title: Murine Models Demonstrate Distinct Vasculogenic and Cardiomyogenic cKit+ Lineages in the Heart.
abstract: After 2 recent genetic studies in mice addressing the developmental origins and regenerative activity of cardiac cKit+ cells, 2 additional reports by Sultana et al and Liu et al provide further information on the expression of cKit in the embryonic and adult hearts. Here, we synthesize the findings from the 4 distinct cKit models to gain insights into the biology of this important cell type.
authors: From the Interdisciplinary Stem Cell Institute (K.E.H.), and Department of Medicine, Division of Cardiology and Department of Molecular and Cellular Pharmacology (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, FL.
authors: Konstantinos E
authors: KE
authors: Hatzistergos
authors: From the Interdisciplinary Stem Cell Institute (K.E.H.), and Department of Medicine, Division of Cardiology and Department of Molecular and Cellular Pharmacology (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, FL. jhare@med.miami.edu.
authors: Joshua M
authors: JM
authors: Hare
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D003331:Coronary Vessels / Q000196:embryology / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism*; D005838:Genotype; D006321:Heart / Q000196:embryology; D008822:Mice, Transgenic; D009024:Morphogenesis; D032383:Myocytes, Cardiac / Q000378:metabolism*; D010641:Phenotype; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000378:metabolism*
chemical_list: D019009:Proto-Oncogene Proteins c-kit
keywords: cell differentiation; cell- and tissue-based therapy; coronary vessels; endothelial cells; myocytes, cardiac