title: Decreased hepatic contents of coenzyme A molecular species in mice after subchronic mild social defeat stress.
abstract: Social stress may precipitate psychiatric disorders such as depression, which is related to the occurrence of the metabolic syndrome, including obesity and type 2 diabetes. We have evaluated the effects of social stress on central and peripheral metabolism using a model of depression in mice. In the present study, we focused on coenzyme A (CoA) molecular species [i.e. non-esterified CoA (CoASH), acetyl-CoA and malonyl-CoA] which play important roles in numerous metabolic pathways, and we analyzed changes in expression of these molecules in the hypothalamus and liver of adult male mice (C57BL/6J) subjected to 10 days of subchronic mild social defeat stress (sCSDS) with ICR mice as aggressors. Mice (n = 12) exposed to showed hyperphagia- and polydipsia-like symptoms and increased body weight gain compared with control mice which were not affected by exposure to ICR mice (n = 12). To elucidate the underlying metabolic features in the sCSDS model, acetyl-CoA, malonyl-CoA and CoASH tissue levels were analyzed using the acyl-CoA cycling method. The levels of hypothalamic malonyl-CoA, which decreases feeding behavior, were not influenced by sCSDS. However, sCSDS reduced levels of acetyl-CoA, malonyl-CoA and total CoA (sum of the three CoA molecular species) in the liver. Hence, hyperphagia-like symptoms in sCSDS mice evidently occurred independently of hypothalamic malonyl-CoA, but might consequently lead to down-regulation of hepatic CoA via altered expression of nudix hydrolase 7. Future studies should investigate the molecular mechanism(s) underlying the down-regulation of liver CoA pools in sCSDS mice.
authors: a College of Agriculture, Ibaraki University , Ami , Ibaraki , Japan .|b National Federation of Agricultural Cooperative Associations, Central Research Institute for Feed and Livestock, Swine Research Sec , Tsukuba , Ibaraki , Japan .
authors: Yoshifumi
authors: Y
authors: Kubota
authors: a College of Agriculture, Ibaraki University , Ami , Ibaraki , Japan .|c Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM) , Ami , Ibaraki , Japan , and.
authors: Tatsuhiko
authors: T
authors: Goto
authors: a College of Agriculture, Ibaraki University , Ami , Ibaraki , Japan .
authors: Yuki
authors: Y
authors: Hagiya
authors: a College of Agriculture, Ibaraki University , Ami , Ibaraki , Japan .|c Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM) , Ami , Ibaraki , Japan , and.|d United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology , Fuchu-City, Tokyo , Japan.
authors: Shigeru
authors: S
authors: Chohnan
authors: a College of Agriculture, Ibaraki University , Ami , Ibaraki , Japan .|c Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM) , Ami , Ibaraki , Japan , and.|d United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology , Fuchu-City, Tokyo , Japan.
authors: Atsushi
authors: A
authors: Toyoda
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000502:physiology; D003065:Coenzyme A / Q000378:metabolism*; D003863:Depression / Q000378:metabolism*; D004195:Disease Models, Animal; D015536:Down-Regulation; D007031:Hypothalamus / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008316:Malonyl Coenzyme A / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D013315:Stress, Psychological / Q000378:metabolism*; D015430:Weight Gain / Q000502:physiology
chemical_list: D008316:Malonyl Coenzyme A; D000105:Acetyl Coenzyme A; D003065:Coenzyme A
keywords: Coenzyme A; depression; hypothalamus; liver; mouse; social defeat stress