title: Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats.
abstract: Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; The School of Electronic Information Engineering, Yangtze Normal University, Chongqing, Fuling, 408100 People's Republic of China.
authors.forename: Yingshou
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jing
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.
authors.forename: Yunxiang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.
authors.forename: Yanran
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.
authors.forename: Daqing
authors.initials: D
authors.lastname: Guo
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
keywords: Cognitive damage; Morris water maze; Mozart music; Status epilepticus
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