title: Association of Serum hs-CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors.
abstract: BACKGROUND
  Diabetes mellitus remains one of the major health problems of the 21st century and is associated with comorbidities including obesity and metabolic abnormalities. The study was conducted to evaluate serum high-sensitivity C-reactive protein (hs-CRP) levels, as a marker of inflammation, in a large sample of Iranian population without a history of cardiovascular or inflammatory disease and cancer, and to relate this to fasting blood glucose (FBG) and the presence of diabetes mellitus.
  
  
  METHODS
  The study consisted of 7,762 subjects divided into four groups-nonobese/nondiabetic, obese/nondiabetic, nonobese/diabetic and obese/diabetic-based on the BMI classification and their FBG. Anthropometric characteristics were measured and blood was collected for the evaluation of fasted lipid profile, FBG and serum hs-CRP levels.
  
  
  RESULTS
  Several clinical and biochemical characteristics were significantly different among the four groups: FBG, P < 0.001; total cholesterol (TC), P < 0.001; and triglyceride (TG), P < 0.001. The subjects with a serum hs-CRP >3 mg/dl had higher TC (P < 0.001), low-density lipoprotein cholesterol (LDL-C, P < 0.001), TG (P < 0.001), fat percentage (P < 0.001), and systolic and diastolic blood pressure (P < 0.001) compared with subjects with a serum hs-CRP <3 mg/dl. Multivariate analysis showed FBG, LDL-C, and waist circumference (WC) associated with increased serum hs-CRP levels (P < 0.001).
  
  
  CONCLUSIONS
  FBG, LDL-C, WC and gender are independently associated with serum hs-CRP concentrations.
authors: Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Mahmoud
authors: M
authors: Ebrahimi
authors: Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Ali Reza
authors: AR
authors: Heidari-Bakavoli
authors: Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Sara
authors: S
authors: Shoeibi
authors: Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
authors: Seyed Reza
authors: SR
authors: Mirhafez
authors: Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Mohsen
authors: M
authors: Moohebati
authors: Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Habibollah
authors: H
authors: Esmaily
authors: Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Hamed
authors: H
authors: Ghazavi
authors: Student Research Committee, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Maryam
authors: M
authors: Saberi Karimian
authors: Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Seyed Mohammad Reza
authors: SM
authors: Parizadeh
authors: Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Maryam
authors: M
authors: Mohammadi
authors: Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Hossein
authors: H
authors: Mohaddes Ardabili
authors: Division of Medical Education, Brighton & Sussex Medical School, Brighton, Sussex, UK.
authors: Gordon A
authors: GA
authors: Ferns
authors: Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ghayourm@mums.ac.ir.|Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ghayourm@mums.ac.ir.
authors: Majid
authors: M
authors: Ghayour-Mobarhan
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications*; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein
keywords: anthropometric characteristics; diabetes; high-sensitivity C-reactive protein (hs-CRP); obesity