title: A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations.
abstract: Dietary intake and higher serum concentrations of lycopene have been associated with lower incidence of prostate cancer and other chronic diseases. Identifying determinants of serum lycopene concentrations may thus have important public health implications. Prior studies have suggested that serum lycopene concentrations are under partial genetic control. The goal of this research was to identify genetic predictors of serum lycopene concentrations using the genome-wide association study (GWAS) approach among a sample of 441 Old Order Amish adults that consumed a controlled diet. Linear regression models were utilized to evaluate associations between genetic variants and serum concentrations of lycopene. Variant rs7680948 on chromosome 4, located in the intron region of the SETD7 gene, was significantly associated with serum lycopene concentrations (p = 3.41 × 10(-9)). Our findings also provided nominal support for the association previously noted between SCARB1 and serum lycopene concentrations, although with a different SNP (rs11057841) in the region. This study identified a novel locus associated with serum lycopene concentrations and our results raise a number of intriguing possibilities regarding the nature of the relationship between SETD7 and lycopene, both of which have been independently associated with prostate cancer. Further investigation into this relationship might help provide greater mechanistic understanding of these associations.
authors: Department of Family & Community Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. cdadamo@som.umaryland.edu.
authors: Christopher R
authors: CR
authors: D'Adamo
authors: The Commonwealth Medical College, Scranton, PA 18509, USA. adurso@tcmc.edu.
authors: Antonietta
authors: A
authors: D'Urso
authors: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. kryan@medicine.umaryland.edu.
authors: Kathleen A
authors: KA
authors: Ryan
authors: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. lyerges@medicine.umaryland.edu.
authors: Laura M
authors: LM
authors: Yerges-Armstrong
authors: Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. rdsemba@jhmi.edu.
authors: Richard D
authors: RD
authors: Semba
authors: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. nsteinle@medicine.umaryland.edu.
authors: Nanette I
authors: NI
authors: Steinle
authors: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. bmitchel@medicine.umaryland.edu.
authors: Braxton D
authors: BD
authors: Mitchell
authors: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. ashuldin@medicine.umaryland.edu.
authors: Alan R
authors: AR
authors: Shuldiner
authors: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. pmcardle@medicine.umaryland.edu.
authors: Patrick F
authors: PF
authors: McArdle
mesh_terms: D000328:Adult; D061365:Amish; D000975:Antioxidants / Q000378:metabolism*; D002338:Carotenoids / Q000097:blood*; D004032:Diet; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D007438:Introns; D000077276:Lycopene; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000097:blood / Q000235:genetics*
chemical_list: D000975:Antioxidants; D002338:Carotenoids; D011495:Histone-Lysine N-Methyltransferase; C540312:SETD7 protein, human; D000077276:Lycopene
keywords: Old Order Amish; SCARB1; SETD7; carotenoids; genome-wide association study (GWAS); lycopene; prostate cancer