title: Elevated Serum Concentration of Chitinase 3-Like 1 is an Independent Prognostic Biomarker for Poor Survival in Lung Cancer Patients.
abstract: OBJECTIVE
  The chitinase 3-like 1 (CHI3L1) has an important role in cancer progression, and high CHI3L1 expression is associated with the development and progression of cancers. Previous studies had been controversial with respect to the association between CHI3L1 expression and lung cancer prognosis. Thus, we performed a meta-analysis to investigate the prognostic value of CHI3L1 expression in lung cancer.
  
  
  METHODS
  We searched Pubmed, Embase, and Wanfang databases to identify eligible studies. Overall survival and disease free survival were collected from included studies. Pooled hazard ratios (HRs) with 95% confidence interval (95%CI) were calculated to estimate the association. Seven studies comprising 911 lung cancer patients were included in this meta-analysis.
  
  
  RESULTS
  The results showed high CHI3L1 expression was independently associated with poorer overall survival in lung cancer patients (HR = 1.71, 95%CI 1.24-2.37, P = 0.001). Subgroup analysis by histological type showed that high CHI3L1 expression was independently associated with poorer overall survival in both non small-cell lung cancer patients (HR = 2.23,95%CI 1.43-3.47, P < 0.001) and small-cell lung cancer patients (HR = 1.45, 95%CI 1.06-2.00, P = 0.021). In addition, sensitivity analysis by omitting single study by turns did not change the pooled outcomes obviously.
  
  
  CONCLUSIONS
  Our results suggest that elevated serum CHI3L1 concentration is an independent prognostic biomarker for poorer survival in lung cancer patients.
authors.affiliation: Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, PR China.
authors.forename: Jiying
authors.initials: J
authors.lastname: Wang
authors.forename: Zhaoying
authors.initials: Z
authors.lastname: Sheng
authors.forename: Wenyan
authors.initials: W
authors.lastname: Yang
authors.forename: Yong
authors.initials: Y
authors.lastname: Cai
mesh_terms: D054392:Adipokines / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000175:diagnosis; D000071451:Chitinase-3-Like Protein 1; D002688:Chitinases; D006801:Humans; D037102:Lectins / Q000097:blood*; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis; D011379:Prognosis; D055752:Small Cell Lung Carcinoma / Q000097:blood* / Q000175:diagnosis; D016019:Survival Analysis
chemical_list: D054392:Adipokines; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins; D002688:Chitinases