title: Functionalized β-cyclodextrin based potentiometric sensor for naproxen determination.
abstract: Potentiometric sensors based on neutral β-cyclodextrins: (2-hydroxypropyl)-β-cyclodextrin, heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin, heptakis(2,3,6-tri-O-benzoyl)-β-cyclodextrin and anionic β-cyclodextrin: (2-hydroxy-3-N,N,N-trimethylamino)propyl-β-cyclodextrin chloride for naproxen are described. Inclusion complexes of naproxen with the above-mentioned cyclodextrins were studied using IR spectroscopy. The electrode surface was made from PVC membranes doped with the appropriate β-cyclodextrin as ionophores and quaternary ammonium chlorides as positive charge additives that were dispersed in plasticizers. The optimum membrane contains heptakis(2,3,6-tri-O-benzoyl)-β-cyclodextrin, o-nitrophenyloctyl ether and tetraoctyl ammonium chloride as a lipophilic salt. The electrode is characterized by a Nernstian response slope of -59.0 ± 0.5 mV decade(-1) over the linear range of 5.0 × 10(-5)-1.0 × 10(-2) mol L(-1) and the detection limit 1.0 × 10(-5) mol L(-1), as well as the response time 10s. It can be used in the pH range 6.2-8.5 for 10 months without any considerable deterioration. Incorporation of β-cyclodextrins improved the electrode selectivity towards naproxen ions from several inorganic and organic interferents and some common drug excipients due to concovalent interactions (host molecule-guest molecule). The notable advantages of the naproxen-selective electrode include its high sensitivity, high selectivity, cost-effectiveness as well as accurate and comfortable application in drug analysis and milk samples.
authors.affiliation: Department of Analytical Chemistry and Instrumental Analysis, Faculty of Chemistry, Maria Curie-Skłodowska University, M. Curie-Skłodowska Sq. 3, Lublin 20-031, Poland. Electronic address: j.lenik@poczta.umcs.lublin.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Lenik
authors.affiliation: Department of General and Coordination Chemistry, Faculty of Chemistry, Maria Curie-Skłodowska University, M.C. Skłodowska Sq. 2, Lublin, Poland. Electronic address: renata.lyszczek@poczta.umcs.lublin.pl.
authors.forename: Renata
authors.initials: R
authors.lastname: Łyszczek
mesh_terms: D009288:Naproxen / Q000032:analysis*; D011199:Potentiometry / Q000379:methods; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D047392:beta-Cyclodextrins; D009288:Naproxen
keywords: IR spectroscopy; Inclusion complexes with naproxen; Naproxen electrode; Pharmaceutical analysis; β-cyclodextrins