title: Meta-analysis of diagnostic value of serum Carbohydrate antigen 199 in pancreatic cancer.
abstract: BACKGROUND
  Carbohydrate antigen 199 (CA199) has been used as a new promising serum biomarker for the diagnosis of pancreatic cancer. But its utility was full of controversies. This study sought to determine the diagnosis value of serum CA199 in pancreatic cancer through enrolling all the related eligible studies.
  
  
  METHODS
  We searched PubMed, Medline, Embase, ISI databases to collect articles in English that evaluated the diagnostic value of CA199 in patients with pancreatic cancer. Two reviewers independently assessed the methodological quality of each study using the quality assessment of diagnostic accuracy studies tool. The data were analyzed using Meta-Disc (Version 1.4) and Stata (Version 12.0) software. We estimated the sensitivity, speciﬁcity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and summary receiver operating characteristic (SROC). A total of 11 studies involving 2,316 individuals were included.
  
  
  RESULTS
  The pooled sensitivity and specificity for CA199 in diagnosing pancreatic cancer were 0.80 (95% confidence interval [CI], 0.77-0.82) and 0.80 (95% CI: 0.77-0.82), respectively. The DOR was 14.79 (95% CI: 8.55-25.59) and the area under the SROC curve was 0.87.
  
  
  CONCLUSIONS
  The current analyses indicated that CA199 is a valuable marker in the diagnosis of pancreatic cancer.
authors.affiliation: Department of Oncology, Linyi Peopales' Hospital, Linyi, China - linsong_lyrm@126.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lihua
authors.initials: L
authors.lastname: Jiang
authors.forename: Lin
authors.initials: L
authors.lastname: Song
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood*; D019317:Evidence-Based Medicine; D006801:Humans; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C578959:carbohydrate antigen 199, human