title: Mapping health assessment questionnaire disability index (HAQ-DI) score, pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) onto the EuroQol-5D (EQ-5D) utility score with the KORean Observational study Network for Arthritis (KORONA) registry data.
abstract: The aim of this study was to estimate the mapping model for EuroQol-5D (EQ-5D) utility values using the health assessment questionnaire disability index (HAQ-DI), pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) in a large, nationwide cohort of rheumatoid arthritis (RA) patients in Korea. The KORean Observational study Network for Arthritis (KORONA) registry data on 3557 patients with RA were used. Data were randomly divided into a modeling set (80 % of the data) and a validation set (20 % of the data). The ordinary least squares (OLS), Tobit, and two-part model methods were employed to construct a model to map to the EQ-5D index. Using a combination of HAQ-DI, pain VAS, and DAS28, four model versions were examined. To evaluate the predictive accuracy of the models, the root-mean-square error (RMSE) and mean absolute error (MAE) were calculated using the validation dataset. A model that included HAQ-DI, pain VAS, and DAS28 produced the highest adjusted R (2) as well as the lowest Akaike information criterion, RMSE, and MAE, regardless of the statistical methods used in modeling set. The mapping equation of the OLS method is given as EQ-5D = 0.95-0.21 × HAQ-DI-0.24 × pain VAS/100-0.01 × DAS28 (adjusted R (2) = 57.6 %, RMSE = 0.1654 and MAE = 0.1222). Also in the validation set, the RMSE and MAE were shown to be the smallest. The model with HAQ-DI, pain VAS, and DAS28 showed the best performance, and this mapping model enabled the estimation of an EQ-5D value for RA patients in whom utility values have not been measured.
authors: School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-Gu, Suwon, Gyeonggi-do, 440-746, Republic of Korea.|College of Pharmacy, Sahmyook University, Seoul, Republic of Korea.
authors: Hye-Lin
authors: HL
authors: Kim
authors: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, 133-792, Republic of Korea.|Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, Republic of Korea.
authors: Dam
authors: D
authors: Kim
authors: Department of Information Statistics, Andong National University, Andong, Republic of Korea.
authors: Eun Jin
authors: EJ
authors: Jang
authors: School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-Gu, Suwon, Gyeonggi-do, 440-746, Republic of Korea.
authors: Min-Young
authors: MY
authors: Lee
authors: School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-Gu, Suwon, Gyeonggi-do, 440-746, Republic of Korea.
authors: Hyun Jin
authors: HJ
authors: Song
authors: School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-Gu, Suwon, Gyeonggi-do, 440-746, Republic of Korea.
authors: Sun-Young
authors: SY
authors: Park
authors: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, 133-792, Republic of Korea.|Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, Republic of Korea.
authors: Soo-Kyung
authors: SK
authors: Cho
authors: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, 133-792, Republic of Korea.|Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, Republic of Korea.
authors: Yoon-Kyoung
authors: YK
authors: Sung
authors: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, 133-792, Republic of Korea.|Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, Republic of Korea.
authors: Chan-Bum
authors: CB
authors: Choi
authors: Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, Republic of Korea.
authors: Soyoung
authors: S
authors: Won
authors: Hanyang University Guri Hospital, Guri, Republic of Korea.
authors: So-Young
authors: SY
authors: Bang
authors: Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Hoon-Suk
authors: HS
authors: Cha
authors: Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
authors: Jung-Yoon
authors: JY
authors: Choe
authors: Dong-A University Hospital, Busan, Republic of Korea.
authors: Won Tae
authors: WT
authors: Chung
authors: Kyung Hee University Hospital, Seoul, Republic of Korea.
authors: Seung-Jae
authors: SJ
authors: Hong
authors: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, 133-792, Republic of Korea.
authors: Jae-Bum
authors: JB
authors: Jun
authors: Jeju National University Hospital, Jeju, Republic of Korea.
authors: Jinseok
authors: J
authors: Kim
authors: Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
authors: Seong-Kyu
authors: SK
authors: Kim
authors: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, 133-792, Republic of Korea.
authors: Tae-Hwan
authors: TH
authors: Kim
authors: Chonnam National University Hospital, Gwangju, Republic of Korea.
authors: Tae-Jong
authors: TJ
authors: Kim
authors: Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Eunmi
authors: E
authors: Koh
authors: Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
authors: Hwajeong
authors: H
authors: Lee
authors: Hanyang University Guri Hospital, Guri, Republic of Korea.
authors: Hye-Soon
authors: HS
authors: Lee
authors: Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea.
authors: Jisoo
authors: J
authors: Lee
authors: Chonnam National University Hospital, Gwangju, Republic of Korea.
authors: Shin-Seok
authors: SS
authors: Lee
authors: Dong-A University Hospital, Busan, Republic of Korea.
authors: Sung Won
authors: SW
authors: Lee
authors: Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
authors: Sung-Hoon
authors: SH
authors: Park
authors: Chungnam National University Hospital, Daejeon, Republic of Korea.
authors: Seung-Cheol
authors: SC
authors: Shim
authors: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, 133-792, Republic of Korea.
authors: Dae-Hyun
authors: DH
authors: Yoo
authors: Inje University Ilsan Paik Hospital, Goyang, Republic of Korea.
authors: Bo Young
authors: BY
authors: Yoon
authors: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, 133-792, Republic of Korea. scbae@hanyang.ac.kr.|Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, Republic of Korea. scbae@hanyang.ac.kr.
authors: Sang-Cheol
authors: SC
authors: Bae
authors: School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-Gu, Suwon, Gyeonggi-do, 440-746, Republic of Korea. ekyung@skku.edu.
authors: Eui-Kyung
authors: http://orcid.org/0000-0003-0601-7754
authors: EK
authors: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000191:economics / Q000503:physiopathology / Q000628:therapy; D003362:Cost-Benefit Analysis; D004185:Disability Evaluation; D005260:Female; D017048:Health Care Costs; D006295:Health Resources / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D016018:Least-Squares Analysis; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018803:Models, Economic; D010147:Pain Measurement; D011237:Predictive Value of Tests; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012042:Registries; D015203:Reproducibility of Results; D056910:Republic of Korea / Q000453:epidemiology; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: DAS28; EQ-5D; HAQ-DI; Mapping; Utility