title: Differential Neural Correlates of Set-Shifting in the Bingeing-Purging and Restrictive Subtypes of Anorexia Nervosa: An fMRI Study.
abstract: In this study, possible differences in the neural correlates of set-shifting abilities between the restrictive (AN-R) and bingeing/purging (AN-BP) subtypes of anorexia nervosa have been explored. Three groups of participants performed a set-shifting task during functional magnetic resonance imaging: patients with AN-R (N = 16), AN-BP (N = 13) and healthy control participants (N = 15). As in a typical set-shifting experiment, participants had to switch between two easy tasks (i.e. 'Is the presented number odd/even' or 'Is the presented number smaller/larger than 5'). The trials in which the task was repeated (repeat trials) were compared with trials in which the task was switched (switch trials). With regards to the level of task performance, no significant group differences could be established. However, when comparing switch specific brain activity across study groups, a stronger activation was found in the insula and the precuneus in AN-R when compared to AN-BP and HC. These results suggest that the both subtypes of AN might have different neurobiological correlates, and thus, might benefit from different treatment approaches. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
authors: Department of Psychiatry and Medical Psychology, Faculty of Medicine and Health Sciences, Ghent University, Belgium.
authors: Sara
authors: S
authors: Van Autreve
authors: Department of Experimental Psychology, Faculty of Psychology and Educational Sciences, Ghent University, Belgium.|Department of Cognitive Neuropsychology, Tilburg University, The Netherlands.
authors: Wouter
authors: W
authors: De Baene
authors: Department of Psychiatry and Medical Psychology, Faculty of Medicine and Health Sciences, Ghent University, Belgium.
authors: Chris
authors: C
authors: Baeken
authors: Department of Psychiatry and Medical Psychology, Faculty of Medicine and Health Sciences, Ghent University, Belgium.
authors: Kees
authors: K
authors: van Heeringen
authors: Department of Psychiatry and Medical Psychology, Faculty of Medicine and Health Sciences, Ghent University, Belgium.
authors: Nikita
authors: N
authors: Vancayseele
authors: Department of Psychiatry and Medical Psychology, Faculty of Medicine and Health Sciences, Ghent University, Belgium.
authors: Myriam
authors: M
authors: Vervaet
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000145:classification / Q000000981:diagnostic imaging*; D056912:Binge-Eating Disorder / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D003071:Cognition; D056344:Executive Function; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011569:Psychiatric Status Rating Scales; D012718:Set, Psychology
keywords: anorexia nervosa; insula; mental flexibility; precuneus