title: Cardiac Sympathetic Hyperactivity in a Patient with Guillain-Barré Syndrome: An Analysis Using Cardiac [(123)I] Metaiodobenzylguanidine (MIBG) Scintigraphy.
abstract: A 31-year-old woman gradually developed weakness in the lower extremities and gait disturbance. Subsequently, the patient developed severe constipation and hypertension with tachycardia. Nerve conduction studies revealed demyelinating polyneuropathy. Serum anti-GQ1b IgG antibody was detected. The levels of plasma noradrenaline and dopamine and urinary noradrenaline were elevated. Cardiac [(123)I] metaiodobenzylguanidine (MIBG) scintigraphy showed a normal H/M rate at the early phase and an elevated washout rate. According to these findings, the patient was diagnosed with Guillain-Barré syndrome with cardiac sympathetic hyperactivity. During convalescence, the plasma and urine catecholamine levels fell within the reference ranges, and MIBG scintigraphy showed a decreased washout rate.
authors.affiliation: Department of Neurology, Gifu Municipal Hospital, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Satomi
mesh_terms: D019797:3-Iodobenzylguanidine / Q000008:administration & dosage*; D000328:Adult; D003248:Constipation / Q000209:etiology; D005260:Female; D020233:Gait Disorders, Neurologic / Q000209:etiology* / Q000503:physiopathology; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D009638:Norepinephrine / Q000627:therapeutic use*; D011115:Polyneuropathies / Q000209:etiology / Q000503:physiopathology*; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013566:Sympathomimetics / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D013566:Sympathomimetics; D019797:3-Iodobenzylguanidine; D009638:Norepinephrine