title: Acoustic Characteristics of Voice Before and After Endoscopic Partial Laryngectomy in Early Glottic Cancer.
abstract: OBJECTIVE
  To evaluate the voice changes after narrow-margin endoscopic partial laryngectomy in subjects with T1N0M0 glottic cancer.
  
  
  METHODS
  Uncontrolled retrospective comparison of preoperative and postoperative mean phonation time; fundamental frequency, jitter, shimmer, and noise-to-harmonic ratio; and voice-related quality of life (V-RQOL) survey scores.
  
  
  METHODS
  Seventeen adults diagnosed with T1N0M0 glottic cancer who underwent narrow-margin endoscopic partial laryngectomy were included. All subjects had preoperative and postoperative acoustic evaluation and V-RQOL scores. Subjects were separated into three groups based on age and depth of resection. Group A (mean age, 52 years) consisted of seven subjects who underwent superficial resection (superficial layer of lamina propria) and were younger than 60 years. Group B (mean age, 76 years) consisted of six subjects who were older than 60 years and underwent superficial resection (superficial layer of lamina propria). The four subjects in group C were older than 60 years and underwent deep resection (into the vocal ligament and/or into the thyroarytenoid muscle).
  
  
  RESULTS
  There was a statistically significant improvement in V-RQOL in group A. The acoustic measures did not change after surgery (no P<0.05).
  
  
  CONCLUSIONS
  For early-stage cancer, patients younger than 60 years and superficial resection of cancer are predictive for better voice.
authors: Department of Otolaryngology, Mahidol University, Bangkok, Thailand.
authors: Chanticha
authors: C
authors: Chotigavanich
authors: Department of Otolaryngology, Brigham and Women's Hospital, Boston, Massachusetts.
authors: Jayme R
authors: JR
authors: Dowdall
authors: Division of Laryngology, Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts. Electronic address: ramon_franco@meei.harvard.edu.
authors: Ramon A
authors: RA
authors: Franco
mesh_terms: D000162:Acoustics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005931:Glottis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007825:Laryngectomy / Q000009:adverse effects / Q000379:methods*; D007828:Laryngoscopy / Q000009:adverse effects; D008297:Male; D000072662:Margins of Excision; D008875:Middle Aged; D009367:Neoplasm Staging; D010699:Phonation; D011788:Quality of Life; D020127:Recovery of Function; D012189:Retrospective Studies; D013061:Speech Acoustics; D013068:Speech Production Measurement; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014832:Voice Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D014833:Voice Quality
keywords: Acoustic; Early glottic cancer; Endoscopic; Glottis; Laryngeal cancer; Partial laryngectomy; Transoral; Voice outcomes