title: Choroidal Neovascularization Analyzed on Ultrahigh-Speed Swept-Source Optical Coherence Tomography Angiography Compared to Spectral-Domain Optical Coherence Tomography Angiography.
abstract: OBJECTIVE
  To compare visualization of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using an ultrahigh-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype vs a spectral-domain (SD) OCTA device.
  
  
  METHODS
  Comparative analysis of diagnostic instruments.
  
  
  METHODS
  Patients were prospectively recruited to be imaged on SD OCT and SS OCT devices on the same day. The SD OCT device employed is the RTVue Avanti (Optovue, Inc, Fremont, California, USA), which operates at ∼840 nm wavelength and 70 000 A-scans/second. The SS OCT device used is an ultrahigh-speed long-wavelength prototype that operates at ∼1050 nm wavelength and 400 000 A-scans/second. Two observers independently measured the CNV area on OCTA en face images from the 2 devices. The nonparametric Wilcoxon signed rank test was used to compare area measurements and P values of <.05 were considered statistically significant.
  
  
  RESULTS
  Fourteen eyes from 13 patients were enrolled. The CNV in 11 eyes (78.6%) were classified as type 1, 2 eyes (14.3%) as type 2, and 1 eye (7.1%) as mixed type. Total CNV area measured using SS OCT and SD OCT 3 mm × 3 mm OCTA were 0.949 ± 1.168 mm(2) and 0.340 ± 0.301 mm(2), respectively (P = .001). For the 6 mm × 6 mm OCTA the total CNV area using SS OCT and SD OCT were 1.218 ± 1.284 mm(2) and 0.604 ± 0.597 mm(2), respectively (P = .0019). The field of view did not significantly affect the measured CNV area (P = .19 and P = .18 for SS OCT and SD OCT, respectively).
  
  
  CONCLUSIONS
  SS OCTA yielded significantly larger CNV areas than SD OCTA. It is possible that SS OCTA is better able to demarcate the full extent of CNV vasculature.
authors: New England Eye Center, Tufts Medical Center, Boston, Massachusetts; Federal University of São Paulo, School of Medicine, São Paulo, Brazil.
authors: Eduardo A
authors: EA
authors: Novais
authors: New England Eye Center, Tufts Medical Center, Boston, Massachusetts; Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors: Mehreen
authors: M
authors: Adhi
authors: Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors: Eric M
authors: EM
authors: Moult
authors: New England Eye Center, Tufts Medical Center, Boston, Massachusetts; Federal University of Goiás, Goiânia, Brazil.
authors: Ricardo N
authors: RN
authors: Louzada
authors: New England Eye Center, Tufts Medical Center, Boston, Massachusetts; Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors: Emily D
authors: ED
authors: Cole
authors: Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts; Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
authors: Lennart
authors: L
authors: Husvogt
authors: Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors: ByungKun
authors: B
authors: Lee
authors: New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
authors: Sabin
authors: S
authors: Dang
authors: New England Eye Center, Tufts Medical Center, Boston, Massachusetts; Federal University of São Paulo, School of Medicine, São Paulo, Brazil.
authors: Caio V S
authors: CV
authors: Regatieri
authors: New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
authors: André J
authors: AJ
authors: Witkin
authors: New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
authors: Caroline R
authors: CR
authors: Baumal
authors: Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany; Erlangen Graduate School in Advanced Optical Technologies (SAOT), Erlangen, Germany.
authors: Joachim
authors: J
authors: Hornegger
authors: Praevium Research Inc, Santa Barbara, California.
authors: Vijaysekhar
authors: V
authors: Jayaraman
authors: Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors: James G
authors: JG
authors: Fujimoto
authors: New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
authors: Jay S
authors: JS
authors: Duker
authors: New England Eye Center, Tufts Medical Center, Boston, Massachusetts. Electronic address: nadiakwaheed@gmail.com.
authors: Nadia K
authors: NK
authors: Waheed
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D002829:Choroid / Q000098:blood supply; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012171:Retinal Vessels / Q000473:pathology; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D057135:Wet Macular Degeneration / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A