title: A longitudinal study of the association between the GNB3 C825T polymorphism and metabolic disturbance in bipolar II patients treated with valproate.
abstract: This longitudinal study aimed to investigate the associations between the polymorphisms of guanine nucleotide-binding protein subunit β-3 (GNB3) C825T and metabolic disturbance in bipolar II disorder (BP-II) patients being treated with valproate (VPA). A 100 BP-II patients received a 12-week course of VPA treatment, and their body weight and metabolic indices were measured. At baseline, the GNB3 C825T polymorphisms were associated with the triglyceride level (P=0.032) in BP-II patients. During the VPA treatment course, the polymorphisms were not only associated with body mass index (BMI) and waist circumference (P-values=0.009 and 0.001, respectively), but also with total cholesterol, triglyceride, low-density lipoprotein and leptin levels (P-values=0.004, 0.002, 0.031 and 0.015, respectively). Patients with the TT genotype had a lower BMI, smaller waist circumference, and lower levels of lipids and leptin than those with the CT or CC genotypes undergoing the VPA treatment course.
authors: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Addiction Research Center, National Cheng Kung University, Tainan, Taiwan.
authors: P S
authors: PS
authors: Chen
authors: Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors: H H
authors: HH
authors: Chang
authors: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors: C-C
authors: CC
authors: Huang
authors: Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors: C C
authors: CC
authors: Lee
authors: Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors: S-Y
authors: SY
authors: Lee
authors: Department of Neurology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: S-L
authors: SL
authors: Chen
authors: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors: S-Y
authors: SY
authors: Huang
authors: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Addiction Research Center, National Cheng Kung University, Tainan, Taiwan.|Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan.|Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors: Y K
authors: YK
authors: Yang
authors: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Addiction Research Center, National Cheng Kung University, Tainan, Taiwan.
authors: R-B
authors: RB
authors: Lu
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D015992:Body Mass Index; D016022:Case-Control Studies; D050171:Dyslipidemias / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics*; D000071184:Pharmacogenomic Variants; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014635:Valproic Acid / Q000009:adverse effects*; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D018692:Antimanic Agents; D015415:Biomarkers; C000595803:GNB3 protein, human; D020738:Leptin; D008055:Lipids; D014635:Valproic Acid; D020962:Heterotrimeric GTP-Binding Proteins