title: New cytotoxic cyclic peroxide acids fromPlakortissp. marine sponge.
abstract: Bioassay-guided fractionation of the extract of Jamaican marine spongePlakortissp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (1a, 2a, 3a, 4, 5), known plakortides (6,7), known bicyclic lactone (8) and new cyclic peroxide acids (1b, 2b, 3b). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.
authors.affiliation: Chemistry Department, Univeristy of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Hoye
authors.affiliation: Marine Chemistry Department, Faculty of Marine Sciences, King Abdulaziz University, P. O. Box 80207, Jeddah 21589, Saudi Arabia.
authors.forename: Walied M
authors.initials: WM
authors.lastname: Alarif
authors.affiliation: Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
authors.forename: Salim S
authors.initials: SS
authors.lastname: Basaif
authors.affiliation: Medicinal Chemistry, Univeristy of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abo-Elkarm
authors.affiliation: Department of Pharmacognosy, School of Pharmacy Mississippi Univeristy, Mississippi 38677, USA.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
authors.affiliation: Department of Pharmacognosy, School of Pharmacy Mississippi Univeristy, Mississippi 38677, USA.
authors.forename: Amir E
authors.initials: AE
authors.lastname: Wahba
authors.affiliation: Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia; Department of Chemistry, Faculty of Science, Damietta University, Damietta, Egypt.
authors.forename: Seif-Eldin N
authors.initials: SN
authors.lastname: Ayyad
keywords: Plakortis sponge; cyclic peroxides; cytotoxicity; polyketides
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