title: Simultaneous Rapid Determination of the Solubility and Diffusion Coefficients of a Poorly Water-Soluble Drug Based on a Novel UV Imaging System.
abstract: The solubility and diffusion coefficient are two of the most important physicochemical properties of a drug compound. In practice, both have been measured separately, which is time consuming. This work utilizes a novel technique of UV imaging to determine the solubility and diffusion coefficients of poorly water-soluble drugs simultaneously. A 2-step optimal method is proposed to determine the solubility and diffusion coefficients of a poorly water-soluble pharmaceutical substance based on the Fick's second law of diffusion and UV imaging measurements. Experimental results demonstrate that the proposed method can be used to determine the solubility and diffusion coefficients of a drug with reasonable accuracy, indicating that UV imaging may provide a new opportunity to accurately measure the solubility and diffusion coefficients of a poorly water-soluble drug simultaneously and rapidly.
authors: School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.
authors: Yan
authors: Y
authors: Lu
authors: School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK. Electronic address: mli@dmu.ac.uk.
authors: Mingzhong
authors: M
authors: Li
mesh_terms: D002220:Carbamazepine / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D004867:Equipment Design; D007052:Ibuprofen / Q000737:chemistry*; D021621:Imaging, Three-Dimensional / Q000295:instrumentation / Q000379:methods*; D008956:Models, Chemical; D012995:Solubility; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D002220:Carbamazepine; D007052:Ibuprofen
keywords: Fick's second law of diffusion; UV imaging; diffusion coefficient; solubility