title: DNA-Guided Precision Medicine for Cancer: A Case of Irrational Exuberance?
abstract: Precision treatment with targeted cancer drugs requires the selection of patients who are most likely to benefit from a given therapy. We argue here that the use of a combination of both DNA and transcriptome analyses will significantly improve drug response prediction.
authors: Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
authors: Emile E
authors: EE
authors: Voest
authors: Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands. r.bernards@nki.nl.
authors: Rene
authors: R
authors: Bernards
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D058990:Molecular Targeted Therapy; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D018579:Patient Selection; D057285:Precision Medicine; D017422:Sequence Analysis, DNA; D017423:Sequence Analysis, RNA; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents