title: [Prophylactic use of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia: a randomized, double-blinded, placebo-controlled study].
abstract: BACKGROUND
  Succinylcholine is commonly used to achieve profound neuromuscular blockade of rapid onset and short duration.
  
  
  OBJECTIVE
  The present study compared the efficacy of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia.
  
  
  METHODS
  Prospective, randomized, placebo controlled, double blinded study.
  
  
  METHODS
  Patients of both genders undergoing elective spine surgery were randomly assigned to two groups. Patients in Group P (pregabalin group) received 150mg of pregabalin orally 1h prior to induction of anesthesia with sips of water and patients in Group C (control group) received placebo. Anesthesia was induced with fentanyl 1.5mcg/kg, propofol 1.5-2.0mg/kg followed by succinylcholine 1.5mg/kg. The intensity of fasciculations was assessed by an observer blinded to the group allotment of the patient on a 4-point scale. A blinded observer recorded postoperative myalgia grade after 24h of surgery. Patients were provided patient-controlled analgesia with fentanyl for postoperative pain relief.
  
  
  RESULTS
  Demographic data of both groups were comparable (p>0.05). The incidence of muscle fasciculation's was not significant between two groups (p=0.707), while more patients in group C had moderate to severe fasciculation's compared to group P (p=0.028). The incidence and severity of myalgia were significantly lower in group P (p<0.05).
  
  
  CONCLUSIONS
  Pregabalin 150mg prevents succinylcholine-induced fasciculations and myalgia and also decreases the fentanyl consumption in elective sine surgery.
authors: Apollo Hospitals Bilaspur, Chhattisgarh, Índia. Electronic address: drvinit75@gmail.com.
authors: Vinit K
authors: VK
authors: Srivastava
authors: Himalayan Institute of Medical Sciences, Dehradun, Índia.
authors: Sanjay
authors: S
authors: Agrawal
authors: Apollo Hospitals Bilaspur, Chhattisgarh, Índia.
authors: Vikrant K
authors: VK
authors: Nimbhorkar
authors: Apollo Hospitals Bilaspur, Chhattisgarh, Índia.
authors: Abhishek
authors: A
authors: Mishra
authors: Apollo Hospitals Bilaspur, Chhattisgarh, Índia.
authors: Sunil
authors: S
authors: Sharma
authors: Apollo Hospitals Bilaspur, Chhattisgarh, Índia.
authors: Prasanta K
authors: PK
authors: Panda
keywords: Fasciculation; Fasciculação; Mialgia; Myalgia; Pregabalin; Pregabalina; Succinilcolina; Succinylcholine