title: Influence of hydrophilic polymers on functional properties and wound healing efficacy of hydrocolloid based wound dressings.
abstract: The purpose of this study was to investigate the influence of different hydrophilic polymers on the swelling, bioadhesion and mechanical strength of hydrocolloid wound dressings (HCDs) in order to provide an appropriate composition for a hydrocolloid wound dressing system. In this study, the HCDs were prepared with styrene-isoprene-styrene copolymer (SIS) and polyisobutylene (PIB) as the base using a hot melting method. Additionally, numerous SIS/PIB-based HCDs were prepared with six hydrophilic polymers, and their wound dressing properties were assessed. Finally, the wound healing efficacy of the selected formulations was compared to a commercial wound dressing. The swelling ratio, bioadhesive force and mechanical strengths of HCDs were increased in the order of sodium alginate>sodium CMC=poloxamer=HPMC>PVA=PVP, sodium alginate>sodium CMC=poloxamer>PVA>HPMC=PVP and sodium alginate≥PVA>PVP=HPMC=sodium CMC>poloxamer, respectively. Among the hydrophilic polymers tested, sodium alginate most enhanced the swelling capacity, bioadhesive force and mechanical strengths. Thus, the hydrophilic polymers played great role in the swelling, bioadhesion and mechanical strength of SIS/PIB-based HCDs. The HCD formulation composed of PIB, SIS, liquid paraffin and sodium alginate at the weight ratio of 20/25/12/43 gave better wound dressing properties and more excellent wound healing efficacy than the commercial wound dressing. Therefore, the novel HCD formulation could be a promising hydrocolloid system for wound dressings.
authors: College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea.
authors: Sung Giu
authors: SG
authors: Jin
authors: College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea; Faculty of Pharmacy, University of Central Punjab, 1-Khayaban-e-Jinnah, Johar, Lahore 54000, Pakistan.
authors: Abid Mehmood
authors: AM
authors: Yousaf
authors: College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea.
authors: Kyeong Soo
authors: KS
authors: Kim
authors: College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea.
authors: Dong Wuk
authors: DW
authors: Kim
authors: College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea.
authors: Dong Shik
authors: DS
authors: Kim
authors: College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea.
authors: Jin Ki
authors: JK
authors: Kim
authors: College of Pharmacy, Yeungnam University, 214-1, Dae-Dong, Gyongsan 712-749, South Korea.
authors: Chul Soon
authors: CS
authors: Yong
authors: School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon 440-746, South Korea.
authors: Yu Seok
authors: YS
authors: Youn
authors: College of Pharmacy, Yeungnam University, 214-1, Dae-Dong, Gyongsan 712-749, South Korea. Electronic address: jongohkim@yu.ac.kr.
authors: Jong Oh
authors: JO
authors: Kim
authors: College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea. Electronic address: hangon@hanyang.ac.kr.
authors: Han-Gon
authors: HG
authors: Choi
mesh_terms: D000268:Adhesiveness; D000818:Animals; D047070:Bandages, Hydrocolloid; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D055595:Mechanical Phenomena; D008812:Mice, Hairless; D009821:Oils / Q000737:chemistry; D010232:Paraffin / Q000737:chemistry; D011108:Polymers / Q000737:chemistry* / Q000627:therapeutic use; D017207:Rats, Sprague-Dawley; D013718:Tensile Strength; D014945:Wound Healing / Q000187:drug effects
chemical_list: D009821:Oils; D011108:Polymers; D010232:Paraffin; C015418:paraffin oils
keywords: Bioadhesive force; Healing efficacy; Hydrocolloid wound dressing; Hydrophilic polymers; Mechanical properties; Sodium alginate