title: Assembly mechanism of Trypanosoma brucei BILBO1 at the flagellar pocket collar.
abstract: The flagellar pocket is a bulb-like invagination of the plasma membrane that encloses the base of the single flagellum in trypanosomes. It is the site of all endo- and exocytic activity in the parasite and has thus been proposed to be a therapeutic target. At the neck of the flagellar pocket is an electron-dense cytoskeletal structure named the flagellar pocket collar. The protein BILBO1 was the first characterized and remains the only known component of the flagellar pocket collar, with essential functions in the biogenesis of both the flagellar pocket and flagellar pocket collar. We recently reported that the filamentous assembly of Trypanosoma brucei BILBO1 (TbBILBO1) is mediated by its central coiled coil domain and C-terminal leucine zipper. Here, we discuss how TbBILBO1 might assemble at the flagellar pocket collar in T. brucei.
authors: Max F. Perutz Laboratories; University of Vienna and Medical University of Vienna ; Vienna, Austria.
authors: Keni
authors: K
authors: Vidilaseris
authors: Max F. Perutz Laboratories; University of Vienna and Medical University of Vienna ; Vienna, Austria.
authors: Johannes
authors: J
authors: Lesigang
authors: Max F. Perutz Laboratories; University of Vienna and Medical University of Vienna ; Vienna, Austria.
authors: Brooke
authors: B
authors: Morriswood
authors: Max F. Perutz Laboratories; University of Vienna and Medical University of Vienna ; Vienna, Austria.
authors: Gang
authors: G
authors: Dong
keywords: BILBO1; Trypanosoma brucei; cytoskeleton; flagellar pocket; flagellar pocket collar; parasite; protein assembly