title: Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer.
abstract: The challenge in photothermal therapy (PTT) is to develop biocompatible photothermal transducers that can absorb and convert near-infrared (NIR) light into heat with high efficiency. Herein, we report salt-induced aggregation of gold nanoparticles (GNPs) in biological media to form highly efficient and biocompatible NIR photothermal transducers for PTT and photothermal/photoacoustic (PT/PA) imaging of cancer. The GNP depots in situ formed by salt-induced aggregation of GNPs show strong NIR absorption induced by plasmonic coupling between adjacent GNPs and very high photothermal conversion efficiency (52%), enabling photothermal destruction of tumor cells. More interestingly, GNPs in situ aggregate in tumors to form GNP depots, enabling simultaneous PT/PA imaging and PTT of the tumors. These findings may provide a simple and effective way to develop a new class of intelligent and biocompatible NIR photothermal transducers with high efficiency for PT/PA imaging and PTT.
authors: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. gaoweiping@tsinghua.edu.cn.
authors: Mengmeng
authors: M
authors: Sun
authors: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. gaoweiping@tsinghua.edu.cn.
authors: Fei
authors: F
authors: Liu
authors: Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
authors: Yukun
authors: Y
authors: Zhu
authors: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. gaoweiping@tsinghua.edu.cn.
authors: Wansheng
authors: W
authors: Wang
authors: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. gaoweiping@tsinghua.edu.cn.
authors: Jin
authors: J
authors: Hu
authors: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. gaoweiping@tsinghua.edu.cn.
authors: Jing
authors: J
authors: Liu
authors: College of Engineering and Peking University Third Hospital, Peking University, Beijing 100871, China.
authors: Zhifei
authors: Z
authors: Dai
authors: Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
authors: Kun
authors: K
authors: Wang
authors: Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors: Yen
authors: Y
authors: Wei
authors: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. gaoweiping@tsinghua.edu.cn.
authors: Jing
authors: J
authors: Bai
authors: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. gaoweiping@tsinghua.edu.cn.
authors: Weiping
authors: W
authors: Gao
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D000067493:Dynamic Light Scattering; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy; D061088:Photoacoustic Techniques; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry*; D015996:Survival Rate; D014183:Transplantation, Heterologous
chemical_list: D011092:Polyethylene Glycols; D012965:Sodium Chloride; D006046:Gold