title: Phototherapy induced cutaneous eruption in a neonate with transient porphyrinemia.
abstract: Phototherapy for hyperbilirubinemia has rare complications. We report a case of phototherapy induced eruption in a neonate with transient porphyrinemia. Our patient received phototherapy due to hyperbilirubinemia secondary to erythroblastosis fetalis (hemolytic disease of the newborn). He developed a cutaneous rash in the light-exposed areas of his skin. Erythrocyte and plasma porphyrins were elevated at the time. Phototherapy induced eruption with a transient porphyrinemia is rare. Upon review of the literature, we found only 5 other cases of patients with phototherapy induced rash and elevated porphyrins reported. We compared the five other reported cases to our case, looking at drug exposure, age, and receipt of exchange transfusion.
  
  
  CONCLUSIONS
  While this is an uncommon occurrence, transient porphyrinemia should be considered in neonates with phototherapy induced cutaneous eruption and erythroblastosis fetalis.
authors.affiliation: Division of Hematology/Oncology, Children's Mercy Hospital and Clinics, Kansas City, MO, USA.
authors.forename: M
authors.initials: M
authors.lastname: Villanueva
authors.affiliation: Division of Hematology/Oncology, Children's Mercy Hospital and Clinics, Kansas City, MO, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Fulbright
authors.affiliation: Division of Dermatology, Children's Mercy Hospital and Clinics, Kansas City, MO, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Horii
mesh_terms: D017484:Dermatitis, Phototoxic / Q000209:etiology*; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000628:therapy; D017707:Erythrocyte Transfusion; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood / Q000628:therapy; D007231:Infant, Newborn; D008297:Male; D010789:Phototherapy / Q000009:adverse effects*; D011166:Porphyrins / Q000097:blood*
chemical_list: D011166:Porphyrins