title: A Competent and Commercially Viable Process for the Synthesis of the Anti-Hypertensive Drug Olmesartan Medoxomil.
abstract: Drug product purity and potency are of most significance in the regulatory market as we notice many recalled batches worldwide, particularly in the US and Japan. Olmesartan Medoxomil is an anti-hypertensive drug. The present invention relates to a process for the preparation of Olmesartan Medoxomil with 99.9% purity in an overall 62% yield. The synthesis includes three isolations and one purification with easy plant operations. This process describes the formation and control of each individual impurity in all stages. This process for Olmesartan Medoxomil and its intermediates is competent for industrial production in very short reaction time intervals with an appreciable yield and high purity.
authors.affiliation: Chemical Research and Development, Aurobindo Pharma Pvt Ltd, Survey No. 71& 72, Indrakaran Village, Sangareddy Mandal, Medak District, Telangana-502329, India; Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur District, Andhra Pradesh-522510, India.
authors.forename: Bommena
authors.initials: B
authors.lastname: Hanumantha Rao
authors.affiliation: Chemical Research and Development, Aurobindo Pharma Pvt Ltd, Survey No. 71& 72, Indrakaran Village, Sangareddy Mandal, Medak District, Telangana-502329, India.
authors.forename: Inti Venkata
authors.initials: IV
authors.lastname: Subramanyeswara Rao
authors.affiliation: Chemical Research and Development, Aurobindo Pharma Pvt Ltd, Survey No. 71& 72, Indrakaran Village, Sangareddy Mandal, Medak District, Telangana-502329, India.
authors.forename: Vysyaraju
authors.initials: V
authors.lastname: Ravi Kanth
authors.affiliation: Chemical Research and Development, Aurobindo Pharma Pvt Ltd, Survey No. 71& 72, Indrakaran Village, Sangareddy Mandal, Medak District, Telangana-502329, India.
authors.forename: Korrapati Venkata Vara
authors.initials: KV
authors.lastname: Prasada Rao
authors.affiliation: Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur District, Andhra Pradesh-522510, India.
authors.forename: K
authors.initials: K
authors.lastname: Balamurali Krishna
authors.affiliation: Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur District, Andhra Pradesh-522510, India.
authors.forename: Bethanabatla
authors.initials: B
authors.lastname: Syama Sundar
keywords: Anti-hypertensive Drug; Impurities; Olmesartan medoxomil; Process Development; Synthesis
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