title: Identification of protein adduction using mass spectrometry: Protein adducts as biomarkers and predictors of toxicity mechanisms.
abstract: The determination of protein-xenobiotic adducts using mass spectrometry is an emerging area which allows detailed understanding of the underlying mechanisms involved in toxicity. These approaches can also be used to reveal potential biomarkers of exposure or toxic response. The following review covers studies of protein adducts resulting from exposure to a wide variety of xenobiotics including organophosphates, polycyclic aromatic hydrocarbons, acetaminophen, alkylating agents and other related compounds.
authors: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA, 30602-2352, USA.
authors: Xiangkun
authors: X
authors: Yang
authors: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA, 30602-2352, USA.
authors: Michael G
authors: MG
authors: Bartlett
mesh_terms: D000082:Acetaminophen / Q000737:chemistry / Q000633:toxicity; D000477:Alkylating Agents / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D015415:Biomarkers / Q000737:chemistry; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D008958:Models, Molecular; D010755:Organophosphates / Q000737:chemistry / Q000633:toxicity; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000633:toxicity; D011506:Proteins / Q000737:chemistry*; D015262:Xenobiotics / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000477:Alkylating Agents; D015415:Biomarkers; D010755:Organophosphates; D011084:Polycyclic Aromatic Hydrocarbons; D011506:Proteins; D015262:Xenobiotics; D000082:Acetaminophen