title: Association between the change in body mass index from early adulthood to midlife and subsequent type 2 diabetes mellitus.
abstract: OBJECTIVE
  To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife.
  
  
  METHODS
  This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and measured height were available. BMI at 20 and 40 years and BMI change in between were defined as early-adulthood BMI, midlife BMI, and early-adulthood BMI change.
  
  
  RESULTS
  The odds ratio (OR) for T2DM associated with an 1-unit increment of early-adulthood or midlife BMI was 1.08 (95% confidence interval (CI), 1.07-1.08) and 1.09 (95% CI, 1.09-1.10) respectively. In the cross-tabulation of both early-adulthood BMI and BMI change, the prevalence of T2DM increased across both variables. Compared with participants with normal early-adulthood weight and BMI increase/decrease ≤1, the OR (95% CI) for T2DM of participants with early-adulthood overweight/obesity and BMI increase ≥4 kg/m(2) was 3.49 (3.05-4.00). For participants with early-adulthood underweight and BMI increase/decrease ≤ 1, the OR (95% CI) was 0.85 (0.75-0.97). Subgroup analysis according to sex and age showed similar trends.
  
  
  CONCLUSIONS
  Early-adulthood BMI may influence T2DM prevalence after midlife independent of current BMI. T2DM prevalence after midlife was positively associated with early-adulthood weight gain and inversely related to early-adulthood weight loss, while early-adulthood weight loss could not completely negate the adverse effect of early-adulthood overweight/obesity on diabetes.
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Wanwan
authors.initials: W
authors.lastname: Sun
authors.affiliation: Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Shi
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Mu
authors.affiliation: Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Lulu
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authors.lastname: Chen
authors.affiliation: The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.affiliation: The Affiliated Hospital of Luzhou Medical College, Luzhou, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wan
authors.affiliation: Karamay Municipal People's Hospital, Xinjiang, China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Wu
authors.affiliation: The First Hospital of Jilin University, Changchun, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: The First Hospital of Jilin University, Changchun, China.
authors.forename: Guixia
authors.initials: G
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Zuojie
authors.initials: Z
authors.lastname: Luo
authors.affiliation: The First Hospital of Lanzhou University, Lanzhou, China.
authors.forename: Xulei
authors.initials: X
authors.lastname: Tang
authors.affiliation: Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Jiangxi People's Hospital, Nanchang, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Huo
authors.affiliation: Dalian Municipal Central Hospital, Dalian, China.
authors.forename: Zhengnan
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Su
authors.affiliation: The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Youmin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Guijun
authors.initials: G
authors.lastname: Qin
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Huacong
authors.initials: H
authors.lastname: Deng
authors.affiliation: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yu
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Feixia
authors.initials: F
authors.lastname: Shen
authors.affiliation: Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Liebin
authors.initials: L
authors.lastname: Zhao
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Laboratory of Endocrine and Metabolic Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jichao
authors.initials: J
authors.lastname: Sun
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ding
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Dai
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Tiange
authors.initials: T
authors.lastname: Wang
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jieli
authors.initials: J
authors.lastname: Lu
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yufang
authors.initials: Y
authors.lastname: Bi
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Shenghan
authors.initials: S
authors.lastname: Lai
authors.affiliation: Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Donghui
authors.initials: D
authors.lastname: Li
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
authors.affiliation: National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Laboratory of Endocrine and Metabolic Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D015984:Causality; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D013851:Thinness / Q000453:epidemiology; D015430:Weight Gain