title: Molecular Aberrance in Papillary Thyroid Microcarcinoma Bearing High Aggressiveness: Identifying a "Tibetan Mastiff Dog" From Puppies.
abstract: Today the most common differentiated thyroid cancer in many countries is papillary thyroid microcarcinoma (PTMC). Although the majority of PTMCs exhibit an indolent clinical course, a few possess high risk for aggressiveness with tumor invasion, metastasis, and even patient mortality. This imposes significant confusion and often dilemma in the clinical management of PTMC. The present review summarizes the molecular pathogenesis, particularly the major genetic alterations, of PTMC that may have prognostic values in assisting risk stratification of this cancer and identification of the most aggressive cases from the many well-behaving cases. J. Cell. Biochem. 117: 1491-1496, 2016. © 2016 Wiley Periodicals, Inc.
authors: Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
authors: Dapeng
authors: D
authors: Li
authors: Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
authors: Ming
authors: M
authors: Gao
authors: Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, 77025.
authors: Xiaolong
authors: X
authors: Li
authors: Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287.
authors: Mingzhao
authors: M
authors: Xing
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000453:epidemiology / Q000235:genetics / Q000401:mortality / Q000628:therapy; D002291:Carcinoma, Papillary; D018572:Disease-Free Survival; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D015996:Survival Rate; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000401:mortality / Q000628:therapy
keywords: BRAFV600E; MUTATION; PAPILLARY THYROID MICROCARCINOMA; TERT; miRNA