title: A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors.
abstract: A novel fluorescent probe for in vitro and in vivo imaging of dipeptidyl peptidase-4 (DPP-4) was designed and synthesized. This probe is successfully utilized to screen DPP-4 inhibitors in living 3T3-L1 cells and zebrafish, which provides a novel approach for the discovery of anti-diabetes drugs.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University (Zijingang Campus), Hangzhou, 310058, P. R. China. mysky@zju.edu.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Xueli
authors.initials: X
authors.lastname: Wu
authors.forename: Yiyu
authors.initials: Y
authors.lastname: Cheng
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhao
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D018819:Dipeptidyl Peptidase 4 / Q000737:chemistry*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D066298:In Vitro Techniques; D051379:Mice; D008856:Microscopy, Fluorescence; D015027:Zebrafish
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D005456:Fluorescent Dyes; D018819:Dipeptidyl Peptidase 4