title: Monitoring efficiency of humoral rejection episode therapy in liver transplantation: any role for complement binding Luminex Single Antigen assays?
abstract: Humoral rejection and its relationship with anti HLA antibodies have been extensively studied in organ transplantation with the exception of liver transplantation (LT). Recently, association between donor specific anti HLA antibodies (DSA) and increased risk of rejection and graft loss has been suggested in LT. When such antibodies appear, adequate treatment and monitoring are needed to avoid or delay allograft loss. We report here three cases of probable antibody-mediated rejection developed after pregnancy in liver transplanted women. Sera at the time of rejection and during follow-up have been retrospectively tested for the ability of DSA to bind complement components. These cases display different outcomes depending on the complement binding DSA capacity and titers after treatment of the rejection episodes. Thus, they highlight the potential interest of complement binding Luminex Single Antigen assays to monitor the efficiency of anti-rejection therapy.
authors: Etablissement Français du Sang, Laboratoire d'Histocompatibilité, Lyon, France.
authors: Stéphanie
authors: S
authors: Ducreux
authors: Hospices civils de Lyon, Hôpital Edouard Herriot, Fédération des Spécialités Digestives, Lyon, France.
authors: Olivier
authors: O
authors: Guillaud
authors: Hospices civils de Lyon, Hôpital Edouard Herriot, Fédération des Spécialités Digestives, Lyon, France.
authors: Alexie
authors: A
authors: Bosch
authors: Hospices civils de Lyon, Hôpital Edouard Herriot, Service d'Immunologie et Transplantation, Lyon, France; Université Claude Bernard Lyon 1, Lyon, France.
authors: Olivier
authors: O
authors: Thaunat
authors: Hospices civils de Lyon, Hôpital Edouard Herriot, Service d'Immunologie et Transplantation, Lyon, France; Université Claude Bernard Lyon 1, Lyon, France.
authors: Emmanuel
authors: E
authors: Morelon
authors: Université Claude Bernard Lyon 1, Lyon, France; Hospices civils de Lyon, Hôpital Edouard Herriot, Service d'Anatomie Pathologique, Lyon, France.
authors: Valérie
authors: V
authors: Hervieu
authors: Hospices Civils de Lyon, Centre de Biologie et Pathologie Est, Laboratoire de Virologie, Lyon, France.
authors: Yahia
authors: Y
authors: Mekki
authors: Hospices civils de Lyon, Hôpital Edouard Herriot, Fédération des Spécialités Digestives, Lyon, France; Université Claude Bernard Lyon 1, Lyon, France.
authors: Olivier
authors: O
authors: Boillot
authors: Université Claude Bernard Lyon 1, Lyon, France; Hospices civils de Lyon, Hôpital Edouard Herriot, Service d'Anatomie Pathologique, Lyon, France.
authors: Jean-Yves
authors: JY
authors: Scoazec
authors: Etablissement Français du Sang, Laboratoire d'Histocompatibilité, Lyon, France.
authors: Valérie
authors: V
authors: Dubois
authors: Hospices civils de Lyon, Hôpital Edouard Herriot, Fédération des Spécialités Digestives, Lyon, France; Université Claude Bernard Lyon 1, Lyon, France.
authors: Jérôme
authors: J
authors: Dumortier
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D006084:Graft Rejection / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D056724:Immunity, Humoral; D007518:Isoantibodies / Q000097:blood*; D016031:Liver Transplantation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000188:drug therapy
chemical_list: D007518:Isoantibodies
keywords: Anti-HLA antibodies; Complement-binding antibodies; Liver transplantation; Pregnancy; Rejection; Therapy