title: Potential roles of telocytes in lung diseases.
abstract: Telocytes (TCs) are a unique type of interstitial cells with specific, extremely long prolongations named telopodes (Tps), as shown by immune-positive staining against CD34, c-kit and vimentin. They were found in many organs of mammals, with potential biological functions, including the trachea and lung, even though the exact function remains unclear. Here, we give a historical overview of the TCs research field and summarize the latest findings associated with TCs, with a special focus on the recent progress about TCs specific gene and protein profiles that has been made in understanding that TCs may play a potential, but important, role in the pathogenesis of lung diseases.
authors: Zhongshan Hospital, Shanghai Institute of Clinical Bioinformatics; Fudan University Center for Clinical Bioinformatics, Biomedical Research Center of Fudan University Zhongshan Hospital, Shanghai, 200000, China.
authors: Lin
authors: L
authors: Shi
authors: Department of Pulmonary Medicine, The First affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
authors: Nian
authors: N
authors: Dong
authors: Department of Pulmonary Medicine, The First affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, China. Electronic address: chenchengshui1@126.com.
authors: Chengshui
authors: C
authors: Chen
authors: Zhongshan Hospital, Shanghai Institute of Clinical Bioinformatics; Fudan University Center for Clinical Bioinformatics, Biomedical Research Center of Fudan University Zhongshan Hospital, Shanghai, 200000, China. Electronic address: xiangdong.wang@clintransmed.org.
authors: Xiangdong
authors: X
authors: Wang
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D008171:Lung Diseases / Q000473:pathology*; D008954:Models, Biological; D000067170:Telocytes / Q000378:metabolism / Q000473:pathology*
keywords: Telocytes; gene; lung diseases; pathogenesis; protein