title: High Expression of Intestinal Homing Receptor CD103 in Adult T-Cell Leukemia/Lymphoma, Similar to 2 Other CD8+ T-Cell Lymphomas.
abstract: We investigated the expression of the αEβ7 integrin (CD103)-intestinal homing receptor of T-intraepithelial lymphocytes (IELs) in 130 cases of adult T-cell leukemia/lymphoma (ATLL). We detected CD103 lymphoma cells in 55% (31/56) of mainly gastrointestinal (GI)-involved ATLL cases. Among them, lymphoma cells of 18 cases located in other involved organs had similar CD103 expression patterns. Histologically, we found (a) increased reactive IELs in non-neoplastic mucosal layers in 28% (5/18) of surgical and mucosal resection cases, (b) preserved epithelial glands, and (c) numerous small intraepithelial ATLL nests in involved lesions in 36 (69%) and 21 (40%), respectively, of the 52 examined cases. These 3 patterns were common in intestinal type II enteropathy-associated T-cell lymphoma but were rare in intestinal EBV nasal-type/like T/natural killer (NK)-cell lymphoma. We detected CD103 tumor cells in 41% (16/39) of lymph node-involved ATLL, in 31% (11/35) of skin-involved ATLL, in 68% (21/31) of type II CD4 enteropathy-associated T-cell lymphoma cases, in 36% (8/22) of primary gastric T/NK-cell lymphomas, and in 77% (7/9) of CD8 epidermotropic mycosis fungoides. CD103 ATLL prefers involving the GI tract over the skin (P<0.05). CD103 expression in GI-involved and/or total ATLL cases was significantly higher than in other 9 T/NK-cell lymphoma groups (P<0.05 or 0.01). Only ATLL cases were commonly CD103 in CD4 T/NK-cell lymphoma groups (P<0.05 or 0.01). Human T-lymphotropic virus-1-infected CD103 T-IELs and mucosal T cells may be important sources of ATLL.
authors.affiliation: Departments of *Internal Medicine †Pathology, Faculty of Medicine, Fukuoka University Departments of §Hematology ∥Pathology, Kyushu Medical Center, Fukuoka ‡Department of Internal Medicine, Division of Gastroenterology, School of Medicine, Iwate Medical, Morioka, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishitsuka
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Mihashi
authors.forename: Mikio
authors.initials: M
authors.lastname: Mizoguchi
authors.forename: Shotaro
authors.initials: S
authors.lastname: Nakamura
authors.forename: Seiichi
authors.initials: S
authors.lastname: Okamura
authors.forename: Seiya
authors.initials: S
authors.lastname: Momosaki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Aoyagi
authors.forename: Shotaro
authors.initials: S
authors.lastname: Sakisaka
authors.forename: Morishige
authors.initials: M
authors.lastname: Takeshita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000096:biosynthesis* / Q000276:immunology; D014408:Biomarkers, Tumor / Q000032:analysis; D058527:Enteropathy-Associated T-Cell Lymphoma / Q000473:pathology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D039001:Integrin alpha Chains / Q000096:biosynthesis* / Q000276:immunology; D053208:Kaplan-Meier Estimate; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D039001:Integrin alpha Chains; C091367:alpha E integrins