title: MALDI Matrix Research for Biopolymers.
abstract: Matrices are necessary materials for ionizing analytes in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). The choice of a matrix appropriate for each analyte controls the analyses. Thus, in some cases, development or improvement of matrices can become a tool for solving problems. This paper reviews MALDI matrix research that the author has conducted in the recent decade. It describes glycopeptide, carbohydrate, or phosphopeptide analyses using 2,5-dihydroxybenzoic acid (2,5-DHB), 1,1,3,3-tetramethylguanidinium (TMG) salts of p-coumaric acid (CA) (G3CA), 3-aminoquinoline (3-AQ)/α-cyano-4-hydroxycinnamic acid (CHCA) (3-AQ/CHCA) or 3-AQ/CA and gengeral peptide, peptide containing disulfide bonds or hydrophobic peptide analyses using butylamine salt of CHCA (CHCAB), 1,5-diaminonaphthalene (1,5-DAN), octyl 2,5-dihydroxybenzoate (alkylated dihydroxybenzoate, ADHB), or 1-(2,4,6-trihydroxyphenyl)octan-1-one (alkylated trihydroxyacetophenone, ATHAP).
authors.affiliation: Koichi Tanaka Mass Spectrometry Research Laboratory, Shimadzu Corporation.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Fukuyama
keywords: MALDI-MS; biopolymers; matrix
references.citation: J Am Soc Mass Spectrom. 2007 Apr;18(4):693-7
references.pmid: 17223354
references.citation: Anal Chem. 2014 Feb 18;86(4):1937-42
references.pmid: 24498852
references.citation: Anal Chem. 2012 Jul 17;84(14):6097-103
references.pmid: 22725700
references.citation: Rapid Commun Mass Spectrom. 1989 Dec;3(12):432-5
references.pmid: 2520223
references.citation: Anal Chem. 2007 Feb 15;79(4):1604-10
references.pmid: 17297962
references.citation: J Am Soc Mass Spectrom. 1998 Feb;9(2):166-74
references.pmid: 9679596
references.citation: Anal Chem. 2012 Aug 21;84(16):7146-51
references.pmid: 22830976
references.citation: Anal Bioanal Chem. 2006 Sep;386(1):24-37
references.pmid: 16830111
references.citation: J Mass Spectrom. 2006 Feb;41(2):191-201
references.pmid: 16382486
references.citation: Anal Chem. 2004 Sep 1;76(17):5109-17
references.pmid: 15373450
references.citation: Rapid Commun Mass Spectrom. 2012 Oct 30;26(20):2454-60
references.pmid: 22976212
references.citation: Rapid Commun Mass Spectrom. 1989 Dec;3(12):436-9
references.pmid: 2520224
references.citation: Rapid Commun Mass Spectrom. 2014 Mar 30;28(6):662-4
references.pmid: 24519829
references.citation: Anal Chem. 2013 Oct 15;85(20):9444-8
references.pmid: 24063356
references.citation: Anal Chem. 2008 Mar 15;80(6):2171-9
references.pmid: 18275166
references.citation: Rapid Commun Mass Spectrom. 2012 Mar 30;26(6):693-700
references.pmid: 22328224
references.citation: Mass Spectrom Rev. 2002 May-Jun;21(3):183-216
references.pmid: 12476442
references.citation: Anal Chem. 2006 Mar 15;78(6):1774-9
references.pmid: 16536411
references.citation: Rapid Commun Mass Spectrom. 1996;10(8):923-6
references.pmid: 8777326
references.citation: Anal Chem. 2011 May 15;83(10):3663-7
references.pmid: 21506551
references.citation: Anal Chem. 1988 Oct 15;60(20):2299-301
references.pmid: 3239801
references.citation: Rapid Commun Mass Spectrom. 2006;20(11):1761-8
references.pmid: 16676301
references.citation: Anal Chem. 2012 May 1;84(9):4237-43
references.pmid: 22506777
references.citation: Anal Chem. 2001 Aug 1;73(15):3679-86
references.pmid: 11510834
references.citation: Anal Chem. 2004 May 15;76(10):2938-50
references.pmid: 15144208
references.citation: Science. 1989 Oct 6;246(4926):64-71
references.pmid: 2675315
references.citation: Anal Chem. 2012 Nov 6;84(21):9453-61
references.pmid: 23072501
references.citation: Anal Chem. 2003 May 15;75(10):2362-9
references.pmid: 12918978
references.citation: Anal Chem. 2010 Jan 1;82(1):44-8
references.pmid: 19919047