title: Biological Evaluation of Ferrocenyl Olefins: Cancer Cell Growth Inhibition, ROS Production, and Apoptosis Activity.
abstract: The antiproliferative effects of various ferrocenyl olefins were evaluated against the cell lines MCF-7 (human breast cancer cells), DLD-1 (human colon adenocarcinoma cells), HUVEC (human umbilical vein endothelial cells), and A549 (human lung carcinoma cells), using the MTT test. IC50 values were determined. Compounds 8, 9, 11, and 12 with high antiproliferative activity were tested for their reactive oxygen species (ROS) production, and cell cycle analysis was performed on A549 cells. The results show that these compounds might perform their antiproliferative activity through inducing ROS generation, apoptosis induction, and cell cycle arrest.
authors: School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou, P. R. China.
authors: Aijing
authors: A
authors: Sun
authors: School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou, P. R. China.
authors: Junsheng
authors: J
authors: Lin
authors: Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou, P. R. China.
authors: Chao
authors: C
authors: Pi
authors: School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou, P. R. China.
authors: Ruian
authors: R
authors: Xu
authors: School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou, P. R. China.|Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou, P. R. China.
authors: Xiuling
authors: X
authors: Cui
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D000075163:Metallocenes; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; D005296:Ferrous Compounds; D000075163:Metallocenes; D017382:Reactive Oxygen Species; C004998:ferrocene
keywords: Cell cycle arrest; Cytotoxicity; Ferrocenyl olefin; Reactive oxygen species; Structure-activity relationship