title: Cost-effectiveness analysis of febuxostat in patients with gout in Spain.
abstract: Objectives Cost-effectiveness of febuxostat compared with allopurinol in the treatment of hyperuricemia in patients with gout. Methods Costs, clinical outcomes, and QALYs were estimated using a Markov model. Febuxostat 80 mg and 120 mg sequentially, used as first line and second line therapy, was compared with allopurinol 300 mg. Patients switched to the next treatment in the sequence according to a dichotomous response vs no response (target serum urate level < 6 mg/dl outcome) after 3 months of active treatment. A 3% discount rate and 5-year time horizon were applied.
  
  
  CONCLUSIONS
  National Health System. Results The addition of febuxostat to any therapeutic strategy was an efficient option, with incremental cost-effectiveness ratios (ICER) compared with allopurinol 300 mg ranging from €5268-€9737. Conclusions Febuxostat is a cost-effective treatment in Spain for the management of hyperuricemia in gout patients, with ICERs far below accepted Spanish efficiency thresholds (30 000€/QALY).
authors: a Rheumatology Division , Hospital Universitario Cruces and BioCruces Health Research Institute , Baracaldo , Spain ;
authors: F
authors: F
authors: Perez-Ruiz
authors: b Rheumatology Unit , Internal Medicine Department Hospital Sant Pau , Barcelona , Spain ;
authors: C
authors: C
authors: Díaz-Torné
authors: c Oblikue Consulting , Barcelona , Spain.
authors: D
authors: D
authors: Carcedo
mesh_terms: D000493:Allopurinol / Q000191:economics* / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D004305:Dose-Response Relationship, Drug; D000069465:Febuxostat / Q000191:economics* / Q000627:therapeutic use; D006073:Gout / Q000188:drug therapy*; D006074:Gout Suppressants / Q000191:economics* / Q000627:therapeutic use; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy*; D008390:Markov Chains; D017059:Models, Econometric; D019057:Quality-Adjusted Life Years; D016032:Randomized Controlled Trials as Topic; D051437:Renal Insufficiency / Q000453:epidemiology; D013030:Spain
chemical_list: D006074:Gout Suppressants; D000069465:Febuxostat; D000493:Allopurinol
keywords: Allopurinol; Cost; Cost-effectiveness; Febuxostat; Gout; Spain