title: [Effect of Agonists and Antagonists of α2 Adrenergic Receptors on Choice of Reinforcement Value in Rats with Different Levels of Impulsivity].
abstract: The influence of drugs, agonist (clonidine) and antagonist (yohimbine) of α2-adrenergic receptors 5-HT2 on the behavior of rats tested by the method of choice to the value of reinforcement was investigated. Based on the selection of a rat the pedal for immediate poor and delayed valuable reinforcement rats were divided into 3 groups. Rats, in most cases, choosing valuable delayed reinforcements were classified as low-impulsive, those who mainly chosen poor immediate reinforcement to the high-impulsive group. Rats who were not able to determine, was ambivalent group. Administration (i.p.) of the α2-adrenergic receptors agonist clonidine resulted in a reduction of the select valuable delayed reinforcement by low-impulsive animals and increasing the number of missing responses of pressing the pedal in high-impulsive animals. Clonidine also reduced the latency of nose-poking in all groups of animals. The antagonist of these receptors yohimbine did not cause changes in the choice of the reinforcement in all groups of animals. At the same time yohimbine caused a significant reduction in the number of missing responses. The results suggest that the effect of drugs used in this work on α2-adrenergic receptors depends on the individual feature of rats, in particular from high and low degree of impulsivity.
authors: M I
authors: MI
authors: Zaichenko
authors: G Kh
authors: GKh
authors: Merzhanova
authors: D A
authors: DA
authors: Bazhenova
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects / Q000502:physiology*; D003000:Clonidine / Q000008:administration & dosage; D018492:Dopamine Antagonists / Q000008:administration & dosage; D007175:Impulsive Behavior / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*; D012054:Reinforcement, Psychology; D015016:Yohimbine / Q000008:administration & dosage
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D018492:Dopamine Antagonists; D018341:Receptors, Adrenergic, alpha-2; D015016:Yohimbine; D003000:Clonidine