title: Whole-Heart Construct Cultivation Under 3D Mechanical Stimulation of the Left Ventricle.
abstract: Today the concept of Whole-Heart Tissue Engineering represents one of the most promising approaches to the challenge of synthesizing functional myocardial tissue. At the current state of scientific and technological knowledge it is a principal task to transfer findings of several existing and widely investigated models to the process of whole-organ tissue engineering. Hereby, we present the first bioreactor system that allows the integrated 3D biomechanical stimulation of a whole-heart construct while allowing for simultaneous controlled perfusion of the coronary system.
authors: Research Group for Experimental Surgery, Department of Cardiovascular Surgery, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany.
authors: Jörn
authors: J
authors: Hülsmann
authors: Research Group for Experimental Surgery, Department of Cardiovascular Surgery, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany.
authors: Hug
authors: H
authors: Aubin
authors: Research Group for Experimental Surgery, Department of Cardiovascular Surgery, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany.
authors: Alexander
authors: A
authors: Wehrmann
authors: Research Group for Experimental Surgery, Department of Cardiovascular Surgery, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany.
authors: Alexander
authors: A
authors: Jenke
authors: Research Group for Experimental Surgery, Department of Cardiovascular Surgery, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany. Artur.Lichtenberg@med.uni-duesseldorf.de.
authors: Artur
authors: A
authors: Lichtenberg
authors: Research Group for Experimental Surgery, Department of Cardiovascular Surgery, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany.
authors: Payam
authors: P
authors: Akhyari
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D019149:Bioreactors; D002470:Cell Survival; D003331:Coronary Vessels / Q000166:cytology* / Q000502:physiology; D004867:Equipment Design; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles / Q000166:cytology*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D009924:Organ Culture Techniques / Q000295:instrumentation / Q000379:methods*; D010477:Perfusion / Q000295:instrumentation / Q000379:methods; D017208:Rats, Wistar; D013314:Stress, Mechanical; D013718:Tensile Strength; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*
keywords: 3D stretching; Biomechanical stimulation; Myocardial tissue engineering; Whole heart bioreactor; Whole-organ tissue engineering