title: Data on bone marrow stem cells delivery using porous polymer scaffold.
abstract: Low bioavailability and/or survival at the injury site of transplanted stem cells necessitate its delivery using a biocompatible, biodegradable cell delivery vehicle. In this dataset, we report the application of a porous biocompatible, biodegradable polymer network that successfully delivers bone marrow stem cells (BMSCs) at the wound site of a murine excisional splint wound model. In this data article, we are providing the additional data of the reference article "Porous polymer scaffold for on-site delivery of stem cells - protects from oxidative stress and potentiates wound tissue repair" (Ramasatyaveni et al., 2016) [1]. This data consists of the characterization of bone marrow stem cells (BMSCs) showing the pluripotency and stem cell-specific surface markers. Image analysis of the cellular penetration into PEG-PU polymer network and the mechanism via enzymatic activation of MMP-2 and MMP-13 are reported. In addition, we provide a comparison of various routes of transplantation-mediated BMSCs engraftment in the murine model using bone marrow transplantation chimeras. Furthermore, we included in this dataset the engraftment of BMSCs expressing Sca-1(+)Lin(-)CD133(+)CD90.2(+) in post-surgery day 10.
authors: Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India; Academy of Scientific & Innovative Research (AcSIR), 2 Rafi Marg, New Delhi 110001, India.
authors: Ramasatyaveni
authors: R
authors: Geesala
authors: Nanomaterials Laboratory, Division of Inorganic and Physical Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India; Academy of Scientific & Innovative Research (AcSIR), 2 Rafi Marg, New Delhi 110001, India.
authors: Nimai
authors: N
authors: Bar
authors: Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India; Academy of Scientific & Innovative Research (AcSIR), 2 Rafi Marg, New Delhi 110001, India.
authors: Neha R
authors: NR
authors: Dhoke
authors: Nanomaterials Laboratory, Division of Inorganic and Physical Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India; Academy of Scientific & Innovative Research (AcSIR), 2 Rafi Marg, New Delhi 110001, India.
authors: Pratyay
authors: P
authors: Basak
authors: Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India; Academy of Scientific & Innovative Research (AcSIR), 2 Rafi Marg, New Delhi 110001, India.
authors: Amitava
authors: A
authors: Das