title: Catalyst and solvent-free alkylation of quinoline N-oxides with olefins: A direct access to quinoline-substituted α-hydroxy carboxylic derivatives.
abstract: A catalyst/solvent-free, one-pot and operationally simple method for the synthesis of quinoline-substituted α-hydroxy carboxylic derivatives by the hydroxyheteroarylation of olefins with quinoline N-oxides is reported. The reaction features a high atom-economy, mild and reagent/solvent-free conditions, broad substrate scope and good selectivity with high yields. A preliminary mechanistic study to shed light into the reaction pathway was also carried out.
authors: Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh 176 061, India. upendra@ihbt.res.in and Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, Himachal Pradesh 176 061, India.
authors: Rakesh
authors: R
authors: Kumar
authors: Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh 176 061, India. upendra@ihbt.res.in and Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, Himachal Pradesh 176 061, India.
authors: Inder
authors: I
authors: Kumar
authors: Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh 176 061, India. upendra@ihbt.res.in and Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, Himachal Pradesh 176 061, India.
authors: Ritika
authors: R
authors: Sharma
authors: Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh 176 061, India. upendra@ihbt.res.in and Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, Himachal Pradesh 176 061, India.
authors: Upendra
authors: U
authors: Sharma