title: Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles.
abstract: We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control.
authors.affiliation: Department of Chemistry, University of Chicago , Chicago, Illinois 60637, United States.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Montgomery
authors.affiliation: Department of Chemistry, University of Chicago , Chicago, Illinois 60637, United States.
authors.forename: Viresh H
authors.initials: VH
authors.lastname: Rawal
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D010879:Piperazines; D010165:Palladium; D009584:Nitrogen
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