title: Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits.
abstract: OBJECTIVE
  The aim of this study was to investigate the effects of prostaglandin analogs on blood flow in the ophthalmic artery of clinically healthy rabbits.
  
  
  METHODS
  Fifty-five clinically healthy New Zealand white rabbits were divided into six groups, and the left eyes were treated for four weeks with the preservative benzalkonium chloride (BAK) only or a topical formulation of different prostaglandin analogs (bimatoprost BAK, tafluprost BAK-free, travoprost BAK, travoprost POLYQUAD, and latanoprost BAK). Color Doppler imaging was performed before and after the treatments. The mean values of the peak systolic velocity (PSV) and end diastolic velocity and the resistive index (RI) were calculated. Statistical analysis was performed to compare the differences pre- and post-treatment for each drug and post-treatment among the drugs.
  
  
  RESULTS
  The prostaglandin analogs did not affect PSV. Bimatoprost BAK, travoprost POLYQUAD, and latanoprost BAK did not change RI. Tafluprost BAK-free and travoprost BAK therapy resulted in similar reductions in RI. No significant differences pre- and post-treatment were found when BAK was administered alone.
  
  
  CONCLUSIONS
  The prostaglandin analogs tafluprost BAK-free and travoprost BAK improved blood flow in the ophthalmic artery in healthy New Zealand white rabbits, which suggests that these drugs enhance the prevention of the progression the progression of glaucoma.
authors: Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors: Amália Turner
authors: AT
authors: Giannico
authors: Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors: Leandro
authors: L
authors: Lima
authors: Department of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
authors: Gillian C
authors: GC
authors: Shaw
authors: Instituto Graefe de Oftalmologia, Curitiba, PR, Brazil.
authors: Heloisa H A
authors: HH
authors: Russ
authors: Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors: Tilde Rodrigues
authors: TR
authors: Froes
authors: Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors: Fabiano
authors: F
authors: Montiani-Ferreira
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D000069580:Bimatoprost / Q000494:pharmacology; D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D005901:Glaucoma / Q000517:prevention & control; D000077338:Latanoprost; D008297:Male; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D011817:Rabbits; D011897:Random Allocation; D012016:Reference Values; D015203:Reproducibility of Results; D000069557:Travoprost / Q000494:pharmacology; D018615:Ultrasonography, Doppler, Color; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D000959:Antihypertensive Agents; D001548:Benzalkonium Compounds; D011310:Preservatives, Pharmaceutical; D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic; C485333:tafluprost; D000077338:Latanoprost; D000069580:Bimatoprost; D000069557:Travoprost