title: High expression of CD38, CD69, CD95 and CD154 biomarkers in cultured peripheral T lymphocytes correlates with an increased risk of acute rejection in liver allograft recipients.
abstract: The mayor goal still outstanding into the solid organ transplantation field involves the search of surrogate biomarkers able to predict several clinical events, such as acute rejection (AR) or opportunistic infection. In the present multicenter study, a series of interesting surface antigens with important activator or inhibitory immune functions on cultured peripheral T cells were monitored in liver transplant recipients drawn at baseline and up to one year after transplantation. Sixty-four patients were included in the multicenter study during 3 years. Pre- and post-transplantation surface antigens levels displayed significant differences between AR and non acute rejection (NAR) groups, and also this differential expression was used to construct a risk predictive model based on a composite panel of outcome biomarkers (CD38, CD69, CD95 and CD154). The model was able to stratify these patients at high risk of AR. These preliminary results could provide basic information to improve the immunosuppressive treatment and it might better help to predict AR episodes.
authors: Immunology Service, Clinical University Hospital ́Virgen de la Arrixacá-IMIB (Murcian Institute of Biomedical Investigation), Murcia, Spain.
authors: Francisco
authors: F
authors: Boix
authors: Pharmacology and Toxicology, Biomedical Diagnostic Center, IDIBAPS, Clinic Hospital, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.
authors: Olga
authors: O
authors: Millan
authors: Immunology Service, University Hospital ́Marques Valdecillá-IDIVAL, Santander, Spain.
authors: David
authors: D
authors: San Segundo
authors: Investigation Institute ́12 de Octubré, Immunology Service, Hospital ́12 de Octubré, Medicine Faculty, Complutense University, Madrid, Spain.
authors: Esther
authors: E
authors: Mancebo
authors: Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Liver Unit, Biomedical Diagnostic Center, IDIBAPS, Clinic Hospital, Barcelona, Spain.
authors: Antoni
authors: A
authors: Rimola
authors: Digestive Medicine, University Hospital ́Marques de Valdecillá-IDIVAL, Santander, Spain.
authors: Emilio
authors: E
authors: Fabrega
authors: Pharmacology and Toxicology, Biomedical Diagnostic Center, IDIBAPS, Clinic Hospital, Barcelona, Spain.
authors: Virginia
authors: V
authors: Fortuna
authors: Immunology Service, Clinical University Hospital ́Virgen de la Arrixacá-IMIB (Murcian Institute of Biomedical Investigation), Murcia, Spain.
authors: Anna
authors: A
authors: Mrowiec
authors: Investigation Institute ́12 de Octubré, Immunology Service, Hospital ́12 de Octubré, Medicine Faculty, Complutense University, Madrid, Spain.
authors: Maria J
authors: MJ
authors: Castro-Panete
authors: Pathology Service, Clinical University Hospital ́Virgen de la Arrixacá, Murcia, Spain.
authors: Jesus de la
authors: Jde L
authors: Peña
authors: Nephrology Service, Clinical University Hospital ́Virgen de la Arrixacá, Murcia, Spain.
authors: Santiago
authors: S
authors: Llorente
authors: Immunology Service, Clinical University Hospital ́Virgen de la Arrixacá-IMIB (Murcian Institute of Biomedical Investigation), Murcia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.
authors: Alfredo
authors: A
authors: Minguela
authors: Immunology Service, Clinical University Hospital ́Virgen de la Arrixacá-IMIB (Murcian Institute of Biomedical Investigation), Murcia, Spain.
authors: Jose M
authors: JM
authors: Bolarin
authors: Investigation Institute ́12 de Octubré, Immunology Service, Hospital ́12 de Octubré, Medicine Faculty, Complutense University, Madrid, Spain.
authors: Estela
authors: E
authors: Paz-Artal
authors: Immunology Service, University Hospital ́Marques Valdecillá-IDIVAL, Santander, Spain.
authors: Marcos
authors: M
authors: Lopez-Hoyos
authors: Pharmacology and Toxicology, Biomedical Diagnostic Center, IDIBAPS, Clinic Hospital, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.
authors: Mercé
authors: M
authors: Brunet
authors: Immunology Service, Clinical University Hospital ́Virgen de la Arrixacá-IMIB (Murcian Institute of Biomedical Investigation), Murcia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain. Electronic address: manuel.muro@carm.es.
authors: Manuel
authors: M
authors: Muro
mesh_terms: D051997:ADP-ribosyl Cyclase 1; D000328:Adult; D000368:Aged; D064591:Allografts / Q000276:immunology* / Q000378:metabolism; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D023201:CD40 Ligand; D002478:Cells, Cultured; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D037181:Lectins, C-Type; D016031:Liver Transplantation / Q000009:adverse effects; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011379:Prognosis; D012372:ROC Curve; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D055815:Young Adult; D019014:fas Receptor; D000099192:CD69 Antigens
chemical_list: D051997:ADP-ribosyl Cyclase 1; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D023201:CD40 Ligand; D007166:Immunosuppressive Agents; D037181:Lectins, C-Type; D019014:fas Receptor; D000099192:CD69 Antigens
keywords: Acute rejection; Biomarkers; Immunosuppressive treatment; Liver transplantation; Surface antigens