title: Ruxolitinib: evolution or revolution in treatment of patients with polycythemia vera?
abstract: Current treatments for polycythemia vera have remained unchanged for decades with phlebotomy, hydroxycarbamide (also named hydroxyurea) and to a lesser extent interferon being the cornerstones in our therapeutic armamentarium. However, some patients do not respond to, or indeed experience significant side effects to, these current agents and development of alternative therapeutic options is required. Ruxolitinib, a potent JAK1/2 inhibitor, initially approved for myelofibrosis, was recently approved for patients with polycythemia vera refractory or intolerant to hydroxycarbamide. In this article, we review the currently available efficacy and safety data.
authors: Department of Hematology, Guy's & St Thomas' NHS Foundation Trust, London, UK.
authors: Yan
authors: Y
authors: Beauverd
authors: Department of Hematology, Guy's & St Thomas' NHS Foundation Trust, London, UK.|Department of Hematological Medicine, King's College Hospital NHS Foundation Trust, London, UK.
authors: Donal P
authors: DP
authors: McLornan
authors: Department of Hematology, Guy's & St Thomas' NHS Foundation Trust, London, UK.
authors: Deepti H
authors: DH
authors: Radia
authors: Department of Hematology, Guy's & St Thomas' NHS Foundation Trust, London, UK.
authors: Claire N
authors: CN
authors: Harrison
mesh_terms: D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D053612:Janus Kinases / Q000037:antagonists & inhibitors; D009570:Nitriles; D011087:Polycythemia Vera / Q000188:drug therapy* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011743:Pyrimidines; D016896:Treatment Outcome
chemical_list: D009570:Nitriles; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; C540383:ruxolitinib; D053612:Janus Kinases
keywords: myeloproliferative neoplasms; outcomes; polycythemia vera; ruxolitinib; treatment