title: Evaluation of anterior segment parameters in patients with neurofibromatosis type 1.
abstract: OBJECTIVE
  To evaluate anterior segment parameters in patients with neurofibromatosis type 1 (NF1) in comparison to healthy individuals.
  
  
  METHODS
  A total of 34 eyes from 17 patients with NF1 and 34 eyes from 17 age- and sex-matched healthy individuals were included in this study. Each participant underwent a comprehensive ophthalmic assessment including best-corrected visual acuity, slit-lamp biomicroscopy, stereoscopic fundus examination, and intraocular pressure. Central corneal thickness, corneal volume, corneal curvatures (K1 and K2), anterior chamber depth, anterior chamber volume, iridocorneal angle, and pupil size values were measured by Pentacam Scheimpflug camera.
  
  
  RESULTS
  The mean anterior chamber depth, iridocorneal angle, and anterior chamber volume measurements revealed signiﬁcantly lower values when compared with the control group (p&lt;0.001, p&lt;0.001, and p = 0.041, respectively). However, the mean pupil size was significantly larger when compared with the control group (p = 0.008). Central corneal thickness, corneal volume, K1, and K2 values were similar between the study and control groups (p = 0.875, p = 0.549, p = 0.066, and p = 0.166, respectively).
  
  
  CONCLUSIONS
  Our results reveal that NF1 is associated with statistically signiﬁcant alterations in anterior chamber depth, iridocorneal angle, anterior chamber volume, and pupil size in patients with NF1 when compared with healthy controls.
authors.affiliation:  Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri - Turkey.
authors.forename: Necati
authors.initials: N
authors.lastname: Duru
authors.affiliation:  Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri - Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Göktaş
authors.affiliation:  Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri - Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Özköse
authors.affiliation:  Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri - Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Duru
authors.affiliation:  Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri - Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Altunel
authors.affiliation:  Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri - Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ataş
authors.affiliation:  Department of Dermatology, Kayseri Education and Research Hospital, Kayseri - Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Özlü
mesh_terms: D000293:Adolescent; D000328:Adult; D000869:Anterior Eye Segment / Q000473:pathology*; D003430:Cross-Sectional Studies; D005128:Eye Diseases / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000503:physiopathology; D066167:Slit Lamp; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult