title: Meta-analysis: The diagnostic efficacy of chromoendoscopy for early gastric cancer and premalignant gastric lesions.
abstract: OBJECTIVE
  Chromoendoscopy (CE) is widely used in the diagnosis of early gastric cancer (EGC) and premalignant gastric lesions (PGLs). We conducted a meta-analysis to evaluate the diagnostic efficacy of CE for EGC and PGLs.
  
  
  METHODS
  We searched PubMed/MEDLINE, EMBASE, and the Cochrane library to identify all eligible studies according to inclusion and exclusion standards. Publication bias was tested using Funnel plots and Egger's test. The possible sources of the heterogeneity were explored by performing a meta-regression analysis. Heterogeneity was assessed by the Q test and I(2) statistic.
  
  
  RESULTS
  Ten studies met the inclusion standards, including a total of 699 patients and 902 lesions. The pooled sensitivity, specificity, and area under the curve of CE were 0.90 (95% confidence interval, 0.87-0.92), 0.82 (95% confidence interval, 0.79-0.86), and 0.9464, respectively. In subgroup analysis of diagnostic accuracy, CE showed higher accuracy versus standard white light endoscopy for EGC (P = 0.005) and PGLs (P = 0.001).
  
  
  CONCLUSIONS
  Chromoendoscopy seems to have a high diagnostic efficacy and improve the detection of EGC and PGLs compared with standard white light endoscopy.
authors: Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors: Zhanwei
authors: Z
authors: Zhao
authors: Shaanxi Maternal and Child Health Hospital, Shaanxi Province, China.
authors: Zifang
authors: Z
authors: Yin
authors: Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors: Shiqi
authors: S
authors: Wang
authors: Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors: Juan
authors: J
authors: Wang
authors: Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors: Bing
authors: B
authors: Bai
authors: Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors: Zhaoyan
authors: Z
authors: Qiu
authors: Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Shaanxi Province, China. zhaoqc@fmmu.edu.cn.
authors: Qingchuan
authors: Q
authors: Zhao
mesh_terms: D004396:Coloring Agents; D055088:Early Detection of Cancer / Q000379:methods*; D005773:Gastroscopy / Q000379:methods*; D006801:Humans; D011230:Precancerous Conditions / Q000175:diagnosis*; D013274:Stomach Neoplasms / Q000175:diagnosis*
chemical_list: D004396:Coloring Agents
keywords: chromoendoscopy; early gastric cancer; premalignant gastric lesions; white light endoscopy