title: Antioxidative-oxidative balance in epilepsy patients on antiepileptic therapy: a prospective case-control study.
abstract: Oxidative stress has been implicated in various disorders, including epilepsy. The aim of this study was to investigate the oxidant and antioxidant status of patients with epilepsy using antiepileptic drugs regularly and to compare them with healthy subjects. We investigated serum catalase (CAT), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and xanthine oxidase (XO) levels in 58 epilepsy patients and 25 healthy controls. Patients were divided into polytherapy (n = 17) and monotherapy (n = 41) groups, and antioxidant status was compared between the two groups and controls. There was no significant difference between the patient and control groups in terms of age or gender (p > 0.05). The mean duration of illness in the patients was 14.8 years, and the mean duration of treatment was 11.4 years. Comparison of the patient and control groups in terms of oxidative stress and antioxidant defence parameters revealed significantly higher MDA, GSH-Px, XO and lower level of CAT, SOD levels (p < 0.05). There were no differences in CAT, MDA, GSH-Px or SOD levels between the monotherapy and polytherapy groups; but the XO level was higher in the monotherapy group (p < 0.05). Although the XO level was decreased by polytherapy, it was higher than in controls. Our study found significantly low level of antioxidants in patients with epilepsy as compared to control. Thus, antiepileptic treatment did not improve oxidative stress parameters. Furthermore, our results show that polytherapy does not change the situation as compared with monotherapy. Antioxidant replacement therapy may benefit these patients.
authors.affiliation: Department of Adult Neurology, Ankara Training and Research Hospital, Şükriye District, Ulucanlar Avenue, No: 89, Altındağ, 06340, Ankara, Turkey. keskinselda@gmail.com.
authors.forename: Selda
authors.initials: S
authors.lastname: Keskin Guler
authors.affiliation: General Directorate of Health Information Systems, Ministry of Health, Ankara, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Aytac
authors.affiliation: The Laboratory of Turkish Public Health Institution, Ministry of Health, Ankara, Turkey.
authors.forename: Zahide Esra
authors.initials: ZE
authors.lastname: Durak
authors.affiliation: Department of Adult Neurology, Ankara Training and Research Hospital, Şükriye District, Ulucanlar Avenue, No: 89, Altındağ, 06340, Ankara, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Gokce Cokal
authors.affiliation: Department of Adult Neurology, Ankara Training and Research Hospital, Şükriye District, Ulucanlar Avenue, No: 89, Altındağ, 06340, Ankara, Turkey.
authors.forename: Nalan
authors.initials: N
authors.lastname: Gunes
authors.affiliation: Department of Biochemistry, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Durak
authors.affiliation: Department of Adult Neurology, Ankara Training and Research Hospital, Şükriye District, Ulucanlar Avenue, No: 89, Altındağ, 06340, Ankara, Turkey.
authors.forename: Tahir
authors.initials: T
authors.lastname: Yoldas
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism* / Q000627:therapeutic use; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D011446:Prospective Studies; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D000975:Antioxidants; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase
keywords: Antiepileptic drugs; Antioxidant effect; Monotherapy; Oxidative balance; Polytherapy
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