title: [A case of light and heavy chain deposition disease].
abstract: Monoclonal immunoglobulin deposition disease is rare in medical practice. The light and heavy chain deposition disease is characterized by deposition of monoclonal antibodies in the basement of membrane. Kidney is the most frequently involved organ. There was a male patient diagnosed as light and heavy chain deposition disease in department of Nephrology of the Second Xiangya Hospital, Central South University by renal biopsy. After treatment by oral prednisone, melphalan and thalidomide, the patient's proteinuria and serum creatinine decreased. The retrospective analysis of this case provides a guide for doctors to understand the light and heavy chain deposition disease. Early diagnosis and treatment could improve the prognosis.
authors.affiliation: Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Nephrology, Anhua Hospital of Traditional Chinese Medicine, Anhua Hunan 413500, China.
authors.forename: Yueliang
authors.initials: Y
authors.lastname: Long
authors.affiliation: Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Letian
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects; D001485:Basement Membrane / Q000503:physiopathology; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D006362:Heavy Chain Disease / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007147:Immunoglobulin Light Chains; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D011507:Proteinuria
chemical_list: D000911:Antibodies, Monoclonal; D007147:Immunoglobulin Light Chains; D003404:Creatinine