title: Hydrogen-Transfer-Mediated Direct β-Alkylation of Aryl-1,8-naphthyridines with Alcohols under Transition Metal Catalyst Free Conditions.
abstract: By employing abundant and sustainable alcohols as the alkylating reagents, a new and direct alkylation method has been demonstrated. This method enables the selective alkylation of the less substituted pyridyl ring at the β-site of aryl-1,8-naphthyridines, affording the desired products in moderate to excellent yields upon isolation. The method proceeds under transition-metal-free conditions in an atom- and step-economic fashion and liberates water as the sole byproduct. Mechanistic investigations suggest the reaction undergoes a hydrogen-transfer-mediated alkylation mode.
authors.affiliation: School of Chemistry & Chemical Engineering, South China University of Technology , Wushan Rd-381, Guangzhou 510641, People's Republic of China.
authors.forename: Biao
authors.initials: B
authors.lastname: Xiong
authors.affiliation: School of Chemistry & Chemical Engineering, South China University of Technology , Wushan Rd-381, Guangzhou 510641, People's Republic of China.
authors.forename: Shudi
authors.initials: S
authors.lastname: Zhang
authors.affiliation: School of Chemistry & Chemical Engineering, South China University of Technology , Wushan Rd-381, Guangzhou 510641, People's Republic of China.
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.affiliation: School of Chemistry & Chemical Engineering, South China University of Technology , Wushan Rd-381, Guangzhou 510641, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang