title: Sorazolons, Carbazole Alkaloids from Sorangium cellulosum Strain Soce375.
abstract: Sorazolons A (1) to E2 (9) were isolated from Sorangium cellulosum strain Soce375. Their molecular structures were elucidated using extensive HRESIMS and NMR analysis. The absolute configuration of sorazolon A (1) was determined by comparison of the experimental CD spectrum with quantum chemical calculated spectra for both enantiomers. Sorazolons D2 (7), E (8), and E2 (9) exhibit a moderate cytotoxic activity against mouse fibroblast cell line L929 with IC50 values between 5.0 μM and 0.09 mM.
authors: Department of Microbial Drugs, Helmholtz Centre for Infection Research , Inhoffenstraße 7, 38124 Braunschweig, Germany.|German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig , Braunschweig, Germany.
authors: Sabrina
authors: S
authors: Karwehl
authors: Department of Microbial Drugs, Helmholtz Centre for Infection Research , Inhoffenstraße 7, 38124 Braunschweig, Germany.|German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig , Braunschweig, Germany.
authors: Rolf
authors: R
authors: Jansen
authors: Department of Inorganic Chemistry, Saarland University , Building C 4.1, 66123 Saarbrücken, Germany.
authors: Volker
authors: V
authors: Huch
authors: Department of Microbial Drugs, Helmholtz Centre for Infection Research , Inhoffenstraße 7, 38124 Braunschweig, Germany.|German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig , Braunschweig, Germany.
authors: Marc
authors: M
authors: Stadler
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002227:Carbazoles; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects; D020102:Mycobacterium smegmatis / Q000187:drug effects; D009231:Myxococcales / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D002227:Carbazoles; C000608915:sorazolon A; C000608917:sorazolon E; C000608916:sorazolon E2