title: Influence of single nucleotide polymorphisms of vitamin D receptor-gene on the level of osteoassociated hormones linkage with postmenopausal osteoporosis.
abstract: The levels of osteoassociated hormones, macroelements, interleukines, cyclic nucleotides and activity of alkaline phosphatase were being detected in the blood plasma of 74 postmenopausal women with and without osteoporosis (OP). Bone mineral density (BMD) and the metacarpal index were being assessed according to the results of densitometry. The allele polymorphisms vitamin D receptor gene (VDR) Cdx2 (rs11568820) and TaqI (rs731236) were being identified with the help of the polymerase chain reaction. The major genotype CC TaqI was found in the group without OP 3.4 times more often than with OP, while the minor genotype TT was found 3.4 times more often with the presence of OP. The presence of the genotype CC TaqI decreased the risk of OP progress by 5.5 times, and the genotype TT TaqI increased by 5.4 times. The presence of the minor allele T was associated with the higher levels of interleukin 1β, BMD and lower testosterone blood level. The major homozygote AA Cdx2 was found in women without OP 2.9 times more often, while the minor genotype GG - 5.4 times more often with the presence of OP. The presence of the major homozygote decreased the risk of OP progress by more than 5.3 times, while the minor homozygote increased the risk by 8 times. The presence of the minor allele G in the genotype was associated with the increase of parathyroid hormone, phosphorus, magnesium, alkaline phosphatase activity in blood, BMD and with the decrease of testosterone, progesterone and calcium blood levels.
authors: D S
authors: DS
authors: Ziablitsev
authors: O S
authors: OS
authors: Larin
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000483:Alleles; D015519:Bone Density; D002118:Calcium / Q000097:blood; D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific / Q000737:chemistry; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D008274:Magnesium / Q000097:blood; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000235:genetics* / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000097:blood; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000097:blood / Q000235:genetics; D011374:Progesterone / Q000097:blood*; D018167:Receptors, Calcitriol / Q000097:blood / Q000235:genetics*; D013739:Testosterone / Q000097:blood*
chemical_list: D053583:Interleukin-1beta; D010281:Parathyroid Hormone; D018167:Receptors, Calcitriol; C579457:VDR protein, human; D010758:Phosphorus; D013739:Testosterone; D011374:Progesterone; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases; D000469:Alkaline Phosphatase; D008274:Magnesium; D002118:Calcium