title: Perfluorocarbon-Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer.
abstract: Hollow Bi2 Se3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With these nanoparticles, a promising concept is demonstrated to enhance radiotherapy by not only using their X-ray-absorbing ability to locally concentrate radiation energy in the tumor, but also employing near-infrared light to trigger burst release of oxygen from the nanoparticles to overcome hypoxia-associated radio-resistance.
authors: Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors: Guosheng
authors: G
authors: Song
authors: Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors: Chao
authors: C
authors: Liang
authors: School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.
authors: Xuan
authors: X
authors: Yi
authors: School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.
authors: Qi
authors: Q
authors: Zhao
authors: Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors: Liang
authors: L
authors: Cheng
authors: School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.
authors: Kai
authors: K
authors: Yang
authors: Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors: Zhuang
authors: Z
authors: Liu
mesh_terms: D000818:Animals; D001729:Bismuth / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage / Q000187:drug effects / Q000528:radiation effects; D005466:Fluorocarbons / Q000737:chemistry*; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D051379:Mice; D046529:Microscopy, Electron, Transmission; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D016566:Organoselenium Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000737:chemistry; D018036:Selenium Compounds; D014184:Transplantation, Homologous
chemical_list: D005466:Fluorocarbons; D016566:Organoselenium Compounds; D018036:Selenium Compounds; D011092:Polyethylene Glycols; C000613026:bismuth selenide; D010100:Oxygen; D001729:Bismuth
keywords: cation exchange; enhanced radiation therapy; hollow structures; overcome tumor hypoxia; oxygen carries