title: The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity.
abstract: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive cortisone to active cortisol, has been reported to play an important role in metabolic diseases as well as chronic inflammatory diseases. The involvement of 11β-HSD1 in chronic periodontitis was investigated in the present study. The relationship between the levels of 11β-HSD1, chronic periodontitis, and body mass index (BMI) was analyzed. The expression of 11β-HSD1 mRNA was significantly higher in the chronic periodontitis group than in the control group. Since the expression of 11β-HSD2, which converts active cortisol to inactive cortisone, was slightly lower in the chronic periodontitis group than in the controls, the ratio of 11β-HSD1 versus 11β-HSD2 was significantly higher in the chronic periodontitis group than in the controls. A correlation was not observed between BMI and the level of 11β-HSD1 or between BMI and the ratio of 11β-HSD1 versus 11β-HSD2. These results suggested that an increase in the ratio of 11β-HSD1 versus 11β-HSD2 was associated with chronic periodontitis irrespective of obesity.
authors.affiliation: Department of Periodontology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121 Japan.
authors.forename: Takaya
authors.initials: T
authors.lastname: Nakata
authors.affiliation: Department of Periodontology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121 Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Fujita
authors.affiliation: Department of Periodontology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121 Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Umeda
authors.affiliation: First Department of Oral and Maxillofacial Surgery, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121 Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yoshida
authors.affiliation: Department of Orthodontics, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121 Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Inami
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, 1 Senbaru, Nishiharacho, Nakagamigun, Okinawa 903-0213 Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Masuzaki
authors.affiliation: Department of Internal Medicine, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121 Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sawai
keywords: 11β-Hydroxysteroid dehydrogenase type 1; 11β-Hydroxysteroid dehydrogenase type 2; Chronic periodontitis; Cortisol; Obesity
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