title: Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients.
abstract: Aging well has become the new target of preventative medicine, and aesthetic dermatology can contribute to this request. The polynucleotide (PN) containing products not only fill the space, but improve tissue regeneration, resulting in more natural tissue regeneration. Five Korean women received four times injections of long-chain PN filler in two-week intervals for skin rejuvenation. About 0.05 mL of material was injected in 40 points of one-side cheek. The pore and skin thickness were markedly improved in the patients in their 30s, whereas skin tone, melanin, wrinkles, and sagging were noticeably improved for patients in their 40s. There are no serious side effects. In conclusion, intradermal long-chain PN filler injection seems to be an effective and safe treatment for skin rejuvenation.
authors.affiliation: Departments of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Kui Young
authors.initials: KY
authors.lastname: Park
authors.affiliation: Departments of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Joon
authors.initials: J
authors.lastname: Seok
authors.affiliation: Leaders Aesthetic Laser and Cosmetic Surgery Center, Seoul, Korea.
authors.forename: Nark Kyoung
authors.initials: NK
authors.lastname: Rho
authors.affiliation: Departments of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Departments of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Myeung Nam
authors.initials: MN
authors.lastname: Kim
mesh_terms: D000328:Adult; D000367:Age Factors; D003357:Cosmetic Techniques; D000067548:Dermal Fillers / Q000008:administration & dosage* / Q000009:adverse effects; D004954:Esthetics; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D008875:Middle Aged; D017060:Patient Satisfaction; D011119:Polynucleotides / Q000008:administration & dosage* / Q000009:adverse effects; D012060:Rejuvenation; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D015595:Skin Aging; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000067548:Dermal Fillers; D011119:Polynucleotides
keywords: filler; polynucleotide; skin rejuvenation