title: White matter tract integrity in treatment-resistant gambling disorder.
abstract: Gambling disorder is a relatively common psychiatric disorder recently re-classified within the DSM-5 under the category of 'substance-related and addictive disorders'.
  
  
  
  To compare white matter integrity in patients with gambling disorder with healthy controls; to explore relationships between white matter integrity and disease severity in gambling disorder.
  
  
  
  In total, 16 participants with treatment-resistant gambling disorder and 15 healthy controls underwent magnetic resonance imaging (MRI). White matter integrity was analysed using tract-based spatial statistics.
  
  
  
  Gambling disorder was associated with reduced fractional anisotropy in the corpus callosum and superior longitudinal fasciculus. Fractional anisotropy in distributed white matter tracts elsewhere correlated positively with disease severity.
  
  
  
  Reduced corpus callosum fractional anisotropy is suggestive of disorganised/damaged tracts in patients with gambling disorder, and this may represent a trait/vulnerability marker for the disorder. Future research should explore these measures in a larger sample, ideally incorporating a range of imaging markers (for example functional MRI) and enrolling unaffected first-degree relatives of patients.
authors: Samuel R. Chamberlain, MB/Bchir, PhD, MRCPsych, Department of Psychiatry, University of Cambridge, Cambridge and Cambridge and Peterborough NHS Foundation Trust (CPFT), Cambridge, UK; Katherine Derbyshire, BS, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA; Richard E. Daws, Msc, Computational, Cognitive & Clinical Neuroimaging Lab, Imperial College London, London, UK; Brian L. Odlaug, MPH, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Eric W. Leppink, BA, Jon E. Grant, JD, MD, MPH, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
authors: Samuel R
authors: SR
authors: Chamberlain
authors: Samuel R. Chamberlain, MB/Bchir, PhD, MRCPsych, Department of Psychiatry, University of Cambridge, Cambridge and Cambridge and Peterborough NHS Foundation Trust (CPFT), Cambridge, UK; Katherine Derbyshire, BS, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA; Richard E. Daws, Msc, Computational, Cognitive & Clinical Neuroimaging Lab, Imperial College London, London, UK; Brian L. Odlaug, MPH, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Eric W. Leppink, BA, Jon E. Grant, JD, MD, MPH, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
authors: Katherine
authors: K
authors: Derbyshire
authors: Samuel R. Chamberlain, MB/Bchir, PhD, MRCPsych, Department of Psychiatry, University of Cambridge, Cambridge and Cambridge and Peterborough NHS Foundation Trust (CPFT), Cambridge, UK; Katherine Derbyshire, BS, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA; Richard E. Daws, Msc, Computational, Cognitive & Clinical Neuroimaging Lab, Imperial College London, London, UK; Brian L. Odlaug, MPH, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Eric W. Leppink, BA, Jon E. Grant, JD, MD, MPH, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
authors: Richard E
authors: RE
authors: Daws
authors: Samuel R. Chamberlain, MB/Bchir, PhD, MRCPsych, Department of Psychiatry, University of Cambridge, Cambridge and Cambridge and Peterborough NHS Foundation Trust (CPFT), Cambridge, UK; Katherine Derbyshire, BS, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA; Richard E. Daws, Msc, Computational, Cognitive & Clinical Neuroimaging Lab, Imperial College London, London, UK; Brian L. Odlaug, MPH, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Eric W. Leppink, BA, Jon E. Grant, JD, MD, MPH, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
authors: Brian L
authors: BL
authors: Odlaug
authors: Samuel R. Chamberlain, MB/Bchir, PhD, MRCPsych, Department of Psychiatry, University of Cambridge, Cambridge and Cambridge and Peterborough NHS Foundation Trust (CPFT), Cambridge, UK; Katherine Derbyshire, BS, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA; Richard E. Daws, Msc, Computational, Cognitive & Clinical Neuroimaging Lab, Imperial College London, London, UK; Brian L. Odlaug, MPH, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Eric W. Leppink, BA, Jon E. Grant, JD, MD, MPH, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
authors: Eric W
authors: EW
authors: Leppink
authors: Samuel R. Chamberlain, MB/Bchir, PhD, MRCPsych, Department of Psychiatry, University of Cambridge, Cambridge and Cambridge and Peterborough NHS Foundation Trust (CPFT), Cambridge, UK; Katherine Derbyshire, BS, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA; Richard E. Daws, Msc, Computational, Cognitive & Clinical Neuroimaging Lab, Imperial College London, London, UK; Brian L. Odlaug, MPH, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Eric W. Leppink, BA, Jon E. Grant, JD, MD, MPH, Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA jongrant@uchicago.edu.
authors: Jon E
authors: JE
authors: Grant
mesh_terms: D000328:Adult; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005715:Gambling / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000473:pathology; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*