title: New adipokines.
abstract: Adipose tissue is now widely recognized as "an organ" able to synthesize and secrete hundred factors collectively called adipokines. These secreted molecules exert pleiotropic actions, notably on the regulation of glucose and lipid metabolism, inflammation, reproduction, or angiogenesis. Over the past two decades, a considerable amount of work was performed on the two "star" adipokines, leptin and adiponectin, particularly because of their involvement in energy metabolism. The present review is focused on the three most recently discovered adipokines that are clearly emerging as important actors in metabolism: apelin, fibroblast growth factor-21, and neuroregulin-4. Moreover, given a number of clinical and experimental data, these three adipokines represent promising targets in the context of metabolic disorders associated with obesity.
authors: UMR_S 938 CDR-Saint-Antoine, faculté de médecine, Sorbonne Universities UPMC Paris 6, 27, rue de Chaligny, 75012 Paris, France; University Hospital ICAN Institute, 75013 Paris, France; Endocrinology, Saint-Antoine Hospital, AP-HP, 75012 Paris, France. Electronic address: bfeve@free.fr.
authors: Bruno
authors: B
authors: Fève
authors: Service de chirurgie digestive et viscérale, Centre hospitalier Sud Francilien, 91000 Corbeil-Essonnes, France.
authors: Claire
authors: C
authors: Bastard
authors: UMR_S 938 CDR-Saint-Antoine, faculté de médecine, Sorbonne Universities UPMC Paris 6, 27, rue de Chaligny, 75012 Paris, France; University Hospital ICAN Institute, 75013 Paris, France; Biochemistry Department, hôpital Tenon, AP-HP, 75020 Paris, France.
authors: Soraya
authors: S
authors: Fellahi
authors: UMR_S 938 CDR-Saint-Antoine, faculté de médecine, Sorbonne Universities UPMC Paris 6, 27, rue de Chaligny, 75012 Paris, France; University Hospital ICAN Institute, 75013 Paris, France; Biochemistry Department, hôpital Tenon, AP-HP, 75020 Paris, France.
authors: Jean-Philippe
authors: JP
authors: Bastard
authors: UMR_S 938 CDR-Saint-Antoine, faculté de médecine, Sorbonne Universities UPMC Paris 6, 27, rue de Chaligny, 75012 Paris, France; University Hospital ICAN Institute, 75013 Paris, France; Biochemistry Department, hôpital Tenon, AP-HP, 75020 Paris, France.
authors: Jacqueline
authors: J
authors: Capeau
mesh_terms: D054392:Adipokines / Q000502:physiology; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D000073861:Apelin; D004734:Energy Metabolism; D005346:Fibroblast Growth Factors / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D050356:Lipid Metabolism; D008099:Liver; D020880:Neuregulins / Q000502:physiology; D009765:Obesity; D012098:Reproduction
chemical_list: C115436:APLN protein, human; D054392:Adipokines; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins; D020880:Neuregulins; C414620:fibroblast growth factor 21; C467747:neuregulin-4; D005346:Fibroblast Growth Factors; D005947:Glucose
keywords: Adipocyte; Adipokine; Adipose tissue; Apelin; Apéline; Fibroblast growth factor-21; Insulin resistance; Insulinorésistance; Neuroregulin-4; Neuroréguline-4; Obesity; Obésité; Tissu adipeux