title: A Caenorhabditis elegans Homologue of LYST Functions in Endosome and Lysosome-Related Organelle Biogenesis.
abstract: LYST-1 is a Caenorhabditis elegans BEACH domain containing protein (BDCP) homologous to LYST and NBEAL2, BDCPs controlling organelle biogenesis that are implicated in human disease. Unlike the three other BDCPs encoded by C. elegans, mutations in lyst-1 lead to smaller lysosome-related organelles (LROs), smaller lysosomes, increased numbers of LROs and decreased numbers of early endosomes. lyst-1(-) mutations do not obviously disrupt protein trafficking to lysosomes or LROs, however, the formation of gut granules is diminished.
authors.affiliation: Department of Biology, Lewis & Clark College, 0615 SW Palatine Hill Rd., Portland, OR, 97219, USA.
authors.forename: Alec
authors.initials: A
authors.lastname: Barrett
authors.affiliation: Department of Biology, Lewis & Clark College, 0615 SW Palatine Hill Rd., Portland, OR, 97219, USA.
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Hermann
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C102161:LYST protein, human; D033921:Vesicular Transport Proteins
keywords: BEACH domain; Caenorhabditis elegans; LYST; NBEAL2; lysosome; lysosome-related organelle