title: Applying computation biology and "big data" to develop multiplex diagnostics for complex chronic diseases such as osteoarthritis.
abstract: The data explosion in the last decade is revolutionizing diagnostics research and the healthcare industry, offering both opportunities and challenges. These high-throughput "omics" techniques have generated more scientific data in the last few years than in the entire history of mankind. Here we present a brief summary of how "big data" have influenced early diagnosis of complex diseases. We will also review some of the most commonly used "omics" techniques and their applications in diagnostics. Finally, we will discuss the issues brought by these new techniques when translating laboratory discoveries to clinical practice.
authors.affiliation: a McCaig Institute for Bone & Joint Health, University of Calgary , Calgary , AB , Canada .
authors.forename: Guomin
authors.initials: G
authors.lastname: Ren
authors.affiliation: a McCaig Institute for Bone & Joint Health, University of Calgary , Calgary , AB , Canada .|b Department of Surgery , University of Calgary , Calgary , AB , Canada , and.|c Department of Anatomy and Cell Biology , University of Calgary , Calgary , AB , Canada.
authors.forename: Roman
authors.initials: R
authors.lastname: Krawetz
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D019295:Computational Biology / Q000379:methods*; D057225:Data Mining / Q000379:methods*; D016208:Databases, Factual; D005819:Genetic Markers; D023281:Genomics; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D010003:Osteoarthritis / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D049490:Systems Biology
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D011506:Proteins
keywords: Chronic disease; computational biology; diagnostics; osteoarthritis
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