title: Subchorionic hematomas are increased in early pregnancy in women taking low-dose aspirin.
abstract: To determine the frequency of subchorionic hematomas (SCH) in first-trimester ultrasound examinations of patients with infertility and recurrent pregnancy loss (RPL) and in patients from a general obstetric population. To determine if the method of assisted reproduction utilized or the use of anticoagulants, such as heparin and aspirin (ASA), influenced frequency of SCH.
  
  
  
  Prospective, cohort study.
  
  
  
  Fertility clinic and general obstetrics clinic.
  
  
  
  Five hundred and thirty-three women who were pregnant in the first-trimester.
  
  
  
  Not applicable.
  
  
  
  Frequencies of subchorionic hematomas in women based on diagnosis, use of anticoagulants, and fertility treatment.
  
  
  
  SCH were identified in 129/321 (40.2%) in the study group compared to 23/212 (10.9%) in the control group. Fertility diagnosis and the use of heparin did not appear to affect the frequency of SCH in the first trimester; however, SCH occurred at an almost four-fold increase in patients taking ASA compared to those not taking ASA, regardless of fertility diagnosis or method of fertility treatment.
  
  
  
  The use of ASA may be associated with an increased risk of developing a SCH during the first trimester. The increased frequencies of SCH in pregnancies of patients attending a fertility clinic compared to women from a general obstetrical practice was highly correlated with the use of ASA.
authors.affiliation: Department of Biochemistry and Molecular Biology, Rhodes College, Memphis, Tennessee.
authors.forename: Ashley
authors.initials: A
authors.lastname: Truong
authors.affiliation: Newport Beach Women's Wellness Center, Newport Beach, California.
authors.forename: M Mercedes
authors.initials: MM
authors.lastname: Sayago
authors.affiliation: Department of Obstetrics and Gynecology, Fertility Associates of Memphis, Vanderbilt University, Memphis, Tennessee. Electronic address: wkutteh@fertilitymemphis.com.
authors.forename: William H
authors.initials: WH
authors.lastname: Kutteh
authors.affiliation: Department of Obstetrics and Gynecology, Fertility Associates of Memphis, Vanderbilt University, Memphis, Tennessee.
authors.forename: Raymond W
authors.initials: RW
authors.lastname: Ke
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects*; D002823:Chorion / Q000000981:diagnostic imaging* / Q000187:drug effects; D015331:Cohort Studies; D005260:Female; D006406:Hematoma / Q000139:chemically induced / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced / Q000000981:diagnostic imaging*; D011446:Prospective Studies
chemical_list: D001241:Aspirin
keywords: anticoagulants; aspirin; infertility; recurrent pregnancy loss; subchorionic hematomas