title: Prenatal prediction of neonatal death in single ventricle congenital heart disease.
abstract: OBJECTIVE
  The objective of this study was to determine whether prenatal ultrasound findings and cord blood N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and cardiac troponin T (cTnT) can predict neonatal mortality in single ventricle congenital heart disease.
  
  
  METHODS
  The association between neonatal mortality and prenatal ultrasound findings/cord blood biomarkers was evaluated in neonates delivered with a diagnosis of single ventricle congenital heart disease. The presence of prenatal ultrasound findings suggesting systemic outflow obstruction (ascending aorta < 2.5 percentile) or ventricular dysfunction (the presence of cardiomegaly or hydrops) was evaluated, and the total number of abnormal findings was converted to a numeric score called the 'single ventricle score'. In addition, NT pro-BNP and cTnT were measured in cord blood taken at the time of delivery.
  
  
  RESULTS
  A total of 48 cases of single ventricle congenital heart disease were included. The rate of neonatal mortality was 31% (15/48). The presence of either abnormal ultrasound findings (single ventricle score ≥ 2) or elevated concentrations of NT pro-BNP or cTnT was associated with increased risk of neonatal death.
  
  
  CONCLUSIONS
  The presence of either abnormal prenatal ultrasound findings or increased cord blood NT pro-BNP and cTnT concentrations was associated with the risk of neonatal death in single ventricle congenital heart disease.
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.|Department of Obstetrics and Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
authors: Seung Mi
authors: SM
authors: Lee
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors: Jeong Eun
authors: JE
authors: Kwon
authors: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: Sang Hoon
authors: SH
authors: Song
authors: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
authors: Gi Beom
authors: GB
authors: Kim
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors: Jung Yeon
authors: JY
authors: Park
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.|Department of Obstetrics and Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
authors: Byoung Jae
authors: BJ
authors: Kim
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors: Joon Ho
authors: JH
authors: Lee
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors: Chan-Wook
authors: CW
authors: Park
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors: Joong Shin
authors: JS
authors: Park
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors: Jong Kwan
authors: JK
authors: Jun
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003661:Decision Support Techniques; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005500:Follow-Up Studies; D006305:Health Status Indicators; D006330:Heart Defects, Congenital / Q000097:blood / Q000000981:diagnostic imaging / Q000401:mortality*; D006352:Heart Ventricles / Q000002:abnormalities*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D020107:Troponin T / Q000097:blood*; D016216:Ultrasonography, Prenatal
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain