title: Progress in treatments for colorectal cancer peritoneal metastases during the years 2010-2015. A systematic review.
abstract: Peritoneal metastases (PM) from colorectal cancer (CRC) were traditionally associated with bad prognosis. Only recently, cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has resulted in survival improvements. A systematic literature search between January 2010 and June 2015 was performed. Studies were selected and appraised according to predetermined criteria. Nineteen cohort studies, and thirteen comparative studies of CRS/HIPEC were included. The weighted median overall survival was 31.6 months (range 16-51). Major morbidity was 17.6-52.4% (weighted average 32.6%). Mortality was 0-8.1% (weighted average 2.9%). Additional relevant topics, such as CRC-PM prevalence, results by systemic therapies, preoperative work-up, and technical aspects were summarized through a narrative review. The recent literature suggests that CRS/HIPEC is gaining acceptance as standard of care for selected CRC-PM patients. Refinement of selection criteria, and rationalization of comprehensive systemic and local-regional management is ongoing. Prevention and early treatment of PM are new and promising options.
authors: Peritoneal Malignancy Program, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian, 1 20133 Milano, Italy.
authors: Dario
authors: D
authors: Baratti
authors: Peritoneal Malignancy Program, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian, 1 20133 Milano, Italy.
authors: Shigeki
authors: S
authors: Kusamura
authors: Medical Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian, 1 20133 Milano, Italy.
authors: Filippo
authors: F
authors: Pietrantonio
authors: Peritoneal Malignancy Program, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian, 1 20133 Milano, Italy.
authors: Marcello
authors: M
authors: Guaglio
authors: Medical Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian, 1 20133 Milano, Italy.
authors: Monica
authors: M
authors: Niger
authors: Peritoneal Malignancy Program, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian, 1 20133 Milano, Italy. Electronic address: marcello.deraco@istitutotumori.mi.it.
authors: Marcello
authors: M
authors: Deraco
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D065426:Cytoreduction Surgical Procedures / Q000379:methods; D006801:Humans; D006979:Hyperthermia, Induced; D036502:Infusions, Intralesional; D019990:Perioperative Care / Q000379:methods; D010534:Peritoneal Neoplasms / Q000453:epidemiology / Q000556:secondary* / Q000628:therapy*
keywords: Colorectal cancer; Cytoreductive surgery; HIPEC; Hyperthermic intraperitoneal chemotherapy; Liver metastasis; Peritoneal metastasis