title: Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients.
abstract: Radiation pneumonitis (RP) is one of the most important dose-limiting toxicities in the radiotherapy of thoracic tumors, which reduces the rate of local tumor control and overall survival and severely affects the patients' quality of life. Single-nucleotide polymorphisms (SNPs) have recently attracted increasing attention as biomarkers for predicting the development of RP. SNPs in inflammation-related, DNA repair-related, stress response-related and angiogenesis-related genes were proved to be associated with RP, with different underlying mechanisms. Radiogenomics focuses on the differences in radiosensitivity caused by gene sequence variation, which may prove helpful in investigating the abovementioned associations. In this review, we aimed to investigate the associations between RP and SNPs reported in recent studies and highlight the main content and prospects of radiogenomics.
authors: Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.
authors: Cheng-Xian
authors: CX
authors: Guo
authors: Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China; Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China.
authors: Jing
authors: J
authors: Wang
authors: Center for Experimental Medical Research, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.
authors: Li-Hua
authors: LH
authors: Huang
authors: Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China.
authors: Jin-Gao
authors: JG
authors: Li
authors: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China.
authors: Xiang
authors: X
authors: Chen
keywords: genetic markers; radiation pneumonitis; single-nucleotide polymorphisms