title: Adventitial ablation technique that permits the assessment of adventitial-dependent contribution to microvascular contractile function.
abstract: Resistance arteries have been implicated as a major contributing factor in the sequela of disease conditions such as hypertension and diabetes and, as such, are a major focus of cardiovascular research. The paracrine influence of the intimal endothelial layer of resistance arteries is well established. Considering the growing body of evidence substantiating a functionally relevant vascular adventitia, in this study we have established a technique that permits determination of the functional influence of the adventitial layer on resistance artery tone. Isolating adventitial-dependent function, analogous to isolating endothelial function, has potentially significant implications for studying the as yet unexplored role of the microvascular adventitial layer in modulating acute vascular contractile function.
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, Scotland, UK.
authors.forename: Satirah
authors.initials: S
authors.lastname: Zainalabidin
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, Scotland, UK.
authors.forename: Roger M
authors.initials: RM
authors.lastname: Wadsworth
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, Scotland, UK. Electronic address: paul.coats@strath.ac.uk.
authors.forename: Paul
authors.initials: P
authors.lastname: Coats
mesh_terms: D055011:Ablation Techniques; D063194:Adventitia / Q000502:physiology* / Q000601:surgery*; D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology / Q000601:surgery; D008297:Male; D008833:Microcirculation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014661:Vasoconstriction
keywords: Adventitia; Microcirculation; Pressure autoregulation; Vasoconstriction; Vasorelaxation