title: Comparison of methods for identifying small-for-gestational-age infants at risk of perinatal mortality among obese mothers: a hospital-based cohort study.
abstract: To assess differences in small-for-gestational age (SGA) classifications for the detection of neonates with increased perinatal mortality risk among obese women and subsequently assess the association between prepregnancy body mass index (BMI) status and SGA.
  
  
  
  Hospital-based cohort.
  
  
  
  Twelve US clinical centres (2002-08).
  
  
  
  A total of 114 626 singleton, nonanomalous pregnancies.
  
  
  
  Data were collected using electronic medical record abstraction. Relative risks (RR) with 95% CI were estimated.
  
  
  
  SGA trends (birthweight < 10th centile) classified using population-based (SGAPOP), intrauterine (SGAIU) and customised (SGACUST) references were assessed. The SGA-associated perinatal mortality risk was estimated among obese women. Using the SGA method most associated with perinatal mortality, the association between prepregnancy BMI and SGA was estimated.
  
  
  
  The overall perinatal mortality prevalence was 0.55% and this increased significantly with increasing BMI (P < 0.01). Among obese women, SGAIUdetected the highest proportion of perinatal mortality cases (2.49%). Perinatal mortality was 5.32 times (95% CI 3.72-7.60) more likely among SGAIUneonates than non-SGAIUneonates. This is in comparison with the 3.71-fold (2.49-5.53) and 4.81-fold (3.41-6.80) increased risk observed when SGAPOPand SGACUSTwere used, respectively. Compared with women of normal weight, overweight women (RR = 0.82, 95% CI 0.78-0.86) and obese women (RR = 0.80; 95% CI 0.75-0.83) had a lower risk for delivering an SGAIUneonate.
  
  
  
  Among obese women, the intrauterine reference best identified neonates at risk of perinatal mortality. Based on SGAIU, SGA is less common among obese women but these SGA babies are at a high risk of death and remain an important group for surveillance.
  
  
  
  SGA is less common among obese women but these SGA babies are at a high risk of death.
authors: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors: S N
authors: SN
authors: Hinkle
authors: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors: L A
authors: LA
authors: Sjaarda
authors: Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors: P S
authors: PS
authors: Albert
authors: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors: P
authors: P
authors: Mendola
authors: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. katherine.grantz@mail.nih.gov.
authors: K L
authors: KL
authors: Grantz
mesh_terms: D001724:Birth Weight; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007236:Infant, Small for Gestational Age; D009035:Mothers; D054238:Perinatal Mortality; D011247:Pregnancy
keywords: Birthweight; fetal growth; obesity; small-for-gestational-age