title: Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4.
abstract: Escherichia coli O104:H4-associated hemolytic uremic syndrome (HUS) is characterized by Shiga toxin-induced vascular damage. As indicated by recent studies, dysregulation of the angiopoietin (Angpt)/Tie2 ligand receptor system may be crucial for endothelial dysfunction in HUS. Early Angpt-2 levels quantified in 48 adult HUS patients were predictive for a complicated clinical course, in particular for need of hemodialysis and mechanical ventilation as well as occurrence of seizures. In vitro challenge of human umbilical vein endothelial cells with patients' sera indicated an injurious mediator role of Angpt-2 opening future perspectives for mitigating endothelial activation in HUS.
authors: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany; Department of Medicine, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany.
authors: Alexander
authors: A
authors: Lukasz
authors: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.
authors: Jan
authors: J
authors: Beneke
authors: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.
authors: Kristina
authors: K
authors: Thamm
authors: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.
authors: Jan T
authors: JT
authors: Kielstein
authors: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.
authors: Jan
authors: J
authors: Menne
authors: Department of Hematology, Hemostaseology, Oncology and Pneumonology, University Hospital Münster, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany.
authors: Jan-Henrik
authors: JH
authors: Mikesch
authors: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.
authors: Bernhard M W
authors: BM
authors: Schmidt
authors: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.
authors: Hermann
authors: H
authors: Haller
authors: Department of Medicine, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany.
authors: Philipp
authors: P
authors: Kümpers
authors: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.
authors: Sascha
authors: S
authors: David
authors: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.
authors: Mario
authors: M
authors: Schiffer
mesh_terms: D000328:Adult; D042702:Angiopoietin-2 / Q000032:analysis / Q000378:metabolism*; D015331:Cohort Studies; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D042787:Receptor, TIE-2 / Q000378:metabolism*; D054323:Shiga-Toxigenic Escherichia coli
chemical_list: C586513:ANGPT2 protein, human; D042702:Angiopoietin-2; D042787:Receptor, TIE-2