title: Hot Topics in Primary Care: Role of the Kidney and SGLT-2 Inhibition in Type 2 Diabetes Mellitus.
abstract: SGLT-2 inhibitors provide a complementary mechanism of glucose lowering and can be used as monotherapy or in combination with other medications, including insulin. In addition to improved glycemic control, which generally is maintained over 2 years, SGLT-2 inhibitors provide reductions in body weight and systolic blood pressure. Increases in LDL-C and HDL-C also have been observed. A requirement for adequate renal function is a limitation in patients with CKD. A low incidence of hypoglycemia, ability to promote weight loss, and availability as an oral formulation diminish common barriers to glucose-lowering therapy.
authors: Executive Director and Co-founder, Diabetes Nation, High Lakes Health Care, St. Charles Hospital, Bend, OR, USA.
authors: Kevin
authors: K
authors: Miller
authors: Executive Director and Co-founder, Diabetes Nation, High Lakes Health Care, St. Charles Hospital, Bend, OR, USA.
authors: Eden M
authors: EM
authors: Miller
mesh_terms: D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D000068896:Canagliflozin / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism; D005960:Glucosides / Q000627:therapeutic use*; D006706:Homeostasis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D011320:Primary Health Care / Q000379:methods; D051297:Sodium-Glucose Transporter 2 / Q000378:metabolism; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D016896:Treatment Outcome
chemical_list: D001559:Benzhydryl Compounds; D015415:Biomarkers; D005960:Glucosides; D007004:Hypoglycemic Agents; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D000068896:Canagliflozin; C529054:dapagliflozin; C570240:empagliflozin; D005947:Glucose