title: Nonenzymatic enantioselective synthesis of all-carbon quaternary centers through desymmetrization.
abstract: The asymmetric desymmetrization ofmesoor prochiral compounds containing an all-carbon quaternary center is an attractive alternative to classical synthetic approaches aimed at the asymmetric formation of a new C-C bond. This review focuses on nonenzymatic desymmetrizations that utilize transition metal catalysts or organocatalysts to distinguish between enantiotopic groups to generate enantioenriched compounds containing all-carbon quaternary stereocenters.
authors.affiliation: Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
authors.forename: Kimberly S
authors.initials: KS
authors.lastname: Petersen
keywords: all-carbon quatemary center; asymmetric; desymmetrization; organocatalysis; transition-metal catalysis
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