title: Recurrent cerebral ischaemic events in the setting of paroxysmal nocturnal haemoglobinuria.
abstract: The authors present a case of a 28-year-old man with a known history of paroxysmal nocturnal haemoglobinuria (PNH), under platelet antiaggregation, admitted following recurrent transitory arterial ischaemic attacks. Concomitant thrombosis of the superior mesenteric artery and bilateral renal infarction was found. Cardioembolism, namely patent foramen ovale, was excluded and anticoagulation added, with no further events on 10-month follow-up. PNH is a rare acquired disorder of haematopoietic stem cells, characterised by haemolytic anaemia, pancytopenia and thrombotic events classically involving the venous system. Reports of cerebral artery stroke and accompanying intra-abdominal arterial thrombosis are especially rare. Complementary investigation and treatment options in these patients are discussed.
authors: Department of Neurosciences and Mental Health, Stroke Unit, Lisboa, Portugal.
authors: Luísa
authors: L
authors: Azevedo
authors: Department of Neurosciences and Mental Health, Stroke Unit, Lisboa, Portugal.
authors: Mariana Reis
authors: MR
authors: Costa
authors: Department of Neurosciences and Mental Health, Stroke Unit, Lisboa, Portugal.
authors: Ana Catarina
authors: AC
authors: Fonseca
authors: Department of Neurosciences and Mental Health, Stroke Unit, Lisboa, Portugal.
authors: Teresa
authors: T
authors: Pinho e Melo
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002545:Brain Ischemia / Q000188:drug therapy / Q000209:etiology*; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007238:Infarction / Q000150:complications; D007668:Kidney / Q000098:blood supply; D008297:Male; D017538:Mesenteric Artery, Superior; D008641:Mesenteric Vascular Occlusion / Q000150:complications*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012008:Recurrence; D013927:Thrombosis / Q000150:complications*
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors