title: Association between central and peripheral blood pressure and periodontal disease in patients with a history of myocardial infarction.
abstract: BACKGROUND
  Central and peripheral blood pressure (BP) and periodontal disease (PD) are considered to be related to the risk of cardiovascular disease. However, there is scarce evidence on the association between chronic PD and BP.
  
  
  OBJECTIVE
  The aim of the study was to assess the relation between chronic PD, antibodies against Porphyromonas gingivalis (P.g.) gingipains and central and peripheral BP in high-risk patients with previous myocardial infarction.
  
  
  METHODS
  We examined 99 patients (71 men and 28 women) 6 to 18 months after myocardial infarction. The periodontal status was assessed using the Community Periodontal Index (CPI). BP was measured noninvasively using the Mobil-O-Graph device. Antibody titers against P.g. gingipains were determined by an enzyme-linked immunosorbent assay. The association between CPI and BP was assessed using logistic regression models.
  
  
  RESULTS
  The mean age of participants was 60.5 ±8.7 years. After the adjustment for age, sex, smoking, diabetes, number of antihypertensive drugs, hypercholesterolemia, body mass index, and left ventricular ejection fraction, an association was found between central and peripheral BP and the CPI. Patients from the CPI 3 + 4 group were found to have almost 3 times higher odds of central BP of 130/90 mmHg or higher and more than 3 times higher odds of peripheral BP of 140/90 mmHg or higher compared with patients from the CPI 1 + 2 group.
  
  
  CONCLUSIONS
  The severity of PD was associated with increased central and peripheral BP. The association between BP and PD may partially explain the cardiovascular risk related to chronic PD. Proteolytic activity of P.g. gingipains was not associated with BP.
authors.forename: Radosław
authors.initials: R
authors.lastname: Łysek
authors.forename: Piotr
authors.initials: P
authors.lastname: Jankowski
authors.forename: Maciej
authors.initials: M
authors.lastname: Polak
authors.forename: Krystyna
authors.initials: K
authors.lastname: Szafraniec
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Micek
authors.forename: Renata
authors.initials: R
authors.lastname: Wolfshaut-Wolak
authors.forename: Anna
authors.initials: A
authors.lastname: Łukaszewska
authors.forename: Thomas
authors.initials: T
authors.lastname: Weber
authors.forename: Danuta
authors.initials: D
authors.lastname: Czarnecka
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pająk
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D001794:Blood Pressure; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction; D010510:Periodontal Diseases / Q000097:blood / Q000503:physiopathology*; D016966:Porphyromonas gingivalis / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial