title: Comparative pharmacokinetics of a proliposome formulation of Ginkgo biloba extract and Ginaton in rats by a sensitive ultra performance liquid chromatography-tandem mass spectrometry method.
abstract: As a novel oral drug delivery system, proliposome was applied to improve the solubility of active components of Ginkgo biloba extract (GbE). There are currently few reports focusing on the pharmacokinetic characteristics of proliposome of GbE (GbP). A rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous quantification of active components of GbP and a commercial tablet product (Ginaton) in rat plasma was developed and successfully validated. The method was applied to the comparative pharmacokinetic evaluation of GbP and Ginaton in rat plasma. The results indicated that GbP has a significant effect on absorption, elimination and bioavailability of flavonoids and terpenoid lactones in comparison with Ginaton. The obtained results would be helpful for evaluating the absorption mechanism in the gastrointestinal tract in pharmacokinetic level and guiding the development of the novel oral drug delivery system.
authors: College of Life Sciences, Jinlin University, Changchun 130012, China.
authors: Bin
authors: B
authors: Zheng
authors: College of Life Sciences, Jinlin University, Changchun 130012, China.
authors: Gaoyang
authors: G
authors: Xing
authors: College of Life Sciences, Jinlin University, Changchun 130012, China.
authors: Ye
authors: Y
authors: Bi
authors: College of Life Sciences, Jinlin University, Changchun 130012, China.
authors: Guodong
authors: G
authors: Yan
authors: College of Life Sciences, Jinlin University, Changchun 130012, China.
authors: Jing
authors: J
authors: Wang
authors: College of Life Sciences, Jinlin University, Changchun 130012, China.
authors: Yingkun
authors: Y
authors: Cheng
authors: College of Life Sciences, Jinlin University, Changchun 130012, China.
authors: Yan
authors: Y
authors: Liu
authors: Department of Geology, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; Faculty of Science & Natural Resources, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia.
authors: Muhammad Aqeel
authors: MA
authors: Ashraf
authors: College of Life Sciences, Jinlin University, Changchun 130012, China.
authors: Jing
authors: J
authors: Xie
keywords: Ginkgo biloba extract; Pharmacokinetics; Proliposome; Ultra performance liquid chromatography–tandem mass spectrometry