title: Serum concentrations of 25-hydroxyvitamin D and its association with bone mineral density and serum parathyroid hormone levels during winter in urban males from Guiyang, Southwest China.
abstract: Serum vitamin D (25-hydroxyvitamin D (25OHD)) may influence serum parathyroid hormone (PTH) levels and bone mineral density (BMD). In the present study, we assessed serum 25OHD concentration and its association with PTH and BMD in urban males from Guiyang (N26.57°), the capital city of Guizhou province, Southwest China. We recruited 634 males aged >20 years from the Guiyang Health Measures Survey, and stratified them into three groups according to age: young (20-39 years), middle aged (40-59 years) and older (60-79 years). We measured serum concentrations of 25OHD, PTH levels and BMD of the lumbar spine (L1-L4), femoral neck and total hip. In addition, we also explored the relationship between 25OHD and lifestyle, socio-economic characteristics and medical history by applying covariance analysis and locally weighted regression plots. The results showed that serum 25OHD was 75 nmol/l in 12·6 % of the subjects. Higher level of serum PTH was detected in relation to lower concentrations of serum 25OHD up to 50 nmol/l. A negative correlation between serum 25OHD and PTH concentrations was observed (r -0·207, P=0·003). Mean concentration of serum PTH increased gradually and plateaued while concentrations of serum 25OHD decreased to 50 nmol/l. Gradual increase in serum PTH was observed as 25OHD concentration was <25 nmol/l (P=0·004). BMD values at all sites were greater in the higher serum 25OHD concentration group. This study shows that low concentrations of serum 25OHD were common in males, and bone health was likely to be improved when serum 25OHD values were between 30 and 50 nmol/l.
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Qiao
authors: Q
authors: Zhang
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Lixin
authors: L
authors: Shi
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Nianchun
authors: N
authors: Peng
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Shujing
authors: S
authors: Xu
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Miao
authors: M
authors: Zhang
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Song
authors: S
authors: Zhang
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Hong
authors: H
authors: Li
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Huijun
authors: H
authors: Zhuang
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Mingxian
authors: M
authors: Gong
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Danrong
authors: D
authors: Wu
authors: Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.
authors: Rui
authors: R
authors: Wang
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood; D000328:Adult; D000368:Aged; D000375:Aging; D015519:Bone Density; D002112:Calcifediol / Q000097:blood*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D010018:Osteomalacia / Q000453:epidemiology / Q000209:etiology*; D010281:Parathyroid Hormone / Q000097:blood*; D012306:Risk; D012621:Seasons; D014504:Urban Health; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D055815:Young Adult
chemical_list: C470125:PTH protein, human; D010281:Parathyroid Hormone; D015652:25-Hydroxyvitamin D 2; D002112:Calcifediol
keywords: 25OHD 25-hydroxyvitamin D; Bone mineral density; Cr creatinine; PTH parathyroid hormone; Parathyroid hormone; Serum 25-hydroxyvitamin D; Southwest China