title: Modulation of the antibiotic activity against multidrug resistant strains of 4-(phenylsulfonyl) morpholine.
abstract: The compound 4-(Phenylsulfonyl) morpholine belongs to the class of sulfonamides, which are widely used in the treatment of a large number of diseases caused by microorganisms. This compound has a morpholine group, which is also known for its antimicrobial properties. The aim of the present study was to investigate the antimicrobial and modulating activity of 4-(Phenylsulfonyl) morpholine against standard and multi-resistant strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and strains of the fungi Candida albicans, C. tropicalis and C. krusei. Antimicrobial activity was assessed based on the minimum inhibitory concentration (MIC) using the microdilution method. MIC was ⩾1024 μg/mL for all microorganisms. Regarding modulating activity, the most representative effect occurred with the combination of 4-(Phenylsulfonyl) morpholine at a concentration of 128 μg/mL (MIC 1/8) and amikacin against P. aeruginosa 03, with a reduction in MIC from 312.5 to 39.06 μg/mL.
authors: Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
authors: Maria T A
authors: MT
authors: Oliveira
authors: Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
authors: Alexandre M R
authors: AM
authors: Teixeira
authors: Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
authors: Cícera J M
authors: CJ
authors: Cassiano
authors: Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
authors: Diniz M
authors: DM
authors: Sena
authors: Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
authors: Henrique D M
authors: HD
authors: Coutinho
authors: Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
authors: Irwin R A
authors: IR
authors: Menezes
authors: Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
authors: Fernando G
authors: FG
authors: Figueredo
authors: Setor Litoral - Universidade Federal do Paraná, Matinhos, PR, Brazil.
authors: Luiz E
authors: LE
authors: Silva
authors: Universidade Federal de São Carlos, São Carlos, SP, Brazil.
authors: Thiago A
authors: TA
authors: Toledo
authors: Universidade Federal do Mato Grosso - UFMT, Cuiabá, MT, Brazil.
authors: Ricardo R F
authors: RR
authors: Bento
keywords: 4-(Phenylsulfonyl) morpholine; Antimicrobial agent; Microbial resistance; Modulation