title: Detection of bone marrow involvement in newly diagnosed post-transplant lymphoproliferative disorder: (18)F-fluorodeoxyglucose positron emission tomography/computed tomography versus bone marrow biopsy.
abstract: Detecting bone marrow involvement (BMI) in lymphoma is important as it adversely affects stage. Bone marrow biopsy (BMB) remains the standard to detect BMI but is prone to sampling error. We retrospectively investigated whether (18)F-fluorodeoxyglucose positron emission tomography with computed tomography ((18)F-FDG-PET/CT) could identify BMI in patients with post-transplant lymphoproliferative disorder (PTLD) with sufficient accuracy in comparison with staging BMB. Twenty-five patients diagnosed with PTLD who underwent (18)F-FDG-PET/CT and BMB within one month were evaluated. Based on our criteria, six patients (24%) were considered positive for BMI on (18)F-FDG-PET/CT compared to one by BMB. Although we cannot completely exclude false positive results on (18)F-FDG-PET/CT, our data indicate a significantly higher sensitivity of (18)F-FDG-PET/CT compared to BMB (100% vs 17%) but similar specificity. These data confirm the high diagnostic performance of (18)F-FDG-PET/CT for detecting BMI, but prospective studies are needed to determine whether (18)F-FDG-PET/CT could indeed replace staging BMB in PTLD.
authors: a Nuclear Medicine and Molecular Imaging, University Hospitals Leuven, Belgium and Department of Imaging and Pathology, KU Leuven , Belgium ;
authors: Olivier
authors: O
authors: Gheysens
authors: a Nuclear Medicine and Molecular Imaging, University Hospitals Leuven, Belgium and Department of Imaging and Pathology, KU Leuven , Belgium ;
authors: Sanne
authors: S
authors: Thielemans
authors: b Department of Translational Cell and Tissue Research and Pathology , University Hospitals Leuven, KU Leuven , Belgium ;
authors: Julie
authors: J
authors: Morscio
authors: c Department of Laboratory Medicine , University Hospitals Leuven, Belgium and Department of Oncology, KU Leuven , Belgium ;
authors: Nancy
authors: N
authors: Boeckx
authors: a Nuclear Medicine and Molecular Imaging, University Hospitals Leuven, Belgium and Department of Imaging and Pathology, KU Leuven , Belgium ;
authors: Karolien E
authors: KE
authors: Goffin
authors: a Nuclear Medicine and Molecular Imaging, University Hospitals Leuven, Belgium and Department of Imaging and Pathology, KU Leuven , Belgium ;
authors: Christophe M
authors: CM
authors: Deroose
authors: b Department of Translational Cell and Tissue Research and Pathology , University Hospitals Leuven, KU Leuven , Belgium ;
authors: Xavier
authors: X
authors: Sagaert
authors: d Center for Human Genetics, KU Leuven , Belgium ;
authors: Iwona
authors: I
authors: Wlodarska
authors: e Department of Hematology , University Hospitals Leuven, KU Leuven , Belgium ;|f Department of Oncology , University Hospitals Leuven, KU Leuven , Belgium.
authors: Gregor
authors: G
authors: Verhoef
authors: e Department of Hematology , University Hospitals Leuven, KU Leuven , Belgium ;|f Department of Oncology , University Hospitals Leuven, KU Leuven , Belgium.
authors: Daan
authors: D
authors: Dierickx
authors: b Department of Translational Cell and Tissue Research and Pathology , University Hospitals Leuven, KU Leuven , Belgium ;
authors: Thomas
authors: T
authors: Tousseyn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000473:pathology*; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology; D002648:Child; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D009367:Neoplasm Staging; D016377:Organ Transplantation / Q000009:adverse effects*; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Bone marrow biopsy; FDG-PET/CT; PTLD; post-transplant lymphoproliferative disorder; transplantation