title: Nanomaterial based electrochemical sensors for in vitro detection of small molecule metabolites.
abstract: Small molecule metabolites secreted by pathological processes can act as molecular biomarkers for clinical diagnosis. In vitro detection of the metabolites such as glucose and reactive oxygen species is of great significance for precise screening, monitoring and prognosis of metabolic disorders and relevant diseases such as cancer, and has been under intense research and development in clinical chemistry and molecular diagnostics. In this review, we summarize recent developments in nanomaterial based electrochemical (bio)sensors for in vitro detection of glucose and reactive oxygen species and the progress in utilizing lightweight and flexible electrodes and micro/nanoscale electrodes for flexible and miniaturized sensors.
authors: School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China; School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637457, Singapore.
authors: Fei
authors: F
authors: Xiao
authors: School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors: Lu
authors: L
authors: Wang
authors: School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637457, Singapore. Electronic address: hduan@ntu.edu.sg.
authors: Hongwei
authors: H
authors: Duan
mesh_terms: D015374:Biosensing Techniques; D003933:Diagnosis; D055664:Electrochemical Techniques / Q000295:instrumentation*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D049329:Nanostructures; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D005947:Glucose
keywords: Electrochemical (EC) sensors; Glucose sensor; In vitro diagnostics; Metabolic diseases; Nanomaterials (NMs); Reactive oxygen species