title: [Meta-analysis on relationship between single nucleotide polymorphism of rs2231142 in ABCG2 gene and gout in East Asian population].
abstract: OBJECTIVE
  To systematically evaluate the association between single nucleotide polymorphism of rs2231142 genetic susceptibility and gout in East Asian population.
  
  
  METHODS
  The literature retrieval was conducted by using English databases (Medline, EMbase), Chinese databases (CNKI, Vip, Wanfang, SinaMed) and others to collect the published papers on the association between single nucleotide polymorphism of rs2231142 genetic susceptibility and gout by the end of December 2014. Meta-analysis was performed with software Stata 12.0.
  
  
  RESULTS
  Nine studies were included. There were significant associations between increased risk of gout and single nucleotide polymorphism of rs2231142, the combined OR was 2.04 (95%CI: 1.82-2.28) for A allele and C allele, 1.97 (95%CI: 1.57-2.48) for CA and CC, 3.71 (95%CI: 3.07-4.47) for AA and CC. Sex and region specific subgroup analysis showed less heterogeneity.
  
  
  CONCLUSIONS
  There is significant association between gout and single nucleotide polymorphism of rs2231142 in East Asian population, and A allele is a high risk gene for gout.
authors: Department of Epidemiology, Institute of Geriatrics; Beijing Key Laboratory of Research on Aging and Related Diseases.
authors: Lei
authors: L
authors: Wu
authors: Department of Epidemiology, Institute of Geriatrics; Beijing Key Laboratory of Research on Aging and Related Diseases; State Key Laboratory of Kidney Disease, General Hospital of Chinese People's Liberation Army, Beijing 100853, China; Email: yhe301@sina.com.
authors: Yao
authors: Y
authors: He
authors: Department of Epidemiology, Institute of Geriatrics; Beijing Key Laboratory of Research on Aging and Related Diseases.
authors: Di
authors: D
authors: Zhang
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000483:Alleles; D044466:Asian People; D020022:Genetic Predisposition to Disease; D006073:Gout / Q000235:genetics*; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D009363:Neoplasm Proteins