title: Serum Antibodies to Glycans in Peripheral Neuropathies.
abstract: In peripheral neuropathies, such as sensorimotor neuropathies, motor neuron diseases, or the Guillain-Barré syndrome, serum antibodies recognizing saccharide units, portion of oligosaccharides, or oligosaccharide chains, have been found. These antibodies are called anti-glycosphingolipid (GSL) or anti-ganglioside antibodies. However, the information on the aglycone carrying the hydrophilic oligosaccharide remains elusive. The absolute and unique association of GSL to the onset, development and symptomatology of the peripheral neuropathies could be misleading. Here, we report some thoughts on the matter.
authors: Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy. sandro.sonnino@unimi.it.
authors: Sandro
authors: S
authors: Sonnino
authors: Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
authors: Elena
authors: E
authors: Chiricozzi
authors: Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
authors: Maria Grazia
authors: MG
authors: Ciampa
authors: Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
authors: Laura
authors: L
authors: Mauri
authors: Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
authors: Alessandro
authors: A
authors: Prinetti
authors: FIDIA Farmaceutici, Abano Terme, Padua, Italy.
authors: Gino
authors: G
authors: Toffano
authors: Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
authors: Massimo
authors: M
authors: Aureli
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D005732:Gangliosides / Q000097:blood; D006028:Glycosphingolipids / Q000097:blood*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000175:diagnosis; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000097:blood* / Q000175:diagnosis*; D011134:Polysaccharides / Q000097:blood*
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; D006028:Glycosphingolipids; D011134:Polysaccharides
keywords: Glycoconjugates; Mimicry; Oligosaccharides; Peripheral neuropathies; Serum antibodies