title: Analysis of delayed TBE-vaccine booster after primary vaccination.
abstract: An open, uncontrolled single centre study was conducted in the Travel Clinic at the Military Hospital, Brussels. Eighty-eight subjects were recruited who had a primary series of tick-borne encephalitis (TBE) vaccine more than 5 years ago and who never received a booster dose afterwards. Response rate after booster vaccination was very high: 84 out of 88 subjects (95.5%) had neutralizing antibodies on plaque reduction neutralization test and all (100%) had IgG antibodies on ELISA, on Day 21-28 after booster vaccination. This study adds valuable information to the common situation of delayed booster interval. The results of our study indicate that in young healthy travellers (<50 years), one booster vaccination after a primary series of TBE vaccine in the past is sufficient to obtain protective antibodies, even if primary vaccination is much longer than the recommended booster interval of 5 years.
authors: Centre for Vaccinology, Ghent University Hospital and Travel Clinic, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium, annelies.aerssens@uzgent.be.
authors: Annelies
authors: A
authors: Aerssens
authors: Research Laboratory for Vector-Borne Diseases, Military Hospital, Brussels, Belgium.
authors: Christel
authors: C
authors: Cochez
authors: Centre for Biological Safety, Robert Koch Institute, Berlin, Germany.
authors: Matthias
authors: M
authors: Niedrig
authors: Research Laboratory for Vector-Borne Diseases, Military Hospital, Brussels, Belgium.
authors: Paul
authors: P
authors: Heyman
authors: Viron/Serion GmbH, Würzburg, Germany and.
authors: Ilona
authors: I
authors: Kühlmann-Rabens
authors: Centre For Infectious Diseases, Military Hospital, Brussels, Belgium and Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
authors: Patrick
authors: P
authors: Soentjens
mesh_terms: D000328:Adult; D001530:Belgium; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006772:Hospitals, Military; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D008887:Military Medicine; D009500:Neutralization Tests; D017063:Outcome Assessment, Health Care; D057236:Travel Medicine; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D014765:Viral Vaccines
keywords: TBE-vaccine; delayed booster