title: Glucose-functionalized amino-OPEs as biocompatible photosensitizers in PDT.
abstract: Photodynamic therapy (PDT) is a minimally invasive procedure that can provide a selective eradication of neoplastic diseases by the combined effect of a photosensitizer, light and oxygen. New amino oligo(phenylene-ethynylene)s (OPEs), bearing hydrophilic glucoside terminations, have been prepared, characterized and tested as photosensitizers in PDT. The effectiveness of these compounds in combination with UVA light has been checked on two tumor cell lines (HEp-2 and HeLa cells, derived from a larynx carcinoma and a cervical carcinoma, respectively). The compounds triggered a mitotic blockage that led to the cell death, being the effect active up to 3 μm concentration. The photophysical properties of OPEs, such as high quantum yield, stability, singlet oxygen production, biocompatibility, easy cell-internalization and very good response even at low concentration, make them promising photosensitizers in the application of PDT.
authors: Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali- ChiBioFarAm, Università di Messina, Messina, Italy.
authors: Elisa
authors: E
authors: Deni
authors: Departamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Alicia
authors: A
authors: Zamarrón
authors: Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali- ChiBioFarAm, Università di Messina, Messina, Italy.
authors: Paola
authors: P
authors: Bonaccorsi
authors: Departamento de Química Orgánica, Universidad Autónoma de Madrid, Madrid, Spain.
authors: M
authors: M
authors: Carmen Carreño
authors: Departamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Ángeles
authors: Á
authors: Juarranz
authors: Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali- ChiBioFarAm, Università di Messina, Messina, Italy.
authors: Fausto
authors: F
authors: Puntoriero
authors: Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali- ChiBioFarAm, Università di Messina, Messina, Italy.
authors: Maria Teresa
authors: MT
authors: Sciortino
authors: Departamento de Química Orgánica, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address: maria.ribagorda@uam.es.
authors: María
authors: M
authors: Ribagorda
authors: Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali- ChiBioFarAm, Università di Messina, Messina, Italy. Electronic address: abarattucci@unime.it.
authors: Anna
authors: A
authors: Barattucci
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005947:Glucose / Q000737:chemistry*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
chemical_list: D000480:Alkynes; D001672:Biocompatible Materials; D004987:Ethers; D017319:Photosensitizing Agents; C436384:phenyleneethynylene; D005947:Glucose
keywords: Glucose base photosensitizers; Oligo(phenylene ethynylene); Phothodynamic therapy; Phothosensitizer; Singlet oxygen production