title: Photoredox-Catalyzed Intramolecular Difluoromethylation of N-Benzylacrylamides Coupled with a Dearomatizing Spirocyclization: Access to CF2H-Containing 2-Azaspiro[4.5]deca-6,9-diene-3,8-diones.
abstract: A visible light-mediated difluoromethylation of N-benzylacrylamides with HCF2SO2Cl as the HCF2 radical precursor is described. The reaction incorporates a tandem cyclization/dearomatization process to afford various difluoromethylated 2-azaspiro[4.5]deca-6,9-diene-3,8-diones bearing adjacent quaternary stereocenters under mild conditions in moderate to excellent yields.
authors: Department of Chemistry, University of Florida , Gainesville, Florida 32611-7200, United States.
authors: Zuxiao
authors: Z
authors: Zhang
authors: Department of Chemistry, University of Florida , Gainesville, Florida 32611-7200, United States.
authors: Xiao-Jun
authors: XJ
authors: Tang
authors: Department of Chemistry, University of Florida , Gainesville, Florida 32611-7200, United States.
authors: William R
authors: WR
authors: Dolbier