title: [Small animal image-guided radiotherapy: A new era for preclinical studies].
abstract: Preclinical external beam radiotherapy irradiations used to be delivered with a static broad beam. To promote the transfer from animal to man, the preclinical treatment techniques dedicated to the animal have been optimized to be similar to those delivered to patients in clinical practice. In this context, preclinical irradiators have been developed. Due to the small sizes of the animals, and the irradiation beams, the scaling to the small animal dimensions involves specific problems. Reducing the size and energy of the irradiation beams require very high technical performance, especially for the mechanical stability of the irradiator and the spatial resolution of the imaging system. In addition, the determination of the reference absorbed dose rate must be conducted with a specific methodology and suitable detectors. To date, three systems are used for preclinical studies in France. The aim of this article is to present these new irradiators dedicated to small animals from a physicist point of view, including the commissioning and the quality control.
authors: Inserm U892 CRCNA, 8, quai Moncousu, BP 70721, 44007 Nantes cedex 1, France; Institut de cancérologie de l'Ouest René-Gauducheau, boulevard Jacques-Monod, 44805 Saint-Herblain, France. Electronic address: gregory.delpon@ico.unicancer.fr.
authors: G
authors: G
authors: Delpon
authors: Grand laboratoire national d'ions lourds (Ganil), CEA/DSM, boulevard Henri-Becquerel, BP 55027, 14076 Caen cedex 5, France; Ganil, CNRS/IN2P3, boulevard Henri-Becquerel, BP 55027, 14076 Caen cedex 5, France.
authors: A-M
authors: AM
authors: Frelin-Labalme
authors: Département de recherche translationnelle, institut Curie, 15, rue Georges-Clémenceau, 91898 Orsay cedex, France.
authors: S
authors: S
authors: Heinrich
authors: GIP Cyceron, boulevard Henri-Becquerel, BP 5229, 14074 Caen cedex 5, France.
authors: V
authors: V
authors: Beaudouin
authors: Inserm U892 CRCNA, 8, quai Moncousu, BP 70721, 44007 Nantes cedex 1, France.
authors: C
authors: C
authors: Noblet
authors: Institut de cancérologie de l'Ouest René-Gauducheau, boulevard Jacques-Monod, 44805 Saint-Herblain, France.
authors: M
authors: M
authors: Begue
authors: Grand laboratoire national d'ions lourds (Ganil), CEA/DSM, boulevard Henri-Becquerel, BP 55027, 14076 Caen cedex 5, France; Ganil, CNRS/IN2P3, boulevard Henri-Becquerel, BP 55027, 14076 Caen cedex 5, France.
authors: C
authors: C
authors: Le Deroff
authors: Département de recherche translationnelle, institut Curie, 15, rue Georges-Clémenceau, 91898 Orsay cedex, France.
authors: F
authors: F
authors: Pouzoulet
authors: Inserm U892 CRCNA, 8, quai Moncousu, BP 70721, 44007 Nantes cedex 1, France; Institut de cancérologie de l'Ouest René-Gauducheau, boulevard Jacques-Monod, 44805 Saint-Herblain, France.
authors: S
authors: S
authors: Chiavassa
mesh_terms: D000818:Animals; D011786:Quality Control; D011879:Radiotherapy Dosage; D061089:Radiotherapy, Image-Guided / Q000295:instrumentation* / Q000379:methods
keywords: Irradiateur; Irradiator; Mouse; Radiobiologie; Radiobiology; Radiotherapy; Radiothérapie; Souris