title: MicroRNAs in heart failure: from biomarker to target for therapy.
abstract: MicroRNAs (miRNAs) are increasingly recognized to play important roles in cardiovascular diseases, including heart failure. These small, non-coding RNAs have been identified in tissue and are involved in several pathophysiological processes related to heart failure, such as cardiac fibrosis and hypertrophy. As a result, miRNAs have become interesting novel drug targets, leading to the development of miRNA mimics and antimirs. MicroRNAs are also detected in the circulation, and are proposed as potential diagnostic and prognostic biomarkers in heart failure. However, their role and function in the circulation remains to be resolved. Here, we review the potential roles of miRNAs as circulating biomarkers and as targets for therapy.
authors: Department of Cardiology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
authors: Eline L
authors: EL
authors: Vegter
authors: Department of Cardiology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
authors: Peter
authors: P
authors: van der Meer
authors: Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands.
authors: Leon J
authors: LJ
authors: de Windt
authors: Department of Cardiology, Heart Failure Research Centre, Academic Medical Centre, Amsterdam, the Netherlands.
authors: Yigal M
authors: YM
authors: Pinto
authors: Department of Cardiology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
authors: Adriaan A
authors: AA
authors: Voors
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000378:metabolism; D006332:Cardiomegaly / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D002908:Chronic Disease; D005355:Fibrosis; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009206:Myocardium / Q000473:pathology; D011379:Prognosis; D013318:Stroke Volume
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Antimir; Circulation; Heart failure; MicroRNAs