title: Intensity-modulated radiotherapy or volumetric-modulated arc therapy in patients with head and neck cancer: Focus on salivary glands dosimetry.
abstract: Despite radiotherapy (RT) technical improvements, high salivary dysfunction rates are still reported in patients with head and neck squamous cell carcinoma (HNSCC). The purpose of the present study was to report salivary glands dosimetry with volumetric-modulated arc therapy (VMAT) and intensity-modulated RT (IMRT).
  
  
  
  Dosimetry of consecutive patients receiving IMRT or VMAT for proven HNSCC between 2007 and 2013 were retrospectively reviewed.
  
  
  
  Data of 609 patients were studied. Mean dose, mean maximum dose, and mean percentage of salivary gland volume receiving at least 26 Gy (V26) of the contralateral parotid were 24.50 Gy (range, 0-70.4 Gy), 39.08 Gy (range, 0.38-76.45 Gy), and 40.92% (range, 0% to 100%), respectively. Mean and maximum dose on contralateral submandibular gland were 48.18 Gy (range, 0.19-70.73 Gy), and 61.25 Gy (range, 0-75.8 Gy), respectively.
  
  
  
  Target volume coverage still has to be prioritized over organs at risk (OAR) sparing with new RT techniques. Submandibular glands are not sufficiently taken into account in guidelines. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1028-1034, 2016.
authors: Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Alexis
authors: A
authors: Vallard
authors: Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Jean-Baptiste
authors: JB
authors: Guy
authors: Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Sylvie
authors: S
authors: Mengue Ndong
authors: Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Nicolas
authors: N
authors: Vial
authors: Department of Medical Oncology, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Romain
authors: R
authors: Rivoirard
authors: Department of Radiotherapy, Claude Bernard Clinic, Albi, France.
authors: Pierre
authors: P
authors: Auberdiac
authors: Department of Medical Oncology, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Benoîte
authors: B
authors: Méry
authors: Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Julien
authors: J
authors: Langrand-Escure
authors: Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Sophie
authors: S
authors: Espenel
authors: Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Coralie
authors: C
authors: Moncharmont
authors: Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Majed
authors: M
authors: Ben Mrad
authors: Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Peng
authors: P
authors: Diao
authors: Department of Medical Physics, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Dominique
authors: D
authors: Goyet
authors: Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France.
authors: Nicolas
authors: N
authors: Magné
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D015331:Cohort Studies; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D058958:Organs at Risk / Q000528:radiation effects*; D011379:Prognosis; D011832:Radiation Injuries / Q000517:prevention & control; D011874:Radiometry; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012189:Retrospective Studies; D012469:Salivary Glands / Q000528:radiation effects*; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis; D016896:Treatment Outcome; D014987:Xerostomia / Q000517:prevention & control*
keywords: dosimetry; intensity-modulated radiotherapy; parotid gland; submandibular gland; volumetric-modulated arc therapies