title: Analysis of association between common variants in the SLCO6A1 gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population.
abstract: OBJECTIVE
  The SLCO6A1 gene belongs to a superfamily of genes which is known to be a solute carrier family of OATPs (SLCO). The SLCO6A1 gene encodes OATP6A1 protein in humans. A previous genome-wide association study (GWAS) of schizophrenia conducted in the Swedish population demonstrated a significant association of rs6878284, which is located in the SLCO6A1 gene, with schizophrenia. To further investigate whether this gene is also a risk locus for schizophrenia (SCZ), bipolar disorder (BPD) and major depressive disorder (MDD) in the Han Chinese population, a case-control study was designed.
  
  
  METHODS
  In total 1,248 unrelated SCZ cases, 1,344 BPD cases, 1,056 unrelated MDD cases and 1,248 normal controls were analysed in this study. We genotyped five SNPs using the Sequenom MassARRAY platform.
  
  
  RESULTS
  We found no association of rs6878284 with SCZ [Corrected Pallele = 0.969, Corrected Pgenotype = 0.997]. Furthermore, we found a statistically significant association of the rs7734060 genotype with MDD after correction [rs7734060: Corrected Pallele = 0.114, Corrected Pgenotype = 0.036] in the Han Chinese population.
  
  
  CONCLUSIONS
  This is the first study which reveals no association of rs6878284 with SCZ and also predicts that rs7734060 could be a risk locus for MDD in the Han Chinese population.
authors: a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;|e Dept. Of Chemistry , University of Azad Jammu and Kashmir , Muzaffarabad , 13100 , Pakistan.
authors: Raja Amjad Waheed
authors: RA
authors: Khan
authors: a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;|b Shanghai Key Laboratory of Psychotic Disorders , Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine , Shanghai , 200030 , P.R. China ;
authors: Jianhua
authors: J
authors: Chen
authors: a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;
authors: Meng
authors: M
authors: Wang
authors: a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;
authors: Zujia
authors: Z
authors: Wen
authors: a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;
authors: Jiawei
authors: J
authors: Shen
authors: a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;
authors: Zhijian
authors: Z
authors: Song
authors: a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;
authors: Zhiqiang
authors: Z
authors: Li
authors: a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;
authors: Qingzhong
authors: Q
authors: Wang
authors: a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;
authors: Wenjin
authors: W
authors: Li
authors: b Shanghai Key Laboratory of Psychotic Disorders , Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine , Shanghai , 200030 , P.R. China ;
authors: Yifeng
authors: Y
authors: Xu
authors: c Shanghai Changning Mental Health Center , 299 Xiehe Road , Shanghai , 200042 , P.R. China ;
authors: Weidong
authors: W
authors: Ji
authors: a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;|c Shanghai Changning Mental Health Center , 299 Xiehe Road , Shanghai , 200042 , P.R. China ;|d Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University , Shanghai , 200042 , P.R. China ;
authors: Yongyong
authors: Y
authors: Shi
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D027361:Organic Anion Transporters / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult
chemical_list: D027361:Organic Anion Transporters; C487009:SLCO6A1 protein, human
keywords: Han Chinese; Major depressive disorder; SLCO6A1; case–control study; genetic association