title: Biomaterial-Stabilized Soft Tissue Healing for Healing of Critical-Sized Bone Defects: the Masquelet Technique.
abstract: Critical-sized bone defects present a significant burden to the medical community due to their challenging treatment. However, a successful limb-salvaging technique, the Masquelet Technique (MT), has significantly improved the prognosis of many segmental bone defects in helping to restore form and function. Although the Masquelet Technique has proven to be clinically effective, the physiology of the healing it induces is not well understood. Multiple modifiable factors have been implicated by various surgical and research teams, but no single factor has been proven to be critical to the success of the Masquelet Technique. In this review the most recent clinical and experimental evidence that supports and helps to decipher the traditional Masquelet, as well as the modifiable factors and their effect on the success of the technique are discussed. In addition, future developments for the integration of the traditional Masquelet Technique with the use of alternative biomaterials to increase the effectiveness and expand the clinical applicability of the Masquelet Technique are reviewed.
authors: Division of Orthopaedic Surgery, McGill University Health Centre, Montreal, H3g 1A4, Quebec, Canada.
authors: Magdalena
authors: M
authors: Tarchala
authors: Division of Orthopaedic Surgery, McGill University Health Centre, Montreal, H3g 1A4, Quebec, Canada.
authors: Edward J
authors: EJ
authors: Harvey
authors: Faculty of Dentistry, McGill University, Montreal, H3A 0G4, Quebec, Canada.
authors: Jake
authors: J
authors: Barralet
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D050723:Fractures, Bone / Q000628:therapy; D019344:Lactic Acid / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D019904:Polymethyl Methacrylate / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D019904:Polymethyl Methacrylate
keywords: biopolymer; critical-sized bone defect; fibrous capsule; guided bone regeneration; pmma