title: Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination.
abstract: We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol-gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-α-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus.
authors.affiliation: Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. br.degeest@ugent.be.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde, Belgium and Inflammation Research Center, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Schepens
authors.affiliation: Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. br.degeest@ugent.be.
authors.forename: L
authors.initials: L
authors.lastname: Nuhn
authors.affiliation: Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde, Belgium and Inflammation Research Center, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium.
authors.forename: X
authors.initials: X
authors.lastname: Saelens
authors.affiliation: Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde, Belgium and Inflammation Research Center, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Schotsaert
authors.affiliation: Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde, Belgium and Inflammation Research Center, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium.
authors.forename: N
authors.initials: N
authors.lastname: Callewaert
authors.affiliation: Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde, Belgium and Inflammation Research Center, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: De Rycke
authors.affiliation: Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry, Krijgslaan 281, 9000 Ghent, Belgium.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Laboratory of Polymeric & Composite Materials, Ctr Innovat & Res Mat & Polymers (CIRMAP), Material Res Inst. and Health Res. Inst., University of Mons, B-7000 Mons, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Moins
authors.affiliation: Laboratory of Polymeric & Composite Materials, Ctr Innovat & Res Mat & Polymers (CIRMAP), Material Res Inst. and Health Res. Inst., University of Mons, B-7000 Mons, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Benali
authors.affiliation: Laboratory of Polymeric & Composite Materials, Ctr Innovat & Res Mat & Polymers (CIRMAP), Material Res Inst. and Health Res. Inst., University of Mons, B-7000 Mons, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Mespouille
authors.affiliation: Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry, Krijgslaan 281, 9000 Ghent, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Hoogenboom
authors.affiliation: Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. br.degeest@ugent.be.
authors.forename: B G
authors.initials: BG
authors.lastname: De Geest
mesh_terms: D000586:Amination; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers; D006046:Gold