title: Neonatal Risk Factors for Treatment-Demanding Retinopathy of Prematurity: A Danish National Study.
abstract: OBJECTIVE
  One goal of the study was to identify "new" statistically independent risk factors for treatment-demanding retinopathy of prematurity (ROP). Another goal was to evaluate whether any new risk factors could explain the increase in the incidence of treatment-demanding ROP over time in Denmark.
  
  
  METHODS
  A retrospective, register-based cohort study.
  
  
  METHODS
  The study included premature infants (n = 6490) born in Denmark from 1997 to 2008.
  
  
  METHODS
  The study sample and the 31 candidate risk factors were identified in 3 national registers. Data were linked through a unique civil registration number. Each of the 31 candidate risk factors were evaluated in univariate analyses, while adjusted for known risk factors (i.e., gestational age [GA] at delivery, small for gestational age [SGA], multiple births, and male sex). Significant outcomes were analyzed thereafter in a backward selection multiple logistic regression model.
  
  
  METHODS
  Treatment-demanding ROP and its associations to candidate risk factors.
  
  
  RESULTS
  Mechanical ventilation (odds ratio [OR], 2.84; 95% confidence interval [CI], 1.99-4.08; P < 0.01) and blood transfusion (OR, 1.97; 95% CI, 1.20-3.14; P = 0.01) were the only new statistically independent risk factors, in addition to GA at delivery, SGA, multiple births, and male sex. Modification in these prognostic factors for ROP did not cause an increase in treatment-demanding ROP.
  
  
  CONCLUSIONS
  In a large study population, blood transfusion and mechanical ventilation were the only new statistically independent risk factors to predict the development of treatment-demanding ROP. Modification in the neonatal treatment with mechanical ventilation or blood transfusion did not cause the observed increase in the incidence of preterm infants with treatment-demanding ROP during a recent birth period (2003-2008).
authors: Department of Ophthalmology, Copenhagen University Hospital, Glostrup Hospital and Rigshospitalet, Denmark. Electronic address: carinaslidsborg@hotmail.com.
authors: Carina
authors: C
authors: Slidsborg
authors: Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark; Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
authors: Aksel
authors: A
authors: Jensen
authors: Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
authors: Julie Lyng
authors: JL
authors: Forman
authors: Department of Clinical Microbiology, Hvidovre Hospital, Hvidovre, Denmark.
authors: Steen
authors: S
authors: Rasmussen
authors: Department of Ophthalmology, Copenhagen University Hospital, Glostrup Hospital and Rigshospitalet, Denmark.
authors: Regitze
authors: R
authors: Bangsgaard
authors: Department of Ophthalmology, Copenhagen University Hospital, Glostrup Hospital and Rigshospitalet, Denmark.
authors: Hans Callø
authors: HC
authors: Fledelius
authors: Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark.
authors: Gorm
authors: G
authors: Greisen
authors: Department of Ophthalmology, Copenhagen University Hospital, Glostrup Hospital and Rigshospitalet, Denmark.
authors: Morten
authors: M
authors: la Cour
mesh_terms: D001803:Blood Transfusion / Q000706:statistics & numerical data*; D015331:Cohort Studies; D017679:Cryotherapy; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D017075:Laser Coagulation / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D012042:Registries; D012121:Respiration, Artificial; D012178:Retinopathy of Prematurity / Q000453:epidemiology* / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors; D012591:Scleral Buckling; D012680:Sensitivity and Specificity; D014821:Vitrectomy