title: Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses.
abstract: Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little is known about the influence of H. pylori on the host's microbiota and immunity. Studying the interactions of H. pylori with murine hosts over 6 months, we found stable colonization accompanied by gastric histologic and antibody responses. Analysis of gastric and pulmonary tissues revealed increased expression of multiple immune response genes, conserved across mice and over time in the stomach and more transiently in the lungs. Moreover, H. pylori infection led to significantly different population structures in both the gastric and intestinal microbiota. These studies indicate that H. pylori influences the microbiota and host immune responses not only locally in the stomach, but distantly as well, affecting important target organs.
authors: Department of Medicine, NYU Langone Medical Center, New York, NY 10010, USA; Institute of Molecular Biosciences, University of Graz, Graz 8010, Austria; Institute of Pathology, Medical University of Graz, Graz 8043, Austria. Electronic address: sabine.kienesberger@uni-graz.at.
authors: Sabine
authors: S
authors: Kienesberger
authors: Department of Medicine, NYU Langone Medical Center, New York, NY 10010, USA; Department of Microbiology, NYU Langone Medical Center, New York, NY 10010, USA.
authors: Laura M
authors: LM
authors: Cox
authors: Department of Medicine, NYU Langone Medical Center, New York, NY 10010, USA.
authors: Alexandra
authors: A
authors: Livanos
authors: Department of Microbiology, NYU Langone Medical Center, New York, NY 10010, USA.
authors: Xue-Song
authors: XS
authors: Zhang
authors: Department of Medicine, NYU Langone Medical Center, New York, NY 10010, USA.
authors: Jennifer
authors: J
authors: Chung
authors: Department of Medicine, NYU Langone Medical Center, New York, NY 10010, USA; Department of Microbiology, NYU Langone Medical Center, New York, NY 10010, USA.
authors: Guillermo I
authors: GI
authors: Perez-Perez
authors: Institute of Pathology, Medical University of Graz, Graz 8043, Austria.
authors: Gregor
authors: G
authors: Gorkiewicz
authors: Institute of Molecular Biosciences, University of Graz, Graz 8010, Austria.
authors: Ellen L
authors: EL
authors: Zechner
authors: Department of Medicine, NYU Langone Medical Center, New York, NY 10010, USA; Department of Microbiology, NYU Langone Medical Center, New York, NY 10010, USA; VA Medical Center, New York, NY 10010, USA. Electronic address: martin.blaser@nyumc.org.
authors: Martin J
authors: MJ
authors: Blaser
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D004195:Disease Models, Animal; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology / Q000382:microbiology*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D016481:Helicobacter Infections / Q000235:genetics / Q000276:immunology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000254:growth & development / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D018836:Inflammation Mediators / Q000276:immunology; D008168:Lung / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D064307:Microbiota / Q000276:immunology*; D058977:Molecular Sequence Annotation; D015398:Signal Transduction; D013270:Stomach / Q000276:immunology / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D018836:Inflammation Mediators