title: Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2015.
abstract: The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian provide recommendations for genetic testing and counseling and risk assessment and management for hereditary cancer syndromes. Guidelines focus on syndromes associated with an increased risk of breast and/or ovarian cancer and are intended to assist with clinical and shared decision-making. These NCCN Guidelines Insights summarize major discussion points of the 2015 NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meeting. Major discussion topics this year included multigene testing, risk management recommendations for less common genetic mutations, and salpingectomy for ovarian cancer risk reduction. The panel also discussed revisions to genetic testing criteria that take into account ovarian cancer histology and personal history of pancreatic cancer.
authors: Fox Chase Cancer Center
authors: Mary B
authors: MB
authors: Daly
authors: The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute
authors: Robert
authors: R
authors: Pilarski
authors: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
authors: Jennifer E
authors: JE
authors: Axilbund
authors: St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center
authors: Michael
authors: M
authors: Berry
authors: Huntsman Cancer Institute at the University of Utah
authors: Saundra S
authors: SS
authors: Buys
authors: UCSF Helen Diller Family Comprehensive Cancer Center
authors: Beth
authors: B
authors: Crawford
authors: University of Alabama at Birmingham Comprehensive Cancer Center
authors: Meagan
authors: M
authors: Farmer
authors: FORCE-Facing Our Risk of Cancer Empowered
authors: Susan
authors: S
authors: Friedman
authors: Dana-Farber/Brigham and Women’s Cancer Center
authors: Judy E
authors: JE
authors: Garber
authors: Robert H. Lurie Comprehensive Cancer Center of Northwestern University
authors: Seema
authors: S
authors: Khan
authors: University of Colorado Cancer Center
authors: Catherine
authors: C
authors: Klein
authors: Huntsman Cancer Institute at the University of Utah
authors: Wendy
authors: W
authors: Kohlmann
authors: Stanford Cancer Institute
authors: Allison
authors: A
authors: Kurian
authors: The University of Texas MD Anderson Cancer Center
authors: Jennifer K
authors: JK
authors: Litton
authors: UC San Diego Moores Cancer Center
authors: Lisa
authors: L
authors: Madlensky
authors: Duke Cancer Institute
authors: P Kelly
authors: PK
authors: Marcom
authors: University of Michigan Comprehensive Cancer Center
authors: Sofia D
authors: SD
authors: Merajver
authors: Memorial Sloan Kettering Cancer Center
authors: Kenneth
authors: K
authors: Offit
authors: Moffitt Cancer Center
authors: Tuya
authors: T
authors: Pal
authors: Dana-Farber/Brigham and Women’s Cancer Center
authors: Huma
authors: H
authors: Rana
authors: Fred & Pamela Buffett Cancer Center
authors: Gwen
authors: G
authors: Reiser
authors: Memorial Sloan Kettering Cancer Center
authors: Mark E
authors: ME
authors: Robson
authors: Massachusetts General Hospital Cancer Center
authors: Kristen Mahoney
authors: KM
authors: Shannon
authors: University of Washington Medical Center/Seattle Cancer Care Alliance
authors: Elizabeth
authors: E
authors: Swisher
authors: Roswell Park Cancer Institute
authors: Nicoleta C
authors: NC
authors: Voian
authors: City of Hope Comprehensive Cancer Center
authors: Jeffrey N
authors: JN
authors: Weitzel
authors: Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine
authors: Alison
authors: A
authors: Whelan
authors: Mayo Clinic Cancer Center
authors: Myra J
authors: MJ
authors: Wick
authors: Vanderbilt-Ingram Cancer Center
authors: Georgia L
authors: GL
authors: Wiesner
authors: National Comprehensive Cancer Network
authors: Mary
authors: M
authors: Dwyer
authors: National Comprehensive Cancer Network
authors: Rashmi
authors: R
authors: Kumar
authors: National Comprehensive Cancer Network
authors: Susan
authors: S
authors: Darlow
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D005817:Genetic Counseling / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D009154:Mutation / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors