title: Carbohydrate Deficient Transferrin and Interleukin-6 as Predictors of Fibrosis in Alcohol Cirrhosis.
abstract: The severity of alcoholic cirrhosis depends on the presence of liver inflammation and fibrogenesis. Previous studies have hypothesized that carbohydrate deficient transferrin can be used as marker of liver impairment in alcoholic liver disease patients. The present study was designed to assess whether carbohydrate deficient transferrin is associated with procollagen III peptide and predict fibrosis in alcohol cirrhosis patients. We enrolled 48 patients with alcoholic cirrhosis and 38 healthy controls. Serum carbohydrate deficient transferrin, procollagen III peptide and interleukin-6 levels were estimated in both groups. Serum carbohydrate deficient transferrin, procollagen III peptide and interleukin-6 were significantly increased in alcoholic cirrhosis patients compared to controls. Stepwise regression analysis showed that carbohydrate deficient transferrin (adjusted R(2) = 0.313, β = 0.362, p = 0.003) and interleukin-6 (adjusted R(2) = 0.194, β = 0.459, p = 0.001) were positively associated with procollagen III peptide when age, duration and amount of alcohol consumption were considered as covariates. We conclude that elevated carbohydrate deficient transferrin and interleukin-6 act as predictors of fibrosis in alcoholic cirrhosis.
authors: Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
authors: Hanumanthappa
authors: H
authors: Nandeesha
authors: Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
authors: Medha
authors: M
authors: Rajappa
authors: Department of Medicine, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
authors: Tamilarasu
authors: T
authors: Kadhiravan
authors: Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
authors: Krishnamoorthy
authors: K
authors: Srilatha
authors: Department of Medical Biometrics and Informatics, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
authors: Kottyen Thazhath
authors: KT
authors: Harichandrakumar
authors: Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
authors: Durgadevi
authors: D
authors: Thyagarajan
keywords: Carbohydrate deficient transferrin; Fibrogenesis; Inflammation; Interleukin-6; Procollagen III peptide