title: Augmented immune responses in pigs immunized with an inactivated porcine reproductive and respiratory syndrome virus containing the deglycosylated glycoprotein 5 under field conditions.
abstract: OBJECTIVE
  Porcine reproductive and respiratory syndrome virus (PRRSV) leads to major economic losses in the swine industry. Vaccination is the most effective method to control the disease by PRRSV.
  
  
  METHODS
  In this study, the efficacy of a glycoprotein (GP) 5-modified inactivated vaccine was investigated in pigs. The study was performed in three farms: farm A, which was porcine reproductive and respiratory syndrome (PRRS)-negative, farm B (PRRS-active), which showed clinical signs of PRRS but had not used vaccines, and farm C (PRRS-stable), which had a history of endemic PRRS over the past years, but showed no more clinical signs after periodic administration of modified live virus vaccine.
  
  
  RESULTS
  The inactivated vaccine induced great enhancement in serum neutralizing antibody titer, which was sufficient to protect pigs from further infections of PRRSV in a farm where pre-existing virus was circulating.
  
  
  CONCLUSIONS
  These results indicated that vaccination with the inactivated vaccine composed of viruses possessing deglycosylated GP5 would provide enhanced protection to pigs from farms suffering from endemic PRRSV.
authors: College of Veterinary Medicine, Konkuk University, Seoul, Korea.; Division of Vaccine Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Korea.
authors: Jung-Ah
authors: 0000-0003-3699-3609
authors: JA
authors: Lee
authors: College of Veterinary Medicine, Konkuk University, Seoul, Korea.
authors: Nak-Hyung
authors: 0000-0002-4304-4949
authors: NH
authors: Lee
authors: College of Veterinary Medicine, Konkuk University, Seoul, Korea.
authors: Joong-Bok
authors: 0000-0003-1074-8162
authors: JB
authors: Lee
authors: College of Veterinary Medicine, Konkuk University, Seoul, Korea.
authors: Seung-Yong
authors: 0000-0001-8104-8775
authors: SY
authors: Park
authors: College of Veterinary Medicine, Konkuk University, Seoul, Korea.
authors: Chang-Seon
authors: 0000-0002-4158-6402
authors: CS
authors: Song
authors: College of Veterinary Medicine, Konkuk University, Seoul, Korea.
authors: In-Soo
authors: 0000-0001-7266-6571
authors: IS
authors: Choi
authors: College of Veterinary Medicine, Konkuk University, Seoul, Korea.
authors: Sang-Won
authors: 0000-0003-1956-7245
authors: SW
authors: Lee
keywords: Inactivated vaccines; Neutralization test; Porcine reproductive and respiratory syndrome virus