title: The Relationship between AMH and AMHR2 Polymorphisms and the Follicular Phase in Late Reproductive Stage Women.
abstract: The objective of this work was the analysis of the relationships between the genotypes of the AMH and AMH receptor type 2 genes, hormone levels and the menstrual cycle in a group of Polish women in the late reproductive stage. The study was conducted using a measurement-based method (body weight and height), laboratory method (serum hormone levels AMH, FSH and E2), and genetic analysis (DNA isolated from whole blood by a salting-out method). The study involved 345 healthy, late-reproductive-stage women from Poland, aged 42.3 ± 4.5 years. The analysis demonstrated that neither the T/T and G/T+G/G genotypes of the AMH Ile(49)Ser polymorphism (rs10407022), nor the A/A and the G/A + G/G genotypes of the AMHR2 2482 A > G polymorphism (rs2002555), nor the C/C and C/T + T/T genotypes of the AMH polymorphism (rs11170547) were statistically significantly related (p > 0.05) to such factors as age, BMI, hormone (FSH and E₂) levels and ovarian parameters (AMH) in the follicular phase. No relationships were found between ovarian parameters (FSH, E₂, AMH) and genetic variants of AMH (rs10407022) and AMHR2 (rs11170547, rs2002555) in healthy women in the late reproductive stage.
authors: Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska 48, 71-210 Szczecin, Poland. jurczaka@op.pl.
authors: Anna
authors: A
authors: Jurczak
authors: Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska 48, 71-210 Szczecin, Poland. m.szkup@onet.eu.
authors: Małgorzata
authors: M
authors: Szkup
authors: Department of Psychiatry, Pomeranian Medical University in Szczecin, Broniewskiego 26, 71-460 Szczecin, Poland. annagrzywacz@gazeta.pl.
authors: Anna
authors: A
authors: Grzywacz
authors: Department of Biochemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland. chrissaf@mp.pl.
authors: Krzysztof
authors: K
authors: Safranow
authors: Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska 48, 71-210 Szczecin, Poland. grochans@pum.edu.pl.
authors: Elżbieta
authors: E
authors: Grochans
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005498:Follicular Phase / Q000097:blood / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D018000:Receptors, Peptide / Q000097:blood / Q000235:genetics*; D018125:Receptors, Transforming Growth Factor beta / Q000097:blood / Q000235:genetics*; D012741:Sexual Maturation / Q000235:genetics* / Q000502:physiology
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; C084621:anti-Mullerian hormone receptor; D054304:Anti-Mullerian Hormone
keywords: AMH; AMHR2; follicular phase; late reproductive stage