title: Mitochondrial Cristae: Where Beauty Meets Functionality.
abstract: Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under different physiological conditions. Recent discoveries have unveiled the relation between cristae shape and oxidative phosphorylation (OXPHOS) function, suggesting that membrane morphology modulates the organization and function of the OXPHOS system, with a direct impact on cellular metabolism. As a corollary, cristae-shaping proteins have emerged as potential modulators of mitochondrial bioenergetics, a concept confirmed by genetic experiments in mouse models of respiratory chain deficiency. Here, we review our knowledge of mitochondrial ultrastructural organization and how it impacts mitochondrial metabolism.
authors: Centro Nacional de Investigaciònes Cardiovasculares Carlos III, Madrid, Spain.
authors: Sara
authors: S
authors: Cogliati
authors: Centro Nacional de Investigaciònes Cardiovasculares Carlos III, Madrid, Spain; Departamento de Bioquímica, Universidad Zaragoza, Zaragoza, Spain.
authors: Jose A
authors: JA
authors: Enriquez
authors: Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, Padova, Italy; Department of Biology, University of Padova, Padova, Italy. Electronic address: luca.scorrano@unipd.it.
authors: Luca
authors: L
authors: Scorrano
mesh_terms: D008928:Mitochondria / Q000378:metabolism*; D010085:Oxidative Phosphorylation
keywords: OXPHOS complexes and supercomplexes; cristae; mitochondrial-shaping proteins