title: Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.
abstract: In January 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development invited an expert panel to a workshop to address numerous knowledge gaps and to provide evidence-based guidelines for the diagnosis and management of pregnant women with what had been commonly called chorioamnionitis and the neonates born to these women. The panel noted that the term chorioamnionitis has been used to label a heterogeneous array of conditions characterized by infection and inflammation or both with a consequent great variation in clinical practice for mothers and their newborns. Therefore, the panel proposed to replace the term chorioamnionitis with a more general, descriptive term: "intrauterine inflammation or infection or both," abbreviated as "Triple I." The panel proposed a classification for Triple I and recommended approaches to evaluation and management of pregnant women and their newborns with a diagnosis of Triple I. It is particularly important to recognize that an isolated maternal fever is not synonymous with chorioamnionitis. A research agenda was proposed to further refine the definition and management of this complex group of conditions. This article provides a summary of the workshop presentations and discussions.
authors: Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; the Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas; the Department of Pediatrics, Columbia University, New York, New York; the Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois; the Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio; the Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico; and the Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah.
authors: Rosemary D
authors: RD
authors: Higgins
authors: George
authors: G
authors: Saade
authors: Richard A
authors: RA
authors: Polin
authors: William A
authors: WA
authors: Grobman
authors: Irina A
authors: IA
authors: Buhimschi
authors: Kristi
authors: K
authors: Watterberg
authors: Robert M
authors: RM
authors: Silver
authors: Tonse N K
authors: TNK
authors: Raju
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage; D015415:Biomarkers; D002821:Chorioamnionitis / Q000175:diagnosis / Q000628:therapy*; D019468:Disease Management; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D009626:Terminology as Topic
chemical_list: D000890:Anti-Infective Agents; D015415:Biomarkers