title: Headspace Microextraction of Sulfonamides from Honey by Hollow Fibers Coupled with Ultrasonic Nebulization.
abstract: A new method for the rapid simultaneous determination of five sulfonamides in honey was developed using ultrasonic nebulization-assisted extraction coupled with hollow fiber liquid-liquid-liquid microextraction prior to liquid chromatography. In the present method, the sample solution was nebulized by ultrasonication. Sulfonamides in the aerosol particles were extracted by 1-octanol impregnated in the pores of a hollow fiber and further into the acceptor phase (acid solution, pH 2.0) contained in the lumen of the hollow fiber. Several experimental parameters that affect the extraction efficiency were optimized. The present method provides good recoveries (88.9-114.2%) and acceptable precision (<10.7%), indicating the effective extraction. The detection limits were 4.6-6.8 μg/kg, lower than the maximum residue limits of sulfonamides in honeys. Compared to the traditional extraction methods, the present method requires less organic solvent and operation time, demonstrating excellent cleanup ability and good enrichment efficiency.
authors: Jilin Ginseng Academy, Changchun University of Chinese Medicine , Changchun 130117, China.|Department of Chemistry, Jilin University , Changchun 130012, China.
authors: Rui
authors: R
authors: Su
authors: Department of Chemistry, Jilin University , Changchun 130012, China.
authors: Xueyuan
authors: X
authors: Li
authors: Jilin Ginseng Academy, Changchun University of Chinese Medicine , Changchun 130117, China.
authors: Wenlong
authors: W
authors: Liu
authors: Department of Chemistry, Jilin University , Changchun 130012, China.
authors: Xinghua
authors: X
authors: Wang
authors: Jilin Ginseng Academy, Changchun University of Chinese Medicine , Changchun 130117, China.|Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China.
authors: Hongmei
authors: H
authors: Yang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification*; D001516:Bees; D002851:Chromatography, High Pressure Liquid; D006722:Honey / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D059627:Liquid Phase Microextraction / Q000295:instrumentation / Q000379:methods*; D013449:Sulfonamides / Q000032:analysis / Q000302:isolation & purification*; D014465:Ultrasonics / Q000295:instrumentation / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents; D013449:Sulfonamides
keywords: headspace microextraction; hollow fiber; honey; sulfonamides; ultrasonic nebulization