title: Circulating resistin concentrations are independently associated with aortic pulse wave velocity in a community sample.
abstract: OBJECTIVE
  The role of the adipokine, resistin in mediating increases in aortic stiffness is uncertain. We aimed to determine independent relations between circulating resistin concentrations and aortic pulse wave velocity (PWV) and wave reflection in a community-based sample with a high prevalence of untreated hypertension and obesity.
  
  
  METHODS
  Plasma resistin, adiponectin, and C-reactive protein concentrations (ELISA); carotid-femoral (aortic) PWV and the aortic reflected wave index (applanation tonometry and SphygmoCor software) were determined in 683 randomly selected participants of African ancestry from SOWETO, South Africa who had never received antihypertensive therapy.
  
  
  RESULTS
  Resistin concentrations were not independently associated with office or 24-h (n = 492) blood pressure (BP). In a stepwise regression model with BMI included in the model, age (P < 0.0001), mean arterial pressure (P < 0.0001), plasma resistin concentrations (P < 0.005), female sex (P = 0.01), and creatinine concentrations (P < 0.01) contributed independently to variations in PWV. Independent relations between resistin concentrations and PWV persisted with further adjustments for C-reactive protein concentrations (P < 0.005), and the homeostasis model of insulin resistance (P < 0.02). Similar relations were noted with waist circumference rather than BMI in the model. Resistin concentrations were not independently associated with aortic reflected wave index or aortic BP.
  
  
  CONCLUSIONS
  Resistin is independently and directly associated with aortic stiffness and these effects occur beyond BP, insulin resistance, and general inflammation.
authors: Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa*Glenda Norman, Gavin R. Norton, and Angela J. Woodiwiss contributed equally to the writing of this article.
authors: Glenda
authors: G
authors: Norman
authors: Gavin R
authors: GR
authors: Norton
authors: Monica
authors: M
authors: Gomes
authors: Frederic
authors: F
authors: Michel
authors: Olebogeng H I
authors: OH
authors: Majane
authors: Pinhas
authors: P
authors: Sareli
authors: Aletta M E
authors: AM
authors: Millen
authors: Angela J
authors: AJ
authors: Woodiwiss
mesh_terms: D052242:Adiponectin; D000328:Adult; D001011:Aorta / Q000503:physiopathology*; D062186:Arterial Pressure / Q000502:physiology; D044383:Black People; D015992:Body Mass Index; D002097:C-Reactive Protein; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology; D063177:Pulse Wave Analysis; D052243:Resistin / Q000097:blood*; D013019:South Africa; D059289:Vascular Stiffness; D055105:Waist Circumference; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D052243:Resistin; D002097:C-Reactive Protein