title: Psychometric Properties of Prodromal Questionnaire-Brief Version among Chinese Help-Seeking Individuals.
abstract: Prodromal Questionnaire (PQ) and Structured Interview for Prodromal Syndromes (SIPS) have been used as a two-stage process for identifying subjects at clinical high risk (CHR) of psychosis. The Prodromal Questionnaire-Brief version (PQ-B) contains 21 items derived from the PQ. The present study aimed to examine the psychometric properties of PQ-B in a Chinese help-seeking outpatient sample and to explore which items can better predict CHR diagnosis by SIPS and future transition to psychosis. In our preliminary epidemiological study, 1461 patients from a pool of 2101 individuals (15-45 years of age) completed the two-stage process. In the present study, 239 (20%) people were randomly selected among the sample who met the initial PQ-B screening criteria but had no positive diagnosis on SIPS, as well as 72 individuals with negative results on both PQ-B and SIPS, 89 prodromal and 105 psychotic subjects, yielding a total of 505 participants. The internal consistency coefficient for the PQ-B was good, with a Cronbach's alpha of 0.897. The concordant validity of PQ-B with SIPS dichotomized diagnosis of prodrome/psychosis versus no psychosis was 0.54. To ensure 80% or a higher sensitivity and a certain specificity, 7 and 24 were respectively set as the cutoff points for the PQ-B total score and distress score for Chinese help-seeking outpatients. A logistic regression model based on six PQ-B items could allow predicting the psychotic diagnosis on SIPS, with an accuracy of 65.8%. Prodromal individuals who scored higher on the 12th item of PQ-B (Do you worry at times that something may be wrong with your mind?) were less likely to convert to psychosis. PQ-B is a useful instrument for screening CHR subjects, but the cutoff score may be higher than that recommended by the author scores for help-seeking individuals in outpatient clinics. Some specific PQ-B items may have significant predictive power on dichotomized SIPS diagnoses and deserve special attention from researchers in future studies.
authors: Shanghai Key Laboratory of Psychotic Disorders, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: LiHua
authors: L
authors: Xu
authors: Shanghai Key Laboratory of Psychotic Disorders, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: TianHong
authors: T
authors: Zhang
authors: Department of Psychiatry, Liaocheng People's Hospital, Liaocheng, Shandong, China.
authors: LiNa
authors: L
authors: Zheng
authors: Department of Psychology, Florida Agricultural & Mechanical University, Tallahassee, Florida, United States of America.|Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
authors: HuiJun
authors: H
authors: Li
authors: Shanghai Key Laboratory of Psychotic Disorders, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: YingYing
authors: Y
authors: Tang
authors: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America.|VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut, United States of America.|Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.
authors: XingGuang
authors: X
authors: Luo
authors: Shanghai Key Laboratory of Psychotic Disorders, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: JianHua
authors: J
authors: Sheng
authors: Shanghai Key Laboratory of Psychotic Disorders, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: JiJun
authors: J
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China; D005260:Female; D000066505:Help-Seeking Behavior; D006801:Humans; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care / Q000523:psychology* / Q000706:statistics & numerical data; D062706:Prodromal Symptoms; D011594:Psychometrics; D011618:Psychotic Disorders / Q000175:diagnosis / Q000523:psychology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D055815:Young Adult