title: Mitochondrial Damage Induces Senescence with a Twisted Arm.
abstract: Cellular senescence is a damage response characterized by a stable cell-cycle arrest and an intense secretion of cytokines. In this issue of Cell Metabolism, Wiley et al. (2016) report that, in the case of mitochondrial damage, senescence occurs with an atypical secretory phenotype, in both adipose tissue and skin.
authors: Bioactive Products and Metabolic Syndrome Group, Madrid Institute of Advanced Studies (IMDEA) Food, Madrid E28049, Spain. Electronic address: pablojose.fernandez@imdea.org.
authors: Pablo J
authors: PJ
authors: Fernandez-Marcos
authors: Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address: mserrano@cnio.es.
authors: Manuel
authors: M
authors: Serrano
mesh_terms: D001132:Arm; D059447:Cell Cycle Checkpoints; D016922:Cellular Senescence; D004249:DNA Damage; D006801:Humans; D010641:Phenotype