title: Biological evaluation of nanosilver incorporated cellulose pulp for hygiene products.
abstract: Cellulose pulp has a visible market share in personal hygiene products such as sanitary napkins and baby diapers. However it offers good surface for growth of microorganisms. Huge amount of research is going on in developing hygiene products that do not initiate microbial growth. The objective of the present work is to produce antibacterial cellulose pulp by depositing silver nanopowder on the cellulose fiber. The silver nanoparticles used were of less than 100 nm in size and were characterised using transmission electron microscopy and X-ray powder diffraction studies. Antibacterial activity of the functionalized cellulose pulp was proved by JIS L 1902 method. The in-vitro cytotoxicity, in-vivo vaginal irritation and intracutaneous reactivity studies were done with silver nanopowder incorporated cellulose pulp for introducing a new value added product to the market. Cytotoxicity evaluation suggested that the silver nanoparticle incorporated cellulose pulp is non-cytotoxic. No irritation and skin sensitization were identified in animals tested with specific extracts prepared from the test material in the in-vivo experiments. The results indicated that the silver nanopowder incorporated cellulose pulp meets the requirements of the standard practices recommended for evaluating the biological reactivity and has good biocompatibility, hence can be classified as a safe hygiene product.
authors.affiliation: Corporate R & D Centre, HLL Lifecare Ltd., Akkulam, Sreekariyam P.O., Thiruvananthapuram 695 017, Kerala, India.
authors.forename: P C
authors.initials: PC
authors.lastname: Kavitha Sankar
authors.affiliation: Corporate R & D Centre, HLL Lifecare Ltd., Akkulam, Sreekariyam P.O., Thiruvananthapuram 695 017, Kerala, India.
authors.forename: Reshmi
authors.initials: R
authors.lastname: Ramakrishnan
authors.affiliation: Corporate R & D Centre, HLL Lifecare Ltd., Akkulam, Sreekariyam P.O., Thiruvananthapuram 695 017, Kerala, India. Electronic address: rosemarymj@lifecarehll.com.
authors.forename: M J
authors.initials: MJ
authors.lastname: Rosemary
mesh_terms: D000818:Animals; D002460:Cell Line; D002482:Cellulose / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006920:Hygiene; D008297:Male; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D011817:Rabbits; D012834:Silver / Q000737:chemistry / Q000494:pharmacology
chemical_list: D012834:Silver; D002482:Cellulose
keywords: Antibacterial; Cellulose pulp; Cytotoxicity; JIS method; Silver nanoparticles; Vaginal irritation