title: Does vitamin D supplementation alleviate chronic nonspecific musculoskeletal pain? A systematic review and meta-analysis.
abstract: Chronic nonspecific musculoskeletal pain (CNMP) is an idiopathic condition often seen in general practice and rheumatology clinics, the aetiology of which may include vitamin D deficiency. The objective of the present study is to evaluate the effectiveness of vitamin D supplementation in the management of CNMP through a systematic review and meta-analysis. According to PRISMA guidelines, PubMed, Embase, Web of Science, Cochrane and Scopus electronic databases were searched for randomised controlled trials comparing vitamin D supplementation to a control or placebo in CNMP patients; the search was not limited by language or date. Meta-analysis was performed using the mean and standardised mean difference which was computed with 95 % confidence intervals, and overall effect size was calculated. Both fixed and random effects models were used in meta-analysis to account for heterogeneity in the studies. The initial search identified 107 studies, of which 10 were potentially relevant, with 7 studies excluded because they did not meet selection criteria. Three studies were included in the meta-analysis. We found no effect of vitamin D supplementation (standardised mean difference (SMD) 0.004; 95 % confidence interval (CI) -0.248 to 0.256) on pain in CNMP patients. Forest plot is used to present the results from meta-analysis. Contrary to a widespread clinical view, there is a moderate level of evidence that vitamin D supplementation is not helpful for treating CNMP patients.
authors: Discipline of General Practice, School of Medicine, University of Adelaide, Level 11, Terrace Towers, 178 North Terrace, Adelaide, 5005, Australia. manasi.gaikwad@adelaide.edu.au.
authors: M
authors: M
authors: Gaikwad
authors: Discipline of General Practice, School of Medicine, University of Adelaide, Level 11, Terrace Towers, 178 North Terrace, Adelaide, 5005, Australia.
authors: S
authors: S
authors: Vanlint
authors: School of Public Health, University of Adelaide, Level 7, Terrace Towers, 178 North Terrace, Adelaide, 5005, Australia.
authors: M
authors: M
authors: Mittinity
authors: Sansom Institute for Health Research, University of South Australia, Centenary Building C5-7, City East Campus, Adelaide, 5000, Australia.
authors: G L
authors: GL
authors: Moseley
authors: Discipline of General Practice, School of Medicine, University of Adelaide, Level 11, Terrace Towers, 178 North Terrace, Adelaide, 5005, Australia.
authors: N
authors: N
authors: Stocks
mesh_terms: D002908:Chronic Disease; D019587:Dietary Supplements; D006801:Humans; D059352:Musculoskeletal Pain / Q000188:drug therapy*; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D014815:Vitamins; D014807:Vitamin D
keywords: Chronic nonspecific musculoskeletal pain; Meta-analysis; Systematic review; Vitamin D; Vitamin D supplementation