title: Quantitatively resolving multivalent interactions on a macroscopic scale using force spectroscopy.
abstract: Multivalent interactions remain difficult to be characterized and consequently controlled, particularly on a macroscopic scale. Using force-induced remnant magnetization spectroscopy (FIRMS), we have resolved the single-, double-, and triple-biotin-streptavidin interactions, multivalent DNA interactions and CXCL12-CXCR4 interactions on millimetre-scale surfaces. Our results establish FIRMS as a viable method for systematic resolution and controlled formation of multivalent interactions.
authors: Department of Chemistry, University of Houston, Houston, TX 77204, USA. sxu7@uh.edu.
authors: Qiongzheng
authors: Q
authors: Hu
authors: Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA. ywang60@uh.edu.
authors: Haopeng
authors: H
authors: Yang
authors: Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA. ywang60@uh.edu.
authors: Yuhong
authors: Y
authors: Wang
authors: Department of Chemistry, University of Houston, Houston, TX 77204, USA. sxu7@uh.edu.
authors: Shoujun
authors: S
authors: Xu
mesh_terms: D001710:Biotin / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D019809:Streptavidin / Q000737:chemistry*
chemical_list: D001710:Biotin; D004247:DNA; D019809:Streptavidin