title: Prostatic adenocarcinoma presenting with metastases to the testis and epididymis: A case report.
abstract: Few cases of testicular metastases from prostate carcinoma have been reported, and asymptomatic metastases of prostate carcinoma to both the testis and epididymis are extremely rare. The current study presents the case of a 69-year-old male with testicular and epididymal metastases from prostate carcinoma. The patient was admitted to The First Hospital of Shijiazhuang with a 2-year history of lower urinary tract symptoms. Digital rectal examination revealed an enlarged multinodular prostate, and the serum prostate-specific antigen (PSA) level was >100 ng/ml. Magnetic resonance imaging showed prostate carcinoma with seminal vesicle involvement. A prostate biopsy showed prostate gland adenocarcinoma. The Gleason score was 3+3. The immunohistochemistry results were as follows: Prostatic acid phosphatase (+++), PSA (+++), P504s (+++), p63 (-) and cytokeratin 34βE12 (-), with a Ki-67 of ~5%. The patient was treated with a bilateral orchiectomy. The testicular pathology showed that the right testis and epididymis were invaded with metastatic adenocarcinoma. The left testis and epididymis were normal. The patient was treated with conventional flutamide endocrine therapy. At present the patient remains in a stable condition after 24 months of follow-up.
authors: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China.
authors: Jin
authors: J
authors: Zhang
authors: Department of Surgery, The Affiliated Hospital of Hebei Science and Technology University, Shijiazhuang, Hebei, P.R. China.
authors: Mei
authors: M
authors: Dong
authors: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China.
authors: Xiaolei
authors: X
authors: Hu
authors: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China.
authors: Lin
authors: L
authors: Liu
authors: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China.
authors: Shen
authors: S
authors: Li
authors: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China.
authors: Chao
authors: C
authors: Li
authors: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China.
authors: Lijun
authors: L
authors: Yang
authors: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China.
authors: Yongqiang
authors: Y
authors: Xiao
authors: Department of Urology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China.
authors: Shujian
authors: S
authors: Pang
authors: Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
authors: Chuan
authors: C
authors: Wang
keywords: epididymis; metastasis; prostatic adenocarcinoma; testis