title: [The application of the combined resonance-wave therapy for the treatment of the patients presenting with chronic bacterial prostatitis].
abstract: Recent studies have confirmed the anti-inflammatory and trophic effects of low-intensity electromagnetic radiation with a frequency of 1 GHz in the microwave range in a number of inflammatory diseases. The results of experimental investigations demonstrating the influence of this physical factor on water molecules provide a basis for resonance-microwave therapy. Aim. The objective of the present work was evaluate the effectiveness of this physiotherapeutic method used for the treatment of 50 patients with chronic bacterial prostatitis (CBP). Patients and methods. All the patients were randomly divided into two groups. The main group included 26 patients, and the control group was comprised of 24 patients. The patients of the latter group were given only basic drug therapy, while those in the main group were additionally treated by means of resonance-microwave therapy with the use of the Akvaton-02 apparatus (Russia). Dynamics of the clinical symptoms and the quality of life were evaluated based on the results of microscopic and bacteriological examination of the prostate secretion, measurements of the blood levels of tumor necrosis factor TNF-alpha and interleukin-1beta.
  
  
  RESULTS
  The study has demonstrated that resonance-microwave therapy resulted in positive dynamics of pain and dysuric syndromes that was especially well apparent in the patients of the main group. This observation was confirmed by a significant change in the severity of the clinical symptoms of the disease estimated based on the NIH-CPSI scale and in the quality of life (QOL) of the patients. The microscopic and bacteriological examination of the prostate secretion revealed the pronounced anti-inflammatory and antibacterial effects in 19 (73.61%) patients of the main group compared with 16 (66.7%) patients in the control group. In addition, the low-intensity resonance-microwave therapy was shown to produce beneficial effect on the levels of pro-inflammatory cytokines in the blood of patients presenting with chronic bacterial prostatitis. The decline the TNF-alpha and IL-1beta blood levels was documented in the patients of both groups, but only in the main group the level of TNF-alpha was significantly different from its baseline value. In the majority of the patients, the above changes persisted for two months.
  
  
  CONCLUSIONS
  The present study has demonstrated the increased clinical effectiveness of resonance-microwave therapy in the patients suffering from chronic bacterial prostatitis in comparison with baseline drug therapy and thereby confirmed the feasi bility of low-intensity electromagnetic radiation with a frequency of 1 GHz for the treatment of this pathology.
authors: Federal state budgetary institution 'Russian Research Centre of Medical Rehabilitation and Balneotherapy', Russian Ministry of Health, Moscow, Russian Federation, 121099.
authors: V A
authors: VA
authors: Kiyatkin
authors: Federal state budgetary institution 'Russian Research Centre of Medical Rehabilitation and Balneotherapy', Russian Ministry of Health, Moscow, Russian Federation, 121099.
authors: T V
authors: TV
authors: Konchugova
authors: Federal state budgetary institution 'Russian Research Centre of Medical Rehabilitation and Balneotherapy', Russian Ministry of Health, Moscow, Russian Federation, 121099.
authors: M Yu
authors: MY
authors: Yakovlev
authors: Federal state budgetary institution 'Russian Research Centre of Medical Rehabilitation and Balneotherapy', Russian Ministry of Health, Moscow, Russian Federation, 121099.
authors: A D
authors: AD
authors: Bobkov
mesh_terms: D000328:Adult; D003972:Diathermy; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D008872:Microwaves; D011472:Prostatitis / Q000188:drug therapy / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha