title: Calcification on CT is a simple and valuable preoperative indicator of 1p/19q loss of heterozygosity in supratentorial brain tumors that are suspected grade II and III gliomas.
abstract: Gliomas with 1p/19q loss of heterozygosity (LOH) are known to be associated with longer patient survival and higher sensitivity to treatment than tumors without 1p/19q LOH. This study was designed to clarify whether the preoperative finding of calcification on CT was correlated with 1p/19q LOH in patients with suspected WHO grade II and III gliomas. This study included 250 adult patients who underwent resection for primary supratentorial tumors at Tokyo Women's Medical University Hospital. The tumors were suspected, based on MRI findings, to be WHO grade II or III gliomas. The presence of calcification on the patients' CT images was qualitatively evaluated before treatment. After surgery, the resected tumors were examined to determine their 1p/19q status and mutations of IDH1 and p53. The presence of calcification was significantly correlated with 1p/19q LOH (P < 0.0001), with a positive predictive value of 91 %. The tumors of all the 78 patients with calcification were diagnosed as oligodendroglial tumors. Seventy of these patients showed classic oligodendroglial features, while 8 patients showed non-classic features. Calcification on CT is a simple and valuable preoperative indicator of 1p/19q LOH in supratentorial brain tumors that are suspected to be WHO grade II and III gliomas.
authors: Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan. taiichis@gmail.com.|Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. taiichis@gmail.com.
authors: Taiichi
authors: T
authors: Saito
authors: Faculty of Advanced Techno-Surgery, Tokyo Women's Medical University, Tokyo, Japan.
authors: Yoshihiro
authors: Y
authors: Muragaki
authors: Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
authors: Takashi
authors: T
authors: Maruyama
authors: Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
authors: Takashi
authors: T
authors: Komori
authors: Faculty of Advanced Techno-Surgery, Tokyo Women's Medical University, Tokyo, Japan.
authors: Manabu
authors: M
authors: Tamura
authors: Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
authors: Masayuki
authors: M
authors: Nitta
authors: Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
authors: Shunsuke
authors: S
authors: Tsuzuki
authors: Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
authors: Takakazu
authors: T
authors: Kawamata
mesh_terms: D000328:Adult; D002114:Calcinosis; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D057234:Preoperative Period; D015173:Supratentorial Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology*; D014057:Tomography, X-Ray Computed
keywords: 1p/19q loss of heterozygosity; Calcification; Computed tomography; Glioma; IDH1