title: Four complement factor H gene polymorphisms in association with AMD: A meta-analysis.
abstract: OBJECTIVE
  To investigate the possible association between CFH gene polymorphisms -543G>A (rs1410996), A473A (rs2274700), -257C>T (rs3753394), IVS15 (rs1329428) and AMD risk.
  
  
  METHODS
  We searched the published literature in the Medline and Scopus from inception to May 2015. A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0, and the Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated in fixed or random effect model based on heterogeneity test among studies.
  
  
  RESULTS
  Nineteen studies with a total of 10,676 subjects were included in the present meta-analysis. A statistical significant association was observed between AMD risk and CFH -543G>A polymorphism with OR of 1.77 (95% CI, 1.47-2.12), 2.24 (95% CI, 1.71-2.94), 0.49 (95% CI, 0.38-0.62) and 0.25 (95% CI, 0.18-0.37) in additive, dominant, recessive and codominant models, respectively. Similar results were obtained in polymorphisms A473A, -257C>T, IVS15. Furthermore, stratified analysis for ethnicity showed a significantly strong association between -543G>A, A473A polymorphisms and AMD risk.
  
  
  CONCLUSIONS
  The present meta-analysis suggested that CFH -543G>A, A473A, -257C>T, and IVS15 polymorphisms might be moderately associated with AMD risk. This conclusion warrants confirmation by further studies.
authors: Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, Sichuan Province, China; Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637007, Sichuan Province, China.
authors: Xuan
authors: X
authors: Liao
authors: Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, Sichuan Province, China; Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637007, Sichuan Province, China. Electronic address: eyelanchangjun@163.com.
authors: Chang-Jun
authors: CJ
authors: Lan
authors: Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hunghom, Hong Kong, China.
authors: Isabella-Wai-Yin
authors: IW
authors: Cheuk
authors: Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, Sichuan Province, China; Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637007, Sichuan Province, China.
authors: Qing-qing
authors: QQ
authors: Tan
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D017242:Complement Factor H / Q000235:genetics*; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D017242:Complement Factor H
keywords: Complement factor H; Macular degeneration; Meta-analysis; Polymorphism