title: The core of hepatitis C virus pathogenesis.
abstract: Capsid proteins form protective shells around viral genomes and mediate viral entry. However, many capsid proteins have additional and important roles for virus infection and in modulating cellular response to infection, with important consequences on pathogenesis. Infection by the Hepatitis C virus (HCV) can lead to liver steatosis, cirrhosis, and hepatocellular carcinoma. Herein, we focus on the role in pathogenesis of Core, the capsid protein of the HCV.
authors: Dept of Molecular & Cellular Biochemistry, Indiana University, Bloomington, IN 47405, United States. Electronic address: ckao@indiana.edu.
authors: C Cheng
authors: CC
authors: Kao
authors: Dept of Molecular & Cellular Biochemistry, Indiana University, Bloomington, IN 47405, United States.
authors: Guanghui
authors: G
authors: Yi
authors: Inst. of Biomedical Informatics, National Yang-Ming University, Taipei 11221, Taiwan.
authors: Hsuan-Cheng
authors: HC
authors: Huang
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000821:virology; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006526:Hepatitis C / Q000821:virology*; D006801:Humans; D008103:Liver Cirrhosis / Q000821:virology; D008113:Liver Neoplasms / Q000821:virology; D051379:Mice; D014758:Viral Core Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D036022:Capsid Proteins; D014758:Viral Core Proteins