title: Amyloid precursor protein and amyloid precursor-like protein 2 in cancer.
abstract: Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.
authors: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Poomy
authors: P
authors: Pandey
authors: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Bailee
authors: B
authors: Sliker
authors: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.|Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Haley L
authors: HL
authors: Peters
authors: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.|Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.|Wellcome Trust/DBT India Alliance Intermediate Fellow, CSIR-Institute of Microbial Technology, Chandigarh, India.
authors: Amit
authors: A
authors: Tuli
authors: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Jonathan
authors: J
authors: Herskovitz
authors: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Kaitlin
authors: K
authors: Smits
authors: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Abhilasha
authors: A
authors: Purohit
authors: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.|Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Rakesh K
authors: RK
authors: Singh
authors: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.|Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Jixin
authors: J
authors: Dong
authors: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.|Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Surinder K
authors: SK
authors: Batra
authors: Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.|Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Donald W
authors: DW
authors: Coulter
authors: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.|Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.|Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.|Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Joyce C
authors: JC
authors: Solheim
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D058767:Protein Unfolding
chemical_list: C084104:APLP2 protein, human; D016564:Amyloid beta-Protein Precursor; D009419:Nerve Tissue Proteins
keywords: amyloid precursor protein; amyloid precursor-like protein 2; cancer; growth; migration