title: Filament assemblies in foreign nucleic acid sensors.
abstract: Helical filamentous assembly is ubiquitous in biology, but was only recently realized to be broadly employed in the innate immune system of vertebrates. Accumulating evidence suggests that the filamentous assemblies and helical oligomerization play important roles in detection of foreign nucleic acids and activation of the signaling pathways to produce antiviral and inflammatory mediators. In this review, we focus on the helical assemblies observed in the signaling pathways of RIG-I-like receptors (RLRs) and AIM2-like receptors (ALRs). We describe ligand-dependent oligomerization of receptor, receptor-dependent oligomerization of signaling adaptor molecules, and their functional implications and regulations.
authors: Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: jsohn@jhmi.edu.
authors: Jungsan
authors: J
authors: Sohn
authors: Harvard Medical School, Boston, MA, USA. Electronic address: Sun.Hur@childrens.harvard.edu.
authors: Sun
authors: S
authors: Hur
mesh_terms: D000818:Animals; D001704:Biopolymers / Q000737:chemistry; D015374:Biosensing Techniques; D008024:Ligands; D009696:Nucleic Acids / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D015398:Signal Transduction
chemical_list: D001704:Biopolymers; D008024:Ligands; D009696:Nucleic Acids; D011506:Proteins