title: The effects of motor rehabilitation training on clinical symptoms and serum BDNF levels in Parkinson's disease subjects.
abstract: Increasing evidence suggests that motor rehabilitation may delay Parkinson's disease (PD) progression. Moreover, parallel treatments in animals up-regulate brain-derived neurotrophic factor (BDNF). Thus, we investigated the effect of a motor rehabilitation protocol on PD symptoms and BDNF serum levels. Motor rehabilitation training consisted of a cycle of 20 days/month of physiotherapy divided in 3 daily sessions. Clinical data were collected at the beginning, at the end, and at 90 days follow-up. BDNF serum levels were detected by ELISA at 0, 7, 14, 21, 30, and 90 days. The follow-up period had a duration of 60 days (T30-T90). The results showed that at the end of the treatment (day 30), an improvement in extrapyramidal signs (UPDRS III; UPDRS III - Gait and Balance items), motor (6 Minute Walking Test), and daily living activities (UPDRS II; PDQ-39) was observed. BDNF levels were increased at day 7 as compared with baseline. After that, no changes in BDNF were observed during the treatment and in the successive follow-up. This study demonstrates that motor rehabilitation training is able to ameliorate PD symptoms and to increase temporarily BDNF serum levels. The latter effect may potentially contribute to the therapeutic action.
authors: a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
authors: Francesco
authors: F
authors: Angelucci
authors: a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
authors: Jacopo
authors: J
authors: Piermaria
authors: a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.|b Department of Systemic Medicine, "Tor Vergata" University, Via Montpellier 1, 00133 Rome, Italy.
authors: Francesca
authors: F
authors: Gelfo
authors: a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
authors: Jacob
authors: J
authors: Shofany
authors: a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
authors: Marco
authors: M
authors: Tramontano
authors: c Institute of Cellular Biology and Neurobiology, CNR, Via del Fosso di Fiorano 64, 00143 Rome, Italy.
authors: Marco
authors: M
authors: Fiore
authors: a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.|b Department of Systemic Medicine, "Tor Vergata" University, Via Montpellier 1, 00133 Rome, Italy.
authors: Carlo
authors: C
authors: Caltagirone
authors: a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy.
authors: Antonella
authors: A
authors: Peppe
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005260:Female; D005684:Gait / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010300:Parkinson Disease / Q000097:blood* / Q000503:physiopathology*; D026741:Physical Therapy Modalities; D013663:Teaching; D015854:Up-Regulation / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: BDNF; Parkinson’s disease; exercice physique; maladie de Parkinson; motor rehabilitation; physical exercise; rééducation motrice