title: Review article: Mucosa-associated lymphoid tissue (MALT)-type lymphoma of ocular adnexa. Biology and treatment.
abstract: Over the last decades, we have witnessed an increase in the incidence of primary ocular adnexa lymphomas (POALs) probably because advances in imaging techniques have enabled precise biopsies of the tumors. The ocular tissue biopsy, before the initiation of the appropriate treatment, is mandatory and necessary for a correct diagnosis of POALs by the use of immunophenotyping and a correct molecular classification. Only in a minority of cases the ocular adnexa are secondarily affected by a systemic disease. Among the POALs, the most common is the primary extra nodal lymphoma of MALT-type (POAML). POAML is rarely symptomatic in the early phase of the disease. As a consequence, often we see a delay in ophthalmic consultations and diagnosis. The clinical manifestations are heterogeneous and its management requires a multidisciplinary approach involving ophthalmologists, hematologists and radiotherapists.
authors: Area Ematologia Trapianto Cellule Staminali, Medicina Trasfusionale e Terapia Cellulare, Università Campus Bio-Medico Roma, Italy. Electronic address: o.annibali@unicampus.it.
authors: Ombretta
authors: O
authors: Annibali
authors: Area di Oculistica, Università Campus Bio-Medico di Roma, Italy.
authors: Francesco
authors: F
authors: Sabatino
authors: IRCCS Fondazione GB Bietti, Rome, Italy.
authors: Flavio
authors: F
authors: Mantelli
authors: Area Ematologia Trapianto Cellule Staminali, Medicina Trasfusionale e Terapia Cellulare, Università Campus Bio-Medico Roma, Italy.
authors: Odoardo Maria
authors: OM
authors: Olimpieri
authors: Area di Oculistica, Università Campus Bio-Medico di Roma, Italy.
authors: Stefano
authors: S
authors: Bonini
authors: Area Ematologia Trapianto Cellule Staminali, Medicina Trasfusionale e Terapia Cellulare, Università Campus Bio-Medico Roma, Italy.
authors: Giuseppe
authors: G
authors: Avvisati
mesh_terms: D005134:Eye Neoplasms; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone; D018294:Neoplasms, Adnexal and Skin Appendage
keywords: POALs (primary ocular adnexa lymphomas); POAML (primary ocular adnexa MALT lymphoma)