title: Mallotojaponins B and C: Total Synthesis, Antiparasitic Evaluation, and Preliminary SAR Studies.
abstract: The first total syntheses of mallotojaponin B and C as well as several analogues have been achieved. Biological evaluation of the synthesized compounds against Plasmodium falciparum and Trypanosoma brucei have also been carried out.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud , Univ. Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Tatyana D
authors.initials: TD
authors.lastname: Grayfer
authors.affiliation: UMR 7245 CNRS, Département RDDM, Muséum National d'Histoire Naturelle CP52 , 57 Rue Cuvier, 75005 Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Grellier
authors.affiliation: UMR 7245 CNRS, Département RDDM, Muséum National d'Histoire Naturelle CP52 , 57 Rue Cuvier, 75005 Paris, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Mouray
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud , Univ. Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Dodd
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud , Univ. Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Joëlle
authors.initials: J
authors.lastname: Dubois
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud , Univ. Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Kevin
authors.initials: K
authors.lastname: Cariou
mesh_terms: D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010696:Phloroglucinol / Q000031:analogs & derivatives; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents; D014346:Trypanosoma brucei brucei / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D014344:Trypanocidal Agents; C581272:mallotojaponin B; C581271:mallotojaponin C; D010696:Phloroglucinol