title: Autism Spectrum Disorder in the DSM-5: Diagnostic Sensitivity and Specificity in Early Childhood.
abstract: Changes to the DSM-5 Autism Spectrum Disorder (ASD) criteria raised concerns among parents and practitioners that the criteria may exclude some children with Pervasive Developmental Disorder (PDD). Few studies have examined DSM-5 sensitivity and specificity in children less than 5 years of age. This study evaluated 185 children aged 20-55 months with DSM-IV PDD or developmental delay. Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) data was assigned to DSM-5 subdomains. Children displaying the required symptomatology were classified with DSM-5 ASD. DSM-IV clinical diagnoses were compared to DSM-5 classifications. Using combined ADI-R/ADOS information, sensitivity was .84 and specificity was .54. Comorbid behaviour and emotional problems were significantly lower in children with PDD that did not meet DSM-5 criteria.
authors: Centre for Developmental Psychiatry and Psychology, Department of Psychiatry, School of Clinical Sciences, Monash University, Notting Hill, VIC, Australia.
authors: Jessica A
authors: JA
authors: Christiansz
authors: Centre for Developmental Psychiatry and Psychology, Department of Psychiatry, School of Clinical Sciences, Monash University, Notting Hill, VIC, Australia. kylie.gray@monash.edu.|Centre for Developmental Psychiatry and Psychology, Early in Life Mental Health Services, Monash Medical Centre, 246 Clayton Rd, Clayton, VIC, 31768, Australia. kylie.gray@monash.edu.
authors: Kylie M
authors: KM
authors: Gray
authors: Centre for Developmental Psychiatry and Psychology, Department of Psychiatry, School of Clinical Sciences, Monash University, Notting Hill, VIC, Australia.
authors: John
authors: J
authors: Taffe
authors: Centre for Developmental Psychiatry and Psychology, Department of Psychiatry, School of Clinical Sciences, Monash University, Notting Hill, VIC, Australia.
authors: Bruce J
authors: BJ
authors: Tonge
mesh_terms: D000342:Affective Symptoms / Q000145:classification / Q000175:diagnosis / Q000523:psychology; D000067877:Autism Spectrum Disorder / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D002648:Child; D002653:Child Behavior Disorders / Q000145:classification / Q000175:diagnosis / Q000523:psychology; D002659:Child Development Disorders, Pervasive / Q000145:classification / Q000175:diagnosis / Q000523:psychology; D002675:Child, Preschool; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012680:Sensitivity and Specificity
keywords: ADI-R; ADOS; Autism Spectrum Disorder; DSM-5; Diagnosis