title: Pneumatically actuated microvalve circuits for programmable automation of chemical and biochemical analysis.
abstract: Programmable microfluidic platforms (PMPs) are enabling significant advances in the utility of microfluidics for chemical and biochemical analysis. Traditional microfluidic devices are analogous to application-specific devices--a new device is needed to implement each new chemical or biochemical assay. PMPs are analogous to digital electronic processors--all that is needed to implement a new assay is a change in the order of operations conducted by the device. In this review, we introduce PMPs based on normally-closed microvalves. We discuss recent applications of PMPs in diverse fields including genetic analysis, antibody-based biomarker analysis, and chemical analysis in planetary exploration. Prospects, challenges, and future concepts for this emerging technology will also be presented.
authors: Department of Mechanical Engineering, Texas Tech University, Lubbock, TX, USA.
authors: Jungkyu
authors: J
authors: Kim
authors: Department of Chemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
authors: Amanda M
authors: AM
authors: Stockton
authors: HJ Science and Technology, Berkeley, CA 94720, USA.
authors: Erik C
authors: EC
authors: Jensen
authors: Department of Chemistry, University of California, Berkeley, CA 94720, USA. ramathies@berkeley.edu.
authors: Richard A
authors: RA
authors: Mathies
mesh_terms: D006801:Humans; D056656:Lab-On-A-Chip Devices; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods*