title: Conventional and New Antiepileptic Drugs on Vitamin D and Bone Health: What We Know to Date?
abstract: The treatment with antiepileptic drugs (AEDs), in particular conventional drugs, induces an increased risk of fractures in women and in epileptic patients in treatment with AEDs for more than 12 years. A supplementation with calcium and vitamin D is suggested in patients chronically treated with some AEDs and there are recommendations to do so. The lack of significant conclusive evidence about the effects of conventional and newer AEDs on bone metabolism needs for more clinical studies in order to perform an appropriate use of calcium and vitamin D supplementation in young and ederly epileptic patients.
authors: Department of Neurology, Annunziata Hospital, Via F. Migliori, 1 - 87100 Cosenza, Italy. anto.siniscalchi@libero.it.
authors: Antonio
authors: A
authors: Siniscalchi
authors: Giovambattista
authors: G
authors: De Arro
authors: Andzelika
authors: A
authors: Michniewicz
authors: Luca
authors: L
authors: Gallelli
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D019587:Dietary Supplements / Q000009:adverse effects; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D050723:Fractures, Bone / Q000097:blood / Q000139:chemically induced; D006801:Humans; D014807:Vitamin D / Q000097:blood*
chemical_list: D000927:Anticonvulsants; D014807:Vitamin D