title: Glutamate E15 and E171 are Hotspots in p60TRP-Related Cancer.
abstract: RAS protein is a small G protein linked to multiple G protein-coupled receptor (GPCR) signaling cascades and is responsible for various types of cancer, but to this day, Ras is considered "undruggable." Multiple alternative regulators of G protein signaling (RGS) pathways have become the focus of ongoing efforts to identify new cancer therapeutics. We analyzed human cancer genome datasets and describe p60TRP, a recently identified GPCR-associated sorting protein (GPRASP), and its role in various types of cancer. We found that some regions of p60TRP were more prone to specific mutations, with two hotspots for mutations at E15 and E171.
authors: a Department of Information Systems , College of Engineering, Hanyang University , Seoul , Republic of Korea.
authors: Arne
authors: A
authors: Kutzner
authors: b Graduate School of Biomedical Science and Engineering, Hanyang University , Seoul , Republic of Korea.
authors: Klaus
authors: K
authors: Heese
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D019295:Computational Biology; D004252:DNA Mutational Analysis; D030541:Databases, Genetic; D020022:Genetic Predisposition to Disease; D018698:Glutamic Acid; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D010641:Phenotype; D060066:Protein Interaction Maps; D015398:Signal Transduction; D043562:Receptors, G-Protein-Coupled
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D014408:Biomarkers, Tumor; D018698:Glutamic Acid; C496842:GPRASP3 protein, human; D043562:Receptors, G-Protein-Coupled
keywords: BHLHB9; Cancer; GASP; GPRASP; Ran; Ras; p60TRP