title: High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype.
abstract: The purpose of this study was to evaluate risk factors that influence overall survival (OS)/disease-free survival (DFS)/locoregional recurrence-free survival (LRFS), and distant metastases-free survival (DMFS) in patients with high-risk primary salivary gland carcinoma who underwent surgery and postoperative (chemo)radiotherapy with curative intention.
  
  
  
  We reviewed data of 63 patients with high-risk primary salivary gland carcinoma in a retrospective single-center audit.
  
  
  
  At a median follow-up of 31 months (range, 5-145 months), cumulative OS and DFS were 91.7%, 77.6%, and 62.9%, and 82.1%, 65.6%, and 57.7%, respectively, after 1, 2, and 5 years. LRFS and DMFS were 92%, 86%, and 86%, and 83.4%, 70.4%, and 62.3% after 1, 2, and 5 years, respectively. Of all patient-related, tumor-related, and treatment-related factors, high-grade histology (G3) was the only factor in univariate and multivariate analysis that was predictive for a shorter DMFS (low/intermediate vs high-grade: 100%, 100%, and 89.4% vs 72.9%, 54.3%, and 42.8% after 1, 2, and 5 years, respectively) and a shorter DFS (low/intermediate vs high-grade: 100%, 90%, and 84.4% vs 71.2%, 50.1%, and 39.4% after 1, 2, and 5 years, respectively) and OS (low/intermediate vs high-grade: 100%, 100%, and 86.5% vs 86.5%, 63.2%, and 46.5% after 1, 2, and 5 years, respectively).
  
  
  
  High-grade tumor histology is a highly significant predictor of a shorter DMFS, OS, and DFS in salivary gland carcinoma, irrespective of histological subtype. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2041-E2048, 2016.
authors: Department of Radiation Oncology, University Hospital of Erlangen, Erlangen, Germany.
authors: Marlen
authors: M
authors: Haderlein
authors: Department of Otorhinolaryngology, University Hospital of Erlangen, Erlangen, Germany.
authors: Claudia
authors: C
authors: Scherl
authors: Department of Radiation Oncology, University Hospital of Erlangen, Erlangen, Germany.
authors: Sabine
authors: S
authors: Semrau
authors: Department of Radiation Oncology, University Hospital of Erlangen, Erlangen, Germany.
authors: Sebastian
authors: S
authors: Lettmaier
authors: Department of Medical Informatics, Biometry and Epidemiology, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
authors: Wolfgang
authors: W
authors: Uter
authors: Department of Oral and Maxillofacial Surgery, University Hospital of Erlangen, Erlangen, Germany.
authors: Friedrich Wilhelm
authors: FW
authors: Neukam
authors: Department of Otorhinolaryngology, University Hospital of Erlangen, Erlangen, Germany.
authors: Heinrich
authors: H
authors: Iro
authors: Institute of Pathology, University Hospital of Erlangen, Erlangen, Germany.
authors: Abbas
authors: A
authors: Agaimy
authors: Department of Radiation Oncology, University Hospital of Erlangen, Erlangen, Germany.
authors: Rainer
authors: R
authors: Fietkau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate
keywords: chemotherapy; distant metastases; high-grade; radiotherapy; salivary gland cancer