title: Bidirectional Transfer of Raltegravir in an Ex Vivo Human Cotyledon Perfusion Model.
abstract: Placental transfer of the HIV integrase inhibitor raltegravir (RLT) was investigated in term human cotyledons in the maternal-to-fetal (n = 3) and fetal-to-maternal (n = 6) directions. In the maternal-to-fetal direction, the mean ± standard deviation (SD) fetal transfer rate (FTR) was 9.1% ± 1.4%, and the mean ± SD clearance index (IC), i.e., RLT FTR/antipyrine FTR, was 0.28 ± 0.05. In the fetal-to-maternal direction, the mean ± SD CI was 0.31 ± 0.09. Placental transfer of RLT was high in both directions.
authors.affiliation: EA 3620, Université Paris Descartes, Paris, France Unité de Recherche Clinique Cochin Necker/CIC 0901, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France Risk in Pregnancy University Department, Paris, France.
authors.forename: Cécile
authors.identifier: 0000-0002-4242-2696
authors.initials: C
authors.lastname: Vinot
authors.affiliation: EA 3620, Université Paris Descartes, Paris, France Unité de Recherche Clinique Cochin Necker/CIC 0901, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France Risk in Pregnancy University Department, Paris, France Service de Pharmacologie Clinique, Hôpitaux Universitaires Paris Centre Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Tréluyer
authors.affiliation: EA 3620, Université Paris Descartes, Paris, France Unité de Recherche Clinique Cochin Necker/CIC 0901, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Giraud
authors.affiliation: Risk in Pregnancy University Department, Paris, France Service de Gynécologie et Obstétrique, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France Université Paris-Diderot, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Gavard
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Clinical Pharmaco-Toxicology Department, Hôpitaux Universitaires Paris-Nord Val de Seine, Paris, France IAME, UMR 1137, INSERM, Paris, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.affiliation: Risk in Pregnancy University Department, Paris, France Service de Gynécologie et Obstétrique, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France Université Paris-Diderot, Paris, France INSERM CESP 1019, Kremlin-Bicêtre, France laurent.mandelbrot@aphp.fr.
authors.forename: Laurent
authors.identifier: 0000-0002-5883-7597
authors.initials: L
authors.lastname: Mandelbrot
mesh_terms: D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D019428:HIV Integrase Inhibitors / Q000378:metabolism*; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000502:physiology; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D000068898:Raltegravir Potassium / Q000378:metabolism*
chemical_list: D019428:HIV Integrase Inhibitors; D000068898:Raltegravir Potassium
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