title: Multifocal squamous cell carcinoma arising in a Favre-Racouchot lesion - report of two cases and review of the literature.
abstract: BACKGROUND
  Favre-Racouchot syndrome (nodular cutaneous elastosis with cysts and comedones) is a cutaneous disease characterized by coexistence of cysts, comedones and elastotic nodules in actinically damaged skin, typically on the face. Ultraviolet radiation plays a significant role in the development of the disease. Unilateral lesions have been described.
  
  
  METHODS
  In this report we present two cases of squamous cell carcinoma arising in a unilateral Favre-Racouchot plaque. Both patients, fair-skinned, elderly, with impaired immune function developed large, deep invasive tumors with perineural extension.
  
  
  CONCLUSIONS
  Squamous cell carcinomas of large size and prominent invasive growth developing in immunocompromised individuals carry poor prognosis with regard to recurrence rate and metastasis. Manifestations of malignancy as described in this report, indicate the importance of close follow-up of patients with Favre-Racouchot syndrome.
authors: Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;
authors: Natalja E
authors: NE
authors: Leeuwis-Fedorovich
authors: Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors: Markus
authors: M
authors: Starink
authors: Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;
authors: Allard C
authors: AC
authors: van der Wal
keywords: Favre-Racouchot disease; actinic keratosis; dermatoheliosis; immunosuppression; skin cancer; squamous cell carcinoma