title: Assessment of brain temperatures during different phases of the menstrual cycle using diffusion-weighted imaging thermometry.
abstract: OBJECTIVE
  To investigate changes in brain temperature according to the menstrual cycle in women using diffusion-weighted imaging (DWI) thermometry and to clarify relationships between brain and body temperatures.
  
  
  METHODS
  In 20 healthy female volunteers (21.3-38.8 years), DWI of the brain was performed during the follicular and luteal phases to calculate the brain temperature. During DWI, body temperatures were also measured. Group comparisons of each temperature between the two phases were performed using the paired t test. Correlations between brain and body temperatures were analyzed using Pearson's correlation coefficient test.
  
  
  RESULTS
  Mean diffusion-based brain temperature was 36.24 °C (follicular) and 36.96 °C (luteal), showing a significant difference (P < 0.0001). Significant differences were also seen for each body temperature between the two phases. Correlation coefficients between diffusion-based brain and each body temperature were r = 0.2441 (P = 0.1291), -0.0332 (0.8387), and -0.0462 (0.7769), respectively.
  
  
  CONCLUSIONS
  In women of childbearing age, brain and body temperatures appear significantly higher in the luteal than in the follicular phase. However, brain and body temperatures show no significant correlations.
authors: Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. ttsuka83@yahoo.co.jp.
authors: Taro
authors: T
authors: Tsukamoto
authors: Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
authors: Taro
authors: T
authors: Shimono
authors: Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
authors: Asari
authors: A
authors: Sai
authors: Advanced MR Imaging Research Laboratory, Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Koji
authors: K
authors: Sakai
authors: Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
authors: Akira
authors: A
authors: Yamamoto
authors: Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
authors: Shinichi
authors: S
authors: Sakamoto
authors: Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
authors: Yukio
authors: Y
authors: Miki
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology*; D062125:Thermometry / Q000379:methods*; D055815:Young Adult
keywords: Brain temperature; Diffusion-weighted imaging; Menstrual cycle; Thermometry