title: Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity.
abstract: Enterovirus 71 (EV71) is one of the causative agents of hand, foot, and mouth disease (HFMD), which sometimes leads to severe neurological disease and death in the Asia-Pacific region. In Chinese medicine, HFMD is caused mainly by an accumulation of damp-heat and toxicity in the body. No effective drugs are currently available for the treatment and prevention of EV71 infection. This review summarizes the potential Chinese herbal extracts and isolated compounds with antiviral activity against EV71 and their clinical applications, especially those categorized as heat-clearing and detoxifying.
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China ; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203 China.
authors.forename: Mengjie
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China ; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203 China ; Xinxiang Medical University, Jinsui Road 601, Xinxiang, Henan 453003 China.
authors.forename: Ling
authors.initials: L
authors.lastname: Tao
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China ; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203 China.
authors.forename: Hongxi
authors.initials: H
authors.lastname: Xu
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