title: Prognostic Value of Semiautomatic CT Volumetry in Patients With Stage I Non-Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy.
abstract: OBJECTIVE
  The aim of this study was to examine the prognostic value of semiautomated 3-dimensional image analysis-based parameters from pretreatment computed tomography (CT) in patients with non-small cell lung cancer treated with stereotactic body radiation therapy.
  
  
  METHODS
  We evaluated 91 patients. We defined 2 parameters: (1) VOL, extracted tumor volume with a threshold ≥ -400 HU; and (2) ATN, the mean CT attenuation value. The maximum standardized uptake value (SUVmax) was recorded as F-fluorodeoxyglucose positron emission tomography/CT parameter. The prognostic values were assessed using the Kaplan-Meier and a Cox proportional hazards analysis.
  
  
  RESULTS
  Overall survival and progression-free survival were significantly worse in patients with larger VOL, higher ATN, and higher SUVmax. VOL was an independent indicator of overall survival, whereas ATN was an indicator of progression-free survival, lymph node recurrence, and distant metastasis. However, SUVmax was not an independent prognostic factor for either outcome.
  
  
  CONCLUSIONS
  VOL and ATN from 3-dimensional image analysis of CT scans have prognostic values for non-small cell lung cancer patients treated with stereotactic body radiation therapy.
authors: From the *PET Center, Kofu Neurosurgical Hospital; †Department of Radiology, University of Yamanashi, Yamanashi; and ‡Department of Radiology, Teikyo University School of Medicine University Hospital, Mizonokuchi, Kawasaki City, Kanagawa Prefecture, Japan.
authors: Yoko
authors: Y
authors: Satoh
authors: Utaroh
authors: U
authors: Motosugi
authors: Atsushi
authors: A
authors: Nambu
authors: Akitoshi
authors: A
authors: Saito
authors: Hiroshi
authors: H
authors: Onishi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000401:mortality / Q000532:radiotherapy*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000706:statistics & numerical data; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000401:mortality / Q000517:prevention & control; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis; D016634:Radiosurgery / Q000401:mortality*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D047368:Tumor Burden