title: Limited Effect of Dopaminergic Medication on Straight Walking and Turning in Early-to-Moderate Parkinson's Disease during Single and Dual Tasking.
abstract: BACKGROUND
  In Parkinson's disease (PD), the effects of dopaminergic medication on straight walking and turning were mainly investigated under single tasking (ST) conditions. However, multitasking situations are considered more daily relevant.
  
  
  METHODS
  Thirty-nine early-to-moderate PD patients performed the following standardized ST and dual tasks as fast as possible for 1 min during On- and Off-medication while wearing inertial sensors: straight walking and turning, checking boxes, and subtracting serial 7s. Quantitative gait parameters as well as velocity of the secondary tasks were analyzed.
  
  
  RESULTS
  The following parameters improved significantly in On-medication during ST: gait velocity during straight walking (p = 0.03); step duration (p = 0.048) and peak velocity (p = 0.04) during turning; velocity of checking boxes during ST (p = 0.04) and DT (p = 0.04). Velocity of checking boxes was the only parameter that also improved during DT.
  
  
  CONCLUSIONS
  These results suggest that dopaminergic medication does not relevantly influence straight walking and turning in early-to-moderate PD during DT.
authors: Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany.
authors: Morad
authors: M
authors: Elshehabi
authors: Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany.
authors: Katrin S
authors: KS
authors: Maier
authors: Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany.
authors: Sandra E
authors: SE
authors: Hasmann
authors: Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany.
authors: Susanne
authors: S
authors: Nussbaum
authors: Neurozentrum Sophienstrasse , Stuttgart , Germany.
authors: Heinz
authors: H
authors: Herbst
authors: Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany.
authors: Tanja
authors: T
authors: Heger
authors: Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany.
authors: Daniela
authors: D
authors: Berg
authors: Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany.
authors: Markus A
authors: MA
authors: Hobert
authors: Department of Neurodegeneration, Center for Neurology, Hertie Institute for Clinical and Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Disease (DZNE), Tuebingen, Germany.
authors: Walter
authors: W
authors: Maetzler
keywords: Parkinson’s disease; dual tasking; gait; turning; wearable sensors