title: G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling.
abstract: A hallmark of G-protein-coupled receptors (GPCRs) is their ability to recognize and respond to chemically diverse ligands. Lysophospholipids constitute a relatively recent addition to these ligands and carry out their biological functions by activating G-proteins coupled to a large family of cell-surface receptors. This review aims to highlight salient features of cell signaling by one class of these receptors, known as lysophosphatidic acid (LPA) receptors, in the context of phosphatidylinositol 3-kinase (PI3K)-AKT pathway activation. LPA moieties efficiently activate AKT phosphorylation and activation in a multitude of cell types. The interplay between LPA, its receptors, the associated Gαi/o subunits, PI3K and AKT contributes to the regulation of cell survival, migration, proliferation and confers chemotherapy-resistance in certain cancers. However, detailed information on the regulation of PI3K-AKT signals induced by LPA receptors is missing from the literature. Here, some urgent issues for investigation are highlighted.
authors: Institute of Biochemistry and Biotechnology, University of the Punjab, 54590 Lahore, Pakistan. anjum.ibb@pu.edu.pk.
authors: Anjum
authors: A
authors: Riaz
authors: Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, 75123 Uppsala, Sweden. ying.huang@imbim.uu.se.
authors: Ying
authors: Y
authors: Huang
authors: Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, 75123 Uppsala, Sweden. staffan.johansson@imbim.uu.se.
authors: Staffan
authors: S
authors: Johansson
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008246:Lysophospholipids / Q000096:biosynthesis; D005810:Multigene Family; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D049368:Receptors, Lysophosphatidic Acid / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008246:Lysophospholipids; D049368:Receptors, Lysophosphatidic Acid; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; C032881:lysophosphatidic acid
keywords: AKT; G-protein coupled receptors (GPCR); PI3K; lysophosphatidic acid (LPA)