title: Nipple-sparing Mastectomy in Patients with Preoperative Diagnosis of Non-invasive Breast Carcinoma. A Single-center Experience.
abstract: BACKGROUND
  Nipple-sparing mastectomy (NSM) is a recognized treatment for selected patients with breast cancer (BC). Our study aimed to analyze 7 years' experience in NSM and breast reconstruction for patients with preoperative diagnosis of non-invasive BC.
  
  
  METHODS
  All NSMs with breast reconstruction, performed between January 2007 and December 2013 in patients with preoperative diagnosis of non-invasive BC, were considered.
  
  
  RESULTS
  Thirty-five NSMs were performed, 23 cases confirming the diagnosis of non-invasive BC, and in 12 patients it also resulted in findings of an invasive component. Patients were stratified into two groups: breast reconstruction was performed i) with silicone definitive implant, ii) with a temporary breast tissue expander. An invasive component at the postoperative histological examination was significantly associated with tissue expander reconstruction (p=0.03).
  
  
  CONCLUSIONS
  In selected cases, NSM is a valid and safe procedure. Further critical evaluations are required for more evidence on this argument.
authors: Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy marida.amabile@gmail.com.
authors: Maria Ida
authors: MI
authors: Amabile
authors: Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
authors: Massimo
authors: M
authors: Monti
authors: Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
authors: Raffaele
authors: R
authors: Merola
authors: Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
authors: Federico
authors: F
authors: Frusone
authors: Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy Department of General Microsurgery and Hand Surgery, Fabia Mater Hospital, Rome, Italy.
authors: Valerio
authors: V
authors: D'Orazi
authors: Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
authors: Vittorio
authors: V
authors: Pasta
mesh_terms: D000328:Adult; D019928:Breast Implantation / Q000295:instrumentation; D018427:Breast Implants; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008408:Mastectomy / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009558:Nipples / Q000601:surgery*; D011474:Prosthesis Design; D012189:Retrospective Studies; D012384:Rome; D012828:Silicones; D013997:Time Factors; D015626:Tissue Expansion / Q000295:instrumentation; D015625:Tissue Expansion Devices; D016896:Treatment Outcome
chemical_list: D012828:Silicones
keywords: Nipple-sparing mastectomy; breast reconstruction; non-invasive breast cancer