title: The D9N, N291S, and T495G Polymorphisms of the Lipoprotein Lipase Gene Are Not Associated with Cerebral Infarction.
abstract: BACKGROUND
  Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism and its polymorphisms are possibly implicated in the etiology of ischemic cerebrovascular disease (CVD). The aim of this work was to determine the association of the of D9N, N291S, and T495G polymorphisms of the LPL gene as a risk factor for the development of CVD.
  
  
  METHODS
  A case-control study was conducted that included 100 patients with CVD and 120 healthy controls. All the subjects were genotyped for the D9N, N291S, and T495G polymorphisms of the LPL gene through polymerase chain reaction-restriction fragment length polymorphism, and the results were analyzed for their association with CVD.
  
  
  RESULTS
  The D9N genotype was not significantly correlated with CVD; the odds ratio (OR) between the control subjects and CVD patients was .29 (95% confidence interval [CI], .03-2.66; P = .27). The N291S polymorphism was not significantly correlated with CVD either; the OR between the control subjects and CVD patients was 1.2 (95% CI, .07-19.46; P = .89). And the T495G mutation was not significantly correlated with CVD; the OR between the control subjects and the CVD patients was 1.21 (95% CI, .7-2.08; P = .48).
  
  
  CONCLUSIONS
  In the present study, the D9N, N291S, and T495G polymorphisms of the LPL gene were not risk factors for the development of CVD.
authors: School of Medicine, Universidad de Colima, Colima, Mexico.
authors: Gabriel
authors: G
authors: Ceja-Espíritu
authors: School of Medicine, Universidad de Colima, Colima, Mexico.
authors: Ivan
authors: I
authors: Delgado-Enciso
authors: University Center for Biomedical Research, Universidad de Colima, Colima, Mexico.
authors: Mario
authors: M
authors: Ramírez-Flores
authors: Clinical Epidemiologic Research Unit, Hospital General de Zona UMF No.1 IMSS, Colima, Mexico. Electronic address: pepeguzman_esquivel@outlook.com.
authors: José
authors: J
authors: Guzmán-Esquivel
authors: School of Medicine, Universidad de Colima, Colima, Mexico.
authors: Luz M
authors: LM
authors: Baltazar-Rodríguez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D008071:Lipoprotein Lipase
keywords: Protein lipase; association; ischemic cerebrovascular; polymorphisms; risk