title: To Cut or Not to Cut: Discovery of a Novel Regulator of DNA Break Resection.
abstract: Nucleolytic resection of DNA double-strand breaks is the crucial first step in their repair via homologous recombination. New findings by Tkáč et al. (2016) published in this issue of Molecular Cell identify HELB as a novel, cell-cycle-specific negative regulator of DNA end resection.
authors: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: james.daley@yale.edu.
authors: James M
authors: JM
authors: Daley
authors: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA.
authors: Patrick
authors: P
authors: Sung
mesh_terms: D000818:Animals; D059766:DNA End-Joining Repair; D004265:DNA Helicases / Q000378:metabolism*; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology*
chemical_list: D004265:DNA Helicases