title: Strategies for construction of the all-carbon macrocyclic skeleton of the ansamycin antibiotic-kendomycin.
abstract: Kendomycin, an ansamycin-type natural product first reported in 1996, possesses a series of attractive bioactivities and a unique all-carbon macrocyclic skeleton. To the date, seven total syntheses, two formal total syntheses and a number of synthetic studies on this hot molecule have been reported. In this short review article, we mainly survey and comment on these efforts regarding the difficult macrocyclization strategies.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.|Department of Medicinal Chemistry, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
authors: Shu
authors: S
authors: Xu
authors: Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
authors: Hirokazu
authors: H
authors: Arimoto
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D006801:Humans; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis*; D017828:Rifabutin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D013302:Streptomyces / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D047029:Lactams, Macrocyclic; C485395:kendomycin; D017828:Rifabutin