title: Interictal Electroencephalography (EEG) Findings in Children with Epilepsy and Bilateral Brain Lesions on Magnetic Resonance Imaging (MRI).
abstract: BACKGROUND
  Neuroimaging procedures and electroencephalography (EEG) are basic parts of investigation of patients with epilepsies.
  
  
  OBJECTIVE
  The aim is to try to assess relationship between bilaterally localized brain lesions found in routine management of children with newly diagnosed epilepsy and their interictal EEG findings.
  
  
  METHODS
  Total amount of 68 patients filled criteria for inclusion in the study that was performed at Neuropediatrics Department, Pediatric Hospital, University Clinical Center Sarajevo, or its outpatient clinic. There were 33 girls (48,5%) and 35 boys (51,5%). Average age at diagnosis of epilepsy was 3,5 years.
  
  
  RESULTS
  Both neurological and neuropsychological examination in the moment of making diagnosis of epilepsy was normal in 27 (39,7%) patients, and showed some kind of delay or other neurological finding in 41 (60,3%). Brain MRI showed lesions that can be related to antenatal or perinatal events in most of the patients (ventricular dilation in 30,9%, delayed myelination and post-hypoxic changes in 27,9%). More than half of patients (55,9%) showed bilateral interictal epileptiform discharges on their EEGs, and further 14,7% had other kinds of bilateral abnormalities. Frequency of bilateral epileptic discharges showed statistically significant predominance on level of p<0,05. Cross tabulation between specific types of bilateral brain MRI lesions and EEG finding did not reveal significant type of EEG for assessed brain lesions.
  
  
  CONCLUSIONS
  We conclude that there exists relationship between bilaterally localized brain MRI lesions and interictal bilateral epileptiform or nonspecific EEG findings in children with newly diagnosed epilepsies. These data are suggesting that in cases when they do not correlate there is a need for further investigation of seizure etiology.
authors: Pediatric Hospital, University Clinical Center Sarajevo, Bosnia and Herzegovina.
authors: Smail
authors: S
authors: Zubcevic
authors: Pediatric Hospital, University Clinical Center Sarajevo, Bosnia and Herzegovina.
authors: Maja
authors: M
authors: Milos
authors: Pediatric Hospital, University Clinical Center Sarajevo, Bosnia and Herzegovina.
authors: Feriha
authors: F
authors: Catibusic
authors: Pediatric Hospital, University Clinical Center Sarajevo, Bosnia and Herzegovina.
authors: Sajra
authors: S
authors: Uzicanin
authors: Pediatric Hospital, University Clinical Center Sarajevo, Bosnia and Herzegovina.
authors: Belma
authors: B
authors: Krdzalic
keywords: bilateral lesions; brain MRI; children; interictal EEG