title: Antibody markers in the diagnosis of inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic intestinal inflammation of unknown etiology. The diagnosis of IBD is based on endoscopic, radiologic and histopathologic criteria. Recently, the search for a noninvasive marker that could augment or replace part of this diagnostic process has become a focus of IBD research. In this review, antibody markers, including microbial antibodies, autoantibodies and peptide antibodies, will be described, focusing on their common features. At present, no single marker with qualities that are satisfactory for the diagnosis and treatment of IBD has been identified, although panels of some antibodies are being evaluated with keen interest. The discovery of novel IBD-specific and sensitive markers is anticipated. Such markers could minimize the use of endoscopic and radiologic examinations and could enable clinicians to implement individualized treatment plans designed to improve the long-term prognosis of patients with IBD.
authors.affiliation: Keiichi Mitsuyama, Inflammatory Bowel Disease Center, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Mitsuyama
authors.affiliation: Keiichi Mitsuyama, Inflammatory Bowel Disease Center, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Niwa
authors.affiliation: Keiichi Mitsuyama, Inflammatory Bowel Disease Center, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takedatsu
authors.affiliation: Keiichi Mitsuyama, Inflammatory Bowel Disease Center, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamasaki
authors.affiliation: Keiichi Mitsuyama, Inflammatory Bowel Disease Center, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Kuwaki
authors.affiliation: Keiichi Mitsuyama, Inflammatory Bowel Disease Center, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yoshioka
authors.affiliation: Keiichi Mitsuyama, Inflammatory Bowel Disease Center, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Yamauchi
authors.affiliation: Keiichi Mitsuyama, Inflammatory Bowel Disease Center, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Fukunaga
authors.affiliation: Keiichi Mitsuyama, Inflammatory Bowel Disease Center, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Torimura
mesh_terms: D000906:Antibodies / Q000097:blood*; D000907:Antibodies, Bacterial / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003093:Colitis, Ulcerative / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology / Q000628:therapy; D003424:Crohn Disease / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology / Q000628:therapy; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D012698:Serologic Tests
chemical_list: D000906:Antibodies; D000907:Antibodies, Bacterial; D001323:Autoantibodies; D015415:Biomarkers
keywords: Biomarker; Crohn’s disease; Serological antibody; Ulcerative colitis
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