title: Lanthanides: Applications in Cancer Diagnosis and Therapy.
abstract: Lanthanide complexes are of increasing importance in cancer diagnosis and therapy, owing to the versatile chemical and magnetic properties of the lanthanide-ion 4f electronic configuration. Following the first implementation of gadolinium(III)-based contrast agents in magnetic resonance imaging in the 1980s, lanthanide-based small molecules and nanomaterials have been investigated as cytotoxic agents and inhibitors, in photodynamic therapy, radiation therapy, drug/gene delivery, biosensing, and bioimaging. As the potential utility of lanthanides in these areas continues to increase, this timely review of current applications will be useful to medicinal chemists and other investigators interested in the latest developments and trends in this emerging field.
authors: Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.
authors: Ruijie D
authors: RD
authors: Teo
authors: Department of Molecular Medicine, Beckman Research Institute of the City of Hope , 1500 E. Duarte Road, Duarte, California 91010, United States.
authors: John
authors: J
authors: Termini
authors: Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.
authors: Harry B
authors: HB
authors: Gray
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods; D003287:Contrast Media / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D056831:Coordination Complexes / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods; D018014:Gene Transfer Techniques; D006801:Humans; D028581:Lanthanoid Series Elements / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D061848:Optical Imaging / Q000379:methods; D010778:Photochemotherapy / Q000379:methods; D011878:Radiotherapy / Q000379:methods
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D028581:Lanthanoid Series Elements