title: Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China.
abstract: OBJECTIVE
  To detect the interactions between six functional polymorphisms in ABCA1 and obesity in Kazakhs with low HDL-C levels.
  
  
  METHODS
  A total of 204 patients with low HDL-C and 207 health control subjects, which were randomly selected from among 5692 adult Kazakhs, were matched for age and sex. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806, rs1800976, and rs4149313.
  
  
  RESULTS
  (1) The genotypic and allelic frequencies of rs2515602, rs2230806 and rs4149313 were different between normal HDL-C and low HDL-C subjects, the genotypic frequency of rs2275542 was also different between normal HDL-C and low HDL-C subjects (p < 0.05); (2) the level of HDL-C (rs2515602 and rs2275542) in normal HDL-C subjects were different among the genotypes (p < 0.05); the levels of TC, LDL-C (rs2515602, rs4149313); TG (rs2515602, rs1800976, rs4149313) in low HDL-C patients were different among the genotypes (p < 0.05); (3) interactions between the rs3890182, rs2275542, rs180096, and rs4149313 polymorphisms in ABCA1 gene and obesity may be associated with low HDL-C disease; (4) the C-C-C-A-A-G, T-C-C-A-A-A, T-C-C-A-A-G, C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes were significant between the subjects with normal HDL-C and low HDL-C level (p < 0.05).
  
  
  CONCLUSIONS
  The differences in serum lipid levels between normal HDL-C and low HDL-C subjects among Kazakhs might partly result from ABCA1 gene polymorphisms; ABCA1 gene polymorphisms may be associated with low HDL-C disease; the low HDL-C disease might partly result from interactions between ABCA1 gene polymorphisms and obesity; the C-C-C-A-A-G, T-C-C-A-A-A, and T-C-C-A-A-G haplotypes may serve as risk factors of low HDL-C disease among Kazakhs, the C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes may serve as protective factor of low HDL-C disease among Kazakhs.
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. ymhldjxa@sina.com.
authors.forename: Ming-hong
authors.initials: MH
authors.lastname: Yao
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. guoheng@shzu.edu.cn.
authors.forename: Heng
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. hejia123.shihezi@163.com.
authors.forename: Jia
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. erniu19880215@sina.com.
authors.forename: Yi-zhong
authors.initials: YZ
authors.lastname: Yan
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. marulin@126.com.
authors.forename: Ru-lin
authors.initials: RL
authors.lastname: Ma
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. 13399931625@163.com.
authors.forename: Yu-song
authors.initials: YS
authors.lastname: Ding
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. yfyxxzjy@126.com.
authors.forename: Jing-yu
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. liujiaming@shzu.edu.cn.
authors.forename: Jia-ming
authors.initials: JM
authors.lastname: Liu
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. zmberry@foxmail.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. lishugang@ymail.com.
authors.forename: Shu-gang
authors.initials: SG
authors.lastname: Li
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. yfyxxxsz@sina.com.
authors.forename: Shang-zhi
authors.initials: SZ
authors.lastname: Xu
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. niuqiang1214@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Niu
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. jiaojiaolong881202@163.com.
authors.forename: Jiao-long
authors.initials: JL
authors.lastname: Ma
authors.affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China. pge888@sina.com.
authors.forename: Shu-xia
authors.initials: SX
authors.lastname: Guo
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000235:genetics*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002681:China; D008076:Cholesterol, HDL / Q000097:blood / Q000172:deficiency; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D052456:Hypoalphalipoproteinemias / Q000097:blood / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D015415:Biomarkers; D008076:Cholesterol, HDL; D005819:Genetic Markers
keywords: ABCA1; Kazakh; interaction; low HDL-C; obesity
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