title: In vitro degradation behavior of Fe-20 Mn-1.2C alloy in three different pseudo-physiological solutions.
abstract: High manganese austenitic steels such as Fe-20Mn-1.2C alloys are among the most promising candidates for biodegradable stents applications due to their high strength, high ductility and their chemical composition. In the current work, 14 day static in-vitro tests were performed in controlled atmosphere to assess the degradation behavior in three common pseudo-physiological solutions, i.e. commercial Hanks' (CH), modified Hanks' (MH) and albumin-enriched Dulbecco's modified phosphate buffered saline (DPBS) solutions. The degraded samples surfaces as well as the degradation products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Degradation of material and degradation products are shown to be strongly dependent on the test medium due to the presence of different ionic species such as HCO3(-), CO3(2-), Cl(-), Ca(2+) or phosphate groups. In both MH and CH solutions, the increased content of HCO3(-) ions seems to promote MnCO3 crystal growth on sample surfaces whereas the presence of albumin and high content of phosphate ions promotes the formation of an amorphous layer rich in phosphates, iron and manganese.
authors.affiliation: Laboratory for Biomaterials and Bioengineering, Canada Research Chair Tier I in Biomaterials and Bioengineering for the Innovation in Surgery, Department of Mining, Metallurgy and Materials Engineering, CHU de Quebec Research Center, Laval University, Canada; Department of Mining, Metallurgy and Materials Engineering, Laval University, Canada.
authors.forename: Essowè
authors.initials: E
authors.lastname: Mouzou
authors.affiliation: Laboratory for Biomaterials and Bioengineering, Canada Research Chair Tier I in Biomaterials and Bioengineering for the Innovation in Surgery, Department of Mining, Metallurgy and Materials Engineering, CHU de Quebec Research Center, Laval University, Canada.
authors.forename: Carlo
authors.initials: C
authors.lastname: Paternoster
authors.affiliation: Laboratory for Biomaterials and Bioengineering, Canada Research Chair Tier I in Biomaterials and Bioengineering for the Innovation in Surgery, Department of Mining, Metallurgy and Materials Engineering, CHU de Quebec Research Center, Laval University, Canada.
authors.forename: Ranna
authors.initials: R
authors.lastname: Tolouei
authors.affiliation: Laboratory for Biomaterials and Bioengineering, Canada Research Chair Tier I in Biomaterials and Bioengineering for the Innovation in Surgery, Department of Mining, Metallurgy and Materials Engineering, CHU de Quebec Research Center, Laval University, Canada; Department of Mining, Metallurgy and Materials Engineering, Laval University, Canada.
authors.forename: Agung
authors.initials: A
authors.lastname: Purnama
authors.affiliation: Laboratory for Biomaterials and Bioengineering, Canada Research Chair Tier I in Biomaterials and Bioengineering for the Innovation in Surgery, Department of Mining, Metallurgy and Materials Engineering, CHU de Quebec Research Center, Laval University, Canada.
authors.forename: Pascale
authors.initials: P
authors.lastname: Chevallier
authors.affiliation: Department of Mining, Metallurgy and Materials Engineering, Laval University, Canada.
authors.forename: Dominique
authors.initials: D
authors.lastname: Dubé
authors.affiliation: PSL Research University, Chimie Paris Tech-CNRS, Institut de Recherche de Chimie Paris, 75005 Paris, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Prima
authors.affiliation: Laboratory for Biomaterials and Bioengineering, Canada Research Chair Tier I in Biomaterials and Bioengineering for the Innovation in Surgery, Department of Mining, Metallurgy and Materials Engineering, CHU de Quebec Research Center, Laval University, Canada; Department of Mining, Metallurgy and Materials Engineering, Laval University, Canada. Electronic address: Diego.Mantovani@gmn.ulaval.ca.
authors.forename: Diego
authors.initials: D
authors.lastname: Mantovani
mesh_terms: D000497:Alloys / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*
chemical_list: D000497:Alloys; D008345:Manganese; D007501:Iron
keywords: Cardio-vascular applications; Corrosion; Degradable metals; Degradation; Medical devices; Metals; New alloys