title: ABCB1 polymorphisms associated with osteonecrosis of the femeral head.
abstract: OBJECTIVE
  This case-control study was conducted to investigate the relation of ATP-binding cassette subfamily B member 1 (ABCB1) C1236T and C3435T polymorphisms and non-traumatic osteonecrosis of the femeral head (ONFH).
  
  
  METHODS
  We gathered 113 ONFH patients and 116 controls in the study. The polymorphisms of ABCB1 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technology. Odds ratio (OR) with 95% confidence interval (CI) were adopted to analyze the correlation between ABCB1 polymorphisms and ONFH.
  
  
  RESULTS
  In the study, we found that the frequency of C3435T TT genotype was much lower in case group, compared with that of controls (17.7% vs. 23.3%). Moreover, OR and 95% CI values indicated that C3435T TT genotype served as a protective factor for ONFH (OR=0.34, 95% CI=0.15-0.75). Meanwhile, the risk for the T allele carriers was much lower than C allele (OR=0.60, 95% CI=0.42-0.87). However, C1236T polymorphism showed no significant effects on the pathogenesis of ONFH. In the haplotype analysis, T-T haplotype appeared to be an inhibitor for ONFH (OR=0.45, 95% CI=0.23-0.87).
  
  
  CONCLUSIONS
  Based on the results, ABCB1 polymorphisms were associated with the risk for ONFH.
authors.affiliation: Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine China.
authors.forename: Zongyu
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine China.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine China.
authors.forename: Huaiying
authors.initials: H
authors.lastname: Liu
authors.affiliation: 1st Affiliated Hospital of Suzhou University China.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Shi
authors.affiliation: 1st Affiliated Hospital of Suzhou University China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Li
authors.affiliation: 1st Affiliated Hospital of Suzhou University China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Jiang
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005271:Femur Head Necrosis / Q000175:diagnosis / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B
keywords: ABCB1; ONFH; polymorphisms
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