title: [Influence of GABA(C)-Receptor Antagonist on Formation of Evoked Potentials in Columns of the Rat Somatosensory Cortex].
abstract: Microelectrode studies of evoked potentials (EP) in neuronal column of rats barrel cortex show activating action of selective GABA(C)-receptor antagonist 1,2,5,6-tetrahydropyridin-4-yl-methylphosphinic acid (TPMPA) mainly on secondary components of EP of supragranular afferent layers of column compared to the efferent infragranular layers. These data suggest localization of GABA(C)-receptors on pre- synaptic terminals of thalamo-cortical glutamatergic afferents and ascending apical dendrites of pyramidal cells. A blockade of GABA(C)-receptors with the selective antagonist TPM PA leads to dose-dependent afferent depolarization with development of presynaptic inhibition and suppression of primary components of EP GABA(C)-receptors blocker produces different effects on secondary components of EP in supragranular layers of the cortex caused by the development of neuronal after hyperpolarization followed by high-amplitude primary response and afterdepolarization followed by low-amplitude primary responses with subsequent activation of different voltage-gated channels and formation of different level of cortical direct current potential gradients.
authors: A E
authors: AE
authors: Matukhno
authors: L V
authors: LV
authors: Lysenko
authors: Y V
authors: YV
authors: Andreeva
authors: A G
authors: AG
authors: Sukhov
mesh_terms: D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology*; D058787:GABA-A Receptor Antagonists / Q000008:administration & dosage; D059330:GABAergic Neurons / Q000187:drug effects / Q000502:physiology*; D010721:Phosphinic Acids / Q000008:administration & dosage; D024642:Potassium Channels, Voltage-Gated / Q000378:metabolism; D011725:Pyridines / Q000008:administration & dosage; D051381:Rats; D018079:Receptors, GABA / Q000378:metabolism*; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: C101879:(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid; D058787:GABA-A Receptor Antagonists; C087200:GABA-C receptor; D010721:Phosphinic Acids; D024642:Potassium Channels, Voltage-Gated; D011725:Pyridines; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid