title: Quantitative dynamic contrast-enhanced and diffusion-weighted MRI for differentiation between nasopharyngeal carcinoma and lymphoma at the primary site.
abstract: OBJECTIVE
  To investigate the value of quantitative dynamic contrast-enhanced MRI (QDCE-MRI) and diffusion-weighted MRI (DW-MRI) in differentiating nasopharyngeal carcinoma (NPC) from lymphoma.
  
  
  METHODS
  We retrospectively analysed the data from 102 patients (82 with NPC and 20 with lymphoma) who underwent pre-treatment QDCE-MRI and DW-MRI on a 1.5-T MR unit. QDEC-MRI parameters [influx transfer constant (K(trans)), efflux rate constant (Kep), fractional volume of extravascular extracellular space (Ve) and fractional volume of plasma (fPV)] based on pharmacokinetic model and apparent diffusion coefficient (ADC) were compared between the two nasopharyngeal malignancies.
  
  
  RESULTS
  The K(trans), Kep, Ve, fPV and ADC values (mean ± standard deviation) for NPC were 0.366 ± 0.155 min(-1), 1.353 ± 0.468 min(-1), 0.292 ± 0.117, 0.027 ± 0.024 and 0.981 ± 0.184 × 10(-3) mm(2) s(-1), respectively. The K(trans), Kep, Ve, fPV and ADC values (mean ± standard deviation) for lymphoma were 0.212 ± 0.059 min(-1), 1.073 ± 0.238 min(-1), 0.213 ± 0.104, 0.008 ± 0.007 and 0.760 ± 0.182 × 10(-3) mm(2) s(-1), respectively. Optimal cut-off values (area under the curve, sensitivity, specificity) for distinguishing the two tumours were as follows: K(trans) = 0.262 min(-1) (0.866, 80.49%, 85.00%), Kep = 1.401 min(-1) (0.681, 43.90%, 100.00%), Ve = 0.211 (0.784, 76.83%, 85.00%), fPV = 0.012 (0.779, 60.98%, 85.00%), ADC = 0.761 × 10(-3) mm(2) s(-1) (0.781, 93.90%, 55.00%).
  
  
  CONCLUSIONS
  QDCE-MRI together with DW-MRI is useful for differentiation between NPC and lymphoma.
authors: 1 Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.|2 Department of Radiology, the third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic China.
authors: Xiao-ping
authors: XP
authors: Yu
authors: 1 Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
authors: Jing
authors: J
authors: Hou
authors: 1 Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
authors: Fei-ping
authors: FP
authors: Li
authors: 1 Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
authors: Wang
authors: W
authors: Xiang
authors: 1 Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
authors: Qiang
authors: Q
authors: Lu
authors: 3 Department of Diagnostic Radiotherapy, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
authors: Yin
authors: Y
authors: Hu
authors: 3 Department of Diagnostic Radiotherapy, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
authors: Hui
authors: H
authors: Wang
mesh_terms: D019540:Area Under Curve; D002277:Carcinoma / Q000175:diagnosis*; D003287:Contrast Media; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data; D008223:Lymphoma / Q000175:diagnosis*; D016393:Lymphoma, B-Cell / Q000175:diagnosis; D016399:Lymphoma, T-Cell / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media
keywords: diffusion-weighted imaging; dynamic contrast-enhanced magnetic resonance imaging; nasopharyngeal carcinoma; nasopharyngeal lymphoma; sensitivity and specificity