title: Gray matter correlates of dopaminergic degeneration in Parkinson's disease: A hybrid PET/MR study using (18) F-FP-CIT.
abstract: Dopaminergic degeneration is a hallmark of Parkinson's disease (PD), which causes various symptoms affected by corticostriatal circuits. So far, the relationship between cortical changes and dopamine loss in the striatum is unclear. Here, we evaluate the gray matter (GM) changes in accordance with striatal dopaminergic degeneration in PD using hybrid PET/MR. Sixteen patients with idiopathic PD underwent (18) F-FP-CIT PET/MR. To measure dopaminergic degeneration in PD, binding ratio (BR) of dopamine transporter in striatum was evaluated by (18) F-FP-CIT. Voxel-based morphometry (VBM) was used to evaluate GM density. We obtained voxelwise correlation maps of GM density according to the striatal BR. Voxel-by-voxel correlation between BR maps and GM density maps was done to evaluate region-specific correlation of striatal dopaminergic degeneration. There was a trend of positive correlation between striatal BR and GM density in the cerebellum, parahippocampal gyri, and frontal cortex. A trend of negative correlation between striatal BR and GM density in the medial occipital cortex was found. Voxel-by-voxel correlation revealed that the positive correlation was mainly dependent on anterior striatal BR, while posterior striatal BR mostly showed negative correlation with GM density in occipital and temporal cortices. Decreased GM density related to anterior striatal dopaminergic degeneration might demonstrate degeneration of dopaminergic nonmotor circuits. Furthermore, the negative correlation could be related to the motor circuits of posterior striatum. Our integrated PET/MR study suggests that the widespread structural progressive changes in PD could denote the cortical functional correlates of the degeneration of striatal dopaminergic circuits. Hum Brain Mapp 37:1710-1721, 2016. © 2016 Wiley Periodicals, Inc.
authors: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.
authors: Hongyoon
authors: H
authors: Choi
authors: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.|Cancer Research Institute, Seoul National University, Seoul, Korea.
authors: Gi Jeong
authors: GJ
authors: Cheon
authors: Department of Neurology and Movement Disorder Center, Seoul National University Hospital, Seoul, Korea.
authors: Han-Joon
authors: HJ
authors: Kim
authors: Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.|Center for Nanoparticle Research, Institute for Basic Science, and School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea.
authors: Seung Hong
authors: SH
authors: Choi
authors: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.|Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
authors: Yong-Il
authors: YI
authors: Kim
authors: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.|Cancer Research Institute, Seoul National University, Seoul, Korea.
authors: Keon Wook
authors: KW
authors: Kang
authors: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.|Cancer Research Institute, Seoul National University, Seoul, Korea.
authors: June-Key
authors: JK
authors: Chung
authors: Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.|Department of Radiological Sciences, University of California, Irvine, CA.
authors: E Edmund
authors: EE
authors: Kim
authors: Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.|Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
authors: Dong Soo
authors: DS
authors: Lee
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D010300:Parkinson Disease / Q000150:complications*; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D014326:Tropanes / Q000493:pharmacokinetics
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D004298:Dopamine
keywords: 18F-FP-CIT; PET/MR; Parkinson's disease; basal ganglia; voxel-based morphometry