title: Association between IL-27 2905T/G genotypes and the risk and survival of cervical cancer: a case-control study.
abstract: BACKGROUND
  Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties.
  
  
  METHODS
  A case-control study was conducted to investigate the possible associations of IL-27 gene polymorphisms with susceptibility to cervical cancer and clinical outcome.
  
  
  RESULTS
  Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer. Further analysis showed IL-27 2905T/G genotypes were associated with advanced tumor stages of cervical cancer patients. More interestingly, the IL-27 2905T/G genotypes were statistically significantly associated with the survival in cervical cancer patients.
  
  
  CONCLUSIONS
  Our results showed that the IL-27 2905T/G genotypes were associated with decreased the susceptibility and development of cervical cancer in Chinese Han population.
authors: a Department of Internal Medicine-Oncology , the First Affiliated Hospital of Xi 'an Jiaotong University , Shaanxi , China .|b Department of Gynecologic Tumor and.
authors: Guo-Qing
authors: GQ
authors: Wang
authors: c Department of Anesthesiology , Shaanxi Province Tumor Hospital , Shaanxi , China.
authors: Wen-Hui
authors: WH
authors: Zhao
authors: b Department of Gynecologic Tumor and.
authors: Xi-Xia
authors: XX
authors: Zhao
authors: b Department of Gynecologic Tumor and.
authors: Jun
authors: J
authors: Zhang
authors: a Department of Internal Medicine-Oncology , the First Affiliated Hospital of Xi 'an Jiaotong University , Shaanxi , China .
authors: Ke-Jun
authors: KJ
authors: Nan
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D007378:Interleukins; C464565:MYDGF protein, human
keywords: Cervical cancer; IL-27; single-nucleotide polymorphism; susceptibility