title: Long-term daily vibration exposure alters current perception threshold (CPT) sensitivity and myelinated axons in a rat-tail model of vibration-induced injury.
abstract: Repeated exposure to hand-transmitted vibration through the use of powered hand tools may result in pain and progressive reductions in tactile sensitivity. The goal of the present study was to use an established animal model of vibration-induced injury to characterize changes in sensory nerve function and cellular mechanisms associated with these alterations. Sensory nerve function was assessed weekly using the current perception threshold test and tail-flick analgesia test in male Sprague-Dawley rats exposed to 28 d of tail vibration. After 28 d of exposure, Aβ fiber sensitivity was reduced. This reduction in sensitivity was partly attributed to structural disruption of myelin. In addition, the decrease in sensitivity was also associated with a reduction in myelin basic protein and 2',3'- cyclic nucleotide phosphodiasterase (CNPase) staining in tail nerves, and an increase in circulating calcitonin gene-related peptide (CGRP) concentrations. Changes in Aβ fiber sensitivity and CGRP concentrations may serve as early markers of vibration-induced injury in peripheral nerves. It is conceivable that these markers may be utilized to monitor sensorineural alterations in workers exposed to vibration to potentially prevent additional injury.
authors: a Engineering and Control Technology Branch, Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA.
authors: Kristine
authors: K
authors: Krajnak
authors: b Department of Cell Biology, Neurobiology & Anatomy , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
authors: Sandya G
authors: SG
authors: Raju
authors: a Engineering and Control Technology Branch, Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA.
authors: G Roger
authors: GR
authors: Miller
authors: a Engineering and Control Technology Branch, Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA.
authors: Claud
authors: C
authors: Johnson
authors: a Engineering and Control Technology Branch, Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA.
authors: Stacey
authors: S
authors: Waugh
authors: c Biostatistics and Epidemiology Branch, Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA.
authors: Michael L
authors: ML
authors: Kashon
authors: b Department of Cell Biology, Neurobiology & Anatomy , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
authors: Danny A
authors: DA
authors: Riley
mesh_terms: D000818:Animals; D001369:Axons / Q000473:pathology*; D015740:Calcitonin Gene-Related Peptide / Q000097:blood; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1 / Q000378:metabolism; D004195:Disease Models, Animal; D053421:Hand-Arm Vibration Syndrome / Q000473:pathology*; D008297:Male; D004676:Myelin Basic Protein / Q000378:metabolism; D010525:Peripheral Nerves / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014732:Vibration / Q000009:adverse effects*
chemical_list: D004676:Myelin Basic Protein; D014409:Tumor Necrosis Factor-alpha; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D015740:Calcitonin Gene-Related Peptide