title: Biphasic effect of Syzygium aromaticum flower bud on reproductive physiology of male mice.
abstract: The flower buds of Syzygium aromaticum (clove) have been used for the treatment of male sexual disorders in indigenous medicines of Indian subcontinent. Therefore to evaluate the efficacy of Syzygium aromaticum on the male reproductive health, chronic oral exposure of aqueous extract of flower buds of Syzygium in three doses (15 mg, 30 mg and 60 mg kg-1BW) were studied for a single spermatogenic cycle (35 days) in Parkes (P) strain mice. Lower dose (15 mg) of Syzygium aromaticum flower buds increased serum testosterone level and testicular hydroxysteroid dehydrogenase (HSD) activities and improved sperm motility, sperm morphology, secretory activity of epididymis and seminal vesicle, and number of litters per female. On the other hand, higher doses (30 and 60 mg) of the treatment adversely affected above parameters. Further, higher doses of the extract also had adverse effects on daily sperm production, 1C cell population and on histology of testis. In conclusion, Syzygium aromaticum flower buds extract exhibits biphasic effect on reproductive physiology of male mice. Lower dose of Syzygium aromaticum flower bud extract is androgenic in nature and may have a viable future as an indigenous sexual rejuvenator, while higher doses adversely affected functional physiology of reproductive organs.
authors: Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.|Department of Zoology, Smt. Chandibai Himathmal Mansukhani College, University of Mumbai, Ulhasnagar, Thane, Maharashtra, India.
authors: R K
authors: RK
authors: Mishra
authors: Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India. shioks@rediffmail.com.
authors: S K
authors: SK
authors: Singh
mesh_terms: D000728:Androgens / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000502:physiology; D035264:Flowers; D005837:Genitalia, Male / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007194:India; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D013091:Spermatogenesis / Q000187:drug effects; D027842:Syzygium; D013739:Testosterone / Q000097:blood
chemical_list: D000728:Androgens; D010936:Plant Extracts; D013739:Testosterone
keywords: 
  Syzygium aromaticum
  ; fertility; flow cytometry; sperm dynamics; spermatogenesis