title: Efficient one-pot synthesis of 1-arylcycloprop-2-ene-1-carboxamides.
abstract: An expeditious and cost-efficient method for synthesis of 1-arylcycloprop-2-ene-1-carboxamides was developed. This one-pot protocol involving coupling of amines with acyl chlorides, generated upon treatment of cyclopenylcarboxylic acids with oxalyl chloride, is applicable for the preparation of sensitive products with a reactive, unsubstituted strained double bond.
authors: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS 66045-7582, USA. mrubin@ku.edu.
authors: Andrew
authors: A
authors: Edwards
authors: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS 66045-7582, USA. mrubin@ku.edu and Department of Chemistry, North Caucasus State University, 1a Pushkin St., Stavropol 355009, Russian Federation.
authors: Michael
authors: M
authors: Rubin
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000577:Amides; D002264:Carboxylic Acids