title: Bigger Isn't Always Better: Cell Size and the Spindle Assembly Checkpoint.
abstract: Variation in the activity of the spindle assembly checkpoint has been observed in different cell types, yet the reason for this variability remains poorly understood. Reporting in Developmental Cell, Galli and Morgan (2016) show that checkpoint activity increases during development as cell size, and the cytoplasm-to-kinetochore ratio, decreases.
authors: Institute of Research in Immunology and Cancer (IRIC), Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC H3C 3J7, Canada. Electronic address: abigail.gerhold@umontreal.ca.
authors: Abigail R
authors: AR
authors: Gerhold
authors: Institute of Research in Immunology and Cancer (IRIC), Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC H3C 3J7, Canada; Department of Pathology and Cell Biology, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC H3C 3J7, Canada.
authors: Jean-Claude
authors: JC
authors: Labbé
authors: Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: pmaddox@unc.edu.
authors: Paul S
authors: PS
authors: Maddox
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology*; D018386:Kinetochores / Q000378:metabolism*; D059566:M Phase Cell Cycle Checkpoints / Q000235:genetics*; D008870:Microtubules / Q000378:metabolism*; D008941:Spindle Apparatus / Q000235:genetics*