title: Effect of Nd:YAG laser-assisted non-surgical periodontal therapy on clinical periodontal and serum biomarkers in patients with and without coronary artery disease: A short-term pilot study.
abstract: We hypothesized that nonsurgical-periodontal-therapy (NSPT) with adjunct Nd:YAG laser therapy is more effective in reducing periodontal inflammatory parameters (plaque index [PI], bleeding-on-probing [BOP], and probing-pocket-depth [PPD]) and serum interleukin-1beta (IL-1β) and matrix metalloproteinase-9 (MMP-9) levels in patients with and without coronary artery disease (CAD) than NSPT alone. The aim of this short-term pilot study was to assess the effect of NSPT + Nd:YAG laser therapy on periodontal parameters and serum IL-1β and MMP-9 levels in patients with and without CAD.
  
  
  
  A prospective randomized clinical study was conducted on 87 patients who were divided into two groups: Group-1: 44 patients with CAD and periodontal disease (PD) and Group-2: 43 patients with PD alone. Treatment-wise, these individuals were randomly divided into two subgroups: (i) NSPT alone and (ii) NSPT + Nd:YAG laser therapy. Demographic information was collected using a self-completed questionnaire. Periodontal parameters (PI, BOP, and PPD) and serum IL-1β and MMP-9 levels were measured at baseline and after 3 months of treatment. P-values <0.05 were considered statistically significant.
  
  
  
  At 3 months follow-up, PI (P < 0.01), BOP (P < 0.01), PPD ≥ 4 mm (P < 0.01), and serum IL-1β (P < 0.01) and MMP-9 (P < 0.01) levels were significantly higher in patients treated with NSPT alone than those treated with NSPT + Nd:YAG laser therapy. Among patients that underwent NSPT + laser therapy in both groups, periodontal parameters and serum IL-1β, and MMP-9 levels were comparable at 3-months follow-up.
  
  
  
  NSPT + Nd:YAG laser therapy may be more effective in reducing periodontal inflammation and serum IL-1β and MMP-9 levels in patients with and without CAD than NSPT alone. Lasers Surg. Med. 48:929-935, 2016. © 2016 Wiley Periodicals, Inc.
authors: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York.
authors: Fawad
authors: F
authors: Javed
authors: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York.
authors: Sergio V
authors: SV
authors: Kellesarian
authors: Dental Biomaterials Research Chair, Department of Dental Health, College of Applied Medical Sciences, King Saud University, Riyadh, 11541, Saudi Arabia.
authors: Abdulaziz A
authors: AA
authors: Al-Kheraif
authors: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York.
authors: Vinisha
authors: V
authors: Ranna
authors: Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
authors: Talat
authors: T
authors: Qadri
authors: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York.
authors: Michael
authors: M
authors: Yunker
authors: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York.
authors: Hans
authors: H
authors: Malmstrom
authors: Department of Periodontology, School of Dental Medicine, University of Stony Brook, New York.|Department of Oral Surgery and Implant Dentistry, University of Johann Wolfgang, Frankfurt, Germany.
authors: Georgios E
authors: GE
authors: Romanos
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D010510:Periodontal Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D010517:Periodontics / Q000379:methods*; D010865:Pilot Projects; D011446:Prospective Studies; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D020780:Matrix Metalloproteinase 9
keywords: coronary artery disease; laser; non-surgical periodontal therapy; periodontal inflammation