title: [GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY].
abstract: Glycine receptor is the anion-selective channel, providing fast synaptic transmission in the central nervous system of vertebrates. Together with the nicotinic acetylcholine, GABA and serotonin (5-HT3R) receptors, it belongs to the superfamily of pentameric cys-loop receptors. In this review we briefly describe main functions of these transmembrane proteins, their distribution and molecular architecture. Special attention is paid to recent studies on the molecular physiology of these receptors, as well as on presenting of molecular domains responsible for their dysfunction.
authors: G V
authors: GV
authors: Maleeva
authors: P D
authors: PD
authors: Bregestovski
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism / Q000503:physiopathology; D015870:Gene Expression; D006801:Humans; D017136:Ion Transport; D009154:Mutation; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D018079:Receptors, GABA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D018009:Receptors, Glycine / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D044406:Receptors, Serotonin, 5-HT3 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013216:Reflex, Startle / Q000235:genetics*; D012701:Serotonin / Q000378:metabolism; D009435:Synaptic Transmission
chemical_list: C114561:GLRB protein, human; D018079:Receptors, GABA; D018009:Receptors, Glycine; D011978:Receptors, Nicotinic; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin; D000109:Acetylcholine