title: Sonochemical enzyme-catalyzed regioselective acylation of flavonoid glycosides.
abstract: This work compares a highly efficient and alternative method of sonication-assisted lipase catalyzed acylation of quercetin-3-O-glucoside and phloretin-2'-glucoside, using Candida antarctica lipase B (Novozyme 435(®)), with a range of fatty acids. In this study, sonication-assisted irradiation coupled with stirring has been found to be more efficient and economical than conventional reaction conditions. Sonication-assisted acylation accelerated the reactions and reduced the time required by 4-5 folds.
authors.affiliation: Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, Nova Scotia B2N 5E3, Canada.
authors.lastname: Ziaullah
authors.affiliation: Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, Nova Scotia B2N 5E3, Canada. Electronic address: vrupasinghe@dal.ca.
authors.forename: H P Vasantha
authors.initials: HP
authors.lastname: Rupasinghe
mesh_terms: D000215:Acylation; D055162:Biocatalysis; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism*; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism*; D006027:Glycosides / Q000737:chemistry / Q000378:metabolism*; D008049:Lipase / Q000737:chemistry / Q000378:metabolism*; D008968:Molecular Conformation; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D005419:Flavonoids; D005656:Fungal Proteins; D006027:Glycosides; D008049:Lipase; C431349:lipase B, Candida antarctica
keywords: Acylation; Candida antarctica lipase B; Flavonoids; Isoquercitrin; NMR spectroscopy; Phloridzin; Sonication-assisted irradiation