title: Separation of [(99m)Tc]pertechnetate and molybdate using polyethylene glycol coated C18 and C30 resins.
abstract: Hydrophobic adsorbents such as C18 and C30 were coated with PEG and subsequently used for the separation of Mo/Tc. The most effective resin for adsorbing PEG was the C18-U resin, which demonstrated a coating capacity of 97.6±2.8mg PEG per g of resin. The ability to adsorb pertechnetate was proportional to the amount of PEG coated on the hydrophobic resin. The [(99m)Tc]pertechnetate recovery during the separation of cyclotron produced (99m)Tc from (100)Mo was 91.8±0.3% (n=2). The resultant product met relevant USP monograph specifications.
authors.affiliation: University of Alberta, Medical Isotope and Cyclotron Facility, Edmonton, AB, Canada. Electronic address: janderss@ualberta.ca.
authors.forename: J D
authors.initials: JD
authors.lastname: Andersson
authors.affiliation: Edmonton PET Centre, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
authors.forename: J S
authors.initials: JS
authors.lastname: Wilson
authors.affiliation: University of Alberta, Medical Isotope and Cyclotron Facility, Edmonton, AB, Canada.
authors.forename: J A
authors.initials: JA
authors.lastname: Romaniuk
authors.affiliation: Edmonton PET Centre, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
authors.forename: A J B
authors.initials: AJB
authors.lastname: McEwan
authors.affiliation: University of Alberta, Medical Isotope and Cyclotron Facility, Edmonton, AB, Canada.
authors.forename: D N
authors.initials: DN
authors.lastname: Abrams
authors.affiliation: University of Alberta, Medical Isotope and Cyclotron Facility, Edmonton, AB, Canada.
authors.forename: S A
authors.initials: SA
authors.lastname: McQuarrie
authors.affiliation: University of Alberta, Medical Isotope and Cyclotron Facility, Edmonton, AB, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Gagnon
mesh_terms: D000327:Adsorption; D017357:Cyclotrons; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007554:Isotopes / Q000302:isolation & purification; D008982:Molybdenum / Q000302:isolation & purification*; D011092:Polyethylene Glycols; D011868:Radioisotopes / Q000302:isolation & purification; D019275:Radiopharmaceuticals / Q000302:isolation & purification; D012117:Resins, Synthetic; D013670:Sodium Pertechnetate Tc 99m / Q000302:isolation & purification*
chemical_list: D007554:Isotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012117:Resins, Synthetic; C044659:molybdate; D011092:Polyethylene Glycols; D008982:Molybdenum; D013670:Sodium Pertechnetate Tc 99m
keywords: 100Mo; 99mTc; Aqueous biphasic extraction chromatography; C18; C30; Cyclotron; Molybdate; Pertechnetate; Polyethylene glycol