title: Copper-Catalyzed N-Arylation of Azoles and Mannich-Type Coupling of Ketones and Azoles under Metal-Free Conditions.
abstract: A new process has been developed for the copper-catalyzed direct N-arylation of five-membered heterocycles with azoles. Five-membered heterocycles bearing an acetyl group also underwent a Mannich-type reaction with activated azoles to give the corresponding β-amino ketones under metal-free conditions. These reactions exhibited wide substrate scope, high functional group tolerance, and ease of operation, making them useful tools with numerous potential applications in synthetic chemistry.
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Zhonghong
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Sun
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University , Anyang 455000, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang