title: Nocturnal oxygen therapy in patients with chronic heart failure and sleep apnea: a systematic review.
abstract: Chronic heart failure (CHF) is a public health problem which affects >2% of the adult population, with high morbidity, mortality, and financial cost. Sleep apnea, prevalent in >50% of patients with CHF, can aggravate vital prognosis due to worsening of heart failure. It is considered that a decrease in the apnea-hypopnea load may improve outcomes for those patients. Nocturnal non invasive ventilation can be proposed to treat sleep apnea in this situation, there being few alternatives. The present review concerns the use of nocturnal oxygen therapy (NOT) in patients suffering from both CHF and sleep apnea. The interest of NOT in this situation lies in its ability to reduce the central apnea-hypopnea index and to improve nocturnal oximetry disorders related to sleep apnea. Impact on cardiac contractility, patient tolerance, side effects, and costs of NOT are also approached as well as the underlying mechanisms of NOT. In addition, the results of the SERVE-HF trial have shown an increased death rate in patients with CHF and central sleep apnea and who were treated with adaptive servo-ventilation versus control patients. This may lead to renewed interest in NOT in those patients.
authors: Haut-Leveque Cardiovascular Hospital, Pessac, France. Electronic address: phibordier@aol.com.
authors: Philippe
authors: P
authors: Bordier
authors: Haut-Leveque Cardiovascular Hospital, Pessac, France.
authors: Aurelia
authors: A
authors: Lataste
authors: Haut-Leveque Cardiovascular Hospital, Pessac, France.
authors: Pauline
authors: P
authors: Hofmann
authors: Haut-Leveque Cardiovascular Hospital, Pessac, France.
authors: Frederic
authors: F
authors: Robert
authors: Haut-Leveque Cardiovascular Hospital, Pessac, France.
authors: Ghalia
authors: G
authors: Bourenane
mesh_terms: D002908:Chronic Disease; D006333:Heart Failure / Q000150:complications / Q000628:therapy*; D006801:Humans; D010092:Oximetry; D010102:Oxygen Inhalation Therapy; D011175:Positive-Pressure Respiration / Q000379:methods; D020182:Sleep Apnea, Central / Q000150:complications / Q000628:therapy*
keywords: Cheyne–Stokes respiration; Heart failure; Oxygen therapy; Sleep apnea