title: ALDH2 polymorphism for the risk of cervical carcinogenesis.
abstract: To investigate the clinical significance of ALDH2 genetic polymorphisms in cervical carcinogenesis. ALDH2 polymorphisms together with human papillomavirus (HPV) types were examined in a total of 195 cervical smear in exfoliated cervical cell samples using Real-Time polymerase chain reaction (PCR) System. The frequency for the AG+AA genotype was seven in the normal group (70.0 %), 16 in the LSIL group (57.1 %), and 27 in the HSIL group (90.0 %). A significant difference was found between the LSIL and HSIL groups (P = 0.0064). Patients with HSIL lesions frequently had high-risk HPV infections and concurrently belonged to the AG+AA group. ALDH2 genotype in cervical cell samples may be associated with more severe precancerous lesions of the cervix in a Japanese population.
authors: Department of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagata-ku, Kobe, Hyogo, 6530838, Japan. o-nunobiki@kobe-tokiwa.ac.jp.
authors: Osamu
authors: O
authors: Nunobiki
authors: Department of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagata-ku, Kobe, Hyogo, 6530838, Japan.
authors: Daisuke
authors: D
authors: Sano
authors: Department of Obstetrics and Gynecology, Kyoto Prefectural University, Kyoto, Japan.
authors: Kyoko
authors: K
authors: Akashi
authors: Department of Obstetrics and Gynecology, Akou City Hospital, Akou, Hyogo, Japan.
authors: Taro
authors: T
authors: Higashida
authors: Department of Obstetrics and Gynecology, Okubo Hospital, Okubo, Hyogo, Japan.
authors: Toshitada
authors: T
authors: Ogasawara
authors: Cytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
authors: Hikari
authors: H
authors: Akise
authors: Cytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
authors: Shinji
authors: S
authors: Izuma
authors: Cytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
authors: Kiyo
authors: K
authors: Torii
authors: Cytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
authors: Yoshiaki
authors: Y
authors: Okamoto
authors: Cytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
authors: Ichiro
authors: I
authors: Tanaka
authors: Cytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
authors: Masatsugu
authors: M
authors: Ueda
mesh_terms: D000071396:Aldehyde Dehydrogenase, Mitochondrial / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D027383:Papillomaviridae / Q000145:classification; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000821:virology
chemical_list: C096127:ALDH2 protein, human; D000071396:Aldehyde Dehydrogenase, Mitochondrial
keywords: ALDH2; Cervical carcinogenesis; Polymorphism; SIL