title: Generalized mesh-based Monte Carlo for wide-field illumination and detection via mesh retessellation.
abstract: Monte Carlo methods are commonly used as the gold standard in modeling photon transport through turbid media. With the rapid development of structured light applications, an accurate and efficient method capable of simulating arbitrary illumination patterns and complex detection schemes over large surface area is in great need. Here we report a generalized mesh-based Monte Carlo algorithm to support a variety of wide-field illumination methods, including spatial-frequency-domain imaging (SFDI) patterns and arbitrary 2-D patterns. The extended algorithm can also model wide-field detectors such as a free-space CCD camera. The significantly enhanced flexibility of source and detector modeling is achieved via a fast mesh retessellation process that combines the target domain and the source/detector space in a single tetrahedral mesh. Both simulations of complex domains and comparisons with phantom measurements are included to demonstrate the flexibility, efficiency and accuracy of the extended algorithm. Our updated open-source software is provided at http://mcx.space/mmc.
authors.affiliation: Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.
authors.forename: Ruoyang
authors.initials: R
authors.lastname: Yao
authors.affiliation: Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.
authors.forename: Xavier
authors.initials: X
authors.lastname: Intes
authors.affiliation: Department of Bioengineering, Northeastern University, 360 Huntington Ave, Boston, MA 02115, USA.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Fang
keywords: (070.6120) Spatial light modulators; (170.3660) Light propagation in tissues; (170.5280) Photon migration; (170.6920) Time-resolved imaging; (170.7050) Turbid media
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