title: Mosquito gut antiparasitic and antiviral immunity.
abstract: Mosquitoes are responsible for the transmission of diseases with a serious impact on global human health, such as malaria and dengue. All mosquito-transmitted pathogens complete part of their life cycle in the insect gut, where they are exposed to mosquito-encoded barriers and active factors that can limit their development. Here we present the current understanding of mosquito gut immunity against malaria parasites, filarial worms, and viruses such as dengue, Chikungunya, and West Nile. The most recently proposed immune mediators involved in intestinal defenses are discussed, as well as the synergies identified between the recognition of gut microbiota and the mounting of the immune response.
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Raúl G
authors.initials: RG
authors.lastname: Saraiva
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Seokyoung
authors.initials: S
authors.lastname: Kang
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Simões
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Yesseinia I
authors.initials: YI
authors.lastname: Angleró-Rodríguez
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: gdimopo1@jhu.edu.
authors.forename: George
authors.initials: G
authors.lastname: Dimopoulos
mesh_terms: D000818:Animals; D009033:Culicidae / Q000276:immunology*; D018562:Disease Transmission, Infectious / Q000517:prevention & control; D005368:Filariasis / Q000276:immunology*; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D007422:Intestines / Q000276:immunology* / Q000382:microbiology; D008018:Life Cycle Stages; D064307:Microbiota; D000072138:Mosquito Vectors; D010273:Parasitic Diseases, Animal / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
keywords: Dengue; Innate immunity; Microbiota; Mosquito; Plasmodium