title: Association of Adipokines, Insulin Resistance, Hypertension and Dyslipidemia in Patients with Psoriasis Vulgaris.
abstract: BACKGROUND
  Systemic inflammation in psoriasis causes insulin resistance and cardiovascular diseases. Adipokines are adipose-tissue-derived factors that are involved in metabolic processes. It is thought that these adipokines are associated with the development of psoriasis.
  
  
  OBJECTIVE
  The purpose of this study was to determine the changes in adipokine levels, insulin resistance, hypertension, and dyslipidemia over a 12-week period.
  
  
  METHODS
  The study comprised 35 psoriasis patients and 50 controls. Blood samples were obtained twice from the patients, one sample at the start and one at the end of a 12-week follow-up period. The following parameters were assessed in both groups: serum fasting glucose, fasting insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, serum lipids, adiponectin, leptin, resistin, chemerin, omentin, vaspin, visfatin, retinol-binding protein 4, and high-sensitivity C-reactive protein (hs-CRP) levels; blood pressure; body mass index; and the psoriasis area severity index (PASI) scores.
  
  
  RESULTS
  The patients showed an improvement in the PASI score and a significant decrease in serum hs-CRP, omentin, and chemerin values. Moreover, at the start of the follow-up, the psoriasis patients had significantly lower levels of adiponectin and visfatin and significantly higher levels of vaspin and resistin than those of the control group. Visfatin levels correlated negatively with low-density lipoprotein (LDL) and cholesterol, while vaspin and omentin levels correlated positively with diastolic blood pressure. Decreased adiponectin levels correlated negatively with diastolic blood pressure and LDL.
  
  
  CONCLUSIONS
  Plasma levels of adipokines might be useful for evaluating the disease activity of psoriasis and its comorbidities.
authors: Department of Dermatology and Venereology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Melis
authors: M
authors: Coban
authors: Department of Dermatology and Venereology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Levent
authors: L
authors: Tasli
authors: Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Sebahat
authors: S
authors: Turgut
authors: Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Seyma
authors: S
authors: Özkan
authors: Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Melek
authors: M
authors: Tunç Ata
authors: Department of Endocrinology and Metabolism, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Fulya
authors: F
authors: Akın
keywords: Adipokines; C-reactive protein; Psoriasis