title: In vivo biofunctionalization of titanium patient-specific implants with nano hydroxyapatite and other nano calcium phosphate coatings: A systematic review.
abstract: OBJECTIVE
  To delineate the best procedures for increasing osseointegration in cranio-maxillo-facial surgery using nano-sized calcium phosphate coatings on titanium patient specific implants.
  
  
  METHODS
  A multi-database single-reviewer systematic literature review was conducted.
  
  
  RESULTS
  Twenty-eight papers consisting of twenty-five animal studies and three human studies met the selection criteria. The results of existing literature suggest that titanium implants coated with nano calcium phosphate and hydroxyapatite improves osseointegration and implant fixation. However, not all coating techniques enhance biofunctionalization. Factors including implant microroughness, coating thickness, calcium phosphate solubility, and nanotopography contribute significantly to biofunctionalization. Nonetheless, additional data derived from clinical studies are needed to support this statement, as well as the possible influence of routine autoclaving procedures.
authors: European Face Centre, Universitair Ziekenhuis Brussel/VUB, Belgium.
authors: Alexander
authors: A
authors: Bral
authors: European Face Centre, Universitair Ziekenhuis Brussel/VUB, Belgium. Electronic address: Maurice.Mommaerts@uzbrussel.be.
authors: Maurice Y
authors: MY
authors: Mommaerts
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017886:Durapatite; D006801:Humans; D053758:Nanoparticles; D016348:Osseointegration / Q000187:drug effects*; D013499:Surface Properties; D014025:Titanium / Q000494:pharmacology
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D017886:Durapatite; D014025:Titanium
keywords: Calcium phosphate; Hydroxyapatite; Implant; Nanoparticles; Titanium