title: Impairment of thiol-disulfide homeostasis in preeclampsia.
abstract: OBJECTIVE
  To investigate the effects of severity of preeclampsia on thiol-disulfide homeostasis (TDH).
  
  
  METHODS
  A total of 108 participants were divided into three groups: Group 1 was composed of pregnant women with no obstetric complications, Group 2 included pregnant women with mild preeclampsia, and Group 3 consisted of pregnant women with severe preeclampsia. TDH parameters were determined, and comparisons of clinical and routine laboratory test findings were made in all groups.
  
  
  RESULTS
  The serum native thiol level was 347.9 ± 27.4 in the control group, 237.2 ± 44.2 in the mild preeclampsia group, and 227.9 ± 53.1 in the severe preeclampsia group (p < 0.001). The serum total thiol level was 376.1 ± 31.9 in the control group, 261.8 ± 49.4 in the mild preeclampsia group, and 248.3 ± 57.4 in the severe preeclampsia group (p < 0.001). The disulfide level was 14.1 ± 5.6 in the control group, 12.3 ± 5.1 in the mild preeclampsia group, and 10.2 ± 4.8 in the severe preeclampsia group (p = 0.001). A significant correlation between impairment in degree of TDH and severity of preeclampsia was observed.
  
  
  CONCLUSIONS
  TDH was impaired in women with preeclampsia, and this impairment increased with disease severity. Therefore, impaired TDH may have a role in the etiopathogenesis of the disease.
authors.affiliation: a Department of Obstetrics and Gynecology , Ankara Training and Research Hospital , Ankara , Turkey .
authors.forename: Vakkas
authors.initials: V
authors.lastname: Korkmaz
authors.affiliation: a Department of Obstetrics and Gynecology , Ankara Training and Research Hospital , Ankara , Turkey .
authors.forename: Zehra
authors.initials: Z
authors.lastname: Kurdoglu
authors.affiliation: b Department of Biochemistry , Yildirim Beyazit University , Ankara , Turkey .
authors.forename: Murat
authors.initials: M
authors.lastname: Alisik
authors.affiliation: c Department of Obstetrics and Gynecology , Yuzuncu Yil University , Van , Turkey .
authors.forename: Orkun
authors.initials: O
authors.lastname: Cetin
authors.affiliation: d Department of Physiology , Hacettepe University , Ankara , Turkey , and.
authors.forename: Hilal
authors.initials: H
authors.lastname: Korkmaz
authors.affiliation: e Department of Biochemistry , Ankara Training and Research Hospital , Ankara , Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Surer
authors.affiliation: b Department of Biochemistry , Yildirim Beyazit University , Ankara , Turkey .
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D004220:Disulfides / Q000097:blood*; D005260:Female; D006706:Homeostasis; D006801:Humans; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism; D011247:Pregnancy; D012720:Severity of Illness Index; D013438:Sulfhydryl Compounds / Q000097:blood*; D055815:Young Adult
chemical_list: D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Disulfide; preeclampsia; thiol