title: Perfusion Parameters in Dynamic Contrast-enhanced MRI and Apparent Diffusion Coefficient Value in Diffusion-weighted MRI:: Association with Prognostic Factors in Breast Cancer.
abstract: OBJECTIVE
  To evaluate the association of prognostic factors and subtypes of breast cancer with perfusion parameters in dynamic contrast-enhanced magnetic resonance imaging and apparent diffusion coefficient (ADC) values in diffusion-weighted magnetic resonance imaging.
  
  
  METHODS
  Quantitative perfusion parameters (constant of transfer from plasma to interstitium, constant of transfer from the interstitium to the plasma, extravascular/extracellular volume per unit of volume of tissue [ve], and initial area under the concentration curve [iAUC]) and ADC values in the entire tumor volume of 52 invasive ductal carcinomas were obtained using histogram analysis. Four measures (25th percentile, mean, median, 75th percentile) were calculated for each parameter and the ADC value. Associations of perfusion parameters and ADC values with prognostic factors and tumor subtypes were analyzed.
  
  
  RESULTS
  Among perfusion parameters, iAUCmean and iAUCmedian were greater in tumors larger than 2 cm (8.23 ± 2.33, 8.64 ± 2.67 × 10(4)) than in those smaller than 2 cm (6.99 ± 1.92, 7.04 ± 2.15 × 10(4); P = 0.046, 0.023). Ve median was higher in tumors with progesterone receptor (PR) positivity (0.54 ± 0.18) than in those with PR negativity (0.44 ± 0.1, P = 0.041). There were higher ADCmean and ADCmedian in tumors with human epidermal growth factor receptor 2 (HER2) positivity (1.306 and 1.278 × 10(-3)mm(2)/s) than in those with HER2 negativity (1.078 and 1.053 × 10(-3)mm(2)/s; P = 0.012 and 0.020). Higher ADCmean and ADCmedian were observed in HER2-enriched type (1.404 and 1.378 × 10(-3)mm(2)/s) than in luminal type (1.096 and 1.073 × 10(-3)mm(2)/s; P = 0.030 and 0.045).
  
  
  CONCLUSIONS
  Among perfusion parameters, iAUC was associated with tumor size and ve median was associated with PR positivity. Mean and median ADC values showed positive correlation with HER2-positive and HER2-enriched tumors.
authors: Department of Radiology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Banpo-daero 222, Seocho-gu, Seoul 137-701, Republic of Korea.
authors: Hyun Sil
authors: HS
authors: Lee
authors: Department of Radiology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Banpo-daero 222, Seocho-gu, Seoul 137-701, Republic of Korea. Electronic address: rad-ksh@catholic.ac.kr.
authors: Sung Hun
authors: SH
authors: Kim
authors: Department of Radiology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Banpo-daero 222, Seocho-gu, Seoul 137-701, Republic of Korea.
authors: Bong Joo
authors: BJ
authors: Kang
authors: Department of Radiology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Banpo-daero 222, Seocho-gu, Seoul 137-701, Republic of Korea.
authors: Ji Eun
authors: JE
authors: Baek
authors: Department of General Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors: Byung Joo
authors: BJ
authors: Song
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results; D047368:Tumor Burden
chemical_list: D003287:Contrast Media
keywords: ADC value; Breast cancer; magnetic resonance imaging; perfusion; prognostic factor