title: Primary Intracranial Leptomeningeal Melanomatosis.
abstract: Primary intracranial malignant melanoma is a very rare and highly aggressive tumor with poor prognosis. A 66-year-old female patient presented a headache that had been slowly progressing for several months. A large benign pigmented skin lesion was found on her back. A brain MRI showed multiple linear signal changes with branching pattern and strong enhancement in the temporal lobe. The cytological and immunohiostochemical cerebrospinal fluid examination confirmed malignant melanoma. A biopsy confirmed that the pigmented skin lesion on the back and the conjunctiva were benign nevi. We report a case of primary intracranial malignant melanoma and review relevant literatures.
authors.affiliation: Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea.
authors.forename: Do-Hyoung
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea.
authors.forename: Chan-Young
authors.initials: CY
authors.lastname: Choi
authors.affiliation: Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea.
authors.forename: Chae-Heuck
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Pathology, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea.
authors.forename: Mee
authors.initials: M
authors.lastname: Joo
keywords: CNS; Leptomeninges; Melanoma; Primary; Subarachnoid hemorrhage
references.citation: J Coll Physicians Surg Pak. 2013 Feb;23(2):157-9
references.pmid: 23374525
references.citation: Neurol India. 2011 May-Jun;59(3):413-9
references.pmid: 21743173
references.citation: J Neurosurg. 2004 Sep;101(3):528-31
references.pmid: 15352613
references.citation: AJNR Am J Neuroradiol. 2003 Jan;24(1):115-8
references.pmid: 12533338
references.citation: Neurosurgery. 2006 Jul;59(1):E206; discussion E206
references.pmid: 16823290
references.citation: J Neurooncol. 2011 Apr;102(2):323-8
references.pmid: 20640479
references.citation: Acta Neuropathol. 2007 Aug;114(2):97-109
references.pmid: 17618441
references.citation: Histopathology. 1997 Jun;30(6):576-81
references.pmid: 9205863
references.citation: Surg Neurol. 2001 Mar;55(3):163-8; discussion 168
references.pmid: 11311915
references.citation: J Neurol Neurosurg Psychiatry. 1976 Jun;39(6):526-30
references.pmid: 950562