title: Emollient efficacy and acceptability in the treatment of eczematous dry skin: A double-blind, randomised comparison of two UK-marketed products.
abstract: OBJECTIVE
  The aim of this study was to compare the moisturising efficacy and acceptability of physical characteristics of two commonly prescribed emollients licenced in the UK, Doublebase Dayleve gel (DELP) and Diprobase cream (DIPC).
  
  
  METHODS
  The study was a double-blind, concurrent bi-lateral comparison in female eczema subjects with dry skin.
  
  
  RESULTS
  In Part 1, comparing the area under the curve (AUC) change from baseline corneometer readings over 24 h following single applications of the emollients to the volar forearms of 34 subjects, the AUC for DELP was more than three times that seen for DIPC (p < 0.0001). In Part 2, comparing the same outcome measured over 5 days of twice daily applications to the lower legs in 36 subjects, the AUC for DELP was approximately five times that for DIPC (p < 0.0001). 69% of subjects "Like Slightly" or "Like Strongly" DELP compared to 33% for DIPC (p = 0.025). 72% indicated they would use DELP again compared to 33% for DIPC (p = 0.033). 75% of subjects preferred DELP, 17% preferred DIPC and 8% expressed no preference (p = 0.0004).
authors: a Dermal Laboratories Ltd , Hitchin , UK and.
authors: Jasmina
authors: J
authors: Djokic-Gallagher
authors: a Dermal Laboratories Ltd , Hitchin , UK and.
authors: Philip
authors: P
authors: Rosher
authors: a Dermal Laboratories Ltd , Hitchin , UK and.
authors: Jennine
authors: J
authors: Walker
authors: a Dermal Laboratories Ltd , Hitchin , UK and.
authors: Krystyna
authors: K
authors: Sykes
authors: b Reading Science Centre, Reading Scientific Services Ltd , Reading , UK.
authors: Valerie
authors: V
authors: Hart
mesh_terms: D019540:Area Under Curve; D004311:Double-Blind Method; D004485:Eczema / Q000188:drug therapy*; D004643:Emollients / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009930:Organic Chemicals / Q000627:therapeutic use; D057240:Patient Preference; D016896:Treatment Outcome; D006113:United Kingdom
chemical_list: C461579:Doublebase; D004643:Emollients; D009930:Organic Chemicals
keywords: Diprobase cream; Doublebase Dayleve gel; PVP; comparison; emollients; hydration