title: Modelling approaches for evaluating multiscale tendon mechanics.
abstract: Tendon exhibits anisotropic, inhomogeneous and viscoelastic mechanical properties that are determined by its complicated hierarchical structure and varying amounts/organization of different tissue constituents. Although extensive research has been conducted to use modelling approaches to interpret tendon structure-function relationships in combination with experimental data, many issues remain unclear (i.e. the role of minor components such as decorin, aggrecan and elastin), and the integration of mechanical analysis across different length scales has not been well applied to explore stress or strain transfer from macro- to microscale. This review outlines mathematical and computational models that have been used to understand tendon mechanics at different scales of the hierarchical organization. Model representations at the molecular, fibril and tissue levels are discussed, including formulations that follow phenomenological and microstructural approaches (which include evaluations of crimp, helical structure and the interaction between collagen fibrils and proteoglycans). Multiscale modelling approaches incorporating tendon features are suggested to be an advantageous methodology to understand further the physiological mechanical response of tendon and corresponding adaptation of properties owing to unique in vivo loading environments.
authors: Department of Mechanical Engineering and Materials Science , Washington University in St Louis , St Louis, MO 63130 , USA.
authors: Fei
authors: F
authors: Fang
authors: Department of Mechanical Engineering and Materials Science, Washington University in St Louis, St Louis, MO 63130, USA; Department of Biomedical Engineering, Washington University in St Louis, St Louis, MO 63130, USA; Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO 63130, USA.
authors: Spencer P
authors: SP
authors: Lake
keywords: computational modelling; mathematical modelling; mechanical properties; multiscale; tendon