title: Prioritization of Susceptibility Genes for Ectopic Pregnancy by Gene Network Analysis.
abstract: Ectopic pregnancy is a very dangerous complication of pregnancy, affecting 1%-2% of all reported pregnancies. Due to ethical constraints on human biopsies and the lack of suitable animal models, there has been little success in identifying functionally important genes in the pathogenesis of ectopic pregnancy. In the present study, we developed a random walk-based computational method named TM-rank to prioritize ectopic pregnancy-related genes based on text mining data and gene network information. Using a defined threshold value, we identified five top-ranked genes: VEGFA (vascular endothelial growth factor A), IL8 (interleukin 8), IL6 (interleukin 6), ESR1 (estrogen receptor 1) and EGFR (epidermal growth factor receptor). These genes are promising candidate genes that can serve as useful diagnostic biomarkers and therapeutic targets. Our approach represents a novel strategy for prioritizing disease susceptibility genes.
authors: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. jilongliu@scau.edu.cn.
authors: Ji-Long
authors: JL
authors: Liu
authors: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. zm1586186423@126.com.
authors: Miao
authors: M
authors: Zhao
mesh_terms: D000465:Algorithms; D066246:ErbB Receptors / Q000235:genetics; D047628:Estrogen Receptor alpha / Q000378:metabolism; D005260:Female; D053263:Gene Regulatory Networks; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D016209:Interleukin-8 / Q000235:genetics; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D015850:Interleukin-6; D016209:Interleukin-8; D042461:Vascular Endothelial Growth Factor A; D066246:ErbB Receptors
keywords: ectopic pregnancy; gene prioritization; pathogenesis; text mining