title: [The study of rs1800012 polymorphism of the alphal-chain collagen type 1 gene in Moscow women and children with different level of bone strength].
abstract: The frequency of rs1800012 polymorphism of alpha1-chains of type 1 collagen gene (COL1A1) was studied by real-time PCR in 422 Moscow women and children, including pregnant women (n=96), lactating (n=29) and non-pregnant women (n=28) and preschool children (2-6 years, n=76) and school children (7-16 years, n=193) with different levels of bone strength (BS) as determined by ultrasound densitometry. It was found that the decrease in the value of the BS (Z-score < -1) was observed in 60% of women, 54% of preschool children and 48% of school-aged children. In the surveyed cohort the predominant genotype of rs1800012 polymorphism CO1A1 geneI gene was GG (55.1%), the frequency of the genotype TT--7.6%, of T-allele--26.2%. There were no statistically significant relationships of BS with a particular genotype of rs1800012 polymorphism 1f1COLIAI gene in all examined women. A positive but not statistically significant association of T allele with a risk BS reduction was found in non-pregnant and pregnant women (OR=2.143, p=0.31 and OR=1.227, p=0.55, respectively). For preschool and school-aged children T allele was not associated with the risk of BS reduction. In school-age children a statistically significant inverse association of T allele with the risk of BS reduction was shown (OR=0.621 wth
authors: N M
authors: NM
authors: Shilina
authors: E Yu
authors: EY
authors: Sorokina
authors: T A
authors: TA
authors: Ivanushkina
authors: A I
authors: AI
authors: Safronova
authors: M V
authors: MV
authors: Gmoshinskaya
authors: I Ya
authors: IY
authors: Kon
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D015519:Bone Density / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D024042:Collagen Type I / Q000235:genetics*; D000090602:Collagen Type I, alpha 1 Chain; D003720:Densitometry; D005260:Female; D005838:Genotype; D006801:Humans; D009031:Moscow; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy
chemical_list: D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain