title: Malignant Myopericytoma: Report of a New Case and Review of the Literature.
abstract: Malignant myopericytoma is a rare entity with only 8 cases reported in the English literature. The authors report a case of a 65-year-old man with a slow-growing 8-cm nodule on the right arm. Marginal excision was performed, and a diagnosis of malignant myopericytoma was made based on histopathologic and immunohistochemical aspects. These tumors are characterized by a proliferation of round-to-spindle cells of myoid appearance in a concentric perivascular arrangement, along with malignant cytological findings. By immunochemistry, the cells were positive for smooth muscle actin and negative for desmin, cytokeratin AE1/AE3, S100 protein, Melan-A, p63, CD99, bcl-2, CD10, and STAT-6. No membranous expression of type IV collagen was observed. These tumors are associated with aggressive biological behavior and most develops metastases.
authors: *Dermatopathology Department, Centro Hospitalar do Algarve, Faro, Portimão, Portugal; †Clínica Universitária de Dermatologia de Lisboa, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Portugal; and ‡Dermatophatologisches Gemeinschaftslabor, Friedrichshafen, Germany.
authors: Agostini
authors: A
authors: Patrick
authors: Luís
authors: L
authors: Soares-de-Almeida
authors: Kutzner
authors: K
authors: Heinz
mesh_terms: D000368:Aged; D001132:Arm / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D006393:Hemangiopericytoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012983:Soft Tissue Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor