title: TAM receptor tyrosine kinase function and the immunopathology of liver disease.
abstract: Tyro3, Axl, MERTK (TAM) receptor tyrosine kinases are implicated in the regulation of the innate immune response through clearance of apoptotic cellular debris and control of cytokine signaling cascades. As a result they are pivotal in regulating the inflammatory response to tissue injury. Within the liver, immune regulatory signaling is employed to prevent the overactivation of innate immunity in response to continual antigenic challenge from the gastrointestinal tract. In this review we appraise current understanding of the role of TAM receptor function in the regulation of both innate and adaptive immunity, with a focus on its impact upon hepatic inflammatory pathology.
authors: Division of Digestive Diseases, Department of Medicine, Imperial College London, London, United Kingdom; and.
authors: S K
authors: SK
authors: Mukherjee
authors: Division of Digestive Diseases, Department of Medicine, Imperial College London, London, United Kingdom; and.
authors: A
authors: A
authors: Wilhelm
authors: Division of Digestive Diseases, Department of Medicine, Imperial College London, London, United Kingdom; and Division of Transplantation Immunology & Mucosal Biology, Institute of Liver Sciences, King's College London, London, United Kingdom c.antoniades@imperial.ac.uk.
authors: C G
authors: CG
authors: Antoniades
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008107:Liver Diseases / Q000276:immunology* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D000076202:c-Mer Tyrosine Kinase; D000094963:Axl Receptor Tyrosine Kinase
chemical_list: D016207:Cytokines; D011518:Proto-Oncogene Proteins; C097072:MERTK protein, human; D020794:Receptor Protein-Tyrosine Kinases; C084944:TYRO3 protein, human; D000076202:c-Mer Tyrosine Kinase; D000094963:Axl Receptor Tyrosine Kinase; C000722289:AXL protein, human
keywords: Axl; Mer; Tyro3, Axl, MERTK; antitumor immunity; immune regulation