title: Successful treatment of severe kerion Celsi in an immunocompromised girl with evacuation of pus, terbinafine and short course glucocorticosteroids.
abstract: A 6-year-old girl with a 2-year history of idiopathic thrombocytopenic purpura complained of a 4-week history of scalp desquamation together with small pustules. During the recent 10 days, she complained of high fever with multiple abscesses formation with no response to intravenous antibiotics. She received varied doses of oral prednisone therapy for 2 years. Microscopy showed endothrix infection. We prescribed terbinafine 125 mg/d and prednisone 10 mg/d. After 1 week, she returned to our office with severe ache and persistent high fever. She refused any topical drugs because of pain. Manual pressure to remove pus from sinuses and infected scale under general anesthesia was done and about 100 ml pus was discharged from kerion lesions. Prednisone (1 mg/kg/d) was started and fever disappeared on the same day. Prednisone was tapered to withdraw in 10 days. A total of a 3-month course of oral terbinafine (125 mg/d) resulted in mycological clearance. Hair regrowth was satisfactory 8 months later.
authors: Department of Dermatology, Affiliated Third Hospital of Hangzhou, Anhui Medical University, West Lake Rd 38, Hangzhou, China.
authors: Z H
authors: ZH
authors: Liu
authors: Department of Dermatology, Affiliated Third Hospital of Hangzhou, Anhui Medical University, West Lake Rd 38, Hangzhou, China.
authors: Y
authors: Y
authors: Zhang
authors: Department of Dermatology, Affiliated Third Hospital of Hangzhou, Anhui Medical University, West Lake Rd 38, Hangzhou, China.
authors: J
authors: J
authors: Zhu
authors: Department of Dermatology, Affiliated Third Hospital of Hangzhou, Anhui Medical University, West Lake Rd 38, Hangzhou, China.
authors: Y Q
authors: YQ
authors: Dai
authors: Department of Dermatology, Affiliated Third Hospital of Hangzhou, Anhui Medical University, West Lake Rd 38, Hangzhou, China. Electronic address: shenhongsh@yahoo.com.
authors: H
authors: H
authors: Shen
mesh_terms: D000038:Abscess / Q000150:complications / Q000628:therapy; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D004322:Drainage; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006197:Hair / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D009281:Naphthalenes / Q000627:therapeutic use*; D011241:Prednisone / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000276:immunology; D013492:Suppuration / Q000382:microbiology / Q000628:therapy; D000077291:Terbinafine; D014006:Tinea Capitis / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D014249:Trichophyton / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D005938:Glucocorticoids; D009281:Naphthalenes; D000077291:Terbinafine; D011241:Prednisone
keywords: Discharging pus; Kerion Celsi; Kerion de Celse; Trichophyton mentagrophytes; Évacuation de pus