title: Design and Synthesis of Core-Shell-Shell Upconversion Nanoparticles for NIR-Induced Drug Release, Photodynamic Therapy, and Cell Imaging.
abstract: Novel core-shell-shell structured nanoparticles 75 nm in diameter with all-in-one "smart" functional capabilities for simultaneous photoresponsive drug release, photodynamic therapy, and cell imaging are designed and prepared. These nanoparticles consist of an upconversion (UC) emission core, a photosensitizer-embodied silica sandwich shell, and a β-cyclodextrin (β-CD) gated mesoporous silica outmost shell with drugs (Rhodamine B as a model) loaded inside. We show in this proof-of-concept demonstration that, under 980 nm near-infrared irradiation, UC 540 nm green light emissions were emitted for cell imaging, and 660 nm red light emissions were excited for activating photosensitizers to generate singlet oxygen, which could be exploited directly to kill cancer cells and simultaneously dissociate β-CD gatekeeper to release drugs. The preliminary results reported here will shed new light on the future design and applications of multifunctional platforms for cancer therapy and diagnostic.
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology , Harbin 150001, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology , Harbin 150001, China.
authors.forename: Ren-lu
authors.initials: RL
authors.lastname: Han
authors.affiliation: Department of Pathophysiology, Harbin Medical University , Harbin 150081, China.
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Yang
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology , Harbin 150001, China.
authors.forename: Jun-hui
authors.initials: JH
authors.lastname: Shi
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology , Harbin 150001, China.|School of Chemical Engineering and Technology, Harbin Institute of Technology , Harbin 150001, China.
authors.forename: Zong-jun
authors.initials: ZJ
authors.lastname: Liu
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology , Harbin 150001, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology , Harbin 150001, China.
authors.forename: You
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology , Harbin 150001, China.
authors.forename: Shu-juan
authors.initials: SJ
authors.lastname: Liu
authors.affiliation: School of Chemical Engineering and Technology, Harbin Institute of Technology , Harbin 150001, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gan
mesh_terms: D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D057054:Molecular Imaging / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods; D012235:Rhodamines / Q000737:chemistry* / Q000627:therapeutic use; D026082:Singlet Oxygen / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D012235:Rhodamines; D047392:beta-Cyclodextrins; D026082:Singlet Oxygen; C031215:betadex; C029773:rhodamine B
keywords: cell imaging; drug delivery; near-infrared light; photodynamic therapy; upconversion nanoparticles