title: All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters.
abstract: We report on the ion beam fabrication of all-carbon multi electrode arrays (MEAs) based on 16 graphitic micro-channels embedded in single-crystal diamond (SCD) substrates. The fabricated SCD-MEAs are systematically employed for the in vitro simultaneous amperometric detection of the secretory activity from populations of chromaffin cells, demonstrating a new sensing approach with respect to standard techniques. The biochemical stability and biocompatibility of the SCD-based device combined with the parallel recording of multi-electrodes array allow: i) a significant time saving in data collection during drug screening and/or pharmacological tests over a large number of cells, ii) the possibility of comparing altered cell functionality among cell populations, and iii) the repeatition of acquisition runs over many cycles with a fully non-toxic and chemically robust bio-sensitive substrate.
authors: Istituto Nazionale di Fisica Nucleare (INFN) Sez. Torino; via P. Giuria 1, 10125, Torino, Italy.|Physics Department and "NIS" Inter-departmental Centre - University of Torino; via P. Giuria 1, 10125, Torino, Italy.|Consorzio Nazionale Inter-universitario per le Scienze fisiche della Materia (CNISM) Sez. Torino, Italy.
authors: Federico
authors: F
authors: Picollo
authors: Istituto Nazionale di Fisica Nucleare (INFN) Sez. Torino; via P. Giuria 1, 10125, Torino, Italy.|Physics Department and "NIS" Inter-departmental Centre - University of Torino; via P. Giuria 1, 10125, Torino, Italy.|Consorzio Nazionale Inter-universitario per le Scienze fisiche della Materia (CNISM) Sez. Torino, Italy.
authors: Alfio
authors: A
authors: Battiato
authors: Istituto Nazionale di Fisica Nucleare (INFN) Sez. Torino; via P. Giuria 1, 10125, Torino, Italy.|Physics Department and "NIS" Inter-departmental Centre - University of Torino; via P. Giuria 1, 10125, Torino, Italy.|Consorzio Nazionale Inter-universitario per le Scienze fisiche della Materia (CNISM) Sez. Torino, Italy.
authors: Ettore
authors: E
authors: Bernardi
authors: Physics Department and "NIS" Inter-departmental Centre - University of Torino; via P. Giuria 1, 10125, Torino, Italy.
authors: Marilena
authors: M
authors: Plaitano
authors: Consorzio Nazionale Inter-universitario per le Scienze fisiche della Materia (CNISM) Sez. Torino, Italy.|Drug Science and Technology Department and "NIS" Inter-departmental Centre - University of Torino; Corso Raffaello 30, 10125, Torino, Italy.
authors: Claudio
authors: C
authors: Franchino
authors: Consorzio Nazionale Inter-universitario per le Scienze fisiche della Materia (CNISM) Sez. Torino, Italy.|Drug Science and Technology Department and "NIS" Inter-departmental Centre - University of Torino; Corso Raffaello 30, 10125, Torino, Italy.
authors: Sara
authors: S
authors: Gosso
authors: Institute of Electron Devices and Circuits - University of Ulm - Ulm; Albert Einstein Allee 45, 89069, Germany.
authors: Alberto
authors: A
authors: Pasquarelli
authors: Consorzio Nazionale Inter-universitario per le Scienze fisiche della Materia (CNISM) Sez. Torino, Italy.|Drug Science and Technology Department and "NIS" Inter-departmental Centre - University of Torino; Corso Raffaello 30, 10125, Torino, Italy.
authors: Emilio
authors: E
authors: Carbone
authors: Istituto Nazionale di Fisica Nucleare (INFN) Sez. Torino; via P. Giuria 1, 10125, Torino, Italy.|Physics Department and "NIS" Inter-departmental Centre - University of Torino; via P. Giuria 1, 10125, Torino, Italy.|Consorzio Nazionale Inter-universitario per le Scienze fisiche della Materia (CNISM) Sez. Torino, Italy.
authors: Paolo
authors: P
authors: Olivero
authors: Consorzio Nazionale Inter-universitario per le Scienze fisiche della Materia (CNISM) Sez. Torino, Italy.|Drug Science and Technology Department and "NIS" Inter-departmental Centre - University of Torino; Corso Raffaello 30, 10125, Torino, Italy.
authors: Valentina
authors: V
authors: Carabelli
mesh_terms: D000818:Animals; D002417:Cattle; D019439:Chromaffin Cells / Q000166:cytology / Q000378:metabolism*; D018130:Diamond; D004566:Electrodes; D018377:Neurotransmitter Agents / Q000032:analysis* / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D018377:Neurotransmitter Agents; D018130:Diamond