title: Combinatorial synthesis of deuterium-enriched (S)-oxybutynin.
abstract: The concept of deuterium enrichment has gained more attention due to its advantages in the studies of clinical pharmacokinetics and metabolic profiles. In addition, it is cost and time efficient to develop deuterium-enriched drugs. Herein we built a combinatorial library of deuterated (S)-oxybutynins which all 8 D-compounds were characterized by MS, [Formula: see text] NMR and [Formula: see text]C NMR.
authors: School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.|Marine Biomedical Research Institute of Qingdao, Qingdao, 266073, People's Republic of China.
authors: Feng
authors: F
authors: Li
authors: School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.|Marine Biomedical Research Institute of Qingdao, Qingdao, 266073, People's Republic of China.
authors: Wenfeng
authors: W
authors: Jiang
authors: Department of Chemistry, University of Nevada, Reno, Reno, 89557-0216, USA. aczarnik@unr.edu.
authors: Anthony W
authors: AW
authors: Czarnik
authors: School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China. wbli92128@ouc.edu.cn.|Marine Biomedical Research Institute of Qingdao, Qingdao, 266073, People's Republic of China. wbli92128@ouc.edu.cn.
authors: Wenbao
authors: W
authors: Li
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003903:Deuterium / Q000737:chemistry*; D008333:Mandelic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D008333:Mandelic Acids; D003903:Deuterium; C005419:oxybutynin
keywords: Combinatorial chemistry; Derivatives; Deuterium; Oxybutynin