title: Evaluation of oxidative stress status and antioxidant capacity in patients with renal cell carcinoma.
abstract: BACKGROUND
  We evaluated and compared the serum oxidative stress and antioxidant enzymes in patients with renal cell carcinoma (RCC) and the control group.
  
  
  METHODS
  The prospective study consisted of 97 patients with RCC (Group 1) and 80 age and sex matched healthy volunteers (Group 2). Group 1 and 2 were compared concerning serum mean total oxidant status (TOS), total antioxidant capacity (TAC), paraoxonase-1 (PON-1), arylesterase, total thiol, catalase (CAT), myeloperoxidase (MPO) and ceruloplasmin.
  
  
  RESULTS
  Patients' mean age was 58.5 ±12.3 and 56.9 ±15.8 years, respectively, in Group 1 and 2. No statistically significant differences were detected between the groups in terms of oxidative stress parameters and antioxidant capacity measured in the serum of patients including, TOS, TAC, PON1, arylesterase, total thiol, CAT, MPO, and ceruloplasmin levels (p >0.05 for all parameters). The PON-1 value was significantly higher in patients with pT1 stage than pT3 stage (p = 0.007). The arylesterase value was significantly higher in patients with Fuhrman's nuclear grade 3 than grade 2 (p = 0.035). There was no correlation between these parameters level and Fuhrman's nuclear grade, stage, or histopathological tumor type.
  
  
  CONCLUSIONS
  Our results demonstrated that evaluation of these parameters in the serum of patients with localized RCC may not be used as a marker to discriminate between patients with RCC and healthy people.
authors: Ankara Atatürk Training and Research Hospital, Department of Urology, Ankara, Turkey.
authors: Mustafa
authors: M
authors: Aldemir
authors: Karadeniz Technical University, Faculty of Medicine, Department of Urology, Trabzon, Turkey.
authors: Ersagun
authors: E
authors: Karaguzel
authors: Ankara Atatürk Training and Research Hospital, Department of Urology, Ankara, Turkey.
authors: Emrah
authors: E
authors: Okulu
authors: Memorial Ankara Hospital, Department of Urology, Ankara, Turkey.
authors: Ahmet
authors: A
authors: Gudeloglu
authors: Ankara Atatürk Training and Research Hospital, Department of Urology, Ankara, Turkey.
authors: Kemal
authors: K
authors: Ener
authors: Ankara Atatürk Training and Research Hospital, Department of Urology, Ankara, Turkey.
authors: Asim
authors: A
authors: Ozayar
authors: Ankara Atatürk Training and Research Hospital, Department of Urology, Ankara, Turkey.
authors: Ozcan
authors: O
authors: Erel
keywords: antioxidant capacity; oxidative stress; renal cell carcinoma