title: Toward Carbon Monoxide-Based Therapeutics: Critical Drug Delivery and Developability Issues.
abstract: Carbon monoxide (CO) is an intrinsic signaling molecule with importance on par with that of nitric oxide. During the past decade, pharmacologic studies have amply demonstrated the therapeutic potential of carbon monoxide. However, such studies were mostly based on CO inhalation and metal-based CO-releasing molecules. The field is now at the stage that a major effort is needed to develop pharmaceutically acceptable forms of CO for delivery via various routes such as oral, injection, infusion, or topical applications. This review examines the state of the art, discusses the existing hurdles to overcome, and proposes developmental strategies necessary to address remaining drug delivery issues.
authors: Department of Chemistry and the Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, 30303.
authors: Xingyue
authors: X
authors: Ji
authors: Department of Chemistry and the Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, 30303.
authors: Krishna
authors: K
authors: Damera
authors: Department of Chemistry and the Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, 30303.
authors: Yueqin
authors: Y
authors: Zheng
authors: Department of Chemistry and the Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, 30303.
authors: Bingchen
authors: B
authors: Yu
authors: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215.
authors: Leo E
authors: LE
authors: Otterbein
authors: Department of Chemistry and the Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, 30303. Electronic address: wang@gsu.edu.
authors: Binghe
authors: B
authors: Wang
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002248:Carbon Monoxide / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D006801:Humans; D011355:Prodrugs / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D011355:Prodrugs; D002248:Carbon Monoxide
keywords: CO-RMs; carbon monoxide; enzyme activated; metal free; photosensitive; targeted delivery