title: Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction.
abstract: A novel photogelling mechanism by the phototriggered-imine-crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o-nitrobenzene, a photogenerated aldehyde group, can quickly photo-crosslink with amino-bearing polymers or proteins. Once the in situ photogelling on a wound occurs, the PIC gelling process can well integrate a hydrogel with surrounding tissue by covalent bonding, thus making it a powerful tool for tissue engineering and regenerative medicine.
authors: Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China.
authors: Yunlong
authors: Y
authors: Yang
authors: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, 600# Yishan Road, Shanghai, 200233, China.
authors: Jieyuan
authors: J
authors: Zhang
authors: Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China.
authors: Zhenzhen
authors: Z
authors: Liu
authors: Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China.
authors: Qiuning
authors: Q
authors: Lin
authors: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, 600# Yishan Road, Shanghai, 200233, China.
authors: Xiaolin
authors: X
authors: Liu
authors: Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China.
authors: Chunyan
authors: C
authors: Bao
authors: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, 600# Yishan Road, Shanghai, 200233, China.
authors: Yang
authors: Y
authors: Wang
authors: Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China.
authors: Linyong
authors: L
authors: Zhu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006820:Hyaluronic Acid / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D007097:Imines / Q000737:chemistry*; D013058:Mass Spectrometry; D051379:Mice; D009578:Nitrobenzenes / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D014466:Ultraviolet Rays; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D007097:Imines; D009578:Nitrobenzenes; D011506:Proteins; D006820:Hyaluronic Acid; C036077:nitrobenzene
keywords: hydrogels; imine crosslinking; o-nitrobenzene; photogelation; tissue integration