title: Risk of Pancreatic Cancer in Female Textile Workers in Shanghai, China, Exposed to Metals, Solvents, Chemicals, and Endotoxin: Follow-Up to a Nested Case-Cohort Study.
abstract: OBJECTIVE
  We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals, and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously studied cohort.
  
  
  METHODS
  We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly selected sub-cohort of 3191 non-cases. We calculated hazard ratios and 95% confidence intervals using Cox proportional hazards modeling adapted for the case-cohort design.
  
  
  RESULTS
  We observed a statistically significant trend of increasing hazard ratios associated with solvent exposure, but no associations with any of the remaining occupational exposures, including endotoxin and metals.
  
  
  CONCLUSIONS
  Our findings of increasing risk of pancreatic cancer with solvent exposures are consistent with published literature.
authors: Department of Environmental and Occupational Health Sciences (Drs Gallagher, Vedal, and Checkoway); Department of Epidemiology (Drs Romano and Thomas), University of Washington; Program in Epidemiology (Drs Li and Thomas), Division of Public Health Sciences (Ms Ray), Fred Hutchinson Cancer Research Center, Seattle; Department of Epidemiology (Dr Gao), Zhongshan Hospital, Fu Dan University, Shanghai, China; and Department of Family and Preventive Medicine, University of California San Diego, La Jolla.
authors: Nicholas K
authors: NK
authors: Reul
authors: Wenjin
authors: W
authors: Li
authors: Lisa G
authors: LG
authors: Gallagher
authors: Roberta M
authors: RM
authors: Ray
authors: Megan E
authors: ME
authors: Romano
authors: Daoli
authors: D
authors: Gao
authors: David B
authors: DB
authors: Thomas
authors: Sverre
authors: S
authors: Vedal
authors: Harvey
authors: H
authors: Checkoway
mesh_terms: D016022:Case-Control Studies; D002681:China; D004731:Endotoxins / Q000633:toxicity; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008670:Metals / Q000633:toxicity; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D010190:Pancreatic Neoplasms / Q000209:etiology*; D016016:Proportional Hazards Models; D012307:Risk Factors; D012997:Solvents / Q000633:toxicity; D013783:Textile Industry
chemical_list: D004731:Endotoxins; D004785:Environmental Pollutants; D008670:Metals; D012997:Solvents