title: Acidic pH-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microRNA modulation in cancer cells.
abstract: pH-Induced charge-reversal nanoparticles incorporating microRNA (miRNA) were engineered through a single-step self-assembly of polyelectrolyte complexes. We found that the endosomal/lysosomal acidic environment could trigger the charge reversal of the nanoparticles from negative charge to positive charge and induce the structure alteration of the nanoparticles, which in turn led to accelerated endosomal escape and enhanced miRNA modulation in esophageal cancer cells.
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. China. shengwang@bjut.edu.cn and Chinese Academy of Sciences, Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, 100190 Beijing, P. R. China. wuy@nanoctr.cn.
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Deng
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. China. shengwang@bjut.edu.cn.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. China. shengwang@bjut.edu.cn.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. China. shengwang@bjut.edu.cn.
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Yin
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. China. shengwang@bjut.edu.cn.
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. China. shengwang@bjut.edu.cn.
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Xiao
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. China. shengwang@bjut.edu.cn.
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Chinese Academy of Sciences, Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, 100190 Beijing, P. R. China. wuy@nanoctr.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. China. shengwang@bjut.edu.cn.
authors.forename: Wang
authors.initials: W
authors.lastname: Sheng
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. China. shengwang@bjut.edu.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000143:Acids / Q000737:chemistry*; D011992:Endosomes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D035683:MicroRNAs / Q000378:metabolism*; D053758:Nanoparticles; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D000143:Acids; D035683:MicroRNAs