title: Sustained Enhancement of Lateral Inhibitory Circuit Maintains Cross Modal Cortical Reorganization.
abstract: Deprivation of one modality can lead to the improvement of other intact modalities. We have previously reported that visual deprivation drives AMPA receptors into synapses from layer4 to 2/3 in the barrel cortex and sharpens functional whisker-barrel map at layer2/3 2 days after the beginning of visual deprivation. Enhanced excitatory synaptic transmission at layer4-2/3 synapses is transient and returns to the base line level a week after the beginning of visual deprivation. Here we found that sharpened whisker-barrel function is maintained at least for a week in visually deprived animals. While increased AMPA receptor-mediated synaptic transmission at layer4-2/3 synapses dropped to the base line a week after the beginning of visual deprivation, lateral inhibitory synaptic transmission onto the neighboring barrel was kept strengthened for a week of visually deprived animals. Thus, transient strengthening of excitatory synapses at layer4-2/3 in the barrel cortex could trigger the enhancement of inhibitory inputs to neighboring barrel, and sustained lateral inhibition can maintain the sharpening of whisker-barrel map in visually deprived animals.
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Waki
authors: W
authors: Nakajima
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Susumu
authors: S
authors: Jitsuki
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Akane
authors: A
authors: Sano
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Takuya
authors: T
authors: Takahashi
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology; D004594:Electrophysiology; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism; D018091:Receptors, AMPA / Q000378:metabolism*; D012683:Sensory Deprivation / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D015398:Signal Transduction; D013003:Somatosensory Cortex / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission; D014785:Vision, Ocular
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D018091:Receptors, AMPA; D012701:Serotonin