title: Impact of Body Weight Loss on Recurrence After Curative Gastrectomy for Gastric Cancer.
abstract: BACKGROUND
  This study was designed to assess the prognostic role of body weight loss (BWL) after curative gastrectomy for gastric cancer patients.
  
  
  METHODS
  We analyzed a total of 102 consecutive patients who underwent curative gastrectomy for stage II or III gastric cancer between 2005 and 2011. Postoperative BWL during the first 6 months in patients was calculated from their hospital records.
  
  
  RESULTS
  Postoperative BWL was significantly higher in patients with tumours in the upper stomach, total gastrectomy, or subsequent recurrence. A postoperative BWL of 12% was the optimal cut-off value, which was strongly associated with subsequent recurrence. Patients with a postoperative BWL of 12% or higher did not have poorer overall survival but did have significantly poorer disease-free survival than patients with BWL of less than 12%. Cox proportional hazard analyses revealed that a postoperative BWL of 12% or higher was an independent prognostic factor of poor disease-free survival.
  
  
  CONCLUSIONS
  High BWL after curative gastrectomy is related to recurrence in patients with gastric cancer.
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
authors: Hidemasa
authors: H
authors: Kubo
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan skomatsu@koto.kpu-m.ac.jp.
authors: Shuhei
authors: S
authors: Komatsu
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
authors: Daisuke
authors: D
authors: Ichikawa
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
authors: Tsutomu
authors: T
authors: Kawaguchi
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
authors: Toshiyuki
authors: T
authors: Kosuga
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
authors: Kazuma
authors: K
authors: Okamoto
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
authors: Hirotaka
authors: H
authors: Konishi
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
authors: Atsushi
authors: A
authors: Shiozaki
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
authors: Hitoshi
authors: H
authors: Fujiwara
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
authors: Eigo
authors: E
authors: Otsuji
mesh_terms: D018450:Disease Progression; D018572:Disease-Free Survival; D005743:Gastrectomy / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D007564:Japan; D053208:Kaplan-Meier Estimate; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss
keywords: Postoperative body weight loss; gastric cancer; recurrence