title: Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis.
abstract: Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
authors: Vaccine and Gene Therapy Institute, Oregon Health & Science University (OHSU), 505 NW 185th Avenue, Beaverton, OR 97006, United States. Electronic address: tiffany.blair@agonox.com.
authors: Tiffany C
authors: TC
authors: Blair
authors: Vaccine and Gene Therapy Institute, Oregon Health & Science University (OHSU), 505 NW 185th Avenue, Beaverton, OR 97006, United States. Electronic address: manohara@ohsu.edu.
authors: Minsha
authors: M
authors: Manoharan
authors: Vaccine and Gene Therapy Institute, Oregon Health & Science University (OHSU), 505 NW 185th Avenue, Beaverton, OR 97006, United States. Electronic address: srawlingsd@gmail.com.
authors: Stephanie D
authors: SD
authors: Rawlings-Rhea
authors: Advanced Imaging Research Center, OHSU, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. Electronic address: taggei@ohsu.edu.
authors: Ian
authors: I
authors: Tagge
authors: Division of Neuroscience, Oregon National Primate Research Center (ONPRC), 505 NW 185th Avenue, Beaverton, OR 97006, United States. Electronic address: kohamas@ohsu.edu.
authors: Steven G
authors: SG
authors: Kohama
authors: Division of Neuroscience, Oregon National Primate Research Center (ONPRC), 505 NW 185th Avenue, Beaverton, OR 97006, United States. Electronic address: Hollister-smith@comcast.net.
authors: Julie
authors: J
authors: Hollister-Smith
authors: Division of Neuroscience, Oregon National Primate Research Center (ONPRC), 505 NW 185th Avenue, Beaverton, OR 97006, United States. Electronic address: fergusob@ohsu.edu.
authors: Betsy
authors: B
authors: Ferguson
authors: Department of Pathology, OHSU, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. Electronic address: woltjerr@ohsu.edu.
authors: Randall L
authors: RL
authors: Woltjer
authors: Department of Neurology, OHSU, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. Electronic address: frederim@ohsu.edu.
authors: Meredith C
authors: MC
authors: Frederick
authors: Advanced Imaging Research Center, OHSU, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. Electronic address: jim.pollaro@gmail.com.
authors: James
authors: J
authors: Pollaro
authors: Advanced Imaging Research Center, OHSU, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. Electronic address: rooneyw@ohsu.edu.
authors: William D
authors: WD
authors: Rooney
authors: Division of Neuroscience, Oregon National Primate Research Center (ONPRC), 505 NW 185th Avenue, Beaverton, OR 97006, United States. Electronic address: shermanl@ohsu.edu.
authors: Larry S
authors: LS
authors: Sherman
authors: Department of Neurology, OHSU, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. Electronic address: bourdette@ohsu.edu.
authors: Dennis N
authors: DN
authors: Bourdette
authors: Vaccine and Gene Therapy Institute, Oregon Health & Science University (OHSU), 505 NW 185th Avenue, Beaverton, OR 97006, United States; Division of Pathobiology and Immunology, ONPRC, 505 NW 185th Avenue, Beaverton, OR 97006, United States. Electronic address: wongs@ohsu.edu.
authors: Scott W
authors: SW
authors: Wong
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D002490:Central Nervous System / Q000473:pathology*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004679:Encephalomyelitis / Q000196:embryology* / Q000473:pathology*; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology; D008251:Macaca; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008840:Microfilament Proteins / Q000378:metabolism; D017628:Microglia / Q000378:metabolism / Q000473:pathology; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology*; D004676:Myelin Basic Protein / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D016207:Cytokines; D008840:Microfilament Proteins; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins
keywords: Demyelination; Inflammatory; Interleukin 17 (IL-17); Intrathecal IgG; Magnetic resonance imaging (MRI); Th1; Th17