title: Relationship Between Buprenorphine Dosing and Triglyceride Lowering and creatine kinase [corrected]  Elevation in Felines: Possible Human Implications.
abstract: Recently published feline data suggest that high doses of buprenorphine can elevate creatine kinase (CK)  [corrected] and profoundly influence triglyceride levels in an inverted dose versus effect relationship. This intriguing observation in felines, hitherto not documented for buprenorphine, should be considered in human situations for any trends of translatability. The report evaluates the observed effects in domestic cats and what is known about buprenorphine in human subjects. Based on the objective assessment, the following are deduced: (a) although elevated CK levels is a nonissue in humans, one needs to pay attention especially when buprenorphine is used at the high end of therapeutic dose range in the presence of drugs that can impair the hepatic metabolism of buprenorphine; and (b) the potential for triglyceride lowering can be easily confirmed in human trials, and since it may occur at the relevant therapeutic doses of buprenorphine, it may be beneficial in such patients who may have added cardiovascular risk factors.
authors: Nuggehally R
authors: NR
authors: Srinivas
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D002047:Buprenorphine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D002415:Cats; D003402:Creatine Kinase / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D012307:Risk Factors; D013045:Species Specificity; D014280:Triglycerides / Q000097:blood*
chemical_list: D000701:Analgesics, Opioid; D014280:Triglycerides; D002047:Buprenorphine; D003402:Creatine Kinase
keywords: Buprenorphine; creatine kinase; drug-drug interaction; pharmacodynamics; pharmacokinetics; triglyceride