title: Separation of small organic molecules using covalent organic frameworks-LZU1 as stationary phase by open-tubular capillary electrochromatography.
abstract: Covalent organic frameworks (COFs) have attracted much attention because of their permanent nanoscale porosity and higher surface area compared to zeolites as well as robustness. COFs have great potential in several fields such as hydrogen storage, gas separation, and catalysis. However, COFs have not yet been applied in capillary electrochromatography. Herein, covalent organic frameworks-LZU1 (COF-LZU1) was used as the stationary phase in open-tubular capillary electrochromatography for the first time. Compared to the monoliths used in electrochromatography, the preparation technique of a COF-LZU1-coated capillary was simple and practical. The baseline separation of model analytes including alkylbenzenes, polyaromatic hydrocarbons, and anilines by the COF-LZU1-coated capillary was achieved based on the size selectivity of COF-LZU1 porous structure and hydrophobic interactions between the model analytes and organic ligands of COF-LZU1. The load capacity of the COF-LZU1-coated capillary for naphthalene was 0.6mg/mL. For three consecutive runs, the intraday relative standard deviations (RSDs) were 1.4-2.6% for the migration time and 2.7-8.7% for the peak area. The interday RSDs were 1.3-3.9% for the migration time and 3.7-9.7% for the peak area. The column-to-column reproducibility of migration time was in the range 1.0-3.9%. Moreover, the coated capillary was used for >300 runs with no changes in the separation efficiency. Thus, COFs have great potential in capillary electrochromatography and may provide a new method for chromatographic separation.
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu 730000, China.
authors: Xiaoying
authors: X
authors: Niu
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
authors: Sanyuan
authors: S
authors: Ding
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu 730000, China.
authors: Weifeng
authors: W
authors: Wang
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu 730000, China.
authors: Yali
authors: Y
authors: Xu
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu 730000, China.
authors: Yinyin
authors: Y
authors: Xu
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu 730000, China.
authors: Hongli
authors: H
authors: Chen
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu 730000, China; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China. Electronic address: chenxg@lzu.edu.cn.
authors: Xingguo
authors: X
authors: Chen
mesh_terms: D001555:Benzene Derivatives / Q000032:analysis / Q000737:chemistry*; D053801:Capillary Electrochromatography / Q000379:methods; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis; D016062:Porosity; D015203:Reproducibility of Results
chemical_list: D001555:Benzene Derivatives; D011084:Polycyclic Aromatic Hydrocarbons
keywords: COF-LZU1; Open-tubular capillary electrochromatography; Small organic molecules