title: Multiway analysis applied to time-resolved chemiluminescence for simultaneous determination of paracetamol and codeine in pharmaceuticals.
abstract: This method is based on the enhancing effect of codeine (COD) and paracetamol (PAR) on the chemiluminescence (CL) reaction of Ru(phen)3 (2+) with Ce(IV). In the batch mode, COD gives a relatively sharp peak with the highest CL intensity at 4.0 s, whereas the maximum CL intensity of the PAR appears at ~60 s after injection of Ce(IV) solution. Whole CL time profiles allowed use of the time-resolved CL data in combination with multiway calibration techniques, as multiway partial least squares (N-PLS), for the quantitative determination of both COD and PAR in binary mixtures. In this work, we found that the impact of Ce(IV) concentration on the CL intensity was different for COD and PAR. Therefore, a Ce(IV) concentration mode was added to the time and sample modes to obtain 3D data. The percent relative standard deviation (%RSD) values for 10 determinations of 1.0 × 10(-5)  mol/L of COD and 1.0 × 10(-4)  mol/L of PAR were 6.1% and 8.7%, respectively. The limit of detection (LOD) values (S/N = 3) were 0.9 × 10(-8)  mol/L and 1.0 × 10(-6)  mol/L for COD and PAR, respectively. The proposed method was successfully applied to the determination of PAR and COD in commercial pharmaceutical formulations. Acceptable recoveries (90-110%) were obtained for the quantification of these drugs in the real samples. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Science, Golestan University, Gorgan, Islamic Republic of Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Mokhtari
authors.affiliation: Department of Chemistry, Payame Noor University, Behshahr, Islamic Republic of Iran.
authors.forename: Nastaran
authors.initials: N
authors.lastname: Jafari Delouei
authors.affiliation: Department of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan, Islamic Republic of Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Keyvanfard
authors.affiliation: Department of Water Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Islamic Republic of Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdolhosseini
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D003061:Codeine / Q000032:analysis*; D007700:Kinetics; D049449:Luminescence; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations; D000082:Acetaminophen; D003061:Codeine
keywords: N-way partial least squares (N-PLS); chemiluminescence; codeine; paracetamol; simultaneous determination