title: Novel strategies for the synthesis of unsymmetrical glycosyl disulfides.
abstract: Novel strategies for the efficient synthesis of unsymmetrical glycosyl disulfides are reported. Glycosyl disulfides are increasingly important as glycomimetics and molecular probes in glycobiology. Sialosyl disulfides are synthesised directly from the chlorosialoside Neu5Ac2Cl, proceeding via a thiol-disulfide exchange reaction between the sialosyl thiolate and symmetrical disulfides. This methodology was adapted and found to be successfully applicable to the synthesis of unsymmetrical glucosyl disulfides under mild conditions.
authors: Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK. r.a.falconer1@bradford.ac.uk gribeiro@bradford.ac.uk.
authors: Goreti Ribeiro
authors: GR
authors: Morais
authors: Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK. r.a.falconer1@bradford.ac.uk gribeiro@bradford.ac.uk.
authors: Bradley R
authors: BR
authors: Springett
authors: Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK. r.a.falconer1@bradford.ac.uk gribeiro@bradford.ac.uk.
authors: Martin
authors: M
authors: Pauze
authors: Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK. r.a.falconer1@bradford.ac.uk gribeiro@bradford.ac.uk.
authors: Lisa
authors: L
authors: Schröder
authors: Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK. r.a.falconer1@bradford.ac.uk gribeiro@bradford.ac.uk.
authors: Matthew
authors: M
authors: Northrop
authors: Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK. r.a.falconer1@bradford.ac.uk gribeiro@bradford.ac.uk.
authors: Robert A
authors: RA
authors: Falconer
mesh_terms: D002236:Carbohydrate Conformation; D004220:Disulfides / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation
chemical_list: D004220:Disulfides