title: DHAP plus filgrastim as an effective peripheral stem cell mobilization regimen for autologous stem-cell transplantation in patients with relapsed/refractory lymphoma: A single center experience.
abstract: This study aimed to evaluate the efficiency of DHAP regimen plus filgrastim for mobilization of stem cells in patients with recurrent and/or refractory lymphoma. Thirty-four patients who took DHAP as salvage therapy prior to autologous stem cell transplantation were included. After chemotherapies, 2 cycles of DHAP plus filgrastim were administered to the patients. Stem cells from 32 patients (94%) were collected on median 11th day (8-12), and the median collected CD34(+) cell dose was 9.7 × 10(6)/kg (range 3.8-41.6). DHAP plus filgrastim was found to be an effective chemotherapy regimen in mobilizing CD34(+) stem cells into the peripheral.
authors.affiliation: Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey. Electronic address: drilhamiberber@hotmail.com.
authors.forename: Ilhami
authors.initials: I
authors.lastname: Berber
authors.affiliation: Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Erkurt
authors.affiliation: Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Irfan
authors.initials: I
authors.lastname: Kuku
authors.affiliation: Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Kaya
authors.affiliation: Department of Biostatistics and Medical Informatics, Inonu University School of Medicine, Malatya, Turkey.
authors.forename: Harika Gozukara
authors.initials: HG
authors.lastname: Bag
authors.affiliation: Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Nizam
authors.affiliation: Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Koroglu
authors.affiliation: Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozgul
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D000069585:Filgrastim / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D008297:Male; D012008:Recurrence; D014182:Transplantation, Autologous
chemical_list: D003561:Cytarabine; D003907:Dexamethasone; D000069585:Filgrastim; D002945:Cisplatin
keywords: DHAP plus filgrastim; Lymphoma; Stem cell mobilization