title: Clinical applications of circulating tumor DNA and circulating tumor cells in pancreatic cancer.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is the most frequent pancreatic cancer type and is characterized by a dismal prognosis due to late diagnosis, local tumor invasion, frequent distant metastases and poor sensitivity to current therapy. In this context, circulating tumor cells and circulating tumor DNA constitute easily accessible blood-borne tumor biomarkers that may prove their clinical interest for screening, early diagnosis and metastatic risk assessment of PDAC. Moreover these markers represent a tool to assess PDAC mutational landscape. In this review, together with key biological findings, we summarize the clinical results obtained using "liquid biopsies" at the different stages of the disease, for early and metastatic diagnosis as well as monitoring during therapy.
authors: Institut Curie, PSL Research University, SiRIC, Laboratory of Circulating Tumor Biomarkers, Paris, France; San Gerardo Hospital, Department of Medical Oncology, Monza, Italy.
authors: Francesca
authors: F
authors: Riva
authors: Bogomolets National Medical University, Department of General Surgery No. 1, Kiev, Ukraine.
authors: Oleksii I
authors: OI
authors: Dronov
authors: Bogomolets National Medical University, Department of General Surgery No. 1, Kiev, Ukraine.
authors: Dmytro I
authors: DI
authors: Khomenko
authors: Hopital Tenon, Pierre and Marie Curie Paris VI University, Department of Radiation Oncology, Paris, France.
authors: Florence
authors: F
authors: Huguet
authors: Institut Mutualiste Montsouris, Department of Medical Oncology, Paris, France.
authors: Christophe
authors: C
authors: Louvet
authors: Institut Curie, PSL Research University, Department of Surgery, Paris, France.
authors: Pascale
authors: P
authors: Mariani
authors: Institut Curie, PSL Research University, INSERM U830, Paris, France.
authors: Marc-Henri
authors: MH
authors: Stern
authors: Institut Curie, PSL Research University, INSERM U932, Paris, France.
authors: Olivier
authors: O
authors: Lantz
authors: Institut Curie, PSL Research University, SiRIC, Laboratory of Circulating Tumor Biomarkers, Paris, France.
authors: Charlotte
authors: C
authors: Proudhon
authors: Institut Curie, PSL Research University, SiRIC, Laboratory of Circulating Tumor Biomarkers, Paris, France; Institut Curie, PSL Research University, Department of Medical Oncology, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors: Jean-Yves
authors: JY
authors: Pierga
authors: Institut Curie, PSL Research University, SiRIC, Laboratory of Circulating Tumor Biomarkers, Paris, France; Institut Curie, PSL Research University, Department of Medical Oncology, Paris, France. Electronic address: francois-clement.bidard@curie.fr.
authors: Francois-Clement
authors: FC
authors: Bidard
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics; D021441:Carcinoma, Pancreatic Ductal / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000097:blood* / Q000235:genetics; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009154:Mutation; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D010183:Pancreatic Ducts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm
keywords: Circulating tumor DNA; Circulating tumor cells; Liquid biopsy; Pancreatic cancer