title: Multifunctional Gold-Mesoporous Silica Nanocomposites for Enhanced Two-Photon Imaging and Therapy of Cancer Cells.
abstract: Three dimensional sub-micron resolution has made two-photon nanomedicine a very promising medical tool for cancer treatment since current techniques cause significant side effects for lack of spatial selectivity. Two-photon-excited (TPE) photodynamic therapy (PDT) has been achieved via mesoporous nanoscaffolds, but the efficiency of the treatment could still be improved. Herein, we demonstrate the enhancement of the treatment efficiency via gold-mesoporous organosilica nanocomposites for TPE-PDT in cancer cells when compared to mesoporous organosilica particles. We performed the first comparative study of the influence of the shape and spatial position of gold nanoparticles (AuNPs) with mesoporous silica nanoparticles (MSN) functionalized with thiol groups and doped with a two-photon electron donor (2PS). The resulting multifunctional nanocarriers displayed TPE-fluorescence and were imaged inside cells. Furthermore, mesoporous organosilica NPs decorated gold nanospheres (AuNSs) induced 63 percent of selective killing on MCF-7 breast cancer cells. This study thus provides insights for the design of more effective multifunctional two-photon-sensitive nanocomposites via AuNPs for biomedical applications.
authors: Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1 Montpellier, France.
authors: Jonas G
authors: JG
authors: Croissant
authors: Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1 Montpellier, France.
authors: Christian
authors: C
authors: Qi
authors: NanoMedSyn, 2 - Faculté de Pharmacie Montpellier, France.
authors: Marie
authors: M
authors: Maynadier
authors: Institut NEEL, CNRS, Université Grenoble Alpes Grenoble, France.
authors: Xavier
authors: X
authors: Cattoën
authors: Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1 Montpellier, France.
authors: Michel
authors: M
authors: Wong Chi Man
authors: Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1 Montpellier, France.
authors: Laurence
authors: L
authors: Raehm
authors: Institut Des Sciences Chimiques de Rennes, CNRS UMR 6226 Université Rennes 1 Rennes, France.
authors: Olivier
authors: O
authors: Mongin
authors: University of Bordeaux, Institut des Sciences Moléculaires, UMR CNRS 5255 Talence, France.
authors: Mireille
authors: M
authors: Blanchard-Desce
authors: Institut des Biomolécules Max Mousseron UMR 5247 CNRS; UM 1; UM 2 - Faculté de Pharmacie, Université Montpellier Montpellier, France.
authors: Marcel
authors: M
authors: Garcia
authors: Institut des Biomolécules Max Mousseron UMR 5247 CNRS; UM 1; UM 2 - Faculté de Pharmacie, Université Montpellier Montpellier, France.
authors: Magali
authors: M
authors: Gary-Bobo
authors: Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1 Montpellier, France.
authors: Jean-Olivier
authors: JO
authors: Durand
keywords: gold nanoparticles; mesoporous silica nanoparticles; organic-inorganic; photodynamic therapy; two-photon