title: Primary Extra-Gonadal Retroperitoneal Seminoma, Clinically Mimicking Sarcoma.
abstract: Extra-gonadal Germ cell tumours (EGCTs) are germ cell tumours that are found in locations other than the gonads. These tumours are seen in young males in the midline, mostly in the mediastinum followed by retroperitoneum, pineal gland, and sacrococcygeal area. While most of these are non-seminomatous, few are seminomatous. We present here a case report of a 25-year-old, mentally retarded male patient, with bilaterally normal testes, who presented with a huge mass in abdomen. The ultrasound and CECT (Contrast Enhanced Computerized Tomography) scan done showed two large retroperitoneal masses, which on FNAC (Fine Needle Aspiration Cytology) suggested germ cell tumour. Surgical resection was done and the subsequent histopathological examination provided the diagnosis of seminoma, which was further confirmed by PAS (Periodic Acid Schiff) staining and Immunohistochemistry for PLAP (Placental Alkaline Phosphatase). Retroperitoneum is a common site for sarcomas, which also present as huge, bulky masses. Thus, EGCTs should be considered in the differential diagnosis of a soft-tissue mass in abdomen, especially arising in the retroperitoneum.
authors.affiliation: Post Graduate Student, Department of Pathology, Government Medical College , Amritsar, Punjab, India .
authors.forename: Davsheen
authors.initials: D
authors.lastname: Bedi
authors.affiliation: Associate Professor, Department of Pathology, Government Medical College , Amritsar, Punjab, India .
authors.forename: Permeet Kaur
authors.initials: PK
authors.lastname: Bagga
authors.affiliation: Professor, Department of Pathology, Government Medical College , Amritsar, Punjab, India .
authors.forename: Amarjit
authors.initials: A
authors.lastname: Singh
authors.affiliation: Post Graduate Student, Department of Pathology, Government Medical College , Amritsar, Punjab, India .
authors.forename: Vaishali
authors.initials: V
authors.lastname: Verma
keywords: Abdominal soft-tissue tumour; Germ cell tumour; Retroperitoneal soft tissue tumour
references.citation: Eur J Cancer. 1993;29A(7):1002-5
references.pmid: 7684595
references.citation: Adv Anat Pathol. 2007 Mar;14(2):69-92
references.pmid: 17471115
references.citation: Hum Pathol. 2006 Apr;37(4):477-80
references.pmid: 16564924
references.citation: Cancer. 2001 Apr 1;91(7):1394-401
references.pmid: 11283942
references.citation: Arch Pathol Lab Med. 2007 Aug;131(8):1267-80
references.pmid: 17683189
references.citation: Am J Clin Pathol. 2007 Nov;128(5):767-75
references.pmid: 17951198