title: Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling.
abstract: The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm(-1) ; 3.85 mm(-1) ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor was visible in two subsequent histopathological prostate slices. This analysis could be performed in 3 patients. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.23 mm(-1) ; 4.11 mm(-1) ; p < 0.0001) for all patients grouped together. The area under the ROC curve was 0.89. Functional OCT of the prostate has shown to differentiate between cancer and healthy prostate tissue. The optical attenuation coefficient in malignant tissue was significantly higher in malignant tissue compared to benign prostate tissue. Further studies are required to validate these initial results in a larger group of patients with a more tailored histopathology matching protocol.
authors: Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ Amsterdam Z.O., The Netherlands. b.g.muller@amc.uva.nl.
authors: Berrend G
authors: BG
authors: Muller
authors: Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ Amsterdam Z.O., The Netherlands.|Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands.
authors: Daniel M
authors: DM
authors: de Bruin
authors: Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands.
authors: Martin J
authors: MJ
authors: Brandt
authors: Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ Amsterdam Z.O., The Netherlands.
authors: Willemien
authors: W
authors: van den Bos
authors: Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ Amsterdam Z.O., The Netherlands.
authors: Suzanne
authors: S
authors: van Huystee
authors: Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands.
authors: D J
authors: DJ
authors: Faber
authors: Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.
authors: Dilaria
authors: D
authors: Savci
authors: Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ Amsterdam Z.O., The Netherlands.
authors: Patricia J
authors: PJ
authors: Zondervan
authors: Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ Amsterdam Z.O., The Netherlands.
authors: Theo M
authors: TM
authors: de Reijke
authors: Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ Amsterdam Z.O., The Netherlands.
authors: M Pilar
authors: MP
authors: Laguna-Pes
authors: Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands.
authors: Ton G
authors: TG
authors: van Leeuwen
authors: Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands.
authors: Jean J M C H
authors: JJ
authors: de la Rosette
mesh_terms: D006801:Humans; D008297:Male; D009339:Needles; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence
keywords: Diagnosis; Imaging; Optical Coherence Tomography; Prostate cancer