title: Circulating anti-mullerian hormone as predictor of ovarian response to clomiphene citrate in women with polycystic ovary syndrome.
abstract: BACKGROUND
  To investigate the impact of high circulating AMH on the outcome of CC ovulation induction in women with PCOS.
  
  
  METHODS
  This prospective cohort observational study included 81 anovulatory women with PCOS who underwent 213 cycles of CC ovarian stimulation. Serum AMH concentrations were measured on cycle day 3 before the commencement of CC in the first cycle, which were compared between responders and CC-resistant anovulation (CRA). Logistic regression analysis was applied to study the value of serum AMH for the prediction of ovarian responsiveness to CC stimulation. The receiver-operating characteristic (ROC) curve was used to evaluate the prognostic value of circulating AMH.
  
  
  METHODS
  Serum AMH levels.
  
  
  RESULTS
  Women who ovulated after CC therapy had a significantly lower AMH compared with the CRA (5.34 ± 1.97 vs.7.81 ± 3.49, P < 0.001). There was a significant gradient increase of serum AMH levels with the increasing dose of CC required to achieve ovulation (P < 0.05). In multivariate logistic regression analysis, AMH was an independent predictor of ovulation induction by CC in PCOS patients. ROC curve analysis showed AMH to be a useful predictor of ovulation induction by CC in PCOS patients, having 92 % specificity and 65 % sensitivity when the threshold AMH concentration was 7.77 ng/ml.
  
  
  CONCLUSIONS
  Serum AMH may be clinically useful to predict which PCOS women are more likely to respond to CC treatment and thus to direct the selection of protocols of ovulation induction.
authors: Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xi'an City, 710004, Shaanxi Prov., China. yuedanxi@126.com.
authors: Wenyan
authors: W
authors: Xi
authors: Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang City, 712000, Shaanxi Prov., China. yongkangyang2015@163.com.
authors: Yongkang
authors: Y
authors: Yang
authors: Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xi'an City, 710004, Shaanxi Prov., China. xwyanzi@126.com.
authors: Hui
authors: H
authors: Mao
authors: Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xi'an City, 710004, Shaanxi Prov., China. xuexiang617@163.com.
authors: Xiuhua
authors: X
authors: Zhao
authors: Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xi'an City, 710004, Shaanxi Prov., China. radare@163.com.
authors: Ming
authors: M
authors: Liu
authors: Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xi'an City, 710004, Shaanxi Prov., China.
authors: Shengyu
authors: S
authors: Fu
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002996:Clomiphene / Q000627:therapeutic use*; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010053:Ovary / Q000187:drug effects; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy; D012372:ROC Curve; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004965:Estrogen Antagonists; D002996:Clomiphene; D054304:Anti-Mullerian Hormone