title: Cardiac manifestations in alcoholic liver disease.
abstract: Alcoholic liver disease is the most prevalent cause of progressive liver disease in Europe. Alcoholic cirrhosis occurs in 8%-20% of cases of alcoholic liver disease. It has significant influence on cardiovascular system and haemodynamics through increased heart rate, cardiac output, decreased systemic vascular resistance, arterial pressure and plasma volume expansion. Cirrhotic cardiomyopathy is characterised by systolic and diastolic dysfunction and electrophysiological abnormalities, if no other underlying cardiac disease is present. It is often unmasked only during pharmacological or physiological stress, when compensatory mechanisms of the heart become insufficient to maintain adequate cardiac output. Low-to-moderate intake of alcohol can be cardioprotective. However, heavy drinking is associated with an increased risk of cardiovascular diseases, such as alcoholic cardiomyopathy, arterial hypertension, atrial arrhythmias as well as haemorrhagic and ischaemic stroke. Alcoholic cardiomyopathy is characterised by dilated left ventricle (LV), increased LV mass, normal or reduced LV wall thickness and systolic dysfunction.
authors: Department of Gastroenterology, Internal Medicine Clinic, University Hospital Rijeka, Rijeka, Croatia.
authors: Sandra
authors: S
authors: Milić
authors: Department of Cardiovascular Disease, Internal Medicine Clinic, University Hospital Rijeka, Rijeka, Croatia.
authors: Davorka
authors: D
authors: Lulić
authors: Department of Gastroenterology, Internal Medicine Clinic, University Hospital Rijeka, Rijeka, Croatia.
authors: Davor
authors: D
authors: Štimac
authors: Department of Cardiovascular Disease, Internal Medicine Clinic, University Hospital Rijeka, Rijeka, Croatia.
authors: Alen
authors: A
authors: Ružić
authors: Department of Cardiovascular Disease, Internal Medicine Clinic, University Hospital Rijeka, Rijeka, Croatia.
authors: Luka
authors: L
authors: Zaputović
mesh_terms: D002302:Cardiac Output; D002310:Cardiomyopathy, Alcoholic / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D014655:Vascular Resistance
keywords: Alcoholic cardiomyopathy; Alcoholic liver cirrhosis; Alcoholic liver disease; Cirrhotic cardiomyopathy; Hemodynamics