title: Effects of multiwalled carbon nanotubes on electrospun poly(lactide-co-glycolide)-based nanocomposite scaffolds on neural cells proliferation.
abstract: The repair of nerves remains a major challenge in neuron-regeneration. In this study, poly(lactic-co-glycolic acid)/multi-walled carbon nanotubes (PLGA/MWCNTs) nanofibrous scaffolds were fabricated by electrospinning method. The surface morphology, physical, and mechanical properties were characterized through scanning electron microscopy (SEM), transmission electron microscopy, and tensile tests, respectively. SEM analysis, Live/Dead staining, immunostaining assays were performed to evaluate neural cells growth. Blending PLGA with MWCNTs resulted in increase diameter and porosity of the scaffolds, and exhibited better mechanical properties. The results demonstrated that the scaffolds with higher MWCNTs concentration provided better survival for neural cells after 8 days of culture, especially for astrocytes growth. This could be useful in treating the disease like multiple sclerosis that causing central nervous system demyelination and axonal injury. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 934-943, 2017.
authors: Regenerative Medicine Center, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.|Queen Mary University of London, London, E1 4NS, United Kingdom.
authors: Zheng Jun
authors: ZJ
authors: Lv
authors: Regenerative Medicine Center, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.
authors: Yang
authors: Y
authors: Liu
authors: Regenerative Medicine Center, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.
authors: Hui
authors: H
authors: Miao
authors: Regenerative Medicine Center, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.|Department of Operation Room, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.
authors: Zhi Qian
authors: ZQ
authors: Leng
authors: Regenerative Medicine Center, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.
authors: Jian Hui
authors: JH
authors: Guo
authors: Regenerative Medicine Center, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.
authors: Jing
authors: J
authors: Liu
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000648:ultrastructure; D049109:Cell Proliferation; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D011098:Polyglactin 910 / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D011098:Polyglactin 910
keywords: PLGA; carbon nanotube; electrospinning; glial cells; nerve regeneration; neuron