title: [Genetic risk score: principle, methods and application].
abstract: Genetic risk score (GRS) is used for evaluating the effects of genetic susceptible factors in risk prediction models. Five methods are commonly used for GRS: i.e. simple count genetic risk score (SC-GRS), odds ratio weighted genetic risk score (OR-GRS), direct logistic regression genetic risk score (DL-GRS), polygenic genetic risk score (PG-GRS) and explained variance weighted genetic risk score (EV-GRS). This paper summarizes the models, application conditions, advantages and limitations of the five methods. The complexity of prediction models increased along with the inclusion of more susceptible SNPs, some method have been developed to solve the problems, but the effects of new methods needs further evaluation.
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
authors.forename: Juncheng
authors.initials: J
authors.lastname: Dai
authors.affiliation: Capital Bio Corporation.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Systems Biology Research Center, Tsinghua University School of Medicine.
authors.forename: Lan
authors.initials: L
authors.lastname: Xie
authors.affiliation: Capital Bio eHealth Corporation.
authors.forename: Liangbin
authors.initials: L
authors.lastname: Pan
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Email: hbshen@njmu.edu.cn.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008962:Models, Theoretical; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors