title: Preventing Congenital Cytomegalovirus Infection: Protection to a 'T'.
abstract: A lack of knowledge about the correlates of maternal immunity required for protection of the placenta and fetus against congenital cytomegalovirus (CMV) transmission has complicated vaccine development. New work from Bialas and colleagues demonstrates a critical role for maternal CD4(+) T cells in controlling viremia and preventing CMV-associated fetal disease.
authors: Center for Infectious Diseases and Microbiology Translational Research, Division of Pediatric Infectious Diseases and Immunology, University of Minnesota Medical School, 2001 6(th) Street SE, Minneapolis, MN 55455, USA. Electronic address: schleiss@umn.edu.
authors: Mark R
authors: MR
authors: Schleiss
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000517:prevention & control*; D005260:Female; D018445:Infectious Disease Transmission, Vertical; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
keywords: animal models; congenital cytomegalovirus infection; cytomegalovirus immunity; cytomegalovirus vaccine; pentameric complex; placenta