title: Therapeutic microRNA Delivery Strategies with Special Emphasis on Cancer Therapy and Tumorigenesis: Current Trends and Future Challenges.
abstract: BACKGROUND
  Over the decade, miRNAs are the most important molecules for the biopharmaceutical industry due to their relation with several human diseases. Presently, the phase-II clinical trial has been initiated for the first miRNA-based therapeutics ("Miravirsen") to treat HCV infection. It has been expected that many more miRNA-based therapeutics will enter the clinical trials. Therefore, it is important to develop different kinds of novel delivery systems with better efficacy and more efficiency, but fewer side effects.
  
  
  METHODS
  We have undertaken a structured search of bibliographic databases for peer-reviewed research literature to solve our review question. Literature survey was performed widely to write this review article.
  
  
  RESULTS
  In this review, we have discussed the various types of miRNA delivery systems such as viral vectors, lipid-based systems, nanocarriers, and LNA-customized DNA delivery without any delivery-mediated agent. Current status, technical support, and the future challenges for miRNA-based delivery are also discussed.
  
  
  CONCLUSIONS
  Recent development and understanding of miRNA had shown the therapeutic potentiality of miRNA.
authors.affiliation: Department of Marine Biotechnology and Resources, College of Marine Sciences, and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yatsen University, Kaohisung, Taiwan. drchiranjib@yahoo.com.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Agoramoorthy
authors.affiliation: Department of Marine Biotechnology and Resources, College of Marine Sciences, and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yatsen University, Kaohisung, Taiwan. shinlin@faculty.nsysu.edu.tw.
authors.forename: Chan-Shing
authors.initials: CS
authors.lastname: Lin
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000008:administration & dosage* / Q000627:therapeutic use*; D009369:Neoplasms / Q000235:genetics / Q000628:therapy
chemical_list: D035683:MicroRNAs