title: Polyunsaturated Fatty Acids Are Associated With Behavior But Not With Cognition in Children With and Without ADHD: An Italian study.
abstract: This study aimed to investigate the relationship between polyunsaturated fatty acids (PUFAs) status, cognitive, and behavioral traits of ADHD in school-aged children.
  
  
  
  Seventy-three children with and without ADHD were assessed with cognitive tasks and behavioral rating scales including quality of life and global functioning at baseline of an intervention trial (clinicaltrials.gov NCT01796262). Correlation analyses were performed between the cognitive tasks/behavioral ratings and blood PUFA levels.
  
  
  
  Children with ADHD had lower levels of DHA, omega-3 index, and total PUFA. PUFAs were positively associated with behavior but not consistently related to cognitive domains.
  
  
  
  The present study confirms that children with ADHD display abnormal fatty acid profiles within an Italian setting. Furthermore, PUFAs were associated with behavior but not with cognition. Accordingly, for the first time, lower blood levels of PUFA were associated not only with symptoms of ADHD but also with a poorer quality of life.
authors: 1 Scientific Institute, IRCCS Eugenio Medea, Lecco, Italy.
authors: Alessandro
authors: A
authors: Crippa
authors: 2 Pediatric Clinic, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, University of Milan, Italy.
authors: Carlo
authors: C
authors: Agostoni
authors: 1 Scientific Institute, IRCCS Eugenio Medea, Lecco, Italy.
authors: Maddalena
authors: M
authors: Mauri
authors: 1 Scientific Institute, IRCCS Eugenio Medea, Lecco, Italy.
authors: Massimo
authors: M
authors: Molteni
authors: 1 Scientific Institute, IRCCS Eugenio Medea, Lecco, Italy.|3 Villa San Benedetto Hospital, Hermanas Hospitalarias, FoRiPsi, Albese con Cassano, Italy.
authors: Maria
authors: M
authors: Nobile
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology*; D016022:Case-Control Studies; D002648:Child; D002652:Child Behavior / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003430:Cross-Sectional Studies; D015525:Fatty Acids, Omega-3 / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D011788:Quality of Life
chemical_list: D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated
keywords: ADHD; behavior; cognition; fatty acids; quality of life