title: GMOL: An Interactive Tool for 3D Genome Structure Visualization.
abstract: It has been shown that genome spatial structures largely affect both genome activity and DNA function. Knowing this, many researchers are currently attempting to accurately model genome structures. Despite these increased efforts there still exists a shortage of tools dedicated to visualizing the genome. Creating a tool that can accurately visualize the genome can aid researchers by highlighting structural relationships that may not be obvious when examining the sequence information alone. Here we present a desktop application, known as GMOL, designed to effectively visualize genome structures so that researchers may better analyze genomic data. GMOL was developed based upon our multi-scale approach that allows a user to scale between six separate levels within the genome. With GMOL, a user can choose any unit at any scale and scale it up or down to visualize its structure and retrieve corresponding genome sequences. Users can also interactively manipulate and measure the whole genome structure and extract static images and machine-readable data files in PDB format from the multi-scale structure. By using GMOL researchers will be able to better understand and analyze genome structure models and the impact their structural relations have on genome activity and DNA function.
authors: Computer Science Department, University of Missouri, Columbia, MO 65211, USA.
authors: Jackson
authors: J
authors: Nowotny
authors: Computer Science Department, University of Missouri, Columbia, MO 65211, USA.
authors: Avery
authors: A
authors: Wells
authors: Computer Science Department, University of Missouri, Columbia, MO 65211, USA.
authors: Oluwatosin
authors: O
authors: Oluwadare
authors: Computer Science Department, University of Missouri, Columbia, MO 65211, USA.
authors: Lingfei
authors: L
authors: Xu
authors: Computer Science Department, University of Missouri, Columbia, MO 65211, USA.
authors: Renzhi
authors: R
authors: Cao
authors: Computer Science Department, University of Missouri, Columbia, MO 65211, USA.
authors: Tuan
authors: T
authors: Trieu
authors: Computer Science Department, University of Missouri, Columbia, MO 65211, USA.
authors: Chenfeng
authors: C
authors: He
authors: Computer Science Department, University of Missouri, Columbia, MO 65211, USA.|Informatics Institute, University of Missouri, Columbia, MO 65211, USA.|C.S. Bond Life Science Center, University of Missouri, Columbia, MO 65211, USA.
authors: Jianlin
authors: J
authors: Cheng
mesh_terms: D002877:Chromosomes, Human / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D021621:Imaging, Three-Dimensional; D012984:Software