title: Percutaneous Thermal Ablation of Breast Cancer Metastases in Oligometastatic Patients.
abstract: OBJECTIVE
  To evaluate prognostic factors associated with local control and disease-free-survival (DFS) of oligometastatic breast cancer patients treated by percutaneous thermal ablation (PTA).
  
  
  METHODS
  Seventy-nine consecutive patients (54.5 ± 11.2 years old) with 114 breast cancer metastases (28.9 ± 16.1 mm in diameter), involving the lungs, the liver, and/or the bone, were treated using PTA with a curative intent. The goal was to achieve a complete remission in association with systemic chemotherapy and hormonal therapy. We retrospectively evaluated the prognostic factors associated with 1- and 2-year local control and the 1- and 2-year DFS rates.
  
  
  RESULTS
  The 1- and 2-year local control rates were 83.0 and 76.1 %, respectively. Tumor burden was associated with a poorer outcome for local control after PTA (HR 1.027 by additional millimeter, p = 0.026; >4 cm HR 3.90). The 1- and 2-year DFS rates were 54.2 and 30.4 %, respectively. In multivariate analysis, triple-negative histological subtype and increased size of treated metastases were associated with a poorer DFS (HR 2.22; 95 % CI [1.13-4.36]; p = 0.02 and HR 2.43; 95 % CI [1.22-4.82]; p = 0.011, respectively).
  
  
  CONCLUSIONS
  PTA is effective for local control of breast cancer oligometastases. Tumor burden >4 cm and triple-negative histological subtype are associated with a poorer outcome.
authors: Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France. matthias_barral@yahoo.fr.
authors: M
authors: M
authors: Barral
authors: Biostatistics and Epidemiology Unit, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France.
authors: A
authors: A
authors: Auperin
authors: Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France.
authors: A
authors: A
authors: Hakime
authors: Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France.
authors: V
authors: V
authors: Cartier
authors: Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France.
authors: V
authors: V
authors: Tacher
authors: Radiotherapy, Centre Clinique de la Porte de Saint-Cloud, 37 avenue Victor Hugo, 92100, Boulogne Billancourt, France.
authors: Yves
authors: Y
authors: Otmezguine
authors: Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France.
authors: L
authors: L
authors: Tselikas
authors: Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France.
authors: T
authors: T
authors: de Baere
authors: Interventional Radiology Department, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France.
authors: F
authors: F
authors: Deschamps
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D004564:Electrocoagulation / Q000379:methods*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Breast neoplasms; Cryotherapy; Metastases; Microwave ablation; Radiofrequency ablation