title: gH/gL supercomplexes at early stages of herpesvirus entry.
abstract: Membrane fusion during herpesvirus entry into host cells is a complex process where multiple glycoproteins interact to relay the triggering signal from a receptor-binding protein to the conserved fusogen gB through the conserved heterodimer gH/gL. Crystal structures of individual glycoproteins are available, yet high-order 'supercomplexes' have been elusive. Recent structures of complexes between gH/gL from human cytomegalovirus or Epstein-Barr virus and the receptor-binding proteins that form at early stages of herpesviral entry highlighted mechanisms that control tropism and revealed dynamic intermediate complexes containing gH/gL that may directly participate in membrane deformation and juxtaposition. Determining how the triggering signal reaches the fusogen gB represents the next frontier in structural biology of herpesvirus entry.
authors: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: katya.heldwein@tufts.edu.
authors: Ekaterina E
authors: EE
authors: Heldwein
mesh_terms: D003587:Cytomegalovirus / Q000737:chemistry; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D006564:Herpesviridae / Q000737:chemistry* / Q000502:physiology*; D018258:Herpesvirus 2, Human / Q000737:chemistry; D004854:Herpesvirus 4, Human / Q000737:chemistry; D008561:Membrane Fusion; D008854:Microscopy, Electron; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000378:metabolism*; D056189:Viral Tropism; D053586:Virus Internalization
chemical_list: D006023:Glycoproteins; D046912:Multiprotein Complexes; D014759:Viral Envelope Proteins