title: Adult pertussis is unrecognized public health problem in Thailand.
abstract: BACKGROUND
  Although pertussis has been considered a disease of childhood, it is also recognized as an important respiratory tract infection in adolescents and adults. However, in countries with routine vaccination against pertussis with high coverage, pertussis is not usually taken into consideration for the etiology of prolonged cough in adults. Previous studies in a variety of populations in developed countries have documented that pertussis is quite common, ranging from 2.9 to 32% of adolescents and adults with prolonged cough. The anticipation and early recognition of this change in the epidemiology is important because the affected adolescents and adults act as reservoirs of the disease and source of infection to the vulnerable population of infants, for whom the disease can be life threatening. We conducted a prospective study to determine the prevalence of pertussis in Thai adults with prolonged cough.
  
  
  METHODS
  Seventy-six adult patients with a cough lasting for more than 2 weeks (range, 14-180 days) were included in the present study. The data regarding medical history and physical examination were carefully analyzed. Nasopharyngeal swabs from all patients were obtained for the detection of deoxyribonucleic acid of Bordetella pertussis by the polymerase chain reaction (PCR) method. Paired serum samples were collected and tested for IgG antibody against pertussis toxin by using an ELISA method.
  
  
  RESULTS
  Of 76 adult patients, 14 patients (18.4%) with the mean age of 59 (range, 28-85) years and the mean duration of cough of 34 (range, 14-120) days had laboratory evidence of acute pertussis infection. One patient was diagnosed by the PCR method, while the rest had serological diagnosis. Whooping cough is a significantly associated symptom of patients with chronic cough who had laboratory evidence of pertussis. (p < .05, odds ratio 3.75, 95% confidence interval: 1.00, 14.06) CONCLUSION: Pertussis is being increasingly recognized as a cause of prolonged, distressing cough among adults in Thailand. This result addresses the need of pertussis vaccination in Thai adults for preventing transmission to a high risk group such as newborn infants.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Bangkok, 10330, Thailand. niradasiriyakorn@hotmail.com.|Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima, Thailand. niradasiriyakorn@hotmail.com.
authors.forename: Nirada
authors.initials: N
authors.lastname: Siriyakorn
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Bangkok, 10330, Thailand. pop15495@gmail.com.|Department of Medicine, Samutprakarn Hospital, Samutprakarn, Thailand. pop15495@gmail.com.
authors.forename: Pornvimol
authors.initials: P
authors.lastname: Leethong
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Bangkok, 10330, Thailand. terapong_tantawichien@hotmail.com.
authors.forename: Terapong
authors.initials: T
authors.lastname: Tantawichien
authors.affiliation: National Institute of Health, Ministry of Public Health, Bangkok, Thailand. lek_lex40@hotmail.com.
authors.forename: Saowalak
authors.initials: S
authors.lastname: Sripakdee
authors.affiliation: National Institute of Health, Ministry of Public Health, Bangkok, Thailand. noksak99@gmail.com.|Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon, Thailand. noksak99@gmail.com.
authors.forename: Anusak
authors.initials: A
authors.lastname: Kerdsin
authors.affiliation: National Institute of Health, Ministry of Public Health, Bangkok, Thailand. surang_dej@yahoo.com.
authors.forename: Surang
authors.initials: S
authors.lastname: Dejsirilert
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Bangkok, 10330, Thailand. leilani.p@chula.ac.th.|Division of Infectious Diseases, Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. leilani.p@chula.ac.th.
authors.forename: Leilani
authors.initials: L
authors.lastname: Paitoonpong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001886:Bordetella pertussis / Q000235:genetics; D003371:Cough / Q000209:etiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D037342:Pertussis Toxin / Q000276:immunology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011446:Prospective Studies; D011634:Public Health; D012141:Respiratory Tract Infections / Q000150:complications; D013785:Thailand; D014917:Whooping Cough / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D037342:Pertussis Toxin
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