title: Microfluidics-mediated assembly of functional nanoparticles for cancer-related pharmaceutical applications.
abstract: The controlled synthesis of functional nanoparticles with tunable structures and properties has been extensively investigated for cancer treatment and diagnosis. Among a variety of methods for fabrication of nanoparticles, microfluidics-based synthesis enables enhanced mixing and precise fluidic modulation inside microchannels, thus allowing for the flow-mediated production of nanoparticles in a controllable manner. This review focuses on recent advances of using microfluidic devices for the synthesis of drug-loaded nanoparticles with specific characteristics (such as size, composite, surface modification, structure and rigidity) for enhanced cancer treatment and diagnosis as well as to investigate the bio-nanoparticle interaction. The discussion on microfluidics-based synthesis may shed light on the rational design of functional nanoparticles for cancer-related pharmaceutical applications.
authors: Beijing Engineering Research Center for BioNanotechnology & CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China. xingyujiang@nanoctr.cn sunjs@nanoctr.cn.
authors: Qiang
authors: Q
authors: Feng
authors: Jiashu
authors: J
authors: Sun
authors: Xingyu
authors: X
authors: Jiang
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D056656:Lab-On-A-Chip Devices; D044085:Microfluidics / Q000379:methods*; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy*
chemical_list: D004337:Drug Carriers