title: Cellular and molecular aspects of pancreatic cancer.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy that affects nearly 50,000 patients each year. The overall 5-year survival rate for this malignancy remains the lowest of any cancer at around 7% due to limited diagnostic methods, disease aggressiveness and a lack of targeted therapeutic interventions. This review highlights the successes achieved over the past several decades as well as the significant cellular and molecular hurdles that remain in combatting this deadly disease at a translational level.
authors: Developmental Oncogene Laboratory, Department of Biology, California State University Northridge, Northridge, CA 91330, USA.
authors: A
authors: A
authors: Gharibi
authors: Developmental Oncogene Laboratory, Department of Biology, California State University Northridge, Northridge, CA 91330, USA.
authors: Y
authors: Y
authors: Adamian
authors: Developmental Oncogene Laboratory, Department of Biology, California State University Northridge, Northridge, CA 91330, USA. Electronic address: jonathan.kelber@csun.edu.
authors: J A
authors: JA
authors: Kelber
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology; D021441:Carcinoma, Pancreatic Ductal / Q000209:etiology / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000401:mortality / Q000473:pathology* / Q000628:therapy
keywords: Cancer progression; GEMMs; Kinases; Metabolism and desmoplasia; Pancreatic cancer; Therapy resistance