title: Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial.
abstract: The study was designed to determine the effect of thirty days of pomegranate extract oral supplementation on plasma inflammatory and oxidative stress biomarkers as well as serum metabolic profiles, in overweight and obese individuals. In this randomized, double-blind, placebo-controlled study 48 obese and overweight participants were randomly assigned to receive either 1000 mg of pomegranate extract, or a placebo, daily for 30 days. At baseline, and after 30 days of treatment, anthropometric parameters, dietary intake, plasma concentrations of malondialdehyde, interleukin-6 and hyper sensitive-C reactive protein and levels of serum lipids, glucose and insulin were assessed. Thirty days of PE supplementation resulted in a significant decrease in mean serum levels of glucose, insulin, total cholesterol, LDL-C, and plasma MDA, IL-6 and hs-CRP. HDL-C significantly increased following the PE versus the PL intervention. Our study suggests that pomegranate extract consumption may reduce complications linked with obesity.
authors: Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
authors: Banafshe
authors: B
authors: Hosseini
authors: Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; School of Medicine, Western Sydney University, NSW, Australia. Electronic address: A.Saedisomeolia@westernsydney.edu.au.
authors: Ahmad
authors: A
authors: Saedisomeolia
authors: School of Biomedical Science and Pharmacy, University of Newcastle, NSW, Australia. Electronic address: lisa.wood@newcastle.edu.au.
authors: Lisa G
authors: LG
authors: Wood
authors: Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mehdi
authors: M
authors: Yaseri
authors: Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Sanaz
authors: S
authors: Tavasoli
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000975:Antioxidants / Q000032:analysis; D004032:Diet; D019587:Dietary Supplements; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy*; D029561:Lythraceae; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts
keywords: Inflammation; Lipid peroxidation; Obesity; Polyphenols; Pomegranate extract