title: The Natural Substance MS-10 Improves and Prevents Menopausal Symptoms, Including Colpoxerosis, in Clinical Research.
abstract: Many natural substances were screened to develop nutraceuticals that reduce menopausal symptoms. A complex of Cirsium japonicum var. maackii and Thymus vulgaris extracts, named MS-10, had significant positive effects. Under a low concentration of estrogen, which represents postmenopausal physiological conditions, MS-10 had beneficial effects on estrogen receptor-expressing MCF-7 cells by reversibly enhancing estrogen activity. In addition, in the ovariectomized rat model, changes in bone-specific alkaline phosphatase activity and osteocalcin, as well as low-density lipoprotein cholesterol and triglyceride levels were significantly decreased by MS-10. These results show that MS-10 protected bone health and reduced metabolic disturbances. Furthermore, in a clinical study, all menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, vertigo, fatigue, rheumatic pain, palpitations, formication, and headache, as well as colpoxerosis, were significantly improved by taking MS-10 for 90 days. Therefore, the evidence supports that MS-10 is an effective natural substance that can safely improve menopausal symptoms, including colpoxerosis.
authors: 1 Department of Anatomy and Cell Biology and Neurology, College of Medicine, Chung-Ang University , Seoul, Korea.|2 Famenity Biomedical Research Center, Famenity, Inc. , Gyeonggi, Korea.
authors: Yoo-Hun
authors: YH
authors: Noh
authors: 3 Natural Pharmaceutical R&D Center, Naturesense, Inc. , Gyeonggi, Korea.
authors: Do-Hee
authors: DH
authors: Kim
authors: 1 Department of Anatomy and Cell Biology and Neurology, College of Medicine, Chung-Ang University , Seoul, Korea.
authors: Seung-Ah
authors: SA
authors: Lee
authors: 2 Famenity Biomedical Research Center, Famenity, Inc. , Gyeonggi, Korea.
authors: Xing Fu
authors: XF
authors: Yin
authors: 1 Department of Anatomy and Cell Biology and Neurology, College of Medicine, Chung-Ang University , Seoul, Korea.
authors: Jiae
authors: J
authors: Park
authors: 4 Department of Physiology, College of Medicine, Chung-Ang University , Seoul, Korea.
authors: Moo Yeol
authors: MY
authors: Lee
authors: 1 Department of Anatomy and Cell Biology and Neurology, College of Medicine, Chung-Ang University , Seoul, Korea.
authors: Won Bok
authors: WB
authors: Lee
authors: 5 Department of Neurosurgery, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine , Seoul, Korea.
authors: Sang Hyung
authors: SH
authors: Lee
authors: 6 Department of Internal Medicine, The Catholic University of Korea College of Medicine , Gyeonggi, Korea.
authors: Jae Kwang
authors: JK
authors: Kim
authors: 7 Department of Food Science and Nutrition, College of Natural Science, Dankook University , Chungnam, Korea.
authors: Sung-Su
authors: SS
authors: Kim
authors: 7 Department of Food Science and Nutrition, College of Natural Science, Dankook University , Chungnam, Korea.
authors: Yoonhwa
authors: Y
authors: Jeong
authors: 8 Department of Urology, College of Medicine, Chung-Ang University , Seoul, Korea.
authors: Soon-Chul
authors: SC
authors: Myung
authors: 9 Division of Immunobiology, Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine , Gyeonggi, Korea.
authors: Tae Jin
authors: TJ
authors: Kim
authors: 10 Department of Food Science and Nutrition, College of Natural Science, Hallym University , Gangwon, Korea.
authors: Il-Jun
authors: IJ
authors: Kang
mesh_terms: D000818:Animals; D031180:Cirsium / Q000737:chemistry*; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D008593:Menopause / Q000187:drug effects* / Q000378:metabolism; D008875:Middle Aged; D015675:Osteocalcin / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D046930:Thymus Plant / Q000737:chemistry*; D014623:Vaginal Diseases / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*
chemical_list: D008077:Lipoproteins, LDL; D010936:Plant Extracts; D015675:Osteocalcin
keywords: Kupperman's Index; MS-10; colpoxerosis; menopause; ovariectomized rat