title: Hyaluronan in adipose tissue: Beyond dermal filler and therapeutic carrier.
abstract: Adipose hyaluronan is increasingly recognized as an active player in adipose tissue fibrosis and metabolic dysfunction. However, this role poses as many challenges as opportunities for therapeutic targeting of adipose tissue dysfunction during nutrient oversupply.
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. LIFA Diabetes, Lilly Research Laboratories, Division of Eli Lilly and Company, Indianapolis, IN 46285, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Clair
authors.initials: C
authors.lastname: Crewe
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. philipp.scherer@utsouthwestern.edu.
authors.forename: Philipp E
authors.initials: PE
authors.lastname: Scherer
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000737:chemistry* / Q000503:physiopathology*; D050154:Adiposity; D000818:Animals; D003094:Collagen / Q000737:chemistry; D000067548:Dermal Fillers / Q000737:chemistry; D005109:Extracellular Matrix / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D000860:Hypoxia; D007107:Immune System; D009389:Neovascularization, Pathologic; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D011134:Polysaccharides / Q000737:chemistry; D011509:Proteoglycans / Q000737:chemistry
chemical_list: D054392:Adipokines; D000067548:Dermal Fillers; D011134:Polysaccharides; D011509:Proteoglycans; D006820:Hyaluronic Acid; D003094:Collagen; D006821:Hyaluronoglucosaminidase
references.citation: J Cell Biol. 1992 Aug;118(4):979-90
references.pmid: 1323568
references.citation: Pharm Res. 2004 Nov;21(11):2040-7
references.pmid: 15587926
references.citation: Diabetes Technol Ther. 2005 Dec;7(6):948-57
references.pmid: 16386101
references.citation: J Biol Chem. 2008 Mar 7;283(10):6530-45
references.pmid: 18174158
references.citation: Diabetes. 2010 Nov;59(11):2817-25
references.pmid: 20713683
references.citation: Physiol Rev. 2011 Jan;91(1):221-64
references.pmid: 21248167
references.citation: Semin Cutan Med Surg. 2012 Jun;31(2):78-87
references.pmid: 22640427
references.citation: Diabetes. 2013 Jun;62(6):1888-96
references.pmid: 23349492
references.citation: PLoS One. 2013;8(3):e58417
references.pmid: 23505504
references.citation: Cell Metab. 2013 Oct 1;18(4):470-7
references.pmid: 23954640
references.citation: Int J Obes (Lond). 2014 Aug;38(8):1035-43
references.pmid: 24173405
references.citation: Int J Med Sci. 2015 Jan 08;12(2):154-62
references.pmid: 25589892
references.citation: J Diabetes Res. 2015;2015:167283
references.pmid: 25834831
references.citation: Front Immunol. 2015 May 06;6:201
references.pmid: 25999946
references.citation: Diabetes. 2015 Nov;64(11):3713-24
references.pmid: 26293504
references.citation: Biochem Biophys Res Commun. 2015 Nov 27;467(4):623-8
references.pmid: 26525853
references.citation: Adv Drug Deliv Rev. 2016 Feb 1;97:186-203
references.pmid: 26541745