title: Pyroacm Resin: An Acetamidomethyl Derived Resin for Solid Phase Synthesis of Peptides through Side Chain Anchoring of C-Terminal Cysteine Residues.
abstract: The design, synthesis and utilization of an efficient acetamidomethyl derived resin for the peptide synthesis is presented using established Fmoc and Boc protocols via side chain anchoring. Cleavage of the target peptide from the resin is performed using carboxymethylsulfenyl chloride under mild conditions which gave in situ thiol-sulfenyl protection of the cysteine residues. The utility of the resin is successfully demonstrated through applications to the syntheses of model peptides and natural products Riparin 1.1 and Riparin 1.2.
authors: Innovative Drug Library Research Center, Dongguk University , Seoul 100-715, South Korea.
authors: Vinayak
authors: V
authors: Juvekar
authors: Innovative Drug Library Research Center, Dongguk University , Seoul 100-715, South Korea.
authors: Young Dae
authors: YD
authors: Gong
mesh_terms: D003545:Cysteine / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012116:Resins, Plant / Q000737:chemistry* / Q000302:isolation & purification; D060327:Solid-Phase Synthesis Techniques; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D010455:Peptides; D012116:Resins, Plant; D013438:Sulfhydryl Compounds; D003545:Cysteine