title: Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial.
abstract: Few studies have investigated the effect of vitamin E in reducing the cisplatin (CDDP)-induced ototoxicity. This study evaluated vitamin E supplementation as a protecting agent against CDDP-induced ototoxicity.
  
  
  
  Patients who started CDDP were randomly assigned to receive vitamin E supplementation at 400 mg per day (group 1) or placebo (group 2). Audiograms and evoked brainstem responses were obtained at baseline, and after 1, 2, and 3 months.
  
  
  
  Twenty-three patients affected by solid malignancies were enrolled (13 in group 1 and 10 in group 2). At 1 month, a significant hearing loss in group 2 at both 2000 HZ (right ear: p = .05; left ear: p = .04) and 8000 HZ (right ear: p = .04; left ear: p = .03) was detected when compared to baseline values. Audiograms did not show significant changes. At 1 month, evoked brainstem responses remained unchanged in both arms without significant differences between groups.
  
  
  
  These preliminary findings confirm the neuroprotective properties of vitamin E against the CDDP-induced ototoxicity. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2118-E2121, 2016.
authors: Neuro-Oncology Unit, Regina Elena Cancer Institute, Rome, Italy.
authors: Veronica
authors: V
authors: Villani
authors: Neuro-Oncology Unit, Regina Elena Cancer Institute, Rome, Italy.
authors: Chiara
authors: C
authors: Zucchella
authors: Department of Otolaryngology, Regina Elena National Cancer Institute, Rome, Italy.
authors: Giovanni
authors: G
authors: Cristalli
authors: Neuro-Oncology Unit, Regina Elena Cancer Institute, Rome, Italy.
authors: Edvina
authors: E
authors: Galiè
authors: Department of Otolaryngology, Regina Elena National Cancer Institute, Rome, Italy.
authors: Francesco
authors: F
authors: Bianco
authors: Statistic Unit, Regina Elena National Cancer Institute, Rome, Italy.
authors: Diana
authors: D
authors: Giannarelli
authors: Department of Oncology, Regina Elena National Cancer Institute, Rome, Italy.
authors: Silvia
authors: S
authors: Carpano
authors: Department of Otolaryngology, Regina Elena National Cancer Institute, Rome, Italy.
authors: Giuseppe
authors: G
authors: Spriano
authors: Neuro-Oncology Unit, Regina Elena Cancer Institute, Rome, Italy.
authors: Andrea
authors: A
authors: Pace
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D019587:Dietary Supplements; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000066829:Neuroprotection; D024502:alpha-Tocopherol / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D024502:alpha-Tocopherol; D002945:Cisplatin
keywords: antioxidant; cisplatin; neuroprotection; ototoxicity; vitamin E