title: Brief Report: Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART.
abstract: HIV-infected men who have sex with men are nearly universally coinfected with cytomegalovirus (CMV). In this study of 45 HIV-infected men who have sex with men virologically suppressed on ART, we found that presence of seminal CMV DNA shedding and higher levels of systemic cellular HIV RNA transcription were both independently associated with increased PD-1 expression on circulating CD4 T cells, but not with higher levels of senescent (CD57) T cells. In addition, greater HIV RNA transcription was associated with lower CD57 expression on CD8 T cells. Although causality cannot be inferred from this retrospective study, these results suggest that asymptomatic CMV replication and residual cellular HIV transcription may contribute to persistent immune dysregulation during suppressive ART.
authors.affiliation: *La Jolla Institute for Allergy and Immunology, La Jolla, CA;†University of California, San Diego, CA;‡Veterans Affairs San Diego Healthcare System, San Diego, CA;§Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA; and‖University of Southern California, Keck School of Medicine, Los Angeles, CA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Dan
authors.forename: Marta
authors.initials: M
authors.lastname: Massanella
authors.forename: Davey M
authors.initials: DM
authors.lastname: Smith
authors.forename: Celsa A
authors.initials: CA
authors.lastname: Spina
authors.forename: Rachel
authors.initials: R
authors.lastname: Schrier
authors.forename: Eric S
authors.initials: ES
authors.lastname: Daar
authors.forename: Michael P
authors.initials: MP
authors.lastname: Dube
authors.forename: Sheldon R
authors.initials: SR
authors.lastname: Morris
authors.forename: Sara
authors.initials: S
authors.lastname: Gianella
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018959:CD57 Antigens / Q000187:drug effects / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D060085:Coinfection; D003430:Cross-Sectional Studies; D003587:Cytomegalovirus / Q000235:genetics* / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D004279:DNA, Viral; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics* / Q000276:immunology; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000096:biosynthesis / Q000235:genetics; D012189:Retrospective Studies; D018570:Risk Assessment; D012661:Semen / Q000821:virology; D014158:Transcription, Genetic; D017201:Virus Shedding
chemical_list: D019380:Anti-HIV Agents; D018959:CD57 Antigens; D004279:DNA, Viral; D012367:RNA, Viral
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