title: Yessotoxin, a Promising Therapeutic Tool.
abstract: Yessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in filter feeding shellfish. No records about human intoxications induced by this compound have been published, however it is considered a toxin. Modifications in second messenger levels, protein levels, immune cells, cytoskeleton or activation of different cellular death types have been published as consequence of YTX exposure. This review summarizes the main intracellular pathways modulated by YTX and their pharmacological and therapeutic implications.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain. amparo.alfonso@usc.es.
authors.forename: Amparo
authors.initials: A
authors.lastname: Alfonso
authors.affiliation: Department of Physiology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain. mmercedes.rodriguez@usc.es.
authors.forename: Mercedes R
authors.initials: MR
authors.lastname: Vieytes
authors.affiliation: Department of Physiology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain. luis.botana@usc.es.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Botana
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D004141:Dinoflagellida / Q000378:metabolism*; D006801:Humans; D008978:Mollusk Venoms; D035964:Oxocins / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D015290:Second Messenger Systems / Q000187:drug effects; D012758:Shellfish / Q000032:analysis*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D008978:Mollusk Venoms; D035964:Oxocins; C066632:yessotoxin
keywords: Alzheimer; apoptosis; autophagy; cellular death; cytoskeleton; glucose metabolism; immune system; signal transduction; yessotoxin (YTX)
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