title: [Neonatal cholestasis].
abstract: "Cholestasis" means abnormal synthesis or secretion of bile. The main symptom in a neonate or infant is jaundice. Urine is dark, staining diapers, and stools are variably pale or white. Vitamin K should be injected (to prevent coagulation disorders due to malabsorption). The two diagnoses requiring urgent treatment are urinary tract infection and biliary atresia. If stools are permanently white, biliary atresia is highly probable. A few genetic causes of intrahepatic cholestasis should be screened and corrective surgery organized. The diseases responsible for cholestasis in this age group are described as well as the investigations and treatments, including the management of non-specific complications of cholestasis. A delay in the diagnosis of biliary atresia can have such severe consequences that consultation with a hepatology unit or transfer should be easy and rapid.
authors: Service de gastroentérologie-hépatologie-nutrition pédiatrique, hôpital universitaire Necker-Enfants-Malades, 149, rue de Sèvres, 75015 Paris, France. Electronic address: florence.lacaille@aphp.fr.
authors: F
authors: F
authors: Lacaille
mesh_terms: D002779:Cholestasis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn