title: Stromal Cell-Derived Factor-1-3'A Polymorphism Favors HIV-1 Infection in Mexican Women.
abstract: OBJECTIVE
  To evaluate the association of the stromal cell-derived factor-1 (SDF1)-3'A polymorphism to HIV-1 infection, CD4+ T-lymphocyte counts, and viral load levels in a northwestern Mexican population.
  
  
  METHODS
  We investigated allele and genotype frequencies of the SDF1-3'A polymorphism in 634 mestizo individuals from Northwest Mexico (204 HIV-1 infected persons, 256 uninfected blood donors, and 174 uninfected female sex workers) by the PCR- RFLP method and compared them using a x(2) test. We also searched for correlations between the polymorphism and CD4+ T lymphocyte and viral load counts.
  
  
  RESULTS
  No differences were observed in the frequencies of alleles and genotypes between patients and controls. However, in female patients we found a significantly increased prevalence of both the A allele and GA heterozygous genotype compared to male patients, female blood donors, and female sex workers.
  
  
  CONCLUSIONS
  Here we describe the association of the SDF1-3'A polymorphism with HIV-1 infection only in women, but not to CD4+ T-lymphocyte categories, viral load levels in patients with HIV-1/AIDS, or to exposure levels in female sex workers.
authors: Centro de Medicina Genx00F3;mica, Hospital General de Culiacx00E1;n x2018;Dr. Bernardo J. Gastx00E9;lum', Servicios de Salud de Sinaloa, Culiacx00E1;n, Mexico.
authors: Jesús Salvador
authors: JS
authors: Velarde-Félix
authors: Silvestre Guadalupe
authors: SG
authors: Cázarez-Salazar
authors: Sylvia Páz
authors: SP
authors: Díaz-Camacho
authors: Ignacio
authors: I
authors: Osuna-Ramírez
authors: Luis Antonio
authors: LA
authors: Ochoa-Ramírez
authors: Jorge Guillermo
authors: JG
authors: Sánchez-Zazueta
authors: Martín
authors: M
authors: Ramírez
mesh_terms: D000483:Alleles; D015496:CD4-Positive T-Lymphocytes; D054377:Chemokine CXCL12 / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008800:Mexico; D011110:Polymorphism, Genetic / Q000235:genetics*; D012737:Sex Factors; D060386:Sex Workers; D019562:Viral Load
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12