title: Hyperhomocysteinaemia is an independent risk factor of abdominal aortic aneurysm in a Chinese Han population.
abstract: The associations between hyperhomocysteinaemia (HHcy), methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, and abdominal aortic aneurysm (AAA) remain controversial, with only few studies focused on these associations within the Chinese population. We performed subgroup and interaction analyses in a Chinese Han population to investigate these associations. In all, 155 AAA patients and 310 control subjects were evaluated for serum total homocysteine levels and MTHFR C677T polymorphisms. Multiple logistic regression models were used to evaluate the aforementioned associations. Interaction and stratified analyses were conducted according to age, sex, smoking status, drinking status, and chronic disease histories. The multiple logistic analyses showed a significant association between HHcy and AAA but no significant association between MTHFR C677T polymorphism and AAA. The interaction analysis showed that age and peripheral arterial disease played an interactive role in the association between HHcy and AAA, while drinking status played an interactive role in the association between MTHFR C677T polymorphism and AAA. In conclusion, HHcy is an independent risk factor of AAA in a Chinese Han population, especially in the elderly and peripheral arterial disease subgroups. Longitudinal studies and clinical trials aimed to reduce homocysteine levels are warranted to assess the causal nature of these relationships.
authors: Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors: Jie
authors: J
authors: Liu
authors: Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors: Shang Wei
authors: SW
authors: Zuo
authors: Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors: Yue
authors: Y
authors: Li
authors: Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors: Xin
authors: X
authors: Jia
authors: Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors: Sen Hao
authors: SH
authors: Jia
authors: Department of Vascular Surgery, Peking University People's Hospital. Beijing 100044, China.
authors: Tao
authors: T
authors: Zhang
authors: Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors: Yu Xiang
authors: YX
authors: Song
authors: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
authors: Ying Qi
authors: YQ
authors: Wei
authors: Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors: Jiang
authors: J
authors: Xiong
authors: Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
authors: Yong Hua
authors: YH
authors: Hu
authors: Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors: Wei
authors: W
authors: Guo
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000208:ethnology / Q000235:genetics; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D006710:Homocysteine / Q000097:blood / Q000235:genetics; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000208:ethnology / Q000235:genetics; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D006710:Homocysteine; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)