title: Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation.
abstract: The GCN5-related N-acetyltransferases family (GNAT) is an important family of proteins that includes more than 100000 members among eukaryotes and prokaryotes. Acetylation appears as a major regulatory post-translational modification and is as widespread as phosphorylation. N-Acetyltransferases transfer an acetyl group from acetyl-CoA to a large array of substrates, from small molecules such as aminoglycoside antibiotics to macromolecules. Acetylation of proteins can occur at two different positions, either at the amino-terminal end (αN-acetylation) or at the ε-amino group (εN-acetylation) of an internal lysine residue. GNAT members have been classified into different groups on the basis of their substrate specificity, and in spite of a very low primary sequence identity, GNAT proteins display a common and conserved fold. This Current Topic reviews the different classes of bacterial GNAT proteins, their functions, their structural characteristics, and their mechanism of action.
authors.affiliation: Department of Biochemistry, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, New York 10461, United States.
authors.forename: Lorenza
authors.initials: L
authors.lastname: Favrot
authors.affiliation: Department of Biochemistry, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, New York 10461, United States.
authors.forename: John S
authors.initials: JS
authors.lastname: Blanchard
authors.affiliation: Department of Biochemistry, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, New York 10461, United States.
authors.forename: Olivia
authors.initials: O
authors.lastname: Vergnolle
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D019881:Aminoacyltransferases / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D000617:Aminoglycosides / Q000378:metabolism* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D001426:Bacterial Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D002473:Cell Wall / Q000378:metabolism*; D024881:Drug Resistance, Bacterial; D051548:Histone Acetyltransferases / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D063206:N-Terminal Acetyltransferases / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity; D000099224:p300-CBP-Associated Factor
chemical_list: D000123:Acetyltransferases; D019881:Aminoacyltransferases; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D051548:Histone Acetyltransferases; D063206:N-Terminal Acetyltransferases; D029701:Saccharomyces cerevisiae Proteins; C096686:FemA protein, Bacteria; C047195:N-epsilon-hydroxylysine acetyltransferase; C019681:aminoglycoside acetyltransferase; C501392:GCN5 protein, S cerevisiae; D000099224:p300-CBP-Associated Factor
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