title: Dietary consumption of advanced glycation end products and risk of metabolic syndrome.
abstract: Metabolic syndrome (MetS) is a complex disorder which has become one of the major public health challenges worldwide. This study was conducted to evaluate the association between dietary advanced glycation end products (AGEs) and risk of MetS and its components. This cross-sectional study was conducted in a representative sample of 5848 adults, aged 19-70 years. Daily consumption of carboxymethyl lysine, a major type of AGEs, was determined using a validated semi-quantitative food frequency questionnaire. Across increasing trend of AGEs consumption, the percentage of fat intake increased and that of carbohydrate significantly decreased (p < 0.001). Subjects in the highest (>10,506 kU/d) compared to the lowest (<6673 kU/d) quartile category of AGEs had higher risk of abdominal obesity (OR: 1.19, 95% CI: 1.01-1.39) and hypertriglyceridemia (OR: 1.26, 95% CI: 1.07-1.49). Therefore, recommendation on restriction of AGEs intake could be a practical approach to prevent metabolic abnormalities.
authors: a Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran ;
authors: Pooneh
authors: P
authors: Angoorani
authors: b Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences , Tehran , Iran ;|c Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences , Tehran , Iran ;
authors: Hanieh-Sadat
authors: HS
authors: Ejtahed
authors: a Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran ;|d Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology , National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences , Tehran , Iran ;
authors: Parvin
authors: P
authors: Mirmiran
authors: a Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran ;
authors: Sahar
authors: S
authors: Mirzaei
authors: e Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors: Fereidoun
authors: F
authors: Azizi
mesh_terms: D000328:Adult; D000368:Aged; D003625:Data Collection; D004034:Diet Surveys; D005247:Feeding Behavior; D005260:Female; D017127:Glycation End Products, Advanced / Q000009:adverse effects*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000209:etiology; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D017127:Glycation End Products, Advanced
keywords: Abdominal obesity; dietary AGEs; hypertriglyceridemia; metabolic syndrome; obesity