title: Spanning the genomics era: the vital role of a single institution biorepository for childhood cancer research over a decade.
abstract: The 'genomics era' is considered to have begun with the commencement of the Human Genome Project. As translational genomic studies can only be established when human tissue samples are available for analysis, biospecimens are now proven to be an essential element for their success. During the genomics era the necessity for more extensive biobanking infrastructure has been highlighted. With the increased number of genomic studies into cancer, it is considered that the availability of biospecimens will become the rate limiting step. Despite the efforts in international biobanking, translational genomics is hampered when there low numbers of biospecimens for a particular rare diseases and is most apparent for paediatric cancer. As there is a call for biobanking practice to be responsive to the current experimental needs of the time and for more expansive systems of tissue procurement to be established we have asked the question what role does a single institution biorepository play in the current highly networked world of translational genomics. Here we describe such a case. The Tumour Bank at The Children's Hospital at Westmead (TB-CHW) in the western suburbs of Sydney was formally established in 1998 as a key resource for translational paediatric cancer research. During the genomics era, we show that the TB-CHW has developed into a key biospecimen repository for the cancer research community, during which time it has increasingly found itself having a vital role in the establishment of translational genomics for paediatric cancer. Here we detail metrics that demonstrate how as a single institution biorepository, the TB-CHW has been a strong participant in the advancement of translational genomics throughout the genomics era. This paper describes the significant contribution of a single institutional hospital embedded tumour biobank to the genomic research community. Despite the increased stringencies placed on biobanking practice, the TB-CHW has shown that a single institution biorespository can have a consistent and effective contribution to translational research into rare paediatric malignancy demonstrating its long term benefit throughout the genomics era.
authors.affiliation: The Tumour Bank, Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Westmead, NSW, Australia.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: The Tumour Bank, Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Westmead, NSW, Australia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Catchpoole
keywords: Biobanking; biorepository; childhood cancer; genomics; rare disease; research contribution
references.citation: Cancer Genet. 2014 Sep;207 (9):425-8
references.pmid: 25085602
references.citation: Leuk Res. 2007 Dec;31(12 ):1741-7
references.pmid: 17572488
references.citation: J Clin Invest. 2009 Nov;119(11):3395-407
references.pmid: 19809159
references.citation: Croat Med J. 2013 Oct 28;54(5):501-3
references.pmid: 24170730
references.citation: J Clin Pathol. 2008 Jan;61(1):95-102
references.pmid: 17369505
references.citation: Cancer Res. 2013 Sep 15;73(18):5834-44
references.pmid: 23887970
references.citation: J Pathol. 2007 Jan;211(1):52-9
references.pmid: 17103382
references.citation: Lancet Oncol. 2012 Aug;13(8):838-48
references.pmid: 22691720
references.citation: Nucleic Acids Res. 2013 Jan;41(2):e34
references.pmid: 22923525
references.citation: Nat Rev Genet. 2004 Nov;5(11):866-73
references.pmid: 15520796
references.citation: Endocr Relat Cancer. 2008 Sep;15(3):777-86
references.pmid: 18499731
references.citation: Cancer Res. 2006 Dec 1;66(23):11148-55
references.pmid: 17145858
references.citation: Acta Neuropathol Commun. 2013 Oct 10;1:66
references.pmid: 24252460
references.citation: Epigenetics. 2009 Apr 1;4(3):185-93
references.pmid: 19430199
references.citation: Eur J Hum Genet. 2012 Nov;20(11):1105-11
references.pmid: 22713808
references.citation: Clin Cancer Res. 2011 Feb 1;17(3):505-13
references.pmid: 21177409
references.citation: Cytogenet Genome Res. 2004;106(1):49-54
references.pmid: 15218241
references.citation: BMC Genomics. 2004 Sep 23;5:71
references.pmid: 15387886
references.citation: J Clin Neurosci. 2011 Jan;18(1):122-7
references.pmid: 20965731
references.citation: Cancer Res. 2007 Jan 1;67(1):32-40
references.pmid: 17210681
references.citation: Leuk Res. 2006 Nov;30(11):1355-63
references.pmid: 16620967
references.citation: Oncogene. 2005 Feb 24;24(9):1533-41
references.pmid: 15592497
references.citation: Andrology. 2013 May;1(3):517-29
references.pmid: 23495012
references.citation: J Pediatr. 2013 Jul;163(1):224-9
references.pmid: 23403252
references.citation: Cancer Discov. 2014 Feb;4(2):216-31
references.pmid: 24436047
references.citation: Cancer Res. 2004 Oct 1;64(19):6883-91
references.pmid: 15466177
references.citation: Clin Cancer Res. 2006 Dec 15;12 (24):7284-93
references.pmid: 17189400
references.citation: Diagn Mol Pathol. 2012 Jun;21(2):61-8
references.pmid: 22555088
references.citation: Clin Biochem. 2012 Apr;45(6):379-81
references.pmid: 22424082
references.citation: BMC Med Genomics. 2011 Apr 18;4:35
references.pmid: 21501490
references.citation: Endocr Relat Cancer. 2005 Mar;12 (1):161-72
references.pmid: 15788647
references.citation: Biopreserv Biobank. 2014 Dec;12(6):415-22
references.pmid: 25496154
references.citation: Epigenetics. 2011 Mar;6(3):326-32
references.pmid: 21173572
references.citation: Hematology. 2013 Nov;18(6):315-22
references.pmid: 23433465
references.citation: Carcinogenesis. 2004 Sep;25(9):1599-609
references.pmid: 15090470
references.citation: Clin Cancer Res. 2005 Jan 1;11(1):217-25
references.pmid: 15671549
references.citation: Nat Rev Clin Oncol. 2013 Aug;10(8):437-50
references.pmid: 23799370
references.citation: Mol Cancer. 2010 Feb 25;9:44
references.pmid: 20184741
references.citation: J Clin Oncol. 2010 Dec 1;28(34):e723-4; author reply e725
references.pmid: 21041706
references.citation: Cancer Res. 2006 Apr 1;66(7):3673-80
references.pmid: 16585193
references.citation: Br J Cancer. 2005 Apr 25;92(8):1574-80
references.pmid: 15798773
references.citation: Epigenetics. 2009 May 16;4(4):265-9
references.pmid: 19550140
references.citation: PLoS One. 2013 Oct 11;8(10):e76455
references.pmid: 24146872
references.citation: PLoS Genet. 2014 Jul 10;10(7):e1004475
references.pmid: 25010205
references.citation: Neuro Oncol. 2015 Apr;17(4):526-35
references.pmid: 25246426
references.citation: Biopreserv Biobank. 2012 Dec;10(6):518-25
references.pmid: 24845138
references.citation: Nat Genet. 2012 May 29;44(6):619-22
references.pmid: 22641210
references.citation: J Clin Oncol. 2005 Oct 10;23(29):7322-31
references.pmid: 16145061
references.citation: Gigascience. 2013 May 01;2(1):7
references.pmid: 23634721
references.citation: Leukemia. 2012 May;26(5):918-26
references.pmid: 22116550
references.citation: Biopreserv Biobank. 2014 Jun;12 (3):184-91
references.pmid: 24785371
references.citation: BMC Genomics. 2004 Sep 20;5:70
references.pmid: 15380028
references.citation: Annu Rev Genomics Hum Genet. 2014;15:395-415
references.pmid: 25184532
references.citation: Pediatr Blood Cancer. 2011 Dec 1;57(6):950-7
references.pmid: 21387540
references.citation: Cancer Epidemiol. 2012 Oct;36(5):476-80
references.pmid: 22739323
references.citation: Cancer Epidemiol Biomarkers Prev. 2012 Feb;21(2):253-5
references.pmid: 22313938
references.citation: Nat Med. 2010 Oct;16(10 ):1134-40
references.pmid: 20871609
references.citation: Br J Cancer. 2013 May 28;108(10):2130-41
references.pmid: 23591193
references.citation: PLoS One. 2012;7(4):e35553
references.pmid: 22536405
references.citation: Hum Genet. 2011 Sep;130(3):377-82
references.pmid: 21785980
references.citation: Hum Genet. 2011 Jul;130(1):3-14
references.pmid: 21706342
references.citation: Mol Cancer. 2009 Jul 01;8:42
references.pmid: 19570220
references.citation: Neuro Oncol. 2011 Aug;13(8):866-79
references.pmid: 21798848
references.citation: Blood. 2008 Feb 15;111(4):2486-7; author reply 2487-8
references.pmid: 18263786
references.citation: Biopreserv Biobank. 2011 Jun;9(2):175-9
references.pmid: 24846264
references.citation: Biomark Med. 2010 Dec;4(6):895-903
references.pmid: 21133710
references.citation: J Clin Oncol. 2004 Mar 15;22(6):984-93
references.pmid: 14970185