title: Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.
abstract: Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation.
authors: Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, Vermont, 05405, United States of America.
authors: J Matthew
authors: JM
authors: Mahoney
authors: Department of Neurosurgery, University of California Los Angeles, Los Angeles, California, 90095, United States of America.
authors: Ali S
authors: AS
authors: Titiz
authors: Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, Vermont, 05405, United States of America.
authors: Amanda E
authors: AE
authors: Hernan
authors: Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, Vermont, 05405, United States of America.|Neurosciences Unit, University College London Institute of Child Health, London, United Kingdom.
authors: Rod C
authors: RC
authors: Scott
mesh_terms: D000200:Action Potentials; D000818:Animals; D001522:Behavior, Animal; D001931:Brain Mapping; D003071:Cognition; D004566:Electrodes; D004569:Electroencephalography; D004576:Electromyography; D006624:Hippocampus / Q000502:physiology*; D016013:Likelihood Functions; D008297:Male; D008390:Markov Chains; D008568:Memory; D008959:Models, Neurological; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000502:physiology*; D013997:Time Factors