title: Association Study of 60 Candidate Genes with Antipsychotic-induced Weight Gain in Schizophrenia Patients.
abstract: BACKGROUND
  This study aimed to investigate the association of multiple candidate genes with weight gain and appetite change during antipsychotic treatment.
  
  
  METHODS
  A total of 233 single nucleotide polymorphisms (SNPs) within 60 candidate genes were genotyped. BMI changes for up to 8 weeks in 84 schizophrenia patients receiving antipsychotic medication were analyzed using a linear mixed model. In addition, we assessed appetite change during antipsychotic treatment in a different group of 46 schizophrenia patients using the Drug-Related Eating Behavior Questionnaire.
  
  
  RESULTS
  No SNP showed a statistically significant association with BMI or appetite change after correction for multiple testing. We observed trends of association (P<0.05) between 19 SNPs of 11 genes and weight gain, and between 7 SNPs of 5 genes and appetite change. In particular, rs696217 in GHRL showed suggestive evidence of association with not only weight gain (P=0.001) but also appetite change (P=0.042). Patients carrying the GG genotype of rs696217 exhibited higher increase in both BMI and appetite compared to patients carrying the GT/TT genotype.
  
  
  CONCLUSIONS
  Our findings suggested the involvement of a GHRL polymorphism in weight gain, which was specifically mediated by appetite change, during antipsychotic treatment in schizophrenia patients.
authors: Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
authors: S
authors: S
authors: Ryu
authors: Department of Statistics, Seoul National University, Seoul, Korea.
authors: I-S
authors: IS
authors: Huh
authors: Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Korea.
authors: E-Y
authors: EY
authors: Cho
authors: Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
authors: Y
authors: Y
authors: Cho
authors: Department of Statistics, Seoul National University, Seoul, Korea.
authors: T
authors: T
authors: Park
authors: Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
authors: S C
authors: SC
authors: Yoon
authors: Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors: Y H
authors: YH
authors: Joo
authors: Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
authors: K S
authors: KS
authors: Hong
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001066:Appetite / Q000187:drug effects / Q000235:genetics; D015992:Body Mass Index; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D054439:Ghrelin / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D054439:Ghrelin