title: A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia.
abstract: We performed a meta-analysis of randomized controlled trials comparing low-molecular-weight heparin (LMWH) vs no LMWH in women with inherited thrombophilia and prior late (≥10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared with no LMWH (relative risk, 0.81; 95% confidence interval, 0.55-1.19;P= .28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia.
authors.affiliation: The Ottawa Blood Disease Centre, Division of Hematology and Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada;
authors.forename: Leslie
authors.identifier: http://orcid.org/0000-0002-5587-398X
authors.initials: L
authors.lastname: Skeith
authors.affiliation: The Ottawa Blood Disease Centre, Division of Hematology and Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada;
authors.forename: Marc
authors.initials: M
authors.lastname: Carrier
authors.affiliation: Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland;
authors.forename: Risto
authors.initials: R
authors.lastname: Kaaja
authors.affiliation: A. Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy;
authors.forename: Ida
authors.identifier: http://orcid.org/0000-0001-9218-3622
authors.initials: I
authors.lastname: Martinelli
authors.affiliation: Clinical Trial Centre, University of Leipzig, Leipzig, Germany;
authors.forename: David
authors.identifier: http://orcid.org/0000-0002-6916-1465
authors.initials: D
authors.lastname: Petroff
authors.affiliation: Department of Obstetrics and Gynecology, Friedrich Schiller University Hospital, Jena, Germany;
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Schleußner
authors.affiliation: LifeQuest Centre for Reproductive Medicine, Toronto, ON, Canada; Department of Medicine and Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada; and.
authors.forename: Carl A
authors.identifier: http://orcid.org/0000-0002-9036-6326
authors.initials: CA
authors.lastname: Laskin
authors.affiliation: The Ottawa Blood Disease Centre, Division of Hematology and Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Obstetrics and Gynecology, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada.
authors.forename: Marc A
authors.identifier: http://orcid.org/0000-0001-8166-3487
authors.initials: MA
authors.lastname: Rodger
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000517:prevention & control*; D000328:Adult; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy* / Q000453:epidemiology; D019851:Thrombophilia / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D006495:Heparin, Low-Molecular-Weight