title: A subchronic feeding study of dicamba-tolerant soybean with the dmo gene in Sprague-Dawley rats.
abstract: The dicamba-tolerant soybean MON87708 expresses the dicamba mono-oxygenase (DMO) enzyme that is encoded by the dmo gene. In order to evaluate the safety of this soybean, a 90-day subchronic feeding toxicity study (13 weeks) was conducted on Sprague-Dawley rats. A total of 140 rats were divided into 7 groups (10/sex/group), including a standard commercial diet control group. The genetically modified (GM) soybean MON87708 and the near isogenic non-GM soybean A3525 were respectively processed to unhulled, full-fat, and heat-treated powder, then mixed into the diet at levels of 7.5%, 15%, and 30% (wt/wt) with the main nutrients of the various diets balanced and then fed to 6 groups. The remaining group of rats fed with a commercial rat diet served as blank control. Some isolated parameters indicated statistically significant differences in body weight, feed consumption/utilization, hematology, serum biochemistry, and relative organ weights. These differences were not consistent across gender or test-diet dose, which were attributed to incidental and biological variability. In conclusion, the results demonstrated that the transgenic soybean MON87708 containing DMO was as safe as non-transgenic isogenic counterpart with historical safe use.
authors: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
authors: Xiaoyun
authors: X
authors: Wang
authors: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China; The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, China.
authors: Xiaoyun
authors: X
authors: He
authors: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China; The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, China.
authors: Shiyin
authors: S
authors: Zou
authors: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China; The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, China.
authors: Wentao
authors: W
authors: Xu
authors: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
authors: Xin
authors: X
authors: Jia
authors: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
authors: Bo
authors: B
authors: Zhao
authors: Department of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA.
authors: Changhui
authors: C
authors: Zhao
authors: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China; The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, China.
authors: Kunlun
authors: K
authors: Huang
authors: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China; The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, China. Electronic address: liangzhihong@cau.edu.cn.
authors: Zhihong
authors: Z
authors: Liang
mesh_terms: D000821:Animal Feed / Q000633:toxicity; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003996:Dicamba / Q000378:metabolism / Q000633:toxicity*; D004351:Drug Resistance / Q000235:genetics*; D004435:Eating; D005260:Female; D059022:Food Safety / Q000379:methods*; D030841:Food, Genetically Modified / Q000009:adverse effects*; D018506:Gene Expression Regulation, Plant; D005838:Genotype; D006540:Herbicides / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D006899:Mixed Function Oxygenases / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D030821:Plants, Genetically Modified / Q000235:genetics / Q000378:metabolism / Q000633:toxicity*; D017207:Rats, Sprague-Dawley; D018570:Risk Assessment; D013025:Glycine max / Q000235:genetics / Q000378:metabolism / Q000633:toxicity*; D013997:Time Factors; D059550:Toxicity Tests, Subchronic / Q000379:methods*; D015430:Weight Gain
chemical_list: D015415:Biomarkers; D006540:Herbicides; D006899:Mixed Function Oxygenases; D003996:Dicamba
keywords: Food safety; Subchronic feeding study; Trangenic soybean