title: Analogs of 1α,25-Dihydroxyvitamin D₃ in Clinical Use.
abstract: Biologically active metabolites of vitamin D that have been successfully developed for the clinical market are described. Their properties that resulted in their success in the clinic are also provided. Precursors of the metabolically active 1α,25-dihydroxyvitamin D have been prepared and successfully marketed not only for renal failure patients but also for a variety of patients having metabolic bone disorders. Finally, successful analogs of 1α,25-dihydroxyvitamin D in use in the clinic worldwide are presented including properties that have contributed to their success.
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA. Electronic address: deluca@biochem.wisc.edu.
authors.forename: Hector F
authors.initials: HF
authors.lastname: DeLuca
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Lori A
authors.initials: LA
authors.lastname: Plum
mesh_terms: D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D014807:Vitamin D; D002117:Calcitriol; D002118:Calcium
keywords: 1,25-Dihydroxyvitamin D analogs; 1,25-Dihydroxyvitamin D precursors; Osteoporosis; Secondary hyperparathyroidism; Vitamin D metabolites