title: High Trans Kinetic Selectivity in Ruthenium-Based Olefin Cross-Metathesis through Stereoretention.
abstract: The first kinetically controlled, highly trans-selective (>98%) olefin cross-metathesis reaction is demonstrated using Ru-based catalysts. Reactions with either trans or cis olefins afford products with highly trans or cis stereochemistry, respectively. This E-selective olefin cross-metathesis is shown to occur between two trans olefins and between a trans olefin and a terminal olefin. Additionally, new stereoretentive catalysts have been synthesized for improved reactivity.
authors: Materia, Inc., Pasadena, California 91107, United States.
authors: Adam M
authors: AM
authors: Johns
authors: The Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering. California Institute of Technology , Pasadena, California 91125, United States.
authors: Tonia S
authors: TS
authors: Ahmed
authors: Materia, Inc., Pasadena, California 91107, United States.
authors: Bradford W
authors: BW
authors: Jackson
authors: The Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering. California Institute of Technology , Pasadena, California 91125, United States.
authors: Robert H
authors: RH
authors: Grubbs
authors: Materia, Inc., Pasadena, California 91107, United States.
authors: Richard L
authors: RL
authors: Pederson