title: Pharmacokinetics of Paradol Analogues Orally Administered to Rats.
abstract: The kinetics parameters of paradols with different acyl chain lengths have been evaluated to determine their antiobesity site of action. Rats were orally administered olive oil containing 0-, 6-, 8-, or 12-paradol, and blood samples were collected at different time points. The concentrations of the paradols in the plasma were analyzed both with and without β-glucuronidase treatment. The area under the plasma concentration-time curve from 0 to 24 h (AUC(0-24h)) of the parent compounds decreased with increasing acyl chain length. Whereas 12-paradol showed the largest AUC(0-24h) with the longest time to reach its maximum plasma concentration of all of the compounds tested, the AUC(0-24h) values of the metabolites decreased with increasing acyl chain length. These results indicate that increasing acyl chain length leads to a decrease in the absorption of paradols via the intestinal tract, the wall of which was estimated to be their antiobesity site of action.
authors: Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University , 19-1 Nanakuma 8-Chome, Jonan-ku, Fukuoka, Japan 814-0180.
authors: Shuichi
authors: S
authors: Setoguchi
authors: Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University , 19-1 Nanakuma 8-Chome, Jonan-ku, Fukuoka, Japan 814-0180.
authors: Daisuke
authors: D
authors: Watase
authors: Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University , 19-1 Nanakuma 8-Chome, Jonan-ku, Fukuoka, Japan 814-0180.
authors: Nami
authors: N
authors: Nagata-Akaho
authors: Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University , 19-1 Nanakuma 8-Chome, Jonan-ku, Fukuoka, Japan 814-0180.
authors: Akinori
authors: A
authors: Haratake
authors: Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University , 19-1 Nanakuma 8-Chome, Jonan-ku, Fukuoka, Japan 814-0180.
authors: Kazuhisa
authors: K
authors: Matsunaga
authors: Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University , 19-1 Nanakuma 8-Chome, Jonan-ku, Fukuoka, Japan 814-0180.
authors: Jiro
authors: J
authors: Takata
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage; D002396:Catechols; D005233:Fatty Alcohols; D006139:Guaiacol / Q000031:analogs & derivatives / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D007659:Ketones / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D010636:Phenols / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019440:Anti-Obesity Agents; D002396:Catechols; D005233:Fatty Alcohols; D007659:Ketones; D010636:Phenols; C013738:zingerone; D006139:Guaiacol; C007845:gingerol; C421614:6-paradol
keywords: acyl chain length; metabolite; paradol analogue; parent compound; pharmacokinetics