title: Progress toward a Respiratory Syncytial Virus Vaccine.
abstract: In accompanying papers (P. L. Acosta, M. T. Caballero, and F. P. Polack, Clin Vaccine Immunol 23:189-195, 2016, http://dx.doi.org/10.1128/CVI.00609-15; M. Vissers, I. M. L. Ahout, M. I. de Jonge, and G. Ferwerda, Clin Vaccine Immunol 23:243-245, 2016, http://dx.doi.org/10.1128/CVI.00590-15) in this issue of Clinical and Vaccine Immunology, the history of and immune mechanisms underlying vaccine-enhanced respiratory syncytial virus (RSV) disease and of investigations of mucosal antibodies and their association with viral load in RSV-infected children, respectively, are described. This commentary discusses RSV vaccine candidates, target populations, and the challenges associated with achieving a safe and effective vaccine.
authors.affiliation: Department of Medicine and Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA kneuzil@medicine.umaryland.edu.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Neuzil
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology; D006801:Humans; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology; D022261:Respiratory Syncytial Virus Vaccines / Q000276:immunology*; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D019562:Viral Load / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D022261:Respiratory Syncytial Virus Vaccines
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