title: Parkinson's Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to α-Synuclein Oligomer.
abstract: OBJECTIVE
  The aim of this study was to identify the clinical characteristics and potential mechanisms relevant to pathological proteins in Parkinson's disease (PD) patients who experience fatigue.
  
  
  METHODS
  PD patients (n=102) were evaluated using a fatigue severity scale and scales for motor and nonmotor symptoms. The levels of three pathological proteins-α-synuclein oligomer, β-amyloid (Aβ)₁₋₄₂, and tau-were measured in 102 cerebrospinal fluid (CSF) samples from these PD patients. Linear regression analyses were performed between fatigue score and the CSF levels of the above-listed pathological proteins in PD patients.
  
  
  RESULTS
  The frequency of fatigue in the PD patients was 62.75%. The fatigue group had worse motor symptoms and anxiety, depression, and autonomic dysfunction. The CSF level of α-synuclein oligomer was higher and that of Aβ₁₋₄₂ was lower in the fatigue group than in the non-fatigue group. In multiple linear regression analyses, fatigue severity was significantly and positively correlated with the α-synuclein oligomer level in the CSF of PD patients, after adjusting for confounders.
  
  
  CONCLUSIONS
  PD patients experience a high frequency of fatigue. PD patients with fatigue have worse motor and part nonmotor symptoms. Fatigue in PD patients is associated with an increased α-synuclein oligomer level in the CSF.
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Li Jun
authors: LJ
authors: Zuo
authors: Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Shu Yang
authors: SY
authors: Yu
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Fang
authors: F
authors: Wang
authors: Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Yang
authors: Y
authors: Hu
authors: Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Ying Shan
authors: YS
authors: Piao
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Yang
authors: Y
authors: Du
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Teng Hong
authors: TH
authors: Lian
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Rui Dan
authors: RD
authors: Wang
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Qiu Jin
authors: QJ
authors: Yu
authors: Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Ya Jie
authors: YJ
authors: Wang
authors: Department of Physiology, Capital Medical University, Beijing, China.
authors: Xiao Min
authors: XM
authors: Wang
authors: Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China.|Department of Neurobiology, Beijing Xuanwu Hospital, Capital Medical University, Beijing, China.
authors: Piu
authors: P
authors: Chan
authors: Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: Sheng Di
authors: SD
authors: Chen
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.
authors: Yongjun
authors: Y
authors: Wang
authors: Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Beijing Key Laboratory on Parkinson's Disease, Beijing, China. ttyyzw@163.com.
authors: Wei
authors: W
authors: Zhang
keywords: Parkinson's disease; cerebrospinal fluid; fatigue; motor symptoms; nonmotor symptoms; α-synuclein oligomer