title: Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
abstract: This case-control study reports the association between nutrient intake and neovascular age-related macular degeneration (AMD) in Japan. The nutrient intake of 161 neovascular AMD cases from two university hospitals and 369 population-based control subjects from a cohort study was assessed using a brief-type self-administered questionnaire on diet history, which required respondent recall of the usual intake of 58 foods during the preceding month. Energy-adjusted nutrient intake values were compared between the groups. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% CIs adjusted for smoking history, age, sex, chronic disease history, supplement use, and alcohol consumption. Logistic regression analysis demonstrated that low intakes of n-3 fatty acid, α-tocopherol, zinc, vitamin D, vitamin C, and β-carotene were associated with neovascular AMD (Trend P < 0.0001 for n-3 fatty acid, Trend P < 0.0001 for α-tocopherol, Trend P < 0.0001 for zinc, Trend P = 0.002 for vitamin D, Trend P = 0.04 for vitamin C, Trend P = 0.0004 for β-carotene). There was no association with retinol or cryptoxanthin intake and neovascular AMD (P = 0.67, 0.06).
authors: Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.|Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors: Aya
authors: A
authors: Aoki
authors: Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
authors: Maiko
authors: M
authors: Inoue
authors: Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan.
authors: Elizabeth
authors: E
authors: Nguyen
authors: Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Ryo
authors: R
authors: Obata
authors: Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
authors: Kazuaki
authors: K
authors: Kadonosono
authors: Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors: Shoji
authors: S
authors: Shinkai
authors: Department of Health Economics and Epidemiology Research, University of Tokyo School of Public Health, Tokyo, Japan.
authors: Hideki
authors: H
authors: Hashimoto
authors: Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan.
authors: Satoshi
authors: S
authors: Sasaki
authors: Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.|Singapore National Eye Center, 11 Third Hospital Ave, Singapore 168751.|Singapore Eye Research Institute, 11 Third Hospital Ave, Singapore 168751.
authors: Yasuo
authors: Y
authors: Yanagi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001205:Ascorbic Acid / Q000008:administration & dosage*; D016022:Case-Control Studies; D019587:Dietary Supplements; D002149:Energy Intake; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007564:Japan; D016015:Logistic Models; D008268:Macular Degeneration / Q000453:epidemiology*; D008297:Male; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000008:administration & dosage*; D015032:Zinc / Q000008:administration & dosage*; D024502:alpha-Tocopherol / Q000008:administration & dosage*; D019207:beta Carotene / Q000008:administration & dosage*
chemical_list: D015525:Fatty Acids, Omega-3; D019207:beta Carotene; D014807:Vitamin D; D024502:alpha-Tocopherol; D015032:Zinc; D001205:Ascorbic Acid