title: The role of antithyroglobulin, antiperoxidase and anti-TSH receptor autoantibodies in amiodarone-induced thyrotoxicosis and amiodarone-induced hypothyroidism (A two-center study).
abstract: OBJECTIVE
  It has been reported that patients experiencing side effects of amiodarone (AM) therapy, such as amiodarone-induced thyrotoxocosis (AIT) or amiodarone-induced hypothyroidism (AIH), have changes in serum concentrations of anti-TSH receptor (TSHR), antithyroglobulin (Tg), and antiperoxidase (TPO) autoantibodies (Abs). The purpose of our study was to identify and analyze the changes in levels of listed antibodies in patients with several thyroid disorders.
  
  
  METHODS
  280 patients from two centers in Poland were included. Titers of TSHR-Abs, TPO-Abs and Tg-Abs were analyzed retrospectively in the following groups of patients: A - euthyroid patients with a history of hyperthyroidism prior to re-administration of AM; B - patients with AIT who discontinued the AM therapy; C - patients with AIT chronically treated with AM; D - hypothyroid patients.
  
  
  RESULTS
  Serum Tg-Abs were not elevated in any of the studied groups. However, there were significant differences between A and B and also D and other groups (p<0.05). TPO-Abs titers were not elevated in most cases, there were no significant differences between groups. The serum titers of TSHR-Abs were not elevated in any group. We found statistically significant differences between B and D, C and other groups (p<0.05).
  
  
  CONCLUSIONS
  Regardless of the statistically significant differences observed for Tg-Abs and TSHR-Abs levels, this observation have a limited clinical applicability. In almost all cases we observed normal to slightly increased titers of TPO-Abs, Tg-Abs, TSHR-Abs. Discontinuation or continuation of AM therapy had no influence on autoantibody titers. Furthermore, we found it impossible to differentiate between the type I and II of AIT based on autoantibody titers.
authors: Department of Pharmacology, Poznan University of Medical Sciences, ul Rokietnicka 5a, 60 806 Poznan, Poland.
authors: Agata
authors: A
authors: Czarnywojtek
authors: Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, ul. Marymoncka 99/103, 01-813 Warszawa, Poland.
authors: Barbara
authors: B
authors: Czarnocka
authors: Laboratory of Medical Electrodiagnostics, Department of Health Prophylaxis, Poznan University of Medical Sciences, Poland.
authors: Małgorzata
authors: M
authors: Zgorzalewicz-Stachowiak
authors: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.
authors: Kosma
authors: K
authors: Wolinski
authors: Department of Pharmacology, Poznan University of Medical Sciences, ul Rokietnicka 5a, 60 806 Poznan, Poland.
authors: Marta
authors: M
authors: Fichna
authors: Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.
authors: Maria Teresa
authors: MT
authors: Plazinska
authors: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.
authors: Adam
authors: A
authors: Stangierski
authors: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.
authors: Pawel
authors: P
authors: Gut
authors: Department of Computer Science and Statistics, University of Medical Sciences in Poznan, Poznan, Poland.
authors: Izabela
authors: I
authors: Miechowicz
authors: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.
authors: Hanna
authors: H
authors: Komarowska
authors: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.
authors: Joanna
authors: J
authors: Waligorska-Stachura
authors: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.
authors: Ryszard
authors: R
authors: Wasko
authors: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.
authors: Marek
authors: M
authors: Ruchala