title: Genome-wide association study for the interaction between BMR and BMI in obese Korean women including overweight.
abstract: OBJECTIVE
  This is the first study to identify common genetic factors associated with the basal metabolic rate (BMR) and body mass index (BMI) in obese Korean women including overweight. This will be a basic study for future research of obese gene-BMR interaction.
  
  
  METHODS
  The experimental design was 2 by 2 with variables of BMR and BMI. A genome-wide association study (GWAS) of single nucleotide polymorphisms (SNPs) was conducted in the overweight and obesity (BMI > 23 kg/m(2)) compared to the normality, and in women with low BMR (< 1426.3 kcal/day) compared to high BMR. A total of 140 SNPs reached formal genome-wide statistical significance in this study (P < 1 × 10(-4)). Surveys to estimate energy intake using 24-h recall method for three days and questionnaires for family history, a medical examination, and physical activities were conducted.
  
  
  RESULTS
  We found that two NRG3 gene SNPs in the 10q23.1 chromosomal region were highly associated with BMR (rs10786764; P = 8.0 × 10(-7), rs1040675; 2.3 × 10(-6)) and BMI (rs10786764; P = 2.5 × 10(-5), rs10786764; 6.57 × 10(-5)). The other genes related to BMI (HSD52, TMA16, MARCH1, NRG1, NRXN3, and STK4) yielded P <10 × 10(-4). Five new loci associated with BMR and BMI, including NRG3, OR8U8, BCL2L2-PABPN1, PABPN1, and SLC22A17 were identified in obese Korean women (P < 1 × 10(-4)). In the questionnaire investigation, significant differences were found in the number of starvation periods per week, family history of stomach cancer, coffee intake, and trial of weight control in each group.
  
  
  CONCLUSIONS
  We discovered several common BMR- and BMI-related genes using GWAS. Although most of these newly established loci were not previously associated with obesity, they may provide new insights into body weight regulation. Our findings of five common genes associated with BMR and BMI in Koreans will serve as a reference for replication and validation of future studies on the metabolic rate.
authors: Research Institute of Obesity Science, Sungshin Women's University, 55, Dobong-ro 76ga-gil, Gangbuk-gu, Seoul 01133, Korea.; Department of Food and Nutrition, Sungshin Women's University, 55, Dobong-ro 76ga-gil, Gangbuk-gu, Seoul 01133, Korea.
authors: Myoungsook
authors: M
authors: Lee
authors: Nutrition and Metabolism Research Group, Korea Food Research Institute, Gyenggi-do, 13539, Korea.
authors: Dae Young
authors: DY
authors: Kwon
authors: Nutrition and Metabolism Research Group, Korea Food Research Institute, Gyenggi-do, 13539, Korea.
authors: Myung-Sunny
authors: MS
authors: Kim
authors: Research Institute of Obesity Science, Sungshin Women's University, 55, Dobong-ro 76ga-gil, Gangbuk-gu, Seoul 01133, Korea.
authors: Chong Ran
authors: CR
authors: Choi
authors: Research Institute of Obesity Science, Sungshin Women's University, 55, Dobong-ro 76ga-gil, Gangbuk-gu, Seoul 01133, Korea.; Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea.
authors: Mi-Young
authors: MY
authors: Park
authors: Graduate School of Alternative Medicine, Kyonggi University, Seoul 03746, Korea.
authors: Ae-Jung
authors: AJ
authors: Kim
keywords: BMI; BMR; GWAS; obesity