title: [Clinical observation of a new anti-VEGF drugs conbercept for wet age-related macular degeneration].
abstract: OBJECTIVE
  To observe the efficacy and safety of intravitreal injection of conbercept, a new drugs of VEGFR fusion proteins, on wet age-related macular degeneration (wAMD).
  
  
  METHODS
  To analyze retrospectively the clinical data of 58 patients with wet wAMD, which was diagnosed by examination of ETDRS charts, color fundus photograph, fluorescein angiography (FFA) and optical coherence tomography (OCT), were underwent intravitreal injection conbercept 0.5 mg (0.05 ml of 10 g/L). Follow-up time was 6 to 12 months.Visual acuity (ETDRS charts letter), retinal thickness, leakage of CNV and operative complications before and after the treatment were analyzed.
  
  
  RESULTS
  Conbercept injection therapeutic times were 3-5, the average therapeutic times were 3.05. At the end of the follow-up period, the mean letter of ETDRS charts was 50.20±12.87, increased 26.20 letters (t=2.936, P<0.01). the ETDRS charts improved 15 or more letters in 33 eyes (53.23%), decreased more than 15 letters in 2 eyes (3.23%); the average foveal thickness on OCT images were (223±74) µm after treatment, decreased significantly (t=3.669, P<0.01) ; FFA showed CNV complete closure in 34 eyes (54.84%), partial closure in 23 eyes (37.10%), no change in 5 eyes (8.06%). IOP increased in 2 eyes after treatment and recovered within one week.
  
  
  CONCLUSIONS
  Intravitreal injection of conbercept for wAMD was well tolerated, with an improvement in BCVA, macular edema and leakage of CNV, reduce the risk of rehaemorrhagia.
authors: Department of Ophthalmology, the First Hospital of Qiqihar, Qiqihar 161000, Heilongjiang Province, China.
authors: Hang
authors: H
authors: Lu
authors: Department of Ophthalmology, the First Hospital of Qiqihar, Qiqihar 161000, Heilongjiang Province, China; Email: cjl35jjcc@126.com.
authors: Jinglin
authors: J
authors: Cui
authors: Department of Ophthalmology, the First Hospital of Qiqihar, Qiqihar 161000, Heilongjiang Province, China.
authors: Hui
authors: H
authors: Dong
authors: Department of Ophthalmology, the First Hospital of Qiqihar, Qiqihar 161000, Heilongjiang Province, China.
authors: Binjiang
authors: B
authors: Luo
authors: Department of Ophthalmology, the First Hospital of Qiqihar, Qiqihar 161000, Heilongjiang Province, China.
authors: Weiwei
authors: W
authors: Xiu
authors: Department of Ophthalmology, the First Hospital of Qiqihar, Qiqihar 161000, Heilongjiang Province, China.
authors: Huimei
authors: H
authors: Li
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D005451:Fluorescein Angiography; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use*; D012160:Retina; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*; D014792:Visual Acuity; D057135:Wet Macular Degeneration / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D020533:Angiogenesis Inhibitors; D011993:Recombinant Fusion Proteins; D042461:Vascular Endothelial Growth Factor A; C527363:KH902 fusion protein