title: Maackiapterocarpan B from Sophora tonkinensis Suppresses Inflammatory Mediators via Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathways.
abstract: Maackiapterocarpan B, one of the pterocarpan analogs found in Sophora tonkinensis, is known to display pharmacological activities. However, the anti-inflammatory effects of maackiapterocarpan B and its molecular mechanism have yet to be clearly elucidated. In the present study, the effects of maackiapterocarpan B on macrophage-mediated inflammation in vitro were assessed. Maackiapterocarpan B inhibited the production of nitric oxide, the expression of tumor necrosis factor α, colony stimulating factor 2, interleukin-1β and interleukin-6, and the activation of nuclear factor-κB and mitogen-activated protein kinases in lipopolysaccharide-stimulated macrophages. These observations suggest the potential of maackiapterocarpan B in the treatment of inflammatory diseases.
authors.affiliation: College of Pharmacy and BK21plus R-Find Team, Dongguk University-Seoul.
authors.forename: Hee-Sung
authors.initials: HS
authors.lastname: Chae
authors.forename: Hunseung
authors.initials: H
authors.lastname: Yoo
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Choi
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Choi
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
mesh_terms: D000818:Animals; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D020935:MAP Kinase Signaling System / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D015394:Molecular Structure; D016328:NF-kappa B; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D036343:Pterocarpans / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D029909:Sophora / Q000737:chemistry*
chemical_list: D016328:NF-kappa B; D036343:Pterocarpans; C000611871:maackiapterocarpan B; D052247:Nitric Oxide Synthase Type II; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2