title: MicroRNA-96 promotes myocardial hypertrophy by targeting mTOR.
abstract: As a main cause of cardiac hypertrophy, myocardial hypertrophy includes the proliferation and enlongation of myocardial cell, resulting in abnormally cardiac enlargement. However, the pathogenesis and the molecular mechanism that regulate gene expression of myocardial hypertrophy remain incompletely understood. MiRNAs were deemed as an important molecules involved in a variety of pathological processes. MiR-96 has been reported being associated with the tumor proliferation, but whether miR-96 is involved in cardiac hypertrophy remains uncertain. In this study, we have confirmed that, as the myocardial hypertrophy gene, mTOR was a target gene of miR-96, who would promote the occurrence of myocardial hypertrophy. Thus, we got the conclusion that miR-96 could promote myocardial hypertrophy by inhibiting mTOR, miR-96 and mTOR were negatively correlated.
authors.affiliation: The Fourth Department of Cardiology, Tangshan Worker Hospital Tangshan 063300, Hebei, P. R. China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Sun
authors.affiliation: The Fourth Department of Cardiology, Tangshan Worker Hospital Tangshan 063300, Hebei, P. R. China.
authors.forename: Chunlai
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000201:enzymology* / Q000473:pathology; D034622:RNA Interference; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D014162:Transfection
chemical_list: C000591374:MIRN96 microRNA, rat; D035683:MicroRNAs; C546845:mTOR protein, rat; D058570:TOR Serine-Threonine Kinases
keywords: MiR-96; mTOR; myocardial hypertrophy; target gene
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