title: Health-related quality of life questionnaire for polycystic ovary syndrome (PCOSQ-50): development and psychometric properties.
abstract: The determinants of the health-related quality of life of women with polycystic ovary syndrome are not fully understood. The aim of this study was to develop a comprehensive instrument to assess the health-related quality of life of Iranian women with PCOS and to assess its psychometric properties.
  
  
  
  We used a mixed-method, sequential, exploratory design including both qualitative [in-depth interview to define the components of health-related quality of life questionnaire (PCOSQ)] and quantitative approaches (to assess the psychometric properties of PCOSQ).
  
  
  
  A preliminary questionnaire was developed including 147 items which emerged from the qualitative phase of the study. Considering the optimum cutoff points for content validity ratio (CVR), content validity index (CVI), and impact score, items of the preliminary questionnaire were reduced from 147 to 88 items. Finally, by excluding highly correlated items using the exploratory factor analysis, a 50-item questionnaire was obtained. The Kaiser criteria (eigenvalues >1) and Scree plot tests demonstrated that six factors were optimum with an estimated 47.3 % of variance. Assessment of the psychometric properties of the questionnaire demonstrated a mean CVI = 0.92, CVR = 0.91, Cronbach's alpha for whole questionnaire = 0.88 (0.61-0.88 for subscales), Spearman's correlation coefficients of test-retest = 0.75, and the intra-class correlation coefficient for the PCOS questionnaire subscales ranging from 0.57 to 0.88. Eventually the final questionnaire included 50 items in six domains, 'psychosocial and emotional,' 'fertility,' 'sexual function,' 'obesity and menstrual disorders,' 'hirsutism,' and 'coping' and rated on a 5-point Likert scale.
  
  
  
  The PCOSQ-50 is a valid and reliable instrument for the assessment of quality of life of women with PCOS, capable of assessing some obscure aspects overlooked by previous HRQL questionnaires.
authors.affiliation: Department of Midwifery, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Nasiri-Amiri
authors.affiliation: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 24 Parvaneh, Yaman Street, Velenjak, P.O. Box 19395-4763, Tehran, 1985717413, Iran. ramezani@endocrine.ac.ir.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Ramezani Tehrani
authors.affiliation: Department of Midwifery and Reproductive Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Simbar
authors.affiliation: Mental Health Research Group, Health Metrics Research Centre, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Montazeri
authors.affiliation: Department of Biostatistics, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Reza Ali
authors.initials: RA
authors.lastname: Mohammadpour
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004644:Emotions; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications; D007492:Iran; D008599:Menstruation Disturbances / Q000150:complications; D009765:Obesity / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000473:pathology / Q000523:psychology*; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires
keywords: Content analysis; Development; Polycystic ovary syndrome; Psychometric; Quality of life
references.citation: Hum Reprod. 2004 Feb;19(2):371-7
references.pmid: 14747184
references.citation: Int J Impot Res. 2007 Jul-Aug;19(4):353-7
references.pmid: 17287832
references.citation: Ann Intern Med. 1993 Apr 15;118(8):622-9
references.pmid: 8452328
references.citation: J Obstet Gynecol Neonatal Nurs. 2006 May-Jun;35(3):385-92
references.pmid: 16700688
references.citation: Acta Derm Venereol. 2012 Jan;92(1):40-4
references.pmid: 21710106
references.citation: Fertil Steril. 1988 Feb;49(2):258-62
references.pmid: 3338582
references.citation: Clin Endocrinol (Oxf). 2007 Mar;66(3):373-9
references.pmid: 17302871
references.citation: J Sex Med. 2012 Jan;9(1):224-30
references.pmid: 22082203
references.citation: Fertil Steril. 2012 Jan;97(1):28-38.e25
references.pmid: 22153789
references.citation: Br J Dermatol. 1999 Apr;140(4):672-6
references.pmid: 10233319
references.citation: Obesity (Silver Spring). 2009 May;17(5):1070-6
references.pmid: 19180069
references.citation: J Clin Endocrinol Metab. 1999 Jun;84(6):1897-9
references.pmid: 10372683
references.citation: J Clin Endocrinol Metab. 1998 Jun;83(6):1976-87
references.pmid: 9626128
references.citation: Hum Reprod Update. 2008 Jan-Feb;14(1):15-25
references.pmid: 17905857
references.citation: Hum Reprod Update. 2014 May-Jun;20(3):334-52
references.pmid: 24345633
references.citation: Nurs Res. 2006 Mar-Apr;55(2):75-81
references.pmid: 16601619
references.citation: J Psychosom Res. 1993 Sep;37(6):615-9
references.pmid: 8410747
references.citation: Gynecol Endocrinol. 2006 Feb;22(2):80-6
references.pmid: 16603432
references.citation: Hum Reprod. 2007 Aug;22(8):2279-86
references.pmid: 17537782
references.citation: J Sex Med. 2014 Oct;11(10):2508-14
references.pmid: 24995944
references.citation: Endocrinol Metab Clin North Am. 1999 Jun;28(2):247-63
references.pmid: 10352918
references.citation: Eur Respir J. 2002 Mar;19(3):499-503
references.pmid: 11936529
references.citation: Qual Life Res. 2005 Apr;14(3):875-82
references.pmid: 16022079
references.citation: J Clin Epidemiol. 2004 Dec;57(12):1279-87
references.pmid: 15617954
references.citation: Soc Sci Med. 2002 Feb;54(3):349-61
references.pmid: 11824912
references.citation: J Obstet Gynecol Neonatal Nurs. 2005 Jan-Feb;34(1):12-20
references.pmid: 15673641
references.citation: J Clin Endocrinol Metab. 2004 Jun;89(6):2745-9
references.pmid: 15181052
references.citation: J Clin Endocrinol Metab. 2003 Dec;88(12):5801-7
references.pmid: 14671172
references.citation: N Engl J Med. 1996 Mar 28;334(13):835-40
references.pmid: 8596551
references.citation: Int J Nurs Stud. 2003 Aug;40(6):619-25
references.pmid: 12834927
references.citation: Drug Healthc Patient Saf. 2009;1:9-15
references.pmid: 21701605
references.citation: Nurs Res. 2001 Sep-Oct;50(5):300-4
references.pmid: 11570715
references.citation: Compr Psychiatry. 2011 Sep-Oct;52(5):486-9
references.pmid: 21193185
references.citation: BMJ. 1997 Feb 22;314(7080):572
references.pmid: 9055718
references.citation: Iran Red Crescent Med J. 2014 Feb;16(2):e12423
references.pmid: 24719724
references.citation: Folia Histochem Cytobiol. 2007;45 Suppl 1:S93-7
references.pmid: 18292843
references.citation: Reprod Biol Endocrinol. 2011 Nov 01;9:144
references.pmid: 22044512
references.citation: Postgrad Med J. 1993 Mar;69(809):186-9
references.pmid: 8497431
references.citation: Nurs Res. 1992 May-Jun;41(3):186-8
references.pmid: 1584664
references.citation: Biometrics. 1977 Mar;33(1):159-74
references.pmid: 843571
references.citation: J Endocrinol Invest. 2015 Aug;38(8):923-8
references.pmid: 25740069
references.citation: Value Health. 2010 Jun-Jul;13(4):440-6
references.pmid: 20230548
references.citation: Obes Res. 2001 Aug;9(8):478-85
references.pmid: 11500528
references.citation: PLoS One. 2015 Apr 15;10(4):e0123608
references.pmid: 25874409
references.citation: Value Health. 2004 Sep-Oct;7 Suppl 1:S13-6
references.pmid: 15367238
references.citation: Fertil Steril. 1989 Sep;52(3):425-32
references.pmid: 2776896
references.citation: Reprod Biol Endocrinol. 2011 Mar 25;9:39
references.pmid: 21435276