title: Depth and Patterns of Adnexal Involvement in Primary Extramammary (Anogenital) Paget Disease: A Study of 178 Lesions From 146 Patients.
abstract: Extramammary Paget disease (EMPD) is a rare neoplasm usually presenting in the anogenital area, most commonly in the vulva. Adnexal involvement in primary EMPD is a very common feature and serves as a pathway for carcinoma to spread into deeper tissue. The depth of carcinomatous spread along the appendages and the patterns of adnexal involvement were studied in 178 lesions from 146 patients with primary EMPD. Hair follicles and eccrine ducts were the adnexa most commonly affected by carcinoma cells. The maximal depth of involvement was 3.6 mm in this series. When planning topical therapy or developing novel local treatment modalities for EMPD, this potential for significant deep spread along adnexa should be taken into account.
authors: *Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint-Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Russia; ‡Department of Pathology, Petrov's Research Institute of Oncology, Saint Petersburg, Russia; §PathWest Laboratory Medicine WA, King Edward Memorial Hospital, Perth, Western Australia, Australia; ¶PathWest Laboratory Medicine WA, QEII Medical Centre, Nedlands, WA, Australia; ‖University of Western Australia, School of Pathology and Laboratory Medicine, Nedlands, WA, Australia; **Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany; ††Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; ‡‡Bioptical Laboratory, Pilsen, Czech Republic; §§Miraca Life Science, Irving, TX; ¶¶Department of Pathology, Division of Dermatopathology, Medical College of Wisconsin, Milwaukee, WI; ‖‖Department of Obstetrics and Gynecology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic; ***Department of Pathology, Regional Hospital, Most, Czech Republic; and †††Dermatopathology Unit, Department of Dermatology, Zurich University Hospital, Zurich, Switzerland.
authors: Anastasia M
authors: AM
authors: Konstantinova
authors: Ksenya V
authors: KV
authors: Shelekhova
authors: Colin J
authors: CJ
authors: Stewart
authors: Dominic V
authors: DV
authors: Spagnolo
authors: Heinz
authors: H
authors: Kutzner
authors: Denisa
authors: D
authors: Kacerovska
authors: Jose A
authors: JA
authors: Plaza
authors: Saul
authors: S
authors: Suster
authors: Jiri
authors: J
authors: Bouda
authors: Michal
authors: M
authors: Pavlovsky
authors: Liubov
authors: L
authors: Kyrpychova
authors: Michal
authors: M
authors: Michal
authors: Emmanuella
authors: E
authors: Guenova
authors: Dmitry V
authors: DV
authors: Kazakov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001005:Anus Neoplasms / Q000473:pathology* / Q000628:therapy; D001706:Biopsy; D004439:Eccrine Glands / Q000473:pathology*; D005060:Europe; D005260:Female; D018859:Hair Follicle / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018294:Neoplasms, Adnexal and Skin Appendage / Q000473:pathology* / Q000628:therapy; D010145:Paget Disease, Extramammary / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D013544:Sweat Gland Neoplasms / Q000473:pathology* / Q000628:therapy; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000628:therapy; D014904:Western Australia