title: Effects of low level laser therapy on the prognosis of split-thickness skin graft in type 3 burn of diabetic patients: a case series.
abstract: Significant populations in burn centers are diabetic burn patients. Healing process in these patients is more difficult due to diabetes complications. The gold standard treatment for patients with grade 3 burn ulcer is split-thickness skin grafting (STSG), but in the diabetic patients, the rate of graft failure and amputation is high due to impaired tissue perfusion. The technique of low level laser therapy (LLLT) improves tissue perfusion and fibroblast proliferation, increases collagen synthesis, and accelerates wound healing. The purpose of this case report is introducing a new therapeutic method for accelerating healing with better prognosis in these patients. The protocols and informed consent were reviewed according to the Medical Ethics, Board of Shahid Beheshti Medical Sciences (IR.SBMU.RAM.REC.13940.363). Diabetic type 2 patients with 13 grade 3 burn ulcers, candidate for amputation, were enrolled in the study. We used a 650-nm red laser light, 2 J/Cm for the bed of the ulcer and an 810-nm infrared laser light 6 J/Cm(2) for the margins along with intravenous laser therapy with a 660-nm red light, before and after STSG for treating grade 3 burn ulcers in 13 diabetic ulcers. The results of this study showed complete healing in the last 8 weeks for all patients who were candidates for amputation. In this case series, we present 13 cases of diabetic ulcer with type 3 burn wound, candidate for amputation, who healed completely using LLLT and STSG. This is the first time that these two techniques are combined for treatment of burn ulcer in diabetic patients. Using LLLT with STSG might be a promising treatment for burn victims especially diabetic patients.
authors: Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors: Mostafa
authors: M
authors: Dahmardehei
authors: Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran. nooshakazemi@gmail.com.
authors: Nooshafarin
authors: N
authors: Kazemikhoo
authors: Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors: Reza
authors: R
authors: Vaghardoost
authors: Canadian Optic and Laser Center, Victoria, BC, Canada.
authors: Soheila
authors: S
authors: Mokmeli
authors: Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors: Mahnoush
authors: M
authors: Momeni
authors: Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.|Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mohammad Ali
authors: MA
authors: Nilforoushzadeh
authors: Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Fereshteh
authors: F
authors: Ansari
authors: Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Amir
authors: A
authors: Amirkhani
mesh_terms: D000328:Adult; D002056:Burns / Q000532:radiotherapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000532:radiotherapy*; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016038:Skin Transplantation; D014945:Wound Healing / Q000528:radiation effects
keywords: Burn wound; Low level laser therapy; Skin transplantation