title: Serum cleaved tau protein and traumatic mild head injury: a preliminary study in the Thai population.
abstract: OBJECTIVE
  To determine the correlation between serum cleaved tau protein and traumatic mild head injury (MHI) (GCS 13-15).
  
  
  METHODS
  A prospective observational study was conducted. Blood specimens from 12 healthy persons and 44 adult patients with traumatic MHI were collected in the emergency department to measure the cleaved tau protein level using a Human Tau phosphoSerine 396 ELISA kit. A brain computed tomography (CT) scan was done in all patients. The serum cleaved tau protein level was considered positive at a cut-off point of 0.1 pg/ml. An intracranial lesion was defined as any abnormality detected by brain CT scan.
  
  
  RESULTS
  The mean age of the traumatic MHI patients was 34.9 ± 15.6 years (range 15-74). The median GCS was 15. The median time from injury to arrival at the emergency department was 30 min. There were 11 intracranial lesions detected by brain CT scan (25.0 %). Serum cleaved tau protein was not detected in either healthy or traumatic MHI patients.
  
  
  CONCLUSIONS
  As it was uncorrelated with traumatic MHI, serum cleaved tau protein proved to be an unreliable biomarker to use in the early detection of and decision-making for traumatic MHI patients at the emergency department.
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Songklanagarind Hospital, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand. Prasit0552002@yahoo.com.
authors.forename: P
authors.initials: P
authors.lastname: Wuthisuthimethawee
authors.affiliation: Department of Surgery, Faculty of Medicine, Songklanagarind Hospital, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Saeheng
authors.affiliation: Department of Surgery, Faculty of Medicine, Songklanagarind Hospital, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Oearsakul
keywords: Biomarker; Emergency department; Serum cleaved tau protein; Traumatic mild head injury
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