title: Oral Delivery of Tumor-Targeting Salmonella to Treat Cancer in Mice.
abstract: Tumor-targeting bacteria have been developed as novel anticancer agents recently. To achieve their therapeutic effects, bacteria have conventionally been injected intravenously or intraperitoneally into animals or humans. Here, we describe the oral delivery of tumor-targeting Salmonella for cancer therapy in a mouse tumor model. We detail the experimental procedures for establishing a mouse tumor model, preparing bacterial culture, mouse gavage, and detection of the tumor-targeting capability of bacteria administered orally. We also discuss technical notes and provide practical advice that will help the users of this oral delivery model.
authors: Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, China. weidongping2001@hotmail.com.|Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. weidongping2001@hotmail.com.
authors: Dongping
authors: D
authors: Wei
authors: Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, China. ljjia@fudan.edu.cn.
authors: Lijun
authors: L
authors: Jia
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D012486:Salmonella typhimurium / Q000502:physiology*; D023041:Xenograft Model Antitumor Assays
keywords: Cancer therapy; Oral delivery; Salmonella; Solid tumor; Tumor-targeting bacteria