title: Electrochemical and in vitro neuronal recording characteristics of multi-electrode arrays surface-modified with electro-co-deposited gold-platinum nanoparticles.
abstract: In order to complement the high impedance electrical property of gold nanoparticles (Au NPs) we have performed electro-co-deposition of gold-platinum nanoparticles (Au-Pt NPs) onto the Au multi-electrode array (MEA) and modified the Au-Pt NPs surface with cell adhesive poly-D-lysine via thiol chemistry based covalent binding. The Au-Pt NPs were analyzed to have bimetallic nature not the mixture of Au NPs and Pt NPs by X-ray diffraction analysis and to have impedance value (4.0 × 10(4) Ω (at 1 kHz)) comparable to that of Pt NPs. The performance of Au-Pt NP-modified MEAs was also checked in relation to neuronal signal recording. The noise level in Au-Pt NP-modified MEAs was lower than in that of Au NP-modified MEA.
authors.affiliation: Synapse Device Creative Research Center, Electronics and Telecommunications Research Institute, 218 Gajeong-ro, Yuseong-gu, Daejeon, 305-700, Republic of Korea.
authors.forename: Yong Hee
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Synapse Device Creative Research Center, Electronics and Telecommunications Research Institute, 218 Gajeong-ro, Yuseong-gu, Daejeon, 305-700, Republic of Korea.
authors.forename: Ah Young
authors.initials: AY
authors.lastname: Kim
authors.affiliation: Synapse Device Creative Research Center, Electronics and Telecommunications Research Institute, 218 Gajeong-ro, Yuseong-gu, Daejeon, 305-700, Republic of Korea.
authors.forename: Gook Hwa
authors.initials: GH
authors.lastname: Kim
authors.affiliation: Synapse Device Creative Research Center, Electronics and Telecommunications Research Institute, 218 Gajeong-ro, Yuseong-gu, Daejeon, 305-700, Republic of Korea.
authors.forename: Young Hwan
authors.initials: YH
authors.lastname: Han
authors.affiliation: Synapse Device Creative Research Center, Electronics and Telecommunications Research Institute, 218 Gajeong-ro, Yuseong-gu, Daejeon, 305-700, Republic of Korea.
authors.forename: Myung-Ae
authors.initials: MA
authors.lastname: Chung
authors.affiliation: Synapse Device Creative Research Center, Electronics and Telecommunications Research Institute, 218 Gajeong-ro, Yuseong-gu, Daejeon, 305-700, Republic of Korea. jungpol@etri.re.kr.
authors.forename: Sang-Don
authors.initials: SD
authors.lastname: Jung
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D055664:Electrochemical Techniques; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010984:Platinum / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction
chemical_list: D010984:Platinum; D006046:Gold
keywords: Au-Pt nanoparticles; Electro-co-deposition; Multi-electrode array; Neuronal signal recording