title: Cavernous sinus thrombosis secondary to aspergillus granuloma: A case report and review of the literature.
abstract: Cavernous sinus thrombosis is a rare but serious complication of sphenoid aspergillosis. The rarity of this pathology makes its diagnostic very difficult on a clinical, biological and radiological sense. The authors present a case of cavernous sinus thrombosis with ipsilateral internal carotid artery thrombosis secondary to a non-invasive sphenoid aspergillosis in an immunocompetent host, responsible of a cavernous syndrome associated to a Claude Bernard Horner syndrome. One year after surgery, the patient is still asymptomatic without recurrence. Diagnostic modalities are detailed and several management of this pathology are compared. Surgery is essential in a diagnostic and therapeutic sense. There is no evidence of the interest of adjuvant therapies such as antibiotic and anticoagulation. Concerning the antifungal treatment, the attitude towards a non-invasive sphenoid aspergillosis in an immunocompetent host is unclear.
authors: Department of Oto-rhino-laryngology, Head & Neck Surgery, Robert Debré University Hospital, Reims, France. Electronic address: estebanbrenet@gmail.com.
authors: Esteban
authors: E
authors: Brenet
authors: Department of Anatomopathology, Robert Debré University Hospital, Reims, France.
authors: Camille
authors: C
authors: Boulagnon-Rombi
authors: Department of Infectiology, Robert Debré University Hospital, Reims, France.
authors: Yohan
authors: Y
authors: N'guyen
authors: Department of Neurosurgery, Maison Blanche University Hospital, Reims, France. Electronic address: flitre@chu-reims.fr.
authors: Claude-Fabien
authors: CF
authors: Litré
mesh_terms: D000368:Aged; D001228:Aspergillosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001232:Aspergillus fumigatus; D002341:Carotid Artery Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*; D020226:Cavernous Sinus Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*; D002533:Cerebral Angiography; D005547:Foreign Bodies / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D015745:Granuloma, Foreign-Body / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006732:Horner Syndrome / Q000209:etiology*; D006801:Humans; D007121:Immunocompetence; D008279:Magnetic Resonance Imaging; D008297:Male; D015524:Sphenoid Sinusitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery
keywords: Aspergillus fumigatus; Cavernous sinus thrombosis; Internal carotid artery thrombosis; Non-invasive aspergillosis; Sphenoid sinusitis