title: Guiding pharmacist clinical interviews: a safety tool to support the education of patients treated with oral antineoplastic agents.
abstract: OBJECTIVE
  Oral antineoplastic agents (OAA) lead to new challenges in patient education, monitoring, medication errors, drug interactions, adverse events management, and adherence. The aim is to develop a structured guide supporting pharmacist interviews and onco-hematologic outpatients' education process and to identify the key points that a pharmacist should address in order to increase OAA safety and efficacy.
  
  
  METHODS
  A literature review was performed and the recommended standards associated with OAA approved by ASCO and MASCC were analyzed. Additionally, a multidisciplinary team was formed to address the key points associated with OAA in clinical practice and to create a useful clinical guide.
  
  
  RESULTS
  The multidisciplinary team defined the safety and efficacy key points during patient education and issued recommendations regarding the following items: dose, drug administration, interactions, adverse events, adherence, literacy, quality of life, storage, and handling. A guide was created as a check-list in support of the pharmacist clinical interview. Implications for clinical practice, including adverse events management, drug interactions management, and interventions on adherence were added.
  
  
  CONCLUSIONS
  This article provides a consensus set of safety recommendations regarding OAA in clinical practice and a well-researched easily implementable support guide to standardize and guarantee quality pharmaceutical care of onco-hematologic outpatients.
authors: a Pharmacy Department , Gregorio Marañón University General Hospital, Instituto de Investigación Sanitaria Gregorio Marañón , Madrid , Spain.
authors: Almudena
authors: A
authors: Ribed
authors: a Pharmacy Department , Gregorio Marañón University General Hospital, Instituto de Investigación Sanitaria Gregorio Marañón , Madrid , Spain.
authors: Vicente
authors: V
authors: Escudero-Vilaplana
authors: a Pharmacy Department , Gregorio Marañón University General Hospital, Instituto de Investigación Sanitaria Gregorio Marañón , Madrid , Spain.
authors: Rosa Maria
authors: RM
authors: Romero-Jimenez
authors: b Pharmacology Department, College of Pharmacy, Complutense University , Madrid , Spain.
authors: Irene
authors: I
authors: Iglesias-Peinado
authors: a Pharmacy Department , Gregorio Marañón University General Hospital, Instituto de Investigación Sanitaria Gregorio Marañón , Madrid , Spain.
authors: Ana
authors: A
authors: Herranz-Alonso
authors: a Pharmacy Department , Gregorio Marañón University General Hospital, Instituto de Investigación Sanitaria Gregorio Marañón , Madrid , Spain.
authors: Maria
authors: M
authors: Sanjurjo-Saez
mesh_terms: D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D004347:Drug Interactions; D004356:Drug Storage / Q000592:standards; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control; D006801:Humans; D008508:Medication Errors; D010353:Patient Education as Topic / Q000379:methods*; D010595:Pharmacists / Q000592:standards*; D024382:Professional Role; D011788:Quality of Life; D012449:Safety
chemical_list: D000970:Antineoplastic Agents
keywords: Drug safety; oral chemotherapy; outpatient; patient education; pharmaceutical care