title: Protective effect of diallylsulphide against mercuric chloride-induced hepatic injury in rats.
abstract: The present study was undertaken to evaluate the effect of diallylsulphide (DAS) against mercuric chloride (HgCl2)-induced oxidative stress in rat livers. Rats were randomly divided into four groups of six rats each and exposed to HgCl2(50 mg/kg/body weight (b.w.)) intraperitoneally and/or DAS (200 mg/kg/b.w.) by gavage. HgCl2administration enhanced alanine aminotransferase (AST) and aspartate aminotransferase (ALT) levels (p < 0.05) with reduction in the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). However, treatment with DAS markedly attenuated HgCl2-induced biochemical alterations in liver and serum transaminases (AST and ALT; p < 0.05). Further, biochemical results were confirmed by histopathological changes as compared to HgCl2-intoxicated rats. Histopathology of liver also showed that administration of DAS significantly reduced the damage generated by HgCl2The present study suggests that DAS shows antioxidant activity and plays a protective role against mercury-induced oxidative damage in the rat livers.
authors.affiliation: Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia sansar@ksu.edu.sa.
authors.forename: S
authors.initials: S
authors.lastname: Ansar
authors.affiliation: Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu Sabah, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Iqbal
mesh_terms: D000498:Allyl Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004785:Environmental Pollutants / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008627:Mercuric Chloride / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D017208:Rats, Wistar; D013440:Sulfides / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000498:Allyl Compounds; D000975:Antioxidants; D015415:Biomarkers; D004785:Environmental Pollutants; D013440:Sulfides; D008627:Mercuric Chloride; C038491:allyl sulfide
keywords: Mercury; antioxidant enzymes; diallylsulphide; liver damage