title: Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis.
abstract: Palmoplantar pustulosis (PPP) is a chronic pustular dermatitis of the palms and soles, which is frequently associated with significant pruritus and pain, often limiting daily activities. We present the case of a 36-year-old man with severe PPP who had treatment failure with multiple medical therapies but showed marked improvement with high-dose rate brachytherapy. Brachytherapy has the advantage of providing a conformal dose distribution over complex curved surfaces, such as the foot and ankle. Our observations suggest that brachytherapy may be a well-tolerated treatment option for patients with severe, refractory PPP.
authors: Harvard-MIT Health Sciences and Technology (HST), Harvard Medical School, Boston, MA, USA.
authors: D
authors: D
authors: Timerman
authors: Department of Radiation Oncology, Division of Brachytherapy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: P M
authors: PM
authors: Devlin
authors: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: V E
authors: VE
authors: Nambudiri
authors: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: N A
authors: NA
authors: Wright
authors: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: R A
authors: RA
authors: Vleugels
authors: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: R A
authors: RA
authors: Clark
authors: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: T S
authors: TS
authors: Kupper
authors: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.|Department of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: J F
authors: JF
authors: Merola
authors: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: M
authors: M
authors: Patel
mesh_terms: D000328:Adult; D001918:Brachytherapy / Q000379:methods*; D005533:Foot Dermatoses / Q000532:radiotherapy*; D006229:Hand Dermatoses / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000532:radiotherapy*; D016896:Treatment Outcome