title: Analytical Strategies for the Determination of Norepinephrine Reuptake Inhibitors in Pharmaceutical Formulations and Biological Fluids.
abstract: Norepinephrine reuptake inhibitors (NRIs) are a class of antidepressant drugs that act as reuptake inhibitors for the neurotransmitters norepinephrine and epinephrine. The present review provides an account of analytical methods published in recent years for the determination of NRI drugs. NRIs are atomoxetine, reboxetine, viloxazine and maprotiline. NRIs with less activity at other sites are mazindol, bupropion, tapentadol, and teniloxazine. This review focuses on the analytical methods including chromatographic, spectrophotometric, electroanalytical, and electrophoresis techniques for NRI analysis from pharmaceutical formulations and biological samples. Among all of the published methods, liquid chromatography with UV-vis or MS-MS detection is the most popular technique. The most the common sample preparation techniques in the analytical methods for NRIs include liquid-liquid extraction and solid-phase extraction. Besides the analytical methods for single components, some of the simultaneous determinations are also included in this review.
authors: a School of Health, Siirt University , Siirt , Turkey.
authors: Cafer
authors: C
authors: Saka
mesh_terms: D000928:Antidepressive Agents / Q000032:analysis* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D055664:Electrochemical Techniques; D006801:Humans; D008163:Luminescent Measurements; D013058:Mass Spectrometry; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors / Q000032:analysis* / Q000097:blood
chemical_list: D000928:Antidepressive Agents; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors
keywords: analytical methods; antidepressant drugs; biological fluids; norepinephrine reuptake inhibitors; pharmaceutical formulations