title: Dental materials for cleft palate repair.
abstract: Numerous bone and soft tissue grafting techniques are followed to repair cleft of lip and palate (CLP) defects. In addition to the gold standard surgical interventions involving the use of autogenous grafts, various allogenic and xenogenic graft materials are available for bone regeneration. In an attempt to discover minimally invasive and cost effective treatments for cleft repair, an exceptional growth in synthetic biomedical graft materials have occurred. This study gives an overview of the use of dental materials to repair cleft of lip and palate (CLP). The eligibility criteria for this review were case studies, clinical trials and retrospective studies on the use of various types of dental materials in surgical repair of cleft palate defects. Any data available on the surgical interventions to repair alveolar or palatal cleft, with natural or synthetic graft materials was included in this review. Those datasets with long term clinical follow-up results were referred to as particularly relevant. The results provide encouraging evidence in favor of dental and other related biomedical materials to fill the gaps in clefts of lip and palate. The review presents the various bones and soft tissue replacement strategies currently used, tested or explored for the repair of cleft defects. There was little available data on the use of synthetic materials in cleft repair which was a limitation of this study. In conclusion although clinical trials on the use of synthetic materials are currently underway the uses of autologous implants are the preferred treatment methods to date.
authors.affiliation: Department of Materials Science & Engineering, Kroto Research Institute, University of Sheffield, Broad Lane, Sheffield, UK; Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Lahore, Pakistan. Electronic address: f.sharif@sheffield.ac.uk.
authors.forename: Faiza
authors.initials: F
authors.lastname: Sharif
authors.affiliation: Department of Materials Science & Engineering, Kroto Research Institute, University of Sheffield, Broad Lane, Sheffield, UK.
authors.forename: Ihtesham
authors.initials: I
authors.lastname: Ur Rehman
authors.affiliation: Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Lahore, Pakistan. Electronic address: nawshadmuhammad@ciitlahore.edu.pk.
authors.forename: Nawshad
authors.initials: N
authors.lastname: Muhammad
authors.affiliation: Department of Materials Science & Engineering, Kroto Research Institute, University of Sheffield, Broad Lane, Sheffield, UK.
authors.forename: Sheila
authors.initials: S
authors.lastname: MacNeil
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D001704:Biopolymers / Q000737:chemistry / Q000627:therapeutic use; D018786:Bone Substitutes / Q000627:therapeutic use; D002516:Ceramics / Q000737:chemistry / Q000627:therapeutic use; D002972:Cleft Palate / Q000601:surgery / Q000628:therapy*; D003764:Dental Materials / Q000627:therapeutic use*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology
chemical_list: D001672:Biocompatible Materials; D001704:Biopolymers; D018786:Bone Substitutes; D003764:Dental Materials
keywords: Bone substitute; Cleft palate; Craniofacial repair; Dental materials; Synthetic graft