title: Overview: Detection of Human Papillomavirus in Clinical Samples.
abstract: Human papillomavirus (HPV) is the most common sexually-transmitted virus and it is known that persistent infection by high-risk HPV is a necessary factor for cervical carcinogenesis. Although cytological screening has decreased the incidence of cervical cancer, the sensitivity and specificity of testing is limited. To date, HPV-driven molecular techniques have provided a number of potential biomarkers for both diagnostic and prognostic use in clinical management. In addition, they can provide insights into the biology of HPV-induced cancers leading to non-surgical therapy. This review summarizes current knowledge of detection methods for HPV and related biomarkers that can be used to discriminate lesions with a high risk of progression of cervical cancer.
authors.forename: Preeda
authors.initials: P
authors.lastname: Prakrankamanant
authors.forename: Metee
authors.initials: M
authors.lastname: Wongsena
mesh_terms: D015415:Biomarkers / Q000032:analysis; D019411:Clinical Laboratory Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis; D014773:Virology / Q000379:methods*
chemical_list: D015415:Biomarkers