title: Iatrogenic Subclinical Hyperthyroidism Does Not Promote Weight Loss.
abstract: OBJECTIVE
  Among patients who have undergone total thyroidectomy, do those with thyroid cancer being kept iatrogenically subclinical hyperthyroid (SCH) differ from euthyroid patients in long-term weight change?
  
  
  METHODS
  In a retrospective study, medical records identified 291 patients who had undergone a thyroidectomy for differentiated thyroid cancer or benign thyroid disease. Weight, thyroid-stimulating hormone, and levothyroxine dose were measured presurgery and 1, 2, and 3 years postsurgery.
  
  
  RESULTS
  Of 291 patients, 147 were in the SCH group and 144 were in the euthyroid group. At all 3 years both groups gained weight from baseline, but the two groups did not differ in weight change from baseline at any time period: year 1 (SCH mean 0.4% ± 6.2% weight gain vs euthyroid group mean 2.2% ± 6.6% weight gain; P = 0.12), year 2 (SCH mean 1.1% ± 9.1% weight gain vs euthyroid mean 2.9% ± 7.8% weight gain; P = 0.22), and year 3 (SCH mean 2.6% ± 9.2% weight gain vs euthyroid mean 3.1% ± 11.1% weight gain; P = 0.49).
  
  
  CONCLUSIONS
  Among total thyroidectomy patients, weight change did not differ between SCH patients and euthyroid patients at years 1 through 3. As such, the use of levothyroxine to induce SCH did not lead to long-term weight change when compared with euthyroid patients.
authors: From the Department of Internal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, and the Department of Internal Medicine, University of Nebraska Medical Center, Omaha.
authors: Rohit
authors: R
authors: Kedia
authors: From the Department of Internal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, and the Department of Internal Medicine, University of Nebraska Medical Center, Omaha.
authors: Alicia
authors: A
authors: Lowes
authors: From the Department of Internal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, and the Department of Internal Medicine, University of Nebraska Medical Center, Omaha.
authors: Sarah
authors: S
authors: Gillis
authors: From the Department of Internal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, and the Department of Internal Medicine, University of Nebraska Medical Center, Omaha.
authors: Ronald
authors: R
authors: Markert
authors: From the Department of Internal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, and the Department of Internal Medicine, University of Nebraska Medical Center, Omaha.
authors: Thomas
authors: T
authors: Koroscil
mesh_terms: D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000601:surgery; D013964:Thyroid Neoplasms / Q000601:surgery; D013965:Thyroidectomy / Q000009:adverse effects; D013974:Thyroxine / Q000627:therapeutic use; D015431:Weight Loss / Q000502:physiology*
chemical_list: D013974:Thyroxine