title: Identification of emergent bla CMY-2 -carrying Proteus mirabilis lineages by whole-genome sequencing.
abstract: Whole-genome sequencing of 24 Proteus mirabilis isolates revealed the clonal expansion of two cefoxitin-resistant strains among patients with community-onset infection. These strains harboured bla CMY-2 within a chromosomally located integrative and conjugative element and exhibited multidrug resistance phenotypes. A predominant strain, identified in 18 patients, also harboured the PGI-1 genomic island and associated resistance genes, accounting for its broader antibiotic resistance profile. The identification of these novel multidrug-resistant strains among community-onset infections suggests that they are endemic to this region and represent emergent P. mirabilis lineages of clinical significance.
authors: Department of Clinical Microbiology, Sir Patrick Dun Translational Research Laboratory, School of Medicine, Trinity College Dublin, Dublin, Ireland.
authors: M
authors: M
authors: Mac Aogáin
authors: Department of Clinical Microbiology, Sir Patrick Dun Translational Research Laboratory, School of Medicine, Trinity College Dublin, Dublin, Ireland; Department of Microbiology, St James's Hospital, Dublin, Ireland.
authors: T R
authors: TR
authors: Rogers
authors: Department of Clinical Microbiology, Sir Patrick Dun Translational Research Laboratory, School of Medicine, Trinity College Dublin, Dublin, Ireland; Department of Microbiology, St James's Hospital, Dublin, Ireland.
authors: B
authors: B
authors: Crowley
keywords: ICE; PGI-1; Proteus mirabilis; blaCMY-2; genomics