title: Persistence of the immune response after MenACWY-CRM vaccination and response to a booster dose, in adolescents, children and infants.
abstract: Persistence of bactericidal antibodies following vaccination is extremely important for protection against invasive meningococcal disease, given the epidemiology and rapid progression of meningococcal infection. We present an analysis of antibody persistence and booster response to MenACWY-CRM, in adolescents, children and infants, from 7 clinical studies. Immunogenicity was assessed using the serum bactericidal assay with both human and rabbit complement. Post-vaccination hSBA titers were high, with an age- and serogroup-specific decline in titers up to 1 y and stable levels up to 5 y The waning of hSBA titers over time was more pronounced among infants and toddlers and the greatest for serogroup A. However, rSBA titers against serogroup A were consistently higher and showed little decline over time, suggesting that protection against this serogroup may be sustained. A single booster dose of MenACWY-CRM administered at 3 to 5 y induced a robust immune response in all age groups.
authors.affiliation: a Kaiser Permanente Vaccine Study Center , Oakland , CA , USA.
authors.forename: Roger
authors.initials: R
authors.lastname: Baxter
authors.affiliation: b GlaxoSmithKline B.V. , Amsterdam , The Netherlands.
authors.forename: Pavitra
authors.initials: P
authors.lastname: Keshavan
authors.affiliation: c GlaxoSmithKline LLC , Cambridge , MA , USA.
authors.forename: Jo Anne
authors.initials: JA
authors.lastname: Welsch
authors.affiliation: c GlaxoSmithKline LLC , Cambridge , MA , USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Han
authors.affiliation: b GlaxoSmithKline B.V. , Amsterdam , The Netherlands.
authors.forename: Igor
authors.initials: I
authors.lastname: Smolenov
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D000068456:Clinical Studies as Topic; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D000071497:Immunogenicity, Vaccine; D007223:Infant; D008297:Male; D008589:Meningococcal Infections / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D009345:Neisseria meningitidis / Q000276:immunology*; D065288:Serogroup; D058248:Serum Bactericidal Antibody Assay; D013997:Time Factors; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; C525703:MenACWY; D022401:Meningococcal Vaccines; D018074:Vaccines, Conjugate
keywords: MenACWY-CRM; booster; hSBA; meningococcal; persistence; rSBA
references.citation: Infect Immun. 2003 Oct;71(10 ):5549-55
references.pmid: 14500473
references.citation: Hum Vaccin Immunother. 2016;12 (1):132-9
references.pmid: 26575983
references.citation: Lancet. 2014 Jan 4;383(9911):40-7
references.pmid: 24035220
references.citation: Infect Immun. 2001 Mar;69(3):1568-73
references.pmid: 11179328
references.citation: Clin Vaccine Immunol. 2009 Dec;16(12):1810-5
references.pmid: 19812260
references.citation: J Exp Med. 1969 Jun 1;129(6):1307-26
references.pmid: 4977280
references.citation: Vaccine. 2005 May 31;23(29):3762-74
references.pmid: 15893613
references.citation: Lancet Infect Dis. 2010 Dec;10(12):853-61
references.pmid: 21075057
references.citation: Clin Diagn Lab Immunol. 2003 Sep;10(5):780-6
references.pmid: 12965904
references.citation: Pediatr Infect Dis J. 2014 Nov;33(11):1169-76
references.pmid: 24911896
references.citation: Clin Diagn Lab Immunol. 1997 Mar;4(2):156-67
references.pmid: 9067649
references.citation: Int J Infect Dis. 2013 Mar;17(3):e173-6
references.pmid: 23246368
references.citation: Pediatr Infect Dis J. 2005 Jan;24(1):57-62
references.pmid: 15665711
references.citation: Int J Infect Dis. 2014 Sep;26:22-30
references.pmid: 24980467
references.citation: Vaccine. 2015 Apr 27;33(18):2175-82
references.pmid: 25744224
references.citation: Hum Vaccin Immunother. 2012 Dec 1;8(12):1892-903
references.pmid: 23032159
references.citation: J Infect Dis. 2006 Dec 15;194(12 ):1745-52
references.pmid: 17109348
references.citation: Clin Infect Dis. 2006 Dec 1;43(11):1387-94
references.pmid: 17083009
references.citation: Vaccine. 2007 Sep 3;25 Suppl 1:A63-8
references.pmid: 17544550
references.citation: Pediatr Infect Dis J. 2012 Jan;31(1):64-71
references.pmid: 22094635
references.citation: JAMA. 2008 Jan 9;299(2):173-84
references.pmid: 18182599
references.citation: MMWR Recomm Rep. 2013 Mar 22;62(RR-2):1-28
references.pmid: 23515099
references.citation: J Pediatr. 2014 Jun;164(6):1409-15.e4
references.pmid: 24657122
references.citation: Pediatr Infect Dis J. 2013 Jul;32(7):760-7
references.pmid: 23348814
references.citation: Pediatr Infect Dis J. 2013 Apr;32(4):e170-7
references.pmid: 23114372
references.citation: BMC Infect Dis. 2014 Dec 04;14:663
references.pmid: 25472422
references.citation: Pediatr Infect Dis J. 2016 Jan;35(1):e19-27
references.pmid: 26398741
references.citation: Vaccine. 2015 Aug 26;33(36):4414-21
references.pmid: 26187262
references.citation: BMC Infect Dis. 2013 Mar 05;13:116
references.pmid: 23510357
references.citation: J Exp Med. 1969 Jun 1;129(6):1327-48
references.pmid: 4977281
references.citation: Expert Rev Vaccines. 2006 Apr;5(2):269-75
references.pmid: 16608426
references.citation: Clin Vaccine Immunol. 2008 May;15(5):799-804
references.pmid: 18353918
references.citation: Vaccine. 2010 Nov 23;28(50):7865-72
references.pmid: 20943209
references.citation: Clin Vaccine Immunol. 2009 Jul;16(7):969-77
references.pmid: 19474264
references.citation: Infect Immun. 2004 Oct;72(10):5903-9
references.pmid: 15385492
references.citation: Hum Vaccin. 2010 Nov;6(11):881-7
references.pmid: 21339701
references.citation: Vaccine. 2009 Jun 24;27 Suppl 2:B51-63
references.pmid: 19477562
references.citation: Pediatr Infect Dis J. 2006 Nov;25(11):995-1000
references.pmid: 17072120
references.citation: Vaccine. 2015 Mar 10;33(11):1317-23
references.pmid: 25662856
references.citation: Vaccine. 2005 Mar 18;23(17-18):2222-7
references.pmid: 15755600
references.citation: Pediatr Infect Dis J. 2015 Nov;34(11):1236-43
references.pmid: 26237742
references.citation: Infect Immun. 2001 May;69(5):3203-13
references.pmid: 11292742
references.citation: Vaccine. 2013 Sep 23;31(41):4477-86
references.pmid: 23933336
references.citation: Clin Vaccine Immunol. 2009 Jun;16(6):785-91
references.pmid: 19339487
references.citation: Vaccine. 2005 Mar 18;23(17-18):2214-7
references.pmid: 15755598