title: Successful mucosal incision-assisted biopsy for the histological diagnosis of duodenal lymphoma: A case report.
abstract: Tissue sampling of primary duodenal lymphoma is essential for its histological diagnosis. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), which is frequently used for submucosal tumor (SMT)-like duodenal tumors, is adequate for cytological diagnosis, but not for histological diagnosis. Therefore, in the present study, a mucosal incision-assisted biopsy (MIAB) was performed in an 81-year-old woman for the diagnosis of an SMT-like duodenal mass, as tissue sampling for histological analysis using a regular endoscopic biopsy had failed to establish a definite diagnosis of malignant lymphoma. EUS-FNA had also led to poor tissue sampling due to the difficult location of the duodenal tumor. The pathological examination of biopsy samples using MIAB revealed the presence of a diffuse proliferation of atypical lymphocytes, and the expression of cluster of differentiation (CD)20 and CD79a, but no expression of CD3 in the tumor specimens. The patient was diagnosed with diffuse large B-cell lymphoma. To the best of knowledge, this is first report of a case using MIAB as a sampling method for the histological diagnosis of SMT-like primary duodenal lymphoma. This case suggests that MIAB may be an essential method for obtaining tissue samples from SMT-like duodenal tumors.
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Asahiro
authors: A
authors: Morishita
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Hirohito
authors: H
authors: Mori
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Hideki
authors: H
authors: Kobara
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Noriko
authors: N
authors: Nishiyama
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Shintaro
authors: S
authors: Fujihara
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Tatsuo
authors: T
authors: Yachida
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Maki
authors: M
authors: Ayaki
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Tae
authors: T
authors: Matsunaga
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Teppei
authors: T
authors: Sakamoto
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Emiko
authors: E
authors: Maeda
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Takako
authors: T
authors: Nomura
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Joji
authors: J
authors: Tani
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Hisaaki
authors: H
authors: Miyoshi
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Hirohito
authors: H
authors: Yoneyama
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Takashi
authors: T
authors: Himoto
authors: Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Seiko
authors: S
authors: Kagawa
authors: Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Reiji
authors: R
authors: Haba
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan.
authors: Tsutomu
authors: T
authors: Masaki
keywords: duodenal lymphoma; endoscopic ultrasound-guided fine-needle aspiration; histological diagnosis; mucosal incision-assisted biopsy; submucosal tumor