title: Dynamic contrast-enhanced MR in the diagnosis of lympho-associated benign and malignant lesions in the parotid gland.
abstract: OBJECTIVE
  The aim of this study was to determine if dynamic contrast-enhanced (DCE)-MRI can differentiate mucosa-associated lymphoid tissue (MALT) lymphoma from benign lymphoepithelial lesion (BLEL) in the parotid gland.
  
  
  METHODS
  25 patients with tumour-like BLEL and 20 patients with MALT lymphoma in the parotid gland confirmed by pathology were examined pre-operatively using routine MR series and DCE-MRI with a 1.5-T MR unit. The time to peak (TTP), time to start (TTS), SIstart, SImax and SIending were measured and the initial slope of increase (ISI) and relative washout ratio (RWO) were calculated separately from the time-intensity curve (TIC), and the types of TIC were analysed.
  
  
  RESULTS
  There were significant differences in the TTP and ISI between the two lesions (p < 0.001). The sensitivity, specificity and accuracy of TTP were all more than 90%. TICs were divided into three types according to the threshold of TTP and ISI: tumour-like BLEL: gradual type (Type II) and late increase type (Type III); MALT lymphoma: rapid increase and gradual type (Type I).
  
  
  CONCLUSIONS
  DCE-MRI contributed greatly to the differential diagnosis between tumour-like BLEL and MALT lymphoma in the parotid gland.
authors: 1 Department of Radiology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Ling
authors: L
authors: Zhu
authors: 2 Department of Oral pathology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Chunye
authors: C
authors: Zhang
authors: 3 Department of prevention and health care, Preventive and health care center of Wuzhong economic developing-area, Suzhou, China.
authors: Yi
authors: Y
authors: Hua
authors: 4 Division of Oral & Maxillofacial Radiology, Temple University School of Dentistry, and Department of Diagnostic Imaging, Temple University School of Medicine, PA, USA.
authors: Jie
authors: J
authors: Yang
authors: 1 Department of Radiology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Qiang
authors: Q
authors: Yu
authors: 1 Department of Radiology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Xiaofeng
authors: X
authors: Tao
authors: 5 Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Jiawei
authors: J
authors: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D003287:Contrast Media; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010305:Parotid Diseases / Q000175:diagnosis*; D010307:Parotid Neoplasms / Q000175:diagnosis*; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012859:Sjogren's Syndrome / Q000175:diagnosis; D013997:Time Factors; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA
keywords: BLEL; DCE-MRI; MALT lymphoma; parotid gland