title: Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria.
abstract: Expression of certain bacterial genes only at a high bacterial cell density is termed as quorum-sensing (QS). Here bacteria use signaling molecules to communicate among themselves. QS mediated genes are generally involved in the expression of phenotypes such as bioluminescence, biofilm formation, competence, nodulation, and virulence. QS systems (QSS) vary from a single in Vibrio spp. to multiple in Pseudomonas and Sinorhizobium species. The complexity of QSS is further enhanced by the multiplicity of signals: (1) peptides, (2) acyl-homoserine lactones, (3) diketopiperazines. To counteract this pathogenic behaviour, a wide range of bioactive molecules acting as QS inhibitors (QSIs) have been elucidated. Unlike antibiotics, QSIs don't kill bacteria and act at much lower concentration than those of antibiotics. Bacterial ability to evolve resistance against multiple drugs has cautioned researchers to develop QSIs which may not generate undue pressure on bacteria to develop resistance against them. In this paper, we have discussed the implications of the diversity and multiplicity of QSS, in acting as an arsenal to withstand attack from QSIs and may use these as reservoirs to develop multi-QSI resistance.
authors: Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007 India ; Academy for Scientific and Innovative Research (AcSIR), 2 Rafi Marg, New Delhi, 110001 India.
authors: Shikha
authors: S
authors: Koul
authors: Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007 India ; Academy for Scientific and Innovative Research (AcSIR), 2 Rafi Marg, New Delhi, 110001 India.
authors: Jyotsana
authors: J
authors: Prakash
authors: Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007 India.
authors: Anjali
authors: A
authors: Mishra
authors: Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007 India ; Academy for Scientific and Innovative Research (AcSIR), 2 Rafi Marg, New Delhi, 110001 India.
authors: Vipin Chandra
authors: VC
authors: Kalia
keywords: Antibiotics; Bioactive molecules; Drug resistance; Quorum-sensing; Quorum-sensing inhibitors