title: Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia.
abstract: This study was conducted to investigate the outcomes of patients with chronic myeloid leukemia (CML) who discontinued tyrosine kinase inhibitor (TKI) treatment. A single-center retrospective analysis was performed, including 46 chronic-phase (CP) CML patients who achieved complete molecular response (CMR) with TKIs. TKI treatment was discontinued in 13 patients based on their requests. The BCR-ABL transcript levels were monitored in the peripheral blood by quantitative polymerase chain reaction analysis following treatment discontinuation. Of the 13 patients who discontinued TKI treatment, 7 remained in CMR, with a median follow-up of 26 months (range, 10-60 months). The remaining 6 patients lost CMR following TKI discontinuation; 2 of these patients achieved a second CMR following re-administration of TKIs, 2 patients spontaneously achieved CMR and 2 remained in complete hematological response (CHR) without TKI treatment with a median follow-up of 29.5 months (range, 10-52 months). In conclusion, the survival of patients who lost CMR following TKI discontinuation may not be affected, even without re-administration of TKIs. Vigilant observation is recommended for such patients. The limitations of this study included the small patient sample, retrospective design and patient heterogeneity. Therefore, the results must be interpreted with caution.
authors: Department of Hematology, Hakodate Municipal Hospital, Hakodate, Hokkaido 041-8680, Japan.
authors: Yutaka
authors: Y
authors: Tsutsumi
authors: Department of Hematology, Hakodate Municipal Hospital, Hakodate, Hokkaido 041-8680, Japan.
authors: Shinichi
authors: S
authors: Ito
authors: Department of Hematology, Hakodate Municipal Hospital, Hakodate, Hokkaido 041-8680, Japan.
authors: Hiroyuki
authors: H
authors: Ohigashi
authors: Department of Hematology, Hakodate Municipal Hospital, Hakodate, Hokkaido 041-8680, Japan.
authors: Souichi
authors: S
authors: Shiratori
authors: Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan.
authors: Takanori
authors: T
authors: Teshima
keywords: chronic myeloid leukemia; tyrosine kinase inhibitors