title: Intracranial Atherosclerosis and Poststroke Depression in Chinese Patients with Ischemic Stroke.
abstract: BACKGROUND
  Intracranial atherosclerosis (ICAS) is a common etiology of ischemic stroke in Chinese patients, probably leading to regional hypoperfusion in the brain. The purpose of this prospective study was to investigate the association between ICAS and poststroke depression in Chinese patients with ischemic stroke.
  
  
  METHODS
  During the study period, a total of 569 patients aged between 40 and 80 years with acute ischemic stroke were consecutively admitted and screened. Patients with a National Institutes of Health Stroke Scale (NIHSS) total score of 15 or higher, with severe cognitive impairment, or with a history of depression before stroke were excluded. Two hundred seven patients with ischemic stroke were consecutively recruited in the study. Depressive symptoms were assessed in the acute stage and 3 months after stroke. Poststroke depression was defined as a score of 8 or higher in the 24-item Hamilton Depression Rating Scale. The evaluation of the magnetic resonance imaging scans focused on infarctions, white matter lesions, brain atrophy, and ICAS.
  
  
  RESULTS
  In the acute stage of stroke, logistic regression revealed that female sex, NIHSS score at admission, prestroke insomnia, and ICAS were significant predictors of poststroke depression. At 3 months after stroke, prestroke insomnia, the Mini-Mental State Examination score and ICAS were significant predictors of poststroke depression.
  
  
  CONCLUSIONS
  ICAS may be a significant independent predictor of poststroke depression in Chinese patients with ischemic stroke.
authors: Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong Province, China. Electronic address: cykun78@163.com.
authors: Yang-Kun
authors: YK
authors: Chen
authors: Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong Province, China.
authors: Jian-Feng
authors: JF
authors: Qu
authors: Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong Province, China.
authors: Wei-Min
authors: WM
authors: Xiao
authors: Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong Province, China.
authors: Wan-Yi
authors: WY
authors: Li
authors: Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong Province, China.
authors: Wei
authors: W
authors: Li
authors: Department of Radiology, Dongguan People's Hospital, Dongguan, Guangdong Province, China.
authors: Xue-Wen
authors: XW
authors: Fang
authors: Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong Province, China.
authors: Han-Yu
authors: HY
authors: Weng
authors: Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong Province, China.
authors: Yong-Lin
authors: YL
authors: Liu
authors: Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong Province, China.
authors: Gen-Pei
authors: GP
authors: Luo
authors: School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia; The University of Notre Dame Australia/Marian Centre, Perth, Western Australia, Australia.
authors: Gabor S
authors: GS
authors: Ungvari
authors: Faculty of Health Sciences, University of Macau, Macao SAR, China.
authors: Yu-Tao
authors: YT
authors: Xiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002545:Brain Ischemia / Q000150:complications; D003072:Cognition Disorders / Q000209:etiology; D003863:Depression / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D002537:Intracranial Arteriosclerosis / Q000000981:diagnostic imaging / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D020521:Stroke / Q000150:complications* / Q000000981:diagnostic imaging / Q000209:etiology
keywords: Depression; cerebrovascular disease; emotional disorder; intracranial atherosclerosis; stroke