title: Intestinal Tumor Development in C57BL/6J-ApcMin/+ Mice Expressing Human Sulphotransferases 1A1 and 1A2 After Oral Exposure to 2,5-Dimethylfuran.
abstract: BACKGROUND
  2,5-dimethylfuran (DMF) is formed during heating of foods. Following side chain hydroxylation, DMF could be a substrate for human sulphotransferases (SULTs), which may lead to formation of a DNA reactive electrophile. Only few conflicting in vitro and no in vivo studies on DMF currently exist.
  
  
  METHODS
  The tumorigenic potential of DMF was studied in multiple intestinal neoplasia Apc(Min/+) (Min) mice that are sensitive to intestinal carcinogenesis and express hSULTs 1A1 and 1A2 (Min/hSULT). Min and Min/hSULT mice were orally exposed to DMF for six weeks.
  
  
  RESULTS
  The intestinal tumor development of untreated female Min/hSULT mice was significantly lower compared to that of untreated Min females. No such effects of hSULTs were seen in males. DMF had a weak tumorigenic potential in the colon of female Min/hSULT mice, but not in males. Tumor development in Min mice was not affected.
  
  
  CONCLUSIONS
  Overall, the tumorigenic potential of DMF in a metabolically competent mouse model was not convincing.
authors: Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway.
authors: Anja Hortemo
authors: AH
authors: Høie
authors: Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway.
authors: Camilla
authors: C
authors: Svendsen
authors: Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway.
authors: Tone
authors: T
authors: Rasmussen
authors: Office of the Director-General, Norwegian Institute of Public Health, Oslo, Norway.
authors: Jan
authors: J
authors: Alexander
authors: Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway trine.husoy@fhi.no.
authors: Trine
authors: T
authors: Husøy
mesh_terms: D058739:Aberrant Crypt Foci / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D000284:Administration, Oral; D000818:Animals; D015239:Arylsulfotransferase / Q000235:genetics / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D063646:Carcinogenesis / Q000187:drug effects / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D005663:Furans / Q000008:administration & dosage / Q000633:toxicity*; D017491:Genes, APC / Q000502:physiology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D005663:Furans; C037555:2,5-dimethylfuran; D015239:Arylsulfotransferase; C513291:Sult1a1 protein, mouse; C513288:Sult1c1 protein, mouse
keywords: 2,5-Dimethylfuran; Min mice; SULT; human sulphotransferases; tumorigenicity