title: A review of allergoid immunotherapy: is cat allergy a suitable target?
abstract: To modify the course of allergy, different types of specific allergen immunotherapy have been developed such as sublingual immunotherapy and subcutaneous immunotherapy with native allergens or subcutaneous immunotherapy with polymerized allergoids. However, the optimal specific immunotherapy, especially for cat allergy, remains undetermined. Few studies investigating immunotherapy in cat allergy have been published, and the risk of serious adverse reactions and systemic reactions has often been an important issue. Monomeric allergoids have lower allergenic potential while their immunogenicity remains constant, resulting in excellent safety with notable efficacy. Specific immunotherapy with monomeric allergoids could, therefore, be of high value, especially in cat allergy as well as other types of allergy, and bring relief to a great community of patients.
authors: Institute of Medical Statistics, Informatics & Epidemiology (IMSIE), Faculty of Medicine, University of Cologne, Lindenburger Allee 42, 50931 Cologne, Germany.
authors: Nhung T
authors: NT
authors: Nguyen
authors: Institute of Medical Statistics, Informatics & Epidemiology (IMSIE), Faculty of Medicine, University of Cologne, Lindenburger Allee 42, 50931 Cologne, Germany.
authors: Esther
authors: E
authors: Raskopf
authors: Institute of Medical Statistics, Informatics & Epidemiology (IMSIE), Faculty of Medicine, University of Cologne, Lindenburger Allee 42, 50931 Cologne, Germany.
authors: Kija
authors: K
authors: Shah-Hosseini
authors: Institute of Medical Statistics, Informatics & Epidemiology (IMSIE), Faculty of Medicine, University of Cologne, Lindenburger Allee 42, 50931 Cologne, Germany.
authors: Gregor
authors: G
authors: Zadoyan
authors: Institute of Medical Statistics, Informatics & Epidemiology (IMSIE), Faculty of Medicine, University of Cologne, Lindenburger Allee 42, 50931 Cologne, Germany.
authors: Ralph
authors: R
authors: Mösges
mesh_terms: D000485:Allergens / Q000737:chemistry / Q000627:therapeutic use*; D000080384:Allergoids; D000818:Animals; D002415:Cats / Q000276:immunology; D003888:Desensitization, Immunologic / Q000379:methods*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*; D007279:Injections, Subcutaneous; D010936:Plant Extracts / Q000627:therapeutic use; D058105:Polymerization; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use*; D012306:Risk; D063729:Sublingual Immunotherapy
chemical_list: D000485:Allergens; D000080384:Allergoids; D010936:Plant Extracts; D011108:Polymers
keywords: SLIT; allergoid; asthma; cat allergy; cat sensitization; rhinitis; specific immunotherapy