title: Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats.
abstract: OBJECTIVE
  to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study.
  
  
  METHODS
  thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, and mitosis of the liver stained with H&E.
  
  
  RESULTS
  the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups.
  
  
  CONCLUSIONS
  supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration.
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brasil.
authors.forename: Rosilda Mendes da
authors.initials: RM
authors.lastname: Silva
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brasil.
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Malafaia
authors.affiliation: Hospital São Domingos, São Luis, MA, Brasil.
authors.forename: Orlando Jorge Martins
authors.initials: OJ
authors.lastname: Torres
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brasil.
authors.forename: Nicolau Gregori
authors.initials: NG
authors.lastname: Czeczko
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brasil.
authors.forename: Carlos Hespanha
authors.initials: CH
authors.lastname: Marinho Junior
authors.affiliation: Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brasil.
authors.forename: Ronaldo Kiviatcoski
authors.initials: RK
authors.lastname: Kozlowski
mesh_terms: D000818:Animals; D004032:Diet; D015525:Fatty Acids, Omega-3; D006498:Hepatectomy; D008099:Liver; D008115:Liver Regeneration; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015525:Fatty Acids, Omega-3