title: Predictive factors for biochemical recurrence in radical prostatectomy patients.
abstract: BACKGROUND
  Radical prostatectomy (RP) is considered the best treatment for the management of localized prostate cancer in patients with life expectancy over 10 years. However, a complete recovery is not guaranteed for all patients who received/underwent RP treatment. Biochemical recurrence is frequently observed during the post-operative follow-up period. The main objective in this study is to evaluate the predictive factors of biochemical recurrence in localized prostate cancer patients who underwent RP surgery.
  
  
  METHODS
  The study included 352 patients with prostate cancer treated by RP at a single institution between February 2004 and June 2014. Detailed pathological and follow-up data of all patients were obtained and analyzed to determine the results.
  
  
  RESULTS
  Mean follow-up duration was 39.7 months. 83 patients (23%) experienced biochemical recurrence (BCR) during the follow-up period. Mean BCR duration range was 6.56 (1-41) months. In multivariate logistic regression analysis, Gleason score (GS), PSA and extra-capsular tumour spread (ECS) variables were found to be statistically significant as BCR predictive factors.
  
  
  CONCLUSIONS
  According to our study results, it is thought that PSA, GS and ECS can all be used for guidance in choosing a treatment modality for post-RP biochemical recurrence and metastatic disease as predictive factors. However, there is no consensus in this matter and it is still debated.
authors: Tepecik Teaching and Research Hospital, Department of Urology, Izmir, Turkey.
authors: Hakan
authors: H
authors: Turk
authors: Tepecik Teaching and Research Hospital, Department of Urology, Izmir, Turkey.
authors: Orcun
authors: O
authors: Celik
authors: Katip Celebi University Medical School Hospital, Izmir, Turkey.
authors: Sitki
authors: S
authors: Un
authors: Tepecik Teaching and Research Hospital, Department of Urology, Izmir, Turkey.
authors: Mehmet
authors: M
authors: Yoldas
authors: Tepecik Teaching and Research Hospital, Department of Urology, Izmir, Turkey.
authors: Cemal Selcuk
authors: CS
authors: İsoglu
authors: Tepecik Teaching and Research Hospital, Department of Urology, Izmir, Turkey.
authors: Mustafa
authors: M
authors: Karabicak
authors: Tepecik Teaching and Research Hospital, Department of Urology, Izmir, Turkey.
authors: Batuhan
authors: B
authors: Ergani
authors: Tepecik Teaching and Research Hospital, Department of Urology, Izmir, Turkey.
authors: Gokhan
authors: G
authors: Koc
authors: Tepecik Teaching and Research Hospital, Department of Urology, Izmir, Turkey.
authors: Ferruh
authors: F
authors: Zorlu
authors: Tepecik Teaching and Research Hospital, Department of Urology, Izmir, Turkey.
authors: Yusuf Ozlem
authors: YO
authors: Ilbey
keywords: Gleason score; prostate cancer; radical prostatectomy; recurrence