title: Migraine and endothelial function: The HUNT3 Study.
abstract: BACKGROUND
  Reduced endothelial function is associated with elevated risk of cardiovascular disease, but evidence on the association between migraine and endothelial function is conflicting. The aim of this population-based study was to examine the relationship between flow-mediated dilatation (FMD) and migraine with aura, migraine without aura and tension-type headache.
  
  
  METHODS
  In the third Nord-Trøndelag Healthy Study (HUNT3) FMD was measured by ultrasound during reactive hyperaemia of the brachial artery in a sample of 4739 healthy adult participants, 3929 of whom answered headache questions. The cross-sectional association between different headache diagnoses and FMD was evaluated by logistic regression, using a categorical approach.
  
  
  RESULTS
  Mean FMD did not differ between the headache groups and headache-free controls. In multi-adjusted analyses, no consistent association was found between FMD quintiles and headache groups.
  
  
  CONCLUSIONS
  There was no relationship between FMD and migraine or other headache diagnoses in this large cross-sectional study of otherwise healthy respondents including freedom from pulmonary and cardiovascular diseases.
authors: Department of Neuroscience, Norwegian University of Science and Technology, Norway.
authors: Joakim Schjølberg
authors: JS
authors: Larsen
authors: K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway.
authors: Eli-Anne
authors: EA
authors: Skaug
authors: K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway.|Department of Cardiology, St. Olavs Hospital, Norway.
authors: Ulrik
authors: U
authors: Wisløff
authors: K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway.|Department of Cardiology, St. Olavs Hospital, Norway.
authors: Øyvind
authors: Ø
authors: Ellingsen
authors: Department of Neuroscience, Norwegian University of Science and Technology, Norway.|Norwegian Advisory Unit on Headaches, St Olavs Hospital, Norway.
authors: Lars Jacob
authors: LJ
authors: Stovner
authors: Department of Neuroscience, Norwegian University of Science and Technology, Norway.|Norwegian Advisory Unit on Headaches, St Olavs Hospital, Norway.
authors: Mattias
authors: M
authors: Linde
authors: Department of Neuroscience, Norwegian University of Science and Technology, Norway knut.hagen@ntnu.no.|Norwegian Advisory Unit on Headaches, St Olavs Hospital, Norway.
authors: Knut
authors: K
authors: Hagen
mesh_terms: D000328:Adult; D000368:Aged; D001916:Brachial Artery / Q000473:pathology / Q000502:physiology; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000473:pathology* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D009664:Norway / Q000453:epidemiology; D011159:Population Surveillance / Q000379:methods; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Migraine; endothelial dysfunction; endothelial function; flow-mediated dilatation; headache