title: Genipin-modified gelatin nanocarriers as swelling controlled drug delivery system for in vitro release of cytarabine.
abstract: The aim of the present investigation was to design biocompatible gelatin nanoparticles, capable of releasing the cytarabine drug in a controllable way by regulating the extent of swelling of nanoparticles. In order to achieve the proposed objectives, gelatin (Type A, derived from acid cured tissue) was modified by crosslinking with genipin and nanoparticles of crosslinked gelatin were prepared using single water in oil (W/O) emulsion technique. The nanoparticles were characterized by techniques like FTIR, SEM, TEM, particles size analysis, and surface potential measurements. The nanoparticle chemical architecture was found to influence drug-releasing capacity. The influence of experimental conditions such as pH and simulated physiological fluids as the release medium was also investigated on the release profiles of cytarabine. It is possible to fabricate high-performance materials, by designing of controlled size gelatin nanoparticles with good biocompatible properties along with desired drug release profiles.
authors.affiliation: Department of Chemistry, S.A.T.I., Vidhisha, Madhya Pradesh, India.
authors.forename: Huda
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Chemistry, S.A.T.I., Vidhisha, Madhya Pradesh, India.
authors.forename: R N
authors.initials: RN
authors.lastname: Shukla
authors.affiliation: Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, Madhya Pradesh, India. Electronic address: akbmrl@yahoo.co.in.
authors.forename: A K
authors.initials: AK
authors.lastname: Bajpai
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000737:chemistry* / Q000378:metabolism; D003561:Cytarabine / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005780:Gelatin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D039823:Iridoids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000964:Antimetabolites, Antineoplastic; D004337:Drug Carriers; D039823:Iridoids; D003561:Cytarabine; D005780:Gelatin; C007834:genipin
keywords: Cytarabine; Drug release; Gelatin; Nanocarriers