title: Comparison of adult stem cells derived from multiple stem cell niches.
abstract: OBJECTIVE
  Adult stem cells (ASCs) have great potential for tissue regeneration; however, comparative studies of ASCs from different niches are required to understand the characteristics of each population for their potential therapeutic uses.
  
  
  RESULTS
  We compared the proliferation, stem cell marker expression, and differentiation potential of ASCs from bone marrow, skin dermis, and adipose tissue. ASCs from bone marrow and skin dermis showed 50-100 % increased proliferation in comparison to the ASCs from adipose tissues. Furthermore, ASCs from each stem cell niche showed differential expression of stem cell marker genes, and preferentially differentiated into cell types of their tissue of origin.
  
  
  CONCLUSIONS
  Different characters of each ASC might be major factors for their effective use for therapeutics and tissue regeneration.
authors: Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors: Dong-Hun
authors: DH
authors: Woo
authors: Department of Oriental Cosmetic Science, Semyung University, Science & Engineering Bldg/Room 313, 65 Semyung-ro, Jecheon, Chungbuk, 390-711, Republic of Korea.
authors: Hyung Seo
authors: HS
authors: Hwang
authors: Department of Oriental Cosmetic Science, Semyung University, Science & Engineering Bldg/Room 313, 65 Semyung-ro, Jecheon, Chungbuk, 390-711, Republic of Korea. jhshim@semyung.ac.kr.
authors: Joong Hyun
authors: JH
authors: Shim
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D053687:Adult Stem Cells / Q000502:physiology*; D015415:Biomarkers / Q000032:analysis; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D049109:Cell Proliferation; D020405:Dermis / Q000166:cytology; D006801:Humans; D055153:Stem Cell Niche
chemical_list: D015415:Biomarkers
keywords: Adipose derived stem cells; Adult stem cells; Human dermal stem/progenitor cells; Mesenchymal stem cell; Multipotency