title: Antiviral therapy of primary cytomegalovirus infection with vascular thrombosis in immunocompetent adults.
abstract: BACKGROUND
  Vascular thromboembolism (VTE) complicating cytomegalovirus (CMV) primary infection is increasingly reported in immunocompetent adults. No guideline is, however, currently available for the management of these infections and particularly for the antiviral therapy indication.
  
  
  METHODS
  We performed a literature review of VTE complicating CMV primary infection in immunocompetent adults using PubMed.
  
  
  RESULTS
  Sixty-nine case patients of VTE complicating CMV primary infection were reported. The main sites of venous thrombosis were the splanchnic veins (30 patients) or those of the lower limbs (18 patients). One-third of patients presented with pulmonary embolism (25 patients). Forty-nine patients (76%) had at least one VTE risk factor, inherited or acquired thrombophilia for 37 patients (58%), and another risk factor for 27 patients (42%). Only 11 patients received an antiviral therapy. A positive outcome was observed in all patients.
  
  
  CONCLUSIONS
  We suggest that antiviral therapy should be considered for patients presenting with severe VTE, VTE with a negative outcome despite anticoagulation, severe organ involvement, or for patients managed in the intensive care unit.
authors: Service de maladies infectieuses et tropicales, centre hospitalier universitaire de Lille, 2, avenue Oscar-Lambret, 59000 Lille, France; Service de maladies infectieuses et tropicales, centre hospitalier de Tourcoing, 155, rue du Président-Coty, 59200 Tourcoing, France. Electronic address: ldeconinck@ch-tourcoing.fr.
authors: L
authors: L
authors: Deconinck
authors: Service de maladies infectieuses et tropicales, hôpital militaire Bégin, 69, avenue de Paris, 94160 Saint-Mandé, France.
authors: C
authors: C
authors: Flateau
authors: Service de maladies infectieuses et tropicales, centre hospitalier universitaire de Lille, 2, avenue Oscar-Lambret, 59000 Lille, France; Service de médecine interne, centre hospitalier universitaire de Lille, 2, avenue Oscar-Lambret, 59000 Lille, France.
authors: M
authors: M
authors: Pichenot
authors: Service de médecine interne, centre hospitalier universitaire de Lille, 2, avenue Oscar-Lambret, 59000 Lille, France.
authors: S
authors: S
authors: Morell-Dubois
authors: Service de médecine interne, centre hospitalier universitaire de Lille, 2, avenue Oscar-Lambret, 59000 Lille, France.
authors: H
authors: H
authors: Maillard
authors: Service de médecine interne, centre hospitalier universitaire de Lille, 2, avenue Oscar-Lambret, 59000 Lille, France.
authors: P-Y
authors: PY
authors: Hatron
authors: Service de maladies infectieuses et tropicales, centre hospitalier universitaire de Lille, 2, avenue Oscar-Lambret, 59000 Lille, France.
authors: B
authors: B
authors: Guery
authors: Service de maladies infectieuses et tropicales, centre hospitalier universitaire de Lille, 2, avenue Oscar-Lambret, 59000 Lille, France.
authors: K
authors: K
authors: Faure
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D007121:Immunocompetence; D013927:Thrombosis / Q000821:virology*
chemical_list: D000998:Antiviral Agents
keywords: Antiviral therapy; Cytomegalovirus; Cytomégalovirus; Thrombose; Thrombosis; Traitement antiviral