title: COMPARISON OF PRE-EMPTIVE EFFECT OF MELOXICAM AND CELECOXCIB ON POST-OPERATIVE ANALGESIA: A DOUBLE-BLIND, RANDOMIZED CLINICAL TRIAL.
abstract: BACKGROUND
  Pre-emptive analgesia may reduce pain, accelerate recovery and shorten the duration of hospitalization. The present study aims to compare the preemptive analgesic effects of meloxicam and celecoxib in patients undergoing lower limb surgery.
  
  
  METHODS
  In this double blind randomized clinical trial, 70 patients, undergoing lower extremity surgery, entered in the study; thirty five patients were randomly allocated to either group using random allocation software. Meloxicam (15 mg) was administered orally to one group two hours before the surgical onset. The other group was treated with oral celecoxib (400 mg) two hours before the operation. Pain severity was compared between the two groups.
  
  
  RESULTS
  Upon admission to Recovery Room, the mean pain severity was not significantly different between the two groups. At one and two hours following surgery the mean pain severity was significantly higher in celecoxib group. However, 6 hours following surgery mean pain severity was higher with meloxicam administration. Pain severity was not significantly different in the two groups, 12 and 24 hours following surgery.
  
  
  CONCLUSIONS
  The analgesic effect of celecoxib seems to cover longer duration than meloxicam; but, meloxicam appears to be a stronger analgesic in shorter time interval.
authors: Omid
authors: O
authors: Aghadavoudi
authors: Hamid Hajigholam
authors: HH
authors: Saryazdi
authors: Amir
authors: A
authors: Shafa
authors: Alireza
authors: A
authors: Ramezani
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D000068579:Celecoxib / Q000008:administration & dosage* / Q000627:therapeutic use; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D000077239:Meloxicam; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D012720:Severity of Illness Index; D013843:Thiazines / Q000008:administration & dosage* / Q000627:therapeutic use; D013844:Thiazoles / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D013843:Thiazines; D013844:Thiazoles; D000068579:Celecoxib; D000077239:Meloxicam