title: Recurrent Stroke with Rapid Development of Intracranial Stenoses in Polycythemia Vera.
abstract: Polycythemia vera (PV) is a blood disorder in which the first expression may be an ischemic stroke. Stroke mechanism in PV is usually attributed to a hypercoagulability state and blood stasis. We report a case of a patient with PV presenting with recurrent ischemic stroke associated with the development of large intracranial stenosis in a period of 1 month. Stenosis was associated with microembolic signals detected by transcranial Doppler. One year later and after hematocrit control, stenosis persisted but microembolic signals disappeared. We discuss similar reports in the literature and the possible pathophysiological mechanism of large-vessel damage in these patients.
authors.affiliation: Department of Neuroscience, Stroke Unit, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain.
authors.forename: Ane M
authors.initials: AM
authors.lastname: Crespo
authors.affiliation: Department of Neuroscience, Stroke Unit, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Abraira
authors.affiliation: Department of Neuroscience, Stroke Unit, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain.
authors.forename: Nicolau
authors.initials: N
authors.lastname: Guanyabens
authors.affiliation: Department of Neuroscience, Stroke Unit, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: Millán
authors.affiliation: MRI Unit Badalona, Institut de Diagnòstic per la Imatge (IDI), Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Munuera
authors.affiliation: Department of Neuroscience, Stroke Unit, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Dávalos
authors.affiliation: Department of Neuroscience, Stroke Unit, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain. Electronic address: elenacancio@gmail.com.
authors.forename: Elena
authors.initials: E
authors.lastname: López-Cancio
mesh_terms: D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications* / Q000000981:diagnostic imaging; D020521:Stroke / Q000000981:diagnostic imaging / Q000209:etiology*
keywords: Stroke; intracranial stenosis; microembolic signals; polycythemia vera