title: New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate.
abstract: As many substances are poorly soluble in water and thus possess decreased bioavailability, creating orally administered forms of these substances is a challenge. The objective of this study was to determine whether the solubility of megestrol acetate, a Biopharmaceutical Classification System (BCS) class II drug, can be improved by using a newly-synthesized surfactant (Rofam 70: a rapeseed methyl ester ethoxylate) and compare it with two references surfactants (Tween 80, Pluronic F68) at three different pH values. Spectrophotometry was used to compare the solubility profiles in the presence of three tested surfactants at pH 5.0, 7.4 and 9.0. Rapeseed methyl ester ethoxylate was found to improve the solubility of the BCS Class II drug and increase its bioavailability; It increased drug solubility more effectively than Pluronic F68. Its cytotoxicity results indicate its possible value as a surfactant in Medicine and Pharmacy.
authors: Department of Applied Pharmacy, Medical University of Lodz, ul. Muszy´ nskiego 1, Lodz 90-151, Poland. malwina.lachowicz@umed.lodz.pl.
authors: Malwina
authors: M
authors: Lachowicz
authors: Department of Applied Pharmacy, Medical University of Lodz, ul. Muszy´ nskiego 1, Lodz 90-151, Poland. michal.kolodziejczyk@umed.lodz.pl.
authors: Michał
authors: M
authors: Kołodziejczyk
authors: Surface-Active Agent Plant "ICSO Blachownia", ul. Energetyków 9, K˛edzierzyn-Ko´zle 47-225, Poland. lukosek.m@icso.com.pl.
authors: Marek
authors: M
authors: Lukosek
authors: Surface-Active Agent Plant "ICSO Blachownia", ul. Energetyków 9, K˛edzierzyn-Ko´zle 47-225, Poland. kosno.j@icso.com.pl.
authors: Jacek
authors: J
authors: Kosno
authors: Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, ul. Muszy´ nskiego 1, Lodz 90-151, Poland. paulina.olszewska@umed.lodz.pl.
authors: Paulina
authors: P
authors: Olszewska
authors: Laboratory of Radiopharmacy, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, ul. Muszy´ nskiego 1, Lodz 90-151, Poland. pawel.szymanski@umed.lodz.pl.
authors: Paweł
authors: P
authors: Szyma Nski
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D019290:Megestrol Acetate / Q000737:chemistry* / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D001704:Biopolymers; D011136:Polysorbates; D013501:Surface-Active Agents; D020442:Poloxamer; D019290:Megestrol Acetate
keywords: Tween 80; megestrol acetate; nanoparticles; solubilization; surfactant