title: Domain General Sequence Operations Contribute to Pre-SMA Involvement in Visuo-spatial Processing.
abstract: This study used 3T MRI to elucidate the functional role of supplementary motor area (SMA) in relation to visuo-spatial processing. A localizer task contrasting sequential number subtraction and repetitive button pressing was used to functionally delineate non-motor sequence processing in pre-SMA, and activity in SMA-proper associated with motor sequencing. Patterns of BOLD responses in these regions were then contrasted to those from two tasks of visuo-spatial processing. In one task participants performed Mental Rotation (MR) in which recognition memory judgments were made to previously memorized 2D novel patterns across image-plane rotations. The other task involved abstract grid navigation (GN) in which observers computed a series of imagined location shifts in response to directional (arrow) cues around a mental grid. The results showed overlapping activation in pre-SMA for sequential subtraction and both visuo-spatial tasks. These results suggest that visuo-spatial processing is supported by non-motor sequence operations that involve pre-SMA. More broadly, these data further highlight the functional heterogeneity of pre-SMA, and show that its role extends to processes beyond the planning and online control of movement.
authors: Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University Gwynedd, UK.
authors: E Charles
authors: EC
authors: Leek
authors: Neuroimaging Centre, University Medical Centre Mainz, Germany.
authors: Kenneth S L
authors: KS
authors: Yuen
authors: Department of Psychology, Swansea University Swansea, UK.
authors: Stephen J
authors: SJ
authors: Johnston
keywords: domain general processing; mental rotation; sequence processing; supplementary motor area; visuo-spatial transformation