title: Role of bentonite clays on cell growth.
abstract: Bentonites, naturally occurring clays, are produced industrially because of their adsorbent capacity but little is known about their effects on human health. This manuscript reports on the effect of bentonites on cell growth behaviour. Bentonites collected from India (Bent-India), Hungary (Bent-Hungary), Argentina (Bent-Argentina), and Indonesia (Bent-Indonesia) were studied. All four bentonites were screened in-vitro against two human cancer cell lines [U251 (central nervous system, glioblastoma) and SKLU-1 (lung adenocarcinoma)] supplied by the National Cancer Institute (USA). Bentonites induced growth inhibition in the presence of U251 cells, and growth increment in the presence of SKLU-1 cells, showing that interactions between bentonite and cell surfaces were highly specific. The proliferation response for U251 cells was explained because clay surfaces controlled the levels of metabolic growth components, thereby inhibiting the development of high-grade gliomas, particularly primary glioblastomas. On the other hand, the proliferation response for SKLU-1 was explained by an exacerbated growth favoured by swelling, and concomitant accumulation of solutes, and their hydration and transformation via clay-surface mediated reactions.
authors: Departamento de Procesos y Tecnología, Universidad Autónoma Metropolitana, México; Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA; NASA Astrobiology Institute, USA. Electronic address: jcervini@correo.cua.uam.mx.
authors: Javiera
authors: J
authors: Cervini-Silva
authors: Laboratorio de Pruebas Biológicas, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria México City, México.
authors: María Teresa
authors: MT
authors: Ramírez-Apan
authors: BGR Bundesansaltfür Geowissenschaften und Rohstoffe, Stilleweg 2, D-30655 Hannover, Germany.
authors: Stephan
authors: S
authors: Kaufhold
authors: BGR Bundesansaltfür Geowissenschaften und Rohstoffe, Stilleweg 2, D-30655 Hannover, Germany.
authors: Kristian
authors: K
authors: Ufer
authors: Direccion de Investigación y Posgrado, Instituto Mexicano del Petróleo, México.
authors: Eduardo
authors: E
authors: Palacios
authors: Direccion de Investigación y Posgrado, Instituto Mexicano del Petróleo, México.
authors: Ascención
authors: A
authors: Montoya
mesh_terms: D000538:Aluminum Silicates; D001118:Argentina; D001546:Bentonite / Q000737:chemistry*; D048708:Cell Growth Processes; D045744:Cell Line, Tumor; D000077215:Clay; D006801:Humans; D007194:India; D007214:Indonesia; D013499:Surface Properties
chemical_list: D000538:Aluminum Silicates; D001546:Bentonite; D000077215:Clay
keywords: Cell proliferation response; Swelling