title: Surgical result of pterygium extended removal followed by fibrin glue-assisted amniotic membrane transplantation.
abstract: OBJECTIVE
  To report the recurrence rate and cosmetic results of conjunctival wound edge and caruncle, and complications after pterygium extended removal followed by fibrin glue-assisted amniotic membrane transplantation.
  
  
  METHODS
  A prospective interventional cohort study enrolled 57 (58 eyes) patients undergoing pterygium extended removal followed by fibrin glue-assisted amniotic membrane transplantation. All patients received postoperative follow-up for at least 12 months. Recurrence rate was graded from 1 to 4, and cosmetic results of conjunctival edge and caruncle were graded from 1 to 5.
  
  
  RESULTS
  The cohort included 48 eyes with nasal pterygium, 5 eyes with temporal pterygium, and 5 eyes with double pterygium. There were 81.0% (n=47), 0% (n=0), 12% (n=7), and 7% (n=4) of eyes with Grades 1-4 recurrence, respectively. The cosmetic results of conjunctival wound edge and caruncle in cases with nasal pterygium showed 59.3% (n=32), 14.8% (n=8), 9.3% (n=5), 16.6% (n=9), and 0% (n=0) of eyes with Grades 1-5 morphology, respectively. Overall, 5.1% (n=3), 3.4% (n=2), 3.4% (n=2), 3.4% (n=2), 1.7% (n=1), 6.9% (n=4), and 1.7% (n=1) of patients suffered from postoperative pyogenic granuloma, transient diplopia, permanent motility restriction, steroid glaucoma, fat prolapse, subamniotic membrane hemorrhage, and early detachment of amniotic membrane, respectively.
  
  
  CONCLUSIONS
  Pterygium extended removal followed by fibrin glue-assisted amniotic membrane transplantation results in low recurrence, satisfactory cosmetic results and a low incidence of additional complications.
authors: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
authors: Hsin-Yu
authors: HY
authors: Liu
authors: Department of Ophthalmology, Taipei County Hospital, Taipei County, Taiwan.
authors: Yuh-Fang
authors: YF
authors: Chen
authors: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
authors: Ta-Ching
authors: TC
authors: Chen
authors: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
authors: Po-Ting
authors: PT
authors: Yeh
authors: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Center of Corneal Tissue Engineering and Stem Cell Biology, National Taiwan University Hospital, Taipei, Taiwan.
authors: Fung-Rong
authors: FR
authors: Hu
authors: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Center of Corneal Tissue Engineering and Stem Cell Biology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: chenweili@ntu.edu.tw.
authors: Wei-Li
authors: WL
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000650:Amnion / Q000637:transplantation*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D011446:Prospective Studies; D011625:Pterygium / Q000601:surgery*; D012008:Recurrence; D013518:Surgery, Plastic; D013624:Taiwan; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive
keywords: amniotic membrane transplantation; caruncle; fibrin glue; pterygium; recurrence