title: In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect.
abstract: In this communication the mismatch between simultaneous (18)F-FDG-PET and a (13)C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that (18)F-FDG-PET may not always reflect the Warburg effect in all tumors.
authors: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. gutte@sund.ku.dk.
authors: Henrik
authors: H
authors: Gutte
authors: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. adam.espe.hansen@regionh.dk.
authors: Adam E
authors: AE
authors: Hansen
authors: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 2000, Denmark. majbritt.larsen@sund.ku.dk.
authors: Majbrit M E
authors: MM
authors: Larsen
authors: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. sofie89falko@gmail.com.
authors: Sofie
authors: S
authors: Rahbek
authors: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. helle.hjorth.johannesen.01@regionh.dk.
authors: Helle H
authors: HH
authors: Johannesen
authors: Department of Electrical Engineering, Technical University of Denmark, Lyngby 2800, Denmark. JanHenrik.ArdenkjaerLarsen@ge.com.|GE Healthcare, Brøndby 2605, Denmark. JanHenrik.ArdenkjaerLarsen@ge.com.
authors: Jan
authors: J
authors: Ardenkjaer-Larsen
authors: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 2000, Denmark. atk@sund.ku.dk.
authors: Annemarie T
authors: AT
authors: Kristensen
authors: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. liselotte.hoejgaard@regionh.dk.
authors: Liselotte
authors: L
authors: Højgaard
authors: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. akjaer@sund.ku.dk.
authors: Andreas
authors: A
authors: Kjaer
keywords: 13C-pyruvate; 18F-FDG-PET; MR; PET/MR; cancer; dynamic nuclear polarization; hyperPET; hyperpolarized; molecular imaging