title: Tumour-associated antigens and their anti-cancer applications.
abstract: So far, a number of tumour-associated antigens (TAAs), such as heat shock proteins, alpha-fetoprotein, carcino-embryonic antigen and others have been identified in a variety of malignant tumours. Differences in the expression levels of TAAs in cancers compared with normal cells have led to these antigens being investigated as diagnostic and prognostic biomarkers or exciting targets in cancer treatment. Here, we systematically list the current representative TAAs to shed some light on current approaches and challenges for their anti-cancer application in cancer therapy. In this review, we discuss the ongoing pre-clinical studies and clinical development of TAAs in human cancers, and the potential application of these TAAs in the diagnosis and prognosis for cancer treatment.
authors: Translational Medicine Center, Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, China.
authors: C-C
authors: CC
authors: Liu
authors: Translational Medicine Center, Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, China.
authors: H
authors: H
authors: Yang
authors: Translational Medicine Center, Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, China.
authors: R
authors: R
authors: Zhang
authors: Translational Medicine Center, Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, China.
authors: J-J
authors: JJ
authors: Zhao
authors: Spine Surgery, Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, China.
authors: D-J
authors: DJ
authors: Hao
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000276:immunology; D053673:Glypicans / Q000276:immunology; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology*; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000276:immunology; D015843:Serpins / Q000276:immunology; D019396:Tissue Polypeptide Antigen / Q000276:immunology; D000509:alpha-Fetoproteins / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D053673:Glypicans; D006360:Heat-Shock Proteins; D015843:Serpins; D019396:Tissue Polypeptide Antigen; D000509:alpha-Fetoproteins; C051072:squamous cell carcinoma-related antigen; D017430:Prostate-Specific Antigen
keywords: cancer; diagnosis; prognosis; tumour-associated antigens