title: Standardized Uptake Values from PET/MRI in Metastatic Breast Cancer: An Organ-based Comparison With PET/CT.
abstract: Quantitative standardized uptake values (SUVs) from fluorine-18 (18F) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) are commonly used to evaluate the extent of disease and response to treatment in breast cancer patients. Recently, PET/magnetic resonance imaging (MRI) has been shown to qualitatively detect metastases from various primary cancers with similar sensitivity to PET/CT. However, quantitative validation of PET/MRI requires assessing the reliability of SUVs from MR attenuation correction (MRAC) relative to CT attenuation correction (CTAC). The purpose of this retrospective study was to assess the utility of PET/MRI-derived SUVs in breast cancer patients by testing the hypothesis that SUVs derived from MRAC correlate well with those from CTAC. Between August 2012 and May 2013, 35 breast cancer patients (age 37-78 years, 1 man) underwent clinical 18F-FDG PET/CT followed by PET/MRI. One hundred seventy metastases were seen in 21 of 35 patients; metastases to bone in 16 patients, to liver in seven patients, and to nonaxillary lymph nodes in eight patients were sufficient for statistical analysis on an organ-specific per patient basis. SUVs in the most FDG-avid metastasis per organ per patient from PET/CT and PET/MRI were measured and compared using Pearson's correlations. Correlations between CTAC- and MRAC-derived SUVmax and SUVmean in 31 metastases to bone, liver, and nonaxillary lymph nodes were strong overall (ρ = 0.80, 0.81). SUVmax and SUVmean correlations were also strong on an organ-specific basis in 16 bone metastases (ρ = 0.76, 0.74), seven liver metastases (ρ = 0.85, 0.83), and eight nonaxillary lymph node metastases (ρ = 0.95, 0.91). These strong organ-specific correlations between SUVs from PET/CT and PET/MRI in breast cancer metastases support the use of SUVs from PET/MRI for quantitation of 18F-FDG activity.
authors: Department of Radiology, New York University School of Medicine, New York, New York.
authors: Akshat C
authors: AC
authors: Pujara
authors: Department of Radiology, New York University School of Medicine, New York, New York.|Nuclear Medicine Section, New York University School of Medicine, New York, New York.
authors: Roy A
authors: RA
authors: Raad
authors: Department of Radiology, New York University School of Medicine, New York, New York.|Nuclear Medicine Section, New York University School of Medicine, New York, New York.
authors: Fabio
authors: F
authors: Ponzo
authors: Department of Radiology, New York University School of Medicine, New York, New York.|Breast Imaging Section, New York University School of Medicine, New York, New York.
authors: Carolyn
authors: C
authors: Wassong
authors: Department of Radiology, New York University School of Medicine, New York, New York.|Center for Advanced Imaging Innovation and Research (CAI(2)R), NYU Department of Radiology, New York, New York.
authors: James S
authors: JS
authors: Babb
authors: Department of Radiology, New York University School of Medicine, New York, New York.|Breast Imaging Section, New York University School of Medicine, New York, New York.|Center for Advanced Imaging Innovation and Research (CAI(2)R), NYU Department of Radiology, New York, New York.
authors: Linda
authors: L
authors: Moy
authors: Department of Radiology, New York University School of Medicine, New York, New York.|Breast Imaging Section, New York University School of Medicine, New York, New York.|Center for Advanced Imaging Innovation and Research (CAI(2)R), NYU Department of Radiology, New York, New York.
authors: Amy N
authors: AN
authors: Melsaether
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D018567:Breast Neoplasms, Male / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008099:Liver / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods / Q000592:standards*; D012189:Retrospective Studies
keywords: PET/MRI; SUV; attenuation correction; breast cancer; hybrid imaging