title: Selenium deficiency induced damages and altered expressions of metalloproteinases and their inhibitors (MMP1/3, TIMP1/3) in the kidneys of growing rats.
abstract: Selenium is an essential trace element for the maintenance of structures and functions of kidney. To evaluate the effects of low selenium on the kidneys of growing rats, newborn rats were fed with selenium deficient and normal diets respectively for 109 days. As a result, rats fed with low selenium diets resulted in a decline in the body weight and the concentration of selenium in the kidney, especially the male rats from the low selenium groups. Moreover, the ultrastructure of glomerulus and tubules were damaged in low selenium group: the glomeruli were observed with hyperplasia of mesangial cells, fusion of podocyte foot processes and thickening of basement membrane; and the tubules were observed with vacuolar degenerated epithelial cells, increased edema fluid or protein solution between cells, microvilli edema, increased cell gaps and decreased cell links. Furthermore, the pathological changes in selenium deficient group included the increase of fibers around renal hilum aorta and in the renal collecting duct, and shed of cells in the proximal convoluted tubules. In addition, up-regulated expressions of matrix metalloproteinases (MMP1/3) and down-regulated expressions of their inhibitors (TIMP1/3) at the mRNA and protein levels were also appeared to be relevant to low selenium. The results suggested that low selenium in diet may cause low selenium concentration in the kidney of growing rat and lead to damages of the ultrastructure and extracellular matrix (ECM) of kidney.
authors: School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China. Electronic address: bbbishop@126.com.
authors: Jing
authors: J
authors: Han
authors: Department of Pathology, The first Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China. Electronic address: lianghua001@163.com.
authors: Hua
authors: H
authors: Liang
authors: School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China. Electronic address: laowei@mail.xjtu.edu.cn.
authors: Jianhua
authors: J
authors: Yi
authors: School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China. Electronic address: tanwh@mail.xjtu.edu.cn.
authors: Wuhong
authors: W
authors: Tan
authors: Department of Epidemiology and Biostatistics, School of Public Health, Ningxia Medical University, Yinchuan 750004, PR China. Electronic address: heshulan0954@163.com.
authors: Shulan
authors: S
authors: He
authors: School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China. Electronic address: 1028294561@qq.com.
authors: Xiaofang
authors: X
authors: Wu
authors: Department of Preventive Health Care, The first Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China. Electronic address: shilixiaowei@163.com.
authors: Xiaowei
authors: X
authors: Shi
authors: Institute for Endemic Disease Prevention and Control, Xining, Qinghai 811602, PR China. Electronic address: mjdjw@163.com.
authors: Jing
authors: J
authors: Ma
authors: School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China. Electronic address: guox@mail.xjtu.edu.cn.
authors: Xiong
authors: X
authors: Guo
mesh_terms: D000818:Animals; D005260:Female; D007668:Kidney / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics / Q000378:metabolism*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000172:deficiency* / Q000502:physiology; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics / Q000378:metabolism*; D019717:Tissue Inhibitor of Metalloproteinase-3 / Q000235:genetics / Q000378:metabolism*
chemical_list: D019715:Tissue Inhibitor of Metalloproteinase-1; D019717:Tissue Inhibitor of Metalloproteinase-3; D019278:Matrix Metalloproteinase 3; D020781:Matrix Metalloproteinase 1; D012643:Selenium
keywords: Damage; Kidney; MMP; Selenium deficiency; TIMP