title: Postprandial thermogenesis and respiratory quotient in response to galactose: comparison with glucose and fructose in healthy young adults.
abstract: Circumstantial evidence suggests that substitution of glucose or sucrose by the low-glycaemic index sugar galactose in the diet may lead to greater thermogenesis and/or fat oxidation. Using ventilated hood indirect calorimetry, we investigated, in twelve overnight-fasted adults, the resting energy expenditure (REE) and respiratory quotient (RQ) for 30 min before and 150 min after ingestion of 500 ml of water containing 60 g of glucose, fructose or galactose in a randomised cross-over design. REE increased similarly with all three sugars, reaching peak values after 50-60 min, but its subsequent fall towards baseline values was faster with galactose and glucose than with fructose (P < 0·001). RQ increased with all three sugars, but to a much greater extent with galactose and fructose than with glucose, particularly after 1 h post-ingestion. When ingested as a sugary drink, postprandial thermogenesis and utilisation of fat after galactose are not higher than after glucose or fructose.
authors: Department of Medicine , Division of Physiology , University of Fribourg , CH 1700 Fribourg , Switzerland.
authors: Nathalie
authors: N
authors: Charrière
authors: Department of Medicine , Division of Physiology , University of Fribourg , CH 1700 Fribourg , Switzerland.
authors: Jean-Pierre
authors: JP
authors: Montani
authors: Department of Medicine , Division of Physiology , University of Fribourg , CH 1700 Fribourg , Switzerland.
authors: Abdul G
authors: AG
authors: Dulloo
keywords: Energy expenditure; Fructose; Galactose; REE, resting energy expenditure; RQ, respiratory quotient; Respiratory quotient; Sugars; Thermogenesis