title: Oncometabolite Tinkers with Genome Folding, Boosting Oncogene Expression.
abstract: A recent article makes a compelling case for a new mechanism by which heterozygous mutations in isocitrate dehydrogenases (IDH1/2)--implicated in cancer--undermine gene regulation. 2-Hydroxyglutarate (2HG) produced by mutant IDH alters the binding of the chromosomal organizer protein CTCF, disrupting the spatial and regulatory organization of the genome.
authors: MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK. Electronic address: liz.ing-simmons@csc.mrc.ac.uk.
authors: Elizabeth
authors: E
authors: Ing-Simmons
authors: MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK. Electronic address: matthias.merkenschlager@csc.mrc.ac.uk.
authors: Matthias
authors: M
authors: Merkenschlager
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000201:enzymology* / Q000235:genetics*; D006801:Humans; D038101:Insulator Elements / Q000235:genetics*; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics*
chemical_list: D007521:Isocitrate Dehydrogenase