title: Effect of cisplatin containing liposomes formulated by unsaturated chain-containing lipids on gynecological tumor cells.
abstract: Gynecological tumors are major therapeutic areas of platinum-based anticancer drugs. Here, we report the characterization and in vitro biological assays of cisplatin-containing Egg L-α-phosphatidylcholine liposomes with different amounts of cholesterol. Dynamic light scattering estimated sizes of all obtained liposomes in the 100 nm range that are suitable for in vivo use. On the basis of these data and of the drug loading values, the best formulation has been selected. Stability and drug release properties of platinum-containing liposomes have been verified in serum. The growth inhibitory effects of both liposomal and free drug in a panel of ovarian and breast human cancer cell lines, characterized by a different drug sensitivity, give comparable or better results with respect to free cisplatin drug.
authors: a Department of Pharmacy and CIRPeB , University of Naples "Federico II" , Naples , Italy .
authors: Paola
authors: P
authors: Ringhieri
authors: b Istituto Di Biostrutture E Bioimmagini - CNR , Naples , Italy , and.
authors: Alessandra
authors: A
authors: Pannunzio
authors: b Istituto Di Biostrutture E Bioimmagini - CNR , Naples , Italy , and.
authors: Angelina
authors: A
authors: Boccarelli
authors: a Department of Pharmacy and CIRPeB , University of Naples "Federico II" , Naples , Italy .|b Istituto Di Biostrutture E Bioimmagini - CNR , Naples , Italy , and.
authors: Giancarlo
authors: G
authors: Morelli
authors: c Department of Pharmacy-Drug Sciences , University of Bari "Aldo Moro" , Bari , Italy.
authors: Mauro
authors: M
authors: Coluccia
authors: a Department of Pharmacy and CIRPeB , University of Naples "Federico II" , Naples , Italy .|b Istituto Di Biostrutture E Bioimmagini - CNR , Naples , Italy , and.
authors: Diego
authors: D
authors: Tesauro
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D065546:Drug Liberation; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D010316:Particle Size; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D008055:Lipids; D008081:Liposomes; D002945:Cisplatin
keywords: CDDP; cisplatin; drug delivery; gynecological tumors; liposomes