title: Prediction of orthostatic hypotension in multiple system atrophy and Parkinson disease.
abstract: Orthostatic hypotension (OH) is common in multiple system atrophy (MSA) and Parkinson disease (PD), generally assessed through a lying-to-standing orthostatic test. However, standing blood pressure may not be available due to orthostatic intolerance or immobilization for such patients. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were successively measured in supine, sitting, and standing positions in patients with MSA and PD. Receiver operating characteristic analysis was used to evaluate diagnostic performance of the drops of sitting SBP or DBP. OH and severe OH were respectively regarded as "gold standard". The drops of SBP in standing position were associated with increased disease severity for MSA and correlated with age for PD. In MSA group, drops in sitting SBP ≥ 14 mmHg or DBP ≥ 6 mmHg had highest validity for prediction of OH, and drops in sitting SBP ≥ 18 mmHg or DBP ≥ 8 mmHg for severe OH. In PD group, drops in sitting SBP ≥ 10 mmHg or DBP ≥ 6 mmHg had highest validity for prediction of OH. The lying-to-sitting orthostatic test is an alternative method for detection of OH in MSA and PD, especially when standing BP could not be validly measured due to various reasons.
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Zhanfang
authors: Z
authors: Sun
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Dandan
authors: D
authors: Jia
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Yuting
authors: Y
authors: Shi
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Xuan
authors: X
authors: Hou
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Xiaosu
authors: X
authors: Yang
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Jifeng
authors: J
authors: Guo
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Nan
authors: N
authors: Li
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Junling
authors: J
authors: Wang
authors: Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Qiying
authors: Q
authors: Sun
authors: Department of Neurology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Hainan
authors: H
authors: Zhang
authors: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Lifang
authors: L
authors: Lei
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.|Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan 410008, P. R. China.|State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Lu
authors: L
authors: Shen
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.|Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Xinxiang
authors: X
authors: Yan
authors: State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Kun
authors: K
authors: Xia
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.|Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan 410008, P. R. China.|State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Hong
authors: H
authors: Jiang
authors: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.|Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan 410008, P. R. China.|State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410008, P. R. China.
authors: Beisha
authors: B
authors: Tang
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003661:Decision Support Techniques; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D019578:Multiple System Atrophy / Q000150:complications*; D010300:Parkinson Disease / Q000150:complications*; D012372:ROC Curve