title: Skeletal Implications of Chronic Obstructive Pulmonary Disease.
abstract: Chronic obstructive pulmonary disease (COPD) is associated with numerous comorbidities, among which osteoporosis is of high significance. Low bone mass and the occurrence of fragility fractures is a common finding in patients with COPD. Typical risk factors related directly or indirectly to these skeletal complications include systemic inflammation, tobacco smoking, vitamin D deficiency, and treatment with oral or inhaled corticosteroids. In particular, treatment with glucocorticoids appears to be a strong contributor to bone changes in COPD, but does not fully account for all skeletal complications. Additional to the effects of COPD on bone mass, there is evidence for COPD-related changes in bone microstructure and material properties. This review summarizes the clinical outcomes of low bone mass and increased fracture risk, and reports on recent observations in bone tissue and material in COPD patients.
authors: Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria. barbara.misof@osteologie.at.
authors: Barbara M
authors: BM
authors: Misof
authors: Endocrine Division (SEMPR), Department of Internal Medicine, Clinical Hospital of the Federal University of Parana, Curitiba, PR, Brazil.|Laboratory P.R.O-Bone Histomorphometry Division, Fundação Pro-Renal, Curitiba, PR, Brazil.
authors: Carolina A
authors: CA
authors: Moreira
authors: Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria.
authors: Klaus
authors: K
authors: Klaushofer
authors: Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria.
authors: Paul
authors: P
authors: Roschger
mesh_terms: D001842:Bone and Bones / Q000473:pathology; D050723:Fractures, Bone / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D006801:Humans; D010024:Osteoporosis / Q000453:epidemiology* / Q000209:etiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000188:drug therapy
keywords: Bone biopsy; Bone matrix mineralization; Bone mineral density; Chronic obstructive pulmonary disease; Fracture risk; Histomorphometry