title: Blockade of dorsolateral pontine 5HT1A receptors destabilizes the respiratory rhythm in C57BL6/J wild-type mice.
abstract: The neurotransmitter serotonin (5HT) acting via 5HT1a receptors (5HT1aR) is a potent determinant of respiratory rhythm variability. Here, we address the 5HT1aR-dependent control of respiratory rhythm variability in C57BL6/J mice. Using the in situ perfused preparation, we compared the effects of systemic versus focal blockade of 5HT1aRs. Blocking 5HT1aRs in the Kölliker-Fuse nucleus (KFn) increased the occurrence of spontaneous apneas and accounted for the systemic effects of 5HT1aR antagonists. Further, 5HT1aRs of the KFn stabilized the respiratory rhythm's response to arterial chemoreflex perturbations; reducing the recovering time, e.g., the latency to return to the baseline pattern. Together, these results suggest that the KFn regulates both intrinsic and sensory determinants of respiratory rhythm variability.
authors: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.
authors: R R
authors: RR
authors: Dhingra
authors: Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
authors: M
authors: M
authors: Dutschmann
authors: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA. Electronic address: thomas.dick@case.edu.
authors: T E
authors: TE
authors: Dick
mesh_terms: D000818:Animals; D001049:Apnea / Q000139:chemically induced / Q000378:metabolism; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology; D003510:Cyclohexanes / Q000494:pharmacology*; D005260:Female; D065836:Kolliker-Fuse Nucleus / Q000187:drug effects* / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D057507:Mice, 129 Strain; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018373:Peripheral Nervous System Agents / Q000494:pharmacology; D010791:Phrenic Nerve / Q000187:drug effects / Q000502:physiology; D010879:Piperazines / Q000494:pharmacology*; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D012119:Respiration / Q000187:drug effects*; D058829:Serotonin 5-HT1 Receptor Antagonists / Q000494:pharmacology*; D012966:Sodium Cyanide / Q000494:pharmacology; D046509:Tissue Culture Techniques
chemical_list: D003510:Cyclohexanes; D018373:Peripheral Nervous System Agents; D010879:Piperazines; D058829:Serotonin 5-HT1 Receptor Antagonists; C112802:WAY 101363; D044282:Receptor, Serotonin, 5-HT1A; D012966:Sodium Cyanide
keywords: Control of breathing; Gain control; Kölliker-Fuse nuclei (KFN); Mecp2-deficient mice; Rett Syndrome; Serotonin (5-HT); Variability