title: Thalamic mediation of hypoxic respiratory depression in lambs.
abstract: Immaturity of respiratory controllers in preterm infants dispose to recurrent apnea and oxygen deprivation. Accompanying reductions in brain oxygen tensions evoke respiratory depression, potentially exacerbating hypoxemia. Central respiratory depression during moderate hypoxia is revealed in the ventilatory decline following initial augmentation. This study determined whether the thalamic parafascicular nuclear (Pf) complex involved in adult nociception and sensorimotor regulation (Bentivoglio M, Balerecia G, Kruger L. Prog Brain Res 87: 53-80, 1991) also becomes a postnatal controller of hypoxic ventilatory decline. Respiratory responses to moderate isocapnic hypoxia were studied in conscious lambs. Hypoxic ventilatory decline was compared with peak augmentation. Pf and/or adjacent thalamic structures were destroyed by the neuron-specific toxin ibotenic acid (IB). IB lesions involving the thalamic Pf abolished hypoxic ventilatory decline. Lesions of adjacent thalamic nuclei that spared Pf and control injections of vehicle failed to blunt hypoxic respiratory depression. Our findings reveal that the thalamic Pf region is a critical controller of hypoxic ventilatory depression and thus a key target for exploring molecular concomitants of forebrain pathways regulating hypoxic ventilatory depression in early development.
authors.affiliation: Department of Obstetrics & Gynecology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California; bkoos@mednet.ucla.edu.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Koos
authors.affiliation: Department of Obstetrics & Gynecology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California;
authors.forename: Arezoo
authors.initials: A
authors.lastname: Rajaee
authors.affiliation: Department of Pediatrics, C. W. Steers Biological Resource Center, Los Angeles Biomedical Research Institute, Harbor-University of California Los Angeles Medical Center, Torrance, California; and.
authors.forename: Basil
authors.initials: B
authors.lastname: Ibe
authors.affiliation: C. W. Steers Biological Resource Center, Los Angeles Biomedical Research Institute, Harbor-University of California Los Angeles Medical Center, Torrance, California.
authors.forename: Catalina
authors.initials: C
authors.lastname: Guerra
authors.affiliation: Department of Neurobiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California;
authors.forename: Lawrence
authors.initials: L
authors.lastname: Kruger
mesh_terms: D000818:Animals; D025461:Feedback, Physiological; D005260:Female; D005311:Fetal Hypoxia / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D011659:Pulmonary Gas Exchange; D012125:Respiratory Center / Q000503:physiopathology*; D012756:Sheep; D013788:Thalamus / Q000503:physiopathology*
chemical_list: D010100:Oxygen
keywords: biphasic ventilation; brain; hypoxia; respiratory inhibition; sheep; thalamus
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