title: Budd-Chiari Syndrome in Young Chinese: Clinical Characteristics, Etiology and Outcome of Recanalization from a Single Center.
abstract: OBJECTIVE
  We aimed to characterize the clinical profile, etiology, and outcomes of young Chinese patients with Budd-Chiari syndrome treated with recanalization.
  
  
  METHODS
  A total of 35 consecutive young patients (≤25 years of age) with primary Budd-Chiari syndrome treated with recanalization at our center were enrolled in this study between March 2011 and December 2014. Data on baseline information, etiology tests, therapeutic recanalization strategies, and follow-up were collected.
  
  
  RESULTS
  The most common clinical feature was ascites, present in 33 cases (94%). Hepatic vein obstruction was present in 60% (21/35) of patients, inferior vena cava obstruction in 3% (1/35), and combined obstruction in 37% (13/35). The most common risk factor for thrombosis was hyperhomocysteinemia (14/35, 40%). Recanalization was technically successful in 32 of 35 patients (91%), and clinically successful in 28 of these 32 patients (88%). The cumulative 1- and 3-year primary patency rates were 75.2 and 54.3%, respectively. The cumulative 1- and 3-year secondary patency rates were 89.3 and 89.3%, respectively. The cumulative 1- and 3-year survival rates were 96.9 and 93.8%, respectively.
  
  
  CONCLUSIONS
  In this study, the most common type of lesion was hepatic vein obstruction, the most common thrombotic risk factor was hyperhomocysteinemia, and recanalization resulted in good mid-term outcomes in young Chinese patients with Budd-Chiari syndrome.
authors.affiliation: Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, 99 West Huai-hai Road, Xuzhou, 221002, Jiangsu, China. 776260859@qq.com.
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Zhou
authors.affiliation: Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, 99 West Huai-hai Road, Xuzhou, 221002, Jiangsu, China. cuiyanfeng366@126.com.
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Cui
authors.affiliation: Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, 99 West Huai-hai Road, Xuzhou, 221002, Jiangsu, China. cjr.zumaoheng@vip.163.com.
authors.forename: Mao-Heng
authors.initials: MH
authors.lastname: Zu
authors.affiliation: Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, 99 West Huai-hai Road, Xuzhou, 221002, Jiangsu, China. 1427286069@qq.com.
authors.forename: Qing-Qiao
authors.initials: QQ
authors.lastname: Zhang
authors.affiliation: Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, 99 West Huai-hai Road, Xuzhou, 221002, Jiangsu, China. xuhao585@yeah.net.
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D017130:Angioplasty; D006502:Budd-Chiari Syndrome / Q000628:therapy*; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D019919:Prosthesis Implantation; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Budd–Chiari syndrome; Clinical features; Etiology; Recanalization; Young adults