title: Insulin-Like Growth Factor-1 Levels in Term Newborns with Hypoxic-Ischemic Encephalopathy.
abstract: Objective This study aims to evaluate the correlation of changes in serum insulin-like growth factor-1 (IGF-1) levels with the clinical staging of hypoxic-ischemic encephalopathy (HIE) in term newborns. Study Design A prospective study of 29 newborns with HIE (stage I = 15, stage II + III = 14) and 28 healthy term newborns as the control group was performed in the neonatal intensive care unit. IGF-1 levels were obtained within 6 hours after birth from HIE and control groups and again on day 3 from HIE group. HIE was classified using the Sarnat staging I to III. Results IGF-1 levels were significantly lower in the HIE group than in the control group (p = 0.024). It was lower in the HIE stage II to III group compared with HIE stage I group at birth (p < 0.0001) and on day 3 (p = 0.009). The mean IGF-1 levels were significantly higher on day 3 than on day 1 among stage II to III HIE (p = 0.006) and it was inversely correlated with staging (R =  - 0.475, p = 0.009). There was a significant correlation between IGF-1 levels and Apgar score at 5 (R = 0.39, p = 0.042) and 10 minutes (R = 0.38, p = 0.035). Conclusions IGF-1 was lower in HIE and inversely correlated with clinical staging. It was increased with clinical improvement in the subsequent days.
authors: Department of Pediatrics, College of Medicine, University of Kufa, Al-Zahraa Teaching Hospital, Najaf Health Directorate, Najaf, Iraq.
authors: Raid M R
authors: RM
authors: Umran
authors: Najaf Health Directorate, Al-Zahraa Teaching Hospital, Najaf, Iraq.
authors: Mahir
authors: M
authors: Al-Tahir
authors: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Hospital of Michigan/Hutzel Women Hospital, Detroit.
authors: Desai
authors: D
authors: Jagdish
authors: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Hospital of Michigan/Hutzel Women Hospital, Detroit.
authors: Nitin
authors: N
authors: Chouthai
mesh_terms: D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000150:complications*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood*; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007493:Iraq; D008297:Male; D011446:Prospective Studies; D047929:Term Birth / Q000097:blood*
chemical_list: D007334:Insulin-Like Growth Factor I