title: AID hits the jackpot when missing the target.
abstract: Activation induced deaminase is the single B cell specific factor mediating class switch recombination and somatic hypermutation. Numerous studies have shown that AID preferentially targets Ig substrates and also attacks non-Ig substrates to create DNA damage that contributes to lymphomagenesis. AID targeting to Ig loci is linked to transcription but the mechanism governing this process has been obscure. Here we discuss research that illustrates the connection between AID targeting to DNA substrates and transcription processes to reveal rules governing the specificity of AID attack. These observations are woven together to provide a integrated view of AID function and a surprising linkage with global regulation of gene expression.
authors: Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA. Electronic address: star1@uic.edu.
authors: Amy L
authors: AL
authors: Kenter
authors: Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA.
authors: Satyendra
authors: S
authors: Kumar
authors: Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA.
authors: Robert
authors: R
authors: Wuerffel
authors: Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, USA.
authors: Fernando
authors: F
authors: Grigera
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology*; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism*; D019175:DNA Methylation; D006801:Humans; D017578:Immunoglobulin Class Switching / Q000502:physiology; D027041:Somatic Hypermutation, Immunoglobulin / Q000502:physiology; D014158:Transcription, Genetic; D014178:Translocation, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
chemical_list: D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase