title: Hepatitis E in Transplantation.
abstract: Hepatitis E virus (HEV) has a worldwide distribution and is known to cause acute and fulminant hepatitis. However, over the last few years, it has been shown to also cause chronic hepatitis and cirrhosis in immunosuppressed patients, especially solid-organ-transplant patients. In immunocompetent and immunosuppressed patients, HEV is also associated with extra-hepatic manifestations, such as neurological symptoms and kidney injury. Unfortunately, a diagnostic assay for HEV infection is still not available in all countries. Reduction of immunosuppression is the first-line therapeutic option for organ-transplant patients with chronic hepatitis. In addition, ribavirin is highly efficient at treating chronic HEV infection. In this comprehensive review, we summarize the current knowledge regarding HEV diagnosis, its natural history, clinical manifestations, and treatments in patients with a solid-organ transplant.
authors.affiliation: Department of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059, Toulouse Cedex 9, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Marion
authors.affiliation: INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France.|Université Paul Sabatier, Toulouse, France.|Laboratory of Virology, CHU Purpan, Toulouse, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Abravanel
authors.affiliation: INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France.|Université Paul Sabatier, Toulouse, France.|Laboratory of Virology, CHU Purpan, Toulouse, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Lhomme
authors.affiliation: INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France.|Université Paul Sabatier, Toulouse, France.|Laboratory of Virology, CHU Purpan, Toulouse, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
authors.affiliation: Department of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059, Toulouse Cedex 9, France. kamar.n@chu-toulouse.fr.|INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France. kamar.n@chu-toulouse.fr.|Université Paul Sabatier, Toulouse, France. kamar.n@chu-toulouse.fr.
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
keywords: Chronic hepatitis; Extra-hepatic manifestations; Hepatitis E virus; Ribavirin; Transplantation
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