title: Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications.
abstract: Post-translational modifications (PTMs) produce significant changes in the structural properties of intrinsically disordered proteins (IDPs) by affecting their energy landscapes. PTMs can induce a range of effects, from local stabilization or destabilization of transient secondary structure to global disorder-to-order transitions, potentially driving complete state changes between intrinsically disordered and folded states or dispersed monomeric and phase-separated states. Here, we discuss diverse biological processes that are dependent on PTM regulation of IDPs. We also present recent tools for generating homogenously modified IDPs for studies of PTM-mediated IDP regulatory mechanisms.
authors: From the Program in Molecular Structure & Function, The Hospital for Sick Children, Toronto, Ontario M5G 0A4 and the Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada alaji.bah@sickkids.ca.
authors: Alaji
authors: A
authors: Bah
authors: From the Program in Molecular Structure & Function, The Hospital for Sick Children, Toronto, Ontario M5G 0A4 and the Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada forman@sickkids.ca.
authors: Julie D
authors: JD
authors: Forman-Kay
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D002843:Chromatin; D039642:Eukaryotic Initiation Factors / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D005164:Factor IX / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006657:Histones; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D064267:Intrinsically Disordered Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D017510:Protein Folding; D054730:Protein Interaction Domains and Motifs; D011499:Protein Processing, Post-Translational; D017433:Protein Structure, Secondary; D055672:Static Electricity; D013816:Thermodynamics
chemical_list: D000596:Amino Acids; D002843:Chromatin; C104151:EIF4EBP2 protein, human; D039642:Eukaryotic Initiation Factors; D006657:Histones; D064267:Intrinsically Disordered Proteins; D005164:Factor IX
keywords: intrinsically disordered protein; post-translational modification (PTM); protein conformation; protein-DNA interaction; protein-protein interaction; regulation