title: Can venous ProBNP levels predict placenta accreta?
abstract: OBJECTIVE
  Placenta previa (PP) is a potential life-threatening pregnancy complication. Pro-brain natriuretic peptide (ProBNP), creatine kinase (CK), cardiac form of CK (CK-MB) and Troponin I are circulatory biomarkers related to cardiac functions. We aimed to determine whether these biomarkers are related to PP and placenta accreta.
  
  
  METHODS
  In this case-control study, fifty-four pregnant women who attended our tertiary care center for perinatology with the diagnosis of PP totalis, and of them, 14 patients with placenta accreta were recruited as the study groups. Forty-six uncomplicated control patients who were matched for age, BMI were also included. Maternal venous ProBNP, CK, CK-MB and Troponin I levels were compared between the three groups.
  
  
  RESULTS
  Obstetric history characteristics were comparable among groups, generally. CK and CK-MB levels were similar among three groups. Troponin I levels in the previa and accreta groups were significantly higher than the controls. ProBNP levels in the accreta group were significantly higher than other two groups. The multivariate regression model revealed that ProBNP could predict placental adhesion anomalies.
  
  
  CONCLUSIONS
  Troponin I and ProBNP levels in PP cases were higher than controls and ProBNP could predict placenta accreta.
authors: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Care Training and Research Hospital , Ankara , Turkey.
authors: Ali Ozgur
authors: AO
authors: Ersoy
authors: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Care Training and Research Hospital , Ankara , Turkey.
authors: Efser
authors: E
authors: Oztas
authors: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Care Training and Research Hospital , Ankara , Turkey.
authors: Sibel
authors: S
authors: Ozler
authors: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Care Training and Research Hospital , Ankara , Turkey.
authors: Ebru
authors: E
authors: Ersoy
authors: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Care Training and Research Hospital , Ankara , Turkey.
authors: Kudret
authors: K
authors: Erkenekli
authors: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Care Training and Research Hospital , Ankara , Turkey.
authors: Dilek
authors: D
authors: Uygur
authors: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Care Training and Research Hospital , Ankara , Turkey.
authors: Ali Turhan
authors: AT
authors: Caglar
authors: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Care Training and Research Hospital , Ankara , Turkey.
authors: Nuri
authors: N
authors: Danisman
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D052279:Creatine Kinase, MB Form / Q000097:blood*; D005260:Female; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010921:Placenta Accreta / Q000175:diagnosis*; D010923:Placenta Previa / Q000175:diagnosis*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012307:Risk Factors; D018709:Statistics, Nonparametric; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I; D020097:Natriuretic Peptide, Brain; D052279:Creatine Kinase, MB Form
keywords: Cardiac biomarkers; Troponin I; placenta accreta; placenta previa; pro-brain natriuretic peptide