title: Management of Candida biofilms: state of knowledge and new options for prevention and eradication.
abstract: Biofilms formed by Candida species (spp.) on medical devices represent a potential health risk. The focus of current research is searching for new options for the treatment and prevention of biofilm-associated infections using different approaches including modern nanotechnology. This review summarizes current information concerning the most relevant resistance/tolerance mechanisms to conventional drugs and a role of additional factors contributing to these phenomena in Candida spp. (mostly Candida albicans). Additionally, it provides an information update in prevention and eradication of a Candida biofilm including experiences with 'lock' therapy, potential utilization of small molecules in biomedical applications, and perspectives of using photodynamic inactivation in the control of a Candida biofilm.
authors: Comenius University in Bratislava, Faculty of Natural Sciences, Department of Microbiology & Virology, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovak Republic.
authors: Helena
authors: H
authors: Bujdáková
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D023181:Antimicrobial Cationic Peptides / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D002175:Candida / Q000187:drug effects / Q000502:physiology*; D002176:Candida albicans / Q000187:drug effects / Q000502:physiology; D002177:Candidiasis / Q000517:prevention & control / Q000628:therapy*; D019468:Disease Management; D025141:Drug Resistance, Fungal / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D036103:Nanotechnology; D010778:Photochemotherapy
chemical_list: D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides
keywords: Candida; biofilm; coating; nanoparticles; photodynamic inactivation; resistance; ‘lock’ therapy