title: German guidelines for the diagnosis and therapy of localized scleroderma.
abstract: Localized scleroderma designates a heterogeneous group of sclerotic skin disorders. Depending on the subtype, severity, and site affected, adjacent structures such as adipose tissue, muscles, joints, and bones may be involved. This is an update of the existing German AWMF (Association of the Scientific Medical Societies in Germany) guidelines (classification: S2k). These guidelines provide an overview of the definition, epidemiology, classification, pathogenesis, laboratory workup, histopathology, clinical scoring systems, as well as imaging and device-based workup of localized scleroderma. Moreover, consensus-based recommendations are given on the management of localized scleroderma depending on its clinical subtype. Treatment recommendations are presented in a therapeutic algorithm. No financial support was given by any pharmaceutical company. The guidelines are valid until July 2019.
authors.affiliation: Department of Dermatology, Venereology, and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, Oberhausen, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kreuter
authors.affiliation: Department of Dermatology and Venereology, University Hospital Cologne, Cologne, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Krieg
authors.affiliation: Department of Dermatology, Venereology, and Allergology, Charité - University Medical Center Berlin, Berlin, Germany.
authors.forename: Margitta
authors.initials: M
authors.lastname: Worm
authors.affiliation: Department of Dermatology and Allergology, University Hospital Bonn, Bonn, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Wenzel
authors.affiliation: Department of Dermatology and Venereology, University Hospital Cologne, Cologne, Germany.
authors.forename: Pia
authors.initials: P
authors.lastname: Moinzadeh
authors.affiliation: Interdisciplinary Center for Clinical Studies (IZKS), University Medical Center Mainz, Mainz, Germany.
authors.forename: Annegret
authors.initials: A
authors.lastname: Kuhn
authors.affiliation: Department of Dermatology and Venereology, University Hospital Graz, Graz, Austria.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Aberer
authors.affiliation: Department of Dermatology and Allergology, University Hospital Ulm, Ulm, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Scharffetter-Kochanek
authors.affiliation: Department of General Pediatrics, Asklepios Hospital, St. Augustin, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Horneff
authors.affiliation: Emma Reil, Scleroderma Support Group, Heilbronn, Germany.
authors.forename: Emma
authors.initials: E
authors.lastname: Reil
authors.affiliation: Department of Dermatology, Venereology, und Allergology, University Hospital Frankfurt and Work Group EbM Frankfurt, Institute for General Medicine, Johann Wolfgang Goethe University Frankfurt, Frankfurt am Main, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Weberschock
authors.affiliation: Department of Dermatology and Venereology, University Hospital Cologne, Cologne, Germany.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Hunzelmann
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D003880:Dermatology / Q000592:standards*; D046169:Dermoscopy / Q000592:standards*; D005858:Germany; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000592:standards*; D017410:Practice Guidelines as Topic; D012594:Scleroderma, Localized / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents