title: Relationship of cumulative dust exposure dose and cumulative abnormal rate of pulmonary function in coal mixture workers.
abstract: To investigate the dose-response relationship between cumulative dust exposure (CDE) and cumulative abnormal rate of pulmonary function in coal mixture workers. Three hundred and twenty eight coal mixture workers (exposed group) and 169 nondust-exposed workers (control group) were recruited. Basic information data were collected and pulmonary function tests were performed. Pulmonary function was compared between the two groups after comparing smoking behaviors. Pulmonary function indices [forced vital capacity in 1 second after full inspiration (FVC)%, forced expiratory volume (FEV)1%, and FEV1/FVC%] were compared among groups stratified by service length (exposure duration). The relationship between CDE dose and cumulative abnormal rate of pulmonary function in coal mixture workers was analyzed. Abnormal rate of pulmonary function in the exposed group (35.1%) was significantly higher than the control group (10.1%; p < 0.001); FVC%, FEV1%, and FEV1/FVC% in the exposed group decreased significantly compared with the control group (all p < 0.05). Differences in FVC%, FEV1%, and FEV1/FVC% among coal mixture workers stratified by exposure duration in the exposed group were statistically significant (all p < 0.05). The discernible increase in the cumulative abnormal rate was observed, from ≥ 1000 mg/m(3)·years group to ≥ 1700 mg/m(3)·years group. Correlation analysis revealed a positive correlation between the CDE dose and the cumulative abnormal rate of pulmonary function. Higher abnormal pulmonary function rate was found among coal mixture workers, characterized by decreased pulmonary function indices. Our results suggested a positive relationship between CDE dose and cumulative abnormal pulmonary function rate, and a rapid increase in cumulative abnormal rate within a certain range of CDE dose. A lower limit value of 1000 mg/m(3)·years has reference significance.
authors: College of Public Health, North China University of Science and Technology, Tangshan, People's Republic of China.
authors: Qing-Zeng
authors: QZ
authors: Qian
authors: College of Life Science, North China University of Science and Technology, Tangshan, People's Republic of China.
authors: Xiang-Ke
authors: XK
authors: Cao
authors: Affiliated Hospital of North China University of Science and Technology, Tangshan, People's Republic of China.
authors: Qing-Qiang
authors: QQ
authors: Qian
authors: College of Public Health, North China University of Science and Technology, Tangshan, People's Republic of China. Electronic address: shenfuhai_0727@163.com.
authors: Fu-Hai
authors: FH
authors: Shen
authors: College of Public Health, North China University of Science and Technology, Tangshan, People's Republic of China.
authors: Qian
authors: Q
authors: Wang
authors: College of Public Health, North China University of Science and Technology, Tangshan, People's Republic of China.
authors: Hai-Yan
authors: HY
authors: Liu
authors: College of Public Health, North China University of Science and Technology, Tangshan, People's Republic of China.
authors: Jun-Wang
authors: JW
authors: Tong
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity; D055008:Anthracosis / Q000503:physiopathology*; D060729:Coal Ash / Q000633:toxicity; D004391:Dust; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008875:Middle Aged; D000067572:Miners; D009784:Occupational Diseases / Q000503:physiopathology*; D016273:Occupational Exposure; D014797:Vital Capacity; D055815:Young Adult
chemical_list: D000395:Air Pollutants, Occupational; D060729:Coal Ash; D004391:Dust
keywords: Coal mixture workers; Cumulative abnormal rate; Cumulative dust exposure; Pulmonary function; Pulmonary function indices