title: The second report of the Nordic Pediatric Renal Transplantation Registry 1997-2012: More infant recipients and improved graft survivals.
abstract: The NPRTSG has collected data on pediatric KTx since 1994. The registry archives information from all centers that perform pediatric KTx in Denmark, Finland, Norway, and Sweden and has 100% coverage. The first NPRTSG report was published in 1998 and was based on data collected in the 1982─1996 period. The present report provides data on 602 pediatric KTx in the Nordic countries from 1997 to 2012. Comparison of the patient demographics and one- and three-yr graft survivals between the two time cohorts revealed no significant change in the recipient and donor demographics. The number of transplantations increased by approximately 30%, doubling the recipients below the age of two yr. The use of Tac and mycophenolate as primary immunosuppression increased from practically 0% to 50% and 40%, respectively. The one- and three-yr graft survivals improved significantly (p < 0.001), especially among the youngest recipients with transplant from DD. In these patients, the one-yr survival improved from 70% to 94.6% and the three-yr graft survival from 60% to 94.6%, respectively. The improved graft survival may be at least partly due to changes in immunosuppression strategies, but also greater experience may also be of importance.
authors: Department of Pediatric Nephrology and Transplantation, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
authors: Timo
authors: T
authors: Jahnukainen
authors: Division of Specialised Medicine, Department of Pediatrics, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors: Anna
authors: A
authors: Bjerre
authors: Department of Transplantation Surgery, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors: Marie
authors: M
authors: Larsson
authors: Department of Pediatric Nephrology and Transplantation, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
authors: Juuso
authors: J
authors: Tainio
authors: Department of Nephrology, Odense University Hospital, Odense, Denmark.
authors: Helle C
authors: HC
authors: Thiesson
authors: Department of Pediatric Nephrology and Transplantation, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
authors: Hannu
authors: H
authors: Jalanko
authors: Department of Nephrology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
authors: Søren
authors: S
authors: Schwartz Sørensen
authors: Department of Transplantation Surgery, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors: Lars
authors: L
authors: Wennberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003718:Denmark; D005387:Finland; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D016030:Kidney Transplantation / Q000379:methods*; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000627:therapeutic use; D009664:Norway; D010372:Pediatrics / Q000379:methods*; D012042:Registries; D013548:Sweden; D016559:Tacrolimus / Q000627:therapeutic use; D014019:Tissue Donors; D066027:Transplant Recipients; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D016559:Tacrolimus
keywords: children; kidney; outcome; register; transplantation