title: Rutin Inhibits Neuroinflammation and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage, Possibly Through Suppressing the RAGE-NF-κB Inflammatory Signaling Pathway.
abstract: As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated. In this study, we investigated the potential effects of rutin on neuroinflammation and the underlying mechanism in an experimental rat model of SAH performed by endovascular perforation. Adult male SD rats were randomly divided into three groups, including sham group, SAH + vehicle group and SAH + rutin group (50 mg/kg) intraperitoneally (i.p.) administered at 30 min after SAH. After sacrificed at 24 h after SAH, all rats were examined by following tests, including neurologic scores, blood-brain barrier permeability, brain water content and neuronal cell death in cerebral cortex. The level of inflammation in brain was estimated by means of multiple molecules, including RAGE, NF-κB, and inflammation cytokines. Our results indicated that rutin could significantly downregulate the increased level of REGE, NF-κB and inflammatory cytokines in protein level. In addition, rutin could also ameliorate a series of secondary brain injuries such as brain edema, destruction of blood-brain barrier, neurological deficits and neuronal death. This study indicated that rutin administration had a neuroprotective effect in an experimental rat model of SAH, possibly through inhibiting RAGE-NF-κB mediated inflammation signaling pathway.
authors: Institute of Neurology, The Graduate Training Base of the General Hospital of Shenyang Military Area Command of PLA of Liaoning Medical College, Shenyang, 110016, Liaoning, China.
authors: Guangzhi
authors: G
authors: Hao
authors: Institute of Neurology, General Hospital of Shenyang Military Area Command, 83# Wenhua Road, Shenhe District, Shenyang, 110016, Liaoning, China.
authors: Yushu
authors: Y
authors: Dong
authors: Institute of Neurology, The Graduate Training Base of the General Hospital of Shenyang Military Area Command of PLA of Liaoning Medical College, Shenyang, 110016, Liaoning, China.
authors: Rentao
authors: R
authors: Huo
authors: Institute of Neurology, The Graduate Training Base of the General Hospital of Shenyang Military Area Command of PLA of Liaoning Medical College, Shenyang, 110016, Liaoning, China.
authors: Kai
authors: K
authors: Wen
authors: Institute of Neurology, The Graduate Training Base of the General Hospital of Shenyang Military Area Command of PLA of Liaoning Medical College, Shenyang, 110016, Liaoning, China.
authors: Yinsong
authors: Y
authors: Zhang
authors: Institute of Neurology, General Hospital of Shenyang Military Area Command, 83# Wenhua Road, Shenhe District, Shenyang, 110016, Liaoning, China. liangguobiao1965@163.com.
authors: Guobiao
authors: G
authors: Liang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D018836:Inflammation Mediators; D008297:Male; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000066829:Neuroprotection / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000067759:Receptor for Advanced Glycation End Products / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012431:Rutin / Q000494:pharmacology* / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013345:Subarachnoid Hemorrhage / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control
chemical_list: C000593874:Ager protein, rat; D018836:Inflammation Mediators; D016328:NF-kappa B; D000067759:Receptor for Advanced Glycation End Products; D012431:Rutin
keywords: NF-κB; Neuroinflammation; RAGE; Rutin; Subarachnoid hemorrhage