title: Fukushima simulation experiment: assessing the effects of chronic low-dose-rate internal 137Cs radiation exposure on litter size, sex ratio, and biokinetics in mice.
abstract: To investigate the transgenerational effects of chronic low-dose-rate internal radiation exposure after the Fukushima Daiichi Nuclear Power Plant accident in Japan, 18 generations of mice were maintained in a radioisotope facility, with free access to drinking water containing (137)CsCl (0 and 100 Bq/ml). The (137)Cs distribution in the organs of the mice was measured after long-term ad libitum intake of the (137)CsCl water. The litter size and the sex ratio of the group ingesting the (137)Cs water were compared with those of the control group, for all 18 generations of mice. No significant difference was noted in the litter size or the sex ratio between the mice in the control group and those in the group ingesting the (137)Cs water. The fixed internal exposure doses were ∼160 Bq/g and 80 Bq/g in the muscles and other organs, respectively.
authors.affiliation: Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, 2-2, B4, Yamada-Oka, Suita, Osaka 565-0871, Japan nakajima@radbio.med.osaka-u.ac.jp.
authors.forename: Hiroo
authors.initials: H
authors.lastname: Nakajima
authors.affiliation: Radioisotope Research Center, Osaka University, 2-4, B4, Yamada-Oka, Suita, Osaka 565-0871, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yamaguchi
authors.affiliation: Radioisotope Research Center, Osaka University, 2-4, B4, Yamada-Oka, Suita, Osaka 565-0871, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshimura
authors.affiliation: Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University.
authors.forename: Manabu
authors.initials: M
authors.lastname: Fukumoto
authors.affiliation: Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, 2-2, B4, Yamada-Oka, Suita, Osaka 565-0871, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Todo
mesh_terms: D000818:Animals; D002586:Cesium / Q000633:toxicity; D002588:Cesium Radioisotopes / Q000633:toxicity*; D002712:Chlorides / Q000633:toxicity; D005260:Female; D062406:Fukushima Nuclear Accident; D006801:Humans; D008098:Litter Size / Q000528:radiation effects*; D051379:Mice; D011829:Radiation Dosage; D011834:Radiation Monitoring; D012744:Sex Ratio
chemical_list: D002588:Cesium Radioisotopes; D002712:Chlorides; D002586:Cesium; C028019:cesium chloride
keywords: 137Cesium; Fukushima simulation experiment; chronic low-dose rate; internal radiation exposure; mice; transgenerational effects
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