title: [TEMPORAL ORDER DETERIORATION AND CIRCADIAN DISRUPTION WITH AGE].
abstract: The present review summarizes the current knowledge of gradual deterioration of temporal order in aging humans and other mammals. An obvious consequence of age-dependent circadian disruption in complex mechanisms is extra-circadian dissemination (ECD) that can be observed in overt rhythmic functions. ECD is a variance transposition from circadian to ultradian and infradian frequencies accompanied by a loss of interdaily phase stability. Moreover, heterochronic changes in central and peripheral tissue-specific cellular mechanisms are involved in circadian desychronization. A multitude of internal factors accounts for cumulative clockwork misalignment. Age-related circadian disruption is a consequence of weaker rhythm generation and the loss of proper orchestration on molecular, tissue and systemic levels, disabling their circadian synchrony and resonance.
authors: D G
authors: DG
authors: Gubin
authors: D
authors: D
authors: Weinert
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002940:Circadian Rhythm; D006801:Humans