title: Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands.
abstract: The endocannabinoid system, through cannabinoid (CB) receptors, is involved in memory-related responses, as well as in processes that may affect cognition, like oxidative stress processes. The purpose of the experiments was to investigate the impact of CB1 and CB2 receptor ligands on the long-term memory stages in male Swiss mice, using the passive avoidance (PA) test, as well as the influence of these compounds on the level of oxidative stress biomarkers in the mice brain. A single injection of a selective CB1 receptor antagonist, AM 251, improved long-term memory acquisition and consolidation in the PA test in mice, while a mixed CB1/CB2 receptor agonist WIN 55,212-2 impaired both stages of cognition. Additionally, JWH 133, a selective CB2 receptor agonist, and AM 630, a competitive CB2 receptor antagonist, significantly improved memory. Additionally, an acute administration of the highest used doses of JWH 133, WIN 55,212-2, and AM 630, but not AM 251, increased total antioxidant capacity (TAC) in the brain. In turn, the processes of lipids peroxidation, expressed as the concentration of malondialdehyde (MDA), were more advanced in case of AM 251. Thus, some changes in the PA performance may be connected with the level of oxidative stress in the brain.
authors.affiliation: Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a Street, 20-093 Lublin, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Kruk-Slomka
authors.affiliation: Department of Medical Chemistry, Medical University of Lublin, Chodzki 4a Street, 20-093 Lublin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Boguszewska-Czubara
authors.affiliation: Department of Mathematics and Medical Biostatistics, Medical University of Lublin, Jaczewskiego 4 Street, 20-954 Lublin, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Slomka
authors.affiliation: Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a Street, 20-093 Lublin, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Budzynska
authors.affiliation: Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a Street, 20-093 Lublin, Poland.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Biala
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D048588:Benzoxazines / Q000494:pharmacology; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002186:Cannabinoids / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D009025:Morpholines / Q000494:pharmacology; D009281:Naphthalenes / Q000494:pharmacology; D018384:Oxidative Stress / Q000502:physiology*; D010880:Piperidines / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists / Q000037:antagonists & inhibitors*; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists / Q000037:antagonists & inhibitors*
chemical_list: D048588:Benzoxazines; D015415:Biomarkers; D002186:Cannabinoids; D007211:Indoles; D009025:Morpholines; D009281:Naphthalenes; D010880:Piperidines; D011720:Pyrazoles; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2; C103505:AM 251; D008315:Malondialdehyde; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone; C432747:1,1-dimethylbutyl-1-deoxy-Delta(9)-THC; C094023:iodopravadoline
references.citation: J Neuroinflammation. 2011;8(1):5
references.pmid: 21244691
references.citation: Hippocampus. 2010 Oct;20(10):1126-38
references.pmid: 19830813
references.citation: Physiol Rev. 2009 Jan;89(1):309-80
references.pmid: 19126760
references.citation: Br J Pharmacol. 2012 Apr;165(8):2561-74
references.pmid: 21615724
references.citation: Pharmacol Ther. 1997;74(2):129-80
references.pmid: 9336020
references.citation: Learn Mem. 2000 May-Jun;7(3):132-9
references.pmid: 10837502
references.citation: Neurochem Res. 2015 May;40(5):1083-93
references.pmid: 25862193
references.citation: Ital J Biochem. 2003 Dec;52(4):177-81
references.pmid: 15141484
references.citation: Proc Natl Acad Sci U S A. 2013 May 7;110(19):7904-9
references.pmid: 23610434
references.citation: J Physiol Pharmacol. 2009 Jun;60(2):113-22
references.pmid: 19617654
references.citation: J Pharmacol Exp Ther. 1998 Mar;284(3):858-67
references.pmid: 9495843
references.citation: Br J Pharmacol. 2012 Feb;165(4):951-64
references.pmid: 21838753
references.citation: Psychopharmacology (Berl). 2008 Jul;198(4):551-63
references.pmid: 18049812
references.citation: Br J Pharmacol. 2007 Nov;152(5):655-62
references.pmid: 17828287
references.citation: J Neurosci. 2011 Apr 6;31(14):5300-12
references.pmid: 21471365
references.citation: Pharmacotherapy. 2013 Feb;33(2):195-209
references.pmid: 23386598
references.citation: Brain. 2009 Nov;132(Pt 11):3152-64
references.pmid: 19805493
references.citation: Neurosci Lett. 2015 Feb 5;587:126-31
references.pmid: 25529196
references.citation: Expert Rev Clin Pharmacol. 2009 Nov;2(6):645-60
references.pmid: 22112258
references.citation: Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3254-63
references.pmid: 23108544
references.citation: Neurosci Lett. 2005 Jun 3;380(3):270-5
references.pmid: 15862900
references.citation: Neurobiol Learn Mem. 2002 Nov;78(3):637-47
references.pmid: 12559841
references.citation: Eur J Biochem. 1996 May 1;237(3):704-11
references.pmid: 8647116
references.citation: Neurobiol Learn Mem. 2014 Jul;112:30-43
references.pmid: 24382324
references.citation: Physiol Behav. 2013 Oct 2;122:46-55
references.pmid: 23999469
references.citation: Br J Pharmacol. 1999 Feb;126(3):665-72
references.pmid: 10188977
references.citation: ACS Chem Neurosci. 2012 May 16;3(5):369-78
references.pmid: 22860205
references.citation: Nutrition. 2010 Jun;26(6):595-603
references.pmid: 20083385
references.citation: J Neurosci. 2003 Feb 15;23(4):1398-405
references.pmid: 12598628
references.citation: Eur J Pharmacol. 2008 Aug 20;590(1-3):246-9
references.pmid: 18602386
references.citation: Addict Biol. 2008 Sep;13(3-4):345-57
references.pmid: 18782382
references.citation: Learn Mem. 2006 Jul-Aug;13(4):426-30
references.pmid: 16882859
references.citation: Science. 2005 Oct 14;310(5746):329-32
references.pmid: 16224028
references.citation: Curr Pharm Des. 2010;16(25):2766-78
references.pmid: 20698820
references.citation: Brain Res. 1991 May 3;547(2):267-74
references.pmid: 1909204
references.citation: J Neurosci. 2000 Apr 1;20(7):2470-9
references.pmid: 10729327
references.citation: Eur J Pharmacol. 2011 Jan 10;650(1):240-8
references.pmid: 20951129
references.citation: Toxicol Appl Pharmacol. 2007 Aug 15;223(1):73-85
references.pmid: 17618662
references.citation: Eur J Nutr. 2013 Sep;52(6):1553-67
references.pmid: 23744025
references.citation: J Lipid Res. 2010 Aug;51(8):2181-90
references.pmid: 20305287
references.citation: Nat Rev Drug Discov. 2004 Sep;3(9):771-84
references.pmid: 15340387
references.citation: Eur J Pharmacol. 2003 Sep 23;477(3):213-7
references.pmid: 14522359
references.citation: Behav Pharmacol. 2011 Oct;22(7):645-54
references.pmid: 21918382
references.citation: Psychopharmacology (Berl). 1996 Jul;126(2):165-72
references.pmid: 8856836
references.citation: Neuroscience. 2007 May 25;146(3):1212-9
references.pmid: 17383106
references.citation: Brain Res. 2012 Jan 6;1429:61-71
references.pmid: 21875703
references.citation: Neurosci Res. 2011 Jan;69(1):51-9
references.pmid: 20888871
references.citation: Neurosci Lett. 2000 Jan 14;278(3):157-60
references.pmid: 10653017
references.citation: J Mol Endocrinol. 2010 Feb;44(2):75-85
references.pmid: 19620237
references.citation: J Neurochem. 2002 Feb;80(3):448-56
references.pmid: 11905991
references.citation: Free Radic Biol Med. 2014 Sep;74:50-63
references.pmid: 24960578
references.citation: Biol Psychiatry. 2011 Sep 1;70(5):479-86
references.pmid: 21684528
references.citation: Behav Pharmacol. 2004 Feb;15(1):21-7
references.pmid: 15075623
references.citation: Nutr Neurosci. 2015 Jul;18(5):210-6
references.pmid: 24559058
references.citation: Brain Res. 2007 Jan 5;1127(1):36-44
references.pmid: 17113043
references.citation: J Leukoc Biol. 2007 Sep;82(3):532-41
references.pmid: 17537989
references.citation: Neurosci Bull. 2014 Apr;30(2):271-81
references.pmid: 24664866
references.citation: Anal Biochem. 1996 Jul 15;239(1):70-6
references.pmid: 8660627
references.citation: Neuroscience. 2008 Feb 19;151(4):929-36
references.pmid: 18248907
references.citation: Eur J Pharmacol. 1995 Aug 15;281(3):319-26
references.pmid: 8521916
references.citation: Neurobiol Aging. 2008 Dec;29(12):1894-901
references.pmid: 17561311
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4888-93
references.pmid: 19255436
references.citation: Anal Biochem. 1976 May 7;72:248-54
references.pmid: 942051
references.citation: Mol Pharmacol. 1995 Aug;48(2):352-61
references.pmid: 7651369
references.citation: Front Behav Neurosci. 2012 Mar 20;6:11
references.pmid: 22454620
references.citation: PLoS One. 2012;7(4):e35264
references.pmid: 22558133
references.citation: Psychopharmacology (Berl). 2015 Mar;232(5):931-42
references.pmid: 25189792
references.citation: Neuropharmacology. 2013 Oct;73:388-96
references.pmid: 23796670
references.citation: Behav Brain Res. 2015 May 1;284:24-36
references.pmid: 25660201
references.citation: Neurosci Lett. 2006 Apr 10-17;397(1-2):88-92
references.pmid: 16406322
references.citation: Clin Chim Acta. 1986 Mar 28;155(3):275-83
references.pmid: 3708856
references.citation: Neuroscience. 2009 Feb 18;158(4):1708-16
references.pmid: 19110037
references.citation: Brain. 2002 Oct;125(Pt 10):2152-90
references.pmid: 12244076
references.citation: Pharmacol Biochem Behav. 2005 Jun;81(2):331-42
references.pmid: 15927244
references.citation: Neuroscience. 2000;95(1):5-7
references.pmid: 10619457
references.citation: J Neurosci. 2009 Sep 9;29(36):11078-88
references.pmid: 19741114
references.citation: Nature. 1986 Jun 26-Jul 2;321(6073):864-6
references.pmid: 3724846
references.citation: Front Pharmacol. 2014 Mar 05;5:37
references.pmid: 24634659
references.citation: Neurobiol Learn Mem. 2008 Sep;90(2):374-81
references.pmid: 18524639
references.citation: Behav Brain Res. 2015 Sep 15;291:164-71
references.pmid: 25979787
references.citation: Int J Biochem Cell Biol. 2007;39(1):44-84
references.pmid: 16978905
references.citation: CNS Neurol Disord Drug Targets. 2009 Dec;8(6):403-21
references.pmid: 19839937