title: Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura.
abstract: This study aimed to investigate the dysfunctional ascending/descending pain pathways at the thalamic level in patients with migraine without aura (MWoA) using the effective connectivity analysis of the resting-state functional MRI. Twenty MWoA and 25 matched healthy controls participated in the resting-state functional MRI scans. The directional interactions between the posterior thalamus (PTH) and other brain regions were investigated using the Granger causality analysis and choosing bilateral PTH as two individual seeds. Pearson's correlation analysis was carried out between the abnormal effective connectivity and the headache duration and pain intensity of MWoA. Compared with healthy controls, MWoA showed decreased inflows to the bilateral PTH from the ventromedial prefrontal cortex and the left precuneus/posterior cingulate cortex, decreased outflow from the left PTH to the ipsilateral dorsomedial prefrontal cortex, and increased inflow to the right PTH from the ipsilateral dorsolateral prefrontal cortex. In addition, the abnormal inflows to the right PTH from the ventromedial prefrontal cortex and the right dorsolateral prefrontal cortex correlated positively with the headache duration and pain intensity, respectively. The abnormal ascending/descending pain pathways between the thalamus and these cortical regions indicate a disrupted pain modulation in affective and sensory domains, which suggests a disequilibrium of pain inhibition and facilitation in MWoA. These findings may help to shed light on the pathophysiologic mechanisms of migraine.
authors.affiliation: aDepartment of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University bDepartment of Radiology, Huaxi MR Research Center (HMRRC) cDepartment of Neurology, West China Hospital of Sichuan University dDepartment of Psychology, School of Public Administration, Sichuan University, Chengdu, People's Republic of China eNeuroimaging Center, University of Maryland, College Park, Maryland.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Wang
authors.initials: W
authors.lastname: Zhan
authors.forename: Qin
authors.initials: Q
authors.lastname: Chen
authors.forename: Ning
authors.initials: N
authors.lastname: Chen
authors.forename: Junpeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.forename: Junran
authors.initials: J
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Huang
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
mesh_terms: D000328:Adult; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020326:Migraine without Aura / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology; D012146:Rest; D012720:Severity of Illness Index; D012815:Signal Processing, Computer-Assisted; D013788:Thalamus / Q000503:physiopathology*; D055815:Young Adult
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