title: Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism.
abstract: Thyroidectomy is a surgical procedure indicated in cases of several maligned or benign thyroid diseases, thus, the aim of our study was to verify how the hypothyroidism induced by thyroidectomy influences behavioral parameters and its relation to thyroid hormones metabolism and neurogenesis at hippocampus. For this purpose, Adult male Wistar rats underwent to thyroidectomy to induce hypothyroidism. Behavioral tests, the thyroid profile and hippocampal gene expression were evaluated in control and in thyroidectomized animals. It was observed that thyroidectomized group had a significant increasing in serum thyroid-stimulating hormone (TSH) and a decreasing in thyroxine (T4) levels as well as in triiodothyronine (T3) serum level. It was also observed reduction of the monocarboxylate transporter 8 (Mct8), thyroid hormone receptor alfa (Trα1), deiodinase type 2 (Dio2), ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2) and brain-derived neurotrophic factor (Bdnf) mRNA expression in hippocampus of thyroidectomized animals. In the forced swimming test, it was verified that thyroidectomy promotes a decrease in time of immobility and climbing when compared with the control group. In summary, we demonstrated that antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism. This effect could be associated to an impaired neuronal activity in acute stress response as it is observed in forced swimming paradigm.
authors: Laboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Rodrigo Rodrigues
authors: RR
authors: da Conceição
authors: Departamento de Tecnologia de Alimentos, Instituto de Tecnologia, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil.
authors: Roberto
authors: R
authors: Laureano-Melo
authors: Laboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Kelen Carneiro
authors: KC
authors: Oliveira
authors: Laboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Maria Clara
authors: MC
authors: de Carvalho Melo
authors: Laboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Tereza Sayoko
authors: TS
authors: Kasamatsu
authors: Laboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Rui Monteiro
authors: RM
authors: de Barros Maciel
authors: Laboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Janaina Sena
authors: JS
authors: de Souza
authors: Laboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Departamento de Ciências Biológicas, Universidade Federal de São Paulo, Diadema, SP, Brazil. Electronic address: ggiannocco@gmail.com.
authors: Gisele
authors: G
authors: Giannocco
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005106:Exploratory Behavior; D005786:Gene Expression Regulation / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism*; D007037:Hypothyroidism / Q000209:etiology* / Q000473:pathology*; D007453:Iodide Peroxidase / Q000235:genetics / Q000378:metabolism; D008297:Male; D027501:Monocarboxylic Acid Transporters / Q000235:genetics / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013550:Swimming / Q000523:psychology; D013965:Thyroidectomy / Q000009:adverse effects*; D013972:Thyrotropin / Q000097:blood; D014284:Triiodothyronine / Q000378:metabolism; D000097564:Iodothyronine Deiodinase Type II; D000099189:Lysophospholipase D
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D007453:Iodide Peroxidase; D027501:Monocarboxylic Acid Transporters; D010727:Phosphoric Diester Hydrolases; D012333:RNA, Messenger; D013972:Thyrotropin; D014284:Triiodothyronine; D000097564:Iodothyronine Deiodinase Type II; D000099189:Lysophospholipase D; C478998:monocarboxylate transporter 8, rat
keywords: Brain; Depression like behavior; Hippocampus; Hypothyroidism induced by thyrodectomy