title: Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis.
abstract: Scalp psoriasis shows a variable clinical spectrum and in many cases poses a great therapeutic challenge. However, it remains unknown whether the immune response of scalp psoriasis differs from understood pathomechanisms of psoriasis in other skin areas. We sought to determine the cellular and molecular phenotype of scalp psoriasis by performing a comparative analysis of scalp and skin using lesional and nonlesional samples from 20 Caucasian subjects with untreated moderate to severe psoriasis and significant scalp involvement and 10 control subjects without psoriasis. Our results suggest that even in the scalp, psoriasis is a disease of the inter-follicular skin. The immune mechanisms that mediate scalp psoriasis were found to be similar to those involved in skin psoriasis. However, the magnitude of dysregulation, number of differentially expressed genes, and enrichment of the psoriatic genomic fingerprint were more prominent in skin lesions. Furthermore, the scalp transcriptome showed increased modulation of several gene-sets, particularly those induced by interferon-gamma, compared with that of skin psoriasis, which was mainly associated with activation of TNFα/L-17/IL-22-induced keratinocyte response genes. We also detected differences in expression of gene-sets involving negative regulation, epigenetic regulation, epidermal differentiation, and dendritic cell or Th1/Th17/Th22-related T-cell processes.
authors: Department of Dermatology, Reina Sofia University Hospital, Cordoba, Spain.|Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC)/Hospital Universitario Reina Sofia/Universidad de Cordoba, Cordoba, Spain.
authors: Juan
authors: J
authors: Ruano
authors: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.|Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.|Department of Genetics and Genomics Science, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.|Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America.
authors: Mayte
authors: M
authors: Suárez-Fariñas
authors: Department of Dermatology, Tel-Hashomer Hospital and Tel-Aviv University, Tel-Aviv, Israel.
authors: Avner
authors: A
authors: Shemer
authors: Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
authors: Margeaux
authors: M
authors: Oliva
authors: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.|Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America.
authors: Emma
authors: E
authors: Guttman-Yassky
authors: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America.
authors: James G
authors: JG
authors: Krueger
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D003713:Dendritic Cells / Q000473:pathology; D044127:Epigenesis, Genetic; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000235:genetics* / Q000473:pathology*; D012535:Scalp / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology; D018417:Th1 Cells / Q000378:metabolism; D058504:Th17 Cells / Q000378:metabolism; D059467:Transcriptome
chemical_list: D016207:Cytokines