title: Factors associated with failure to complete adjuvant chemotherapy in pancreatic cancer.
abstract: BACKGROUND
  The importance of completing adjuvant chemotherapy in pancreatic cancer is becoming recognized. However, the clinicopathological factors associated with failure to complete adjuvant chemotherapy remain unclear.
  
  
  METHODS
  A total of 135 patients were analyzed to identify the factors associated with failure to complete adjuvant chemotherapy.
  
  
  RESULTS
  Ninety patients completed planned adjuvant chemotherapy, whereas 45 patients failed to complete adjuvant chemotherapy. Lower preoperative prognostic nutritional index, intraoperative blood transfusion, and organ and/or space surgical site infection, and advanced tumor stage were associated with failure to complete adjuvant chemotherapy. Neoadjuvant chemoradiotherapy was associated with significantly lower prognostic nutritional index, less incidence of organ and/or space surgical site infection, and earlier tumor stage, suggesting the conflicting effects of neoadjuvant chemoradiotherapy on completing adjuvant chemotherapy.
  
  
  CONCLUSIONS
  Several clinicopathological factors including patient conditions and perioperative events were associated with failure to complete adjuvant chemotherapy.
authors: Department of Surgery, Nara Medical University, 840 Shijo-cho, Nara, 634-8522, Japan.
authors: Takahiro
authors: T
authors: Akahori
authors: Department of Surgery, Nara Medical University, 840 Shijo-cho, Nara, 634-8522, Japan. Electronic address: m-sho@naramed-u.ac.jp.
authors: Masayuki
authors: M
authors: Sho
authors: Department of Radiology, Nara Medical University, Nara, Japan.
authors: Toshihiro
authors: T
authors: Tanaka
authors: Department of Surgery, Nara Medical University, 840 Shijo-cho, Nara, 634-8522, Japan.
authors: Shoichi
authors: S
authors: Kinoshita
authors: Department of Surgery, Nara Medical University, 840 Shijo-cho, Nara, 634-8522, Japan.
authors: Minako
authors: M
authors: Nagai
authors: Department of Surgery, Nara Medical University, 840 Shijo-cho, Nara, 634-8522, Japan.
authors: Satoshi
authors: S
authors: Nishiwada
authors: Department of Radiology, Nara Medical University, Nara, Japan.
authors: Hideyuki
authors: H
authors: Nishiofuku
authors: Department of Diagnostic Pathology, Nara Medical University, Nara, Japan.
authors: Chiho
authors: C
authors: Ohbayashi
authors: Department of Radiology, Nara Medical University, Nara, Japan.
authors: Kimihiko
authors: K
authors: Kichikawa
authors: Department of Surgery, Nara Medical University, 840 Shijo-cho, Nara, 634-8522, Japan.
authors: Yoshiyuki
authors: Y
authors: Nakajima
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001803:Blood Transfusion / Q000706:statistics & numerical data; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009752:Nutritional Status; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology
keywords: Adjuvant chemotherapy; Pancreatic cancer; Prognosis; Recurrence