title: C3 and 2D C3 Marfey's Methods for Amino Acid Analysis in Natural Products.
abstract: We validate the improved resolution and sensitivity of the C3 Marfey's method, including an ability to resolve all Ile isomers, against an array of amino acids commonly encountered in natural products and by comparison to an existing Marfey's method. We also describe an innovative 2D C3 Marfey's method as an analytical approach for determining the regiochemistry of enantiomeric amino acid residues in natural products. The C3 and 2D C3 Marfey's methods represent valuable tools for probing and defining the stereocomplexity of hydrolytically accessible amino acid residues in natural products.
authors: Institute for Molecular Bioscience, The University of Queensland , St. Lucia, Queensland 4072, Australia.
authors: Soumini
authors: S
authors: Vijayasarathy
authors: Institute for Molecular Bioscience, The University of Queensland , St. Lucia, Queensland 4072, Australia.
authors: Pritesh
authors: P
authors: Prasad
authors: Institute for Molecular Bioscience, The University of Queensland , St. Lucia, Queensland 4072, Australia.
authors: Leith J
authors: LJ
authors: Fremlin
authors: Institute for Molecular Bioscience, The University of Queensland , St. Lucia, Queensland 4072, Australia.
authors: Ranjala
authors: R
authors: Ratnayake
authors: Institute for Molecular Bioscience, The University of Queensland , St. Lucia, Queensland 4072, Australia.
authors: Angela A
authors: AA
authors: Salim
authors: Institute for Molecular Bioscience, The University of Queensland , St. Lucia, Queensland 4072, Australia.
authors: Zeinab
authors: Z
authors: Khalil
authors: Institute for Molecular Bioscience, The University of Queensland , St. Lucia, Queensland 4072, Australia.
authors: Robert J
authors: RJ
authors: Capon
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives / Q000737:chemistry; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis* / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry*; D004136:Dinitrobenzenes; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D001688:Biological Products; D004136:Dinitrobenzenes; C047134:Marfey's reagent; D000409:Alanine