title: Bilateral Aleukemic Myeloid Sarcoma of the Eyelids With Indolent Course.
abstract: Leukemic infiltrates may be seen in the skin in the absence of detectable bone marrow involvement. Leukemia cutis may exceptionally occupy the eyelids. An unusual case of a 58-year-old man presenting bilateral erythematous eyelid lesions, proven to be aleukemic leukemia cutis, is reported. Biopsy was conducted and hematoxylin/eosin stained sections were histologically evaluated. Immunohistochemistry was also performed.Light microscopy revealed cutaneous infiltration by a neoplastic population consisting of medium-sized cells. These cells infiltrated the overlying epidermis leading to focal microulcerations. The morphological and immunohistochemical characteristics of the neoplastic population were compatible with myeloid leukemia cutis. The bone marrow biopsy was normocellular for the patient's age. Although chemotherapy was advised, the patient refused any treatment. He remains free of leukemia or evolution of eyelid lesions approximately 1 year after diagnosis. Leukemia cutis of the eyelids is a rare manifestation of acute leukemia and may remain aleukemic in adults for an indefinite period of time.
authors: *Department of Pathology, Faculty of Medicine, Aristotle University, Thessaloniki, Greece; †Department of Dermatology, Cutaneous Lymphoma Clinic, 'Papageorgiou' General Hospital, Thessaloniki, Greece; and ‡Department of Dermatology, Faculty of Medicine, Aristotle University, Thessaloniki, Greece.
authors: Alexandros
authors: A
authors: Iliadis
authors: Triantafyllia
authors: T
authors: Koletsa
authors: Elisavet
authors: E
authors: Georgiou
authors: Aikaterini
authors: A
authors: Patsatsi
authors: Dimitrios
authors: D
authors: Sotiriadis
authors: Ioannis
authors: I
authors: Kostopoulos
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005142:Eyelid Neoplasms / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D023981:Sarcoma, Myeloid / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor