title: Colchicine Treatment for Tracheobronchial Amyloidosis.
abstract: Tracheobronchial amyloidosis is an infrequent disease characterized by the deposition of proteinaceous material in the tracheobronchial tree. The disease generally has a high morbidity and variable mortality in the years following diagnosis. There is no consensus on the optimal treatment. We report a case of a 63-year-old woman who presented with a diffuse tracheobronchial amyloidosis associated with laryngeal involvement, which required a percutaneous tracheostomy due to high-grade subglottic stenosis, with no evidence of systemic amyloidosis. After treatment exclusively with colchicine, she had a complete resolution of the stenotic area, with a very good response from the tracheobronchial amyloidosis disease, with only minor yellow plaques persisting. The patient has remained asymptomatic in the next 4 years of follow-up, with no evidence of endoscopic progression. This is the first documented case of this kind of response of tracheobronchial amyloidosis to colchicine treatment alone. A review of the available literature is presented.
authors: Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Catx00F3;lica de Chile, Santiago, Chile.
authors: Arturo
authors: A
authors: Morales
authors: Marizell
authors: M
authors: Pari
authors: Rosa
authors: R
authors: López-Lisbona
authors: Noelia
authors: N
authors: Cubero
authors: Jordi
authors: J
authors: Dorca
authors: Antoni
authors: A
authors: Rosell
mesh_terms: D000686:Amyloidosis / Q000188:drug therapy*; D001982:Bronchial Diseases / Q000188:drug therapy*; D003078:Colchicine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D014133:Tracheal Diseases / Q000188:drug therapy*; D050257:Tubulin Modulators / Q000627:therapeutic use*
chemical_list: D050257:Tubulin Modulators; D003078:Colchicine