title: Hyperglycemia and its association with clinical outcomes in postsurgical neonates and small infants in the intensive care unit.
abstract: OBJECTIVE
  The aim of the research was to investigate the association between postsurgical hyperglycemia of neonates and small infants (<6months) during their stays in intensive care unit and clinical outcomes.
  
  
  METHODS
  A retrospective study of 180 patients including neonates and small infants (<6months) admitted to pediatric intensive care unit (PICU) after major abdominal and thoracic surgeries from July 2012 to December 2014 was performed. Clinical data including serum glucose levels, surgical procedures, PICU length of stays, total length of hospital stays, systemic infections and wound infections were recorded and analyzed. Surgical diagnosis and Pediatric Risk of Mortality III (PRISM III) score were analyzed as confounding factors.
  
  
  RESULTS
  Maximum glucose values (Gmax) ranged from 4.8 to 32.9mmol/L (median level: 8.4mmol/L). Hyperglycemia was prevalent among this group of patients. 93.3% of them experienced hyperglycemia (>6.1mmol/L) and 20% had severe hyperglycemia (>11.0mmol/L). Both PICU length of stays and total hospital length of stays increased as Gmax increased (P<0.001). This trend was still statistically significant when either surgical diagnosis or PRISM score had been controlled as confounding factors. Death rates and infectious rates were not significantly different among four groups of patients with different Gmax.
  
  
  CONCLUSIONS
  Hyperglycemia was prevalent in postsurgical neonates and small infants in PICU and was associated with increased PICU and hospital stays.
authors: Department of Pediatric Surgery, West China Hospital, Sichuan University, China.
authors: Yang
authors: Y
authors: Wu
authors: Department of Pediatric Intensive Care Unit, West China Hospital, Sichuan University, China.
authors: Wei
authors: W
authors: Lai
authors: Department of Medical Statistics,West China School of Public Health, Sichuan University, China.
authors: Jiao
authors: J
authors: Pei
authors: Department of Pediatric Surgery, West China Hospital, Sichuan University, China.
authors: Yiyang
authors: Y
authors: Zhao
authors: Department of Pediatric Surgery, West China Hospital, Sichuan University, China.
authors: Qi
authors: Q
authors: Wang
authors: Department of Pediatric Surgery, West China Hospital, Sichuan University, China. Electronic address: xb_scu.edu@hotmail.com.
authors: Bo
authors: B
authors: Xiang
mesh_terms: D000005:Abdomen / Q000601:surgery; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D017063:Outcome Assessment, Health Care; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology; D015996:Survival Rate; D019616:Thoracic Surgical Procedures
keywords: Hyperglycemia; Infants; Neonates; Picu; Surgery