title: Actinomycosis arising from the nasal cavity, with rare fatal progression.
abstract: Actinomycosis is a common treatable disease caused by Actinomyces, and generally has a good prognosis. However, we report a fatal case of actinomycosis of the nasal cavity. A 54-year-old man, reporting of left nasal obstruction, swelling and sharp pain around the root of the nose, was referred to our hospital. Histopathological examinations led to a definitive diagnosis of actinomycosis, and oral antibiotics were administered in an outpatient setting. However, the patient discontinued follow-up at the outpatient clinic because of the adverse effects of intravenous delivery, and poor compliance with oral antibiotic therapy led to him receiving a less than adequate dose. Thus, in the absence of sufficient antibiotic treatment, necrosis gradually progressed in the lesion, and the patient died of multiple organ failure and disseminated intravascular coagulation caused by local infection.
authors: Yokohama City University Medical Center, Yokohama, Japan.
authors: Yasunori
authors: Y
authors: Sakuma
authors: Yokohama City University Medical Center, Yokohama, Japan.
authors: Yukiko
authors: Y
authors: Yamashita
authors: Yokohama City University Medical Center, Yokohama, Japan.
authors: Osamu
authors: O
authors: Shiono
authors: Yokohama City University Medical Center, Yokohama, Japan.
authors: Nobuhiko
authors: N
authors: Oridate
mesh_terms: D000196:Actinomycosis / Q000175:diagnosis* / Q000188:drug therapy; D061605:Administration, Intravenous; D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D018450:Disease Progression; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000382:microbiology; D009668:Nose Diseases / Q000175:diagnosis* / Q000382:microbiology; D013407:Sulbactam / Q000008:administration & dosage / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin; D000658:Amoxicillin; D013407:Sulbactam