title: Co-administration of cisplatin and curcumin does not alter mood-associated behaviors.
abstract: OBJECTIVE
  Cisplatin (cis-diamminedichloroplatinum (II)) is a widely-used platinum-based chemotherapeutic agent which has dose-limiting side-effects. Also, the drug resistance is another instance that decreases treatment success in cisplatin chemotherapy. The growing body of evidence suggests that curcumin, a polyphenolic compound extracted from the spice turmeric, may exert synergistic effects and sensitize malign cells to cisplatin, while alleviating cytotoxicity-related side-effects. The present study was aimed to investigate mood-associated interactions between cisplatin and curcumin.
  
  
  METHODS
  Thirty-four adult male Wistar albino rats were randomly assigned to four groups as control, curcumin (300 mg/kg/day, p.o. for 5 weeks), cisplatin (5 mg/kg/week, i.p. for 5 weeks), and curcumin plus cisplatin (same doses as above). The open field, elevated plus maze, and forced swim tests were engaged to evaluate mood-associated behaviors.
  
  
  RESULTS
  We demonstrated that depression- and anxiety-like behaviors were not altered by the administration of curcumin along with the chronic cisplatin treatment.
  
  
  CONCLUSIONS
  According to the results of the present study, we concluded that curcumin might be regarded as a safe adjuvant in cisplatin chemotherapy in terms of the mood-associated behaviors (Fig. 4, Ref. 41).
authors.forename: E A
authors.initials: EA
authors.lastname: Demir
authors.forename: M
authors.initials: M
authors.lastname: Oz
authors.forename: M I
authors.initials: MI
authors.lastname: Alp
authors.forename: H S
authors.initials: HS
authors.lastname: Gergerlioglu
authors.forename: K E
authors.initials: KE
authors.lastname: Nurullahoglu
authors.forename: F H
authors.initials: FH
authors.lastname: Yerlikaya
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D001522:Behavior, Animal / Q000187:drug effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003474:Curcumin / Q000008:administration & dosage / Q000009:adverse effects; D004195:Disease Models, Animal; D004357:Drug Synergism; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000970:Antineoplastic Agents; D003474:Curcumin; D002945:Cisplatin
keywords: anxiety; locomotion; cisplatin; curcumin; depression; exploration.