title: Antineoplastic agents and thrombotic microangiopathy.
abstract: Thrombotic microangiopathy is an uncommon but reported adverse effect of a variety of antineoplastic drugs, including chemotherapy agents such as mitomycin C and gemcitabine, and newer targeted agents such as the vascular endothelial growth factor inhibitors. We present a review of thrombotic microangiopathy associated with antineoplastic agents and its implications in current cancer therapy.
authors: Department of Medicine, Division of Hematology/Oncology, Staten Island University Hospital, Staten Island, NY, USA.
authors: Gwenalyn
authors: G
authors: Garcia
authors: Department of Medicine, Division of Hematology/Oncology, Staten Island University Hospital, Staten Island, NY, USA.
authors: Jean Paul
authors: JP
authors: Atallah
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects / Q000627:therapeutic use; D015994:Incidence; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use; D016685:Mitomycin / Q000009:adverse effects / Q000627:therapeutic use; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D009369:Neoplasms / Q000188:drug therapy*; D061988:Proteasome Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects; D057049:Thrombotic Microangiopathies / Q000139:chemically induced* / Q000453:epidemiology; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000378:metabolism; D000093542:Gemcitabine
chemical_list: D000970:Antineoplastic Agents; D007155:Immunologic Factors; D016898:Interferon-alpha; D061988:Proteasome Inhibitors; D042461:Vascular Endothelial Growth Factor A; D003841:Deoxycytidine; D016685:Mitomycin; D000093542:Gemcitabine
keywords: Chemotherapy; hemolytic uremic syndrome; thrombotic microangiopathy; thrombotic thrombocytopenic purpura