title: Synthesis and characterization of a HAp-based biomarker with controlled drug release for breast cancer.
abstract: A biocompatible hybrid porous polymer-ceramic material was synthesized to be used as a biomarker in the treatment of breast cancer. This device was equipped with the capacity to release medicaments locally in a controlled manner. The biomaterial was Hydroxyapatite(HAp)-based and had a controlled pore size and pore volume fraction. It was implemented externally using a sharp end and a pair of barbed rings placed opposite each other to prevent relative movement once implanted. The biomarker was impregnated with cis-diamine dichloride platinum (II) [Cl2-Pt-(NH3)2]; the rate of release was obtained using inductively coupled plasma atomic emission spectroscopy (ICP-AES), and release occurred over the course of three months. Different release profiles were obtained as a function of the pore volume fraction. The biomaterial was characterized using scanning electron microscopy (SEM) and Raman spectroscopy.
authors.affiliation: Dept. of Molecular Engineering of Materials, Center of Applied Physics and Advanced Technology, National Autonomous University of Mexico (CFATA-UNAM), Boulevard Juriquilla 3001, Santiago de Querétaro, Querétaro 76230, Mexico.
authors.forename: Maykel
authors.initials: M
authors.lastname: González
authors.affiliation: Dept. of Molecular Engineering of Materials, Center of Applied Physics and Advanced Technology, National Autonomous University of Mexico (CFATA-UNAM), Boulevard Juriquilla 3001, Santiago de Querétaro, Querétaro 76230, Mexico; University of the Valley of Mexico (UVM), Boulevard Villas del Mesón 1000, Juriquilla, Santiago de Querétaro, Querétaro 76320, Mexico.
authors.forename: Ulises
authors.initials: U
authors.lastname: Merino
authors.affiliation: Dept. of Molecular Engineering of Materials, Center of Applied Physics and Advanced Technology, National Autonomous University of Mexico (CFATA-UNAM), Boulevard Juriquilla 3001, Santiago de Querétaro, Querétaro 76230, Mexico.
authors.forename: Susana
authors.initials: S
authors.lastname: Vargas
authors.affiliation: University of the Valley of Mexico (UVM), Boulevard Villas del Mesón 1000, Juriquilla, Santiago de Querétaro, Querétaro 76320, Mexico.
authors.forename: Francisco
authors.initials: F
authors.lastname: Quintanilla
authors.affiliation: Dept. of Molecular Engineering of Materials, Center of Applied Physics and Advanced Technology, National Autonomous University of Mexico (CFATA-UNAM), Boulevard Juriquilla 3001, Santiago de Querétaro, Querétaro 76230, Mexico. Electronic address: rogelior@unam.mx.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Rodríguez
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D002516:Ceramics / Q000737:chemistry; D002945:Cisplatin / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D065546:Drug Liberation; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D013059:Spectrum Analysis, Raman
chemical_list: D001672:Biocompatible Materials; D014408:Biomarkers, Tumor; D004337:Drug Carriers; D011108:Polymers; D017886:Durapatite; D002945:Cisplatin
keywords: Biomarkers; Breast cancer; Cisplatin; Drug controlled release; Implant