title: Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory.
abstract: The present study examined memory function in Tc1 mice, a transchromosomic model of Down syndrome (DS). Tc1 mice demonstrated an unusual delay-dependent deficit in recognition memory. More specifically, Tc1 mice showed intact immediate (30sec), impaired short-term (10-min) and intact long-term (24-h) memory for objects. A similar pattern was observed for olfactory stimuli, confirming the generality of the pattern across sensory modalities. The specificity of the behavioural deficits in Tc1 mice was confirmed using APP overexpressing mice that showed the opposite pattern of object memory deficits. In contrast to object memory, Tc1 mice showed no deficit in either immediate or long-term memory for object-in-place information. Similarly, Tc1 mice showed no deficit in short-term memory for object-location information. The latter result indicates that Tc1 mice were able to detect and react to spatial novelty at the same delay interval that was sensitive to an object novelty recognition impairment. These results demonstrate (1) that novelty detection per se and (2) the encoding of visuo-spatial information was not disrupted in adult Tc1 mice. The authors conclude that the task specific nature of the short-term recognition memory deficit suggests that the trisomy of genes on human chromosome 21 in Tc1 mice impacts on (perirhinal) cortical systems supporting short-term object and olfactory recognition memory.
authors: School of Psychology, Cardiff University, CF10 3AT, UK.
authors: Jessica H
authors: JH
authors: Hall
authors: Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors: Frances K
authors: FK
authors: Wiseman
authors: Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors: Elizabeth M C
authors: EM
authors: Fisher
authors: Francis Crick Institute, The Ridgeway, Mill Hill, London NW7 1AA, UK; Imperial College, London W12 0NN, UK.
authors: Victor L J
authors: VL
authors: Tybulewicz
authors: School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
authors: John L
authors: JL
authors: Harwood
authors: School of Psychology, Cardiff University, CF10 3AT, UK. Electronic address: Good@cardiff.ac.uk.
authors: Mark A
authors: MA
authors: Good
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000235:genetics / Q000523:psychology*; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D008297:Male; D008569:Memory Disorders / Q000235:genetics / Q000523:psychology*; D057567:Memory, Long-Term / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology*; D051379:Mice; D021641:Recognition, Psychology / Q000502:physiology*; D013037:Spatial Behavior / Q000502:physiology
keywords: Memory; Perirhinal; Recognition; Spatial; Tc1; Trisomy-21