title: Weak two-photon absorption applied to the rapid prototyping of cell scaffolds.
abstract: Two-photon polymerization (TPP) has been employed to generate deep structures using the biocompatible and optically transparent monomer ethoxylated bisphenol A dimethacrylate (EO=6) (EBPADMA) and 4, 4'-Bis(diethylamino)benzophenon as the photoinitiator. The two-photon absorption cross section of the initiator was measured to be 1 GM (1  GM=1×10(-50)  cm(4) s photon(-1)) in EBPADMA. Here we have explored a weak absorption regime whereby deep structures (∼300  μm) can be generated in a single pass. This allows rapid fabrication of structures suitable for cell scaffolds where the length scales are small, ∼10  μm, but are required over long ranges, ∼cm. The dependence of the TPP properties on the writing power, speed, exposure time and NA, of the focusing lens were studied in detail. Diffraction calculations for the focusing optics employed show that spherical aberration plays a significant role in determining the feature sizes achieved.
authors.forename: Bibi Safia
authors.initials: BS
authors.lastname: Haq
authors.forename: Hidayat Ullah
authors.initials: HU
authors.lastname: Khan
authors.forename: Khan
authors.initials: K
authors.lastname: Alam
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Attaullah
authors.forename: Mamoona
authors.initials: M
authors.lastname: Sultan
mesh_terms: D065638:Absorption, Radiation; D001559:Benzhydryl Compounds / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D017785:Photons; D058105:Polymerization; D016062:Porosity; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D008689:Methacrylates; C002462:4,4'-isopropylidenediphenol dimethacrylate; D000098826:Bisphenol A Compounds