title: Characterization of Streptococcus pyogenes isolates responsible for adult meningitis in France from 2003 to 2013.
abstract: Sixty-three cases of Streptococcus pyogenes meningitis in adults were studied. Three predominant emm types were associated with meningitis: emm1 (44%), emm3 (11%), and emm6 (11%). Streptococcal toxic shock syndrome and mortality rates were 40% and 38%, respectively.
authors: Centre National de Référence des Streptocoques (CNR-Strep), Hôpitaux Universitaires Paris Centre, Cochin, Assistance Publique Hôpitaux de Paris, France; Faculté de Médecine, Université Paris Descartes, France; INSERM 1016, Institut Cochin, Paris, France; CNRS, UMR 8104, Paris, France.
authors: Céline
authors: C
authors: Plainvert
authors: Centre National de Référence des Streptocoques (CNR-Strep), Hôpitaux Universitaires Paris Centre, Cochin, Assistance Publique Hôpitaux de Paris, France.
authors: Alexandra
authors: A
authors: Doloy
authors: Centre National de Référence des Streptocoques (CNR-Strep), Hôpitaux Universitaires Paris Centre, Cochin, Assistance Publique Hôpitaux de Paris, France; Faculté de Médecine, Université Paris Descartes, France; INSERM 1016, Institut Cochin, Paris, France; CNRS, UMR 8104, Paris, France.
authors: Caroline
authors: C
authors: Joubrel
authors: Centre National de Référence des Streptocoques (CNR-Strep), Hôpitaux Universitaires Paris Centre, Cochin, Assistance Publique Hôpitaux de Paris, France.
authors: Naouale
authors: N
authors: Maataoui
authors: Centre National de Référence des Streptocoques (CNR-Strep), Hôpitaux Universitaires Paris Centre, Cochin, Assistance Publique Hôpitaux de Paris, France.
authors: Nicolas
authors: N
authors: Dmytruk
authors: Centre National de Référence des Streptocoques (CNR-Strep), Hôpitaux Universitaires Paris Centre, Cochin, Assistance Publique Hôpitaux de Paris, France.
authors: Gérald
authors: G
authors: Touak
authors: Centre National de Référence des Streptocoques (CNR-Strep), Hôpitaux Universitaires Paris Centre, Cochin, Assistance Publique Hôpitaux de Paris, France.
authors: Gislène
authors: G
authors: Collobert
authors: Centre National de Référence des Streptocoques (CNR-Strep), Hôpitaux Universitaires Paris Centre, Cochin, Assistance Publique Hôpitaux de Paris, France; Faculté de Médecine, Université Paris Descartes, France; INSERM 1016, Institut Cochin, Paris, France; CNRS, UMR 8104, Paris, France.
authors: Agnès
authors: A
authors: Fouet
authors: Centre National de Référence des Streptocoques (CNR-Strep), Hôpitaux Universitaires Paris Centre, Cochin, Assistance Publique Hôpitaux de Paris, France; Faculté de Médecine, Université Paris Descartes, France; INSERM 1016, Institut Cochin, Paris, France; CNRS, UMR 8104, Paris, France.
authors: Claire
authors: C
authors: Poyart
authors: Centre National de Référence des Streptocoques (CNR-Strep), Hôpitaux Universitaires Paris Centre, Cochin, Assistance Publique Hôpitaux de Paris, France; Faculté de Médecine, Université Paris Descartes, France. Electronic address: julien.loubinoux@aphp.fr.
authors: Julien
authors: J
authors: Loubinoux
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D016000:Cluster Analysis; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D012772:Shock, Septic / Q000453:epidemiology / Q000401:mortality*; D013290:Streptococcal Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D013297:Streptococcus pyogenes / Q000145:classification* / Q000302:isolation & purification*; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein
keywords: Group A Streptococcus; Meningitis; Multilocus sequence typing; Streptococcus pyogenes; emm cluster; emm type