title: Blunted neural responses to reward in remitted major depression: A high-density event-related potential study.
abstract: Major depressive disorder (MDD) is a highly recurrent condition, and improving our understanding of the abnormalities that persist in remitted MDD (rMDD) may provide insight into mechanisms that contribute to relapse. MDD has been characterized by reward learning deficits linked to dysfunction in frontostriatal regions. Although initial behavioral evidence of reward learning deficits in rMDD has recently emerged, it is unclear whether these reflect impairments in neural reward processing that persist into remission.
  
  
  
  We examined behavioral reward learning and 128-channel event-related potentials (ERP) during a well-validated probabilistic reward task in 26 rMDD individuals and 34 never-depressed controls. Temporo-spatial principal components analysis (PCA) was used to separate overlapping ERP components, and group differences in neural activity ina prioriregions were examined using low-resolution electromagnetic tomography (LORETA).
  
  
  
  Individuals with rMDD displayed reduced behavioral reward learning, as well as blunted ERP amplitude to reward feedback. Importantly, the reduction in ERP amplitude occurred at a PCA factor that peaked during the time at which phasic reward feedback-related signaling - hypothesized to originate in the striatum and project to the anterior cingulate cortex (ACC) - are thought to modulate scalp-recorded activity. Consistent with this, LORETA analyses revealed reduced activity in the ACC in the rMDD group, and this blunting correlated with poorer reward learning.
  
  
  
  These findings suggest that the reward learning impairment observed in acute MDD persists into full remission and that these impairments may be attributable to abnormalities in the neural processes that support reward feedback monitoring, particularly within the ACC.
authors: McLean Hospital & Harvard Medical School.
authors: Alexis E
authors: AE
authors: Whitton
authors: McLean Hospital & Harvard Medical School.
authors: Pragya
authors: P
authors: Kakani
authors: Purdue University.
authors: Dan
authors: D
authors: Foti
authors: McLean Hospital & Harvard Medical School.
authors: Ashlee
authors: A
authors: Van't Veer
authors: McLean Hospital & Harvard Medical School.
authors: Anja
authors: A
authors: Haile
authors: McLean Hospital & Harvard Medical School.
authors: David J
authors: DJ
authors: Crowley
authors: McLean Hospital & Harvard Medical School.
authors: Diego A
authors: DA
authors: Pizzagalli
keywords: ERP; anhedonia; anterior cingulate; feedback-related negativity; major depression; reward learning