title: Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog.
abstract: Resveratrol is a natural compound with a plethora of activities as well as limitations. We recently reported a series of resveratrol-salicylate analogs with potential chemopreventive activity. Herein, we report the anti-inflammatory and antioxidant properties of these resveratrol derivatives. Using an in vitro COX inhibition assay, and two in vivo protocols (carrageenan-induced peritonitis and paw edema), we identified a novel compound (C10) as a potent anti-inflammatory agent. The enhanced potency of C10 was associated with the ability of C10 to decrease the activity of myeloperoxidase (MPO) enzyme at 10mg/kg, whereas resveratrol and it's natural analog (TMS) did not exert the same effect. Additionally, C10 significantly reduced the concentration of intracellular reactive oxygen species. Because of the proven association between cancer, inflammation, and oxidative stress, we believe that C10 is a promising chemopreventive molecule.
authors: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada. Electronic address: aldawsar@ualberta.ca.
authors: Fahad S
authors: FS
authors: Aldawsari
authors: Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR 870020-900, Brazil.
authors: Rafael Pazinatto
authors: RP
authors: Aguiar
authors: Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR 870020-900, Brazil.
authors: Luiz Alexandre Marques
authors: LA
authors: Wiirzler
authors: Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, México City, DF 04510, Mexico.
authors: Rodrigo
authors: R
authors: Aguayo-Ortiz
authors: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Madinah, Saudi Arabia.
authors: Naif
authors: N
authors: Aljuhani
authors: Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR 870020-900, Brazil.
authors: Roberto Kenji Nakamura
authors: RK
authors: Cuman
authors: Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, México City, DF 04510, Mexico.
authors: José L
authors: JL
authors: Medina-Franco
authors: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
authors: Arno G
authors: AG
authors: Siraki
authors: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
authors: Carlos A
authors: CA
authors: Velázquez-Martínez
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002351:Carrageenan; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy*; D056945:Hep G2 Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D010538:Peritonitis / Q000188:drug therapy*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D012459:Salicylates / Q000737:chemistry / Q000494:pharmacology*; D013267:Stilbenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D016861:Cyclooxygenase Inhibitors; D017382:Reactive Oxygen Species; D012459:Salicylates; D013267:Stilbenes; D002351:Carrageenan; D006861:Hydrogen Peroxide; D011451:Prostaglandin-Endoperoxide Synthases; D000077185:Resveratrol
keywords: Chemoprevention; Inflammation; Myeloperoxidase; Resveratrol; Salicylate