title: The Chemistry of the Akuammiline Alkaloids.
abstract: An update on the literature covering the akuammiline family of alkaloids is presented. This chapter begins with a summary of new akuammiline alkaloids reported since 2000 and is followed by an overview of new reported bioactivities of akuammiline alkaloids since 2000. The remainder of the chapter comprises a comprehensive review of the synthetic chemistry that has been reported in the last 50 years concerning akuammiline alkaloids and their structural motifs.
authors.affiliation: Merck Research Laboratories, West Point, PA, USA.
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Adams
authors.affiliation: Department of Chemistry, Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, PA, USA; Monell Chemical Senses Center, Philadelphia, PA, USA.
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis / Q000737:chemistry*; D029062:Apocynaceae / Q000737:chemistry*; D002227:Carbazoles / Q000378:metabolism; D014748:Vinca Alkaloids / Q000096:biosynthesis
chemical_list: D000470:Alkaloids; D002227:Carbazoles; D014748:Vinca Alkaloids; C504098:minfiensine; C543267:vincorine
keywords: Akuammiline; Aspidophylline A; Echitamine; Indole alkaloids; Picrinine; Scholarisine A; Total synthesis; Vincorine