title: Bridging to lung transplantation for severe pulmonary hypertension using dual central Novalung lung assist devices.
abstract: This case describes the technique of using dual Novalungs (a pumpless extracorporeal system) to bridge a patient with idiopathic pulmonary hypertension to bilateral lung transplantation. A 41-year old lady with idiopathic pulmonary hypertension (with a possible veno-occlusive element) presented with symptoms of end-stage heart and lung failure. This was refractory to medical management with iloprost, sildenafil and bosentan. The patient was placed on the urgent waiting list for lung transplantation and central pulmonary artery to left atrial Novalung insertion was performed. Local anaesthetic was given before performing peripheral cardiopulmonary bypass due to the high risk of cardiac arrest. Two days later, donor organs became available and the patient was taken for double-lung transplantation. The pulmonary artery cannula was removed leaving a large defect. This was then closed using a bovine pericardial patch. Due to the damaged right superior pulmonary vein from Novalung cannulation, cardioplegia was given to facilitate an open atrial anastomosis. After 13 days in the intensive therapy unit, she was transferred to the ward. There were no further complications and she has been discharged home.
authors.affiliation: Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mayes
authors.affiliation: Freeman Hospital, Newcastle upon Tyne, UK.
authors.forename: Gunaratnam
authors.initials: G
authors.lastname: Niranjan
authors.affiliation: Newcastle University, Newcastle upon Tyne, UK Freeman Hospital, Newcastle upon Tyne, UK.
authors.forename: John
authors.initials: J
authors.lastname: Dark
authors.affiliation: Freeman Hospital, Newcastle upon Tyne, UK Northumbria University, Newcastle upon Tyne, UK stephen.clark@newcastle.ac.uk.
authors.forename: Stephen
authors.initials: S
authors.lastname: Clark
mesh_terms: D000328:Adult; D000818:Animals; D002417:Cattle; D004452:Echocardiography; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D065627:Familial Primary Pulmonary Hypertension / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006325:Heart Atria / Q000601:surgery*; D006801:Humans; D016040:Lung Transplantation; D011651:Pulmonary Artery / Q000601:surgery*; D011669:Pulmonary Wedge Pressure; D012720:Severity of Illness Index; D014850:Waiting Lists
keywords: Lung assist device; Lung transplantation
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