title: VDR and VDBP genes polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population.
abstract: BACKGROUND
  The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to the activation of macrophages and the deficiency of vitamin D seems to be involved in the risk of tuberculosis (TB). The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. In this study, variation in the VDR and VDBP genes was investigated in a Taiwanese population with TB.
  
  
  METHODS
  We typed four VDR polymorphisms of restriction endonuclease sites for ApaI, TaqI, BsmI, and FokI and three VDBP polymorphisms-Thr420Lys, Asp416Glu, and Cys299Cys-in 198 patients with TB and 170 healthy volunteers.
  
  
  RESULTS
  VDR TaqI, VDR BsmI, and VDBP Asp416Glu were significantly associated with TB susceptibility. Odd ratios of risk genotypes of the above three polymorphisms were 2.16 (95% confidence interval 1.01, 4.65), 2.14 (95% confidence interval 1.06, 4.31), and 2.24 (95% confidence interval 1.04, 4.80), respectively. VDBP haplotype analysis showed Gc1f carriers associated to TB.
  
  
  CONCLUSIONS
  The polymorphisms in the VDR and VDBP genes appeared to be responsible for host susceptibility to human TB in a Taiwanese population.
authors: Chest Medicine Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
authors: Shih-Wei
authors: SW
authors: Lee
authors: Chest Medicine Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan.
authors: Tzu-Yi
authors: TY
authors: Chuang
authors: Chest Medicine Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan.
authors: Hsiu-Han
authors: HH
authors: Huang
authors: Chest Medicine Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan.
authors: Chi-Wei
authors: CW
authors: Liu
authors: Department of Life Sciences, National Central University, Taoyuan, Taiwan.
authors: Yung-Hsi
authors: YH
authors: Kao
authors: Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address: lshwu@hotmail.com.
authors: Lawrence Shih-Hsin
authors: LS
authors: Wu
mesh_terms: D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008262:Macrophage Activation / Q000235:genetics / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018167:Receptors, Calcitriol / Q000235:genetics*; D013624:Taiwan; D014376:Tuberculosis / Q000235:genetics*; D014809:Vitamin D-Binding Protein / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human; D014809:Vitamin D-Binding Protein
keywords: VDBP; VDR; polymorphism; tuberculosis