title: Efficacy of three different pulpotomy agents in primary molars: a randomized control trial.
abstract: OBJECTIVE
  To compare the clinical and radiographic efficacy of Biodentine™, ProRoot®White Mineral Trioxide Aggregate (WMTA) and Tempophore™as pulpotomy medicaments in the treatment of carious primary molars.
  
  
  METHODS
  A parallel-design, randomized controlled trial was developed. Patients above 3 years of age with carious primary teeth with vital pulps without spontaneous pain or history of swelling were included. Fifty-eight patients (82 teeth) with a mean age of 4.79 ± 1.23 years were included. The teeth were randomized, blinded and allocated to one of the three groups (Biodentine™, ProRoot®WMTA or Tempophore™) for pulpotomy treatment. All teeth were followed up clinically and radiographically (after 6, 12 and 18 months) by two blinded calibrated investigators. A generalized estimating equation (GEE), Wald chi-square test and an intention-to-treat analysis (ITT) with 'last carried forward' approach were performed using Statistical Package for Social Sciences v 21.0 (IBM Corp., Armonk, NK, USA).
  
  
  RESULTS
  Forty-six patients and 69 teeth were available for follow-up after 18 months. Clinical success (radiographic success in parenthesis) was 95.24% (94.4%), 100% (90.9%) and 95.65% (82.4%) in the Biodentine™, ProRoot®WMTA and Tempophore™groups, respectively, but the difference was not significant. Pulp canal obliteration was significantly different amongst the experimental groups as the Biodentine™group exhibited significantly more pulp canal obliteration when compared to the ProRoot®WMTA group at 6 months (P = 0.008) and 18 months (P = 0.003).
  
  
  CONCLUSIONS
  After 18-month follow-up, there was no significant difference between Biodentine™in comparison with ProRoot®WMTA or Tempophore™.
authors: Department of Paediatric Dentistry and Special Care, PAECOMEDIS Research Cluster, Ghent University, Ghent, Belgium.
authors: S
authors: S
authors: Rajasekharan
authors: Department of Paediatric Dentistry and Special Care, PAECOMEDIS Research Cluster, Ghent University, Ghent, Belgium.
authors: L C
authors: LC
authors: Martens
authors: Department of Paediatric Dentistry and Special Care, PAECOMEDIS Research Cluster, Ghent University, Ghent, Belgium.
authors: J
authors: J
authors: Vandenbulcke
authors: Faculty of Medicine and Pharmacy, MOND-EDWE, Vrije Universiteit Brussel, Brussel, Belgium.
authors: W
authors: W
authors: Jacquet
authors: Department of Oral Health Sciences, Vrije Universiteteit Brussel, Brussel, Belgium.
authors: P
authors: P
authors: Bottenberg
authors: Department of Paediatric Dentistry and Special Care, PAECOMEDIS Research Cluster, Ghent University, Ghent, Belgium.
authors: R G E C
authors: RG
authors: Cauwels
mesh_terms: D017607:Aluminum Compounds; D017610:Calcium Compounds; D002648:Child; D002675:Child, Preschool; D003407:Creosote; D003731:Dental Caries / Q000000981:diagnostic imaging / Q000628:therapy*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006847:Hydrocarbons, Iodinated; D057194:Intention to Treat Analysis; D008297:Male; D008963:Molar; D010087:Oxides; D057872:Pulp Capping and Pulpectomy Agents; D011672:Pulpotomy; D011861:Radiography, Dental; D017640:Silicates; D013943:Thymol; D014094:Tooth, Deciduous; D016896:Treatment Outcome
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D006847:Hydrocarbons, Iodinated; D010087:Oxides; D057872:Pulp Capping and Pulpectomy Agents; D017640:Silicates; C086631:mineral trioxide aggregate; D013943:Thymol; C506393:tricalcium silicate; D003407:Creosote; C034472:Septodont
keywords: Biodentine; Tempophore; mineral trioxide aggregate; pulp therapy; pulpotomy