title: Relation of Plasma Fibrinogen Level With the Presence, Severity, and Complexity of Coronary Artery Disease.
abstract: BACKGROUND
  Relation of plasma fibrinogen levels with extent, severity, and complexity of coronary artery disease (CAD) in patients with stable angina pectoris (SAP) has not been adequately investigated. The aim of this study was to evaluate whether plasma fibrinogen level is associated with coronary complexity, severity, and extent assessed by SYNTAX (Synergy between percutaneous coronary intervention with TAXUS and Cardiac Surgery) score (SS).
  
  
  METHODS
  We enrolled 134 consecutive patients with SAP who underwent coronary angiography. Baseline serum fibrinogen levels were measured, and SS was calculated from the study population. The patients were classified into 3 groups by tertiles of SS (SS, control group = 0; intermediate group < 22; and high group ≥ 22).
  
  
  RESULTS
  Plasma fibrinogen levels demonstrated a stepwise increase from control group to high SS group. There was a strong correlation between fibrinogen and the SS ( r = .535, P < .001). Area under the receivers operating characteristic curve of fibrinogen was 0.72 (95% confidence interval [CI] 0.61-0.82; < .001) for predicting a high SS. Fibrinogen value higher than 411 mg/dL has a sensitivity of 75% and a specificity of 64% in prediction of high SS. In multivariate analyses, plasma fibrinogen was observed to be an independent predictor for high SS in patients with stable CAD (odds ratio [OR] 1.01; 95% CI, 1.01-1.02; P < .001).
  
  
  CONCLUSIONS
  Plasma fibrinogen is a readily measurable systemic inflammatory marker and is independently associated coronary severity and complexity in patients with CAD.
authors: 1 Cardiology Department, Kartal Koşuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey.
authors: Mehmet Mustafa
authors: MM
authors: Tabakcı
authors: 2 Public Health Core Laboratory, Istanbul, Turkey.
authors: Fethullah
authors: F
authors: Gerin
authors: 3 Department of Cardiology, Medical Faculty, Marmara University, Istanbul, Turkey.
authors: Murat
authors: M
authors: Sunbul
authors: 1 Cardiology Department, Kartal Koşuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey.
authors: Cuneyt
authors: C
authors: Toprak
authors: 4 Tavşanlı State Hospital, Kutahya, Turkey.
authors: Halil İbrahim
authors: Hİ
authors: Durmuş
authors: 1 Cardiology Department, Kartal Koşuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey.
authors: Serdar
authors: S
authors: Demir
authors: 1 Cardiology Department, Kartal Koşuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey.
authors: Uğur
authors: U
authors: Arslantaş
authors: 1 Cardiology Department, Kartal Koşuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey.
authors: Sinan
authors: S
authors: Cerşit
authors: 1 Cardiology Department, Kartal Koşuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey.
authors: Ulaankhuu
authors: U
authors: Batgerel
authors: 1 Cardiology Department, Kartal Koşuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey.
authors: Ramazan
authors: R
authors: Kargın
mesh_terms: D000368:Aged; D060050:Angina, Stable; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D005340:Fibrinogen
keywords: angina pectoris; coronary; fibrinogen; syntax score