title: Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression in two districts of southeast China.
abstract: Plastic production releases phthalate esters (PAEs), which can alter the expression of metallothioneins (MTs), fatty acid transport protein 1 (FATP1) and heart fatty acid binding protein (HFABP). A total of 187 mother-infant pairs were recruited, 127 from Chenghai (high exposed group) and 60 from Haojiang (low exposed group), to investigate the association between neonatal PAE exposure and mRNA expression of placental MTs, FATP1 and HFABP. Umbilical cord blood and placenta samples were collected for measuring five PAE concentrations and detecting mRNA levels of MTs, FATP1 and HFABP. Butylbenzyl phthalate (BBP), di(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP) were significantly higher in the high exposed group compared to the low exposed group. FATP1 and HFABP mRNA in the high exposed group were higher than that in the low exposed group while MT-1A was contrary. Both dimethyl phthalate (DMP) and DEHP were correlated with higher MT and MT-2A expression, while diethyl phthalate (DEP) was also positively correlated with MT-1A and FATP1 expression in female infants. DEHP exposure was negatively correlated with birth weight and gestational age in male infants. These results show that neonatal PAE exposure alters the mRNA expression of placental MTs and FATP1, which are related to fetal growth and development.
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, 22 Xinling Rd., Shantou, 515041, Guangdong, China.|The Second Affiliated Hospital of Shantou University Medical College, 69 Xiabei Rd., Shantou, 515041, Guangdong, China.
authors: Bin
authors: B
authors: Li
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, 22 Xinling Rd., Shantou, 515041, Guangdong, China.|Department of Cell Biology and Genetics, Shantou University Medical College, 22 Xinling Rd., Shantou, 515041, Guangdong, China.
authors: Xijin
authors: X
authors: Xu
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, 22 Xinling Rd., Shantou, 515041, Guangdong, China.
authors: Yueqin
authors: Y
authors: Zhu
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, 22 Xinling Rd., Shantou, 515041, Guangdong, China.
authors: Junjun
authors: J
authors: Cao
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, 22 Xinling Rd., Shantou, 515041, Guangdong, China.
authors: Yuling
authors: Y
authors: Zhang
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, 22 Xinling Rd., Shantou, 515041, Guangdong, China.
authors: Xia
authors: X
authors: Huo
mesh_terms: D000328:Adult; D002681:China; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D050612:Fatty Acid Transport Proteins / Q000096:biosynthesis*; D050556:Fatty Acid-Binding Proteins / Q000096:biosynthesis*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D008668:Metallothionein / Q000096:biosynthesis*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis*
chemical_list: D050612:Fatty Acid Transport Proteins; D050556:Fatty Acid-Binding Proteins; D011257:Pregnancy Proteins; D012333:RNA, Messenger; C493568:SLC27A1 protein, human; D008668:Metallothionein; D004051:Diethylhexyl Phthalate