title: Repression of harmful meiotic recombination in centromeric regions.
abstract: During the first division of meiosis, segregation of homologous chromosomes reduces the chromosome number by half. In most species, sister chromatid cohesion and reciprocal recombination (crossing-over) between homologous chromosomes are essential to provide tension to signal proper chromosome segregation during the first meiotic division. Crossovers are not distributed uniformly throughout the genome and are repressed at and near the centromeres. Rare crossovers that occur too near or in the centromere interfere with proper segregation and can give rise to aneuploid progeny, which can be severely defective or inviable. We review here how crossing-over occurs and how it is prevented in and around the centromeres. Molecular mechanisms of centromeric repression are only now being elucidated. However, rapid advances in understanding crossing-over, chromosome structure, and centromere functions promise to explain how potentially deleterious crossovers are avoided in certain chromosomal regions while allowing beneficial crossovers in others.
authors: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA, United States. Electronic address: mnambiar@fredhutch.org.
authors: Mridula
authors: M
authors: Nambiar
authors: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA, United States. Electronic address: gsmith@fhcrc.org.
authors: Gerald R
authors: GR
authors: Smith
mesh_terms: D000818:Animals; D002503:Centromere / Q000378:metabolism*; D020090:Chromosome Segregation / Q000235:genetics; D053903:DNA Breaks, Double-Stranded; D005785:Gene Conversion; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D011995:Recombination, Genetic
keywords: Aneuploidy; Centromeres; Chromosome segregation; Crossing-over; Homologous recombination; Meiosis