title: Enantiomeric resolution of multiple chiral centres racemates by capillary electrophoresis.
abstract: Enantiomeric resolution of multichiral centre racemates is an important area as some multichiral centre racemates are of great medicinal importance. However, enantioseparation of such types of racemates is a challenging task. Amongst many analytical techniques, capillary electrophoresis is a powerful technique and may be used to resolve such racemates. Only few papers are available describing enantiomeric resolution of such racemates. Therefore, efforts have been made to describe the enantiomeric resolution of multichiral centre racemates by capillary electrophoresis. This article discusses the importance of multichiral racemates, the need for capillary electrophoresis in enantiomeric resolution and chiral resolution of multichiral centre racemates using various chiral selectors. Further, attempts have been made to discuss the future challenges and prospects of enantiomeric resolution of multichiral racemates. The various chiral selectors used for the purpose are chiral crown ether, cyclodextrins, polysaccharides, macrocyclic glycopeptide antibiotics and ligand exchange.
authors: Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi, 110025, India.
authors: Imran
authors: I
authors: Ali
authors: Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi, 110025, India.
authors: Mohd
authors: M
authors: Suhail
authors: Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia.
authors: Zeid A
authors: ZA
authors: Al-Othman
authors: Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia.
authors: Abdulrahman
authors: A
authors: Alwarthan
authors: Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, 12311, Egypt.
authors: Hassan Y
authors: HY
authors: Aboul-Enein
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003505:Cyclodextrins; D004364:Pharmaceutical Preparations
keywords: capillary electrophoresis; chiral selectors; enantiomeric resolution; future challenges and prospectives; multiple chiral centre racemates