title: TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis.
abstract: The matrix-specific protein periostin (POSTN) is up-regulated in human cancers and associated with cancer growth, metastasis and angiogenesis. Although the stroma of cancer tissues is the main source of POSTN, it is still unclear how POSTN plays a role to facilitate the interplay between cancer cells and cancer-associated fibroblasts (CAFs) in head and neck cancer (HNC), thereby promoting tumorigenesis via modifying the tumor microenvironment. Herein, we have performed studies to investigate POSTN and its role in HNC microenvironment. Our results indicated that POSTN was significantly up-regulated in HNCs, especially in the tissues with lymph node metastasis. Moreover, POSTN was highly enriched in the stroma of cancer tissues and produced mainly by CAFs. More importantly, we have pinpointed TGF-β3 as the major upstream molecular that triggers the induction of POSTN in CAFs. As such, during the interaction between fibroblasts and cancer cells, the increased stromal POSTN induced by TGF-β3 directly accelerated the growth, migration and invasion of cancer cells. Hence, our study has provided a novel modulative role for POSTN on HNC progression and further reveals POSTN as an effective biomarker to predict metastasis as well as a potential cancer therapeutic target.
authors: Department of Oral and Maxillofacial-Head &Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.|Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
authors: Xing
authors: X
authors: Qin
authors: Department of Oral and Maxillofacial-Head &Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.|Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
authors: Ming
authors: M
authors: Yan
authors: Department of Oral and Maxillofacial-Head &Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.|Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
authors: Jianjun
authors: J
authors: Zhang
authors: Department of Oral and Maxillofacial-Head &Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.|Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
authors: Xu
authors: X
authors: Wang
authors: Department of Oral and Maxillofacial-Head &Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.|Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
authors: Zongze
authors: Z
authors: Shen
authors: Department of Oral and Maxillofacial-Head &Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.|Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
authors: Zhongjing
authors: Z
authors: Lv
authors: Department of Oral and Maxillofacial-Head &Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.|Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
authors: Zhihui
authors: Z
authors: Li
authors: Department of Oral and Maxillofacial-Head &Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.|Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
authors: Wenyi
authors: W
authors: Wei
authors: Department of Oral and Maxillofacial-Head &Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.|Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
authors: Wantao
authors: W
authors: Chen
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D053782:Transforming Growth Factor beta3 / Q000494:pharmacology*; D059016:Tumor Microenvironment / Q000187:drug effects*
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D009363:Neoplasm Proteins; C512835:POSTN protein, human; C509044:TGFB3 protein, human; D053782:Transforming Growth Factor beta3