title: Long-lived anomalous thermal diffusion induced by elastic cell membranes on nearby particles.
abstract: The physical approach of a small particle (virus, medical drug) to the cell membrane represents the crucial first step before active internalization and is governed by thermal diffusion. Using a fully analytical theory we show that the stretching and bending of the elastic membrane by the approaching particle induces a memory in the system, which leads to anomalous diffusion, even though the particle is immersed in a purely Newtonian liquid. For typical cell membranes the transient subdiffusive regime extends beyond 10 ms and can enhance residence times and possibly binding rates up to 50%. Our analytical predictions are validated by numerical simulations.
authors: Biofluid Simulation and Modeling, Fachbereich Physik, Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany.
authors: Abdallah
authors: A
authors: Daddi-Moussa-Ider
authors: Biofluid Simulation and Modeling, Fachbereich Physik, Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany.
authors: Achim
authors: A
authors: Guckenberger
authors: Biofluid Simulation and Modeling, Fachbereich Physik, Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany.
authors: Stephan
authors: S
authors: Gekle
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D003198:Computer Simulation; D004548:Elasticity; D004705:Endocytosis / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D052898:Optical Tweezers; D055471:Thermal Diffusion; D014783:Viscosity