title: Stability-indicating methods for the analysis of ciprofloxacin in the presence of its acid induced degradation product: A comparative study.
abstract: Four rapid, simple, accurate and precise spectrophotometric methods were used for the determination of ciprofloxacin in the presence of its acidic degradation product. The methods under study are ratio derivative, ratio difference, mean centering and dual wavelength. All the methods were validated according to the ICH guidelines and the obtained accuracy, precision and repeatability were found to be within the acceptable limits. The selectivity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. So, they can be used for the routine analysis of ciprofloxacin in quality-control laboratories.
authors: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751 Nasr City, Cairo, Egypt.
authors: Khalid A M
authors: KA
authors: Attia
authors: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751 Nasr City, Cairo, Egypt.
authors: Mohammed W I
authors: MW
authors: Nassar
authors: Analytical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), 12582 Al Hadaba Al Wosta, Cairo, Egypt.
authors: Mohamed B
authors: MB
authors: El-Zeiny
authors: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751 Nasr City, Cairo, Egypt. Electronic address: Ahmedserag777@hotmail.com.
authors: Ahmed
authors: A
authors: Serag
mesh_terms: D000143:Acids / Q000032:analysis; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002939:Ciprofloxacin / Q000032:analysis*; D004355:Drug Stability; D057230:Limit of Detection; D015203:Reproducibility of Results; D013053:Spectrophotometry / Q000191:economics / Q000379:methods*
chemical_list: D000143:Acids; D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin
keywords: Ciprofloxacin; Dual wavelength; Mean centering; Ratio derivative; Ratio difference; Stability-indicating