title: KiSS-1 expression in oral squamous cell carcinoma and its prognostic significance.
abstract: Downregulated expression of KiSS-1 has been correlated with tumor progression, metastasis, and patient prognosis in various human malignancies. However, there is no information regarding the expression of KiSS-1 in oral squamous cell carcinoma (OSCC). Our aims were to examine KiSS-1 expression in OSCC tissue samples and cell lines and to determine its prognostic significance. KiSS-1 expression was significantly lower in lymph node (LN) metastases than in primary tumor tissues. Five of six OSCC cell lines showed absence or relatively low expression of KiSS-1. Correlations between KiSS-1 expression and clinicopathological parameters were statistically assessed. There were significant correlations between KiSS-1 expression and LN metastasis (p = 0.007), TNM stage (p = 0.024), and local recurrence (p = 0.012). In the Kaplan-Meier survival analysis, negative KiSS-1 expression significantly correlated with poorer overall survival (OS) and disease-free survival (DFS) (p = 0.000 and 0.000, respectively). Multivariate analysis using Cox regression modeling revealed that KiSS-1 expression was an independent prognostic factor for both OS and DFS (p = 0.001 and 0.000, respectively). Our findings suggested that KiSS-1 downregulation may play a role in tumor progression and metastasis of OSCC and may be a reliable biomarker for predicting clinical outcome in OSCC.
authors.affiliation: Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Wui-Jung
authors.initials: WJ
authors.lastname: Shin
authors.affiliation: Department of Oral and Maxillofacial Pathology, School of Dentistry, Kyung Hee University, Seoul, Korea.
authors.forename: Young-Ah
authors.initials: YA
authors.lastname: Cho
authors.affiliation: Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Kyung-Rim
authors.initials: KR
authors.lastname: Kang
authors.affiliation: Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.|Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.|Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Seong-Doo
authors.initials: SD
authors.lastname: Hong
authors.affiliation: Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.|Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Jae-Il
authors.initials: JI
authors.lastname: Lee
authors.affiliation: Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.|Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Sam-Pyo
authors.initials: SP
authors.lastname: Hong
authors.affiliation: Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.|Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Hye-Jung
authors.initials: HJ
authors.lastname: Yoon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D015870:Gene Expression; D006801:Humans; D059648:Kisspeptins / Q000235:genetics*; D008198:Lymph Nodes / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis
chemical_list: C106628:KISS1 protein, human; D059648:Kisspeptins
keywords: KiSS-1; metastasis; oral squamous cell carcinoma; prognosis