title: Antibiotic-eluting hydrophilized PMMA bone cement with prolonged bactericidal effect for the treatment of osteomyelitis.
abstract: Osteomyelitis is still considered to be one of the major challenges for orthopedic surgeons despite advanced antiseptic surgical procedures and pharmaceutical therapeutics. In this study, hydrophilized poly(methyl methacrylate) (PMMA) bone cements containing Pluronic F68 (EG79PG28EG79) as a hydrophilic additive and vancomycin (F68-VAcements) were prepared to allow the sustained release of the antibiotic for adequate periods of time without any significant loss of mechanical properties. The compressive strengths of the bone cements with Pluronic F68 compositions less than 7 wt% were not significantly different compared with the control vancomycin-loaded bone cement (VAcement). TheF68 (7 wt%)-VAcement showed sustained release of the antibiotic for up to 11 weeks and almost 100% release from the bone cement. It also prohibited the growth ofS. aureus(zone of inhibition) over six weeks (the required period to treat osteomyelitis), and it did not show any notable cytotoxicity. From an animal study using a femoral osteomyelitis rat model, it was observed that theF68 (7 wt%)-VAcement was effective for the treatment of osteomyelitis, probably as a result of the prolonged release of antibiotic from the PMMA bone cement. On the basis of these findings, it can be suggested that the use of Pluronic F68 as a hydrophilic additive for antibiotic-eluting PMMA bone cement can be a promising strategy for the treatment of osteomyelitis.
authors: Department of Advanced Materials, Hannam University, Daejeon, Republic of Korea.
authors: Eun Jo
authors: EJ
authors: Oh
authors: Department of Nanobiomedical Science, Dankook University, Cheonan, Republic of Korea.
authors: Se Heang
authors: SH
authors: Oh
authors: Department of Biotechnology, Hannam University, Daejeon, Republic of Korea.
authors: In Soo
authors: IS
authors: Lee
authors: Department of Orthopedics, Catholic University Hospital, Daejeon, Republic of Korea.
authors: Oh Soo
authors: OS
authors: Kwon
authors: Department of Advanced Materials, Hannam University, Daejeon, Republic of Korea jhlee@hnu.kr.
authors: Jin Ho
authors: JH
authors: Lee
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001843:Bone Cements / Q000737:chemistry*; D019245:Compressive Strength; D003692:Delayed-Action Preparations / Q000737:chemistry*; D008422:Materials Testing; D010019:Osteomyelitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D014640:Vancomycin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D003692:Delayed-Action Preparations; D014640:Vancomycin; D019904:Polymethyl Methacrylate
keywords: Osteomyelitis; PMMA bone cement; amphiphilic additive; antibiotic; local delivery