title: Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study.
abstract: The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate vascular status of the choroid exists. Choroidal vascularity index (CVI) may potentially be used to assess vascular status of the choroid. We aimed to establish normative database for CVI and identify factors associated with CVI in healthy eyes. In this population-based study on 345 healthy eyes, choroidal enhanced depth imaging optical coherence tomography scans were segmented by modified image binarization technique. Total subfoveal choroidal area (TCA) was segmented into luminal (LA) and stromal (SA) area. CVI was calculated as the proportion of LA to TCA. Linear regression was used to identify ocular and systemic factors associated with CVI and subfoveal choroidal thickness (SFCT). Subfoveal CVI ranged from 60.07 to 71.27% with a mean value of 65.61 ± 2.33%. CVI was less variable than SFCT (coefficient of variation for CVI was 3.55 vs 40.30 for SFCT). Higher CVI was associated with thicker SFCT, but not associated with most physiological variables. CVI was elucidated as a significant determinant of SFCT. While SFCT was affected by many factors, CVI remained unaffected suggesting CVI to be a more robust marker of choroidal diseases.
authors: Singapore Eye Research Institute and Singapore National Eye Center, Singapore.|National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
authors: Rupesh
authors: R
authors: Agrawal
authors: Singapore Eye Research Institute and Singapore National Eye Center, Singapore.|Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
authors: Preeti
authors: P
authors: Gupta
authors: Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
authors: Kara-Anne
authors: KA
authors: Tan
authors: Singapore Eye Research Institute and Singapore National Eye Center, Singapore.|Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.|Duke-NUS Graduate Medical School, Singapore.
authors: Chui Ming Gemmy
authors: CM
authors: Cheung
authors: Singapore Eye Research Institute and Singapore National Eye Center, Singapore.|Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.|Duke-NUS Graduate Medical School, Singapore.
authors: Tien-Yin
authors: TY
authors: Wong
authors: Singapore Eye Research Institute and Singapore National Eye Center, Singapore.|Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.|Duke-NUS Graduate Medical School, Singapore.
authors: Ching-Yu
authors: CY
authors: Cheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002829:Choroid / Q000098:blood supply*; D015862:Choroid Diseases / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged