title: Mitochondria-Targeted Vitamin E Protects Skin from UVB-Irradiation.
abstract: Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated the protective effect of MVE against UVB in dermal fibroblasts and immortalized human keratinocyte cell line (HaCaT). In addition, we studied the wound-healing effect of MVE in animal models. We found that MVE increased the proliferation and survival of fibroblasts at low concentration (i.e., nM ranges). In addition, MVE increased collagen production and downregulated matrix metalloproteinase1. MVE also increased the proliferation and survival of HaCaT cells. UVB increased reactive oxygen species (ROS) production in fibroblasts and HaCaT cells, while MVE decreased ROS production at low concentration. In an animal experiment, MVE accelerated wound healing from laser-induced skin damage. These results collectively suggest that low dose MVE protects skin from UVB irradiation. Therefore, MVE can be developed as a cosmetic raw material.
authors: Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea.
authors: Won-Serk
authors: WS
authors: Kim
authors: College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.
authors: Ikyon
authors: I
authors: Kim
authors: College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.
authors: Wang-Kyun
authors: WK
authors: Kim
authors: Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea.
authors: Ju-Yeon
authors: JY
authors: Choi
authors: College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.
authors: Doo Yeong
authors: DY
authors: Kim
authors: College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.
authors: Sung-Guk
authors: SG
authors: Moon
authors: Cleanup Dermatologic Clinic, Seoul 07301, Republic of Korea.
authors: Hyung-Keun
authors: HK
authors: Min
authors: Cleanup Dermatologic Clinic, Seoul 07301, Republic of Korea.
authors: Min-Kyu
authors: MK
authors: Song
authors: College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.
authors: Jong-Hyuk
authors: JH
authors: Sung
keywords: Collagen; Fibroblast; HaCaT; Mitochondria-Targeted vitamin E; UVB protection