title: Tandem Radical Fluoroalkylation-Cyclization: Synthesis of Tetrafluoro Imidazopyridines.
abstract: A copper-catalyzed fluoroalkylation-cyclization sequence of alkenes and alkynes enables the synthesis of fluorinated tetra- and dihydroimidazopyridines in moderate to excellent yields within 1 h at 70 °C. This reaction, which is carried out using copper(I) acetate as the catalyst, makes use of a new class of functionalized tetrafluoroethyl reagents based on a hypervalent iodine scaffold.
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich , Vladimir-Prelog-Weg 2, CH-8093 Zürich, Switzerland.
authors.forename: Julie
authors.initials: J
authors.lastname: Charpentier
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich , Vladimir-Prelog-Weg 2, CH-8093 Zürich, Switzerland.
authors.forename: Natalja
authors.initials: N
authors.lastname: Früh
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich , Vladimir-Prelog-Weg 2, CH-8093 Zürich, Switzerland.
authors.forename: Simon
authors.initials: S
authors.lastname: Foser
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich , Vladimir-Prelog-Weg 2, CH-8093 Zürich, Switzerland.
authors.forename: Antonio
authors.initials: A
authors.lastname: Togni