title: Identification of β-glucosidase 1 as a biomarker and its high expression in hepatocellular carcinoma is associated with resistance to chemotherapy drugs.
abstract: OBJECTIVE
  Long-term prognosis of hepatocellular carcinoma (HCC) patients is challenging, and novel biomarkers are needed to predict patient risk and serve as potential therapeutic target.
  
  
  RESULTS
  We found β-glucosidase 1 is significantly overexpressed and activated in primary HCC tissue and multiple HCC cell lines. β-Glucosidase 1 expression is associated with predicting prognosis of HCC patients under chemotherapy. Silencing β-glucosidase 1 inhibits growth and survival of HCC cells, with preferential inhibitory effects on high β-glucosidase 1-expressing cells. Combination of chemo drug with β-glucosidase 1 inhibitor sensitized HCC cells to chemotherapy.
  
  
  CONCLUSIONS
  Our data support β-glucosidase 1 as a HCC biomarker due to its prognosis significance.
authors: a Department of General Surgery , Wuxi People's Hospital , Wuxi , Jiangsu Province , PR China and.
authors: Ye
authors: Y
authors: Zhang
authors: b Nanjing Medical University , Nanjing , Jiangsu Province , PR China.
authors: Kuiyu
authors: K
authors: Zhu
authors: b Nanjing Medical University , Nanjing , Jiangsu Province , PR China.
authors: Xiaofei
authors: X
authors: Miao
authors: b Nanjing Medical University , Nanjing , Jiangsu Province , PR China.
authors: Xingqian
authors: X
authors: Hu
authors: a Department of General Surgery , Wuxi People's Hospital , Wuxi , Jiangsu Province , PR China and.|b Nanjing Medical University , Nanjing , Jiangsu Province , PR China.
authors: Tong
authors: T
authors: Wang
mesh_terms: D017209:Apoptosis / Q000235:genetics; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D049109:Cell Proliferation / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D058990:Molecular Targeted Therapy; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D004791:Enzyme Inhibitors; D001617:beta-Glucosidase
keywords: Biomarker; hepatocellular carcinoma; targeted therapy; β-glucosidase