title: Rationale and Prospects of Targeting Bacterial Two-component Systems for Antibacterial Treatment of Cystic Fibrosis Patients.
abstract: Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkholderia cepacia complex and especially Pseudomonas aeruginosa are more frequently seen. P. aeruginosa is a turning point in the respiratory disease in CF and its predominance increases with age. Bacteria use a variety of two-component systems (TCS) to differentially express virulence factors involved in both acute and chronic infections. Here, we review bacterial TCS as targets for antibacterial treatment for CF patients.
authors: Host-microbe Interactomics Group, Department of Animal Sciences, Wageningen University, Wageningen. Netherlands.
authors: Nadya
authors: N
authors: Velikova
authors: Jerry M
authors: JM
authors: Wells
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism* / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000187:drug effects; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D006801:Humans; D058990:Molecular Targeted Therapy; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D015398:Signal Transduction / Q000187:drug effects; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D037521:Virulence Factors
keywords: Bacterial infections; antibacterial treatment; cystic fibrosis; pathogen; respiratory infection; two-component systems