title: 5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents.
abstract: In spite of tremendous advancement in the field of cancer therapy, it is still one of the leading causes of death worldwide. One of the newest targets in the field of cancer therapeutics is 5'Adenosine Mono Phosphate activated protein kinase (AMPK). In vitro and in vivo evidences suggest anti-cancer activity of AMPK. AMPK activation may promote catabolism while preventing the anabolic processes of cell. Thus it may modulate cellular protein and lipid metabolism and affect the growth and division of cell. Here we review the mechanisms of action of AMPK modulators as future anti-cancer agents.
authors: Abhishek
authors: A
authors: Thakur
authors: Nirnoy
authors: N
authors: Dan
authors: Soumendranath
authors: S
authors: Bhakat
authors: Venkatesan
authors: V
authors: Jayaprakash
authors: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi: 835215.
authors: Sugato
authors: S
authors: Banerjee
keywords: AMPK; anti-cancer; diabetes; natural; synthetic