title: Predictive factors of small bowel patency in Crohn's disease patients.
abstract: BACKGROUND
  Patency capsule was developed to avoid small bowel video capsule endoscopy retention, namely in patients with Crohn's disease.
  
  
  OBJECTIVE
  To evaluate the predictive factors of small bowel patency in Crohn's disease patients.
  
  
  METHODS
  Retrospective analysis including 151 Crohn's disease patients submitted to patency capsule (Agile® Patency Capsule) from 2011 to 2012. Patients that excreted the intact patency capsule were classified as having a patent small bowel (without patency capsule retention), other patients were considered to have negative patency of the small bowel (patency capsule retention).
  
  
  RESULTS
  Patients had a mean age of 41±14 years, 54% were female and 25% had been previously submitted to surgery. Stricturing disease was seen in 20% of cases and penetrating disease in 16% of cases. Left-sided colonic lesions and ileal strictures were observed at colonoscopy in 13% and 9% of patients, respectively. In our sample, 28% of patients had negative patency of the small bowel (patency capsule retention). In multivariate analysis, independent factors that were associated with negative patency of the small bowel in Crohn's disease patients were stricturing (OR 10.16, p < 0.001) and penetrating phenotypes (OR 11.73, p = 0.001), left-sided colonic lesions (OR 3.77, p = 0.038), ileal stricture (OR 9.76, p = 0.003); previous intestinal surgery was found to be protective (OR 0.16, p = 0.006).
  
  
  CONCLUSIONS
  Stricturing or penetrating disease, ileal strictures, no previous surgery and left-sided colonic lesions were the factors associated with negative small bowel patency in Crohn's disease patients.
authors.affiliation: Gastroenterology, Centro Hospitalar São João, Portugal.
authors.forename: Andreia
authors.initials: A
authors.lastname: Albuquerque
authors.affiliation: Gastroenterology, Centro Hospitalar São João, Portugal.
authors.forename: Hélder
authors.initials: H
authors.lastname: Cardoso
authors.affiliation: Gastroenterology, Centro Hospitalar São João, Portugal.
authors.forename: Margarida
authors.initials: M
authors.lastname: Marques
authors.affiliation: Gastroenterology, Centro Hospitalar São João, Portugal.
authors.forename: Susana
authors.initials: S
authors.lastname: Rodrigues
authors.affiliation: Gastroenterology, Centro Hospitalar S. João, Portugal.
authors.forename: Filipe
authors.initials: F
authors.lastname: Vilas-Boas
authors.affiliation: Gastroenterology, Centro Hospitalar S. João, Portugal.
authors.forename: Susana
authors.initials: S
authors.lastname: Lopes
authors.affiliation: Health Information and Decision Sciences, University of Porto, Portugal.
authors.forename: Cláudia Camila
authors.initials: CC
authors.lastname: Dias
authors.affiliation: Gastroenterology, Centro Hospitalar S. João, Portugal.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Macedo
mesh_terms: D000328:Adult; D053705:Capsule Endoscopes; D053704:Capsule Endoscopy / Q000295:instrumentation; D003424:Crohn Disease / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology* / Q000473:pathology; D007421:Intestine, Small / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors