title: Epidemiology of myasthenia gravis in Northern Portugal: Frequency estimates and clinical epidemiological distribution of cases.
abstract: In this study we estimated the prevalence, incidence, and mortality of myasthenia gravis (MG) in northern Portugal and characterized the clinical features of the patients identified.
  
  
  
  We used 2 data sources: clinical records from the hospitals and pyridostigmine prescription registers.
  
  
  
  On December 31, 2013, we estimated a point prevalence of 111.7 patients per million population. The highest prevalence was observed in the group >65 years of age, especially in men (288.1 per million). During 2013, we estimated an incidence rate of 6.3 per million per year. Among women, the incidence rate was highest in the 15-49-year age group; in men, incidence increased with age up to 22.1 per million in those >65 years old. The MG-related mortality rate was 0.5 per million.
  
  
  
  These figures are in keeping with similar studies and emphasize the importance of diagnosis and management of MG in elderly populations. Muscle Nerve 54: 413-421, 2016.
authors: Neurology Department, Hospital Santo Antonio, Centro Hospitalar Porto, Porto, Portugal.|Unit for Multidisciplinary Research in Biomedicine, Instituto de Ciencias Biomedicas de Abel Salazar, Universidade do Porto, Porto, Portugal.
authors: Ernestina
authors: E
authors: Santos
authors: Nuffield Department of Clinical Neurosciences, Oxford University Hospitals, University of Oxford, UK.
authors: Ester
authors: E
authors: Coutinho
authors: Neurology Department, Hospital Santo Antonio, Centro Hospitalar Porto, Porto, Portugal.
authors: Isabel
authors: I
authors: Moreira
authors: Neurology Department, Hospital Santo Antonio, Centro Hospitalar Porto, Porto, Portugal.|Unit for Multidisciplinary Research in Biomedicine, Instituto de Ciencias Biomedicas de Abel Salazar, Universidade do Porto, Porto, Portugal.
authors: Ana Martins
authors: AM
authors: Silva
authors: Centro Hospitalar do Porto, Porto, Portugal.
authors: Dina
authors: D
authors: Lopes
authors: Neurology Department, Hospital Sao Joao, Porto, Portugal.
authors: Henrique
authors: H
authors: Costa
authors: Neurology Department, Hospital Sao Joao, Porto, Portugal.
authors: Fernando
authors: F
authors: Silveira
authors: Neurology Department, Hospital Sao Joao, Porto, Portugal.
authors: Goreti
authors: G
authors: Nadais
authors: Neurology Department, Centro Hospitalar de Vila Nova de Gaia e Espinho, Gaia, Portugal.
authors: Hugo
authors: H
authors: Morais
authors: Neurology Department, Hospital Pedro Hispano, Matosinhos, Portugal.
authors: João
authors: J
authors: Martins
authors: Neurology Department, Hospital Pedro Hispano, Matosinhos, Portugal.|Neurology Department, Hospital de Sao Pedro, Centro Hospitalar do Trás-os-Montes e Alto Douro, Vila Real, Portugal.
authors: Maria Ceu
authors: MC
authors: Branco
authors: Neurology Department, Hospital de Sao Pedro, Centro Hospitalar do Trás-os-Montes e Alto Douro, Vila Real, Portugal.
authors: Andreia
authors: A
authors: Veiga
authors: Neurology Department, Centro Hospitalar do Alto Minho, Viana do Castelo, Portugal.
authors: Rosa Santos
authors: RS
authors: Silva
authors: Neurology Department, Centro Hospitalar Entre Douro e Vouga, Feira, Portugal.
authors: Augusto
authors: A
authors: Ferreira
authors: Neurology Department, Hospital de Braga, Braga, Portugal.
authors: Filipa
authors: F
authors: Sousa
authors: Neurology Department, Centro Hospitalar do Nordeste, Mirandela, Portugal.
authors: Marta
authors: M
authors: Freijo
authors: Neurology Department, Centro Hospitalar do Nordeste, Mirandela, Portugal.
authors: Ilda
authors: I
authors: Matos
authors: Neurology Department, Hospital de São Teotonio, Viseu, Portugal.
authors: Rui
authors: R
authors: André
authors: Neurology Department, Centro Hospitalar Universitario de Coimbra, Coimbra, Portugal.
authors: Luís
authors: L
authors: Negrão
authors: Neurology Department, Centro Hospitalar do Vale do Sousa, Penafiel, Portugal.
authors: Carla
authors: C
authors: Fraga
authors: Neuropediatrics Department, Centro Materno Infantil Norte, Centro Hospitalar Porto, Porto, Portugal.
authors: Manuela
authors: M
authors: Santos
authors: Neuropediatrics Department, Hospital de Sao Joao, Porto, Portugal.
authors: Mafalda
authors: M
authors: Sampaio
authors: Instituto de Ciencias Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal.
authors: Carlos
authors: C
authors: Lopes
authors: Nuffield Department of Clinical Neurosciences, Oxford University Hospitals, University of Oxford, UK.
authors: Maria Isabel
authors: MI
authors: Leite
authors: Unit for Multidisciplinary Research in Biomedicine, Instituto de Ciencias Biomedicas de Abel Salazar, Universidade do Porto, Porto, Portugal.
authors: Guilherme
authors: G
authors: Gonçalves
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000906:Antibodies / Q000097:blood; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood / Q000453:epidemiology*; D009460:Neurologic Examination; D011174:Portugal / Q000453:epidemiology; D015995:Prevalence; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000906:Antibodies; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases
keywords: Portugal; clinical; epidemiology; incidence; laboratory; myasthenia gravis; prevalence