title: Combined whole-body vibration training and l-citrulline supplementation improves pressure wave reflection in obese postmenopausal women.
abstract: Postmenopausal women have increased wave reflection (augmentation pressure (AP) and index (AIx)) and reduced muscle function that predispose them to cardiac diseases and disability. Our aim was to examine the combined and independent effects of whole-body vibration training (WBVT) and l-citrulline supplementation on aortic hemodynamics and plasma nitric oxide metabolites (NOx) in postmenopausal women. Forty-one obese postmenopausal women were randomized to 3 groups: l-citrulline, WBVT+l-citrulline and WBVT+Placebo for 8 weeks. Brachial and aortic systolic blood pressure, diastolic blood pressure, AP, AIx, AIx adjusted to 75 beats/min (AIx@75), and NOx were measured before and after 8 weeks. All groups similarly decreased (P < 0.05) brachial and aortic pressures as well as AP, and similarly increased (P < 0.05) NOx levels. AIx and AIx@75 decreased (P < 0.01) in the WBVT+l-citrulline and WBVT+Placebo groups, but not in the l-citrulline group. The improvement in AIx@75 (-10.5% ± 8.8%, P < 0.05) in the WBVT+l-citrulline group was significant compared with the l-citrulline group. l-Citrulline supplementation and WBVT alone and combined decreased blood pressures. The combined intervention reduced AIx@75. This study supports the effectiveness of WBVT+l-citrulline as a potential intervention for prevention of hypertension-related cardiac diseases in obese postmenopausal women.
authors: a Department of Nutrition, Food, and Exercise Sciences, The Florida State University, Tallahassee, FL 32306, USA.|b Department of Health and Human performance, Marymount University, Arlington, VA 22207, USA.
authors: Alexei
authors: A
authors: Wong
authors: a Department of Nutrition, Food, and Exercise Sciences, The Florida State University, Tallahassee, FL 32306, USA.
authors: Stacey
authors: S
authors: Alvarez-Alvarado
authors: a Department of Nutrition, Food, and Exercise Sciences, The Florida State University, Tallahassee, FL 32306, USA.
authors: Salvador J
authors: SJ
authors: Jaime
authors: a Department of Nutrition, Food, and Exercise Sciences, The Florida State University, Tallahassee, FL 32306, USA.
authors: Amber W
authors: AW
authors: Kinsey
authors: a Department of Nutrition, Food, and Exercise Sciences, The Florida State University, Tallahassee, FL 32306, USA.
authors: Maria T
authors: MT
authors: Spicer
authors: a Department of Nutrition, Food, and Exercise Sciences, The Florida State University, Tallahassee, FL 32306, USA.
authors: Takudzwa A
authors: TA
authors: Madzima
authors: a Department of Nutrition, Food, and Exercise Sciences, The Florida State University, Tallahassee, FL 32306, USA.
authors: Arturo
authors: A
authors: Figueroa
mesh_terms: D001011:Aorta / Q000503:physiopathology*; D062186:Arterial Pressure; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D002956:Citrulline / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D019587:Dietary Supplements; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005431:Florida; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D017698:Postmenopause; D063177:Pulse Wave Analysis; D013997:Time Factors; D016896:Treatment Outcome; D059289:Vascular Stiffness; D014732:Vibration / Q000627:therapeutic use*
chemical_list: D002956:Citrulline
keywords: aortic blood pressure; femmes post-ménopausées; l-citrulline; onde de réflexion; postmenopausal women; pression sanguine aortique; vibration globale du corps; wave reflection; whole-body vibration