title: Enterococcal bloodstream infection. Design and validation of a mortality prediction rule.
abstract: BACKGROUND
  To develop a prediction rule to describe the risk of death as a result of enterococcal bloodstream infection.
  
  
  METHODS
  A prediction rule was developed by analysing data collected from 122 patients diagnosed with enterococcal BSI admitted to the Clínica Universidad de Navarra (Pamplona, Spain); and validated by confirming its accuracy with the data of an external population (Hospital del Mar, Barcelona).
  
  
  RESULTS
  According to this model, independent significant predictors for the risk of death were being diabetic, have received appropriate treatment, severe prognosis of the underlying diseases, have renal failure, received solid organ transplant, malignancy, source of the bloodstream infection and be immunosuppressed. The prediction rule showed a very good calibration (Hosmer-Lemeshow statistic, P = 0.93) and discrimination for both training and testing sets (area under ROC curve = 0.84 and 0.83 respectively).
  
  
  CONCLUSIONS
  The predictive rule was able to predict risk of death as a result of enterococcal bloodstream infection as well as to identify patients, who being below the threshold value, will have a low risk of death with a negative predictive value of 96%.
authors.affiliation: Department of Clinical Microbiology, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Pérez-García
authors.affiliation: Internal Medicine, Division of Intermediate Care and Hospitalists Unit, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: M F
authors.initials: MF
authors.lastname: Landecho
authors.affiliation: Interdusciplinar Education, Universidad Europea, Pamplona, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Beunza
authors.affiliation: Service of Pharmacy, Hospital Universitari del Mar, Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Conde-Estévez
authors.affiliation: Service of Infectious diseases, Hospital Universitari del Mar, Institut Hospital del Mar d'Investigacions Médiques, CEXS-Universitat Pompeu Fabra, CIBERES, Barcelona, Spain.
authors.forename: J P
authors.initials: JP
authors.lastname: Horcajada
authors.affiliation: Service of Pharmacy, Hospital Universitari del Mar, Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Grau
authors.affiliation: Department of Preventive Medicine and Public Health, Universidad de Navarra, Pamplona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gea
authors.affiliation: Internal Medicine, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Mauleón
authors.affiliation: Service of Infectious diseases, Hospital Universitari del Mar, Institut Hospital del Mar d'Investigacions Médiques, CEXS-Universitat Pompeu Fabra, CIBERES, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Sorli
authors.affiliation: Depatament of Microbiology, Laboratori de Referencia de Catalunya, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Gómez
authors.affiliation: Service of Evaluation and Clinical Epidemiology, Hospital Universitari del Mar, Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Terradas
authors.affiliation: Internal Medicine, Division of Intermediate Care and Hospitalists Unit, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Lucena
authors.affiliation: Internal Medicine, Division of Intermediate Care and Hospitalists Unit, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Alegre
authors.affiliation: Internal Medicine, Division of Intermediate Care and Hospitalists Unit, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Huerta
authors.affiliation: Division of Infectious diseases, Department Clinical Microbiology, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Del Pozo
mesh_terms: D000368:Aged; D016470:Bacteremia / Q000382:microbiology* / Q000401:mortality*; D015897:Comorbidity; D003661:Decision Support Techniques; D016983:Enterococcus / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013030:Spain