title: Relationship between HMGB1 and PAI-1 after allogeneic hematopoietic stem cell transplantation.
abstract: BACKGROUND
  Conditioning regimens including total body irradiation (TBI) or cyclophosphamide can mobilize high-mobility group box 1 (HMGB1) to peripheral blood. Additionally, increased plasminogen activator inhibitor (PAI)-1 levels are associated with post-allogeneic hematopoietic stem cell transplantation (aHSCT). However, changes to circulating levels of HMGB1 after aHSCT are poorly understood.
  
  
  METHODS
  The study cohort included 289 patients who underwent aHSCT at one of 25 institutions in Japan. We have investigated the relationship between HMGB1 and PAI-1 following aHSCT. A significant increase in HMGB1 levels occurred after conditioning treatment. Additionally, levels of HMGB1 at day 0 were significantly increased in TBI+ patients and cyclophosphamide/TBI patients.
  
  
  CONCLUSIONS
  Our data revealed that an increased level of HMGB1 at day 0 following aHSCT correlates with increased PAI-1 after aHSCT, which is consistent with previous reports. Increased HMGB1 at day 0 after a conditioning regimen may play a role in transplantation-associated coagulopathy following aHSCT, because PAI-1 can accelerate procoagulant activity.
authors: First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
authors: Shosaku
authors: S
authors: Nomura
authors: Department of Hematology and Oncology, Okayama University, Okayama, Japan.
authors: Yoshinobu
authors: Y
authors: Maeda
authors: First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
authors: Kazuyoshi
authors: K
authors: Ishii
authors: Division of Hematology, Hiroshima Red Cross Hospital, Hiroshima, Japan.
authors: Yuta
authors: Y
authors: Katayama
authors: Division of Hematology, Kidai Nara Hospital, Ikoma, Japan.
authors: Hideo
authors: H
authors: Yagi
authors: Department of Hematology, Naphrology, and Rheumatology, Akita University, Akita City, Japan.
authors: Naoto
authors: N
authors: Fujishima
authors: Division of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan.
authors: Shuichi
authors: S
authors: Ota
authors: Department of Hematology, Niigata University, Niigata, Japan.
authors: Masato
authors: M
authors: Moriyama
authors: Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Japan.
authors: Takayuki
authors: T
authors: Ikezoe
authors: Division of Hematology, Oita Hospital, Oita, Japan.
authors: Yasuhiko
authors: Y
authors: Miyazaki
authors: Division of Hematology, Meiwa Hospital, Nishinomiya, Japan.
authors: Kunio
authors: K
authors: Hayashi
authors: First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
authors: Shinya
authors: S
authors: Fujita
authors: First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
authors: Atsushi
authors: A
authors: Satake
authors: First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
authors: Tomoki
authors: T
authors: Ito
authors: Division of Hematology, Hiroshima Red Cross Hospital, Hiroshima, Japan.
authors: Taiichi
authors: T
authors: Kyo
authors: Department of Hematology and Oncology, Okayama University, Okayama, Japan.
authors: Mitsune
authors: M
authors: Tanimoto
keywords: HMGB1; PAI-1; TBI; aHSCT; transplantation-associated coagulopathy