title: Dendritic cell function and antigen presentation in malaria.
abstract: Due to the diverse roles T cells play in protection against malaria as well as pathogenesis it is critical to know which cells present antigen and the nature of the antigens they present. During pre-erythrocytic stages of infection, cutting-edge imaging studies have shown how Plasmodium antigens are presented during both the priming and effector phases of the protective CD8+ T cell response. During blood stages, pathology is in part due to the loss of DC function and the action of pathogenic T cells in the brain. Recently endothelial cells presenting malaria antigen to cognate T cells have emerged as critical players in malaria pathogenesis. Manipulating these processes may inform both vaccine design and the development of therapies for cerebral malaria.
authors: Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia. Electronic address: ian.cockburn@anu.edu.au.
authors: Ian A
authors: IA
authors: Cockburn
authors: Department of Medical Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, United States.
authors: Fidel
authors: F
authors: Zavala
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D001921:Brain / Q000473:pathology; D016827:CD8 Antigens / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000469:parasitology; D045142:Cross-Priming; D003713:Dendritic Cells / Q000276:immunology* / Q000469:parasitology; D042783:Endothelial Cells / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D008018:Life Cycle Stages; D008213:Lymphocyte Activation; D008288:Malaria / Q000276:immunology*; D017780:Malaria Vaccines / Q000276:immunology*; D010961:Plasmodium / Q000502:physiology*
chemical_list: D000953:Antigens, Protozoan; D016827:CD8 Antigens; C431698:CD8alpha antigen; D017780:Malaria Vaccines