title: Clinicopathological features of primary gastric neuroendocrine neoplasms: A single-center analysis.
abstract: OBJECTIVE
  To assess the clinical characteristics, diagnosis and therapeutic modalities for gastric neuroendocrine neoplasms (GNENs) among the Chinese population in a single institution.
  
  
  METHODS
  A total of 57 patients with histologically confirmed GNENs, who were diagnosed between 1995 and 2015 at the Peking Union Medical College Hospital were retrospectively reviewed. The clinical, imaging and histopathologic characteristics as well as the treatments of GNENs were collected and analyzed.
  
  
  RESULTS
  Patients with GNENs mostly presented with non-specific symptoms. Gastric body was the most common site of involvement. The choice of imaging modality, such as endoscopy and computed tomography depended on the tumor subtype. Chromogranin A (CgA) and synaptophysin were indispensable immunohistochemical markers for diagnosis. Significant inter-group differences in the positivity rate of CD56 were observed among the three grades (G1, G2 and G3). Therapeutic modalities included endoscopic intervention, surgical resection and pharmacotherapy, which were largely guided by the tumor subtype and the presence or absence of distant metastasis or tumor recurrence.
  
  
  CONCLUSIONS
  Routine endoscopic examination is recommended for the early diagnosis of GNENs. Histopathological examination can make the definite diagnosis of GNENs and clarify the nature of gastric polyps. A multidisciplinary approach is important in the management of patients with GNENs.
authors: Department of Gastroenterology, Beijing, 100730, China.
authors: Tian Ming
authors: TM
authors: Xu
authors: Department of Gastroenterology, Beijing, 100730, China.
authors: Chun Sai'er
authors: CS
authors: Wang
authors: Department of Pathology, Peking Union Medical College Hospital, Beijing, 100730, China.
authors: Cong Wei
authors: CW
authors: Jia
authors: Department of Gastroenterology, Beijing, 100730, China.
authors: Jia Ming
authors: JM
authors: Qian
authors: Department of Gastroenterology, Beijing, 100730, China.
authors: Jing Nan
authors: JN
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D053379:Chromogranin A / Q000378:metabolism; D055088:Early Detection of Cancer / Q000379:methods; D019160:Endosonography; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000628:therapy; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D016708:Synaptophysin / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; C506150:CHGA protein, human; D053379:Chromogranin A; C569014:SYP protein, human; D016708:Synaptophysin
keywords: chromogranin A; diagnostic imaging; neuroendocrine tumors; synaptophysin; treatment