title: Epidemiologic Study of Charcot-Marie-Tooth Disease: A Systematic Review.
abstract: BACKGROUND
  Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy. CMT is classified into 2 main subgroups: CMT type 1 (CMT1; demyelinating form) and CMT type 2 (CMT2; axonal form). The objectives of this study were to systematically review and assess the quality of studies reporting the incidence and/or prevalence of CMT worldwide.
  
  
  CONCLUSIONS
  A total of 802 studies were initially identified, with only 12 meeting the inclusion criteria. CMT prevalence was reported in 10 studies and ranged from 9.7/100,000 in Serbia to 82.3/100,000 in Norway. The frequency of the main subtypes varied from 37.6 to 84% for CMT1 and from 12 to 35.9% for CMT2; the country with the lowest prevalence of CMT1 was Norway, and the country with the highest prevalence of CMT1 was Iceland; on the other hand, CMT2 was least prevalent in the United Kingdom and most prevalent in Norway.
  
  
  CONCLUSIONS
  This review reveals the gaps that still exist in the epidemiological knowledge of CMT around the world. Published studies are of varying quality and utilise different methodologies, thus precluding a robust conclusion. Additional research focusing on epidemiological features of CMT in different nations and different ethnic groups is needed.
authors: Nx00FA;cleo de Px00F3;s-Graduax00E7;x00E3;o em Medicina da Universidade Federal de Sergipe (UFS), Rua Clx00E1;udio Batista S/N Bairro Sanatx00F3;rio, Aracaju, SE, Brazil.
authors: Lidiane Carine Lima Santos
authors: LC
authors: Barreto
authors: Fernanda Santos
authors: FS
authors: Oliveira
authors: Paula Santos
authors: PS
authors: Nunes
authors: Iandra Maria Pinheiro
authors: IM
authors: de França Costa
authors: Catarina Andrade
authors: CA
authors: Garcez
authors: Gabriel Mattos
authors: GM
authors: Goes
authors: Eduardo Luis Aquino
authors: EL
authors: Neves
authors: Jullyana
authors: J
authors: de Souza Siqueira Quintans
authors: Adriano Antunes
authors: AA
authors: de Souza Araújo
mesh_terms: D002607:Charcot-Marie-Tooth Disease / Q000175:diagnosis* / Q000453:epidemiology*; D016021:Epidemiologic Studies; D006801:Humans; D011159:Population Surveillance / Q000379:methods