title: Recent Advancement and Technological Aspects of Pulsatile Drug Delivery System - A Laconic Review.
abstract: BACKGROUND
  Pulsatile drug delivery system (PDDS) shows potential significance in the field of drug delivery to release the maximum amount of drug at a definite site and at specific time. PDDS are mainly time controlled delivery devices having a definite pause period for drug release, which is not affected by acidity, alkalinity, motility and enzymes present in the gastrointestinal tract. Pulsatile medication possess the potential to deliver the drugs in the therapy of diseases where drug dose is essential during sleep, drugs having greater first pass metabolism and absorption at precise location in digestive tract.
  
  
  OBJECTIVE
  The review article, discuss the general concepts, marketed formulations and patents or any other recent advancement in pulsatile release technology. It also highlights on diseases requiring therapy by pulsatile release, various researches on herbal pulsatile formulations and quality control aspects of PDDS.
  
  
  CONCLUSIONS
  Pulsatile medication possess the potential to deliver the drugs in the therapy of diseases where drug dose is essential during sleep, drugs having greater first pass metabolism and absorption at precise location in digestive tract.
authors: Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Kangra (H.P) - 177101, India.
authors: Vinay
authors: V
authors: Pandit
authors: Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Kangra (H.P) - 177101, India.
authors: Ajay
authors: A
authors: Kumar
authors: Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Kangra (H.P) - 177101, India.
authors: Mahendra S
authors: MS
authors: Ashawat
authors: Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Kangra (H.P) - 177101, India.
authors: Chander P
authors: CP
authors: Verma
authors: Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Kangra (H.P) - 177101, India.
authors: Pravin
authors: P
authors: Kumar
mesh_terms: D000284:Administration, Oral; D003692:Delayed-Action Preparations; D055870:Drug Chronotherapy; D004339:Drug Compounding; D016503:Drug Delivery Systems; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations
keywords: Pulsatile; chronotherapy; drug delivery; drug formation; herbal; lag time