title: [THE ROLE OF SYSTEM QUORUM SENSING UNDER CHRONIC UROGENITAL CHLAMYDIA INFECTION].
abstract: It is established that system quorum sensing (QS) assure social behavior of bacteria in regulation of genes of virulence and generalization of inflectional inflammatory process under chronic urogenital chlamydia infection. The techniques of gas chromatography and mass-spectrometry were applied to detect molecular markers of generalization of infectious process under urogenital chlamydiasis--activators of QS microbes (lactones, quinolones, furan ethers). The developed diagnostic gas chromatography and mass-spectrometry criteria of indexation of molecular markers under chronic urogenital chlamydia infection have high level of diagnostic sensitivity, specificity and prognostic value of positive and negative result. The application of techniques of gas chromatography and mass-spectrometry permits enhancing effectiveness of diagnostic of chronic inflectional inflammatory diseases of urogenital system of chlamydia etiology with identification of prognostic criteria of generalization of infectious process and subsequent prescription of timely and appropriate therapy
mesh_terms: D002689:Chlamydia / Q000302:isolation & purification / Q000502:physiology*; D002690:Chlamydia Infections / Q000097:blood / Q000382:microbiology*; D005260:Female; D005663:Furans / Q000097:blood; D006801:Humans; D007783:Lactones / Q000097:blood; D008297:Male; D011804:Quinolines / Q000097:blood; D053038:Quorum Sensing; D060737:Reproductive Tract Infections / Q000097:blood / Q000382:microbiology*; D014552:Urinary Tract Infections / Q000097:blood / Q000382:microbiology*
chemical_list: D005663:Furans; D007783:Lactones; D011804:Quinolines