title: Impaired learning and memory in CD38 null mutant mice.
abstract: CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca(2+) from intracellular stores. Recently, CD38 has been shown to regulate oxytocin release from hypothalamic neurons. Importantly, CD38 mutations are associated with autism spectrum disorders (ASD) and CD38 knockout (CD38(-/-)) mice display ASD-like behavioral phenotypes including deficient parental behavior and poor social recognition memory. Although ASD and learning deficits commonly co-occur, the role of CD38 in learning and memory has not been investigated. We report that CD38(-/-) mice show deficits in various learning and memory tasks such as the Morris water maze, contextual fear conditioning, and the object recognition test. However, either long-term potentiation or long-term depression is not impaired in the hippocampus of CD38(-/-) mice. Our results provide convincing evidence that CD38(-/-) mice show deficits in various learning and memory tasks including spatial and non-spatial memory tasks. Our data demonstrate that CD38 is critical for regulating hippocampus-dependent learning and memory without modulating synaptic plasticity.
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea. somikim0223@snu.ac.kr.
authors: Somi
authors: S
authors: Kim
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea. thkim3@snu.ac.kr.
authors: TaeHyun
authors: T
authors: Kim
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea. hrlee15@gmail.com.
authors: Hye-Ryeon
authors: HR
authors: Lee
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea. grace0610@hanmail.net.
authors: Eun-Hye
authors: EH
authors: Jang
authors: Department of Life Science, Chung-Ang University, Seoul, 156-756, South Korea. 89heestory@gmail.com.
authors: Hyun-Hee
authors: HH
authors: Ryu
authors: Department of Life Science, Chung-Ang University, Seoul, 156-756, South Korea. 910kang@gmail.com.
authors: Minkyung
authors: M
authors: Kang
authors: Departments of Biochemistry, Institute of Cardiovascular Research, Chonbuk National University Medical School, Jeonju, 561-182, South Korea. syrah1004@hanmail.net.
authors: So-Young
authors: SY
authors: Rah
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea. juyoun714@gmail.com.
authors: Juyoun
authors: J
authors: Yoo
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea. cbbl@snu.ac.kr.
authors: Bolam
authors: B
authors: Lee
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea. acmlaj3@snu.ac.kr.
authors: Jae-Ick
authors: JI
authors: Kim
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea. cslim@snu.ac.kr.
authors: Chae Seok
authors: CS
authors: Lim
authors: Department of Physiology, Seoul National University College of Medicine, Seoul, 110-799, South Korea. sangjkim@snu.ac.kr.
authors: Sang Jeong
authors: SJ
authors: Kim
authors: Departments of Biochemistry, Institute of Cardiovascular Research, Chonbuk National University Medical School, Jeonju, 561-182, South Korea. uhkim@chonbuk.ac.kr.
authors: Uh-Hyun
authors: UH
authors: Kim
authors: Department of Life Science, Chung-Ang University, Seoul, 156-756, South Korea. yongseok@cau.ac.kr.
authors: Yong-Seok
authors: YS
authors: Lee
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea. kaang@snu.ac.kr.
authors: Bong-Kiun
authors: BK
authors: Kaang
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000172:deficiency* / Q000378:metabolism; D000818:Animals; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D008568:Memory; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009473:Neuronal Plasticity; D012919:Social Behavior; D009435:Synaptic Transmission
chemical_list: D051997:ADP-ribosyl Cyclase 1