title: Direct oral anticoagulants: New drugs with practical problems. How can nurses help prevent patient harm?
abstract: The safe use of anticoagulants requires a delicate balance between the risk of bleeding and the risk of thrombosis, particularly in drug-sensitive patients, such as older people. Recently-marketed "direct oral anticoagulants" are now being increasingly prescribed and administered in the hospital setting. Direct oral anticoagulants have pharmacological properties that are often unpredictable, and inter-patient variability in drug response is high. Therefore, people often require meticulous review and planning to ensure they receive optimal dosing and monitoring. The multidisciplinary medication management of those receiving these drugs needs to be effectively coordinated to reduce the risk of patient harm. All clinical staff, including nurses, doctors, and pharmacists, should be competent in the pharmacology of these drugs, and know which people require individualized care plans. In this study, we introduced important concepts via the use of case studies developed from commonly-seen scenarios at our quaternary hospital. In particular, the important role of nurses in ensuring patient safety in the periprocedural setting is highlighted.
authors.affiliation: Department of Pharmacy Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.|Pharmacy Australia Centre of Excellence, University ofQueensland, Brisbane, Queensland, Australia.
authors.forename: Michael A
authors.identifier: http://orcid.org/0000-0001-8105-0090
authors.initials: MA
authors.lastname: Barras
authors.affiliation: Department of Pharmacy Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Hughes
authors.affiliation: Department of Nursing, Surgical and Perioperative services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors.forename: Melanie
authors.initials: M
authors.lastname: Ullner
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use*; D001315:Australia; D016022:Case-Control Studies; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008508:Medication Errors / Q000517:prevention & control; D009726:Nurses; D064406:Patient Harm / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants
keywords: adverse drug event; anticoagulant; deprescribing; hospital; medication safety; nurse; pharmacology