title: Effects of traditional Korean medicine on anti-Müllerian hormone in patients with diminished ovarian reserve: A retrospective study.
abstract: OBJECTIVE
  The purpose of the present study is to retrospectively evaluate the effect of traditional Korean medicine (TKM) on ovarian reserve by measuring serum anti-Müllerian hormone (AMH) levels in patients with diminished ovarian reserve (DOR).
  
  
  METHODS
  We performed a retrospective chart review of patients with DOR who had received TKM for at least 2 months and had undergone serum AMH tests before and after TKM treatment. A total of 22 patients with DOR were included in the study.
  
  
  RESULTS
  There were no significant differences in AMH levels before and after TKM in all patients (n=22, p=0.237). However, when the study population was divided into two age groups (<38 (n=12) and ≥38 years (n=10)) to determine whether there was a age-related difference in the effect of TKM with DOR, a significant increase in AMH levels before and after TKM was observed in the age <38 (p<0.05).
  
  
  CONCLUSIONS
  TKM may provide an effective option for patients aged <38 years with DOR, but it should be interpreted cautiously as more rigorous research is needed. Further studies in a larger population are needed to confirm these results and to evaluate the effects of improved ovarian reserve on fertility outcomes following TKM in patients with DOR.
authors: Department of Korean Gynecology, Graduate School, Kyung Hee University, Seoul 130-702, Republic of Korea; Department of Korean Gynecology, Conmaul Hospital, Seoul 137-881, Republic of Korea. Electronic address: studd@naver.com.
authors: Junyoung
authors: J
authors: Jo
authors: Department of Korean Gynecology, Conmaul Hospital, Seoul 137-881, Republic of Korea. Electronic address: womannature@naver.com.
authors: Myung Ja
authors: MJ
authors: Kang
authors: Department of Korean Gynecology, Graduate School, Kyung Hee University, Seoul 130-702, Republic of Korea. Electronic address: hanbang9597@hanmail.net.
authors: Jin Moo
authors: JM
authors: Lee
authors: Department of Biofunctional Medicine & Diagnostics, College of Korean Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea. Electronic address: hyunho.kim@khu.ac.kr.
authors: Hyunho
authors: H
authors: Kim
authors: Clinical Research Division, Korea Institute of Oriental Medicine, Daejon 34054, Republic of Korea. Electronic address: breeze@kiom.re.kr.
authors: Ui Min
authors: UM
authors: Jerng
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D055670:Medicine, Korean Traditional; D065851:Ovarian Reserve / Q000502:physiology*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Anti-Müllerian hormone; Herbal medicine; Infertility; Ovarian reserve; Traditional Korean medicine