title: Elevated Serum CD95/FAS and HIF-1α Levels, but Not Tie-2 Levels, May Be Biomarkers in Patients With Severe Endometriosis: A Preliminary Report.
abstract: To evaluate serum values of cluster of differentiation 95 (CD95/FAS), hypoxia-inducible factor 1-alpha (HIF-1α), and tyrosine kinase receptor 2 (Tie-2) as possible biomarkers of disease presence and severity in women with endometriosis, and to characterize the changes in these values in women with stage I/II and stage III/IV endometriosis.
  
  
  
  Prospective study (Canadian Task Force classification I).
  
  
  
  University hospital.
  
  
  
  Thirty women with endometriosis and 30 healthy women without endometriosis.
  
  
  
  For the diagnosis of endometriosis and prediction of its severity, we measured the serum levels of CD95/FAS, which assess apoptotic conditions, and of HIF-1α and Tie-2, which assess angiogenesis. Endometriosis was diagnosed and staged through surgical laparoscopy and later confirmed histologically. During the surgery, the patients with endometriosis were divided into 2 groups based on disease stage. Eleven patients had stage I/II endometriosis, and 19 had stage III/IV endometriosis.
  
  
  
  Endometriosis was associated with increased serum CD95/FAS and HIF-1α levels, but not Tie-2 levels. We also determined that stage III/IV endometriosis was associated with higher serum CD95/FAS and HIF-1α levels, but not Tie-2 levels, compared with stage I/II endometriosis.
  
  
  
  Endometriosis, in accordance with its severity, increases serum CD95/FAS and HIF-1α levels, but not Tie-2 levels. These biomarkers may be useful for reproductive surgeons to improve the quality of counseling women about the presence and severity of endometriosis.
authors: Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey. Electronic address: karakussavas@yahoo.com.tr.
authors: Savas
authors: S
authors: Karakus
authors: Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Enver
authors: E
authors: Sancakdar
authors: Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Ozlem
authors: O
authors: Akkar
authors: Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Caglar
authors: C
authors: Yildiz
authors: Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Ozlem
authors: O
authors: Demirpence
authors: Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Ali
authors: A
authors: Cetin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004715:Endometriosis / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000097:blood*; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D011237:Predictive Value of Tests; D011446:Prospective Studies; D042787:Receptor, TIE-2 / Q000097:blood*; D012720:Severity of Illness Index; D055815:Young Adult; D019014:fas Receptor / Q000097:blood*
chemical_list: D015415:Biomarkers; C491901:FAS protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D019014:fas Receptor; D042787:Receptor, TIE-2
keywords: CD95/FAS; Endometriosis; HIF-1α; Tie-2