title: Increased Odds of Melanoma: Parkinson's Disease, Essential Tremor, Dystonia versus Controls.
abstract: OBJECTIVE
  Patients with Parkinson's disease (PD) have an increased risk of melanoma, although the mechanisms are unclear. We are unaware of studies that have assessed the association between other movement disorders, such as essential tremor (ET) and dystonia, and melanoma. In this study, we assessed the association between ET, PD, dystonia and cancer (esp. melanoma).
  
  
  METHODS
  One hundred and eight PD cases, 139 ET cases, and 54 dystonia cases, and 124 controls were enrolled in a research study of the epidemiology of movement disorders (total n = 425). The groups were frequency matched on age and gender. Cancer diagnoses were made based on self-reports. Melanoma diagnoses were further validated.
  
  
  RESULTS
  The prevalence of melanoma was higher in PD cases than controls (13.9 vs. 1.6%, p < 0.001), and was marginally higher in ET cases (5.8%, p = 0.08) and dystonia cases (7.4%, p = 0.06) than controls. In adjusted logistic regression models, the odds of melanoma was 7.09-9.84 times higher in PD cases than controls (p values 0.01-0.003), 3.73-4.10 times higher in ET cases than controls (p values 0.08-0.10), and 4.88-5.27 times higher in dystonia cases than controls (p values 0.06-0.07).
  
  
  CONCLUSIONS
  The links between neurological disorders and melanoma, long-known, may not be specific to PD and may extend to other movement disorders.
authors.affiliation: Department of Neurology, Yale School of Medicine, Yale University, New Haven, Conn., USA.
authors.forename: Sherif Y
authors.initials: SY
authors.lastname: Shalaby
authors.forename: Elan D
authors.initials: ED
authors.lastname: Louis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004421:Dystonia / Q000453:epidemiology*; D020329:Essential Tremor / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology*; D010300:Parkinson Disease / Q000453:epidemiology*; D012307:Risk Factors
references.citation: J Neurol. 2015 Jun;262(6):1579-80
references.pmid: 25929660
references.citation: Sci Rep. 2015 Mar 12;5:9029
references.pmid: 25761573
references.citation: Tremor Other Hyperkinet Mov (N Y). 2015 May 27;5:null
references.pmid: 26056611
references.citation: Parkinsonism Relat Disord. 2012 Mar;18(3):279-84
references.pmid: 22130149
references.citation: Parkinsonism Relat Disord. 2009 Sep;15(8):551-3
references.pmid: 19501540
references.citation: Am J Epidemiol. 2003 Mar 15;157(6):539-45
references.pmid: 12631544
references.citation: Science. 2003 Jan 10;299(5604):256-9
references.pmid: 12446870
references.citation: Arch Dermatol. 2004 Jun;140(6):730-5
references.pmid: 15210466
references.citation: Int J Neurosci. 1990 Aug;53(2-4):241-2
references.pmid: 2176181
references.citation: Neurology. 2011 Jun 7;76(23):2002-9
references.pmid: 21646627
references.citation: Mov Disord. 2008 Sep 15;23(12):1747-51
references.pmid: 18709680
references.citation: Br J Cancer. 2015 Mar 3;112(5):925-33
references.pmid: 25688738
references.citation: J Am Geriatr Soc. 1968 May;16(5):622-6
references.pmid: 5646906
references.citation: Arq Neuropsiquiatr. 2009 Mar;67(1):21-4
references.pmid: 19330204
references.citation: Parkinsonism Relat Disord. 2003 Mar;9(4):239-41
references.pmid: 12618060
references.citation: Ann Neurol. 2015 May;77(5):889-94
references.pmid: 25631192
references.citation: Neurology. 1992 Jun;42(6):1142-6
references.pmid: 1603339
references.citation: Mov Disord. 2010 Apr 15;25(5):534-41
references.pmid: 20175185
references.citation: Am J Epidemiol. 1986 May;123(5):894-900
references.pmid: 3962971
references.citation: Neurology. 2014 Nov 4;83(19):e177
references.pmid: 25367063
references.citation: Neurology. 2014 Apr 22;82(16):1441-8
references.pmid: 24719490
references.citation: Int J Cancer. 2006 Sep 1;119(5):1014-22
references.pmid: 16570276
references.citation: J Alzheimers Dis. 2014;40(2):465-73
references.pmid: 24448786
references.citation: Neurology. 2000 Mar 14;54(5):1195-8
references.pmid: 10720300
references.citation: Neuroepidemiology. 1997;16(3):124-33
references.pmid: 9159767
references.citation: Adv Neurol. 1988;50:1-8
references.pmid: 3041755
references.citation: Am J Epidemiol. 1994 Feb 15;139(4):408-14
references.pmid: 8109575
references.citation: Diabetes Care. 2010 Jul;33(7):1674-85
references.pmid: 20587728
references.citation: J Neurol Neurosurg Psychiatry. 2009 Apr;80(4):423-5
references.pmid: 19289477