title: Type 2 diabetes mellitus and risk of hydrocephalus: A 5 year population-based follow-up study in Taiwan.
abstract: OBJECTIVE
  Type 2 diabetes mellitus (T2DM) involves many organ systems and is associated with a wide range of neurologic complications. However, it is not known whether T2DM is a risk factor of hydrocephalus.
  
  
  METHODS
  Research data were retrieved from the National Health Insurance Research Database of Taiwan. A total of 25,903 individuals with T2DM aged 40-80 years diagnosed during 2000-2003 and two times-number (n=51,806) age- and sex-matched comparisons during the same period were included. We tracked all individuals from their defined index visits for up to 5 years to detect a new diagnosis of hydrocephalus.
  
  
  RESULTS
  Among the 25,903 patients, 9227 cases were newly diagnosed T2DM and 16,676 were pre-existing T2DM patients. During the follow-up period, 27 (0.3%) of the newly diagnosed T2DM patients, 97 (0.6%) of the pre-existing T2DM patients and 149 (0.3%) of the comparison group developed hydrocephalus. The risk of hydrocephalus was significantly increased in patients with pre-existing diabetes but not in patients with newly diagnosed diabetes.
  
  
  CONCLUSIONS
  Longer duration of type 2 diabetes is associated with an increased risk of the development of hydrocephalus. Further studies to confirm such association and to investigate the causality and mechanism are needed.
authors.affiliation: Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Chien-Hsu
authors.initials: CH
authors.lastname: Lai
authors.affiliation: Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: yychen@mail2000.com.tw.
authors.forename: Yen-Yu
authors.initials: YY
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006849:Hydrocephalus / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
keywords: DM; Diabetes; Hydrocephalus; National Health Insurance Research; Risk factors