title: Association of KCNQ1 polymorphisms with gliclazide efficacy in Chinese type 2 diabetic patients.
abstract: OBJECTIVE
  To investigate the effects of KCNQ1 polymorphisms on the efficacy of gliclazide in type 2 diabetic patients.
  
  
  METHODS
  A total of 443 newly diagnosed type 2 diabetic patients were included in this study. After enrollment, patients went on an 8-week gliclazide monotherapy. Fasting plasma glucose (FPG) was measured before and after the treatment. Life-style information was collected by weekly follow-up. Genotyping of the two single-nucleotide polymorphisms was performed using the single base primer extension method. T-test, one-way analysis of variance, and Pearson χ-test were used to evaluate the effects of rs2237892 and rs2237897 on the FPG reduction and treatment success rate.
  
  
  RESULTS
  After 8 weeks of gliclazide therapy, the FPG decreased significantly from 10.9±2.8 to 7.4±2.2 mmol/l (P<0.001). Compared with the CC genotype, patients with CT or TT genotypes of rs2237897 achieved greater reduction in FPG (3.9±2.6 vs. 3.2±2.4 mmol/l, P=0.003; 33.9±19.0 vs. 27.7±17.4%, P<0.001) and a higher rate of treatment success (74.1 vs. 65.2%, P=0.042 for criterion 1; 61.1 vs. 44.5%, P<0.001 for criterion 2, respectively), whereas no significant difference was found in the FPG reduction and treatment success rate among different genotypes of rs2237892.
  
  
  CONCLUSIONS
  Our results indicated that a common variant of KCNQ1, rs2237897, was associated with the efficacy of gliclazide after 8-week monotherapy in Chinese newly diagnosed type 2 diabetic patients. The FPG reduction and treatment success rate were significantly higher in carriers of CT and TT genotypes.
authors: aDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing bDepartment of Endocrinology, Central Hospital of Shenzhen Guangming New District, Shenzhen cDepartment of Endocrinology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, People's Republic of China.
authors: Fangfang
authors: F
authors: Duan
authors: Yali
authors: Y
authors: Guo
authors: Liuwei
authors: L
authors: Zhang
authors: Peixian
authors: P
authors: Chen
authors: Xiaozhu
authors: X
authors: Wang
authors: Zhike
authors: Z
authors: Liu
authors: Yonghua
authors: Y
authors: Hu
authors: Shenren
authors: S
authors: Chen
authors: Dafang
authors: D
authors: Chen