title: Pressure topography metrics for high-resolution pharyngeal-esophageal manofluorography-a normative study of younger and older adults.
abstract: We aimed to define normative values for novel pressure topography metrics for high-resolution pharyngeal-esophageal manofluorography. The effects of age, gender, and bolus properties were examined.
  
  
  
  Concurrent high-resolution manometry (HRM) and videofluoroscopy data were collected from 22 younger (aged 21-40) and 22 older (aged 60-80) healthy subjects. Pressure topography was analyzed by correlating pressure domains with videofluoroscopic events. Nine pressure topography metrics of the pharyngeal and proximal esophageal swallow were extracted; four of these were also compared with previously obtained esophageal HRM studies to assess the effects of catheter diameter.
  
  
  
  Older individuals exhibited more vigorous contractility in the pharynx than did younger subjects with all bolus types, but the greatest values for both groups were with effortful swallow and on that measure the age groups were similar. Upper esophageal sphincter (UES) intrabolus pressure during sphincter opening was also greater in the older subjects. Some gender differences were observed, particularly related to proximal esophageal contractile vigor. Bolus consistency had no consistent effect. Studies using the larger catheter diameter resulted in significantly greater contractile vigor in the UES and proximal esophagus.
  
  
  
  Older adults exhibited more vigorous pharyngeal contractions than young adults, albeit within a similar range of capacity, perhaps reflecting a compensatory response to other age-related physiological changes. Greater UES intrabolus pressures observed during bolus transit in the older group likely reflect reduced UES compliance with age. Normative data on novel HRM metrics collected in this study can serve as a reference for future clinical studies.
authors.affiliation: Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA.
authors.forename: N
authors.initials: N
authors.lastname: Nativ-Zeltzer
authors.affiliation: Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Logemann
authors.affiliation: Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA.
authors.forename: S G
authors.initials: SG
authors.lastname: Zecker
authors.affiliation: Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Kahrilas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003679:Deglutition / Q000502:physiology*; D004947:Esophagus / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D005471:Fluoroscopy / Q000379:methods; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods*; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology*; D010614:Pharynx / Q000000981:diagnostic imaging / Q000502:physiology*; D011312:Pressure; D014741:Video Recording / Q000379:methods; D055815:Young Adult
keywords: dysphagia; high-resolution manometry; mano-fluorography; pharyngeal swallow; upper esophageal sphincter
references.citation: Laryngoscope. 2000 Mar;110(3 Pt 1):434-9
references.pmid: 10718434
references.citation: Otolaryngol Head Neck Surg. 2013 Jul;149(1):126-33
references.pmid: 23728150
references.citation: World J Gastroenterol. 2009 Jan 14;15(2):131-8
references.pmid: 19132761
references.citation: Gastroenterology. 1992 Sep;103(3):823-9
references.pmid: 1499933
references.citation: Dysphagia. 2004 Summer;19(3):182-91
references.pmid: 15383948
references.citation: Head Neck. 2003 Jun;25(6):432-7
references.pmid: 12784234
references.citation: Dysphagia. 2013 Jun;28(2):146-52
references.pmid: 22986957
references.citation: Am J Physiol Gastrointest Liver Physiol. 2006 Sep;291(3):G525-31
references.pmid: 16645162
references.citation: Dysphagia. 2014 Oct;29(5):564-70
references.pmid: 24969727
references.citation: J Speech Lang Hear Res. 2009 Feb;52(1):240-53
references.pmid: 19064903
references.citation: Dysphagia. 2014 Feb;29(1):2-16
references.pmid: 24233810
references.citation: J Thorac Cardiovasc Surg. 1988 Feb;95(2):281-5
references.pmid: 3339894
references.citation: Am J Physiol. 1997 May;272(5 Pt 1):G1057-63
references.pmid: 9176214
references.citation: Dysphagia. 2006 Oct;21(4):270-4
references.pmid: 17216388
references.citation: Neurogastroenterol Motil. 2013 Dec;25(12):e821-9
references.pmid: 23941282
references.citation: Neurogastroenterol Motil. 2014 May;26(5):654-9
references.pmid: 24533917
references.citation: Dysphagia. 2003 Summer;18(3):211-7
references.pmid: 14506987
references.citation: J Speech Lang Hear Res. 2000 Oct;43(5):1264-74
references.pmid: 11063246
references.citation: Am J Gastroenterol. 2010 May;105(5):981-7
references.pmid: 20179690
references.citation: Dysphagia. 2005 Winter;20(1):8-14
references.pmid: 15886961
references.citation: Dysphagia. 1988;3(1):1-10
references.pmid: 3073915
references.citation: Am J Gastroenterol. 1990 Jun;85(6):686-91
references.pmid: 2353687
references.citation: Dysphagia. 1989;4(2):90-4
references.pmid: 2640185
references.citation: J Speech Lang Hear Res. 2002 Jun;45(3):434-45
references.pmid: 12068997
references.citation: Otolaryngol Head Neck Surg. 2002 Oct;127(4):299-308
references.pmid: 12402009
references.citation: Am J Physiol. 1993 Mar;264(3 Pt 1):G427-32
references.pmid: 8460698
references.citation: Dysphagia. 2011 Mar;26(1):3-12
references.pmid: 21264672
references.citation: Dis Esophagus. 2010 Nov;23(8):670-4
references.pmid: 20545981
references.citation: J Gerontol A Biol Sci Med Sci. 1995 Sep;50(5):M257-62
references.pmid: 7671027
references.citation: Phys Med Rehabil Clin N Am. 2008 Nov;19(4):853-66, ix-x
references.pmid: 18940645
references.citation: Am J Physiol Gastrointest Liver Physiol. 2002 Jul;283(1):G16-26
references.pmid: 12065287
references.citation: Am J Physiol. 1995 Mar;268(3 Pt 1):G389-96
references.pmid: 7900799
references.citation: Dysphagia. 2014 Apr;29(2):223-33
references.pmid: 24402239
references.citation: Neurogastroenterol Motil. 2015 Feb;27(2):160-74
references.pmid: 25469569
references.citation: J Pediatr Gastroenterol Nutr. 2011 May;52 Suppl 1:S29-30
references.pmid: 21499042
references.citation: Head Neck. 2015 Aug;37(8):1122-9
references.pmid: 24841209
references.citation: Otolaryngol Head Neck Surg. 2010 Feb;142(2):208-13
references.pmid: 20115976
references.citation: Laryngoscope. 2010 Dec;120(12):2367-73
references.pmid: 21108425
references.citation: Am J Gastroenterol. 2011 Oct;106(10):1796-802
references.pmid: 21556039
references.citation: Br J Radiol. 1982 Apr;55(652):253-7
references.pmid: 7066633
references.citation: Eur Arch Otorhinolaryngol. 2011 Jun;268(6):941-4
references.pmid: 21431436
references.citation: Ann Otol Rhinol Laryngol. 2009 Feb;118(2):99-106
references.pmid: 19326759
references.citation: Am J Physiol. 1994 Jun;266(6 Pt 1):G972-7
references.pmid: 8023945
references.citation: J Appl Physiol (1985). 1993 Jul;75(1):33-7
references.pmid: 8376283
references.citation: Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G1037-48
references.pmid: 12842820
references.citation: Dysphagia. 2014 Apr;29(2):262-8
references.pmid: 24390651
references.citation: Ann Otol Rhinol Laryngol. 2009 Mar;118(3):190-8
references.pmid: 19374150
references.citation: Neurogastroenterol Motil. 2009 Aug;21(8):796-806
references.pmid: 19413684
references.citation: Clin Interv Aging. 2012;7:287-98
references.pmid: 22956864