title: Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study.
abstract: Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with chronic kidney disease (CKD). In this study, we examined the association between inflammation and AF in 3,762 adults with CKD, enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study. AF was determined at baseline by self-report and electrocardiogram (ECG). Plasma concentrations of interleukin(IL)-1, IL-1 Receptor antagonist, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor-β, high sensitivity C-Reactive protein, and fibrinogen, measured at baseline. At baseline, 642 subjects had history of AF, but only 44 had AF in ECG recording. During a mean follow-up of 3.7 years, 108 subjects developed new-onset AF. There was no significant association between inflammatory biomarkers and past history of AF. After adjustment for demographic characteristics, comorbid conditions, laboratory values, echocardiographic variables, and medication use, plasma IL-6 level was significantly associated with presence of AF at baseline (Odds ratio [OR], 1.61; 95% confidence interval [CI], 1.21 to 2.14; P = 0.001) and new-onset AF (OR, 1.25; 95% CI, 1.02 to 1.53; P = 0.03). To summarize, plasma IL-6 level is an independent and consistent predictor of AF in patients with CKD.
authors: Biostatistics core, George Washington University Medical Faculty Associates, Washington, DC, United States of America.|George Washington University School of Medicine, Washington, DC, United States of America.
authors: Richard L
authors: RL
authors: Amdur
authors: Division of cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
authors: Monica
authors: M
authors: Mukherjee
authors: Kaiser Permanente Division of Research, Oakland, CA, United States of America.
authors: Alan
authors: A
authors: Go
authors: George Washington University School of Medicine, Washington, DC, United States of America.
authors: Ian R
authors: IR
authors: Barrows
authors: Division of Renal diseases and Hypertension, George Washington University School of Medicine, Washington, DC, United States of America.
authors: Ali
authors: A
authors: Ramezani
authors: Division of Renal diseases and Hypertension, George Washington University School of Medicine, Washington, DC, United States of America.
authors: Jun
authors: J
authors: Shoji
authors: Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States of America.
authors: Muredach P
authors: MP
authors: Reilly
authors: Bridgeport Hospital, Bridgeport, CT, United States of America.
authors: Joseph
authors: J
authors: Gnanaraj
authors: Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States of America.
authors: Raj
authors: R
authors: Deo
authors: Harvard Medical School, Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
authors: Sylvia
authors: S
authors: Roas
authors: Temple Heart and Vascular Center, Philadelphia, PA, United States of America.
authors: Martin
authors: M
authors: Keane
authors: Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America.
authors: Steve
authors: S
authors: Master
authors: Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America.
authors: Valerie
authors: V
authors: Teal
authors: Wake Forest University School of Medicine, Winston-Salem, NC, United States of America.
authors: Elsayed Z
authors: EZ
authors: Soliman
authors: Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America.
authors: Peter
authors: P
authors: Yang
authors: Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America.
authors: Harold
authors: H
authors: Feldman
authors: National Institute of Diabetes and Digestive and Kidney Diseases, Division of Kidney, Urologic and Hematologic Diseases, Bethesda, MD, United States of America.
authors: John W
authors: JW
authors: Kusek
authors: Division of Cardiology, George Washington University School of Medicine, Washington, DC, United States of America.
authors: Cynthia M
authors: CM
authors: Tracy
authors: Division of Renal diseases and Hypertension, George Washington University School of Medicine, Washington, DC, United States of America.
authors: Dominic S
authors: DS
authors: Raj
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D002097:C-Reactive Protein / Q000378:metabolism; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D012307:Risk Factors; D016212:Transforming Growth Factor beta / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C507763:IL1RN protein, human; C508600:IL6 protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D015850:Interleukin-6; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein