title: [The Protective Effect of B7-H4 on Concanavalin A Induced Hepatic Injury in Mice].
abstract: OBJECTIVE
  To explore the protective effect and its mechanism of B7-H4 on the immuno hepatic injury.
  
  
  METHODS
  The immuno hepatic injury was induced by Concanavalin A (Con A). Sixty KM mice were randomly divided into 4 groups with 15 mice in each group: Group A (saline), Group B (pcDNA3.1-mB7-H4-Fc), Group C (pcDNA3.1), Group D (Con A). One day before the injection of Con A (25 mg/kg), the mice in Group B and Group C received the injection of 100 pg pcDNA3.1-mB7-H4-Fc and 100 microg pcDNA3.1 respectively. The blood samples were collected at 12 h, 24 h and 48 h after Con A injection, the levels of ALT, AST, IL-4 and IFN-gamma were measured. Five mice in each group were sacrificed at the above 3 time points, the liver tissue were harvested for histopathological detection.
  
  
  RESULTS
  After Con A injection, the level of ALT in Group B, C, and D were higher than that in Group A. The level of ALT in Group B was lower than that in Group C and D. The significant difference was found between Group B and Group C. The hepatic injury of Group B was less serious than that of Group C and D.
  
  
  CONCLUSIONS
  B7-H4 may have protection on the immune injury of liver induced by Con A.
authors: Huan
authors: H
authors: Xiao
authors: Wei-min
authors: WM
authors: Pan
authors: Chao-qun
authors: CQ
authors: Wang
authors: Hong-yan
authors: HY
authors: Chen
authors: Jun-fa
authors: JF
authors: Xu
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000276:immunology; D003208:Concanavalin A / Q000009:adverse effects*; D051379:Mice; D020011:Protective Agents / Q000494:pharmacology; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1 / Q000494:pharmacology*
chemical_list: D020011:Protective Agents; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1; D003208:Concanavalin A