title: Brief Report: HIV Drug Resistance in Adults Failing Early Antiretroviral Treatment: Results From the HIV Prevention Trials Network 052 Trial.
abstract: Early initiation of antiretroviral treatment (ART) reduces HIV transmission and has health benefits. HIV drug resistance can limit treatment options and compromise use of ART for HIV prevention. We evaluated drug resistance in 85 participants in the HIV Prevention Trials Network 052 trial who started ART at CD4 counts of 350-550 cells per cubic millimeter and failed ART by May 2011; 8.2% had baseline resistance and 35.3% had resistance at ART failure. High baseline viral load and less education were associated with emergence of resistance at ART failure. Resistance at ART failure was observed in 7 of 8 (87.5%) participants who started ART at lower CD4 cell counts.
authors: 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; 2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 3Frontier Science & Technology Research Foundation, Amherst, NY; 4Specialty Molecular Division, Lancet Laboratories and BARC-SA, Johannesburg, South Africa; 5Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil; 6Y. R. Gaitonde Centre for AIDS Research and Education, Chennai, India; 7National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, India; 8Science Facilitation Department, FHI 360, Washington, DC; 9Science Facilitation Department, FHI 360, Durham, NC; 10Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; 11Southwest CARE Center, Santa Fe, NM; 12College of Medicine-Johns Hopkins Project, Blantyre, Malawi; 13Botswana Harvard AIDS Institute, Gaborone, Botswana; 14YRGCARE Medical Centre, VHS, Chennai, India; 15Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; 16Department of Medicine, University of Zimbabwe, Harare, Zimbabwe; 17Wits Reproductive Health and HIV Institute, University of Witwatersrand, Johannesburg, South Africa; 18Kenya Medical Research Institute, Center for Disease Control, Kisumu, Kenya; 19Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC; 20UNC Project-Malawi, Institute for Global Health and Infectious Diseases, Lilongwe, Malawi; 21Serviço de Infectologia, Hospital Nossa Senhora da Conceição, Porto Alegre, Brazil; 22Department of Epidemiology and Biostatistics, National AIDS Research Institute (ICMR), Pune, India; 23Hospital Geral de Nova Iguacu and Laboratorio de AIDS e Imunologia Molecular-IOC/Fiocruz, Rio de Janeiro, Brazil; 24Instituto Nacional de Infectologia Evandro Chagas-INI-Fiocruz, Rio de Janeiro, Brazil; 25Perinatal HIV Research Unit, University of the Witwatersrand, Soweto HPTN CRS, S
authors: Jessica M
authors: JM
authors: Fogel
authors: Sarah E
authors: SE
authors: Hudelson
authors: San-San
authors: SS
authors: Ou
authors: Stephen
authors: S
authors: Hart
authors: Carole
authors: C
authors: Wallis
authors: Mariza G
authors: MG
authors: Morgado
authors: Shanmugam
authors: S
authors: Saravanan
authors: Srikanth
authors: S
authors: Tripathy
authors: Laura
authors: L
authors: Hovind
authors: Estelle
authors: E
authors: Piwowar-Manning
authors: Devin
authors: D
authors: Sabin
authors: Marybeth
authors: M
authors: McCauley
authors: Theresa
authors: T
authors: Gamble
authors: Xinyi C
authors: XC
authors: Zhang
authors: Joseph J
authors: JJ
authors: Eron
authors: Joel E
authors: JE
authors: Gallant
authors: Johnstone
authors: J
authors: Kumwenda
authors: Joseph
authors: J
authors: Makhema
authors: Nagalingeswaran
authors: N
authors: Kumarasamy
authors: Suwat
authors: S
authors: Chariyalertsak
authors: James
authors: J
authors: Hakim
authors: Sharlaa
authors: S
authors: Badal-Faesen
authors: Victor
authors: V
authors: Akelo
authors: Mina C
authors: MC
authors: Hosseinipour
authors: Breno R
authors: BR
authors: Santos
authors: Sheela V
authors: SV
authors: Godbole
authors: Jose H
authors: JH
authors: Pilotto
authors: Beatriz
authors: B
authors: Grinsztejn
authors: Ravindre
authors: R
authors: Panchia
authors: Kenneth H
authors: KH
authors: Mayer
authors: Ying Q
authors: YQ
authors: Chen
authors: Myron S
authors: MS
authors: Cohen
authors: Susan H
authors: SH
authors: Eshleman
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D004334:Drug Administration Schedule; D024882:Drug Resistance, Viral / Q000187:drug effects*; D005260:Female; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology*; D006801:Humans; D008297:Male; D064887:Observational Studies as Topic; D017211:Treatment Failure; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents