title: Increased BMR in overweight and obese patients with type 2 diabetes may result from an increased fat-free mass.
abstract: The study aimed to determine the relationships between the basal metabolic rate (BMR) and body composition of overweight and obese Chinese adults with type 2 diabetes mellitus (DM). This cross-sectional clinical study enrolled 193 Chinese adults with type 2 DM who were overweight (24 kg/m(2)=BMI≤28 kg/m(2), n=99), or obese (BMI ≥28 kg/m(2), n=94). Ninety-seven adults with normal BMIs, including 50 DM patients and 47 healthy adults, were recruited as a control group. BMR was measured by indirect calorimetry; predicted BMR was calculated according to the Schofield equation; and the relationships between BMR, body composition, and biochemical results were determined by the Pearson correlation. The results showed that obese DM patients had significantly higher BMRs than both overweight patients (P<0.05) and patients with normal BMI did (P<0.05). The measured BMR was significantly lower than the predicted BMR (P<0.05) in all groups. Obese and overweight DM patients had significantly greater weight, waist circumference, hip circumference, BMI, body surface area, body fat percentage, fat mass, and fat-free mass than patients with normal BMI. Except for waist circumference, these body composition measurements were significantly increased in obese DM patients when compared with those in overweight DM patients (P<0.05). Fat-free mass was closely correlated with BMR in both DM patients (r=0.874, P<0.01) and in healthy controls (r=0.902, P<0.01). It was concluded that overweight and obese Chinese adults with type 2 DM had increased BMRs compared with normal-weight controls, which may result from the difference in fat-free mass.
authors.affiliation: Department of Endocrinology and Metabolism, Wuhan Center Hospital, Huazhong University of Science and Technology, Wuhan, 430014, China.
authors.forename: Min-Xian
authors.initials: MX
authors.lastname: Sun
authors.affiliation: Department of Endocrinology and Metabolism, Wuhan Center Hospital, Huazhong University of Science and Technology, Wuhan, 430014, China. zhaoshiwuhan@126.com.
authors.forename: Shi
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology and Metabolism, Wuhan Center Hospital, Huazhong University of Science and Technology, Wuhan, 430014, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Mao
authors.affiliation: Department of Endocrinology and Metabolism, Wuhan Center Hospital, Huazhong University of Science and Technology, Wuhan, 430014, China.
authors.forename: Zhong-Jing
authors.initials: ZJ
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolism, Wuhan Center Hospital, Huazhong University of Science and Technology, Wuhan, 430014, China.
authors.forename: Xu-Yan
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Metabolism, Wuhan Center Hospital, Huazhong University of Science and Technology, Wuhan, 430014, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Yi
mesh_terms: D000368:Aged; D001481:Basal Metabolism; D050218:Body Fat Distribution; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism*
keywords: basal metabolic rate; body composition; obese; overweight; type 2 diabetes mellitus
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