title: The Suicidal Risks and Treatments, Seek Medications from Multi-disciplinary.
abstract: Suicide events and episodes are serious human psychiatric disorders affected by a great number of different environmental/economic factors, early trauma/abuse, human bad living habits, human genomic properties and drug intervention decisions. In order to improve antidepressant therapeutics in clinics, the relationships between efficacy and toxicities of antidepressants have to be considered fundamentally. Since the occurrences and risks of suicidal events or episodes come from interplay between insiders (chemical/genomic/bioinformatics factors) and outsiders (economic/social/ previous trauma conditions and so on), new perspectives and scientific studies must be implemented for revealing these interrelated factors step-by-step and updating therapeutics in human beings. New paradigms and clinical strategies -joint-expert groups and clinical practices (a psychiatrist with other field specialists) should be established for individual patients in future. Thus can some improvements in clinical trials be achieved in a long run?
authors: Shanghai University, Shanghai 200444, PR China.
authors: Da-Yong
authors: DY
authors: Lu
authors: Peng-Peng
authors: PP
authors: Zhu
authors: Ting-Ren
authors: TR
authors: Lu
authors: Jin-Yu
authors: JY
authors: Che
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000379:methods; D003131:Combined Modality Therapy / Q000379:methods; D003863:Depression / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*; D006801:Humans; D012307:Risk Factors; D059020:Suicidal Ideation; D013405:Suicide / Q000523:psychology; D016896:Treatment Outcome; D000092864:Suicide Prevention
chemical_list: D000928:Antidepressive Agents