title: Translational opportunities for targeting the Th17 axis in acute graft-vs.-host disease.
abstract: Allogeneic stem cell transplantation (allo-SCT) is a curative therapy for different life-threatening malignant and non-malignant hematologic disorders. Acute graft-vs.-host disease (aGVHD) and particularly gastrointestinal aGVHD remains a major source of morbidity and mortality following allo-SCT, which limits the use of this treatment in a broader spectrum of patients. Better understanding of aGVHD pathophysiology is indispensable to identify new therapeutic targets for aGVHD prevention and therapy. Growing amount of data suggest a role for T helper (Th)17 cells in aGVHD pathophysiology. In this review, we will discuss the current knowledge in this area in animal models and in humans. We will then describe new potential treatments for aGVHD along the Th17 axis.
authors.affiliation: Université Pierre et Marie Curie, Paris, France.|Centre de recherche Saint-Antoine, INSERM, UMRs 938, Paris, France.|Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, APHP, Paris, France.|INSERM, UMR 1064-Center for Research in Transplantation and Immunology, Nantes, F44093 France.
authors.forename: F
authors.initials: F
authors.lastname: Malard
authors.affiliation: Université Pierre et Marie Curie, Paris, France.|Centre de recherche Saint-Antoine, INSERM, UMRs 938, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Gaugler
authors.affiliation: Université Pierre et Marie Curie, Paris, France.|Centre de recherche Saint-Antoine, INSERM, UMRs 938, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Lamarthee
authors.affiliation: Université Pierre et Marie Curie, Paris, France.|Centre de recherche Saint-Antoine, INSERM, UMRs 938, Paris, France.|Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, APHP, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Mohty
mesh_terms: D000208:Acute Disease; D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000276:immunology; D004195:Disease Models, Animal; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D006086:Graft vs Host Disease / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D006402:Hematologic Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D051379:Mice; D058990:Molecular Targeted Therapy; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D058504:Th17 Cells / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D014184:Transplantation, Homologous
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D016207:Cytokines
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