title: GSE1 negative regulation by miR-489-5p promotes breast cancer cell proliferation and invasion.
abstract: Gse1 coiled-coil protein (GSE1), also known as KIAA0182, is a proline rich protein. However, the function of GSE1 is largely unknown. In this study, we reported that GSE1 is overexpression in breast cancer and silencing of GSE1 significantly suppressed breast cancer cells proliferation, migration and invasion. Furthermore, GSE1 was identified as a direct target of miR-489-5p, which is significantly reduced in breast cancer tissues. In addition, forced expression of miR-489-5p suppressed breast cancer cells proliferation, migration and invasion. Moreover, depletion of GSE1 by siRNAs significantly abrogated the enhanced proliferation, migration and invasion of breast cancer cells consequent to miR-489-5p depletion. Taken together, these findings suggest that GSE1 may function as a novel oncogene in breast cancer and it can be regulated by miR-489-5p.
authors.affiliation: Department of General Surgery, The People's Hospital of Bozhou, Bozhou 236800, PR China. Electronic address: chaiyisheng0508@sina.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Chai
authors.affiliation: Department of General Surgery, The People's Hospital of Bozhou, Bozhou 236800, PR China.
authors.forename: Jingzhong
authors.initials: J
authors.lastname: Tian
authors.affiliation: Dept of General Surgery, The Hospital of Suzhou, Suzhou 234000, PR China.
authors.forename: Deyin
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, The People's Hospital of Bozhou, Bozhou 236800, PR China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, The People's Hospital of Bozhou, Bozhou 236800, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Pathology, Anhui Medical University, Hefei 230022, PR China.
authors.forename: Keshuo
authors.initials: K
authors.lastname: Ding
authors.affiliation: Dept of Vascular Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei 230022, PR China. Electronic address: 13399519008@163.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C000608948:GSE1 protein, human; C552418:MIRN489 microRNA, human; D035683:MicroRNAs; D009363:Neoplasm Proteins
keywords: Breast cancer; GSE1; Invasion; Migration; Proliferation; miRNA