title: Rhodium-Catalyzed Cyclization of 2-Ethynylanilines in the Presence of Isocyanates: Approach toward Indole-3-carboxamides.
abstract: Catalytic synthesis of indole-3-carboxamides from 2-ethynylanilines and isocyanates was achieved in the presence of a rhodium catalyst through a tandem-type, cyclization-addition sequence. This tandem-type process can be performed under mild reaction conditions, affording 2,3-disubstituted indoles in a one-pot manner generally in good to excellent yields. The broad substrate scope and good functional group compatibility make the method highly efficient and widely applicable, providing a facile and entirely novel route toward variously substituted indole-3-carboxamides.
authors: School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University , 11-68, 9-Bancho, Koshien, Nishinomiya, Hyogo 663-8179, Japan.
authors: Akiho
authors: A
authors: Mizukami
authors: School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University , 11-68, 9-Bancho, Koshien, Nishinomiya, Hyogo 663-8179, Japan.
authors: Yumi
authors: Y
authors: Ise
authors: School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University , 11-68, 9-Bancho, Koshien, Nishinomiya, Hyogo 663-8179, Japan.
authors: Tetsutaro
authors: T
authors: Kimachi
authors: School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University , 11-68, 9-Bancho, Koshien, Nishinomiya, Hyogo 663-8179, Japan.
authors: Kiyofumi
authors: K
authors: Inamoto
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D017953:Isocyanates / Q000737:chemistry*; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*
chemical_list: C483919:2-ethynylaniline; D000814:Aniline Compounds; D007211:Indoles; D017953:Isocyanates; D012238:Rhodium; D000114:Acetylene