title: Bringing IDH into the Fold.
abstract: Glioma-associated mutations in IDH1 or IDH2 lead to aberrant DNA methylation. A recent paper shows that loss of methylation-sensitive CTCF binding in IDH mutant cells leads to disruption of enhancer boundary function, which results in aberrant activation of PDGFRA expression via an enhancer associated with an adjacent gene.
authors: Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada; Division of Neurosurgery, University Health Network, Toronto, ON M5T 2S8, Canada. Electronic address: gelareh.zadeh@uhn.ca.
authors: Gelareh
authors: G
authors: Zadeh
authors: Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada; Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON M5T 2S8, Canada.
authors: Kenneth
authors: K
authors: Aldape
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000201:enzymology* / Q000235:genetics*; D006801:Humans; D038101:Insulator Elements / Q000235:genetics*; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics*
chemical_list: D007521:Isocitrate Dehydrogenase