title: Bioimpedence to Assess Breast Density as a Risk Factor for Breast Cancer in Adult Women and Adolescent Girls.
abstract: Although high mammographic density is one of the strongest predictors of breast cancer risk, X-ray based mammography cannot be performed before the recommended screening age, especially not in adolescents and young women. Therefore, new techniques for breast density measurement are of interest. In this pilot study in Guam and Hawaii, we evaluated a radiation-free, bioimpedance device called Electrical Breast DensitometerTM (EBD; senoSENSE Medical Systems, Inc., Ontario, Canada) for measuring breast density in 95 women aged 31-82 years and 41 girls aged 8-18 years. Percent density (PD) was estimated in the women's most recent mammogram using a computer-assisted method. Correlation coefficients and linear regression were applied for statistical analysis. In adult women, mean EBD and PD values of the left and right breasts were 230±52 and 226±50 Ω and 23.7±15.1 and 24.2±15.2%, respectively. The EBD measurements were inversely correlated with PD (rSpearman=-0.52, p<0.0001); the correlation was stronger in Caucasians (rSpearman=-0.70, p<0.0001) than Asians (rSpearman=-0.54, p<0.01) and Native Hawaiian/Chamorro/Pacific Islanders (rSpearman=-0.34, p=0.06). Using 4 categories of PD (<10, 10-25, 26-50, 51-75%), the respective mean EBD values were 256±32, 249±41, 202±46, and 178±43 Ω (p<0.0001). In girls, the mean EBD values in the left and right breast were 148±40 and 155±54 Ω; EBD values decreased from Tanner stages 1 to 4 (204±14, 154±79, 136±43, and 119±16 Ω for stages 1-4, respectively) but were higher at Tanner stage 5 (165±30 Ω). With further development, this bioimpedance method may allow for investigations of breast development among adolescent, as well as assessment of breast cancer risk early in life and in populations without access to mammography.
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA E-mail : gertraud@cc.hawaii.edu.
authors.forename: Gertraud
authors.initials: G
authors.lastname: Maskarinec
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Michelle B
authors.initials: MB
authors.lastname: Laguana
authors.forename: Rachel
authors.initials: R
authors.lastname: Novotny
authors.forename: Rachael T
authors.initials: RT
authors.lastname: Leon Guerrero
mesh_terms: D000293:Adolescent; D001940:Breast / Q000473:pathology*; D000071060:Breast Density / Q000473:pathology*; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology*; D002170:Canada; D002648:Child; D005260:Female; D006801:Humans; D016014:Linear Models; D008327:Mammography / Q000379:methods; D008875:Middle Aged; D010865:Pilot Projects; D012307:Risk Factors
references.citation: Biometrics. 1999 Dec;55(4):1137-44
references.pmid: 11315059
references.citation: Hawaii Med J. 2002 Mar;61(3):53
references.pmid: 11965840
references.citation: N Engl J Med. 2004 Oct 14;351(16):1679-81
references.pmid: 15483288
references.citation: Br J Cancer. 1998 Nov;78(9):1233-8
references.pmid: 9820186
references.citation: Radiographics. 1998 Nov-Dec;18(6):1587-98
references.pmid: 9821201
references.citation: Lancet Oncol. 2005 Oct;6(10):798-808
references.pmid: 16198986
references.citation: Breast Cancer Res Treat. 2005 Nov;94(2):115-22
references.pmid: 16261410
references.citation: Med Phys. 2007 Feb;34(2):744-53
references.pmid: 17388192
references.citation: Ann Intern Med. 2008 Mar 4;148(5):337-47
references.pmid: 18316752
references.citation: Breast Cancer Res. 2008;10(3):209
references.pmid: 18598375
references.citation: Med Phys. 2008 Sep;35(9):3988-97
references.pmid: 18841850
references.citation: Lancet Oncol. 2009 Jun;10(6):569-80
references.pmid: 19409844
references.citation: Curr Opin Clin Nutr Metab Care. 2009 Sep;12(5):482-6
references.pmid: 19494768
references.citation: Maturitas. 2009 Sep 20;64(1):20-6
references.pmid: 19709825
references.citation: Ann Intern Med. 2009 Nov 17;151(10):716-26, W-236
references.pmid: 19920272
references.citation: Cancer Epidemiol. 2011 Apr;35(2):188-93
references.pmid: 20688593
references.citation: Am J Hum Biol. 2011 May-Jun;23(3):359-65
references.pmid: 21445936
references.citation: BMC Cancer. 2011;11:330
references.pmid: 21810248
references.citation: Hawaii J Med Public Health. 2014 Oct;73(10):335-40
references.pmid: 25337453