title: The Actinobacterium Corynebacterium glutamicum, an Industrial Workhorse.
abstract: Starting as a glutamate producer, Corynebacterium glutamicum has played a variety of roles in the industrial production of amino acids, one of the most important areas of white biotechnology. From shortly after its genome information became available, C. glutamicum has been applied in various production processes for value-added chemicals, fuels, and polymers, as a key organism in industrial biotechnology alongside the surprising progress in systems biology and metabolic engineering. In addition, recent studies have suggested another potential for C. glutamicum as a synthetic biology platform chassis that could move the new era of industrial microbial biotechnology beyond the classical field. Here, we review the recent progress and perspectives in relation to C. glutamicum, which demonstrate it as one of the most promising and valuable workhorses in the field of industrial biotechnology.
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
authors.forename: Yoon-Ah
authors.initials: YA
authors.lastname: Na
authors.affiliation: Department of Biological Engineering, Inha University, Incheon 22212, Republic of Korea.
authors.forename: Eungsoo
authors.initials: E
authors.lastname: Kim
authors.affiliation: Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea.
authors.forename: Heung-Shick
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
authors.forename: Pil
authors.initials: P
authors.lastname: Kim
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D001709:Biotechnology / Q000379:methods; D048230:Corynebacterium glutamicum / Q000737:chemistry / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D018698:Glutamic Acid / Q000096:biosynthesis / Q000378:metabolism; D007218:Industrial Microbiology / Q000379:methods*; D060847:Metabolic Engineering / Q000379:methods
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D018698:Glutamic Acid
keywords: Corynebacterium glutamicum; industrial microbe; metabolic engineering; synthetic biology