title: A retrospective comparison of early stage primary extranodal with nodal non-Hodgkin lymphoma patients: A single center experience.
abstract: OBJECTIVE
  The primary extranodal non Hodgkin's lymphoma 'EN-NHL) is a heterogeneous group of diseases with expression of different oncogenes compared to nodal NHLs. In this study, we aimed to compare the clinical and pathological findings, the prognostic factors, the treatment and the survival data in patients with stage I-II primary EN-NHL with nodal NHL 'N-NHL).
  
  
  METHODS
  Between January 1991 and January 2014, 853 patients with diagnosis of NHL were reviewed. Of 853 patients, 379 '44%) with stage I-II disease were included in the study and were divided into two groups according to involved sites as nodal and extranodal. The N-NHL group consisted of stage I-II patients without extranodal involvement, who were diagnosed by incisional or excisional lymph node biopsy. The EN-NHL group consisted of patients with a single primary extranodal involvement and/or a locoregional lymph node involvement, and who were diagnosed by means of a biopsy from the extranodal region.
  
  
  RESULTS
  A total of 112 patients with N-NHL and 267 with EN-NHL were enrolled in the study. About 3/4 of the N-NHL patients had stage II, while 50% of the EN-NHL patients had stage I 'p<0.01). There was no statistically significant difference between EN-NHL and NHL in terms of 5-year overall survival '0S) 'p=0.25). The median 5-year OS in the diffuse large B cell lymphoma 'DLBCL) subgroup with N-NHL was 52%, while that of the EN-NHL was 68% 'p=0.006).
  
  
  CONCLUSIONS
  Patients with stage I-II N-NHL had a poorer prognosis than EN-NHL patients. However, 5-year OS rates were similiar between groups.
authors: Department of Medical Oncology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors: Dogan
authors: D
authors: Yazilitas
authors: Nuriye
authors: N
authors: Ozdemir
authors: Cemil
authors: C
authors: Hocazade
authors: Yakup
authors: Y
authors: Bozkaya
authors: Ozan
authors: O
authors: Yazici
authors: Mehmet Ali Nahit
authors: MA
authors: Sendur
authors: Nurullah
authors: N
authors: Zengin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies