title: Effects of cilostazol on fracture healing: an experimental study.
abstract: OBJECTIVE
  The aim of this experimental study was to examine the clinical, radiological and histological effects of cilostazol on fracture healing.
  
  
  METHODS
  A total of 60 Wistar albino male rats were divided into 2 groups: the study group (cilostazol) and the control group. Under general anesthesia, using a blunt-ended guillotine, standard closed shaft fractures were formed on the 3-point principle in the left femurs. Starting on the same day after the fracture was formed until sacrifice, the study group animals were administered with cilostazol (50 mg/kg/day, oral tablet). An equal number of rats from both control and study groups were sacrificed on the 7th, 14th, and 21st days after fracture formation, and the bone union tissue was examined clinically, radiologically and histologically.
  
  
  RESULTS
  The use of cilostazol was not determined to have any significant effect clinically or radiologically on fracture healing (p>0.05). According to the histological findings, at the end of the first week, the amount of union in the cilostazol group was observed to be significantly greater (p<0.05). At the end of the third week, no significant difference was determined between the control and study groups (p>0.05).
  
  
  CONCLUSIONS
  In the long term, cilostazol did not show any positive effect on fracture healing clinically, radiologically or histologically.
authors: Gaziantep Şehit Kamil State Hospital, Department of Orthopaedics and Traumatology, Gaziantep, Turkey.
authors: Taner
authors: T
authors: Alıç
authors: Kayseri Training and Research Hospital, Department of Orthopaedics and Traumatology, Kayseri, Turkey.
authors: Alper
authors: A
authors: Çıraklı
authors: Samsun Special Medicana Hospital, Department of Orthopaedics and Traumatology, Samsun, Turkey.
authors: Yılmaz
authors: Y
authors: Şahin
authors: Ondokuz Mayıs University Faculty of Medicine, Department of Orthopaedics and Traumatology, Samsun, Turkey.
authors: Yılmaz
authors: Y
authors: Tomak
mesh_terms: D000818:Animals; D000077407:Cilostazol; D005264:Femoral Fractures / Q000503:physiopathology / Q000628:therapy; D005269:Femur / Q000098:blood supply; D017102:Fracture Healing / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013777:Tetrazoles / Q000494:pharmacology*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D013777:Tetrazoles; D014665:Vasodilator Agents; D000077407:Cilostazol