title: Lung cancer in HIV-infected patients and the role of targeted therapy.
abstract: Lung cancer is one of the most common malignancies in HIV-infected patients. Prevalence and mortality outcomes are higher in HIV-infected populations than in noninfected patients. There are several oral agents available for patients who harbor specific mutations, but little is known about mutations and affected pathways in HIV-infected patients with lung cancer. Recent trials have facilitated the inclusion of HIV-infected patients in clinical trials, but the population is remains underrepresented in oncology trials. Here, we review the literature on lung cancer in HIV-infected patients, and discuss common mutations in lung cancer and HIV-infected patients, the role of mutational analysis, and the potential role of targeted therapy in the treatment of lung cancer in HIV-infected populations.
authors: Section of Hematology Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. mruiz@lsuhsc.edu.
authors: Marco
authors: M
authors: Ruiz
authors: Section of Hematology Oncology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
authors: Robert A
authors: RA
authors: Ramirez
keywords: HIV; lung cancer; targeted therapy