title: Allergic contact dermatitis due to cosmetics: A clinical and epidemiological study in a tertiary hospital.
abstract: The incidence of allergic contact dermatitis (ACD) to cosmetics in the general population is rising with the increasing use of cosmetic products and their proliferation and diversification. The aims of this study were to determine the prevalence of ACD to cosmetics in our setting, analyze changes over time, describe the clinical and epidemiological features of this allergic reaction, and identify the allergens and cosmetics involved. We performed a prospective study at the skin allergy unit in Hospital General Universitario de Valencia in Spain between 2005 and 2013 and compared our findings with data collected retrospectively for the period 1996 to 2004. The 5419 patients who underwent patch testing during these 2 periods were included in the study. The mean prevalence of ACD to cosmetics increased from 9.8% in the first period (1996-2004) to 13.9% in the second period (2005-2013). A significant correlation was found between ACD to cosmetics and female sex but not atopy. Kathon CG (blend of methylchloroisothiazolinone and methylisothiazolinone), fragrances, and paraphenylenediamine were the most common causes of ACD to cosmetics during both study periods, and acrylates and sunscreens were identified as emerging allergens during the second period.
authors: Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, España. Electronic address: viozaragozaninet@gmail.com.
authors: V
authors: V
authors: Zaragoza-Ninet
authors: Unidad de Control de Gestión, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors: R
authors: R
authors: Blasco Encinas
authors: Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors: J J
authors: JJ
authors: Vilata-Corell
authors: Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors: A
authors: A
authors: Pérez-Ferriols
authors: Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors: C
authors: C
authors: Sierra-Talamantes
authors: Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors: A
authors: A
authors: Esteve-Martínez
authors: Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors: J
authors: J
authors: de la Cuadra-Oyanguren
mesh_terms: D000328:Adult; D003358:Cosmetics / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology*; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D062606:Tertiary Care Centers
chemical_list: D003358:Cosmetics
keywords: Allergic contact dermatitis; Cosmetics; Cosméticos; Dermatitis alérgica de contacto; Fragancias; Fragrances; Kathon CG; Parafenilendiamina; Paraphenylenediamine