title: Is Patient Age Associated with Perioperative Outcomes After Surgical Resection of Benign Cranial Nerve Neoplasms?
abstract: OBJECTIVE
  Previous studies have demonstrated that increasing age is associated with decreased rates of operative management and gross total resection in patients with vestibular schwannomas.
  
  
  METHODS
  The American College of Surgeons National Surgical Quality Improvement Program data registry was used for this retrospective cohort analysis. Patients enrolled in the registry from 2007 to 2013 with a diagnosis of a benign neoplasm of a cranial nerve were included. The association between age and postoperative morbidity and mortality was evaluated by the use of multivariable logistic regression analyses.
  
  
  RESULTS
  Of 565 patients included for analysis, the mean (median) age was 51 (53) years. Three clusters were evaluated: <50, 50-69, and ≥70 years. Mortality (0% vs. 1.03% vs. 4.55%, P = 0.012), stroke (0% vs. 0.69% vs. 6.82%, P < 0.001), and ventilator weaning failure (0.43% vs. 2.41% vs. 6.82%, P = 0.014) increased with age. Mean age was significantly greater among patients who died (70.60 vs. 50.87 years, P = 0.002) or had a stroke (68.00 vs. 50.89 years, P = 0.006), cardiac arrest (71.50 vs. 50.89 years, P = 0.038), or coma (74.00 vs. 50.96 years, P = 0.020) and those who failed ventilator weaning (62.55 vs. 50.82, P = 0.006). Age as both a continuous (odds ratio 1.10, 95% confidence interval 1.03-1.18) and categorical variable (age 70+ years odds ratio 78.88, 95% confidence interval 3.41-1825.57) was associated with an increased odds of composite morbidity.
  
  
  CONCLUSIONS
  In patients undergoing surgery for benign cranial nerve neoplasms, increasing age is associated with increased mortality, stroke, coma, and ventilator weaning failure. Composite complication rates are significantly greater in patients ≥70 years, with a near 80-fold increased risk of complications.
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors: Brandon A
authors: BA
authors: McCutcheon
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors: Jennifer
authors: J
authors: Grauberger
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors: Meghan
authors: M
authors: Murphy
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors: Panagiotis
authors: P
authors: Kerezoudis
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors: Lorenzo
authors: L
authors: Rinaldo
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors: Daniel
authors: D
authors: Shepherd
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors: Patrick
authors: P
authors: Maloney
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors: Kendall
authors: K
authors: Snyder
authors: Department of Neurologic Surgery, University of California, San Diego, California, USA.
authors: Bob S
authors: BS
authors: Carter
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: Bydon.Mohamad@mayo.edu.
authors: Mohamad
authors: M
authors: Bydon
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors: Jamie J
authors: JJ
authors: Van Gompel
authors: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors: Michael J
authors: MJ
authors: Link
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003390:Cranial Nerve Neoplasms / Q000401:mortality* / Q000601:surgery*; D003391:Cranial Nerves / Q000601:surgery; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000401:mortality; D012372:ROC Curve; D012042:Registries; D012189:Retrospective Studies; D055815:Young Adult
keywords: Acoustic neuroma; Age; Complications; Elderly; National Surgical Quality Improvement Program; Skull base; Vestibular schwannoma