title: Intravoxel incoherent motion MR imaging for breast lesions: comparison and correlation with pharmacokinetic evaluation from dynamic contrast-enhanced MR imaging.
abstract: OBJECTIVE
  To compare diagnostic performance for breast lesions by quantitative parameters derived from intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and to explore whether correlations exist between these parameters.
  
  
  METHODS
  IVIM and DCE MRI were performed on a 1.5-T MRI scanner in patients with suspicious breast lesions. Thirty-six breast cancers and 23 benign lesions were included in the study. Quantitative parameters from IVIM (D, f and D*) and DCE MRI (Ktrans, Kep, Veand Vp) were calculated and compared between malignant and benign lesions. Spearman correlation test was used to evaluate correlations between them.
  
  
  RESULTS
  D, f, D* from IVIM and Ktrans, Kep, Vpfrom DCE MRI were statistically different between breast cancers and benign lesions (p < 0.05, respectively) and D demonstrated the largest area under the receiver-operating characteristic curve (AUC = 0.917) and had the highest specificity (83 %). The f value was moderately statistically correlated with Vp(r = 0.692) and had a poor correlation with Ktrans(r = 0.456).
  
  
  CONCLUSIONS
  IVIM MRI is useful in the differentiation of breast lesions. Significant correlations were found between perfusion-related parameters from IVIM and DCE MRI. IVIM may be a useful adjunctive tool to standard MRI in diagnosing breast cancer.
  
  
  CONCLUSIONS
  • IVIM provided diffusion as well as perfusion information • IVIM could help differential diagnosis of breast lesions • Correlations were found between perfusion-related parameters from IVIM and DCE MRI.
authors: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, GuangZhou, China, 510080.
authors: Chunling
authors: C
authors: Liu
authors: Department of Breast Cancer, Cancer Center, Guangdong General Hospital/Guangdong Academy of Medical Sciences, GuangZhou, China, 510080.
authors: Kun
authors: K
authors: Wang
authors: Philips Healthcare, 6/F, Core Building 1, 1 Science Park East Avenue, Hong Kong Science Park, Shatin, New Territories, Hong Kong, China.
authors: Queenie
authors: Q
authors: Chan
authors: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, GuangZhou, China, 510080.
authors: Zaiyi
authors: Z
authors: Liu
authors: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, GuangZhou, China, 510080.
authors: Jine
authors: J
authors: Zhang
authors: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, GuangZhou, China, 510080.
authors: Hui
authors: H
authors: He
authors: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, GuangZhou, China, 510080.
authors: Shuixing
authors: S
authors: Zhang
authors: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, GuangZhou, China, 510080. cjr.lchh@vip.163.com.
authors: Changhong
authors: C
authors: Liang
mesh_terms: D000328:Adult; D000368:Aged; D000071960:Breast Carcinoma In Situ / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D003287:Contrast Media / Q000493:pharmacokinetics; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D006801:Humans; D008875:Middle Aged; D009038:Motion; D015588:Observer Variation; D010477:Perfusion; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA
keywords: Breast neoplasm; DCE MRI; Diffusion-weighted imaging; Intravoxel incoherent motion; Magnetic resonance imaging