title: Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced Sepsis.
abstract: Sepsis caused by Staphylococcus aureus is increasing in incidence. With the alarming use of antibiotics,S. aureus is prone to become methicillin resistant. Antibiotics are the only widely used pharmacological treatment for sepsis. Interestingly, mice fed high-fat diet (HFD) rich in polyunsaturated fatty acids have better survival of S. aureus-induced sepsis than mice fed HFD rich in saturated fatty acids (HFD-S). To investigate what component of polyunsaturated fatty acids, i.e., omega-3 or omega-6 fatty acids, exerts beneficial effects on the survival of S. aureus-induced sepsis, mice were fed HFD rich in omega-3 or omega-6 fatty acids for 8 weeks prior to inoculation with S. aureus Further, mice fed HFD-S were treated with omega-3 fatty acid metabolites known as resolvins. Mice fed HFD rich in omega-3 fatty acids had increased survival and decreased bacterial loads compared to those for mice fed HFD-S after S. aureus-induced sepsis. Furthermore, the bacterial load was decreased in resolvin-treated mice fed HFD-S after S. aureus-induced sepsis compared with that in mice treated with vehicle. Dietary omega-3 fatty acids increase the survival of S. aureus-induced sepsis by reversing the deleterious effect of HFD-S on mouse survival.
authors: Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden.
authors: Sara L
authors: http://orcid.org/0000-0003-2614-1138
authors: SL
authors: Svahn
authors: Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden.
authors: Marcus A
authors: MA
authors: Ulleryd
authors: Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden.|Department of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors: Louise
authors: L
authors: Grahnemo
authors: Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors: Marcus
authors: M
authors: Ståhlman
authors: Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors: Jan
authors: J
authors: Borén
authors: Department of Mathematical Statistics, Chalmers University of Technology, Gothenburg, Sweden.
authors: Staffan
authors: S
authors: Nilsson
authors: Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden.
authors: John-Olov
authors: JO
authors: Jansson
authors: Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden maria.e.johansson@neuro.gu.se.
authors: Maria E
authors: ME
authors: Johansson
mesh_terms: D000273:Adipose Tissue; D000818:Animals; D058491:Bacterial Load / Q000187:drug effects*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology*; D007249:Inflammation / Q000378:metabolism; D051379:Mice; D011897:Random Allocation; D018805:Sepsis / Q000178:diet therapy / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000178:diet therapy* / Q000382:microbiology; D013211:Staphylococcus aureus
chemical_list: D016207:Cytokines; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3