title: Comparison of the six-minute walk test with a cycle-based cardiopulmonary exercise test in people following curative intent treatment for non-small cell lung cancer.
abstract: This study is aimed to (i) compare both the magnitude of impairment in exercise capacity and exercise responses measured during the six-minute walk test (6MWT) and the cardiopulmonary exercise test (CPET) and (ii) investigate the effect of test repetition on six-minute walk distance (6MWD) in people following curative intent treatment for non-small cell lung cancer (NSCLC). Twenty participants (67 ± 10 years; 14 females), 6-10 weeks following lobectomy, underwent a CPET and two 6MWTs. Peak exercise responses, dyspnoea and leg fatigue, as well as heart rate (HR) and oxygen saturation (SpO2) during the 6MWT, were compared to those during the CPET. Compared with exercise capacity when expressed as peak rate of oxygen consumption (%pred) measured during the CPET, exercise capacity when expressed as 6MWD (%pred) was less impaired (81 ± 10 vs. 63 ± 15 %pred; p < 0.001). Compared with the CPET, the 6MWT elicited lower peak HR (119 ± 15 vs. 128 ± 18 beats minute(-1); p = 0.02), lower SpO2 (93 ± 2 vs. 95 ± 3%; p < 0.05), less dyspnoea (3.1 ± 1.6 vs. 6.9 ± 2.6; p < 0.01) and less leg fatigue (2.0 ± 1.9 vs. 6.8 ± 2.4; p < 0.01). The 6MWD increased 19 ± 19 metre (4 ± 4%) with test repetition (p < 0.001). In people following curative intent treatment for NSCLC, the 6MWT appears to elicit sub-maximal exercise responses when compared with the CPET. There is a significant effect of test repetition on 6MWD.
authors: Faculty of Health Sciences, School of Physiotherapy and Exercise Science, Curtin University, Perth, WA, Australia Institute for Respiratory Health, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
authors: Vinicius
authors: V
authors: Cavalheri
authors: Faculty of Health Sciences, School of Physiotherapy and Exercise Science, Curtin University, Perth, WA, Australia Institute for Respiratory Health, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia Physiotherapy Department, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia, Australia.
authors: Sue
authors: S
authors: Jenkins
authors: Institute for Respiratory Health, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia Physiotherapy Department, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia, Australia Community Physiotherapy Services, Perth, Western Australia, Australia.
authors: Nola
authors: N
authors: Cecins
authors: Department of Respiratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
authors: Kevin
authors: K
authors: Gain
authors: Faculty of Health Sciences, School of Physiotherapy and Exercise Science, Curtin University, Perth, WA, Australia Institute for Respiratory Health, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia Physiotherapy Department, Royal Perth Hospital, Perth, Western Australia, Australia k.hill@curtin.edu.au.
authors: Kylie
authors: K
authors: Hill
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000601:surgery*; D003430:Cross-Sectional Studies; D004417:Dyspnea; D005080:Exercise Test; D017079:Exercise Tolerance; D005221:Fatigue; D005260:Female; D006339:Heart Rate; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010101:Oxygen Consumption; D011013:Pneumonectomy; D011184:Postoperative Period; D000070857:Walk Test
keywords: Exercise test; carcinoma; exercise tolerance; non-small cell