title: Actin flows in cell migration: from locomotion and polarity to trajectories.
abstract: Eukaryotic cell movement is characterized by very diverse migration modes. Recent studies show that cells can adapt to environmental cues, such as adhesion and geometric confinement, thereby readily switching their mode of migration. Among this diversity of motile behavior, actin flows have emerged as a highly conserved feature of both mesenchymal and amoeboid migration, and have also been identified as key regulators of cell polarity. This suggests that the various observed migration modes are continuous variations of elementary locomotion mechanisms, based on a very robust physical property of the actin/myosin system - its ability to sustain flows at the cell scale. This central role of actin/myosin flows is shown to affect the large scale properties of cell trajectories.
authors.affiliation: Laboratoire Matiere et Systeme Complexes, CNRS/Universite Paris-Diderot, UMR 7057, 75205 Paris cedex 13, France.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Callan-Jones
authors.affiliation: Laboratoire Jean Perrin, UMR 8237 CNRS/UPMC, 4 Place Jussieu, 75255 Paris Cedex, France. Electronic address: voiturie@lptmc.jussieu.fr.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Voituriez
mesh_terms: D000199:Actins / Q000378:metabolism*; D002465:Cell Movement; D016764:Cell Polarity; D009218:Myosins / Q000378:metabolism
chemical_list: D000199:Actins; D009218:Myosins