title: Self-Healing Spongy Coating for Drug "Cocktail" Delivery.
abstract: Optimized ratio in the codelivery of therapeutics is of crucial importance to promote the synergism rather than the antagonistic effects. In this study, a self-healing spongy coating was described to facilitate the surface-mediated delivery of drug "cocktails" proportionally. The formation of spongy structures within the coating was achieved by acidic treatment and freeze-drying. Various drug combinations can be readily integrated through wicking method and subsequent micropore self-healing. The ratio of drug loading can be precisely regulated by the composition of loading solution and the embedded drugs were released in proportion according to the initial ratio of drug combination.
authors: MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University , Hangzhou 310027, China.
authors: Xia-chao
authors: XC
authors: Chen
authors: MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University , Hangzhou 310027, China.
authors: Ke-feng
authors: KF
authors: Ren
authors: MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University , Hangzhou 310027, China.
authors: Wen-xi
authors: WX
authors: Lei
authors: MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University , Hangzhou 310027, China.
authors: Jia-hui
authors: JH
authors: Zhang
authors: i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto 4200-135, Portugal.|INEB-Instituto de Engenharia Biomédica, Universidade do Porto , Rua do Campo Alegre, 823, Porto 4150-180, Portugal.|ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto , Porto 4050-313, Portugal.
authors: M Cristina L
authors: MC
authors: Martins
authors: INEB-Instituto de Engenharia Biomédica, Universidade do Porto , Rua do Campo Alegre, 823, Porto 4150-180, Portugal.|ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto , Porto 4050-313, Portugal.
authors: Mário A
authors: MA
authors: Barbosa
authors: MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University , Hangzhou 310027, China.
authors: Jian
authors: J
authors: Ji
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004357:Drug Synergism; D006801:Humans; D000071228:Polyelectrolytes / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry; D013499:Surface Properties; D014945:Wound Healing
chemical_list: D000180:Acrylic Resins; D000071228:Polyelectrolytes; C006903:carbopol 940; D011094:Polyethyleneimine
keywords: drug combination; polyelectrolyte multilayers; proportional codelivery; self-healing; spongy coating