title: In vivo photothermal treatment by the peritumoral injection of macrophages loaded with gold nanoshells.
abstract: Photothermal treatment methods have been widely studied for their target specificity and potential for supplementing the limitations of conventional surgical treatments. In this study, we conducted in vivo photothermal treatments using macrophages containing nanoshells as live vectors. We injected macrophages at the peritumoral sites and observed that they had penetrated into the tumor approximately 48 hours after injection. Afterwards, we irradiated with a near-infrared laser for 2 minutes at 1 W/cm(2), causing cancer cell death. Our study identified the optimal conditions of the photothermal treatment and confirmed the feasibility of its use in in vivo treatments.
authors.affiliation: Korea University, Department of Physics, Seoul, South Korea.
authors.forename: Taeseok Daniel
authors.initials: TD
authors.lastname: Yang
authors.affiliation: Korea University, Department of Physics, Seoul, South Korea.
authors.forename: Wonshik
authors.initials: W
authors.lastname: Choi
authors.affiliation: Korea University, Department of Physics, Seoul, South Korea.
authors.forename: Tai Hyun
authors.initials: TH
authors.lastname: Yoon
authors.affiliation: Korea University, Department of Physics, Seoul, South Korea.
authors.forename: Kyoung Jin
authors.initials: KJ
authors.lastname: Lee
authors.affiliation: Korea University, Department of Materials Science and Engineering, Seoul, South Korea.
authors.forename: Jae-Seung
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Korea University, Department of Materials Science and Engineering, Seoul, South Korea.
authors.forename: Jang Ho
authors.initials: JH
authors.lastname: Joo
authors.affiliation: Korea University, Department of Physiology, Seoul, South Korea.
authors.forename: Min-Goo
authors.initials: MG
authors.lastname: Lee
authors.affiliation: Korea University, Department of Physiology, Seoul, South Korea.
authors.forename: Hong Soon
authors.initials: HS
authors.lastname: Yim
authors.affiliation: Korea University, Department of Physiology, Seoul, South Korea.
authors.forename: Kyung Min
authors.initials: KM
authors.lastname: Choi
authors.affiliation: Korea University, Department of Physiology, Seoul, South Korea.
authors.forename: Byoungjae
authors.initials: B
authors.lastname: Kim
authors.affiliation: LivsMedInc., Seoul, South Korea.
authors.forename: Jung Joo
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: LivsMedInc., Seoul, South Korea.
authors.forename: Heejin
authors.initials: H
authors.lastname: Kim
authors.affiliation: Korea University, Department of Otolaryngology-Head and Neck Surgery, Seoul, South Korea.
authors.forename: Doh Young
authors.initials: DY
authors.lastname: Lee
authors.affiliation: Korea University, Department of Otolaryngology-Head and Neck Surgery, Seoul, South Korea.
authors.forename: Kwang-Yoon
authors.initials: KY
authors.lastname: Jung
authors.affiliation: Korea University, Department of Otolaryngology-Head and Neck Surgery, Seoul, South Korea.
authors.forename: Seung-Kuk
authors.initials: SK
authors.lastname: Baek
keywords: (170.0170) Medical optics and biotechnology; (170.5180) Photodynamic therapy; (350.5340) Photothermal effects
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