title: The influence of topography on tissue engineering perspective.
abstract: The actual in vivo tissue scaffold offers a three-dimensional (3D) structural support along with a nano-textured surfaces consist of a fibrous network in order to deliver cell adhesion and signaling. A scaffold is required, until the tissue is entirely regenerated or restored, to act as a temporary ingrowth template for cell proliferation and extracellular matrix (ECM) deposition. This review depicts some of the most significant three dimensional structure materials used as scaffolds in various tissue engineering application fields currently being employed to mimic in vivo features. Accordingly, some of the researchers' attempts have envisioned utilizing graphene for the fabrication of porous and flexible 3D scaffolds. The main focus of this paper is to evaluate the topographical and topological optimization of scaffolds for tissue engineering applications in order to improve scaffolds' mechanical performances.
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Negar
authors.initials: N
authors.lastname: Mansouri
authors.affiliation: Nanotechnology & Catalysis Research Centre (NANOCAT), IPS Building, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: samira_bagheri@edu.um.my.
authors.lastname: SamiraBagheri
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D006108:Graphite / Q000737:chemistry; D006801:Humans; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D006108:Graphite
keywords: Carbon nanomaterials; Graphene; Nanoscale features; Nanotechnology; Scaffolds