title: Geometry Shapes Propagation: Assessing the Presence and Absence of Cortical Symmetries through a Computational Model of Cortical Spreading Depression.
abstract: Cortical spreading depression (CSD), a depolarization wave which originates in the visual cortex and travels toward the frontal lobe, has been suggested to be one neural correlate of aura migraine. To the date, little is known about the mechanisms which can trigger or stop aura migraine. Here, to shed some light on this problem and, under the hypothesis that CSD might mediate aura migraine, we aim to study different aspects favoring or disfavoring the propagation of CSD. In particular, by using a computational neuronal model distributed throughout a realistic cortical mesh, we study the role that the geometry has in shaping CSD. Our results are two-fold: first, we found significant differences in the propagation traveling patterns of CSD, both intra and inter-hemispherically, revealing important asymmetries in the propagation profile. Second, we developed methods able to identify brain regions featuring a peculiar behavior during CSD propagation. Our study reveals dynamical aspects of CSD, which, if applied to subject-specific cortical geometry, might shed some light on how to differentiate between healthy subjects and those suffering migraine.
authors: BCAM - Basque Center for Applied Mathematics Bilbao, Spain.
authors: Julia M
authors: JM
authors: Kroos
authors: Computational Neuroimaging Group, Quantitative Biomedicine Unit, Biocruces Health Research Institute, Cruces University Hospital Barakaldo, Spain.
authors: Ibai
authors: I
authors: Diez
authors: Computational Neuroimaging Group, Quantitative Biomedicine Unit, Biocruces Health Research Institute, Cruces University HospitalBarakaldo, Spain; Ikerbasque, The Basque Foundation for ScienceBilbao, Spain; Department of Cell Biology and Histology, University of the Basque CountryLeioa, Spain.
authors: Jesus M
authors: JM
authors: Cortes
authors: BCAM - Basque Center for Applied MathematicsBilbao, Spain; Dipartimento di Fisica, Center of Innovative Technologies for Signal Detection and Processing, Istituto Nazionale di Fisica Nucleare Sezione di Bari, Università di BariBari, Italy.
authors: Sebastiano
authors: S
authors: Stramaglia
authors: BCAM - Basque Center for Applied Mathematics Bilbao, Spain.
authors: Luca
authors: L
authors: Gerardo-Giorda
keywords: computational model; cortical spreading depression; finite elements simulation; magnetic resonance imaging; reaction diffusion; realistic cortical geometry