title: Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39-64 Years.
abstract: Low serum 25-hydroxyvitamin D (25(OH)D) levels are implicated as a risk factor for hip and spine fractures. Studies of the relation between 25(OH)D levels and fractures have primarily involved elderly osteoporosis patients or patients with fractures; however, the serum 25(OH)D and parathyroid hormone (PTH) status in younger adult populations remains largely unknown. We evaluated serum 25(OH)D and intact PTH levels in 411 women aged 39-64 years who were not receiving medication for osteoporosis or other bone diseases. Serum 25(OH)D levels were positively correlated with age (P = 0.019), whereas intact PTH levels were inversely correlated with 25(OH)D levels (P < 0.001). Thus, low vitamin D levels with high intact PTH levels were more common in younger than in older women. Our data show that serum 25(OH)D insufficiency could be a more serious concern in the younger population than had been previously anticipated. Because serum 25(OH)D insufficiency is reportedly a risk factor for hip and spine fracture, the number of fracture patients could increase in the future, suggesting that we may need to correct the serum vitamin D/intact PTH status to prevent future osteoporosis.
authors: Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan.
authors: Takeshi
authors: T
authors: Miyamoto
authors: Eri
authors: E
authors: Katsuyama
authors: Hiroya
authors: H
authors: Kanagawa
authors: Atsuhiro
authors: A
authors: Fujie
authors: Hiroya
authors: H
authors: Miyamoto
authors: Shigeyuki
authors: S
authors: Yoshida
authors: Tomoaki
authors: T
authors: Mori
authors: Kana
authors: K
authors: Miyamoto
authors: Yuiko
authors: Y
authors: Sato
authors: Tami
authors: T
authors: Kobayashi
authors: Masaya
authors: M
authors: Nakamura
authors: Morio
authors: M
authors: Matsumoto
authors: Yuji
authors: Y
authors: Nishiwaki
authors: Hiroshi
authors: H
authors: Hirose
authors: Takeshi
authors: T
authors: Kanda
authors: Ikuo
authors: I
authors: Saito
authors: Yoshiaki
authors: Y
authors: Toyama
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D006620:Hip Fractures / Q000517:prevention & control*; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000517:prevention & control*; D010281:Parathyroid Hormone / Q000097:blood*; D017698:Postmenopause; D017697:Premenopause; D011322:Primary Prevention; D012307:Risk Factors; D016103:Spinal Fractures / Q000517:prevention & control*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D