title: Putamen volume correlates with obsessive compulsive characteristics in healthy population.
abstract: Obsessions and compulsions (OCs) are frequent in healthy subjects; however neural backgrounds of the subclinical OCs were largely unknown. Results from recent studies suggested involvement of the putamen in the OC traits. To investigate this issue, 49 healthy subjects were assessed using structural magnetic resonance imaging (MRI) and the Maudsley Obsessive Compulsive Inventory (MOCI). Anatomical delineation on MRI yielded the global volume and local shape of the putamen. Other striatal structures (the caudate nucleus and globus pallidus) were also examined for exploratory purpose. The relationship between volume/shape of each structures and MOCI measure was analyzed, with sex, age, state anxiety, trait anxiety, and full-scale Intelligence Quotient regressed out. The volume analysis revealed a positive relationship between the MOCI total score and the bilateral putamen volumes. The shape analysis demonstrated associations between the higher MOCI total score and hypertrophy of the anterior putamen in both hemispheres. The present study firstly revealed that the volume changes of the putamen correlated with the manifestation of subclinical OC traits. The dysfunctional cortico-anterior striatum networks seemed to be one of the neuronal subsystems underlying the subclinical OC traits.
authors: Health and Medical Services Center, Shiga University, Shiga, Japan. Electronic address: yka@edu.shiga-u.ac.jp.
authors: Yasutaka
authors: Y
authors: Kubota
authors: The Organization for Promoting Developmental Disorder Research, Kyoto, Japan; The Hakubi Project, Primate Research Institute, Kyoto University, Aichi, Japan.
authors: Wataru
authors: W
authors: Sato
authors: The Hakubi Project, Primate Research Institute, Kyoto University, Aichi, Japan.
authors: Takanori
authors: T
authors: Kochiyama
authors: Faculty of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Shota
authors: S
authors: Uono
authors: Faculty of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Sayaka
authors: S
authors: Yoshimura
authors: The Hakubi Project, Primate Research Institute, Kyoto University, Aichi, Japan.
authors: Reiko
authors: R
authors: Sawada
authors: Rakuwa-kai Otowa Hospital, Kyoto, Japan.
authors: Morimitsu
authors: M
authors: Sakihama
authors: The Organization for Promoting Developmental Disorder Research, Kyoto, Japan; Faculty of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Motomi
authors: M
authors: Toichi
mesh_terms: D000328:Adult; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000473:pathology; D003192:Compulsive Behavior / Q000000981:diagnostic imaging / Q000473:pathology*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005917:Globus Pallidus / Q000000981:diagnostic imaging / Q000473:pathology; D064368:Healthy Volunteers / Q000523:psychology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009770:Obsessive Behavior / Q000000981:diagnostic imaging / Q000473:pathology*; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging / Q000473:pathology; D011699:Putamen / Q000000981:diagnostic imaging / Q000473:pathology*; D012044:Regression Analysis; D055815:Young Adult
keywords: Compulsions; MRI; Obsessions; Putamen; Striatum; Volumetry