title: Pharmacokinetic Parameters Determination and In Vitro-In Vivo Correlation of Ileocolonic-Targeted pH-Responsive Coated Mini-Tablets of Naproxen.
abstract: This research work aims to determine the pharmacokinetic parameters and in vitro-in vivo correlation of the selected ileocolonic-targeted coated mini-tablet filled capsule formulation of naproxen. The pure suspension and coated mini-tablet filled capsule formulation of naproxen were administered to adult albino rabbits through the oral route. The samples were analyzed for naproxen by an HPLC method. For the pure drug suspension, the peak plasma concentration was found as 8.499±0.029 μg/ml at 1.139±0.010 hours and the half-life was found to be 9.459±0.387 hours, whereas for the formulation the peak plasma concentration was found as 6.814±0.037 μg/ml at 8.042±0.069 hours and the half-life was found to be 19.657±0.359 hours. This decreased the peak plasma concentration at a delayed time and increased the half-life of the capsule formulation in comparison with the pure drug suspension which showed that naproxen was only targeted to the ileocolonic region. A significant in vitro-in vivo correlation (i.e. R(2)=0.9901) was also obtained. Thus, the results of these findings suggest that naproxen formulated as coated mini-tablets can be suitable for targeted ileocolonic drug delivery.
authors.affiliation: Department of Pharmaceutics, Bhaskar Pharmacy College, Yenkapally (V), Moinabad (M), R. R. District, Hyderabad-500075, Telangana, India.
authors.forename: Mohd Abdul
authors.initials: MA
authors.lastname: Hadi
authors.affiliation: Department of Pharmaceutics, Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Thimmapur, Karimnagar-505001, Telangana, India.
authors.forename: Nidagurthi Guggilla
authors.initials: NG
authors.lastname: Raghavendra Rao
authors.affiliation: Bhaskar Pharmacy College, Yenkapally (V), Moinabad (M), R. R. District, Hyderabad-500075, Telangana, India.
authors.forename: Avanapu
authors.initials: A
authors.lastname: Srinivasa Rao
keywords: Coated-mini-tablets; Eudragit L100; Eudragit S100; Naproxen; Rabbits
references.citation: Br J Clin Pharmacol. 1982 Sep;14 (3):405-8
references.pmid: 7126413
references.citation: Int J Clin Pharmacol Ther Toxicol. 1992 May;30(5):153-9
references.pmid: 1592542
references.citation: Ann Rheum Dis. 1994 Aug;53(8):521-4
references.pmid: 7944637
references.citation: Gut. 1988 Aug;29(8):1035-41
references.pmid: 3410329
references.citation: Int J Pharm. 2005 Nov 23;305(1-2):22-30
references.pmid: 16236475
references.citation: J Antimicrob Chemother. 2003 Dec;52(6):981-6
references.pmid: 14613962
references.citation: Pharm Res. 2008 Aug;25(8):1828-35
references.pmid: 18465212
references.citation: J Pharm Sci. 2006 Dec;95(12):2760-6
references.pmid: 16917845
references.citation: J Pharm Pharm Sci. 2006;9(2):169-89
references.pmid: 16959187
references.citation: Pak J Pharm Sci. 2015 Jan;28(1):185-93
references.pmid: 25553695
references.citation: J Zhejiang Univ Sci B. 2012 May;13(5):348-55
references.pmid: 22556172
references.citation: Pharm Res. 1990 Nov;7(11):1167-71
references.pmid: 2293217