title: The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology.
abstract: Cdkn1A-interacting zinc finger protein 1 (CIZ1) was first identified in a yeast-2-hybrid system searching for interacting proteins of CDK2 inhibitor p21(Cip1/Waf1). Ciz1 also binds to CDK2, cyclin A, cyclin E, CDC6, PCNA, TCF4 and estrogen receptor-α. Recent studies reveal numerous biological functions of CIZ1 in DNA replication, cell proliferation, and differentiation. In addition, splicing variants of CIZ1 mRNA is associated with a variety of cancers and Alzheimer's disease, and mutations of the CIZ1 gene lead to cervical dystonia. CIZ1 expression is increased in cancers and rheumatoid arthritis. In this review, we will summarize the biological functions and molecular mechanisms of CIZ1 in these physiological and pathological processes.
authors: Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, China. qiangliu.sdu@gmail.com.
authors: Qiang
authors: Q
authors: Liu
authors: Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021, China. judyniuna@163.com.
authors: Na
authors: N
authors: Niu
authors: The Research Center for Advanced Science and Technology, and Isotope Science Center, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. wada-y@lsbm.org.
authors: Youichiro
authors: Y
authors: Wada
authors: Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, China. ju.liu@sdu.edu.cn.
authors: Ju
authors: J
authors: Liu
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D002454:Cell Differentiation; D049109:Cell Proliferation; D004261:DNA Replication; D004198:Disease Susceptibility; D005786:Gene Expression Regulation; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: C400423:Ciz1 protein, human; D009687:Nuclear Proteins
keywords: CIZ1; DNA replication; alternative splicing; cell cycle