title: Experimental and computational study of membrane affinity for selected energetic compounds.
abstract: The affinity of various energetic compounds for a biological membrane was investigated using experimental and computational techniques. We measured octanol-water (log(Kow)) and liposome-water (log(Klipw)) partition coefficients for the following chemicals: trinitrotoluene (TNT), 2,4-dinitrotoluene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT), 2,4-dinitroanisole (DNAN), 2methoxy-5-nitrophenol (2M5NP), 2,4,6-trinitrobenzene (TNB), and 2,4-dinitrophenol (2,4-DNP). In order to determine log(Klipw) experimentally, we used artificial solid supported lipid liposomes produced under trade mark TRANSIL. Log(Kow) value were predicted with several program packages including the COSMOthermX software. Log(Klipw) were estimated with COSMOmic as implemented in the COSMOthermX program package. In order to verify accuracy of our experimentally obtained results, we performed basic statistical analysis of data taken from the literature. We concluded that compounds considered in this study possess a moderate ability to penetrate into membranes. Comparison of both coefficients has shown that in general, the log(Kow) values are slightly smaller than log(Klipw).
authors.affiliation: Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, USA.
authors.forename: Anastasiia
authors.initials: A
authors.lastname: Golius
authors.affiliation: HX5, LLC, Vicksburg, MS, USA.
authors.forename: Leonid
authors.initials: L
authors.lastname: Gorb
authors.affiliation: U.S. Army Engineer Research and Development Center, Vicksburg, MS, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Michalkova Scott
authors.affiliation: U.S. Army Engineer Research and Development Center, Vicksburg, MS, USA.
authors.forename: Frances C
authors.initials: FC
authors.lastname: Hill
authors.affiliation: U.S. Army Engineer Research and Development Center, Vicksburg, MS, USA.
authors.forename: Manoj
authors.initials: M
authors.lastname: Shukla
authors.affiliation: iMedDo, Inc, P.O Box 137103, Fort Worth, TX, 76136, USA.
authors.forename: A Benjamin
authors.initials: AB
authors.lastname: Goins
authors.affiliation: Conostoga-Rovers & Associates, Dallas, TX, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Johnson
authors.affiliation: Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, USA. Electronic address: jerzy@icnanotox.org.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Leszczynski
mesh_terms: D004785:Environmental Pollutants / Q000737:chemistry*; D004787:Environmental Pollution / Q000517:prevention & control*; D008081:Liposomes / Q000737:chemistry*; D008567:Membranes, Artificial; D008962:Models, Theoretical; D009578:Nitrobenzenes / Q000737:chemistry; D009596:Nitrophenols / Q000737:chemistry; D000442:Octanols / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D004785:Environmental Pollutants; D008081:Liposomes; D008567:Membranes, Artificial; D009578:Nitrobenzenes; D009596:Nitrophenols; D000442:Octanols; D014867:Water
keywords: Artificial bilayer lipid membranes; Energetic compounds; Partition coefficient; Theoretical study