title: Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base.
abstract: Most cases of adenoid cystic carcinoma (ACC) of the tongue base are radioresistant, and are diagnosed in the advanced stage. Therefore, we evaluated the safety and efficacy of carbon ion radiotherapy (C-ion RT) for locally advanced ACC of the tongue base.
  
  
  
  Eighteen patients with ACC of the tongue base were treated with C-ion RT between May 2002 and April 2014. Seventeen patients had T4a disease and 1 patient had T2 disease before C-ion RT.
  
  
  
  The median follow-up period was 57 months (range, 10-132 months). The 5-year local control rate was 92%. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 72% and 44%, respectively. Regarding late reactions, 2 patients developed grade 3 mandible osteoradionecrosis, and 1 had grade 3 hemorrhage of the tongue base.
  
  
  
  C-ion RT was effective with acceptable toxicities for locally advanced ACC of the tongue base. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2122-E2126, 2016.
authors: Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan.
authors: Masashi
authors: M
authors: Koto
authors: Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan.
authors: Azusa
authors: A
authors: Hasegawa
authors: Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan.
authors: Ryo
authors: R
authors: Takagi
authors: Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan.
authors: Hiroaki
authors: H
authors: Ikawa
authors: Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan.
authors: Kensuke
authors: K
authors: Naganawa
authors: Nagoya Proton Therapy Center, Nagoya, Japan.
authors: Jun-Etsu
authors: JE
authors: Mizoe
authors: Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan.
authors: Keiichi
authors: K
authors: Jingu
authors: Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan.
authors: Hirohiko
authors: H
authors: Tsujii
authors: Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan.
authors: Hiroshi
authors: H
authors: Tsuji
authors: Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan.
authors: Tadashi
authors: T
authors: Kamada
authors: Department of Otolaryngology, Chiba University School of Medicine, Chiba, Japan.
authors: Yoshitaka
authors: Y
authors: Okamoto
mesh_terms: D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000532:radiotherapy*; D018572:Disease-Free Survival; D005260:Female; D063193:Heavy Ion Radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000532:radiotherapy*; D055815:Young Adult
keywords: adenoid cystic carcinoma; carbon ion radiotherapy; head and neck cancer; radiotherapy; tongue base