title: Predictors of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma: a case report.
abstract: We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseline characteristics of this IRIS-KS case, within a cohort of 12 naïve AIDS-KS patients, were analyzed. No statistically significant differences in CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load in peripheral blood mononuclear cells and saliva were evidenced. HHV8 load in plasma was found to be significantly higher in the KS-IRIS patient (> 6 log10 genome equivalents/ml, p = 0.01, t-test) compared to the 11 patients with KS regression. This case highlights that measurement of HHV8 load in plasma may be useful to identify patients at risk for KS-IRIS, and that this parameter should be included in the design of larger studies to define KS-IRIS risk predictors.
authors: Infectious and Tropical Diseases, Azienda Ospedaliera and University of Padova, Padova, Italy.
authors: Anna Maria
authors: AM
authors: Cattelan
authors: Immunology and Molecular Oncology, Veneto Institute of Oncology, IOV IRCCS, Padova, Italy.
authors: Adriana
authors: A
authors: Mattiolo
authors: Immunology and Molecular Oncology, Veneto Institute of Oncology, IOV IRCCS, Padova, Italy.
authors: Angela
authors: A
authors: Grassi
authors: Immunology and Molecular Oncology, Veneto Institute of Oncology, IOV IRCCS, Padova, Italy.
authors: Maria Assunta
authors: MA
authors: Piano
authors: Infectious Diseases, ULSS 18 - Azienda Ospedaliera, Rovigo, Italy.
authors: Lolita
authors: L
authors: Sasset
authors: Department of Infectious and Tropical Diseases, University of Padova, School of Medicine, Padova, Italy.
authors: Marco
authors: M
authors: Trevenzoli
authors: Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
authors: Paola
authors: P
authors: Zanovello
authors: Immunology and Molecular Oncology, Veneto Institute of Oncology, IOV IRCCS, Padova, Italy.
authors: Maria Luisa
authors: ML
authors: Calabrò
keywords: Biomarker; HHV8; IRIS; Immune reconstitution inflammatory syndrome; KS; KS-IRIS; KSHV; Kaposi’s sarcoma