title: Pruning Cancer's Evolutionary Tree with Lesion-Directed Therapy.
abstract: Next-generation sequencing of spatially and temporally separated biopsies and circulating tumor DNA directs therapy in response to tumor evolution and acquired resistance in colorectal cancer.
authors: University College London Cancer Institute and The Francis Crick Institute, London, United Kingdom.
authors: Crispin T
authors: CT
authors: Hiley
authors: University College London Cancer Institute and The Francis Crick Institute, London, United Kingdom. charles.swanton@crick.ac.uk.
authors: Charles
authors: C
authors: Swanton
mesh_terms: D015179:Colorectal Neoplasms; D004273:DNA, Neoplasm / Q000235:genetics*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans
chemical_list: D004273:DNA, Neoplasm