title: Reversible airway obstruction in cystic fibrosis: Common, but not associated with characteristics of asthma.
abstract: As asthma-like symptoms are common in CF, we evaluated reversible airway obstruction and associated characteristics.
  
  
  
  Retrospective analysis of charts including spirometry and bronchodilator response.
  
  
  
  Of 190 CF patients (103 at Schneider's, 87 at Hadassah), aged 14.4 (4-76) years, median (range), 39% had reversible obstruction (ΔFEV1% predicted ≥12%), associated with younger age (p=0.01) and severe genotype (p=0.02). There was no association with family history of asthma, serum IgE, blood eosinophils, pancreatic status, FEV1<40% predicted, Aspergillus or pseudomonas infection. Of patients with reversible obstruction, 74% were on bronchodilator and 68% on inhaled corticosteroid therapy but 54% and 57% respectively receiving these therapies did not have reversible obstruction.
  
  
  
  Reversible airway obstruction is common in CF, more frequent in younger patients and with severe genotype, with no correlation to markers of atopy or CF clinical severity. Bronchodilator and inhaled corticosteroid therapies are commonly prescribed even without reversible obstruction.
authors.affiliation: Pulmonary Institute and Graub Cystic Fibrosis Center, Schneider Children's Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
authors.forename: Hagit
authors.initials: H
authors.lastname: Levine
authors.affiliation: CF Center, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Hebrew University Hadassah Medical School, Jerusalem, Israel.
authors.forename: Malena
authors.initials: M
authors.lastname: Cohen-Cymberknoh
authors.affiliation: Hebrew University Hadassah Medical School, Jerusalem, Israel.
authors.forename: Nitai
authors.initials: N
authors.lastname: Klein
authors.affiliation: Clalit research institute, Clalit health services, Tel-Aviv, Israel.
authors.forename: Moshe
authors.initials: M
authors.lastname: Hoshen
authors.affiliation: Pulmonary Institute and Graub Cystic Fibrosis Center, Schneider Children's Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
authors.forename: Huda
authors.initials: H
authors.lastname: Mussaffi
authors.affiliation: Pulmonary Institute and Graub Cystic Fibrosis Center, Schneider Children's Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
authors.forename: Patrick
authors.initials: P
authors.lastname: Stafler
authors.affiliation: CF Center, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Hebrew University Hadassah Medical School, Jerusalem, Israel.
authors.forename: Oded
authors.initials: O
authors.lastname: Breuer
authors.affiliation: CF Center, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Hebrew University Hadassah Medical School, Jerusalem, Israel.
authors.forename: Eitan
authors.initials: E
authors.lastname: Kerem
authors.affiliation: Pulmonary Institute and Graub Cystic Fibrosis Center, Schneider Children's Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. Electronic address: hblau@post.tau.ac.il.
authors.forename: Hannah
authors.initials: H
authors.lastname: Blau
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000368:Aged; D000402:Airway Obstruction / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D001249:Asthma / Q000175:diagnosis*; D001682:Biological Availability; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D005541:Forced Expiratory Volume; D005938:Glucocorticoids / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D013147:Spirometry / Q000379:methods; D013223:Statistics as Topic
chemical_list: D001993:Bronchodilator Agents; D005938:Glucocorticoids
keywords: Airway obstruction; Asthma; Bronchodilator; Cystic fibrosis; Hyperreactivity; Reversibility