title: Unique features of a global human ectoparasite identified through sequencing of the bed bug genome.
abstract: The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host-symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human-bed bug and symbiont-bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.
authors.affiliation: Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
authors.forename: Joshua B
authors.initials: JB
authors.lastname: Benoit
authors.affiliation: Fralin Life Science Institute and Department of Entomology, Virginia Tech, Blacksburg, Virginia 24061, USA.
authors.forename: Zach N
authors.initials: ZN
authors.lastname: Adelman
authors.affiliation: Department of Biology, Applied Zoology, Technische Universitaet Dresden, Dresden 01062, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Reinhardt
authors.affiliation: Department of Biology, University of Rochester, Rochester, New York 14627, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Dolan
authors.affiliation: National Agricultural Library, Beltsville, Maryland 20705, USA.
authors.forename: Monica
authors.initials: M
authors.lastname: Poelchau
authors.affiliation: Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Jennings
authors.affiliation: Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
authors.forename: Elise M
authors.initials: EM
authors.lastname: Szuter
authors.affiliation: Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Hagan
authors.affiliation: Department of Entomology, University of Kentucky, Lexington, Kentucky 40546, USA.
authors.forename: Hemant
authors.initials: H
authors.lastname: Gujar
authors.affiliation: Department of Entomology, University of Kentucky, Lexington, Kentucky 40546, USA.
authors.forename: Jayendra Nath
authors.initials: JN
authors.lastname: Shukla
authors.affiliation: Department of Entomology, University of Kentucky, Lexington, Kentucky 40546, USA.|Department of Entomology, Washington State University, Pullman, Washington 99164, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhu
authors.affiliation: ICAR-National Bureau of Agricultural Insect Resources, Indian Council of Agricultural Research, Bengaluru 560024, India.
authors.forename: M
authors.initials: M
authors.lastname: Mohan
authors.affiliation: Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Nelson
authors.affiliation: Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Rosendale
authors.affiliation: Cologne Biocenter and Zoological Institute, University of Cologne, Cologne 50674, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Derst
authors.affiliation: Institut für Bienenkunde (Polytechnische Gesellschaft), Goethe University Frankfurt, Oberursel 61440, Germany.
authors.forename: Valentina
authors.initials: V
authors.lastname: Resnik
authors.affiliation: Institut für Bienenkunde (Polytechnische Gesellschaft), Goethe University Frankfurt, Oberursel 61440, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wernig
authors.affiliation: Department of Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg 97074, Germany.
authors.forename: Pamela
authors.initials: P
authors.lastname: Menegazzi
authors.affiliation: Department of Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg 97074, Germany.
authors.forename: Christian
authors.identifier: http://orcid.org/0000-0003-4481-3567
authors.initials: C
authors.lastname: Wegener
authors.affiliation: Department of Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg 97074, Germany.
authors.forename: Nicolai
authors.initials: N
authors.lastname: Peschel
authors.affiliation: Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Hendershot
authors.affiliation: Cologne Biocenter and Zoological Institute, University of Cologne, Cologne 50674, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Blenau
authors.affiliation: Cologne Biocenter and Zoological Institute, University of Cologne, Cologne 50674, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Predel
authors.affiliation: Department of Evolutionary Biology, Institute of Biology, Freie Universitaet, Berlin 14195, Germany.
authors.forename: Paul R
authors.identifier: http://orcid.org/0000-0002-8651-4488
authors.initials: PR
authors.lastname: Johnston
authors.affiliation: Department of Genetic Medicine and Development and Swiss Institute of Bioinformatics, University of Geneva, Geneva 1211, Switzerland.
authors.forename: Panagiotis
authors.identifier: http://orcid.org/0000-0003-0939-6745
authors.initials: P
authors.lastname: Ioannidis
authors.affiliation: Department of Genetic Medicine and Development and Swiss Institute of Bioinformatics, University of Geneva, Geneva 1211, Switzerland.|Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology and The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA.
authors.forename: Robert M
authors.identifier: http://orcid.org/0000-0003-4199-9052
authors.initials: RM
authors.lastname: Waterhouse
authors.affiliation: Pest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Nauen
authors.affiliation: Pest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, Germany.
authors.forename: Corinna
authors.initials: C
authors.lastname: Schorn
authors.affiliation: Pest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, Germany.
authors.forename: Mark-Christoph
authors.initials: MC
authors.lastname: Ott
authors.affiliation: Pest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Maiwald
authors.affiliation: Department of Entomology, Texas A&M University, College Station, Texas 77843, USA.
authors.forename: J Spencer
authors.initials: JS
authors.lastname: Johnston
authors.affiliation: Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Ameya D
authors.initials: AD
authors.lastname: Gondhalekar
authors.affiliation: Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Scharf
authors.affiliation: Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Brittany F
authors.initials: BF
authors.lastname: Peterson
authors.affiliation: Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Kapil R
authors.initials: KR
authors.lastname: Raje
authors.affiliation: Department of Entomology and Nematology, University of Florida, Gainesville, Florida 32611, USA.
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Hottel
authors.affiliation: Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
authors.forename: David
authors.initials: D
authors.lastname: Armisén
authors.affiliation: Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
authors.forename: Antonin Jean Johan
authors.initials: AJJ
authors.lastname: Crumière
authors.affiliation: Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
authors.forename: Peter Nagui
authors.initials: PN
authors.lastname: Refki
authors.affiliation: Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
authors.forename: Maria Emilia
authors.initials: ME
authors.lastname: Santos
authors.affiliation: Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
authors.forename: Essia
authors.initials: E
authors.lastname: Sghaier
authors.affiliation: Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
authors.forename: Sèverine
authors.initials: S
authors.lastname: Viala
authors.affiliation: Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
authors.forename: Abderrahman
authors.initials: A
authors.lastname: Khila
authors.affiliation: Department of Entomology, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.
authors.forename: Seung-Joon
authors.initials: SJ
authors.lastname: Ahn
authors.affiliation: National Agricultural Library, Beltsville, Maryland 20705, USA.
authors.forename: Christopher
authors.identifier: http://orcid.org/0000-0002-1253-5550
authors.initials: C
authors.lastname: Childers
authors.affiliation: National Agricultural Library, Beltsville, Maryland 20705, USA.|Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Chien-Yueh
authors.initials: CY
authors.lastname: Lee
authors.affiliation: National Agricultural Library, Beltsville, Maryland 20705, USA.|Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Han
authors.identifier: http://orcid.org/0000-0002-3446-5098
authors.initials: H
authors.lastname: Lin
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Daniel S T
authors.initials: DST
authors.lastname: Hughes
authors.affiliation: Department of Biochemistry and Genetics Otago, University of Otago, Dunedin 9054, New Zealand.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Duncan
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Shwetha C
authors.initials: SC
authors.lastname: Murali
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Qu
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Shannon
authors.initials: S
authors.lastname: Dugan
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Lee
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Hsu
authors.initials: H
authors.lastname: Chao
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Huyen
authors.initials: H
authors.lastname: Dinh
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Han
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Harshavardhan
authors.initials: H
authors.lastname: Doddapaneni
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Kim C
authors.initials: KC
authors.lastname: Worley
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Donna M
authors.initials: DM
authors.lastname: Muzny
authors.affiliation: Institute of Fundamental Science, Massey University, Palmerston North 4442, New Zealand.
authors.forename: David
authors.initials: D
authors.lastname: Wheeler
authors.affiliation: Institute for Developmental Biology, University of Cologne, Cologne 50674, Germany.
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Panfilio
authors.affiliation: Institute for Developmental Biology, University of Cologne, Cologne 50674, Germany.
authors.forename: Iris M
authors.initials: IM
authors.lastname: Vargas Jentzsch
authors.affiliation: Department of Entomology, Texas A&M University, College Station, Texas 77843, USA.
authors.forename: Edward L
authors.initials: EL
authors.lastname: Vargo
authors.affiliation: Department of Biological Sciences, University of Tulsa, Tulsa, Oklahoma 74104, USA.
authors.forename: Warren
authors.identifier: http://orcid.org/0000-0003-2355-0702
authors.initials: W
authors.lastname: Booth
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA.
authors.forename: Markus
authors.initials: M
authors.lastname: Friedrich
authors.affiliation: Center for Autoimmune Genomics and Etiology, Division of Biomedical Informatics, and Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Weirauch
authors.affiliation: Fralin Life Science Institute and Department of Entomology, Virginia Tech, Blacksburg, Virginia 24061, USA.
authors.forename: Michelle A E
authors.initials: MAE
authors.lastname: Anderson
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA.
authors.forename: Jeffery W
authors.initials: JW
authors.lastname: Jones
authors.affiliation: Department of Entomology, The Ohio State University, Wooster, Ohio 44691, USA.
authors.forename: Omprakash
authors.initials: O
authors.lastname: Mittapalli
authors.affiliation: Department of Entomology, The Ohio State University, Wooster, Ohio 44691, USA.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Biological Chemistry and Crop Protection, Rothamsted Research, BBSRC Harpenden, Herts AL5 2JQ, UK.
authors.forename: Jing-Jiang
authors.initials: JJ
authors.lastname: Zhou
authors.affiliation: United States Department of Agriculture-Agricultural Research Service Bee Research Laboratory, Beltsville, Maryland 20705, USA.
authors.forename: Jay D
authors.identifier: http://orcid.org/0000-0002-0036-4651
authors.initials: JD
authors.lastname: Evans
authors.affiliation: Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut 06520, USA.
authors.forename: Geoffrey M
authors.initials: GM
authors.lastname: Attardo
authors.affiliation: Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
authors.forename: Hugh M
authors.initials: HM
authors.lastname: Robertson
authors.affiliation: Department of Genetic Medicine and Development and Swiss Institute of Bioinformatics, University of Geneva, Geneva 1211, Switzerland.
authors.forename: Evgeny M
authors.initials: EM
authors.lastname: Zdobnov
authors.affiliation: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, Bethesda, Maryland 20892, USA.
authors.forename: Jose M C
authors.initials: JMC
authors.lastname: Ribeiro
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Gibbs
authors.affiliation: Department of Biology, University of Rochester, Rochester, New York 14627, USA.
authors.forename: John H
authors.initials: JH
authors.lastname: Werren
authors.affiliation: Department of Entomology, University of Kentucky, Lexington, Kentucky 40546, USA.
authors.forename: Subba R
authors.initials: SR
authors.lastname: Palli
authors.affiliation: Department of Entomology and W.M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA.
authors.forename: Coby
authors.initials: C
authors.lastname: Schal
authors.affiliation: Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Richards
mesh_terms: D000818:Animals; D001511:Bedbugs / Q000235:genetics*; D004478:Ectoparasitic Infestations; D005247:Feeding Behavior; D022761:Gene Transfer, Horizontal / Q000235:genetics*; D016678:Genome; D006790:Host-Parasite Interactions / Q000235:genetics*; D006801:Humans; D007305:Insecticide Resistance / Q000235:genetics*; D007306:Insecticides; D017422:Sequence Analysis, DNA
chemical_list: D007306:Insecticides
references.citation: Annu Rev Entomol. 2007;52:351-74
references.pmid: 16968204
references.citation: Crit Care Med. 2004 Nov;32(11):2293-9
references.pmid: 15640644
references.citation: Biochem Soc Trans. 2006 Dec;34(Pt 6):1252-5
references.pmid: 17073796
references.citation: Genome Biol. 2015;16:83
references.pmid: 25908406
references.citation: Peptides. 2010 Mar;31(3):408-11
references.pmid: 19778561
references.citation: Parasitol Res. 2011 Nov;109(5):1461-4
references.pmid: 21626157
references.citation: Science. 2014 Apr 25;344(6182):380-6
references.pmid: 24763584
references.citation: Arch Insect Biochem Physiol. 2010 Apr;73(4):245-57
references.pmid: 20301216
references.citation: Insect Biochem Mol Biol. 2014 Feb;45:89-110
references.pmid: 24291285
references.citation: PLoS One. 2013;8(4):e61465
references.pmid: 23585900
references.citation: Ecol Evol. 2015 Jan;5(2):409-18
references.pmid: 25691967
references.citation: Insect Mol Biol. 2010 Feb;19 Suppl 1:59-73
references.pmid: 20167018
references.citation: PLoS Negl Trop Dis. 2014 Apr;8(4):e2663
references.pmid: 24763191
references.citation: BMC Genomics. 2012;13:6
references.pmid: 22226239
references.citation: Am J Trop Med Hyg. 2015 Feb;92(2):331-5
references.pmid: 25404068
references.citation: Nucleic Acids Res. 2013 Jan;41(Database issue):D358-65
references.pmid: 23180791
references.citation: Clin Infect Dis. 2011 Jan 15;52(2):200-10
references.pmid: 21288844
references.citation: Neuron. 2014 Mar 5;81(5):984-1000
references.pmid: 24607224
references.citation: Sci Rep. 2013;3:1456
references.pmid: 23492626
references.citation: PLoS Biol. 2010 Feb;8(2):e1000313
references.pmid: 20186266
references.citation: Bioinformatics. 2015 Oct 1;31(19):3210-2
references.pmid: 26059717
references.citation: Front Zool. 2007 Dec 21;4:24
references.pmid: 18154648
references.citation: PLoS One. 2012;7(2):e31037
references.pmid: 22347424
references.citation: Annu Rev Entomol. 2014;59:245-61
references.pmid: 24160423
references.citation: Science. 2007 Sep 21;317(5845):1753-6
references.pmid: 17761848
references.citation: Insect Biochem Mol Biol. 2007 Aug;37(8):754-60
references.pmid: 17628275
references.citation: J Med Entomol. 2007 Mar;44(2):175-8
references.pmid: 17427684
references.citation: Am J Trop Med Hyg. 2007 May;76(5):987-93
references.pmid: 17488928
references.citation: Pest Manag Sci. 2009 Mar;65(3):332-8
references.pmid: 19097027
references.citation: Mol Ecol. 2015 Mar;24(5):980-92
references.pmid: 25611460
references.citation: Insect Biochem Mol Biol. 2013 Sep;43(9):888-97
references.pmid: 23459169
references.citation: Insect Biochem Mol Biol. 2008 Dec;38(12):1138-46
references.pmid: 19280704
references.citation: PLoS One. 2013;8(3):e59262
references.pmid: 23533610
references.citation: J Insect Physiol. 2003 Jan;49(1):11-24
references.pmid: 12770012
references.citation: J Med Entomol. 2009 Jan;46(1):51-7
references.pmid: 19198517
references.citation: PLoS Negl Trop Dis. 2014;8(1):e2594
references.pmid: 24416461
references.citation: Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12168-73
references.pmid: 20566863
references.citation: Proc Biol Sci. 2003 Nov 22;270(1531):2371-5
references.pmid: 14667353
references.citation: Clin Microbiol Rev. 2012 Jan;25(1):164-92
references.pmid: 22232375
references.citation: Nature. 2000 Mar 30;404(6777):456-7
references.pmid: 10761904
references.citation: Nat Rev Microbiol. 2008 Oct;6(10):741-51
references.pmid: 18794912
references.citation: J R Soc Interface. 2015 Mar 6;12(104):20141107
references.pmid: 25673297
references.citation: Ann N Y Acad Sci. 2009 Apr;1163:501-3
references.pmid: 19456399
references.citation: J Comp Physiol B. 2014 Oct;184(7):811-25
references.pmid: 24942313
references.citation: Annu Rev Entomol. 2013;58:373-91
references.pmid: 23020622
references.citation: Appl Environ Microbiol. 2007 Nov;73(22):7199-209
references.pmid: 17890333
references.citation: Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10257-62
references.pmid: 24982177
references.citation: PLoS One. 2015;10(3):e0118855
references.pmid: 25748041
references.citation: Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):769-74
references.pmid: 20080750
references.citation: Cell. 2009 Oct 2;139(1):45-59
references.pmid: 19804753
references.citation: J Med Entomol. 2008 Nov;45(6):1092-101
references.pmid: 19058634
references.citation: PLoS Pathog. 2013 Aug;9(8):e1003462
references.pmid: 23966852
references.citation: Microbiology. 2004 Mar;150(Pt 3):522-5
references.pmid: 14993300
references.citation: PLoS One. 2011;6(10):e26228
references.pmid: 22039447
references.citation: Nat Commun. 2014;5:3636
references.pmid: 24845553
references.citation: J Exp Biol. 2014 Feb 15;217(Pt 4):552-7
references.pmid: 24198260
references.citation: BMC Genomics. 2008;9:22
references.pmid: 18205929
references.citation: BMC Biol. 2008;6:27
references.pmid: 18577218
references.citation: Science. 2006 Jun 23;312(5781):1809-12
references.pmid: 16794082
references.citation: Mem Inst Oswaldo Cruz. 2012 Jun;107(4):437-49
references.pmid: 22666852
references.citation: Mol Biol Evol. 2004 Jun;21(6):1081-4
references.pmid: 15014143
references.citation: J Exp Biol. 1995 Jul;198(Pt 7):1519-26
references.pmid: 7658188
references.citation: J Proteome Res. 2010 Aug 6;9(8):3820-31
references.pmid: 20441151