title: A new strategy based on electrospray technique to prepare dual-responsive poly(ether urethane) nanogels.
abstract: In this work, we proposed a new strategy based on electrospray technique to prepare nanogels. Compared with other methods of preparing nanogels, electrospray technique is more simple and efficient. A biodegradable and multi-responsive poly(ether urethane) (PEU) was synthesized via a facile one-pot method and used as the electrospray material. By using electrospray technique, pH- and redox-responsive poly(ether urethane) nanogels were prepared. The morphologies of the electrospray nanoparticles before and after swelling were demonstrated to be spherical and uniform, as characterized by scanning electron microscope (SEM) and transmission electron microscopy (TEM). Dynamic light scattering (DLS) results showed that the mean hydrodynamic diameter of nanogels was about 500 nm. The pH- and redox-sensitive behaviors of nanogels were studied with DLS and TEM. In acidic media the nanogels dissociated, while in the presence of GSH the nanogels degraded. The nanogels suspension was stored at 4 °C and was stable without aggregation for at least 30 days. Doxorubicin (DOX) can be further loaded into the poly(ether urethane) nanogels. The electrospray nanogels can change the release rate of loaded drug in response to pH and GSH stimuli.
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: chenjiaming000@126.com.
authors: Jiaming
authors: J
authors: Chen
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: daihf@zju.edu.cn.
authors: Huafeng
authors: H
authors: Dai
authors: Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. Electronic address: 369369@zju.edu.cn.
authors: Hui
authors: H
authors: Lin
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: tukh@zju.edu.cn.
authors: Kehua
authors: K
authors: Tu
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: hjwang@zju.edu.cn.
authors: Hongjun
authors: H
authors: Wang
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: lqwang@zju.edu.cn.
authors: Li-Qun
authors: LQ
authors: Wang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D055664:Electrochemical Techniques / Q000379:methods*; D005978:Glutathione / Q000737:chemistry; D057446:Hydrodynamics; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008027:Light; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010316:Particle Size; D011140:Polyurethanes / Q000737:chemistry*; D012542:Scattering, Radiation
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D011140:Polyurethanes; C115016:polyetherurethane; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D004317:Doxorubicin; D005978:Glutathione
keywords: Electrospray; Nanogels; Physical cross-linking; Poly(ether urethane); pH- and redox-responsive