title: Giant Cavernous Hepatic Hemangioma Diagnosed Incidentally in a Perimenopausal Obese Female with Endometrial Adenocarcinoma: A Case Report.
abstract: Hemangiomas are the most common benign tumors of the liver, considered giant when they exceed 50-100 mm in diameter. In the present report, we present a case of a 5.2-kg hemangioma of the right hepatic lobe, with hemangiomatous foci in the left lobe, which was incidentally diagnosed in a 53-year-old obese female hospitalized for uterine bleeding. The computed tomographic scan and physical examination revealed a giant abdominal tumor and hepatic hemangioma of the right hepatic lobe was suspected. Right hepatectomy and total hysterectomy with bilateral ovariectomy was performed. The histological examination of the surgical specimens confirmed the extremely giant cavernous hepatic hemangioma, and a synchronous pT1a endometrioid endometrial adenocarcinoma was also diagnosed. The patient remains alive without postoperative disorders, 6 months after surgery. To our knowledge, this is the first reported case of such huge hemangioma incidentally diagnosed in an obese female, with a synchronous endometrial adenocarcinoma of the uterus. Because obesity may cause hyperestrogenism, it might both increase the growth rate of hemangioma and the genesis of endometrial cancer in perimenopausal females.
authors: Department of Surgery, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania.
authors: Tivadar
authors: T
authors: Bara
authors: Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania simonagurzu@yahoo.com.
authors: Simona
authors: S
authors: Gurzu
authors: Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania.
authors: Ioan
authors: I
authors: Jung
authors: Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania.
authors: Mircea
authors: M
authors: Muresan
authors: Department of Intensive Care, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania simonagurzu@yahoo.com.
authors: Janos
authors: J
authors: Szederjesi
authors: Department of Surgery, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania.
authors: Tivadar
authors: T
authors: Bara
mesh_terms: D018269:Carcinoma, Endometrioid / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006392:Hemangioma, Cavernous / Q000473:pathology* / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D007044:Hysterectomy; D033162:Incidental Findings; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D009765:Obesity / Q000150:complications* / Q000175:diagnosis; D047648:Perimenopause; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: Endometrioid adenocarcinoma; extremely large hemangioma; liver; massive hemangioma; synchronous tumor; uterus