title: Phage M13 for the treatment of Alzheimer and Parkinson disease.
abstract: The studies of microbes have been instrumental in combatting infectious diseases, but they have also led to great insights into basic biological mechanism like DNA replication, transcription, and translation of mRNA. In particular, the studies of bacterial viruses, also called bacteriophage, have been quite useful to study specific cellular processes because of the ease to isolate their DNA, mRNA, and proteins. Here, I review the recent discovery of how properties of the filamentous phage M13 emerge as a novel approach to combat neurodegenerative diseases.
authors: Waksman Institute of Microbiology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. Electronic address: messing@waksman.rutgers.edu.
authors: Joachim
authors: J
authors: Messing
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D017104:Bacteriophage M13 / Q000502:physiology*; D001691:Biological Therapy / Q000379:methods; D061505:Cell Surface Display Techniques; D004926:Escherichia coli / Q000821:virology; D015870:Gene Expression; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D058225:Plaque, Amyloid / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D011228:Prealbumin / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D011328:Prions / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D066263:Protein Aggregation, Pathological / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D011485:Protein Binding; D051843:Synucleins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D014764:Viral Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D016875:tau Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D011228:Prealbumin; D011328:Prions; D051843:Synucleins; D014764:Viral Proteins; D016875:tau Proteins
keywords: Alzheimer disease; Bacteriophage M13; Parkinson disease