title: Development of composite outcomes for individual patient data (IPD) meta-analysis on the effects of diet and lifestyle in pregnancy: a Delphi survey.
abstract: OBJECTIVE
  To develop maternal, fetal, and neonatal composite outcomes relevant to the evaluation of diet and lifestyle interventions in pregnancy by individual patient data (IPD) meta-analysis.
  
  
  METHODS
  Delphi survey.
  
  
  METHODS
  The International Weight Management in Pregnancy (i-WIP) collaborative network. Sample Twenty-six researchers from the i-WIP collaborative network from 11 countries.
  
  
  METHODS
  A two-generational Delphi survey involving members of the i-WIP collaborative network (26 members in 11 countries) was undertaken to prioritise the individual outcomes for their importance in clinical care. The final components of the composite outcomes were identified using pre-specified criteria.
  
  
  METHODS
  Composite outcomes considered to be important for the evaluation of the effect of diet and lifestyle in pregnancy.
  
  
  RESULTS
  Of the 36 maternal outcomes, nine were prioritised and the following were included in the final composite: pre-eclampsia or pregnancy-induced hypertension, gestational diabetes mellitus (GDM), elective or emergency caesarean section, and preterm delivery. Of the 27 fetal and neonatal outcomes, nine were further evaluated, with the final composite consisting of intrauterine death, small for gestational age, large for gestational age, and admission to a neonatal intensive care unit (NICU).
  
  
  CONCLUSIONS
  Our work has identified the components of maternal, fetal, and neonatal composite outcomes required for the assessment of diet and lifestyle interventions in pregnancy by IPD meta-analysis.
authors: Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK.|Multidisciplinary Evidence Synthesis Hub (mEsh), Barts and the London School of Medicine and Dentistry Queen Mary University London, London, UK.
authors: E
authors: E
authors: Rogozinska
authors: Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK.
authors: M I
authors: MI
authors: D'Amico
authors: Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK.|Multidisciplinary Evidence Synthesis Hub (mEsh), Barts and the London School of Medicine and Dentistry Queen Mary University London, London, UK.
authors: K S
authors: KS
authors: Khan
authors: Department of Obstetrics and Gynaecology, School of Medical sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors: J G
authors: JG
authors: Cecatti
authors: Monash Centre for Health Research and Implementation (MCHRI), School of Public Health, Monash University, Melbourne, Australia.
authors: H
authors: H
authors: Teede
authors: School of Nursing, University of North Carolina at Chapel Hill, North Carolina, USA.
authors: S
authors: S
authors: Yeo
authors: Department of Gynaecology and Obstetrics, Department of Obstetrics, Odense University Hospital, Odense, Denmark.|University of Southern Denmark, Odense, Denmark.
authors: C A
authors: CA
authors: Vinter
authors: Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK.
authors: G
authors: G
authors: Rayanagoudar
authors: Facultad de Ciencias de la Actividad Fısica y del Deporte-INEF, Universidad Politecnica de Madrid, Madrid, Spain.
authors: R
authors: R
authors: Barakat
authors: Facultad de Ciencias de la Actividad Fısica y del Deporte-INEF, Universidad Politecnica de Madrid, Madrid, Spain.
authors: M
authors: M
authors: Perales
authors: Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, Australia.
authors: J M
authors: JM
authors: Dodd
authors: Division of Mother and Child, Department of Obstetrics and Gynaecology, University Colleges Leuven-Limburg, Hasselt and University Hospitals KU Leuven, Leuven, Belgium.
authors: R
authors: R
authors: Devlieger
authors: Division of Mother and Child, Department of Obstetrics and Gynaecology, University Colleges Leuven-Limburg, Hasselt and University Hospitals KU Leuven, Leuven, Belgium.
authors: A
authors: A
authors: Bogaerts
authors: Department of Public and Occupational Health, EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
authors: M N M
authors: MN
authors: van Poppel
authors: Norwegian School of Sport Sciences, Department of Sports Medicine, Oslo, Norway.
authors: L
authors: L
authors: Haakstad
authors: Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
authors: G X
authors: GX
authors: Shen
authors: Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia.
authors: A
authors: A
authors: Shub
authors: UKK Institute for Health Promotion Research, Tampere, Finland.
authors: R
authors: R
authors: Luoto
authors: School of Health Sciences, University of Tampere, Tampere, Finland.
authors: T I
authors: TI
authors: Kinnunen
authors: Kinesiology Department, California Polytechnic State University, San Luis Obispo, California, USA.
authors: S
authors: S
authors: Phelan
authors: Division of Women's Health, Women's Health Academic Centre, King's College London, St Thomas' Hospital, London, UK.
authors: L
authors: L
authors: Poston
authors: Department of Health Sciences, Physical Therapy Course, S'o Paulo Federal University/Unifesp, Santos, Brazil.
authors: T T
authors: TT
authors: Scudeller
authors: Department of Obstetrics and Gynaecology, Alexandria University, Alexandria, Egypt.
authors: N
authors: N
authors: El Beltagy
authors: Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.|Clinical Services, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors: S N
authors: SN
authors: Stafne
authors: Department of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway.
authors: S
authors: S
authors: Tonstad
authors: Nutritional Research Unit, Copenhagen University Hospital Herlev, Denmark.
authors: N R W
authors: NR
authors: Geiker
authors: Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, the Netherlands.|Department of Obstetrics and Gynaecology, Faculty of Medicine, VU University Medical Centre, Amsterdam, the Netherlands.
authors: A E
authors: AE
authors: Ruifrok
authors: Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Australia.
authors: B W
authors: BW
authors: Mol
authors: School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
authors: A
authors: A
authors: Coomarasamy
authors: Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK.|Multidisciplinary Evidence Synthesis Hub (mEsh), Barts and the London School of Medicine and Dentistry Queen Mary University London, London, UK.
authors: S
authors: S
authors: Thangaratinam
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data*; D003697:Delphi Technique; D016640:Diabetes, Gestational / Q000453:epidemiology* / Q000209:etiology; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008019:Life Style; D009765:Obesity / Q000150:complications / Q000517:prevention & control*; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000517:prevention & control*; D011256:Pregnancy Outcome; D037841:Pregnant People; D047928:Premature Birth / Q000453:epidemiology / Q000209:etiology*; D015430:Weight Gain
keywords: Composite outcome; Delphi survey; diet; fetal; lifestyle; maternal; neonatal