title: Kartogenin-Incorporated Thermogel Supports Stem Cells for Significant Cartilage Regeneration.
abstract: Recently, cartilage tissue engineering (CTE) attracts increasing attention in cartilage defect repair. In this work, kartogenin (KGN), an emerging chondroinductive nonprotein small molecule, was incorporated into a thermogel of poly(L-lactide-co-glycolide)-poly(ethylene glycol)-poly(L-lactide-co-glycolide) (PLGA-PEG-PLGA) to fabricate an appropriate microenvironment of bone marrow mesenchymal stem cells (BMSCs) for effective cartilage regeneration. More integrative and smoother repaired articular surface, more abundant characteristic glycosaminoglycans (GAGs) and collagen II (COL II), and less degeneration of normal cartilage were obtained in the KGN and BMSCs coloaded thermogel group in vivo. In conclusion, the KGN-loaded PLGA-PEG-PLGA thermogel can be utilized as an alternative support for BMSCs to regenerate damaged cartilage in vivo.
authors: Department of Orthopaedics, The Second Hospital of Jilin University , Changchun 130041, People's Republic of China.
authors: Xuezhou
authors: X
authors: Li
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
authors: Jianxun
authors: J
authors: Ding
authors: Institute of Sports Medicine, Peking University Third Hospital , Beijing 100191, People's Republic of China.
authors: Zhengzheng
authors: Z
authors: Zhang
authors: Department of Orthopaedics, The Second Hospital of Jilin University , Changchun 130041, People's Republic of China.
authors: Modi
authors: M
authors: Yang
authors: Institute of Sports Medicine, Peking University Third Hospital , Beijing 100191, People's Republic of China.
authors: Jiakuo
authors: J
authors: Yu
authors: Department of Orthopaedics, The Second Hospital of Jilin University , Changchun 130041, People's Republic of China.
authors: Jincheng
authors: J
authors: Wang
authors: Department of Orthopaedics, The Second Hospital of Jilin University , Changchun 130041, People's Republic of China.
authors: Fei
authors: F
authors: Chang
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
authors: Xuesi
authors: X
authors: Chen
mesh_terms: D000813:Anilides / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D002356:Cartilage / Q000187:drug effects / Q000254:growth & development* / Q000473:pathology; D060833:Cellular Microenvironment / Q000187:drug effects; D003094:Collagen / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000187:drug effects; D010795:Phthalic Acids / Q000737:chemistry / Q000627:therapeutic use*; D011091:Polyesters / Q000737:chemistry / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000737:chemistry / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D012038:Regeneration / Q000187:drug effects*; D023822:Tissue Engineering
chemical_list: D000813:Anilides; D010795:Phthalic Acids; D011091:Polyesters; C000589473:polyethylene glycol-poly(lactide-co-glycolide); D011092:Polyethylene Glycols; D005337:Fibrin; D003094:Collagen; C572342:kartogenin
keywords: cartilage regeneration; kartogenin; mesenchymal stem cells; thermogel; tissue engineering