title: Clinical evaluation following the use of mineralized collagen graft for bone defects in revision total hip arthroplasty.
abstract: Revision total hip arthroplasty (THA) with massive bone loss has been a real challenge for orthopaedic surgeons. Here we describe an approach using mineralized collagen (MC) graft to reconstruct acetabulum and femur with massive bone defects. We identified 89 patients suffering acetabular or femoral bone defects after primary THA, who required revision THA for this study. During the surgery, MC was applied to reconstruct both the acetabular and femoral defects. Harris hip score was used to evaluate hip function while radiographs were taken to estimate bone formation in the defect regions. The average follow-up period was 33.6 ± 2.4 months. None of the components needed re-revised. Mean Harris hip scores were 42.5 ± 3.5 before operation, 75.2 ± 4.0 at 10th month and 95.0 ± 3.6 at the final follow-up. There were no instances of deep infection, severe venous thrombosis or nerve palsy. The present study demonstrated that MC graft can serve as a promising option for revision THA with massive bone deficiency. Meanwhile, extended follow-up is needed to further prove its long-term performance.
authors.affiliation: Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China and.
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Orthopaedics, Wendeng Orthopaedic Hospital of Shandong Province Affiliated to Shandong University of Traditional Chinese Medicine, Weihai 264400, China.
authors.forename: Liwu
authors.initials: L
authors.lastname: Qin
authors.affiliation: Department of Orthopaedics, Wendeng Orthopaedic Hospital of Shandong Province Affiliated to Shandong University of Traditional Chinese Medicine, Weihai 264400, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China and.
authors.forename: Xisheng
authors.initials: X
authors.lastname: Weng
authors.affiliation: Department of Orthopaedics, Wendeng Orthopaedic Hospital of Shandong Province Affiliated to Shandong University of Traditional Chinese Medicine, Weihai 264400, China.
authors.forename: Xiangjie
authors.initials: X
authors.lastname: Huang
keywords: bone defect; bone substitutes; mineralized collagen; revision; total hip arthroplasty
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