title: Nitric oxide generating/releasing materials.
abstract: Harnessing the impressive therapeutic potential of nitric oxide (NO) remains an ongoing challenge. This paper describes several of the current strategies both with respect to the underlying chemistry and physics and to the applications where they have shown promise. Included in this overview are molecular systems such as NONOates that release NO through chemical reactions and delivery vehicles such as nanoparticles that can generate, store, transport and deliver NO and related bioactive forms of NO such as nitrosothiols. Although there has been much positive movement, it is clear that we are only at the early stages of knowing how to precisely produce, transport and deliver to targeted sites therapeutic levels of NO and related molecules.
authors: Department of Physiology & Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
authors: Hongying
authors: H
authors: Liang
authors: Department of Physiology & Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
authors: Parimala
authors: P
authors: Nacharaju
authors: Department of Dermatology, George Washington School of Medicine & Health Sciences, NW, Washington, DC 20037, USA.
authors: Adam
authors: A
authors: Friedman
authors: Department of Physiology & Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
authors: Joel M
authors: JM
authors: Friedman
keywords: NO; NONOates; liposomes; nanoparticles; nitrosothiols