title: Inherited ion channel diseases: a brief review.
abstract: Ion channelopathies are diseases caused by dysfunctional ion channels that may lead to sudden death. These diseases can be either acquired or inherited. The main phenotypes observed in patients carrying these heritable arrhythmia syndromes are congenital long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome. In the recent years, tremendous progress has been made in the recognition, mechanisms, and treatment of these diseases. The goal of this review is to provide an overview of the main phenotypes, genetic underpinnings, risk stratification, and treatment options for these so-called cardiac ion channelopathies.
authors: Heart Centre, Department of Clinical and Experimental Cardiology, Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
authors: Krystien V V
authors: KV
authors: Lieve
authors: Heart Centre, Department of Clinical and Experimental Cardiology, Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Kingdom of Saudi Arabia a.a.wilde@amc.uva.nl.
authors: Arthur A M
authors: AA
authors: Wilde
mesh_terms: D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D053447:Channelopathies / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D010346:Patient Care Management / Q000379:methods
chemical_list: D007473:Ion Channels
keywords: Genetic; Inherited channelopathies; Sudden death