title: Hypersensitivity reactions associated with L-asparaginase administration in 142 dogs and 68 cats with lymphoid malignancies: 2007-2012.
abstract: Clinically significant hypersensitivity reactions (HSRs) to the chemotherapy drug L-asparaginase are reported in humans and dogs, but frequency in small animals is not well-defined. This study retrospectively evaluated the frequency of HSR to L-asparaginase given by IM injection to dogs and cats with lymphoid malignancies. The medical records of all dogs and cats treated with at least 1 dose of L-asparaginase chemotherapy over a 5-year period were reviewed. A total of 370 doses of L-asparaginase were administered to the dogs, with 88 of 142 dogs receiving multiple doses, and 6 dogs experiencing an HSR. A total of 197 doses were administered to the cats, with 33 of 68 cats receiving multiple doses, and no cats experiencing an HSR. Hypersensitivity reactions were documented in 4.2% of dogs, and in association with 1.6% of L-asparaginase doses administered. These results show that HSRs occur uncommonly among dogs and cats, even with repeated dosing.
authors.affiliation: VCA West Coast Specialty and Emergency Animal Hospital, 18300 Euclid Street, Fountain Valley, California 92708, USA (Blake); Veterinary Orthopedic & Sports Medicine Group, 10975 Guilford Road, Annapolis Junction, Maryland 20701, USA (Carr); Western Veterinary Specialist and Emergency Centre, 1802 10th Avenue SW, Calgary, Alberta T3C 0J8 (Mauldin).
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Blake
authors.affiliation: VCA West Coast Specialty and Emergency Animal Hospital, 18300 Euclid Street, Fountain Valley, California 92708, USA (Blake); Veterinary Orthopedic & Sports Medicine Group, 10975 Guilford Road, Annapolis Junction, Maryland 20701, USA (Carr); Western Veterinary Specialist and Emergency Centre, 1802 10th Avenue SW, Calgary, Alberta T3C 0J8 (Mauldin).
authors.forename: Brittany J
authors.initials: BJ
authors.lastname: Carr
authors.affiliation: VCA West Coast Specialty and Emergency Animal Hospital, 18300 Euclid Street, Fountain Valley, California 92708, USA (Blake); Veterinary Orthopedic & Sports Medicine Group, 10975 Guilford Road, Annapolis Junction, Maryland 20701, USA (Carr); Western Veterinary Specialist and Emergency Centre, 1802 10th Avenue SW, Calgary, Alberta T3C 0J8 (Mauldin).
authors.forename: Glenna E
authors.initials: GE
authors.lastname: Mauldin
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000009:adverse effects*; D002371:Cat Diseases / Q000139:chemically induced* / Q000188:drug therapy; D002415:Cats; D003520:Cyclophosphamide / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000662:veterinary*; D008223:Lymphoma / Q000188:drug therapy / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D001215:Asparaginase; D011241:Prednisone
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