title: Evaluation of adjuvant carboplatin chemotherapy in the management of surgically excised anal sac apocrine gland adenocarcinoma in dogs.
abstract: There is no widely accepted standard of care for canine anal sac apocrine gland adenocarcinoma (ASAGAC). Surgery alone is inadequate in many cases, but the benefit of adjuvant chemotherapy is not well established. The primary objective of this retrospective study was to evaluate the role of carboplatin chemotherapy in the post-operative management of ASAGAC. Seventy-four dogs with naturally occurring ASAGAC underwent surgery. Forty-four dogs received adjuvant carboplatin and 30 did not. Median overall survival (OS) was 703 days. Median time to progression (TTP) was 384 days. Only primary tumour size and lymph node metastasis at diagnosis significantly impacted the outcome. Differences in OS and TTP, between the dogs that received adjuvant carboplatin and those that did not, failed to reach statistical significance. Treatment of progressive disease, whilst not limited to chemotherapy, significantly prolonged the survival. This study shows that adjuvant carboplatin chemotherapy is well tolerated and may have a role in the management of dogs with ASAGAC.
authors.affiliation: Department of Medical Sciences, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Wouda
authors.affiliation: Department of Medical Sciences, University of Wisconsin-Madison, Madison, WI, USA.|Instituto Veterinario de Oncologia Comparada (IVOC), Valencia, Spain.|Hospital Clinico Veterinario Universidad Cardenal Herrera-Ceu, Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Borrego
authors.affiliation: Department of Statistics, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: N S
authors.initials: NS
authors.lastname: Keuler
authors.affiliation: Department of Medical Sciences, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: T
authors.initials: T
authors.lastname: Stein
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D000694:Anal Gland Neoplasms / Q000188:drug therapy* / Q000601:surgery; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D005260:Female; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin
keywords: canine; carboplatin; outcome; surgery
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