title: Dynamics of nasopharyngeal pneumococcal carriage during the course of viral bronchiolitis.
abstract: The effect of viral infection on nasopharyngeal carriage of Streptococcus pneumoniae during childhood is not well known. We studied dynamics of pneumococcal colonization by quantitative PCR during the natural course of viral bronchiolitis. At time of admission, 47 (47%) of 100 patients with bronchiolitis carried pneumococci. In patients with viral bronchiolitis who did not receive antibiotics, pneumococcal load decreased from time of admission to discharge (n = 35, cycle threshold 23 vs. 25, P = 0.0017) and from discharge to follow-up (n = 22, cycle threshold 25 vs. 40, P = 0.003). We conclude that viral respiratory infection is negatively associated with pneumococcal colonization of the upper airways. Pediatr Pulmonol. 2016;51:863-867. © 2016 Wiley Periodicals, Inc.
authors: Department of Pediatrics, Medical Center Leeuwarden, P.O. Box 888, 8901 BR, Leeuwarden, The Netherlands.
authors: Tina E
authors: TE
authors: Faber
authors: Center for Medical Microbiology and Infectious Diseases, Izore, Leeuwarden, The Netherlands.
authors: Theo A
authors: TA
authors: Schuurs
authors: Department of Epidemiology, University Medical Center Groningen, The Netherlands.
authors: Nic J G M
authors: NJ
authors: Veeger
authors: Department of Pediatric Intensive Care, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands.
authors: Marije P
authors: MP
authors: Hennus
authors: Department of Pediatrics and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands.
authors: Louis J
authors: LJ
authors: Bont
mesh_terms: D058491:Bacterial Load; D001990:Bronchiolitis, Viral / Q000150:complications / Q000382:microbiology*; D002353:Carrier State / Q000382:microbiology*; D060085:Coinfection; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000150:complications / Q000382:microbiology*; D011446:Prospective Studies; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*
keywords: Streptococcus pneumoniae; nasopharyngeal carriage; respiratory syncytial virus