title: Analysis of Toll-Like Receptor 2 Polymorphism (rs5743704) in Saudi Patients with Primary Open-Angle Glaucoma.
abstract: OBJECTIVE
  To investigate whether the single-nucleotide polymorphism (SNP) rs5743704 in the toll-like receptor 2 gene is associated with primary open-angle glaucoma (POAG) or any of its clinical indices in a Saudi cohort.
  
  
  METHODS
  Ninety-five unrelated POAG cases and 95 controls of Saudi origin were genotyped utilizing a TaqMan(®) assay. The association between genotypes and various clinical indices important for POAG were investigated.
  
  
  RESULTS
  The genotypic and allelic frequencies among cases were not significantly different when compared to controls. The minor allele frequency was 0.021 in cases and 0.011 in controls. No significant association was seen with intraocular pressure and cup/disc ratio. However, carriers of the C/A genotype had higher number of anti-glaucoma medications compared to controls (p = 0.04).
  
  
  CONCLUSIONS
  SNP rs5773704 is not associated with POAG in a Saudi population. Despite sample size limitation, the association of the minor allele A with higher number of anti-glaucoma medications suggests a possible indirect role for this SNP in predicting disease severity.
authors: 1 Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .|2 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors: Altaf A
authors: AA
authors: Kondkar
authors: 1 Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .|2 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors: Ahmed
authors: A
authors: Mousa
authors: 1 Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .|2 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors: Taif A
authors: TA
authors: Azad
authors: 1 Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .|2 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors: Tahira
authors: T
authors: Sultan
authors: 1 Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .|2 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors: Essam A
authors: EA
authors: Osman
authors: 1 Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .|2 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors: Saleh A
authors: SA
authors: Al-Obeidan
authors: 1 Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .|2 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .|3 Department of Ophthalmology, College of Medicine, University of Florida , Jacksonville, Florida.
authors: Khaled K
authors: KK
authors: Abu-Amero
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D060005:Genotyping Techniques / Q000379:methods; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006801:Humans; D007429:Intraocular Pressure / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012529:Saudi Arabia; D051195:Toll-Like Receptor 2 / Q000235:genetics* / Q000378:metabolism
chemical_list: C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2