title: Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents.
abstract: BACKGROUND
  Carica papaya is a well known medicinal plant used in the West and Asian countries to cope several diseases. Patients were advised to eat papaya fruit frequently during dengue fever epidemic in Pakistan by physicians. This study was conducted to establish Polyphenols, flavonoids and antioxidant potential profile of extracts of all major parts of the C. papaya with seven major solvents i.e. water, ethanol, methanol, n-butanol, dichloromethane, ethyl acetate, and n-hexane.
  
  
  RESULTS
  TPC, TFC, antioxidant and antibacterial potential were determined using different aqueous and organic solvents in addition to the determination of trace element in leaves, pulp and peel of C. papaya. Total soluble phenolics and flavonoids were found in promising quantity (≈66 mg GAE/g) especially in case of methanol and ethanol extracts. Antioxidant activity using DPPH free radical scavenging assay indicated leaves, bark, roots and pulp extracts showed >75.0 % scavenging potential while leaves and pulp showed 84.9 and 80.9 % inhibition of peroxidation, respectively. Reducing power assay showed leaves, pulp and roots extracts active to reduce Fe(3+) to Fe(2+) ions. The antibacterial study showed pulp extract is the best to cope infectious action of bacteria.
  
  
  CONCLUSIONS
  This study was conducted to test the medicinal profile of all parts of C. papaya by extracting secondary metabolites with organic and aqueous solvents. Ethanol and methanol both were found to be the best solvents of choice to extract natural products to get maximum medicinal benefits and could be used to medicinal formulation against different infectious diseases.Graphical abstractMedicinal evaluation of different parts of C. papaya.
authors: Department of Chemistry, Government College University, Faisalabad, 38000 Pakistan.
authors: Nazia
authors: N
authors: Asghar
authors: Department of Chemistry, Government College University, Faisalabad, 38000 Pakistan.
authors: Syed Ali Raza
authors: SA
authors: Naqvi
authors: Institute of Chemistry, University of the Punjab, Lahore, 54000 Pakistan.
authors: Zaib
authors: Z
authors: Hussain
authors: Department of Chemistry, Government College University, Faisalabad, 38000 Pakistan.
authors: Nasir
authors: N
authors: Rasool
authors: Department of Chemistry, Government College University, Faisalabad, 38000 Pakistan.
authors: Zulfiqar Ali
authors: ZA
authors: Khan
authors: Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060 Pakistan.
authors: Sohail Anjum
authors: SA
authors: Shahzad
authors: Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060 Pakistan.
authors: Tauqir A
authors: TA
authors: Sherazi
authors: Department of Chemistry, University of Sargodha, Sargodha, 40100 Pakistan.
authors: Muhammad Ramzan Saeed Ashraf
authors: MR
authors: Janjua
authors: Institute of Chemistry, University of the Punjab, Lahore, 54000 Pakistan.
authors: Saeed Ahmad
authors: SA
authors: Nagra
authors: The Patent Office, Karachi, Pakistan.
authors: Muhammad
authors: M
authors: Zia-Ul-Haq
authors: Department of Crop Science, Faculty of Agriculture, UPM, 43400 Serdang, Selangor Malaysia.
authors: Hawa Ze
authors: HZ
authors: Jaafar