title: The Importance of Timing.
abstract: Building a nervous system requires a precise sequence of genetic transitions, mediated in part by the temporal and spatial regulation of transcription factors. Quan et al. add to our understanding of this regulation by describing an evolutionarily conserved post-translational mechanism that rapidly extinguishes proneural protein activity in neural precursors.
authors.affiliation: Departments of Biochemistry and Molecular Biophysics and Systems Biology, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA. Electronic address: rsm10@cumc.columbia.edu.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Mann
authors.affiliation: Department of Biochemistry and Molecular Biophysics, Zuckerman Mind Brain Behavior Institute, Medical Scientist Training Program, Columbia University, New York, NY 10027, USA.
authors.forename: Clare E
authors.initials: CE
authors.lastname: Howard
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000737:chemistry* / Q000235:genetics*; D055495:Neurogenesis
chemical_list: D051792:Basic Helix-Loop-Helix Proteins