title: pH-Triggered Charge-Reversal Polyurethane Micelles for Controlled Release of Doxorubicin.
abstract: A series of pH-triggered charge-reversal polyurethane copolymers (PS-PUs) containing methoxyl-poly(ethylene glycol) (mPEG), carboxylic acid groups, and piperazine groups is presented in this work. The obtained PS-PUs copolymers can form into stable micelles at pH 7.4, which response to a narrow pH change (5.5-7.5) and show a tunable pH-triggered charge-reversal property. Doxorubicin (DOX) is encapsulated into the PS-PU micelles as a model drug. The drug release of DOX-loaded PS-PU micelles shows an obviously stepped-up with reducing the pH. Meanwhile, it is found that the charge-reversal property can improve the cellular uptake behavior and intracellular drug release in both HeLa cells and MCF-7 cells. Additionally, the time-dependent cytotoxicity of the DOX-loaded PS-PU micelles is confirmed by MTT assay. Attributed to the tunable charge-reversal property through changing the molar ratio of piperazine/carboxyl, the PS-PU micelles will be a potential candidate as an intelligent drug delivery system in future studies.
authors: School of Chemical Engineering, School of Chemistry and Life Science, Changchun University of Technology, Changchun, 130012, P. R. China.
authors: Wanying
authors: W
authors: He
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
authors: Xu
authors: X
authors: Zheng
authors: School of Chemical Engineering, School of Chemistry and Life Science, Changchun University of Technology, Changchun, 130012, P. R. China.
authors: Qi
authors: Q
authors: Zhao
authors: School of Chemical Engineering, School of Chemistry and Life Science, Changchun University of Technology, Changchun, 130012, P. R. China.|Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
authors: Lijie
authors: L
authors: Duan
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
authors: Qiang
authors: Q
authors: Lv
authors: School of Chemical Engineering, School of Chemistry and Life Science, Changchun University of Technology, Changchun, 130012, P. R. China.
authors: Guang Hui
authors: GH
authors: Gao
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
authors: Shuangjiang
authors: S
authors: Yu
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005260:Female; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D008823:Micelles; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: charge reversal; drug delivery; pH-responsive; polyurethane nanocarrier