title: A PET/CT Directed, 3D Ultrasound-Guided Biopsy System for Prostate Cancer.
abstract: Prostate cancer affects 1 in 6 men in the USA. Systematic transrectal ultrasound (TRUS)-guided biopsy is the standard method for a definitive diagnosis of prostate cancer. However, this"blind"biopsy approach can miss at least 20% of prostate cancers. In this study, we are developing a PET/CT directed, 3D ultrasound image-guided biopsy system for improved detection of prostate cancer. In order to plan biopsy in three dimensions, we developed an automatic segmentation method based wavelet transform for 3D TRUS images of the prostate. The segmentation was tested in five patients with a DICE overlap ratio of more than 91%. In order to incorporate PET/CT images into ultrasound-guided biopsy, we developed a nonrigid registration algorithm for TRUS and PET/CT images. The registration method has been tested in a prostate phantom with a target registration error (TRE) of less than 0.4 mm. The segmentation and registration methods are two key components of the multimodality molecular image-guided biopsy system.
authors: Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30329; Winship Cancer Institute, Emory University, Atlanta, GA 30329; Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA 30329.
authors: Baowei
authors: B
authors: Fei
authors: Department of Urology, Emory University, Atlanta, GA 30329.
authors: Viraj
authors: V
authors: Master
authors: Department of Urology, Emory University, Atlanta, GA 30329.
authors: Peter
authors: P
authors: Nieh
authors: Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30329.
authors: Hamed
authors: H
authors: Akbari
authors: Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30329.
authors: Xiaofeng
authors: X
authors: Yang
authors: Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, N6A 5K8.
authors: Aaron
authors: A
authors: Fenster
authors: Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30329.
authors: David
authors: D
authors: Schuster
keywords: 3D ultrasound imaging; Molecular imaging; PET/CT; image segmentation; image-guided biopsy; nonrigid image registration; prostate cancer; wavelet transform