title: [Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice].
abstract: The comparative study of the therapeutic efficacy of Triazavirin against experimental Forest-Spring encephalitis on albino mice vs. the active drug Ribavirin® showed that in high doses (200-400 mg/kg) Triazavirin moderately protected the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically (p ≤ 0.05) valid decrease of the virus accumulation in the target organ (the brain) were observed.
authors: S Ya
authors: SY
authors: Loginova
authors: S V
authors: SV
authors: Borisevich
authors: V L
authors: VL
authors: Rusinov
authors: E N
authors: EN
authors: Ulomsky
authors: V N
authors: VN
authors: Charushin
authors: O N
authors: ON
authors: Chupakhin
authors: P V
authors: PV
authors: Sorokin
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000821:virology; D004669:Encephalitis Viruses, Tick-Borne / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000821:virology; D051379:Mice; D012254:Ribavirin / Q000494:pharmacology; D016019:Survival Analysis; D016896:Treatment Outcome; D014227:Triazines / Q000494:pharmacology*; D014230:Triazoles; D019562:Viral Load / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D001393:Azoles; D014227:Triazines; D014230:Triazoles; D012254:Ribavirin; C539416:riamilovir