title: A novel dextran polymer hydrogel local antimicrobial therapy in dogs: A pilot study.
abstract: Our purpose was to evaluate physical, laboratory, and/or radiographic abnormalities associated with a novel dextran polymer hydrogel local antimicrobial agent impregnated with amikacin and clindamycin in dogs having tibial plateau leveling osteotomy implants removed due to suspected surgical site infection. A total of 28 client-owned dogs were enrolled and 20 completed the study. Routine plate explantation and bacterial cultures were performed and the polymer hydrogel was applied to the surgery site. No systemic antimicrobials were used after surgery. Serum biochemistry, hematology, urinalysis, physical examinations, and radiographs were monitored before surgery and up to 12 wk after surgery. Sixteen of the 20 dogs (80%) had a positive bacterial culture, 44% of which were methicillin resistant. There were no significant alterations of laboratory values, physical examination, or radiographs to indicate adverse reactions to the polymer hydrogel. There were no signs of inflammation or infection in any patient at the 12-week postoperative recheck.
authors.affiliation: Chesapeake Veterinary Surgical Specialists, 1209 Cromwell Bridge Road, Towson, Maryland 21286, USA (Reed, Weeren, Anders); Veterinary Surgical Specialists, 7512 Paula Drive, Tampa, Florida 33615, USA (Thomas); Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, 205 Duck Pond Drive, Blacksburg, Virginia 24061, USA (Ruth).
authors.forename: Travis P
authors.initials: TP
authors.lastname: Reed
authors.affiliation: Chesapeake Veterinary Surgical Specialists, 1209 Cromwell Bridge Road, Towson, Maryland 21286, USA (Reed, Weeren, Anders); Veterinary Surgical Specialists, 7512 Paula Drive, Tampa, Florida 33615, USA (Thomas); Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, 205 Duck Pond Drive, Blacksburg, Virginia 24061, USA (Ruth).
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Thomas
authors.affiliation: Chesapeake Veterinary Surgical Specialists, 1209 Cromwell Bridge Road, Towson, Maryland 21286, USA (Reed, Weeren, Anders); Veterinary Surgical Specialists, 7512 Paula Drive, Tampa, Florida 33615, USA (Thomas); Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, 205 Duck Pond Drive, Blacksburg, Virginia 24061, USA (Ruth).
authors.forename: F Robert
authors.initials: FR
authors.lastname: Weeren
authors.affiliation: Chesapeake Veterinary Surgical Specialists, 1209 Cromwell Bridge Road, Towson, Maryland 21286, USA (Reed, Weeren, Anders); Veterinary Surgical Specialists, 7512 Paula Drive, Tampa, Florida 33615, USA (Thomas); Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, 205 Duck Pond Drive, Blacksburg, Virginia 24061, USA (Ruth).
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Ruth
authors.affiliation: Chesapeake Veterinary Surgical Specialists, 1209 Cromwell Bridge Road, Towson, Maryland 21286, USA (Reed, Weeren, Anders); Veterinary Surgical Specialists, 7512 Paula Drive, Tampa, Florida 33615, USA (Thomas); Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, 205 Duck Pond Drive, Blacksburg, Virginia 24061, USA (Ruth).
authors.forename: Brendan B
authors.initials: BB
authors.lastname: Anders
mesh_terms: D000583:Amikacin / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D003911:Dextrans / Q000737:chemistry*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D020100:Hydrogels; D008297:Male; D010865:Pilot Projects; D013530:Surgical Wound Infection / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents; D003911:Dextrans; D020100:Hydrogels; D002981:Clindamycin; D000583:Amikacin
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