title: A tale of two inositol trisphosphates.
abstract: Between spring 1982 and autumn 1984 the physiological role of Ins(1,4,5)P3 as a calcium-mobilizing second messenger was first suggested and then experimentally established. At the same time the unexpected complexity of inositide metabolism began to be exposed by the discovery of Ins(1,3,4)P3. This article recalls my entanglement with these two inositol phosphates.
authors: Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K. rfi20@cam.ac.uk.
authors: Robin
authors: R
authors: Irvine
mesh_terms: D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D007295:Inositol Phosphates / Q000378:metabolism*
chemical_list: D007295:Inositol Phosphates; D015544:Inositol 1,4,5-Trisphosphate; C058097:inositol 1,3,4-trisphosphate
keywords: calcium; inositol; inositol phosphates; inositol trisphosphate