title: The prognostic value of plasma Δ-copeptin levels in patients with isolated traumatic brain injury.
abstract: OBJECTIVE
  Traumatic brain injury (TBI) is one of the most common causes of death among trauma patients. Earlier prediction of possible poor neurological outcomes, even upon admission to the emergency department, may help to guide treatment. The aim of this prospective study was to assess the predictive value of plasma copeptin levels for early morbidity and mortality in patients with isolated TBI.
  
  
  METHODS
  This prospective study comprised 53 patients who were admitted to the emergency department with isolated TBI. Forty-two of these patients (group I) survived at least 1 month after the TBI; the other 11 (group II) did not. Plasma levels of copeptin were measured in these TBI patients at admission and 6 h after trauma, and were compared with those of healthy volunteers (group III).
  
  
  RESULTS
  At admission, the copeptin levels of the TBI patients (groups I and II combined) were not statistically significantly different from those of the control group (III). The copeptin levels 6 h after trauma were also not statistically significantly different from those at admission. Δ-Copeptin levels (the difference between the copeptin level at the 6th hour after trauma and that at admission) were higher in the patients who died within a month of the TBI. Further, Δ-copeptin levels were higher in patients who showed no improvement in the modified Rankin score when compared with patients with an improved modified Rankin score. The best cutoff point for Δ-copeptin was 0.51 ng/ml for predicting mortality and 0.23 ng/ml for predicting improvement in the modified Rankin score.
  
  
  CONCLUSIONS
  Plasma Δ-copeptin levels may help physicians predict the prognoses of patients suffering from traumatic brain injury.
authors.affiliation: Department of Emergency Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. acildrumut@yahoo.com.|, İrfan Bastug cad. S.B. Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi, Acil Tip Klinigi, 06110, Ankara, Turkey. acildrumut@yahoo.com.
authors.forename: U Y
authors.initials: UY
authors.lastname: Cavus
authors.affiliation: Department of Emergency Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yildirim
authors.affiliation: Department of Neurosurgery, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Gurer
authors.affiliation: Department of Emergency Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Dibek
authors.affiliation: Karabük State Hospital, Karabük, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Yilmaz
authors.affiliation: Department of Biochemistry, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Ozturk
authors.affiliation: Department of Emergency Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Buyukcam
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Bezmialem Vakıf Gureba University, Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Sonmez
keywords: Copeptin; Prognostic value; Traumatic brain injury; Δ-Copeptin
references.citation: Neurol Med Chir (Tokyo). 2012;52(1):1-30
references.pmid: 22278024
references.citation: Shock. 2007 Aug;28(2):219-26
references.pmid: 17515850
references.citation: Ulus Travma Acil Cerrahi Derg. 2010 Mar;16(2):119-24
references.pmid: 20517764
references.citation: Chest. 2007 Apr;131(4):1058-67
references.pmid: 17426210
references.citation: J Neurotrauma. 2007;24 Suppl 1:S37-44
references.pmid: 17511544
references.citation: Int J Stroke. 2013 Apr;8(3):214-8
references.pmid: 22336226
references.citation: J Rehabil Med. 2013 Sep;45(8):734-40
references.pmid: 24002308
references.citation: Vasc Health Risk Manag. 2011;7:509-15
references.pmid: 21915168
references.citation: J Clin Neurosci. 2001 Mar;8(2):120-3
references.pmid: 11484659
references.citation: Acta Neurochir Suppl. 2010;106:221-4
references.pmid: 19812953
references.citation: Ann Neurol. 2009 Dec;66(6):799-808
references.pmid: 20035506
references.citation: BMC Med. 2012 Jan 20;10:7
references.pmid: 22264220
references.citation: Stroke. 2007 May;38(5):1641-4
references.pmid: 17379820
references.citation: J Trauma. 2011 Nov;71(5):1194-8
references.pmid: 21502880
references.citation: Eur J Clin Invest. 2006 Nov;36(11):771-8
references.pmid: 17032344
references.citation: Shock. 2007 Dec;28(6):644-649
references.pmid: 18092379
references.citation: Trends Endocrinol Metab. 2008 Mar;19(2):43-9
references.pmid: 18291667
references.citation: Acta Neurochir (Wien). 2008 Mar;150(3):265-71
references.pmid: 18288441
references.citation: BMC Neurol. 2010 May 26;10:34
references.pmid: 20504314
references.citation: Stroke. 1993 Jul;24(7):987-93
references.pmid: 8322400
references.citation: Exp Ther Med. 2013 Feb;5(2):467-470
references.pmid: 23407763