title: [The prediction of high-sensitivity C reactive protein for peripheral arterial sclerosis in middle-aged population].
abstract: OBJECTIVE
  To explore the predictive value of high-sensitivity C reactive protein (hsCRP) in middle-aged population during the peripheral arteriosclerosis.
  
  
  METHODS
  Random sampling method was used in the study. In 2006-2007 Kailuan Group health examination of 101,510 employees, using stratified random sampling method to select 5,852 as observational cohort included, in the final with a standard queue 5,440 in December 2009. This study selected to participate in the 2012-2013 health examination cohort as the research object, in accordance with the inclusion criteria ultimately selected survey 3,978, select the epidemiological investigation, physical examination, laboratory testing data analysis. Of the 3 978 subjects, 2,282 were male and 1,696 were female, and the baseline age was (53.80±11.14) years. According to the baseline hsCRP quartile level was divided into four groups for comparison of baseline data, using multiple linear regression analysis between hsCRP and brachial-ankle pulse wave velocity (baPWV). Area under the receiver operating characteristic (ROC) curve (AUC) was used to evaluate the prediction of hsCRP levels in peripheral arteriosclerosis.
  
  
  RESULTS
  With increase of hsCRP levels, the survey of baseline levels of baPWV showed increasing trend, (1,445.49±300.55), (1,494.46±307.94), (1,547.67±320.34), (1,621.32±342.53) cm/s, respectively. Multiple linear regression results showed that age, by logarithmic transformation of hsCRP (lghsCRP) level, systolic blood pressure and fasting blood glucose for each additional unit, baPWV levels were increased 266.47, 58.00, 5.02, 39.79 cm/s (P<0.001), and BMI for each additional unit, baPWV level decreased 9.52 cm/s (P=0.030). The prediction of hsCRP in peripheral artery showed that lghsCRP level of AUC to 0.59 (95% CI: 0.57-0.61), lower than the age and systolic blood pressure predicted value AUC (95% CI) of 0.69 (0.67-0.71), 0.75 (0.73-0.77), respectively.
  
  
  CONCLUSIONS
  The hsCRP level could not predict the peripheral arteriosclerosis alone, and the combined age and systolic blood pressure level could have better predictive value.
authors.affiliation: The Nephrology Department of Kailuan General Hospital, Tangshan 063000, China.
authors.forename: Jinhong
authors.initials: J
authors.lastname: Hou
authors.forename: Junjuan
authors.initials: J
authors.lastname: Li
authors.forename: Jianli
authors.initials: J
authors.lastname: Wang
authors.forename: Dejiang
authors.initials: D
authors.lastname: Lu
authors.forename: Ru
authors.initials: R
authors.lastname: Wang
authors.forename: Jinjie
authors.initials: J
authors.lastname: Huang
authors.forename: Chunhong
authors.initials: C
authors.lastname: Lu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Email: drwusl@163.com.
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
mesh_terms: D000842:Ankle; D055109:Ankle Brachial Index; D015415:Biomarkers; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002097:C-Reactive Protein; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease; D011673:Pulsatile Flow
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein