title: Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore.
abstract: Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological calcium overload leads to the membrane depolarization and disruption of ATP production. mPTP activation has been implicated as a central event during the process of stress-induced cell death. mPTP is a supramolecular complex composed of many proteins. Recent studies suggest that mitochondrial ATPase plays the central role in the formation of mPTP. However, the structure of the central conducting pore part of mPTP (mPTPore) remains elusive. Here we review current models proposed for the mPTPore and involvement of polyP in its formation and regulation. We discuss the underestimated role of polyP as an effector and a putative structural component of the mPTPore. We propose the hypothesis that inclusion of polyP can explain such properties of mPTP activity as calcium activation, selectivity and voltage-dependence.
authors: Department of Basic Sciences, New York University College of Dentistry, 345 East 24 Street, 10010, New York, NY, U.S.A.
authors: Maria E
authors: ME
authors: Solesio
authors: Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 4R2.
authors: Pia A
authors: PA
authors: Elustondo
authors: Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, 1 Illini Drive, 61605, Peoria, Il, U.S.A.
authors: Eleonora
authors: E
authors: Zakharian
authors: Department of Basic Sciences, New York University College of Dentistry, 345 East 24 Street, 10010, New York, NY, U.S.A.
authors: Evgeny V
authors: EV
authors: Pavlov
mesh_terms: D000818:Animals; D006801:Humans; D033681:Mitochondrial Membrane Transport Proteins / Q000737:chemistry* / Q000378:metabolism*; D000083162:Mitochondrial Permeability Transition Pore; D008954:Models, Biological; D011122:Polyphosphates / Q000378:metabolism*
chemical_list: D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D011122:Polyphosphates
keywords: calcium; inorganic polyphosphate (polyP); mitochondria; permeability transition