title: Superfertility is more prevalent in obese women with recurrent early pregnancy miscarriage.
abstract: OBJECTIVE
  To investigate the effects of obesity on superfertility.
  
  
  METHODS
  Retrospective observational study.
  
  
  METHODS
  A tertiary referral implantation clinic.
  
  
  METHODS
  Four hundred and fourteen women attending a tertiary implantation clinic with a history of recurrent miscarriage (RMC), over a 4-year period.
  
  
  METHODS
  Pattern of pregnancy loss and time to pregnancy intervals for each pregnancy were collected by medical staff from women with RMC. The women were categorised into normal, overweight and obese according to their body mass index (BMI). Kaplan-Meier curves were constructed estimating the cumulative probability of a spontaneous pregnancy over time. The pregnancy loss patterns were correlated with BMI and data were compared between the categories using the Kruskal-Wallis test.
  
  
  METHODS
  Pregnancy loss pattern and time to pregnancy intervals.
  
  
  RESULTS
  Overall, 23.2, 51.4 and 64.2% of women conceived within first 1, 3 and 6 months, respectively. Obese women had cumulative pregnancy rates of 65.2 and 80% by three and 6 months, respectively, which was more than the cumulative pregnancy rates for women with normal BMI (49.2 and 65.8%). Comparison of survival curves indicated a significant difference in time to conceive for obese when compared with normal and overweight women (*P = 0.01), suggesting a higher prevalence of superfertility in obese women with RMC.
  
  
  CONCLUSIONS
  Our findings suggest that obese women may have a greater efficacy to achieve pregnancy, but with an increased risk of miscarriage, which may suggest the possible metabolic effects of obesity on endometrium.
authors: Division of Reproductive Health, Clinical Science Research Laboratories, Warwick Medical School, University of Warwick, Coventry, UK.|Department of Obstetrics and Gynaecology, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK.
authors: H M
authors: HM
authors: Bhandari
authors: Division of Reproductive Health, Clinical Science Research Laboratories, Warwick Medical School, University of Warwick, Coventry, UK.|Department of Obstetrics and Gynaecology, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, UK.
authors: B K
authors: BK
authors: Tan
authors: Division of Reproductive Health, Clinical Science Research Laboratories, Warwick Medical School, University of Warwick, Coventry, UK.|Department of Obstetrics and Gynaecology, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK.
authors: S
authors: S
authors: Quenby
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D000328:Adult; D015992:Body Mass Index; D005260:Female; D005298:Fertility; D006801:Humans; D008423:Maternal Age; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D011247:Pregnancy; D015995:Prevalence; D034121:Reproductive Health Services; D012189:Retrospective Studies; D018570:Risk Assessment; D006113:United Kingdom / Q000453:epidemiology
keywords: Obesity; recurrent miscarriage; superfertility