title: [Effect of Hepatic P450 2e1 Activity Modulation on the Toxicity and Carcinogenicity of Diethylnitrosamine in Mice].
abstract: In this paper, the biological effects of diethylnitrosamine have been studied under controlled conditions of its metabolism in mice of different ages. The data presented indicate that diethylnitrosamine in a non-metabolized form exerts general toxic and hepatocarcinogenic effects while alkylating agents of this compound produce toxic liver injury. To our knowledge, the data presented impel to revise the general notion of an exceptional role of mutagenic activation in the carcinogenic effect of chemicals.
authors: V I
authors: VI
authors: Kaledin
authors: S I
authors: SI
authors: Ilnitskaya
authors: E A
authors: EA
authors: Vasyunina
authors: N A
authors: NA
authors: Popova
authors: L A
authors: LA
authors: Bogdanova
authors: M L
authors: ML
authors: Perepechaeva
authors: A Y
authors: AY
authors: Grishanova
mesh_terms: D000477:Alkylating Agents / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D063646:Carcinogenesis / Q000187:drug effects*; D019392:Cytochrome P-450 CYP2E1 / Q000187:drug effects / Q000378:metabolism; D004052:Diethylnitrosamine / Q000008:administration & dosage / Q000633:toxicity*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000293:injuries / Q000473:pathology; D051379:Mice; D009153:Mutagens / Q000008:administration & dosage
chemical_list: D000477:Alkylating Agents; D009153:Mutagens; D004052:Diethylnitrosamine; D019392:Cytochrome P-450 CYP2E1