title: Brain stimulation: Neuromodulation as a potential treatment for motor recovery following traumatic brain injury.
abstract: There is growing evidence that electrical and magnetic brain stimulation can improve motor function and motor learning following brain damage. Rodent and primate studies have strongly demonstrated that combining cortical stimulation (CS) with skilled motor rehabilitative training enhances functional motor recovery following stroke. Brain stimulation following traumatic brain injury (TBI) is less well studied, but early pre-clinical and human pilot studies suggest that it is a promising treatment for TBI-induced motor impairments as well. This review will first discuss the evidence supporting brain stimulation efficacy derived from the stroke research field as proof of principle and then will review the few studies exploring neuromodulation in experimental TBI studies. This article is part of a Special Issue entitled SI:Brain injury and recovery.
authors: Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States.
authors: E
authors: E
authors: Clayton
authors: Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States.
authors: S K
authors: SK
authors: Kinley-Cooper
authors: Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States.
authors: R A
authors: RA
authors: Weber
authors: Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States; Department of Health Sciences and Research, Medical University of South Carolina, Charleston, SC 29425, United States; Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC 29425, United States. Electronic address: adkinsdl@musc.edu.
authors: D L
authors: DL
authors: Adkins
mesh_terms: D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000503:physiopathology / Q000628:therapy*; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D009043:Motor Activity / Q000502:physiology; D000066530:Neurological Rehabilitation / Q000379:methods; D020127:Recovery of Function / Q000502:physiology; D065908:Transcranial Direct Current Stimulation / Q000379:methods*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
keywords: Epidural stimulation; Motor cortex; Rehabilitative training; Transcranial direct stimulation (tDCS); Transcranial stimulation (TMS)