title: Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives.
abstract: A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA, compound 42 shows the most promising anticancer activity (IC50 1.88 ± 0.20 and 1.37 ± 0.18 µM for MCF-7 and MDA-MB-231, respectively) and merits further exploration as a new anticancer agent.
authors: Marine College, Shandong University,Weihai 264209, China. lychemlh@163.com.|Zhong Yuan Academy of Biological Medicine, Liaocheng People's Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, Liaocheng 252000, China. lychemlh@163.com.
authors: Yang
authors: Y
authors: Li
authors: Marine College, Shandong University,Weihai 264209, China. fenglingjpf@163.com.
authors: Ling
authors: L
authors: Feng
authors: Marine College, Shandong University,Weihai 264209, China. zhifangdl@163.com.
authors: Zhi-Fang
authors: ZF
authors: Song
authors: Marine College, Shandong University,Weihai 264209, China. lihaibei@sdu.edu.cn.
authors: Hai-Bei
authors: HB
authors: Li
authors: Marine College, Shandong University,Weihai 264209, China. huaiqy01@163.com.
authors: Qi-Yong
authors: QY
authors: Huai
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin; D006034:Glycyrrhetinic Acid
keywords: MCF-7; MDA-MB-231; anticancer; derivatives; glycyrrhetinic acid (GA)