title: Accuracy of myocardial perfusion imaging in detecting multivessel coronary artery disease: A cardiac CZT study.
abstract: Myocardial perfusion imaging (MPI) performed on traditional single-photon emission computed-tomography cameras has been shown to have a sub-optimal accuracy in detecting multivessel coronary artery disease (CAD).
  
  
  
  Six-hundred and ninety-five patients were submitted to MPI on a novel cadmium-zinc-telluride (CZT) camera and coronary angiography. A coronary stenosis >70% was considered obstructive. In every patient, the summed stress score (SSS) was computed. Moreover, the regional stress scores were also calculated for every coronary territory.
  
  
  
  Four-hundred and forty-one patients had obstructive CAD in one (28%), two (19%), or three (17%) vessels. At per-patient analysis, the SSS showed a significant accuracy in detecting obstructive CAD (AUC 0.87, P < .001). Specifically, its accuracy was maintained also in patients with double (AUC 0.83; P < .001) or triple-vessels disease (AUC 0.79, P < .001), where CZT was able to correctly identify CAD extent in 64% of patients. On a per-vessel basis, CZT confirmed its high accuracy in detecting obstructive CAD (AUC 0.88, P < .001), independently from the involved coronary vessel.
  
  
  
  MPI performed on a CZT camera is highly accurate in detecting obstructive CAD, independently from the coronary artery involved and the overall disease burden.
authors: Fondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124, Pisa, Italy.
authors: Alessia
authors: A
authors: Gimelli
authors: Cardio-thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy. riccardo.liga@gmail.com.
authors: Riccardo
authors: R
authors: Liga
authors: Cardio-thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy.
authors: Valerio
authors: V
authors: Duce
authors: Fondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124, Pisa, Italy.
authors: Annette
authors: A
authors: Kusch
authors: Fondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124, Pisa, Italy.
authors: Alberto
authors: A
authors: Clemente
authors: Fondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124, Pisa, Italy.|CNR, Institute of Clinical Physiology, Pisa, Italy.
authors: Paolo
authors: P
authors: Marzullo
mesh_terms: D000368:Aged; D002104:Cadmium; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011877:Radionuclide Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013691:Tellurium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D015032:Zinc
chemical_list: C474490:CdZnTe; D002104:Cadmium; D015032:Zinc; D013691:Tellurium
keywords: Myocardial perfusion imaging; cadmium-zinc-telluride; coronary artery disease; multivessel disease; myocardial ischemia