title: The 5-HT1A receptor in Major Depressive Disorder.
abstract: Major Depressive Disorder (MDD) is a highly prevalent psychiatric diagnosis that is associated with a high degree of morbidity and mortality. This debilitating disorder is currently one of the leading causes of disability nationwide and is predicted to be the leading cause of disease burden by the year 2030. A large body of previous research has theorized that serotonergic dysfunction, specifically of the serotonin (5-HT) 1A receptor, plays a key role in the development of MDD. The purpose of this review is to describe the evolution of our current understanding of the serotonin 1A (5-HT1A) receptor and its role in the pathophysiology MDD through the discussion of animal, post-mortem, positron emission tomography (PET), pharmacologic and genetic studies.
authors: Stony Brook University, Stony Brook, NY 11794, United States. Electronic address: Joshua.Kaufman@stonybrookmedicine.edu.
authors: Joshua
authors: J
authors: Kaufman
authors: Stony Brook University, Stony Brook, NY 11794, United States.
authors: Christine
authors: C
authors: DeLorenzo
authors: Stony Brook University, Stony Brook, NY 11794, United States.
authors: Sunia
authors: S
authors: Choudhury
authors: Stony Brook University, Stony Brook, NY 11794, United States.
authors: Ramin V
authors: RV
authors: Parsey
mesh_terms: D000818:Animals; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D049268:Positron-Emission Tomography; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics / Q000378:metabolism*
chemical_list: D044282:Receptor, Serotonin, 5-HT1A
keywords: 5-HT1A; Depression; Review