title: Deciphering the true antiproliferative target of an MK2 activation inhibitor in glioblastoma.
authors.affiliation: Structural Genomics Consortium, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
authors.forename: P E
authors.initials: PE
authors.lastname: Brennan
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects / Q000502:physiology*; D005909:Glioblastoma / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000099190:MAP-Kinase-Activated Kinase 2
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; D000099190:MAP-Kinase-Activated Kinase 2
references.citation: Nat Chem Biol. 2014 Apr;10(4):305-12
references.pmid: 24584101
references.citation: J Proteome Res. 2013 Apr 5;12(4):1723-31
references.pmid: 23495751
references.citation: Nat Chem Biol. 2013 Apr;9(4):195-9
references.pmid: 23508172
references.citation: Mol Pharmacol. 2014 Feb;85(2):345-56
references.pmid: 24296859
references.citation: Cell Death Discov. 2015 Sep 07;1:15028
references.pmid: 27551460
references.citation: J Pharmacol Exp Ther. 2010 Jun;333(3):797-807
references.pmid: 20237073
references.citation: Expert Opin Drug Discov. 2013 Jun;8(6):621-40
references.pmid: 23594139
references.citation: Biochemistry. 2004 Sep 21;43(37):11658-71
references.pmid: 15362850
references.citation: J Med Chem. 2007 May 31;50(11):2647-54
references.pmid: 17480064
references.citation: Nat Chem Biol. 2015 Aug;11(8):536-41
references.pmid: 26196764
references.citation: Drug Discov Today. 2015 May;20(5):505-13
references.pmid: 25582842
references.citation: PLoS One. 2013;8(3):e57888
references.pmid: 23505445
references.citation: Cancer Res. 2013 May 15;73(10):3087-96
references.pmid: 23598276