title: A Digital Squamous Cell Carcinoma Mimicking a Diabetic Foot Ulcer, With Early Inguinal Metastasis and Cancer-Related Lymphedema.
abstract: Although squamous cell carcinoma (SCC) is the second most common nonmelanoma skin cancer, clinicians have difficulty diagnosing SCC of the toe because its clinical features can mimic other less serious diseases. Clinicians are especially prone to misdiagnose SCC of the toe as diabetic foot ulcer in patients with diabetes mellitus because of the clinical similarity of the 2 ailments. SCC of the toe is generally considered to have a low risk of metastasis. Locoregional or distant metastases without bone or tendon involvement are particularly rare. The authors report here an interesting case of rapidly spreading SCC of the toe with metastasis to multiple lymph nodes and cancer-related lymphedema. Physicians should be aware of the possibility of malignancy when they encounter chronic and recalcitrant ulcerative lesions of the digits.
authors.affiliation: Department of Dermatology, Hanyang University Hospital, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Park
authors.forename: Hyoung Il
authors.initials: HI
authors.lastname: Kwon
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Kim
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Young Suck
authors.initials: YS
authors.lastname: Ro
authors.forename: Joo Yeon
authors.initials: JY
authors.lastname: Ko
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D017719:Diabetic Foot / Q000175:diagnosis* / Q000473:pathology; D003951:Diagnostic Errors; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008209:Lymphedema / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D012878:Skin Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013997:Time Factors; D014034:Toes / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D002945:Cisplatin; D005472:Fluorouracil