title: Th17 Cells in Type 1 Diabetes: Role in the Pathogenesis and Regulation by Gut Microbiome.
abstract: Type 1 diabetes (T1D) is an autoimmune disease which is characterized by progressive destruction of insulin producing pancreatic islet β cells. The risk of developing T1D is determined by both genetic and environmental factors. A growing body of evidence supports an important role of T helper type 17 (Th17) cells along with impaired T regulatory (Treg) cells in the development of T1D in animal models and humans. Alteration of gut microbiota has been implicated to be responsible for the imbalance between Th17 and Treg cells. However, there is controversy concerning a pathogenic versus protective role of Th17 cells in murine models of diabetes in the context of influence of gut microbiota. In this review we will summarize current knowledge about Th17 cells and gut microbiota involved in T1D and propose Th17 targeted therapy in children with islet autoimmunity to prevent progression to overt diabetes.
authors: Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.
authors: Yangyang
authors: Y
authors: Li
authors: Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.
authors: Yu
authors: Y
authors: Liu
authors: Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University and VA Portland Health Care System, Portland, OR 97239, USA.
authors: Cong-Qiu
authors: CQ
authors: Chu
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D000069196:Gastrointestinal Microbiome; D006801:Humans; D020381:Interleukin-17 / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D058504:Th17 Cells / Q000502:physiology*
chemical_list: D020381:Interleukin-17