title: Punctiform and Polychromatophilic Dominant Pre-Descemet Corneal Dystrophy.
abstract: OBJECTIVE
  To describe the slit-lamp appearance and corneal confocal microscopy of autosomal dominant punctiform and polychromatophilic pre-Descemet corneal dystrophy in 3 members of the same family.
  
  
  METHODS
  Slit-lamp examination of a 9-year-old boy showed bilateral polychromatophilic corneal opacities in a pre-Descemet membrane location evenly deposited limbus to limbus, both horizontally and vertically, with an intervening clear cornea. The corneal endothelium was normal on corneal confocal microscopy, with hyperreflective opacities of various sizes located pre-Descemet membrane. Slit-lamp examination of the patient's father and brother revealed identical crystalline deposition in the pre-Descemet corneal stroma. The remainders of the eye examinations were otherwise normal in all 3 individuals, and all were asymptomatic.
  
  
  RESULTS
  The general physical examination and laboratory investigations of the patient were all normal, as were the laboratory investigations of the other 2 family members. There was no progression in the corneal findings over 6 months of follow-up.
  
  
  CONCLUSIONS
  These patients likely illustrate a rare autosomal dominant pre-Descemet crystalline keratopathy that has been reported only once previously.
authors: *Ophthalmology and †Nephrology, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada; and ‡Pediatric Ophthalmology, Kellogg Eye Center, University of Michigan, Ann Arbor, MI.
authors: Lisa
authors: L
authors: Lagrou
authors: Julian
authors: J
authors: Midgley
authors: Kenneth Gerald
authors: KG
authors: Romanchuk
mesh_terms: D002648:Child; D003317:Corneal Dystrophies, Hereditary / Q000175:diagnosis; D003319:Corneal Stroma / Q000473:pathology*; D003886:Descemet Membrane / Q000473:pathology*; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal; D066167:Slit Lamp; D014792:Visual Acuity