title: Barrier Function and Natural Moisturizing Factor Levels After Cumula-tive Exposure to Short-chain Aliphatic Alcohols and Detergents: Results of Occlusion-modified Tandem Repeated Irritation Test.
abstract: Alcohol-based disinfectants and detergents are common workplace factors for irritant contact dermatitis (ICD). Though occlusion and water are relevant co-exposures, the tandem effects of occlusion and sequential exposure to alcohols and detergents have not been studied. We therefore investigated the combined effects of occlusion with water and repeated exposure to n-propanol and/or sodium lauryl sulphate (SLS) in an occlusion-modified tandem irritation test. The outcomes included visual scoring, measurement of erythema, transepidermal water loss, capacitance and natural moisturizing factor (NMF) levels. Occlusion abrogated the skin barrier function and significantly enhanced the irritant-induced barrier damaging effects. The NMF levels of all irritant-exposed fields decreased significantly compared with the non-exposed fields; occlusion enhanced the decrease in NMF. Although SLS exerted more pronounced effects on the measured parameters, the barrier function impairment and NMF decrease after exposure to n-propanol in workplace-relevant concentrations, found in the study, confirm the significance of short-chain aliphatic alcohols for occupational ICD.
authors: Department of Dermatology, University of Lübeck, DE-23538 Lübeck, Germany. Irena.Angelova-Fischer@uksh.de.
authors: Irena
authors: I
authors: Angelova-Fischer
authors: Tasja
authors: T
authors: Stilla
authors: Sanja
authors: S
authors: Kezic
authors: Tobias W
authors: TW
authors: Fischer
authors: Detlef
authors: D
authors: Zillikens
mesh_terms: D000433:1-Propanol / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D017453:Dermatitis, Irritant / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D007509:Irritants / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects*; D014870:Water Loss, Insensible
chemical_list: D007509:Irritants; D012967:Sodium Dodecyl Sulfate; D000433:1-Propanol