title: Novel antiviral effect of lithium chloride on mammalian orthoreoviruses in vitro.
abstract: Reovirus not only causes considerable economic loss in the swine industry of the United States and other countries, but also threatens the public health due to its zoonotic potential. According to previous reports, LiCl has antiviral activity against a number of viruses. The inhibitory effects of LiCl on reovirus life cycle in Vero cells were evaluated. The unpaired t-test and one-way ANOVA were used to analyze the differences between experimental groups. We first found that LiCl treatment significantly inhibited reovirus replication in a dose-dependent manner. Furthermore, we found that this antiviral activity of LiCl targets the early stage of viral replication. LiCl could be a potential drug against reovirus infection.
authors.affiliation: National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Nephrology, 1st Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: house.triangle@gmail.com.
authors.forename: Deyang
authors.initials: D
authors.lastname: Kong
authors.affiliation: National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
authors.forename: Gengyuan
authors.initials: G
authors.lastname: Cai
authors.affiliation: National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
authors.forename: Yiren
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Shi
authors.affiliation: National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
authors.forename: Huaqin
authors.initials: H
authors.lastname: Li
authors.affiliation: National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China. Electronic address: betty@scau.edu.cn.
authors.forename: Chong
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002522:Chlorocebus aethiops; D006801:Humans; D018021:Lithium Chloride / Q000494:pharmacology*; D030102:Orthoreovirus, Mammalian / Q000187:drug effects* / Q000502:physiology; D012088:Reoviridae Infections / Q000821:virology; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D018021:Lithium Chloride
keywords: Antiviral effect; LiCl; Reovirus; Replication