title: [Evaluation of risk factors and prognosis on diodone-induced acute kidney injury according to ESUR and KDIGO criteria].
abstract: OBJECTIVE
  To investigate the incidence, risk factors and prognosis for contrast-induced acute kidney injury (CI-AKI) according to ESUR and KDIGO criteria in patients undergoing angiography.
  
  
  METHODS
  We evaluated 260 patients undergoing angiography and/or intervention therapy from April 2011 to January 2012 in the Second Xiangya Hospital of Central South University. All patients received low-osmolality contrast agent (ioversol). Serum creatinine was measured before angiography or at 48 or 72 h after procedure. The multivariate logistic regression was used to analyze the risk factors of CI-AKI. The major adverse events were observed in a year of follow-up.
  
  
  RESULTS
  Among the 260 patients, 23 experienced CI-AKI and the incidence was 8.8% according to ESUR criteria. Twelve patients experienced CI-AKI and the incidence was 4.6% according to KDIGO criteria. The multivariate logistic regression analysis showed that diabetes mellitus and dehydration were the independent risk factors for CI-AKI according to ESUR criteria; In another KDIGO criteria, chronic kidney disease (CKD), hypercholesterolemia and diabetes mellitus were the independent risk factors for CI-AKI. The prognosis study showed that the mortality of patients with CI-AKI were significantly higher than those without CI-AKI (P<0.05).
  
  
  CONCLUSIONS
  The incidence of CI-AKI is associated with diagnostic criteria. Diabetes mellitus, CKD, dehydration and hypercholesterolemia were the independent risk factors for CI-AKI. CI-AKI is a relevant factor for mortality in a year after angiography and/or intervention therapy.
authors.affiliation: Department of Nephrology, Second People's Hospital, Hefei 230000, China.
authors.forename: Nana
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Nephrology,Second Xiangya Hospital, Central South University; Renal Stem Cell Laboratory, Nephrology Institute, Central South University, Changsha 410011, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Nephrology,Second Xiangya Hospital, Central South University; Renal Stem Cell Laboratory, Nephrology Institute, Central South University, Changsha 410011, China.
authors.forename: Shaobin
authors.initials: S
authors.lastname: Duan
authors.affiliation: Department of Nephrology,Second Xiangya Hospital, Central South University; Renal Stem Cell Laboratory, Nephrology Institute, Central South University, Changsha 410011, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Lei
authors.affiliation: Department of Nephrology,Second Xiangya Hospital, Central South University; Renal Stem Cell Laboratory, Nephrology Institute, Central South University, Changsha 410011, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis* / Q000401:mortality; D000792:Angiography; D003287:Contrast Media / Q000009:adverse effects*; D003681:Dehydration / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007468:Iodopyracet / Q000009:adverse effects*; D016015:Logistic Models; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D003287:Contrast Media; D007468:Iodopyracet