title: Atypical Phenotypes in Classical Hodgkin Lymphoma.
abstract: Classical Hodgkin lymphoma has a characteristic immunophenotype in most cases, with expression of CD30, CD15, and PAX-5, and absence of CD45 and T-lineage markers. However, in a significant subset of cases, atypical staining patterns may be seen for one or more antigens, particularly negative staining for CD15 or staining for one or more B-lineage markers, such as CD20, CD79a, OCT-2, or BOB.1. The greatest pitfall is in the misinterpretation of other cells, such as immunoblasts or histiocytes, as Hodgkin cells.
authors.affiliation: Clarient Diagnostic Services, Inc, 31 Columbia, Aliso Viejo, CA 92656, USA. Electronic address: lweiss@clarientinc.com.
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Weiss
keywords: BOB.1; CD15; CD20; CD30; CD45; CD79a; Immunohistochemistry; OCT-2; PAX-5