title: Analysis of the therapeutic evolution in the management of airway infantile hemangioma.
abstract: OBJECTIVE
  To analyze the evolution in the management of airway infantile hemangioma (AIH) and to report the results from 3 pediatric tertiary care institutions.
  
  
  METHODS
  A retrospective study of patients with diagnosis of AIH and treated in 3 pediatric tertiary care institutions from 1996 to 2014 was performed.
  
  
  RESULTS
  Twenty-three patients with diagnosis of AIH were identified. Mean age at diagnosis was 6 mo (range, 1-27). Single therapy was indicated in 16 patients and 7 patients received combined therapy. Two therapeutic groups were identified: Group A included 14 patients who were treated with steroids, interferon, laser therapy and/or surgery; group B included 9 patients treated with oral propranolol. In group A, oral corticosteroids were used in 9 patients with a good response in 3 cases (no requiring other therapeutic option), the other patients required additional treatment options. Cushing syndrome was observed in 3 patients. One patient died of a fulminant sepsis. Open surgical excision and endoscopic therapy were performed in 11 patients (in 5 of them as a single treatment) with a response rate of 54.5%. Stridor persisted in 2 cases, and one patient died during the clinical course of bronchial aspiration. In group B, oral propranolol was used in 9 patients (in 8 of them as a single treatment) with a response rate of 100%, with an mean treatment duration of 7 mo (range, 5-10); complications were not observed.
  
  
  CONCLUSIONS
  Our experience and the medical literature support the use of propranolol as a first line of treatment in AIH.
authors: Grecia V Vivas-Colmenares, Israel Fernandez-Pineda, Miguel Angel Fernandez-Hurtado, Jose Antonio Matute de Cardenas, Department of Pediatric Surgery, Virgen del Rocio Children's Hospital, 41013 Sevilla, Spain.
authors: Grecia V
authors: GV
authors: Vivas-Colmenares
authors: Grecia V Vivas-Colmenares, Israel Fernandez-Pineda, Miguel Angel Fernandez-Hurtado, Jose Antonio Matute de Cardenas, Department of Pediatric Surgery, Virgen del Rocio Children's Hospital, 41013 Sevilla, Spain.
authors: Israel
authors: I
authors: Fernandez-Pineda
authors: Grecia V Vivas-Colmenares, Israel Fernandez-Pineda, Miguel Angel Fernandez-Hurtado, Jose Antonio Matute de Cardenas, Department of Pediatric Surgery, Virgen del Rocio Children's Hospital, 41013 Sevilla, Spain.
authors: Juan Carlos
authors: JC
authors: Lopez-Gutierrez
authors: Grecia V Vivas-Colmenares, Israel Fernandez-Pineda, Miguel Angel Fernandez-Hurtado, Jose Antonio Matute de Cardenas, Department of Pediatric Surgery, Virgen del Rocio Children's Hospital, 41013 Sevilla, Spain.
authors: Miguel Angel
authors: MA
authors: Fernandez-Hurtado
authors: Grecia V Vivas-Colmenares, Israel Fernandez-Pineda, Miguel Angel Fernandez-Hurtado, Jose Antonio Matute de Cardenas, Department of Pediatric Surgery, Virgen del Rocio Children's Hospital, 41013 Sevilla, Spain.
authors: Maria Antonia
authors: MA
authors: Garcia-Casillas
authors: Grecia V Vivas-Colmenares, Israel Fernandez-Pineda, Miguel Angel Fernandez-Hurtado, Jose Antonio Matute de Cardenas, Department of Pediatric Surgery, Virgen del Rocio Children's Hospital, 41013 Sevilla, Spain.
authors: Jose Antonio
authors: JA
authors: Matute de Cardenas
keywords: Airway; Fibrobronchoscopy; Infantile hemangioma; Propranolol; Surgery