title: Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction.
abstract: Mild therapeutic hypothermia of 32-35°C improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore, in experimental studies on infarcted model and pilot studies on conscious patients with acute myocardial infarction, therapeutic hypothermia successfully reduced infarct size and microvascular resistance. Therefore, mild therapeutic hypothermia has received an attention as a promising solution for reduction of infarction size after acute myocardial infarction which are not completely solved despite of optimal reperfusion therapy. Nevertheless, the results from randomized clinical trials failed to prove the cardioprotective effects of therapeutic hypothermia or showed beneficial effects only in limited subgroups. In this article, we reviewed rationale for therapeutic hypothermia and possible mechanisms from previous studies, effective methods for clinical application to the patients with acute myocardial infarction, lessons from current clinical trials and future directions.
authors: Department of Internal Medicine, Green Hospital, Seoul, Korea.|Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: In Sook
authors: IS
authors: Kang
authors: Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
authors: Ikeno
authors: I
authors: Fumiaki
authors: Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. pwb423@ewha.ac.kr.
authors: Wook Bum
authors: WB
authors: Pyun
mesh_terms: D000208:Acute Disease; D001831:Body Temperature; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D013997:Time Factors; D016896:Treatment Outcome
keywords: Hypothermia, induced; myocardial infarction; myocardial reperfusion injury