title: Ghrelin, GLP-1, and leptin responses during exposure to moderate hypoxia.
abstract: Severe hypoxia has been indicated to cause acute changes in appetite-related hormones, which attenuate perceived appetite. However, the effects of moderate hypoxia on appetite-related hormonal regulation and perceived appetite have not been elucidated. Therefore, we examined the effects of moderate hypoxia on appetite-related hormonal regulation and perceived appetite. Eight healthy males (21.0 ± 0.6 years; 173 ± 2.3 cm; 70.6 ± 5.0 kg; 23.4 ± 1.1 kg/m(2)) completed two experimental trials on separate days: a rest trial in normoxia (FiO2 = 20.9%) and a rest trial in hypoxia (FiO2 = 15.0%). The experimental trials were performed over 7 h in an environmental chamber. Blood samples and scores of subjective appetite were collected over 7 h. Standard meals were provided 1 h (745 kcal) and 4 h (731 kcal) after initiating exposure to hypoxia or normoxia within the chamber. Although each meal significantly reduced plasma active ghrelin concentrations (P < 0.05), the response did not differ significantly between the trials over 7 h. No significant differences in the area under the curves for plasma active ghrelin concentrations over 7 h were observed between the two trials. No significant differences were observed in glucagon-like peptide 1 or leptin concentrations over 7 h between the trials. The subjective feeling of hunger and fullness acutely changed in response to meal ingestions. However, these responses were not affected by exposure to moderate hypoxia. In conclusion, 7 h of exposure to moderate hypoxia did not change appetite-related hormonal responses or perceived appetite in healthy males.
authors: a Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1, Nojihigashi, Kusatsu, Shiga, 525-8577, Japan.|b Research Fellow of the Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan.
authors: Takuma
authors: T
authors: Morishima
authors: a Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1, Nojihigashi, Kusatsu, Shiga, 525-8577, Japan.
authors: Kazushige
authors: K
authors: Goto
mesh_terms: D000328:Adult; D001066:Appetite / Q000502:physiology; D001069:Appetite Regulation / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight; D018592:Cross-Over Studies; D002149:Energy Intake; D054439:Ghrelin / Q000097:blood*; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000175:diagnosis; D020738:Leptin / Q000097:blood*; D008297:Male; D019518:Postprandial Period / Q000502:physiology; D055815:Young Adult
chemical_list: D054439:Ghrelin; D020738:Leptin; D052216:Glucagon-Like Peptide 1
keywords: GLP-1; appetite regulation; ghrelin; ghréline; hypoxie modérée; leptin; leptine; moderate hypoxia; perceived appetite; régulation de l’appétit; sensation de faim