title: Parathyroid hormone and the risk of incident hypertension: the Atherosclerosis Risk in Communities study.
abstract: BACKGROUND
  Recent evidence suggests that parathyroid hormone (PTH) has effects on vascular smooth muscle cells, the rennin-angiotensin system and kidney function, but less is known about its role in the development of hypertension. The distribution of serum PTH also varies by race.
  
  
  RESULTS
  Therefore, we examined the relation between PTH and incident hypertension and tested for interaction by race among 7504 Atherosclerosis Risk in Communities participants (1264 black, 6240 white, median age 56 years) without initial hypertension in 1990-1992. During a median follow-up of 6 years, 1487 white and 509 black participants developed hypertension. In the overall study population, PTH was not associated with incident hypertension after adjustment for demographics and behavioral risk factors [hazard ratio highest vs. lowest quintiles, 95% confidence interval: 1.11 (0.96-1.28); P for linear trend 0.02]. Although the interaction was not statistically significant (P = 0.60), there was some evidence that the PTH-hypertension association differed by race. Among blacks, PTH was positively associated with incident hypertension, independent of demographics, and behavioral risk factors (P for linear trend 0.003). Among whites, PTH was not associated with hypertension risk. Results were similar when comparing participants with elevated versus nonelevated PTH (≥65 vs. <65 pg/ml): hazard ratio in blacks: 1.24 (1.02-1.54); hazard ratio in whites: 0.95 (0.78-1.16).
  
  
  CONCLUSIONS
  In this large community-based cohort, PTH levels, overall, were not independently associated with the risk of hypertension. However, we found some evidence that PTH may be associated with hypertension in blacks. Future research should continue to explore potential race differences in the PTH-hypertension association.
authors: aDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MinnesotabDepartments of Epidemiology and MedicinecDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
authors: Lu
authors: L
authors: Yao
authors: Aaron R
authors: AR
authors: Folsom
authors: James S
authors: JS
authors: Pankow
authors: Elizabeth
authors: E
authors: Selvin
authors: Erin D
authors: ED
authors: Michos
authors: Alvaro
authors: A
authors: Alonso
authors: Weihong
authors: W
authors: Tang
authors: Pamela L
authors: PL
authors: Lutsey
mesh_terms: D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D016016:Proportional Hazards Models; D012111:Residence Characteristics; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data*
chemical_list: D010281:Parathyroid Hormone