title: PDGFRs expression in dogs affected by malignant oral melanomas: correlation with prognosis.
abstract: Canine malignant melanoma (CMM) is the most common canine oral tumour, and up to 70-75% of dogs in stage II-III die within 1 year after surgery. The purpose of this study was to evaluate the expression of platelet-derived growth factors receptors (PDGFR)-α and -β in stage II and III CMMs and to correlate it with prognosis. PDGFRs expression was evaluated by immunohistochemistry on 48 cases of formalin-fixed CMM samples and correlated with clinical-pathological findings and outcome after surgery. PDGFRs co-expression was observed in 37.5% of cases. Positivity for PDGFR-α and -β receptor was present in 54.2 and 47.9% of cases, respectively. Ki67 values >19.5% were ascertained in 66.7% of cases. Statistical analysis showed that PDGFRs co-expression and Ki67 values > 19.5% were both associated with worse prognosis. PDGFRs expression suggests a role in the pathogenesis and progression of CMM, and α and β co-expression appears to be associated to worse prognosis.
authors.affiliation: Department of Veterinary Sciences, University of Turin, Turin, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Iussich
authors.affiliation: Department of Veterinary Sciences, University of Turin, Turin, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Maniscalco
authors.affiliation: Department of Veterinary Sciences, University of Turin, Turin, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Di Sciuva
authors.affiliation: Department of Veterinary Sciences, University of Turin, Turin, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Iotti
authors.affiliation: Department of Veterinary Sciences, University of Turin, Turin, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Morello
authors.affiliation: Department of Veterinary Sciences, University of Turin, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Martano
authors.affiliation: Department of Veterinary Sciences, University of Turin, Turin, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Gattino
authors.affiliation: Department of Veterinary Sciences, University of Turin, Turin, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Buracco
authors.affiliation: Department of Veterinary Sciences, University of Turin, Turin, Italy.
authors.forename: R
authors.initials: R
authors.lastname: De Maria
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000662:veterinary*; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000662:veterinary*; D011379:Prognosis; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000378:metabolism; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta; D017479:Receptors, Platelet-Derived Growth Factor
keywords: PDGF receptors; canine malignant melanoma; prognostic factor; targeted therapy