title: Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.
abstract: Ten alkaloids (1-10), with sophoridine (1) as the most abundant component, were obtained from the whole plants of Oxytropis ochrocephala Bunge. Furthermore, eight new sophoridine derivatives (11-16, 20, 21), with modification on the C-14 position of 1 were synthesized. All compounds (1-16, 20, 21) were evaluated for antiproliferative activity against five human tumor cell lines. Among them, the newly synthesized derivative 20 exhibited the best inhibitory activity against the tested cell lines. Its activity was increased by more than fourfold as compared with parent compound 1.
authors: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States; College of Chemistry and Environment, Guizhou Minzu University, Guiyang 550025, People's Republic of China. Electronic address: tcj1229@163.com.
authors: Cheng-jian
authors: CJ
authors: Tan
authors: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States.
authors: Yu
authors: Y
authors: Zhao
authors: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States.
authors: Masuo
authors: M
authors: Goto
authors: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Kan-Yen
authors: KY
authors: Hsieh
authors: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States.
authors: Xiao-ming
authors: XM
authors: Yang
authors: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States.
authors: Susan L
authors: SL
authors: Morris-Natschke
authors: Department of Medical Biotechnology, Guiyang Medical University, Guiyang 550004, People's Republic of China.
authors: Li-na
authors: LN
authors: Liu
authors: College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China. Electronic address: zhaobaoyu2005@163.com.
authors: Bao-yu
authors: BY
authors: Zhao
authors: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States; Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40447, Taiwan. Electronic address: khlee@unc.edu.
authors: Kuo-Hsiung
authors: KH
authors: Lee
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D033021:Oxytropis / Q000737:chemistry*; D011807:Quinolizines / Q000737:chemistry*; D013329:Structure-Activity Relationship; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D011807:Quinolizines; D000093842:Matrines
keywords: Antiproliferative; Oxytropis ochrocephala; Poisonous plant; Sophoridine derivatives