title: Assessment of trabecular bone score (TBS) in overweight/obese men: effect of metabolic and anthropometric factors.
abstract: The "trabecular bone score" (TBS) indirectly explores bone quality, independently of bone mineral density (BMD). We investigated the effects of anthropometric and metabolic parameters on TBS in 87 overweight/obese men. We assessed BMD and TBS by DXA, and some parameters of glucose metabolism, sex-and calciotropic hormone levels. Regression models were adjusted for either age and BMI, or age and waist circumference, or age and waist/hip ratio, also considering BMI >35 (y/n) and metabolic syndrome (MS) (y/n). Correlations between TBS and parameters studied were higher when correcting for waist circumference, although not significant in subjects with BMI >35. The analysis of covariance showed that the same model always had a higher adjusted r-square index. BMD at lumbar spine and total hip, fasting glucose, bioavailable testosterone, and sex hormone-binding globulin are the only covariates having a significant effect (p < 0.05) on the variations of TBS. The presence of MS negatively affected only the association between TBS and BMD at total hip. We did not find any significant effect of BMI >35 on TBS values or significant interaction terms between each covariate and either BMI >35 or the presence of MS. Obesity negatively affected TBS, despite unchanged BMD. Alterations of glucose homeostasis and sex hormone levels seem to influence this relationship, while calciotropic hormones have no role. The effect of waist circumference on TBS is more pronounced than that of BMI.
authors.affiliation: Department of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, "Sapienza" University of Rome, Rome, Italy. romagnoli.elisabetta@fastwebnet.it.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Romagnoli
authors.affiliation: Department of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Lubrano
authors.affiliation: Unit of Internal Medicine, ''Casa Sollievo della Sofferenza'' Hospital I.R.C.C.S., San Giovanni Rotondo, FG, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Carnevale
authors.affiliation: Department of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Costantini
authors.affiliation: Faculty of Economics, UNINT University, Rome, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Nieddu
authors.affiliation: Department of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Morano
authors.affiliation: Endocrinology Unit, Department of Movement, Human and Health Sciences, University of "Foro Italico", Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Migliaccio
authors.affiliation: Department of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Gnessi
authors.affiliation: Department of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lenzi
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D000328:Adult; D000368:Aged; D000886:Anthropometry; D001786:Blood Glucose; D015519:Bone Density / Q000502:physiology*; D000071556:Cancellous Bone / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000000981:diagnostic imaging*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000000981:diagnostic imaging; D050177:Overweight / Q000097:blood / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood
chemical_list: D001786:Blood Glucose; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone
keywords: Bone quality; Men; Metabolic syndrome; Obesity; TBS
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