title: Synthesis of ZnO nanowire arrays/3D graphene foam and application for determination of levodopa in the presence of uric acid.
abstract: Three-dimensional (3D) graphene foam (GF) was prepared by chemical vapor deposition (CVD) using nickel foam as the template. ZnO nanowire arrays (ZnO NWAs) were vertically grown on the 3D GF by hydrothermal synthesis to prepare ZnO NWAs/GF. This hybrid combines the properties of ZnO NWAs and 3D GF, which has favorable electrocatalysis and outstanding electrical conductivity. The vertically aligned ZnO NWAs grown on the GF enlarged the electroactive surface area, which was investigated from the Fe(CN)63-4+redox kinetic study. The ZnO NWAs/GF was used as an electrochemical electrode for the determination of Levodopa (LD) in the presence of uric acid (UA). The electrochemical responses of the ZnO NWAs/GF electrode were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results show that the sensitivity of the electrode for LD is 3.15μAμM-1in the concentration range of 0.05-20μM and the measured detection limit of the electrode for LD is 50nM. The electrode also shows good selectivity, reproducibility and stability. The proposed electrode is succsefully used to determine LD in human plasma samples and it is potential for use in clinical research.
authors: School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin 150040, People's Republic of China. Electronic address: hyyue@hrbust.edu.cn.
authors: Hong Yan
authors: HY
authors: Yue
authors: School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin 150040, People's Republic of China.
authors: Hong
authors: H
authors: Zhang
authors: Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China.
authors: Shuo
authors: S
authors: Huang
authors: School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin 150040, People's Republic of China.
authors: Xuan Yu
authors: XY
authors: Lin
authors: School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin 150040, People's Republic of China.
authors: Xin
authors: X
authors: Gao
authors: School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin 150040, People's Republic of China.
authors: Jing
authors: J
authors: Chang
authors: School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin 150040, People's Republic of China.
authors: Long Hui
authors: LH
authors: Yao
authors: School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin 150040, People's Republic of China.
authors: Er Jun
authors: EJ
authors: Guo
mesh_terms: D015374:Biosensing Techniques / Q000379:methods; D015259:Dopamine Agents / Q000097:blood*; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D007980:Levodopa / Q000097:blood*; D057230:Limit of Detection; D008958:Models, Molecular; D053770:Nanowires / Q000737:chemistry* / Q000648:ultrastructure; D014527:Uric Acid / Q000097:blood; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D015259:Dopamine Agents; D014527:Uric Acid; D007980:Levodopa; D006108:Graphite; D015034:Zinc Oxide
keywords: Electrochemical biosensors; Graphene foam; Levodopa; Uric acid; ZnO nanowire arrays