title: Clinicopathological pattern of cranial unifocal Langerhans cell histiocytosis: A study at medical college hospital.
abstract: BACKGROUND
  Eosinophilic granuloma (EG) of bone refers to a generally benign form of Langerhans cell histiocytosis localized to the bone. Patients may present with a solitary lesion (monostotic) or multiple sites of involvement (polyostotic).
  
  
  METHODS
  This study was done to evaluate the clinicopathological pattern of 6 cases of EGs of the skull diagnosed at a tertiary care hospital. All patients of EG were included with the help of medical records over a 5-year period that is, November 2009 to November 2014. They all had been preoperatively evaluated by skull X-ray and computed tomography. To rule out a multifocal disease scintigraphy was performed in all cases preoperatively. Surgical excision was performed, and EG was diagnosed on histopathology and immunohistochemistry.
  
  
  RESULTS
  There was a male predominance. Parietal bone was the most common affected bone. Total excision of the lesion was performed in all cases. No patient received postoperative radiotherapy. The follow-up period ranged from 6 months to 3 years. No tumor recurrence was noted.
  
  
  CONCLUSIONS
  With an unknown etiology, nonspecific clinical and radiological findings with diagnosis possible only on histopathological examination, EG needs to be considered in the differential diagnosis as a skull mass, especially in children.
authors: Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors: Salma
authors: S
authors: Bhat
authors: Department of Radiodiagnosis, Real Scan Imaging and Diagnostic Centre, Srinagar, Jammu and Kashmir, India.
authors: Parvez
authors: P
authors: Nazir
authors: Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors: Humaira
authors: H
authors: Bashir
authors: Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors: Ruby
authors: R
authors: Reshi
authors: Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors: Sheema
authors: S
authors: Sheikh
authors: Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors: Rohi
authors: R
authors: Wani
keywords: Eosinophilic granuloma; histiocytosis; skull