title: Actinic Prurigo.
abstract: Actinic prurigo is an idiopathic photodermatosis that affects the skin, as well as the labial and conjunctival mucosa in indigenous and mestizo populations of Latin America. It starts predominantly in childhood, has a chronic course, and is exacerbated with solar exposure. Little is known of its pathophysiology, including the known mechanisms of the participation of HLA-DR4 and an abnormal immunologic response with increase of T CD4+ lymphocytes. The presence of IgE, eosinophils, and mast cells suggests that it is a hypersensitivity reaction (likely type IVa or b). The diagnosis is clinical, and the presence of lymphoid follicles in the mucosal histopathologic study of mucosa is pathognomonic. The best available treatment to date is thalidomide, despite its secondary effects.
authors: Dermatology Department, Hospital General Dr. Manuel Gea González, México DF, Mexico; drardzcarreon@gmail.com.
authors: Alma Angélica
authors: AA
authors: Rodríguez-Carreón
authors: Dermatology Department, Hospital General Dr. Manuel Gea González, México DF, Mexico.
authors: Erika
authors: E
authors: Rodríguez-Lobato
authors: Dermatology Department, Hospital General Dr. Manuel Gea González, México DF, Mexico.
authors: Georgina
authors: G
authors: Rodríguez-Gutiérrez
authors: Dermatology Department, Hospital General Dr. Manuel Gea González, México DF, Mexico.
authors: Juan Carlos
authors: JC
authors: Cuevas-González
authors: Dermatology Department, Hospital General Dr. Manuel Gea González, México DF, Mexico.
authors: Alexandra
authors: A
authors: Mancheno-Valencia
authors: Dermatology Department, Hospital General Dr. Manuel Gea González, México DF, Mexico.
authors: Martha Patricia
authors: MP
authors: Solís-Arias
authors: Dermatology Department, Hospital General Dr. Manuel Gea González, México DF, Mexico.
authors: María Elisa
authors: ME
authors: Vega-Memije
authors: Dermatology Department, Hospital General Dr. Manuel Gea González, México DF, Mexico.
authors: María Teresa
authors: MT
authors: Hojyo-Tomoka
authors: Dermatology Department, Hospital General Dr. Manuel Gea González, México DF, Mexico.
authors: Luciano
authors: L
authors: Domínguez-Soto
mesh_terms: D003879:Dermatologic Agents / Q000627:therapeutic use*; D015804:HLA-DR4 Antigen / Q000235:genetics; D006801:Humans; D010787:Photosensitivity Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D012873:Skin Diseases, Genetic / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D013472:Sunlight / Q000009:adverse effects; D013792:Thalidomide / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D003879:Dermatologic Agents; D015804:HLA-DR4 Antigen; D013792:Thalidomide