title: Autism and Cancer Share Risk Genes, Pathways, and Drug Targets.
abstract: Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of autism(s) and cancer(s), with a focus on mechanistic pathways, could lead to repurposed therapeutics.
authors.affiliation: MIND Institute, School of Medicine, University of California Davis, Sacramento, CA 95817, USA; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA 95817, USA. Electronic address: crawley@ucdavis.edu.
authors.forename: Jacqueline N
authors.initials: JN
authors.lastname: Crawley
authors.affiliation: Department of Microbiology and Molecular Genetics, University of California Davis, Davis, CA 95616, USA; Comprehensive Cancer Center, University of California Davis, Sacramento, CA, 95817, USA.
authors.forename: Wolf-Dietrich
authors.initials: WD
authors.lastname: Heyer
authors.affiliation: MIND Institute, School of Medicine, University of California Davis, Sacramento, CA 95817, USA; Comprehensive Cancer Center, University of California Davis, Sacramento, CA, 95817, USA; Department of Medical Microbiology and Immunology and Genome Center, University of California Davis, Davis, CA 95616, USA.
authors.forename: Janine M
authors.initials: JM
authors.lastname: LaSalle
mesh_terms: D001321:Autistic Disorder / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*
keywords: DNA repair; autism; cancer; chromatin remodeling; gene; signaling pathway
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