title: Leukocyte chemotactic factor 2 amyloidosis (ALECT2) is a common form of renal amyloidosis among Egyptians.
abstract: Large case series of renal amyloidosis subtypes have recently been published in the United States and Europe showing AL amyloidosis to be the predominant subtype in this part of the world. However, the most common subtypes of renal amyloidosis throughout the rest of the world are unknown. We present here the first large case series detailing the subtypes of renal amyloidosis among Egyptians. In this population, AA amyloidosis was the most common type of amyloidosis on renal biopsy at 48%. The newly described leukocyte chemotactic factor 2 amyloidosis (ALECT2) was the second most common type and represented nearly one-third of renal amyloid cases at 31%. AL accounted for only 20% of cases. The pathologic findings in ALECT2 cases were similar to those previously described in other case series. Thus ALECT2, which was initially thought to affect mainly Hispanics in the United States, appears to represent an important and likely underrecognized etiology of chronic kidney disease among Egyptians and probably in other ethnic groups around the world.
authors: Nephropath, Little Rock, AR, USA.
authors: Christopher P
authors: CP
authors: Larsen
authors: Pathology Department, Beni-Suef University, Beni-Suef, Egypt.|Pathlab, Cairo, Egypt.
authors: Wesam
authors: W
authors: Ismail
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
authors: Paul J
authors: PJ
authors: Kurtin
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
authors: Julie A
authors: JA
authors: Vrana
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
authors: Surendra
authors: S
authors: Dasari
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
authors: Samih H
authors: SH
authors: Nasr
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D018912:Arabs; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology / Q000209:etiology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C103468:LECT2 protein, human