title: Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis.
abstract: Acute pancreatitis is an inflammatory process originated in the pancreas; however, it often leads to systemic complications that affect distant organs. Acute respiratory distress syndrome is indeed the predominant cause of death in patients with severe acute pancreatitis. In this study, we aimed to delineate the ameliorative effect of dihydro-resveratrol, a prominent analog of trans-resveratrol, against acute pancreatitis-associated lung injury and the underlying molecular actions. Acute pancreatitis was induced in rats with repetitive injections of cerulein (50 µg/kg/h) and a shot of lipopolysaccharide (7.5 mg/kg). By means of histological examination and biochemical assays, the severity of lung injury was assessed in the aspects of tissue damages, myeloperoxidase activity, and levels of pro-inflammatory cytokines. When treated with dihydro-resveratrol, pulmonary architectural distortion, hemorrhage, interstitial edema, and alveolar thickening were significantly reduced in rats with acute pancreatitis. In addition, the production of pro-inflammatory cytokines and the activity of myeloperoxidase in pulmonary tissues were notably repressed. Importantly, nuclear factor-kappaB (NF-κB) activation was attenuated. This study is the first to report the oral administration of dihydro-resveratrol ameliorated acute pancreatitis-associated lung injury via an inhibitory modulation of pro-inflammatory response, which was associated with a suppression of the NF-κB signaling pathway.
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.|School of Fundamental Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Ze-Si
authors.initials: ZS
authors.lastname: Lin
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.
authors.forename: Chuen Fai
authors.initials: CF
authors.lastname: Ku
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.
authors.forename: Yi-Fu
authors.initials: YF
authors.lastname: Guan
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Xiao
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.
authors.forename: Xiao-Ke
authors.initials: XK
authors.lastname: Shi
authors.affiliation: School of Fundamental Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Hong-Qi
authors.initials: HQ
authors.lastname: Wang
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.
authors.forename: Zhao-Xiang
authors.initials: ZX
authors.lastname: Bian
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.|Institute of Research and Continuing Education, Hong Kong Baptist University Shenzhen Research Center, Shenzhen, China.
authors.forename: Siu Wai
authors.initials: SW
authors.lastname: Tsang
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002108:Ceruletide / Q000009:adverse effects; D016207:Cytokines / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008171:Lung Diseases / Q000150:complications / Q000188:drug therapy*; D016328:NF-kappa B / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects; D010195:Pancreatitis / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology*; D000516:alpha-Amylases / Q000097:blood
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D013267:Stilbenes; D002108:Ceruletide; D009195:Peroxidase; D000516:alpha-Amylases; D000077185:Resveratrol
keywords: acute pancreatitis; acute pancreatitis-associated lung injury; cerulein; dihydro-resveratrol; pro-inflammatory cytokines; trans-resveratrol