title: Classification of proteins with shared motifs and internal repeats in the ECOD database.
abstract: Proteins and their domains evolve by a set of events commonly including the duplication and divergence of small motifs. The presence of short repetitive regions in domains has generally constituted a difficult case for structural domain classifications and their hierarchies. We developed the Evolutionary Classification Of protein Domains (ECOD) in part to implement a new schema for the classification of these types of proteins. Here we document the ways in which ECOD classifies proteins with small internal repeats, widespread functional motifs, and assemblies of small domain-like fragments in its evolutionary schema. We illustrate the ways in which the structural genomics project impacted the classification and characterization of new structural domains and sequence families over the decade.
authors.affiliation: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9050.
authors.forename: R Dustin
authors.identifier: 0000-0001-6502-1425
authors.initials: RD
authors.lastname: Schaeffer
authors.affiliation: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9050.
authors.forename: Lisa N
authors.initials: LN
authors.lastname: Kinch
authors.affiliation: Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9050.
authors.forename: Yuxing
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9050.|Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9050.
authors.forename: Nick V
authors.initials: NV
authors.lastname: Grishin
mesh_terms: D020816:Amino Acid Motifs; D030562:Databases, Protein; D019143:Evolution, Molecular; D008958:Models, Molecular; D000072417:Protein Domains; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D040901:Proteomics / Q000379:methods*
chemical_list: D011506:Proteins
keywords: internal; protein classification; protein motifs; repeats; structural bioinformatics; structural genomics
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