title: Two cases of cisplatin-induced permanent renal failure following neoadjuvant chemotherapy for esophageal cancer.
abstract: BACKGROUND
  We experienced two esophageal cancer patients who developed severe acute renal failure after neoadjuvant chemotherapy with cisplatin and 5-fluorourasil.
  
  
  METHODS
  After administration of cisplatin, their serum creatinine increased gradually until they required hemodialysis and their renal failure was permanent. In both cases, renal biopsy examination indicated partial recovery of the proximal tubule, but renal function did not recover. After these events, one patient underwent definitive radiotherapy and the other underwent esophagectomy for their esophageal cancers, while continuing dialysis. Both patients are alive without cancer recurrence.
  
  
  CONCLUSIONS
  In these two cases of cisplatin-induced renal failure, renal biopsy examination showed only slight disorder of proximal tubules and tendency to recover.
  
  
  CONCLUSIONS
  Although cisplatin-related nephrotoxicity is a well-recognized complication, there have been few reports of renal failure requiring hemodialysis in cancer patients. In this report, we present their clinical courses and the pathological findings of cisplatin-related renal failure.
authors: Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan. Electronic address: sa-tomo@gipc.akita-u.ac.jp.
authors: Tomohiko
authors: T
authors: Sasaki
authors: Department of Surgery, Comprehensive Cancer Control, Akita University Graduate School of Medicine, Akita, Japan.
authors: Satoru
authors: S
authors: Motoyama
authors: Department of Hematology, Oncology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
authors: Atsushi
authors: A
authors: Komatsuda
authors: Department of Clinical Oncology, Akita University Graduate School of Medicine, Akita, Japan.
authors: Hiroyuki
authors: H
authors: Shibata
authors: Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan.
authors: Yusuke
authors: Y
authors: Sato
authors: Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan.
authors: Kei
authors: K
authors: Yoshino
authors: Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan.
authors: Akiyuki
authors: A
authors: Wakita
authors: Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan.
authors: Hajime
authors: H
authors: Saito
authors: Radiology, Akita University Graduate School of Medicine, Akita, Japan.
authors: Akira
authors: A
authors: Anbai
authors: Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
authors: Mario
authors: M
authors: Jin
authors: Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan.
authors: Yoshihiro
authors: Y
authors: Minamiya
keywords: Cisplatin; Esophageal cancer; Neoadjuvant chemotherapy; Renal failure