title: Serum paraoxonase level and paraoxonase polymorphism in patients with acromegaly.
abstract: BACKGROUND
  Acromegalic patients have increased cardiometabolic risk factors due to an elevation of growth hormone (GH) levels. Human serum paraoxonase (PON), a high-density lipoprotein (HDL)-related enzyme, is one of the major bioscavengers and decreases the oxidation of low-density lipoprotein (LDL), a key regulator in the pathogenesis of atherosclerosis. In this study, we investigated a potential relationship between serum PON levels or PON polymorphisms and acromegaly.
  
  
  METHODS
  A total of 48 acromegalic patients and 44 healthy controls were included in this study. Serum GH levels, insulin-like growth factor-1 levels and lipid profiles were measured. Serum PON levels, as well as PON 1 L55M and Q192R gene polymorphisms, were examined.
  
  
  RESULTS
  No significant differences were found in terms of age, gender, presence of diabetes, serum LDL cholesterol (LDL-C), HDL-C, or triglyceride levels between the case and control groups (P > 0.05). A statistically significant difference was found in serum PON levels between the cases and controls (P = 0.007). The median serum PON level was 101 ± 63.36 U/l in the case group and 63 ± 60.50 U/l in the control group. There was a significant correlation between serum PON levels and IGF-1 levels (P = 0.004, r = 0.319); however, no significant differences were found in PON1 L55M and PON Q192R polymorphisms between the patients and controls (P = 0.607 and P = 0.308, respectively). In addition, no significant differences were found in serum PON levels in acromegalic patients who were and were not in remission (P = 0.385), nor between those with PON1 L55M and Q192R polymorphisms (P = 0.161 and P = 0.336, respectively).
  
  
  CONCLUSIONS
  Elevated serum PON levels were detected in acromegalic patients, independently of their remission status. This suggests protective effects for cardiometabolic risk parameters.
authors: a Faculty of Medicine, Department of Endocrinology and Metabolism , Bulent Ecevit University , Zonguldak , Turkey.
authors: Dilek
authors: D
authors: Arpaci
authors: b Graduate School of Natural and Applied Sciences, Department of Biology , Bulent Ecevit University , Zonguldak , Turkey.
authors: Sevim
authors: S
authors: Karakas Celik
authors: c Faculty of Medicine, Department of Biochemistry , Bulent Ecevit University , Zonguldak , Turkey.
authors: Murat
authors: M
authors: Can
authors: d Faculty of Arts and Sciences, Department of Molecular Biology and Genetics , Bulent Ecevit University , Zonguldak , Turkey.
authors: Esra
authors: E
authors: Ermiş
authors: a Faculty of Medicine, Department of Endocrinology and Metabolism , Bulent Ecevit University , Zonguldak , Turkey.
authors: Fatih
authors: F
authors: Kuzu
authors: e Faculty of Medicine, Department of Biostatistics , Bulent Ecevit University , Zonguldak , Turkey.
authors: Furuzan
authors: F
authors: Kokturk
authors: f Faculty of Chemisty , Bulent Ecevit University , Zonguldak , Turkey.
authors: Ayse Ceylan
authors: AC
authors: Hamamcioglu
authors: d Faculty of Arts and Sciences, Department of Molecular Biology and Genetics , Bulent Ecevit University , Zonguldak , Turkey.
authors: Ahmet
authors: A
authors: Dursun
authors: a Faculty of Medicine, Department of Endocrinology and Metabolism , Bulent Ecevit University , Zonguldak , Turkey.
authors: Taner
authors: T
authors: Bayraktaroglu
mesh_terms: D000172:Acromegaly; D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000235:genetics*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D055815:Young Adult
chemical_list: D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D007334:Insulin-Like Growth Factor I; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Acromegaly; Paraoxonase; Polymorphism