title: The enhancement of immune function and activation of NF-κB by resveratrol-treatment in immunosuppressive mice.
abstract: Resveratrol, a kind of natural product found in over 70 plants, possesses both immunomodulatory and anticancer effects. Many reports have shown that resveratrol has the bidirectional regulation effects on antigen presenting and cellular immunity. However, few reports have evaluated the effects of resveratrol on reinforcing immunity recovery via activating nuclear factor -κappa B (NF-κB). In the present study, we investigated the effects of resveratrol on recovery and reconstruction of immune function by detecting nonspecific and specific immunity in immunosuppressive mice. We found that, compared to the immunosuppressive mice, the spleen index and spleen lymphocyte proliferation of resveratrol-treated mice (30 mg/kg body weight) were enhanced. After resveratrol-treatment (15 mg/kg body weight), the function of peritoneal macrophages was enhanced and the CD4+ cells were increased in peripheral blood. The expressions of serum cytokines related to immune function, including interleukin (IL)-1α/β, IL-2, tumor necrosis factor-α and NF-κB were up-regulated in a dose-dependent manner. The expression of the transcription factor NF-κB in spleen was enhanced after resveratrol-treatment. The immuno-enhancement effects of resveratrol were similar to that of levamisole (served as positive control). These results demonstrated that resveratrol had potent immune enhancement activity in immunosuppressive mice, and one possible mechanism of action was to activate the NF-κB.
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors: Xin
authors: X
authors: Lai
authors: Qinghai Academy of Animal Science and Veterinary Medicine, Xining 810016, China.
authors: Qingsheng
authors: Q
authors: Pei
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors: Xu
authors: X
authors: Song
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors: Xun
authors: X
authors: Zhou
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address: yinzhongq@163.com.
authors: Zhongqiong
authors: Z
authors: Yin
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130,China.
authors: Renyong
authors: R
authors: Jia
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors: Yuanfeng
authors: Y
authors: Zou
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors: Lixia
authors: L
authors: Li
authors: College of Veterinary Science, Sichuan Agricultural University, Chengdu 611130, China.
authors: Guizhou
authors: G
authors: Yue
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors: Xiaoxia
authors: X
authors: Liang
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors: Lizi
authors: L
authors: Yin
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors: Cheng
authors: C
authors: Lv
authors: Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
authors: Bo
authors: B
authors: Jing
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007109:Immunity / Q000187:drug effects; D007114:Immunization; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D013267:Stilbenes; D000077185:Resveratrol
keywords: Immune function; Immunosuppressive mice; NF-κB; Resveratrol