title: Antiproliferative Activity of Some Higher Mushrooms from Hungary against Human Cancer Cell Lines.
abstract: In the present work, aqueous and organic extracts of 16 Basidiomycetes mushrooms and 1 Ascomycetes mushroom were investigated in vitro for their antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma), and MCF7 (breast epithelial adenocarcinoma) cells, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A total of 68 n-hexane, chloroform, 50% methanol, and water extracts of selected species were screened for their potential cell growth inhibitory activity. Our experiments revealed that 7 of 17 species demonstrated notable antiproliferative activity (at least 50% inhibition of cell proliferation) against one or more cell lines. Kuehneromyces mutabilis, Lactarius quietus, and Lentinellus cochleatus, which exerted the highest activity on cancer cells, are considered valuable species in the perspective of further mycochemical studies.
authors: Department of Pharmacognosy, University of Szeged, Szeged, Hungary.
authors: Attila
authors: A
authors: Vanyolos
authors: Department of Pharmacognosy, University of Szeged, Szeged, Hungary.
authors: Bernadett
authors: B
authors: Kovacs
authors: Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
authors: Noemi
authors: N
authors: Bozsity
authors: Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
authors: Istvan
authors: I
authors: Zupko
authors: Department of Pharmacognosy, University of Szeged, Szeged, Hungary.
authors: Judit
authors: J
authors: Hohmann
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D006814:Hungary