title: Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection.
abstract: In the current era of combination antiretroviral therapy (ART), human immunodeficiency virus (HIV)-infected individuals are living longer and healthier lives. Nevertheless, HIV-infected persons are at greater risk for age-related disorders, which have been linked to residual immune dysfunction and inflammation. HIV-infected individuals are almost universally co-infected with cytomegalovirus (CMV) and both viruses are associated with inflammation-related morbidities. Therefore, a detailed investigation of the relationship between CMV and aging-related morbidities emerging during chronic HIV infection is warranted. Here, we review the literature on how CMV co-infection affects HIV infection and host immunity and we discuss the gaps in our knowledge that need elucidation.
authors.affiliation: Case Western Reserve University/University Hospitals Case Medical Center, 2109 Adelbert Road, BRB 1048B, Cleveland, OH, 44106, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Freeman
authors.affiliation: Case Western Reserve University/University Hospitals Case Medical Center, 2109 Adelbert Road, BRB 1048B, Cleveland, OH, 44106, USA.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Lederman
authors.affiliation: University of California, San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA. gianella@ucsd.edu.
authors.forename: Sara
authors.initials: S
authors.lastname: Gianella
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D060085:Coinfection / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000821:virology; D019562:Viral Load; D014779:Virus Replication
chemical_list: D019380:Anti-HIV Agents
keywords: Aging; CMV infection; HIV infection; Immune response; Inflammation
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