title: Sorafenib and gadolinium co-loaded liposomes for drug delivery and MRI-guided HCC treatment.
abstract: To improve the poor water solubility of sorafenib and to monitor its distribution and the early feedback effects on its in vivo treatment efficacy in a precise manner, sorafenib (SF) and gadolinium (Gd) co-loaded liposomes (SF/Gd-liposomes) were prepared. The simultaneous imaging and therapy efficacies of the SF/Gd-liposomes were tested. The solubility of SF in SF/Gd-liposomes was significantly increased from 0.21 μg/mL to 250 μg/mL. The imaging capability of SF/Gd-liposomes were tested by in-vitro and the in-vivo imaging ability tests and the results confirmed that SF/Gd-liposomes could be served as an effective contrast agent. The design of SF/Gd-liposomes allowed the MRI-guided in vivo visualization of the delivery and biodistribution of liposome. In the in vivo antitumor studies, SF/Gd-liposomes had better antitumor effects in H22 tumor-bearing mice than SF solution (oral or i.v. administration) (P<0.05). These findings indicated that the SF/Gd-liposomes could be used as the promising nano-carriers for the MRI-guided in vivo visualization of the delivery and HCC treatment.
authors: School of Pharmaceutical Science, Shandong University, Jinan, People's Republic of China.
authors: Yanan
authors: Y
authors: Xiao
authors: School of Pharmaceutical Science, Shandong University, Jinan, People's Republic of China.
authors: Yongjun
authors: Y
authors: Liu
authors: School of Pharmaceutical Science, Shandong University, Jinan, People's Republic of China.
authors: Shaomei
authors: S
authors: Yang
authors: School of Pharmaceutical Science, Shandong University, Jinan, People's Republic of China.
authors: Bo
authors: B
authors: Zhang
authors: School of Pharmaceutical Science, Shandong University, Jinan, People's Republic of China.
authors: Tianqi
authors: T
authors: Wang
authors: School of Pharmaceutical Science, Shandong University, Jinan, People's Republic of China.
authors: Dandan
authors: D
authors: Jiang
authors: School of Pharmaceutical Science, Shandong University, Jinan, People's Republic of China.
authors: Jing
authors: J
authors: Zhang
authors: Department of Radiology Medicine, Affiliated Qilu Hospital, Shandong University, Jinan, People's Republic of China. Electronic address: ydx0330@sina.com.
authors: Dexin
authors: D
authors: Yu
authors: School of Pharmaceutical Science, Shandong University, Jinan, People's Republic of China. Electronic address: zhangnancy9@sdu.edu.cn.
authors: Na
authors: N
authors: Zhang
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D046529:Microscopy, Electron, Transmission; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry; D010671:Phenylurea Compounds / Q000008:administration & dosage / Q000737:chemistry; D000077157:Sorafenib; D014018:Tissue Distribution; D016896:Treatment Outcome; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D003287:Contrast Media; D008081:Liposomes; D010671:Phenylurea Compounds; D009536:Niacinamide; D000077157:Sorafenib; D005682:Gadolinium
keywords: Hepatocellular carcinoma; MRI-guided; Sorafenib and gadolinium co-loaded liposomes