title: Targeting plasma cells: are we any closer to a panacea for diseases of antibody-secreting cells?
abstract: Antibody-secreting cells (ASCs) are critical for a functional and effective adaptive immune system. In a number of illnesses, however, these same cells contribute to the underlying disease state leading to significant morbidity and mortality. While therapeutic targeting of antibody-secreting cells has progressed significantly over the last two decades, many of these conditions remain major health problems. In this review, we will discuss current and potential therapeutic targeting of ASCs in the context of the known biology of these cells.
authors: Immunology Division, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Vic., Australia.|Department of Haematology, Monash Health, Monash Hospital, Clayton, Vic., Australia.|Department of Medical Biology, The University of Melbourne, Parkville, Vic., Australia.
authors: Michael
authors: M
authors: Low
authors: Immunology Division, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Vic., Australia.|Department of Medical Biology, The University of Melbourne, Parkville, Vic., Australia.
authors: Simona
authors: S
authors: Infantino
authors: Department of Haematology, Monash Health, Monash Hospital, Clayton, Vic., Australia.|School of Clinical Sciences at Monash Health, Monash University, Clayton, Vic., Australia.|Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Vic., Australia.|Malignant Haematology and Stem Cell Transplantation Service and Alfred Pathology Service, The Alfred, Melbourne, Vic., Australia.
authors: George
authors: G
authors: Grigoriadis
authors: Immunology Division, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Vic., Australia.|Department of Haematology, Monash Health, Monash Hospital, Clayton, Vic., Australia.
authors: David
authors: D
authors: Tarlinton
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D002470:Cell Survival / Q000235:genetics / Q000276:immunology; D004198:Disease Susceptibility; D005786:Gene Expression Regulation; D006801:Humans; D058990:Molecular Targeted Therapy; D010641:Phenotype; D010950:Plasma Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D014158:Transcription, Genetic
keywords: antibody-secreting cells; plasma cells; therapeutics