title: Bloodstream infections in pediatric patients at Cancer Institute, Chennai.
abstract: BACKGROUND
  There is paucity of data on the epidemiology of bloodstream infections in pediatric cancer patients from India. Rationale use of antibiotics in febrile neutropenia is important for reducing morbidity and preventing the emergence of drug resistant bacteria.
  
  
  OBJECTIVE
  The study was conducted to look at the prevalence of bloodstream bacterial infection and the antibiotic resistance profile at Cancer Institute, Chennai.
  
  
  METHODS
  This was a retrospective study.
  
  
  METHODS
  Data on all blood cultures taken from pediatric cancer patients treated at Cancer Institute, Chennai, during the year 2013 were analyzed. The microbiological profile and sensitivity pattern were analyzed.
  
  
  RESULTS
  A total of 1045 blood culture samples were taken, and there were 82/1045 (7.5%) positive blood cultures. Gram-negative organisms accounted for 50/82 (61%) of all positive cultures. Klebsiella pneumoniae (32%) was the most common Gram-negative isolate, and Staphylococcus aureus (93.5%) was the most common Gram-positive. There was high resistance to aminoglycosides and beta-lactam/beta-lactamase inhibitor antibodies.
  
  
  CONCLUSIONS
  Gram-negative organisms are the predominant bacteria isolated. There is high resistance to first-line combination antibiotics used as empiric therapy for treatment of febrile neutropenia.
authors: Department of Medical Oncology, Cancer Institute, Adyar, Chennai, Tamil Nadu, India.
authors: V
authors: V
authors: Radhakrishnan
authors: V
authors: V
authors: Vijaykumar
authors: P
authors: P
authors: Ganesan
authors: R
authors: R
authors: Rajendranath
authors: G
authors: G
authors: Trivadi
authors: S
authors: S
authors: Tenali
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology; D002173:Cancer Care Facilities; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D064147:Febrile Neutropenia / Q000150:complications*; D016905:Gram-Negative Bacterial Infections / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D016908:Gram-Positive Bacterial Infections / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007194:India; D007223:Infant; D007231:Infant, Newborn; D009369:Neoplasms / Q000150:complications / Q000628:therapy*; D015995:Prevalence; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents