title: The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila.
abstract: Understanding how organisms regulate their body size has interested biologists for decades. Recent work has shown that both insulin/target of rapamycin (TOR) signaling and the steroid hormone ecdysone act to regulate rates of growth and the duration of the growth period in the fruit fly, Drosophila melanogaster. Our recent work has uncovered a third level of interaction, whereby juvenile hormone (JH) regulates levels of both ecdysone and insulin/TOR signaling to control growth rates. These studies highlight a complex network of interactions involved in regulating body and organ size.
authors: Development, Evolution, and the Environment Laboratory; Instituto Gulbenkian de Ciência ; Oeiras, Portugal.
authors: Christen Kerry
authors: CK
authors: Mirth
authors: Department of Biology; Lake Forest College ; Lake Forest, IL USA.
authors: Alexander William
authors: AW
authors: Shingleton
keywords: body size; ecdysone; growth duration; growth rate; insulin/insulin-like growth factor signalling; juvenile hormone