title: Primary Intracranial Alveolar Soft-Part Sarcoma: Report of Two Cases and a Review of the Literature.
abstract: BACKGROUND
  Alveolar soft part sarcoma (ASPS), a rare malignant soft-tissue sarcoma affecting mainly adolescents and young children, frequently metastasizes to the brain. Primary intracranial ASPS, however, is extremely rare. We present 2 cases of primary intracranial ASPS without demonstrable systemic lesions.
  
  
  METHODS
  We report 2 cases of primary intracranial lesions that were surgically treated, and a postoperative diagnosis of ASPS was determined in both of the cases. The tumor in the 28-year-old female patient completely resolved after a treatment course consisting of surgical intervention and radiotherapy. After a follow-up period of 27 months, the patient was tumor-free. The other patient was a 13-year-old boy with a right middle cranial fossa tumor who experienced subtotal surgery, experienced a tumor relapse, and died 2 years after surgery.
  
  
  CONCLUSIONS
  This is the fifth report about primary intracranial ASPS. We herein present the clinical pathologic characteristics, imaging features, and differential diagnosis of primary ASPS of the brain. Gross total resection is the most effective therapeutic option for primary intracranial ASPS.
authors: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
authors: Xiaogang
authors: X
authors: Tao
authors: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
authors: Runfa
authors: R
authors: Tian
authors: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
authors: Shuyu
authors: S
authors: Hao
authors: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
authors: Huan
authors: H
authors: Li
authors: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
authors: Zhixian
authors: Z
authors: Gao
authors: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China; Department of Neurotrauma, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Nerve Injury and Repair Center of Beijing Institute for Brain Disorders, Beijing, China; Department of Neurotrauma, General Hospital of the Armed Police Force, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Beijing Key Laboratory of Central Nervous System Injury, Beijing, China. Electronic address: liubaiyun1963@163.com.
authors: Baiyun
authors: B
authors: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control*; D019635:Neurosurgical Procedures / Q000379:methods*; D018714:Radiotherapy, Adjuvant / Q000379:methods; D018234:Sarcoma, Alveolar Soft Part / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome
keywords: Alveolar soft part sarcoma; Gross total resection; Intracranial; Primary; Transcription factor E3