title: Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.
abstract: This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites contract synchronously, facilitating the use of this tissue-engineering platform to study structure-function relationships in the heart.
authors: Laboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.|College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
authors: Benjamin W
authors: BW
authors: Lee
authors: Laboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.|College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
authors: Bohao
authors: B
authors: Liu
authors: Laboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
authors: Adam
authors: A
authors: Pluchinsky
authors: Laboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
authors: Nathan
authors: N
authors: Kim
authors: Laboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.|College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
authors: George
authors: G
authors: Eng
authors: Laboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.|Department of Medicine (in Medical Sciences), Columbia University, New York, NY, 10032, USA.
authors: Gordana
authors: G
authors: Vunjak-Novakovic
mesh_terms: D000818:Animals; D016880:Anisotropy; D042783:Endothelial Cells / Q000166:cytology; D004730:Endothelium, Vascular / Q000502:physiology; D006321:Heart / Q000033:anatomy & histology*; D055616:Microtechnology; D032383:Myocytes, Cardiac / Q000166:cytology; D018919:Neovascularization, Physiologic; D051381:Rats; D023822:Tissue Engineering / Q000379:methods*
keywords: anisotropy; cardiac tissue engineering; hydrogels; micropatterning; modular assembly