title: Phosphatidylethanolamine Metabolism in Health and Disease.
abstract: Phosphatidylethanolamine (PE) is the second most abundant glycerophospholipid in eukaryotic cells. The existence of four only partially redundant biochemical pathways that produce PE, highlights the importance of this essential phospholipid. The CDP-ethanolamine and phosphatidylserine decarboxylase pathways occur in different subcellular compartments and are the main sources of PE in cells. Mammalian development fails upon ablation of either pathway. Once made, PE has diverse cellular functions that include serving as a precursor for phosphatidylcholine and a substrate for important posttranslational modifications, influencing membrane topology, and promoting cell and organelle membrane fusion, oxidative phosphorylation, mitochondrial biogenesis, and autophagy. The importance of PE metabolism in mammalian health has recently emerged following its association with Alzheimer's disease, Parkinson's disease, nonalcoholic liver disease, and the virulence of certain pathogenic organisms.
authors.affiliation: Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Calzada
authors.affiliation: Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Ouma
authors.initials: O
authors.lastname: Onguka
authors.affiliation: Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Claypool
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D001343:Autophagy; D002175:Candida; D002262:Carboxy-Lyases / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003565:Cytidine Diphosphate / Q000031:analogs & derivatives / Q000378:metabolism; D004983:Ethanolamines / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008745:Methylation; D008928:Mitochondria / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism; D010085:Oxidative Phosphorylation; D010300:Parkinson Disease / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011328:Prions / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D014774:Virulence
chemical_list: D004983:Ethanolamines; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D011328:Prions; C006933:CDP ethanolamine; D003565:Cytidine Diphosphate; D002262:Carboxy-Lyases; C022353:phosphatidylserine decarboxylase
keywords: Alzheimer's disease; CDP-ethanolamine; Parkinson's disease; autophagy; mitochondria; phosphatidylethanolamine; phosphatidylserine decarboxylase
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