title: Drug carriers based on highly protein-resistant materials for prolonged in vivo circulation time.
abstract: Long-circulating drug carriers are highly desirable in drug delivery system. However, nonspecific protein adsorption leaves a great challenge in drug delivery of intravenous administration and significantly affects both the pharmacokinetic profiles of the carrier and drugs, resulting in negatively affect of therapeutic efficiency. Therefore, it is important to make surface modification of drug carriers by protein-resistant materials to prolong the blood circulation time and increase the targeted accumulation of therapeutic agents. In this review, we highlight the possible mechanism of protein resistance and recent progress of the alternative protein-resistant materials and their drug carriers, such as poly(ethylene glycol), oligo(ethylene glycol), zwitterionic materials, and red blood cells adhesion.
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Science, Beijing 100190, People's Republic of China, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, People's Republic of China and University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
authors.forename: Ruiyuan
authors.initials: R
authors.lastname: Liu
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Science, Beijing 100190, People's Republic of China, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, People's Republic of China and University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Science, Beijing 100190, People's Republic of China, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, People's Republic of China and University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Science, Beijing 100190, People's Republic of China, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, People's Republic of China and University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
keywords: drug carrier; long circulation; nonspecific protein adsorption materials; surface modification
references.citation: J Control Release. 2014 Feb 28;176:104-14
references.pmid: 24365128
references.citation: FEBS Lett. 1990 Jul 30;268(1):235-7
references.pmid: 2384160
references.citation: Adv Drug Deliv Rev. 2013 Jan;65(1):24-35
references.pmid: 22964425
references.citation: Biomaterials. 2010 Jun;31(17):4757-63
references.pmid: 20303164
references.citation: Anal Bioanal Chem. 2005 Feb;381(3):534-46
references.pmid: 15723256
references.citation: Cell Mol Biol Lett. 2002;7(2):286
references.pmid: 12097957
references.citation: J Microencapsul. 1998 Jan-Feb;15(1):1-19
references.pmid: 9463803
references.citation: Biomaterials. 2015 Feb;41:1-14
references.pmid: 25522960
references.citation: Adv Mater. 2010 Mar 5;22(9):920-32
references.pmid: 20217815
references.citation: J Control Release. 2004 Nov 5;100(1):5-28
references.pmid: 15491807
references.citation: Langmuir. 2005 Apr 12;21(8):3591-8
references.pmid: 15807606
references.citation: Langmuir. 2012 Jan 31;28(4):2137-44
references.pmid: 22220597
references.citation: Adv Mater. 2012 Oct 23;24(40):5476-80
references.pmid: 22886872
references.citation: Langmuir. 2006 Feb 28;22(5):2222-6
references.pmid: 16489810
references.citation: Cancer Res. 1994 Feb 15;54(4):987-92
references.pmid: 8313389
references.citation: J Control Release. 2007 Feb 12;117(2):256-66
references.pmid: 17188777
references.citation: Exp Biol Med (Maywood). 2007 Jul;232(7):958-66
references.pmid: 17609513
references.citation: Gene Ther. 2007 Jan;14(1):68-77
references.pmid: 16915290
references.citation: J Biomater Sci Polym Ed. 2014;25(14-15):1502-13
references.pmid: 24953966
references.citation: Cancer Res. 1993 Aug 15;53(16):3765-70
references.pmid: 8339289
references.citation: Theranostics. 2015 Feb 27;5(6):583-96
references.pmid: 25825598
references.citation: J Pharmacol Exp Ther. 2000 Mar;292(3):1071-9
references.pmid: 10688625
references.citation: Pharm Res. 2009 Oct;26(10):2270-9
references.pmid: 19633820
references.citation: Int J Pharm. 2008 Apr 16;354(1-2):56-62
references.pmid: 18083313
references.citation: J Phys Chem B. 2006 Jun 8;110(22):10799-804
references.pmid: 16771329
references.citation: Macromol Biosci. 2005 Apr 19;5(4):314-21
references.pmid: 15818584
references.citation: Biomacromolecules. 2006 Dec;7(12):3311-5
references.pmid: 17154457
references.citation: Langmuir. 2009 Mar 3;25(5):3196-9
references.pmid: 19437722
references.citation: Biomaterials. 2011 Jan;32(2):628-38
references.pmid: 20888634
references.citation: J Control Release. 2004 Nov 5;100(1):111-9
references.pmid: 15491815
references.citation: Adv Drug Deliv Rev. 2006 Dec 1;58(14):1532-55
references.pmid: 17092599
references.citation: Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1620-2
references.pmid: 1934187
references.citation: J Control Release. 2009 Aug 4;137(3):234-40
references.pmid: 19361546
references.citation: Blood Cells Mol Dis. 1997;23(1):58-68
references.pmid: 9215751
references.citation: Prog Lipid Res. 2003 Nov;42(6):463-78
references.pmid: 14559067
references.citation: J Am Chem Soc. 2005 Oct 19;127(41):14473-8
references.pmid: 16218643
references.citation: Bioconjug Chem. 2006 May-Jun;17(3):603-9
references.pmid: 16704197
references.citation: J Control Release. 2005 Oct 20;107(3):502-12
references.pmid: 16154659
references.citation: J Biomater Sci Polym Ed. 2002;13(4):367-90
references.pmid: 12160299
references.citation: ACS Nano. 2012 Oct 23;6(10):8970-82
references.pmid: 23043240
references.citation: J Am Chem Soc. 2009 Dec 2;131(47):17042-3
references.pmid: 19891442
references.citation: Langmuir. 2001 May 1;17(9):2841-2850
references.pmid: 34139796
references.citation: Colloids Surf B Biointerfaces. 2000 Oct 1;18(3-4):261-275
references.pmid: 10915948
references.citation: Chem Rev. 2002 Nov;102(11):4177-89
references.pmid: 12428987
references.citation: Biomaterials. 2009 Oct;30(29):5617-21
references.pmid: 19595457
references.citation: Biomaterials. 2012 Jun;33(19):4928-35
references.pmid: 22469293
references.citation: Angew Chem Int Ed Engl. 2010 May 17;49(22):3771-6
references.pmid: 20397173
references.citation: J Pharm Sci. 2011 Nov;100(11):5069-77
references.pmid: 21721002
references.citation: J Biomed Mater Res A. 2003 May 1;65(2):209-14
references.pmid: 12734814
references.citation: Biomaterials. 2014 Dec;35(36):9731-45
references.pmid: 25189519
references.citation: J Control Release. 2006 Nov 28;116(2):179-91
references.pmid: 16891028