title: Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain.
abstract: Previous in vitro and in vivo studies demonstrated that HIV protein nef plays a key role in impairing cellular and systemic cholesterol metabolism in HIV disease, but clinical support for these findings is lacking. Here we present the data of comparative lipidomic analysis (330 lipid species) of plasma samples from HIV-negative subjects, patients infected with WT HIV-1 strain and patients infected with nef-deficient strain of HIV-1. We determine which effects of HIV on plasma lipidome are explained by the presence of nef. The data can be used to evaluate cardiovascular risk in HIV disease and to assess the role of nef in HIV-induced disturbances in systemic lipid metabolism. The full impact of nef deficiency on lipid and lipoprotein metabolism in HIV-infected patients is presented in the accompanying study "Lipid Metabolism in Patients Infected with Nef-deficient HIV-1 Strain" [1].
authors: Baker IDI Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC 3004, Australia.
authors: Peter
authors: P
authors: Meikle
authors: Baker IDI Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC 3004, Australia.
authors: Hann
authors: H
authors: Low
authors: Macfarlane Burnett Institute for Medical Research and Public Health, 85 Commercial Rd, Melbourne, VIC 3004, Australia.
authors: Melissa J
authors: MJ
authors: Churchill
authors: Department of Microbiology, Immunology and Tropical Medicine, George Washington University, 2300 I St. NW, Ross Hall, Washington DC 20037, USA.
authors: Michael
authors: M
authors: Bukrinsky
authors: Baker IDI Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC 3004, Australia.
authors: Dmitri
authors: D
authors: Sviridov