title: Characteristics of resistin in rheumatoid arthritis angiogenesis.
abstract: Adipokines have been reported to be involved in the regulation of various physiological processes, including the immune response. Rheumatoid arthritis (RA) is an example of a systemic immune disease that causes chronic inflammation of the synovium and bone destruction in the joint. Recent therapeutic strategies based on the understanding of the role of cytokines and cellular mechanisms in RA have improved our understanding of angiogenesis. On the other hand, endogenous endothelial progenitor cells, which are a population isolated from peripheral blood monocytes have recently been identified as a homing target for pro-angiogeneic factor and vessel formation. In this review, we summarize the effects of common adipokines, such as adiponectin, leptin and resistin in RA pathogenesis and discuss other potential mechanisms of relevance for the therapeutic treatment of RA.
authors: Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.|Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
authors: Chen-Ming
authors: CM
authors: Su
authors: Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.|Department of Orthopedic Surgery, China Medical University Beigang Hospital, Yun-Lin County, Taiwan.
authors: Chun-Yin
authors: CY
authors: Huang
authors: Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.|Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.|Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan.
authors: Chih-Hsin
authors: CH
authors: Tang
mesh_terms: D052242:Adiponectin / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000473:pathology; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood; D035683:MicroRNAs / Q000097:blood / Q000378:metabolism; D009389:Neovascularization, Pathologic; D052243:Resistin / Q000097:blood*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D052242:Adiponectin; D020738:Leptin; D035683:MicroRNAs; D052243:Resistin
keywords: adipokine; adiponectin; endothelial progenitor cell; leptin; resistin; rheumatoid arthritis