title: [Agranulocytosis and septic shock after metamizole use].
abstract: BACKGROUND
  Metamizole is an analgesic, the orally administered form of which was withdrawn in the Netherlands in 1989 due to an unacceptably high incidence of agranulocytosis. However, later studies showed a much lower incidence and since 2013 the use of metamizole has been recommended by the national guideline on postoperative pain.
  
  
  METHODS
  A 58-year-old woman was referred by her general practitioner to our hospital with suspected diverticulitis. Three days previously the patient had returned from a four-week period of rehabilitation at a German spa following hip replacement surgery. She had been using metamizole since the operation. Within hours of admission, the patient developed septic shock and was transferred to the intensive care unit. Laboratory tests revealed severe neutropenia of 0.2 × 10(9)/l. Treatment consisted of filgrastim, piperacillin/tazobactam and haemodynamic support. After five days the patient was sufficiently recovered to return to the ward.
  
  
  CONCLUSIONS
  Metamizole-related agranulocytosis is rare but potentially life-threatening. This condition is expected to occur more frequently as the use of metamizole in the Netherlands increases.
authors: Medisch Spectrum Twente, Enschede.
authors: Thijs H
authors: TH
authors: Oude Munnik
authors: Marjon
authors: M
authors: Annink-Smoors
authors: Harold W
authors: HW
authors: Hom
authors: Esther T
authors: ET
authors: Sportel
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced* / Q000175:diagnosis; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects*; D019644:Arthroplasty, Replacement, Hip / Q000379:methods; D004177:Dipyrone / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009503:Neutropenia; D010149:Postoperative Pain / Q000188:drug therapy; D012772:Shock, Septic / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000700:Analgesics; D004177:Dipyrone