title: A Comprehensive Meta-analysis of Genetic Associations Between Key Polymorphic Loci in DNA Repair Genes and Glioma Risk.
abstract: Genetic variants found in DNA repair genes (ERCC1, rs3212986; ERCC2, rs13181; ERCC4, rs1800067; ERCC5, rs17655; XRCC1, rs1799782, rs25487, rs25489; XRCC3, rs861539) have been reported to have an ambivalent association with the development of glioma. In the present study, a meta-analysis was conducted to confirm the relationship, taking heterogeneity of population into consideration. We analyzed 21 articles of 6 genes along with 8 single nucleotide polymorphisms (SNPs) (24,078 cases and 30,926 healthy individuals), which assessed the relationship between nucleotide excision, base excision, double-strand break repair gene, and the development of glioma under five models. All statistical analysis was implemented by the software of R 3.2.1, and the relationships between key polymorphic loci in DNA repair genes and glioma were quantified by the pooled odds ratio (OR) and 95 % confidential intervals. Overall, the synthesized evidence demonstrated that the SNP of rs13181 and rs1799782 significantly increased the risk of glioma whereas SNP of rs1800067 were significantly associated with a decrease in the risk of glioma. Additionally, subgroup analyses of 8 SNPs by ethnicity indicated that the mutation of rs13181, rs1800067 were apparently protective factors of glioma among Asians, while the mutation of rs13181 was a risk factors of glioma in Caucasians. Furthermore, the mutation of rs1799782 significantly raises the risk of glioma for Asian. Our study suggested that rs13181*C and rs1799782*A are risk alleles for glioma; rs1800067*A are beneficial alleles for decreased susceptibility to glioma. Future studies with large sample size and other races are strongly recommended to confirm the results from this study.
authors: Department of Pathology, Jilin Medical University, Jilin, 132013, China.
authors: Ling
authors: L
authors: Qi
authors: Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.
authors: Hong-Quan
authors: HQ
authors: Yu
authors: Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.
authors: Yu
authors: Y
authors: Zhang
authors: Department of Radiation Oncology, First Hospital of Jilin University, Changchun, 130021, China.
authors: Li-Juan
authors: LJ
authors: Ding
authors: Department of Pathology, Jilin Medical University, Jilin, 132013, China.
authors: Dong-Hai
authors: DH
authors: Zhao
authors: Department of Pathology, Jilin Medical University, Jilin, 132013, China.
authors: Peng
authors: P
authors: Lv
authors: Department of Pathology, Jilin Medical University, Jilin, 132013, China.
authors: Wei-Yao
authors: WY
authors: Wang
authors: Medical Research Laboratory, Jilin Medical University, No.5 Jilin District, Jilin, 132013, China. xuye_mpc@outlook.com.
authors: Ye
authors: Y
authors: Xu
mesh_terms: D001932:Brain Neoplasms / Q000453:epidemiology / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D056726:Genetic Association Studies / Q000379:methods*; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005910:Glioma / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
keywords: DNA repair genes; ERCC; Genetic polymorphisms; Glioma; Meta-analysis; XRCC