title: Tocilizumab for treating juvenile idiopathic arthritis.
abstract: BACKGROUND
  Based on the known relevance of IL-6 in juvenile idiopathic arthritis (JIA) pathophysiology, tocilizumab has been investigated and approved for use in the treatment of systemic and polyarticular JIA. Tocilizumab is a humanized monoclonal antibody that inhibits signaling through both membrane bound and soluble IL-6R.
  
  
  METHODS
  The purpose of this article is to summarize the available clinical data on the efficacy and safety of tocilizumab in JIA and to provide our opinion on the place of tocilizumab in current treatment regimens. A literature search for all relevant clinical trials and studies with regards to tocilizumab, JIA and IL-6 was performed through PubMed, in addition to a review of recent conference abstracts.
  
  
  CONCLUSIONS
  Tocilizumab has an important and evolving role in controlling disease activity in patients with JIA. It has proven useful even in patients whose JIA has previously been refractory to other biologic disease modifying anti-rheumatic drugs (DMARDs) and also appears quite effective as monotherapy. Tocilizumab is relatively well tolerated amongst JIA patients, with systemic JIA patients experiencing more serious adverse events overall.
authors: a Division of Rheumatology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center , University of Cincinnati College of Medicine , Cincinnati , OH , USA.
authors: Jessica L
authors: JL
authors: Turnier
authors: a Division of Rheumatology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center , University of Cincinnati College of Medicine , Cincinnati , OH , USA.
authors: Hermine I
authors: HI
authors: Brunner
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D006801:Humans; D019947:Receptors, Interleukin-6 / Q000037:antagonists & inhibitors; D015398:Signal Transduction
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D019947:Receptors, Interleukin-6; C502936:tocilizumab
keywords: Interleukin-6; Juvenile Idiopathic Arthritis; tocilizumab