title: Body Composition Changes in Adult Females after Lifestyle Intervention Are Influenced by the NYD-SP18 Variant.
abstract: OBJECTIVE
  The study focuses on the analysis of the possible relationship between a common NYD-SP18 (rs6971091, G>A) gene polymorphism and weight loss after lifestyle intervention (combined dietary intake and physical activity) in overweight/obese females.
  
  
  METHODS
  We genotyped 139 unrelated non-diabetic Czech females (49.5 ± 13.3 years, average BMI at baseline 32.2 ± 4.6 kg/m². Biochemical and anthropometrical measurements were performed before and after ten weeks of lifestyle intervention.
  
  
  CONCLUSIONS
  Overweight/obese female carriers of the NYD-SP18 rs6971091 GG genotype exhibited a more beneficial response to the intensive lifestyle intervention than others.
authors: Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.|Faculty of Public Health and Social Studies, South Bohemia University, České Budějovice, Czech Republic.
authors: Pavel
authors: P
authors: Suchánek
authors: Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors: Věra
authors: V
authors: Lánská
authors: Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors: Jaroslav Alois
authors: JA
authors: Hubáček
mesh_terms: D000328:Adult; D000368:Aged; D001823:Body Composition / Q000235:genetics*; D018153:Czech Republic; D004038:Diet, Reducing; D015444:Exercise; D005260:Female; D020690:GTPase-Activating Proteins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D009765:Obesity / Q000235:genetics* / Q000517:prevention & control; D050177:Overweight / Q000235:genetics* / Q000517:prevention & control; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015431:Weight Loss / Q000235:genetics*
chemical_list: C570078:FAM13A protein, human; D020690:GTPase-Activating Proteins
keywords: NYD-SP18; females; intervention; obesity; polymorphism