title: Effects of sevoflurane and propofol on S100β and neuron-specific enolase protein levels during cardiopulmonary bypass.
abstract: OBJECTIVE
  Cardiopulmonary bypass (CPB) is associated with the release of S100β and neuron-specific enolase (NSE) indicating cerebral cell injury. The purpose of the present study was to evaluate the effect of propofol and sevoflurane on S100β and NSE levels in patients undergoing coronary artery bypass grafting (CABG).
  
  
  METHODS
  Twenty male patients undergoing CABG were randomly allocated into two groups. One group received sevoflurane (GS) and the other received propofol (GP). Arterial blood samples for analysis of S100β and NSE levels were taken preoperatively (T1), 30 min after initiation of CPB (T2), at the end of CPB (T3), 1 (T4), 6 (T5) and 24 h (T6) postoperatively.
  
  
  RESULTS
  S100β level was significantly higher compared to all analyzed times at T3 in both groups (P < 0.001). S100β level was significantly higher in GP than GS only at T2 (P = 0.002). NSE level was significantly higher at T3, T4 and T5 than T1 in the GP (P = 0.001, 0.002 and 0.023, respectively), while a significant increase was seen at T3 and T4 in GS group (P = 0.001 and 0.047, respectively).
  
  
  CONCLUSIONS
  Our findings showed that both S100β and NSE levels similarly increased during CPB and immediately after CPB during sevoflurane and propofol based anesthesia.
authors: Department of Anesthesiology and Reanimation, Medical Faculty, Sakarya University, Sakarya, Turkey.
authors: A F
authors: AF
authors: Erdem
authors: Y N
authors: YN
authors: Sahin
authors: N
authors: N
authors: Dogan
authors: Z
authors: Z
authors: Umudum
authors: F
authors: F
authors: Bayar
authors: C
authors: C
authors: Bulut
authors: H A
authors: HA
authors: Alici
authors: B
authors: B
authors: Erkut
authors: M
authors: M
authors: Cesur
authors: M
authors: M
authors: Ceviz
mesh_terms: D000368:Aged; D000758:Anesthesia; D018685:Anesthetics, Inhalation; D001930:Brain Injuries; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000097:blood / Q000627:therapeutic use*; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood* / Q000187:drug effects; D015742:Propofol / Q000097:blood / Q000627:therapeutic use*; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood* / Q000187:drug effects; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D064568:S100 Calcium Binding Protein beta Subunit; D000077149:Sevoflurane; D010751:Phosphopyruvate Hydratase; D015742:Propofol