title: Oxidative stress and abdominal aortic aneurysm: potential treatment targets.
abstract: Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress. These have been suggested to promote degradation of the extracellular matrix (ECM) and vascular smooth muscle apoptosis. Experimental and human association studies suggest that ROS can be favourably modified to limit AAA formation and progression. In the present review, we discuss mechanisms potentially linking ROS to AAA pathogenesis and highlight potential treatment strategies targeting ROS. Currently, none of these strategies has been shown to be effective in clinical practice.
authors.affiliation: Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, James Cook Drive, Douglas, Townsville, QLD 4811, Australia Discipline of Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Studies, James Cook University, Townsville, QLD 4811, Australia.
authors.forename: Theophilus I
authors.initials: TI
authors.lastname: Emeto
authors.affiliation: Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, James Cook Drive, Douglas, Townsville, QLD 4811, Australia.
authors.forename: Joseph V
authors.initials: JV
authors.lastname: Moxon
authors.affiliation: Discipline of Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Studies, James Cook University, Townsville, QLD 4811, Australia Department of Internal Medicine, The Townsville Hospital, Townsville, QLD 4814, Australia.
authors.forename: Minnie
authors.initials: M
authors.lastname: Au
authors.affiliation: Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, James Cook Drive, Douglas, Townsville, QLD 4811, Australia Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, QLD 4814, Australia jonathan.golledge@jcu.edu.au.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Golledge
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D017544:Aortic Aneurysm, Abdominal / Q000378:metabolism* / Q000517:prevention & control; D004195:Disease Models, Animal; D019317:Evidence-Based Medicine / Q000379:methods; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species
keywords: abdominal aortic aneurysm; animal models; clinical trial; oxidative stress; pharmacotherapy