title: Radical-Mediated Enzymatic Polymerizations.
abstract: Polymerization reactions are commonly effected by exposing monomer formulations to some initiation stimulus such as elevated temperature, light, or a chemical reactant. Increasingly, these polymerization reactions are mediated by enzymes--catalytic proteins--owing to their reaction efficiency under mild conditions as well as their environmental friendliness. The utilization of enzymes, particularly oxidases and peroxidases, for generating radicals via reduction-oxidation mechanisms is especially common for initiating radical-mediated polymerization reactions, including vinyl chain-growth polymerization, atom transfer radical polymerization, thiol-ene step-growth polymerization, and polymerization via oxidative coupling. While enzyme-mediated polymerization is useful for the production of materials intended for subsequent use, it is especially well-suited for in situ polymerizations, where the polymer is formed in the place where it will be utilized. Such polymerizations are especially useful for biomedical adhesives and for sensing applications.
authors: Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, MI 48109, USA. szavada@umich.edu.
authors: Scott R
authors: SR
authors: Zavada
authors: Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. tsatsa@umich.edu.
authors: Tsatsral
authors: T
authors: Battsengel
authors: Department of Chemical Engineering and Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, MI 48109, USA. tfscott@umich.edu.
authors: Timothy F
authors: TF
authors: Scott
mesh_terms: D055162:Biocatalysis; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000737:chemistry / Q000378:metabolism; D058105:Polymerization; D017382:Reactive Oxygen Species / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D017382:Reactive Oxygen Species; D010544:Peroxidases
keywords: ATRP; enzymes; oxidase; oxidative coupling; peroxidase; polymerization; thiol–ene; vinyl