title: HDL/ApoA-I: role in VWF-dependent thrombosis.
abstract: In this issue of Blood, Chung and colleagues demonstrate in vitro and in an animal model that von Willebrand factor (VWF) self-association under shear stress can be modulated by the high-density lipoprotein and apolipoprotein A-I (HDL/ApoA-I) complex, with significant reduction in the length and thickness of VWF fibers. These antiadhesive and antithrombotic properties of HDL/ApoA-I may connect the pathology of microvasculature with that of large vessels (atherosclerosis with arterial thrombosis) and might suggest novel approaches to these thrombotic disorders.
authors: UNIVERSITY OF MILAN.
authors: Augusto B
authors: http://orcid.org/0000-0003-4325-0918
authors: AB
authors: Federici
mesh_terms: D000818:Animals; D016632:Apolipoprotein A-I / Q000378:metabolism*; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism*; D010973:Platelet Adhesiveness; D013927:Thrombosis / Q000378:metabolism*; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D016632:Apolipoprotein A-I; D008075:Lipoproteins, HDL; D014841:von Willebrand Factor