title: Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease.
abstract: OBJECTIVE
  To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically.
  
  
  METHODS
  A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains.
  
  
  RESULTS
  Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features.
  
  
  CONCLUSIONS
  Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Romuald
authors: R
authors: Girard
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Omaditya
authors: O
authors: Khanna
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Robert
authors: R
authors: Shenkar
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Lingjiao
authors: L
authors: Zhang
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Meijing
authors: M
authors: Wu
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Michael
authors: M
authors: Jesselson
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Hussein A
authors: HA
authors: Zeineddine
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Anupriya
authors: A
authors: Gangal
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Maged D
authors: MD
authors: Fam
authors: Recursion Pharmaceuticals, Salt Lake City, UT 84108, USA.
authors: Christopher C
authors: CC
authors: Gibson
authors: Division of Cardiology & Department of Medicine at the University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132, USA.
authors: Kevin J
authors: KJ
authors: Whitehead
authors: Division of Cardiology & Department of Medicine at the University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132, USA.
authors: Dean Y
authors: DY
authors: Li
authors: Section of Cardiology, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: James K
authors: JK
authors: Liao
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Changbin
authors: C
authors: Shi
authors: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
authors: Issam A
authors: IA
authors: Awad
mesh_terms: D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood*; D002908:Chronic Disease; D003710:Demography; D005260:Female; D020786:Hemangioma, Cavernous, Central Nervous System / Q000097:blood* / Q000473:pathology*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000097:blood*; D054460:rho-Associated Kinases / Q000378:metabolism
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D014807:Vitamin D; D002097:C-Reactive Protein; D054460:rho-Associated Kinases
keywords: aggressiveness; biomarker; cerebral cavernous malformation; inflammation; non-HDL cholesterol; vitamin D