title: Synthesis, Polymorphism, and Insecticidal Activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate Against Anopheles arabiensis Mosquito.
abstract: Mosquitoes are the major vectors of pathogens and parasites including those causing malaria, the most deadly vector-borne disease. The negative environmental effects of most synthetic compounds combined with widespread development of insecticide resistance encourage an interest in finding and developing alternative products against mosquitoes. In this study, pyrimido[2,1-b]quinazoline derivative DHPM3 has been synthesized by three-step chemical reaction and screened for larvicide, adulticide, and repellent properties against Anopheles arabiensis, one of the dominant vectors of malaria in Africa. The title compound emerged as potential larvicide agent for further research and development, because it exerted 100% mortality, while adulticide activity was considered moderate.
authors: Department of Biotechnology and Food Technology, Faculty of Applied Sciences, Durban University of Technology, Durban, 4001, South Africa.
authors: Katharigatta N
authors: KN
authors: Venugopala
authors: Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra, 440010, India.
authors: Susanta K
authors: SK
authors: Nayak
authors: CREAN-IMBIV (CONICET-UNC), Universidad Nacional de Córdoba, Av. Valparaíso s.n., Córdoba, 5000, Argentina.|FCEFyN, Universidad Nacional de Córdoba, Av. Vélez Sársfield 299, Córdoba, 5000, Argentina.
authors: Raquel M
authors: RM
authors: Gleiser
authors: Instituto de Investigaciones Biológicas y Tecnológicas (IIBYT), CONICET-Universidad Nacional de Córdoba, Av. Vélez Sarsfield 1611, Córdoba, 5016, Argentina.
authors: Mariela E
authors: ME
authors: Sanchez-Borzone
authors: Instituto de Investigaciones Biológicas y Tecnológicas (IIBYT), CONICET-Universidad Nacional de Córdoba, Av. Vélez Sarsfield 1611, Córdoba, 5016, Argentina.
authors: Daniel A
authors: DA
authors: Garcia
authors: Department of Biotechnology and Food Technology, Faculty of Applied Sciences, Durban University of Technology, Durban, 4001, South Africa.
authors: Bharti
authors: B
authors: Odhav
mesh_terms: D000818:Animals; D000852:Anopheles / Q000187:drug effects* / Q000254:growth & development; D015195:Drug Design; D005260:Female; D006860:Hydrogen Bonding; D007302:Insect Repellents; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects* / Q000254:growth & development; D016014:Linear Models; D008297:Male; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D051189:Murinae / Q000469:parasitology; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D052999:Quinazolinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D016019:Survival Analysis; D014961:X-Ray Diffraction
chemical_list: C000615604:DHPM2 compound; C000615605:DHPM3 compound; D007302:Insect Repellents; D007306:Insecticides; D011743:Pyrimidines; D011744:Pyrimidinones; D011799:Quinazolines; D052999:Quinazolinones; C000615603:methyl 4-(4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
keywords: antimosquito properties; crystallography; polymorphism; pyrimido[2,1-b]quinazoline; synthesis