title: Luminescence- and nanoparticle-mediated increase of light absorption by photoreceptor cells: Converting UV light to visible light.
abstract: We developed new optic devices - singly-doped luminescence glasses and nanoparticle-coated lenses that convert UV light to visible light - for improvement of visual system functions. Tb(3+) or Eu(3+) singly-doped borate glasses or CdS-quantum dot (CdS-QD) coated lenses efficiently convert UV light to 542 nm or 613 nm wavelength narrow-band green or red light, or wide-spectrum white light, and thereby provide extra visible light to the eye. In zebrafish (wild-type larvae and adult control animals, retinal degeneration mutants, and light-induced photoreceptor cell degeneration models), the use of Tb(3+) or Eu(3+) doped luminescence glass or CdS-QD coated glass lenses provide additional visible light to the rod and cone photoreceptor cells, and thereby improve the visual system functions. The data provide proof-of-concept for the future development of optic devices for improvement of visual system functions in patients who suffer from photoreceptor cell degeneration or related retinal diseases.
authors: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
authors: Lei
authors: L
authors: Li
authors: Department of Physics, and Center for Security Advances via Applied Nanotechnology, University of Texas, Arlington, TX 76019, USA.
authors: Sunil K
authors: SK
authors: Sahi
authors: The State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, China 510641.
authors: Mingying
authors: M
authors: Peng
authors: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
authors: Eric B
authors: EB
authors: Lee
authors: Department of Physics, and Center for Security Advances via Applied Nanotechnology, University of Texas, Arlington, TX 76019, USA.
authors: Lun
authors: L
authors: Ma
authors: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
authors: Jennifer L
authors: JL
authors: Wojtowicz
authors: Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
authors: John H
authors: JH
authors: Malin
authors: The State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, China 510641.
authors: Wei
authors: W
authors: Chen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008027:Light; D053758:Nanoparticles / Q000528:radiation effects*; D055096:Optical Devices; D010786:Photoreceptor Cells / Q000502:physiology* / Q000528:radiation effects*; D012162:Retinal Degeneration; D014466:Ultraviolet Rays; D015027:Zebrafish