title: Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism.
abstract: Inositol polyphosphate multikinase (IPMK, ipk2, Arg(82), ArgRIII) is an inositide kinase with unusually flexible substrate specificity and the capacity to partake in many functional protein-protein interactions (PPIs). By merging these two activities, IPMK is able to execute gene regulatory functions that are very unique and only now beginning to be recognized. In this short review, we present a brief history of IPMK, describe the structural biology of the enzyme and highlight a few recent discoveries that have shed more light on the role IPMK plays in inositide metabolism, nuclear signalling and transcriptional regulation.
authors: Department of Biochemistry; Vanderbilt Center for Structural Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
authors: M Merced
authors: MM
authors: Malabanan
authors: Department of Biochemistry; Vanderbilt Center for Structural Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA Department of Medicine, Vanderbilt Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA ray.blind@vanderbilt.edu).
authors: Raymond D
authors: RD
authors: Blind
mesh_terms: D000818:Animals; D055162:Biocatalysis; D002467:Cell Nucleus / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D007294:Inositol; D017853:Phosphotransferases (Alcohol Group Acceptor); C434257:inositol polyphosphate multikinase
keywords: ArgR; IPMK; gene expression; inositide; ipk2; multikinase; transcription