title: Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease.
abstract: OBJECTIVE
  The aim of this study was to evaluate the periaortic fat thickness (PAFT) using conventional echocardiography in obese children and adolescents with non-alcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  Two hundred and ninety-seven obese children and adolescents were included in the study. Anthropometric measurements were made in all subjects, and fasting venous blood samples were taken for determination of glucose, insulin, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Ultrasonography of the liver was used for assessment of NAFLD and the subjects were grouped as NAFLD and non-NAFLD. Echocardiography was performed in all subjects.
  
  
  RESULTS
  PAFT was higher in patients with NAFLD compared with the non-NAFLD group. In patients with NAFLD, PAFT was positively correlated with waist circumference and with total cholesterol levels. In multiple regression analysis, waist circumference (β=0.28, p=<0.001) was found to be the best predictor of PAFT.
  
  
  CONCLUSIONS
  Conventional echocardiography may be used to determine increased PAFT at an early stage in obese children and adolescents with NAFLD for careful monitoring of cardiovascular risk.
authors.affiliation: Necmettin Erbakan University Faculty of Medicine, Division of Pediatric Endocrinology and Diabetes, Konya, Turkey Phone: +90 332 223 63 50 E-mail: berayselver@hotmail.com.
authors.forename: Beray Selver
authors.initials: BS
authors.lastname: Eklioğlu
authors.forename: Mehmet Emre
authors.initials: ME
authors.lastname: Atabek
authors.forename: Nesibe
authors.initials: N
authors.lastname: Akyürek
authors.forename: Hayrullah
authors.initials: H
authors.lastname: Alp
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging; D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001011:Aorta / Q000000981:diagnostic imaging; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D002648:Child; D002784:Cholesterol / Q000097:blood; D004452:Echocardiography; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000150:complications; D063766:Pediatric Obesity / Q000097:blood* / Q000150:complications; D012044:Regression Analysis; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
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