title: Evaluation of the effect of oral omeprazole on canine cerebrospinal fluid production: A pilot study.
abstract: Administration of omeprazole by ventriculo-cisternal perfusion or intravenously has been shown to decrease cerebrospinal fluid (CSF) production in dogs and rabbits. Oral omeprazole has consequently been recommended to reduce CSF production in dogs with conditions in which clinical signs may be attributable to an accumulation of CSF in the central nervous system (e.g. hydrocephalus, syringomyelia). The albumin quotient (QAlb), the ratio between CSF and serum albumin concentration, has been proposed as a reliable means to evaluate CSF production; decreasing CSF production should cause an increase in QAlb. The aims of this study were to assess the effect of oral administration of omeprazole on QAlb in dogs and to compare two methods to assess CSF albumin concentration. Fifteen healthy Beagle dogs received omeprazole (1.2 mg/kg/day) orally for 14 days; CSF and blood were obtained before and after treatment. CSF albumin concentrations were evaluated by nephelometry and high-resolution protein electrophoresis. Regardless of the method used for measuring albumin, QAlb did not change significantly following oral omeprazole administration, suggesting that CSF production in healthy dogs may not be affected by chronic oral therapy with omeprazole.
authors: Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20, 4000 Liège, Belgium. Electronic address: maudgirod@msn.com.
authors: M
authors: M
authors: Girod
authors: Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20, 4000 Liège, Belgium.
authors: F
authors: F
authors: Allerton
authors: Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20, 4000 Liège, Belgium.
authors: K
authors: K
authors: Gommeren
authors: Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20, 4000 Liège, Belgium.
authors: A C
authors: AC
authors: Tutunaru
authors: Labocit, Citadelle Hospital, Boulevard du 12ème de Ligne 1, 4000 Liège, Belgium.
authors: J
authors: J
authors: de Marchin
authors: Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20, 4000 Liège, Belgium.
authors: I
authors: I
authors: Van Soens
authors: Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20, 4000 Liège, Belgium.
authors: E
authors: E
authors: Ramery
authors: Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20, 4000 Liège, Belgium.
authors: D
authors: D
authors: Peeters
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D002555:Cerebrospinal Fluid / Q000187:drug effects* / Q000378:metabolism; D004285:Dogs / Q000134:cerebrospinal fluid*; D004586:Electrophoresis / Q000662:veterinary*; D005260:Female; D008297:Male; D009391:Nephelometry and Turbidimetry / Q000662:veterinary*; D009853:Omeprazole / Q000009:adverse effects*; D010865:Pilot Projects; D054328:Proton Pump Inhibitors / Q000009:adverse effects; D012709:Serum Albumin / Q000032:analysis
chemical_list: D000897:Anti-Ulcer Agents; D015415:Biomarkers; D054328:Proton Pump Inhibitors; D012709:Serum Albumin; D009853:Omeprazole
keywords: Albumin quotient; Cerebrospinal fluid production; High-resolution electrophoresis; Nephelometry; Omeprazole