title: Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson's disease.
abstract: Several antecedent studies had reported close relationship between low body weight and Parkinson's disease (PD). However, there have been few investigations about the role of body weight to nigrostriatal dopaminergic neurodegeneration. This study enrolled 398 de novo patients with PD whom underwent [18F] N-(3-Fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scan and body mass index (BMI) measurement. The relationships between BMI and dopamine transporter (DAT) activity were analyzed using linear regression analysis. A multivariate analysis adjusted for age, gender, disease duration, smoking status, coffee and tea consumption, and residence area revealed that BMI remained independently and significantly associated with DAT activity in all striatal subregions. Moreover, multiple logistic regression analyses showed that BMI was a significant predictor for the lowest quartile of DAT activity in the anterior putamen, ventral striatum, caudate nucleus, and total striatum. The present findings suggest that a low BMI might be closely associated with low density of nigrostriatal dopaminergic neurons in PD, which could support the evidence for the role of low body weight to PD-related pathologies.
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jae Jung
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
authors.forename: Jungsu S
authors.initials: JS
authors.lastname: Oh
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jee H
authors.initials: JH
authors.lastname: Ham
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Dong H
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
authors.forename: Injoo
authors.initials: I
authors.lastname: Lee
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Young H
authors.initials: YH
authors.lastname: Sohn
authors.affiliation: Department of Nuclear Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
authors.forename: Jae S
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address: phisland@chol.net.
authors.forename: Phil Hyu
authors.initials: PH
authors.lastname: Lee
mesh_terms: D000368:Aged; D015992:Body Mass Index; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000172:deficiency* / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000209:etiology* / Q000378:metabolism*; D013378:Substantia Nigra / Q000378:metabolism*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D004298:Dopamine
keywords: Body mass index; Dopamine transporter activity; Parkinson's disease