title: Molecular Mechanisms of Nickel Allergy.
abstract: Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are known to produce an allergic reaction, nickel is the most frequent cause of metal allergy. Researchers have attempted to elucidate the mechanisms of metal allergy using animal models and human patients. Here, the immunological and molecular mechanisms of metal allergy are described based on the findings of previous studies, including those that were recently published. In addition, the adsorption and excretion of various metals, in particular nickel, is discussed to further understand the pathogenesis of metal allergy.
authors: Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. m.saito@tokushima-u.ac.jp.
authors: Masako
authors: M
authors: Saito
authors: Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. arakaki.r@tokushima-u.ac.jp.
authors: Rieko
authors: R
authors: Arakaki
authors: Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. aki.yamada@tokushima-u.ac.jp.
authors: Akiko
authors: A
authors: Yamada
authors: Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. tsunematsu@tokushima-u.ac.jp.
authors: Takaaki
authors: T
authors: Tsunematsu
authors: Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. yasusei@tokushima-u.ac.jp.
authors: Yasusei
authors: Y
authors: Kudo
authors: Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. ishimaru.n@tokushima-u.ac.jp.
authors: Naozumi
authors: N
authors: Ishimaru
mesh_terms: D000485:Allergens / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000378:metabolism*; D017136:Ion Transport; D009532:Nickel / Q000378:metabolism / Q000633:toxicity*; D013950:Thymus Gland / Q000187:drug effects; D014131:Trace Elements / Q000378:metabolism / Q000633:toxicity*
chemical_list: D000485:Allergens; D014131:Trace Elements; D009532:Nickel
keywords: DC; DTH; Ni; T cell; TLR; TSLP; metal allergy