title: Paraproteinemic neuropathy: a practical review.
abstract: The term paraproteinemic neuropathy describes a heterogeneous set of neuropathies characterized by the presence of homogeneous immunoglobulin in the serum. An abnormal clonal proliferation of B-lymphocytes or plasma cells, which may or may not occur in the context of a hematologic malignancy, produces the immunoglobulins in excess. If malignancy is identified, treatment should be targeted to the neoplasm. Most cases, however, occur as monoclonal gammopathy of undetermined significance. Few prospective, randomized, placebo-controlled trials are available to inform the management of paraproteinemic neuropathies. Clinical experience combined with data from smaller, uncontrolled studies provide a basis for recommendations, which depend on the specific clinical setting in which the paraprotein occurs. In this review, we provide a clinically practical approach to diagnosis and management of such patients.
authors.affiliation: University of Southern California, Keck School of Medicine, Los Angeles County Medical Center, Medical Director PIH Health-Whittier Stroke Program, Neurology Consultants Medical Group, 12401 Washington Blvd., Whittier, CA, 90602, USA. rison@usc.edu.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Rison
authors.affiliation: University of Southern California, Keck School of Medicine, Los Angeles County Medical Center, 1520 San Pablo Street Suite 3000, Los Angeles, CA, 90033, USA. sbeydoun@usc.edu.
authors.forename: Said R
authors.initials: SR
authors.lastname: Beydoun
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008019:Life Style; D010265:Paraproteinemias / Q000150:complications / Q000628:therapy*; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000628:therapy*; D010956:Plasmapheresis; D033581:Stem Cell Transplantation; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D000700:Analgesics; D000970:Antineoplastic Agents; D018691:Excitatory Amino Acid Antagonists; D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D042461:Vascular Endothelial Growth Factor A
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