title: Skeletal muscle regeneration in cancer cachexia.
abstract: Muscle wasting is the most important phenotypic and clinical feature of cancer cachexia, and the principal cause of impaired physical function, fatigue, and respiratory complications. Muscle loss has been attributed to a variable combination of reduced nutritional intake and an imbalance between anabolic and catabolic processes. It has been suggested that defective skeletal muscle regeneration may also contribute to muscle wasting in cancer patients. However, there is little in vitro or in vivo data available, in either animals or in humans, regarding skeletal muscle regeneration in cancer wasting. The aim of the present review is to define the role of skeletal muscle regeneration in the muscle wasting of cancer patients and to determine possible therapeutic implications.
authors: Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Rome, Italy.
authors: Maurizio
authors: M
authors: Bossola
authors: Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome, Italy.
authors: Emanuele
authors: E
authors: Marzetti
authors: Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Rome, Italy.
authors: Fausto
authors: F
authors: Rosa
authors: Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Rome, Italy.
authors: Fabio
authors: F
authors: Pacelli
mesh_terms: D000818:Animals; D002100:Cachexia / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D018482:Muscle, Skeletal / Q000473:pathology* / Q000502:physiology*; D009369:Neoplasms / Q000150:complications*; D012038:Regeneration
keywords: MyoD; Necdin; Pax7; atrophy; cachexia; cancer; regeneration; skeletal muscle; wasting