title: Managing the child with a diagnosis of Moebius syndrome: more than meets the eye.
abstract: Moebius syndrome (MBS) is a congenital, non-progressive facial and abducens nerve palsy in the presence of full vertical gaze and may be associated with limb abnormalities and craniofacial dysmorphisms. MBS is now defined as a disorder of rhombencephalic maldevelopment and recent gene discoveries have shown this to be a dominant disorder in a subset of patients. Accurate diagnosis and management by a multidisciplinary team with expertise in congenital facial palsy is paramount.
authors: Department of Clinical Genetics, Cheshire and Merseyside Regional Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Liverpool, UK.
authors: Victoria H
authors: VH
authors: McKay
authors: Regional Paediatric Burns and Plastic Surgery Service, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
authors: Leila L
authors: LL
authors: Touil
authors: Clinical and Molecular Genetics Units, UCL Institute of Child Health, London, UK.
authors: Dagan
authors: D
authors: Jenkins
authors: Regional Paediatric Burns and Plastic Surgery Service, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
authors: Adel Y
authors: AY
authors: Fattah
mesh_terms: D002648:Child; D002658:Developmental Disabilities / Q000209:etiology; D003937:Diagnosis, Differential; D020022:Genetic Predisposition to Disease; D006801:Humans; D020331:Mobius Syndrome / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D015835:Ocular Motility Disorders / Q000209:etiology
keywords: Moebius syndrome; Möbius sequence; management; minimum diagnostic criteria; rhombencephalic maldevelopment