title: How to Manage Electrical Status Epilepticus in Sleep.
abstract: Electrical status epilepticus in sleep is an age-dependent syndrome with the characteristic pattern of continuous spike and waves during non-rapid eye movement sleep. Most children can present developmental deterioration. The demonstration of the EEG pattern has to rely on all night long EEG recordings. A comprehensive neuropsychologic evaluation with periodic reassessment should be performed. For the idiopathic forms of electrical status epilepticus in sleep, clobazam could be considered as the first-line therapy; in the other cases, corticosteroids, in particular intravenous methylprednisolone pulse therapy, remain the most effective and should be considered the therapy of choice.
authors: *Department of Child Neurology and Psychiatry, C. Mondino National Neurological Institute, Pavia, Italy; and †Brain and Behaviour Department, University of Pavia, Pavia, Italy.
authors: Pierangelo
authors: P
authors: Veggiotti
authors: Maria Carmela
authors: MC
authors: Pera
authors: Sara
authors: S
authors: Olivotto
authors: Valentina
authors: V
authors: De Giorgis
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D004569:Electroencephalography / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D017286:Polysomnography / Q000379:methods; D020178:Sleep Disorders, Circadian Rhythm / Q000175:diagnosis* / Q000628:therapy*; D013226:Status Epilepticus / Q000175:diagnosis* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants