title: Natural fatty acid synthase inhibitors as potent therapeutic agents for cancers: A review.
abstract: Context Fatty acid synthase (FAS) is the only mammalian enzyme to catalyse the synthesis of fatty acid. The expression level of FAS is related to cancer progression, aggressiveness and metastasis. In recent years, research on natural FAS inhibitors with significant bioactivities and low side effects has increasingly become a new trend. Herein, we present recent research progress on natural fatty acid synthase inhibitors as potent therapeutic agents. Objective This paper is a mini overview of the typical natural FAS inhibitors and their possible mechanism of action in the past 10 years (2004-2014). Method The information was collected and compiled through major databases including Web of Science, PubMed, and CNKI. Results Many natural products induce cancer cells apoptosis by inhibiting FAS expression, with fewer side effects than synthetic inhibitors. Conclusion Natural FAS inhibitors are widely distributed in plants (especially in herbs and foods). Some natural products (mainly phenolics) possessing potent biological activities and stable structures are available as lead compounds to synthesise promising FAS inhibitors.
authors: a School of Life Science and Engineering, Southwest Jiaotong University , Chengdu , China ;
authors: Jia-Sui
authors: JS
authors: Zhang
authors: a School of Life Science and Engineering, Southwest Jiaotong University , Chengdu , China ;
authors: Jie-Ping
authors: JP
authors: Lei
authors: a School of Life Science and Engineering, Southwest Jiaotong University , Chengdu , China ;
authors: Guo-Qing
authors: GQ
authors: Wei
authors: a School of Life Science and Engineering, Southwest Jiaotong University , Chengdu , China ;
authors: Hui
authors: H
authors: Chen
authors: a School of Life Science and Engineering, Southwest Jiaotong University , Chengdu , China ;|b School of Medicine, Southwest Jiaotong University , Chengdu , China.
authors: Chao-Ying
authors: CY
authors: Ma
authors: a School of Life Science and Engineering, Southwest Jiaotong University , Chengdu , China ;
authors: He-Zhong
authors: HZ
authors: Jiang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D054872:Fatty Acid Synthesis Inhibitors / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008517:Phytotherapy; D010946:Plants, Medicinal; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D054872:Fatty Acid Synthesis Inhibitors; D064429:Fatty Acid Synthases
keywords: Antitumour; mechanism of action; natural FAS inhibitors; phenolics