title: Bioanalytical techniques in nontargeted clinical lipidomics.
abstract: Lipidomic analysis aims at comprehensive characterization of molecular lipids in biological systems. Due to the central role of lipid metabolism in many devastating diseases, lipidomics is being increasingly applied in biomedical research. Over the past years, advances in analytical techniques and bioinformatics enabled increasingly comprehensive and accurate coverage of lipids both in tissues and biofluids, yet many challenges remain. This review highlights recent progress in the domain of analytical lipidomics, with main emphasis on non-targeted methodologies for large scale clinical applications, as well as discusses some of the key challenges and opportunities in this field.
authors: Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark.|Turku Centre for Biotechnology, University of Turku & Åbo Akademi University, Turku, Finland.
authors: Tuulia
authors: T
authors: Hyötyläinen
authors: Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark.|Turku Centre for Biotechnology, University of Turku & Åbo Akademi University, Turku, Finland.
authors: Matej
authors: M
authors: Orešič
mesh_terms: D000375:Aging / Q000378:metabolism; D004032:Diet; D006801:Humans; D050356:Lipid Metabolism; D055432:Metabolomics / Q000379:methods*; D019518:Postprandial Period; D012727:Sex Characteristics
keywords: MS; clinical analysis; lipidomics; non-targeted analysis; preanalytical factors