title: After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1.
abstract: Cardiovascular and cerebrovascular ischemic disease is a large class of diseases that is harmful to human health. The primary treatment for the ischemic disease is to recover the blood perfusion and relieve the tissue hypoxia and the shortage of the nutrients in the supply of nutrients. In recent years, investigations found that IGF-1 has a protective effect on cardiovascular disease, especially in myocardial ischemia-reperfusion injury. Investigation into molecular mechanism of ischemia-reperfusion injury may offer potential targets for the development of novel diagnostic strategies. In this study we defined IGF-1 was differentially expressed in the I/R model of the Mus musculus and IGF-1 was the target gene of miR-29a and Let7f. After ischemia-reperfusion, the expression of miR-29a and Let7f increased, while the expression of IGF-1 decreased significantly in the animal model assay. Further studies have found that IGF-1 could inhibit cell apoptosis signaling pathway, thus protecting the reperfusion injury. These results provide new understanding of ischemia-reperfusion injury, with the hope of offering theoretical support for future therapeutic studies.
authors: Department of Cardiology, Xi'an Children's Hospital, No. 69, Xiju Road, Lianhu, Xi'an, Shaanxi 710003, China.
authors: Lei
authors: L
authors: Wang
authors: Department of Cardiology, Xi'an Children's Hospital, No. 69, Xiju Road, Lianhu, Xi'an, Shaanxi 710003, China.
authors: Xuehong
authors: X
authors: Niu
authors: Department of Cardiology, Xi'an Children's Hospital, No. 69, Xiju Road, Lianhu, Xi'an, Shaanxi 710003, China.
authors: Jihua
authors: J
authors: Hu
authors: Department of Cardiology, Xi'an Children's Hospital, No. 69, Xiju Road, Lianhu, Xi'an, Shaanxi 710003, China.
authors: Haijian
authors: H
authors: Xing
authors: Department of Cardiology, Xi'an Children's Hospital, No. 69, Xiju Road, Lianhu, Xi'an, Shaanxi 710003, China.
authors: Min
authors: M
authors: Sun
authors: Department of Cardiology, Xi'an Children's Hospital, No. 69, Xiju Road, Lianhu, Xi'an, Shaanxi 710003, China.
authors: Juanli
authors: J
authors: Wang
authors: Department of Cardiology, Xi'an Children's Hospital, No. 69, Xiju Road, Lianhu, Xi'an, Shaanxi 710003, China.
authors: Qiang
authors: Q
authors: Jian
authors: Department of Cardiology, Xi'an Children's Hospital, No. 69, Xiju Road, Lianhu, Xi'an, Shaanxi 710003, China.
authors: Hua
authors: H
authors: Yang
mesh_terms: D000818:Animals; D017209:Apoptosis; D005786:Gene Expression Regulation; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000473:pathology
chemical_list: C547014:MIRN29 microRNA, mouse; D035683:MicroRNAs; C519530:insulin-like growth factor-1, mouse; C542687:mirnlet7 microRNA, mouse; D007334:Insulin-Like Growth Factor I