title: Persistent Effect of Vitamin D Supplementation on Musculoskeletal Parameters in Adolescents One Year After Trial Completion.
abstract: We showed a beneficial effect of vitamin D supplementation on musculoskeletal parameters in adolescent girls in a 1-year, randomized, double-blinded placebo-controlled trial (RCT). Our objective for this study was to investigate the residual effect of vitamin D supplementation on bone mineral content (BMC), bone mineral density (BMD), at the lumbar spine and hip, lean mass, and height, 1 year after trial completion. We performed post hoc analyses in 167 adolescents, 86 girls and 81 boys, age 13.9 ± 2 years, who received vitamin D or placebo during the trial, and continued into the follow-up trial. Musculoskeletal parameters were measured at baseline, 12 months (intervention), and 24 months (follow-up). ANOVA and t tests were used to compare results between the placebo group and the merged vitamin D arms (200 or 2000 IU/day), by gender. Baseline characteristics were comparable between treatment groups at entry into the extension. Girls who had received vitamin D during the trial, had significantly larger hip BMC increments compared to those assigned to placebo, at 24 months compared to study entry, but not 24 compared to 12 months, which persisted in adjusted analyses. There were no significant differences in bone mass changes between treatment groups in boys, at 24 months compared to 12 months or to baseline. The beneficial effect of vitamin D supplementation on hip bone mass, achieved in girls during the trial, persisted 1 year after trial completion. These net cumulative increments, 1 year after discontinuation of supplementation, may have important implications on optimizing peak bone mass accretion in adolescent girls. © 2016 American Society for Bone and Mineral Research.
authors: American University of Beirut Medical Center (AUB-MC), Beirut, Lebanon.|Department of Internal Medicine, Division of Endocrinology, American University of Beirut Medical Center, Beirut, Lebanon.
authors: Nisrine
authors: N
authors: Ghazal
authors: American University of Beirut Medical Center (AUB-MC), Beirut, Lebanon.|Vascular Medicine Program, American University of Beirut Medical Center, Beirut, Lebanon.|Scholars in Health Research Program, American University of Beirut Medical Center, Beirut, Lebanon.
authors: Laila
authors: L
authors: Al-Shaar
authors: American University of Beirut Medical Center (AUB-MC), Beirut, Lebanon.|Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Beirut, Lebanon.
authors: Joyce
authors: J
authors: Maalouf
authors: American University of Beirut Medical Center (AUB-MC), Beirut, Lebanon.|Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors: Mona
authors: M
authors: Nabulsi
authors: American University of Beirut Medical Center (AUB-MC), Beirut, Lebanon.|Department of Internal Medicine, Division of Endocrinology, American University of Beirut Medical Center, Beirut, Lebanon.
authors: Asma
authors: A
authors: Arabi
authors: American University of Beirut Medical Center (AUB-MC), Beirut, Lebanon.|Department of Internal Medicine, Division of Endocrinology, American University of Beirut Medical Center, Beirut, Lebanon.
authors: Mahmoud
authors: M
authors: Choucair
authors: American University of Beirut Medical Center (AUB-MC), Beirut, Lebanon.
authors: Hani
authors: H
authors: Tamim
authors: Weill Cornell Medical College, Doha, Qatar.
authors: Ziad
authors: Z
authors: Mahfoud
authors: American University of Beirut Medical Center (AUB-MC), Beirut, Lebanon.|Department of Internal Medicine, Division of Endocrinology, American University of Beirut Medical Center, Beirut, Lebanon.|Scholars in Health Research Program, American University of Beirut Medical Center, Beirut, Lebanon.|Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Beirut, Lebanon.
authors: Ghada
authors: G
authors: El-Hajj Fuleihan
mesh_terms: D000293:Adolescent; D015519:Bone Density / Q000187:drug effects*; D002648:Child; D004311:Double-Blind Method; D005260:Female; D005270:Femur Head / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D041641:Musculoskeletal Development / Q000187:drug effects*; D012727:Sex Characteristics; D014807:Vitamin D / Q000008:administration & dosage*
chemical_list: D014807:Vitamin D
keywords: DXA; GENERAL POPULATION STUDIES; NUTRITION