title: Lung function gain in preterm infants with and without bronchopulmonary dysplasia.
abstract: The aim of our study was to determine whether the development of lung function, during the first 2 years of life, is different in preterm infants who suffered or did not suffer from Bronchopulmonary dysplasia (BPD). We also assessed the role of nutritional status and growth in that development.
  
  
  
  Lung function tests were performed in 71 preterm infants at two time points: 6 months of corrected age and 1 year after. FVC, FEV0.5, FEF75 , and FEF25-75 were obtained from maximal expiratory volume curves by means of the raised volume rapid thoraco-abdominal compression technique.
  
  
  
  When comparing lung function measurements, we found that FVC (P = 0.033) FEV0.5 (P = 0.044), FEF75 (P = 0.014), and FEF25-75 (P = 0.036) were significantly lower in BPD infants. We did not find any catch-up of lung function during the study time, in neither the whole group of children nor within the BPD or non-BPD groups. The increase in lung function was directly proportional to the increase in weight and length. The multivariate analysis showed that the increase in z-score of FVC (P = 0.043), FEV0.5 (P = 0.015), and FEF75 (P = 0.042), was related with the height velocity during the study period.
  
  
  
  Infants who suffered from BPD have lower lung function (FVC, FEV0.5 , FEF75 , and FEF25-75 ), than those non-BPD, at two different time points 1 year apart. During the study period, there was no lung function catch-up in either BPD or non-BPD infants. The increase in length is closely associated to the increase in lung function. Pediatr Pulmonol. 2016; 51:936-942. © 2016 Wiley Periodicals, Inc.
authors: Department of Pediatrics, University of Murcia, Murcia, Spain.|Department of Pediatrics, Virgen de la Arrixaca University Hospital, Murcia, Spain.|IMIB Bio-research Institute, Murcia, Spain.
authors: Manuel
authors: M
authors: Sanchez-Solis
authors: Department of Pediatrics, University of Murcia, Murcia, Spain.|Department of Pediatrics, Virgen de la Arrixaca University Hospital, Murcia, Spain.
authors: Virginia
authors: V
authors: Perez-Fernandez
authors: Department of Pediatrics, University of Murcia, Murcia, Spain.|Department of Pediatrics, Virgen de la Arrixaca University Hospital, Murcia, Spain.|IMIB Bio-research Institute, Murcia, Spain.
authors: Vicente
authors: V
authors: Bosch-Gimenez
authors: Department of Pediatrics, Virgen de la Arrixaca University Hospital, Murcia, Spain.
authors: Juan J
authors: JJ
authors: Quesada
authors: Department of Pediatrics, University of Murcia, Murcia, Spain.|Department of Pediatrics, Virgen de la Arrixaca University Hospital, Murcia, Spain.|IMIB Bio-research Institute, Murcia, Spain.
authors: Luis
authors: L
authors: Garcia-Marcos
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008168:Lung / Q000502:physiology* / Q000503:physiopathology*; D008297:Male; D015999:Multivariate Analysis; D009752:Nutritional Status; D012129:Respiratory Function Tests
keywords: Bronchopulmonary dysplasia; infant lung function; preterm newborn