title: Enzymes of yeast polyphosphate metabolism: structure, enzymology and biological roles.
abstract: Inorganic polyphosphate (polyP) is found in all living organisms. The known polyP functions in eukaryotes range from osmoregulation and virulence in parasitic protozoa to modulating blood coagulation, inflammation, bone mineralization and cellular signalling in mammals. However mechanisms of regulation and even the identity of involved proteins in many cases remain obscure. Most of the insights obtained so far stem from studies in the yeast Saccharomyces cerevisiae. Here, we provide a short overview of the properties and functions of known yeast polyP metabolism enzymes and discuss future directions for polyP research.
authors: Department of Biochemistry, University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, Switzerland.
authors: Rūta
authors: R
authors: Gerasimaitė
authors: Department of Biochemistry, University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, Switzerland andreas.mayer@unil.ch.
authors: Andreas
authors: A
authors: Mayer
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000737:chemistry* / Q000378:metabolism*; D011122:Polyphosphates / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology*
chemical_list: D011122:Polyphosphates; D017766:Acid Anhydride Hydrolases; C022563:endopolyphosphatase
keywords: endopolyphosphatase; exopolyphosphatase; inorganic polyphosphate; polyP polymerase; vacuolar transporter chaperone (VTC) complex; yeast vacuole