title: Graph theoretical analysis of brain connectivity in phantom sound perception.
abstract: Tinnitus is a phantom sound commonly thought of to be produced by the brain related to auditory deafferentation. The current study applies concepts from graph theory to investigate the differences in lagged phase functional connectivity using the average resting state EEG of 311 tinnitus patients and 256 healthy controls. The primary finding of the study was a significant increase in connectivity in beta and gamma oscillations and a significant reduction in connectivity in the lower frequencies for the tinnitus group. There also seems to be parallel processing of long-distance information between delta, theta, alpha1 and gamma frequency bands that is significantly stronger in the tinnitus group. While the network reorganizes into a more regular topology in the low frequency carrier oscillations, development of a more random topology is witnessed in the high frequency oscillations. In summary, tinnitus can be regarded as a maladaptive 'disconnection' syndrome, which tries to both stabilize into a regular topology and broadcast the presence of a deafferentation-based bottom-up prediction error as a result of a top-down prediction.
authors.affiliation: Lab for Clinical &Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, USA.
authors.forename: Anusha
authors.initials: A
authors.lastname: Mohan
authors.affiliation: Department of Surgical Sciences, Section of Neurosurgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
authors.forename: Dirk
authors.initials: D
authors.lastname: De Ridder
authors.affiliation: Lab for Clinical &Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, USA.
authors.forename: Sven
authors.initials: S
authors.lastname: Vanneste
mesh_terms: D000328:Adult; D000368:Aged; D001307:Auditory Perception; D001921:Brain / Q000503:physiopathology*; D058256:Brain Waves; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology*; D014012:Tinnitus / Q000503:physiopathology*
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