title: Hepatocellular Carcinoma: Histologic Subtypes.
abstract: This review discusses the various histologic subtypes of hepatocellular carcinoma (HCC), focusing on their clinical features, pathologic features, immunohistochemical profiles, differential diagnosis, prognosis, and clinical relevance of diagnosis. The WHO recognized variants of scirrhous HCC, fibrolamellar carcinoma, combined HCC-cholangiocarcinoma (HCC-CC), sarcomatoid HCC, undifferentiated carcinoma, and lymphoepithelioma-like HCC are discussed in detail. Other subtypes including clear cell HCC, diffuse cirrhosis-like HCC, steatohepatitic HCC, transitional liver cell tumor, and CAP carcinoma are also reviewed.
authors.affiliation: Department of Pathology, Woodland Hills Medical Center, 5601 De Soto Avenue, Woodland Hills, CA 91365, USA.
authors.forename: Nafis
authors.initials: N
authors.lastname: Shafizadeh
authors.affiliation: Department of Pathology, Veterans Administration Medical Center, University of California, San Francisco, 113B, 4150 Clement Street, San Francisco, CA 94121, USA. Electronic address: sanjay.kakar@ucsf.edu.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kakar