title: Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand.
abstract: BACKGROUND
  Colorectal polyps are common in Thailand, particularly in the northeastern region. The present study aimed to determine any correlation between Helicobacter pylori-associated gastritis and colorectal polyps in the Thai population.
  
  
  METHODS
  A total of 303 patients undergoing esophagogastroduodenoscopy with colonoscopy for investigation of chronic abdominal pain participated in this study from November 2014 to October 2015. A diagnosis of Helicobacter pylori associated gastritis was made if the bacteria were seen on histopathological examination and a rapid urease test was positive. Colorectal polyps were confirmed by histological examination of colorectal biopsies. Patient demographic data were analyzed for correlations.
  
  
  RESULTS
  The prevalence of colorectal polyps was 77 (25.4%), lesions being found more frequently in Helicobacter pylori infected patients than non-infected subjects [38.4% vs. 12.5%; Odds Ratio (OR) (95% CI): 2.26 (1.32 - 3.86), p < 0.01]. Patients with Helicobacter pylori - associated gastritis were at high risk of having adenomas featuring dysplasia [OR (95% CI): 1.15 (1.16 - 7.99); P = 0.02]. There was no varaition in location of polyps, age group, sex and gastric lesions with respect to Helicobacter pylori status.
  
  
  CONCLUSIONS
  This study showed that Helicobacter pylori associated gastritis is associated with an increased risk of colorectal polyps, especially adenomas with dysplasia in the Thai population. Patients with Helicobacter pylori-associated gastritis may benefit from concurrent colonoscopy for diagnosis of colorectal polyps as a preventive and early treatment for colorectal cancer.
authors.affiliation: Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology, Nakhon-Ratchasima, Thailand E-mail : Taweesak.t@sut.ac.th.
authors.forename: Taweesak
authors.initials: T
authors.lastname: Tongtawee
authors.forename: Soraya
authors.initials: S
authors.lastname: Kaewpitoon
authors.forename: Natthawut
authors.initials: N
authors.lastname: Kaewpitoon
authors.forename: Chavaboon
authors.initials: C
authors.lastname: Dechsukhum
authors.forename: Wilairat
authors.initials: W
authors.lastname: Leeanansaksiri
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Loyd
authors.forename: Likit
authors.initials: L
authors.lastname: Matrakool
authors.forename: Sukij
authors.initials: S
authors.lastname: Panpimanmas
mesh_terms: D000236:Adenoma / Q000209:etiology / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D003113:Colonoscopy / Q000379:methods; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000382:microbiology; D003430:Cross-Sectional Studies; D005260:Female; D005756:Gastritis / Q000150:complications* / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007417:Intestinal Polyps / Q000209:etiology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013785:Thailand; D055815:Young Adult