title: Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates.
abstract: Elevated levels of the phosphate-regulating hormone, fibroblast growth factor-23 (FGF-23) are associated with skeletal and cardiovascular disease. Levels of FGF-23 are elevated in neonates, but the mechanisms are poorly understood. Iron deficiency is a recently described stimulus for FGF-23 production.
  
  
  
  To test the hypothesis that lower fetal iron status, as measured by lower cord blood ferritin, is independently associated with elevated FGF-23 levels in neonates.
  
  
  
  This is a cross-sectional study of 64 full-term, healthy neonates.
  
  
  
  This study took place in a university-based, tertiary care center.
  
  
  
  Plasma levels of second generation C-terminal FGF-23 (cFGF-23) and intact FGF-23 (iFGF-23).
  
  
  
  Levels of cFGF-23 ranged from 108 to 7508 reference units (RU)/ml (median, 824 RU/ml), and iFGF-23 from undetectable (<8.5) to 135.4 pg/ml (median, <8.5 pg/mL). Ferritin ranged from 58 to 719 ng/ml (mean, 203 ng/ml). Lower cord blood ferritin levels were associated with higher cFGF-23 (r = −0.320; P = .014), but not iFGF-23 levels (r = −0.222; P = .082). In multivariate analyses adjusted for glycemic indices, maternal race, and parity, lower ferritin levels remained independently associated with higher cFGF-23 levels (B = −0.261, P = .01). In the full models, higher cord blood glucose and C-peptide levels were also independently associated with higher cFGF-23 levels.
  
  
  
  cFGF-23, but not iFGF-23 levels, are elevated in cord blood of healthy term neonates and independently associated with lower serum ferritin and higher glycemic indices.
authors: Department of Pediatrics (F.N.A., J.J., K.M.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Center for Translational Metabolism and Health (F.N.A., M.W.), Institute for Public Health and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Department of Medicine (A.J.M.), Division of Endocrinology, Diabetes and Metabolism, and The Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33021; Division of Nephrology and Hypertension (M.W.), Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
authors: Farah N
authors: FN
authors: Ali
authors: Department of Pediatrics (F.N.A., J.J., K.M.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Center for Translational Metabolism and Health (F.N.A., M.W.), Institute for Public Health and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Department of Medicine (A.J.M.), Division of Endocrinology, Diabetes and Metabolism, and The Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33021; Division of Nephrology and Hypertension (M.W.), Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
authors: Jami
authors: J
authors: Josefson
authors: Department of Pediatrics (F.N.A., J.J., K.M.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Center for Translational Metabolism and Health (F.N.A., M.W.), Institute for Public Health and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Department of Medicine (A.J.M.), Division of Endocrinology, Diabetes and Metabolism, and The Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33021; Division of Nephrology and Hypertension (M.W.), Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
authors: Armando J
authors: AJ
authors: Mendez
authors: Department of Pediatrics (F.N.A., J.J., K.M.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Center for Translational Metabolism and Health (F.N.A., M.W.), Institute for Public Health and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Department of Medicine (A.J.M.), Division of Endocrinology, Diabetes and Metabolism, and The Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33021; Division of Nephrology and Hypertension (M.W.), Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
authors: Karen
authors: K
authors: Mestan
authors: Department of Pediatrics (F.N.A., J.J., K.M.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Center for Translational Metabolism and Health (F.N.A., M.W.), Institute for Public Health and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Department of Medicine (A.J.M.), Division of Endocrinology, Diabetes and Metabolism, and The Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33021; Division of Nephrology and Hypertension (M.W.), Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
authors: Myles
authors: M
authors: Wolf
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D005293:Ferritins / Q000097:blood*; D005312:Fetal Blood / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D007087:Illinois / Q000453:epidemiology; D007231:Infant, Newborn; D007501:Iron / Q000378:metabolism*; D055815:Young Adult
chemical_list: C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005293:Ferritins; D007501:Iron