title: Non-invasive assessment of liver fibrosis using acoustic structure quantification: comparison with transient elastography in chronic viral hepatitis.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the diagnostic efficacy of acoustic structure quantification (ASQ) parameters [mode, average, and focal distribution (FD) ratio] in the staging of hepatic fibrosis in patients with chronic viral hepatitis and to compare it with transient elastography (TE) by using liver biopsy as reference standard.
  
  
  METHODS
  We studied 62 patients with chronic viral hepatitis. Each patient underwent ASQ evaluation and liver biopsy; 54 of these patients received TE. Thirty-six participants without any liver disease were enrolled as normal group, who also underwent ASQ evaluation and TE. All three parameters of ASQ were compared with the histologic fibrosis grade according to the METAVIR scoring (F0-F4). Statistical analysis was performed to investigate the correlations and the diagnostic values of ASQ parameters and compare them to TE.
  
  
  RESULTS
  All three ASQ parameters and TE were significantly correlated with liver fibrosis stage. Of the ASQ parameters, the mode parameter showed the best correlation (P < 0.001). On the area under the receiver operating characteristic curve (AUROC), the mode parameter of ASQ analysis showed both significant correlation and good accuracy for diagnosis of F ≥ 1, F ≥ 2, and F ≥ 3. These values were significantly better than those of the average and FD ratio parameters in F ≥ 1 and F ≥ 2 (P < 0.05). There was no statistically significant difference in AUROC between the mode parameter and TE in diagnosis of F ≥ 1, F ≥ 2, or F ≥ 3.
  
  
  CONCLUSIONS
  The mode parameter is the most reliable ASQ parameter, comparable to TE, as a non-invasive method for the detection and grading of liver fibrosis in patients with chronic viral hepatitis.
authors: Department of Radiology, Anam Hospital, Korea University College of Medicine, 126-1 5-Ka, Anam-Dong, Sungbuk-ku, Seoul, 136-705, Korea.
authors: Tae-Hoon
authors: TH
authors: Nam
authors: Department of Radiology, Anam Hospital, Korea University College of Medicine, 126-1 5-Ka, Anam-Dong, Sungbuk-ku, Seoul, 136-705, Korea. radiolbj226@gmail.com.
authors: Beom Jin
authors: BJ
authors: Park
authors: Department of Radiology, Anam Hospital, Korea University College of Medicine, 126-1 5-Ka, Anam-Dong, Sungbuk-ku, Seoul, 136-705, Korea.
authors: Deuk Jae
authors: DJ
authors: Sung
authors: Department of Radiology, Anam Hospital, Korea University College of Medicine, 126-1 5-Ka, Anam-Dong, Sungbuk-ku, Seoul, 136-705, Korea.
authors: Min Ju
authors: MJ
authors: Kim
authors: Department of Radiology, Anam Hospital, Korea University College of Medicine, 126-1 5-Ka, Anam-Dong, Sungbuk-ku, Seoul, 136-705, Korea.
authors: Na Yeon
authors: NY
authors: Han
authors: Department of Radiology, Anam Hospital, Korea University College of Medicine, 126-1 5-Ka, Anam-Dong, Sungbuk-ku, Seoul, 136-705, Korea.
authors: Ki Choon
authors: KC
authors: Sim
authors: Department of Radiology, University of Washington Medical Center, Seattle, WA, USA.
authors: Jean H
authors: JH
authors: Lee
authors: Department of Radiology, Anam Hospital, Korea University College of Medicine, 126-1 5-Ka, Anam-Dong, Sungbuk-ku, Seoul, 136-705, Korea.
authors: Sung Bum
authors: SB
authors: Cho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000821:virology*; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies
keywords: Acoustic structure quantification (ASQ); Liver fibrosis; Transient elastography (TE); Ultrasound