title: Octreotide and enterocutaneous fistula closure in neonates and children.
abstract: Enterocutaneous fistula and its conservative management still pose a challenge for the surgeon. The use of octreotide and somatostatin in neonates and children as adjunctive therapy in the conservative management of this condition, leads to major controversy regarding its efficacy. Therefore, we conducted an extensive literature review of published articles regarding the use of somatostatin and its analogues in the treatment of enterocutaneous fistula in neonates and children. Our review is then presented together with a case vignette and discusses the different practical aspects of the treatment with these drugs.
  
  
  CONCLUSIONS
  The major diversity in treatment regimens among published studies makes outcomes difficult to compare. However, given the results of the different cases reported in the literature and of our own experience, we suggest a possible beneficial effect of octreotide and somatostatin on closure of enterocutaneous fistula in these patients.
authors.affiliation: Department of Pediatric Surgery, Complejo Hospitalario de Toledo, Avenida de Barber, No 30, 45004, Toledo, Spain. noelacarrera@hotmail.com.
authors.forename: Noela
authors.initials: N
authors.lastname: Carrera-Guermeur
authors.affiliation: Department of Pediatric Surgery, Complejo Hospitalario de Toledo, Avenida de Barber, No 30, 45004, Toledo, Spain. rmartincrespo@movistar.es.
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Martín-Crespo
authors.affiliation: Department of Pediatric Surgery, Complejo Hospitalario de Toledo, Avenida de Barber, No 30, 45004, Toledo, Spain. hilda_317@hotmail.com.
authors.forename: Hilda J
authors.initials: HJ
authors.lastname: Ramírez
authors.affiliation: Division of Neonatology, Department of Pediatrics, Complejo Hospitalario de Toledo, Avenida de Barber, No 30, 45004, Toledo, Spain. angelp@sescam.jccm.es.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Pantoja
authors.affiliation: Department of Pediatric Surgery, Complejo Hospitalario de Toledo, Avenida de Barber, No 30, 45004, Toledo, Spain. rluquemialdea@telefonica.net.
authors.forename: Rafael
authors.initials: R
authors.lastname: Luque-Mialdea
mesh_terms: D002648:Child; D002675:Child, Preschool; D000072700:Conservative Treatment; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007412:Intestinal Fistula / Q000188:drug therapy*; D008297:Male; D015282:Octreotide / Q000009:adverse effects / Q000627:therapeutic use*; D013004:Somatostatin / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D005765:Gastrointestinal Agents; D013004:Somatostatin; D015282:Octreotide
keywords: Enterocutaneous fistula; Neonate; Octreotide; Somatostatin
references.citation: Am J Hosp Pharm. 1994 May 1;51(9):1184-92
references.pmid: 8042637
references.citation: Can J Gastroenterol. 2004 May;18(5):303-6
references.pmid: 15152279
references.citation: Clin Pediatr (Phila). 1989 Mar;28(3):149-50
references.pmid: 2563961
references.citation: J Pediatr Gastroenterol Nutr. 2002 Nov;35(5):600-9
references.pmid: 12454572
references.citation: N Engl J Med. 1996 Jan 25;334(4):246-54
references.pmid: 8532003
references.citation: Eur J Pediatr Surg. 2008 Feb;18(1):56-8
references.pmid: 18302073
references.citation: Ann Surg. 2012 Dec;256(6):946-54
references.pmid: 22885696
references.citation: Eur J Pediatr. 2000 Jul;159(7):550
references.pmid: 10923237
references.citation: Am J Ther. 2001 Nov-Dec;8(6):409-15
references.pmid: 11704779
references.citation: World J Surg. 1995 May-Jun;19(3):430-3; discussion 433-4
references.pmid: 7639001
references.citation: J Pediatr Surg. 2003 Feb;38(2):251-3
references.pmid: 12596116
references.citation: Hepatogastroenterology. 2002 Jul-Aug;49(46):1010-2
references.pmid: 12143189
references.citation: Turk J Pediatr. 2004 Jul-Sep;46(3):289-91
references.pmid: 15503489
references.citation: Pediatr Diabetes. 2010 Mar;11(2):142-7
references.pmid: 19558634
references.citation: Eur J Gastroenterol Hepatol. 2011 Oct;23(10):912-22
references.pmid: 21814141
references.citation: Adv Med Sci. 2008;53(2):331-4
references.pmid: 18762471
references.citation: Pharmacotherapy. 2011 Sep;31(9):924
references.pmid: 21923595
references.citation: World J Surg. 2008 Mar;32(3):436-43; discussion 444
references.pmid: 18057983
references.citation: J Pediatr Surg. 1978 Feb;13(1):1-4
references.pmid: 416196
references.citation: Gut. 2001 Dec;49 Suppl 4:iv11-21
references.pmid: 11878789
references.citation: Pediatr Crit Care Med. 2004 Jul;5(4):356-7
references.pmid: 15215005
references.citation: HPB Surg. 1996;9(3):183-4
references.pmid: 8725462
references.citation: Saudi J Gastroenterol. 2012 Mar-Apr;18(2):87-94
references.pmid: 22421712
references.citation: Dig Dis Sci. 1987 Oct;32(10):1092-6
references.pmid: 2888608
references.citation: World J Surg. 2000 May;24(5):533-7; discussion 538
references.pmid: 10787072
references.citation: Surgery. 2006 Oct;140(4):570-6; discussion 576-8
references.pmid: 17011904
references.citation: Br J Surg. 2004 Dec;91(12):1646-51
references.pmid: 15505866
references.citation: Afr J Paediatr Surg. 2012 Jan-Apr;9(1):40-6
references.pmid: 22382103
references.citation: Am Surg. 1995 Mar;61(3):206-9
references.pmid: 7887530
references.citation: Eur J Pediatr. 1994 May;153(5):304-10
references.pmid: 8033916
references.citation: J Pediatr Gastroenterol Nutr. 1990 Apr;10(3):402-4
references.pmid: 2324901
references.citation: Am J Hosp Pharm. 1994 May 15;51(10):1317-30
references.pmid: 8085570
references.citation: J Pediatr Surg. 2008 Jun;43(6):1209-10
references.pmid: 18558210
references.citation: Science. 1973 Jan 5;179(4068):77-9
references.pmid: 4682131
references.citation: Am J Gastroenterol. 1995 Jul;90(7):1042-52
references.pmid: 7611194
references.citation: J Pediatr Surg. 1991 Sep;26(9):1097-100
references.pmid: 1941488
references.citation: Digestion. 1999;60 Suppl 2:53-6
references.pmid: 10207232
references.citation: J Pediatr Gastroenterol Nutr. 1987 May-Jun;6(3):466-70
references.pmid: 2892904
references.citation: Arch Dis Child. 1993 Jan;68(1):135-6
references.pmid: 8434999
references.citation: Gut. 1994;35(3 Suppl):S1-4
references.pmid: 7911441