title: Successful living donor intestinal transplantation in cross-match positive recipients: Initial experience.
abstract: Sensitized patients tend to have longer waiting times on the deceased donor list and are at increased risk of graft loss from acute or chronic rejection compared to non-sensitized candidates. Desensitization protocols are utilized to decrease the levels of alloantibodies and to convert an initial positive cross-match to prospective donors into a negative crossmatch. These procedures are mostly available in the setting of living donation. Due to the elective nature of the procedure, desensitization protocols can be extended until the desire result is obtained prior to transplantation. We present two cases of successful desensitization protocol applied to living donor intestinal transplant candidates that converted to negative cross-match to their donors. We present two cases of intestinal transplant candidates with a potential living donor to whom they are sensitized. Both cases underwent successful transplantation after desensitization protocol. No evidence of humoral rejection has occurred in either recipient. Living donor intestinal transplantation in sensitized recipients against the prospective donors provides the ability to implement a desensitization protocol to convert to negative cross-match.
authors: Raquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
authors: Raquel
authors: R
authors: Garcia-Roca
authors: Raquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
authors: Ivo G
authors: IG
authors: Tzvetanov
authors: Raquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
authors: Hoonbae
authors: H
authors: Jeon
authors: Raquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
authors: Elisabeth
authors: E
authors: Hetterman
authors: Raquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
authors: Jose
authors: J
authors: Oberholzer
authors: Raquel Garcia-Roca, Ivo G Tzvetanov, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems, Chicago, IL 60622, United States.
authors: Enrico
authors: E
authors: Benedetti
keywords: Desensitization protocol; Donor specific antibody; Intestinal transplant; Living donor; Plasmapheresis; Positive crossmatch