title: The kinome 'at large' in cancer.
abstract: Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome 'at large' in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.
authors.affiliation: Department of Medical Oncology, Radboud University Medical Centre, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands.
authors.forename: Emmy D G
authors.initials: ED
authors.lastname: Fleuren
authors.affiliation: Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.|Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.|University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: Luxi
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Cancer Division, Kinghorn Cancer Centre, Garvan Institute of Medical Research, 370 Victoria Street, Sydney, New South Wales 2010, Australia.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wu
authors.affiliation: Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.|Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Daly
mesh_terms: D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D057166:High-Throughput Screening Assays; D051548:Histone Acetyltransferases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D009154:Mutation; D000072379:NIMA-Related Kinases; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D040901:Proteomics / Q000379:methods; D035381:TATA-Binding Protein Associated Factors / Q000235:genetics / Q000378:metabolism; D035362:Transcription Factor TFIID / Q000235:genetics / Q000378:metabolism
chemical_list: D035381:TATA-Binding Protein Associated Factors; D035362:Transcription Factor TFIID; D051548:Histone Acetyltransferases; D011494:Protein Kinases; C462119:NEK9 protein, human; D000072379:NIMA-Related Kinases; D017346:Protein Serine-Threonine Kinases; C069001:TATA-binding protein associated factor 250 kDa
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