title: The usefulness of cardiopulmonary exercise testing in assessment of patients with suspected coronary artery disease.
abstract: OBJECTIVE
  The aim of this study is to assess different parameters of cardiopulmonary exercise testing that can predict the development of myocardial ischaemia in patients with suspected coronary artery disease (CAD) and to identify the parameters which have more correlation with myocardial ischaemia.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  In this study, a total of 31 men (mean age 57.23±11.09 years) with suggestive symptoms of CAD underwent an exercise stress test with breath-by-breath gas exchange analysis, followed by coronary angiography as the gold standard for diagnosing CAD.
  
  
  RESULTS
  The ventilation versus CO2 output (VE/VCO2) peak was significantly different between patients with negative and positive angiography results. Receiver operator characteristic analysis showed an area under the curve of 0.73 for VE/VCO2 peak with diagnostic threshold equal to 35 (95% CI 0.54 to 0.9; p=0.05). Exercise stress testing had sensitivity and specificity of 75% and 40%, respectively.
  
  
  CONCLUSIONS
  A change in ventilatory efficiency assessed using the VE/VCO2 peak has the predictive ability to identify exercise-induced myocardial ischaemia. The present study has provided additional evidence of the potential clinical value of cardiopulmonary exercise testing in the diagnosis of CAD.
authors: Sports Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran Faculty of Medicine, Department of Sports and Exercise Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors: Reza
authors: R
authors: Mazaheri
authors: Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors: Farshad
authors: F
authors: Shakerian
authors: Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Ali
authors: A
authors: Vasheghani-Farahani
authors: Sports Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran Faculty of Medicine, Department of Sports and Exercise Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors: Farzin
authors: F
authors: Halabchi
authors: Sports Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Maryam
authors: M
authors: Mirshahi
authors: Department of Epidemiology & Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mohammad Ali
authors: MA
authors: Mansournia
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis / Q000379:methods; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis; D003430:Cross-Sectional Studies; D005080:Exercise Test / Q000379:methods; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology / Q000517:prevention & control*; D010043:Outcome and Process Assessment, Health Care; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D063189:Symptom Assessment