title: Interstitial stromal progenitors during kidney development: here, there and everywhere.
abstract: In recent years, the renal interstitium has been identified as the site of multiple cell types, giving rise to multiple contiguous cellular networks with multiple fundamental structural and functional roles. Few studies have been carried out on the morphological and functional properties of the stromal/interstitial renal cells during the intrauterine life. This work was aimed at reviewing the peculiar features of renal interstitial stem/progenitor cells involved in kidney development. The origin of the renal interstitial progenitor cells remains unknown. During kidney development, besides the Six2 + cells of the cap mesenchyme, a self-renewing progenitor population, characterized by the expression of Foxd1, represents the first actor of the non-nephrogenic lineage. Foxd1 + interstitial progenitors originate the cortical and the renal medullary interstitial progenitors. Here, the most important stromal/interstitial compartments present in the developing human kidney will be analyzed: capsular stromal cells, cortical interstitial cells, medullary interstitial cells, the interstitium inside the renal stem cell niche, Hilar interstitial cells and Ureteric interstitial cells. Data reported here indicate that the different interstitial compartments of the developing kidney are formed by different cell types that characterize the different renal areas. Further studies are needed to better characterize the different pools of renal interstitial progenitors and their role in human nephrogenesis.
authors: a Division of Pathology , Department of Surgical Sciences, University of Cagliari , Cagliari , Italy .
authors: Daniela
authors: D
authors: Fanni
authors: a Division of Pathology , Department of Surgical Sciences, University of Cagliari , Cagliari , Italy .
authors: Clara
authors: C
authors: Gerosa
authors: a Division of Pathology , Department of Surgical Sciences, University of Cagliari , Cagliari , Italy .
authors: Laura
authors: L
authors: Vinci
authors: a Division of Pathology , Department of Surgical Sciences, University of Cagliari , Cagliari , Italy .
authors: Rossano
authors: R
authors: Ambu
authors: b Department of Surgical Sciences , NICU Center and Puericulture Institute and Neonatal Section, University of Cagliari , Cagliari , Italy , and.
authors: Angelica
authors: A
authors: Dessì
authors: c Department of Pathology , University Hospitals, KU , Leuven , Belgium.
authors: Peter Van
authors: PV
authors: Eyken
authors: b Department of Surgical Sciences , NICU Center and Puericulture Institute and Neonatal Section, University of Cagliari , Cagliari , Italy , and.
authors: Vassilios
authors: V
authors: Fanos
authors: a Division of Pathology , Department of Surgical Sciences, University of Cagliari , Cagliari , Italy .
authors: Gavino
authors: G
authors: Faa
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D047109:Fetal Development; D006801:Humans; D007668:Kidney / Q000166:cytology* / Q000196:embryology* / Q000648:ultrastructure; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D055153:Stem Cell Niche / Q000502:physiology*
keywords: Development; fetus; human kidney; interstitial progenitors