title: Insulin-Like Growth Factor Binding Proteins--an Update.
abstract: The insulin-like growth factor (IGF) system is essential for normal growth and development, and its perturbation is implicated in a number of diseases. IGF activity is finely regulated by a family of six high-affinity IGF binding proteins (IGFBPs). 1GFBPs usually inhibit IGF actions but may enhance them under certain conditions. Additionally, IGFBPs bind non-IGF ligands in the extracellular space, cell membrane, cytoplasm and nucleus, thereby modulating cell proliferation, survival and migration in an IGF-independent manner. IGFBP activity is regulated by transcriptional mechanisms as well as by post-translational modifications and proteolysis. Understanding the balance between the various actions of IGFBPs in vivo may lead to novel insights into disease processes and possible IGFBP-based therapeutics.
authors: Leon A
authors: LA
authors: Bach
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena / Q000502:physiology; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000737:chemistry / Q000502:physiology; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000737:chemistry / Q000502:physiology; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000737:chemistry / Q000502:physiology; D018974:Insulin-Like Growth Factor Binding Protein 4 / Q000737:chemistry / Q000502:physiology; D018975:Insulin-Like Growth Factor Binding Protein 5 / Q000737:chemistry / Q000502:physiology; D018976:Insulin-Like Growth Factor Binding Protein 6 / Q000737:chemistry / Q000502:physiology; D018969:Insulin-Like Growth Factor Binding Proteins / Q000737:chemistry / Q000502:physiology; D015394:Molecular Structure; D013002:Somatomedins / Q000502:physiology
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D018974:Insulin-Like Growth Factor Binding Protein 4; D018975:Insulin-Like Growth Factor Binding Protein 5; D018976:Insulin-Like Growth Factor Binding Protein 6; D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins