title: Mesostructured silica and aluminosilicate carriers for oxytetracycline delivery systems.
abstract: Oxytetracycline delivery systems containing various MCM-type silica and aluminosilicate with different antibiotic content were developed in order to establish the influence of the support structural and textural properties and aluminum content on the drug release profile. The antibiotic molecules were loaded into the support mesochannels by incipient wetness impregnation method using a drug concentrated aqueous solution. The carriers and drug-loaded materials were investigated by small- and wide-angle XRD, FTIR spectroscopy, TEM and N2 adsorption-desorption isotherms. Faster release kinetics of oxytetracycline from uncalcined silica and aluminosilicate supports was observed, whereas higher drug content led to lower delivery rate. The presence of aluminum into the silica network also slowed down the release rate. The antimicrobial assays performed on Staphylococcus aureus clinical isolates showed that the oxytetracycline-loaded materials containing MCM-41-type mesoporous silica or aluminosilicate carriers inhibited the bacterial development.
authors: University "Politehnica" of Bucharest, Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Polizu street no. 1-7, Bucharest 011061, Romania. Electronic address: danaberger01@yahoo.com.
authors: D
authors: D
authors: Berger
authors: University "Politehnica" of Bucharest, Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Polizu street no. 1-7, Bucharest 011061, Romania.
authors: S
authors: S
authors: Nastase
authors: University "Politehnica" of Bucharest, Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Polizu street no. 1-7, Bucharest 011061, Romania.
authors: R A
authors: RA
authors: Mitran
authors: University "Politehnica" of Bucharest, Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Polizu street no. 1-7, Bucharest 011061, Romania.
authors: M
authors: M
authors: Petrescu
authors: University "Politehnica" of Bucharest, Department of Oxide Materials Science & Engineering, Polizu street no. 1-7, Bucharest 011061, Romania.
authors: E
authors: E
authors: Vasile
authors: University "Politehnica" of Bucharest, Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Polizu street no. 1-7, Bucharest 011061, Romania.
authors: C
authors: C
authors: Matei
authors: Ovidius University of Constanta, Faculty of Pharmacy, Aleea Universitatii no. 1, Constanta 900470, Romania.
authors: T
authors: T
authors: Negreanu-Pirjol
mesh_terms: D000327:Adsorption; D000538:Aluminum Silicates / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D007700:Kinetics; D010118:Oxytetracycline / Q000737:chemistry* / Q000494:pharmacology; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000538:Aluminum Silicates; D004337:Drug Carriers; C509968:MCM-41; C049037:aluminosilicate; D012822:Silicon Dioxide; D010118:Oxytetracycline
keywords: Aluminosilicates; Drug delivery system; MCM-41; Oxytetracycline; Staphylococcus aureus clinical strains