title: PIM1 kinase as a promise of targeted therapy in prostate cancer stem cells.
abstract: Since the last decade, the PIM family serine/threonine kinases have become a focus in cancer research. Numerous clinical data supports that overexpression of PIM1 is associated with tumor formation in various tissues. However, little is known regarding the function of PIM1 in cancer stem cells. In cancer cells, PIM1 has essential roles in the regulation of the cell cycle, cell proliferation, cell survival and multiple drug resistance. In stem cells, PIM1 kinase exhibits a significant function in stem cell proliferation, self-renewal and expansion. Thus, PIM1 shows a great promise in cancer therapy by targeting stem cells. Furthermore, it is imperative to investigate Pim-1 targeting in cancer stem cells by applicable inhibitors for improving future outcomes. The present review investigated the potential of PIM1 as a therapy target in prostate cancer stem cells.
authors.affiliation: Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.
authors.forename: Yingqiu
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.
authors.forename: Samat
authors.initials: S
authors.lastname: Bayakhmetov
keywords: PIM1; cancer stem cell; prostate cancer
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