title: Distribution of toxic chemicals in particles of various sizes from mainstream cigarette smoke.
abstract: To accurately estimate the risk of inhaling cigarette smoke containing toxic chemicals, it is important that the distribution of these chemicals is accurately measured in cigarette smoke aerosol particles of various sizes. In this study, a single-channel smoking machine was directly coupled to an electrical low-pressure impactor. The particles of mainstream cigarette smoke were collected using 12 polyester films, and the particulate matter (PM) was characterized. Nicotine, tobacco-specific N-nitrosamines (TSNAs, including NNN, NAT, NAB, and NNK), polycyclic aromatic hydrocarbons (PAHs, including benzo(a)pyrene (BaP), benzo(a)anthracene, and chrysene), and heavy metals (including Cr, As, Cd, and Pb) present in the particles of different sizes were analyzed by GC, HPLC-MS/MS, GC/MS, or ICP-MS, respectively. The results demonstrated that the nicotine, TSNAs, PAHs, and heavy metals in mainstream cigarette smoke were dispersed over a particle size ranging from 0.1 μm to 2.0 μm, and the concentration of these toxic chemicals initially increased and then decreased the particle size grew. The distribution of nicotine was uniform for the PM in the size ranges of less than 0.1 μm, 0.1-1.0 μm, and 1.0-2.0 μm, TSNAs and heavy metals in particles of less 0.1 μm were more abundant, and PAHs in fine particles were also more abundant.
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Hongbo
authors: H
authors: Wang
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Xiang
authors: X
authors: Li
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Junwei
authors: J
authors: Guo
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Bin
authors: B
authors: Peng
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Huapeng
authors: H
authors: Cui
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Kejian
authors: K
authors: Liu
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Sheng
authors: S
authors: Wang
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Yaqiong
authors: Y
authors: Qin
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Peijian
authors: P
authors: Sun
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Le
authors: L
authors: Zhao
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Fuwei
authors: F
authors: Xie
authors: a Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , China.
authors: Huimin
authors: H
authors: Liu
mesh_terms: D019216:Metals, Heavy / Q000737:chemistry; D009538:Nicotine / Q000737:chemistry; D010316:Particle Size; D052638:Particulate Matter / Q000737:chemistry*; D012906:Smoke / Q000032:analysis*; D062789:Tobacco Products / Q000032:analysis*
chemical_list: D019216:Metals, Heavy; D052638:Particulate Matter; D012906:Smoke; D009538:Nicotine
keywords: mainstream cigarette smoke; nicotine; particle size; particulate matter; toxic chemicals