title: [Is endometriosis a precancerous lesion? Perspectives and clinical implications].
abstract: Epidemiological studies have shown a relationship between endometriosis and clear cell/endometrioid ovarian cancers (named "Endometriosis Associated Ovarian Cancer" or EAOC). The recent discovery of signaling pathways (especially the SWI/SNF and PI3K/AKT/mTOR pathways) that linked endometriosis and EAOC could lead to the development of specific biomarkers as ARID1A to screen benign to premalignant endometriosis and to new targeted treatment. Moreover, the better understanding of the pathogenesis of the epithelial ovarian cancer arising from the Fallopian tube could allow new early prevention strategies that will be described in this review.
authors: Département de Gynécologie, Hôpital Femme Mère Enfants, HCL, CHU Lyon Est, 59, boulevard Pinel, 69677 Bron, France; Université Claude Bernard Lyon 1, EMR 3738, 69000 Lyon, France. Electronic address: chenegautier@yahoo.fr.
authors: G
authors: G
authors: Chene
authors: Département de Gynécologie, Hôpital Femme Mère Enfants, HCL, CHU Lyon Est, 59, boulevard Pinel, 69677 Bron, France.
authors: J
authors: J
authors: Caloone
authors: Département de Gynécologie, Hôpital Femme Mère Enfants, HCL, CHU Lyon Est, 59, boulevard Pinel, 69677 Bron, France.
authors: S
authors: S
authors: Moret
authors: Département de Gynécologie, Hôpital Femme Mère Enfants, HCL, CHU Lyon Est, 59, boulevard Pinel, 69677 Bron, France.
authors: K
authors: K
authors: Le Bail-Carval
authors: Département de Gynécologie, Hôpital Femme Mère Enfants, HCL, CHU Lyon Est, 59, boulevard Pinel, 69677 Bron, France.
authors: P
authors: P
authors: Chabert
authors: Département de Gynécologie, Hôpital Femme Mère Enfants, HCL, CHU Lyon Est, 59, boulevard Pinel, 69677 Bron, France.
authors: E
authors: E
authors: Beaufils
authors: Département de Gynécologie, Hôpital Femme Mère Enfants, HCL, CHU Lyon Est, 59, boulevard Pinel, 69677 Bron, France.
authors: G
authors: G
authors: Mellier
authors: Département de Gynécologie, Hôpital Femme Mère Enfants, HCL, CHU Lyon Est, 59, boulevard Pinel, 69677 Bron, France.
authors: G
authors: G
authors: Lamblin
mesh_terms: D018262:Adenocarcinoma, Clear Cell; D015415:Biomarkers; D018269:Carcinoma, Endometrioid; D004268:DNA-Binding Proteins; D004715:Endometriosis / Q000453:epidemiology / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D009367:Neoplasm Staging; D009687:Nuclear Proteins; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D011230:Precancerous Conditions; D015398:Signal Transduction; D014157:Transcription Factors
chemical_list: C112476:ARID1A protein, human; D015415:Biomarkers; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors
keywords: ARID1A; Cancer ovarien endométrioïde; Cancer ovarien à cellules claires; Clear cell ovarian carcinoma; Endometrioid ovarian carcinoma; Endometriosis; Endométriose; Fallopian tube; Trompe de Fallope