title: Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke.
abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a neuroprotective transcription factor that has recently attracted increased attention. Stroke, a common and serious neurological disease, is currently a leading cause of death in the USA so far. It is therefore of vital importance to explore how Nrf2 behaves in stroke. In this review, we first introduce the structural features of Nrf2 and Kelch-like ECH-associated protein 1 (Keap1) and briefly depict the activation, inactivation, and regulation processes of the Nrf2 pathway. Next, we discuss the physiopathological mechanisms, upstream modulators, and downstream targets of the Nrf2 pathway. Following this background, we expand our discussion to the roles of Nrf2 in ischemic and hemorrhagic stroke and provide several potential future directions. The information presented here may be useful in the design of future experimental research and increase the likelihood of using Nrf2 as a therapeutic target for stroke in the future.
authors: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East, Zhengzhou, 450052, China.|Department of Aerospace Medicine, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, China.
authors: Shuai
authors: S
authors: Jiang
authors: Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an, 710032, China.
authors: Chao
authors: C
authors: Deng
authors: Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, China.
authors: Jianjun
authors: J
authors: Lv
authors: Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Xi'an, 710038, China.
authors: Chongxi
authors: C
authors: Fan
authors: Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, China.
authors: Wei
authors: W
authors: Hu
authors: Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, China.
authors: Shouyin
authors: S
authors: Di
authors: Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, China.
authors: Xiaolong
authors: X
authors: Yan
authors: Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, China.
authors: Zhiqiang
authors: Z
authors: Ma
authors: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East, Zhengzhou, 450052, China. zhenxingliang888@163.com.
authors: Zhenxing
authors: Z
authors: Liang
authors: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East, Zhengzhou, 450052, China. yang200214yy@163.com.|Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, China. yang200214yy@163.com.
authors: Yang
authors: Y
authors: Yang
mesh_terms: D000818:Animals; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D000066829:Neuroprotection / Q000502:physiology*; D060066:Protein Interaction Maps / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D020521:Stroke / Q000378:metabolism* / Q000517:prevention & control*
chemical_list: D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human
keywords: Hemorrhage; Ischemia; Nuclear factor erythroid 2-related factor 2; Oxidative stress