title: The Geisinger MyCode community health initiative: an electronic health record-linked biobank for precision medicine research.
abstract: Geisinger Health System (GHS) provides an ideal platform for Precision Medicine. Key elements are the integrated health system, stable patient population, and electronic health record (EHR) infrastructure. In 2007, Geisinger launched MyCode, a system-wide biobanking program to link samples and EHR data for broad research use.
  
  
  
  Patient-centered input into MyCode was obtained using participant focus groups. Participation in MyCode is based on opt-in informed consent and allows recontact, which facilitates collection of data not in the EHR and, since 2013, the return of clinically actionable results to participants. MyCode leverages Geisinger's technology and clinical infrastructure for participant tracking and sample collection.
  
  
  
  MyCode has a consent rate of >85%, with more than 90,000 participants currently and with ongoing enrollment of ~4,000 per month. MyCode samples have been used to generate molecular data, including high-density genotype and exome sequence data. Genotype and EHR-derived phenotype data replicate previously reported genetic associations.
  
  
  
  The MyCode project has created resources that enable a new model for translational research that is faster, more flexible, and more cost-effective than traditional clinical research approaches. The new model is scalable and will increase in value as these resources grow and are adopted across multiple research platforms.Genet Med 18 9, 906-913.
authors: Geisinger Health System, Danville, PA, USA.
authors: David J
authors: 0000-0001-6404-1950
authors: DJ
authors: Carey
authors: Geisinger Health System, Danville, PA, USA.
authors: Samantha N
authors: SN
authors: Fetterolf
authors: Geisinger Health System, Danville, PA, USA.
authors: F Daniel
authors: FD
authors: Davis
authors: Geisinger Health System, Danville, PA, USA.
authors: William A
authors: 0000-0003-3051-3256
authors: WA
authors: Faucett
authors: Geisinger Health System, Danville, PA, USA.
authors: H Lester
authors: HL
authors: Kirchner
authors: Geisinger Health System, Danville, PA, USA.
authors: Uyenlinh
authors: U
authors: Mirshahi
authors: Geisinger Health System, Danville, PA, USA.
authors: Michael F
authors: 0000-0001-8616-9138
authors: MF
authors: Murray
authors: Geisinger Health System, Danville, PA, USA.
authors: Diane T
authors: 0000-0002-3925-8864
authors: DT
authors: Smelser
authors: Current address: Department of Medical Genetics and Molecular Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA.
authors: Glenn S
authors: GS
authors: Gerhard
authors: Geisinger Health System, Danville, PA, USA.
authors: David H
authors: DH
authors: Ledbetter
mesh_terms: D018070:Biological Specimen Banks; D035843:Biomedical Research; D057286:Electronic Health Records; D005838:Genotype; D006801:Humans; D010641:Phenotype; D057285:Precision Medicine; D011634:Public Health