title: Intrinsic brain subsystem associated with dietary restraint, disinhibition and hunger: an fMRI study.
abstract: Eating behaviors are closely related to body weight, and eating traits are depicted in three dimensions: dietary restraint, disinhibition, and hunger. The current study aims to explore whether these aspects of eating behaviors are related to intrinsic brain activation, and to further investigate the relationship between the brain activation relating to these eating traits and body weight, as well as the link between function connectivity (FC) of the correlative brain regions and body weight. Our results demonstrated positive associations between dietary restraint and baseline activation of the frontal and the temporal regions (i.e., food reward encoding) and the limbic regions (i.e., homeostatic control, including the hypothalamus). Disinhibition was positively associated with the activation of the frontal motivational system (i.e., OFC) and the premotor cortex. Hunger was positively related to extensive activations in the prefrontal, temporal, and limbic, as well as in the cerebellum. Within the brain regions relating to dietary restraint, weight status was negatively correlated with FC of the left middle temporal gyrus and left inferior temporal gyrus, and was positively associated with the FC of regions in the anterior temporal gyrus and fusiform visual cortex. Weight status was positively associated with the FC within regions in the prefrontal motor cortex and the right ACC serving inhibition, and was negatively related with the FC of regions in the frontal cortical-basal ganglia-thalamic circuits responding to hunger control. Our data depicted an association between intrinsic brain activation and dietary restraint, disinhibition, and hunger, and presented the links of their activations and FCs with weight status.
authors: College of Mechanical and Electronic Engineering, Northwest A&F University, No 22 Xinong Road, Yangling Shaanxi, 712100, China.|School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.
authors: Jizheng
authors: J
authors: Zhao
authors: College of Mechanical and Electronic Engineering, Northwest A&F University, No 22 Xinong Road, Yangling Shaanxi, 712100, China.
authors: Mintong
authors: M
authors: Li
authors: School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.
authors: Yi
authors: Y
authors: Zhang
authors: College of Mechanical and Electronic Engineering, Northwest A&F University, No 22 Xinong Road, Yangling Shaanxi, 712100, China.
authors: Huaibo
authors: H
authors: Song
authors: School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.
authors: Karen M
authors: KM
authors: von Deneen
authors: College of Mechanical and Electronic Engineering, Northwest A&F University, No 22 Xinong Road, Yangling Shaanxi, 712100, China.
authors: Yinggang
authors: Y
authors: Shi
authors: Department of Psychiatry & McKnight Brain Institute, University of Florida, 1149 South Newell Drive, Gainesville, FL, 32610, USA.|Department of Psychology, Southwest University, Chongqing, 400715, China.
authors: Yijun
authors: Y
authors: Liu
authors: College of Mechanical and Electronic Engineering, Northwest A&F University, No 22 Xinong Road, Yangling Shaanxi, 712100, China. hdj168@nwsuaf.edu.cn.
authors: Dongjian
authors: D
authors: He
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D056344:Executive Function / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D006815:Hunger / Q000502:physiology*; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012146:Rest; D055815:Young Adult
keywords: Functional connectivity; Functional magnetic resonance imaging; Obesity; Resting state; Three factor eating questionnaire