title: Hypocrol A, a new tyrosol derivative from a sponge-derived strain of the fungus Hypocrea koningii.
abstract: In continuation of our search for new antibacterial and antioxidant metabolites from sponge-derived fungi, one new tyrosol derivative, hypocrol A (1), together with four known congeners, trichodenol B (2), 4-hydroxyphenethyl acetate (3), 4-hydroxyphenethyl tetradecanoate (4) and 1-oleyltyrosol (5), was isolated from the strain Hypocrea koningii PF04. Their planar structures were unequivocally elucidated by spectroscopic methods and comparison with the literature data. All the compounds displayed weak antibacterial activities against Staphylococcus aureus, methicillin-resistant S. aureus and Escherichia coli, whereas compounds 1 and 2 exhibited a moderate antioxidant efficacy in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay with IC50 values of 48.5 and 97.4 μg/mL, respectively.
authors.affiliation: a College of Pharmacy , Jinan University , Guangzhou , PR China.|b Department of Chemistry , Jinan University , Guangzhou , PR China.|c State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, School of Medicine, Marine Drugs Research Center, Ren Ji Hospital , Shanghai Jiao Tong University , Shanghai , PR China.
authors.forename: Li-Jian
authors.initials: LJ
authors.lastname: Ding
authors.affiliation: c State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, School of Medicine, Marine Drugs Research Center, Ren Ji Hospital , Shanghai Jiao Tong University , Shanghai , PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.affiliation: d State Key Laboratory of Microbial Metabolism, Marine Biotechnology Laboratory, School of Life Sciences and Biotechnology , Shanghai Jiao Tong University , Shanghai , PR China.
authors.forename: Ying-Xin
authors.initials: YX
authors.lastname: Li
authors.affiliation: b Department of Chemistry , Jinan University , Guangzhou , PR China.
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Liao
authors.affiliation: b Department of Chemistry , Jinan University , Guangzhou , PR China.
authors.forename: Huan
authors.initials: H
authors.lastname: Sun
authors.affiliation: b Department of Chemistry , Jinan University , Guangzhou , PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Peng
authors.affiliation: c State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, School of Medicine, Marine Drugs Research Center, Ren Ji Hospital , Shanghai Jiao Tong University , Shanghai , PR China.
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Han
authors.affiliation: c State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, School of Medicine, Marine Drugs Research Center, Ren Ji Hospital , Shanghai Jiao Tong University , Shanghai , PR China.
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
authors.affiliation: d State Key Laboratory of Microbial Metabolism, Marine Biotechnology Laboratory, School of Life Sciences and Biotechnology , Shanghai Jiao Tong University , Shanghai , PR China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Li
authors.affiliation: c State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, School of Medicine, Marine Drugs Research Center, Ren Ji Hospital , Shanghai Jiao Tong University , Shanghai , PR China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: a College of Pharmacy , Jinan University , Guangzhou , PR China.|b Department of Chemistry , Jinan University , Guangzhou , PR China.
authors.forename: Shi-Hai
authors.initials: SH
authors.lastname: Xu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds; D002851:Chromatography, High Pressure Liquid; D004926:Escherichia coli / Q000187:drug effects; D005285:Fermentation; D035901:Hypocrea / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010851:Picrates; D011161:Porifera / Q000382:microbiology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; C000617288:hypocrol A; C011867:4-hydroxyphenylethanol; C004931:1,1-diphenyl-2-picrylhydrazyl; D010626:Phenylethyl Alcohol
keywords: Hypocrea koningii; antibacterial activity; antioxidant; tyrosol derivative