title: Neuroprotective effect of lignans extracted from Eucommia ulmoides Oliv. on glaucoma-related neurodegeneration.
abstract: Glaucoma is a progressive neurodegenerative disease, characterized by retinal ganglion cells (RGCs) and axon degeneration. The development of neuroprotective drug is required for improving the efficiency of glaucoma treatment. Eucommia ulmoides Oliv. has been used as a source of traditional medicine and as a beneficial health food. Lignans is one of the main bioactive components of Eucommia ulmoides. Here, we show that lignans protects RGCs against oxidative stress-induced injury in vitro. Moreover, lignans exerts neuroprotective effect on glaucoma-associated optic neuropathy in glaucomatous rats. Lignans treatment could improve oxidative stress response in RGCs and retinas of glaucomatous rats. Lignans plays an anti-oxidative stress role via the activation of AMPK signaling. This study provides evidence that lignans possesses protective effect on glaucoma-associated optic neuropathy. Lignans might be an alternative for the prevention and treatment of glaucomatous neurodegeneration.
authors.affiliation: Department of Ophthalmology, Eye Institute of Xuzhou, Xuzhou, 221000, Jiangsu, China. chaopengli1981@126.com.
authors.forename: Chao-Peng
authors.initials: CP
authors.lastname: Li
authors.affiliation: Department of Health, Linyi People's Hospital, Shandong University, Linyi, 276003, Shandong, China.
authors.forename: Gui-Zhen
authors.initials: GZ
authors.lastname: Qiu
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.|Department of Cardiology, Shanghai Tenth People's Hospital Chongming Branch, Shanghai, 202157, China.
authors.forename: Ban
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, Linyi People's Hospital, Shandong University, Linyi, 276003, Shandong, China.
authors.forename: Jin-Long
authors.initials: JL
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Linyi People's Hospital, Shandong University, Linyi, 276003, Shandong, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Fu
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D031283:Eucommiaceae / Q000737:chemistry*; D005452:Fluoresceins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D005901:Glaucoma / Q000150:complications* / Q000188:drug therapy; D006861:Hydrogen Peroxide / Q000494:pharmacology; D017705:Lignans / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D009901:Optic Nerve Diseases / Q000188:drug therapy* / Q000209:etiology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012165:Retinal Ganglion Cells / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D012844:Sincalide / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism
chemical_list: D005452:Fluoresceins; D017705:Lignans; D018696:Neuroprotective Agents; D062085:RNA, Long Noncoding; C498585:TUBB3 protein, human; C000598536:TUG1 long noncoding RNA, human; D014404:Tubulin; C085925:calcein AM; D006861:Hydrogen Peroxide; D010751:Phosphopyruvate Hydratase; D012844:Sincalide
keywords: AMPK signaling; Glaucoma; Lignans; Retinal ganglion cells
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