title: Multifunctional Nanocarpets for Cancer Theranostics: Remotely Controlled Graphene Nanoheaters for Thermo-Chemosensitisation and Magnetic Resonance Imaging.
abstract: A new paradigm in cancer theranostics is enabled by safe multifunctional nanoplatform that can be applied for therapeutic functions together with imaging capabilities. Herein, we develop a multifunctional nanocomposite consisting of Graphene Oxide-Iron Oxide -Doxorubicin (GO-IO-DOX) as a theranostic cancer platform. The smart magnetic nanoplatform acts both as a hyperthermic agent that delivers heat when an alternating magnetic field is applied and a chemotherapeutic agent in a cancer environment by providing a pH-dependent drug release to administer a synergistic anticancer treatment with an enhanced T2 contrast for MRI. The novel GO-IO-DOX nanocomposites were tested in vitro and were observed to exhibit an enhanced tumoricidal effect through both hyperthermia and cancer cell-specific DOX release along with an excellent MRI performance, enabling a versatile theranostic platform for cancer. Moreover the localized antitumor effects of GO-IO-DOX increased substantially as a result of the drug sensitization through repeated application of hyperthermia.
authors: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors: Arathyram
authors: A
authors: Ramachandra Kurup Sasikala
authors: Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors: Reju George
authors: RG
authors: Thomas
authors: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea.|Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors: Afeesh Rajan
authors: AR
authors: Unnithan
authors: Department of Mechatronics Engineering, Jeju National University, Jeju, 690-756, Republic of Korea.
authors: Balasubramaniam
authors: B
authors: Saravanakumar
authors: Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors: Yong Yeon
authors: YY
authors: Jeong
authors: Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors: Chan Hee
authors: CH
authors: Park
authors: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea.|Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors: Cheol Sang
authors: CS
authors: Kim
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D005290:Ferric Compounds / Q000737:chemistry* / Q000494:pharmacology; D006108:Graphite / Q000737:chemistry*; D006979:Hyperthermia, Induced / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry; D051379:Mice; D041681:NIH 3T3 Cells; D000068936:Theranostic Nanomedicine
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D006108:Graphite; D004317:Doxorubicin