title: Taurine Attenuates Dimethylbenz[a]anthracene-induced Breast Tumorigenesis in Rats: A Plasma Metabolomic Study.
abstract: Breast cancer is the most common malignancy and the leading cause of cancer-related mortality in women worldwide. Taurine, the most abundant free amino acid, plays a role in several biological processes in humans and has been shown to have activity against breast cancer and other tumors. To investigate the role and mechanism of taurine action in breast cancer, we used dimethylbenz[a]anthracene (DMBA)-induced breast carcinogenesis in rats as a model of breast cancer. The administration of taurine significantly reduced the DMBA-induced breast cancer rate from 80% to 40% in rats (p<0.05). Metabolomic studies using time-of-flight gas chromatography-mass spectrometry identified 23 differential metabolites in the plasma of taurine-administered rats. Bioinformatic analysis further revealed that these metabolites are involved in multiple metabolic pathways, including energy, glucose, amino acid, and nucleic acid metabolism, suggesting that the antitumor activity of taurine in rats is mediated through altered metabolism of breast cancer cells. We propose that these differential metabolites may be potential biomarkers for monitoring cancer therapy and prognosis in the clinic. This study provides a scientific basis for further investigations of the antitumor mechanism of taurine and the development of novel therapeutic strategies to treat breast cancer.
authors: Department of Nutrition, First Affiliated Hospital of Guangxi Medical University, Nanning, P.R. China.
authors: Y U
authors: YU
authors: He
authors: Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A.
authors: Qingdi Quentin
authors: QQ
authors: Li
authors: Guangxi Medical University School of Public Health, Nanning, P.R. China 2433164518@qq.com.
authors: Song Chao
authors: SC
authors: Guo
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D055432:Metabolomics; D010949:Plasma / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000494:pharmacology*
chemical_list: D002273:Carcinogens; D013654:Taurine; D015127:9,10-Dimethyl-1,2-benzanthracene
keywords: Taurine; Warburg effect; breast cancer; metabolic alteration; metabolomics; rat animal model