title: Nephroprotection with saxagliptin.
abstract: The nephroprotective effect of the new anti-diabetic drugs acting on incretin system is suggested by preclinical studies. However, no study evaluating kidney effects of these drugs as primary outcome on the long term has been conducted in patients followed in diabetes centers. We designed a pilot observational study involving two diabetes clinics to evaluate the effect of prolonged treatment with saxagliptin on renal function in type 2 diabetics. Patients were enrolled if treated for at least 12 months with saxagliptin without concurrent changes to anti-hypertensive and lipid-lowering therapy. Primary outcome was to evaluate the effect of saxagliptin on albuminuria and estimated glomerular filtration rate (eGFR). Secondary outcomes were the effects of treatment on common clinical and laboratory parameters. Sixty-three patients were enrolled. After 12 months of treatment with saxagliptin, albuminuria declined from a mean (95%CI) of 39 (25-52) to 22 (14-30) mg/l (P<0.001), and the prevalence of increased albuminuria (>20 mg/L) diminished by 27% versus baseline. The anti-albuminuric effect was independent of glycemic and blood pressure control. The eGFR remained unchanged after treatment in the presence of decreased glycated hemoglobin (from 7.1 to 6.7%). Therefore, this pilot study suggests that saxagliptin treatment in diabetic patients at high renal risk is associated with a reduction in albuminuria and GFR stability. Prospective trials are required to confirm the potential nephroprotective effects of saxagliptin.
authors: Nicolangelo
authors: N
authors: Iazzetta
authors: Carlo
authors: C
authors: Garofalo
authors: Manuela
authors: M
authors: Savino
authors: Adelia
authors: A
authors: Sagliocca
authors: Sara
authors: S
authors: Santangelo
authors: Mario
authors: M
authors: Pacilio
authors: Maria Elena
authors: ME
authors: Liberti
authors: Andrea
authors: A
authors: Camocardi
authors: Camilla
authors: C
authors: Ambrosca
authors: Roberto
authors: R
authors: Minutolo
authors: Luca
authors: L
authors: De Nicola
authors: Giuseppe
authors: G
authors: Conte
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004151:Dipeptides / Q000627:therapeutic use*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000627:therapeutic use*; D006801:Humans; D010865:Pilot Projects; D051436:Renal Insufficiency, Chronic / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D004151:Dipeptides; D054873:Dipeptidyl-Peptidase IV Inhibitors; C502994:saxagliptin; D000218:Adamantane