title: [STATE OF NONALLERGIC HYPERSENSITIVITY UNDER THE EXPOSURE TO ADVERSE ENVIRONMENTAL FACTORS].
abstract: Now a number of allergopatologies is shown to be formed as non-allergic hypersensitivity. Research of this state is especially important when studying a question of formation of a condition of a chemical sensitization in response to the contact of a human body with chemical pollutants. For diagnostics of reactions of non-allergic hypersensitivity the test was developed for an assessment of activation of basophiles by specific allergens (the test of activation of basophiles by method of a flowing cytometry Flow Cast® (BD FACSCalibur)). It is possible to judge by activation on an expression of some receptors on a surface of these cages (CD63). Examination of a group of persons, having continuous contact with means of household chemicals was performed. In 54.5% of the examined persons the percent of CD63-of nonspecific activated cages was revealed to be at the level of 16-65% that gives the grounds to assume existence of a condition of not allergic hypersensitivity. Thus, the test of activation of basophiles by method of a flowing cytometry can be used for a differentiation of an IgE-dependent allergy from a condition of non-allergic hypersensitivity.
authors: V N
authors: VN
authors: Fedoseeva
authors: A K
authors: AK
authors: Makovetskaya
authors: T G
authors: TG
authors: Fedoskova
authors: O V
authors: OV
authors: Mislavskiy
authors: N V
authors: NV
authors: Stomakhina
mesh_terms: D001491:Basophils / Q000276:immunology / Q000473:pathology; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D007159:Immunologic Tests / Q000379:methods
chemical_list: D007073:Immunoglobulin E