title: Salusin-β as a powerful endogenous antidipsogenic neuropeptide.
abstract: Salusin-β is an endogenous parasympathomimetic peptide, predominantly localized to the hypothalamus and posterior pituitary. Subcutaneously administered salusin-β (50 nmol/mouse) significantly increased water intake but did not affect locomotor activity or food intake. The salusin-β-induced increase in water intake was completely abrogated by pretreatment with muscarinic antagonist, atropine sulphate. In contrast, intracerebroventricular injection of salusin-β, at lower doses (10-100 fmol/mouse) caused a long-lasting decrease in water intake and locomotor activity throughout the entire dark phase of the diurnal cycle. Pre-injection of intracerebroventricular anti-salusin-β IgG completely abrogated the central salusin-β mediated suppression of water intake and locomotor activity. These results demonstrate contrasting actions of salusin-β in the control of water intake via the central and peripheral systems and highlight it as a potent endogenous antidipsogenic neuropeptide.
authors: Department of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine, Kanagawa 252-0374, Japan.|Tokyo Medical and Dental University Graduate School, Tokyo 113-8519, Japan.
authors: Noriko
authors: N
authors: Suzuki-Kemuriyama
authors: Tokyo Medical and Dental University Graduate School, Tokyo 113-8519, Japan.
authors: Tae
authors: T
authors: Nakano-Tateno
authors: Department of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine, Kanagawa 252-0374, Japan.
authors: Yuji
authors: Y
authors: Tani
authors: Institute of Biomedical Research and Innovation Hospital, Hyogo, Japan.
authors: Yukio
authors: Y
authors: Hirata
authors: Department of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine, Kanagawa 252-0374, Japan.
authors: Masayoshi
authors: M
authors: Shichiri
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000652:urine; D001522:Behavior, Animal / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009479:Neuropeptides / Q000008:administration & dosage / Q000494:pharmacology*; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood / Q000652:urine; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000097:blood / Q000652:urine
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D009479:Neuropeptides; C478739:TOR2A protein, human; D001127:Arginine Vasopressin; D012964:Sodium; D011188:Potassium