title: Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs).
abstract: Extracorporeal shock wave therapy (ESWT) is a non-invasive and innovative technology for the management of specific tendinopathies. In order to elucidate the ESWT-mediated clinical benefits, human Tendon-derived Stem/Progenitor cells (hTSPCs) explanted from 5 healthy semitendinosus (ST) and 5 ruptured Achilles (AT) tendons were established. While hTSPCs from the two groups showed similar proliferation rates and stem cell surface marker profiles, we found that the clonogenic potential was maintained only in cells derived from healthy donors. Interestingly, ESWT significantly accelerated hTSPCs differentiation, suggesting that the clinical benefits of ESWT may be ascribed to increased efficiency of tendon repair after injury.
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
authors: Laura
authors: L
authors: Leone
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.|Cellular Diagnostics Unit, Sant'Andrea Hospital, Rome, Italy.
authors: Salvatore
authors: S
authors: Raffa
authors: Department of Orthopedics and Traumatology, Sant'Andrea Hospital, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
authors: Mario
authors: M
authors: Vetrano
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
authors: Danilo
authors: D
authors: Ranieri
authors: Department of Biomedicine and Prevention, Laboratory of Signal Transduction, "Tor Vergata" University of Rome, Rome, Italy.
authors: Florence
authors: F
authors: Malisan
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
authors: Cristina
authors: C
authors: Scrofani
authors: Department of Orthopedics and Traumatology, Sant'Andrea Hospital, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
authors: Maria Chiara
authors: MC
authors: Vulpiani
authors: Department of Orthopedics and Traumatology, Sant'Andrea Hospital, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
authors: Andrea
authors: A
authors: Ferretti
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.|Cellular Diagnostics Unit, Sant'Andrea Hospital, Rome, Italy.
authors: Maria Rosaria
authors: MR
authors: Torrisi
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.|Cellular Diagnostics Unit, Sant'Andrea Hospital, Rome, Italy.
authors: Vincenzo
authors: V
authors: Visco
mesh_terms: D050156:Adipogenesis / Q000528:radiation effects; D002454:Cell Differentiation / Q000502:physiology* / Q000528:radiation effects; D049109:Cell Proliferation / Q000502:physiology* / Q000528:radiation effects; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D019220:High-Energy Shock Waves; D006801:Humans; D066298:In Vitro Techniques; D010012:Osteogenesis / Q000528:radiation effects; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology / Q000528:radiation effects; D013708:Tendon Injuries / Q000473:pathology* / Q000532:radiotherapy; D013710:Tendons / Q000166:cytology* / Q000502:physiology / Q000528:radiation effects
keywords: ESWT; Pathology Section; differentiation; healing; stem cells; tendon