title: Birth outcome measures and prenatal exposure to 4-tert-octylphenol.
abstract: Exposure to 4-tert-octylphenol (tOP) has been linked with adverse health outcomes in animals and humans, while epidemiological studies about associations between prenatal exposure to tOP and fetal growth are extremely limited. We measured urinary tOP concentrations in 1100 pregnant women before their delivery, and examined whether tOP levels were associated with birth outcomes, including weight, length, head circumference and ponderal index at birth. tOP could be detected in all samples, and the median uncorrected and creatinine-corrected tOP concentrations were 0.90 μg/L (range from 0.25 to 20.05 μg/L) and 1.33 μg/g creatinine (range from 0.15 to 42.49 μg/g creatinine), respectively. Maternal urinary log-transformed tOP concentrations were significantly negatively associated with adjusted birth weight [β (g) = -126; 95% confidence interval (CI): -197, -55], birth length [β (cm) = -0.53; 95% CI:-0.93, -0.14], and head circumference [β (cm) = -0.30; 95% CI: -0.54, -0.07], respectively. Additionally, considering sex difference, these significant negative associations were also found among male neonates, while only higher maternal tOP concentrations were associated with a significant decrease in birth weight among female neonates. This study suggested significant negative associations between maternal urinary tOP concentrations and neonatal sizes at birth, and they differed by neonatal sex. Further epidemiological studies are required to more fully elaborate the associations between prenatal tOP exposure and birth outcomes.
authors: School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No. 130, Dong' an Road, Shanghai, 200032, China. Electronic address: 12211020014@fudan.edu.cn.
authors: Shenliang
authors: S
authors: Lv
authors: School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No. 130, Dong' an Road, Shanghai, 200032, China. Electronic address: chwu@shmu.edu.cn.
authors: Chunhua
authors: C
authors: Wu
authors: Shanghai Municipal Center for Disease Control and Prevention, No. 1380, Zhongshan West Road, Shanghai, 200336, China. Electronic address: ludasheng@scdc.sh.cn.
authors: Dasheng
authors: D
authors: Lu
authors: School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No. 130, Dong' an Road, Shanghai, 200032, China; Zhejiang Provincial Center for Disease Control and Prevention, No. 3399, Binsheng Road, Hangzhou, 310051, China. Electronic address: xjqi@cdc.zj.cn.
authors: Xiaojuan
authors: X
authors: Qi
authors: Changning District, Shanghai Center for Disease Control and Prevention, Shanghai, 200051, China. Electronic address: cnwj6274@163.com.
authors: Hao
authors: H
authors: Xu
authors: School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No. 130, Dong' an Road, Shanghai, 200032, China. Electronic address: 14211020052@fudan.edu.cn.
authors: Jianqiu
authors: J
authors: Guo
authors: Changning District, Shanghai Center for Disease Control and Prevention, Shanghai, 200051, China. Electronic address: wj8501@aliyun.com.
authors: Weijiu
authors: W
authors: Liang
authors: School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No. 130, Dong' an Road, Shanghai, 200032, China. Electronic address: xlchang@shmu.edu.cn.
authors: XiuLi
authors: X
authors: Chang
authors: Shanghai Municipal Center for Disease Control and Prevention, No. 1380, Zhongshan West Road, Shanghai, 200336, China. Electronic address: gqwang@scdc.sh.cn.
authors: Guoquan
authors: G
authors: Wang
authors: School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, No. 130, Dong' an Road, Shanghai, 200032, China. Electronic address: zjzhou@fudan.edu.cn.
authors: Zhijun
authors: Z
authors: Zhou
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000187:drug effects*; D004785:Environmental Pollutants / Q000633:toxicity* / Q000652:urine; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D010636:Phenols / Q000633:toxicity* / Q000652:urine; D011247:Pregnancy; D011256:Pregnancy Outcome; D012737:Sex Factors; D013501:Surface-Active Agents / Q000633:toxicity*; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D010636:Phenols; D013501:Surface-Active Agents; C105260:4-tert-octylphenol
keywords: 4-tert-octylphenol; Birth outcomes; Prenatal exposure; Urinary biomarker