title: Impact of hysterectomy on three-dimensional rectosigmoid morphology and endoscopy performance: a pilot study.
abstract: OBJECTIVE
  Assess differences in three-dimensional colonic metrics on CTC in women with or without hysterectomy following incomplete endoscopy to determine if there is a correlation between colonic morphology and incomplete colonoscopy after hysterectomy.
  
  
  METHODS
  Quantitative rectosigmoid metrics were derived from CTC datasets of 37 women with hysterectomy and 36 women without hysterectomy who underwent CTC for incomplete endoscopy. Evaluated metrics included colonic length, volume, tortuosity, and compactness and sigmoid apex height relative to the lumbosacral junction. Differences were measured using the Student's t test, and intra-reader reliability was assessed using ICC. The relative risk of incomplete rectosigmoid visualization was determined by reviewing the endoscopy reports.
  
  
  RESULTS
  Women with hysterectomy had a lower sigmoid apex height (p = 0.002), as well as increased tortuosity (p = 0.012) and compactness (p = 0.001) and decreased length (p = 0.026) and volume (p = 0.016) of the rectosigmoid. Intra-reader reliability was high for centerline length (ICC = 0.9940) and sigmoid apex height (ICC = 0.9851). The relative risk of incomplete visualization of the rectosigmoid on endoscopy in women with hysterectomy was 2.068 (p = 0.043) compared to women without hysterectomy.
  
  
  CONCLUSIONS
  Our pilot data show reproducible quantitative differences in three-dimensional metrics of the rectosigmoid in women with or without hysterectomy who underwent CTC for incomplete endoscopy and increased relative risk of incomplete endoscopic visualization of the rectosigmoid after hysterectomy. Our findings suggest that women with hysterectomy may benefit from CTC rather than endoscopy as the initial diagnostic test for evaluating the colon.
authors: Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
authors: Charles N
authors: CN
authors: Weber
authors: Department of Radiology, Perelman School of Medicine, Hospital of the University of Pennsylvania, 1 Silverstein Bldg., 3400 Spruce Street, Philadelphia, PA, 19104, USA.
authors: Anna S
authors: AS
authors: Lev-Toaff
authors: Department of Radiology, Perelman School of Medicine, Hospital of the University of Pennsylvania, 1 Silverstein Bldg., 3400 Spruce Street, Philadelphia, PA, 19104, USA.
authors: Marc S
authors: MS
authors: Levine
authors: Department of Radiology, Perelman School of Medicine, Hospital of the University of Pennsylvania, 1 Silverstein Bldg., 3400 Spruce Street, Philadelphia, PA, 19104, USA. hanna.zafar@uphs.upenn.edu.
authors: Hanna M
authors: HM
authors: Zafar
mesh_terms: D000368:Aged; D012809:Colon, Sigmoid / Q000000981:diagnostic imaging*; D023881:Colonography, Computed Tomographic / Q000379:methods*; D003113:Colonoscopy / Q000379:methods; D005260:Female; D006801:Humans; D007044:Hysterectomy; D021621:Imaging, Three-Dimensional; D008875:Middle Aged; D010865:Pilot Projects; D015203:Reproducibility of Results
keywords: CT colonography; Colon; Hysterectomy; Optical colonoscopy; Rectum; Sigmoid