title: A Mapping Between Structural and Functional Brain Networks.
abstract: The relationship between structural and functional brain networks is still highly debated. Most previous studies have used a single functional imaging modality to analyze this relationship. In this work, we use multimodal data, from functional MRI, magnetoencephalography, and diffusion tensor imaging, and assume that there exists a mapping between the connectivity matrices of the resting-state functional and structural networks. We investigate this mapping employing group averaged as well as individual data. We indeed find a significantly high goodness of fit level for this structure-function mapping. Our analysis suggests that a functional connection is shaped by all walks up to the diameter in the structural network in both modality cases. When analyzing the inverse mapping, from function to structure, longer walks in the functional network also seem to possess minor influence on the structural connection strengths. Even though similar overall properties for the structure-function mapping are found for different functional modalities, our results indicate that the structure-function relationship is modality dependent.
authors: 1 Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology , The Netherlands .
authors: Jil
authors: J
authors: Meier
authors: 2 Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center , Amsterdam, The Netherlands .
authors: Prejaas
authors: P
authors: Tewarie
authors: 3 Department of Clinical Neurophysiology and Magnetoencephalography Center, Neuroscience Campus Amsterdam, VU University Medical Center , Amsterdam, The Netherlands .
authors: Arjan
authors: A
authors: Hillebrand
authors: 4 Department of Anatomy and Neurosciences, VU University Medical Center , Amsterdam, The Netherlands .|5 Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging/Massachusetts General Hospital , Boston, Massachusetts.
authors: Linda
authors: L
authors: Douw
authors: 3 Department of Clinical Neurophysiology and Magnetoencephalography Center, Neuroscience Campus Amsterdam, VU University Medical Center , Amsterdam, The Netherlands .
authors: Bob W
authors: BW
authors: van Dijk
authors: 5 Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging/Massachusetts General Hospital , Boston, Massachusetts.|6 Department of Radiology, Harvard Medical School , Boston, Massachusetts.
authors: Steven M
authors: SM
authors: Stufflebeam
authors: 1 Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology , The Netherlands .
authors: Piet
authors: P
authors: Van Mieghem
mesh_terms: D001921:Brain / Q000502:physiology; D001931:Brain Mapping / Q000379:methods*; D016208:Databases, Factual; D056324:Diffusion Tensor Imaging / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D015225:Magnetoencephalography / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods*; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D012146:Rest / Q000502:physiology; D013329:Structure-Activity Relationship
keywords: DT1; MEG; brain networks; fMRI; functional connectivity; functional networks; matrix mapping; structural connectivity; structural networks