title: Production of Virus-Like Particles for Vaccination.
abstract: The ability to make a large variety of virus-like particles (VLPs) has been successfully achieved in the baculovirus expression vector system (BEVS)/insect cell system. The production and scale-up of these particles, which are mostly sought as vaccine candidates, are currently being addressed. Furthermore, these VLPs are being investigated as delivery agents for use as therapeutics. The use of host insect cells allows mass production of VLPs in a proven scalable system.
authors.affiliation: Department of Chemical Engineering, Ecole Polytechnique de Montreal, 2500, Chemin de Polytechnique, Montreal, QC, Canada.|National Research Council Canada, Montreal, QC, Canada.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Thompson
authors.affiliation: Department of Chemical Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON, Canada, N2L 3G1. marc.aucoin@uwaterloo.ca.
authors.forename: Marc G
authors.initials: MG
authors.lastname: Aucoin
authors.affiliation: National Research Council Canada, Montreal, QC, Canada.|Department of Bioengineering, McGill University, Montreal, QC, Canada.
authors.forename: Amine A
authors.initials: AA
authors.lastname: Kamen
mesh_terms: D000818:Animals; D016367:Baculoviridae / Q000235:genetics; D019149:Bioreactors / Q000821:virology; D046508:Culture Techniques; D004591:Electrophoresis, Polyacrylamide Gel; D005818:Genetic Engineering / Q000379:methods*; D008854:Microscopy, Electron; D061987:Sf9 Cells; D018411:Spodoptera; D013194:Staining and Labeling; D014611:Vaccination; D058425:Vaccines, Virus-Like Particle / Q000096:biosynthesis* / Q000235:genetics* / Q000276:immunology
chemical_list: D058425:Vaccines, Virus-Like Particle
keywords: Baculovirus; Insect cells; VLP; Viral vector; Virus-like particle