title: Research consent capacity varies with executive function and memory in Parkinson's disease.
abstract: BACKGROUND
  We examined the association between cognitive domains and research consent capacity in PD. Our hypothesis was that research consent capacity is best predicted by executive function.
  
  
  METHODS
  A cohort of 90 PD patients and 30 healthy older adults were administered the MacArthur Competence Assessment Tool for Clinical Research, Dementia Rating Scale-2, and the MoCA. Experts classified patients as either "capable" or "not capable" of providing informed consent to participate in two clinical trials.
  
  
  RESULTS
  MacArthur Competence Assessment Tool for Clinical Research Reasoning scores for both clinical trial types were most associated with executive functions and delayed recall. As scores on these domains improved, the odds of an expert rating of "capable of consent" increased.
  
  
  CONCLUSIONS
  These results extend our previous findings by demonstrating that memory and executive abilities appear closely associated with capacity when evaluated using either a structured interview or expert judgment of that interview.
authors: Department of Behavioral and Social Sciences, University of the Sciences, Philadelphia, Pennsylvania, USA.
authors: Stephen T
authors: ST
authors: Moelter
authors: Parkinson's Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.|Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.|Department of Psychiatry, Geriatric Psychiatry Section, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Daniel
authors: D
authors: Weintraub
authors: Department of Behavioral and Social Sciences, University of the Sciences, Philadelphia, Pennsylvania, USA.
authors: Lauren
authors: L
authors: Mace
authors: Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Mark
authors: M
authors: Cary
authors: Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Elizabeth
authors: E
authors: Sullo
authors: Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Sharon X
authors: SX
authors: Xie
authors: Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.|Department of Medical Ethics and Health Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.|Leonard Davis Institute of Health Economics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.|Alzheimer's Disease Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Jason
authors: J
authors: Karlawish
mesh_terms: D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology*; D003657:Decision Making / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D012106:Research
keywords: Parkinson's disease; capacity; cognitive impairment; decision making; informed consent