title: The contribution of genomics to the study of Q fever.
abstract: Coxiella burnetii is the etiological agent of Q fever, a worldwide zoonosis that can result in large outbreaks. The birth of genomics and sequencing of C. burnetii strains has revolutionized many fields of study of this infection. Accurate genotyping methods and comparative genomic analysis have enabled description of the diversity of strains around the world and their link with pathogenicity. Genomics has also permitted the development of qPCR tools and axenic culture medium, facilitating the diagnosis of Q fever. Moreover, several pathophysiological mechanisms can now be predicted and therapeutic strategies can be determined thanks to in silico genome analysis. An extensive pan-genomic analysis will allow for a comprehensive view of the clonal diversity of C. burnetii and its link with virulence.
authors: Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
authors: Felicetta
authors: F
authors: D'Amato
authors: Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
authors: Carole
authors: C
authors: Eldin
authors: Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
authors: Didier
authors: D
authors: Raoult
mesh_terms: D000818:Animals; D061245:Axenic Culture; D003198:Computer Simulation; D016997:Coxiella burnetii / Q000235:genetics* / Q000472:pathogenicity; D004196:Disease Outbreaks; D014644:Genetic Variation; D016680:Genome, Bacterial; D023281:Genomics; D005838:Genotype; D006801:Humans; D051379:Mice; D010802:Phylogeny; D011778:Q Fever / Q000175:diagnosis / Q000382:microbiology* / Q000503:physiopathology / Q000628:therapy; D060888:Real-Time Polymerase Chain Reaction; D014774:Virulence / Q000235:genetics; D015047:Zoonoses
keywords: Coxiella burnetii; Q fever; genomics; pan-genome; virulence