title: Recognizing the Limited Applicability of Job Plots in Studying Host-Guest Interactions in Supramolecular Chemistry.
abstract: Continuous variation method, known as Job plot, is the most commonly applied method for the determination of stoichiometry of complex chemical entities for over 100 years. Although, the method was proven successful in the analysis of very stable metal-ligand complexes, we demonstrate that its use in supramolecular chemistry often provides false results. We support this statement with multiple simulations as well as cases studies of several real host-guest systems. We propose an alternative, general method relying on the analysis of residual distribution in titration data fitting. The latter method is more convenient compared to the Job plot and unlike it gives correct results in all real cases studied.
authors: Institute of Organic Chemistry, Polish Academy of Sciences , Kasprzaka 44/50 01-224 Warsaw, Poland.
authors: Filip
authors: F
authors: Ulatowski
authors: Institute of Organic Chemistry, Polish Academy of Sciences , Kasprzaka 44/50 01-224 Warsaw, Poland.
authors: Kajetan
authors: K
authors: Dąbrowa
authors: Institute of Organic Chemistry, Polish Academy of Sciences , Kasprzaka 44/50 01-224 Warsaw, Poland.
authors: Tomasz
authors: T
authors: Bałakier
authors: Institute of Organic Chemistry, Polish Academy of Sciences , Kasprzaka 44/50 01-224 Warsaw, Poland.
authors: Janusz
authors: J
authors: Jurczak