title: Increased asymmetric dimethylarginine levels in severe transient tachypnea of the newborn.
abstract: Nitric oxide (NO) is synthesized by NO synthase (NOS), and asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. We aimed to investigate l-arginine and ADMA levels in transient tachypnea of the newborn (TTN) and their relationship with systolic pulmonary artery pressure (PAP) and disease severity.
  
  
  
  Infants born at ⩾35 weeks gestational age with clinical signs and chest X-ray findings consistent with TTN were enrolled; controls were recruited at the same time. l-arginine and ADMA levels were measured at 12 to 24 h (first samples) and at 48 to 72 h (second samples). Systolic PAP was evaluated on the second day. Patients were divided according to the duration of tachypnea and designated as group A (duration ⩽72 h) and group B (duration >72 h).
  
  
  
  In the first samples, the ADMA levels were significantly higher in patients with TTN compared with controls (P<0.001). In the second samples, the ADMA levels were significantly higher in group B compared with that in group A (P=0.019). In group A patients, the second ADMA levels were significantly lower compared with that in the first samples (P<0.001), whereas the second ADMA levels remained unchanged compared with the first samples in group B. Systolic PAP values were significantly higher in group B compared with that in group A patients (P=0.033).
  
  
  
  Increased ADMA concentration may reduce NO synthesis, leading to increased PAP and thus longer duration of tachypnea.
authors: Neonatal Intensive Care Unit, Department of Neonatology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Ankara, Turkey.
authors: D U
authors: DU
authors: Isik
authors: Neonatal Intensive Care Unit, Department of Neonatology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Ankara, Turkey.
authors: A Y
authors: AY
authors: Bas
authors: Neonatal Intensive Care Unit, Department of Neonatology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Ankara, Turkey.
authors: N
authors: N
authors: Demirel
authors: Neonatal Intensive Care Unit, Department of Neonatology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Ankara, Turkey.
authors: S
authors: S
authors: Kavurt
authors: Neonatal Intensive Care Unit, Department of Neonatology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Ankara, Turkey.
authors: O
authors: O
authors: Aydemir
authors: Department of Pediatric Cardiology, Türkiye Yüksek İhtisas Education and Research Hospital, Ankara, Turkey.
authors: A V
authors: AV
authors: Kavurt
authors: Department of Pediatric Cardiology, Ankara Children's Hematology Oncology Research and Training Hospital, Ankara, Turkey.
authors: I
authors: I
authors: Cetin
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001794:Blood Pressure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011651:Pulmonary Artery / Q000502:physiology*; D012720:Severity of Illness Index; D013223:Statistics as Topic; D059245:Transient Tachypnea of the Newborn / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D001120:Arginine; D019001:Nitric Oxide Synthase