title: [EFFECT OF FUCOIDANS ISOLATED FROM SEAWEEDS LAMINARIA DIGITATA AND FUCUS VESICULOSUS ON CELL LINES HELA G-63, ECV 304 AND PC 12].
abstract: The aim of the research was to investigate cytotoxicity of fucoidans on mammals cells. Three different samples of fucoidans were isolated from mechanically grounded brown algae Laminaria digitata and Fucus ve- siculosus. The sample F2 that differed from the others by higher sulfatation level and suppression of HeLa G-63 line culture growth was taken for further study in cell lines HeLa G-63, ECV 304 and PC 12. We have shown that fucoidan preparation F2 inhibits proliferation and induces cell death in a dose- and time-dependent manner for all investigated cell lines. Neuroendocrine tumor rat cell line PC 12 appeared to be the most sensitive to fucoidan treatment whereas endothelial human cells ECV 304 were the least sensitive.
authors: E V
authors: EV
authors: Zhurishkina
authors: I M
authors: IM
authors: Lapina
authors: D R
authors: DR
authors: Ivanen
authors: S I
authors: SI
authors: Stepanov
authors: S V
authors: SV
authors: Shvetsova
authors: A L
authors: AL
authors: Shavarda
authors: N Ya
authors: NY
authors: Giliano
authors: A A
authors: AA
authors: Kulminskaya
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D042783:Endothelial Cells / Q000187:drug effects; D044645:Fucus / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007795:Laminaria / Q000737:chemistry; D016716:PC12 Cells; D011134:Polysaccharides / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D012624:Seaweed / Q000737:chemistry
chemical_list: D011134:Polysaccharides; C007789:fucoidan