title: Limits of application of initiated chemiluminescence in monitoring of oncological process of mucous membrane of mouth and larynx.
abstract: Investigation into the limits of application of chemiluminescence (CL) methods in oncology still attracts the attention of researchers. In the present work we analyze the screening and monitoring of oncological processes (OP) in the mucous membrane of the mouth and larynx by initiated CL (ICL). Chemiluminescence has already been used by stomatologists to define the start of OP, but methods that reflect the metabolic changes in organism under cancer diagnostics still have not found their place. This work presents results of ICL on blood serum (BS) of patients with oncological diseases at different stages of medical treatment compared with those of healthy people. We found an essential metabolic difference only in types of OP that are characterized by two maxima on chemiluminograms. These OP represent only 12.81% of groups of patients with oncological diseases. The possibility to apply ICL methods to monitor operation quality and control medical treatment at different stages when the two ICL maxima are present is established. At present, the chemiluminograms with the two maxima are mostly informative, but this does not exclude the quantitative analysis of other ICL kinetic methods and is encouraging for their investigation. Any OP introduces changes in organism function and these should be reflected in the ICL. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Lviv Medical Institute, Lviv Polytechnic National University, Ukraine.
authors.forename: Iryna
authors.identifier: http://orcid.org/0000-0003-2487-1022
authors.initials: I
authors.lastname: Oliynyk
mesh_terms: D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D049449:Luminescence; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000473:pathology*; D009092:Mucous Membrane / Q000473:pathology*
keywords: blood serum; chemiluminescence; oral cancer; second maximum