title: Association of Elevated High Sensitivity Cardiac Troponin T(hs-cTnT) Levels with Hemorrhagic Transformation and 3-Month Mortality in Acute Ischemic Stroke Patients with Rheumatic Heart Disease in China.
abstract: OBJECTIVE
  Elevated levels of high sensitivity cardiac troponin T (hs-cTnT) occur in a substantial proportion of patients with acute ischemic stroke (AIS) and can predict poor outcome and mortality after stroke. Whether elevated hs-cTnT levels can also predict hemorrhagic transformation (HT) or prognosis in AIS patients with rheumatic heart disease (RHD) remains unclear.
  
  
  METHODS
  Data from the Chengdu Stroke Registry on consecutive AIS patients with RHD admitted to West China Hospital within 1 month of stroke onset from October 2011 to February 2014 were examined. Clinico-demographic characteristics, HT, functional outcomes and stroke recurrence were compared between patients with elevated hs-cTnT levels (≥14 ng/L) and patients with normal hs-cTnT levels (<14 ng/L).
  
  
  RESULTS
  The final analysis involved 84 patients (31 males; mean age, 61.6±12.2 years), of whom serum hs-cTnT levels were elevated in 58.3%. Renal impairment was independently associated with elevated hs-cTnT levels (OR 4.184, 95%CI 1.17 to 15.01, P = 0.028), and patients with elevated hs-cTnT levels were at significantly higher risk of HT, 3-month mortality and 3-month disability/mortality (all P≤0.029). After controlling for age, sex, hypertension, renal impairment and National Institutes of Health Stroke Scale score on admission, the risk of HT and 3-month mortality was, respectively, 4.0- and 5.5-fold higher in patients with elevated hs-cTnT levels than in patients with normal hs-cTnT levels.
  
  
  CONCLUSIONS
  Elevated hs-cTnT levels are independently associated with HT and 3-month mortality in AIS patients with RHD. These results with a small cohort should be verified and extended in large studies.
authors: Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Junfeng
authors: J
authors: Liu
authors: Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Deren
authors: D
authors: Wang
authors: Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Yao
authors: Y
authors: Xiong
authors: Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Bian
authors: B
authors: Liu
authors: Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Zilong
authors: Z
authors: Hao
authors: Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Wendan
authors: W
authors: Tao
authors: Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Ming
authors: M
authors: Liu
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020300:Intracranial Hemorrhages / Q000097:blood / Q000209:etiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012214:Rheumatic Heart Disease / Q000097:blood* / Q000150:complications; D020521:Stroke / Q000097:blood* / Q000209:etiology / Q000401:mortality*; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T