title: Analgesic Efficacy and Safety of Curcuminoids in Clinical Practice: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
abstract: Curcuminoids are natural products with potent anti-inflammatory and antioxidant properties. There have been a number of reports on the analgesic effects of curcuminoids in clinical trials, yet data have not been fully conclusive.
  
  
  
  To provide the highest level of evidence on the efficacy of curcuminoids in patients with painful conditions through meta-analysis of data from randomized controlled trials (RCTs).
  
  
  
  A systematic review and meta-analysis was conducted using data reported by RCTs. The primary efficacy measure was pain intensity or algofunctional status. Treatment effect was summarized with standardized mean difference (SMD) calculated from differences in means of pain measures between treatment and control groups using a random-effects model.
  
  
  
  A total of eight RCTs met our inclusion criteria that included 606 randomized patients. Curcuminoids were found to significantly reduce pain (SMD: -0.57, 95% CI: -1.11 to -0.03, P = 0.04). This pain-relieving effect was found to be independent of administered dose and duration of treatment with curcuminoids, and was free from publication bias. Curcuminoids were safe and well tolerated in all evaluated RCTs.
  
  
  
  Curcuminoids supplements may be a safe and effective strategy to improve pain severity, by warranting further rigorously conducted studies to define the long-term efficacy and safety.
authors.affiliation: *Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; yhenrotin@ulg.ac.be sahebkara@mums.ac.ir amir_saheb2000@yahoo.com amirhossein.sahebkar@uwa.edu.au.
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.affiliation: Bone and Cartilage Research Unit, Arthropôle Liege, University of Liege, Liege, Begium; Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Vivalia, Marche-en-Famenne, Belgium yhenrotin@ulg.ac.be sahebkara@mums.ac.ir amir_saheb2000@yahoo.com amirhossein.sahebkar@uwa.edu.au.
authors.forename: Yves
authors.initials: Y
authors.lastname: Henrotin
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D003474:Curcumin / Q000627:therapeutic use*; D006801:Humans; D059408:Pain Management / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D003474:Curcumin
keywords: Curcumin; Curcuminoids; Effect Size; Meta-Analysis;  Pain