title: Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer.
abstract: The aim of the present study was to establish whether intensity-modulated radiotherapy (IMRT) with concurrent gemcitabine and S-1 is a feasible treatment option for patients with locally advanced pancreatic ductal adenocarcinoma. Patients with pancreatic ductal adenocarcinoma were prospectively enrolled. An IMRT dose of 50.4 Gy in 28 fractions with concurrent gemcitabine at a dose of 600 mg/m2and S-1 at a dose of 60 mg were administrated. Adverse events and associated dosimetric factors were assessed. Between February 2012 and January 2014, 17 patients with borderline resectable and 4 with unresectable pancreatic cancer were enrolled. None of the patients experienced grade 3 or worse nausea and vomiting. The planning target volume (≥200 vs. <200 ml) was a statistically significant predictive factor for neutrocytopenia (≥500 vs. 500/µl, P=0.02). Concurrent IMRT with gemcitabine and S-1 for patients with locally advanced pancreatic cancer is feasible, with tolerable hematological toxicities and low gastrointestinal toxicities.
authors: Department of Radiology, Tokyo Medical University, Shinjyuku, Tokyo 160-0023, Japan.
authors: Norifumi
authors: N
authors: Kennoki
authors: Department of Radiology, Tokyo Medical University, Shinjyuku, Tokyo 160-0023, Japan.
authors: Hidetsugu
authors: H
authors: Nakayama
authors: Third Department of Surgery, Tokyo Medical University, Shinjyuku, Tokyo 160-0023, Japan.
authors: Yuichi
authors: Y
authors: Nagakawa
authors: Third Department of Surgery, Tokyo Medical University, Shinjyuku, Tokyo 160-0023, Japan.
authors: Yuichi
authors: Y
authors: Hosokawa
authors: Department of Radiology, Tokyo Medical University, Shinjyuku, Tokyo 160-0023, Japan.
authors: Tomohiro
authors: T
authors: Itonaga
authors: Department of Radiology, Tokyo Medical University, Shinjyuku, Tokyo 160-0023, Japan.
authors: Y U
authors: YU
authors: Tajima
authors: Department of Radiology, Tokyo Medical University, Shinjyuku, Tokyo 160-0023, Japan.
authors: Sachica
authors: S
authors: Shiraishi
authors: Department of Radiology, Tokyo Medical University, Shinjyuku, Tokyo 160-0023, Japan.
authors: Ryuji
authors: R
authors: Mikami
authors: Third Department of Surgery, Tokyo Medical University, Shinjyuku, Tokyo 160-0023, Japan.
authors: Akihiko
authors: A
authors: Tsuchida
authors: Department of Radiology, Tokyo Medical University, Shinjyuku, Tokyo 160-0023, Japan.
authors: Koichi
authors: K
authors: Tokuuye
keywords: chemoradiotherapy; intensity-modulated radiotherapy; pancreatic cancer; preoperative