title: Human olfactory stem cells for injured facial nerve reconstruction in a rat model.
abstract: The purpose of this study was to show the efficacy of olfactory stem cells for injured facial nerve reconstruction in a rat model.
  
  
  
  Olfactory stem cells were isolated from the olfactory mucosa of human participants. A 2-mm excision was performed on the right facial nerve of all rats. Reconstruction was performed with a conduit in group 1 (n = 9); a conduit and phosphate-buffered saline in group 2 (n = 9); and a conduit and labeled olfactory stem cell in group 3 (n = 9). Rats were followed for whisker movements and electroneuronography (ENoG) analyses.
  
  
  
  The whisker-movement scores for group 3 were significantly different from other groups (p < .001). ENoG showed that the amplitude values for group 3 were significantly different from group 1 and group 2 (p = .030; p < .001). Group 3 showed marked olfactory stem cell under a fluorescence microscope.
  
  
  
  This study suggests that olfactory stem cells may be used as a potent cellular therapy for accelerating the regeneration of peripheral nerve injuries. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2011-E2020, 2016.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Istanbul University Cerrahpasa Medicine Faculty, Istanbul, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Batioglu-Karaaltin
authors.affiliation: Department of Plastic and Reconstructive Surgery, Acibadem University Medicine Faculty, Istanbul, Turkey.
authors.forename: Mehmet Veli
authors.initials: MV
authors.lastname: Karaaltin
authors.affiliation: Bioengineering Department, Yildiz Technical University, Faculty of Chemistry and Metallurgical Engineering, Istanbul, Turkey.
authors.forename: Olga Nehir
authors.initials: ON
authors.lastname: Oztel
authors.affiliation: Acibadem Labcell Laboratories, Istanbul, Turkey.
authors.forename: Ercument
authors.initials: E
authors.lastname: Ovali
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Belit Merve
authors.initials: BM
authors.lastname: Sener
authors.affiliation: EMG Laboratories, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Turgut
authors.initials: T
authors.lastname: Adatepe
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Yigit
authors.affiliation: Department of Pathology, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Erol
authors.initials: E
authors.lastname: Bozkurt
authors.affiliation: Bioengineering Department, Yildiz Technical University, Faculty of Chemistry and Metallurgical Engineering, Istanbul, Turkey.
authors.forename: Serap Yesilkir
authors.initials: SY
authors.lastname: Baydar
authors.affiliation: Bioengineering Department, Yildiz Technical University, Faculty of Chemistry and Metallurgical Engineering, Istanbul, Turkey.
authors.forename: Melahat
authors.initials: M
authors.lastname: Bagirova
authors.affiliation: Department of Neurology, Istanbul University Cerrahpasa Medicine Faculty, Istanbul, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Uzun
authors.affiliation: Bioengineering Department, Yildiz Technical University, Faculty of Chemistry and Metallurgical Engineering, Istanbul, Turkey.
authors.forename: Adil
authors.initials: A
authors.lastname: Allahverdiyev
mesh_terms: D000818:Animals; D005154:Facial Nerve / Q000601:surgery*; D020220:Facial Nerve Injuries / Q000601:surgery*; D006801:Humans; D009416:Nerve Regeneration; D009831:Olfactory Mucosa / Q000166:cytology*; D051381:Rats; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology
keywords: axonal nerve damage; facial nerve; olfactory mucosa; reconstruction; stem cells