title: Unilateral uveitis masquerade syndrome caused by diffuse large B-cell lymphoma diagnosed using multiparametric flow cytometry of the aqueous humor.
abstract: The uveitis masquerade syndromes (UMS) are a group of ocular diseases that may mimic chronic intraocular inflammation. Many malignant entities such as non-Hodgkin's lymphomas may masquerade as uveitis. We report a case of an HIV-positive patient with masquerade syndrome presenting unilateral uveitis.
  
  
  
  45-year-old Caucasian man with a diagnosis of diffuse large B-cell lymphoma (DLBCL). The patient was diagnosed by a biopsy of an abdominal mass which showed fragments of gastric mucosa with diffuse growth of neoplastic cells. At diagnosis, the patient suffered from unilateral blurring of vision and a sudden decrease of left-eye visual acuity. A slit-lamp examination of the left eye revealed a diagnosis of anterior uveitis. The patient exhibited no signs of posterior uveitis. An anterior-chamber paracentesis was performed and analyzed by multiparameter flow cytometry (MFC), showing cells CD45, CD19, CD20, CD22, and CD38 positives, and moderate expression of CD10 with kappa light chain restriction, showing a monoclonal B-cell population. The patient received CHOP-R with intrathecal methotrexate followed by consolidation high dose methotrexate obtaining a complete response which is ongoing.
  
  
  
  Differential diagnosis between chronic uveitis and ocular lymphoma may be challenging. We advocate anterior-chamber paracentesis in cases of refractory uveitis in patients with hematologic malignancies. © 2016 International Clinical Cytometry Society.
authors: Lymphoma Unit, Department of Hematology, Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
authors: Silvia
authors: S
authors: Monsalvo
authors: Lymphoma Unit, Department of Hematology, Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
authors: Cristina
authors: C
authors: Serrano
authors: Lymphoma Unit, Department of Hematology, Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
authors: Elena
authors: E
authors: Prieto
authors: Department of Ophthalmology, Fundacion Jimenez Diaz University Hospital, Madrid, Spain.
authors: Guillermo
authors: G
authors: Fernández-Sanz
authors: Department of Pathology, Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
authors: Maria-Camino
authors: MC
authors: Puente
authors: Department of Pathology, Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
authors: Maria
authors: M
authors: Rodriguez-Pinilla
authors: Lymphoma Unit, Department of Hematology, Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
authors: Aranzazu
authors: A
authors: Garcia Raso
authors: Lymphoma Unit, Department of Hematology, Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
authors: Pilar
authors: P
authors: Llamas
authors: Lymphoma Unit, Department of Hematology, Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
authors: Raul
authors: R
authors: Cordoba
mesh_terms: D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000187:drug effects / Q000276:immunology; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005434:Flow Cytometry / Q000379:methods; D015870:Gene Expression; D006801:Humans; D007249:Inflammation; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D019152:Paracentesis; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome; D014602:Uvea / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D014605:Uveitis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate
keywords: Unilateral uveitis masquerade syndrome; diffuse large B-cell lymphoma; multiparametric flow cytometry