title: Comparative Anatomy of Phagocytic and Immunological Synapses.
abstract: The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types. However, growing experimental evidence shows that a very close series of molecular and cellular events control these two processes. Thus, the tight and dynamic interplay between receptor signaling, actin and microtubule cytoskeleton, and targeted vesicle traffic are all critical features to build functional phagosomes and immunological synapses. Interestingly, both phagocytic cups and immunological synapses display particular spatial and temporal patterns of receptors and signaling molecules, leading to the notion of "phagocytic synapse." Here, we discuss both types of structures, their organization, and the mechanisms by which they are generated and regulated.
authors: U1016, Institut Cochin, INSERM, Paris, France; UMR 8104, CNRS, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors: Florence
authors: F
authors: Niedergang
authors: Lymphocyte Cell Biology Unit, Department of Immunology, Institut Pasteur, Paris, France; U1221, INSERM, Paris, France.
authors: Vincenzo
authors: V
authors: Di Bartolo
authors: Lymphocyte Cell Biology Unit, Department of Immunology, Institut Pasteur, Paris, France; U1221, INSERM, Paris, France.
authors: Andrés
authors: A
authors: Alcover
keywords: actin; endocytosis; exocytosis; immune receptor; immunological synapse; microtubules; phagocytosis; signal transduction