title: Effect of Erythropoietin and Stem Cells on Traumatic Brain Injury.
abstract: OBJECTIVE
  To investigate the healing effects of erythropoietin (EPO) and stem cells (SCs) in traumatic brain injury (TBI).
  
  
  METHODS
  Twenty-nine Wistar albino rats were used and separated into the following groups: control (C), EPO, SC, and SC+EPO. Group C received a TBI only, with no treatment. In the EPO group, 1000 U/kg EPO was given intraperitoneally at 30 minutes after TBI. In SC group, immediately after formation of TBI, 3 × 10,000 CD34(+) stem cells were injected into the affected area. In the SC+EPO group, half an hour after TBI and the injection of stem cells, 1000 U/kg EPO was injected. Before and after injury, trauma coordination performance was measured by the rotarod and inclined plane tests.
  
  
  RESULTS
  Seven weeks after trauma, rat brains were examined by radiology and histology. Rotarod performance test did not change remarkably, even after the injury. Compared with group C, the SC+EPO group was found to have significant differences in the inclined plane test results.
  
  
  CONCLUSIONS
  Separately given, SCs and EPO have a positive effect on TBI, and our findings suggest that their coadministration is even more powerful.
authors: Department of Physiology, Pamukkale University, Denizli, Turkey. Electronic address: tuncmelekk@hotmail.com.
authors: Melek
authors: M
authors: Tunc Ata
authors: Department of Physiology, Pamukkale University, Denizli, Turkey.
authors: Günfer
authors: G
authors: Turgut
authors: Department of Pathology, Pamukkale University, Denizli, Turkey.
authors: Metin
authors: M
authors: Akbulut
authors: Department of Radiology, Pamukkale University, Denizli, Turkey.
authors: Ali
authors: A
authors: Kocyigit
authors: Department of Obstetrics and Gynecology, Pamukkale University, Denizli, Turkey.
authors: Aysun
authors: A
authors: Karabulut
authors: Department of Biostatistics, Pamukkale University, Denizli, Turkey.
authors: Hande
authors: H
authors: Senol
authors: Department of Physiology, Pamukkale University, Denizli, Turkey.
authors: Sebahat
authors: S
authors: Turgut
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D000070642:Brain Injuries, Traumatic / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D003131:Combined Modality Therapy; D036101:Cord Blood Stem Cell Transplantation; D004195:Disease Models, Animal; D004921:Erythropoietin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008279:Magnetic Resonance Imaging; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D017208:Rats, Wistar; D045442:Rotarod Performance Test; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; D018696:Neuroprotective Agents; D004921:Erythropoietin
keywords: Erythropoietin; Stem cell; Traumatic brain injury