title: Cyst aspiration or GnRH antagonist administration for ovarian cysts detected at the start of fresh in vitro fertilization cycles.
abstract: The primary objective of this study is to investigate the effect of transvaginal ultrasonogram (TVUS)-guided cyst aspiration or gonadotropin releasing hormone antagonist (GnRH-ant) administration for the management of solitary ovarian cysts detected at the start of in vitro fertilization (IVF) cycles on the outcomes of the same cycles. This is a single-center, retrospective, cohort study of patients who had TVUS-guided cyst aspiration or GnRH-ant treatment for ovarian cysts detected at the start of IVF during a 5-year period. Four hundred and three patients met inclusion criteria: 41 (10.2%) underwent cyst aspiration and 362 (89.2%) were treated with GnRH-ant. There was no difference in the demographics or baseline IVF cycle characteristics of the two groups. Patients treated with GnRH-ant had a longer duration of ovarian stimulation (10.8 ± 3.45 days versus 9.05 ± 4.06 days, p = 0.003) and required higher gonadotropin doses (3887.7 ± 1097.8 IU versus 3293.7 ± 990.5 IU; p = 0.01) compared with the cyst aspiration group. There was no difference in the clinical pregnancy (43.9% versus 41.4%), spontaneous miscarriage (9.76% versus 8.01%) and live birth (34.1% versus 33.4%) rates between the groups. Our findings suggest that cyst aspiration is comparable to GnRH-ant administration for the management of solitary ovarian cysts detected at the start of IVF cycles.
authors: a The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College , New York , NY , USA .
authors: Nigel
authors: N
authors: Pereira
authors: b Department of Obstetrics and Gynecology , Weill Cornell Medical College , New York , NY , USA , and.
authors: Selma
authors: S
authors: Amrane
authors: c Department of Obstetrics and Gynecology , North Shore Long Island Jewish Health Care System at Staten Island , Staten Island , NY , USA.
authors: Elie
authors: E
authors: Hobeika
authors: a The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College , New York , NY , USA .
authors: Jovana P
authors: JP
authors: Lekovich
authors: a The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College , New York , NY , USA .
authors: Pak H
authors: PH
authors: Chung
authors: a The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College , New York , NY , USA .
authors: Zev
authors: Z
authors: Rosenwaks
mesh_terms: D000328:Adult; D001707:Biopsy, Needle / Q000379:methods*; D019160:Endosonography; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D017063:Outcome Assessment, Health Care; D010048:Ovarian Cysts / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone
keywords: Cyst aspiration; GnRH antagonist; IVF; outcomes; ovarian cyst