title: DRESS syndrome associated with type 2 diabetes in a child.
abstract: Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is an uncommon, life-threatening drug reaction. The basic findings are skin rash, multiorgan involvement, and eosinophilia. Most of the aromatic anticonvulsants, such as phenytoin, phenobarbital and carbamazepine can induce DRESS. Herein we report a 14-year-old patient with DRESS syndrome related to carbamazepine use. The patient presented with signs of involvement of the skin, lungs, liver, and microscopic hematuria. Carbamazepine treatment was discontinued; antihistamines and steroids were started. Hyperglycemia, commencing on the first dose of the steroid given, persisted even after the discontinuation of steroids and improvement of other signs. There were no signs of pancreatitis or type 1 diabetes clinically in laboratory tests. Her blood glucose levels were regulated at first with insulin and later with metformin. Within 1 year of follow-up, still regulated with oral antidiabetics, she has been diagnosed with type 2 diabetes. Formerly, long-term sequelae related to "drug rash with eosinophilia and systemic symptoms syndrome" such as hepatic and renal failure, type 1 diabetes mellitus, Grave's disease, autoimmune hemolytic anemia, and lupus have also been reported. However, up to date, no cases with type 2 diabetes have been reported as long-term sequelae. To our knowledge, this is the first case in the literature presenting with type 2 diabetes as long-term sequelae.
authors: Department of Pediatric Allergy, Dr. Behcet Uz Children Disease and Surgery Training and Research Hospital, Izmir, Turkey.
authors: Semiha Bahceci
authors: SB
authors: Erdem
authors: Department of Pediatric Allergy, Dr. Behcet Uz Children Disease and Surgery Training and Research Hospital, Izmir, Turkey.
authors: Hikmet Tekin
authors: HT
authors: Nacaroglu
authors: Department of Pediatric Allergy, Dr. Behcet Uz Children Disease and Surgery Training and Research Hospital, Izmir, Turkey.
authors: Ozlem
authors: O
authors: Bag
authors: Department of Pediatric Allergy, Dr. Behcet Uz Children Disease and Surgery Training and Research Hospital, Izmir, Turkey.
authors: Canan Sule Unsal
authors: CS
authors: Karkiner
authors: Department of Pediatric Endocrinology, Dr. Behcet Uz Children Disease and Surgery Training and Research Hospital, Izmir, Turkey.
authors: Huseyin Anil
authors: HA
authors: Korkmaz
authors: Department of Pediatric Allergy, Dr. Behcet Uz Children Disease and Surgery Training and Research Hospital, Izmir, Turkey.
authors: Demet
authors: D
authors: Can
keywords: DRESS syndrome; carbamazepine; pneumonia; type 2 diabetes