title: Coronary anatomy as related to bicuspid aortic valve morphology.
abstract: Variable coronary anatomy has been described in patients with bicuspid aortic valves (BAVs). This was never specified to BAV morphology, and prognostic relevance of coronary vessel dominance in this patient group is unclear. The purpose of this study was to evaluate valve morphology in relation to coronary artery anatomy and outcome in patients with isolated BAV and with associated aortic coarctation (CoA).
  
  
  
  Coronary anatomy was evaluated in 186 patients with BAV (141 men (79%), 51±14 years) by CT and invasive coronary angiography. Correlation of coronary anatomy was made with BAV morphology and coronary events.
  
  
  
  Strictly bicuspid valves (without raphe) with left-right cusp fusion (type 1B) had more left dominant coronary systems compared with BAVs with left-right cusp fusion with a raphe (type 1A) (48% vs. 26%, p=0.047) and showed more separate ostia (28% vs. 9%, p=0.016). Type 1B BAVs had more coronary artery disease than patients with type 1A BAV (36% vs. 19%, p=0.047). More left dominance was seen in BAV patients with CoA than in patients without (65% vs. 24%, p<0.05).
  
  
  
  The incidence of a left dominant coronary artery system and separate ostia was significantly related to BAVs with left-right fusion without a raphe (type 1B). These patients more often had significant coronary artery disease. In patients with BAV and CoA, left dominancy is more common.
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Wilke M C
authors: WM
authors: Koenraadt
authors: Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
authors: George
authors: G
authors: Tokmaji
authors: Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Marco C
authors: MC
authors: DeRuiter
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Hubert W
authors: HW
authors: Vliegen
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Arthur J H A
authors: AJ
authors: Scholte
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Hans Marc J
authors: HM
authors: Siebelink
authors: Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Adriana C
authors: AC
authors: Gittenberger-de Groot
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Michiel A
authors: MA
authors: de Graaf
authors: Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.
authors: Ron
authors: R
authors: Wolterbeek
authors: Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
authors: Barbara J
authors: BJ
authors: Mulder
authors: Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
authors: Berto J
authors: BJ
authors: Bouma
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Martin J
authors: MJ
authors: Schalij
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Monique R M
authors: MR
authors: Jongbloed
mesh_terms: D000328:Adult; D000368:Aged; D001017:Aortic Coarctation / Q000000981:diagnostic imaging* / Q000453:epidemiology; D001021:Aortic Valve / Q000002:abnormalities* / Q000000981:diagnostic imaging; D000082882:Bicuspid Aortic Valve Disease; D000072226:Computed Tomography Angiography; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D004452:Echocardiography; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors