title: Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy.
abstract: The intestinal immune system ingeniously balances the distinct responses of elimination and tolerance of non-self-substances for the creation and maintenance of homeostatic environments. Accumulating evidence has recently shown that various lipids, including dietary one, are involved in the regulation of intestinal immunity and are associated with biophylaxis and immune disorders. Recent advances in the lipidomics allow the identification of novel pathways of lipid metabolism and lipid metabolites for the control of intestinal immunity. In this paper, we describe the effects and functions of lipids, especially sphingolipids and new lipid metabolites originated from dietary oil on the immunomodulation and on the development and pathogenesis of allergic diseases in the intestine.
authors: Laboratory of Vaccine Materials, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan; Graduate School of Medicine, Osaka University, Suita, Japan; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan; Graduate School of Dentistry, Osaka University, Suita, Japan; Graduate School of Medicine, Kobe University, Kobe, Japan; Division of Mucosal Immunology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors: Jun
authors: J
authors: Kunisawa
authors: Division of Mucosal Immunology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors: Hiroshi
authors: H
authors: Kiyono
keywords: allergy and immunology; dietary fats; inflammation; lipid; vaccines