title: Generation of an artificial intestine for the management of short bowel syndrome.
abstract: OBJECTIVE
  This article discusses the current state of the art in artificial intestine generation in the treatment of short bowel syndrome.
  
  
  RESULTS
  Short bowel syndrome defines the condition in which patients lack sufficient intestinal length to allow for adequate absorption of nutrition and fluids, and thus need parenteral support. Advances toward the development of an artificial intestine have improved dramatically since the first attempts in the 1980s, and the last decade has seen significant advances in understanding the intestinal stem cell niche, the growth of complex primary intestinal stem cells in culture, and fabrication of the biomaterials that can support the growth and differentiation of these stem cells. There has also been recent progress in understanding the role of the microbiota and the immune cells on the growth of intestinal cultures on scaffolds in animal models. Despite recent progress, there is much work to be done before the development of a functional artificial intestine for short bowel syndrome is successfully achieved.
  
  
  CONCLUSIONS
  Continued concerted efforts by cell biologists, bioengineers, and clinician-scientists will be required for the development of an artificial intestine as a clinical treatment modality for short bowel syndrome.
authors: aDivisions of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, Maryland bDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, New York, USA.
authors: Mitchell R
authors: MR
authors: Ladd
authors: Diego F
authors: DF
authors: Niño
authors: John C
authors: JC
authors: March
authors: Chhinder P
authors: CP
authors: Sodhi
authors: David J
authors: DJ
authors: Hackam
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D006801:Humans; D007422:Intestines / Q000098:blood supply / Q000637:transplantation*; D012778:Short Bowel Syndrome / Q000601:surgery*; D023822:Tissue Engineering; D016896:Treatment Outcome