title: Chrysobalanus icaco L. Leaves Normalizes Insulin Sensitivity and Blood Glucose and Inhibits Weight Gain in High-Fat Diet-Induced Obese Mice.
abstract: Chrysobalanus icaco L. is a medicinal plant present in the Brazilian coastline and known for its hypoglicemic and antioxidant properties. Here, we assessed the beneficial metabolic effects of the aqueous extract of C. icaco (AECI) leaves in diet-induced obese mice. Swiss mice were fed standard chow (SC used as controls) or high-fat diet (HFD) to induce obesity. After 10 weeks, mice on each diet were divided into two groups with one group used as control while the other group treated with AECI for 4 weeks resulting in four groups of mice: SC; SC treated with AECI (SC + AECI); HFD; and HFD treated with AECI (HFD + AECI). AECI was administered drinking water at about 200 mg/kg. AECI was able to normalize insulin (13,682 ± 1090 vs. 9828 ± 485 AU, P < .05) and fasting blood glucose (192.8 ± 14.2 vs. 132.3 ± 6.4 mg/dL, P < .05) and inhibit weight gain (39 ± 5.7%) and fat storage in liver (72.60 ± 3.83%, P < .0001), despite the high-fat intake. These findings reinforce the use of AECI in hyperglycemia and highlight the potential extract's effect in preventing weight gain and fat accumulation in liver of diet-induced obese mice.
authors: 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
authors: Pollyanna A S
authors: PA
authors: White
authors: 2 Núcleo de Nutrição, Universidade Federal de Sergipe , São Cristóvão, Brazil .
authors: Jessica M D
authors: JM
authors: Araújo
authors: 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
authors: Luana M
authors: LM
authors: Cercato
authors: 2 Núcleo de Nutrição, Universidade Federal de Sergipe , São Cristóvão, Brazil .
authors: Lucas A
authors: LA
authors: Souza
authors: 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
authors: Ana Paula Oliveira
authors: AP
authors: Barbosa
authors: 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
authors: Lucindo José
authors: LJ
authors: Quintans-Junior
authors: 3 Department of Physiology and Biophysic, Universidade de São Paulo , São Paulo, Brazil .
authors: Ubiratan F
authors: UF
authors: Machado
authors: 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
authors: Enilton A
authors: EA
authors: Camargo
authors: 2 Núcleo de Nutrição, Universidade Federal de Sergipe , São Cristóvão, Brazil .
authors: Luciana C
authors: LC
authors: Brito
authors: 1 Department of Physiology, Universidade Federal de Sergipe , São Cristóvão, Brazil .
authors: Marcio Roberto V
authors: MR
authors: Santos
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight; D001938:Brazil; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D045469:Chrysobalanaceae / Q000737:chemistry*; D003404:Creatinine / Q000097:blood; D059305:Diet, High-Fat; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood; D015430:Weight Gain / Q000187:drug effects*; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D010936:Plant Extracts; D014280:Triglycerides; D014508:Urea; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Chrysobalanaceae; Chrysobalanus icaco; adipose tissue; blood glucose; insulin resistance; mice; obesity