title: [Characteristics of subgroups classified by pulmonary function test in chronic obstructive pulmonary disease patients].
abstract: OBJECTIVE
  To compare the clinical characteristics and the therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classified by diffusing capacity of the lung for carbon monoxide (D(L)CO) and inspiratary capacity (IC).
  
  
  METHODS
  A total of 105 mild-severe patients (70 males, 35 females, 44 to 85 years of age), with stable COPD were recruited in Cangzhou Central Hospital from June 2012 to June 2014. According to baseline D(L)CO and IC, the patients were divided into normal D(L)CO/IC group (group A, n=10), low D(L)CO/normal IC group (group B, n=18), normal D(L)CO/low IC group (group C, n=22) and low D(L)CO/IC group (group D, n=55). We compared the clinical characteristics, induced sputum cells and the therapeutic responses to 3-month treatment of budesonide/formoterol(320 µg/9 µg, inhale, bid)among the 4 groups.
  
  
  RESULTS
  Group D showed the highest CAT scores(27.6 ± 6.4). Group C showed a higher prevalence of patients with wheezing(81.8)% and the highest percentage of sputum eosinophils (7.6 ± 3.2)%. Group C showed the greatest FEV(1) increase(0.214 ± 0.053)L. Group D showed a greater FEV(1) increase than Group B [(0.137 ± 0.063) vs (0.092 ± 0.048)L]. Group C showed a greater FVC[(0.342 ± 0.073), (0.190 ± 0.081), (0.223 ± 0.094)L] increase and CAT[(4.4 ± 2.0), (2.3 ± 1.3), (3.9 ± 1.9)] decrease than Group B and Group D(P<0.05).
  
  
  CONCLUSIONS
  These findings suggest that COPD subgroups classified by D(L)CO and IC show several clinical characteristics and may be helpful to predict responses to treatment.
authors: The First Department of Respiratory Medicine, Cangzhou Central Hospital, Cangzhou 061000, China.
authors: Xiaosheng
authors: X
authors: Wang
authors: The First Department of Respiratory Medicine, Cangzhou Central Hospital, Cangzhou 061000, China.
authors: Min
authors: M
authors: Li
authors: The First Department of Respiratory Medicine, Cangzhou Central Hospital, Cangzhou 061000, China.
authors: Xiaoling
authors: X
authors: Kang
authors: The First Department of Respiratory Medicine, Cangzhou Central Hospital, Cangzhou 061000, China.
authors: Lirong
authors: L
authors: Zhou
authors: The First Department of Respiratory Medicine, Cangzhou Central Hospital, Cangzhou 061000, China.
authors: Jing
authors: J
authors: Lyu
authors: The First Department of Respiratory Medicine, Cangzhou Central Hospital, Cangzhou 061000, China.
authors: Baohua
authors: B
authors: Sun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019819:Budesonide; D004804:Eosinophils; D004983:Ethanolamines; D005260:Female; D000068759:Formoterol Fumarate; D006801:Humans; D008168:Lung; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive; D012129:Respiratory Function Tests; D013183:Sputum
chemical_list: D004983:Ethanolamines; D019819:Budesonide; D000068759:Formoterol Fumarate