title: Free thyroxine in needle washout after fine needle aspiration biopsy of toxic thyroid nodules.
abstract: The main diagnostic tool for toxic adenomas (TA) is radionuclide imaging indicated in patients with evidence of thyroid nodules in combination with thyrotoxic syndrome. Thyroid ultrasound and fine-needle aspiration biopsy (FNAB) are widely used for the valuation of thyroid masses. There is no literature data concerning the utility of FNAB and related tests for the diagnosis of hyperfunctioning thyroid nodules. The purpose of this study is to determine the levels of free thyroxine (FT4) in the needle washout after FNAB of hot thyroid nodules. The results of our study show that the FT4 levels in needle washout from TA were significantly higher than the surrounding parenchyma and correlated with the hormonal changes in patients with thyroid hyperfunctioning nodules. Further studies on a large number of patients are needed to refine the diagnostic value of this method and evaluate its importance in quantitative risk assessment of thyroid autonomy.
authors: Nikolai
authors: N
authors: Raikov
authors: Boyan
authors: B
authors: Nonchev
authors: Department of Nuclear Medicine and Metabolic Therapy. bchaushev@gmail.com.
authors: Borislav
authors: B
authors: Chaushev
authors: Diyana
authors: D
authors: Vjagova
authors: Svetoslav
authors: S
authors: Todorov
authors: Yana
authors: Y
authors: Bocheva
authors: Daniela
authors: D
authors: Malceva
authors: Snejinka
authors: S
authors: Vicheva
authors: Asyia
authors: A
authors: Raikova
authors: Antoaneta
authors: A
authors: Argatska
authors: Miroslav
authors: M
authors: Raikov
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016606:Thyroid Nodule / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000378:metabolism*; D014463:Ultrasonography
chemical_list: D013972:Thyrotropin; D013974:Thyroxine
keywords: fine-needle aspiration biopsy (FNAB); hot thyroid nodules — toxic adenoma (TA); thyroid radionuclide imaging