title: Epigenetics and addiction.
abstract: Addictions are public health menaces. However, despite advances in addiction research, the cellular or molecular mechanisms that cause transition from recreational use to addiction remain to be elucidated. We have recently suggested that addiction may be secondary to long-term epigenetic modifications that determine the clinical course of substance use disorders. A better understanding of epigenetic mechanisms in animal models that mimic human conditions should help to usher in a new area of drug development against addiction.
authors: Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.
authors: J L
authors: JL
authors: Cadet
authors: Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.
authors: M T
authors: MT
authors: McCoy
authors: Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.
authors: S
authors: S
authors: Jayanthi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015195:Drug Design; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D011634:Public Health; D019966:Substance-Related Disorders / Q000188:drug therapy / Q000235:genetics*