title: In vitro activity of antimicrobial agents against streptococcus pyogenes isolated from different regions of Khyber Pakhtun Khwa Pakistan.
abstract: The present study investigates the antibiotic resistance of S. pyogenes of 600 isolates collected from different body parts including throat and sputum were analyzed for their antimicrobial susceptibility to 5 antibiotics using the Kirby Bauer disc diffusion method. Based on different identification tests including, gram staining, beta hemolysis, catalase test and bacitracin sensitivity test, a total of 138 isolates were confirmed as S. pyogenes. The prevalence of S. pyogenes was 80% in sore throat and 29% in sputum samples. These isolates were further tested for antibiotics resistance using disk diffusion method. Out of 138 isolates, 49.27% isolates showed resistance towards cefixime, 28.98% towards cefotaxime and 17.39% towards ciprofloxacin, 17.39% towards ampicillin, 17.39% towards erythromycin, 15.94% towards streptomycin, 0.724% isolates towards chloromphenicol and 0% towards penicillin. Among the resistant isolates of S. pyogenes, 60.71% showed resistance towards cefixime, 57.14% towards ciprofloxacin, 57.14% towards streptomycin, 50% towards erythromycin and 25% towards cefotaxime.
authors.affiliation: Centre of Biotechnology and Microbiology, University of Peshawar, KPK, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Rizwan
authors.affiliation: Institute of Biotechnology and Genetic Engineering, University of Agriculture, Peshawar, KPK, Pakistan.
authors.forename: Jehan
authors.initials: J
authors.lastname: Bakht
authors.affiliation: Centre of Biotechnology and Microbiology, University of Peshawar, KPK, Pakistan.
authors.forename: Nafees
authors.initials: N
authors.lastname: Bacha
authors.affiliation: Centre of Biotechnology and Microbiology, University of Peshawar, KPK, Pakistan.
authors.forename: Bashir
authors.initials: B
authors.lastname: Ahmad
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests; D013297:Streptococcus pyogenes / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents