title: Primary central nervous system lymphoma in daily practice and the role of autologous stem cell transplantation in relapsed disease: A retrospective multicenter study.
abstract: We investigated the course of 54 patients presenting with primary central nervous system lymphoma, who were treated in daily practice. The patients were treated with chemotherapy and/or radiotherapy and/or intrathecal chemotherapy. At a median follow-up period of 23 months (range 1-71), median relapse-free survival (RFS) and overall survival (OS) were not reached. Estimated 2-year RFS and OS rates were 42% and 48%, respectively. Ten relapsed PCNSL patients underwent ASCT. Complete remission rate of these patients was 40%, with 20% treatment-related mortality. Estimated 2-year RFS and OS rates were 37% and 40%, respectively. The prognosis of patients with PCNSL, who received off-study treatment, is still dismal.
authors.affiliation: Department of Hematology, Inönü University Medical Faculty, Malatya, Turkey. Electronic address: erkurtali@hotmail.com.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Erkurt
authors.affiliation: Department of Hematology, Inönü University Medical Faculty, Malatya, Turkey.
authors.forename: Ilhami
authors.initials: I
authors.lastname: Berber
authors.affiliation: Hematology and HCT Clinic, Ankara Oncology Hospital, Ankara, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Tekgündüz
authors.affiliation: Department of Hematology, Pamukkale University Medical Faculty, Denizli, Turkey.
authors.forename: Mehmet Hilmi
authors.initials: MH
authors.lastname: Dogu
authors.affiliation: Hematology Division, Kayseri Trainer and Research Hospital, Kayseri, Turkey.
authors.forename: Serdal
authors.initials: S
authors.lastname: Korkmaz
authors.affiliation: Department of Hematology, Yüzüncü Yıl University Medical Faculty, Van, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Demir
authors.affiliation: Department of Hematology, Antep University Medical Faculty, Gaziantep, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: Department of Hematology, Osmangazi University Medical Faculty, Eskişehir, Turkey.
authors.forename: Olga Meltem
authors.initials: OM
authors.lastname: Akay
authors.affiliation: Department of Hematology, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Ciğdem
authors.initials: C
authors.lastname: Pala
authors.affiliation: Department of Hematology, Atatürk University Medical Faculty, Erzurum, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Bilen
authors.affiliation: Department of Hematology, Inönü University Medical Faculty, Malatya, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Kaya
authors.affiliation: Department of Hematology, Pamukkale University Medical Faculty, Denizli, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Sari
authors.affiliation: Department of Hematology, Cumhuriyet University Medical Faculty, Sivas, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sencan
authors.affiliation: Department of Hematology, Inönü University Medical Faculty, Malatya, Turkey.
authors.forename: Irfan
authors.initials: I
authors.lastname: Kuku
authors.affiliation: Hematology and HCT Clinic, Ankara Oncology Hospital, Ankara, Turkey; Department of Internal Medicine, Division of Hematology, Yıldırım Beyazıt University Medical Faculty, Ankara, Turkey.
authors.forename: Fevzi
authors.initials: F
authors.lastname: Altuntaş
authors.affiliation: Hematology and HCT Clinic, Ankara Oncology Hospital, Ankara, Turkey.
authors.forename: Mehmet Sinan
authors.initials: MS
authors.lastname: Dal
authors.affiliation: Department of Hematology, Celal Bayar University Medical Faculty, Manisa, Turkey.
authors.forename: Ismet
authors.initials: I
authors.lastname: Aydogdu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016543:Central Nervous System Neoplasms / Q000628:therapy*; D003710:Demography; D006801:Humans; D008223:Lymphoma / Q000628:therapy*; D008875:Middle Aged; D010818:Practice Patterns, Physicians'; D012008:Recurrence; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous; D055815:Young Adult
keywords: Autologous stem cell transplantation; CNS lymphoma; High-dose chemotherapy; Methotrexate; PCNSL