title: RNA binding proteins implicated in Xist-mediated chromosome silencing.
abstract: Chromosome silencing by Xist RNA occurs in two steps; localisation in cis within the nuclear matrix to form a domain that corresponds to the territory of the inactive X chromosome elect, and transduction of silencing signals from Xist RNA to the underlying chromatin. Key factors that mediate these processes have been identified in a series of recent studies that harnessed comprehensive proteomic or genetic screening strategies. In this review we discuss these findings in light of prior knowledge both of Xist-mediated silencing and known functions/properties of the novel factors.
authors.affiliation: Dept. of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
authors.forename: Benoit
authors.initials: B
authors.lastname: Moindrot
authors.affiliation: Dept. of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address: neil.brockdorff@bioch.ox.ac.uk.
authors.forename: Neil
authors.initials: N
authors.lastname: Brockdorff
mesh_terms: D000818:Animals; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000378:metabolism; D006801:Humans; D008957:Models, Genetic; D062085:RNA, Long Noncoding / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D049951:X Chromosome Inactivation / Q000235:genetics*
chemical_list: D034441:Heterogeneous-Nuclear Ribonucleoproteins; D062085:RNA, Long Noncoding; D016601:RNA-Binding Proteins; C077885:XIST non-coding RNA
keywords: Chromatin; Epigenetic; Non-coding RNA; X chromosome inactivation; Xist