title: Analysis of Ion Transport through a Single Channel of Gramicidin A in Bilayer Lipid Membranes.
abstract: Ion transport through a single channel of gramicidin A (GA) within the bilayer lipid membrane (BLM) between two aqueous phases (W1 and W2) has been analyzed based on the electroneutrality principle. The single-channel current increases in proportion to the magnitude of the applied membrane potential and is also dependent on the permeability coefficients of electrolyte ions (K(+) and Cl(-)). By varying the ratio of the concentration of KCl in W1 to that in W2, the ratio of the diffusion coefficient of K(+) in the BLM to that of Cl(-) in the BLM can be evaluated.
authors: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University.
authors: Shintaro
authors: S
authors: Kubota
authors: Osamu
authors: O
authors: Shirai
authors: Yuki
authors: Y
authors: Kitazumi
authors: Kenji
authors: K
authors: Kano
mesh_terms: D004058:Diffusion; D004553:Electric Conductivity; D004563:Electrochemistry / Q000379:methods*; D004573:Electrolytes / Q000737:chemistry; D006096:Gramicidin / Q000737:chemistry*; D007477:Ions / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008564:Membrane Potentials; D010539:Permeability; D011189:Potassium Chloride / Q000737:chemistry; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D004573:Electrolytes; D007477:Ions; D008051:Lipid Bilayers; D014867:Water; D006096:Gramicidin; D011189:Potassium Chloride