title: A review on the management of migraine in the Avicenna's Canon of Medicine.
abstract: Migraine is a common type of headache which has a deep history dating back thousands of years. Avicenna (980-1032), a Persian scholar, made a great contribution to neurology including headache and migraine. The aim of this study is to consider Avicenna's description about migraine (Shaghighe in Persian language) including definition, etiology and intervention. Also, his definition and treatment approaches were considered based on current concepts and findings. Although Avicenna believed in humoral theory and divided migraine into two categories, hot and cold, and suggested special treatments for them as well as general considerations, most of his definitions and explained pathologies are supported by current concepts of medicine. He believed that the migraine can result from bone of skull and also intra-parenchymal; or from skull underneath membrane (dura-mater); or reaching substances from the painful side or from outer vein and arteries (extra cranial); or from brain and meninges (pia-mater). Furthermore, current findings show most medicinal plants mentioned by Avicenna for the treatment of migraine can have potentially significant effects such as remedies which stop central and peripheral sensitization [anti-neuroinflammatory agents, decreasing nitric oxide level, cyclooxygenase (COX)-2 inhibitors], as well as serotonergics, neuroprotective agents and analgesics.
authors: Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran. zargarana@sums.ac.ir.|Research Office for the History of Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. zargarana@sums.ac.ir.
authors: Arman
authors: A
authors: Zargaran
authors: Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.|Deportment of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: Afshin
authors: A
authors: Borhani-Haghighi
authors: Department of Phytopharmaceuticals (Traditional Pharmacy), Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: Pouya
authors: P
authors: Faridi
authors: Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: Saeid
authors: S
authors: Daneshamouz
authors: Department of Phytopharmaceuticals (Traditional Pharmacy), Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: Abdolali
authors: A
authors: Mohagheghzadeh
mesh_terms: D019468:Disease Management; D049691:History, Medieval; D006801:Humans; D008512:Medicine in the Arts; D008514:Medicine, Arabic / Q000266:history*; D008881:Migraine Disorders / Q000266:history* / Q000628:therapy; D019071:Persia; D012014:Reference Books, Medical
keywords: Avicenna; History of medicine; Medieval period; Migraine; Persian medicine