title: Skull metastasis from follicular thyroid carcinoma: report of three cases and review of literature.
abstract: Three patients' medical history, clinical manifestation, imaging characteristic, therapy and prognosis of calvaria metastasis from follicular thyroid carcinoma (FTC) in our hospital were retrospectively analyzed by reviewing medical literature. In case one, the tumor in frontal bone and fossa orbital was total resected, no further treatment was performed, the patient gave up on therapy and died of extensive metastasis at 22 months after the initial operation. In case two, the tumor in parietal and occipital bone was total resected, the subtotal resection of bilateral thyroid gland and isthmus was performed and combined with therapy of Levothyroxine and (131)I radio-iodine therapy, no evidence of tumor recurrence at 30 months after the primary operation. In case three, the tumor in occipital bone was gross total resected, total resection of bilateral thyroid gland and clearance of lymph node was performed after two months, adjunctive therapy with Levothyroxine, (131)I radio-iodine and skull radiotherapy, no evidence of tumor recurrence at 21 months after the primary operation. Correct diagnosis of calvaria metastasis from FTC preoperative is difficult because it's rarity, patients can survive for years after synthetic therapy including total resection of metastatic tumor, radical operation of thyroid carcinoma, adjunctive therapy of Levothyroxine, (131)I radio-iodine and skull radiotherapy.
authors.affiliation: Department of Neurosurgery, Yi-Ji Shan Hospital of Wannan Medical College Wuhu, Anhui, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Pathology, Yi-Ji Shan Hospital of Wannan Medical College Wuhu, Anhui, China.
authors.forename: Sufen
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Yi-Ji Shan Hospital of Wannan Medical College Wuhu, Anhui, China.
authors.forename: Xintong
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Yi-Ji Shan Hospital of Wannan Medical College Wuhu, Anhui, China.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Shao
authors.affiliation: Department of Neurosurgery, Yi-Ji Shan Hospital of Wannan Medical College Wuhu, Anhui, China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Yi-Ji Shan Hospital of Wannan Medical College Wuhu, Anhui, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Neurosurgery, Yi-Ji Shan Hospital of Wannan Medical College Wuhu, Anhui, China.
authors.forename: Shanshui
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Yi-Ji Shan Hospital of Wannan Medical College Wuhu, Anhui, China.
authors.forename: Xianwen
authors.initials: X
authors.lastname: Pan
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D016371:Cranial Irradiation; D003399:Craniotomy; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D012888:Skull Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy; D013974:Thyroxine / Q000008:administration & dosage; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D013974:Thyroxine
keywords: Thyroid carcinoma; calvaria; follicular thyroid carcinoma; papillary thyroid carcinoma; skull base
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