title: Is the effect of topical intranasal steroids on obstructive adenoids transient or long-lasting? Case series and systematic review of literature.
abstract: OBJECTIVE
  To study and review the short- and long-term effects of intranasal steroids on obstructive adenoids.
  
  
  METHODS
  In this prospective cohort study, 19 children previously treated with mometasone furoate for 3 months were contacted at 3, 6 and 12 months after cessation of treatment. Main outcome measures included: change in severity of nasal obstruction, allergic rhinitis and obstructive symptoms. A systematic review of literature was also performed.
  
  
  RESULTS
  By one year, 25 per cent of patients required adenoidectomy; the remaining children had no significant change in clinical score (p = 0.464), obstruction severity (p = 0.191) or allergic symptoms (p = 0.284). Fourteen pertinent studies were identified; all but one study showed improvement in the patients' symptoms and/or degree of obstruction. Two studies with follow up reaching 25 months showed positive effects.
  
  
  CONCLUSIONS
  The short-term positive effect of some intranasal steroids on obstructive adenoids seems to persist in a significant number of patients after the cessation of treatment.
authors: Department of Otolaryngology Head and Neck Surgery,Faculty of Medicine and Medical Center,American University of Beirut,Lebanon.
authors: M A
authors: MA
authors: Bitar
authors: Department of Otolaryngology Head and Neck Surgery,Faculty of Medicine and Medical Center,American University of Beirut,Lebanon.
authors: J
authors: J
authors: Nassar
authors: private clinic (paediatrics),Beirut,Lebanon.
authors: R
authors: R
authors: Dana
mesh_terms: D000233:Adenoidectomy; D000234:Adenoids / Q000187:drug effects* / Q000601:surgery; D000281:Administration, Intranasal; D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D000068656:Mometasone Furoate / Q000008:administration & dosage* / Q000494:pharmacology; D015508:Nasal Obstruction / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D011446:Prospective Studies; D065631:Rhinitis, Allergic / Q000188:drug therapy / Q000209:etiology; D012720:Severity of Illness Index; D013995:Time
chemical_list: D000893:Anti-Inflammatory Agents; D000068656:Mometasone Furoate
keywords: Adenoid; Follow-Up Studies; Intranasal Drug Administration; Mometasone Furoate; Nasal Obstruction; Steroids