title: Single and Combined Exposure to Zinc- and Copper-Containing Welding Fumes Lead to Asymptomatic Systemic Inflammation.
abstract: OBJECTIVE
  Recently, it has been shown that exposure to welding fumes containing both zinc and copper leads to asymptomatic systemic inflammation in humans as shown by an increase of blood C-reactive protein. In the present study, it was investigated which metal is responsible for this effect.
  
  
  METHODS
  Fifteen healthy male subjects were exposed under controlled conditions to welding fumes containing either zinc, or copper, or copper and zinc.
  
  
  RESULTS
  For each exposure blood C-reactive protein increased.
  
  
  CONCLUSIONS
  Copper- and zinc-containing welding fumes are able to induce systemic inflammation.
authors: Institute for Occupational and Social Medicine (Markert, Dr Baumann, Dr Gube, Ms Kossack, Dr Kraus, Dr Brand), and ISF-Welding and Joining Institute (Mr Gerhards), RWTH Aachen University, Germany.
authors: Agnieszka
authors: A
authors: Markert
authors: Ralf
authors: R
authors: Baumann
authors: Benjamin
authors: B
authors: Gerhards
authors: Monika
authors: M
authors: Gube
authors: Veronika
authors: V
authors: Kossack
authors: Thomas
authors: T
authors: Kraus
authors: Peter
authors: P
authors: Brand
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003300:Copper / Q000633:toxicity*; D018592:Cross-Over Studies; D064368:Healthy Volunteers; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D016273:Occupational Exposure / Q000009:adverse effects; D014896:Welding; D015032:Zinc / Q000633:toxicity*
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D003300:Copper; D002097:C-Reactive Protein; D015032:Zinc