title: A Comprehensive Meta-analysis of Case-Control Association Studies to Evaluate Polymorphisms Associated with the Risk of Differentiated Thyroid Carcinoma.
abstract: Linkage analyses and association studies suggested that inherited genetic variations play a role in the development of differentiated thyroid carcinoma (DTC).
  
  
  
  We combined the results from a genome-wide association study (GWAS) performed by our group and from published studies on DTC. With a first approach, we evaluated whether a SNP published as associated with the risk of DTC could replicate in our GWAS (using FDR as adjustment for multiple comparisons). With the second approach, meta-analyses were performed between literature and GWAS when both sources suggested an association, increasing the statistical power of the analysis.
  
  
  
  rs1799814 (CYP1A1), rs1121980 (FTO), and 3 SNPs within 9q22 (rs965513, rs7048394, and rs894673) replicated the associations described in the literature. In addition, the meta-analyses between literature and GWAS revealed 10 more SNPs within 9q22, six within FTO, two within SOD1, and single variations within HUS1, WDR3, UGT2B7, ALOX12, TICAM1, ATG16L1, HDAC4, PIK3CA, SULF1, IL11RA, VEGFA, and 1p31.3, 2q35, 8p12, and 14q13.
  
  
  
  This analysis confirmed several published risk loci that could be involved in DTC predisposition.
  
  
  
  These findings provide evidence for the role of germline variants in DTC etiology and are consistent with a polygenic model of the disease. Cancer Epidemiol Biomarkers Prev; 25(4); 700-13. ©2016 AACR.
authors: Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Department of Biology, University of Pisa, Pisa, Italy.
authors: Gisella
authors: G
authors: Figlioli
authors: Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
authors: Rossella
authors: R
authors: Elisei
authors: Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
authors: Cristina
authors: C
authors: Romei
authors: Department of Biology, University of Pisa, Pisa, Italy.
authors: Ombretta
authors: O
authors: Melaiu
authors: Department of Biology, University of Pisa, Pisa, Italy.
authors: Monica
authors: M
authors: Cipollini
authors: Blood Centre, Azienda Ospedaliero Universitaria A. Meyer, Firenze, Italy.
authors: Franco
authors: F
authors: Bambi
authors: Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors: Bowang
authors: B
authors: Chen
authors: Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. II Medizinische Klinik, Gastrologie, Onkologie und Palliativmedizin, St.Agnes-Hospital Bocholt, Bocholt, Germany.
authors: Aleksandra
authors: A
authors: Köhler
authors: Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
authors: Alfonso
authors: A
authors: Cristaudo
authors: Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
authors: Kari
authors: K
authors: Hemminki
authors: Department of Biology, University of Pisa, Pisa, Italy.
authors: Federica
authors: F
authors: Gemignani
authors: Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden. stefano.landi@unipi.it a.foersti@dkfz-heidelberg.de.
authors: Asta
authors: A
authors: Försti
authors: Department of Biology, University of Pisa, Pisa, Italy. stefano.landi@unipi.it a.foersti@dkfz-heidelberg.de.
authors: Stefano
authors: S
authors: Landi
mesh_terms: D016022:Case-Control Studies; D002454:Cell Differentiation; D055106:Genome-Wide Association Study; D006801:Humans; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology