title: The two fold role of oxytocin in social developmental disorders: A cause and a remedy?
abstract: Oxytocin is widely used by obstetricians to induce or facilitate labor. The long lasting consequences of oxytocin administration remain however unknown. Here, we discuss recent evidence suggesting a link between oxytocin labor induction and developmental social impairments such as autism spectrum disorders (ASD). Because these associations are methodologically questionable, we provide a review of animal studies investigating the long term effects of neonatal injection of oxytocin to shed light on the biological mechanisms that mediate the contribution of early oxytocin supplementation on the development of social impairments. In contrast to this potential negative impact on development, oxytocin has been shown to ameliorate social skills of ASD patients. However, results of chronic oxytocin administration from animal experiments are contradictory. We also review recent studies looking at chronic oxytocin effects in animal and in humans. Obstetric and psychiatric uses of exogenous oxytocin both impact on oxytocinergic neurotransmission but the effects may be sharply dissimilar.
authors.affiliation: Institut des Sciences Cognitives Marc Jeannerod, UMR 5229, CNRS Bron, Université Claude Bernard Lyon 1, Lyon, Fondation Fondamental, Paris, France. Electronic address: Arthur.lefevre@isc.cnrs.fr.
authors.forename: Arthur
authors.initials: A
authors.lastname: Lefevre
authors.affiliation: Institut des Sciences Cognitives Marc Jeannerod, UMR 5229, CNRS Bron, Université Claude Bernard Lyon 1, Lyon, Fondation Fondamental, Paris, France. Electronic address: sirigu@isc.cnrs.fr.
authors.forename: Angela
authors.initials: A
authors.lastname: Sirigu
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000831:Animals, Newborn; D000067877:Autism Spectrum Disorder / Q000139:chemically induced* / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010121:Oxytocin / Q000008:administration & dosage / Q000009:adverse effects* / Q000502:physiology / Q000633:toxicity*; D018045:Receptors, Oxytocin / Q000378:metabolism; D012920:Social Behavior Disorders / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: C569600:OXTR protein, human; D018045:Receptors, Oxytocin; D010121:Oxytocin
keywords: Autism; Early life experience; Labor induction; Oxytocin; Social behavior