title: Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair.
abstract: Research over the past decade on the cell-biomaterial interface has shifted to the third dimension. Besides mimicking the native extracellular environment by 3D cell culture, hydrogels offer the possibility to generate well-defined 3D biofabricated tissue analogs. In this context, gelatin-methacryloyl (gelMA) hydrogels have recently gained increased attention. This interest is sparked by the combination of the inherent bioactivity of gelatin and the physicochemical tailorability of photo-crosslinkable hydrogels. GelMA is a versatile matrix that can be used to engineer tissue analogs ranging from vasculature to cartilage and bone. Convergence of biological and biofabrication approaches is necessary to progress from merely proving cell functionality or construct shape fidelity towards regenerating tissues. GelMA has a critical pioneering role in this process and could be used to accelerate the development of clinically relevant applications.
authors: Department of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, PO 85500, Utrecht, GA, 3508, The Netherlands.
authors: Barbara J
authors: BJ
authors: Klotz
authors: Department of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, PO 85500, Utrecht, GA, 3508, The Netherlands.
authors: Debby
authors: D
authors: Gawlitta
authors: Department of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, PO 85500, Utrecht, GA, 3508, The Netherlands.
authors: Antoine J W P
authors: AJWP
authors: Rosenberg
authors: Department of Orthopaedics, University Medical Center Utrecht, PO Box 85500, Utrecht, GA, 3508, The Netherlands; Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, Utrecht, CM, 3584, The Netherlands. Electronic address: j.malda@umcutrecht.nl.
authors: Jos
authors: J
authors: Malda
authors: Department of Orthopaedics, University Medical Center Utrecht, PO Box 85500, Utrecht, GA, 3508, The Netherlands; Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK.
authors: Ferry P W
authors: FPW
authors: Melchels
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002356:Cartilage / Q000502:physiology; D005780:Gelatin; D006801:Humans; D020100:Hydrogels; D008689:Methacrylates; D051379:Mice; D023822:Tissue Engineering / Q000379:methods*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D008689:Methacrylates; D005780:Gelatin
keywords: biofabrication; gelatin-methacryloyl; hydrogel; photo-crosslinking; regenerative medicine; tissue engineering