title: Neurodevelopmental Follow Up After Therapeutic Hypothermia for Perinatal Asphyxia.
abstract: BACKGROUND
  Neuroprotective benefit of therapeutic hypothermia in term newborns with hypoxic-ischemic encephalopathy (HIE) was assessed by analyzing survival and neurodevelopmental outcome of neonates subjected to this procedure.
  
  
  METHODS
  Newborns with gestational age > 36 weeks and < 6 hours of age with moderate to severe asphyxial encephalopathy underwent cooling protocol at a temperature of 33.5 °C for 72 hours and rewarming period of 6 hours. Outcome measures assessed were death and neurodevelopmental characteristics, which were compared at the different age using ASQ-3. Twenty-five children were assessed at age 3-6, 12-18 and 24-36 months. Median gestational age was 40 weeks, birth weight 3470 g, Apgar score 2/4 and pH on admission to the hospital 7.02. Four (16%) children died.
  
  
  RESULTS
  At the first assessment developmental categories of communication were normal in 78.9%, problem solving in 63.2%, personal-social in 68.4%, gross motor in 68.4%, and fine motor in 42.1% with a high need of retesting in this area. Second assessment was done in 17 patients: developmental categories of communication normal in 58.8%, problem solving in 70.6%, personal-social in 64.7%, gross motor in 64.7%, and fine motor in 35.3%. Third evaluation was done in 14 patients: developmental categories of communication were normal in 64.3%, problem solving in 71.4%, personal-social in 57.1%, gross motor in 64.3%, and fine motor in 42.9%.
  
  
  CONCLUSIONS
  There was no correlation between baseline parameters and outcome. Results of the study are showing that therapeutic hypothermia in term newborns can provide better survival and less neurologic sequels in HIE patients.
authors: Pediatric hospital, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors: Smail
authors: S
authors: Zubcevic
authors: Pediatric hospital, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors: Suada
authors: S
authors: Heljic
authors: Pediatric hospital, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors: Feriha
authors: F
authors: Catibusic
authors: Pediatric hospital, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors: Sajra
authors: S
authors: Uzicanin
authors: Pediatric hospital, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors: Mirna
authors: M
authors: Sadikovic
authors: Pediatric hospital, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors: Belma
authors: B
authors: Krdzalic
mesh_terms: D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000628:therapy*; D002675:Child, Preschool; D005260:Female; D005865:Gestational Age; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D065886:Neurodevelopmental Disorders / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D011795:Surveys and Questionnaires
keywords: neurodevelopmental outcome; perinatal asphyxia; therapeutic hypothermia