title: Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress.
abstract: We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H2O2-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H2O2-treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.
authors: Division of Gastroenterology and Hepatology, Medical College of Georgia, Augusta, GA 30912, USA.
authors: Ravirajsinh N
authors: RN
authors: Jadeja
authors: Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors: Nathalie H
authors: NH
authors: Urrunaga
authors: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors: Daniel
authors: D
authors: Ahmad
authors: Division of Gastroenterology and Hepatology, Medical College of Georgia, Augusta, GA 30912, USA.
authors: Sandeep
authors: S
authors: Khurana
keywords: Catalase; Muscarinic receptors; Oxidative stress