title: Chelation-assisted Pd-catalysed ortho-selective oxidative C-H/C-H cross-coupling of aromatic carboxylic acids with arenes and intramolecular Friedel-Crafts acylation: one-pot formation of fluorenones.
abstract: Pd-Catalysed ortho-selective oxidative C-H/C-H cross-coupling of aromatic carboxylic acids with arenes and subsequent intramolecular Friedel-Crafts acylation has been accomplished for the first time through a chelation-assisted C-H activation strategy. Starting from the readily available substrates, a variety of fluorenone derivatives are obtained in one pot. The direct use of naturally occurring carboxylic acid functionalities as directing groups avoids unnecessary steps for installation and removal of an extra directing group.
authors: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China. jingbolan@scu.edu.cn jsyou@scu.edu.cn.
authors: Denan
authors: D
authors: Sun
authors: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China. jingbolan@scu.edu.cn jsyou@scu.edu.cn.
authors: Bijin
authors: B
authors: Li
authors: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China. jingbolan@scu.edu.cn jsyou@scu.edu.cn.
authors: Jingbo
authors: J
authors: Lan
authors: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China. jingbolan@scu.edu.cn jsyou@scu.edu.cn.
authors: Quan
authors: Q
authors: Huang
authors: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China. jingbolan@scu.edu.cn jsyou@scu.edu.cn.
authors: Jingsong
authors: J
authors: You
mesh_terms: D000215:Acylation; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D002614:Chelating Agents / Q000737:chemistry*; D005449:Fluorenes / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D002614:Chelating Agents; D005449:Fluorenes; D010165:Palladium