title: Severe adverse drug reactions.
abstract: Severe cutaneous adverse reactions (SCARs) can present in a multitude of ways including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, and acute generalised exanthematous pustulosis. While the prognosis and therapy for these conditions may vary, it is crucial that the culprit drug is identified and withheld early as this can influence patient outcome. Mainstay of management is by supportive therapy. In all SCARs, long-term sequelae which may not be apparent initially can be debilitating and cause lasting impact on the quality of life of survivors.
authors.affiliation: King's College Hospital, London, UK yteo20@gmail.com.
authors.forename: Ying Xin
authors.initials: YX
authors.lastname: Teo
authors.affiliation: Department of Dermatology, King's College Hospital, London, UK.
authors.forename: Sarah Anne
authors.initials: SA
authors.lastname: Walsh
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000209:etiology*; D064420:Drug-Related Side Effects and Adverse Reactions; D004802:Eosinophilia; D005076:Exanthema; D005260:Female; D006801:Humans; D008297:Male; D011788:Quality of Life; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
keywords: Severe adverse drug reactions; Stevens–Johnson syndrome; acute generalised exanthematous pustulosis; drug reaction with eosinophilia and systemic symptoms; toxic epidermal necrolysis
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