title: [The new paradigm of the developmental origin of health and diseases (DOHaD)--Epigenetics and environment: evidence and missing links].
abstract: According to the new paradigm of the Developpemental Origins of Health and Disease (DOHaD), the environmental factors to which an individual is exposed throughout his life can leave an epigenetic footprint on the genome. A crucial period is the early development, where the epigenome is particularly sensitive to the effects of the environment, and during which the individual builds up his health capital that will enable him to respond more or less well to the vagaries of life. The research challenge is to decipher the modes of action and the epigenetic mechanisms put into play by environmental factors that lead to increased disease susceptibility or resilience. The challenge for health is to translate these scientific discoveries into action through, among others, the establishment of preventive recommendations to slow down the growing incidence of non communicable diseases.
authors: Inra, UMR1198, biologie du développement et reproduction, Domaine de Vilvert, Bâtiment 230, F-78352 Jouy-en-Josas, France.
authors: Claudine
authors: C
authors: Junien
authors: Inra, UMR1198, biologie du développement et reproduction, Domaine de Vilvert, Bâtiment 230, F-78352 Jouy-en-Josas, France - Université Pierre et Marie Curie, F-75005 Paris, France.
authors: Polina
authors: P
authors: Panchenko
authors: Institut Carmen, Inserm U1060, Oullins, France.
authors: Luciano
authors: L
authors: Pirola
authors: UMR 1280 Inra université de Nantes, Institut des maladies de l'appareil digestif, Nantes, France.
authors: Valérie
authors: V
authors: Amarger
authors: UMR 1280 Inra université de Nantes, Institut des maladies de l'appareil digestif, Nantes, France.
authors: Bertrand
authors: B
authors: Kaeffer
authors: UMR 1280 Inra université de Nantes, Institut des maladies de l'appareil digestif, Nantes, France.
authors: Patricia
authors: P
authors: Parnet
authors: Inserm UMR1037, Centre de recherche en cancérologie de Toulouse, université de Toulouse III Paul Sabatier, F-31037 Toulouse, France.
authors: Jérôme
authors: J
authors: Torrisani
authors: UMR 1280 Inra université de Nantes, Institut des maladies de l'appareil digestif, Nantes, France.
authors: Francisco
authors: F
authors: Bolaños Jimenez
authors: Inra, UMR1198, biologie du développement et reproduction, Domaine de Vilvert, Bâtiment 230, F-78352 Jouy-en-Josas, France.
authors: Hélène
authors: H
authors: Jammes
authors: Inra, UMR1198, biologie du développement et reproduction, Domaine de Vilvert, Bâtiment 230, F-78352 Jouy-en-Josas, France.
authors: Anne
authors: A
authors: Gabory
mesh_terms: D004194:Disease / Q000209:etiology*; D004198:Disease Susceptibility / Q000209:etiology; D004777:Environment; D044127:Epigenesis, Genetic / Q000502:physiology*; D005260:Female; D059647:Gene-Environment Interaction; D006262:Health; D006801:Humans; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology* / Q000235:genetics