title: Advances in paediatric cancer treatment.
abstract: Four out of five children diagnosed with cancer can be cured with contemporary cancer therapy. This represents a dramatic improvement since 50 years ago when the cure rate of childhood cancer was <25% in the pre-chemotherapy era. Over the past ten years, while improvement in overall survival (OS) has been marginal, progress in pediatric oncology lies with adopting risk-adapted therapeutic approach. This has been made possible through identifying clinical and biologic prognostic factors with rigorous research and stratifying patients using these risk factors, and subsequently modifying therapy according to risk group assignment. This review provides a perspective for eight distinct pediatric malignancies, in which significant advances in treatment were made in the last decade and are leading to changes in standard of care. This includes four hematologic malignancies [acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL)] and four solid tumors [medulloblastoma (MB), low grade glioma (LGG), neuroblastoma (NB) and Ewing sarcoma (ES)]. Together, they comprise 60% of childhood cancer. Improved patient outcome is not limited to better survival, but encompasses reducing both short and long-term treatment-related complications which is as important as cure, given the majority of childhood cancer patients will become long-term survivors. Risk-adapted approach allows treatment intensification in the high-risk cohort while therapy can be de-escalated in the low-risk to minimize toxicity and late sequelae without compromising survival. Advances in medical research technology have also led to a rapid increase in the understanding of the genetics of childhood cancer in the last decade, facilitating identification of molecular targets that can potentially be exploited for therapeutic benefits. As we move into the era of targeted therapeutics, searching for novel agents that target specific genetic lesions becomes a major research focus. We provide an overview of seven novel agents (bevacizumab, bortezomib, vorinostat, sorafenib, tipifarnib, erlotinib and mTOR inhibitors), which have been most frequently pursued in childhood cancers in the last decade, as well as reporting the progress of clinical trials involving these agents.
authors.affiliation: 1 Children's Cancer Research Unit, Kid's Research Institute, The Children's Hospital at Westmead, Westmead, NSW, Australia ; 2 Oncology Department, The Children's Hospital at Westmead, Westmead, NSW, Australia ; 3 Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
authors.forename: Federica
authors.initials: F
authors.lastname: Saletta
authors.affiliation: 1 Children's Cancer Research Unit, Kid's Research Institute, The Children's Hospital at Westmead, Westmead, NSW, Australia ; 2 Oncology Department, The Children's Hospital at Westmead, Westmead, NSW, Australia ; 3 Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
authors.forename: Michaela S
authors.initials: MS
authors.lastname: Seng
authors.affiliation: 1 Children's Cancer Research Unit, Kid's Research Institute, The Children's Hospital at Westmead, Westmead, NSW, Australia ; 2 Oncology Department, The Children's Hospital at Westmead, Westmead, NSW, Australia ; 3 Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
authors.forename: Loretta M S
authors.initials: LM
authors.lastname: Lau
keywords: Cancer; advances; childhood; molecular; pediatric; treatment
references.citation: Nature. 2012 Feb 22;483(7391):589-93
references.pmid: 22367537
references.citation: J Clin Oncol. 2011 Aug 20;29(24):3293-300
references.pmid: 21768474
references.citation: J Clin Oncol. 2012 Apr 20;30(12):1358-63
references.pmid: 22393086
references.citation: J Clin Oncol. 2011 Dec 1;29(34):4534-40
references.pmid: 22025154
references.citation: Int J Hematol. 2013 Jun;97(6):683-94
references.pmid: 23613268
references.citation: Pediatr Hematol Oncol. 2012 Feb;29(1):1-11
references.pmid: 22295994
references.citation: Blood. 2013 Jul 4;122(1):37-43
references.pmid: 23704089
references.citation: Cancer. 2012 Feb 1;118(3):761-9
references.pmid: 21766293
references.citation: Leukemia. 2013 Apr;27(5):1174-7
references.pmid: 22940833
references.citation: J Neurosurg. 1997 May;86(5):747-54
references.pmid: 9126887
references.citation: J Clin Oncol. 2013 Dec 10;31(35):4424-30
references.pmid: 24127442
references.citation: Blood. 2006 Feb 1;107(3):1238-9
references.pmid: 16434496
references.citation: J Clin Oncol. 1990 Oct;8(10):1664-74
references.pmid: 2213103
references.citation: Blood. 2007 Apr 1;109(7):2773-80
references.pmid: 17132719
references.citation: Oncologist. 2003;8(6):508-13
references.pmid: 14657528
references.citation: J Clin Oncol. 2006 Jan 20;24(3):500-6
references.pmid: 16421427
references.citation: Blood. 2000 Jan 15;95(2):416-21
references.pmid: 10627444
references.citation: J Clin Oncol. 2009 Nov 1;27(31):5175-81
references.pmid: 19805687
references.citation: Neurologist. 2004 Nov;10(6):293-310
references.pmid: 15518596
references.citation: Ann Oncol. 2012 Apr;23 (4):990-6
references.pmid: 21810729
references.citation: J Clin Oncol. 2010 Nov 20;28(33):4969-75
references.pmid: 20921469
references.citation: J Clin Oncol. 2010 Jun 20;28(18):3069-75
references.pmid: 20479404
references.citation: Mol Ther Nucleic Acids. 2013 May 21;2:e93
references.pmid: 23695536
references.citation: Acta Neuropathol. 2011 Mar;121(3):381-96
references.pmid: 21267586
references.citation: Pediatr Blood Cancer. 2009 Mar;52(3):335-9
references.pmid: 18985718
references.citation: Pediatr Blood Cancer. 2006 Nov;47(6):795-800
references.pmid: 16411206
references.citation: Blood. 2011 Jul 14;118(2):243-51
references.pmid: 21562038
references.citation: J Clin Oncol. 2010 Aug 10;28(23):3680-6
references.pmid: 20625128
references.citation: Br J Haematol. 2008 Nov;143(4):541-7
references.pmid: 18759760
references.citation: Ann Intern Med. 1970 Dec;73(6):881-95
references.pmid: 5525541
references.citation: Lancet Oncol. 2013 Sep;14(10):999-1008
references.pmid: 23890779
references.citation: Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):782-7
references.pmid: 17892918
references.citation: Nat Biotechnol. 2007 Jan;25(1):84-90
references.pmid: 17211407
references.citation: Cancer. 1996 Aug 15;78(4):901-11
references.pmid: 8756388
references.citation: Genes Dev. 2004 Aug 15;18(16):1926-45
references.pmid: 15314020
references.citation: Pediatr Blood Cancer. 2013 Jun;60(6):1009-15
references.pmid: 23255238
references.citation: Br J Cancer. 2008 Oct 7;99(7):1027-33
references.pmid: 18766186
references.citation: Nat Rev Drug Discov. 2010 Jan;9(1):17-8
references.pmid: 20043026
references.citation: J Clin Oncol. 2005 Nov 1;23 (31):7951-7
references.pmid: 16258095
references.citation: Clin Cancer Res. 2009 Jan 15;15(2):701-7
references.pmid: 19147777
references.citation: Neuro Oncol. 2011 Mar;13(3):298-306
references.pmid: 21339191
references.citation: J Clin Oncol. 2007 Oct 20;25(30):4806-12
references.pmid: 17947729
references.citation: Lancet Oncol. 2010 Jun;11(6):543-52
references.pmid: 20451454
references.citation: Blood. 2008 Mar 1;111(5):2776-84
references.pmid: 17957027
references.citation: Blood. 2005 Feb 1;105(3):948-58
references.pmid: 15486066
references.citation: Oncologist. 2007 Aug;12 (8):991-8
references.pmid: 17766659
references.citation: Br J Haematol. 2010 Mar;148(5):768-76
references.pmid: 19995399
references.citation: J Clin Oncol. 2013 Apr 20;31(12):1562-8
references.pmid: 23509321
references.citation: Pediatr Blood Cancer. 2007 Dec;49(7):894-900
references.pmid: 17584910
references.citation: J Clin Oncol. 2005 Oct 20;23(30):7632-40
references.pmid: 16234524
references.citation: J Clin Oncol. 2012 Jul 20;30(21):2648-53
references.pmid: 22665539
references.citation: JAMA. 2012 Mar 14;307(10):1062-71
references.pmid: 22416102
references.citation: J Clin Oncol. 2002 Nov 15;20(22):4420-7
references.pmid: 12431963
references.citation: J Clin Oncol. 2008 Jan 20;26(3):399-405
references.pmid: 18202416
references.citation: Clin Cancer Res. 2013 Jan 1;19(1):236-46
references.pmid: 23143218
references.citation: Blood. 2005 Jul 15;106(2):447-53
references.pmid: 15677559
references.citation: J Clin Oncol. 2004 Oct 1;22(19):3916-21
references.pmid: 15459213
references.citation: Br J Haematol. 2008 Jun;141(6):840-7
references.pmid: 18371107
references.citation: Neuro Oncol. 2011 Aug;13(8):910-5
references.pmid: 21764821
references.citation: J Clin Oncol. 2012 Nov 10;30(32):3924-31
references.pmid: 22851554
references.citation: PLoS One. 2011 Apr 20;6(4):e18856
references.pmid: 21533094
references.citation: Blood. 2001 Jun 1;97(11):3370-9
references.pmid: 11369626
references.citation: Leukemia. 2005 Dec;19(12):2130-8
references.pmid: 16304572
references.citation: J Clin Oncol. 2000 Jan;18(1):4-11
references.pmid: 10623687
references.citation: Cancer. 2012 Oct 1;118(19):4806-14
references.pmid: 22392565
references.citation: Ann Hematol. 2006 May;85(5):275-80
references.pmid: 16518605
references.citation: Acta Neuropathol. 2012 Apr;123(4):465-72
references.pmid: 22134537
references.citation: J Clin Oncol. 2012 Jan 20;30(3):256-62
references.pmid: 22184397
references.citation: Clin Cancer Res. 2013 Jul 1;19(13):3649-58
references.pmid: 23659969
references.citation: N Engl J Med. 2003 Feb 20;348(8):694-701
references.pmid: 12594313
references.citation: Ann Oncol. 1998 Mar;9(3):275-81
references.pmid: 9602261
references.citation: J Clin Oncol. 2005 May 20;23(15):3376-82
references.pmid: 15908649
references.citation: Nat Rev Drug Discov. 2007 Feb;6(2):149-65
references.pmid: 17268486
references.citation: J Clin Oncol. 2011 Jan 20;29(3):310-5
references.pmid: 21149663
references.citation: J Clin Oncol. 2010 Jul 10;28(20):3284-91
references.pmid: 20547982
references.citation: J Clin Oncol. 2011 Feb 1;29(4):369-77
references.pmid: 21172891
references.citation: Neurosurgery. 2011 Jun;68(6):1548-54; discussion 1554-5
references.pmid: 21368693
references.citation: Clin Cancer Res. 2012 Nov 1;18(21):6011-22
references.pmid: 22962440
references.citation: JAMA. 2012 Jun 27;307(24):2609-16
references.pmid: 22735430
references.citation: Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5291-4
references.pmid: 17875757
references.citation: J Clin Oncol. 2009 Jan 10;27(2):289-97
references.pmid: 19047291
references.citation: J Clin Oncol. 2008 Oct 20;26(30):4921-7
references.pmid: 18794549
references.citation: Clin Cancer Res. 2012 May 1;18(9):2679-86
references.pmid: 22421195
references.citation: Lancet Oncol. 2009 Oct;10(10):957-66
references.pmid: 19747876
references.citation: Blood. 2012 Aug 23;120(8):1570-80; quiz 1752
references.pmid: 22715121
references.citation: Pediatr Blood Cancer. 2009 Dec 15;53(7):1231-7
references.pmid: 19621457
references.citation: Blood. 2012 Aug 23;120(8):1581-8
references.pmid: 22649108
references.citation: Cancer. 2007 Dec 1;110(11):2535-41
references.pmid: 17932894
references.citation: Curr Treat Options Neurol. 2006 Jul;8(4):319-34
references.pmid: 16942675
references.citation: Clin Cancer Res. 2006 Dec 15;12(24):7271-8
references.pmid: 17189398
references.citation: Oncologist. 2012;17(8):1081-9
references.pmid: 22733795
references.citation: J Clin Oncol. 1993 Jun;11(6):1024-32
references.pmid: 8501488
references.citation: Pediatr Blood Cancer. 2009 Sep;53(3):392-6
references.pmid: 19459198
references.citation: Pediatr Blood Cancer. 2011 Feb;56(2):226-33
references.pmid: 20860038
references.citation: Blood. 2007 Apr 1;109(7):2736-43
references.pmid: 17138821
references.citation: Clin Cancer Res. 2007 Mar 1;13(5):1516-22
references.pmid: 17332297
references.citation: Pediatr Blood Cancer. 2013 Jan;60(1):71-6
references.pmid: 22434731
references.citation: J Clin Oncol. 2009 Feb 1;27(4):566-71
references.pmid: 19075266
references.citation: Int J Radiat Oncol Biol Phys. 1998 Jul 15;41(5):979-87
references.pmid: 9719106
references.citation: Clin Cancer Res. 2006 Mar 15;12(6):1750-9
references.pmid: 16551859
references.citation: Br J Haematol. 2011 Feb;152(4):441-51
references.pmid: 21210776
references.citation: N Engl J Med. 2013 Apr 18;368(16):1509-18
references.pmid: 23527958
references.citation: J Clin Oncol. 2011 Feb 10;29(5):551-65
references.pmid: 21220611
references.citation: J Clin Oncol. 2012 Jul 20;30(21):2641-7
references.pmid: 22665535
references.citation: Blood. 2006 Dec 1;108(12):3654-61
references.pmid: 16912228
references.citation: Ann Surg. 2012 Oct;256(4):573-80
references.pmid: 22964741
references.citation: J Clin Oncol. 2006 Sep 1;24(25):4202-8
references.pmid: 16943538
references.citation: J Neurosurg. 1995 Apr;82(4):536-47
references.pmid: 7897512
references.citation: Am J Transplant. 2012 Nov;12(11):3069-75
references.pmid: 22883417
references.citation: Lancet Oncol. 2010 Feb;11(2):129-35
references.pmid: 20036194
references.citation: Pediatr Blood Cancer. 2009 Dec;53(6):1029-34
references.pmid: 19637327
references.citation: Oncology (Williston Park). 2007 Dec;21(14):1696-706; discussion 1706-9, 1712, 1715
references.pmid: 18247017
references.citation: Clin Cancer Res. 2005 Sep 15;11(18):6414-21
references.pmid: 16166415
references.citation: J Clin Oncol. 2010 Nov 20;28(33):4961-8
references.pmid: 20940197
references.citation: N Engl J Med. 2011 Aug 25;365(8):725-33
references.pmid: 21830940
references.citation: Klin Padiatr. 2012 Oct;224(6):398-403
references.pmid: 22915450
references.citation: J Clin Oncol. 1993 May;11(5):850-6
references.pmid: 8487049
references.citation: J Clin Oncol. 2007 Dec 1;25(34):5442-7
references.pmid: 18048827
references.citation: Drugs Today (Barc). 2005 Jan;41(1):23-36
references.pmid: 15753967
references.citation: J Clin Oncol. 2004 Dec 1;22(23):4804-9
references.pmid: 15570082
references.citation: Pediatr Blood Cancer. 2013 Mar;60(3):390-5
references.pmid: 22887890
references.citation: Blood. 2008 Jun 15;111(12):5663-71
references.pmid: 17984313
references.citation: Pediatr Blood Cancer. 2013 Mar;60(3):396-401
references.pmid: 22961690
references.citation: PLoS One. 2013 Oct 11;8(10):e76455
references.pmid: 24146872
references.citation: Expert Opin Investig Drugs. 2010 Dec;19(12 ):1569-80
references.pmid: 21083522
references.citation: J Clin Oncol. 2002 Apr 15;20(8):2142-9
references.pmid: 11956276
references.citation: Br Med J (Clin Res Ed). 1988 May 14;296(6633):1372-6
references.pmid: 2840171
references.citation: Nat Rev Cancer. 2004 May;4(5):349-60
references.pmid: 15122206
references.citation: Br J Haematol. 2013 Sep;162(5):606-20
references.pmid: 23808872
references.citation: Nat Rev Cancer. 2012 Dec;12(12):818-34
references.pmid: 23175120
references.citation: J Clin Oncol. 2003 Jul 1;21(13):2486-91
references.pmid: 12829667
references.citation: Eur J Cancer. 2010 Aug;46(12):2253-9
references.pmid: 20400294
references.citation: Clin Cancer Res. 2012 May 1;18(9):2625-31
references.pmid: 22465830
references.citation: Neuro Oncol. 2012 Oct;14(10):1265-84
references.pmid: 22942186
references.citation: Nat Genet. 2013 Mar;45(3):279-84
references.pmid: 23334666
references.citation: Eur J Cancer. 2012 Jan;48(2):253-62
references.pmid: 22033322
references.citation: Hematology Am Soc Hematol Educ Program. 2012;2012:389-96
references.pmid: 23233609
references.citation: Science. 2008 Aug 15;321(5891):974-7
references.pmid: 18703743
references.citation: Pediatr Blood Cancer. 2013 Sep;60(9):1452-7
references.pmid: 23554030
references.citation: J Clin Oncol. 2000 Sep;18(17):3108-14
references.pmid: 10963639
references.citation: Blood. 2005 Jul 1;106(1):376-83
references.pmid: 15755898
references.citation: Blood. 2010 Nov 11;116(19):3751-7
references.pmid: 20705755
references.citation: Blood. 2009 Sep 17;114(12):2489-96
references.pmid: 19528532
references.citation: J Clin Oncol. 2010 Dec 20;28(36):5321-6
references.pmid: 21041712
references.citation: Pediatr Blood Cancer. 2007 Nov;49(6):808-11
references.pmid: 17588234
references.citation: J Clin Oncol. 2005 Oct 20;23(30):7621-31
references.pmid: 16234523
references.citation: Eur J Cancer. 2012 Jun;48(9):1376-85
references.pmid: 22516209
references.citation: J Neurooncol. 1997 May;32(3):235-41
references.pmid: 9049885
references.citation: Neuro Oncol. 2014 Jan;16(2):310-7
references.pmid: 24311632
references.citation: Neuro Oncol. 2012 Nov;14 (11):1404-12
references.pmid: 23019233
references.citation: Blood. 2008 Feb 1;111(3):1560-6
references.pmid: 17957029
references.citation: Cancer. 1990 Jan 1;65(1):45-52
references.pmid: 2104571
references.citation: J Clin Oncol. 2011 Feb 1;29(4):449-55
references.pmid: 21172879
references.citation: J Clin Oncol. 2008 Mar 20;26(9):1504-10
references.pmid: 18349403
references.citation: Nat Rev Cancer. 2003 Mar;3(3):203-16
references.pmid: 12612655
references.citation: N Engl J Med. 2009 Jun 25;360(26):2730-41
references.pmid: 19553647
references.citation: Blood. 2011 Jul 28;118(4):874-83
references.pmid: 21474675
references.citation: Lancet Oncol. 2013 May;14(6):472-80
references.pmid: 23598171
references.citation: Expert Opin Investig Drugs. 2007 Mar;16(3):381-92
references.pmid: 17302532
references.citation: J Clin Oncol. 2012 Nov 20;30(33):4148-54
references.pmid: 23091096
references.citation: Nat Clin Pract Oncol. 2004 Nov;1(1):39-43
references.pmid: 16264798
references.citation: Expert Opin Pharmacother. 2010 Aug;11(11):1943-55
references.pmid: 20586710
references.citation: Curr Opin Oncol. 2013 Dec;25 Suppl 3:S1-13; quiz S14-6
references.pmid: 24305505
references.citation: Pediatr Blood Cancer. 2014 Mar;61(3):457-63
references.pmid: 24039013
references.citation: Ann Oncol. 2003;14 Suppl 5:v119-27
references.pmid: 14684502
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9414-8
references.pmid: 19470474
references.citation: Lancet Oncol. 2006 Oct;7(10):813-20
references.pmid: 17012043
references.citation: Leukemia. 2006 Aug;20(8):1368-76
references.pmid: 16761017
references.citation: N Engl J Med. 2010 Sep 30;363(14):1324-34
references.pmid: 20879881
references.citation: Pediatr Blood Cancer. 2008 Jun;50(6):1169-75
references.pmid: 18293379
references.citation: Pediatr Blood Cancer. 2012 Dec 15;59(7):1259-65
references.pmid: 22911615
references.citation: J Clin Oncol. 2011 Jul 20;29(21):2933-40
references.pmid: 21690471
references.citation: Cancer Res. 1997 Nov 1;57(21):4838-48
references.pmid: 9354447
references.citation: Blood. 2011 Mar 3;117(9):2596-603
references.pmid: 21079154
references.citation: J Neurosurg. 1991 May;74(5):701-8
references.pmid: 1901597
references.citation: Cancer. 2009 Aug 1;115(15):3475-82
references.pmid: 19536896
references.citation: J Child Neurol. 2009 Nov;24(11):1397-408
references.pmid: 19841428
references.citation: J Clin Oncol. 2006 Jun 1;24(16):2570-5
references.pmid: 16735710
references.citation: N Engl J Med. 1994 Dec 1;331(22):1500-7
references.pmid: 7969301
references.citation: Neuro Oncol. 2008 Jun;10 (3):341-7
references.pmid: 18417739
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Jun 29;362(1482):959-71
references.pmid: 17317642
references.citation: Lancet. 2012 Apr 21;379(9825):1508-16
references.pmid: 22482940
references.citation: Blood. 2013 Jan 10;121(2):278-85
references.pmid: 23149845
references.citation: J Clin Oncol. 2009 Aug 20;27(24):4007-13
references.pmid: 19620491
references.citation: Leukemia. 2009 Aug;23(8):1490-9
references.pmid: 19262598
references.citation: J Clin Oncol. 2012 May 20;30(15):1849-56
references.pmid: 22508822
references.citation: Pediatr Blood Cancer. 2005 Jan;44(1):33-9
references.pmid: 15390307
references.citation: Pediatr Blood Cancer. 2013 Sep;60(9):1447-51
references.pmid: 23630159
references.citation: Blood. 2012 Jul 12;120(2):285-90
references.pmid: 22653976
references.citation: J Clin Oncol. 2001 Aug 1;19(15):3463-9
references.pmid: 11481351
references.citation: Leukemia. 2009 Jun;23(6):1127-30
references.pmid: 19194463
references.citation: Eur J Cancer. 2008 Jul;44(11):1552-8
references.pmid: 18424129
references.citation: J Clin Oncol. 2010 Aug 1;28(22):3623-9
references.pmid: 20606092
references.citation: J Clin Oncol. 2012 May 20;30(15):1842-8
references.pmid: 22529259
references.citation: J Clin Oncol. 2012 Jun 20;30(18):2190-6
references.pmid: 22614995
references.citation: Blood. 2011 Feb 10;117(6):1806-16
references.pmid: 21037086
references.citation: Blood. 2009 Sep 3;114(10):2051-9
references.pmid: 19584400
references.citation: Blood. 2012 Dec 13;120(25):4913-20
references.pmid: 22932799
references.citation: Oncologist. 2009 Jan;14(1):95-100
references.pmid: 19144678
references.citation: Biologics. 2013;7:139-48
references.pmid: 23788831
references.citation: Jpn J Clin Oncol. 2013 Nov;43(11):1073-9
references.pmid: 24002900
references.citation: Leukemia. 2010 Sep;24(9):1599-606
references.pmid: 20668473
references.citation: N Engl J Med. 1983 Mar 10;308(10):559-65
references.pmid: 6338381
references.citation: Pediatr Blood Cancer. 2009 Jul;52(7):791-5
references.pmid: 19165892
references.citation: Nat Rev Neurol. 2012 May 08;8(6):340-51
references.pmid: 22565209
references.citation: N Engl J Med. 2010 Sep 30;363(14):1313-23
references.pmid: 20879880
references.citation: Pediatr Blood Cancer. 2010 Aug;55(2):254-9
references.pmid: 20582937
references.citation: Curr Opin Investig Drugs. 2010 Jun;11(6):707-18
references.pmid: 20496266
references.citation: PLoS One. 2013 Jul 22;8(7):e68416
references.pmid: 23894304
references.citation: J Nucl Med. 2013 Apr;54(4):541-8
references.pmid: 23440556
references.citation: J Clin Oncol. 2006 Jan 20;24(3):507-16
references.pmid: 16421428
references.citation: Leukemia. 2011 Aug;25(8):1239-48
references.pmid: 21566656
references.citation: Neuro Oncol. 2011 Jan;13(1):109-18
references.pmid: 20974795
references.citation: Surg Oncol Clin N Am. 2013 Oct;22(4):641-64
references.pmid: 24012393
references.citation: Cancer Treat Rev. 2014 Mar;40(2):285-92
references.pmid: 24112812
references.citation: Lancet Oncol. 2006 May;7(5):379-91
references.pmid: 16648042
references.citation: Lancet. 2002 Jun 1;359(9321):1909-15
references.pmid: 12057554
references.citation: Ann Neurol. 2007 Mar;61(3):189-98
references.pmid: 17387725
references.citation: Blood. 2012 Oct 18;120(16):3187-205
references.pmid: 22879540
references.citation: J Clin Oncol. 2010 Jul 1;28(19):3115-21
references.pmid: 20516455
references.citation: Blood. 2007 Feb 1;109(3):896-904
references.pmid: 17003366
references.citation: J Cell Biochem. 2009 Jul 1;107(4):600-8
references.pmid: 19459166
references.citation: Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6
references.pmid: 12391318
references.citation: J Clin Oncol. 2012 Sep 10;30(26):3187-93
references.pmid: 22851561