title: Screening History Among Women with Invasive Cervical Cancer in an Academic Medical Center: Will We Miss Cancers Following Updated Guidelines?
abstract: Updated guidelines for the screening and management of cervical cancer in the United States recommend starting Papanicolaou (Pap) testing at age 21 and screening less frequently with less aggressive management for abnormalities. We sought to examine updated Pap test screening guidelines and how they may affect the detection of invasive cervical cancer, especially among women <30 years of age.
  
  
  
  Patients diagnosed at Brigham and Women's Hospital with invasive cervical cancer between 2002 and 2012 were retrospectively identified. Prior screening history was obtained and patients were divided into two groups based on age <30 years or age ≥30 years. The two groups were then compared with respect to demographics, pathological findings, and time to diagnosis.
  
  
  
  A total of 288 patients with invasive cervical carcinoma were identified. Among these patients, 109 had adequate information on prior screening history. Invasive adenocarcinoma (IAC) was diagnosed in 37 (33.94%) patients, whereas 64 (58.72%) patients were diagnosed with invasive squamous cell carcinoma (ISCC). The remaining eight patients were diagnosed with other types of cancers of the cervix. A total of 13 patients were younger than 30 while 96 patients were 30 or older. The mean time from normal Pap to diagnosis of IAC was 15 months in patients younger than 30 years of age compared to 56 months in patients aged 30 and older (p < 0.001). The mean time from normal Pap to diagnosis of ISCC was 38 months in patients younger than 30 years of age and 82 months in patients aged 30 and older (p = 0.018).
  
  
  
  In this small retrospective study, updated Pap test screening guidelines would not have missed invasive cancer on average among screened women age 30 and older. However, young patients aged 21-29 years may be at increased risk of developing IAC of the cervix between the recommended screening intervals.
authors: 1 Department of Obstetrics and Gynecology, Division of Gynecologic Surgery , Mayo Clinic, Rochester, Minnesota.
authors: Caroline
authors: C
authors: Nitschmann
authors: 2 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Princess Margaret Cancer Center , Toronto, Canada .
authors: Taymaa
authors: T
authors: May
authors: 3 Department of Pathology, Brigham and Women's Hospital , Boston, Massachusetts.
authors: Jelena
authors: J
authors: Mirkovic
authors: 4 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute , Boston, Massachusetts.
authors: Sarah
authors: S
authors: Feldman
mesh_terms: D000046:Academic Medical Centers; D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008403:Mass Screening; D008404:Massachusetts; D008875:Middle Aged; D065006:Papanicolaou Test / Q000592:standards*; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014626:Vaginal Smears / Q000592:standards*