title: Technology, Applications, and Process Challenges of Dual Chamber Systems.
abstract: Dual-chamber systems provide an option as a drug and device combination product, when home care and emergency lyophilized products are intended. Nevertheless, until today, there are only a few products on the market, due to the challenges and limitations in manufacturability, product formulation, and product stability in a dual-chamber configuration, as well as economic considerations. This review serves to describe currently available dual-chamber systems and to discuss factors to be considered for appropriate selection and establishing fill-finish processes.
authors: Department of Pharmaceutical Technology, University of Basel, Basel, Switzerland; Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland. Electronic address: tobias.werk@roche.com.
authors: Tobias
authors: T
authors: Werk
authors: Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
authors: Imke S
authors: IS
authors: Ludwig
authors: Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
authors: Joerg
authors: J
authors: Luemkemann
authors: Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
authors: Hanns-Christian
authors: HC
authors: Mahler
authors: Department of Pharmaceutical Technology, University of Basel, Basel, Switzerland.
authors: Joerg
authors: J
authors: Huwyler
authors: Institute for Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Mannheim, Germany.
authors: Mathias
authors: M
authors: Hafner
mesh_terms: D004867:Equipment Design; D005612:Freeze Drying / Q000295:instrumentation* / Q000379:methods*; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry; D013594:Syringes; D013678:Technology, Pharmaceutical / Q000295:instrumentation* / Q000379:methods*
chemical_list: D011506:Proteins
keywords: aseptic processing; biologics; biopharmaceutical; dual-chamber cartridge; dual-chamber syringe; dual-chamber systems; fixed dose combination; freeze-drying; home care; small volume parenterals