title: Diffuse Large B-Cell Lymphoma Version 1.2016.
abstract: Diffuse large B-cell lymphomas (DLBCL) are now considered a heterogeneous group of distinct molecular subtypes (germinal center B-cell DLBCL, activated B-cell DLBCL, and primary mediastinal large B-cell lymphoma (PMBL) with varied natural history and response to therapy. In addition, a subset of patients with DLBCL have concurrent MYC and/or BCL2 gene rearrangements (double-hit lymphomas; DHL) and others have a dual expression of both MYC and BCL2 proteins (double-expressing DLBCL; DEL). The standard of care for the treatment of patients with PMBL, DHL, or DEL has not been established. Adequate immunophenotyping and molecular testing (in selected circumstances) are necessary for the accurate diagnosis of different subtypes of DLBCL. The NCCN Guidelines included in this issue, part of the NCCN Guidelines for non-Hodgkin's lymphomas, address the diagnosis and management of DLBCL and its subtypes.
authors: Andrew D
authors: AD
authors: Zelenetz
authors: Leo I
authors: LI
authors: Gordon
authors: William G
authors: WG
authors: Wierda
authors: Jeremy S
authors: JS
authors: Abramson
authors: Ranjana H
authors: RH
authors: Advani
authors: C Babis
authors: CB
authors: Andreadis
authors: Nancy
authors: N
authors: Bartlett
authors: John C
authors: JC
authors: Byrd
authors: Luis E
authors: LE
authors: Fayad
authors: Richard I
authors: RI
authors: Fisher
authors: Martha J
authors: MJ
authors: Glenn
authors: Thomas M
authors: TM
authors: Habermann
authors: Nancy
authors: N
authors: Lee Harris
authors: Francisco
authors: F
authors: Hernandez-Ilizaliturri
authors: Richard T
authors: RT
authors: Hoppe
authors: Steven M
authors: SM
authors: Horwitz
authors: Mark S
authors: MS
authors: Kaminski
authors: Christopher R
authors: CR
authors: Kelsey
authors: Youn H
authors: YH
authors: Kim
authors: Susan
authors: S
authors: Krivacic
authors: Ann S
authors: AS
authors: LaCasce
authors: Matthew
authors: M
authors: Lunning
authors: Auayporn
authors: A
authors: Nademanee
authors: Pierluigi
authors: P
authors: Porcu
authors: Oliver
authors: O
authors: Press
authors: Rachel
authors: R
authors: Rabinovitch
authors: Nishitha
authors: N
authors: Reddy
authors: Erin
authors: E
authors: Reid
authors: Kenneth
authors: K
authors: Roberts
authors: Ayman A
authors: AA
authors: Saad
authors: Lubomir
authors: L
authors: Sokol
authors: Lode J
authors: LJ
authors: Swinnen
authors: Julie M
authors: JM
authors: Vose
authors: Joachim
authors: J
authors: Yahalom
authors: Nadeem
authors: N
authors: Zafar
authors: Mary
authors: M
authors: Dwyer
authors: Hema
authors: H
authors: Sundar
mesh_terms: D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy* / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc