title: The Prevalence and Genotype Distribution of Human Papillomavirus in the Genital Tract of Males in Iran.
abstract: BACKGROUND
  Human papillomavirus (HPV) is the most common viral sexually-transmitted infection. Despite HPV infection is associated with several malignant disorders including penile and anal cancers, little is known about the epidemiology of HPV infection in males, particularly in developing countries.
  
  
  OBJECTIVE
  The aim of this study was to determine the prevalence of HPV infection and its genotype distribution among Iranian males.
  
  
  METHODS
  Between March 2009 and April 2014, a total number of 483 males, referred to Iran University of Medical Sciences-affiliated sexually transmitted infections (STI) clinics, were enrolled in this study. Following DNA extraction, HPV detection and genotyping were performed using INNO-LiPA HPV Genotyping Extra assay. To analyze the association of HPV infection and age, the logistic regression was employed.
  
  
  RESULTS
  No statistical association between HPV infection and age was observed (P = 0.469). Furthermore, there was no statistically significant correlation between HR HPV infection and age (P = 0.330).
  
  
  CONCLUSIONS
  In this investigation, the prevalence of HPV infection was relatively substantial. Totally, 17 different HPV genotypes were detected and the most frequently detected genotypes were HPV6, HPV11, HPV16, HPV18 and HPV52, respectively. The data from this study is essential for planning future public health strategies including HPV vaccination programs.
authors: Department of Virology, Institute Pasteur of Iran, Tehran, IR Iran; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran.
authors: Mostafa
authors: M
authors: Salehi-Vaziri
authors: Department of Microbiology, School of Medicine, Babol University of Medical Sciences, Babol, IR Iran.
authors: Farzin
authors: F
authors: Sadeghi
authors: Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, IR Iran.
authors: Farah
authors: F
authors: Bokharaei-Salim
authors: Department of Clinical Laboratory Sciences, Nilou Medical Laboratory, Tehran, IR Iran.
authors: Sarang
authors: S
authors: Younesi
authors: Department of Cellular and Molecular Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, IR Iran.
authors: Samaneh
authors: S
authors: Alinaghi
authors: Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, IR Iran.
authors: Seyed Hamidreza
authors: SH
authors: Monavari
authors: Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, IR Iran.
authors: Hossein
authors: H
authors: Keyvani
keywords: Genotype; Human Papillomavirus; Infection