title: Development and Validation of an HIV Risk Exposure and Indicator Conditions Questionnaire to Support Targeted HIV Screening.
abstract: The aim of our study was to develop a Spanish-structured HIV risk of exposure and indicator conditions (RE&IC) questionnaire. People attending to an emergency room or to a primary clinical care center were offered to participate in a prospective, 1 arm, open label study, in which all enrolled patients filled out our developed questionnaire and were HIV tested. Questionnaire accuracy, feasibility, and reliability were evaluated.Valid paired 5329 HIV RE&IC questionnaire and rapid HIV tests were performed, 69.3% in the primary clinical care center, 49.6% women, median age 37 years old, 74.9% Spaniards, 20.1% Latin-Americans. Confirmed hidden HIV infection was detected in 4.1%, while HIV RE&IC questionnaire was positive in 51.2%. HIV RE&IC questionnaire sensitivity was 100% to predict HIV infection, with a 100% negative predictive value. When considered separately, RE or IC items sensitivity decreases to 86.4% or 91%, and similarly their negative predictive value to 99.9% for both of them. The majority of people studied, 90.8% self-completed HIV RE&IC questionnaire. Median time to complete was 3 minutes. Overall HIV RE&IC questionnaire test-retest Kappa agreement was 0.82 (almost perfect), likewise for IC items 0.89, while for RE items was lower 0.78 (substantial).A feasible and reliable Spanish HIV RE&IC self questionnaire accurately discriminated all non-HIV-infected people without missing any HIV diagnoses, in a low prevalence HIV infection area. The best accuracy and reliability were obtained when combining HIV RE&IC items.
authors: From the Infectious Diseases Department (MJPE, CG-A, ADDS, AM, GR, CQ, FD, JLC, SM), Ramón y Cajal Hospital, IRYCIS; Centro de Salud García Noblejas (PPE, CS, LP, RB, AU, ACE), IRYCIS; Biostatistics Unit (AM), Ramón y Cajal Hospital, IRYCIS; CIBER de Epidemiología y Salud Pública (CIBERESP) (AM), Universidad Autónoma de Madrid; Facultad de Económicas y Administración de Empresas, Departamento de Economía Aplicada (AM); and Hospital de La Moraleja (MM-C), Sanitas, Madrid, Spain.
authors: María Jesús
authors: MJ
authors: Pérez Elías
authors: Cristina
authors: C
authors: Gómez-Ayerbe
authors: Pilar
authors: P
authors: Pérez Elías
authors: Alfonso
authors: A
authors: Muriel
authors: Santiago Diaz de
authors: SD
authors: Alberto
authors: María
authors: M
authors: Martinez-Colubi
authors: Ana
authors: A
authors: Moreno
authors: Cristina
authors: C
authors: Santos
authors: Lidia
authors: L
authors: Polo
authors: Rafa
authors: R
authors: Barea
authors: Gema
authors: G
authors: Robledillo
authors: Almudena
authors: A
authors: Uranga
authors: Cano Espín
authors: CE
authors: Agustina
authors: Carmen
authors: C
authors: Quereda
authors: Fernando
authors: F
authors: Dronda
authors: Jose Luis
authors: JL
authors: Casado
authors: Santiago
authors: S
authors: Moreno
mesh_terms: D000328:Adult; D000068598:Data Accuracy; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000517:prevention & control; D006630:Hispanic or Latino; D006801:Humans; D007802:Language; D008297:Male; D008403:Mass Screening / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D011795:Surveys and Questionnaires / Q000592:standards*