title: Regulation of Arabidopsis MAPKKK18 by ABI1 and SnRK2, components of the ABA signaling pathway.
abstract: The plant hormone abscisic acid (ABA), a key regulator in many crucial developmental and physiological processes, recruits diverse components into precisely regulated signaling network. We recently discovered that MAPKKK18, an ABA-activated kinase, is regulated by the protein phosphatase type 2C (PP2C) ABI1 and the kinase SnRK2.6, both components of the ABA core signaling pathway. ABI1 acts to inhibit MAPKKK18 kinase activity, but also affects MAPKKK18 protein turnover via the ubiquitin-proteasome pathway. SnRK2.6 kinase also seems to be important for the regulation of MAPKKK18 function. In this review we summarize the mechanisms that are exclusively involved in MAPKKK18 kinase regulation and that ensure specificity in its activation.
authors: a Department of Biotechnology , Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznan , Umultowska , Poznan , Poland.
authors: Małgorzata
authors: M
authors: Tajdel
authors: a Department of Biotechnology , Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznan , Umultowska , Poznan , Poland.
authors: Filip
authors: F
authors: Mituła
authors: a Department of Biotechnology , Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznan , Umultowska , Poznan , Poland.
authors: Agnieszka
authors: A
authors: Ludwików
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism*; D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; C492978:SnRK2 protein, Arabidopsis; D000040:Abscisic Acid; D017346:Protein Serine-Threonine Kinases; D020930:MAP Kinase Kinase Kinases; C000598433:MAPKKK18 protein, Arabidopsis; C087434:ABI1 protein, Arabidopsis; D010749:Phosphoprotein Phosphatases
keywords: ABA signaling; ABI1; Arabidopsis thaliana; MAP kinase cascade; MAPKKK18; PP2C; SnRK2; UPS