title: The evaluation of uterine artery embolization as a nonsurgical treatment option for adenomyosis.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of uterine artery embolization (UAE) for the treatment of adenomyosis.
  
  
  METHODS
  A prospective study was performed at Yuhuangding Hospital, China, between January 2012 and December 2013, enrolling premenopausal patients diagnosed with adenomyosis. All patients were treated with bilateral UAE using 500-700-μm tris-acryl gelatin microspheres. At baseline, and 3, 6, and 12months after UAE, magnetic resonance imaging was used to assess uterine volume and patient-assessed improvements in dysmenorrhea were recorded. Any complications and adverse events were reported.
  
  
  RESULTS
  In total, 117 patients with adenomyosis were enrolled. The bilateral UAE procedure was successful in 115 (98.3%) patients, who were able to return to normal activity within 1week of treatment. At 12-month follow-up, a median 51.0% reduction in uterine volume from baseline was recorded (P=0.005). Marked and moderate improvements in dysmenorrhea symptoms were reported by 64 (55.7%) and 31 (27.0%) participants, respectively. Pelvic pain of varying intensity was reported by 112 (97.4%) patients but was managed with analgesia. Persistent amenorrhea was experienced by 2 (1.7%) individuals following treatment. Patients did not encounter any new gynecologic or general complications following UAE treatment.
  
  
  CONCLUSIONS
  UAE could be considered as a minimally invasive treatment option for patients with adenomyosis. Further research to compare the efficacy and safety of UAE with conventional hysterectomy is warranted.
authors: Department of Gynecology, Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, China. Electronic address: shaoguangwang2@sina.com.
authors: Shaoguang
authors: S
authors: Wang
authors: Department of Gynecology, Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, China.
authors: Xiaomei
authors: X
authors: Meng
authors: Department of Gynecology, Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, China.
authors: Yaozhong
authors: Y
authors: Dong
mesh_terms: D000180:Acrylic Resins / Q000627:therapeutic use*; D062788:Adenomyosis / Q000473:pathology / Q000628:therapy*; D000328:Adult; D002681:China; D004412:Dysmenorrhea / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005780:Gelatin / Q000627:therapeutic use*; D006801:Humans; D007902:Length of Stay; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010147:Pain Measurement; D017699:Pelvic Pain / Q000209:etiology; D011446:Prospective Studies; D016896:Treatment Outcome; D055357:Uterine Artery Embolization; D014599:Uterus / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D000180:Acrylic Resins; C496735:trisacryl gelatin microspheres; D005780:Gelatin
keywords: Adenomyosis; Dysmenorrhea; Embolization; Uterine artery