title: Quality of life changes over time in patients with chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  Chronic obstructive pulmonary disease (COPD) is often considered to be a disease in which an inevitable decline in lung function results in increasing dyspnea and deteriorating quality of life. This review summarizes recent data that calls this classic paradigm into question. Studies evaluating the effects of chronic sputum production, physical activity, and inhaled medications on quality of life and prognosis are also discussed.
  
  
  RESULTS
  Chronic sputum production and level of dyspnea contribute at least as much to impairment of quality of life and prognosis as does abnormal lung function. An accelerated decline in FEV1 occurs in only half of the patients who develop COPD. Current pharmacotherapy has been shown to moderate disease progression and quality of life, although the effects are lost when inhaled corticosteroids are discontinued. Declining physical activity begins early in the course of COPD, but increasing activity levels result in improved quality of life and a slower decline in lung function.
  
  
  CONCLUSIONS
  Symptoms and activity levels are as important as measuring FEV1 in determining disease severity, quality of life, and prognosis of COPD. Therapies exist that moderate the course of the disease, and small sustained increases in physical activity may slow physical deterioration and improve health-related quality of life.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern at Dallas, Dallas, Texas.
authors.forename: Gary L
authors.initials: GL
authors.lastname: Jones
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D018450:Disease Progression; D004417:Dyspnea; D006801:Humans; D009043:Motor Activity; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000503:physiopathology; D011788:Quality of Life
chemical_list: D000305:Adrenal Cortex Hormones