title: γ-Lactam alkaloids from the flower buds of daylily.
abstract: Four new alkaloids, hemerocallisamines IV-VII, were isolated from the methanol extract of flower buds of daylily. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The absolute stereochemistry of the hemerocallisamines IV-VI was elucidated by the application of the modified Mosher's method, HPLC analysis, and optical rotation. In the present study, the isolated alkaloids significantly inhibited the aggregation of Aβ42 in vitro. This is the first report about bioactive alkaloids with a γ-lactam ring from daylily. In addition, isolated nucleosides showed accelerative effects on neurite outgrowth under the non-fasting condition.
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors: Takahiro
authors: T
authors: Matsumoto
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors: Seikou
authors: S
authors: Nakamura
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors: Souichi
authors: S
authors: Nakashima
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors: Tomoe
authors: T
authors: Ohta
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors: Mamiko
authors: M
authors: Yano
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors: Junichiro
authors: J
authors: Tsujihata
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors: Junko
authors: J
authors: Tsukioka
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors: Keiko
authors: K
authors: Ogawa
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors: Masashi
authors: M
authors: Fukaya
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors: Masayuki
authors: M
authors: Yoshikawa
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan. matsuda@mb.kyoto-phu.ac.jp.
authors: Hisashi
authors: H
authors: Matsuda
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000544:Alzheimer Disease; D000818:Animals; D035264:Flowers / Q000737:chemistry*; D031421:Hemerocallis / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D016716:PC12 Cells; D051381:Rats
chemical_list: D000470:Alkaloids; D007769:Lactams
keywords: Alkaloids; Alzheimer’s diseases; Aβ42 aggregation; Daylily; PC12 cell