title: Dual-Functional Nanographene Oxide as Cancer-Targeted Drug-Delivery System to Selectively Induce Cancer-Cell Apoptosis.
abstract: Construction of bioresponsive drug-delivery nanosystems could enhance the anticancer efficacy of anticancer agents and reduce their toxic side effects. Herein, by using transferrin (Tf) as a surface decorator, we constructed a cancer-targeted nanographene oxide (NGO) nanosystem for use in drug delivery. This nanosystem (Tf-NGO@HPIP) drastically enhanced the cellular uptake, retention, and anticancer efficacy of loaded drugs but showed much lower toxicity to normal cells. The nanosystem was internalized through receptor-mediated endocytosis and triggered pH-dependent drug release in acidic environments and in the presence of cellular enzymes. Moreover, Tf-NGO@HPIP effectively induced cancer-cell apoptosis through activation of superoxide-mediated p53 and MAPK pathways along with inactivation of ERK and AKT. Taken together, this study demonstrates a good strategy for the construction of bioresponsive NGO drug-delivery nanosystems and their use as efficient anticancer drug carriers.
authors: Department of Chemistry, Jinan University, Guangzhou, 510631, P.R. China.
authors: Binwei
authors: B
authors: Zhou
authors: Department of Chemistry, Jinan University, Guangzhou, 510631, P.R. China.
authors: Yanyu
authors: Y
authors: Huang
authors: Department of Chemistry, Jinan University, Guangzhou, 510631, P.R. China.
authors: Fang
authors: F
authors: Yang
authors: Department of Chemistry, Jinan University, Guangzhou, 510631, P.R. China.
authors: Wenjie
authors: W
authors: Zheng
authors: Department of Chemistry, Jinan University, Guangzhou, 510631, P.R. China. tchentf@jun.edu.cn.
authors: Tianfeng
authors: T
authors: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D010087:Oxides / Q000737:chemistry; D013329:Structure-Activity Relationship; D014168:Transferrin / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010087:Oxides; D014168:Transferrin; D006108:Graphite
keywords: apoptosis; bioresponsive; drug delivery; graphene; nanotechnology