title: Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes).
abstract: Hericium erinaceus is a culinary-medicinal mushroom that is used in traditional medicine, in folk medicine, and as medicinal cuisine in Asian countries such as China, Japan, and Korea. H. erinaceus exhibits various pharmacological properties, such as anti-cancer, immunomodulation, anti-dementia, and anti-gastric ulcer effects. The extracts of the fruiting body of H. erinaceus demonstrate anti-gastritis activity. However, the active principle in the extract, as well as the mechanism to treat gastric ulcers, remains uncertain. The current study aims to identify the active component, with anti-gastric ulcer function, from the extracts of the H. erinaceus mycelium culture. In the experiment, anti-gastric ulcer activity was evaluated using an ethanol-induced ulcer model in mice and with an 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay using MC cell lines. The results suggest that the polysaccharide fraction can significantly decrease the ulcerated area compared with the control group and the effect is fairly dose dependent, irrespective of animal or cell experiments. These results indicate that the polysaccharide fraction is the active component of the H. erinaceus mycelium culture, which protects against gastric ulcers.
authors: Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, China; International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China.
authors: Mingxing
authors: M
authors: Wang
authors: Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, China; Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
authors: Tetsuya
authors: T
authors: Konishi
authors: Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
authors: Yang
authors: Y
authors: Gao
authors: Research and Development Center, Changchun University of Chinese Medicine, Changchun, China.
authors: Duoduo
authors: D
authors: Xu
authors: International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China; Research and Development Center, Changchun University of Chinese Medicine, Changchun, China.
authors: Qipin
authors: Q
authors: Gao
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D001487:Basidiomycota / Q000737:chemistry*; D004195:Disease Models, Animal; D005260:Female; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D008297:Male; D051379:Mice; D025282:Mycelium / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification; D011134:Polysaccharides / Q000008:administration & dosage* / Q000302:isolation & purification; D013276:Stomach Ulcer / Q000188:drug therapy*
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D011134:Polysaccharides