title: Diagnostic value of high-resolution micro-endoscopy for the classification of colon polyps.
abstract: OBJECTIVE
  To study a new imaging equipment, high-resolution micro-endoscopy (HRME), in the diagnosis and pathological classification of colon polyps.
  
  
  METHODS
  We selected 114 specimens of colon polyps, 30 of which were colon polyps with known pathological types and 84 that were prospective polyp specimens; 10 normal colon mucosa specimens served as controls. We obtained images of 30 colon polyp specimens with known pathological types using HRME and analyzed the characteristics of these images to develop HRME diagnostic criteria for different pathological types of colon polyps. Based on these criteria, we performed a prospective study of 84 colon polyp specimens using HRME and compared the results with those of the pathological examination to evaluate the diagnostic value of HRME in the pathological classification of different types of colon polyps.
  
  
  RESULTS
  In the 30 cases of known pathological type of colon polyp samples, there were 21 cases of adenomatous polyps, which comprised nine cases of tubular adenoma, seven cases of villous adenoma and five cases of mixed adenomas. The nine cases of non-adenomatous polyps included four cases of inflammatory polyps and five cases of hyperplastic polyps five. Ten cases of normal colonic mucosa were confirmed pathologically. In a prospective study of 84 cases using HRME, 23 cases were diagnosed as inflammatory polyps, 11 cases as hyperplastic polyps, 18 cases as tubular adenoma, eight cases as villous adenoma and 24 cases as mixed adenomas. After pathological examination, 24 cases were diagnosed as inflammatory polyps, 11 cases as hyperplastic polyps, 19 cases as tubular adenoma, eight cases as villous adenoma and 22 cases as mixed adenomas. Compared with the pathological examinations, the sensitivities, specificities, accuracies, and positive and negative predictive values of HRME in diagnosing inflammatory polyps (87.5%, 96.7%, 94.0%, 91.3% and 95.1%), hyperplastic polyps (72.7%, 95.9%, 92.9%, 72.7% and 95.9%), tubular adenomas (73.7%, 93.8%, 89.3%, 77.8% and 92.4%), villous adenomas (75.0%, 97.4%, 95.2%, 75.0% and 97.4%), and mixed adenomas (75.0%, 93.3%, 88.1%, 81.8% and 90.3%) were relatively high.
  
  
  CONCLUSIONS
  HRME has a relatively high diagnostic value in the pathological classification of colon polyps. Thus, it may be an alternative to confocal microendoscopy in lower-resource or community-based settings.
authors: Tao Tan, Ya-Wei Qu, Juan Shu, Min-Li Liu, Ling Zhang, Hai-Feng Liu, Department of Gastroenterology, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
authors: Tao
authors: T
authors: Tan
authors: Tao Tan, Ya-Wei Qu, Juan Shu, Min-Li Liu, Ling Zhang, Hai-Feng Liu, Department of Gastroenterology, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
authors: Ya-Wei
authors: YW
authors: Qu
authors: Tao Tan, Ya-Wei Qu, Juan Shu, Min-Li Liu, Ling Zhang, Hai-Feng Liu, Department of Gastroenterology, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
authors: Juan
authors: J
authors: Shu
authors: Tao Tan, Ya-Wei Qu, Juan Shu, Min-Li Liu, Ling Zhang, Hai-Feng Liu, Department of Gastroenterology, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
authors: Min-Li
authors: ML
authors: Liu
authors: Tao Tan, Ya-Wei Qu, Juan Shu, Min-Li Liu, Ling Zhang, Hai-Feng Liu, Department of Gastroenterology, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
authors: Ling
authors: L
authors: Zhang
authors: Tao Tan, Ya-Wei Qu, Juan Shu, Min-Li Liu, Ling Zhang, Hai-Feng Liu, Department of Gastroenterology, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
authors: Hai-Feng
authors: HF
authors: Liu
mesh_terms: D018256:Adenomatous Polyps / Q000473:pathology*; D001706:Biopsy; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000473:pathology*; D003111:Colonic Polyps / Q000473:pathology*; D020685:Colonoscopes; D003113:Colonoscopy / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D008853:Microscopy / Q000295:instrumentation / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results
keywords: Colon polyps; Diagnostic criteria; High-resolution micro-endoscopy; Pathology