title: Post-transplant survival in idiopathic pulmonary fibrosis patients concurrently listed for single and double lung transplantation.
abstract: Lung transplantation is a widely accepted treatment for patients with end-stage lung disease related to idiopathic pulmonary fibrosis (IPF). However, there are conflicting data on whether double lung transplant (DLT) or single lung transplant (SLT) is the superior therapy in these patients. The purpose of this study was to determine whether actuarial post-transplant graft survival among IPF patients concurrently listed for DLT and SLT is greater for recipients undergoing the former or the latter.
  
  
  
  The United Network for Organ Sharing provided de-identified patient-level data. Analysis included lung transplant candidates with IPF listed between January 1, 2001 and December 31, 2009 (n = 3,411). The study population included 1,001 (29.3%) lung transplant recipients concurrently listed for DLT and SLT, all ≥18 years of age. The primary outcome measure was actuarial post-transplant graft survival, expressed in years.
  
  
  
  Among the study population, 433 (43.26%) recipients underwent SLT and 568 (56.74%) recipients underwent DLT. The analysis included 2,722.5 years at risk, with median graft survival of 5.31 years. On univariate (p = 0.317) and multivariate (p = 0.415) regression analyses, there was no difference in graft survival between DLT and SLT.
  
  
  
  Among IPF recipients concurrently listed for DLT and SLT, there is no statistical difference in actuarial graft survival between recipients undergoing DLT vs SLT. This analysis suggests that increased use of SLT for IPF patients may increase the availability of organs to other candidates, and thus increase the net benefit of these organs, without measurably compromising outcomes.
authors: Department of Surgery, Rutgers-New Jersey Medical School, Newark, New Jersey; Cardiovascular Clinical Research Unit, Barnabas Heart Hospitals, Newark, New Jersey. Electronic address: dhavalchauhan86@gmail.com.
authors: Dhaval
authors: D
authors: Chauhan
authors: Cardiovascular Clinical Research Unit, Barnabas Heart Hospitals, Newark, New Jersey; Newark Beth Israel Medical Center, Barnabas Heart Hospitals, Newark, New Jersey.
authors: Ashwin B
authors: AB
authors: Karanam
authors: Cardiovascular Clinical Research Unit, Barnabas Heart Hospitals, Newark, New Jersey.
authors: Aurelie
authors: A
authors: Merlo
authors: Division of Pediatric and Congenital Cardiothoracic Surgery, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors: P A
authors: PA
authors: Tom Bozzay
authors: Newark Beth Israel Medical Center, Barnabas Heart Hospitals, Newark, New Jersey.
authors: Mark J
authors: MJ
authors: Zucker
authors: Newark Beth Israel Medical Center, Barnabas Heart Hospitals, Newark, New Jersey.
authors: Harish
authors: H
authors: Seethamraju
authors: Newark Beth Israel Medical Center, Barnabas Heart Hospitals, Newark, New Jersey.
authors: Nazly
authors: N
authors: Shariati
authors: Department of Surgery, Rutgers-New Jersey Medical School, Newark, New Jersey; Cardiovascular Clinical Research Unit, Barnabas Heart Hospitals, Newark, New Jersey; Newark Beth Israel Medical Center, Barnabas Heart Hospitals, Newark, New Jersey.
authors: Mark J
authors: MJ
authors: Russo
mesh_terms: D006085:Graft Survival; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis; D008168:Lung; D016040:Lung Transplantation; D011658:Pulmonary Fibrosis
keywords: UNOS/OPTN; idiopathic pulmonary fibrosis; lung transplantation; single vs. double lung transplant; survival analysis