title: The expression profile of filaggrin-2 in the normal and pathologic human oral mucosa.
abstract: The epithelial cells of the oral cavity show a remarkable degree of regional variation with respect to their morphology and keratinization status. In the oral cavity, the tongue and palate contain keratinizing stratified epithelia, while the buccal mucosa contains non-keratinizing stratified epithelia. We herein examined the expression of filaggrin-2, a member of the S100 fused-type protein family, in the oral mucosa. Filaggrin-2 was weakly expressed in the normal epithelium of the palate, but not in the buccal mucosa or tongue, although filaggrin protein was observed in the epithelium of the buccal mucosa and the palate. We next examined the expression of filaggrin-2 in the oral mucosa of subjects with hyperkeratotic diseases. The expression of filaggrin-2 was markedly increased in the epithelium of the oral mucosa in patients with lichen planus, leukokeratosis and leukoplakia. Filaggrin-2 positivity was observed in granules, some of which were co-localized with those of filaggrin. These results indicate that filaggrin-2 was expressed in the oral mucosa under certain pathological conditions, demonstrating that an aberrant protein expression, together with filaggrin, indicates the altered differentiation program including hyperkeratosis that occurs in these diseases.
authors: Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. tmakino@med.u-toyama.ac.jp.
authors: Teruhiko
authors: T
authors: Makino
authors: Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
authors: Megumi
authors: M
authors: Mizawa
authors: Department of Oral and Maxilla-facial Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
authors: Sayaka
authors: S
authors: Inoue
authors: Department of Oral and Maxilla-facial Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
authors: Makoto
authors: M
authors: Noguchi
authors: Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
authors: Tadamichi
authors: T
authors: Shimizu
mesh_terms: D004847:Epithelial Cells / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D000091344:Filaggrin Proteins; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D007972:Leukoplakia, Oral / Q000378:metabolism* / Q000473:pathology; D008010:Lichen Planus / Q000378:metabolism* / Q000473:pathology; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology; D010159:Palate / Q000378:metabolism / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism*; D014059:Tongue / Q000378:metabolism / Q000473:pathology
chemical_list: C000717249:FLG protein, human; C000717250:FLG2 protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D009418:S100 Proteins
keywords: Filaggrin; Filaggrin-2; Oral mucosa