title: Admixture, Population Structure, and F-Statistics.
abstract: Many questions about human genetic history can be addressed by examining the patterns of shared genetic variation between sets of populations. A useful methodological framework for this purpose isF-statistics that measure shared genetic drift between sets of two, three, and four populations and can be used to test simple and complex hypotheses about admixture between populations. This article provides context from phylogenetic and population genetic theory. I review how F-statistics can be interpreted as branch lengths or paths and derive new interpretations, using coalescent theory. I further show that the admixture tests can be interpreted as testing general properties of phylogenies, allowing extension of some ideas applications to arbitrary phylogenetic trees. The new results are used to investigate the behavior of the statistics under different models of population structure and show how population substructure complicates inference. The results lead to simplified estimators in many cases, and I recommend to replace F3 with the average number of pairwise differences for estimating population divergence.
authors: Department of Human Genetics, University of Chicago, Chicago, Illinois 60637 bpeter@uchicago.edu.
authors: Benjamin M
authors: http://orcid.org/0000-0003-2526-8081
authors: BM
authors: Peter
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D051456:Gene Flow; D040961:Genetic Drift; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D010802:Phylogeny
keywords: admixture; gene flow; phylogenetic network; phylogenetics; population genetics