title: Innate lymphoid cells and the MHC.
abstract: Innate lymphoid cells (ILCs) are a new class of immune cells that include natural killer (NK) cells and appear to be the innate counterparts to CD4(+) helper T cells and CD8(+) cytotoxic T cells based on developmental and functional similarities. Like T cells, both NK cells and other ILCs also show connections to the major histocompatibility complex (MHC). In human and mouse, NK cells recognize and respond to classical and nonclassical MHC I molecules as well as structural homologues, whereas mouse ILCs have recently been shown to express MHC II. We describe the history of MHC I recognition by NK cells and discuss emerging roles for MHC II expression by ILC subsets, making comparisons between both mouse and human when possible.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Robinette
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: M
authors.initials: M
authors.lastname: Colonna
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D006801:Humans; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology; D008285:Major Histocompatibility Complex; D051379:Mice; D055630:Receptors, NK Cell Lectin-Like / Q000235:genetics / Q000276:immunology*; D013045:Species Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology
chemical_list: D015703:Antigens, CD; D016207:Cytokines; D055630:Receptors, NK Cell Lectin-Like
keywords: Innate lymphoid cells; MHC; cytokines; human; human leukocyte antigen; innate; mouse
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