title: Salmonella Vaccination in Pigs: A Review.
abstract: The control of Salmonella enterica in pig production is necessary for both public and animal health. The persistent and frequently asymptomatic nature of porcine Salmonella infection and the organism's abilities to colonize other animal species and to survive in the environment mean that effective control generally requires multiple measures. Vaccination is one such measure, and the present review considers its role and its future, drawing on studies in pigs from the 1950s to the present day. Once established in the body as an intracellular infectious agent, Salmonella can evade humoral immunity, which goes some way to explaining the often disappointing performance of inactivated Salmonella vaccines. More recent approaches, using mucosal presentation of antigens, live vaccines and adjuvants to enhance cell-mediated immunity, have met with more success. Vaccination strategies that involve stimulating both passive immunity from the dam plus active immunity in offspring appear to be most efficacious, although either approach alone can yield significant control of Salmonella. Problems that remain include relatively poor control of Salmonella serovars that are dissimilar to the vaccine antigen mix, and difficulties in measuring and predicting the performance of candidate vaccines in ways that are highly relevant to their likely use in commercial production.
authors: Department of Bacteriology and Food Safety, Animal and Plant Health Agency Weybridge, Addlestone, Surrey, UK.
authors: A D
authors: 0000-0002-8657-3007
authors: AD
authors: Wales
authors: Department of Bacteriology and Food Safety, Animal and Plant Health Agency Weybridge, Addlestone, Surrey, UK.
authors: R H
authors: RH
authors: Davies
mesh_terms: D000818:Animals; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D022562:Salmonella Vaccines / Q000276:immunology*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D015047:Zoonoses
chemical_list: D022562:Salmonella Vaccines
keywords: Salmonella spp; foodborne pathogens; preventive medicine; swine; zoonoses