title: Cross-talk between circadian clocks, sleep-wake cycles, and metabolic networks: Dispelling the darkness.
abstract: Integration of knowledge concerning circadian rhythms, metabolic networks, and sleep-wake cycles is imperative for unraveling the mysteries of biological cycles and their underlying mechanisms. During the last decade, enormous progress in circadian biology research has provided a plethora of new insights into the molecular architecture of circadian clocks. However, the recent identification of autonomous redox oscillations in cells has expanded our view of the clockwork beyond conventional transcription/translation feedback loop models, which have been dominant since the first circadian period mutants were identified in fruit fly. Consequently, non-transcriptional timekeeping mechanisms have been proposed, and the antioxidant peroxiredoxin proteins have been identified as conserved markers for 24-hour rhythms. Here, we review recent advances in our understanding of interdependencies amongst circadian rhythms, sleep homeostasis, redox cycles, and other cellular metabolic networks. We speculate that systems-level investigations implementing integrated multi-omics approaches could provide novel mechanistic insights into the connectivity between daily cycles and metabolic systems.
authors: Department of Clinical Neurosciences, University of Cambridge Metabolic Research Laboratories, National Institutes of Health Biomedical Research Centre, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
authors: Sandipan
authors: S
authors: Ray
authors: Department of Clinical Neurosciences, University of Cambridge Metabolic Research Laboratories, National Institutes of Health Biomedical Research Centre, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
authors: Akhilesh B
authors: AB
authors: Reddy
mesh_terms: D000818:Animals; D056926:CLOCK Proteins / Q000378:metabolism; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D004331:Drosophila melanogaster / Q000502:physiology; D025461:Feedback, Physiological / Q000502:physiology*; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000502:physiology; D010084:Oxidation-Reduction; D054464:Peroxiredoxins / Q000378:metabolism; D017440:Photoperiod; D015398:Signal Transduction; D037761:Sirtuins / Q000378:metabolism; D012890:Sleep / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000502:physiology; D049490:Systems Biology; D014851:Wakefulness / Q000502:physiology*
chemical_list: D054464:Peroxiredoxins; D056926:CLOCK Proteins; D037761:Sirtuins
keywords: circadian rhythms; metabolic networks; non-transcriptional oscillator; peroxiredoxin; redox regulation; sleep-wake cycle; systems biology