title: IgE and FcεRI are highly expressed on innate cells in psoriasis.
abstract: BACKGROUND
  Although elevated serum IgE levels have been reported in psoriasis, the role of IgE in psoriasis still needs to be clarified.
  
  
  OBJECTIVE
  To analyse serum total IgE levels in addition to the presence and distribution of IgE and FcεRI in psoriatic lesions, and to investigate alteration of IgE and FcεRI after successful systemic treatment.
  
  
  METHODS
  Total serum IgE levels were determined using enzyme-linked immunosorbent assay. The expression and localization of IgE and FcεRI was investigated using immunohistochemistry and double immunofluorescence.
  
  
  RESULTS
  Elevated total serum IgE levels were found in 39% of patients with psoriasis. The levels of total serum IgE were significantly higher in male patients compared with female patients. Furthermore, total serum IgE levels decreased after successful systemic treatment. A positive correlation between IgE+ and FcεRI+ cells and a significant increase of these cells was found in psoriatic lesions when compared with normal skin. Interestingly, IgE+ and FcεRI+ cells decreased significantly after successful therapy with ustekinumab. IgE and FcεRI were coexpressed on mast cells, epidermal Langerhans cells, dermal dendritic cells, macrophages and a small number of neutrophils.
  
  
  CONCLUSIONS
  IgE might participate in the development of psoriasis by activating FcεRI-bearing cells.
authors: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: K-X
authors: KX
authors: Yan
authors: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Q
authors: Q
authors: Huang
authors: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: X
authors: X
authors: Fang
authors: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Z-H
authors: ZH
authors: Zhang
authors: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: L
authors: L
authors: Han
authors: Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
authors: K
authors: K
authors: Gadaldi
authors: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: K-F
authors: KF
authors: Kang
authors: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Z-Z
authors: ZZ
authors: Zheng
authors: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: J-H
authors: JH
authors: Xu
authors: Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
authors: N
authors: N
authors: Yawalkar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007073:Immunoglobulin E / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology*; D017455:Receptors, IgE / Q000378:metabolism*; D012867:Skin / Q000276:immunology; D055815:Young Adult
chemical_list: D017455:Receptors, IgE; D007073:Immunoglobulin E