title: Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis.
abstract: An asymmetric decarboxylative Csp(3)-Csp(2) cross-coupling has been achieved via the synergistic merger of photoredox and nickel catalysis. This mild, operationally simple protocol transforms a wide variety of naturally abundant α-amino acids and readily available aryl halides into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in pharmacologically active agents.
authors: Merck Center for Catalysis, Princeton University , Princeton, New Jersey 08544, United States.
authors: Zhiwei
authors: Z
authors: Zuo
authors: Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.
authors: Huan
authors: H
authors: Cong
authors: Merck Center for Catalysis, Princeton University , Princeton, New Jersey 08544, United States.
authors: Wei
authors: W
authors: Li
authors: Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.
authors: Junwon
authors: J
authors: Choi
authors: Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.
authors: Gregory C
authors: GC
authors: Fu
authors: Merck Center for Catalysis, Princeton University , Princeton, New Jersey 08544, United States.
authors: David W C
authors: DW
authors: MacMillan
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002264:Carboxylic Acids; D009532:Nickel