title: Polyvinylpyrrolidone-Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine.
abstract: One of the biggest obstacles for the development of HIV vaccines is how to sufficiently trigger crucial anti-HIV immunities via a safe manner. We herein integrated surface modification-dependent immunostimulation against HIV vaccine and shape-dependent biosafety and designed a safe noncarrier adjuvant based on silver nanorods coated by both polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG). Such silver nanorods can significantly elevate crucial immunities of HIV vaccine and overcome the toxicity, which is a big problem for other existing adjuvants. This study thus provided a principle for designing a safe and high-efficacy material for an adjuvant and allow researchers to really have a safe and effective prophylaxis against HIV. We expect this material approach to be applicable to other types of vaccines, whether they are preventative or therapeutic.
authors: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology , Number 11 Zhongguancun Beiyitiao, Beijing 100190, China.
authors: Ye
authors: Y
authors: Liu
authors: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology , Number 11 Zhongguancun Beiyitiao, Beijing 100190, China.
authors: Yekkuni L
authors: YL
authors: Balachandran
authors: State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing 100190, China.
authors: Dan
authors: D
authors: Li
authors: State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing 100190, China.|Center of Infectious Diseases, Peking University , Beijing 100190, China.|Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Hangzhou 310027, China.|School of Medicine, Nankai University , Tianjin 300071, China.
authors: Yiming
authors: Y
authors: Shao
authors: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology , Number 11 Zhongguancun Beiyitiao, Beijing 100190, China.
authors: Xingyu
authors: X
authors: Jiang
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control*; D015497:HIV-1 / Q000276:immunology; D006367:HeLa Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008807:Mice, Inbred BALB C; D043942:Nanotubes / Q000737:chemistry / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry / Q000627:therapeutic use*; D011205:Povidone / Q000737:chemistry / Q000627:therapeutic use*; D012834:Silver / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D016915:AIDS Vaccines; D000276:Adjuvants, Immunologic; D004337:Drug Carriers; D012834:Silver; D011092:Polyethylene Glycols; D011205:Povidone
keywords: HIV vaccine; immune response; noncarrier adjuvant; poly(ethylene glycol); polyvinylpyrrolidone; silver nanorod