title: Human innate lymphoid cells.
abstract: The interest in innate lymphoid cells (ILC) has rapidly grown during the last decade. ILC include distinct cell types that are collectively involved in host protection against pathogens and tumor cells and in the regulation of tissue homeostasis. Studies in mice enabled a broad characterization of ILC function and of their developmental requirements. In humans all mature ILC subsets have been characterized and their role in the pathogenesis of certain disease is emerging. Nonetheless, still limited information is available on human ILC development. Indeed, only the cell precursors committed toward NK cells or ILC3 have been described. Here, we review the most recent finding on human mature ILC, discussing their tissue localization and function. Moreover, we summarize the available data regarding human ILC development.
authors: U.O.C. Clinical and Experimental Immunology, IRCCS Giannina Gaslini Institute, Genova, Italy.
authors: Elisa
authors: E
authors: Montaldo
authors: Department of Experimental Medicine, University of Genova, Genova, Italy.
authors: Paola
authors: P
authors: Vacca
authors: Department of Experimental Medicine, University of Genova, Genova, Italy; U.O. Immunology IRCCS AOU San Martino-IST, Genova, Italy.
authors: Chiara
authors: C
authors: Vitale
authors: Department of Medicine, University of Verona, Verona, Italy; Ospedale Sacro Cuore Negrar, Verona, Italy.
authors: Francesca
authors: F
authors: Moretta
authors: Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy; Department of Pediatrics, University of Pavia, Pavia, Italy.
authors: Franco
authors: F
authors: Locatelli
authors: Department of Experimental Medicine, University of Genova, Genova, Italy; U.O. Immunology IRCCS AOU San Martino-IST, Genova, Italy. Electronic address: mariacristina.mingari@unige.it.
authors: Maria Cristina
authors: MC
authors: Mingari
authors: Department of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
authors: Lorenzo
authors: L
authors: Moretta
mesh_terms: D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D009928:Organ Specificity; D010641:Phenotype; D054504:Precursor Cells, T-Lymphoid / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015415:Biomarkers
keywords: HSCT; ILC; ILC development; NK cell differentiation; NK cells