title: Chemical modification of nucleic acids as a key technology for the development of RNA-based therapeutics.
abstract: RNA-based effector molecules (nucleic acid effectors) are important tools in molecular medicine because they offer a strategy to address therapeutically interesting targets that are not "druggable" with classic small molecule inhibitors. However, for in vivo applications, RNA-based effectors require specific chemical modifications to improve their stability and pharmacokinetic properties, as well as to minimize toxic and unspecific off-target effects.
authors: A
authors: A
authors: Grünweller
authors: R K
authors: RK
authors: Hartmann
mesh_terms: D006801:Humans; D009696:Nucleic Acids / Q000737:chemistry*; D012313:RNA / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D009696:Nucleic Acids; D012313:RNA