title: Layer-by-layer coating of textile with two oppositely charged cyclodextrin polyelectrolytes for extended drug delivery.
abstract: The coating of a nonwoven textile by polyelectrolyte multilayer film (PEM) issued from cationic and anionic β-cyclodextrin (βCD) polyelectrolytes according to the layer-by-layer (LbL) technique was successfully attempted. The tert-butyl benzoic acid (TBBA) was used as drug model to evaluate the loading capacity and sustained release properties of this PEM system. The build-up of the multilayer assembly was monitored in situ by optical waveguide lightmode spectroscopy (OWLS) on the one hand, and was assessed by gravimetry on the other hand when applied onto the textile substrate. In parallel, the complexation study of TBBA with both CD polyelectrolytes was also investigated by nuclear magnetic resonance (NMR) and isothermal titration calorimetry (ITC). The influence of thermal crosslinking of the multilayered coating on its stability and on TBBA release kinetics in phosphate buffered saline (PBS) at 37°C was studied. Finally, biological and microbiological tests were performed to investigate the cytocompatibility and the intrisic antibacterial activity of multilayer assemblies. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1408-1424, 2016.
authors.affiliation: Université Lille 1, Unité Matériaux Et Transformations (UMET) UMR CNRS 8207, Villeneuve D'ascq, France.
authors.forename: Jatupol
authors.initials: J
authors.lastname: Junthip
authors.affiliation: Université Lille 1, Unité Matériaux Et Transformations (UMET) UMR CNRS 8207, Villeneuve D'ascq, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Tabary
authors.affiliation: INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France.
authors.forename: Feng
authors.initials: F
authors.lastname: Chai
authors.affiliation: Université De Montpellier, Institut Des Biomolécules Max Mousseron (IBMM), UMR CNRS 5247, Montpellier, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Leclercq
authors.affiliation: INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France.
authors.forename: Mickael
authors.initials: M
authors.lastname: Maton
authors.affiliation: Université Lille 1, Unité Matériaux Et Transformations (UMET) UMR CNRS 8207, Villeneuve D'ascq, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Cazaux
authors.affiliation: Inserm U995-Team 1, Faculté Des Sciences Pharmaceutiques Et Biologiques, Lille, France.
authors.forename: Christel
authors.initials: C
authors.lastname: Neut
authors.affiliation: Université Lille 1, Unité Matériaux Et Transformations (UMET) UMR CNRS 8207, Villeneuve D'ascq, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Paccou
authors.affiliation: Université Lille 1, Unité Matériaux Et Transformations (UMET) UMR CNRS 8207, Villeneuve D'ascq, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Guinet
authors.affiliation: Université Lille 1, Unité Matériaux Et Transformations (UMET) UMR CNRS 8207, Villeneuve D'ascq, France.
authors.forename: Jean-Noel
authors.initials: JN
authors.lastname: Staelens
authors.affiliation: Université Lille 1, Centre Commun De Mesures RMN, Villeneuve D'ascq, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Bria
authors.affiliation: Université Du Littoral Côte D'opale, UCEIV, Dunkerque, France.
authors.forename: David
authors.initials: D
authors.lastname: Landy
authors.affiliation: Université Lille 1, Unité Matériaux Et Transformations (UMET) UMR CNRS 8207, Villeneuve D'ascq, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Hédoux
authors.affiliation: INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Blanchemain
authors.affiliation: Université Lille 1, Unité Matériaux Et Transformations (UMET) UMR CNRS 8207, Villeneuve D'ascq, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Martel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry; D002151:Calorimetry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000737:chemistry; D016503:Drug Delivery Systems; D004811:Epichlorohydrin / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D000071228:Polyelectrolytes / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013784:Textiles; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001565:Benzoates; D003432:Cross-Linking Reagents; D000071228:Polyelectrolytes; D047392:beta-Cyclodextrins; D004811:Epichlorohydrin; C034290:4-tert-butylbenzoic acid
keywords: citric acid; drug delivery system; epichlorohydrin; glycidyltrimethylammonium chloride; layer-by-layer; polyelectrolytes multilayer (PEM); textile; β-cyclodextrin polymer