title: Isotretinoin treatment reduces acne lesions but not directly lesional acne inflammation.
authors: PEDEGO Research Center, Department of Dermatology, University of Oulu, Oulu, Finland.|Medical Research Center Oulu (MRC Oulu), Oulu University Hospital, Oulu, Finland.
authors: Hanna-Leena
authors: 0000-0001-9471-9689
authors: HL
authors: Kelhälä
authors: Unit for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland.
authors: Nanna
authors: N
authors: Fyhrquist
authors: PEDEGO Research Center, Department of Dermatology, University of Oulu, Oulu, Finland.
authors: Riitta
authors: R
authors: Palatsi
authors: Department of Dermatology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors: Sari
authors: S
authors: Lehtimäki
authors: Medical Research Center Oulu (MRC Oulu), Oulu University Hospital, Oulu, Finland.|Department of Pathology, University of Oulu and Oulu University Hospital, Oulu, Finland.
authors: Juha P
authors: JP
authors: Väyrynen
authors: PEDEGO Research Center, Department of Dermatology, University of Oulu, Oulu, Finland.|Medical Research Center Oulu (MRC Oulu), Oulu University Hospital, Oulu, Finland.
authors: Minna E
authors: ME
authors: Kubin
authors: Department of Pathology, University of Oulu and Oulu University Hospital, Oulu, Finland.
authors: Matti
authors: M
authors: Kallioinen
authors: Unit for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland.
authors: Harri
authors: H
authors: Alenius
authors: PEDEGO Research Center, Department of Dermatology, University of Oulu, Oulu, Finland.|Medical Research Center Oulu (MRC Oulu), Oulu University Hospital, Oulu, Finland.
authors: Kaisa
authors: K
authors: Tasanen
authors: Department of Dermatology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors: Antti
authors: A
authors: Lauerma
mesh_terms: D000152:Acne Vulgaris / Q000097:blood / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D016207:Cytokines / Q000097:blood; D003879:Dermatologic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D012867:Skin / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D055815:Young Adult
chemical_list: D016207:Cytokines; D003879:Dermatologic Agents; D015474:Isotretinoin
keywords: IL-17; acne; inflammation; isotretinoin