title: Optical mammography: bilateral breast symmetry in hemoglobin saturation maps.
abstract: We present a study of the bilateral symmetry of human breast hemoglobin saturation maps measured with a broadband optical mammography instrument. We have imaged 21 patients with unilateral breast cancer, 32 patients with unilateral benign lesions, and 27 healthy patients. An image registration process was applied to the bilateral hemoglobin saturation (SO 2 SO2 ) images by assigning each pixel to the low, middle, or high range of SO 2 SO2 values, where the thresholds for the categories were the 15th and 85th percentiles of the individual saturation range. The Dice coefficient, which is a measure of similarity, was calculated for each patient’s pair of right and left breast SO 2 SO2 images. The invasive cancer patients were found to have an average Dice coefficient value of 0.55±0.07 0.55±0.07 , which was significantly lower than the benign and healthy groups (0.61±0.11 0.61±0.11 and 0.62±0.12 0.62±0.12 , respectively). Although differences were seen in a group analysis, the healthy patient Dice coefficients spanned a wide range, limiting the diagnostic capabilities of this SO 2 SO2 symmetry analysis on an individual basis. Our results suggest that for assessing the SO 2 SO2 contrast of breast lesions, it may be better to select a reference tissue in the ipsilateral rather than the contralateral breast.
authors: Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, United States.
authors: Pamela G
authors: PG
authors: Anderson
authors: Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, United States.
authors: Angelo
authors: A
authors: Sassaroli
authors: Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, United States.
authors: Jana M
authors: JM
authors: Kainerstorfer
authors: Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, United States.
authors: Nishanth
authors: N
authors: Krishnamurthy
authors: Tufts Medical Center, Department of Radiology, 800 Washington Street, Boston, Massachusetts 02111, United States.
authors: Sirishma
authors: S
authors: Kalli
authors: Tufts Medical Center, Department of Radiology, 800 Washington Street, Boston, Massachusetts 02111, United States.
authors: Shital S
authors: SS
authors: Makim
authors: Tufts Medical Center, Department of Surgery, 800 Washington Street, Boston, Massachusetts 02111, United States.
authors: Roger A
authors: RA
authors: Graham
authors: Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, United States.
authors: Sergio
authors: S
authors: Fantini
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000098:blood supply*; D005260:Female; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D061848:Optical Imaging / Q000379:methods*; D055815:Young Adult
chemical_list: D006454:Hemoglobins