title: Gankyrin regulates cell signaling network.
abstract: Gankyrin is an oncoprotein that facilitates the degradation of two key tumor suppressors, namely, Rb and p53. Although Gankyrin overexpression was identified in different carcinomas eventually and associated with poor prognosis, its function and mechanism remain not well understood. Recently, the signal transduction mechanisms of Gankyrin have been explored, which may provide new drug targets in tumors overexpressing Gankyrin. In this review, we summarize the significant signal transduction pathways regulated by Gankyrin.
authors.affiliation: Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 280 Mohe Road, Shanghai, 201900, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 280 Mohe Road, Shanghai, 201900, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 280 Mohe Road, Shanghai, 201900, China. zhangyanjie@shsmu.edu.cn.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D002471:Cell Transformation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; C403591:PSMD10 protein, human; D011518:Proto-Oncogene Proteins; D046988:Proteasome Endopeptidase Complex
keywords: Biomarker; Cancer; Cell signaling pathway; Drug target; Gankyrin
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