title: Skin tumor immunity: Site does matter for antigen presentation by DCs.
abstract: The immune system has the ability to specifically identify and eliminate tumors, but the underlying mechanisms responsible for this phenomenon are not fully understood. A study published in this issue of the European Journal of Immunology now provides new insights into this important problem. Joncker et al. [Eur. J. Immunol. 2016. 46: 609-618] show that the timely mobilization of tumor antigen-bearing dendritic cells (DCs) from the periphery to the lymph nodes is critical for effective antitumor T-cell immunity, and that DCs present tumor antigens much more efficiently when encountered in the skin rather than in the subcutaneous tissues.
authors: Telethon Kids Institute, University of Western Australia, Subiaco, Australia.
authors: Jason
authors: J
authors: Waithman
authors: Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
authors: Thomas
authors: T
authors: Gebhardt
authors: Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
authors: Sammy
authors: S
authors: Bedoui
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology*; D009369:Neoplasms / Q000276:immunology*
keywords: Antigen presentation/processing; Dendritic cells; T cells; Tumor immunology