title: Constituents from Polygonatum sibiricum and their inhibitions on the formation of advanced glycosylation end products.
abstract: A new saponin, isonarthogenin 3-O-β-d-glucopyranosyl-(1→4)-β-d-galactopyranoside (1), together with twelve known compounds, were isolated from the rhizomes of Polygonatum sibiricum. The structures of these compounds were elucidated by analysis of their 1D/2D NMR and MS data. Among them, phenol compounds 4-7 and 9-10 showed significant inhibitions against the formation of advanced glycosylation end products, with IC50 values of 0.091 ± 0.0021, 0.10 ± 0.041, 0.014 ± 0.0027, 0.11 ± 0.011, 0.13 ± 0.045, and 0.055 ± 0.019 μM, respectively. The results will promote exploiting potential medicinal use of these compounds in the prevention of diabetic complications and supporting Polygonatum sibiricum as a functional food for healthy and medicinal diet.
authors: a Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis , Tianjin University of Traditional Chinese Medicine , Tianjin , 300457 , China.|b Research and Development Center of TCM , Tianjin International Joint Academy of Biotechnology & Medicine , Tianjin , 300457 , China.
authors: Juan
authors: J
authors: Wang
authors: a Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis , Tianjin University of Traditional Chinese Medicine , Tianjin , 300457 , China.|b Research and Development Center of TCM , Tianjin International Joint Academy of Biotechnology & Medicine , Tianjin , 300457 , China.
authors: Cheng-Shu
authors: CS
authors: Lu
authors: b Research and Development Center of TCM , Tianjin International Joint Academy of Biotechnology & Medicine , Tianjin , 300457 , China.
authors: Dong-Yan
authors: DY
authors: Liu
authors: a Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis , Tianjin University of Traditional Chinese Medicine , Tianjin , 300457 , China.|b Research and Development Center of TCM , Tianjin International Joint Academy of Biotechnology & Medicine , Tianjin , 300457 , China.
authors: Yan-Tong
authors: YT
authors: Xu
authors: a Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis , Tianjin University of Traditional Chinese Medicine , Tianjin , 300457 , China.|b Research and Development Center of TCM , Tianjin International Joint Academy of Biotechnology & Medicine , Tianjin , 300457 , China.
authors: Yan
authors: Y
authors: Zhu
authors: a Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis , Tianjin University of Traditional Chinese Medicine , Tianjin , 300457 , China.|b Research and Development Center of TCM , Tianjin International Joint Academy of Biotechnology & Medicine , Tianjin , 300457 , China.
authors: Hong-Hua
authors: HH
authors: Wu
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031384:Polygonatum / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D017127:Glycation End Products, Advanced; D012503:Saponins; C000613437:isonarthogenin 3-O-beta-D-glucopyranosyl-(1-4)-beta-D-galactopyranoside
keywords: AGEs; Liliaceae; Polygonatum sibiricum; diabetes; phenolic compounds; saponin