title: Kaempferol as Selective Human MAO-A Inhibitor: Analytical Detection in Calabrian Red Wines, Biological and Molecular Modeling Studies.
abstract: The purpose of this work was to determine the kaempferol content in three red wines of Calabria, a southern Italian region with a great number of certified food products. Considering that wine cultivar, climate, and soil influence the qualitative and quantitative composition in flavonoids of Vitis vinifera L. berries, the three analyzed samples were taken from the 2013 vintage. Moreover, the Gaglioppo samples, with assigned Controlled Origin Denomination (DOC), were also investigated in the production of years 2008, 2010, and 2011. In addition to the analysis of kaempferol, which is present in higher concentration than in other Italian wines, in vitro assays were performed to evaluate, for the first time, the inhibition of the human monoamine oxidases (hMAO-A and hMAO-B). Molecular recognition studies were also carried out to provide insight into the binding mode of kaempferol and selectivity of inhibition of the hMAO-A isoform.
authors.affiliation: Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro , Campus Universitario "S. Venuta", Viale Europa, Loc. Germaneto, 88100 Catanzaro, Italy.
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Gidaro
authors.affiliation: Dipartimento ARPACal di Crotone , via E. Fermi s.n.c., 88900 Crotone, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Astorino
authors.affiliation: Centre of Excellence for Pharmaceutical Sciences, North-west University , Potchefstroom 2520, South Africa.
authors.forename: Anél
authors.initials: A
authors.lastname: Petzer
authors.affiliation: Department of Pharmacy, "G. D'Annunzio" University of Chieti-Pescara , Via dei Vestini 31, 66100 Chieti, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Carradori
authors.affiliation: Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro , Campus Universitario "S. Venuta", Viale Europa, Loc. Germaneto, 88100 Catanzaro, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Alcaro
authors.affiliation: Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro , Campus Universitario "S. Venuta", Viale Europa, Loc. Germaneto, 88100 Catanzaro, Italy.
authors.forename: Giosuè
authors.initials: G
authors.lastname: Costa
authors.affiliation: Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro , Campus Universitario "S. Venuta", Viale Europa, Loc. Germaneto, 88100 Catanzaro, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Artese
authors.affiliation: Slow Wine , Via di Mendicità Istruita, 12042 Bra (Cuneo), Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Rafele
authors.affiliation: Dipartimento ARPACal di Crotone , via E. Fermi s.n.c., 88900 Crotone, Italy.
authors.forename: Francesco M
authors.initials: FM
authors.lastname: Russo
authors.affiliation: Centre of Excellence for Pharmaceutical Sciences, North-west University , Potchefstroom 2520, South Africa.
authors.forename: Jacobus P
authors.initials: JP
authors.lastname: Petzer
authors.affiliation: Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro , Campus Universitario "S. Venuta", Viale Europa, Loc. Germaneto, 88100 Catanzaro, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Alcaro
mesh_terms: D006801:Humans; D007558:Italy; D044949:Kaempferols / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D008995:Monoamine Oxidase / Q000737:chemistry; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry*; D014920:Wine / Q000032:analysis*
chemical_list: D044949:Kaempferols; D008996:Monoamine Oxidase Inhibitors; C006552:kaempferol; D008995:Monoamine Oxidase
keywords: computational chemistry; flavonoids; inhibition; monoamine oxidase; red wine