title: Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids.
abstract: By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2-21 were synthesized using a simple and convenient method. Evaluation of these compounds against different cell lines identified compounds 7 and 17 as most active anticancer agents as they showed effectiveness on the four tested cell lines. The anticancer screening results of the tested compounds provides an encouraging framework that could lead to the development of potent new anticancer agents.
authors: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. mmsghorab@yahoo.com.|Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo 11371, Egypt. mmsghorab@yahoo.com.
authors: Mostafa M
authors: MM
authors: Ghorab
authors: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. msalsaid@ksu.edu.sa.
authors: Mansour S
authors: MS
authors: Alsaid
authors: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. msdosari@yahoo.com.
authors: Mohammed S
authors: MS
authors: Al-Dosari
authors: Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo 11371, Egypt. marwagalalgazzar@yahoo.com.
authors: Marwa G
authors: MG
authors: El-Gazzar
authors: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. khalid_parvez@yahoo.com.
authors: Mohammad K
authors: MK
authors: Parvez
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines
keywords: anticancer activity; quinazoline; sulfonamides; synthesis