title: An Enantioselective Assembly of Dihydropyranones through an NHC/LiCl-Mediated in situ Activation of α,β-Unsaturated Carboxylic Acids.
abstract: A straightforward N-heterocyclic carbene (NHC)/LiCl-mediated synthesis of dihydropyranones from α,β-unsaturated carboxylic acids and 1,3-dicarbonyl compounds was realized through the in situ activation strategy. The key advantages of this protocol include ready availability and high stability of starting materials, good yields, and excellent enantioselectivity.
authors: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional, Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, P. R. China.
authors: Yonglei
authors: Y
authors: Que
authors: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional, Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, P. R. China.
authors: Yinan
authors: Y
authors: Lu
authors: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional, Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, P. R. China.
authors: Wenjing
authors: W
authors: Wang
authors: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional, Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, P. R. China.
authors: Yuhong
authors: Y
authors: Wang
authors: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional, Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, P. R. China.
authors: Haotian
authors: H
authors: Wang
authors: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional, Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, P. R. China.
authors: Chenxia
authors: C
authors: Yu
authors: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional, Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, P. R. China.
authors: Tuanjie
authors: T
authors: Li
authors: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional, Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, P. R. China.
authors: Xiang-Shan
authors: XS
authors: Wang
authors: Xuzhou Institute of Architectural Technology, Xuzhou, Jiangsu, 221116, China.
authors: Shide
authors: S
authors: Shen
authors: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional, Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, P. R. China. csyao@jsnu.edu.cn.
authors: Changsheng
authors: C
authors: Yao
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D018021:Lithium Chloride / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D006571:Heterocyclic Compounds; D011753:Pyrones; C030011:carbene; D018021:Lithium Chloride; D008697:Methane
keywords: asymmetric synthesis; carbenes; carboxylic acids; dihydropyranones; enantioselectivity