title: Honeycomb-shaped surface topography induces differentiation of human mesenchymal stem cells (hMSCs): uniform porous polymer scaffolds prepared by the breath figure technique.
abstract: Polystyrene honeycomb scaffolds with different pore sizes were successfully fabricated by casting a polymer solution under humid conditions in order to investigate the effect of porous microtopography on hMSC differentiation. We have used honeycomb scaffolds to achieve the microtopography-induced differentiation of hMSCs. Honeycomb scaffolds led hMSCs to osteospecific and myospecific differentiations depending on the size of pores. This selective differentiation suggested that surface microtopography alone may be effective for using hMSCs in regenerative medicine and tissue engineering.
authors.affiliation: WPI-Advanced Institute for Materials Research, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai, 980-8577, Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Kawano
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai, 980-8577, Japan. yabu@tagen.tohoku.ac.jp.
authors.forename: Madoka
authors.initials: M
authors.lastname: Sato
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai, 980-8577, Japan. yabu@tagen.tohoku.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yabu
authors.affiliation: WPI-Advanced Institute for Materials Research, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai, 980-8577, Japan and Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai, 980-8577, Japan. yabu@tagen.tohoku.ac.jp and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8, Kawaguchi, Saitama, 332-0012, Japan.
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Shimomura