title: Clinicopathologic and immunohistochemical features of five new cases of solitary fibrous tumor of the oral cavity.
abstract: OBJECTIVE
  To describe the clinicopathologic and immunohistochemical features of five cases of oral solitary fibrous tumor.
  
  
  METHODS
  Clinical data were collected from charts of two oral pathology laboratories of Latin America. All cases were evaluated by conventional hematoxylin and eosin staining and an extended immunohistochemical panel comprising vimentin, CD34, CD99, bcl-2, HHF-35, smooth muscle actin, calponin, S-100 protein, h-caldesmon, and Ki-67.
  
  
  RESULTS
  The study included 1 male (20%) and 4 female (80%) patients, with a median age of 43 years. The most common affected site was the buccal mucosa (40%). Tumors were characterized by proliferation of spindled and ovoid cells in a variably vascular and collagenized stroma. All tumors were positive for vimentin, CD34, bcl-2, and CD99. Recurrence was not observed after complete surgical enucleation.
  
  
  CONCLUSIONS
  Oral solitary fibrous tumors usually appear as well-delimited submucous nodules with a firm-rubbery consistency and covered by intact mucosa. Immunoreactivity for CD34, bcl-2, and CD-99 is helpful to confirm the diagnosis.
authors: Pathology Section, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala.
authors: Román
authors: R
authors: Carlos
authors: Department of Oral Diagnosis and Pathology, Federal University of Rio de Janeiro School of Dentistry, Rio de Janeiro, Brazil.
authors: Bruno Augusto Benevenuto
authors: BA
authors: de Andrade
authors: Department of Pathology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro School of Medicine, Rio de Janeiro, Brazil.
authors: Nathalie Henriques Silva
authors: NH
authors: Canedo
authors: Department of Oral Diagnosis and Pathology, Federal University of Rio de Janeiro School of Dentistry, Rio de Janeiro, Brazil.
authors: Aline Corrêa
authors: AC
authors: Abrahão
authors: Department of Oral Diagnosis and Pathology, Federal University of Rio de Janeiro School of Dentistry, Rio de Janeiro, Brazil.
authors: Michelle
authors: M
authors: Agostini
authors: Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
authors: Oslei Paes
authors: OP
authors: de Almeida
authors: Department of Oral Diagnosis and Pathology, Federal University of Rio de Janeiro School of Dentistry, Rio de Janeiro, Brazil. Electronic address: Marioromanach@ufrj.br.
authors: Mário José
authors: MJ
authors: Romañach
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000473:pathology*; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery; D054364:Solitary Fibrous Tumors / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor