title: Weight Loss, Xanthine Oxidase, and Serum Urate Levels: A Prospective Longitudinal Study of Obese Patients.
abstract: The mechanisms by which weight loss decreases serum uric acid (SUA) levels are poorly known. We aimed to investigate the role played by xanthine oxidase (XOD), metabolic status, and low-grade inflammation in decreased SUA levels induced by weight loss in obese patients.
  
  
  
  Data were from a series of consecutive patients with severe obesity involved in a bariatric surgery program. Measurements of body composition and biologic samples were obtained before surgery and 6 months after surgery.
  
  
  
  Among the 154 patients (mean ± SD age 41.0 ± 12.3 years, body mass index [BMI] 47.8 ± 7.2 kg/m(2) , 81% female), the mean ± SD weight loss at 6 months was 31.3 ± 7.8 kg. Reduction in SUA levels was modest (-10%): 4.98 ± 1.21 mg/dl at 6 months versus 5.52 ± 1.33 mg/dl at baseline (P < 0.001). The decrease in SUA levels was greatest (-18%) in hyperuricemic patients (n = 48). In these patients, circulating XOD activity decreased with weight loss (P < 0.0001). Multiple linear regression analysis revealed decreased SUA levels associated with decreased triglyceride levels (P = 0.0001) and BMI (P = 0.02) but not XOD activity, adipokine levels (leptin and adiponectin), insulin resistance, or levels of inflammatory variables (interleukin 6, orosomucoid, fibrinogen, and high-sensitivity C-reactive protein).
  
  
  
  In obese patients, weight loss was associated with a decrease in both SUA levels and XOD activity. Our findings suggest that reduced SUA levels are not mediated by decreased XOD activity or improved insulin resistance but could be partly due to a reduction in triglyceride levels.
authors: Université Paris 7, UFR médicale, Assistance Publique-Hôpitaux de Paris, and Hôpital Lariboisière, INSERM U1132, Paris, France.
authors: Pascal
authors: P
authors: Richette
authors: Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Institute of Cardiometabolism and Nutrition, and Sorbonne Universités, UPMC University Paris 06, INSERM UMR-S1166, F-75013, Paris, France.
authors: Christine
authors: C
authors: Poitou
authors: Assistance Publique-Hôpitaux de Paris and Hôpital Lariboisière, INSERM UMR-S942, Paris, France.
authors: Philippe
authors: P
authors: Manivet
authors: Assistance Publique-Hôpitaux de Paris and Hôpital Lariboisière, INSERM UMR-S942, Paris, France.
authors: Jérome
authors: J
authors: Denis
authors: Assistance Publique-Hôpitaux de Paris, Ambroise Paré University Hospital, Paris, France, and Versailles Saint-Quentin University, Boulogne, France.
authors: Jean-Luc
authors: JL
authors: Bouillot
authors: Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Institute of Cardiometabolism and Nutrition, and Sorbonne Universités, UPMC University Paris 06, INSERM UMR-S1166, F-75013, Paris, France.
authors: Karine
authors: K
authors: Clément
authors: Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Institute of Cardiometabolism and Nutrition, and Sorbonne Universités, UPMC University Paris 06, INSERM UMR-S1166, F-75013, Paris, France.
authors: Jean-Michel
authors: JM
authors: Oppert
authors: Université Paris 7, UFR médicale, Assistance Publique-Hôpitaux de Paris, and Hôpital Lariboisière, INSERM U1132, Paris, France.
authors: Thomas
authors: T
authors: Bardin
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000378:metabolism; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000378:metabolism* / Q000601:surgery; D011446:Prospective Studies; D014527:Uric Acid / Q000097:blood*; D015431:Weight Loss / Q000502:physiology*; D014969:Xanthine Oxidase / Q000378:metabolism*
chemical_list: D014527:Uric Acid; D014969:Xanthine Oxidase