title: Metamizole: an effective solution for vasospasm.
abstract: OBJECTIVE
  Vasospasm is a major problem during microsurgery, and a variety of pharmacological agents are used to alleviate vasospasm. This study aimed to demonstrate the effect of metamizole on vasospasm and to compare it with lidocaine and papaverine, both of which are commonly used to correct vasospasm.
  
  
  METHODS
  Thirty-five female rats were randomly divided into four groups: Group 1, 2, 3, and 4, which were the control (n = 8), metamizole (n = 9), papaverine (n = 9), and lidocaine (n = 9) treatment groups, respectively. Both femoral arteries of all of the rats were dissected, and they were immediately photographed. The pharmacological agents or saline in the control group were topically applied to the arteries, accordingly. The arteries were photographed again at time points 5, 10, 20 and 30 minutes after application of the agents. The images were transferred to a computer and the arteries' diameters were measured in mm.
  
  
  RESULTS
  All of the pharmacological treatments increased the diameter of the arteries significantly during the observation period. However, comparison between the groups indicated that metamizole and papaverine produced significantly more vasodilation than the lidocaine group, for all time points measured after application.
  
  
  CONCLUSIONS
  These findings show that topically applied metamizole is as effective as papaverine at alleviating vasospasm during the 30 minutes time interval. This administration may be considered as a good alternative to correct vasospasm during microsurgery.
authors: a Department of Plastic, Reconstructive and Aesthetic Surgery , Ankara University Faculty of Medicine , Ankara , Turkey and.
authors: Burak
authors: B
authors: Kaya
authors: a Department of Plastic, Reconstructive and Aesthetic Surgery , Ankara University Faculty of Medicine , Ankara , Turkey and.
authors: Servet
authors: S
authors: Elçin Işılgan
authors: a Department of Plastic, Reconstructive and Aesthetic Surgery , Ankara University Faculty of Medicine , Ankara , Turkey and.
authors: Savaş
authors: S
authors: Serel
authors: b Department of Medical Pharmacology , Ankara University Faculty of Medicine , Ankara , Turkey.
authors: Hakan
authors: H
authors: Ergün
mesh_terms: D000287:Administration, Topical; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D004177:Dipyrone / Q000494:pharmacology*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D007091:Image Processing, Computer-Assisted; D008012:Lidocaine / Q000494:pharmacology; D023421:Models, Animal; D010208:Papaverine / Q000494:pharmacology; D011897:Random Allocation; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D014665:Vasodilator Agents; D004177:Dipyrone; D008012:Lidocaine; D010208:Papaverine
keywords: Metamizole; lidocaine; microsurgery; papaverine; vasodilation; vasospasm