title: [Influence of Polycations on Antibacterial Activity of Lysostaphin].
abstract: The synergistic antibacterial activity of lysostaphin and polycations of different chemical structures against Staphylococcus aureus has been shown. Polycations improved the lytic activity of lysostaphin against the peptidoglycan of staphylococci. It is proposed that this resulted in decreased binding of positively charged lysostaphin with S. aureus cell-wall teichoic acids. These data provide an opportunity to search for polycations that would amplify the synergistic effect of lysostaphin or other antibacterial proteins against staphylococci.
authors: S N
authors: SN
authors: Kulikov
authors: R Z
authors: RZ
authors: Khairullin
authors: V P
authors: VP
authors: Varlamov
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D004357:Drug Synergism; D008248:Lysostaphin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011073:Polyamines / Q000494:pharmacology*; D000071228:Polyelectrolytes; D011094:Polyethyleneimine / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D055672:Static Electricity; D013682:Teichoic Acids / Q000737:chemistry / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D008248:Lysostaphin; D011073:Polyamines; D000071228:Polyelectrolytes; D011094:Polyethyleneimine; D013682:Teichoic Acids; C063994:polyallylamine