title: In vivo at last: Demonstrating the biological credentials and clinical potential of GM-CSF.
abstract: The pioneering contribution of Professor Donald Metcalf, who passed away in 2014, to the discovery and characterisation of the colony-stimulating factors (CSFs) is exemplified by a seminal contribution to Experimental Haematology by Metcalf and colleagues that detailed the in vivo actions of the newly available recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) in 1987. The results described in this publication promoted GM-CSF actions from fascinating in vitro laboratory phenomena to the recognition that this cytokine was a genuine in vivo regulator of blood cell production and function and provided significant impetus for the clinical development of GM-CSF.
authors.affiliation: Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, University of Melbourne, Victoria, Australia. Electronic address: alexandw@wehi.edu.au.
authors.forename: Warren S
authors.initials: WS
authors.lastname: Alexander
mesh_terms: D005197:Famous Persons; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D049673:History, 20th Century; D006801:Humans; D012106:Research / Q000266:history
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor