title: Inkjet deposition of itraconazole onto poly(glycolic acid) microneedle arrays.
abstract: Poly(glycolic acid) microneedle arrays were fabricated using a drawing lithography process; these arrays were modified with a drug release agent and an antifungal agent by piezoelectric inkjet printing. Coatings containing poly(methyl vinyl ether-co-maleic anhydride), a water-soluble drug release layer, and itraconazole (an antifungal agent), were applied to the microneedles by piezoelectric inkjet printing. Microscopic evaluation of the microneedles indicated that the modified microneedles contained the piezoelectric inkjet printing-deposited agents and that the surface coatings were released in porcine skin. Energy dispersive x-ray spectrometry aided in confirmation that the piezoelectric inkjet printing-deposited agents were successfully applied to the desired target areas of the microneedle surface. Fourier transform infrared spectroscopy was used to confirm the presence of the component materials in the piezoelectric inkjet printing-deposited material. Itraconazole-modified microneedle arrays incubated with agar plates containing Candida albicans cultures showed zones of growth inhibition.
authors: Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Box 7115, Raleigh, North Carolina 27695.
authors: Ryan D
authors: RD
authors: Boehm
authors: Department of Material Science Engineering, North Carolina State University, Box 7907, Raleigh, North Carolina 27695.
authors: Panupong
authors: P
authors: Jaipan
authors: Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Box 7115, Raleigh, North Carolina 27695.
authors: Shelby A
authors: SA
authors: Skoog
authors: Center for Nanoscale Science and Engineering, North Dakota State University, 1805 Research Park Drive, Fargo, North Dakota 58102.
authors: Shane
authors: S
authors: Stafslien
authors: Center for Nanoscale Science and Engineering, North Dakota State University, 1805 Research Park Drive, Fargo, North Dakota 58102.
authors: Lyndsi
authors: L
authors: VanderWal
authors: Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Box 7115, Raleigh, North Carolina 27695 and Department of Material Science Engineering, North Carolina State University, Box 7907, Raleigh, North Carolina 27695.
authors: Roger J
authors: RJ
authors: Narayan
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D017964:Itraconazole / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D011100:Polyglycolic Acid / Q000737:chemistry*; D012867:Skin / Q000737:chemistry; D013552:Swine
chemical_list: D000935:Antifungal Agents; D004337:Drug Carriers; D011100:Polyglycolic Acid; D017964:Itraconazole