title: Studying DEHP migration in plasticized PVC used for blood bags by coupling Raman confocal microscopy to UV spectroscopy.
abstract: Plasticized PVC is widely used to make medical devices such as tubing, perfusion bags and blood bags. By using confocal Raman microscopy on a PVC sheet plasticized with around 40% of di-(2-ethylhexyl)phthalate (DEHP), we propose a simple and sensitive approach to studying and understanding the diffusion of plasticizers from polymers into the surrounding media. Moreover, we sought to correlate our findings to standard measurements conducted by UV spectroscopy. This study showed differences in the concentration gradient observed due to the diffusion of the plasticizer inside a PVC sheet. We can thus follow the critical DEHP ratios that can impact the diffusion process. Water and ethanol were chosen as storage media: in ethanol, the lowest concentration of DEHP was observed at the surface resulting in the formation of a less plasticized layer near the interface; unlike ethanol, PVC sheets stored in water showed a greater concentration of DEHP on the film surface as an exudation of DEHP onto the surface.
authors.affiliation: IFR 141, EA 401, UFR de Pharmacie - Université Paris Sud, 92290 Chatenay Malabry, France.
authors.forename: H
authors.initials: H
authors.lastname: Al Salloum
authors.affiliation: IFR 141, EA 401, UFR de Pharmacie - Université Paris Sud, 92290 Chatenay Malabry, France. Electronic address: johanna.saunier@u-psud.fr.
authors.forename: J
authors.initials: J
authors.lastname: Saunier
authors.affiliation: Lip(Sys)(2), UFR de Pharmacie - Université Paris Sud, 92290 Chatenay Malabry, France.
authors.forename: A
authors.initials: A
authors.lastname: Tfayli
authors.affiliation: IFR 141, EA 401, UFR de Pharmacie - Université Paris Sud, 92290 Chatenay Malabry, France.
authors.forename: N
authors.initials: N
authors.lastname: Yagoubi
mesh_terms: D004051:Diethylhexyl Phthalate / Q000737:chemistry*; D006801:Humans; D011143:Polyvinyl Chloride / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman
chemical_list: D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate
keywords: DEHP; Diffusion; Migration; PVC; Plasticizer; Raman spectroscopy