title: N-3 Polyunsaturated Fatty Acids of Marine Origin and Multifocality in Human Breast Cancer.
abstract: OBJECTIVE
  The microenvironment of breast epithelial tissue may contribute to the clinical expression of breast cancer. Breast epithelial tissue, whether healthy or tumoral, is directly in contact with fat cells, which in turn could influence tumor multifocality. In this pilot study we investigated whether the fatty acid composition of breast adipose tissue differed according to breast cancer focality.
  
  
  METHODS
  Twenty-three consecutive women presenting with non-metastatic breast cancer underwent breast-imaging procedures including Magnetic Resonance Imaging prior to treatment. Breast adipose tissue specimens were collected during breast surgery. We established a biochemical profile of adipose tissue fatty acids by gas chromatography. We assessed whether there were differences according to breast cancer focality.
  
  
  RESULTS
  We found that decreased levels in breast adipose tissue of docosahexaenoic and eicosapentaenoic acids, the two main polyunsaturated n-3 fatty acids of marine origin, were associated with multifocality.
  
  
  CONCLUSIONS
  These differences in lipid content may contribute to mechanisms through which peritumoral adipose tissue fuels breast cancer multifocality.
authors.affiliation: Department of Gynecology, Centre Hospitalier Universitaire de Tours, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, Tours, France.|INSERM UMR1069, 10 boulevard Tonnellé, 37044, Tours, France.|François-Rabelais University, 10 boulevard Tonnellé, 37044, Tours, France.
authors.forename: Lobna
authors.initials: L
authors.lastname: Ouldamer
authors.affiliation: INSERM UMR1069, 10 boulevard Tonnellé, 37044, Tours, France.|François-Rabelais University, 10 boulevard Tonnellé, 37044, Tours, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Goupille
authors.affiliation: Department of Radiology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, Tours, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Vildé
authors.affiliation: Department of Pathology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, Tours, France.
authors.forename: Flavie
authors.initials: F
authors.lastname: Arbion
authors.affiliation: Department of Gynecology, Centre Hospitalier Universitaire de Tours, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, Tours, France.|François-Rabelais University, 10 boulevard Tonnellé, 37044, Tours, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Body
authors.affiliation: INSERM UMR1069, 10 boulevard Tonnellé, 37044, Tours, France.|François-Rabelais University, 10 boulevard Tonnellé, 37044, Tours, France.
authors.forename: Stephan
authors.initials: S
authors.lastname: Chevalier
authors.affiliation: François-Rabelais University, 10 boulevard Tonnellé, 37044, Tours, France.|Department of Radiology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, Tours, France.|INSERM UMR930, 10 boulevard Tonnellé, 37044, Tours, France.
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Cottier
authors.affiliation: INSERM UMR1069, 10 boulevard Tonnellé, 37044, Tours, France.|François-Rabelais University, 10 boulevard Tonnellé, 37044, Tours, France.|Department of Oncology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, Tours, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bougnoux
mesh_terms: D052436:Adipose Tissue, White / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D004032:Diet; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000378:metabolism*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D042361:Mammary Glands, Human / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D011446:Prospective Studies; D059016:Tumor Microenvironment
chemical_list: D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid
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