title: Radiologic Improvement After Early Medical Intervention in Localised Facial Morphea.
abstract: We report the case of a young girl who presented with hemiparesis, seizures, and subtle features consistent with a linear form of facial morphea (en coup de sabre). She was treated with pulsed parenteral steroids and oral steroids and started on methotrexate. Magnetic resonance imaging results and neurologic problems improved after 6 months. Switching off inflammation early in the course of disease seemed to reverse some of the central nervous system changes. Assessment of children with unexplained hemiparesis and seizures should include careful examination of the face and scalp, looking for subtle signs of skin change and asymmetry. This is one of the few reported cases of neuroradiologic improvement after immunosuppressive treatment in a child with en coup de sabre.
authors: Paediatric Dermatology, Great Ormond Street Hospital, London, UK.
authors: Muhammad Amjad
authors: MA
authors: Khan
authors: Paediatric Dermatology, Great Ormond Street Hospital, London, UK.
authors: Lindsay
authors: L
authors: Shaw
authors: Paediatric Rheumatology, Great Ormond Street Hospital, London, UK.
authors: Despina
authors: D
authors: Eleftheriou
authors: Paediatric Neurology, Great Ormond Street Hospital, London, UK.
authors: Prab
authors: P
authors: Prabhakar
authors: Paediatric Neuro-Radiology, Great Ormond Street Hospital, London, UK.
authors: Wui K
authors: WK
authors: Chong
authors: Paediatric Dermatology, Great Ormond Street Hospital, London, UK.
authors: Mary
authors: M
authors: Glover
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D003241:Consanguinity; D061345:Early Medical Intervention; D005145:Face / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000627:therapeutic use*; D012594:Scleroderma, Localized / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D008727:Methotrexate