title: Immunoglobulin-induced hemolysis, splenomegaly and inflammation in patients with antibody deficiencies.
abstract: IgG replacement for primary antibody deficiencies is a safe treatment administered to prevent recurrent infections and reduce mortality. Recently, several reports described acute hemolytic episodes following IgG administration due to a passive transfer of blood group alloantibodies, including anti-A, anti-B, as well as anti-Rh antibodies. Here, we reviewed and discussed the consequences of passively transferred RBCs antibodies. The chronic passive transfer of alloantibodies might also cause a subclinical condition due to a compensated extravascular chronic hemolysis with poorly understood consequences. This phenomenon might possibly represent an unrecognized cause of splenomegaly and might contribute to inflammation in patients with primary antibody deficiencies.
authors: a Centre for Primary Immune Deficiencies, Department of Molecular Medicine , Sapienza University of Rome , Rome , Italy.
authors: Federica
authors: F
authors: Pulvirenti
authors: a Centre for Primary Immune Deficiencies, Department of Molecular Medicine , Sapienza University of Rome , Rome , Italy.
authors: Guido
authors: G
authors: Granata
authors: b Unit of Immunohematology and Transfusion Medicine , Sapienza University of Rome , Rome , Italy.
authors: Gabriella
authors: G
authors: Girelli
authors: a Centre for Primary Immune Deficiencies, Department of Molecular Medicine , Sapienza University of Rome , Rome , Italy.
authors: Isabella
authors: I
authors: Quinti
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D006461:Hemolysis / Q000276:immunology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy*; D007249:Inflammation; D007518:Isoantibodies / Q000276:immunology / Q000378:metabolism*; D013163:Splenomegaly / Q000209:etiology
chemical_list: D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies
keywords: Common Variable Immune Deficiency; Hemolysis; Immunoglobulin replacement therapy; Immunoglobulin-Induced Hemolysis; Inflammation; Primary Antibody Defects; Splenomegaly