title: Urinary inorganic arsenic concentrations and semen quality of male partners of subfertile couples in Tokyo.
abstract: Inorganic arsenic (iAs) has been known as a testicular toxicant in experimental rodents. Possible association between iAs exposure and semen quality (semen volume, sperm concentration, and sperm motility) was explored in male partners of couples (n = 42) who visited a gynecology clinic in Tokyo for infertility consultation. Semen parameters were measured according to WHO guideline at the clinic, and urinary iAs and methylarsonic acid (MMA), and dimethylarsinic acid concentrations were determined by liquid chromatography-hydride generation-ICP mass spectrometry. Biological attributes, dietary habits, and exposure levels to other chemicals with known effects on semen parameters were taken into consideration as covariates. Multiple regression analyses and logistic regression analyses did not find iAs exposure as significant contributor to semen parameters. Lower exposure level of subjects (estimated to be 0.5 μg kg(-1) day(-1)) was considered a reason of the absence of adverse effects on semen parameters, which were seen in rodents dosed with 4-7.5 mg kg(-1).
authors: a Department of Environmental Studies , University of Tokyo , Kashiwa , Chiba , Japan.|b Department of Occupational and Environmental Health , Nagoya City University Graduate School of Medical Sciences , Mizuho , Nagoya , Japan.
authors: Tomoko
authors: T
authors: Oguri
authors: a Department of Environmental Studies , University of Tokyo , Kashiwa , Chiba , Japan.
authors: Jun
authors: J
authors: Yoshinaga
authors: a Department of Environmental Studies , University of Tokyo , Kashiwa , Chiba , Japan.
authors: Hiroki
authors: H
authors: Toshima
authors: c Japan Self-Defense Force Central Hospital , Setagaya , Tokyo , Japan.
authors: Yoshifumi
authors: Y
authors: Mizumoto
authors: d Tokuoka Ladies Clinic , Nakane , Tokyo , Japan.
authors: Shota
authors: S
authors: Hatakeyama
authors: d Tokuoka Ladies Clinic , Nakane , Tokyo , Japan.
authors: Susumu
authors: S
authors: Tokuoka
mesh_terms: D000328:Adult; D001151:Arsenic / Q000633:toxicity* / Q000652:urine*; D001152:Arsenicals / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D002101:Cacodylic Acid / Q000652:urine*; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D055101:Semen Analysis; D013081:Sperm Motility / Q000187:drug effects*; D014041:Tokyo
chemical_list: D001152:Arsenicals; D015415:Biomarkers; D002101:Cacodylic Acid; D001151:Arsenic
keywords: Infertility consultation; inorganic arsenic; methylarsonic acid; semen parameters; urine