title: Antidepressant-like Effect of Insulin in Streptozotocin-induced Type 2 Diabetes Mellitus Rats.
abstract: This study evaluated the antidepressant-like effect of insulin compared to sertraline and a combination of insulin and sertraline in streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) rats submitted to the forced swim test (FST). Male Wistar rats were daily treated for 21 days with insulin (1 or 2 IU/kg, i.p.), with the selective serotonin reuptake inhibitor (SSRI), sertraline (10 mg/kg, i.p.), or with a combination of insulin (1 or 2 IU/kg, i.p.) and sertraline (10 mg/kg, i.p.) and submitted to the FST. We also evaluated the water and food intake, urine volume and weight gain of the rats. Rats treated with STZ showed impaired glucose tolerance. Chronic treatment with sertraline showed an antidepressant-like effect in non-diabetic and diabetic rats. Furthermore, sertraline promoted lower weight gain in diabetic rats. Insulin reduced the immobility behaviour in T2DM rats with impaired glucose tolerance. In conclusion, our results showed that insulin has an antidepressant-like effect comparable to that of sertraline. Sertraline is effective as an antidepressant and reduces weight gain, which reinforces its superiority over other SSRIs in the treatment of major depression disorder in patients with T2DM.
authors: Department of Pharmacology and Therapeutics, State University of Maringa, Maringa, Brazil.
authors: Caio C
authors: CC
authors: Sestile
authors: Department of Pharmacology and Therapeutics, State University of Maringa, Maringa, Brazil.
authors: Jhonatan C
authors: JC
authors: Maraschin
authors: Department of Pharmacology and Therapeutics, State University of Maringa, Maringa, Brazil.
authors: Marcel P
authors: MP
authors: Rangel
authors: Department of Pharmacology and Therapeutics, State University of Maringa, Maringa, Brazil.
authors: Roberto K N
authors: RK
authors: Cuman
authors: Department of Pharmacology and Therapeutics, State University of Maringa, Maringa, Brazil.
authors: Elisabeth A
authors: EA
authors: Audi
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D018149:Glucose Intolerance / Q000188:drug therapy; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D020280:Sertraline / Q000494:pharmacology; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D001786:Blood Glucose; D007328:Insulin; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline