title: Combined model of the EBMT score modified model and the HCT-CI improves the stratification of high-risk patients undergoing unmanipulated haploidentical blood and marrow transplantation.
abstract: Both European Group for blood and marrow transplantation risk score (EBMT score modified model) and hematopoietic cell transplantation comorbidity index (HCT-CI) are suitable for evaluating patients undergoing unmanipulated haploidentical blood and marrow transplantation (HBMT), while the predictive capacity of the combined model following haploidentical transplantation is still unknown. In this study, we calculated and validated 322 consecutive unmanipulated HBMT patients. Patients in groups with HCT-CI scores of 0 or 1-2 exhibited similar overall survival (OS), non-relapse mortality (NRM), and relapse rates, independent of their EBMT score modified model. In the group in which patients' HCT-CI scores were ≥3, patients with high EBMT score modified model showed lower OS (p = 0.003) and higher NRM (p = 0.001) than did patients with low EBMT score. In conclusion, this combined model can be used to predict outcomes and may improve the stratification of high-risk patients following unmanipulated HBMT.
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;|b Collaborative Innovation Center of Hematology, Peking University , Beijing , China ;
authors: Ying-Jun
authors: YJ
authors: Chang
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;|c Department of Hematology , Shengjing Hospital, China Medical University , Shenyang , China ;
authors: Hong-Tao
authors: HT
authors: Wang
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Lan-Ping
authors: LP
authors: Xu
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Yu
authors: Y
authors: Wang
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Kai-Yan
authors: KY
authors: Liu
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Xiao-Hui
authors: XH
authors: Zhang
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Dai-Hong
authors: DH
authors: Liu
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Huan
authors: H
authors: Chen
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Yu-Hong
authors: YH
authors: Chen
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Feng-Rong
authors: FR
authors: Wang
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Wei-
authors: W
authors: Han
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Yu-Qian
authors: YQ
authors: Sun
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Chen-Hua
authors: CH
authors: Yan
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Fei-Fei
authors: FF
authors: Tang
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;
authors: Xiao-Dong
authors: XD
authors: Mo
authors: a Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University People's Hospital, Peking University Institute of Hematology , Beijing , China ;|b Collaborative Innovation Center of Hematology, Peking University , Beijing , China ;|d Peking-Tsinghua Center for Life Sciences , Beijing , China.
authors: Xiao-Jun
authors: XJ
authors: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000528:radiation effects / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006650:Histocompatibility Testing; D006801:Humans; D007938:Leukemia / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009026:Mortality; D011379:Prognosis; D012008:Recurrence; D018570:Risk Assessment; D014019:Tissue Donors; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
keywords: European Group for blood and marrow transplantation score; haploidentical transplantation; hematopoietic cell transplantation comorbidity index; leukemia