title: Hospitalization for Pneumonia is Associated With Decreased 1-Year Survival in Patients With Type 2 Diabetes: Results From a Prospective Cohort Study.
abstract: Diabetes mellitus is a frequent comorbid conditions among patients with pneumonia living in the community.The aim of our study is to evaluate the impact of hospitalization for pneumonia on early (30 day) and late mortality (1 year) in patients with type 2 diabetes mellitus.Prospective comparative cohort study of 203 patients with type 2 diabetes hospitalized for pneumonia versus 206 patients with diabetes hospitalized for other noninfectious causes from January 2012 to December 2013 at Policlinico Umberto I (Rome). Enrolled patients were followed up to discharge and up to 1 year after initial hospital admission or death.Overall, 203 patients with type 2 diabetes admitted to hospital for pneumonia were compared to 206 patients with type 2 diabetes admitted for other causes (39.3% decompensated diabetes, 21.4% cerebrovascular diseases, 9.2% renal failure, 8.3% acute myocardial infarction, and 21.8% other causes). Compared to control patients, those admitted for pneumonia showed a higher 30-day (10.8% vs 1%, P < 0.001) and 1-year mortality rate (30.3% vs 16.8%, P < 0.001). Compared to survivors, nonsurvivor patients with pneumonia had a higher incidence of moderate to severe chronic kidney disease, hemodialysis, and malnutrition were more likely to present with a mental status deterioration, and had a higher number of cardiovascular events during the follow-up period. Cox regression analysis found age, Charlson comorbidity index, pH < 7.35 at admission, hemodialysis, and hospitalization for pneumonia as variables independently associated with mortality.Hospitalization for pneumonia is associated with decreased 1-year survival in patients with type 2 diabetes, and appears to be a major determinant of long-term outcome in these patients.
authors: From the Department of Public Health and Infectious Diseases (FM, RA, PP, FA, VV, VM); Department of Internal Medicine and Medical Specialties (TG, CR, VF); Faculty of Medicine (GL, ME); Department of Emergency Medicine (BG); and Department of Clinical Medicine, "Sapienza" University of Rome, Rome, Italy (TG).
authors: Marco
authors: M
authors: Falcone
authors: Giusy
authors: G
authors: Tiseo
authors: Alessandro
authors: A
authors: Russo
authors: Laura
authors: L
authors: Giordo
authors: Elisa
authors: E
authors: Manzini
authors: Giuliano
authors: G
authors: Bertazzoni
authors: Paolo
authors: P
authors: Palange
authors: Gloria
authors: G
authors: Taliani
authors: Roberto
authors: R
authors: Cangemi
authors: Alessio
authors: A
authors: Farcomeni
authors: Vincenzo
authors: V
authors: Vullo
authors: Francesco
authors: F
authors: Violi
authors: Mario
authors: M
authors: Venditti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000401:mortality*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D011014:Pneumonia / Q000150:complications*; D011446:Prospective Studies