title: Direct Regioselective γ-Amination of Enones.
abstract: Carbonyl compounds bearing a γ-amino group are valuable pharmacologically active targets. Regioselective γ-C-N bond formation is achieved with simple enone substrates through controlled dienolate reactivity toward azodicarboxylate electrophiles. The amination reaction occurs readily with sterically demanding nucleophiles and is stereoselective.
authors: Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607, United States.
authors: Xiaohong
authors: X
authors: Chen
authors: Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607, United States.
authors: Xiaoguang
authors: X
authors: Liu
authors: Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607, United States.
authors: Justin T
authors: JT
authors: Mohr
mesh_terms: D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D009584:Nitrogen