title: Data for induction of cytotoxic response by natural and novel quercetin glycosides.
abstract: The flavonoids quercetin, and its natural glycosides isoquercetin and rutin, are phytochemicals commonly consumed in plant-derived foods and used as a food beverage additive. Semi-synthetic maltooligosyl isoquercetin, monoglucosyl rutin and maltooligosyl rutin were developed by synthetic glycosylation to improve their water solubility for food and other applications. Using a system of Chinese hamster ovary (CHO) cells, this study examined the differences in cytotoxic responses induced by short and continuous exposure of natural and synthetic flavonoids. By assessing cell viability after short term exposure and clonogenicity with continuous exposure under various flavonoids, quercetin aglycone is confirmed to be the most cytotoxic flavonoids, and heavily glucosylated maltooligosyl rutin was the least cytotoxic. The other heavily glucosylated maltooligosyl isoquercetin showed intermediate cytotoxicity and similar toxicity as isoquercetin.
authors: Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA.
authors: Alexis H
authors: AH
authors: Haskins
authors: Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA.
authors: Cathy
authors: C
authors: Su
authors: Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA.
authors: Anya
authors: A
authors: Engen
authors: Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA.
authors: Victoria A
authors: VA
authors: Salinas
authors: Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA.
authors: Junko
authors: J
authors: Maeda
authors: Graduate School of Engineering, The University of Tokyo, Tokyo 113-8685, Japan.
authors: Mitsuru
authors: M
authors: Uesaka
authors: Graduate School of Engineering, The University of Tokyo, Tokyo 113-8685, Japan; Research and Development Group, Toyo Sugar Refining Co. Ltd., Tokyo 103-0046, Japan.
authors: Yasushi
authors: Y
authors: Aizawa
authors: Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA.
authors: Takamitsu A
authors: TA
authors: Kato
keywords: Cytotoxicity; Flavonoid; Isoquercetin; Quercetin; Rutin