title: Short and Scalable Total Synthesis of Myrioneuron Alkaloids (±)-α,β-Myrifabral A and B.
abstract: The first total synthesis of the Myrioneuron alkaloids (±)-α,β-myrifabral A and B has been accomplished in only four steps from conveniently available starting materials. This short synthesis relied on the use of a key tandem Mannich/amidation reaction to rapidly construct the core framework and two carbon stereocenters. The synthetic route allows for large scale preparation of these promising natural products against the hepatitis C virus (HCV).
authors: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University , Lanzhou 730000, People's Republic of China.
authors: Dengpeng
authors: D
authors: Song
authors: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University , Lanzhou 730000, People's Republic of China.
authors: Zhengshen
authors: Z
authors: Wang
authors: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University , Lanzhou 730000, People's Republic of China.
authors: Ruoming
authors: R
authors: Mei
authors: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University , Lanzhou 730000, People's Republic of China.
authors: Weiwei
authors: W
authors: Zhang
authors: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University , Lanzhou 730000, People's Republic of China.
authors: Donghui
authors: D
authors: Ma
authors: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University , Lanzhou 730000, People's Republic of China.
authors: Dengyu
authors: D
authors: Xu
authors: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University , Lanzhou 730000, People's Republic of China.
authors: Xingang
authors: X
authors: Xie
authors: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University , Lanzhou 730000, People's Republic of China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, People's Republic of China.
authors: Xuegong
authors: X
authors: She
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D016174:Hepacivirus / Q000187:drug effects; D015394:Molecular Structure; D019666:Rubiaceae / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D001688:Biological Products; C000608897:myrifabral A; C000608898:myrifabral B