title: Radiation-Induced Breast Angiosarcoma: Case Report and Clinical Approach.
abstract: OBJECTIVE
  Radiation-induced angiosarcoma after conservative treatment of breast cancer affects a small percentage of patients but has a significant impact on survival. Early detection requires a high index of suspicion and is important for optimal management of this aggressive disease.
  
  
  METHODS
  The patient reported here presented with radiation-induced angiosarcoma of the left breast 14 years after radiation therapy. Histopathology was positive for anti-CD31, anti-CD34, D2-40, and anti-factor VIII (von Willebrand). She underwent a total mastectomy and is still in remission 20 months later. The authors present a review of the clinical presentation, diagnostic methods, and treatment options.
  
  
  CONCLUSIONS
  This case report demonstrates the importance of long-term follow-up and investigation of even the subtlest cutaneous changes in the breast after radiation treatment, because radiation-induced angiosarcoma is a very aggressive disease that could benefit from early diagnosis and management.
authors: Université de Sherbrooke, Sherbrooke, QC, Canada cbruspeterson@gmail.com.
authors: Cheryl Brus
authors: CB
authors: Peterson
authors: Université de Sherbrooke, Sherbrooke, QC, Canada.
authors: Solange
authors: S
authors: Beauregard
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*
keywords: cancer; dermatology