title: Seroprevalence of antibodies against GII.4 norovirus among children in Pune, India.
abstract: This study reports the seroprevalence of antibodies against GII.4 norovirus among children (≤5 years) in Pune, India. Of 191 serum specimens, 98 (51.3%) tested positive with 61, 34 and 3 having IgG, IgG-IgA and IgG-IgA-IgM, respectively. Histoblood group antigen (HBGA)-blocking antibodies were detected in 33 of the 54 tested positive specimens. IgG and blocking antibody prevalence and titer varied with age and was lowest among children aged 6-23 months. Antibody-positive children, suggesting past norovirus exposure, showed significantly lower faecal norovirus RNA detection rate than antibody-negative children. Further investigation of the seroepidemiology of norovirus infections in India is warranted. J. Med. Virol. 88:1636-1640, 2016. © 2016 Wiley Periodicals, Inc.
authors: Enteric Viruses Group, National Institute of Virology, Pune, India.
authors: Ruta
authors: R
authors: Kulkarni
authors: Hepatitis Group, National Institute of Virology, Pune, India.
authors: Kavita
authors: K
authors: Lole
authors: Enteric Viruses Group, National Institute of Virology, Pune, India.
authors: Shobha D
authors: SD
authors: Chitambar
mesh_terms: D019138:Antibodies, Blocking / Q000097:blood / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood*; D017250:Caliciviridae Infections / Q000453:epidemiology* / Q000276:immunology; D002675:Child, Preschool; D005243:Feces / Q000821:virology*; D005260:Female; D005759:Gastroenteritis / Q000276:immunology / Q000821:virology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D029322:Norovirus / Q000276:immunology*; D012367:RNA, Viral / Q000302:isolation & purification; D016036:Seroepidemiologic Studies
chemical_list: D019138:Antibodies, Blocking; D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral
keywords: HBGA-blocking antibody; IgA; IgG; IgM; protection