title: Cell-based strategies for vascular regeneration.
abstract: Vascular regeneration is known to play an essential role in the repair of injured tissues mainly through accelerating the repair of vascular injury caused by vascular diseases, as well as the recovery of ischemic tissues. However, the clinical vascular regeneration is still challenging. Cell-based therapy is thought to be a promising strategy for vascular regeneration, since various cells have been identified to exert important influences on the process of vascular regeneration such as the enhanced endothelium formation on the surface of vascular grafts, and the induction of vessel-like network formation in the ischemic tissues. Here are a vast number of diverse cell-based strategies that have been extensively studied in vascular regeneration. These strategies can be further classified into three main categories, including cell transplantation, construction of tissue-engineered grafts, and surface modification of scaffolds. Cells used in these strategies mainly refer to terminally differentiated vascular cells, pluripotent stem cells, multipotent stem cells, and unipotent stem cells. The aim of this review is to summarize the reported research advances on the application of various cells for vascular regeneration, yielding insights into future clinical treatment for injured tissue/organ.
authors: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, People's Republic of China.
authors: Tongqiang
authors: T
authors: Zou
authors: Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, California, 90095.
authors: Jiabing
authors: J
authors: Fan
authors: Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, California, 90095.
authors: Armita
authors: A
authors: Fartash
authors: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, People's Republic of China.
authors: Haifeng
authors: H
authors: Liu
authors: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, People's Republic of China.|National Research Center for Rehabilitation Technical Aids, Beijing, 100176, People's Republic of China.
authors: Yubo
authors: Y
authors: Fan
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D001808:Blood Vessels / Q000166:cytology* / Q000293:injuries / Q000502:physiology; D002454:Cell Differentiation; D006801:Humans; D018919:Neovascularization, Physiologic; D033581:Stem Cell Transplantation / Q000379:methods; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*
keywords: cell-based strategies; stem cells; vascular regeneration