title: Spontaneous regression and complete disappearance of the vein of Galen aneurysmal malformation.
abstract: BACKGROUND
  Thrombosis is frequently observed in Galen malformation, but propagation of thrombosis resulting in the disappearance of the aneurysmal malformation is a very rare clinical condition.
  
  
  METHODS
  A rare case of spontaneous regression and disappearance of the vein of Galen aneurysmal malformation (VoGAM) in a pediatric patient with repeated generalized seizure, increased head circumference, and congestive heart failure is recorded. The course of regression from infancy to 8 years of age has been depicted. Radiological studies initially demonstrated VoGAM complicated by an intra-cerebral hemorrhage and hydrocephalus, which later underwent spontaneous regression. Long-term clinical and radiological follow-up is presented.
  
  
  CONCLUSIONS
  Different conditions including hemodynamic alteration, compression of adjacent hematoma, and narrowing of related vascular structures have been described to cause thrombosis of VoGAM. The relevant literature to address possible mechanism is reviewed.
authors: Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran.
authors: Ramin
authors: R
authors: Mahmoodi
authors: Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Science, Tehran, Iran.
authors: Zohreh
authors: Z
authors: Habibi
authors: Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Science, Tehran, Iran.
authors: Vahid
authors: V
authors: Heidari
authors: Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Science, Tehran, Iran. nejat@sina.tums.ac.ir.
authors: Farideh
authors: F
authors: Nejat
mesh_terms: D002543:Cerebral Hemorrhage / Q000150:complications; D002648:Child; D006333:Heart Failure / Q000150:complications; D006801:Humans; D006849:Hydrocephalus / Q000150:complications; D008137:Longitudinal Studies; D008297:Male; D059906:Neuroimaging; D020127:Recovery of Function / Q000502:physiology*; D012640:Seizures / Q000150:complications / Q000000981:diagnostic imaging; D054080:Vein of Galen Malformations / Q000150:complications / Q000000981:diagnostic imaging / Q000209:etiology*
keywords: Aneurysm; Galen; Regression