title: Differential effect of mode of conception and infertility treatment on fetal growth and prematurity.
abstract: Objectives To examine perinatal outcomes in pregnancies conceived by different methods: fertile women with spontaneous pregnancies, infertile women who achieved pregnancy without treatment, pregnancies achieved by ovulation induction (OI) and in vitro fertilization or intra-cytoplasmic sperm injection (IVF/ICSI). Methods Retrospective single-center cohort study including 200 fertile and 748 infertile women stratified according to infertility treatment. The outcome measurements were preterm delivery (PTD), small-for-gestational-age (SGA), gestational diabetes, placenta previa or preeclampsia. Results The overall rate of pregnancy complications was significantly increased in all infertility groups regardless of the infertility treatment (adjusted odds ratio (OR): infertile without treatment 2.3 versus OI 2.2 versus IVF/ICSI 3.4). While PTD was mainly associated to IVF/ICSI (adjusted OR: infertile without treatment 1.3 versus OI 1.6 versus IVF/ICSI 3.3), SGA was significantly associated to both OI and IVF/ICSI (adjusted OR: infertile without treatment 1.9 versus OI 2.7 versus IVF/ICSI 2.6). All these associations remained statistically significant after adjusting by maternal age and twin pregnancy. Conclusions This study confirms the higher prevalence of pregnancy complications in infertile women irrespectively of receiving infertility treatment or not, and further describes a preferential association of prematurity with IVF/ICSI, and SGA with treated infertility (OI and IVF/ICSI).
authors: a BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan De Deu), Institut D'investigacions Biomèdiques August Pi I Sunyer, Universitat De Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER) , Barcelona , Spain and.
authors: Brenda
authors: B
authors: Valenzuela-Alcaraz
authors: a BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan De Deu), Institut D'investigacions Biomèdiques August Pi I Sunyer, Universitat De Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER) , Barcelona , Spain and.
authors: Fátima
authors: F
authors: Crispi
authors: b Infertility and Assited Reproduction Unit, Faculty of Medicine, University of Barcelona, Hospital Clínic Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) , Barcelona , Spain.
authors: Dolors
authors: D
authors: Manau
authors: a BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan De Deu), Institut D'investigacions Biomèdiques August Pi I Sunyer, Universitat De Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER) , Barcelona , Spain and.
authors: Mónica
authors: M
authors: Cruz-Lemini
authors: b Infertility and Assited Reproduction Unit, Faculty of Medicine, University of Barcelona, Hospital Clínic Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) , Barcelona , Spain.
authors: Aina
authors: A
authors: Borras
authors: b Infertility and Assited Reproduction Unit, Faculty of Medicine, University of Barcelona, Hospital Clínic Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) , Barcelona , Spain.
authors: Juan
authors: J
authors: Balasch
authors: a BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan De Deu), Institut D'investigacions Biomèdiques August Pi I Sunyer, Universitat De Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER) , Barcelona , Spain and.
authors: Eduard
authors: E
authors: Gratacós
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects* / Q000706:statistics & numerical data; D047109:Fetal Development; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D007247:Infertility, Female / Q000628:therapy*; D008297:Male; D010062:Ovulation Induction / Q000009:adverse effects* / Q000706:statistics & numerical data; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D047928:Premature Birth; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects
keywords: Assisted reproductive technologies; intrauterine growth restriction; low birth weight; perinatal outcome; small for gestational age