affiliation: Laboratório de Imunologia Viral, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil. Electronic address: biotorrentes@gmail.com.
authors.forename: Amanda
authors.initials: A
authors.lastname: Torrentes-Carvalho
authors.affiliation: Instituto de Pesquisa clínica Evandro Chagas (IPEC), Rio de Janeiro, Brazil.
authors.forename: Eugênio Damaceno
authors.initials: ED
authors.lastname: Hottz
authors.affiliation: Laboratório de Imunologia Viral, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil.
authors.forename: Cintia Ferreira
authors.initials: CF
authors.lastname: Marinho
authors.affiliation: Laboratório de Imunologia Viral, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil.
authors.forename: Jéssica Badolato-Corrêa
authors.initials: JB
authors.lastname: da Silva
authors.affiliation: Laboratório de Imunologia Viral, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil.
authors.forename: Luzia Maria de Oliveira
authors.initials: LM
authors.lastname: Pinto
authors.affiliation: Laboratório de Imunologia Viral, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil.
authors.forename: Luciana Gomes
authors.initials: LG
authors.lastname: Fialho
authors.affiliation: Instituto de Pesquisa clínica Evandro Chagas (IPEC), Rio de Janeiro, Brazil.
authors.forename: Fernando Augusto
authors.initials: FA
authors.lastname: Bozza
authors.affiliation: Departamento de Clínica Médica, FM, Universidade Federal do Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Rivaldo Venâncio
authors.initials: RV
authors.lastname: Cunha
authors.affiliation: Hospital Universitário Gaffrée Guinle, Universidade Federal do Estado do Rio de Janeiro - UNI RIO, Rio de Janeiro, Brazil.
authors.forename: Paulo Vieira
authors.initials: PV
authors.lastname: Damasco
authors.affiliation: Laboratório de Imunologia Viral, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil.
authors.forename: Claire Fernandes
authors.initials: CF
authors.lastname: Kubelka
authors.affiliation: Laboratório de Imunologia Viral, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil. Electronic address: elzinandes@ioc.fiocruz.br.
authors.forename: Elzinandes Leal
authors.initials: EL
authors.lastname: de Azeredo
mesh_terms: D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D060085:Coinfection / Q000097:blood / Q000276:immunology*; D016207:Cytokines / Q000097:blood*; D003715:Dengue / Q000097:blood / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D016207:Cytokines
keywords: Coinfection; Cytokines; Dengue; HIV; Lymphocytes