title: Thyroid nodule: not as clear-cut as it seems.
abstract: Benign etiologies and primary thyroid cancers are the most common causes of incidental thyroid nodules. Clinically evident metastases to the thyroid gland are not common and account for 2%-3% of thyroid cancers, though the incidence of thyroid metastases reaches 24% in autopsy studies.1 The most common clinically detected thyroid metastases originate from renal cell carcinoma (RCC; 48.1%).2 We report here a rare case of a man with clear-cell RCC with late recurrence in the thyroid gland as a solitary metastasis, 13 years after the primary diagnosis. The patient received neo-adjuvant targeted therapy with sunitinib, then underwent thyroidectomy. The surgical margins were positive, and the patient had adjuvant radiation therapy. He is currently on long-term surveillance.
authors: East Tennessee State University, Quillen College of Medicine, Medical Oncology and Hematology, Johnson City, Tennessee, USA.
authors: Gilbert
authors: G
authors: Bader
authors: Vanderbilt University Medical Center, Division of Hematology-Oncology, Nashville, Tennessee, USA.
authors: Igor
authors: I
authors: Puzanov
authors: East Tennessee State University, Quillen College of Medicine, Medical Oncology and Hematology, Johnson City, Tennessee, USA. chakrabk@mail.etsu.edu.
authors: Kanishka
authors: K
authors: Chakraborty
keywords: renal cell cancer; sunitinib; surgical resection; thyroid metastases