title: Imaging genomics in cancer research: limitations and promises.
abstract: Recently, radiogenomics or imaging genomics has emerged as a novel high-throughput method of associating imaging features with genomic data. Radiogenomics has the potential to provide comprehensive intratumour, intertumour and peritumour information non-invasively. This review article summarizes the current state of radiogenomic research in tumour characterization, discusses some of its limitations and promises and projects its future directions. Semi-radiogenomic studies that relate specific gene expressions to imaging features will also be briefly reviewed.
authors: 1 Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
authors: Harrison X
authors: HX
authors: Bai
authors: 1 Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
authors: Ashley M
authors: AM
authors: Lee
authors: 2 Department of Neurology, The Second Xiangya Hospital, Changsha, Hunan, China.
authors: Li
authors: L
authors: Yang
authors: 3 Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
authors: Paul
authors: P
authors: Zhang
authors: 1 Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
authors: Christos
authors: C
authors: Davatzikos
authors: 4 Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.|5 Abramson Family Cancer Research Institute, PerelmanSchool of Medicine, University of Pennsylvania, Philadelphia, PA, USA.|6 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors: John M
authors: JM
authors: Maris
authors: 4 Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.|5 Abramson Family Cancer Research Institute, PerelmanSchool of Medicine, University of Pennsylvania, Philadelphia, PA, USA.|6 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors: Sharon J
authors: SJ
authors: Diskin
mesh_terms: D003952:Diagnostic Imaging; D023281:Genomics; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics*