title: Hemoglobin as a possible biochemical index of hypertension-induced vascular damage.
abstract: BACKGROUND
  We previously reported on the positive association of hemoglobin with hypertension and atherosclerosis. On the other hand, hepatocyte growth factor (HGF) has been evaluated as a possible biochemical index of hypertension-induced vascular damage. However, no studies have reported on a correlation between hemoglobin and HGF accounting for hypertension status.
  
  
  METHODS
  A cross-sectional study of 1108 subjects (392 men and 716 women, 40-93 years old) who were undergoing a general checkup in 2014 was conducted.
  
  
  RESULTS
  Multiple linear regression analysis adjustment for known cardiovascular risk factors showed no significant correlation between hemoglobin and HGF in non-hypertensive subjects, but a significant positive correlation in hypertensive subjects; β (parameter estimate) = 0.3 (p = 0.975) for non-hypertensive men, β = 0.4 (p = 0.925) for non-hypertensive women, β = 32.7 (p < 0.001) for hypertensive men, and β = 18.7 (p = 0.002) for hypertensive women.
  
  
  CONCLUSIONS
  We found a significant positive correlation between hemoglobin and HGF among hypertensive men and women. Like HGF, hemoglobin may be a useful indicator to evaluate hypertension-induced vascular damage. Since hemoglobin can easily be measured, these results support hemoglobin as an efficient tool to evaluate vascular damage induced by hypertension in daily medical practice.
authors.affiliation: Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan. simizicyuu@yahoo.co.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimizu
authors.affiliation: Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kadota
authors.affiliation: Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Mio
authors.initials: M
authors.lastname: Nakazato
authors.affiliation: Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Noguchi
authors.affiliation: Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Koyamatsu
authors.affiliation: Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Yamanashi
authors.affiliation: Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Mako
authors.initials: M
authors.lastname: Nagayoshi
authors.affiliation: Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Nagata
authors.affiliation: Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Arima
authors.affiliation: Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006454:Hemoglobins / Q000032:analysis*; D017228:Hepatocyte Growth Factor / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; C066855:HGF protein, human; D006454:Hemoglobins; D017228:Hepatocyte Growth Factor
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