title: Gastrointestinal Disorders in Cystic Fibrosis.
abstract: Gastrointestinal (GI) manifestations commonly complicate the care of patients with cystic fibrosis (CF). Despite recent approval of CF transmembrane conductance regulator modulating agents that can improve pulmonary function, GI disorders continue to be relevant and require innovative therapies. This article discusses the most common GI complications of CF, including reflux, pancreatic insufficiency, small bowel intestinal overgrowth, distal intestinal obstruction syndrome, and GI malignancy, with emphasis on clinical presentation and management.
authors: Section of Digestive Diseases, Yale School of Medicine, 333 Cedar Street, 1080 LMP, New Haven, CT 06510, USA. Electronic address: david.assis@yale.edu.
authors: David N
authors: DN
authors: Assis
authors: Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
authors: Steven D
authors: SD
authors: Freedman
mesh_terms: D003550:Cystic Fibrosis / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D019468:Disease Management; D005767:Gastrointestinal Diseases / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D014943:Global Health; D006801:Humans; D009017:Morbidity / Q000639:trends
keywords: Constipation; Cystic fibrosis; Distal intestinal obstruction syndrome; Dysmotility; Gastrointestinal malignancy; Pancreas insufficiency; Pancreatitis; Reflux