title: Spinal metastasectomy of renal cell carcinoma: A 16-year single center experience with a minimum 3-year follow-up.
abstract: OBJECTIVE
  Metastasectomy of spinal lesions from renal cell carcinoma (RCC) is a promising strategy. However, its clinical outcome after spinal metastasectomy is unknown owing to the difficulty of curative surgical resection. This is the first study to examine the survival rates of patients who underwent metastasectomy of solitary spinal metastases from RCC.
  
  
  METHODS
  A retrospective cohort study of 36 consecutive patients with RCC who underwent nephrectomy and complete removal of solitary spinal lesions between 1995 and 2010 at our institution. Cancer-specific survival (CSS) time from the spinal metastasectomy to death or last follow-up was the main endpoint. Potential factors associated with survival were evaluated with Kaplan-Meier analysis and the long-rank test.
  
  
  RESULTS
  For all patients, the estimated median CSS time was 130 months. The 3, 5, and 10-year CSS rates were 77.8%, 69.1%, and 58.0%, respectively, for all patients, and 72.7%, 54.5%, and 27.3%, respectively, for patients with lung metastases at the time of surgery. Only the presence of liver metastases was significantly associated with short-term survival after spinal metastasectomy.
  
  
  CONCLUSIONS
  Liver metastases were associated with short-term survival, although lung metastases were not. For selected patients, curative resection of solitary spinal metastases can potentially prolong survival. J. Surg. Oncol. 2016;113:587-592. © 2016 Wiley Periodicals, Inc.
authors: Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors: Satoshi
authors: S
authors: Kato
authors: Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors: Hideki
authors: H
authors: Murakami
authors: Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors: Satoru
authors: S
authors: Demura
authors: Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors: Koshi
authors: K
authors: Nambu
authors: Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors: Yoshiyasu
authors: Y
authors: Fujimaki
authors: Katsuhito
authors: K
authors: Yoshioka
authors: Department of Orthopaedic Surgery, Kanazawa Medical University, Ishikawa, Japan.
authors: Norio
authors: N
authors: Kawahara
authors: Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors: Katsuro
authors: K
authors: Tomita
authors: Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors: Hiroyuki
authors: H
authors: Tsuchiya
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008159:Lumbar Vertebrae; D008297:Male; D059146:Metastasectomy; D008875:Middle Aged; D009392:Nephrectomy; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D015996:Survival Rate; D013904:Thoracic Vertebrae
keywords: metastasectomy; renal cell carcinoma; spinal metastases; spondylectomy; survival