title: CD44, Sonic Hedgehog, and Gli1 Expression Are Prognostic Biomarkers in Gastric Cancer Patients after Radical Resection.
abstract: Aim. CD44 and Sonic Hedgehog (Shh) signaling are important for gastric cancer (GC). However, the clinical impact, survival, and recurrence outcome of CD44, Shh, and Gli1 expressions in GC patients following radical resection have not been elucidated. Patients and Methods. CD44, Shh, and Gli1 protein levels were quantified by immunohistochemistry (IHC). The association between CD44, Shh, and Gli1 expression and clinicopathological features or prognosis of GC patients was determined. The biomarker risk score was calculated by the IHC staining score of CD44, Shh, and Gli1 protein. Results. The IHC positive staining of CD44, Shh, and Gli1 proteins was correlated with larger tumour size, worse gross type and histological type, and advanced TNM stage, which also predicted shorter overall survival (OS) and disease-free survival (DFS) after radical resection. Multivariate analysis indicated the Gli1 protein and Gli1, CD44 proteins were predictive biomarkers for OS and DFS, respectively. If biomarker risk score was taken into analysis, it was the independent prognostic factor for OS and DFS. Conclusions. CD44 and Shh signaling are important biomarkers for tumour aggressiveness, survival, and recurrence in GC.
authors.affiliation: Division of Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Gastric Cancer Center, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Jian-Hui
authors.affiliation: Division of Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Gastric Cancer Center, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Zhai
authors.initials: Z
authors.lastname: Er-Tao
authors.affiliation: Division of Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Gastric Cancer Center, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Si-Le
authors.affiliation: Division of Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Gastric Cancer Center, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Hui
authors.affiliation: Division of Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Gastric Cancer Center, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Kai-Ming
authors.affiliation: Division of Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Gastric Cancer Center, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xin-Hua
authors.affiliation: Division of Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Gastric Cancer Center, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chuang-Qi
authors.affiliation: Division of Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Gastric Cancer Center, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Cai
authors.initials: C
authors.lastname: Shi-Rong
authors.affiliation: Division of Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Gastric Cancer Center, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: He
authors.initials: H
authors.lastname: Yu-Long
references.citation: J Biomed Sci. 2011 Jan 18;18:6
references.pmid: 21241512
references.citation: Br J Cancer. 2013 Jul 23;109(2):379-86
references.pmid: 23778530
references.citation: Cancer Lett. 2014 Mar 28;344(2):180-7
references.pmid: 24333726
references.citation: Oncol Rep. 2014 Feb;31(2):673-8
references.pmid: 24297371
references.citation: World J Gastroenterol. 2008 Nov 7;14(41):6376-81
references.pmid: 19009655
references.citation: Stem Cells. 2009 May;27(5):1006-20
references.pmid: 19415765
references.citation: Clin Cancer Res. 2012 Feb 1;18(3):869-81
references.pmid: 22142828
references.citation: Anticancer Res. 2009 Jun;29(6):2147-57
references.pmid: 19528475
references.citation: Cancer Lett. 2012 Oct 1;323(1):48-57
references.pmid: 22484470
references.citation: Pathol Int. 2012 Feb;62(2):112-9
references.pmid: 22243781
references.citation: BMC Gastroenterol. 2012 Jul 28;12:95
references.pmid: 22839505
references.citation: Tumour Biol. 2014 Feb;35(2):1357-63
references.pmid: 24081672
references.citation: Histopathology. 2013 Oct;63(4):474-81
references.pmid: 23889297
references.citation: Dig Dis Sci. 2013 Jan;58(1):132-9
references.pmid: 22878917
references.citation: Swiss Med Wkly. 2011 May 31;141:w13208
references.pmid: 21630164
references.citation: Int J Clin Exp Pathol. 2014 Jul 15;7(8):5144-53
references.pmid: 25197388
references.citation: Anticancer Res. 2013 May;33(5):2107-14
references.pmid: 23645762
references.citation: Carcinogenesis. 2011 Apr;32(4):445-51
references.pmid: 21186299
references.citation: Int J Cancer. 2010 Dec 15;127(12):2893-917
references.pmid: 21351269
references.citation: Lab Invest. 2010 Nov;90(11):1604-14
references.pmid: 20856229
references.citation: Clin Breast Cancer. 2013 Feb;13(1):7-15
references.pmid: 23127340
references.citation: Nat Cell Biol. 2011 Aug 21;13(9):1051-61
references.pmid: 21857669
references.citation: PLoS One. 2011 Mar 04;6(3):e17687
references.pmid: 21394208