title: Prostate Cancer Stem Cells: Viewing Signaling Cascades at a Finer Resolution.
abstract: It is becoming characteristically more understandable that within tumor cells, there lies a sub-population of tumor cells with "stem cell" like properties and remarkable ability of self-renewal. Many features of these self-renewing cells are comparable with normal stem cells and are termed as "cancer stem cells". Accumulating experimentally verified data has started to scratch the surface of spatio-temporally dysregulated intracellular signaling cascades in the biology of prostate cancer stem cells. We partition this multicomponent review into how different signaling cascades operate in cancer stem cells and how bioactive ingredients isolated from natural sources may modulate signaling network.
authors: Department of Pharmacology, Capital Medical University, Beijing, People's Republic of China.
authors: Xiukun
authors: X
authors: Lin
authors: Laboratory for Translational Oncology and Personalized Medicine, RLMC, 35 Km Ferozepur Road, Lahore, Pakistan. ammadahmad638@yahoo.com.
authors: Ammad Ahmad
authors: AA
authors: Farooqi
authors: Department of Chemistry, GCU, Lahore, Pakistan.
authors: Muhammad Zahid
authors: MZ
authors: Qureshi
authors: Laboratorio de Investigación Clínica, Unidad Académica de Medicina, Universidad Autónoma de Guerrero, Av. Solidaridad S/N Col. Hornos Insurgentes, Acapulco, Guerrero, México.
authors: Mirna Azalea
authors: MA
authors: Romero
authors: Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan.
authors: Sobia
authors: S
authors: Tabassum
authors: Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.
authors: Muhammad
authors: M
authors: Ismail
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000166:cytology*; D010641:Phenotype; D011471:Prostatic Neoplasms / Q000378:metabolism*; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D053823:Hedgehog Proteins; D035683:MicroRNAs; D016212:Transforming Growth Factor beta; D051153:Wnt Proteins
keywords: Apoptosis; Intracellular signaling; Molecular therapeutics; Prostate cancer stem cells