title: Complete genome sequence of Streptomyces globisporus C-1027, the producer of an enediyne antibiotic lidamycin.
abstract: Streptomyces globisporus C-1027 produces a nine-membered enediyne antitumor antibiotic lidamycin. Here we report the complete genome sequence of S. globisporus C-1027, which consists of a 7,608,611 bp linear chromosome, a 167,754 bp linear plasmid SGLP1 and a 7,234 bp circular plasmid pSGL1. The biosynthetic gene cluster for lidamycin was located in the linear plasmid SGLP1. Genome analysis also revealed a number of genes related to biosynthesis of diverse secondary metabolites. The genome sequence of C-1027 will enable us to disclose biosynthetic pathways of these secondary metabolites and discover new natural products with potential applications notably in human health.
authors: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Xingxing
authors: X
authors: Li
authors: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Xuan
authors: X
authors: Lei
authors: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Cong
authors: C
authors: Zhang
authors: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Zhibo
authors: Z
authors: Jiang
authors: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Yuanyuan
authors: Y
authors: Shi
authors: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Songmei
authors: S
authors: Wang
authors: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: lifeiwang2002@hotmail.com.
authors: Lifei
authors: L
authors: Wang
authors: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: binhong69@hotmail.com.
authors: Bin
authors: B
authors: Hong
mesh_terms: D000617:Aminoglycosides; D053281:Enediynes; D016680:Genome, Bacterial / Q000235:genetics*; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D053281:Enediynes; C058024:C 1027
keywords: Genome sequence; Lidamycin; Streptomyces globisporus C-1027