title: Dendritic Cells in Colorectal Cancer and a Potential for their Use in Therapeutic Approaches.
abstract: Multiple pathogenic mechanisms contribute to the development of colorectal cancer. This tumor is characterized by high chemoresistance and low immunogenicity due to the effective mechanisms of immunosuppression. Dendritic cells (DCs) play a key role in recognition of tumor antigens and induction of T-cell-primed anticancer response. However, in cancer microenvironment, the function of tumor-infiltrating DCs becomes impaired and switched from the immunostimulation to the immunosuppression. Colorectal cancer cells express anti-inflammatory cytokines such as IL-10 and TGF-β that could affect DC phenotype and support tumor escape from the immune surveillance. As a result, tumor-associated DCs display numerous defects in antigen-presenting capacity and have an altered pattern of expression of immune costimulatory molecules towards the immunoregulatory phenotype. Indeed, understanding of mechanisms, such as how tumor could impair activity of DCs, would help in the development of new DC-based vaccines against colorectal cancer.
authors: Dimitry A
authors: DA
authors: Chistiakov
authors: Alexander N
authors: AN
authors: Orekhov
authors: Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. y.bobryshev@unsw.edu.au.
authors: Yuri V
authors: YV
authors: Bobryshev
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000276:immunology / Q000628:therapy*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans
chemical_list: D019496:Cancer Vaccines