title: Effects of some cations on the formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a model system.
abstract: The present study aimed to investigate in detail the changes to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its precursors in the presence of some cations (i.e., K(+), Na(+), Ca(2+), Mg(2+), Fe(2+) and Fe(3+)) in a creatinine/phenylacetaldehyde model system. Results showed that PhIP yields decreased when Fe(2+)and Fe(3+) were added to a mixture of phenylacetaldehyde and creatinine. This decrease may be attributed to the fact that Fe(3+) can form complexes with various properties with creatinine and accelerate creatinine degradation. This pathway can disturb the reaction with phenylacetaldehyde, influence aldol condensation product formation, and suppress PhIP formation. Furthermore, Ca(2+)and Mg(2+) enhanced PhIP content. Such enhancement may be attributed to the fact that CaCl2 and MgCl2 promote aldol and aldol condensation product reactions with ammonia and formaldehyde. A possible mechanism for the action of cations during PhIP formation in a model system is also proposed.
authors: College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China.
authors: Di
authors: D
authors: Yu
authors: College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou 510640, China. Electronic address: shujuanyu8@gmail.com.
authors: Shu-Juan
authors: SJ
authors: Yu
mesh_terms: D000079:Acetaldehyde / Q000031:analogs & derivatives / Q000737:chemistry; D002412:Cations / Q000737:chemistry*; D003404:Creatinine / Q000737:chemistry; D005557:Formaldehyde / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D008956:Models, Chemical
chemical_list: D002412:Cations; D007093:Imidazoles; D005557:Formaldehyde; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; D003404:Creatinine; D000079:Acetaldehyde; C013192:phenylacetaldehyde
keywords: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP); 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (PubChem CID: 1530); Aldol condensation product; Creatinine; Creatinine (PubChem CID: 588); Phenylacetaldehyde; Phenylacetaldehyde (PubChem CID: 998); Some cations; o-Phenylenediamine (OPD) (PubChem CID: 7243)