title: Perinatal air pollution exposure and development of asthma from birth to age 10 years.
abstract: Within-city variation in air pollution has been associated with childhood asthma development, but findings have been inconsistent. We examined whether perinatal air pollution exposure affected asthma onset during "pre-school and "school age" periods in a population-based birth cohort.65,254 children born between 1999 and 2002 in the greater Vancouver metropolitan region were followed until age 10 years using linked administrative health databases. Asthma cases were sex- and age-matched to five randomly chosen controls. Associations between exposure to air pollutants estimated with different methods (interpolation (inverse-distance weighted (IDW)), land use regression, proximity) and incident asthma during the pre-school (0-5 years) and school age (6-10 years) periods were estimated with conditional logistic regression.6948 and 1711 cases were identified during the pre-school and school age periods, respectively. Following adjustment for birthweight, gestational period, household income, parity, breastfeeding at discharge, maternal age and education, asthma risk during the pre-school years was increased by traffic pollution (adjusted odds ratio using IDW method per interquartile increase (95% CI): nitric oxide 1.06 (1.01-1.11), nitrogen dioxide 1.09 (1.04-1.13) and carbon monoxide 1.05 (1.01-1.1)). Enhanced impacts were observed amongst low-term-birthweight cases. Associations were independent of surrounding residential greenness.Within-city air pollution variation was associated with new asthma onset during the pre-school years.
authors: School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada hind.sbihi@ubc.ca.
authors: Hind
authors: http://orcid.org/0000-0002-4288-7258
authors: H
authors: Sbihi
authors: School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
authors: Lillian
authors: L
authors: Tamburic
authors: School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
authors: Mieke
authors: M
authors: Koehoorn
authors: School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
authors: Michael
authors: M
authors: Brauer
mesh_terms: D000393:Air Pollutants / Q000032:analysis*; D000397:Air Pollution / Q000009:adverse effects*; D001249:Asthma / Q000175:diagnosis* / Q000209:etiology*; D001955:British Columbia; D002248:Carbon Monoxide / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D009569:Nitric Oxide / Q000032:analysis; D009585:Nitrogen Dioxide / Q000032:analysis; D016017:Odds Ratio; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D000393:Air Pollutants; D009569:Nitric Oxide; D002248:Carbon Monoxide; D009585:Nitrogen Dioxide