title: Apparent diffusion coefficient value in invasive ductal carcinoma at 3.0 Tesla: is it correlated with prognostic factors?
abstract: OBJECTIVE
  To investigate the correlation between apparent diffusion coefficient (ADC) values and prognostic factors in patients with invasive ductal carcinoma (IDC).
  
  
  METHODS
  48 lesions belonging to 47 patients with histopathologically proven IDC were examined using conventional MR and diffusion-weighted imaging at a 3.0-T system. All of the patients had modified radical mastectomies or breast-sparing surgery plus axillary lymph node dissection. The ADC values acquired from the ADC maps consisted of six different b-values (0, 50, 100, 500, 1000 and 1500 s mm(-2)) and were compared with the patients' ages, tumour size, histological grade of the lesions, tumour localization, lesions' distance to skin surface and nipples, the existence of axillary lymph node involvement, the number of involved axillary lymph nodes, oestrogen/progesterone receptor status, peritumoral lymphovascular invasion status and the existence of human epidermal growth factor 2 (c-erbB-2) overexpression.
  
  
  RESULTS
  A statistically significant relationship was found regarding axillary lymph node involvement (p = 0.027), and oestrogen/progesterone receptor status (p = 0.013). No significant relationship was detected regarding other prognostic factors (p > 0.05).
  
  
  CONCLUSIONS
  Among various prognostic factors, ADC values were significantly correlated with only axillary lymph node positivity and oestrogen/progesterone receptor status.
  
  
  CONCLUSIONS
  In the present study, the relationship between ADC values of IDC lesions that are acquired at a high magnetic field (3.0 T) system by using multiple b-values and some specific prognostic factors that were not evaluated before in the medical literature was investigated.
authors: 1 Department of Radiology, Gulhane Military Medical School, Ankara, Turkey.
authors: Inanc
authors: I
authors: Guvenc
authors: 2 Department of Radiology, Sirnak Military Hospital, Sirnak, Turkey.
authors: Sinan
authors: S
authors: Akay
authors: 1 Department of Radiology, Gulhane Military Medical School, Ankara, Turkey.
authors: Selami
authors: S
authors: Ince
authors: 3 Department of General Surgery, Gulhane Military Medical School, Ankara, Turkey.
authors: Ramazan
authors: R
authors: Yildiz
authors: 3 Department of General Surgery, Gulhane Military Medical School, Ankara, Turkey.
authors: Zafer
authors: Z
authors: Kilbas
authors: 4 Department of Public Health, Gulhane Military Medical School, Ankara, Turkey.
authors: Fahrettin G
authors: FG
authors: Oysul
authors: 1 Department of Radiology, Gulhane Military Medical School, Ankara, Turkey.
authors: Mustafa
authors: M
authors: Tasar
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human