title: Dried plum diet protects from bone loss caused by ionizing radiation.
abstract: Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation increases oxidative damage in skeletal tissues, and results in an imbalance in bone remodeling initiated by increased bone-resorbing osteoclasts. Therefore, we evaluated various candidate interventions with antioxidant or anti-inflammatory activities (antioxidant cocktail, dihydrolipoic acid, ibuprofen, dried plum) both for their ability to blunt the expression of resorption-related genes in marrow cells after irradiation with either gamma rays (photons, 2 Gy) or simulated space radiation (protons and heavy ions, 1 Gy) and to prevent bone loss. Dried plum was most effective in reducing the expression of genes related to bone resorption (Nfe2l2, Rankl, Mcp1, Opg, TNF-α) and also preventing later cancellous bone decrements caused by irradiation with either photons or heavy ions. Thus, dietary supplementation with DP may prevent the skeletal effects of radiation exposures either in space or on Earth.
authors: Bone and Signaling Laboratory, Space Biosciences Division, NASA Ames Research Center.
authors: A-S
authors: AS
authors: Schreurs
authors: Bone and Signaling Laboratory, Space Biosciences Division, NASA Ames Research Center.
authors: Y
authors: Y
authors: Shirazi-Fard
authors: Bone and Signaling Laboratory, Space Biosciences Division, NASA Ames Research Center.
authors: M
authors: M
authors: Shahnazari
authors: Bone and Signaling Laboratory, Space Biosciences Division, NASA Ames Research Center.
authors: J S
authors: JS
authors: Alwood
authors: Bone and Signaling Laboratory, Space Biosciences Division, NASA Ames Research Center.
authors: T A
authors: TA
authors: Truong
authors: Bone and Signaling Laboratory, Space Biosciences Division, NASA Ames Research Center.
authors: C G T
authors: CG
authors: Tahimic
authors: Department of Radiation Oncology, University of California Irvine.
authors: C L
authors: CL
authors: Limoli
authors: Department of Nutrition and Food Science, Texas A&M University.
authors: N D
authors: ND
authors: Turner
authors: Department of Medicine, Division of Endocrinology, University of California San Francisco.
authors: B
authors: B
authors: Halloran
authors: Bone and Signaling Laboratory, Space Biosciences Division, NASA Ames Research Center.
authors: R K
authors: RK
authors: Globus
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D019587:Dietary Supplements; D005638:Fruit; D005720:Gamma Rays / Q000009:adverse effects*; D005786:Gene Expression Regulation / Q000528:radiation effects*; D008297:Male; D051379:Mice; D000068242:Prunus domestica; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control