title: STENTYS Self-Apposing sirolimus-eluting stent in ST-segment elevation myocardial infarction: results from the randomised APPOSITION IV trial.
abstract: OBJECTIVE
  We sought to investigate the impact of the self-apposing, sirolimus-eluting STENTYS stent on midterm and long-term stent apposition and strut coverage compared with a zotarolimus-eluting balloon-expandable stent in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI).
  
  
  RESULTS
  In the APPOSITION IV trial, 152 STEMI patients were randomised (3:2) to the self-apposing, sirolimus-eluting STENTYS stent or a commercially available zotarolimus-eluting balloon-expandable stent at 12 sites in five countries with angiographic follow-up and optical coherence tomography at four or nine months. At four months, a lower percentage of malapposed stent struts was observed in the STENTYS group (N=21; Nstruts=501) compared with controls (N=26; Nstruts=326; 0.07% vs. 1.16%; p=0.002) with significantly more covered struts, using a 20 µm cut-off (94.32% vs. 89.09%; p=0.003). At nine months, the primary endpoint (percentage malapposed stent struts) was similar in both groups (STENTYS, N=40; Nstruts=566; control, N=21; Nstruts=292), showing complete apposition (p=0.55) and near total (>96%) coverage (p=0.58).
  
  
  CONCLUSIONS
  In STEMI patients undergoing PPCI, the self-apposing, sirolimus-eluting STENTYS stent was equivalent to a conventional drug-eluting balloon-expandable stent with respect to late stent strut apposition and coverage at nine months. However, stent strut apposition and coverage at four months were significantly better in the STENTYS group.
authors: Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Robert-Jan M
authors: RJ
authors: van Geuns
authors: Tuncay
authors: T
authors: Yetgin
authors: Alessio
authors: A
authors: La Manna
authors: Corrado
authors: C
authors: Tamburino
authors: Géraud
authors: G
authors: Souteyrand
authors: Pascal
authors: P
authors: Motreff
authors: Karel T
authors: KT
authors: Koch
authors: Mathias
authors: M
authors: Vrolix
authors: Alexander
authors: A
authors: IJsselmuiden
authors: Giovanni
authors: G
authors: Amoroso
authors: Jacques
authors: J
authors: Berland
authors: Gilles
authors: G
authors: Montalescot
authors: Emmanuel
authors: E
authors: Teiger
authors: Evald H
authors: EH
authors: Christiansen
authors: René
authors: R
authors: Spaargaren
authors: William
authors: W
authors: Wijns
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D017023:Coronary Angiography / Q000379:methods; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000601:surgery; D062645:Percutaneous Coronary Intervention / Q000379:methods; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: C489443:zotarolimus; D020123:Sirolimus