title: [Impact of in utero exposure to pollutants on metabolic health in adults].
abstract: Obesity is a major public health problem because it is a risk factor for metabolic disorders including type 2 diabetes and cardiovascular disorders. Notably, pollutants endowed with endocrine disrupting activities have been charged to contribute to the etiology of obesity and type 2 diabetes, especially if exposure occurs during the early life shown to be a highly vulnerable window of time. An overview on endocrine disrupters in relation with the obesogen and metabolic disruption hypothesis is presented. Convincing data support the plausibility of such hypothesis. They also highlight the limits of the current threshold model used in risk assessment which focused on single chemicals and does not take into account potential effects of mixtures containing pollutants at environmental doses, e.g. the real life exposure. Certainly, the principle of precaution should guide the making of decisions especially when considering early life exposure.
authors: Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition, CarMeN, université Lyon 1, Inserm U1060, UMR Inra 1397, Insa-Lyon, faculté de médecine Lyon-sud-BP12, 165, chemin du Grand Revoyet, 69921 Oullins Cedex, France.
authors: Brigitte
authors: B
authors: Le Magueresse-Battistoni
authors: Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition, CarMeN, université Lyon 1, Inserm U1060, UMR Inra 1397, Insa-Lyon, faculté de médecine Lyon-sud-BP12, 165, chemin du Grand Revoyet, 69921 Oullins Cedex, France.
authors: Hubert
authors: H
authors: Vidal
authors: Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition, CarMeN, université Lyon 1, Inserm U1060, UMR Inra 1397, Insa-Lyon, faculté de médecine Lyon-sud-BP12, 165, chemin du Grand Revoyet, 69921 Oullins Cedex, France.
authors: Danielle
authors: D
authors: Naville
mesh_terms: D000328:Adult; D052244:Endocrine Disruptors / Q000633:toxicity; D004781:Environmental Exposure / Q000009:adverse effects; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006262:Health; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008659:Metabolic Diseases / Q000139:chemically induced*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants