title: MicroRNA-96 Regulates Apoptosis by Targeting PDCD4 in Human Glioma Cells.
abstract: Glioblastoma multiforme, the most common and aggressive form of primary brain tumor, presents a dismal prognosis. MicroRNAs play a critical role in the initiation, progression, and metastasis of cancer; however, the potential biological role of miRNAs in glioblastoma multiforme remains largely unknown. In our study, we found that microRNA-96 is upregulated in glioma tissues than in normal human brains. Transfection of microRNA-96 mimics into glioma cells significantly decreases apoptosis by suppressing PDCD4, a well-known tumor suppressor that is involved in apoptosis. In contrast, knockdown of microRNA-96 enhanced apoptosis. In vivo, microRNA-96 overexpression inhibits the apoptosis and increases tumor growth. These data suggest that microRNA-96 is a potential molecular target for glioma treatment.
authors: 1 Clinical Laboratory, Guizhou Aerospace Hospital, Zunyi, China.
authors: Qing-Qing
authors: QQ
authors: Ma
authors: 2 Department of Anesthesiology, The People's Hospital of Chengyang District, Qingdao, China.
authors: Jian-Ting
authors: JT
authors: Huang
authors: 1 Clinical Laboratory, Guizhou Aerospace Hospital, Zunyi, China.
authors: Yun-Gang
authors: YG
authors: Xiong
authors: 1 Clinical Laboratory, Guizhou Aerospace Hospital, Zunyi, China.
authors: Xiao-Yan
authors: XY
authors: Yang
authors: 1 Clinical Laboratory, Guizhou Aerospace Hospital, Zunyi, China.
authors: Ran
authors: R
authors: Han
authors: 1 Clinical Laboratory, Guizhou Aerospace Hospital, Zunyi, China.
authors: Wang-Wen
authors: WW
authors: Zhu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D005910:Glioma / Q000235:genetics*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D034622:RNA Interference; D016601:RNA-Binding Proteins / Q000235:genetics*; D023041:Xenograft Model Antitumor Assays
chemical_list: D051017:Apoptosis Regulatory Proteins; C541492:MIRN96 microRNA, human; D035683:MicroRNAs; C114487:PDCD4 protein, human; D016601:RNA-Binding Proteins
keywords: PDCD4; apoptosis; glioma; microRNA-96