title: Anti-Inflammatory Effect of Taurine in Burned Patients.
abstract: OBJECTIVE
  Burn induced inflammatory response can be mediated by reactive oxygen metabolites and accompanied by multiple organ dysfunction. Taurine has protective effects against various inflammatory conditions. The aim of this study was to determine the effect of Taurine supplement in thermal burn victims.
  
  
  METHODS
  Thirty patients with severe thermal burns were enrolled in this randomized double-blinded clinical trial. These patients were randomly divided into two equal groups (namely Control and Taurine groups), where both received isocaloric and isonitrogenous formula. One group was supplemented with 50 mg/kg of Taurine per day for a duration of 10 days. Blood samples were obtained to measure Interleukin-10 (IL-10), high-sensitivity C-reactive protein (hs-CRP), and Tumor Necrosis Factor alpha (TNF-α) levels at the beginning and the end of the study.
  
  
  RESULTS
  Change in serum level of IL-10 in Taurine group was more than Control group [-13.60(-31.40, -10.40) compared to -4.00(-20.00, -0.20) respectively; P = 0.030]. This change was significant in patients with more than 30% TBSA of burn [-14.20(-31.40, -10.40) compared to -2.40(-9.60, 0.40) respectively; P = 0.013]. As for the hs-CRP and TNF-α levels, the difference between the two groups were not significant.
  
  
  CONCLUSIONS
  Based on the results obtained, Taurine supplement showed a positive outcome on anti-inflammatory cytokine IL-10 in all burn patients. This effect was even more significant in patients with higher percentage of burn area. Taurine had no significant effect on the inflammatory marker hs-CRP and the pro-inflammatory cytokine TNF-α level. For a more thorough verification, measurement of a wider range of inflammatory cytokines in more frequent time intervals are suggested.
authors.affiliation: Infectious and Tropical Disease Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sima
authors.initials: S
authors.lastname: Lak
authors.affiliation: Nutrition Research Center, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Ostadrahimi
authors.affiliation: Infectious and Tropical Disease Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Behrooz
authors.initials: B
authors.lastname: Nagili
authors.affiliation: Road Traffic Injury Prevention Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Asghari-Jafarabadi
authors.affiliation: Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sanaz
authors.initials: S
authors.lastname: Beigzali
authors.affiliation: Burn Center, Sina Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Feridoon
authors.initials: F
authors.lastname: Salehi
authors.affiliation: Scientific Associate, Global eLearning Academy, Geneva, Switzerland.
authors.forename: Roxana
authors.initials: R
authors.lastname: Djafarzadeh
keywords: Burns; Nutrition; Systematic Inflammatory Response Syndrome; Taurine
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