title: Computer Modelling for Better Diagnosis and Therapy of Patients by Cardiac Resynchronisation Therapy.
abstract: Mathematical or computer models have become increasingly popular in biomedical science. Although they are a simplification of reality, computer models are able to link a multitude of processes to each other. In the fields of cardiac physiology and cardiology, models can be used to describe the combined activity of all ion channels (electrical models) or contraction-related processes (mechanical models) in potentially millions of cardiac cells. Electromechanical models go one step further by coupling electrical and mechanical processes and incorporating mechano-electrical feedback. The field of cardiac computer modelling is making rapid progress due to advances in research and the ever-increasing calculation power of computers. Computer models have helped to provide better understanding of disease mechanisms and treatment. The ultimate goal will be to create patient-specific models using diagnostic measurements from the individual patient. This paper gives a brief overview of computer models in the field of cardiology and mentions some scientific achievements and clinical applications, especially in relation to cardiac resynchronisation therapy (CRT).
authors.affiliation: Department of Biomedical Engineering, Cardiovascular Research Institute, Maastricht, The Netherlands;
authors.forename: Marieke
authors.initials: M
authors.lastname: Pluijmert
authors.affiliation: Department of Biomedical Engineering, Cardiovascular Research Institute, Maastricht, The Netherlands;
authors.forename: Joost
authors.initials: J
authors.lastname: Lumens
authors.affiliation: Centre for Computational Medicine in Cardiology, Universita della Svizzera Intaliana, Lugano, Switzerland;
authors.forename: Mark
authors.initials: M
authors.lastname: Potse
authors.affiliation: Department of Biomedical Engineering, Cardiovascular Research Institute, Maastricht, The Netherlands;
authors.forename: Tammo
authors.initials: T
authors.lastname: Delhaas
authors.affiliation: Centre for Computational Medicine in Cardiology, Universita della Svizzera Intaliana, Lugano, Switzerland;; Fondazione Cardiocentro Ticino, Lugano, Switzerland;
authors.forename: Angelo
authors.initials: A
authors.lastname: Auricchio
authors.affiliation: Department of Physiology, Cardiovascular Research Institute, Maastricht, The Netherlands.
authors.forename: Frits W
authors.initials: FW
authors.lastname: Prinzen
keywords: Computer model; bidomain model; cardiac resynchronisation therapy; finite element model; heart failure; monodomain model
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