title: Bladder Cancer is Associated with Low Plasma 25-hydroxyvitamin D Concentrations in Tunisian Population.
abstract: Little evidence suggests an impact of vitamin D on bladder cancer risk in Caucasians. This study aimed to investigate association of plasma 25-hydroxyvitamin D (25-OHD) with urothelial bladder cancer (UBC) risk in Tunisians. A case-control study included 250 patients with UBC and 250 healthy controls. Plasma 25-OHD was assessed by a competitive chemiluminescence immunoassay. Vitamin D deficiency and insufficiency were defined as 25-OHD <30 nmol/L and 30 to 49.99 nmol/L, respectively. Logistic regression models adjusting for gender, age, smoking status, duration of smoking, occupational exposure, and season were applied. Vitamin D deficiency (50.4% vs. 34.8%; P < 0.001) and insufficiency (40.4% vs. 26.8%; P < 0.001) were more frequent in patients than controls. Multivariate analysis showed that UBC is associated with vitamin D deficiency [odd-ratio (95% confidence interval), 3.71 (1.76-7.80); P = 0.001] and vitamin D insufficiency [2.65 (1.40-5.01); P = 0.003]. Other predictors of UBC were female gender, tobacco use, smoking duration, and occupational exposure. Plasma 25-OHD concentrations are low in Tunisian patients with UBC. These findings support experimental and epidemiological evidence of protective role of vitamin D against UBC but could not ascertain causal relationship. Further prospective studies and clinical trials are warranted to check causality.
authors: a UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, Faculty of Sciences of Tunis, University of Tunis El Manar , Tunis , Tunisia.
authors: Mohamed Kacem
authors: MK
authors: Ben Fradj
authors: b Department of Urology , Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.
authors: Mohamed Mourad
authors: MM
authors: Gargouri
authors: c UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.
authors: Mohamed Bassem
authors: MB
authors: Hammami
authors: b Department of Urology , Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.
authors: Sami
authors: S
authors: Ben Rhouma
authors: c UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.
authors: Amani
authors: A
authors: Kallel
authors: c UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.
authors: Riadh
authors: R
authors: Jemaa
authors: c UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.
authors: Moncef
authors: M
authors: Feki
authors: b Department of Urology , Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.
authors: Yassine
authors: Y
authors: Nouira
authors: c UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.
authors: Naziha
authors: N
authors: Kaabachi
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014416:Tunisia; D001749:Urinary Bladder Neoplasms / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D