title: Decreased visceral fat area correlates with improved arterial stiffness after Roux-en-Y gastric bypass in Chinese obese patients with type 2 diabetes mellitus: a 12-month follow-up.
abstract: BACKGROUND
  Associations between demographic data and arterial stiffness have not been examined adequately in Chinese obese patients with type 2 diabetes (T2DM) who underwent Roux-en-Y gastric bypass (RYGB).
  
  
  OBJECTIVE
  This study was designed to examine changes in body fat distribution and metabolic parameters after RYGB and whether these changes correlated with improved arterial stiffness.
  
  
  METHODS
  The study was performed at the authors' academic university-affiliated hospital.
  
  
  METHODS
  A retrospective review of 42 Chinese patients with a diagnosis of obesity and T2DM and 22 health controls was conducted, focusing on metabolic outcomes and aortic pulse wave velocity (PWV) before and 12 months after RYGB.
  
  
  RESULTS
  At baseline, PWV in the study group was significantly greater than in the control group (6.9±1.5 versus 5.8±.6 ms, respectively; P<.01). PWV was negatively correlated with age, systolic blood pressure, diastolic blood pressure, visceral fat area (VFA), and leptin level (r = .47, P<.01; r = .39, P<.01; r = .31, P = .03; r = .47, P<.01; and r = .30, P = .03, respectively). Multiple stepwise regression found that age and VFA were independently associated with PWV (β = .40, P<.01; β = .30, P = .02, respectively). PWV, body mass index, VFA, and metabolic profiles all improved significantly 12 months after RYGB. The change in PWV was positively correlated with changes in VFA and the leptin level (r = .40, P = .03; r = .40, P = .02, respectively).
  
  
  CONCLUSIONS
  Decreased VFA resulting from RYGB correlated with improved arterial stiffness in obese Chinese patients with T2DM. Leptin might be an important factor linking PWV and visceral fat accumulation.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Haoyong
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Ultrasound, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Junxi
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Yinfang
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Pin
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address: wpjia@sjtu.edu.cn.
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D050152:Intra-Abdominal Fat / Q000473:pathology; D020738:Leptin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000208:ethnology / Q000503:physiopathology / Q000601:surgery*; D061646:Operative Time; D012189:Retrospective Studies; D059289:Vascular Stiffness / Q000502:physiology
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; D020738:Leptin
keywords: Gastric bypass; Intra-abdominal fat; Leptin; Obesity; Vascular stiffness