title: Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture.
abstract: Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS), which is a zoonosis endemic in eastern Asia, especially in China. The reservoir host of HTNV is field mouse (Apodemus agraricus). The main manifestation of HFRS, including acute kidney injury, increases vascular permeability, and coagulation abnormalities. In this paper, we review the current knowledge of the pathogenesis of HFRS including virus factor, immunity factor and host genetic factors. Furthermore, the treatment and prevention will be discussed.
authors: Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University Xi'an, China.
authors: Hong
authors: H
authors: Jiang
authors: Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University Xi'an, China.
authors: Hong
authors: H
authors: Du
authors: Department of Microbiology, School of Basic Medicine, Fourth Military Medical University Xi'an, China.
authors: Li M
authors: LM
authors: Wang
authors: Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University Xi'an, China.
authors: Ping Z
authors: PZ
authors: Wang
authors: Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University Xi'an, China.
authors: Xue F
authors: XF
authors: Bai
mesh_terms: D000914:Antibodies, Viral; D000998:Antiviral Agents / Q000627:therapeutic use; D001208:Asia; D042783:Endothelial Cells / Q000473:pathology / Q000821:virology; D005060:Europe; D018063:Hantaan virus / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000188:drug therapy / Q000473:pathology* / Q000635:transmission / Q000821:virology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology*; D007668:Kidney / Q000473:pathology / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents
keywords: Bunyavirus; hantaan virus; hantavirus; hemorrhagic fever with renal syndrome; pathogenesis