title: Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children.
abstract: OBJECTIVE
  Malnutrition continues to be a leading cause of stunted growth in many countries. This study aimed to investigate serum nesfatin-1 and orexin-A levels in underweight children and the potential correlations of these levels with anthropometric and nutritional parameters.
  
  
  METHODS
  The study enrolled 44 prepubertal children (between 2 and 12 years of age) with thinness grades of 1-3 and 41 healthy age- and gender-matched children. The demographic, clinical and laboratory parameters including nesfatin-1 and orexin-A concentrations were compared between the two groups. The correlations of nesfatin-1 and orexin-A with biochemical and anthropometric parameters were investigated. The receiver operating characteristic (ROC) analysis were also performed for evaluating nesfatin-1 and orexin-A in distinguishing children with malnutrition from healthy controls.
  
  
  RESULTS
  Thyroid-stimulating hormone, vitamin B12 and insulin levels were significantly lower in the study group than controls (p=0.001, p=0.049 and p=0.033, respectively). Mean nesfatin-1 levels in the malnourished group was also significantly lower compared to the healthy controls (3871.2 ± 1608.8 vs. 5515.0 ± 3816.4 pg/mL, p=0.012). No significant difference was observed in the orexin-A levels between the two groups (malnourished vs. control groups: 1135.7 ± 306.0 vs. 1025.7 ± 361.6 pg/mL, p=0.141). Correlation analyses revealed a positive correlation of nesfatin-1 and a negative correlation of orexin-A with body mass index (BMI) z-score. ROC analysis demonstrated that nesfatin-1 and orexin-A cannot be used to distinguish children with malnutrition from healthy controls (AUC: 0.620, p=0.061 for nesfatin-1 and AUC: 0.584, p=0.190 for orexin-A).
  
  
  CONCLUSIONS
  The positive correlation of nesfatin-1 and the negative correlation of orexin-A with BMI suggest that these neuropeptides may be a part of a protective mechanism in the maintenance of nutritional status and that they may have a role in regulating food intake in undernourished children.
authors.affiliation: Bezmialem Vakıf University Faculty of Medicine, Department of Pediatrics, İstanbul, Turkey Phone: +90 532 513 30 14 E-mail: feyzaustabas168@gmail.com.
authors.forename: Feyza
authors.initials: F
authors.lastname: Ustabaş Kahraman
authors.forename: Aysel
authors.initials: A
authors.lastname: Vehapoğlu
authors.forename: İlker Tolga
authors.initials: İT
authors.lastname: Özgen
authors.forename: Şule
authors.initials: Ş
authors.lastname: Terzioğlu
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Cesur
authors.forename: Ruşen
authors.initials: R
authors.lastname: Dündaröz
mesh_terms: D000886:Anthropometry / Q000379:methods; D001827:Body Height / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D015362:Child Nutrition Disorders / Q000097:blood* / Q000503:physiopathology; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D000068797:Orexins / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; D000068797:Orexins; D013972:Thyrotropin; D014805:Vitamin B 12; D013974:Thyroxine
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