title: Augmentation of the Inotropic Effects of Dopamine Following Linezolid Administration in an Infant.
abstract: Although generally safe and effective, one of the unique properties of linezolid is its weak inhibitory effect on monoamine oxidase. As such, it may interact with other medications that act through the adrenergic or serotonergic systems, including selective-serotonin reuptake inhibitors and vasoactive agents. We present a 3-month-old infant who was being treated with dopamine to maintain mean arterial pressure during mechanical ventilation following viral-induced respiratory failure. Hypertension and tachycardia developed during the administration of linezolid on two separate occasions. The physiology of catecholamine metabolism is reviewed including the role of the monoamine oxidase system. The potential interaction between linezolid and vasoactive agents such as dopamine is discussed.
authors: Division of Pediatric Critical Care, Nationwide Children's Hospital, Columbus, OH, USA Marlina.Lovett@Nationwidechildrens.org.
authors: Marlina E
authors: ME
authors: Lovett
authors: Division of Pediatric Critical Care, Nationwide Children's Hospital, Columbus, OH, USA Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.
authors: Maria
authors: M
authors: Estrada
authors: Department of Pharmacy, Nationwide Children's Hospital, Columbus, OH, USA.
authors: Cheryl
authors: C
authors: Sargel
authors: Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA Department of Anesthesiology & Pain Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.
authors: Joseph D
authors: JD
authors: Tobias
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004298:Dopamine / Q000008:administration & dosage*; D004347:Drug Interactions; D004769:Enterovirus Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D007442:Intubation, Intratracheal / Q000009:adverse effects; D000069349:Linezolid / Q000008:administration & dosage*; D010850:Picornaviridae Infections / Q000150:complications / Q000188:drug therapy*; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000209:etiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D013771:Tetralogy of Fallot; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D004298:Dopamine; D000069349:Linezolid; D017367:Selective Serotonin Reuptake Inhibitors; D014640:Vancomycin
keywords: dopamine; hypertension; inotropic agents; linezolid; monoamine oxidase