title: Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides.
abstract: A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.
authors: a Department of Applied Chemistry and Pharmaceutics , Beijing Institute of Technology , Beijing 100081 , China.
authors: Yi-ning
authors: YN
authors: Wen
authors: a Department of Applied Chemistry and Pharmaceutics , Beijing Institute of Technology , Beijing 100081 , China.
authors: Zhi-feng
authors: ZF
authors: Zhang
authors: a Department of Applied Chemistry and Pharmaceutics , Beijing Institute of Technology , Beijing 100081 , China.
authors: Ning-ning
authors: NN
authors: Liu
authors: b Department of Chemistry , Capital Normal University , Beijing 100048 , China.
authors: Yu-hong
authors: YH
authors: Xiang
authors: b Department of Chemistry , Capital Normal University , Beijing 100048 , China.
authors: Zhuo-yong
authors: ZY
authors: Zhang
authors: c Rega Institute for Medical Research, KU Leuven , Minderbroedersstraat 10, B-3000 Leuven , Belgium.
authors: Graciela
authors: G
authors: Andrei
authors: c Rega Institute for Medical Research, KU Leuven , Minderbroedersstraat 10, B-3000 Leuven , Belgium.
authors: Robert
authors: R
authors: Snoeck
authors: c Rega Institute for Medical Research, KU Leuven , Minderbroedersstraat 10, B-3000 Leuven , Belgium.
authors: Dominique
authors: D
authors: Schols
authors: a Department of Applied Chemistry and Pharmaceutics , Beijing Institute of Technology , Beijing 100081 , China.
authors: Qing-shan
authors: QS
authors: Zhang
authors: a Department of Applied Chemistry and Pharmaceutics , Beijing Institute of Technology , Beijing 100081 , China.
authors: Qin-pei
authors: QP
authors: Wu
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002644:Chickenpox / Q000188:drug therapy; D061565:Cycloaddition Reaction; D003587:Cytomegalovirus / Q000187:drug effects; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D014645:Herpesvirus 3, Human / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000166:cytology / Q000821:virology; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides; D014230:Triazoles
keywords: Huisgen 1,3-dipolar cycloaddition; antiviral; nucleosides; triazole