title: Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institution.
abstract: Treatment and outcome of Hodgkin lymphoma (HL) are the true success story of modern medicine. The data from the developing countries on long-term outcome of patients with HL is sparse.
  
  
  OBJECTIVE
  Primary objective is to assess the progression-free survival (PFS). Secondary objective are overall survival (OS) and toxicities.
  
  
  METHODS
  This is a retrospective analysis from the case records from a single institution.
  
  
  METHODS
  Institutional Ethical Committee approval was obtained. Between January 1991 and December 2010, 301 patients (age ≥18 years) underwent treatment at our institution.
  
  
  METHODS
  Kaplan-Meyer curves were used to calculate the PFS and OS.
  
  
  RESULTS
  The median age at presentation was 36 years, range from 19 to 75 years. The male to female ratio was 2.9:1. Seventy-five percent of patients had B symptoms. Majority presented in advanced stage (Stage III and IV) disease (64.7%). Mixed cellularity (74.4%) was the most common histology, followed by nodular sclerosis (13.9%). The most common chemotherapy regimen used was ABVD (61%).
  
  
  CONCLUSIONS
  Median follow-up of the cohort was 18.5 months (range 2-225). PFS and OS rate at 5 years is 66.3% and 79.7% respectively.
authors.affiliation: Department of Medical Oncology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India.
authors.forename: Rahul Narayan
authors.initials: RN
authors.lastname: Maddi
authors.affiliation: Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Vijay Gandhi
authors.initials: VG
authors.lastname: Linga
authors.affiliation: Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Kalpathi Krishnamani
authors.initials: KK
authors.lastname: Iyer
authors.affiliation: Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Joseph Stalin
authors.initials: JS
authors.lastname: Chowdary
authors.affiliation: Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Sadashivudu
authors.initials: S
authors.lastname: Gundeti
authors.affiliation: Director and Department of Medical Oncology, Tata Memorial Center, Vishakapatnam, Andhra Pradesh, India.
authors.forename: Raghunadharao
authors.initials: R
authors.lastname: Digumarti
authors.affiliation: Department of Pathology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Tara Roshini
authors.initials: TR
authors.lastname: Paul
keywords: Chemotherapy and toxicities; Hodgkin lymphoma; survival
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