title: Overview on Peroxiredoxin.
abstract: Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that reduce peroxides, with a conserved cysteine residue, designated the "peroxidatic" Cys (CP) serving as the site of oxidation by peroxides (Hall et al., 2011; Rhee et al., 2012). Peroxides oxidize the CP-SH to cysteine sulfenic acid (CP-SOH), which then reacts with another cysteine residue, named the "resolving" Cys (CR) to form a disulfide that is subsequently reduced by an appropriate electron donor to complete a catalytic cycle. This overview summarizes the status of studies on Prxs and relates the following 10 minireviews.
authors.affiliation: Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea.
authors.forename: Sue Goo
authors.initials: SG
authors.lastname: Rhee
mesh_terms: D000818:Animals; D020134:Catalytic Domain; D017124:Conserved Sequence; D003545:Cysteine / Q000378:metabolism; D006801:Humans; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism; D054464:Peroxiredoxins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D010545:Peroxides; D054464:Peroxiredoxins; D003545:Cysteine
keywords: circadian rhythm; hydrogen peroxide; peroxiredoxin; redox regulation; thiol-specific peroxidasee
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