title: Screening of Panamanian Plant Extracts for Pesticidal Properties and HPLC-Based Identification of Active Compounds.
abstract: A library of 600 taxonomically diverse Panamanian plant extracts was screened for fungicidal, insecticidal, and herbicidal activities. A total of 19 active extracts were submitted to HPLC-based activity profiling, and extracts of Bocconia frutescens, Miconia affinis, Myrcia splendens, Combretum aff. laxum, and Erythroxylum macrophyllum were selected for the isolation of compounds. Chelerythrine (2), macarpine (3), dihydrosanguinarine (5), and arjunolic acid (8) showed moderate-to-good fungicidal activity. Myricetin-3-O-(6''-O-galloyl)-β-galactopyranoside (13) showed moderate insecticidal activity, but no compound with herbicidal activity was identified.
authors.affiliation: Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
authors.forename: Niels
authors.initials: N
authors.lastname: Guldbrandsen
authors.affiliation: Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
authors.forename: Maria
authors.initials: M
authors.lastname: De Mieri
authors.affiliation: CIFLORPAN, College of Pharmacy, University of Panama, Apartado 0824-00172, Panama, Republic of Panama.
authors.forename: Mahabir
authors.initials: M
authors.lastname: Gupta
authors.affiliation: BASF SE, Carl-Bosch-Strasse 38, D-67056 Ludwigshafen, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Seiser
authors.affiliation: BASF SE, Carl-Bosch-Strasse 38, D-67056 Ludwigshafen, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Wiebe
authors.affiliation: BASF SE, Carl-Bosch-Strasse 38, D-67056 Ludwigshafen, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Dickhaut
authors.affiliation: BASF SE, Carl-Bosch-Strasse 38, D-67056 Ludwigshafen, Germany.
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Reingruber
authors.affiliation: BASF SE, Carl-Bosch-Strasse 38, D-67056 Ludwigshafen, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Sorgenfrei
authors.affiliation: Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Hamburger
keywords: Fungicide; HPLC-based activity profiling; Herbicide; Insecticide; Panamanian plant extracts
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