title: Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs.
abstract: OBJECTIVE
  To assess the efficacy of triclabendazole (TCBZ) in porcine cysticercosis.
  
  
  METHODS
  Eighteen naturally infected cysticercosis pigs were divided into 3 groups of 6 individuals each. The first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight, the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo (control group). All animals were kept under the same management conditions. The pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between groups.
  
  
  RESULTS
  All pigs treated with oxfendazole had only degenerated cysts in their carcasses. In contrast, TCBZ had very little effect against the parasitic cysts. Cysts from pigs in the TCBZ group looked apparently normal after treatment. However, histological evaluation showed a mild to moderate degree of inflammation.
  
  
  CONCLUSIONS
  TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.
authors: School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima 41, Peru.
authors: Ana
authors: A
authors: Vargas-Calla
authors: School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima 41, Peru. Electronic address: lucho92@yahoo.com.
authors: Luis A
authors: LA
authors: Gomez-Puerta
authors: School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima 41, Peru.
authors: Juan
authors: J
authors: Calcina
authors: School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima 41, Peru.
authors: Omar
authors: O
authors: Gonzales-Viera
authors: School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima 41, Peru.
authors: Cesar
authors: C
authors: Gavidia
authors: School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima 41, Peru.
authors: Maria T
authors: MT
authors: Lopez-Urbina
authors: Cysticercosis Elimination Program and Center for Global Heath Tumbes, Universidad Peruana Cayetano Heredia, Tumbes, Peru; Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima 31, Peru.
authors: Hector H
authors: HH
authors: Garcia
authors: School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima 41, Peru.
authors: Armando E
authors: AE
authors: Gonzalez
keywords: Cysticercosis; Oxfendazole; Taenia solium; Treatment; Triclabendazole