title: Stem and Progenitor Cell-Based Therapy of the Central Nervous System: Hopes, Hype, and Wishful Thinking.
abstract: A variety of neurological disorders are attractive targets for stem and progenitor cell-based therapy. Yet many conditions are not, whether by virtue of an inhospitable disease environment, poorly understood pathophysiology, or poor alignment of donor cell capabilities with patient needs. Moreover, some disorders may be medically feasible targets but are not practicable, in light of already available treatments, poor risk-benefit and cost-benefit profiles, or resource limitations. This Perspective seeks to define those neurological conditions most appropriate for cell replacement therapy by considering its potential efficacy and clinical feasibility in those disorders, as well as potential impediments to its application.
authors: Center for Translational Neuromedicine and the Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Basic and Translational Neuroscience, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen 2200, Denmark. Electronic address: steven_goldman@urmc.rochester.edu.
authors: Steven A
authors: SA
authors: Goldman
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D002490:Central Nervous System / Q000473:pathology*; D002493:Central Nervous System Diseases / Q000628:therapy*; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009410:Nerve Degeneration / Q000473:pathology / Q000628:therapy; D010641:Phenotype; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*
keywords: astrocyte; cell therapy; glial progenitor cell; myelin disease; neural stem cell; neurodegenerative disease; neurological therapeutics; oligodendrocyte progenitor cell