title: The rise, fall, and possible resurrection of renal denervation.
abstract: Renal denervation has a chequered history. Dramatic reductions in blood pressure after denervation of the renal arteries were observed in early trials, but later trials in which denervation was tested against a sham procedure produced neutral results. Although a sound pathophysiological basis exists for interruption of the renal sympathetic nervous system as a treatment for hypertension, trial data to date are insufficient to support renal denervation as an established clinical therapy. In this Perspectives article, we summarize the currently available trial data, device development, and trials in progress, and provide recommendations for future trial design.
authors: Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic, 200 First Street, Rochester, Minnesota 55905, USA.
authors: Rajiv
authors: R
authors: Gulati
authors: NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, Sydney Street, London SW3 6NP, UK.
authors: Claire E
authors: CE
authors: Raphael
authors: Medtronic Inc, 3576 Unocal Place, Santa Rosa, California 95403, USA.
authors: Manuela
authors: M
authors: Negoita
authors: London School of Hygiene and Tropical Medicine, Keppel Street, London WZ1E 7HT, UK.
authors: Stuart J
authors: SJ
authors: Pocock
authors: Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic, 200 First Street, Rochester, Minnesota 55905, USA.
authors: Bernard J
authors: BJ
authors: Gersh
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004351:Drug Resistance; D019317:Evidence-Based Medicine; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D007668:Kidney / Q000294:innervation*; D013562:Sympathectomy / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents