title: Callous traits in children with and without conduct problems predict reduced connectivity when viewing harm to others.
abstract: The presence of elevated callous unemotional (CU) traits seems to designate a distinct group of children and adolescents with serious conduct problems. However, the extent to which CU traits impact the aversive reaction to harm is still a contentious issue. Here, we examined the effective connectivity seeded in the anterior insula and anterior cingulate cortex in a large number of children (N = 123, age 9-11, 60 females) with various levels of conduct disorder (CD) symptoms in response to visual stimuli depicting other people being physically injured. Perceiving others being harmed was associated with increased hemodynamic activity in the left amygdala and right temporoparietal junction (rTPJ). Children with higher callous traits showed less functional connectivity seeded in anterior cingulate with left amygdala and anterior insula. Conversely, CD symptoms were positively related to connectivity of insula with rTPJ. Overall, these results suggest that callousness is marked by the disruption of widespread cortical networks responsible for detecting and appropriately responding to important environmental cues, such as the distress of others.
authors.affiliation: The Child Neurosuite - Department of Psychology, University of Chicago, Chicago, Illinois.
authors.forename: Keith J
authors.initials: KJ
authors.lastname: Yoder
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Chicago Medicine, Chicago, Illinois.|Department of Public Health Sciences, University of Chicago, Chicago, IL.
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Lahey
authors.affiliation: The Child Neurosuite - Department of Psychology, University of Chicago, Chicago, Illinois.|Department of Psychiatry and Behavioral Neuroscience, University of Chicago Medicine, Chicago, Illinois.
authors.forename: Jean
authors.initials: J
authors.lastname: Decety
mesh_terms: D000679:Amygdala / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D019955:Conduct Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D004644:Emotions; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation; D019655:Quantitative Trait, Heritable
references.citation: Brain Struct Funct. 2010 Jun;214(5-6):535-49
references.pmid: 20512367
references.citation: J Child Psychol Psychiatry. 2008 Apr;49(4):359-75
references.pmid: 18221345
references.citation: J Am Acad Child Adolesc Psychiatry. 2000 Jan;39(1):28-38
references.pmid: 10638065
references.citation: J Clin Child Adolesc Psychol. 2007 Jul-Sep;36(3):334-46
references.pmid: 17658978
references.citation: Neuroimage. 2003 Aug;19(4):1835-42
references.pmid: 12948738
references.citation: Brain. 2016 Jan;139(Pt 1):54-61
references.pmid: 26608745
references.citation: Neuroimage. 2012 Aug 15;62(2):782-90
references.pmid: 21979382
references.citation: Dev Psychopathol. 2008 Fall;20(4):1081-102
references.pmid: 18838032
references.citation: J Neurophysiol. 2012 Dec;108(11):3068-72
references.pmid: 22956794
references.citation: Biol Psychol. 2009 Feb;80(2):203-11
references.pmid: 18940230
references.citation: Neuroimage. 2009 Oct 15;48(1):63-72
references.pmid: 19573611
references.citation: Hum Brain Mapp. 2015 Oct;36(10):4202-9
references.pmid: 26219745
references.citation: Dev Psychopathol. 2012 May;24(2):623-36
references.pmid: 22559135
references.citation: Neuropsychologia. 2011 Sep;49(11):2994-3001
references.pmid: 21762712
references.citation: J Child Psychol Psychiatry. 2013 Aug;54(8):900-10
references.pmid: 23488588
references.citation: J Psychiatr Res. 2004 Jan;38(1):17-25
references.pmid: 14690767
references.citation: Sci Rep. 2014 Jun 19;4:5354
references.pmid: 24942045
references.citation: J Neurophysiol. 2010 Aug;104(2):584-6
references.pmid: 20554847
references.citation: J Neurosci. 2014 Mar 19;34(12):4161-6
references.pmid: 24647937
references.citation: Neuroscientist. 2007 Dec;13(6):580-93
references.pmid: 17911216
references.citation: J Neurosci. 2007 Feb 28;27(9):2349-56
references.pmid: 17329432
references.citation: Arch Gen Psychiatry. 2010 Apr;67(4):406-13
references.pmid: 20368516
references.citation: J Child Psychol Psychiatry. 2016 Apr;57(4):510-9
references.pmid: 26472591
references.citation: Neuroimage. 2010 May 1;50(4):1676-82
references.pmid: 20080194
references.citation: Biol Psychiatry. 2005 Jan 1;57(1):7-15
references.pmid: 15607294
references.citation: PLoS One. 2010 Sep 14;5(9):e12157
references.pmid: 20856853
references.citation: Front Hum Neurosci. 2013 Sep 24;7:489
references.pmid: 24093010
references.citation: Brain. 2013 Jun;136(Pt 6):1929-41
references.pmid: 23576128
references.citation: J Abnorm Psychol. 2007 Feb;116(1):155-65
references.pmid: 17324026
references.citation: Brain Struct Funct. 2012 Oct;217(4):783-96
references.pmid: 22270812
references.citation: Pain. 2004 Jan;107(1-2):5-6
references.pmid: 14715382
references.citation: Psychol Bull. 2014 Jan;140(1):1-57
references.pmid: 23796269
references.citation: Assessment. 2006 Dec;13(4):454-69
references.pmid: 17050915
references.citation: Acta Paediatr. 2014 Jan;103(1):70-80
references.pmid: 24117532
references.citation: Psychol Rev. 2012 Oct;119(4):789-806
references.pmid: 22800411
references.citation: Child Dev. 2013 Jan-Feb;84(1):154-62
references.pmid: 22974268
references.citation: J Abnorm Child Psychol. 2005 Aug;33(4):471-87
references.pmid: 16118993
references.citation: JAMA Psychiatry. 2013 Jun;70(6):638-45
references.pmid: 23615636
references.citation: Trends Cogn Sci. 2012 Jan;16(1):52-60
references.pmid: 22177031
references.citation: Dev Psychopathol. 2008 Summer;20(3):941-73
references.pmid: 18606039
references.citation: Arch Gen Psychiatry. 2012 Aug;69(8):814-22
references.pmid: 22868935
references.citation: World Psychiatry. 2007 Jun;6(2):84-91
references.pmid: 18235858
references.citation: Neuroimage. 2011 Feb 1;54(3):2492-502
references.pmid: 20946964
references.citation: J Am Acad Child Adolesc Psychiatry. 2001 Apr;40(4):443-9
references.pmid: 11314570
references.citation: Pain. 2009 May;143(1-2):71-5
references.pmid: 19254825
references.citation: Arch Gen Psychiatry. 2012 Mar;69(3):283-92
references.pmid: 22393220
references.citation: Cereb Cortex. 2012 Jan;22(1):209-20
references.pmid: 21616985
references.citation: Front Hum Neurosci. 2012 Aug 27;6:246
references.pmid: 22969714
references.citation: Transl Psychiatry. 2015 Aug 25;5:e625
references.pmid: 26305476
references.citation: Psychol Sci Public Interest. 2011 Dec;12(3):95-162
references.pmid: 26167886
references.citation: Nat Rev Neurosci. 2002 Aug;3(8):655-66
references.pmid: 12154366
references.citation: Curr Biol. 2013 May 20;23(10):901-5
references.pmid: 23643836
references.citation: Nat Rev Neurosci. 2011 Mar;12(3):154-67
references.pmid: 21331082
references.citation: Hum Brain Mapp. 2015 Apr;36(4):1417-28
references.pmid: 25557777
references.citation: Soc Neurosci. 2007;2(3-4):276-91
references.pmid: 18633819
references.citation: J Pers. 2015 Dec;83(6):723-37
references.pmid: 25041571