title: Selective extraction and determination of chlorogenic acid in fruit juices using hydrophilic magnetic imprinted nanoparticles.
abstract: In this paper, the novel hydrophilic magnetic molecularly imprinted nanoparticles were developed for selective separation and determination of chlorogenic acid in aqueous fruit juices. The polymers were prepared by using amino-functionalized magnetic nanoparticles as carriers, branched polyethyleneimine as functional monomer, and chlorogenic acid as template molecule. Branched polyethyleneimine with abundant active amino groups could react with template sufficiently, and its unique dendritic structure may amplify the number of the imprinted cavities. Meanwhile, it would improve the hydrophilicity of imprinted materials for attaining high extraction efficiency. The resulted polymers exhibit fast kinetics, high adsorption capacity, and favorable selectivity. In addition, the obtained nanoparticles were used as solid-phase extraction sorbents for selective isolation and determination of chlorogenic acid in peach, apple, and grape juices (0.92, 4.21, and 0.75 μg mL(-1), respectively).
authors.affiliation: School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China; Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an 710049, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address: ruixiagao@mail.xjtu.edu.cn.
authors.forename: Ruixia
authors.initials: R
authors.lastname: Gao
authors.affiliation: Department of Hepatobiliary Surgery, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Dechun
authors.initials: D
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China; Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an 710049, China.
authors.forename: Gaiyan
authors.initials: G
authors.lastname: He
authors.affiliation: School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China; Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an 710049, China.
authors.forename: Yuhai
authors.initials: Y
authors.lastname: Tang
authors.affiliation: School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: guozj@mail.xjtu.edu.cn.
authors.forename: Zengjun
authors.initials: Z
authors.lastname: Guo
mesh_terms: D002726:Chlorogenic Acid / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D000067030:Fruit and Vegetable Juices / Q000032:analysis*; D008280:Magnetics / Q000379:methods*; D054802:Molecular Imprinting / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000379:methods
chemical_list: D002726:Chlorogenic Acid
keywords: Branched polyethyleneimine; Chlorogenic acid; Hydrophilicity; Magnetic separation; Solid-phase extraction