title: Elevated Systemic Neutrophil Count Is Associated with Diabetic Macroalbuminuria among Elderly Chinese.
abstract: Background. This study investigated an association between systemic absolute neutrophil count (ANC) and albuminuria in elderly Chinese people. Methods. A cross-sectional study was conducted on 2265 participants attending a routine medical examination in Minhang District as part of a Platform of Chronic Disease program. Their drug history, waist circumference, height, blood pressure, fasting blood glucose, ANC, and urine albumin levels were recorded. This study conformed to the requirements of the STROBE statement. Results. Of the 2265 subjects, 1254 (55.4%) were diabetic and 641 (28.3%) had albuminuria. The mean ANC of patients with diabetes comorbid with macroalbuminuria was significantly higher than that of both the nondiabetic patients and patients with diabetes with lower levels of albuminuria; the latter 2 groups had statistically similar ANC. ANC significantly and positively correlated with levels of urine albumin. Based on multivariate analysis, with each 10(9)/L increase in ANC, the increase in rates of macroalbuminuria was significant but not in rates of albuminuria positivity. Based on areas under the receiver operating characteristic curve, ANC was the strongest factor predicting macroalbuminuria. Conclusions. Elevated ANC was associated with macroalbuminuria in diabetes, indicating that neutrophil-mediated inflammation may be involved in the exacerbation of albuminuria.
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Min
authors: M
authors: Yang
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Jun
authors: J
authors: Liu
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Jiong
authors: J
authors: Xu
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Tiange
authors: T
authors: Sun
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Li
authors: L
authors: Sheng
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Zaoping
authors: Z
authors: Chen
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Fang
authors: F
authors: Wang
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Xinmei
authors: X
authors: Huang
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Yueyue
authors: Y
authors: Wu
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Jianfeng
authors: J
authors: Mao
authors: Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
authors: Rui
authors: R
authors: Zhang