title: Reversible cardiac hypertrophy induced by PEG-coated gold nanoparticles in mice.
abstract: Gold nanoparticles (GNPs) are attracting more and more attention for their great potential value in biomedical application. Currently, no study has been reported on the chronic cardiac toxicity of GNPs after repeated administration. Here we carried out a comprehensive evaluation of the chronic cardiac toxicity of GNPs to the heart. Polyethylene glycol (PEG) -coated GNPs at three different sizes (10, 30 and 50 nm) or PBS was administrated to mice via tail vein for 14 consecutive days. Then the mice were euthanized at 2 weeks, 4 weeks or 12 weeks after the first injection. The accumulation of GNPs in the mouse heart and their effects on cardiac function, structure, fibrosis and inflammation were analysized. GNPs with smaller size showed higher accumulation and faster elimination. None of the three sizes of GNPs affected cardiac systolic function. The LVIDd (left ventricular end-diastolicinner-dimension), LVMass (left ventricular mass) and HW/BW (heart weight/body weight) were significantly increased in the mice receiving 10 nm PEG-GNPs for 2 weeks, but not for 4 weeks or 12 weeks. These results indicated that the accumulation of small size GNPs can induce reversible cardiac hypertrophy. Our results provide the basis for the further biomedical applications of GNPs in cardiac diseases.
authors.affiliation: Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovasicular Receptors Research Beijing 100191, China.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Yang
authors.affiliation: Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovasicular Receptors Research Beijing 100191, China.
authors.forename: Aiju
authors.initials: A
authors.lastname: Tian
authors.affiliation: Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovasicular Receptors Research Beijing 100191, China.
authors.forename: Zijian
authors.initials: Z
authors.lastname: Li
mesh_terms: D000818:Animals; D015415:Biomarkers; D006332:Cardiomegaly / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D020099:Coated Materials, Biocompatible; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005355:Fibrosis; D006046:Gold / Q000737:chemistry; D006334:Heart Function Tests; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000648:ultrastructure; D051379:Mice; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D015415:Biomarkers; D020099:Coated Materials, Biocompatible; D016207:Cytokines; D018836:Inflammation Mediators; D011092:Polyethylene Glycols; D006046:Gold
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