title: Copper-catalyzed oxidative [2+2+1] annulation of 1,n-enynes with α-carbonyl alkyl bromides through C-Br/C-H functionalization.
abstract: The Cu-catalyzed oxidative [2+2+1] annulation of 1,n-enynes (n = 6, 7) with α-carbonyl alkyl bromides through C-Br/C-H functionalization has been developed. Using Ag2CO3/tert-butyl hydroperoxide (TBHP) as co-oxidants, α-carbonyl alkyl bromides provide two bonds, the α-C(sp(3))-Br bonds and the α-C(sp(3))-H bonds, to cyclize with the 1,n-enynes and Cu(MeCN)4PF6, thus forming three new C-C bonds and two rings in a single reaction.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. srj0731@hnu.edu.cn jhli@hnu.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. srj0731@hnu.edu.cn jhli@hnu.edu.cn.
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Song
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. srj0731@hnu.edu.cn jhli@hnu.edu.cn.
authors.forename: Xuan-Hui
authors.initials: XH
authors.lastname: Ouyang
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. srj0731@hnu.edu.cn jhli@hnu.edu.cn.
authors.forename: Fang-Lin
authors.initials: FL
authors.lastname: Tan
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. srj0731@hnu.edu.cn jhli@hnu.edu.cn.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. srj0731@hnu.edu.cn jhli@hnu.edu.cn and State Key Laboratory of Applied Organic Chemistry Lanzhou University, Lanzhou 730000, China.
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li