title: Clinical Manifestations and Outcome of Syphilitic Uveitis.
abstract: OBJECTIVE
  To analyze visual outcome, effectiveness of various modes of antibiotic treatment, and prognostic factors in patients with serologically proven syphilitic uveitis.
  
  
  METHODS
  The clinical records of 85 patients (139 eyes) diagnosed with syphilitic uveitis between 1984 and 2013 at tertiary centers in The Netherlands were retrospectively analyzed.
  
  
  RESULTS
  Mean age was 47 years (range, 27-73 years), 82.4% were male. HIV positivity was found in 28 (35.9%) patients; 13 were newly diagnosed. Most patients had pan (45.9%) or posterior (31.8%) uveitis. On average, logMAR visual acuity (VA) improved significantly from 0.55 at the start of syphilis treatment to 0.34 at 1 month and to 0.27 at 6 months follow-up. Most patients (86.7%) reached disease remission. No differences in efficacy between the various treatment regimens were found. A high logMAR VA at the start of syphilis treatment and a treatment delay of more than 12 weeks were prognostic for a high logMAR VA at 6 months follow-up. Chronicity was not related to any form of treatment, HIV status, or Venereal Disease Research Laboratory test outcome.
  
  
  CONCLUSIONS
  In this large cohort of 85 patients with syphilitic uveitis, visual outcomes were favorable in the majority of cases. Visual outcome was dependent on VA at the start of syphilis treatment and treatment delay.
authors: Rotterdam Eye Hospital, Rotterdam, The Netherlands 2Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Jan G
authors: JG
authors: Bollemeijer
authors: Department of Ophthalmology, University Medical Center Groningen, Groningen, The Netherlands 4W. J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands.
authors: Wietse G
authors: WG
authors: Wieringa
authors: Rotterdam Eye Hospital, Rotterdam, The Netherlands.
authors: Tom O A R
authors: TO
authors: Missotten
authors: Department of Ophthalmology, VU University Medical Center, Amsterdam, The Netherlands.
authors: Ina
authors: I
authors: Meenken
authors: Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Ninette H
authors: NH
authors: ten Dam-van Loon
authors: Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands 7Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors: Aniki
authors: A
authors: Rothova
authors: Department of Ophthalmology, University Medical Center Groningen, Groningen, The Netherlands 4W. J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands.
authors: Leonoor I
authors: LI
authors: Los
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015818:Eye Infections, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006679:HIV Seropositivity / Q000175:diagnosis; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000627:therapeutic use; D010402:Penicillin G Procaine / Q000627:therapeutic use; D012189:Retrospective Studies; D013587:Syphilis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D013588:Syphilis Serodiagnosis; D016896:Treatment Outcome; D014605:Uveitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D014792:Visual Acuity
chemical_list: D000900:Anti-Bacterial Agents; D010402:Penicillin G Procaine; D002443:Ceftriaxone; D004318:Doxycycline; D010400:Penicillin G