title: Prenatal exposure to ethinylestradiol alters the morphologic patterns and increases the predisposition for prostatic lesions in male and female gerbils during ageing.
abstract: Ethinylestradiol (EE) is an endocrine disruptor (ED) which acts as an oestrogen agonist; this compound is known as an oral contraceptive. Male and female rodents exposed to EE during critical time points of development, such as in the prenatal period, show alterations in their reproductive tract during adulthood. Few studies have placed an emphasis on the effects of EE during ageing. Thus, this study had as it's objective the analysis of the morphological and immunohistochemical effects of exposure to EE in the prenatal period on ventral male prostate and female prostate of gerbils (Meriones unguiculatus) during ageing. The animals were exposed to EE (15 μg/kg/day) during the 18-22th days of prenatal life (EE/PRE group), and the analyses were performed when the male and female reached 12 months of age. Our results showed an increase in the development of prostatic intraepithelial neoplasia (PIN), which was observed in the male and female prostate of EE/PRE groups. Immunohistochemistry showed a rise in prostatic epithelial and basal cells immunoreactivity, respectively, and to AR and p63 in the male EE/PRE. There were alterations in the morphological pattern of the prostatic glands and increase in predisposition to emergence of prostatic lesions of both sexes during ageing. Despite male and female having been exposed to the same doses of EE, the "exposure to EE promoted modifications" more accentuated in the male prostate. Thus the male gland is more sensitive to the action of this synthetic oestrogen than the female prostate.
authors: Department of Structural and Functional Biology, Institute of Biology, University of Campinas -UNICAMP, Campinas, São Paulo, Brazil.
authors: Ana P S
authors: AP
authors: Perez
authors: Department of Structural and Functional Biology, Institute of Biology, University of Campinas -UNICAMP, Campinas, São Paulo, Brazil.
authors: Manoel F
authors: MF
authors: Biancardi
authors: Department of Biology, Institute of Biosciences, Letters and Exact Sciences, São Paulo State University - IBILCE/UNESP, São José do Rio Preto, São Paulo, Brazil.
authors: Cássia R S
authors: CR
authors: Caires
authors: Department of Biology, Institute of Biosciences, Letters and Exact Sciences, São Paulo State University - IBILCE/UNESP, São José do Rio Preto, São Paulo, Brazil.
authors: Luiz R
authors: LR
authors: Falleiros-Junior
authors: Department of Structural and Functional Biology, Institute of Biology, University of Campinas -UNICAMP, Campinas, São Paulo, Brazil.|Department of Biology, Institute of Biosciences, Letters and Exact Sciences, São Paulo State University - IBILCE/UNESP, São José do Rio Preto, São Paulo, Brazil.
authors: Rejane M
authors: RM
authors: Góes
authors: Department of Biology, Institute of Biosciences, Letters and Exact Sciences, São Paulo State University - IBILCE/UNESP, São José do Rio Preto, São Paulo, Brazil.
authors: Patricia S L
authors: PS
authors: Vilamaior
authors: Department of Morphology, Federal University of Goiás - UFG, Goiânia, Goiás, Brazil.
authors: Fernanda C A
authors: FC
authors: Santos
authors: Department of Structural and Functional Biology, Institute of Biology, University of Campinas -UNICAMP, Campinas, São Paulo, Brazil.|Department of Biology, Institute of Biosciences, Letters and Exact Sciences, São Paulo State University - IBILCE/UNESP, São José do Rio Preto, São Paulo, Brazil.
authors: Sebastião R
authors: SR
authors: Taboga
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D004198:Disease Susceptibility / Q000196:embryology* / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D005849:Gerbillinae / Q000254:growth & development; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology*; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism; D019048:Prostatic Intraepithelial Neoplasia / Q000378:metabolism / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D011944:Receptors, Androgen / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism / Q000494:pharmacology
chemical_list: D011944:Receptors, Androgen; D013739:Testosterone; D004997:Ethinyl Estradiol; D004958:Estradiol
keywords: ageing; ethinylestradiol; female prostate; male prostate; prenatal period