title: Adenoid Cystic Carcinoma Can Be Driven by MYB or MYBL1 Rearrangements: New Insights into MYB and Tumor Biology.
abstract: A majority of adenoid cystic carcinomas (AdCC)-rare tumors of the salivary gland and some other organs-have recently been found to be driven by chromosomal translocations resulting in MYB-NFIB fusions. Brayer and colleagues and Mitani and colleagues have now reported that AdCCs can alternatively be driven by similar rearrangements involving a second MYB family gene, MYBL1, and that these two drivers act in remarkably similar ways.
authors: School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia. t.gonda@uq.edu.au.
authors: Thomas J
authors: TJ
authors: Gonda
authors: Peter MacCallum Cancer Centre, the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Melbourne, Victoria, Australia.
authors: Robert G
authors: RG
authors: Ramsay
mesh_terms: D003528:Carcinoma, Adenoid Cystic; D020570:Genes, myb; D006801:Humans; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion