title: Pathology of premalignant colorectal neoplasia.
abstract: Colorectal cancer is a heterogeneous oncological disease that develops through several molecular pathways. Each pathway is associated with specific neoplastic precursor lesions. Classification of colorectal polyps and the molecular features of associated colorectal cancers have undergone significant changes. An understanding of colorectal carcinogenesis and the molecular features of colorectal carcinomas is now regarded as necessary for personalized treatment and management of patients with colon cancer, and even for patients undergoing screening colonoscopy for early detection and prevention of colorectal cancer. In the present review, we describe the pathological and molecular features of epithelial precursor lesions involved in the early phases of colorectal carcinogenesis.
authors: Department of Pathology, Yale University School of Medicine, New Haven, USA.
authors: Joanna A
authors: JA
authors: Gibson
authors: Department of Pathology, Brigham and Women's Hospital, Boston, USA.
authors: Robert D
authors: RD
authors: Odze
mesh_terms: D000236:Adenoma / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D003111:Colonic Polyps / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D011230:Precancerous Conditions / Q000473:pathology*
keywords: adenoma; hyperplastic polyp; malignant polyp; sessile serrated adenoma/polyptraditional serrated adenoma