title: Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data.
abstract: Personalised medicine tumour boards, which leverage genomic data to improve clinical management, are becoming standard for the treatment of many cancers. This paper is designed as a primer to assist clinicians treating head and neck squamous cell carcinoma (HNSCC) patients with an understanding of the discovery and functional impact of recurrent genetic lesions that are likely to influence the management of this disease in the near future. This manuscript integrates genetic data from publicly available array comparative genome hybridization (aCGH) and next-generation sequencing genetics databases to identify the most common molecular alterations in HNSCC. The importance of these genetic discoveries is reviewed and how they may be incorporated into clinical care decisions is discussed. Considerations for the role of genetic stratification in the clinical management of head and neck cancer are maturing rapidly and can be improved by integrating data sets. This article is meant to summarise the discoveries made using multiple genomic platforms so that the head and neck cancer care provider can apply these discoveries to improve clinical care.
authors: Institute of Human Genetics, Polish Academy of Sciences, Department of Cancer Genetics, 60-479, Poznan, Poland; Department of Otolaryngology and Laryngological Oncology, K. Marcinkowski University of Medical Sciences, 60-355, Poznan, Poland.
authors: M
authors: M
authors: Giefing
authors: Department of Otolaryngology and Laryngological Oncology, K. Marcinkowski University of Medical Sciences, 60-355, Poznan, Poland.
authors: M
authors: M
authors: Wierzbicka
authors: Institute of Human Genetics, Polish Academy of Sciences, Department of Cancer Genetics, 60-479, Poznan, Poland; Department of Phoniatrics and Audiology, K. Marcinkowski University of Medical Sciences, 60-355, Poznan, Poland.
authors: K
authors: K
authors: Szyfter
authors: Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: chadbren@umich.edu.
authors: J C
authors: JC
authors: Brenner
authors: Department of Otolaryngology - Head and Neck Surgery, VU University Medical Center, Amsterdam, the Netherlands.
authors: B J
authors: BJ
authors: Braakhuis
authors: Department of Otolaryngology - Head and Neck Surgery, VU University Medical Center, Amsterdam, the Netherlands.
authors: R H
authors: RH
authors: Brakenhoff
authors: Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.
authors: C R
authors: CR
authors: Bradford
authors: Department of Plastic Surgery, Odense University Hospital, Denmark.
authors: J A
authors: JA
authors: Sorensen
authors: University of Udine School of Medicine, Udine, Italy.
authors: A
authors: A
authors: Rinaldo
authors: Departament of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain; Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain.
authors: J P
authors: JP
authors: Rodrigo
authors: Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: R P
authors: RP
authors: Takes
authors: Coordinator of the International Head and Neck Scientific Group, Italy.
authors: A
authors: A
authors: Ferlito
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D055028:Comparative Genomic Hybridization; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D018579:Patient Selection; D010641:Phenotype; D057285:Precision Medicine; D011237:Predictive Value of Tests; D000077195:Squamous Cell Carcinoma of Head and Neck; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
keywords: Genetic complexity; HNSCC; NGS technology; Personalised medicine; Target genes; Tumour heterogeneity