title: Thyroid hormone therapy and procurement of livers from brain-dead donors.
abstract: Hormonal therapy to brain-dead potential organ donors remains controversial. A retrospective study was carried out of hormonal therapy on procurement of organs in 63,593 donors in whom information on T3/T4 therapy was available. In 40,124 donors, T3/T4 and all other hormonal therapy was recorded. The percentages of all organs procured, except livers, were greater in T3/T4-treated donors. Nevertheless, if T3/T4 therapy had been administered to the donor, liver transplantation was associated with significantly increased graft and recipient survival at 1 month and 12 months. The potential reasons for the lack of effect of T3/T4 therapy on the number of livers procured are discussed.
authors: a Formerly Professor of Cardiothoracic Surgery , University of South Florida , Tampa , FL , USA.
authors: Dimitri
authors: D
authors: Novitzky
authors: b Cooperative Studies Program Coordinating Center, VA Medical Center , Perry Point , MD , USA.
authors: Zhibao
authors: Z
authors: Mi
authors: c Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences , Faculty of Medicine, University of Chile , Santiago , Chile.
authors: Luis A
authors: LA
authors: Videla
authors: b Cooperative Studies Program Coordinating Center, VA Medical Center , Perry Point , MD , USA.
authors: Joseph F
authors: JF
authors: Collins
authors: d Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center , Pittsburgh , PA , USA.
authors: David K C
authors: DK
authors: Cooper
mesh_terms: D001926:Brain Death / Q000378:metabolism*; D020249:Hormone Replacement Therapy; D006801:Humans; D016031:Liver Transplantation; D012189:Retrospective Studies; D013963:Thyroid Hormones / Q000008:administration & dosage / Q000378:metabolism*; D009927:Tissue and Organ Procurement
chemical_list: D013963:Thyroid Hormones
keywords: Anti-diuretic hormone; brain death; insulin; levothyroxine; organ donors; triiodothyronine