title: Pregnancy Outcome After I-131 Therapy for Patients With Thyroid Cancer: A Nationwide Population-Based Cohort Study.
abstract: The aim of this study was to evaluate the influence of I-131 therapy on pregnancy outcome in patients that received therapeutic I-131 doses for thyroid cancer in Taiwan.This nationwide population-based cohort study was based on data from 1998 to 2010 obtained from the Taiwanese National Health Insurance Research Database. We identified 11,708 women with thyroid cancer (≥ 15 and ≤ 50 years of age) by International Classification of Diseases, Ninth Revision, Clinical Modification codes. Patients were divided into 2 cohorts: I-131 therapy cohort and non-I-131 therapy cohort. The mean follow-up period was 6.08 years for the I-131 cohort and 6.87 years for the non-I-131 cohort. The case cohort and the control cohort comprised 775 and 716 pregnant patients, respectively.The overall incidence of pregnancy was significantly lower in the I-131 cohort (adjusted HR = 0.77, 95% CI = 0.70-0.86) and it was also observed when the patients were stratified according to age (HR = 0.73, 95% CI = 0.64-0.83 in 25-34 years; HR = 0.63, 95% CI = 0.49-0.82 in 35-44 years). Patients in the I-131 cohort had a lower successful delivery rate, particularly among patients in 25 to 34 years (OR = 0.60, 95% CI = 0.45-0.80). No significant difference was observed for adverse pregnancy conditions between 2 cohorts.I-131 therapy is associated with decreased pregnancy and successful delivery rates. The underlying mechanism likely involves physician recommendation, patient's psychological issue, and potential impact of I-131 treatment on reproductive health. Further investigation is needed.
authors: From the Department of Nuclear Medicine, National Taiwan University Hospital, Taipei (K-YK, R-FY, M-FC); Management Office for Health Data, China Medical University Hospital (C-LL); College of Medicine, China Medical University, Taichung (C-LL); Department of Radiology, National Taiwan University College of Medicine, (R-FY, M-FC); Department of Nuclear Medicine, Changhua Christian Hospital, Changhua, and Taipei Veteran General Hospital, Taipei (W-SH); Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University (C-HK); and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan, Republic of China (C-HK).
authors: Kuan-Yin
authors: KY
authors: Ko
authors: Ruoh-Fang
authors: RF
authors: Yen
authors: Cheng-Li
authors: CL
authors: Lin
authors: Mei-Fang
authors: MF
authors: Cheng
authors: Wen-Sheng
authors: WS
authors: Huang
authors: Chia-Hung
authors: CH
authors: Kao
mesh_terms: D000293:Adolescent; D000328:Adult; D002277:Carcinoma / Q000628:therapy*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D011247:Pregnancy; D011256:Pregnancy Outcome; D013964:Thyroid Neoplasms / Q000628:therapy*; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes