title: T-Cell-Mediated Inflammatory Myopathies in HIV-Positive Individuals: A Histologic Study of 19 Cases.
abstract: T cell-mediated inflammatory myopathies (polymyositis [PM] and inclusion body myositis [IBM]) sometimes arise in conjunction with HIV infection; however, it is not understood whether PM and IBM arising in the context of HIV (HIV-PM and HV-IBM) differ from PM and IBM arising sporadically in HIV-negative individuals (sPM and sIBM). Here, we report the largest series of T cell-mediated inflammatory myopathies from HIV-infected patients (19 biopsies from 15 subjects); 5 cases were pathologically classified as PM (HIV-PM) and 14 as IBM (HIV-IBM). As with sporadic cases, quantitative immunohistochemistry for LC3, p62, and TDP-43 showed significantly greater percentage of stained fibers (% FS) in HIV-IBM compared to HIV-PM samples; however, there was no significant difference in % FS for any of the three markers between HIV-associated and sporadic cases. Despite histologic similarities between HIV-IBM and sIBM but in concordance with prior case reports, patients with HIV-IBM were significantly younger at diagnosis than patients with sIBM; in contrast, the mean age of HIV-PM and sPM patients was not significantly different. In summary, HIV-PM and HIV-IBM are morphologically similar to sPM and sIBM; thus, it remains unclear why patients with HIV-IBM, in contrast to patients with sIBM, sometimes show clinical improvement in response to immunosuppressive therapy.
authors: From the Department of Pathology, University of California San Francisco, San Francisco, California.
authors: Annie
authors: A
authors: Hiniker
authors: From the Department of Pathology, University of California San Francisco, San Francisco, California.
authors: Brianne H
authors: BH
authors: Daniels
authors: From the Department of Pathology, University of California San Francisco, San Francisco, California. marta.margeta@ucsf.edu.
authors: Marta
authors: M
authors: Margeta
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D018979:Myositis, Inclusion Body / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D017285:Polymyositis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D016601:RNA-Binding Proteins / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; C477012:MAP1LC3A protein, human; D008869:Microtubule-Associated Proteins; C118585:P62 protein, human; D016601:RNA-Binding Proteins; C000598624:TARDBP protein, human
keywords: HIV; Inclusion body myositis; LC3; Polymyositis; TDP-43.; p62