title: Contribution of Hepatitis B to Long-Term Outcome Among Patients With Acute Myocardial Infarction: A Nationwide Study.
abstract: Although a possible association between hepatitis B and cardiovascular disease has been identified, the impact of viral hepatitis B on long-term prognosis after an acute myocardial infarction (AMI) is uncertain. Therefore, the aim of our study was to evaluate the specific impact of viral hepatitis B on survival after a first AMI through a retrospective analysis of data from the Taiwan National Health Insurance Research Database.This was a nationwide, propensity score-matched case-control study of patients admitted to hospitals between January 2000 and December 2012 with a primary diagnosis of a first AMI. Among the 7671 prospective patients, 244 patients with a confirmed diagnosis of viral hepatitis B infection were identified. A propensity score, one-to-one matching technique was used to match 244 controls to the AMI group for analysis. Controls were matched on the following variables: sex, age, hypertension, dyslipidemia, diabetes, peripheral vascular disease, heart failure, cerebrovascular accidents, end-stage renal disease, chronic obstructive pulmonary disease, and percutaneous coronary intervention (PCI).Overall, viral hepatitis B infection did not influence the 12-year survival rate (P = 0.98). However, survival was lower in female patients with viral hepatitis B infection compared to those without (P = 0.03; hazard ratio, 1.79; 95% confidence interval, 1.08-2.94). Inclusion of percutaneous coronary management improved survival, independent of sex, age, or hepatitis B status.Hepatitis B infection might increase the mortality risk of female patients after a first AMI. PCI may improve the long-term survival of patients after a first AMI, regardless of sex, age, and hepatitis B status.
authors: From the Critical Care Center and Cardiovascular Medical Center, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (P-LK, K-C L, P-LT, C-CC, W-CH, C-HC, H-CL, T-JC, S-RW, G-YM, C-PL); School of Medicine, National Yang-Ming University, Taipei, Taiwan (P-LK, C-CC, W-CH, C-HC, C-PL); Department of Physical Therapy, Fooyin University, Kaohsiung, Taiwan (C-CC, W-CH, C-HC); and Section of Gastroenterology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (J-SC).
authors: Pei-Lun
authors: PL
authors: Kuo
authors: Kun-Chang
authors: KC
authors: Lin
authors: Pei-Ling
authors: PL
authors: Tang
authors: Chin-Chang
authors: CC
authors: Cheng
authors: Wei-Chun
authors: WC
authors: Huang
authors: Cheng-Hung
authors: CH
authors: Chiang
authors: Hsiao-Chin
authors: HC
authors: Lin
authors: Tzu-Jung
authors: TJ
authors: Chuang
authors: Shue-Ren
authors: SR
authors: Wann
authors: Guang-Yuan
authors: GY
authors: Mar
authors: Jin-Shiung
authors: JS
authors: Cheng
authors: Chun-Peng
authors: CP
authors: Liu
mesh_terms: D000368:Aged; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000401:mortality; D012189:Retrospective Studies; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology