title: Imaging-guided photoacoustic drug release and synergistic chemo-photoacoustic therapy with paclitaxel-containing nanoparticles.
abstract: Here, a novel triggered drug release modality was developed for oncotherapy. Paclitaxel (PTX), perfluorohexane (PFH) and gold nanorods (AuNRs) loaded nanoparticles (PTX-PAnP) were synthesized. Folic acid (FA) conjugated PTX-PAnP (PTX-PAnP-FA) could be selectively taken into folate receptor-overexpressed tumor cells. Upon pulsed laser irradiation, the PTX-PAnP-FA could be rapidly destructed because of the PFH vaporization, resulting in fast drug release, which induced apoptosis of cancer cells efficiently. Stimulated fragmentation of the PTX-PAnP-FA nanoparticles can facilitate multiple mechanisms such as bubble implosion, shockwave generation, and sonoporation that further enhance the therapeutic efficiency. The in vivo therapy study further confirmed this new approach resulted in efficient tumor suppression. The results demonstrate a unique drug release mechanism based on photoacoustic effect. It provides an all-in-one platform for photoacoustic image-guided drug release and synergistic chemo-photoacoustic therapy.
authors: MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
authors: Junping
authors: J
authors: Zhong
authors: MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
authors: Sihua
authors: S
authors: Yang
authors: MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
authors: Liewei
authors: L
authors: Wen
authors: MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China. Electronic address: xingda@scnu.edu.cn.
authors: Da
authors: D
authors: Xing
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D005466:Fluorocarbons / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005492:Folic Acid / Q000737:chemistry; D006046:Gold / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006367:HeLa Cells; D006801:Humans; D028022:Low-Level Light Therapy / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D043942:Nanotubes / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D017239:Paclitaxel / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D061088:Photoacoustic Techniques / Q000379:methods; D014835:Volatilization
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005466:Fluorocarbons; D006046:Gold; D005492:Folic Acid; C078626:perflexane; D017239:Paclitaxel
keywords: Gold nanorods; Paclitaxel; Perfluorohexane; Photoacoustic