title: Construction of Spirocyclic Oxindoles through Regio- and Stereoselective [3+2] or [3+2]/[4+2] Cascade Reaction of α,β-Unsaturated Imines with 3-Isothiocyanato Oxindole.
abstract: On the basis of asymmetric regioselective [3+2] or [3+2]/[4+2] cascade reaction of 3-isothiocyanato oxindoles with C=C and C=N bonds of α,β-unsaturated methanesulfonamides, diversified S-containing heterocyclic spirooxindole derivatives could be obtained in high yields along with good to excellent diastereo- and enantioselectivities under mild conditions in the presence of cinchona alkaloid-derived organocatalysts.
authors: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road No. 130, Shanghai, 200237, P. R. China.
authors: Dan
authors: D
authors: Du
authors: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road No. 130, Shanghai, 200237, P. R. China.
authors: Qin
authors: Q
authors: Xu
authors: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, P. R. China.
authors: Xiao-Ge
authors: XG
authors: Li
authors: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road No. 130, Shanghai, 200237, P. R. China. mshi@mail.sioc.ac.cn.|State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, P. R. China. mshi@mail.sioc.ac.cn.
authors: Min
authors: M
authors: Shi
keywords: asymmetric synthesis; cascade reaction; diastereoselectivity; organocatalysis; spirooxindole