title: Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study.
abstract: Short self-reported sleep duration is associated with dietary intake and this association may partly mediate the link between short sleep and metabolic abnormalities. Subjective sleep measures, however, may be inaccurate and biased. The objective of this study was to evaluate the associations between actigraphic measures of sleep fragmentation, efficiency and duration and energy and macronutrient intakes. We used data from a subgroup of 439 participants of the population-based cohort, Rotterdam Study. Sleep was assessed using 7-day actigraphy and sleep diaries, and dietary data with a validated food frequency questionnaire. We assessed the associations of actigraphic sleep parameters with dietary intake using multivariable linear regression models. Higher sleep fragmentation was associated with 4.19 g lower carbohydrate intake per standard deviation of fragmentation {β [95% confidence interval (CI) = -4.19 (-8.0, -0.3)]; P = 0.03}. Each additional percentage increase in sleep efficiency was associated with 11.1 kcal lower energy intake [β (95% CI) = -11.1 (-20.6, -1.7); P = 0.02]. Furthermore, very short sleep duration (<5.5 h) was associated with 218.1 kcal higher energy intake [β (95% CI = 218.06 (33.3, 402.8), P = 0.02], relative to the reference group (≥6.5 to <7.5 h). We observed associations between higher sleep fragmentation with lower carbohydrate intake, and both lower sleep efficiency and very short sleep duration (<5 h) with higher energy intake. The association between sleep and higher energy intake could mediate, in part, the link between short sleep or sleep fragmentation index and metabolic abnormalities.
authors: Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.|Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
authors: Hassan S
authors: 0000-0002-1650-679X
authors: HS
authors: Dashti
authors: Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
authors: Lisette A
authors: LA
authors: Zuurbier
authors: Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.|Department of Internal Medicine, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
authors: Ester
authors: E
authors: de Jonge
authors: Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
authors: Trudy
authors: T
authors: Voortman
authors: Nutritional Epidemiology Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors: Paul F
authors: PF
authors: Jacques
authors: Cardiovascular Nutrition Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors: Stefania
authors: S
authors: Lamon-Fava
authors: Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.|Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
authors: Frank A J L
authors: FA
authors: Scheer
authors: Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.|Global Public Health, Leiden University College, The Hague, the Netherlands.
authors: Jessica C
authors: JC
authors: Kiefte-De Jong
authors: Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
authors: Albert
authors: A
authors: Hofman
authors: Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.|Department of Epidemiology, Centro Nacional Investigaciones Cardiovasculares (CNIC), Madrid, Spain.|Instituto Madrileño de Estudios Avanzados en Alimentación (IMDEA-FOOD), Madrid, Spain.
authors: José M
authors: JM
authors: Ordovás
authors: Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
authors: Oscar H
authors: OH
authors: Franco
authors: Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.|Department of Psychiatry, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
authors: Henning
authors: H
authors: Tiemeier
mesh_terms: D056044:Actigraphy; D000368:Aged; D004032:Diet; D002149:Energy Intake; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D057566:Self Report; D012890:Sleep; D012892:Sleep Deprivation / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D013997:Time Factors
keywords: dietary intake; epidemiology; macronutrients; sleep duration