title: A Heuristic Framework for Image Filtering and Segmentation: Application to Blood Vessel Immunohistochemistry.
abstract: The blood vessel density in a cancerous tissue sample may represent increased levels of tumor growth. However, identifying blood vessels in the histological (tissue) image is difficult and time-consuming and depends heavily on the observer's experience. To overcome this drawback, computer-aided image analysis frameworks have been investigated in order to boost object identification in histological images. We present a novel algorithm to automatically abstract the salient regions in blood vessel images. Experimental results show that the proposed framework is capable of deriving vessel boundaries that are comparable to those demarcated manually, even for vessel regions with weak contrast between the object boundaries and background clutter.
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 100, Taiwan.
authors.forename: Chi-Hsuan
authors.initials: CH
authors.lastname: Tsou
authors.affiliation: Department of Radiology, National Taiwan University College of Medicine and Department of Medical Imaging, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei 100, Taiwan.
authors.forename: Yi-Chien
authors.initials: YC
authors.lastname: Lu
authors.affiliation: Department of Internal Medicine, National Taiwan University College of Medicine, No. 7, Chung-Shan South Road, Taipei 100, Taiwan.
authors.forename: Ang
authors.initials: A
authors.lastname: Yuan
authors.affiliation: Department of Radiology, National Taiwan University College of Medicine and Department of Medical Imaging, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei 100, Taiwan.
authors.forename: Yeun-Chung
authors.initials: YC
authors.lastname: Chang
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 100, Taiwan.
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D001331:Automation; D001808:Blood Vessels / Q000473:pathology*; D045744:Cell Line, Tumor; D016000:Cluster Analysis; D017143:Fuzzy Logic; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D013194:Staining and Labeling
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