title: Gold(I)-Catalyzed Angle Strain Controlled Strategy to Furopyran Derivatives from Propargyl Vinyl Ethers: Insight into the Regioselectivity of Cycloisomerization.
abstract: A unique strategy for the regiospecific synthesis of bicyclic furopyran derivatives has been developed via a gold(I)-catalyzed propargyl-Claisen rearrangement/6-endo-trig cyclization of propargyl vinyl ethers. The introduction of angle strain into the substrates significantly altered the reaction's regioselectivity. Insight into the regioselectivity of the cycloisomerization was obtained with density functional theory calculations.
authors: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016, P. R. China.|Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
authors: Shengfei
authors: S
authors: Jin
authors: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016, P. R. China.|Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
authors: Chongguo
authors: C
authors: Jiang
authors: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016, P. R. China.|Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
authors: Xiaoshi
authors: X
authors: Peng
authors: School of Chemistry and Chemical Engineering, Chongqing University , Chongqing 400030, P. R. China.
authors: Chunhui
authors: C
authors: Shan
authors: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016, P. R. China.|Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
authors: Shanshan
authors: S
authors: Cui
authors: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016, P. R. China.|Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
authors: Yuanyuan
authors: Y
authors: Niu
authors: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016, P. R. China.|Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
authors: Yang
authors: Y
authors: Liu
authors: School of Chemistry and Chemical Engineering, Chongqing University , Chongqing 400030, P. R. China.
authors: Yu
authors: Y
authors: Lan
authors: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016, P. R. China.|Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
authors: Yongxiang
authors: Y
authors: Liu
authors: Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016, P. R. China.|Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
authors: Maosheng
authors: M
authors: Cheng