title: Enantioselective Hydrogenation of β,β-Disubstituted Unsaturated Carboxylic Acids under Base-Free Conditions.
abstract: An additive-free enantioselective hydrogenation of β,β-disubstituted unsaturated carboxylic acids catalyzed by the Rh-(R,R)-f-spiroPhos complex has been developed. Under mild conditions, a wide scope of β,β-disubstituted unsaturated carboxylic acids were hydrogenated to the corresponding chiral carboxylic acids with excellent enantioselectivities (up to 99.3% ee). This methodology was also successfully applied to the synthesis of the pharmaceutical molecule indatraline.
authors: Key Laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors: Qiaozhi
authors: Q
authors: Yan
authors: Key Laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors: Duanyang
authors: D
authors: Kong
authors: Key Laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors: Wei
authors: W
authors: Zhao
authors: Key Laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors: Guofu
authors: G
authors: Zi
authors: Key Laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors: Guohua
authors: G
authors: Hou