title: Antithrombotic Therapy After Peripheral Vascular Intervention.
abstract: Cardioprotective medications and risk-factor modification are the hallmarks of treatment for all patients with peripheral artery disease (PAD). If symptoms are life-limiting and/or do not respond to conservative treatment, endovascular or surgical revascularization can be considered especially for patients with critical limb ischemia or acute limb ischemia. The rates of peripheral vascular intervention (PVI) have risen dramatically over the past few decades and much of this care have shifted from inpatient hospital settings to outpatient settings and office-based clinics. While PVI rates have surged and technology advancements have dramatically changed the face of PVI, the data behind optimal antithrombotic therapy following PVI is scant. Currently in the USA, most patients are treated with indefinite aspirin therapy and a variable duration of clopidogrel (or other P2Y12 inhibitor)-typically 1 month, 3 months, or indefinite therapy. More observational analyses and randomized clinical trials evaluating clinically relevant outcomes such as cardiovascular morbidity/mortality and the risk of bleeding are needed to guide the optimal role and duration of antithrombotic therapy post-PVI.
authors: Department of Medicine, Duke University Medical Center, Durham, NC, USA.
authors: Peter
authors: P
authors: Hu
authors: Department of Medicine, Duke University Medical Center, Durham, NC, USA. schuyler.jones@dm.duke.edu.|Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA. schuyler.jones@dm.duke.edu.
authors: Schuyler
authors: S
authors: Jones
mesh_terms: D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000379:methods; D001241:Aspirin / Q000627:therapeutic use; D017073:Atherectomy / Q000009:adverse effects / Q000379:methods; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D058729:Peripheral Arterial Disease / Q000628:therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
keywords: Antithrombotic therapy; Aspirin; Clopidogrel; Peripheral artery disease; Peripheral vascular intervention