title: Prognostic Significance of Aquaporin 5 Expression in Non-small Cell Lung Cancer.
abstract: BACKGROUND
  Aquaporins are water channel proteins that play a major role in the movement of water in various human tissues. Recently, it has been found that aquaporins have influence in the carcinogenesis of human malignancies. We analyzed the prognostic impact of aquaporin 5 (AQP5) in non-small lung cancer (NSCLC).
  
  
  METHODS
  Seventy-six cases of NSCLC were studied, including 44 cases of adenocarcinoma (ADC) and 32 cases of squamous cell carcinoma (SQCC). Tissue microarray was constructed and immunohistochemical staining for AQP5 was performed.
  
  
  RESULTS
  AQP5 was positive in 59.2% of the total enrolled NSCLCs (63.7% in ADC and 53.1% in SQCC). The difference in expression of AQP5 according to the histologic grade of the tumor was significant (p<.047), but not in a serial order. When ADC and SQCC were separately evaluated, no significant difference was observed according to the histologic grade of the tumor (p=.076 in ADC and p=.631 in SQCC). No difference was observed between AQP5 expression and other demographic data and tumor characteristics. Disease-free survival (DFS) was higher in AQP5 negative cases than positive cases in ADC (p=.047), but no significance was found in SQCC (p=.068). We were unable to find a significance between AQP5 overexpression and overall survival in either ADC (p=.210) or SQCC (p=.533).
  
  
  CONCLUSIONS
  AQP5 expression is associated with DFS in ADC of the lung and tumor grade of NSCLC. The present study suggests that AQP5 can be a prognostic factor of NSCLC.
authors: Department of Pathology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Young Min
authors: YM
authors: Jo
authors: Department of Pathology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Tae In
authors: TI
authors: Park
authors: Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Hwa Young
authors: HY
authors: Lee
authors: Department of Pathology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Ji Yun
authors: JY
authors: Jeong
authors: Biostatistics, Biomedical Research Institute, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Won Kee
authors: WK
authors: Lee
keywords: Adenocarcinoma; Aquaporin 5; Carcinoma, non-small cell lung; Carcinoma, squamous cell