title: [Assessment of Antitumor Effect of Submerged Culture of Ophiocordyceps sinensis and Cordyceps militaris].
abstract: Ophiocordyceps sinensis and Cordyceps militaris metabolites showed a high potential in the treatment of tumors as well as some other diseases. Antitumor properties of O. sinensis and C. militaris submerged mycelium were investigated. It was found that the O. sinensis dry biomass in a dose of 50 mg/kg administered once a day to the mice with subcutaneously inoculated P388 lympholeucosis lowered the tumor growth by 65% vs. 54% for the C. militaris dry biomass. The water extract of O. sinensis submerged culture however accelerated the growth of the P388 lympholeucosis tumor node in the mice almost two times, compared to the control. A greater caution in using this fungus as a source of biologically active substances is required since unwanted tumor-stimulating effects can arise.
authors: A V
authors: AV
authors: Avtonomova
authors: L M
authors: LM
authors: Krasnopolskaya
authors: M I
authors: MI
authors: Shuktueva
authors: E B
authors: EB
authors: Isakova
authors: V M
authors: VM
authors: Bukhman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002678:Chimera; D032661:Cordyceps / Q000737:chemistry*; D003890:Desiccation; D004334:Drug Administration Schedule; D007941:Leukemia P388 / Q000473:pathology / Q000628:therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D025282:Mycelium / Q000737:chemistry*; D011208:Powders; D004718:Saccharomycetales / Q000737:chemistry*; D013535:Suspensions
chemical_list: D000970:Antineoplastic Agents; D011208:Powders; D013535:Suspensions