title: Phosphoinositides in the nucleus and myogenic differentiation: how a nuclear turtle with a PHD builds muscle.
abstract: Phosphoinositides are a family of phospholipid messenger molecules that control various aspects of cell biology in part by interacting with and regulating downstream protein partners. Importantly, phosphoinositides are present in the nucleus. They form part of the nuclear envelope and are present within the nucleus in nuclear speckles, intra nuclear chromatin domains, the nuclear matrix and in chromatin. What their exact role is within these compartments is not completely clear, but the identification of nuclear specific proteins that contain phosphoinositide interaction domains suggest that they are important regulators of DNA topology, chromatin conformation and RNA maturation and export. The plant homeo domain (PHD) finger is a phosphoinositide binding motif that is largely present in nuclear proteins that regulate chromatin conformation. In the present study I outline how changes in the levels of the nuclear phosphoinositide PtdIns5P impact on muscle cell differentiation through the PHD finger of TAF3 (TAF, TATA box binding protein (TBP)-associated factor), which is a core component of a number of different basal transcription complexes.
authors: Centre for biological sciences, Building 84, Highfield Campus, University of Southampton, Southampton SO17 1BJ, U.K. INGM (Istituto Nazionale Genetica Molecolare), Padiglione ROMEO INVERNIZZI ed ENRICA PESSINA, Via Francesco Sforza, 35-20122 Milano, Italy n.divecha@soton.ac.uk.
authors: Nullin
authors: N
authors: Divecha
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D024510:Muscle Development; D009132:Muscles / Q000166:cytology / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D010716:Phosphatidylinositols
keywords: lipid kinase; myogenic differentiation; nucleus; phosphatidylinositol-5-phosphate; phosphoinositide; plant homology domain