title: Resistance Training in Spontaneously Hypertensive Rats with Severe Hypertension.
abstract: BACKGROUND
  Resistance training (RT) has been recommended as a non-pharmacological treatment for moderate hypertension. In spite of the important role of exercise intensity on training prescription, there is still no data regarding the effects of RT intensity on severe hypertension (SH).
  
  
  OBJECTIVE
  This study examined the effects of two RT protocols (vertical ladder climbing), performed at different overloads of maximal weight carried (MWC), on blood pressure (BP) and muscle strength of spontaneously hypertensive rats (SHR) with SH.
  
  
  METHODS
  Fifteen male SHR ENT#091;206 ± 10 mmHg of systolic BP (SBP)ENT#093; and five Wistar Kyoto rats (WKY; 119 ± 10 mmHg of SBP) were divided into 4 groups: sedentary (SED-WKY) and SHR (SED-SHR); RT1-SHR training relative to body weight (~40% of MWC); and RT2-SHR training relative to MWC test (~70% of MWC). Systolic BP and heart rate (HR) were measured weekly using the tail-cuff method. The progression of muscle strength was determined once every fifteen days. The RT consisted of 3 weekly sessions on non-consecutive days for 12-weeks.
  
  
  RESULTS
  Both RT protocols prevented the increase in SBP (delta - 5 and -7 mmHg, respectively; p > 0.05), whereas SBP of the SED-SHR group increased by 19 mmHg (p < 0.05). There was a decrease in HR only for the RT1 group (p < 0.05). There was a higher increase in strength in the RT2 (140%; p < 0.05) group as compared with RT1 (11%; p > 0.05).
  
  
  CONCLUSIONS
  Our data indicated that both RT protocols were effective in preventing chronic elevation of SBP in SH. Additionally, a higher RT overload induced a greater increase in muscle strength.
authors: Programa de Pós-Graduação em Educação Física, Universidade Católica de Brasília, Brasília, DF, Brazil.
authors: Rodrigo Vanerson Passos
authors: RV
authors: Neves
authors: Programa de Pós-Graduação em Educação Física, Universidade Católica de Brasília, Brasília, DF, Brazil.
authors: Michel Kendy
authors: MK
authors: Souza
authors: Divisão de Nefrologia, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Clévia Santos
authors: CS
authors: Passos
authors: Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, São Paulo, SP, Brazil.
authors: Reury Frank Pereira
authors: RF
authors: Bacurau
authors: Programa de Pós-Graduação em Educação Física, Universidade Católica de Brasília, Brasília, DF, Brazil.
authors: Herbert Gustavo
authors: HG
authors: Simoes
authors: Programa de Pós-Graduação em Educação Física, Universidade Católica de Brasília, Brasília, DF, Brazil.
authors: Jonato
authors: J
authors: Prestes
authors: Divisão de Nefrologia, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Mirian Aparecida
authors: MA
authors: Boim
authors: Laboratório de Imunologia Clínica e Experimental, Divisão de Nefrologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Niels Olsen Saraiva
authors: NO
authors: Câmara
authors: Programa de Pós-Graduação em Medicina Translacional, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Maria do Carmo Pinho
authors: Mdo C
authors: Franco
authors: Programa de Pós-Graduação em Educação Física, Universidade Católica de Brasília, Brasília, DF, Brazil.
authors: Milton Rocha
authors: MR
authors: Moraes
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D023421:Models, Animal; D053580:Muscle Strength / Q000502:physiology; D052580:Muscle Stretching Exercises; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D055070:Resistance Training