title: Co-occurrence of biphenotypic acute leukaemia, glucose 6-phosphate dehydrogenase deficiency and haemoglobin E trait in a single child.
abstract: Acute leukaemias occur as the result of clonal expansion subsequent to transformation and arrest at a normal differentiation stage of haematopoietic precursors, which commit to a single lineage, such as myeloid or B-lymphoid or T-lymphoid cells. Biphenotypic acute leukaemia (BAL) constitutes a biologically different group of leukaemia arising from a precursor stem cell and co-expressing more than one lineage specific marker. The present report describes a child with unusual co-occurrence of biphenotypic (B-precursor cell and Myeloid) acute leukaemia, haemoglobin E trait and glucose 6-phosphate dehydrogenase (G6-PD) deficiency. To the best of our knowledge, this constellation of haematological conditions in a single child has never been described before.
authors.affiliation: Department of Paediatric Medicine, HEEM, Boston, UK.
authors.forename: Debkrishna
authors.initials: D
authors.lastname: Mallick
authors.affiliation: Department of Pediatrics, Golisano Children's Hospital, Syracuse, New York, USA.
authors.forename: Rajoo
authors.initials: R
authors.lastname: Thapa
authors.affiliation: Department of Pediatrics, Institute of Child Health, Kolkata, West Bengal, India.
authors.forename: Biswajit
authors.initials: B
authors.lastname: Biswas
mesh_terms: D002675:Child, Preschool; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D006446:Hemoglobin E / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D015456:Leukemia, Biphenotypic, Acute / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D008297:Male; D010290:Parents / Q000523:psychology*; D054448:Precursor Cells, B-Lymphoid / Q000276:immunology*; D011379:Prognosis; D016312:Treatment Refusal
chemical_list: D006446:Hemoglobin E
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