title: Parental report of vaccine receipt in children with autism spectrum disorder: Do rates differ by pattern of ASD onset?
abstract: A contentious theory espoused by some parents is that regressive-onset of autism spectrum disorder (ASD) is triggered by vaccines. If this were true, then vaccine receipt should be higher in children with regressive-onset ASD compared with other patterns of onset. Parental report of rate of receipt for six vaccines (DPT/DTaP, HepB, Hib, polio, MMR, varicella) was examined in children with ASD (N=2755) who were categorized by pattern of ASD onset (early onset, plateau, delay-plus-regression, regression). All pairwise comparisons were significantly equivalent within a 10% margin for all vaccines except varicella, for which the delay-plus-regression group had lower rates of receipt (81%) than the early-onset (87%) and regression (87%) groups. Findings do not support a connection between regressive-onset ASD and vaccines in this cohort.
authors: Department of Pediatrics, Baylor College of Medicine, 8080 N. Stadium Drive, Suite 180, Houston, TX 77054, United States; Autism Center, Texas Children's Hospital, 8080 N. Stadium Drive, Suite 180, Houston, TX 77054, United States. Electronic address: kochel@bcm.edu.
authors: Robin P
authors: RP
authors: Goin-Kochel
authors: Department of Psychological, Health, and Learning Sciences, University of Houston, 491 Farish Hall, Houston, TX 77204, United States.
authors: Sarah S
authors: SS
authors: Mire
authors: Center for Clinical Research and Evidence-Based Medicine, Department of Pediatrics, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 2.106, Houston, TX 77030, United States.
authors: Allison G
authors: AG
authors: Dempsey
authors: Department of Psychological, Health, and Learning Sciences, University of Houston, 491 Farish Hall, Houston, TX 77204, United States.
authors: Rachel H
authors: RH
authors: Fein
authors: Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, One Baylor Plaza, Suite 100D, Houston, TX 77030, United States.
authors: Danielle
authors: D
authors: Guffey
authors: Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, One Baylor Plaza, Suite 100D, Houston, TX 77030, United States.
authors: Charles G
authors: CG
authors: Minard
authors: Immunization Project, Texas Children's Hospital, 1102 Bates Avenue, Suite 1550, Houston, TX 77030, United States.
authors: Rachel M
authors: RM
authors: Cunningham
authors: Immunization Project, Texas Children's Hospital, 1102 Bates Avenue, Suite 1550, Houston, TX 77030, United States.
authors: Leila C
authors: LC
authors: Sahni
authors: Department of Pediatrics, Baylor College of Medicine, 8080 N. Stadium Drive, Suite 180, Houston, TX 77054, United States; Immunization Project, Texas Children's Hospital, 1102 Bates Avenue, Suite 1550, Houston, TX 77030, United States.
authors: Julie A
authors: JA
authors: Boom
mesh_terms: D000293:Adolescent; D000067877:Autism Spectrum Disorder / Q000145:classification*; D002170:Canada; D019433:Chickenpox Vaccine / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006801:Humans; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage; D010290:Parents; D023321:Poliovirus Vaccines / Q000008:administration & dosage; D014481:United States; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: D019433:Chickenpox Vaccine; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D018073:Haemophilus Vaccines; D017325:Hepatitis B Vaccines; D022542:Measles-Mumps-Rubella Vaccine; D023321:Poliovirus Vaccines
keywords: ASD; Autism; Immunizations; Onset; Parent perception; Regression; Vaccines