title: Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model.
abstract: Copeptin is the C-terminal end of pre-provasopressin released equimolar to vasopressin into circulation and recently discussed as promising cardiovascular biomarker amendatory to established markers such as troponins. Vasopressin is a cytokine synthesized in the hypothalamus. A direct release of copeptin from the heart into the circulation is implied by data from a rat model showing a cardiac origin in hearts put under cardiovascular wall stress. Therefore, evaluation of a potential release of copeptin from the human heart in acute myocardial infarction (AMI) has been done.
authors: Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7 60590 Frankfurt; Germany.|Institute for Cardiovascular Regeneration, Center of Molecular Medicine, Theodor Stern Kai 7, 60590 Frankfurt; Germany.|German Center of Cardiovascular Research (DZHK), RheinMain, 60590 Frankfurt, Germany.
authors: Jes-Niels
authors: JN
authors: Boeckel
authors: Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7 60590 Frankfurt; Germany.
authors: Jana
authors: J
authors: Oppermann
authors: Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7 60590 Frankfurt; Germany.
authors: Remzi
authors: R
authors: Anadol
authors: Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7 60590 Frankfurt; Germany.
authors: Stephan
authors: S
authors: Fichtlscherer
authors: Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7 60590 Frankfurt; Germany.|German Center of Cardiovascular Research (DZHK), RheinMain, 60590 Frankfurt, Germany.
authors: Andreas M
authors: AM
authors: Zeiher
authors: Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Theodor Stern Kai 7 60590 Frankfurt; Germany.|German Center of Cardiovascular Research (DZHK), RheinMain, 60590 Frankfurt, Germany.
authors: Till
authors: T
authors: Keller
mesh_terms: D000368:Aged; D001011:Aorta / Q000378:metabolism / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D006328:Cardiac Catheterization; D015331:Cohort Studies; D003326:Coronary Circulation; D005260:Female; D006020:Glycopeptides / Q000097:blood* / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology; D012907:Smoking / Q000097:blood / Q000503:physiopathology; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; D020107:Troponin T; C048197:copeptins