title: Humoral cross reactivity between α-synuclein and herpes simplex-1 epitope in Parkinson's disease, a triggering role in the disease?
abstract: Environmental factors are implicated in the development of Parkinson's disease (PD). We have investigated on the role of molecular mimicry between HSV1 and α-synuclein that could foster the progression of PD. The antibody response against homologous peptides in PD patients and healthy controls was evaluated, showing that these antibodies are highly prevalent among PD patients to healthy controls. The competitive assay demonstrated cross-reactivity between HSV1 and human α-synuclein peptides. The results may suggest the hypothesis of the involvement of HSV1 in stimulating the immune cells against the neurons of the substantia nigra as a consequence of the cross reactivity.
authors: Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, Italy.
authors: Elisa
authors: E
authors: Caggiu
authors: Dipartimento di Medicina Clinica e Sperimentale, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.
authors: Kai
authors: K
authors: Paulus
authors: Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, Italy; Dipartimento di Medicina Clinica e Sperimentale, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.
authors: Giannina
authors: G
authors: Arru
authors: Dipartimento di Medicina Clinica e Sperimentale, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.
authors: Rosanna
authors: R
authors: Piredda
authors: Dipartimento di Medicina Clinica e Sperimentale, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.
authors: Gian Pietro
authors: GP
authors: Sechi
authors: Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, Italy. Electronic address: sechila@uniss.it.
authors: Leonardo A
authors: LA
authors: Sechi
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017405:Herpes Simplex Virus Protein Vmw65 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018716:Molecular Mimicry; D010300:Parkinson Disease / Q000150:complications*; D010455:Peptides / Q000378:metabolism; D012372:ROC Curve; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D017405:Herpes Simplex Virus Protein Vmw65; D010455:Peptides; C497604:SNCA protein, human; D051844:alpha-Synuclein
keywords: Autoimmunity; Cross-reactivity; HSV1; Parkinson's disease; α-Synuclein