title: Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature.
abstract: Photothermal therapy (PTT) at present, following the temperature definition for conventional thermal therapy, usually keeps the temperature of lesions at 42-45 °C or even higher. Such high temperature kills cancer cells but also increases the damage of normal tissues near lesions through heat conduction and thus brings about more side effects and inhibits therapeutic accuracy. Here we use temperature-feedback upconversion nanoparticle combined with photothermal material for real-time monitoring of microscopic temperature in PTT. We observe that microscopic temperature of photothermal material upon illumination is high enough to kill cancer cells when the temperature of lesions is still low enough to prevent damage to normal tissue. On the basis of the above phenomenon, we further realize high spatial resolution photothermal ablation of labelled tumour with minimal damage to normal tissues in vivo. Our work points to a method for investigating photothermal properties at nanoscale, and for the development of new generation of PTT strategy.
authors: Institutes of Biomedical Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Xingjun
authors: X
authors: Zhu
authors: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Wei
authors: W
authors: Feng
authors: Department of Physics, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Jian
authors: J
authors: Chang
authors: Department of Physics, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Yan-Wen
authors: YW
authors: Tan
authors: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Jiachang
authors: J
authors: Li
authors: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Min
authors: M
authors: Chen
authors: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Yun
authors: Y
authors: Sun
authors: Institutes of Biomedical Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China.|Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, China.|Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Fuyou
authors: F
authors: Li
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D005246:Feedback; D006367:HeLa Cells; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D032446:Myoblasts; D053761:Nanocomposites; D053758:Nanoparticles; D036103:Nanotechnology; D009369:Neoplasms / Q000628:therapy*; D010789:Phototherapy; D013696:Temperature