title: In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders.
abstract: Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer's disease, and epilepsy point to the involvement of ECM molecules such as chondroitin sulfate proteoglycans, Reelin, and matrix metalloproteases, as well as their cell surface receptors. In many of these disorders, PNN abnormalities have also been reported. In the context of the "quadripartite" synapse concept, that is, the functional unit composed of the pre- and postsynaptic terminals, glial processes, and ECM, and of the role that PNNs and ECM molecules play in regulating synaptic functions and plasticity, these findings resonate with one of the most well-replicated aspects of the pathology of psychiatric disorders, that is, synaptic abnormalities. Here we review the evidence for PNN/ECM-related pathology in these disorders, with particular emphasis on schizophrenia, and discuss the hypothesis that such pathology may significantly contribute to synaptic dysfunction.
authors.affiliation: Translational Neuroscience Laboratory, Mclean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Harry
authors.initials: H
authors.lastname: Pantazopoulos
authors.affiliation: Translational Neuroscience Laboratory, Mclean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Sabina
authors.initials: S
authors.lastname: Berretta
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology*; D009415:Nerve Net / Q000503:physiopathology*; D009473:Neuronal Plasticity / Q000502:physiology*; D000091042:Reelin Protein; D013569:Synapses / Q000502:physiology*
references.citation: Neurosci Lett. 2015 May 6;594:122-6
references.pmid: 25817362
references.citation: Neurobiol Dis. 2009 Aug;35(2):219-33
references.pmid: 19442733
references.citation: Prog Neurobiol. 2005 Dec;77(5):283-98
references.pmid: 16352388
references.citation: Biol Psychiatry. 2015 Dec 1;78(11):775-85
references.pmid: 25981171
references.citation: Neuron. 2000 Jul;27(1):33-44
references.pmid: 10939329
references.citation: J Psychiatr Res. 2011 Jan;45(1):47-53
references.pmid: 20684831
references.citation: Ann Neurol. 1991 Oct;30(4):572-80
references.pmid: 1789684
references.citation: Brain Res Mol Brain Res. 1999 Sep 8;72(1):47-54
references.pmid: 10521598
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2014 Mar;165B(2):192-200
references.pmid: 24453138
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3123-7
references.pmid: 18287055
references.citation: J Neurol Sci. 2008 Mar 15;266(1-2):126-30
references.pmid: 17928006
references.citation: Neuroreport. 1995 Mar 27;6(5):733-6
references.pmid: 7605936
references.citation: J Neurosci. 2004 Oct 20;24(42):9244-9
references.pmid: 15496659
references.citation: J Chem Neuroanat. 2001 Jul;22(1-2):95-100
references.pmid: 11470557
references.citation: Neurosci Biobehav Rev. 2014 Sep;45:85-99
references.pmid: 24709070
references.citation: Epilepsia. 2015 Jul;56(7):1124-33
references.pmid: 26032766
references.citation: Brain Res Bull. 2012 Sep 1;88(6):543-52
references.pmid: 22688012
references.citation: Front Neuroanat. 2014 Sep 10;8:97
references.pmid: 25309341
references.citation: Neuroscience. 2010 Sep 1;169(3):1347-63
references.pmid: 20497908
references.citation: Curr Opin Pharmacol. 2015 Feb;20:109-15
references.pmid: 25540902
references.citation: J Neurosci. 2012 Sep 12;32(37):12854-61
references.pmid: 22973009
references.citation: Mol Psychiatry. 2002;7(9):919-20
references.pmid: 12399938
references.citation: Biol Psychiatry. 2004 Mar 1;55(5):464-71
references.pmid: 15023573
references.citation: J Neurosci. 2014 Jul 23;34(30):9867-79
references.pmid: 25057190
references.citation: Prog Brain Res. 2015;218:213-26
references.pmid: 25890139
references.citation: Trends Neurosci. 2010 Nov;33(11):503-12
references.pmid: 20832873
references.citation: J Neurochem. 2014 Sep;130(6):797-804
references.pmid: 24903590
references.citation: Neuroscientist. 2002 Jun;8(3):221-33
references.pmid: 12061502
references.citation: Biol Psychiatry. 2001 Oct 1;50(7):521-30
references.pmid: 11600105
references.citation: J Neurosci. 1996 Dec 15;16(24):7910-9
references.pmid: 8987819
references.citation: Mol Cell Neurosci. 2013 Nov;57:10-22
references.pmid: 23999154
references.citation: Am J Med Genet. 1986 Jan-Feb;23(1-2):403-8
references.pmid: 3953658
references.citation: Cereb Cortex. 1995 Nov-Dec;5(6):550-60
references.pmid: 8590827
references.citation: Schizophr Res. 2015 May;164(1-3):100-8
references.pmid: 25757715
references.citation: Schizophr Bull. 2012 Sep;38(5):920-6
references.pmid: 22987850
references.citation: J Neurosci. 2005 Sep 7;25(36):8209-16
references.pmid: 16148228
references.citation: Mol Psychiatry. 2008 Feb;13(2):147-61
references.pmid: 17471287
references.citation: Mol Psychiatry. 2003 Sep;8(9):769, 821-31
references.pmid: 12931209
references.citation: Nat Genet. 2013 Oct;45(10):1150-9
references.pmid: 23974872
references.citation: Proc Natl Acad Sci U S A. 2006 May 30;103(22):8517-22
references.pmid: 16709670
references.citation: JAMA Psychiatry. 2014 Dec 1;71(12):1323-31
references.pmid: 25271938
references.citation: Brain Res Rev. 2006 Sep;52(2):293-304
references.pmid: 16759710
references.citation: Schizophr Res. 2011 Apr;127(1-3):28-34
references.pmid: 21239144
references.citation: Acta Neuropathol. 1997 Jan;93(1):50-61
references.pmid: 9006657
references.citation: Schizophr Bull. 2015 Jul;41(4):835-46
references.pmid: 26032508
references.citation: Schizophr Bull. 2012 Sep;38(5):950-7
references.pmid: 22355184
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2008 Mar 5;147B(2):194-200
references.pmid: 17955477
references.citation: J Neurosci. 2005 Feb 2;25(5):1081-8
references.pmid: 15689543
references.citation: Brain Res. 1994 Sep 26;658(1-2):67-86
references.pmid: 7834357
references.citation: J Neurosci. 2006 Oct 25;26(43):10939-48
references.pmid: 17065436
references.citation: Semin Cell Dev Biol. 2012 Feb;23(1):75-82
references.pmid: 22040917
references.citation: Histochem Cell Biol. 2008 Oct;130(4):635-53
references.pmid: 18696101
references.citation: Prog Brain Res. 2014;214:263-84
references.pmid: 25410362
references.citation: J Biol Chem. 2007 Jun 1;282(22):16036-41
references.pmid: 17426029
references.citation: Neuroreport. 2007 Jan 8;18(1):57-60
references.pmid: 17259861
references.citation: Biol Psychiatry. 2002 Nov 1;52(9):874-9
references.pmid: 12399140
references.citation: Neurobiol Dis. 2014 Oct;70:21-31
references.pmid: 24946277
references.citation: Neurology. 1985 Jun;35(6):866-74
references.pmid: 4000488
references.citation: Crit Rev Neurobiol. 1998;12(1-2):21-36
references.pmid: 9444480
references.citation: Nat Rev Neurosci. 2014 May;15(5):300-12
references.pmid: 24713688
references.citation: Neuron. 2012 Sep 20;75(6):951-62
references.pmid: 22998865
references.citation: J Neurosci. 2011 Oct 5;31(40):14413-23
references.pmid: 21976526
references.citation: Biol Psychiatry. 2015 Jun 1;77(11):959-68
references.pmid: 25433904
references.citation: Neuroscience. 2010 Nov 10;170(4):1314-27
references.pmid: 20732394
references.citation: Neuroscience. 1994 Jan;58(2):371-88
references.pmid: 7512240
references.citation: Acta Neuropathol. 2013 Feb;125(2):215-29
references.pmid: 22961619
references.citation: Behav Brain Res. 2012 Mar 17;228(2):247-53
references.pmid: 22101175
references.citation: Brain Res Mol Brain Res. 1996 Aug;40(1):79-96
references.pmid: 8840016
references.citation: Science. 2002 Jul 19;297(5580):353-6
references.pmid: 12130773
references.citation: Exp Neurol. 2003 Dec;184(2):705-14
references.pmid: 14769362
references.citation: Neurobiol Dis. 2010 Mar;37(3):738-46
references.pmid: 20034564
references.citation: Schizophr Res. 2010 May;118(1-3):303-4
references.pmid: 20153953
references.citation: Psychopharmacology (Berl). 2005 Jul;180(2):191-205
references.pmid: 15864560
references.citation: Neuroscience. 2007 Nov 30;150(1):31-9
references.pmid: 17928157
references.citation: Neuroscience. 2012 Aug 30;218:367-84
references.pmid: 22659016
references.citation: Crit Rev Neurobiol. 2004;16(1-2):1-23
references.pmid: 15581395
references.citation: Neurochem Res. 2000 Oct;25(9-10):1207-18
references.pmid: 11059795
references.citation: Nature. 2014 Jul 24;511(7510):421-7
references.pmid: 25056061
references.citation: Mol Psychiatry. 2001 Mar;6(2):150-9
references.pmid: 11317216
references.citation: J Neurosci Res. 2005 May 15;80(4):539-48
references.pmid: 15806566
references.citation: Mol Psychiatry. 2006 May;11(5):471-8
references.pmid: 16402134
references.citation: Neuropsychopharmacology. 2009 Jan;34(2):374-89
references.pmid: 18463626
references.citation: Neuron. 2001 Sep 27;31(6):1001-13
references.pmid: 11580899
references.citation: Mol Psychiatry. 2002;7(9):1012-7
references.pmid: 12399956
references.citation: Int J Neurosci. 2007 Jan;117(1):25-46
references.pmid: 17365098
references.citation: Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5052-6
references.pmid: 22411800
references.citation: Genes Brain Behav. 2010 Feb;9(1):11-25
references.pmid: 19751394
references.citation: Semin Thromb Hemost. 2013 Nov;39(8):950-4
references.pmid: 24108470
references.citation: Science. 2008 Apr 11;320(5873):201-5
references.pmid: 18403705
references.citation: Dialogues Clin Neurosci. 2014 Mar;16(1):11-27
references.pmid: 24733968
references.citation: Neuron. 2004 Dec 2;44(5):749-57
references.pmid: 15572107
references.citation: J Cell Biol. 2008 Mar 10;180(5):1021-35
references.pmid: 18332222
references.citation: Cell Tissue Res. 2001 Oct;306(1):15-26
references.pmid: 11683176
references.citation: Neurodegeneration. 1996 Dec;5(4):445-51
references.pmid: 9117561
references.citation: Int Rev Neurobiol. 2005;71:179-87
references.pmid: 16512351
references.citation: Neuron. 2007 Jul 5;55(1):87-102
references.pmid: 17610819
references.citation: Eur J Neurosci. 2000 Oct;12(10):3721-8
references.pmid: 11029642
references.citation: J Cell Biol. 2003 Oct 13;163(1):97-107
references.pmid: 14530380
references.citation: Neuromolecular Med. 2012 Mar;14(1):53-64
references.pmid: 22322903
references.citation: Nat Rev Neurosci. 2006 Nov;7(11):850-9
references.pmid: 17053810
references.citation: Physiol Rev. 2000 Oct;80(4):1267-90
references.pmid: 11015614
references.citation: Neuron. 2005 Aug 18;47(4):567-79
references.pmid: 16102539
references.citation: Nat Neurosci. 2010 Nov;13(11):1388-95
references.pmid: 20935643
references.citation: Neuropharmacology. 2013 May;68:122-35
references.pmid: 22981949
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:347-52
references.pmid: 23153507
references.citation: Nature. 2009 Oct 8;461(7265):802-8
references.pmid: 19812673
references.citation: Neurosci Lett. 1998 May 15;247(2-3):135-8
references.pmid: 9655611
references.citation: Autism Res. 2010 Dec;3(6):303-10
references.pmid: 21182207
references.citation: Neurosci Res. 2011 May;70(1):24-9
references.pmid: 21352859
references.citation: Front Synaptic Neurosci. 2014 Mar 18;6:4
references.pmid: 24672476
references.citation: Mol Brain. 2013;6:43
references.pmid: 24228616
references.citation: Mol Autism. 2011 Jan 19;2(1):1
references.pmid: 21247446
references.citation: Brain Res Bull. 1999 Nov 1;50(4):229-39
references.pmid: 10582521
references.citation: Eur J Neurosci. 2000 Mar;12(3):828-38
references.pmid: 10762312
references.citation: J Biol Chem. 2009 Mar 27;284(13):8495-506
references.pmid: 19164281
references.citation: J Neurosci. 2012 Jul 18;32(29):10021-34
references.pmid: 22815516
references.citation: Biomol Ther (Seoul). 2012 Jan;20(1):1-18
references.pmid: 24116269
references.citation: J Mol Neurosci. 2013 Oct;51(2):446-53
references.pmid: 23860687
references.citation: Med Hypotheses. 2011 Feb;76(2):184-6
references.pmid: 20888701
references.citation: Epilepsia. 1999 Nov;40(11):1566-71
references.pmid: 10565584
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2013 Dec;162B(8):779-88
references.pmid: 24039173
references.citation: J Neurosci. 2001 Jul 15;21(14):5139-46
references.pmid: 11438589
references.citation: Genes Brain Behav. 2010 Jun 1;9(4):402-10
references.pmid: 20132319
references.citation: Mol Biol (Mosk). 2015 Jan-Feb;49(1):89-98
references.pmid: 25916113
references.citation: Brain Res Rev. 2010 May;63(1-2):26-38
references.pmid: 20096729
references.citation: Trends Neurosci. 1997 Jun;20(6):264-8
references.pmid: 9185308
references.citation: Front Neuroanat. 2014 Nov 03;8:123
references.pmid: 25404897
references.citation: Curr Opin Neurobiol. 2012 Jun;22(3):397-404
references.pmid: 22019151
references.citation: Mol Psychiatry. 2006 Apr;11(4):325-6
references.pmid: 16446740
references.citation: Transl Psychiatry. 2013;3:e215
references.pmid: 23321812
references.citation: Science. 2014 May 30;344(6187):1020-3
references.pmid: 24831527
references.citation: Neuropsychopharmacology. 2007 Sep;32(9):1888-902
references.pmid: 17299517
references.citation: Cell. 2011 Jul 22;146(2):247-61
references.pmid: 21784246
references.citation: Neurosci Lett. 2015 Aug 5;601:46-53
references.pmid: 25478958
references.citation: Neurosci Lett. 2013 Nov 27;556:37-41
references.pmid: 24141084
references.citation: J Neurosci. 2000 Jun 1;20(11):4069-80
references.pmid: 10818142
references.citation: Neurochem Int. 2012 Dec;61(7):963-72
references.pmid: 22954428
references.citation: Ann Hum Genet. 2009 May;73(Pt 3):263-73
references.pmid: 19456320
references.citation: Biol Psychiatry. 2013 Sep 15;74(6):418-26
references.pmid: 23482246
references.citation: Mol Cell Neurosci. 2006 Apr;31(4):774-84
references.pmid: 16503162
references.citation: Hippocampus. 1993;3 Spec No:55-60
references.pmid: 8287112
references.citation: Neuroscience. 1992 Dec;51(4):801-13
references.pmid: 1488123
references.citation: J Cell Biol. 2012 Dec 10;199(6):985-1001
references.pmid: 23209303
references.citation: J Neurosci. 2006 Feb 15;26(7):1923-34
references.pmid: 16481424
references.citation: Neurodegener Dis. 2008;5(3-4):197-9
references.pmid: 18322389
references.citation: Biol Psychiatry. 2007 Oct 15;62(8):884-93
references.pmid: 17698040
references.citation: J Neurotrauma. 2004 Jul;21(7):932-43
references.pmid: 15307905
references.citation: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3221-6
references.pmid: 9501244
references.citation: Science. 2014 Aug 1;345(6196):1255263
references.pmid: 25082707
references.citation: Brain Res. 1994 Jan 28;635(1-2):307-11
references.pmid: 8173967
references.citation: Prog Brain Res. 2014;214:29-51
references.pmid: 25410352
references.citation: J Neurosci. 2010 Mar 31;30(13):4636-49
references.pmid: 20357114
references.citation: Mol Cell Neurosci. 2013 Sep;56:186-200
references.pmid: 23665579
references.citation: J Biochem. 1998 Mar;123(3):458-67
references.pmid: 9538229
references.citation: Am J Psychiatry. 2014 Sep;171(9):969-78
references.pmid: 24874453
references.citation: Development. 2007 Aug;134(15):2727-38
references.pmid: 17596283
references.citation: Nature. 2004 Jun 17;429(6993):761-6
references.pmid: 15190253
references.citation: J Neurochem. 2013 Jul;126(2):165-82
references.pmid: 23574039
references.citation: J Neurochem. 2006 Apr;97(1):44-56
references.pmid: 16515559
references.citation: Eur J Neurosci. 2010 Jun;31(12):2156-65
references.pmid: 20497467
references.citation: J Cell Biol. 1999 Feb 8;144(3):575-86
references.pmid: 9971750
references.citation: Neuroreport. 1992 Oct;3(10):869-72
references.pmid: 1421090
references.citation: J Neurosci. 2007 May 16;27(20):5338-48
references.pmid: 17507556
references.citation: Neuroscience. 2001;104(2):359-69
references.pmid: 11377840
references.citation: Nat Neurosci. 2012 Mar;15(3):414-22, S1-2
references.pmid: 22246436
references.citation: Neuropsychopharmacology. 2011 Sep;36(10):2103-10
references.pmid: 21677653
references.citation: Behav Brain Res. 2013 Apr 15;243:138-45
references.pmid: 23318464
references.citation: Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3556-61
references.pmid: 10725375
references.citation: Cell Rep. 2013 Jun 27;3(6):1815-23
references.pmid: 23770240
references.citation: Schizophr Res. 2014 Oct;159(1):118-23
references.pmid: 25205258
references.citation: Arch Gen Psychiatry. 2000 Nov;57(11):1061-9
references.pmid: 11074872
references.citation: Mol Neurobiol. 2008 Feb;37(1):73-82
references.pmid: 18438727
references.citation: Am J Psychiatry. 2004 Sep;161(9):1612-9
references.pmid: 15337651
references.citation: Neuropharmacology. 2012 Mar;62(4):1767-76
references.pmid: 22178614
references.citation: J Clin Invest. 1993 Aug;92(2):679-85
references.pmid: 8349806
references.citation: Nat Neurosci. 2001 Nov;4(11):1086-92
references.pmid: 11687814
references.citation: Annu Rev Neurosci. 2002;25:315-38
references.pmid: 12052912
references.citation: Neurochem Int. 2004 Sep;45(4):453-66
references.pmid: 15186911
references.citation: Rev Neurosci. 2012;23(1):97-109
references.pmid: 22718616
references.citation: Nat Genet. 2011 Oct;43(10):969-76
references.pmid: 21926974
references.citation: Nat Rev Neurosci. 2013 Aug;14(8):536-50
references.pmid: 23839597
references.citation: Neuropsychopharmacology. 2001 Jul;25(1):1-27
references.pmid: 11377916
references.citation: J Neurosci. 1989 Aug;9(8):2982-97
references.pmid: 2769375
references.citation: J Comp Neurol. 2006 Jun 10;496(5):706-22
references.pmid: 16615121
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11605-12
references.pmid: 18695242
references.citation: Int J Dev Neurosci. 2015 Aug;44:55-64
references.pmid: 25997908
references.citation: Autism Res. 2012 Dec;5(6):428-33
references.pmid: 23008271
references.citation: Neuron. 2013 Feb 6;77(3):388-405
references.pmid: 23395369
references.citation: Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16024-9
references.pmid: 14663137
references.citation: Cold Spring Harb Perspect Biol. 2011 Jan;3(1):a005108
references.pmid: 21123393
references.citation: Mol Psychiatry. 2008 Feb;13(2):162-72
references.pmid: 17579610
references.citation: Transl Psychiatry. 2015;5:e496
references.pmid: 25603412
references.citation: Nat Neurosci. 2009 Jul;12(7):897-904
references.pmid: 19483686
references.citation: Nat Genet. 1999 Oct;23(2):185-8
references.pmid: 10508514
references.citation: Dev Neurobiol. 2011 Nov;71(11):889-900
references.pmid: 21739613
references.citation: Exp Neurol. 1993 Jun;121(2):149-52
references.pmid: 8339766
references.citation: Mol Cell Biol. 2002 Nov;22(21):7417-27
references.pmid: 12370289
references.citation: Brain Res. 1995 Nov 6;698(1-2):265-9
references.pmid: 8581495
references.citation: Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):E305-12
references.pmid: 23269840
references.citation: BMC Med Genet. 2007;8:36
references.pmid: 17584923
references.citation: Biol Psychiatry. 2005 Apr 1;57(7):777-87
references.pmid: 15820235
references.citation: J Neurosci. 2006 Jul 19;26(29):7674-9
references.pmid: 16855095
references.citation: Expert Opin Ther Targets. 2015 Jan;19(1):77-85
references.pmid: 25214056
references.citation: Cell. 2003 Feb 7;112(3):317-27
references.pmid: 12581522
references.citation: J Biol Chem. 2013 Sep 20;288(38):27384-95
references.pmid: 23940048
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12578-83
references.pmid: 16113080
references.citation: Acta Neuropathol. 2010 Feb;119(2):211-20
references.pmid: 19636575
references.citation: Prog Brain Res. 2009;175:501-9
references.pmid: 19660677
references.citation: Nat Neurosci. 2010 Sep;13(9):1090-7
references.pmid: 20729843
references.citation: J Neurochem. 1995 Aug;65(2):762-9
references.pmid: 7616233
references.citation: Dev Neurobiol. 2007 Apr;67(5):570-88
references.pmid: 17443809
references.citation: Neuroreport. 2001 Oct 29;12(15):3209-15
references.pmid: 11711858
references.citation: Biochem J. 1995 Feb 15;306 ( Pt 1):177-84
references.pmid: 7864807
references.citation: J Neurosci. 2012 Dec 12;32(50):18009-17, 18017a
references.pmid: 23238717
references.citation: Neuroscience. 2002;112(4):773-81
references.pmid: 12088737
references.citation: Dev Neurobiol. 2014 Feb;74(2):178-96
references.pmid: 23908158
references.citation: Biochem Pharmacol. 2014 Apr 15;88(4):517-28
references.pmid: 24412275
references.citation: J Neurogenet. 2014 Mar-Jun;28(1-2):53-69
references.pmid: 24702465
references.citation: Front Cell Neurosci. 2015 May 15;9:154
references.pmid: 26029044
references.citation: Science. 1999 Oct 22;286(5440):735-41
references.pmid: 10531052
references.citation: Neuron. 2007 Nov 8;56(3):422-37
references.pmid: 17988628
references.citation: Annu Rev Neurosci. 2010;33:349-78
references.pmid: 20367247
references.citation: Am J Pathol. 1988 Dec;133(3):456-63
references.pmid: 2974240
references.citation: Neurochem Res. 2013 Jun;38(6):1113-21
references.pmid: 23124395
references.citation: Neurobiol Dis. 2001 Oct;8(5):723-42
references.pmid: 11592844
references.citation: Hippocampus. 2000;10(4):420-30
references.pmid: 10985281
references.citation: Biochem J. 2005 Feb 15;386(Pt 1):15-27
references.pmid: 15554875
references.citation: J Neurosci. 2004 Mar 17;24(11):2648-55
references.pmid: 15028757
references.citation: Cereb Cortex. 2000 Oct;10(10):1038-44
references.pmid: 11007554
references.citation: Harv Rev Psychiatry. 1996 Jan-Feb;3(5):241-53
references.pmid: 9384954
references.citation: PLoS One. 2009;4(5):e5505
references.pmid: 19430527
references.citation: BMC Neurosci. 2008;9:14
references.pmid: 18221525
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):873-7
references.pmid: 17346868
references.citation: Schizophr Res. 2007 Feb;90(1-3):41-51
references.pmid: 17156977
references.citation: Am J Psychiatry. 2004 Oct;161(10):1848-55
references.pmid: 15465982
references.citation: J Chem Neuroanat. 2010 Nov;40(3):243-7
references.pmid: 20621181
references.citation: Arch Gen Psychiatry. 1995 Dec;52(12):1015-8; discussion 1019-24
references.pmid: 7492253
references.citation: Brain Res. 2015 Dec 2;1628(Pt A):29-39
references.pmid: 25838241
references.citation: Neuropharmacology. 2012 Mar;62(3):1584-97
references.pmid: 21856318
references.citation: Science. 2004 Oct 15;306(5695):487-91
references.pmid: 15486301
references.citation: Int J Dev Neurosci. 2005 Apr-May;23(2-3):221-34
references.pmid: 15749247
references.citation: Nature. 2009 May 28;459(7246):528-33
references.pmid: 19404256
references.citation: Am J Psychiatry. 2006 Mar;163(3):540-2
references.pmid: 16513881
references.citation: Synapse. 2005 Jul;57(1):47-55
references.pmid: 15858835
references.citation: Cold Spring Harb Perspect Biol. 2011 Dec;3(12). pii: a005678. doi: 10.1101/cshperspect.a005678
references.pmid: 22046028
references.citation: Mol Psychiatry. 2013 Nov;18(11):1185-92
references.pmid: 23070074
references.citation: Neuropharmacology. 2011 Jun;60(7-8):1007-16
references.pmid: 21074545
references.citation: Transl Psychiatry. 2013;3:e270
references.pmid: 23756379
references.citation: Nat Med. 2001 Jan;7(1):59-64
references.pmid: 11135617
references.citation: Am J Hum Genet. 2011 Mar 11;88(3):372-81
references.pmid: 21353194
references.citation: Acta Neuropathol. 2005 Oct;110(4):393-401
references.pmid: 16133543
references.citation: Mol Psychiatry. 2014 Jan;19(1):30-6
references.pmid: 24217255
references.citation: Arch Gen Psychiatry. 1993 Mar;50(3):169-77
references.pmid: 7679891
references.citation: PLoS One. 2012;7(8):e42676
references.pmid: 22880079
references.citation: J Neurosci. 1988 Dec;8(12):4455-69
references.pmid: 3199186
references.citation: J Neurosci. 2013 Nov 13;33(46):18234-41
references.pmid: 24227732
references.citation: Neurosci Res. 2009 Apr;63(4):227-35
references.pmid: 19367784
references.citation: Schizophr Bull. 2015 Sep;41(5):1003-9
references.pmid: 25837304
references.citation: Neurosci Lett. 1989 Dec 15;107(1-3):211-5
references.pmid: 2616032
references.citation: Neurobiol Dis. 2014 Oct;70:179-89
references.pmid: 25008761
references.citation: FASEB J. 2004 Jun;18(9):1013-5
references.pmid: 15084524
references.citation: Orv Hetil. 2013 Jul 7;154(27):1067-73; quiz 1078-9
references.pmid: 23816895
references.citation: Neurobiol Dis. 2004 Aug;16(3):604-16
references.pmid: 15262273
references.citation: Mol Cell Biol. 2001 Sep;21(17):5970-8
references.pmid: 11486035
references.citation: J Neurosci. 2010 Oct 27;30(43):14560-72
references.pmid: 20980614
references.citation: Nat Rev Neurosci. 2010 Nov;11(11):735-46
references.pmid: 20944663
references.citation: Am J Pathol. 1994 Feb;144(2):337-47
references.pmid: 8311117
references.citation: Biol Psychiatry. 2007 Aug 15;62(4):359-62
references.pmid: 17210139
references.citation: Am J Pathol. 1999 Dec;155(6):2115-25
references.pmid: 10595940
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19520-5
references.pmid: 19047646
references.citation: Biol Psychiatry. 2015 Jun 15;77(12):1031-40
references.pmid: 25863358
references.citation: Mol Psychiatry. 2005 Jun;10(6):563-71
references.pmid: 15558079
references.citation: Biol Psychiatry. 2003 Nov 15;54(10):1015-24
references.pmid: 14625143
references.citation: J Neurosci. 2014 Apr 30;34(18):6164-76
references.pmid: 24790187
references.citation: JAMA Psychiatry. 2015 Aug;72(8):747-56
references.pmid: 26038830
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):767-9
references.pmid: 15939521
references.citation: Hum Mol Genet. 2010 Oct 15;19(20):4072-82
references.pmid: 20663923
references.citation: Neuron. 1999 Oct;24(2):471-9
references.pmid: 10571240
references.citation: J Neurosci. 1996 Feb 15;16(4):1380-8
references.pmid: 8778289
references.citation: Nat Rev Neurosci. 2005 Apr;6(4):312-24
references.pmid: 15803162
references.citation: Neuroscience. 2013 Oct 22;251:33-50
references.pmid: 23036622
references.citation: J Neurosci. 2012 Jul 4;32(27):9429-37
references.pmid: 22764251
references.citation: Trends Mol Med. 2006 Oct;12(10):488-96
references.pmid: 16962376
references.citation: J Alzheimers Dis. 2011;24(4):705-19
references.pmid: 21321391
references.citation: Biol Psychiatry. 2013 Sep 15;74(6):427-35
references.pmid: 23790226
references.citation: Genomics. 2006 Jan;87(1):75-83
references.pmid: 16311013
references.citation: Biol Psychiatry. 2007 May 15;61(10):1200-3
references.pmid: 17067558
references.citation: Dev Neurobiol. 2011 Nov;71(11):1073-89
references.pmid: 21898855
references.citation: J Clin Invest. 2013 Jun;123(6):2523-38
references.pmid: 23676497
references.citation: Curr Opin Pharmacol. 2014 Feb;14:97-102
references.pmid: 24524997
references.citation: J Neurosci Res. 2012 Feb;90(2):376-87
references.pmid: 21959900
references.citation: Acta Neuropathol. 1988;76(2):142-58
references.pmid: 2900587
references.citation: Schizophr Res. 2016 Sep;176(1):41-51
references.pmid: 25000913
references.citation: J Neurosci. 2006 Dec 13;26(50):12943-55
references.pmid: 17167084
references.citation: Transl Psychiatry. 2011;1:e8
references.pmid: 22832403
references.citation: Neuron. 2010 May 13;66(3):337-51
references.pmid: 20471348
references.citation: Brain Res Mol Brain Res. 2002 Apr 30;100(1-2):103-17
references.pmid: 12008026
references.citation: Adv Exp Med Biol. 2012;970:153-71
references.pmid: 22351055
references.citation: Nat Commun. 2013;4:1484
references.pmid: 23403561
references.citation: Prog Neurobiol. 2004 Oct;74(2):101-10
references.pmid: 15518955
references.citation: Mol Neurobiol. 2014 Feb;49(1):484-511
references.pmid: 23999870
references.citation: Schizophr Res. 2013 Nov;150(2-3):366-72
references.pmid: 24035561
references.citation: Neuroscience. 2007 Jan 5;144(1):8-16
references.pmid: 17049177
references.citation: J Med Genet. 2009 Feb;46(2):94-102
references.pmid: 18835858
references.citation: Schizophr Res. 2015 Sep;167(1-3):18-27
references.pmid: 25601362
references.citation: J Neurosci. 2006 Feb 15;26(7):2041-52
references.pmid: 16481437
references.citation: Proc Natl Acad Sci U S A. 2013 May 28;110(22):9130-5
references.pmid: 23671099
references.citation: Int J Neuropsychopharmacol. 2014 Oct;17(10):1635-46
references.pmid: 24786752
references.citation: Mol Psychiatry. 2003 Feb;8(2):148-55
references.pmid: 12610647
references.citation: Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a001867
references.pmid: 20519341
references.citation: J Neurosci. 2006 Jan 4;26(1):319-27
references.pmid: 16399702
references.citation: Neurology. 1993 Jun;43(6):1073-7
references.pmid: 8170544
references.citation: Mol Psychiatry. 2000 Nov;5(6):654-63, 571
references.pmid: 11126396
references.citation: Mol Psychiatry. 2005 Mar;10(3):251-7
references.pmid: 15583703
references.citation: Brain Dev. 2010 Oct;32(9):731-8
references.pmid: 20570072
references.citation: Pediatr Neonatol. 2011 Dec;52(6):309-16
references.pmid: 22192257
references.citation: Arch Gen Psychiatry. 2000 Jan;57(1):65-73
references.pmid: 10632234
references.citation: Exp Neurol. 2003 Nov;184(1):179-95
references.pmid: 14637091
references.citation: EMBO J. 1999 Jun 1;18(11):3007-12
references.pmid: 10357813
references.citation: Arch Gen Psychiatry. 2010 Feb;67(2):155-66
references.pmid: 20124115
references.citation: Neuroscience. 2013 May 15;238:168-84
references.pmid: 23428622
references.citation: Lancet Neurol. 2002 Oct;1(6):352-8
references.pmid: 12849396
references.citation: Glia. 1993 Jul;8(3):183-200
references.pmid: 7693589
references.citation: Acta Psychiatr Scand. 2000 Nov;102(5):321-30
references.pmid: 11098802
references.citation: Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15718-23
references.pmid: 9861036
references.citation: J Cell Sci. 2011 Oct 1;124(Pt 19):3369-80
references.pmid: 21896646
references.citation: Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15201-6
references.pmid: 15475576
references.citation: Am J Med Genet A. 2013 Aug;161A(8):1897-903
references.pmid: 23824974
references.citation: Curr Opin Neurobiol. 2011 Apr;21(2):353-9
references.pmid: 21277196
references.citation: J Child Neurol. 1993 Oct;8(4):316-22
references.pmid: 7693796
references.citation: Schizophr Res. 2005 Jan 1;72(2-3):109-22
references.pmid: 15560956
references.citation: Am J Psychiatry. 2001 Sep;158(9):1367-77
references.pmid: 11532718
references.citation: Chemistry. 2013 May 17;19(21):6817-23
references.pmid: 23553710
references.citation: Neuron. 1998 Oct;21(4):813-25
references.pmid: 9808467
references.citation: Am J Psychiatry. 1979 Oct;136(10):1310-2
references.pmid: 484727
references.citation: J Autism Dev Disord. 2001 Dec;31(6):529-35
references.pmid: 11814262
references.citation: Neurosci Lett. 2001 Nov 2;313(1-2):96-8
references.pmid: 11684348
references.citation: J Neuropathol Exp Neurol. 1967 Jan;26(1):150-1
references.pmid: 6022142
references.citation: J Cell Biol. 2000 Oct 2;151(1):53-68
references.pmid: 11018053
references.citation: Pediatrics. 1991 Dec;88(6):1219-25
references.pmid: 1956740
references.citation: CNS Neurol Disord Drug Targets. 2015;14(3):325-30
references.pmid: 25714971
references.citation: Handb Exp Pharmacol. 2012;(213):267-95
references.pmid: 23027419
references.citation: Am J Med Genet. 2001 Jan 15;98(2):161-7
references.pmid: 11223852
references.citation: Br J Psychiatry. 1983 Sep;143:256-60
references.pmid: 6684962
references.citation: Arch Gen Psychiatry. 1995 Dec;52(12):998-1007
references.pmid: 7492260
references.citation: Neuron. 2004 Dec 2;44(5):759-67
references.pmid: 15572108
references.citation: Am J Psychiatry. 2001 Feb;158(2):256-65
references.pmid: 11156808
references.citation: Eur J Neurosci. 2010 May;31(9):1511-8
references.pmid: 20525064
references.citation: Schizophr Res. 2012 Jun;138(1):69-73
references.pmid: 22497794
references.citation: Nat Med. 1996 Aug;2(8):864-70
references.pmid: 8705854
references.citation: Front Biosci (Landmark Ed). 2010;15:626-44
references.pmid: 20036837
references.citation: Annu Rev Biochem. 1994;63:571-600
references.pmid: 7979248
references.citation: Neuropsychobiology. 2012;66(1):57-62
references.pmid: 22797278
references.citation: Front Neuroanat. 2014 Oct 20;8:116
references.pmid: 25368556
references.citation: PLoS One. 2010;5(2):e9166
references.pmid: 20161799
references.citation: Proc Natl Acad Sci U S A. 2014 May 6;111(18):6810-5
references.pmid: 24753587
references.citation: J Cell Biol. 2007 Jun 4;177(5):829-41
references.pmid: 17548511
references.citation: Nat Rev Neurosci. 2003 Jun;4(6):496-505
references.pmid: 12778121
references.citation: Schizophr Res. 2007 Nov;96(1-3):46-61
references.pmid: 17698324
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):60-6
references.pmid: 15717292
references.citation: Am J Psychiatry. 2012 Sep;169(9):982-90
references.pmid: 22952076
references.citation: Acta Neuropathol. 1985;67(3-4):289-95
references.pmid: 4050344
references.citation: J Biol Chem. 2006 Jun 30;281(26):17789-800
references.pmid: 16644727
references.citation: Cold Spring Harb Perspect Biol. 2012 May;4(5). pii: a005587. doi: 10.1101/cshperspect.a005587
references.pmid: 22357909
references.citation: J Anat. 2004 Jan;204(1):33-48
references.pmid: 14690476
references.citation: J Neurobiol. 2006 May;66(6):564-77
references.pmid: 16555239
references.citation: Front Psychiatry. 2013 Oct 21;4:139
references.pmid: 24155727
references.citation: Biol Psychiatry. 2015 Sep 15;78(6):374-85
references.pmid: 25818630
references.citation: J Med Genet. 2004 Jan;41(1):25-30
references.pmid: 14729826
references.citation: Biol Psychiatry. 2008 Nov 1;64(9):803-9
references.pmid: 18585682
references.citation: Nature. 2013 Dec 12;504(7479):272-6
references.pmid: 24336286
references.citation: Neurosci Lett. 2012 Jan 11;506(2):208-13
references.pmid: 22100909
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18201-6
references.pmid: 16330749
references.citation: J Affect Disord. 2013 Apr 5;146(2):286-9
references.pmid: 22858217
references.citation: J Neural Transm. 1977;40(2):159-70
references.pmid: 140216