title: Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer's Disease.
abstract: Individuals diagnosed with mild cognitive impairment (MCI) are at high risk of transition to Alzheimer's disease (AD). However, little is known about functional characteristics of the conversion from MCI to AD. Resting-state functional magnetic resonance imaging was performed in 25 AD patients, 31 MCI patients, and 42 well-matched normal controls at baseline. Twenty-one of the 31 MCI patients converted to AD at approximately 24 months of follow-up. Functional connectivity strength (FCS) and seed-based functional connectivity analyses were used to assess the functional differences among the groups. Compared to controls, subjects with MCI and AD showed decreased FCS in the default-mode network and the occipital cortex. Importantly, the FCS of the left angular gyrus and middle occipital gyrus was significantly lower in MCI-converters as compared with MCI-nonconverters. Significantly decreased functional connectivity was found in MCI-converters compared to nonconverters between the left angular gyrus and bilateral inferior parietal lobules, dorsolateral prefrontal and lateral temporal cortices, and the left middle occipital gyrus and right middle occipital gyri. We demonstrated gradual but progressive functional changes during a median 2-year interval in patients converting from MCI to AD, which might serve as early indicators for the dysfunction and progression in the early stage of AD.
authors: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, China; Department of Neurology, Tangshan Gongren Hospital, Tangshan 063000, China.
authors: Yuxia
authors: Y
authors: Li
authors: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, China.
authors: Xiaoni
authors: X
authors: Wang
authors: Department of Neurology, Tangshan Gongren Hospital, Tangshan 063000, China.
authors: Yongqiu
authors: Y
authors: Li
authors: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, China.
authors: Yu
authors: Y
authors: Sun
authors: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, China.
authors: Can
authors: C
authors: Sheng
authors: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, China.
authors: Hongyan
authors: H
authors: Li
authors: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, China.
authors: Xuanyu
authors: X
authors: Li
authors: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, China.
authors: Yang
authors: Y
authors: Yu
authors: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, China.
authors: Guanqun
authors: G
authors: Chen
authors: Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany.
authors: Xiaochen
authors: X
authors: Hu
authors: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
authors: Bin
authors: B
authors: Jing
authors: Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Newterritories 000852, Hong Kong.
authors: Defeng
authors: D
authors: Wang
authors: Department of Radiology, XuanWu Hospital of Capital Medical University, Beijing 100053, China.
authors: Kuncheng
authors: K
authors: Li
authors: Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany.
authors: Frank
authors: F
authors: Jessen
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
authors: Mingrui
authors: 0000-0003-4615-9132
authors: M
authors: Xia
authors: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, China; Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing 100053, China.
authors: Ying
authors: Y
authors: Han
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D063132:Connectome; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology*