title: Evaluation of muscle strength and manual dexterity in patients with Charcot-Marie-Tooth disease.
abstract: METHODS
  Matched pair study.
  
  
  BACKGROUND
  Differences in hand-muscle strength/dexterity between dominant (DH) and non-dominant (NDH) hand in Charcot-Marie-Tooth disease (CMT) are not well understood.
  
  
  OBJECTIVE
  To compare muscle strength/dexterity between DH and NDH and to correlate manual dexterity, strength and sensory function.
  
  
  METHODS
  Thirty CMT patients were studied using functional muscle testing (FMT) and strength (dynamometry), dexterity (the Nine Hole Peg Test [NHPT]), and Jebsen-Taylor Hand Function [JTT]), and sensory function (the Nottingham Sensory Assessment [NSA]).
  
  
  RESULTS
  Scores were worse for DH than NDH on FMT (p = 0.043) and NHPT (p = 0.014) but not on JTT (p = 0.098), handgrip strength (p = 0.710) or tripod pinch (p = 0.645). NSA did not correlate significantly with any tests (p's0.05).
  
  
  CONCLUSIONS
  In CMT disease, DH appears more impaired than NDH in terms of function and dexterity. Greater muscle weakness in DH may also emerge as CMT progresses.
  
  
  METHODS
  3b.
authors: Department of Rehabilitation and Sports Medicine, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic. Electronic address: alenamudr@me.com.
authors: Alena
authors: A
authors: Kobesova
authors: Department of Rehabilitation and Sports Medicine, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
authors: Marcela
authors: M
authors: Nyvltova
authors: Department of Child Neurology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
authors: Josef
authors: J
authors: Kraus
authors: Department of Rehabilitation and Sports Medicine, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
authors: Pavel
authors: P
authors: Kolar
authors: School of Aging Studies, University of South Florida, Tampa, FL, USA.
authors: Angela
authors: A
authors: Sardina
authors: Department of Neurology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
authors: Radim
authors: R
authors: Mazanec
authors: School of Aging Studies, University of South Florida, Tampa, FL, USA.
authors: Ross
authors: R
authors: Andel
mesh_terms: D000328:Adult; D000368:Aged; D002607:Charcot-Marie-Tooth Disease / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology*; D053581:Muscle Strength Dynamometer; D009460:Neurologic Examination; D055815:Young Adult
keywords: Charcot-Marie-Tooth disease; Hand strength; Hereditary motor and sensory neuropathy; Manual dexterity; Sensory function