title: Bias-Variance Tradeoffs in Recombination Rate Estimation.
abstract: In 2013, we and coauthors published a paper characterizing rates of recombination within the 2.1-megabase garnet-scalloped (g-sd) region of the Drosophila melanogaster X chromosome. To extract the signal of recombination in our high-throughput sequence data, we adopted a nonparametric smoothing procedure, reducing variance at the cost of biasing individual recombination rates. In doing so, we sacrificed accuracy to gain precision-precision that allowed us to detect recombination rate heterogeneity. Negotiating the bias-variance tradeoff enabled us to resolve significant variation in the frequency of crossing over across the garnet-scalloped region.
authors: Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27612 eastone2@ncsu.edu ndsingh@ncsu.edu.
authors: Eric A
authors: EA
authors: Stone
authors: Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27612 eastone2@ncsu.edu ndsingh@ncsu.edu.
authors: Nadia D
authors: ND
authors: Singh
mesh_terms: D000483:Alleles; D000818:Animals; D015982:Bias; D004331:Drosophila melanogaster / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D008957:Models, Genetic; D015233:Models, Statistical; D011995:Recombination, Genetic