title: Total Synthesis of a Diacetonide Derivative of Thuggacin A.
abstract: A highly stereoselective total synthesis of the diacetonide derivative of the antibiotic thuggacin A has been described. The synthesis features the stereoselective Stille cross-coupling reaction to set up the whole carbon framework, aldol condensation to construct the highly substituted conjugated diene, non-Evans syn aldol, CBS reduction, Hantzsch's thiazole synthesis, Horner-Wadsworth-Emmons reaction, and Shiina's macrolactonization.
authors: Academy of Scientific and Innovative Research, Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad-500007, India.
authors: Jhillu S
authors: JS
authors: Yadav
authors: Academy of Scientific and Innovative Research, Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad-500007, India.
authors: Palash
authors: P
authors: Dutta
mesh_terms: D007783:Lactones / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D018942:Macrolides; C523035:thuggacin A