title: Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension.
abstract: The continuous changes in pulmonary hemodynamic properties in hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PoPH) have not been fully characterized in large animal models of HPS and PoPH. Beagle dog models of HPS and PoPH were induced by chronic common bile duct ligation and Sephadex microspheres, respectively. The model was validated by catheter examination and pathological analyses, and the hemodynamic characteristics of the models were observed. The results revealed that the cross-sectional area of the blood vessel was significantly increased in HPS models, but it was significantly decreased in the PoPH models. Furthermore, the resistance of pulmonary circulation was elevated in models of HPS, but it was decreased in models of PoPH. The present findings renew the traditional view that pulmonary hypertension is due to the enhanced peripheral resistance.
authors: Department of Ultrasound, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014010, P.R. China.
authors: Guozhen
authors: G
authors: Yan
authors: Department of Ultrasound, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014010, P.R. China.
authors: Junfeng
authors: J
authors: He
authors: Department of Ultrasound, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014010, P.R. China.
authors: Yueli
authors: Y
authors: Yu
authors: Department of Ultrasound, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014010, P.R. China.
authors: Yang
authors: Y
authors: Liu
authors: Department of Ultrasound, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014010, P.R. China.
authors: Yanfen
authors: Y
authors: Yuan
authors: Department of Ultrasound, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014010, P.R. China.
authors: Zhiyong
authors: Z
authors: Guo
keywords: beagle dog; hemodynamic characteristics; hepatopulmonary syndrome; portopulmonary hypertension