title: Role of lectin microarrays in cancer diagnosis.
abstract: The majority of cell differentiation associated tumor markers reported to date are either glycoproteins or glycolipids. Despite there being a large number of glycoproteins reported as candidate markers for various cancers, only a handful are approved by the US Food and Drug Administration. Lectins, which bind to the glycan part of the glycoproteins, can be exploited to identify aberrant glycosylation patterns, which in turn would help in enhancing the specificity of cancer diagnosis. Although conventional techniques such as HPLC and MS have been instrumental in performing the glycomic analyses, these techniques lack multiplexity. Lectin microarrays have proved to be useful in studying multiple lectin-glycan interactions in a single experiment and, with the advances made in the field, hold a promise of enabling glycomic profiling of cancers in a fast and efficient manner.
authors: Department of Biochemistry/Biotechnology, University of Turku, Turun yliopisto, Finland.
authors: Parvez
authors: P
authors: Syed
authors: Department of Biochemistry/Biotechnology, University of Turku, Turun yliopisto, Finland.
authors: Kamlesh
authors: K
authors: Gidwani
authors: Department of Biochemistry/Biotechnology, University of Turku, Turun yliopisto, Finland.
authors: Henna
authors: H
authors: Kekki
authors: Department of Biochemistry/Biotechnology, University of Turku, Turun yliopisto, Finland.
authors: Janne
authors: J
authors: Leivo
authors: Department of Biochemistry/Biotechnology, University of Turku, Turun yliopisto, Finland.
authors: Kim
authors: K
authors: Pettersson
authors: Department of Biochemistry/Biotechnology, University of Turku, Turun yliopisto, Finland.
authors: Urpo
authors: U
authors: Lamminmäki
mesh_terms: D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism; D011134:Polysaccharides / Q000378:metabolism*; D040081:Protein Array Analysis / Q000379:methods*; D011485:Protein Binding; D040901:Proteomics / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D006023:Glycoproteins; D037102:Lectins; D011134:Polysaccharides
keywords: Cancer biomarkers; Glycans; Glycoproteins; Lectin microarray; Lectins; Protein arrays