title: Association between thyroid hormone levels and insulin resistance and body mass index.
abstract: OBJECTIVE
  Previous studies have shown an association between thyroid function and insulin resistance and obesity. We compared insulin resistance and body mass index (BMI) in patients with normal TSH levels (2.5-4.2 µIU/mL), patients diagnosed with subclinical hypothyroidism, and healthy control subjects.
  
  
  METHODS
  The study included 104 subjects and was conducted at the Taksim Education and Research Hospital. The subjects were divided into three groups according to TSH levels: Group 1 (high-normal), TSH levels were 2.5-4.2 µIU/mL (n=33); Group 2 (subclinical hypothyroidism), TSH levels were 4.2-10 µIU/mL (n=42); and Group 3 (healthy control), TSH levels were 0.27-2.5 µIU/mL (n=29). The fT3 and fT4 levels were within normal limits in all groups. Insulin resistance and BMI were compared among groups. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to estimate insulin resistance.
  
  
  RESULTS
  HOMA-IR and BMI were not significantly different among groups (p>0.05). A significant positive correlation was found between BMI and HOMA-IR in the high-normal TSH (p>0.059) and subclinical hypothyroidism (p>0.05) groups.
  
  
  CONCLUSIONS
  HOMA-IR and BMI are important for the assessment of diabetes and cardiovascular diseases. We found no significant difference in HOMA-IR and BMI values among the three TSH reference range groups.
authors: Neval Aksoy, Gaziosmanpasa Taksim Education and Research Hospital, Department of Biochemistry, Elazig-Turkey.
authors: Neval
authors: N
authors: Aksoy
authors: Mustafa Taner Yeler, Gaziosmanpasa Taksim Education and Research Hospital, Department of Biochemistry, Elazig-Turkey.
authors: Mustafa Taner
authors: MT
authors: Yeler
authors: Nilhan Nurlu Ayan, Gaziosmanpasa Taksim Education and Research Hospital, Department of Biochemistry, Elazig-Turkey.
authors: Nilhan Nurlu
authors: NN
authors: Ayan
authors: Ali Ozkeskin, Gaziosmanpasa Taksim Education and Research Hospital, Department of Internal Medicine, Elazig-Turkey.
authors: Ali
authors: A
authors: Ozkeskin
authors: Zeynep Ozkan, Elazig Education and Research Hospital, Department of General Surgery, Elazig-Turkey.
authors: Zeynep
authors: Z
authors: Ozkan
authors: N.Ozden Serin, Gaziosmanpasa Taksim Education and Research Hospital, Department of Biochemistry, Elazig-Turkey.
authors: N Ozden
authors: NO
authors: Serin
keywords: Body mass index; Insulin resistance; Thyroid stimulating hormone