title: Efficacy and safety of ultrasound-guided continuous hyperthermic intraperitoneal perfusion chemotherapy for the treatment of malignant ascites: a midterm study of 36 patients.
abstract: BACKGROUND
  This study aimed to evaluate the efficacy and safety of ultrasound-guided continuous hyperthermic intraperitoneal perfusion chemotherapy (CHIPC) for the treatment of malignant ascites (MA).
  
  
  METHODS
  Between July 2011 and June 2013, 36 MA patients were prospectively and consecutively hospitalized for three cycles of elective CHIPC under ultrasound guidance, maintained at a constant flow rate of 400-600 mL/min normal saline containing 5-fluorouracil plus mitomycin or carboplatin and at a constant temperature of 43°C±0.2°C, for 90 minutes. Main outcome measures were ascites resolution, Karnofsky performance status (KPS), and serum tumor biomarkers at 2 weeks after the last cycle of CHIPC. All the patients underwent uneventful CHIPC as scheduled, and vital signs remained stable over CHIPC.
  
  
  RESULTS
  At 2 weeks after the last cycle of CHIPC, MA completely and partially resolved in 26 (72.2%) patients and eight (22.2%) patients, respectively; mean KPS score increased from pretreatment 61±9 to posttreatment 76±9 (P<0.001), and serum carcinoembryonic antigen and carbohydrate antigens 12-5 and 19-9 significantly decreased (all P<0.01).
  
  
  CONCLUSIONS
  The current study indicated that ultrasound-guided CHIPC is an effective and safe palliative treatment modality for MA with respect to MA resolution, patient's general well-being, and systemic disease control. The long-term benefit of CHIPC on overall survival remains to be investigated in MA patients.
authors: Second Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou Medical University, Guangzhou, People's Republic of China; Treatment Center of Body Cavitary Thermo-Perfusion, Cancer Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People's Republic of China.
authors: Yinbing
authors: Y
authors: Wu
authors: Second Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou Medical University, Guangzhou, People's Republic of China.
authors: Mingxin
authors: M
authors: Pan
authors: Treatment Center of Body Cavitary Thermo-Perfusion, Cancer Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People's Republic of China.
authors: Shuzhong
authors: S
authors: Cui
authors: Treatment Center of Body Cavitary Thermo-Perfusion, Cancer Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People's Republic of China.
authors: Mingchen
authors: M
authors: Ba
authors: Treatment Center of Body Cavitary Thermo-Perfusion, Cancer Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People's Republic of China.
authors: Zulong
authors: Z
authors: Chen
authors: Treatment Center of Body Cavitary Thermo-Perfusion, Cancer Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People's Republic of China.
authors: Qiang
authors: Q
authors: Ruan
keywords: continuous hyperthermic intraperitoneal perfusion chemotherapy; malignant ascites; peritoneal carcinomatosis; safety profile; ultrasound guidance