title: Lifestyle modification and weight reduction among low-income patients with the metabolic syndrome: the CHARMS randomized controlled trial.
abstract: Although weight is an important intervention target among patients with metabolic syndrome, few trials have recruited low-income minority populations. The Community Health and Risk-reduction for Metabolic Syndrome randomized controlled trial aimed to examine the effects of a lifestyle intervention on weight and metabolic syndrome components among low-income minority adults. We randomized 120 adults with metabolic syndrome to standard medical care (N = 60) or a lifestyle intervention (N = 60). Using an intent-to-treat approach, we found significant intervention effects on weight [B = -0.452; SE = 0.122; 95 % confidence intervals (CI) -0.653 to -0.251) and glucose levels at 6-months (B = -0.522, SE = 0.234, 95 % CI -0.907 to -0.138). These changes were maintained through the 12-month assessment. No significant effects were observed on insulin resistance or other metabolic syndrome components. Our intervention was successful in achieving modest but significant weight loss and reduction in fasting glucose among low-income minority subjects with metabolic syndrome.
authors: Department of Psychology, University of Miami, P.O. Box 248185, Coral Gables, FL, 33124-0751, USA. d.chirinosmedina@umiami.edu.
authors: Diana A
authors: DA
authors: Chirinos
authors: Diabetes Research Institute, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, FL, USA.|Division of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors: Ronald B
authors: RB
authors: Goldberg
authors: Department of Psychology, University of Miami, P.O. Box 248185, Coral Gables, FL, 33124-0751, USA.
authors: Maria M
authors: MM
authors: Llabre
authors: Department of Psychology, University of Miami, P.O. Box 248185, Coral Gables, FL, 33124-0751, USA.
authors: Marc
authors: M
authors: Gellman
authors: Division of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors: Miriam
authors: M
authors: Gutt
authors: Department of Psychology, University of Miami, P.O. Box 248185, Coral Gables, FL, 33124-0751, USA.
authors: Judith
authors: J
authors: McCalla
authors: Diabetes Research Institute, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors: Armando
authors: A
authors: Mendez
authors: Department of Psychology, University of Miami, P.O. Box 248185, Coral Gables, FL, 33124-0751, USA.
authors: Neil
authors: N
authors: Schneiderman
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000628:therapy*; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011203:Poverty; D040242:Risk Reduction Behavior; D015431:Weight Loss
keywords: Cardiovascular disease; Hispanics; Intervention; Metabolic syndrome; Minority populations; Randomized controlled trial; Weight