title: A First Step in the Quest for the Active Constituents in Filipendula ulmaria (Meadowsweet): Comprehensive Phytochemical Identification by Liquid Chromatography Coupled to Quadrupole-Orbitrap Mass Spectrometry.
abstract: Filipendula ulmaria (meadowsweet) is traditionally used for the treatment of inflammatory diseases and as a diuretic and antirheumatic. Extracts of Filipendulae herba are on the market in the European Union as food supplements. Nevertheless, its active constituents remain to be revealed. During this study, the phytochemical composition of Filipendulae Ulmariae Herba was comprehensively characterised for the first time with two complementary generic ultrahigh-performance liquid chromatography-photodiode array-accurate mass mass spectrometry methods. Selective ion fragmentation experiments with a hybrid quadrupole-orbital trap mass spectrometer significantly contributed to compound identification: a total of 119 compounds were tentatively identified, 69 new to F. ulmaria. A rich diversity of phenolic constituents was detected and only a few non-phenolic phytochemicals were observed. Metabolisation and pharmacological studies should be conducted to investigate which of these constituents or metabolites there of contribute to the activity of F. ulmaria after oral intake.
authors: University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium.
authors: Sebastiaan
authors: S
authors: Bijttebier
authors: University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium.
authors: Anastasia
authors: A
authors: Van der Auwera
authors: Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology (SCT), Mol, Belgium.
authors: Stefan
authors: S
authors: Voorspoels
authors: Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology (SCT), Mol, Belgium.
authors: Bart
authors: B
authors: Noten
authors: University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium.
authors: Nina
authors: N
authors: Hermans
authors: University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium.
authors: Luc
authors: L
authors: Pieters
authors: University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium.
authors: Sandra
authors: S
authors: Apers
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D031984:Filipendula / Q000737:chemistry*; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry; D010636:Phenols / Q000032:analysis / Q000737:chemistry; D064209:Phytochemicals / Q000032:analysis / Q000737:chemistry; D010840:Phytosterols / Q000032:analysis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D044945:Proanthocyanidins / Q000032:analysis / Q000737:chemistry; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D005419:Flavonoids; D010636:Phenols; D064209:Phytochemicals; D010840:Phytosterols; D044945:Proanthocyanidins