title: Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice.
abstract: The plant Cocos nucifera and its derivatives have shown antidepressant-like effects, although its hydroalcoholic extract has not been studied with this end in mind. Therefore, we decided to determine the antidepressant-like effects of the standardized hydroalcoholic extract of Cocos nucifera husk fiber (HECN) as well as oxidative alterations in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST), and the levels of brain-derived neurotrophic factor (BDNF) in the HC of mice. The extract was characterized based on the content of total polyphenols as well as two phenol compounds-catechin and chlorogenic acid-by HPLC-PDA. Male animals were treated per os (p.o.) for 7 days with distilled water or HECN (50, 100 or 200 mg/kg), or intraperitoneally with vitamin E (Vit E 400 mg/kg). One hour after the last drug administration, the animals were submitted to the open field test, forced swimming test (FST), tail suspension test (TST) and, immediately after the behavioral tests, had their brain removed for neurochemical determinations. The results showed that HECN100 decreased the immobility time in the FST and TST presenting, thus demonstrating an antidepressant-like effect. The administration of HECN decreased malondialdehyde levels in all doses and brain areas studied with the exception of HECN50 in the HC. The administration of HECN also decreased nitrite levels in all doses and brain regions studied. HECN100 also increased the levels of BDNF in HC of mice. In conclusion, we demonstrated that HECN has antidepressant-like properties, probably based on its antioxidant and neurotrophic effects, and is thus relevant for the treatment of depression.
authors: Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, Fortaleza, Ceará, 60431-270, Brazil.
authors: Eliane Brito Cortez
authors: EB
authors: Lima
authors: Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, Fortaleza, Ceará, 60431-270, Brazil.
authors: Caren Nádia Soares
authors: CN
authors: de Sousa
authors: Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, Fortaleza, Ceará, 60431-270, Brazil.
authors: Germana Silva
authors: GS
authors: Vasconcelos
authors: Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, Fortaleza, Ceará, 60431-270, Brazil.
authors: Lucas Nascimento
authors: LN
authors: Meneses
authors: Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, Fortaleza, Ceará, 60431-270, Brazil.
authors: Yuri Freitas
authors: YF
authors: E Silva Pereira
authors: Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, Fortaleza, Ceará, 60431-270, Brazil.
authors: Naiara Coelho
authors: NC
authors: Ximenes
authors: Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, Fortaleza, Ceará, 60431-270, Brazil.
authors: Manuel Alves
authors: MA
authors: Santos Júnior
authors: Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, Fortaleza, Ceará, 60431-270, Brazil.
authors: Natália Castelo Branco
authors: NC
authors: Matos
authors: Center of Pharmaceutical and Cosmetic Studies, Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
authors: Rayanne
authors: R
authors: Brito
authors: Center of Pharmaceutical and Cosmetic Studies, Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
authors: Diogo
authors: D
authors: Miron
authors: Center of Pharmaceutical and Cosmetic Studies, Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
authors: Luzia Kalyne Almeida Moreira
authors: LK
authors: Leal
authors: Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, Fortaleza, Ceará, 60431-270, Brazil.
authors: Danielle
authors: D
authors: Macêdo
authors: Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, Fortaleza, Ceará, 60431-270, Brazil. silvania_vasconcelos@yahoo.com.br.
authors: Silvânia Maria Mendes
authors: SM
authors: Vasconcelos
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D003059:Cocos / Q000737:chemistry*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D000975:Antioxidants; D019208:Brain-Derived Neurotrophic Factor; D010936:Plant Extracts
keywords: BDNF; Behavioral test; Cocos nucifera; Oxidative stress; Phenols