title: A new cembrane-type diterpenoid from Bornean liverwort Chandonanthus hirtellus.
abstract: A new compound, chandonanol (1), along with four known compounds, chandonanthone (2), iso-chandonanthone (3), anastreptene (4), and (6R,7S)-sesquiphellandrene (5), was isolated from the MeOH extract of Bornean liverwort Chandonanthus hirtellus. The structure of the new metabolite was established by analyses of the spectroscopic data (1D NMR, 2D NMR, HRESIMS, and IR). These compounds were tested for their activity against antibiotic-resistant clinical strains. Chandonanol (1) exhibited potent bactericidal activity against Staphylococcus aureus and Escherichia coli.
authors.affiliation: a Laboratory of Natural Products Chemistry , Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah , Kota Kinabalu 88400 , Malaysia.
authors.forename: Shean-Yeaw
authors.initials: SY
authors.lastname: Ng
authors.affiliation: a Laboratory of Natural Products Chemistry , Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah , Kota Kinabalu 88400 , Malaysia.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kamada
authors.affiliation: b Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah , Kota Kinabalu 88400 , Malaysia.
authors.forename: Monica
authors.initials: M
authors.lastname: Suleiman
authors.affiliation: a Laboratory of Natural Products Chemistry , Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah , Kota Kinabalu 88400 , Malaysia.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Vairappan
mesh_terms: D001893:Borneo; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D035926:Hepatophyta / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes; C000613228:chandonanol; C037071:cembrane
keywords: Borneo Island; Cembrane; Chandonanthus hirtellus; diterpenoid; liverwort