title: Temporal Course of Dynamic Cerebral Autoregulation in Patients With Intracerebral Hemorrhage.
abstract: OBJECTIVE
  Cerebral autoregulation is crucial in patients with intracerebral hemorrhage. Dynamic cerebral autoregulation is probably altered in acute intracerebral hemorrhage; however, the temporal course of dynamic cerebral autoregulation and its correlation with clinical factors and outcomes are poorly understood.
  
  
  METHODS
  Forty-three acute supratentorial intracerebral hemorrhage patients (53.7±10.0 years old, 30 men) were enrolled for serial measurements performed on days 1 to 2, 4 to 6, 10 to 12, and 30 days after ictus. Noninvasive continuous cerebral blood flow velocity and arterial blood pressure were recorded simultaneously using transcranial Doppler and a servo-controlled plethysmograph, respectively. Transfer function analysis was used to derive the autoregulatory parameters, including phase difference (PD), gain, and the rate of recovery of cerebral blood flow velocity. Results were compared with healthy controls and correlated with clinical factors and the 90-day outcome.
  
  
  RESULTS
  PD did not differ between affected and unaffected hemispheres over time. A significant lower PD (indicating dynamic cerebral autoregulation impaired) was found in bilateral hemispheres on days 1 to 2, 4 to 6, and 10 to 12, followed by later recovery on day 30. Lower bilateral PD on days 1 to 2 was associated with poorer Glasgow Coma Scale score at that time. Lower affected-side PD on days 4 to 6 was an independent predictive value for a poorer modified Rankin Scale at 90 days.
  
  
  CONCLUSIONS
  In patients with supratentorial intracerebral hemorrhage, dynamic cerebral autoregulation is bilaterally impaired lasting at least 10 to 12 days and recovers within a month. Individual PD value is associated with clinical status at acute stage and affected-side PD on days 4 to 6 can be an independent predictor for clinical outcome.
authors: From the Stroke Center, Department of Neurology (H.M., R.Z., Y.Y.), Neuroscience Center, Department of Neurology (Z.-N.G.), and Center for Neurovascular Ultrasound (Y.X.), the First Hospital of Jilin University, Chang Chun, China; and Institute of Advanced Computing and Digital Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen University Town, Shenzhen, China (J.L.).
authors: Hongyin
authors: H
authors: Ma
authors: From the Stroke Center, Department of Neurology (H.M., R.Z., Y.Y.), Neuroscience Center, Department of Neurology (Z.-N.G.), and Center for Neurovascular Ultrasound (Y.X.), the First Hospital of Jilin University, Chang Chun, China; and Institute of Advanced Computing and Digital Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen University Town, Shenzhen, China (J.L.).
authors: Zhen-Ni
authors: ZN
authors: Guo
authors: From the Stroke Center, Department of Neurology (H.M., R.Z., Y.Y.), Neuroscience Center, Department of Neurology (Z.-N.G.), and Center for Neurovascular Ultrasound (Y.X.), the First Hospital of Jilin University, Chang Chun, China; and Institute of Advanced Computing and Digital Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen University Town, Shenzhen, China (J.L.).
authors: Jia
authors: J
authors: Liu
authors: From the Stroke Center, Department of Neurology (H.M., R.Z., Y.Y.), Neuroscience Center, Department of Neurology (Z.-N.G.), and Center for Neurovascular Ultrasound (Y.X.), the First Hospital of Jilin University, Chang Chun, China; and Institute of Advanced Computing and Digital Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen University Town, Shenzhen, China (J.L.).
authors: Yingqi
authors: Y
authors: Xing
authors: From the Stroke Center, Department of Neurology (H.M., R.Z., Y.Y.), Neuroscience Center, Department of Neurology (Z.-N.G.), and Center for Neurovascular Ultrasound (Y.X.), the First Hospital of Jilin University, Chang Chun, China; and Institute of Advanced Computing and Digital Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen University Town, Shenzhen, China (J.L.).
authors: Ren
authors: R
authors: Zhao
authors: From the Stroke Center, Department of Neurology (H.M., R.Z., Y.Y.), Neuroscience Center, Department of Neurology (Z.-N.G.), and Center for Neurovascular Ultrasound (Y.X.), the First Hospital of Jilin University, Chang Chun, China; and Institute of Advanced Computing and Digital Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen University Town, Shenzhen, China (J.L.). doctoryangyi@163.com.
authors: Yi
authors: Y
authors: Yang
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
keywords: dynamic cerebral autoregulation; intracerebral hemorrhage; transfer function analysis