title: Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis.
abstract: Basal core promoter (BCP) A1762T/G1764A dual mutations in hepatocarcinogenesis remain controversial. Published studies up to June 1, 2015 investigating the frequency of A1762T/G1764A dual mutations from chronic hepatitis B virus (HBV) infection, including hepatocellular carcinoma (HCC), were systematically identified. A total of 10,240 patients with chronic HBV infection, including 3729 HCC cases, were included in 52 identified studies. HCC patients had a higher frequency of BCP A1762T/G1764A dual mutations compared with asymptomatic HBsAg carriers (ASC) and patients with chronic hepatitis B (CHB) and liver cirrhosis (LC) (OR = 5.59, P < 0.00001; OR = 2.87, P < 0.00001; OR = 1.55, P = 0.02, respectively). No statistically significant difference was observed in the frequency of A1762T/G1764A dual mutations in cirrhotic HCC versus non-cirrhotic HCC patients (OR = 2.06, P = 0.05). Chronic HBV-infected patients and HCC patients with genotype B had a significantly lower risk of A1762T/G1764A dual mutations compared with patients with genotype C (OR = 0.30, P < 0.0001 and OR = 0.34, P = 0.04, respectively). In HBV genotype C subjects, A1762T/G1764A dual mutations contributed to significantly higher risk for HCC developing compared with non-mutation ones (OR = 3.47, P < 0.00001). In conclusion, A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma, particularly in an HBV genotype C population, even without progression to cirrhosis.
authors: Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
authors: Zongguo
authors: Z
authors: Yang
authors: Fudan University Shanghai Cancer Center, Shanghai, China.|Shanghai Medical College, Fudan University, Shanghai, China.
authors: Liping
authors: L
authors: Zhuang
authors: Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
authors: Yunfei
authors: Y
authors: Lu
authors: Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
authors: Qingnian
authors: Q
authors: Xu
authors: Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
authors: Bozong
authors: B
authors: Tang
authors: Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
authors: Xiaorong
authors: X
authors: Chen
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000473:pathology / Q000821:virology*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000821:virology*; D009154:Mutation; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D014758:Viral Core Proteins / Q000235:genetics*
chemical_list: D014758:Viral Core Proteins
keywords: A1762T/G1764A; basal core promoter; hepatitis B virus X protein; hepatocellular carcinoma; mutation