title: Hypersensitivity reactions to platinum derivatives: findings of new predictive markers.
abstract: OBJECTIVE
  Platinum derivatives play a very important role in cancer therapy. Despite their outstanding results in the treatment of tumors with different locations, the occurrence of hypersensitivity reactions raises issues when it comes to therapy decision, because the changing of chemotherapy line could influence the tumor's evolution. Over the years the scientific community has paid particular attention to the mechanism by which this occurs and to identification of predictive factors. The purpose of this case-control, retrospective study was to find new predictive markers for the occurrence of allergic reactions to platinum derivatives.
  
  
  METHODS
  We identified 59 cases of allergic reactions to platinum derivatives in the Oncology Institute "Prof. Dr. Ion Chiricuta" from Cluj-Napoca city in 2013. Blood tests data were analyzed before the administration of the cycle on which the allergic reaction occurred, along with the mandatory analyses for the patients and we focused on the values of neutrophils, lymphocytes, monocytes, eosinophils and basophils.
  
  
  RESULTS
  When these values were compared with the values of the control group (,which was made at a ratio of 1:2 or 1:3, matched for age, tumor location and chemotherapy cycle) we found that each increase of lymphocytes or doses of platinum and each drop in monocytes number increased the risk for allergic reactions to occur.
  
  
  CONCLUSIONS
  These findings are of a great value for the physicians and represent a starting point for more detailed studies.
authors: Department of General and Inorganic Chemistry, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors: Sinziana
authors: S
authors: Cetean
authors: Tudor
authors: T
authors: Ciuleanu
authors: Daniel-Corneliu
authors: DC
authors: Leucuta
authors: Calin
authors: C
authors: Cainap
authors: Anne-Marie
authors: AM
authors: Constantin
authors: Irina
authors: I
authors: Cazacu
authors: Simona
authors: S
authors: Cainap
authors: Alexandra
authors: A
authors: Gherman
authors: Luminita
authors: L
authors: Oprean
authors: Adriana
authors: A
authors: Hangan
authors: Radu
authors: R
authors: Oprean
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers; D016190:Carboplatin / Q000009:adverse effects; D016022:Case-Control Studies; D002945:Cisplatin / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D006801:Humans; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D017671:Platinum Compounds / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D009944:Organoplatinum Compounds; D017671:Platinum Compounds; D000077150:Oxaliplatin; D016190:Carboplatin; D002945:Cisplatin