title: CUG-binding protein 1 (CUGBP1) expression and prognosis of brain metastases from non-small cell lung cancer.
abstract: BACKGROUND
  The brain is a frequent site of metastases from non-small cell lung cancer (NSCLC). The purpose of this study was to detect the expression of CUG-binding protein 1 (CUGBP1) messenger ribonucleic acid (mRNA) and Ki-67 in metastasized brain tissue from NSCLC and determine the relationship between CUGBP1 and brain metastases.
  
  
  METHODS
  The expression of CUGBP1 mRNA and Ki-67 in metastasized brain tissue from NSCLC was investigated by semiquantitative polymerase chain reaction and immunohistochemistry, respectively. The expression of CUGBP1 and Ki-67 in metastasized brain tissue from NSCLC was related to clinical characteristics, as assessed using the chi-square test. The prognostic significance was assessed by univariate and multivariate analyses using the Cox hazard model.
  
  
  RESULTS
  The expression of CUGBP1 mRNA and Ki-67 was overexpressed in metastasized brain tissue from NSCLC and was correlated with differentiation. In addition, by both univariate and multivariate survival analyses, CUGBP1 expression, Ki-67 expression, and age were noted to be independent indicators of a shorter postsurgical survival.
  
  
  CONCLUSIONS
  The expression of CUGBP1 is an important factor in the development of brain metastases from NSCLC.
authors.affiliation: Department of Thoracic Surgery The Affiliated Hospital of Qingdao University Qingdao China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery The Affiliated Hospital of Qingdao University Qingdao China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Jiao
authors.affiliation: Department of Thoracic Surgery The Affiliated Hospital of Qingdao University Qingdao China.
authors.forename: Yandong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Thoracic Surgery The Affiliated Hospital of Qingdao University Qingdao China.
authors.forename: Liangdong
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery The Affiliated Hospital of Qingdao University Qingdao China.
authors.forename: Ruyong
authors.initials: R
authors.lastname: Yao
authors.affiliation: Department of Thoracic Surgery The Affiliated Hospital of Qingdao University Qingdao China.
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery The Affiliated Hospital of Qingdao University Qingdao China.
authors.forename: Mingzhao
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery The Affiliated Hospital of Qingdao University Qingdao China.
authors.forename: Yiren
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Thoracic Surgery The Affiliated Hospital of Qingdao University Qingdao China.
authors.forename: Jinpeng
authors.initials: J
authors.lastname: Zhao
keywords: Brain metastases; CUGBP1; Ki‐67; non‐small cell lung cancer
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