title: Mediator Architecture and RNA Polymerase II Interaction.
abstract: Integrated structural biology recently elucidated the architecture of Mediator and its position on RNA polymerase II. Here we summarize these achievements and list open questions on Mediator structure and mechanism.
authors: Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077, Göttingen, Germany.
authors: Clemens
authors: C
authors: Plaschka
authors: Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077, Göttingen, Germany.
authors: Kayo
authors: K
authors: Nozawa
authors: Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077, Göttingen, Germany. Electronic address: patrick.cramer@mpibpc.mpg.de.
authors: Patrick
authors: P
authors: Cramer
mesh_terms: D006801:Humans; D056892:Mediator Complex / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology; D015533:Transcriptional Activation / Q000502:physiology
chemical_list: D056892:Mediator Complex; D012319:RNA Polymerase II
keywords: RNA polymerase II; coactivator; gene transcription; multiprotein complex