title: Cerebrospinal fluid oxytocin correlated with peripheral ALT and AST in Chinese female subjects.
abstract: OBJECTIVE
  Oxytocin (OT) is primarily synthesized in the paraventricular nucleus of the hypothalamus and supraoptic nucleus of the hypothalamus in the central nervous system and exhibits a wide spectrum of central and peripheral activities. OT is involved in lipid metabolism and glucose homeostasis and plays a protective role against liver damage.
  
  
  METHODS
  In this study, we investigated whether CSF OT levels correlates with peripheral glucose, lipid profiles, and/or liver enzymes in Chinese subjects. Sixty-nine subjects (n=36 males; n=33 females) who were recruited from Beijing Jishuitan Hospital participated in the study. Their levels of CSF OT and peripheral parameters were assayed by radioimmunoassay and continuous monitoring assay, respectively.
  
  
  RESULTS
  There was no significant difference in CSF OT levels between males (53.09±6.88 nmol/mL) and females (52.34±6.87 nmol/mL), and no correlation found between CSF OT levels and peripheral glucose and lipid profiles. Significant negative correlation was observed between CSF OT levels and peripheral ALT and AST concentration in females but not in males.
  
  
  CONCLUSIONS
  Our results support the physiological role of neuropeptides acting on brain sites to regulate liver enzymes, and shed new light on the brain-liver interaction.
authors: Department of Breast Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
authors: Yang
authors: Y
authors: Yu
authors: Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot, China.
authors: Yimin
authors: Y
authors: Kang
authors: Ningbo Fourth Hospital, Xiangshan, China.
authors: Guoshi
authors: G
authors: Qiu
authors: Wenzhou Medical University, Wenzhou, China.
authors: Hong
authors: H
authors: Lin
authors: The Affiliated Wenling Hospital of Wenzhou Medial University, Wenling, China.
authors: Jinzhong
authors: J
authors: Xu
authors: Wenzhou Medical University, Wenzhou, China.
authors: Xiaofang
authors: X
authors: Wang
authors: Ningbo Fourth Hospital, Xiangshan, China.
authors: Longteng
authors: L
authors: Xie
authors: Ningbo Fourth Hospital, Xiangshan, China.
authors: Yongsheng
authors: Y
authors: Jiang
authors: Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot, China.
authors: Baofu
authors: B
authors: Jia
authors: Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot, China.
authors: Pengxiang
authors: P
authors: Wang
authors: Beijing Jishuitan Hospital, Beijing, China.
authors: Geng
authors: G
authors: Wang
authors: Beijing Jishuitan Hospital, Beijing, China.
authors: Qiujun
authors: Q
authors: Li
authors: Beijing Jishuitan Hospital, Beijing, China.
authors: Xiaoyu
authors: X
authors: Yang
authors: Ningbo Fourth Hospital, Xiangshan, China.
authors: Wei
authors: W
authors: Zuo
authors: Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot, China.
authors: Cunbao
authors: C
authors: Li