title: Pulmonary functions in children with inflammatory bowel disease.
abstract: OBJECTIVE
  To investigate fractional exhaled nitric-oxide (FeNO) levels in children with Crohn's disease (CD) and ulcerative colitis (UC) and their correlation to disease activity.
  
  
  METHODS
  Children with CD and UC (aged 8-18 years) and age-matched healthy controls without respiratory symptoms were recruited. Disease activity was assessed using validated scores. All children performed spirometry and FeNO tests and the association between intestinal disease parameters and pulmonary functions was studied.
  
  
  RESULTS
  Thirty-five children with CD, nine with UC, and 24 healthy controls were enrolled. The mean FeNO level was higher in children with CD compared with the controls. Increased FeNO levels (>23 parts per billion) were more common among CD and UC compared with healthy children (46, 33, and 0%, respectively, P<0.05). Nevertheless, FeNO levels did not correlate with disease activity. There were no significant differences between CD, UC patients, and healthy controls in any of the spirometric variables.
  
  
  CONCLUSIONS
  FeNO level, a marker of airway inflammation, is elevated in children with inflammatory bowel diseases irrespective of their intestinal disease activity. Increased FeNO levels are not associated with respiratory symptoms, suggesting a latent pulmonary involvement in the systemic disease.
authors: Departments of aPediatric Pulmonology, Critical Care and Sleep Medicine bPediatric Gastroenterology, 'Dana-Dwek' Children's Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Guy
authors: G
authors: Gut
authors: Amir
authors: A
authors: Ben-Tov
authors: Avishai
authors: A
authors: Lahad
authors: Ruth
authors: R
authors: Soferman
authors: Shlomi
authors: S
authors: Cohen
authors: Riva
authors: R
authors: Tauman
authors: Yakov
authors: Y
authors: Sivan
mesh_terms: D000293:Adolescent; D001944:Breath Tests; D016022:Case-Control Studies; D002648:Child; D003093:Colitis, Ulcerative / Q000503:physiopathology*; D003424:Crohn Disease / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D012720:Severity of Illness Index; D013147:Spirometry; D014797:Vital Capacity
chemical_list: D009569:Nitric Oxide