title: Concentration analysis of hypoxi-inducible factor-1α; and vascular endothelial growth factor in patients with aortic aneurysm at different stages and its clinical significance.
abstract: This study aims to investigate serum concentration of hypoxia inducible factor-1α; (HIF-1α) and vascular endothelial growth factor (VEGF) in patients with aneurysms at different stages, and to determine critical role in early diagnosis and evaluation of severity. A cohort of 102 cases of patients diagnosed as aneurysms during May 2012 to April 2015 in our hospital were retrospectively analyzed. Patients were divided into early stage group (n=32), mid-term group (n=34), and late stage group (n=36) according to severity of aneurysms. The measurement of concentration of HIF-1α and VEGF was detected by Enzyme-linked immunosorbent assays (ELISA). Serum level of HIF-1α; and VEGF was compared among different groups. The results showed that serum concentrations of HIF-1α (t=25.53, P<0.05) and VEGF (t=12.10, P<0.05) in early stage group were significantly higher than those in normal group. Serum concentrations of HIF-1α (t=25.63, P<0.05) and VEGF (t=9.71, P<0.05) in the mid-term group were significantly higher than those in the early stage group. Serum concentrations of HIF-1α (t=14.61, P<0.05) and VEGF (t=21.42, P<0.05) in the late stage group were significantly higher than those in the mid-term group. In conclusion, serum HIF-1α and VEGF has clinical value of early diagnosis and assessment of disease severity.
authors.affiliation: Shaoxing Hospital of Zhejiang University Vascular Surgery Department of Shaoxing People's Hospital Shaoxing China.
authors.forename: M
authors.initials: M
authors.lastname: Xu
authors.affiliation: Shaoxing Hospital of Zhejiang University Vascular Surgery Department of Shaoxing People's Hospital Shaoxing China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Shaoxing Hospital of Zhejiang University Vascular Surgery Department of Shaoxing People's Hospital Shaoxing China.
authors.forename: L
authors.initials: L
authors.lastname: Tang
authors.affiliation: Shaoxing Hospital of Zhejiang University Vascular Surgery Department of Shaoxing People's Hospital Shaoxing China huanghlshaox@yeah.net.
authors.forename: H
authors.initials: H
authors.lastname: Huang
mesh_terms: D001014:Aortic Aneurysm / Q000097:blood* / Q000175:diagnosis*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A