title: Catalytic Enantioselective Synthesis of Amino Skipped Diynes.
abstract: The Cu-catalyzed synthesis of nonracemic 3-amino skipped diynes via an enantiodetermining C-C bond formation is described using StackPhos as ligand. Despite challenging issues of reactivity and stereoselectivity inherent to these chiral skipped diynes, the reaction tolerates an extremely broad substrate scope with respect to all components and provides the title compounds in excellent enantiomeric excess. The alkyne moieties are demonstrated here to be useful synthetic handles, and 3-amino skipped diynes are convenient building blocks for enantioselective synthesis.
authors: Center for Heterocyclic Compounds, Department of Chemistry and ‡Center for X-ray Crystallography, Department of Chemistry, University of Florida , Gainesville, Florida 32611, United States.
authors: Paulo H S
authors: PH
authors: Paioti
authors: Center for Heterocyclic Compounds, Department of Chemistry and ‡Center for X-ray Crystallography, Department of Chemistry, University of Florida , Gainesville, Florida 32611, United States.
authors: Khalil A
authors: KA
authors: Abboud
authors: Center for Heterocyclic Compounds, Department of Chemistry and ‡Center for X-ray Crystallography, Department of Chemistry, University of Florida , Gainesville, Florida 32611, United States.
authors: Aaron
authors: A
authors: Aponick