title: Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment.
abstract: Keloids, fibroproliferative dermal tumors with effusive accumulation of extracellular matrix (ECM) components, particularly collagen, result from excessive expression of growth factors and cytokines. The etiology of keloids is unknown but they occur after dermal injury in genetically susceptible individuals, and they cause both physical and psychological distress for the affected individuals. Several treatment methods for keloids exist, including the combination therapy of surgical excision followed by intralesional steroid therapy, however, they have high recurrence rate regardless of the current treatment method. Improved understanding of the pathomechanisms leading to keloid formation will hopefully identify pathways that serve as specific targets to improve therapy for this devastating, currently intractable, disorder.
authors: Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
authors: Jonathan P
authors: JP
authors: Andrews
authors: Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
authors: Jaana
authors: J
authors: Marttala
authors: Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA; The Joan and Joel Rosenbloom Research Center for Fibrotic Diseases, Thomas Jefferson University, Philadelphia, PA, USA.
authors: Edward
authors: E
authors: Macarak
authors: Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA; The Joan and Joel Rosenbloom Research Center for Fibrotic Diseases, Thomas Jefferson University, Philadelphia, PA, USA.
authors: Joel
authors: J
authors: Rosenbloom
authors: Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA; Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: jouni.uitto@jefferson.edu.
authors: Jouni
authors: J
authors: Uitto
mesh_terms: D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D005347:Fibroblasts / Q000473:pathology; D005355:Fibrosis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007627:Keloid / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012867:Skin / Q000293:injuries / Q000473:pathology*; D013256:Steroids / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D013256:Steroids; D003094:Collagen
keywords: Collagen; Fibrotic disease; Inflammation; Keloid; TGF-β; Wound healing