title: B cells from relapsing remitting multiple sclerosis patients support neuro-antigen-specific Th17 responses.
abstract: B cells are highly potent antigen presenting cells of their cognate antigens. However, it remains unknown whether B cells can orchestrate Th17-mediated responses against neuro-antigens. We report that MS patients and healthy donors had a similar frequency of antigen-specific Th1 and Th17 cells, and distribution of T effector and T central memory cells. Notwithstanding these similarities, the application of an in vitro assay demonstrated that the B cells derived from a subset of MS patients exhibited the capability of coordinating Th17 responses directed toward neuro-antigens. These observations underscore the B cell's contribution to the putative underpinnings of multiple sclerosis.
authors: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: sara.ireland@utsouthwestern.edu.
authors: Sara J
authors: SJ
authors: Ireland
authors: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: alyssa.guzman@utsouthwestern.edu.
authors: Alyssa A
authors: AA
authors: Guzman
authors: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: elliot.frohman@utsouthwestern.edu.
authors: Elliot M
authors: EM
authors: Frohman
authors: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA; Department of Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: nancy.monson@utsouthwestern.edu.
authors: Nancy L
authors: NL
authors: Monson
mesh_terms: D015703:Antigens, CD; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D049109:Cell Proliferation / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D018920:Coculture Techniques; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000473:pathology*; D004676:Myelin Basic Protein / Q000276:immunology / Q000494:pharmacology*; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000276:immunology* / Q000494:pharmacology; D058504:Th17 Cells / Q000187:drug effects / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D016207:Cytokines; D004676:Myelin Basic Protein; D063308:Myelin-Oligodendrocyte Glycoprotein
keywords: B cells; Multiple sclerosis; Th17 cells