title: SARS-CoV and IFN: Too Little, Too Late.
abstract: Dysregulated type I interferon (IFN-I) expression can lead to severe pathology and disease. In this issue of Cell Host & Microbe, Channappanavar et al. (2016) use a SARS-coronavirus animal model to describe how rapid and robust virus replication with delayed IFN-I can lead to lung immunopathology, with fatal outcomes.
authors: Department of Infectious Diseases and Pathobiology, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, 3012 Bern and 3147 Mittelhäusern, Switzerland.
authors: Eveline
authors: E
authors: Kindler
authors: Department of Infectious Diseases and Pathobiology, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, 3012 Bern and 3147 Mittelhäusern, Switzerland. Electronic address: volker.thiel@vetsuisse.unibe.ch.
authors: Volker
authors: V
authors: Thiel
mesh_terms: D000818:Animals; D007370:Interferon Type I; D008168:Lung / Q000821:virology; D045473:Severe acute respiratory syndrome-related coronavirus; D014779:Virus Replication
chemical_list: D007370:Interferon Type I