title: Amplitude of Low-Frequency Fluctuations in Multiple-Frequency Bands in Acute Mild Traumatic Brain Injury.
abstract: Functional disconnectivity during the resting state has been observed in mild traumatic brain injury (mTBI) patients during the acute stage. However, it remains largely unknown whether the abnormalities are related to specific frequency bands of the low-frequency oscillations (LFO). Here, we used the amplitude of low-frequency fluctuations (ALFF) to examine the amplitudes of LFO in different frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz; and typical: 0.01-0.08 Hz) in patients with acute mTBI. A total of 24 acute mTBI patients and 24 age-, sex-, and education-matched healthy controls participated in this study. In the typical band, acute mTBI patients showed lower standardized ALFF in the right middle frontal gyrus and higher standardized ALFF in the right lingual/fusiform gyrus and left middle occipital gyrus. Further analyses showed that the difference between groups was concentrated in a narrower (slow-4) frequency band. In the slow-5 band, mTBI patients only exhibited higher standardized ALFF in the occipital areas. No significant correlation between the mini-mental state examination score and the standardized ALFF value was found in any brain region in the three frequency bands. Finally, no significant interaction between frequency bands and groups was found in any brain region. We concluded that the abnormality of spontaneous brain activity in acute mTBI patients existed in the frontal lobe as well as in distributed brain regions associated with integrative, sensory, and emotional roles, and the abnormal spontaneous neuronal activity in different brain regions could be better detected by the slow-4 band. These findings might contribute to a better understanding of local neural psychopathology of acute mTBI. Future studies should take the frequency bands into account when measuring intrinsic brain activity of mTBI patients.
authors: Department of Radiology, The First Affiliated Hospital of Nanchang University , Nanchang , China.
authors: Jie
authors: J
authors: Zhan
authors: Department of Radiology, The First Affiliated Hospital of Nanchang University , Nanchang , China.
authors: Lei
authors: L
authors: Gao
authors: Department of Radiology, The First Affiliated Hospital of Nanchang University , Nanchang , China.
authors: Fuqing
authors: F
authors: Zhou
authors: The Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University , Xi'an , China.
authors: Lijun
authors: L
authors: Bai
authors: Department of Radiology, The First Affiliated Hospital of Nanchang University , Nanchang , China.
authors: Hongmei
authors: H
authors: Kuang
authors: Department of Radiology, The First Affiliated Hospital of Nanchang University , Nanchang , China.
authors: Laichang
authors: L
authors: He
authors: Department of Radiology, The First Affiliated Hospital of Nanchang University , Nanchang , China.
authors: Xianjun
authors: X
authors: Zeng
authors: Department of Radiology, The First Affiliated Hospital of Nanchang University , Nanchang , China.
authors: Honghan
authors: H
authors: Gong
keywords: acute; amplitude of low-frequency fluctuations; frequency band; mild traumatic brain injury; resting-state fMRI