title: [SYNERGISM OF PRECONCEPTIVE RADIATION EXPOSURE AND PARENTS' ONCO-PATHOLOGY IN THE RISE OF CARCINOGENIC RISK IN THE OFFSPRINGS OF PROFESSIONAL EMPLOYEES].
abstract: The problem of carcinogenic risk in offsprings of individuals exposed to radiation is challenging and insufficiently studied. In that there are no evaluations of the interaction between radiation and non-radiation factors. The aim of the study was the analysis of interaction of preconceptive radiation exposure and parents' onco-pathology in cancer mortality in offsprings (F1) of workers (fathers) of the Mayak Production Association exposed to a wide range of doses of radiation over a year prior conception. The number of offspring is 8191 individuals (4180 men and 4011 women). The analysis was performed with the use of fourfold table and eightfold tables. The interaction offactors was estimated on the base of the additive and multiplicative models. The studied factors were independent. The odds ratio (OR) of cancer mortality in the offspring with parents' oncopathology (1.43) was insignificant. OR of cancer mortality in preconceptive radiation exposure in a dose over 110 mGy and without parents' onco-pathology was 2.61 (1.52-4.49), and in their combination--3.86 (1.93-7.71). Index of synergism of preconceptive radiation exposure and parents' onco-patholog in the rise of carcinogenic risk in the offspring was 1.34 and the character of their interaction was multiplicative. Thus, for the first time there was established the interaction between radiation and non-radiation factors in the synergism sort in the increase of carcinogenic risk in the offspring of people exposed to radiation.
authors: V I
authors: VI
authors: Telnov
authors: N R
authors: NR
authors: Kabirova
authors: P V
authors: PV
authors: Okatenko
mesh_terms: D000328:Adult; D063646:Carcinogenesis / Q000528:radiation effects; D002648:Child; D016241:Child of Impaired Parents / Q000706:statistics & numerical data*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects / Q000706:statistics & numerical data; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000145:classification / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis / Q000706:statistics & numerical data; D018812:Paternal Exposure / Q000009:adverse effects / Q000706:statistics & numerical data; D047489:Preconception Injuries / Q000453:epidemiology / Q000209:etiology; D018570:Risk Assessment / Q000379:methods; D012426:Russia / Q000453:epidemiology; D016019:Survival Analysis