title: Concentration Study of High Sensitive C - reactive Protein and some Serum Trace Elements in Patients with Benign and Malignant Breast Tumor.
abstract: Background : Breast cancer is the most common invasive cancer in females worldwide. It accounts for 16% of all female cancers and 22.9% of invasive cancers in women. 18.2% of all cancer deaths worldwide including both males and females are from breast cancer. In this study we compared few serum elements in patients with benign and malignant breast tumor to find any related prognostic and predictive value.
  
  
  METHODS
  A case-control study was carried out in a hospital (Tehran - Iran) in 2012. Target population was divided in 2 groups; subjects with benign and malignant breast tumors. We did preoperative hematological test. Five milliliter fasting blood vein was collected, centrifuged in 3000 g for 15 minutes to obtain serum. We measured serum Calcium (Ca), Phosphorus (P), Magnesium (Mg), Zinc (Zn), and high sensitive-CRP, analyzed statistically and compared recorded elements in 2 groups by software package SPSS version 16. The level of significant was considered P < 0.05.
  
  
  RESULTS
  Of 87 women, 49 cases with benign breast disease (group A) and 38 cases with breast cancer (group B) entered our study. Serum concentration of Ca, mg, and P in group A were higher than group B, however these differences were not significant. We found no significant correlation between serum Zn and type of tumor in our patients. On the other hand, a significant elevation in hs-CRP in patient with breast cancer was seen (P Value=.000). Conclusion : Our results have shown similar concentration of Ca, Mg, Zn, P and completely different hs-CRP concentration in patients with benign and malignant breast disease.
authors: Associate Professor of Pathology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical sciences. Tehran, Iran.
authors: Alireza
authors: A
authors: Abdollahi
authors: Assistant Professor of Surgery, Imam Khomeini Hospital Complex, Vali-Asr Hospital, Surgery Ward, Tehran University Medical of sciences Tehran, Iran.
authors: Abbas
authors: A
authors: Ali-Bakhshi
authors: Physiologists, Maternal Fetal and Neonatal Research Center, Tehran University Medical of Sciences, Tehran, Iran.
authors: Zahra
authors: Z
authors: Farahani
keywords: Benign and Malignant breast tumor; Trace element; hs-CRP