title: [Prevalence, severity, characteristics and coronary calcified score of coronary artery plaques are different in women than men with suspected coronary artery disease].
abstract: OBJECTIVE
  To validate the prevalence, severity, characteristics and coronary calcified score(CACS) of coronary artery plaques in women are different from men.
  
  
  METHODS
  A total of 3 752 patients with suspected coronary artery disease in the First Affiliated Hospital of China Medical University were enrolled between September 2011 and December 2013. Patients with suspect CAD underwent 256-detecter coronary computed tomography (CCTA) and CACS measurement were enrolled. The differences of sex-associated coronary artery plaques were assessed. The univariable and multivariable Logistic regression were employ to assess the association female and male with coronary artery plaques.
  
  
  RESULTS
  A total of 3 752 patients including 1 832 females and 1 920 males, the average age of the patients was (56 ± 11) years. Women were older and less smoker than men. The prevalences of any plaque, 2-,3-/LM disease and significant/severe stenosis significantly decreased in female than male (all P<0.01). The proportion of non-calcified plaques significantly higher and mixed plaque significantly lower in female than male (all P<0.01). the proportion of women were significantly lower than men in CACS>0 (all P<0.01). The similar tendency also happened in four age-matched female and male subgroups. After adjustment, female was the significant protective factor for significant and severe stenosis, 2- and 3-/LM vessel disease, calcified and mixed plaques, and CACS>100 (all P<0.01); female was the significant protective factor for non-calcified plaques in the univariate analysis (P<0.01). When the age ≥ 65, female became the significant risk factor for coronary artery plaques (all P<0.01).
  
  
  CONCLUSIONS
  Women have less prevalence and extensive coronary artery plaques and lower CACS, the plaque characteristics in women is more frequently composed by non-calcified plaques than men, even after matched by age. With age, female change from a protective factor to a risk factor for coronary artery plaques.
authors.affiliation: Department of Cardiology, Department of Cardiology of Aging, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Yujiao
authors.initials: Y
authors.lastname: Sun
authors.forename: Guoxian
authors.initials: G
authors.lastname: Qi
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhi
authors.forename: Song
authors.initials: S
authors.lastname: Geng
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Email: dr_wentian@163.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Tian
mesh_terms: D016893:Carotid Stenosis; D002681:China; D003324:Coronary Artery Disease; D005260:Female; D006321:Heart; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D061205:Vascular Calcification