title: Polycystic Ovary Syndrome, Obesity, and Pregnancy.
abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to one in five reproductive-aged women. It is underpinned by insulin resistance and hyperandrogenism and is associated with metabolic, reproductive, and psychological features. Women with PCOS have higher rates of obesity and central adiposity compared with women without PCOS, and weight strongly influences prevalence and clinical severity of PCOS. Women with PCOS may have subfertility and women should be aware of factors affecting fertility, in particular the impact of obesity and age. Once pregnant, women with PCOS have significantly increased risk of pregnancy-related complications including gestational diabetes, hypertensive disorders, premature delivery, and delivery by cesarean section. The offspring of women with PCOS may have increased risk of congenital abnormalities and hospitalization in childhood. Clinicians should be aware of the increased risk and screen, prevent, and manage accordingly.
authors: Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
authors: Anju E
authors: AE
authors: Joham
authors: Unit of Gynecology & Obstetrics, IRCCS - Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors: Stefano
authors: S
authors: Palomba
authors: School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
authors: Roger
authors: R
authors: Hart
mesh_terms: D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control; D008019:Life Style; D000068097:Maternal Health; D008427:Maternal Health Services; D009765:Obesity / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000517:prevention & control; D011314:Preventive Health Services; D018570:Risk Assessment; D012307:Risk Factors; D040242:Risk Reduction Behavior