title: Triglyceride-glucose index (TyG index) in comparison with fasting plasma glucose improved diabetes prediction in patients with normal fasting glucose: The Vascular-Metabolic CUN cohort.
abstract: OBJECTIVE
  We evaluated the potential role of the triglyceride-glucose index (TyG index) as a predictor of diabetes in a White European cohort, and compared it to fasting plasma glucose (FPG) and triglycerides.
  
  
  METHODS
  4820 patients of the Vascular-Metabolic CUN cohort (VMCUN cohort) were examined and followed up for 8.84years (±4.39). We performed a Cox proportional hazard ratio with repeated-measures analyses to assess the risk of developing type 2 diabetes across quartiles of FPG, triglycerides and the TyG index (ln[fasting triglycerides (mg/dl)×fasting plasma glucose (mg/dl)/2]), and plotted a receiver operating characteristics (ROC) curve for discrimination.
  
  
  RESULTS
  There were 332 incident cases of type 2 diabetes involving 43,197.32person-years of follow-up. We observed a progressively increased risk of diabetes in subjects with TyG index levels of 8.31 or more. Among those with normal fasting glucose at baseline, <100mg/dl, subjects with the TyG index in the fourth quartile were 6.87 times more likely to develop diabetes (95% CI, 2.76-16.85; P for trend<0.001), as compared with the bottom quartile. The areas under the ROC curves (95% CI) were 0.75 (0.70-0.81) for TyG index, 0.66 (0.60-0.72) for FPG and 0.71 (0.65-0.77) for TG, in subjects with normal fasting glucose (p=0.017).
  
  
  CONCLUSIONS
  Our data suggest that the TyG index is useful for the early identification of individuals at risk of type 2 diabetes. The TyG index seems to be a better predictor than FPG or triglycerides of the potential development of type 2 diabetes in normoglycemic patients.
authors: Garcia-Orcoyen Hospital, Navarra Health Service - Osasunbidea, Spain. Electronic address: davidsilos@hotmail.com.
authors: David
authors: D
authors: Navarro-González
authors: Clinic, Navarra Health Service - Osasunbidea, Spain.
authors: Laura
authors: L
authors: Sánchez-Íñigo
authors: Department of Internal Medicine, University of Navarra Clinic, Pamplona, Spain; IdiSNA - Health Research Institute of Navarra, Spain.
authors: Juan
authors: J
authors: Pastrana-Delgado
authors: Department of Occupational Medicine, Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
authors: Alejandro
authors: A
authors: Fernández-Montero
authors: IdiSNA - Health Research Institute of Navarra, Spain; Food Science and Physiology, University of Navarra, Pamplona, Spain; Centre of Biomedical Research in Pathophysiology of Obesity and Nutrition (CIBERObn), Carlos III Hospital, Madrid, Spain.
authors: J Alfredo
authors: JA
authors: Martinez
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis*; D042241:Early Diagnosis; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D014280:Triglycerides
keywords: Glucose; Insulin resistance; Prevention; Risk factor; Triglycerides; Type 2 diabetes