title: Dramatic Response of a Large, 10 Cm Hepatocellular Carcinoma to Monotherapy with Yttrium-90 Based Selective Internal Radiation Therapy.
abstract: Hepatocellular carcinoma (HCC) is predominantly diagnosed in advanced stages and not amenable to surgical resection and transplantation. Systemic therapies have had a limited efficacy in treating HCC. Although HCC is a radiosensitive tumor, treatments with external-beam radiation are limited by radiosensitivity of normal liver tissue and surrounding organs-at-risk, i.e. bowel, stomach, and kidney. Several large retrospective series have demonstrated a modest effect of selective internal radiation therapy (SIRT) with Yttrium-90 ((90)Y) microspheres in unresectable HCC, both in terms of tumor response and survival. The authors present a patient with an extremely large, multifocal, unresectable HCC who achieved a dramatic response with SIRT treatment.
authors: Radiation Oncology, University of Maryland Medical Center.
authors: Tejan
authors: T
authors: Diwanji
authors: College of Medicine, Howard University.
authors: Tuo
authors: T
authors: Dong
authors: Interventional Radiology, University of Maryland Medical Center.
authors: Fred
authors: F
authors: Moeslein
authors: Radiation Oncology, University of Maryland Medical Center.
authors: Michael
authors: M
authors: Chuong
keywords: hepatocellular carcinoma; radioactive embolization; sirt; tumor embolization