title: Upregulated CCL28 expression in the nasal mucosa in experimental allergic rhinitis: Implication for CD4(+) memory T cell recruitment.
abstract: During nasal immune responses, lymphocytes activated in the nasopharynx-associated lymphoid tissue (NALT) are thought to traffic to the nasal mucosa. Here we found a prominent infiltration of CD4(+) memory T cells into the nasal mucosa in a mouse model of allergic rhinitis. CCR3 and CCR10 mRNA was increased in the NALT, and CCR3- or CCR10-expressing CD4(+) T cells were present in the nasal mucosa. CCL28, a chemokine ligand for CCR3 and CCR10, was upregulated in nasal epithelial cells. Our results suggest that memory CD4(+) T cells traffic to the nasal mucosa in a process that may involve CCL28 and its receptors CCR3 and CCR10.
authors: Department of Fundamental Biosciences, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
authors: Daisuke
authors: D
authors: Nagakubo
authors: Department of Microbiology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.
authors: Osamu
authors: O
authors: Yoshie
authors: Department of Fundamental Biosciences, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan. Electronic address: tahirata@belle.shiga-med.ac.jp.
authors: Takako
authors: T
authors: Hirata
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D019742:Chemokines, CC / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D007156:Immunologic Memory; D051379:Mice; D009297:Nasal Mucosa / Q000276:immunology*; D019707:Receptors, Chemokine / Q000235:genetics / Q000378:metabolism; D065631:Rhinitis, Allergic / Q000503:physiopathology*; D015854:Up-Regulation
chemical_list: C414047:CCL28 protein, human; D019742:Chemokines, CC; D019707:Receptors, Chemokine
keywords: Allergic rhinitis; Chemokine receptors; Chemokines; Lymphocyte trafficking; NALT; T cells