title: Risk Factors for Silent Lacunar Infarction in Patients with Transient Ischemic Attack.
abstract: BACKGROUND Lacunar infarctions represent 25% of ischemic strokes. Lacunar stroke and transient ischemic attack (TIA) share a number of symptoms. This study aimed to assess the potential risk factors for lacunar infarction in patients with TIA. MATERIAL AND METHODS This was a retrospective study performed at the Beijing Military General Hospital in patients with TIA admitted between March 2010 and December 2011. Patients were grouped according to lacunar vs. no lacunar infarction. All patients were diagnosed using diffusion-weighted imaging (DWI) on brain magnetic resonance imaging (MRI). Brain angiography (computed tomography and MRI) was used to measure intracranial stenosis. Carotid artery stenosis was measured by ultrasound. RESULTS Patients with TIA and lacunar infarction (n=298) were older than those without lacunar infarction (n=157) (69.4±10.0 vs. 58.9±9.0 years, P<0.001) and showed a higher frequency of males (51.7% vs. 41.4%, P=0.037), hypertension (75.3% vs. 45.9%, P<0.001), diabetes (32.6% vs. 21.0%, P=0.010), hyperlipidemia (53.4% vs. 29.3%, P<0.001), carotid stenosis (73.2% vs. 40.1%, P<0.001), and intracranial stenosis (55.6% vs. 31.9%, P<0.001), but a lower frequency of alcohol drinking (8.1% vs. 14.0%, P=0.045). Lacunar infarction mostly involved the anterior circulation (62.8%). Multivariate analysis showed that age (odds ratio (OR)=1.085, 95% confidence interval (95%CI): 1.054-1.117, P<0.001), hypertension (OR=1.738, 95%CI: 1.041-2.903, P=0.035), hyperlipidemia (OR=2.169, 95%CI: 1.307-3.601, P=0.003), and carotid stenosis (OR=1.878, 95%CI: 1.099-3.206, P=0.021) were independently associated with lacunar infarction. CONCLUSIONS Age, hypertension, hyperlipidemia, and carotid stenosis were independently associated with silent lacunar infarction in patients with TIA.
authors: Postgraduate School, The Third Millitary Medical University, Chongqing, China (mainland).
authors: Ying
authors: Y
authors: Li
authors: Postgraduate School, Third Military Medical University, Chongqing, China (mainland).
authors: Nan
authors: N
authors: Liu
authors: Department of Neurology, Beijing Military General Hospital, Beijing, China (mainland).
authors: Yonghua
authors: Y
authors: Huang
authors: Department of Neurology, Beijing Military General Hospital, Beijing, China (mainland).
authors: Wei
authors: W
authors: Wei
authors: Department of Neurology, Beijing Military 254 Hospital, Tianjin, China (mainland).
authors: Fei
authors: F
authors: Chen
authors: Department of Neurology, Beijing Military General Hospital, Beijing, China (mainland).
authors: Weiwei
authors: W
authors: Zhang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016893:Carotid Stenosis / Q000150:complications; D002533:Cerebral Angiography; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D002546:Ischemic Attack, Transient / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D059409:Stroke, Lacunar / Q000209:etiology*