title: Comparison of Paclitaxel-Coated Balloon Treatment and Plain Old Balloon Angioplasty for De Novo Coronary Lesions.
abstract: OBJECTIVE
  This study compared the angiographic outcomes of paclitaxel-coated balloon (PCB) versus plain old balloon angioplasty (POBA) treatment for de novo coronary artery lesions. At present, there is no available data comparing the efficacy of PCB versus POBA for the treatment of de novo coronary lesions.
  
  
  METHODS
  This multicenter retrospective observational study enrolled patients with de novo coronary lesions with a reference vessel diameter between 2.5 mm and 3.0 mm and lesion length ≤ 24 mm who were successfully treated with PCB or POBA. Angiographic measurements and quantitative coronary analysis were performed before and after the procedure, and at 9 months follow-up.
  
  
  RESULTS
  A total of 72 patients (49 receiving PCB and 23 receiving POBA) were enrolled in this study. Late luminal loss was -0.12 ± 0.30 mm in the PCB group and 0.25 ± 0.50 mm in the POBA group (p<0.001). There was a higher percentage of binary restenosis (diameter stenosis ≥ 50%) in POBA, compared to PCB (30.4%, n=7 vs. 4.1%, n=2, p<0.001). Target vessel revascularization was higher in the POBA group (13.0%, n=3 vs. 0%, p=0.033).
  
  
  CONCLUSIONS
  PCB treatment of de novo coronary lesions showed better 9-month angiographic outcomes than POBA treatment alone.
authors: Division of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
authors: Ae Young
authors: AY
authors: Her
authors: Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
authors: Soe Hee
authors: SH
authors: Ann
authors: Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
authors: Gillian Balbir
authors: GB
authors: Singh
authors: Division of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
authors: Yong Hoon
authors: YH
authors: Kim
authors: Division of Cardiology, Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea.
authors: Sang Yong
authors: SY
authors: Yoo
authors: East Lancashire Hospitals NHS Trust, Blackburn, Lancashire, UK.
authors: Scot
authors: S
authors: Garg
authors: Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea.
authors: Bon Kwon
authors: BK
authors: Koo
authors: Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. sesim1989@gmail.com.
authors: Eun Seok
authors: ES
authors: Shin
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation* / Q000379:methods; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000628:therapy; D023921:Coronary Stenosis / Q000628:therapy*; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage* / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D017239:Paclitaxel
keywords: Paclitaxel-coated balloon; de novo coronary lesion; plain old balloon angioplasty; restenosis; revascularization