title: B Cells and Antibodies in Transplantation.
abstract: Overlooked for decades, the humoral alloimmune response is increasingly recognized as a leading cause of graft loss after transplantation. However, improvement in the diagnosis of antibody-mediated rejection has not yet translated into better outcomes for transplanted patients. After an update on B cell physiology and antibody generation, the 2015 Beaune Seminar in Transplant Research challenged the conventional view of antibody-mediated rejection pathophysiology and discussed the latest promising therapeutic approaches.
authors: 1 Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France. 2 Department of Nephrology, Dialysis and Renal Transplantation, University Hospital, Saint-Etienne, France. 3 Department of Nephrology and Transplantation, University Hospital, Dijon, France. 4 Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors: Alice
authors: A
authors: Koenig
authors: Christophe
authors: C
authors: Mariat
authors: Christiane
authors: C
authors: Mousson
authors: Kathryn J
authors: KJ
authors: Wood
authors: Gérard
authors: G
authors: Rifle
authors: Olivier
authors: O
authors: Thaunat
mesh_terms: D000906:Antibodies / Q000737:chemistry / Q000276:immunology*; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D003226:Congresses as Topic; D005602:France; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007108:Immune Tolerance; D056724:Immunity, Humoral; D007074:Immunoglobulin G / Q000737:chemistry; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D014180:Transplantation / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods*
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents