title: Viral metagenomics: are we missing the giants?
abstract: Amoeba-infecting giant viruses are recently discovered viruses that have been isolated from diverse environments all around the world. In parallel to isolation efforts, metagenomics confirmed their worldwide distribution from a broad range of environmental and host-associated samples, including humans, depicting them as a major component of eukaryotic viruses in nature and a possible resident of the human/animal virome whose role is still unclear. Nevertheless, metagenomics data about amoeba-infecting giant viruses still remain scarce, mainly because of methodological limitations. Efforts should be pursued both at the metagenomic sample preparation level and on in silico analyses to better understand their roles in the environment and in human/animal health and disease.
authors: Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE) UM63, CNRS 7278, IRD 198, INSERM 1095, Aix-Marseille Université, Marseille, France.
authors: S
authors: S
authors: Halary
authors: Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE) UM63, CNRS 7278, IRD 198, INSERM 1095, Aix-Marseille Université, Marseille, France.
authors: S
authors: S
authors: Temmam
authors: Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE) UM63, CNRS 7278, IRD 198, INSERM 1095, Aix-Marseille Université, Marseille, France.
authors: D
authors: D
authors: Raoult
authors: Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE) UM63, CNRS 7278, IRD 198, INSERM 1095, Aix-Marseille Université, Marseille, France. Electronic address: christelle.desnues@univ-amu.fr.
authors: C
authors: C
authors: Desnues
mesh_terms: D000656:Amoeba / Q000821:virology*; D000818:Animals; D004279:DNA, Viral / Q000235:genetics; D016679:Genome, Viral / Q000235:genetics; D000072139:Giant Viruses / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D056186:Metagenomics / Q000379:methods*
chemical_list: D004279:DNA, Viral