title: Frequency of varicella zoster virus DNA in human adrenal glands.
abstract: Varicella zoster virus (VZV) becomes latent in ganglionic neurons derived from neural crest cells. Because the adrenal gland also contains medullary chromaffin cells of neural crest origin, we examined human adrenal glands and medullary chromaffin cell tumors (pheochromocytomas) for VZV and herpes simplex virus type 1 (HSV-1). We found VZV, but not HSV-1, DNA in 4/63 (6 %) normal adrenal glands. No VZV transcripts or antigens were detected in the 4 VZV DNA-positive samples. No VZV or HSV-1 DNA was found in 21 pheochromocytomas.
authors: Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.
authors: Hussain
authors: H
authors: Badani
authors: Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.
authors: Teresa
authors: T
authors: White
authors: Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.
authors: Nicole
authors: N
authors: Schulick
authors: Department of Surgery, University of Colorado School of Medicine, 12631 E. 17th Avenue, Box C-305, Aurora, CO, 80045, USA.
authors: Christopher D
authors: CD
authors: Raeburn
authors: Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.
authors: Ibrahim
authors: I
authors: Topkaya
authors: Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.|Department of Immunology and Microbiology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA.
authors: Don
authors: D
authors: Gilden
authors: Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B-182, Aurora, CO, 80045, USA. maria.nagel@ucdenver.edu.
authors: Maria A
authors: MA
authors: Nagel
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000737:chemistry / Q000473:pathology; D000311:Adrenal Glands / Q000166:cytology / Q000821:virology*; D000369:Aged, 80 and over; D058070:Asymptomatic Diseases; D004279:DNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D006561:Herpes Simplex; D018259:Herpesvirus 1, Human; D014645:Herpesvirus 3, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000737:chemistry / Q000473:pathology; D016133:Polymerase Chain Reaction; D000073618:Varicella Zoster Virus Infection / Q000821:virology; D017735:Virus Latency
chemical_list: D004279:DNA, Viral
keywords: Adrenal gland; Latency; Pheochromocytoma; VZV