title: Effects of spironolactone towards rabbit atrial remodeling with rapid pacing.
abstract: This study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing (RAP). 30 rabbits were randomly divided into control group, RAP group and spironolactone group, with 10 rabbits in each group. RAP was performed at the speed of 800 beats/min for 8 h, atrial effective refractory period (AERP) was determined before and at the 1(st), 2(nd), 4(th), 6(th) and 8(th) of the pacing, the expressions of atrial muscular calcium channel α1C subunit and β1 subunit mRNA were performed the RT-PCR detection, and ultrastructural changes of atrial myocytes were observed. AERP of RAP group shortened, with poor frequency adaptability; the expressions of calcium channel α1C subunit and β1 subunit mRNA decreased 22% and 26%, respectively, when compared with the control group; ultrastructure of atrial myocytes changed significantly. AERP of spironotlactone group shortened less that RAP group, and the frequency adaptability was maintained, the decreased expressions of calcium channel α1C subunit and β1 subunit mRNA significantly reduced. RAP could cause atrial remodeling, while spironolactone could inhibit RAP-induced atrial remodeling.
authors.affiliation: Department of Cardiology, People's Liberation Army No. 105 Hospital, Hefei, Anhui Province, PR China.
authors.forename: Lian-Fa
authors.initials: LF
authors.lastname: Wang
authors.affiliation: Deptt. of Cardiology, Dongying Hospital of Shangdong Province-owned Hospital Group, Dongying, Shandong Province, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Gu
authors.affiliation: Deptt. of Cardiology, Dongying Hospital of Shangdong Province-owned Hospital Group, Dongying, Shandong Province, PR China.
authors.forename: Meng-Xun
authors.initials: MX
authors.lastname: Huang
authors.affiliation: Department of Cardiology, People's Liberation Army No. 105 Hospital, Hefei, Anhui Province, PR China.
authors.forename: Wen-Bing
authors.initials: WB
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, People's Liberation Army No. 105 Hospital, Hefei, Anhui Province, PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Cardiology, People's Liberation Army No. 105 Hospital, Hefei, Anhui Province, PR China.
authors.forename: Bang-Zhu
authors.initials: BZ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D064752:Atrial Remodeling / Q000187:drug effects*; D020746:Calcium Channels, L-Type / Q000235:genetics; D002304:Cardiac Pacing, Artificial; D005260:Female; D008297:Male; D011817:Rabbits; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000502:physiology; D013148:Spironolactone / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D020746:Calcium Channels, L-Type; D013148:Spironolactone