title: [Lymphomatoid papulosis: a clinicopathologic study of 22 cases].
abstract: OBJECTIVE
  To investigate the clinical presentation, histopathological features, progression, and treatment of lymphomatoid papulosis (LyP).
  
  
  METHODS
  A retrospective review was performed on clinicopathological data of 22 patients diagnosed with LyP from June 2010 to March 2015 in Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College.
  
  
  RESULTS
  The mean age of the 22 LyP patients was 39 years (range: 7-83 years). The male-to-female ratio was 1:1. The areas predominantly affected were the trunks, followed by limbs and face. Most lesions presented as recurrent eruption of erythema, papule, nodules, ulcer, necrosis and crusting. Some of them leaved hyperpigmentation or atrophic scars on healing. Histopathologically, LyP were devided into types A, B, C, D and E, with 12, 1, 1, 3, and 4 cases in each type, respectively, and one case of mixed type B and C. One of the patients was also diagnosed with primary cutaneous anaplastic large-cell lymphoma besides the diagnosis of LyP. Among the 15 patients with follow-up information available, 11 patients were treated with regimens including oral corticosteroids, methotrexate, tripchlorolide, intramuscular injection of interferon, phototherapy, and topical corticosteroids. The mean follow-up time was 22 (1-54) months.All the patients were alive at the end of the follow-up period.
  
  
  CONCLUSIONS
  LyP is a low-grade malignant T-cell lymphoma with a benign clinical course but histologically malignant features. Multi-agent chemotherapy is unnecessary. Patients with LyP are likely to have an favorable prognosis.
authors: Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
authors: Jingshu
authors: J
authors: Xiong
authors: Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; Email: ch76ch@163.com.
authors: Hao
authors: H
authors: Chen
authors: Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
authors: Yiqun
authors: Y
authors: Jiang
authors: Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
authors: Xiulian
authors: X
authors: Xu
authors: Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
authors: Wei
authors: W
authors: Zhang
authors: Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
authors: Xuesi
authors: X
authors: Zeng
authors: Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
authors: Jianfang
authors: J
authors: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D000068476:Beijing; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D017731:Lymphomatoid Papulosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012878:Skin Neoplasms; D055815:Young Adult