title: A new case of cervical intramedullary sinus histiocytosis causing paraplegia and review of the literature.
abstract: BACKGROUND
  Rosai-Dorfman disease (RDD) is an uncommon, benign histiocytic proliferative disorder of unknown origin. It predominantly affects the lymph nodes, but can also be found extranodal in different organs. Nervous system involvement is rare, and the most cases are intracranial. Surgical treatment is indicated when the central nervous system (CNS) in compromised.
  
  
  METHODS
  We herein describe the management of a 27-year-old woman who presented progressive spinal cord symptoms, secondary to an isolated intramedullary lesion, which had a histological confirmation of RDD. To our knowledge, this is the 6(th) case reported in English written manuscripts. We review these cases and analyze some of the literature concerning the disease.
  
  
  CONCLUSIONS
  RDD shows some variability in the involvement of the entire neuraxis, and because its ability to mimic meningeal and primary brain tumors, it is essential to be aware of this entity and consider RDD in the differential diagnosis of various lesions of the CNS. The conclusive diagnosis must be obtained by histological methods, so surgical approaches have to be discussed. Although it is not considered as a malignancy, options for postoperative medical treatment are variable and include radiation, chemotherapy or maybe monoclonal antibodies for refractory or recurrent cases.
authors: Department of Neurosurgery, Hospital General de Culiacán, Salvador Zubirán, México.
authors: Jesús
authors: J
authors: Rocha-Maguey
authors: Department of Neurosurgery, Hospital General de Culiacán, Salvador Zubirán, México.
authors: José-Angel
authors: JA
authors: Felix-Torrontegui
authors: Department of Anatomical Pathology, Hospital General de Culiacán, Salvador Zubirán, México.
authors: Myriam
authors: M
authors: Cabrera-López
authors: Department of Anatomical Pathologyl, Hospital Angeles de Culiacán Sinaloa, Salvador Zubirán, México.
authors: Macrina
authors: M
authors: Gutiérrez-Castro
authors: Department of Anatomical Pathology, Instituto Nacional de Ciencias Medicas y Nutrición, Salvador Zubirán, México.
authors: Daniel
authors: D
authors: Montante-Montes de Oca
keywords: Cervical; Rosai–Dorfman disease; sinus histiocytosis; spinal cord