title: Impact of sarcopenia on long-term mortality following endovascular aneurysm repair.
abstract: Sarcopenia, also known as a reduction of skeletal muscle mass, is a patient-specific risk factor for vascular and cancer patients. However, there are no data on abdominal aortic aneurysm (AAA) patients treated with endovascular aneurysm repair (EVAR) who have sarcopenia. To determine the impact of sarcopenia on mortality following EVAR, we retrospectively reviewed 200 patients treated with EVAR by estimating muscle mass on abdominal computed tomography (CT) scans. Mortality was analyzed according to its presence (n=25) or absence (n=175). Sarcopenia was more common in women than men (32.0% vs 9.7%; p=0.005). Patients with sarcopenia had an increased risk of mortality compared to those without (76% vs 48%; p=0.016). Of note, the overall mortality rate was 51% with a median follow up of 8.4 years (interquartile range, 5.3-11.7). In conclusion, the presence of sarcopenia on a CT scan is an important predictor of long-term mortality in patients treated for AAA with EVAR. Pending further study, these data suggest that sarcopenia may aid in pre-procedural long-term survival assessment of patients undergoing EVAR.
authors: Department of Surgery, Vascular Medicine Division, Greenville Health System, Greenville, SC, USA.
authors: Allyson L
authors: AL
authors: Hale
authors: Department of Surgery, Vascular Medicine Division, Greenville Health System, Greenville, SC, USA.
authors: Kayla
authors: K
authors: Twomey
authors: Department of Surgery, Vascular Medicine Division, Greenville Health System, Greenville, SC, USA.
authors: Joseph A
authors: JA
authors: Ewing
authors: Department of Surgery, Vascular Medicine Division, Greenville Health System, Greenville, SC, USA.
authors: Eugene M
authors: EM
authors: Langan
authors: Department of Surgery, Vascular Medicine Division, Greenville Health System, Greenville, SC, USA.
authors: David L
authors: DL
authors: Cull
authors: Department of Surgery, Vascular Medicine Division, Greenville Health System, Greenville, SC, USA BGray@ghs.org.
authors: Bruce H
authors: BH
authors: Gray
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D001027:Aortography / Q000379:methods; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000401:mortality*; D000072226:Computed Tomography Angiography; D057510:Endovascular Procedures / Q000009:adverse effects / Q000401:mortality*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D055948:Sarcopenia / Q000000981:diagnostic imaging / Q000401:mortality*; D013997:Time Factors; D016896:Treatment Outcome
keywords: abdominal aortic aneurysm; endovascular aneurysm repair; mortality; sarcopenia