title: A visco-poroelastic model of functional adaptation in bones reconstructed with bio-resorbable materials.
abstract: In this paper, the phenomena of resorption and growth of bone tissue and resorption of the biomaterial inside a bicomponent system are studied by means of a numerical method based on finite elements. The material behavior is described by a poro-viscoelastic model with infiltrated voids. The mechanical stimulus that drives these processes is a linear combination of density of strain energy and viscous dissipation. The external excitation is represented by a bending load slowly variable with sinusoidal law characterized by different frequencies. Investigated aspects are the influence of the load frequency, of type of the stimulus and of the effective porosity on the time evolution of the mass densities of considered system.
authors.affiliation: Department of Structural and Geotechnical Engineering, Università di Roma La Sapienza, 18 Via Eudossiana, Rome, Italy. ivan.giorgio@uniroma1.it.
authors.forename: Ivan
authors.initials: I
authors.lastname: Giorgio
authors.affiliation: Department of Structural and Geotechnical Engineering, Università di Roma La Sapienza, 18 Via Eudossiana, Rome, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Andreaus
authors.affiliation: International Research Center for the Mathematics and Mechanics of Complex Systems - MeMoCS, Università dell'Aquila, Cisterna di Latina, Italy.
authors.forename: Daria
authors.initials: D
authors.lastname: Scerrato
authors.affiliation: Department of Structural and Geotechnical Engineering, Università di Roma La Sapienza, 18 Via Eudossiana, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: dell'Isola
mesh_terms: D000222:Adaptation, Physiological; D001672:Biocompatible Materials / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects; D000071556:Cancellous Bone / Q000187:drug effects / Q000502:physiology*; D003198:Computer Simulation; D004548:Elasticity; D020342:Finite Element Analysis; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D016062:Porosity; D013314:Stress, Mechanical; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials
keywords: Bone functional adaptation; Continuum mixture model; Dissipation; Mechanical–biological coupling; Poro-viscoelasticity