title: The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery.
abstract: The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs offers a paradigm shift in plastic and reconstructive surgery. The use of either embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) in clinical situations is limited because of regulations and ethical considerations even though these cells are theoretically highly beneficial. Adult mesenchymal stem cells appear to be an ideal stem cell population for practical regenerative medicine. Among these cells, adipose-derived stem cells (ADSC) have the potential to differentiate the mesenchymal, ectodermal and endodermal lineages and are easy to harvest. Additionally, adipose tissue yields a high number of ADSC per volume of tissue. Based on this background knowledge, the purpose of this review is to summarise and describe the proliferation and differentiation capacities of ADSC together with current preclinical data regarding the use of ADSC as regenerative tools in plastic and reconstructive surgery.
authors.affiliation: Reconstructive Surgery & Regenerative Medicine Group, Institute of Life Sciences (ILS), Swansea University Medical School, Swansea, UK.|Welsh Centre for Burns & Plastic Surgery, ABMU Health Board, Swansea, UK.
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Naderi
authors.affiliation: Reconstructive Surgery & Regenerative Medicine Group, Institute of Life Sciences (ILS), Swansea University Medical School, Swansea, UK.|Welsh Centre for Burns & Plastic Surgery, ABMU Health Board, Swansea, UK.
authors.forename: Emman J
authors.initials: EJ
authors.lastname: Combellack
authors.affiliation: UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Griffin
authors.affiliation: UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Tina
authors.initials: T
authors.lastname: Sedaghati
authors.affiliation: Reconstructive Surgery & Regenerative Medicine Group, Institute of Life Sciences (ILS), Swansea University Medical School, Swansea, UK.|Welsh Centre for Burns & Plastic Surgery, ABMU Health Board, Swansea, UK.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Javed
authors.affiliation: Plastic & Reconstructive Surgery, Stanford University Medical Centre, Stanford, CA, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Findlay
authors.affiliation: Plastic & Reconstructive Surgery, Royal Devon & Exeter Hospital, Exeter, UK.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Wallace
authors.affiliation: UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.|Department of Plastic Surgery, Royal Free NHS Foundation Trust, London, UK.
authors.forename: Afshin
authors.initials: A
authors.lastname: Mosahebi
authors.affiliation: Department of Plastic Surgery, Royal Free NHS Foundation Trust, London, UK.
authors.forename: Peter Em
authors.initials: PE
authors.lastname: Butler
authors.affiliation: UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Seifalian
authors.affiliation: Reconstructive Surgery & Regenerative Medicine Group, Institute of Life Sciences (ILS), Swansea University Medical School, Swansea, UK.|Welsh Centre for Burns & Plastic Surgery, ABMU Health Board, Swansea, UK.
authors.forename: Iain S
authors.initials: IS
authors.lastname: Whitaker
mesh_terms: D000273:Adipose Tissue / Q000254:growth & development*; D000818:Animals; D006801:Humans; D019651:Plastic Surgery Procedures / Q000379:methods*; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology*; D013518:Surgery, Plastic / Q000379:methods*
keywords: ADSC; Reconstructive surgery; Stem cells; Tissue engineering
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