title: Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex.
abstract: BACKGROUND
  Novel taste memories, critical for animal survival, are consolidated to form long term memories which are dependent on translation regulation in the gustatory cortex (GC) hours following acquisition. However, the role of transcription regulation in the process is unknown.
  
  
  RESULTS
  Here, we report that transcription in the GC is necessary for taste learning in rats, and that drinking and its consequences, as well as the novel taste experience, affect transcription in the GC during taste memory consolidation. We show differential effects of learning on temporal dynamics in set of genes in the GC, including Arc/Arg3.1, known to regulate the homeostasis of excitatory synapses.
  
  
  CONCLUSIONS
  We demonstrate that in taste learning, transcription programs were activated following the physiological responses (i.e., fluid consumption following a water restriction regime, reward, arousal of the animal, etc.) and the specific information about a given taste (i.e., taste novelty). Moreover, the cortical differential prolonged kinetics of mRNA following novel versus familiar taste learning may represent additional novelty related molecular response, where not only the total amount, but also the temporal dynamics of transcription is modulated by sensory experience of novel information.
authors: Sagol Department of Neurobiology, Center for Gene Manipulation in the Brain, University of Haifa, Haifa, 3498838, Israel.
authors: Sharon
authors: S
authors: Inberg
authors: Sagol Department of Neurobiology, Center for Gene Manipulation in the Brain, University of Haifa, Haifa, 3498838, Israel.
authors: Eyal
authors: E
authors: Jacob
authors: Sagol Department of Neurobiology, Center for Gene Manipulation in the Brain, University of Haifa, Haifa, 3498838, Israel.
authors: Alina
authors: A
authors: Elkobi
authors: Sagol Department of Neurobiology, Center for Gene Manipulation in the Brain, University of Haifa, Haifa, 3498838, Israel.|Center for Gene Manipulation in the Brain, University of Haifa, Haifa, 3498838, Israel.
authors: Efrat
authors: E
authors: Edry
authors: Sagol Department of Neurobiology, Center for Gene Manipulation in the Brain, University of Haifa, Haifa, 3498838, Israel.
authors: Akiva
authors: A
authors: Rappaport
authors: Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh, Edinburgh, UK.|Biomathematics and Statistics Scotland, James Clerk Maxwell Building, The King's Buildings, Mayfield Road, Edinburgh, EH9 3JZ, UK.
authors: T Ian
authors: TI
authors: Simpson
authors: Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh, Edinburgh, UK.
authors: J Douglas
authors: JD
authors: Armstrong
authors: Sackler Faculty of Medicine, Bioinformatics Unit, George Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.
authors: Noam
authors: N
authors: Shomron
authors: Sackler Faculty of Medicine, Bioinformatics Unit, George Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.
authors: Metsada
authors: M
authors: Pasmanik-Chor
authors: Sagol Department of Neurobiology, Center for Gene Manipulation in the Brain, University of Haifa, Haifa, 3498838, Israel. kobir@psy.haifa.ac.il.|Center for Gene Manipulation in the Brain, University of Haifa, Haifa, 3498838, Israel. kobir@psy.haifa.ac.il.
authors: Kobi
authors: K
authors: Rosenblum
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D003213:Conditioning, Psychological; D003598:Cytoskeletal Proteins; D004327:Drinking Behavior; D005106:Exploratory Behavior; D008297:Male; D008568:Memory; D009419:Nerve Tissue Proteins; D017208:Rats, Wistar; D013649:Taste / Q000502:physiology*; D013997:Time Factors; D014158:Transcription, Genetic; D059467:Transcriptome / Q000235:genetics
chemical_list: D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; C092069:activity regulated cytoskeletal-associated protein