title: [Oxidative Stress Level of Vanadium-exposed Workers].
abstract: OBJECTIVE
  To determine the oxidative stress level in peripheral blood of vanadium-exposed workers, as an indication of population health effect of vanadium on human neurobehavioral system.
  
  
  METHODS
  86 vanadium-exposed workers and 65 non-exposed workers were recruited by cluster sampling. A questionnaire was administered to collect demographic and occupational exposure information. Serum activity of superoxide dismutase (SOD), inducible nitric oxide synthase (iNOS) and malonaldehyde (MDA) contents were detected by kit assay. The differences in oxidative stress level between vanadium-exposed and non-exposed workers were compared.
  
  
  RESULTS
  Vanadium-exposed workers had higher levels of MDA contents than the controls. The total superoxide dismutase(T-SOD) activity in vanadium-exposed workers was significantly lower than that in the controls, which was associated with lowered levels of manganese superoxide dismutase (Mn-SOD) activity. No changes in serum levels of cupro-zinc superoxide dismutase (CuZn-SOD) was found in vanadium-exposed workers. No difference in iNOS activity was found between vanadium-exposed workers and controls.
  
  
  CONCLUSIONS
  Vanadium exposure increases free radical production in serum and reduces antioxidant capacity. But the relationship between vanadium exposure and iNOS damage remains uncertain.
authors: Teng-da
authors: TD
authors: Wei
authors: Shun-pin
authors: SP
authors: Li
authors: Yun-xing
authors: YX
authors: Liu
authors: Chun-ping
authors: CP
authors: Tan
authors: Juan
authors: J
authors: Li
authors: Zu-hui
authors: ZH
authors: Zhang
authors: Ya-jia
authors: YJ
authors: Lan
authors: Qin
authors: Q
authors: Zhang
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D006801:Humans; D008315:Malondialdehyde / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D016273:Occupational Exposure / Q000009:adverse effects*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism; D014639:Vanadium / Q000009:adverse effects*
chemical_list: D000975:Antioxidants; D014639:Vanadium; D008315:Malondialdehyde; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D013482:Superoxide Dismutase