title: Monitoring recovery from rocuronium-induced neuromuscular block using acceleromyography at the trapezius versus the adductor pollicis muscle: an observational trial.
abstract: OBJECTIVE
  Positioning for surgery can restrict access to the patient's hand, thereby limiting assessment of the response at the adductor pollicis muscle to ulnar nerve stimulation. We evaluated a novel site to assess neuromuscular block by stimulating the accessory nerve and measuring the acceleromyographic response at the trapezius muscle.
  
  
  METHODS
  In this prospective non-blinded observational study, we assessed neuromuscular transmission in anesthetized adult female patients undergoing elective laparoscopic gynecological surgery. We performed the assessment by simultaneous recording acceleromyographic responses with the TOF-Watch(®) SX monitor at both the right adductor pollicis and left trapezius muscles. The neuromuscular block was achieved using rocuronium 0.3 mg·kg(-1), and the repeatability, time course, and limits of agreement (Bland-Altman) of responses were compared at the two recording sites. The primary endpoint was the 90% train-of-four (TOF) recovery time with other endpoints included the onset time of the block, maximum T1 depression, time to 25% T1 recovery, and recovery time course of the T1 response and TOF ratio.
  
  
  RESULTS
  Thirty-six patients were enrolled with responses obtained from 27 subjects. The variability of baseline responses recorded at the trapezius muscle was larger than that recorded at the adductor pollicis muscle, as determined by their mean (SD) repeatability coefficients [twitch height T1, 6.1 (1.9)% and 4.2 (1.6)%, respectively; P = 0.001; TOF ratio, 6.2 (2.1)% and 4.3 (1.7)%, respectively; P = 0.001]. The recorded responses showed relatively narrow limits of agreement. The onset time of the block was 0.3 min earlier at the trapezius muscle than at the adductor pollicis muscle [2.3 (0.8) min and 2.6 (0.7) min, respectively; P = 0.007], with limits of agreement ranging from 1.6 min earlier to 1.0 min later. The time to 25% T1 recovery was 1.8 min earlier at the trapezius muscle than at the adductor pollicis muscle [18.2 (5.7) min and 20.0 (5.2) min, respectively; P = 0.039], with limits of agreement ranging from 11.1 min earlier to 7.5 min later. Additionally, the time to achieve 90% TOF ratio was 4.4 min earlier at the trapezius muscle than at the adductor pollicis muscle [32.6 (7.9) min and 37 (9.1) min, respectively; P = 0.004], with limits of agreement ranging from 18.4 min earlier to 9.7 min later.
  
  
  CONCLUSIONS
  We conclude that recording evoked acceleromyographic responses at the trapezius muscle is an acceptable alternative when monitoring from the adductor pollicis muscle is compromised. Nevertheless, we caution that recording a 90% TOF response at the trapezius muscle may overestimate functional recovery from the neuromuscular blockade. This trial was registered at ClinicalTrials.gov identifier, NCT01849198.
authors: Department of Anesthesia and Intensive Care Medicine, KKH Dormagen, 41540, Dormagen, Germany. Stefan.soltesz@kkh-ne.de.
authors: Stefan
authors: S
authors: Soltesz
authors: Department of Anesthesia and Intensive Care Medicine, KKH Dormagen, 41540, Dormagen, Germany.
authors: Christian
authors: C
authors: Stark
authors: Department of Obstetrics and Gynecology, University of Witten-Herdecke, KKH Dormagen, Dormagen, Germany.
authors: Karl G
authors: KG
authors: Noé
authors: Department of Gynecology, KKH Dormagen, Dormagen, Germany.
authors: Michael
authors: M
authors: Anapolski
authors: Department of Anesthesia and Intensive Care Medicine, University of Rostock, Rostock, Germany.
authors: Thomas
authors: T
authors: Mencke
mesh_terms: D061725:Accelerometry / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000732:Androstanols; D000762:Anesthesia Recovery Period; D004558:Electric Stimulation / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D019148:Neuromuscular Blockade / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents; D011446:Prospective Studies; D000077123:Rocuronium; D064171:Superficial Back Muscles / Q000187:drug effects* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium