title: [Antimicrobial resistance: is it really all going wrong now?].
abstract: In November 2015, plasmid-mediated colistin resistance in Gram-negative bacteria was reported for the first time, and it was evident that this newly-identified resistance gene (mcr-1) was already prevalent in the animal and human reservoir in China. As well as massive media attention, there was also a massive scientific response. As of 22 January 2016, the interpretation of all the evidence is that the mcr-1 was already in existence in 2005 and is not bound to a single plasmid. Its presence has now been demonstrated on four continents and the gene seems widely prevalent in animal reservoirs across the globe, with a very low prevalence in collections of human isolates. Based on current findings there seems to be no reason to change clinical practices for Dutch patients.
authors: UMC Utrecht, afd. Medische Microbiologie, Utrecht.
authors: Marc J M
authors: MJ
authors: Bonten
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology*; D004197:Disease Reservoirs; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D015995:Prevalence
chemical_list: D000900:Anti-Bacterial Agents