title: Application of Tapping-Mode Scanning Probe Electrospray Ionization to Mass Spectrometry Imaging of Additives in Polymer Films.
abstract: We report the application of tapping-mode scanning probe electrospray ionization (t-SPESI) to mass spectrometry imaging of industrial materials. The t-SPESI parameters including tapping solvent composition, solvent flow rate, number of tapping at each spot, and step-size were optimized using a quadrupole mass spectrometer to improve mass spectrometry (MS) imaging of thin-layer chromatography (TLC) and additives in polymer films. Spatial resolution of approximately 100 μm was achieved by t-SPESI imaging mass spectrometry using a fused-silica capillary (50 μm i.d., 150 μm o.d.) with the flow rate set at 0.2 μL/min. This allowed us to obtain discriminable MS imaging profiles of three dyes separated by TLC and the additive stripe pattern of a PMMA model film depleted by UV irradiation.
authors.affiliation: Faculty of Chemistry, Materials and Bioengineering, Kansai University.
authors.forename: Ryo
authors.initials: R
authors.lastname: Shimazu
authors.affiliation: Faculty of Chemistry, Materials and Bioengineering, Kansai University.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Yamoto
authors.affiliation: Faculty of Chemistry, Materials and Bioengineering, Kansai University.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kosaka
authors.affiliation: Faculty of Chemistry, Materials and Bioengineering, Kansai University.
authors.forename: Hideya
authors.initials: H
authors.lastname: Kawasaki
authors.affiliation: Faculty of Chemistry, Materials and Bioengineering, Kansai University.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Arakawa
keywords: MS imaging; TLC; ambient ionization; polymer films; tapping-mode scanning probe electrospray ionization (t-SPESI)
references.citation: J Mass Spectrom. 2009 Oct;44(10):1469-77
references.pmid: 19685483
references.citation: Anal Bioanal Chem. 2012 Aug;404(2):389-98
references.pmid: 22706326
references.citation: Chem Rev. 2013 Apr 10;113(4):2309-42
references.pmid: 23394164
references.citation: Chem Rev. 2010 May 12;110(5):3237-77
references.pmid: 20423155
references.citation: Rapid Commun Mass Spectrom. 2007;21(18):3139-44
references.pmid: 17708527
references.citation: Biochim Biophys Acta. 2011 Nov;1811(11):961-9
references.pmid: 21440085
references.citation: Anal Chem. 2001 Feb 1;73(3):632-8
references.pmid: 11217773
references.citation: Analyst. 2014 May 21;139(10):2336-41
references.pmid: 24683596
references.citation: J Mass Spectrom. 2010 Mar;45(3):252-60
references.pmid: 20020414
references.citation: Anal Chem. 2010 Oct 1;82(19):7979-86
references.pmid: 20666445
references.citation: Anal Chem. 2011 Jun 15;83(12):4508-38
references.pmid: 21495690
references.citation: Science. 2004 Oct 15;306(5695):471-3
references.pmid: 15486296
references.citation: J Am Soc Mass Spectrom. 2012 Oct;23(10):1741-9
references.pmid: 22847392
references.citation: Analyst. 2010 Sep;135(9):2233-6
references.pmid: 20593081
references.citation: Science. 2006 Mar 17;311(5767):1566-70
references.pmid: 16543450
references.citation: J Chromatogr A. 2010 Jun 18;1217(25):3946-54
references.pmid: 20223463
references.citation: Mass Spectrom Rev. 2013 May-Jun;32(3):218-43
references.pmid: 22996621
references.citation: Anal Chem. 2014 Mar 18;86(6):3146-52
references.pmid: 24606410
references.citation: Rapid Commun Mass Spectrom. 2012 Dec 15;26(23):2725-32
references.pmid: 23124662