title: New insulins and newer insulin regimens: a review of their role in improving glycaemic control in patients with diabetes.
abstract: The legacy effect of early good glycaemic control in people with diabetes shows it is associated with reduction of microvascular and macrovascular complications. Insulin therapy is essential and lifesaving in individuals with type 1 diabetes and beneficial for those with type 2 diabetes who fail to achieve optimal glycaemic targets with other classes of glucose-lowering therapies. Since the introduction of insulin analogues, insulin management has changed. This follow-up review attempts to update our earlier publication from 2009 and discusses the role of new insulin analogues and newer insulin regimens. Recognising the advent of new quality and economic initiatives both in the UK and worldwide, this paper reviews current insulin prescribing and the pros and cons of prescribing analogues in comparison to the human insulins that are now gaining more acceptance in everyday clinical practice.
authors: Department of Diabetes & Endocrinology, University Hospitals of Leicester NHS Trust, Leicester, UK.
authors: S
authors: S
authors: Gururaj Setty
authors: Department of Diabetes & Endocrinology, George Eliot NHS Trust, Nuneaton, UK.
authors: W
authors: W
authors: Crasto
authors: Diabetes Research Centre, University of Leicester, Leicester, UK.
authors: J
authors: J
authors: Jarvis
authors: Diabetes Research Centre, University of Leicester, Leicester, UK.
authors: K
authors: K
authors: Khunti
authors: Department of Diabetes & Endocrinology, University Hospitals of Leicester NHS Trust, Leicester, UK Diabetes Research Centre, University of Leicester, Leicester, UK.
authors: M J
authors: MJ
authors: Davies
mesh_terms: D001786:Blood Glucose / Q000187:drug effects*; D032921:Consensus; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D019317:Evidence-Based Medicine; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000187:drug effects*; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007328:Insulin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D017410:Practice Guidelines as Topic
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; C517652:hemoglobin A1c protein, human
keywords: DIABETES & ENDOCRINOLOGY