title: What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?
abstract: Couples of whom the woman has had a miscarriage have two major concerns: the cause and possible risk of recurrence. Unfortunately, a significant proportion of cases of recurrent miscarriage (RM) remain unexplained despite detailed investigation. Because data suggest that regulatory T cells (Treg) are involved in the maternal acceptance of the allogeneic foetus, RM could possibly be explained by a disturbance of the Treg network. The possible role of Tregs in RM is described in this review, as well as their potential application in diagnostics and therapeutic intervention trials.
authors: Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
authors: M H C
authors: MH
authors: Craenmehr
authors: Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
authors: S
authors: S
authors: Heidt
authors: Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
authors: M
authors: M
authors: Eikmans
authors: Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
authors: F H J
authors: FH
authors: Claas
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology*; D005260:Female; D005333:Fetus / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D011247:Pregnancy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
keywords: immune system; pregnancy; recurrent miscarriage; regulatory T cell; tolerance