title: Genetics of Glucose regulation in Gestation and Growth (Gen3G): a prospective prebirth cohort of mother-child pairs in Sherbrooke, Canada.
abstract: OBJECTIVE
  We initiated the Genetics of Glucose regulation in Gestation and Growth (Gen3G) prospective cohort to increase our understanding of biological, environmental and genetic determinants of glucose regulation during pregnancy and their impact on fetal development.
  
  
  METHODS
  Between January 2010 and June 2013, we invited pregnant women aged ≥ 18 years old who visited the blood sampling in pregnancy clinic in Sherbrooke for their first trimester clinical blood samples: 1034 women accepted to participate in our cohort study.
  
  
  RESULTS
  At first and second trimester, we collected demographics and lifestyle questionnaires, anthropometry measures (including fat and lean mass estimated using bioimpedance), blood pressure, and blood samples. At second trimester, women completed a full 75 g oral glucose tolerance test and we collected additional blood samples. At delivery, we collected cord blood and placenta samples; obstetrical and neonatal clinical data were abstracted from electronic medical records. We also collected buffy coats and extracted DNA from maternal and/or offspring samples (placenta and blood cells) to pursue genetic and epigenetic hypotheses. So far, we have found that low adiponectin and low vitamin D maternal levels in first trimester predict higher risk of developing gestational diabetes.
  We are now in the phase of prospective follow-up of mothers and offspring 3 and 5 years postdelivery to investigate the consequences of maternal dysglycaemia during pregnancy on offspring adiposity and metabolic profile.
  
  
  BACKGROUND
  NCT01623934.
authors: Faculty of Medicine and Life Sciences, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Laetitia
authors: L
authors: Guillemette
authors: Faculty of Sciences, Department of Mathematics, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Catherine
authors: C
authors: Allard
authors: Faculty of Medicine and Life Sciences, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Marilyn
authors: M
authors: Lacroix
authors: Faculty of Medicine and Life Sciences, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Julie
authors: J
authors: Patenaude
authors: Faculty of Medicine and Life Sciences, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Marie-Claude
authors: MC
authors: Battista
authors: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Myriam
authors: M
authors: Doyon
authors: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Julie
authors: J
authors: Moreau
authors: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Julie
authors: J
authors: Ménard
authors: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada Faculty of Medicine and Life Sciences, Department of Biochemistry, Université de Sherbrooke, Sherbrooke, Quebec, Canada ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, Quebec, Canada.
authors: Luigi
authors: L
authors: Bouchard
authors: Faculty of Medicine and Life Sciences, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Jean-Luc
authors: JL
authors: Ardilouze
authors: Faculty of Medicine and Life Sciences, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Patrice
authors: P
authors: Perron
authors: Faculty of Medicine and Life Sciences, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts, USA Massachusetts General Hospital, Boston, Massachusetts, USA.
authors: Marie-France
authors: MF
authors: Hivert
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition; D015992:Body Mass Index; D002170:Canada / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000453:epidemiology* / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000235:genetics*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000453:epidemiology* / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000378:metabolism; D011446:Prospective Studies; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014807:Vitamin D / Q000031:analogs & derivatives / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000453:epidemiology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D014409:Tumor Necrosis Factor-alpha; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: EPIDEMIOLOGY; GENETICS