title: Morphometric human embryonic brain features according to developmental stage.
abstract: OBJECTIVE
  The present study investigated linear, area, and volume measurements of human brain samples according to Carnegie stages (CS) in an attempt to select suitable morphometric features that reflect embryonic development.
  
  
  METHODS
  Using magnetic resonance imaging, we measured seven linear segments, three separate areas, and three regional volumes in 101 samples between CS13 and 23. Brain volume was determined via manual segmentation of the magnetic resonance image, whereby a formula was generated to estimate the volume of each linear measurement.
  
  
  RESULTS
  All parameters correlated with crown-rump length. Bitemporal length and mesencephalic height increased linearly according to the CS, and a high correlation between bitemporal length and both whole-brain (r = 0.98) and prosencephalon (r = 0.99) volumes was found when brain cavity volume was excluded.
  
  
  CONCLUSIONS
  Morphometric data related to human embryonic stages are valuable for correcting and comparing sonographic data. The present approach may contribute to improvements in prenatal diagnostics by enabling the selection of more suitable measurements during early embryonic stages. © 2016 John Wiley & Sons, Ltd.
authors: Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Ami
authors: A
authors: Kobayashi
authors: Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Koichi
authors: K
authors: Ishizu
authors: Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.|Congenital Anomaly Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Shigehito
authors: S
authors: Yamada
authors: Congenital Anomaly Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Chigako
authors: C
authors: Uwabe
authors: Institute of Applied Physics, University of Tsukuba, Ibaragi, Japan.
authors: Katsumi
authors: K
authors: Kose
authors: Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Tetsuya
authors: T
authors: Takakuwa
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000196:embryology*; D047108:Embryonic Development; D006801:Humans; D008279:Magnetic Resonance Imaging; D012016:Reference Values