title: Cardiopulmonary fitness, adiponectin, chemerin associated fasting insulin level in colorectal cancer patients.
abstract: Since circulating level of insulin is associated with colorectal cancer prognosis, it is important to identify factors contributing to fasting insulin level in colorectal cancer patients. The purpose of the current study is to investigate the association of physical fitness, adiponectin, and chemerin levels with circulating level of insulin in colorectal cancer patients.
  
  
  
  A total of 123 stage II-III colorectal cancer patients who completed standard cancer treatment were recruited. Anthropometric characteristics, fitness measurements, fasting insulin level, homeostasis model assessment of insulin resistance, lipid profiles, and adiponectin and chemerin levels were analyzed.
  
  
  
  Cardiopulmonary fitness level inversely associated with fasting insulin levels (the least fit (1st tertile): 8.11 ± 0.64, moderately fit (2nd tertile): 6.02 ± 0.63, and highly fit (3rd tertile): 5.58 ± 0.66 μU/ml, unfit vs. moderately fit, p < 0.01; unfit vs. highly fit, p < 0.05) after adjustment for gender, age, stage, and BMI. In addition, fasting adiponectin and chemerin levels were associated with fasting insulin levels after adjustment for gender, age, stage, and BMI. In our combined analyses, participants with high adiponectin and low chemerin levels showed significantly lower fasting insulin levels (4.92 ± 0.75 vs. 8.07 ± 0.80 μU/ml, p < 0.01) compared with participants with low adiponectin and high chemerin levels. Multiple linear regression analysis confirmed that cardiopulmonary fitness and adiponectin levels (β = -0.299, p = 0.002; β = -0.201, p = 0.033) were independently associated with fasting insulin level.
  
  
  
  Our results suggest that physical fitness and adiponectin and chemerin levels may contribute to circulating levels of insulin. These results suggest that exercise may influence the prognosis of colorectal cancer patients by influencing physical fitness level, circulating levels of adiponectin and chemerin.
authors: Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea.
authors: Ki-Yong
authors: KY
authors: Ahn
authors: Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea.
authors: Mi Kyung
authors: MK
authors: Lee
authors: Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea.
authors: Dong-Il
authors: DI
authors: Kim
authors: Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea.
authors: Jihye
authors: J
authors: Park
authors: Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea.
authors: Jihee
authors: J
authors: Min
authors: Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea.
authors: Hyuk In
authors: H
authors: Yang
authors: Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea.
authors: Junga
authors: J
authors: Lee
authors: Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea.
authors: Minsuk
authors: M
authors: Oh
authors: Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, Republic of Korea.
authors: Joongbae
authors: J
authors: An
authors: Department of Family Medicine, Yonsei University, College of Medicine, Seoul, Republic of Korea.
authors: Ji-Won
authors: JW
authors: Lee
authors: Department of Clinical Nursing Science, Yonsei University, College of Nursing, Nursing Policy Research Institute, Biobehavioral Research Center, Seoul, Republic of Korea.
authors: Sang Hui
authors: SH
authors: Chu
authors: Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
authors: Jeffrey A
authors: JA
authors: Meyerhardt
authors: Department of Surgery, Yonsei University College of Medicine, 250 Seongsan-ro, Seodaemun-gu, Seoul, 120-752, South Korea. namkyuk@yuhs.ac.|Department of Sport and Leisure Studies, Exercise Medicine Center for Diabetes and Cancer Patients, Yonsei University, Shinchon-dong, Seodaemun-gu, Seoul, 120-749, South Korea. namkyuk@yuhs.ac.
authors: Nam-Kyu
authors: NK
authors: Kim
authors: Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea. jjeon@yonsei.ac.kr.|Department of Sport and Leisure Studies, Exercise Medicine Center for Diabetes and Cancer Patients, Yonsei University, Shinchon-dong, Seodaemun-gu, Seoul, 120-749, South Korea. jjeon@yonsei.ac.kr.
authors: Justin Y
authors: JY
authors: Jeon
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D020740:Chimerin Proteins / Q000378:metabolism*; D015179:Colorectal Neoplasms; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D052242:Adiponectin; D020740:Chimerin Proteins; D007328:Insulin
keywords: Adiponectin; Chemerin; Colorectal cancer; Fitness; Insulin