title: Use of Optical Fiber Imported Intra-Tissue Photodynamic Therapy for Treatment of Moderate to Severe Acne Vulgaris.
abstract: BACKGROUND
  To treat moderate to severe acne vulgaris, we developed an optical fiber imported intra-tissue photodynamic therapy: the optical fiber irradiation 5-aminolevulinic acid photodynamic therapy (OFI-ALA-PDT). The aim of this study was to compare the treatment effect and tolerability of OFI-ALA-PDT versus traditional ALA-PDT in the treatment of moderate to severe acne vulgaris.
  
  
  METHODS
  60 patients with facial acne enrolled into this study were randomly divided into an OFI-ALA-PDT group and a traditional ALA-PDT group, with 30 patients in each group. The difference between these 2 groups was the red light irradiation methods used. In the OFI-ALA-PDT group we used intra-tissue irradiation (import the red light directly into the target lesion with optical fiber) for 5 min, while the traditional ALA-PDT group received whole-face irradiation for 20 min. All patients received 1 irradiation every 7 to 10 days for a total of 6 irradiations. Treatment effects and adverse reactions were recorded after the 4th and 6th irradiation, and at 4, 8, 16 weeks after the entire treatment.
  
  
  RESULTS
  After the 4th irradiation, significantly different effective rates were observed in these groups (90.0% for the OFI-ALA-PDT group and 66.7% for the control group). However, no significant difference in effective rate was recorded in the later observations. There were 182 adverse reactions in the OFI-ALA-PDT group and 497 in the control group, which showed a significant difference (P<0.05).
  
  
  CONCLUSIONS
  OFI-ALA-PDT showed improved treatment effective rate in the early stage of irradiation, and it had fewer adverse reactions.
authors.affiliation: Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: , Sichuan Medical University, Luzhou, Sichuan, China (mainland).
authors.forename: Dan
authors.initials: D
authors.lastname: Yuan
authors.affiliation: Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
authors.forename: Jin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
authors.forename: Xinyu
authors.initials: X
authors.lastname: Lin
authors.affiliation: Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
authors.forename: Shi
authors.initials: S
authors.lastname: Cheng
authors.affiliation: Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
authors.forename: Fumin
authors.initials: F
authors.lastname: Li
authors.affiliation: Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
authors.forename: Xiling
authors.initials: X
authors.lastname: Duan
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000622:Aminolevulinic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D016022:Case-Control Studies; D005500:Follow-Up Studies; D006801:Humans; D055100:Optical Fibers / Q000009:adverse effects; D010778:Photochemotherapy / Q000009:adverse effects
chemical_list: D000622:Aminolevulinic Acid
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