title: Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism.
abstract: The renal resistive index (RI) calculated by Doppler ultrasonography has been reported to be correlated with renal structural changes and outcomes in patients with essential hypertension or renal disease. However, little is known about this index in primary aldosteronism. In this prospective study, we examined the utility of this index to predict blood pressure (BP) outcome after adrenalectomy in patients with primary aldosteronism. We studied 94 patients with histopathologically proven aldosteronoma who underwent surgery. Parameters on renal function, including renal flow indices, were examined and followed up for 12 months postoperatively. The renal RI of the main, hilum, and interlobar arteries was significantly higher in patients with aldosteronoma compared with 100 control patients. BP, estimated glomerular filtration rate, and urinary albumin excretion significantly decreased after adrenalectomy. The resistive indices of all compartment arteries were significantly reduced 1 month after adrenalectomy and remained stable for 12 months. Patients whose interlobar RI was in the highest tertile at baseline had higher systolic BP after adrenalectomy than those whose RI was in the lowest tertile. Logistic regression analysis demonstrated that the RI of the interlobar and hilum arteries could be an independent predictive marker for intractable hypertension (systolic BP ≥140 mm Hg, increased BP, taking ≥3 antihypertensive agents, or increased number of agents) even after adrenalectomy. Therefore, in patients with aldosteronoma, the renal RI indicates partially reversible renal hemodynamics and renal structural damages that would influence postoperative BP outcome.
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Yoshitsugu
authors: Y
authors: Iwakura
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Sadayoshi
authors: S
authors: Ito
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Ryo
authors: R
authors: Morimoto
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Masataka
authors: M
authors: Kudo
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Yoshikiyo
authors: Y
authors: Ono
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Masahiro
authors: M
authors: Nezu
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Kei
authors: K
authors: Takase
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Kazumasa
authors: K
authors: Seiji
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Shigeto
authors: S
authors: Ishidoya
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Yoichi
authors: Y
authors: Arai
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Yasuharu
authors: Y
authors: Funamizu
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Takashi
authors: T
authors: Miki
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Yasuhiro
authors: Y
authors: Nakamura
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.).
authors: Hironobu
authors: H
authors: Sasano
authors: From the Endocrine unit of the Division of Nephrology, Endocrinology and Vascular Medicine (Y.I., S.I., R.M., M.K., Y.O., M.N., F.S.), Departments of Diagnostic Radiology (K.T., K.S.) and Urology (S.I, Y.A.), Clinical Physiology Center (Y.F., T.M.), Department of Pathology (Y.N., H.S.), Tohoku University Hospital, Sendai, Japan; and Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan (F.S.). fsatoh@med.tohoku.ac.jp.
authors: Fumitoshi
authors: F
authors: Satoh
mesh_terms: D000315:Adrenalectomy; D001794:Blood Pressure; D018450:Disease Progression; D000075222:Essential Hypertension; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012189:Retrospective Studies; D018608:Ultrasonography, Doppler; D014655:Vascular Resistance / Q000502:physiology*
keywords: adrenalectomy; blood pressure; hyperaldosteronism; hypertension; ultrasonography, Doppler