title: Human dermal fibroblasts in psychiatry research.
abstract: In order to decipher the disease etiology, progression and treatment of multifactorial human brain diseases we utilize a host of different experimental models. Recently, patient-derived human dermal fibroblast (HDF) cultures have re-emerged as promising in vitro functional system for examining various cellular, molecular, metabolic and (patho)physiological states and traits of psychiatric disorders. HDF studies serve as a powerful complement to postmortem and animal studies, and often appear to be informative about the altered homeostasis in neural tissue. Studies of HDFs from patients with schizophrenia (SZ), depression, bipolar disorder (BD), autism, attention deficit and hyperactivity disorder and other psychiatric disorders have significantly advanced our understanding of these devastating diseases. These reports unequivocally prove that signal transduction, redox homeostasis, circadian rhythms and gene*environment (G*E) interactions are all amenable for assessment by the HDF model. Furthermore, the reported findings suggest that this underutilized patient biomaterial, combined with modern molecular biology techniques, may have both diagnostic and prognostic value, including prediction of response to therapeutic agents.
authors: Department of Psychiatry, University of Szeged, 57 Kálvária Sgt, Szeged 6725, Hungary. Electronic address: kalmansara@gmail.com.
authors: S
authors: S
authors: Kálmán
authors: Department of Psychiatry, Vanderbilt University, 8128 MRB III, 465 21st Avenue, Nashville, TN 37232, USA. Electronic address: krassimira.garbett@vanderbilt.edu.
authors: K A
authors: KA
authors: Garbett
authors: Department of Psychiatry, University of Szeged, 57 Kálvária Sgt, Szeged 6725, Hungary. Electronic address: janka.zoltan@med.u-szeged.hu.
authors: Z
authors: Z
authors: Janka
authors: Department of Psychiatry, University of Szeged, 57 Kálvária Sgt, Szeged 6725, Hungary; Department of Psychiatry, Vanderbilt University, 8128 MRB III, 465 21st Avenue, Nashville, TN 37232, USA. Electronic address: karoly.mirnics@vanderbilt.edu.
authors: K
authors: K
authors: Mirnics
mesh_terms: D035843:Biomedical Research / Q000379:methods; D002478:Cells, Cultured; D005347:Fibroblasts; D006801:Humans; D001523:Mental Disorders; D008954:Models, Biological; D011570:Psychiatry / Q000379:methods*; D012867:Skin
keywords: bipolar disorder; dermal fibroblasts; gene*environment interaction; in vitro model; major depression; schizophrenia