title: Bioinspired polydimethylsiloxane-based composites with high shear resistance against wet tissue.
abstract: Patterned microstructures represent a potential approach for improving current wound closure strategies. Microstructures can be fabricated by multiple techniques including replica molding of soft polymer-based materials. However, polymeric microstructures often lack the required shear resistance with tissue needed for wound closure. In this work, scalable microstructures made from composites based on polydimethylsiloxane (PDMS) were explored to enhance the shear resistance with wet tissue. To achieve suitable mechanical properties, PDMS was reinforced by incorporation of polyethylene (PE) particles into the pre-polymer and by coating PE particle reinforced substrates with parylene. The reinforced microstructures showed a 6-fold enhancement, the coated structures even a 13-fold enhancement in Young׳s modulus over pure PDMS. Shear tests of mushroom-shaped microstructures (diameter 450µm, length 1mm) against chicken muscle tissue demonstrate first correlations that will be useful for future design of wound closure or stabilization implants.
authors: INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany; Department of Materials Science and Engineering, Saarland University, Campus D2 2, 66123 Saarbrücken, Germany; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Biomedical Engineering, Department of Medicine, Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA 02139, USA.
authors: Sarah C L
authors: SCL
authors: Fischer
authors: Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Biomedical Engineering, Department of Medicine, Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA 02139, USA.
authors: Oren
authors: O
authors: Levy
authors: INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany.
authors: Elmar
authors: E
authors: Kroner
authors: INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany.
authors: René
authors: R
authors: Hensel
authors: Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Biomedical Engineering, Department of Medicine, Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA 02139, USA. Electronic address: jeffkarp.bwh@gmail.com.
authors: Jeffrey M
authors: JM
authors: Karp
authors: INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany; Department of Materials Science and Engineering, Saarland University, Campus D2 2, 66123 Saarbrücken, Germany. Electronic address: eduard.arzt@leibniz-inm.de.
authors: Eduard
authors: E
authors: Arzt
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002645:Chickens; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D008422:Materials Testing; D033081:Shear Strength; D013314:Stress, Mechanical; D014014:Tissue Adhesives / Q000737:chemistry*; D014945:Wound Healing
chemical_list: D004129:Dimethylpolysiloxanes; D014014:Tissue Adhesives
keywords: Bioinspired; Composite; Polydimethylsiloxan (PDMS); Shear resistance; Wound closure