title: Association between MUC5B polymorphism and susceptibility and severity of idiopathic pulmonary fibrosis.
abstract: OBJECTIVE
  Idiopathic pulmonary fibrosis (IPF) is a group of lung diseases that cause irreversible architectural distortion and impair gas, and finally progressive pulmonary functional decline and death, in which the common variant in the promoter region of the mucin 5B (MUC5B) gene may be involved. The present study aims to investigate whether variants within the MUC5B gene rs35705950 contributed to IPF susceptibility and severity in Chinese Han Population.
  
  
  METHODS
  A total of 187 patients diagnosed with IPF and 250 healthy controls were enrolled in this study. All subjects were genotyped for MUV5B SNP rs35705950. The demographic, comorbidity, clinical and functional data were recorded.
  
  
  RESULTS
  The rs35705950 of MUC5B were found significantly associated with increased risk of IPF susceptibility. One way ANOVA analysis found that there was a significant decreased FVC (P < 0.0001) and DLco (P < 0.0001) in correction with the minor allele of the SNP rs35705950. In the 5 years' follow-up, the carriers of the minor allele T increased mortality (P = 0.0294).
  
  
  CONCLUSIONS
  This study demonstrated that the MUC5B polymorphism rs35705950 is associated with increased risk of idiopathic pulmonary fibrosis susceptibility, severity, and the decreased overall survival.
authors.affiliation: Department of Emergency, Qilu Hospital, Shandong UniversityJinan, China; Yantai Affiliated Hospital of Binzhou Medical UniversityYantai, China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Jiang
authors.affiliation: School of Medical Science, Binzhou Medical University Yantai, China.
authors.forename: Yejia
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Yantai Affiliated Hospital of Binzhou Medical University Yantai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shang
authors.affiliation: Yantai Affiliated Hospital of Binzhou Medical University Yantai, China.
authors.forename: Yuzhu
authors.initials: Y
authors.lastname: Li
authors.affiliation: Yantai Affiliated Hospital of Binzhou Medical University Yantai, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Emergency, Qilu Hospital, Shandong UniversityJinan, China; Chest Pain Center, Qilu Hospital, Shandong UniversityJinan, China; Institute of Emergency and Critical Care Medicine, Shandong UniversityJinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong UniversityJinan, China; Key Laboratory of Cardiovascular Remodeling & Function Research, Chinese Ministry of Education & Chinese Ministry of Public Health, Qilu Hospital, Shandong UniversityJinan, China.
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000235:genetics* / Q000401:mortality; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D055257:Mucin-5B / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models
chemical_list: C524578:MUC5B protein, human; D055257:Mucin-5B
keywords: MUC5B; SNP; idiopathic pulmonary fibrosis
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