title: Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study.
abstract: BACKGROUND
  Hepatic steatosis confers an increased risk of metabolic and cardiovascular disease and higher health services use. Associations of the single nucleotide polymorphisms (SNP) PNPLA3 rs738409 and TM6SF2 rs58542926 with hepatic steatosis have recently been established. This study investigates the association between rs738409 and rs58542926 with health services utilization in a general population.
  
  
  METHODS
  Data of 3759 participants from Study of Health in Pomerania (SHIP), a population-based study in Germany, were obtained. The annual number of outpatient visits, hospitalization and length of hospital stay was regressed on rs738409 and rs58542926 and adjusted for socio-economic factors, lifestyle habits, clinical factors, and health status.
  
  
  RESULTS
  Minor allele homozygous subjects of rs738409 had an increased odds of hospitalization as compared to major allele homozygous subjects (odds ratio [OR] 1.51; 95% confidence interval [CI], 1.02 to 2.15). Heterozygous subjects did not differ from major allele homozygous subjects with respect to their odds of hospitalization. The three genotype groups of rs738409 were similar with respect to the number of outpatient visits and inpatient days. Minor allele homozygous and heterozygous subjects of rs58542926 had higher outpatient utilization (+53.04% and +67.56%, p < 0.05, respectively) and inpatient days than major allele homozygous subjects.
  
  
  CONCLUSIONS
  After adjustment for several confounding factors, PNPLA3 rs738409 and TM6SF2 rs58542926 were associated with the number of outpatient visits, hospitalization, and inpatient days. Further studies are warranted to replicate our findings and to evaluate whether genetic data can be used to identify subjects with excess health services utilization.
authors: Department of Community Medicine, University Medicine Greifswald, Walther-Rathenau-Straße 48, 17475, Greifswald, Germany.
authors: Julia
authors: J
authors: Köpp
authors: Department of Health Care Management, Ernst Moritz Arndt University of Greifswald, Friedrich-Loeffler-Straße 70, 17489, Greifswald, Germany.
authors: Steffen
authors: S
authors: Fleßa
authors: Institute for Epidemiology, Christian Albrechts University, Niemannsweg 11, 24105, Kiel Kiel, Germany.
authors: Wolfgang
authors: W
authors: Lieb
authors: Department of Community Medicine, University Medicine Greifswald, Walther-Rathenau-Straße 48, 17475, Greifswald, Germany.
authors: Marcello Ricardo Paulista
authors: MRP
authors: Markus
authors: Department of Community Medicine, University Medicine Greifswald, Walther-Rathenau-Straße 48, 17475, Greifswald, Germany.
authors: Alexander
authors: A
authors: Teumer
authors: Department of Functional Genomics, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany.
authors: Georg
authors: G
authors: Homuth
authors: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany.
authors: Henri
authors: H
authors: Wallaschofski
authors: Department of Health Care Management, Ernst Moritz Arndt University of Greifswald, Friedrich-Loeffler-Straße 70, 17489, Greifswald, Germany.
authors: Paul
authors: P
authors: Marschall
authors: Department of Community Medicine, University Medicine Greifswald, Walther-Rathenau-Straße 48, 17475, Greifswald, Germany.
authors: Henry
authors: H
authors: Völzke
authors: Department of Community Medicine, University Medicine Greifswald, Walther-Rathenau-Straße 48, 17475, Greifswald, Germany. sebastian.baumeister@ukr.de.|Institute for Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, D-93053, Regensburg, Germany. sebastian.baumeister@ukr.de.
authors: Sebastian Edgar
authors: SE
authors: Baumeister
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D005838:Genotype; D005858:Germany; D006296:Health Services / Q000706:statistics & numerical data*; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000235:genetics; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018570:Risk Assessment; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent
chemical_list: D008049:Lipase; D008565:Membrane Proteins; C419195:TM6SF2 protein, human; C533682:PNPLA3 protein, human; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent