title: Soft Computing Techniques for the Protein Folding Problem on High Performance Computing Architectures.
abstract: The protein-folding problem has been extensively studied during the last fifty years. The understanding of the dynamics of global shape of a protein and the influence on its biological function can help us to discover new and more effective drugs to deal with diseases of pharmacological relevance. Different computational approaches have been developed by different researchers in order to foresee the threedimensional arrangement of atoms of proteins from their sequences. However, the computational complexity of this problem makes mandatory the search for new models, novel algorithmic strategies and hardware platforms that provide solutions in a reasonable time frame. We present in this revision work the past and last tendencies regarding protein folding simulations from both perspectives; hardware and software. Of particular interest to us are both the use of inexact solutions to this computationally hard problem as well as which hardware platforms have been used for running this kind of Soft Computing techniques.
authors: Antonio
authors: A
authors: Llanes
authors: Andrés
authors: A
authors: Muñoz
authors: Andrés
authors: A
authors: Bueno-Crespo
authors: Teresa
authors: T
authors: García-Valverde
authors: Antonia
authors: A
authors: Sánchez
authors: Francisco
authors: F
authors: Arcas-Túnez
authors: Horacio
authors: H
authors: Pérez-Sánchez
authors: Computer Science Department, Bioinformatics and High Performance Computing Research Group (BIOHPC), Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, s/n Guadalupe 30107 (Murcia), Spain.
authors: José M
authors: JM
authors: Cecilia
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D012984:Software
chemical_list: D011506:Proteins