title: Examining Biopsychosocial Factors in Relation to Multiple Pain Features in Pediatric Sickle Cell Disease.
abstract: To examine biopsychosocial variables in relation to multiple pain features in pediatric sickle cell disease (SCD).
  
  
  
  76 children with SCD (M = 14.05, SD = 3.26), ages 8-19 years, and 70 caregivers completed measures of coping, mood, and family functioning and reported on multiple pain features via retrospective interviews during routine hematological visits. Sickle cell genotype and health care utilization were collected via medical record review. Using hierarchical regression, biological (genotype), child psychological (coping and mood), and social factors (caregiver coping and family functioning) were evaluated in relation to multiple pain features.
  
  
  
  Genotype was associated with pain intensity, and child psychological factors were associated with pain frequency. Multiple biopsychosocial factors were related to health care utilization.
  
  
  
  Biopsychosocial factors may have distinct relationships with pain features in pediatric SCD. Understanding these relationships may refine the biopsychosocial model and inform integrated medical and psychosocial approaches in SCD.
authors: Department of Psychology, University of South Carolina, Department of Pediatrics, Medical University of South Carolina, and schlenz@musc.edu.
authors: Alyssa M
authors: AM
authors: Schlenz
authors: Department of Psychology, University of South Carolina.
authors: Jeffrey
authors: J
authors: Schatz
authors: Department of Pediatrics, University of South Carolina School of Medicine.
authors: Carla W
authors: CW
authors: Roberts
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics / Q000523:psychology; D017028:Caregivers; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005195:Family Relations; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010146:Pain / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D010147:Pain Measurement; D012189:Retrospective Studies; D012307:Risk Factors; D012931:Social Environment; D055815:Young Adult
keywords: children; pain; sickle cell disease