title: A Reanalysis of Cognitive-Functional Performance in Older Adults: Investigating the Interaction Between Normal Aging, Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Depression.
abstract: Depressive symptoms are associated with cognitive-functional impairment in normal aging older adults (NA). However, less is known about this effect on people with mild Cognitive Impairment (MCI) and mild Alzheimer's disease dementia (AD). We investigated this relationship along with the NA-MCI-AD continuum by reanalyzing a previously published dataset. Participants (N = 274) underwent comprehensive neuropsychological assessment including measures of Executive Function, Language/Semantic Memory, Episodic Memory, Visuospatial Abilities, Activities of Daily Living (ADL), and the Geriatric Depression Scale. MANOVA, logistic regression and chi-square tests were performed to assess the association between depression and cognitive-functional performance in each group. In the NA group, depressed participants had a lower performance compared to non-depressed participants in all cognitive and functional domains. However, the same pattern was not observed in the MCI group or in AD. The results suggest a progressive loss of association between depression and worse cognitive-functional performance along the NA-MCI-AD continuum.
authors: Faculdade de Medicina, Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Universidade Federal de Minas GeraisBelo Horizonte, Brazil; Department of Psychology, Faculdade de Ciências Médicas de Minas GeraisBelo Horizonte, Brazil.
authors: Jonas J
authors: JJ
authors: de Paula
authors: Faculdade de Medicina, Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Universidade Federal de Minas GeraisBelo Horizonte, Brazil; Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas GeraisBelo Horizonte, Brazil; Reference Center for Geriatrics Instituto Jenny de Andrade Faria, Universidade Federal de Minas GeraisBelo Horizonte, Brazil.
authors: Maria A
authors: MA
authors: Bicalho
authors: Faculdade de Medicina, Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Universidade Federal de Minas GeraisBelo Horizonte, Brazil; Reference Center for Geriatrics Instituto Jenny de Andrade Faria, Universidade Federal de Minas GeraisBelo Horizonte, Brazil.
authors: Rafaela T
authors: RT
authors: Ávila
authors: Reference Center for Geriatrics Instituto Jenny de Andrade Faria, Universidade Federal de Minas Gerais Belo Horizonte, Brazil.
authors: Marco T G
authors: MT
authors: Cintra
authors: Faculdade de Medicina, Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Universidade Federal de Minas GeraisBelo Horizonte, Brazil; Department of Mental Health, Faculdade de Medicina, Universidade Federal de Minas GeraisBelo Horizonte, Brazil.
authors: Breno S
authors: BS
authors: Diniz
authors: Faculdade de Medicina, Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Universidade Federal de Minas GeraisBelo Horizonte, Brazil; Department of Mental Health, Faculdade de Medicina, Universidade Federal de Minas GeraisBelo Horizonte, Brazil.
authors: Marco A
authors: MA
authors: Romano-Silva
authors: Faculdade de Medicina, Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Universidade Federal de Minas GeraisBelo Horizonte, Brazil; Department of Mental Health, Faculdade de Medicina, Universidade Federal de Minas GeraisBelo Horizonte, Brazil.
authors: Leandro F
authors: LF
authors: Malloy-Diniz
keywords: Alzheimer's disease; activities of daily living; cognitive assessment; depression; mild cognitive impairment; neuropsychological assessment; older adults