title: The relationship between hippocampal volume and static postural sway: results from the GAIT study.
abstract: The role of the hippocampus in postural control, in particular in maintaining upright stance, has not been fully examined in normal aging. This study aims to examine the association of postural sway with hippocampal volume while maintaining upright stance in healthy older individuals. Seventy healthy individuals (mean age 69.7 ± 3.4 years; 41.4 % women) were recruited in this study based on cross-sectional design. Hippocampal volume (quantified from a three-dimensional T1-weighted MRI using semi-automated software), three center of pressure (COP) motion parameters (sway area, path length of anterior-posterior (AP) and medial-lateral (ML) displacement) while maintaining upright stance (eyes open and closed), and the relative difference between open and closed eye conditions were used as outcome measures. Age, sex, body mass index, lower limb proprioception, distance vision, 15-item geriatric depression scale score, total cranial volume, and white matter abnormalities were used as covariates. The sway area decreased from open to closed eye condition but this variation was non-significant (P = 0.244), whereas path length of AP and ML displacement increased significantly (P < 0.003). Increase in sway area from open to closed eyes was associated with greater hippocampal volume (β -18.21; P = 0.044), and a trend for an association of increase in path length of AP displacement (P = 0.075 for open eyes and P = 0.071 for closed eyes) with greater hippocampal volume was reported. The hippocampus is involved in upright postural control in normal aging, such that an increase in sway area of COP motion from open to closed eyes is associated with greater hippocampal volume in healthy older adults.
authors.affiliation: Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis - Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada. olivier.beauchet@mcgill.ca.|Dr. Joseph Kaufmann Chair in Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada. olivier.beauchet@mcgill.ca.|Centre of Excellence on Aging and Chronic Diseases of McGill integrated University Health Network, Quebec, Canada. olivier.beauchet@mcgill.ca.
authors.forename: Olivier
authors.initials: O
authors.lastname: Beauchet
authors.affiliation: Neuromechanical Research Centre, Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Barden
authors.affiliation: Aging, Mobility and Cognitive Neuroscience Laboratory, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Teresa
authors.initials: T
authors.lastname: Liu-Ambrose
authors.affiliation: Andrew and Marjorie McCain Human Performance Laboratory, Richard J. Currie Center, Faculty of Kinesiology, University of New Brunswick, Fredericton, NB, Canada.
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Chester
authors.affiliation: Department of Physical Therapy, College of Rehabilitation Sciences, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Tony
authors.initials: T
authors.lastname: Szturm
authors.affiliation: Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland.
authors.forename: Gilles
authors.initials: G
authors.lastname: Allali
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D005684:Gait / Q000502:physiology*; D006624:Hippocampus / Q000033:anatomy & histology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D004856:Postural Balance / Q000502:physiology*; D011434:Proprioception / Q000502:physiology*; D012016:Reference Values
keywords: Hippocampus; Magnetic resonance imaging; Motor control; Older adults; Postural sway; Posture
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