title: Dopamine reward prediction-error signalling: a two-component response.
abstract: Environmental stimuli and objects, including rewards, are often processed sequentially in the brain. Recent work suggests that the phasic dopamine reward prediction-error response follows a similar sequential pattern. An initial brief, unselective and highly sensitive increase in activity unspecifically detects a wide range of environmental stimuli, then quickly evolves into the main response component, which reflects subjective reward value and utility. This temporal evolution allows the dopamine reward prediction-error signal to optimally combine speed and accuracy.
authors: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
authors: Wolfram
authors: W
authors: Schultz
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D012201:Reward; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D004298:Dopamine