title: Intracoronary injection of tirofiban prevents microcirculation dysfunction during delayed percutaneous coronary intervention in patients with acute myocardial infarction.
abstract: OBJECTIVE
  To determine whether tirofiban can prevent microcirculation dysfunction during delayed percutaneous coronary intervention (PCI) of spontaneously recanalized and severe narrowing coronary artery in patients with acute myocardial infarction.
  
  
  METHODS
  62 patients who have a single angiographically confirmed narrowing culprit coronary artery for more than 75% between 7 and 14 days after the onset of acute myocardial infarction were randomly divided into the tirofiban group (32 cases) and the placebo group (30 cases). All the patients received measurement of the index of microcirculatory resistance (IMR) before tirofiban/placebo administration and PCI. After PCI, IMR value was measured again.
  
  
  RESULTS
  There was no significant variation between the two groups before PCI (11.67 ± 6.45 of placebo group vs. 14.65 ± 12.45 of tirofiban group, P=0.158). After PCI, the IMR value of the tirofiban group is significantly lower than that of the placebo group (23.63 ± 9.91 of placebo group vs. 16.75 ± 9.98 of tirofiban group, P=0.008).
  
  
  CONCLUSIONS
  Intracoronary injection of tirofiban can significantly prevent the abnormal increase of IMR value during delayed PCI in patients with acute myocardial infarction.
authors: Cardiovascular Disease Research Unit, Department of Cardiology, Xiangtan City Central Hospital, attached Central South University, China.
authors: Zhishan
authors: Z
authors: Sun
authors: Cardiovascular Disease Research Unit, Department of Cardiology, Xiangtan City Central Hospital, attached Central South University, China. Electronic address: clinton_sun@163.com.
authors: Jianping
authors: J
authors: Zeng
authors: Cardiovascular Disease Research Unit, Department of Cardiology, Xiangtan City Central Hospital, attached Central South University, China.
authors: He
authors: H
authors: Huang
mesh_terms: D000368:Aged; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008833:Microcirculation / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000639:trends*; D011446:Prospective Studies; D000077466:Tirofiban; D014443:Tyrosine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D005343:Fibrinolytic Agents; D014443:Tyrosine; D000077466:Tirofiban
keywords: Delayed percutaneous coronary intervention; Index of microcirculatory resistance; Tirofiban