title: [Infertility and breast cancer: Is there a link? Updated review of the literature and meta-analysis].
abstract: The objective of this review was to assess the level of risk of breast cancer of patients consulting for infertility.
  
  
  METHODS
  Studies of cohorts and case-control were extracted from the Pubmed database from January 2000 until May 2015 through the following keywords: "infertility"; "endometriosis"; "polycystic ovary syndrome"; "breast cancer", "cancer risk". Eleven publications were finally selected after exclusion of publications dealing with infertility after breast cancer. Our meta-analysis, involving 10 of these publications, was performed using Review Manager software, Cochrane Collaboration, 2014. The results were calculated by etiology of infertility, polycystic ovary syndrome (PCOS) and endometriosis, as well as globally.
  
  
  RESULTS
  The analysis of these published epidemiological studies confirms that infertility is not a breast cancer risk factor, but the results are contradictory. Three studies have shown a significantly increased risk of breast cancer in a population of infertile women, while 7 others have not found this risk. These contradictions are due to the heterogeneity of the studies, the included populations, the follow-up periods and confounding factors. Our meta-analysis of the selected studies has not identified a significant association between infertility and breast cancer risk (1.05; 95% CI [0.96-1.16]). A subgroup analysis on endometriosis and PCOS showed no significant association either, with an OR of 1.02 (95% CI [0.87-1.19]) and 1.19 (95% CI [0.93-1.51]), respectively.
  
  
  CONCLUSIONS
  Infertility is not an identified risk factor for breast cancer. A message reassuring about a possible risk of infertility-related breast cancer should be given to these patients. Infertility is therefore not an indication of increased breast surveillance.
authors: Unité de sénologie, hôpital de Hautepierre, CHRU de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France. Electronic address: Victor.gab974@gmail.com.
authors: V
authors: V
authors: Gabriele
authors: Unité de sénologie, hôpital de Hautepierre, CHRU de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France.
authors: E
authors: E
authors: Gapp-Born
authors: Centre médico-chirurgical et obstétrical (CMCO), 19, rue Louis-Pasteur, 67303 Schiltigheim, France.
authors: J
authors: J
authors: Ohl
authors: Unité de sénologie, hôpital de Hautepierre, CHRU de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France.
authors: C
authors: C
authors: Akladios
authors: Unité de sénologie, hôpital de Hautepierre, CHRU de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France.
authors: C
authors: C
authors: Mathelin
mesh_terms: D001943:Breast Neoplasms; D004715:Endometriosis; D005260:Female; D006801:Humans; D007247:Infertility, Female; D011085:Polycystic Ovary Syndrome; D012307:Risk Factors
keywords: Breast cancer; Cancer du sein; Endometriosis; Endométriose; Infertility; Infertilité; Meta-analysis; Méta-analyse; Polycystic ovary syndrome; Syndrome des ovaires polykystiques