title: Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma.
abstract: We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signaling pathways and serve as antioxidants. In this review, we will discuss seven common flavonoids that exert different biological effects against HCC via different pathways.
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan; Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu, Taipei 114, Taiwan.
authors: Chen-Yi
authors: CY
authors: Liao
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Ching-Chang
authors: CC
authors: Lee
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Chi-chang
authors: CC
authors: Tsai
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Chao-Wen
authors: CW
authors: Hsueh
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Chih-Chiang
authors: CC
authors: Wang
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: I-Hung
authors: IH
authors: Chen
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Ming-Kai
authors: MK
authors: Tsai
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Mei-Yu
authors: MY
authors: Liu
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: An-Tie
authors: AT
authors: Hsieh
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Kuan-Jen
authors: KJ
authors: Su
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Hau-Ming
authors: HM
authors: Wu
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Shih-Chung
authors: SC
authors: Huang
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Yi-Chen
authors: YC
authors: Wang
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Chien-Yao
authors: CY
authors: Wang
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Shu-Fang
authors: SF
authors: Huang
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Yen-Cheng
authors: YC
authors: Yeh
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Ren-Jy
authors: RJ
authors: Ben
authors: Department of Pathology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Shang-Tao
authors: ST
authors: Chien
authors: Department of General Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Chin-Wen
authors: CW
authors: Hsu
authors: Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors: Wu-Hsien
authors: WH
authors: Kuo
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D005419:Flavonoids