title: Comparison of Clinicopathological Features and Prognosis in Triple-Negative and Non-Triple Negative Breast Cancer.
abstract: OBJECTIVE
  Triple-negative breast cancer (TNBC) has attracted more attention both clinically and experimentally because of its high-risk biological characteristics and lacking of effective treatment method. The purpose of this retrospective study was to find out the incidence of triple-negative breast cancer (TNBC) in all kinds of breast cancers and to compare and analyze the clinicopathological features, recurrence, metastasis and prognosis of patients with TNBC and non-triple negative breast cancer (non-TNBC).
  
  
  METHODS
  A total of 1578 female patients with primary breast cancer were diagnosed and treated at the department of General Surgery, the Chinese PLA General Hospital, China, from Jan. 2004 to Jun. 2009. The 1578 breast cancer patients were divided into two groups: the TNBC group and the non-TNBC group. The clinical features and prognosis of the two groups were compared.
  
  
  RESULTS
  The incidence of TNBC was 20.41%. Compared with the non-TNBC, the TNBC were characterized as younger age, higher histological grade, higher rate of positive lymph node, bigger tumor size, higher clinical stage at diagnosis, higher histological grade, quicker and easier recurrence and metastasis and lower 5-year DFS rate and 5-year OS rate. The metastasis of TNBC had obvious organic tendency. The lungs, liver and brain were the first three most common sites of metastases. The information of age, the tumor size, lymph node status, clinical stage, histological grade, pathological types and operation method, especially the age and lymph node status play the important roles in judging the prognosis of TNBC.
  
  
  CONCLUSIONS
  According to this study we found that TNBC was a distinct subgroup of breast cancer with particular clinicopathologic behavior. Compared with the non-TNBC, TNBC was characterized by more aggressive behavior, and lower DFS and OS rate. The metastasis of TNBC had obvious organic tendency. The information of age, the maximum diameter of the tumor, lymph node status, clinical stage, histological grade, pathological types and operation method, especially the age and lymph node status played the important roles in judging the prognosis of TNBC patients.
authors.affiliation: 1. Department of General Surgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Jingdan
authors.initials: J
authors.lastname: Qiu
authors.affiliation: 2. Department of Special Medical Treatment-Respiratory Disease, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Xinying
authors.initials: X
authors.lastname: Xue
authors.affiliation: 3. Department of Breast Surgery, Beijing Luhe Hospital, Capital Medical University Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Hu
authors.affiliation: 1. Department of General Surgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Xu
authors.affiliation: 1. Department of General Surgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Deqiang
authors.initials: D
authors.lastname: Kou
authors.affiliation: 1. Department of General Surgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.affiliation: 3. Department of Breast Surgery, Beijing Luhe Hospital, Capital Medical University Beijing, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
keywords: Triple-negative breast cancer
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