title: Prevalence of salivary Epstein-Barr virus in potentially malignant oral disorders and oral squamous cell carcinoma.
abstract: BACKGROUND
  To analyze the presence of salivary Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma and potentially malignant oral disorders.
  
  
  METHODS
  Three groups were studied: Group 1 (12 oral squamous cell carcinomas (OSCC)), Group 2 (12 potentially malignant oral disorders (PMD)) and Group 3 (47 healthy controls). EBV DNA salivary analysis was performed by PCR.
  
  
  RESULTS
  The highest percentage of positive salivary EBV DNA corresponded to the OSCC group (58.3%), followed by the PMD group (41.7%) and the controls (40.4%). The differences between groups were not statistically significant, however (p>0.05).
  
  
  CONCLUSIONS
  Salivary EBV DNA was more prevalent in OSCC than in PMD or the controls.
authors.affiliation: Oral Medicine Department, C/ Gasco Oliag 1, 46010 Valencia, Spain, bagan@uv.es.
authors.forename: Leticia
authors.initials: L
authors.lastname: Bagan
authors.forename: María-Dolores
authors.initials: MD
authors.lastname: Ocete-Monchon
authors.forename: Manuel
authors.initials: M
authors.lastname: Leopoldo-Rodado
authors.forename: Judith
authors.initials: J
authors.lastname: Murillo-Cortes
authors.forename: Jose-M
authors.initials: JM
authors.lastname: Díaz-Fernández
authors.forename: Rafael
authors.initials: R
authors.lastname: Medina-Gonzalez
authors.forename: Concepción
authors.initials: C
authors.lastname: Gimeno-Cardona
authors.forename: Jose-V
authors.initials: JV
authors.lastname: Bagan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000821:virology*; D009062:Mouth Neoplasms / Q000821:virology*; D012463:Saliva / Q000737:chemistry / Q000821:virology*; D055815:Young Adult
chemical_list: D004279:DNA, Viral
references.citation: J Oral Pathol Med. 2012 Mar;41(3):249-54
references.pmid: 21981060
references.citation: J Oral Pathol Med. 2015 Jan;44(1):28-36
references.pmid: 25040496
references.citation: J Oral Pathol Med. 2015 Apr;44(4):252-7
references.pmid: 25169715
references.citation: Oral Dis. 2009 Nov;15(8):554-9
references.pmid: 19527448
references.citation: Oral Oncol. 2011 Sep;47(9):879-82
references.pmid: 21767975
references.citation: Clin Oral Investig. 2012 Apr;16(2):659-64
references.pmid: 22186943
references.citation: J Periodontal Res. 2006 Aug;41(4):235-44
references.pmid: 16827715
references.citation: Clin Oral Investig. 2015 Mar;19(2):535-43
references.pmid: 24802631
references.citation: J Infect Dis. 2014 Jan 15;209(2):255-64
references.pmid: 23935199
references.citation: JAMA Dermatol. 2013 May;149(5):565-9
references.pmid: 23426332
references.citation: J Investig Clin Dent. 2014 May;5(2):104-8
references.pmid: 24574317
references.citation: Med Oral Patol Oral Cir Bucal. 2008 Feb;13(2):E110-3
references.pmid: 18223526
references.citation: Arch Virol. 2013 Jun;158(6):1221-6
references.pmid: 23381395
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Nov;118(5):566-572.e1
references.pmid: 25442493
references.citation: Microbes Infect. 2014 May;16(5):371-8
references.pmid: 24613199
references.citation: Ann N Y Acad Sci. 1993 Sep 20;694:72-7
references.pmid: 8215087
references.citation: J Periodontol. 2011 Oct;82(10):1442-52
references.pmid: 21563945
references.citation: Transplant Proc. 2011 Mar;43(2):540-2
references.pmid: 21440755
references.citation: Med Oral Patol Oral Cir Bucal. 2013 May;18(3):e411-3
references.pmid: 23524439
references.citation: Int J Dermatol. 2013 Jul;52(7):887-90
references.pmid: 23789606
references.citation: Oral Microbiol Immunol. 2009 Aug;24(4):340-2
references.pmid: 19572898
references.citation: J Virol. 2013 Jul;87(14):8179-94
references.pmid: 23698302
references.citation: Int J Prev Med. 2014 Oct;5(10):1231-8
references.pmid: 25400880