title: Functionalized Magnetic Nanostructures for Anticancer Therapy.
abstract: In the last years, the production and applications of nanoparticles based on iron oxides in the field of biomedicine presented a great interest due to their particular properties. Because of the expansion of the pharmaceutical industry numerous new systems for drugs delivery have appeared, and those centered on magnetic nanoparticles are in a particular attention and in different promising developmental stages.
  
  
  
  In this mini review, some representative, interesting and feasible magnetic nanostructures obtained recently (from last 5-6 years) with possible use in antitumor/anticancer therapy are presented.
  
  
  
  The synthesis of these nanostructures with magnetic properties implies very simple assembling procedures and presents one of the lowest cytotoxic profiles. Magnetic nanostructures displayed possible appliance in a large diversity of biotechnological and medical fields, both for diagnose and therapy.
  
  
  
  Different types of magnetic nano-carriers loaded with different antitumor/anticancer agents and the cases tested in vivo are considered.
authors: Centre of Bioanalysis, National Institute for Biological Sciences, Bucharest, Romania.
authors: Eugenia Dumitra
authors: ED
authors: Teodor
authors: Centre of Bioanalysis, National Institute for Biological Sciences, Bucharest, Romania.
authors: Florentina
authors: F
authors: Gatea
authors: Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Bucharest, Romania.
authors: Anton
authors: A
authors: Ficai
authors: Department of Analytical Chemistry and Instrumental Analysis, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania.
authors: Gabriel Lucian
authors: GL
authors: Radu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D006801:Humans; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles
keywords: Functionalized magnetic nanostructures; anticancer therapy; combined drug release; drug delivery; imaging and
  hyperthermia