title: Behçet's disease physiopathology: a contemporary review.
abstract: Behçet's disease, also known as the Silk Road Disease, is a rare systemic vasculitis disorder of unknown etiology. Recurrent attacks of acute inflammation characterize Behçet's disease. Frequent oral aphthous ulcers, genital ulcers, skin lesions and ocular lesions are the most common manifestations. Inflammation is typically self-limiting in time and relapsing episodes of clinical manifestations represent a hallmark of Behçet's disease. Other less frequent yet severe manifestations that have a major prognostic impact involve the eyes, the central nervous system, the main large vessels and the gastrointestinal tract. Behçet's disease has a heterogeneous onset and is associated with significant morbidity and premature mortality. This study presents a current immunological review of the disease and provides a synopsis of clinical aspects and treatment options.
authors: Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, 75005, Paris, France.|INSERM, UMR_S 959, 75013, Paris, France.|CNRS, FRE3632, 75005, Paris, France.
authors: Mohamad J
authors: MJ
authors: Zeidan
authors: Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, 75005, Paris, France.|INSERM, UMR_S 959, 75013, Paris, France.|CNRS, FRE3632, 75005, Paris, France.|Department of Internal Medicine and Clinical Immunology, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, 83 Boulevard de l'Hôpital, 75013, Paris, France.
authors: David
authors: D
authors: Saadoun
authors: Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, 75005, Paris, France.|INSERM, UMR_S 959, 75013, Paris, France.|CNRS, FRE3632, 75005, Paris, France.
authors: Marlene
authors: M
authors: Garrido
authors: Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, 75005, Paris, France.|INSERM, UMR_S 959, 75013, Paris, France.|CNRS, FRE3632, 75005, Paris, France.
authors: David
authors: D
authors: Klatzmann
authors: Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, 75005, Paris, France.|INSERM, UMR_S 959, 75013, Paris, France.|CNRS, FRE3632, 75005, Paris, France.
authors: Adrien
authors: A
authors: Six
authors: Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, 75005, Paris, France. patrice.cacoub@psl.aphp.fr.|INSERM, UMR_S 959, 75013, Paris, France. patrice.cacoub@psl.aphp.fr.|CNRS, FRE3632, 75005, Paris, France. patrice.cacoub@psl.aphp.fr.|Department of Internal Medicine and Clinical Immunology, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, 83 Boulevard de l'Hôpital, 75013, Paris, France. patrice.cacoub@psl.aphp.fr.
authors: Patrice
authors: P
authors: Cacoub
keywords: Autoimmunity; Behçet disease; Inflammation; Physiopathology