title: Effect of sex in the MRMT-1 model of cancer-induced bone pain.
abstract: An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to model metastatic bone pain in vivo, and are commonly used in both males and females. Here we demonstrate that compared to male rats, female rats have an increased capacity for recovery following inoculation of MRMT-1 mammary cells, thus potentially causing a sex-dependent bias in interpretation of the data.
authors: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, 2100, Denmark.
authors: Sarah
authors: S
authors: Falk
authors: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, 2100, Denmark.
authors: Tamara
authors: T
authors: Al-Dihaissy
authors: Department of Radiology, Leiden University Medical Center, Leiden, 2333 ZA, Netherlands.
authors: Laura
authors: L
authors: Mezzanotte
authors: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, 2100, Denmark.
authors: Anne-Marie
authors: AM
authors: Heegaard
keywords: Cancer-induced bone pain; bioluminescence; in vivo model; pain behavior; sex differences; x-ray