title: Cornelia de Lange and Ehlers-Danlos: comorbidity of two rare syndromes.
abstract: We present a case of a young adult with both Cornelia de Lange syndrome and Ehlers-Danlos syndrome. The patient showed non-verbal autism, intellectual disability and severe/intractable self-harming behaviours that led to a life-threatening complication (ie, septicaemia). A significant reduction in the self-harming behaviours was attained in a multidisciplinary neurobehavioural inpatient unit after addressing all causes of somatic pains, managing pain using level II and III analgesics, stabilising the patient's mood, limiting the iatrogenic effects of multiple prescriptions and offering a specific psychoeducational approach.
authors.affiliation: Department of Child and Adolescent Psychiatry, Reference Centre for Rare Psychiatric Diseases, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Cora
authors.initials: C
authors.lastname: Cravero
authors.affiliation: Department of Child and Adolescent Psychiatry, Reference Centre for Rare Psychiatric Diseases, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Guinchat
authors.affiliation: Unit of Dermatology, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Barete
authors.affiliation: Department of Child and Adolescent Psychiatry, Reference Centre for Rare Psychiatric Diseases, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France INSERM U669, Maison de Solenn, Paris, France.
authors.forename: Angèle
authors.initials: A
authors.lastname: Consoli
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D015897:Comorbidity; D003635:De Lange Syndrome / Q000150:complications* / Q000523:psychology / Q000628:therapy; D003863:Depression / Q000209:etiology* / Q000523:psychology / Q000628:therapy; D004535:Ehlers-Danlos Syndrome / Q000150:complications* / Q000523:psychology / Q000628:therapy; D005473:Fluoxetine / Q000627:therapeutic use; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D008297:Male; D008405:Massage / Q000379:methods; D009020:Morphine / Q000627:therapeutic use; D010146:Pain / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D059408:Pain Management / Q000379:methods*; D000066553:Problem Behavior / Q000523:psychology; D012652:Self Mutilation / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D009020:Morphine
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