title: The non-power model of the genetic code: a paradigm for interpreting genomic information.
abstract: In this article, we present a mathematical framework based on redundant (non-power) representations of integer numbers as a paradigm for the interpretation of genomic information. The core of the approach relies on modelling the degeneracy of the genetic code. The model allows one to explain many features and symmetries of the genetic code and to uncover hidden symmetries. Also, it provides us with new tools for the analysis of genomic sequences. We review briefly three main areas: (i) the Euplotid nuclear code, (ii) the vertebrate mitochondrial code, and (iii) the main coding/decoding strategies used in the three domains of life. In every case, we show how the non-power model is a natural unified framework for describing degeneracy and deriving sound biological hypotheses on protein coding. The approach is rooted on number theory and group theory; nevertheless, we have kept the technical level to a minimum by focusing on key concepts and on the biological implications.
authors: Dipartimento di Scienze Statistiche, Università di Bologna, Via delle Belle Arti 41, 40126 Bologna, Italy CNR-IMM, Sezione di Bologna, Via Gobetti 101, 40129 Bologna, Italy.
authors: Diego Luis
authors: 0000-0001-9646-9900
authors: DL
authors: Gonzalez
authors: Dipartimento di Scienze Statistiche, Università di Bologna, Via delle Belle Arti 41, 40126 Bologna, Italy simone.giannerini@unibo.it.
authors: Simone
authors: 0000-0002-0710-668X
authors: S
authors: Giannerini
authors: CNR-IMM, Sezione di Bologna, Via Gobetti 101, 40129 Bologna, Italy.
authors: Rodolfo
authors: R
authors: Rosa
mesh_terms: D001483:Base Sequence; D005815:Genetic Code / Q000235:genetics*; D023281:Genomics; D008928:Mitochondria / Q000235:genetics; D008957:Models, Genetic
keywords: degeneracy; genetic code; numeration systems; symmetry