title: Desflurane reinforces the efficacy of propofol target-controlled infusion in patients undergoing laparoscopic cholecystectomy.
abstract: Whether low-concentration desflurane reinforces propofol-based intravenous anesthesia on maintenance of anesthesia for patients undergoing laparoscopic cholecystectomy is to be determined. The aim of this study was to investigate whether propofol-based anesthesia adding low-concentration desflurane is feasible for laparoscopic cholecystectomy. Fifty-two patients undergoing laparoscopic cholecystectomy were enrolled in the prospective, randomized, clinical trial. Induction of anesthesia was achieved in all patients with fentanyl 2 μg/kg, lidocaine 1 mg/kg, propofol 2 mg/kg, and rocuronium 0.8 mg/kg to facilitate tracheal intubation and to initiate propofol target-controlled infusion (TCI) to effect site concentration (Ce: 4 μg/mL with infusion rate 400 mL/h). The patients were then allocated into either propofol TCI based (group P) or propofol TCI adding low-concentration desflurane (group PD) for maintenance of anesthesia. The peri-anesthesia hemodynamic responses to stimuli were measured. The perioperative psychomotor test included p-deletion test, minus calculation, orientation, and alert/sedation scales. Group PD showed stable hemodynamic responses at CO2 inflation, initial 15 minutes of operation, and recovery from general anesthesia as compared with group P. There is no significant difference between the groups in operation time and anesthesia time, perioperative psychomotor functional tests, postoperative vomiting, and pain score. Based on our findings, the anesthetic technique combination propofol and desflurane for the maintenance of general anesthesia for laparoscopic cholecystectomy provided more stable hemodynamic responses than propofol alone. The combined regimen is recommended for patients undergoing laparoscopic cholecystectomy.
authors: Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors: Po-Nien
authors: PN
authors: Chen
authors: Faculty of Anesthesiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: I-Cheng
authors: IC
authors: Lu
authors: Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors: Hui-Ming
authors: HM
authors: Chen
authors: Faculty of Anesthesiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Kuang-I
authors: KI
authors: Cheng
authors: Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors: Kuang-Yi
authors: KY
authors: Tseng
authors: Faculty of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: ponien.chen@msa.hinet.net.
authors: King-Teh
authors: KT
authors: Lee
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D017081:Cholecystectomy, Laparoscopic / Q000379:methods; D000077335:Desflurane; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007530:Isoflurane / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D000077335:Desflurane; D007530:Isoflurane; D015742:Propofol
keywords: Desflurane; Laparoscopic cholecystectomy; Propofol; Target-controlled infusion