title: Which pain intensity scale from the Brief Pain Inventory correlates most highly with functional interference scores in patients experiencing taxane-induced arthralgia and myalgia?
abstract: The purpose of this study was to assess which pain intensity dimension scale (worst, least, average, or current pain) from the Brief Pain Inventory (BPI) correlates most highly with functional interference scores in patients experiencing taxane-induced arthralgia and myalgia.
  
  
  
  Breast cancer patients scheduled to receive docetaxel, paclitaxel, or albumin-bound paclitaxel (nab-paclitaxel) were enrolled in the study. Patients completed an initial baseline questionnaire and subsequently filled out a diary based on the BPI on days 1-7, 14, and 21 for three consecutive treatment cycles. Pain scores for worst, least, average, and current pain intensity dimensions as well as pain interference scores were recorded in the diaries and questionnaires using the BPI. Worst, least, average, and current pain scores were correlated with functional pain interference scores using Spearman's rank correlation coefficients. A general linear mixed model of each functional interference measure was performed over time for cycles 1-3 with each pain intensity dimension scale.
  
  
  
  Among worst, average, least, and current joint pain dimensions, average joint pain scores correlated best with all BPI interference responses while average muscle pain scores correlated best with all BPI interference responses except for sleeping probability and normal work.
  
  
  
  We recommend the BPI scale measuring average pain for future studies evaluating pain scores in patients experiencing taxane-induced arthralgia and myalgia.
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Nicholas
authors: N
authors: Chiu
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Liying
authors: L
authors: Zhang
authors: North York General Hospital, Toronto, ON, Canada.
authors: Daniela
authors: D
authors: Gallo-Hershberg
authors: National Cancer Centre, Singapore, Singapore, Singapore.
authors: Rebecca
authors: R
authors: Dent
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Leonard
authors: L
authors: Chiu
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Mark
authors: M
authors: Pasetka
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Jenna
authors: J
authors: van Draanen
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Ronald
authors: R
authors: Chow
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Henry
authors: H
authors: Lam
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Sunil
authors: S
authors: Verma
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Jordan
authors: J
authors: Stinson
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Erica
authors: E
authors: Stacey
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada. Edward.Chow@sunnybrook.ca.
authors: Edward
authors: E
authors: Chow
authors: Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors: Carlo
authors: C
authors: DeAngelis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063806:Myalgia / Q000139:chemically induced*; D010147:Pain Measurement / Q000379:methods*; D011795:Surveys and Questionnaires; D043823:Taxoids / Q000009:adverse effects*
chemical_list: D043823:Taxoids
keywords: Arthralgia; Brief pain inventory; Myalgia; Pain score; Taxane