title: Cardiac Protective Effects of Moringa oleifera Seeds in Spontaneous Hypertensive Rats.
abstract: Hypertension is characterized by a maintained high blood pressure leading to cardiac complications such as left ventricular hypertrophy and fibrosis and an increased risk of heart failure and myocardial infarction. This study investigated the cardiac effects of oral administration of Moringa oleifera (MOI) seed powder in spontaneous hypertensive rats (SHR).
  
  
  
  SHR received food containing MOI seed powder (750mg/d, 8 weeks) or normal food. In vivo measurement of hemodynamic parameters by telemetry and cardiac structure and function analysis by echocardiography were performed. Histological studies were performed to determine fibrosis and protein expression.
  
  
  
  MOI treatment did not modify blood pressure in SHR but reduced nocturnal heart rate and improved cardiac diastolic function (reduction of isovolumetric relaxation time and deceleration time of the E wave, increase of ejection volume and cardiac output compared to nontreated SHR). Left ventricular anterior wall thickness, interseptal thickness on diastole, and relative wall thickness were reduced after MOI treatment. Furthermore, we found a significant reduction of fibrosis in the left ventricle of MOI-treated SHR. This antihypertrophic and antifibrotic effect of MOI was associated with increased expression of peroxisome proliferator-activated receptor (PPAR)-α and δ, reduced cardiac triglyceride level, and enhanced plasmatic prostacyclins.
  
  
  
  Our data show a beneficial effect of MOI on the cardiac structure and function in SHR associated with an upregulation of PPAR-α and δ signaling. This study thus provides scientific rational support for the empirical use of MOI in the traditional Malagasy medicine against cardiac diseases associated with blood pressure overload.
authors: Joseph I
authors: JI
authors: Randriamboavonjy
authors: Gervaise
authors: G
authors: Loirand
authors: INSERM, UMR S1087-CNRS UMR C6291, Nantes, France; Université de Nantes, Nantes, France;
authors: Nathalie
authors: N
authors: Vaillant
authors: INSERM, UMR S1087-CNRS UMR C6291, Nantes, France; Université de Nantes, Nantes, France;
authors: Benjamin
authors: B
authors: Lauzier
authors: EA 921 SONAS, SFR 4207 Campus du Végétal, Angers, France;
authors: Sévérine
authors: S
authors: Derbré
authors: Centre d'Étude des Substances Naturelles (CESN), Lyon, France.
authors: Serge
authors: S
authors: Michalet
authors: INSERM, UMR S1087-CNRS UMR C6291, Nantes, France; Université de Nantes, Nantes, France;
authors: Pierre
authors: P
authors: Pacaud
authors: INSERM, UMR S1087-CNRS UMR C6291, Nantes, France; Université de Nantes, Nantes, France; angela.tesse@univ-nantes.fr gervaise.loirand@univ-nantes.fr.
authors: Angela
authors: A
authors: Tesse
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004452:Echocardiography; D006331:Heart Diseases / Q000209:etiology / Q000517:prevention & control*; D006339:Heart Rate; D006973:Hypertension / Q000150:complications*; D050356:Lipid Metabolism; D008297:Male; D029588:Moringa oleifera; D009206:Myocardium / Q000378:metabolism; D047493:PPAR alpha / Q000378:metabolism; D047494:PPAR delta / Q000378:metabolism; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012639:Seeds
chemical_list: D047493:PPAR alpha; D047494:PPAR delta; D028321:Plant Preparations
keywords: blood pressure; cardiac hypertrophy; fibrosis; hypertension.