title: Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study.
abstract: OBJECTIVE
  The objective of the present study was to examine the associations between metabolic syndrome (MS) components, such as overweight (OW), hypertension (HT), dyslipidemia (DL), and impaired glucose tolerance (IGT), and intervertebral disc degeneration (DD).
  
  
  METHODS
  The present study included 928 participants (308 men, 620 women) of the 1,011 participants in the Wakayama Spine Study. DD on magnetic resonance imaging was classified according to the Pfirrmann system. OW, HT, DL, and IGT were assessed using the criteria of the Examination Committee of Criteria for MS in Japan.
  
  
  RESULTS
  Multivariable logistic regression analysis revealed that OW was significantly associated with cervical, thoracic, and lumbar DD (cervical: odds ratio [OR], 1.28; 95% confidence interval [CI], 0.92-1.78; thoracic: OR, 1.75; 95% CI, 1.24-2.51; lumbar: OR, 1.87; 95% CI, 1.06-3.48). HT and IGT were significantly associated with thoracic DD (HT: OR, 1.54; 95% CI, 1.09-2.18; IGT: OR, 1.65; 95% CI, 1.12-2.48). Furthermore, subjects with 1 or more MS components had a higher OR for thoracic DD compared with those without MS components (vs. no component; 1 component: OR, 1.58; 95% CI, 1.03-2.42; 2 components: OR, 2.60; 95% CI, 1.62-4.20; ≥3 components: OR, 2.62; 95% CI, 1.42-5.00).
  
  
  CONCLUSIONS
  MS components were significantly associated with thoracic DD. Furthermore, accumulation of MS components significantly increased the OR for thoracic DD. These findings support the need for further studies of the effects of metabolic abnormality on DD.
authors: Department of Orthopaedic surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
authors: Masatoshi
authors: M
authors: Teraguchi
authors: Department of Joint Disease Research, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Noriko
authors: N
authors: Yoshimura
authors: Department of Orthopaedic surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
authors: Hiroshi
authors: H
authors: Hashizume
authors: Department of Joint Disease Research, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Shigeyuki
authors: S
authors: Muraki
authors: Department of Orthopaedic surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
authors: Hiroshi
authors: H
authors: Yamada
authors: Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Hiroyuki
authors: H
authors: Oka
authors: Department of Orthopaedic surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
authors: Akihito
authors: A
authors: Minamide
authors: Department of Orthopaedic surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
authors: Yuyu
authors: Y
authors: Ishimoto
authors: Department of Orthopaedic surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
authors: Keiji
authors: K
authors: Nagata
authors: Department of Orthopaedic surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
authors: Ryohei
authors: R
authors: Kagotani
authors: Department of Orthopaedic surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Sakae
authors: S
authors: Tanaka
authors: Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, 5-1 Tsukudo-chome, Shinjuku-ku, Tokyo, 162-8543, Japan.
authors: Hiroshi
authors: H
authors: Kawaguchi
authors: Rehabilitation Services Bureau, National Rehabilitation Center for Persons with Disabilities, 1 Namiki 4-chome, Tokorozawa City, Saitama, 359-8555, Japan.
authors: Kozo
authors: K
authors: Nakamura
authors: Rehabilitation Services Bureau, National Rehabilitation Center for Persons with Disabilities, 1 Namiki 4-chome, Tokorozawa City, Saitama, 359-8555, Japan.
authors: Toru
authors: T
authors: Akune
authors: Department of Orthopaedic surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
authors: Munehito
authors: M
authors: Yoshida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001794:Blood Pressure; D050171:Dyslipidemias; D005260:Female; D018149:Glucose Intolerance; D006801:Humans; D006973:Hypertension; D055959:Intervertebral Disc Degeneration / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D050177:Overweight; D015995:Prevalence; D013131:Spine / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: D015415:Biomarkers