title: Untreated newly diagnosed essential hypertension is associated with nonalcoholic fatty liver disease in a population of a hypertensive center.
abstract: OBJECTIVE
  Recent studies have demonstrated that hypertension (HTN) is associated with nonalcoholic fatty liver disease (NAFLD) in treated hypertensive patients. The aim of this study was to investigate the association between newly diagnosed essential HTN and NAFLD in untreated hypertensive patients.
  
  
  METHODS
  A consecutive series of 240 subjects (143 hypertensives and 97 normotensives), aged 30-80 years, without diabetes mellitus were enrolled in the study. Subjects with 24-hour systolic blood pressure (SBP) values ≥130 mmHg and/or diastolic BP values ≥80 mmHg were defined as hypertensives. NAFLD was defined as the presence of liver hyperechogenicity on ultrasound.
  
  
  RESULTS
  Body mass index (P=0.002) and essential HTN (P=0.016) were independently associated with NAFLD in the multivariate logistic regression model. Furthermore, the multivariate analysis revealed that morning SBP (P=0.044) was independently associated with NAFLD.
  
  
  CONCLUSIONS
  Untreated, newly diagnosed essential HTN is independently associated with NAFLD. Ambulatory BP monitoring could be used for the diagnosis of essential HTN in patients with NAFLD.
authors.affiliation: Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Spyros
authors.initials: S
authors.lastname: Michopoulos
authors.affiliation: Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Vasiliki I
authors.initials: VI
authors.lastname: Chouzouri
authors.affiliation: Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Efstathios D
authors.initials: ED
authors.lastname: Manios
authors.affiliation: Nephrology Department, Medical School of Athens, Aretaieio Hospital, Athens, Greece.
authors.forename: Eirini
authors.initials: E
authors.lastname: Grapsa
authors.affiliation: Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Zoi
authors.initials: Z
authors.lastname: Antoniou
authors.affiliation: Oncology Department, Medical School of Athens, Aretaieio Hospital, Athens, Greece.
authors.forename: Christos A
authors.initials: CA
authors.lastname: Papadimitriou
authors.affiliation: Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zakopoulos
authors.affiliation: Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Athanasios-Meletios
authors.initials: AM
authors.lastname: Dimopoulos
keywords: ambulatory blood pressure; body mass index; hypertension; liver steatosis; nonalcoholic fatty liver disease
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