title: Photocontrolled Cargo Release from Dual Cross-Linked Polymer Particles.
abstract: Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. This was achieved via a dual cross-linking concept whereby noncovalent cross-linking was provided by cyclodextrin host-guest interactions, and irreversible covalent cross-linking was mediated by continuous assembly of polymers (CAP). The dual cross-linked particles (DCPs) were efficiently infiltrated (∼80-93%) by the biomacromolecule dextran (molecular weight up to 500 kDa) to provide high loadings (70-75%). Upon short exposure (5 s) to UV light, the noncovalent cross-links were disrupted resulting in increased permeability and burst release of the cargo (50 mol % within 1 s) as visualized by time-lapse fluorescence microscopy. As sunlight contains UV light at low intensities, the particles can potentially be incorporated into systems used in agriculture, environmental control, and food packaging, whereby sunlight could control the release of nutrients and antimicrobial agents.
authors: Polymer Science Group, Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors: Shereen
authors: S
authors: Tan
authors: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors: Jiwei
authors: J
authors: Cui
authors: Polymer Science Group, Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors: Qiang
authors: Q
authors: Fu
authors: Polymer Science Group, Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors: Eunhyung
authors: E
authors: Nam
authors: Polymer Science Group, Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors: Katharina
authors: K
authors: Ladewig
authors: Polymer Science Group, Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors: Jing M
authors: JM
authors: Ren
authors: Polymer Science Group, Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors: Edgar H H
authors: EH
authors: Wong
authors: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors: Frank
authors: F
authors: Caruso
authors: School of Pharmacy and Medical Sciences, Division of Health Sciences, The University of South Australia , Adelaide, South Australia 5001, Australia.
authors: Anton
authors: A
authors: Blencowe
authors: Polymer Science Group, Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors: Greg G
authors: GG
authors: Qiao
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D003505:Cyclodextrins / Q000737:chemistry*; D000067493:Dynamic Light Scattering; D018857:Food Packaging; D006367:HeLa Cells; D006801:Humans; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D011108:Polymers / Q000737:chemistry*; D059008:Time-Lapse Imaging; D014466:Ultraviolet Rays
chemical_list: D001672:Biocompatible Materials; D003505:Cyclodextrins; D011108:Polymers
keywords: cyclodextrin; delivery; entrapment; particle; polymerization; supramolecular chemistry