title: Retrospective Single Center Study of Granulocyte Monocyte Adsorption Apheresis Treatment in Inflammatory Bowel Disease.
abstract: Patients with active inflammatory bowel disease (IBD) have elevated and activated myeloid leukocytes, which infiltrate the intestinal mucosa. A significant proportion of IBD patients do not respond adequately to conventional treatment regimes. Studies have suggested that treatment with granulocyte monocyte apheresis (GMA) could be a safe and efficacious alternative for these patients. We evaluated the efficacy and safety of granulocyte/monocyte apheresis in patients with IBD in a retrospective cohort study, conducted from a single center in Stockholm. Clinical details from consecutive apheresis treated patients were retrospectively reviewed from 2004 to 2012. A total of 37 patients were included, 23 patients with ulcerative colitis (UC) and 14 with Crohn's disease (CD). Clinical response was seen in 11 patients (30%) and complete remission in 11 patients (30%). The remission rate was higher in UC patients compared to CD patients, 39% (N = 9) and 14% (N = 2) respectively. A total of 9 patients experienced adverse events. Most frequently reported was headache (N = 4). GMA seems to be a valuable adjuvant treatment regime in the care of patients with refractory IBD.
authors: Gastroenterology Unit, Department of Medicine, Capio St. Goran Hospital, Stockholm, Sweden.
authors: Kajsa
authors: K
authors: Edfors
authors: Gastroenterology Unit, Department of Medicine, Capio St. Goran Hospital, Stockholm, Sweden.
authors: Dagny
authors: D
authors: Ståhlberg
authors: Gastroenterology Unit, Department of Medicine, Capio St. Goran Hospital, Stockholm, Sweden.
authors: Charlotte
authors: C
authors: Söderman
mesh_terms: D000328:Adult; D001781:Blood Component Removal / Q000009:adverse effects / Q000379:methods; D003093:Colitis, Ulcerative / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D003424:Crohn Disease / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006098:Granulocytes; D006801:Humans; D007937:Leukapheresis / Q000379:methods*; D008297:Male; D009000:Monocytes; D012074:Remission Induction / Q000379:methods; D012189:Retrospective Studies; D013548:Sweden; D016896:Treatment Outcome
keywords: Crohn's disease; Granulocyte monocyte adsoption apheresis; Inflammatory bowel disease; Ulcerative colitis