title: Specification and function of hemogenic endothelium during embryogenesis.
abstract: Hemogenic endothelium is a specialized subset of developing vascular endothelium that acquires hematopoietic potential and can give rise to multilineage hematopoietic stem and progenitor cells during a narrow developmental window in tissues such as the extraembryonic yolk sac and embryonic aorta-gonad-mesonephros. Herein, we review current knowledge about the historical and developmental origins of hemogenic endothelium, the molecular events that govern hemogenic specification of vascular endothelial cells, the generation of multilineage hematopoietic stem and progenitor cells from hemogenic endothelium, and the potential for translational applications of knowledge gained from further study of these processes.
authors: Departments of Medicine, Genetics and Biomedical Engineering, Yale Cardiovascular Research Center, Vascular Biology and Therapeutics Program, and Yale Stem Cell Center, Yale University School of Medicine, 300 George St., New Haven, CT, 06511, USA.|Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Yale University School of Medicine, 333 Cedar St., New Haven, CT, 06511, USA.
authors: Emily
authors: E
authors: Gritz
authors: Departments of Medicine, Genetics and Biomedical Engineering, Yale Cardiovascular Research Center, Vascular Biology and Therapeutics Program, and Yale Stem Cell Center, Yale University School of Medicine, 300 George St., New Haven, CT, 06511, USA. karen.hirschi@yale.edu.
authors: Karen K
authors: KK
authors: Hirschi
mesh_terms: D047108:Embryonic Development; D004730:Endothelium, Vascular / Q000196:embryology*; D055018:Hemangioblasts / Q000166:cytology*; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology; D014212:Tretinoin / Q000378:metabolism
chemical_list: D014212:Tretinoin
keywords: Developmental hematopoiesis; Embryogenesis; Endothelial to hematopoietic transition; Hemogenic endothelium