title: New Perspectives in the Chemistry of Marine Pyridoacridine Alkaloids.
abstract: Secondary metabolites from marine organisms are a rich source of novel leads for drug development. Among these natural products, polycyclic aromatic alkaloids of the pyridoacridine type have attracted the highest attention as lead compounds for the development of novel anti-cancer and anti-infective drugs. Numerous sophisticated total syntheses of pyridoacridine alkaloids have been worked out, and many of them have also been extended to the synthesis of libraries of analogues of the alkaloids. This review summarizes the progress in the chemistry of pyridoacridine alkaloids that was made in the last one-and-a-half decades.
authors.affiliation: Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5-13, 81377 Munich, Germany. loisl.plodek@cup.uni-muenchen.de.
authors.forename: Alois
authors.initials: A
authors.lastname: Plodek
authors.affiliation: Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5-13, 81377 Munich, Germany. franz.bracher@cup.uni-muenchen.de.
authors.forename: Franz
authors.initials: F
authors.lastname: Bracher
mesh_terms: D000166:Acridines / Q000302:isolation & purification / Q000494:pharmacology*; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D059001:Aquatic Organisms / Q000378:metabolism*; D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D010618:Phenanthrolines / Q000302:isolation & purification / Q000494:pharmacology*; D064210:Secondary Metabolism
chemical_list: D000166:Acridines; D000470:Alkaloids; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D010618:Phenanthrolines; C475900:pyridoacridine
keywords: marine alkaloids; pyridoacridines; total synthesis
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