title: Interdisciplinary care programme to improve self-management for cancer patients undergoing stem cell transplantation: a prospective non-randomised intervention study.
abstract: The purpose of this single-centre prospective non-randomised study was to evaluate the effectiveness of an interdisciplinary care programme to enhance self-management in patients with haematopoietic stem cell transplantation (HSCT). Patients undergoing HSCT, aged >14 years with informed consent were recruited (n = 79). Patients in the intervention group (IG) received standard care plus the SCION-HSCT intervention to counteract three problems after HSCT: muscle weakness, oral mucositis and malnutrition. Control group patients received standard care. Primary endpoint was global health-related quality of life (HRQoL) at discharge (EORTC QLQ C30 v. 3.0). Baseline characteristics were balanced between both groups, except physical performance (ECOG) being significantly lower for patients of the IG. At discharge, no group differences could be seen regarding HRQoL. Non-confirmatory post hoc analyses showed for patients of the IG a shorter duration of hospitalisation (MD -10.90; 95% CI -18.05 to -3.75) and increased activity during hospitalisation (MD 2.44; 95% CI 1.27-3.61). In conclusion, clinical effectiveness of the intervention could not be proven with respect to the aspired improvement of HRQoL. However, the nurse-led interdisciplinary caring programme could be carried out in every day ward routine. Further research should focus on working mechanisms of complex interventions aiming to improve HRQoL of patients undergoing HSCT.
authors: Medical Faculty, Institute for Health and Nursing Science, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors: H
authors: H
authors: Schmidt
authors: Medical Faculty, Institute for Health and Nursing Science, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors: S
authors: S
authors: Boese
authors: Medical Faculty, Institute for Health and Nursing Science, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors: A
authors: A
authors: Bauer
authors: Medical Faculty, Institute for Health and Nursing Science, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors: M
authors: M
authors: Landenberger
authors: Department of Sports Science, Institute of Communication, Media and Sports, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors: A
authors: A
authors: Lau
authors: Department of Sports Science, Institute of Communication, Media and Sports, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors: O
authors: O
authors: Stoll
authors: University Hospital Halle, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors: H-J
authors: HJ
authors: Schmoll
authors: University Hospital Halle, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors: C
authors: C
authors: Mauz-Koerholz
authors: Faculty of Medicine, Centre for Health and Society, Heinrich Heine University, Düsseldorf, Germany.|Institute for Biometry and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.|Medical Faculty, Institute for Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors: O
authors: O
authors: Kuss
authors: Medical Faculty, Institute for Health and Nursing Science, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.|University Hospital Halle, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
authors: P
authors: P
authors: Jahn
mesh_terms: D000203:Activities of Daily Living; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D006304:Health Status; D018380:Hematopoietic Stem Cell Transplantation; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology; D009369:Neoplasms / Q000628:therapy*; D018529:Nutritional Support / Q000379:methods; D010348:Patient Care Team; D017060:Patient Satisfaction; D011446:Prospective Studies; D011788:Quality of Life; D000073278:Self-Management / Q000379:methods*; D013280:Stomatitis / Q000517:prevention & control; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: health-related quality of life; mucositis; physical activation; self-management; stem cell transplantation