title: Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses.
abstract: Persistent viral infections are widespread and represent significant public health burdens. Some viruses endure in a latent state by co-opting the host epigenetic machinery to manipulate viral gene expression. Small molecules targeting epigenetic pathways are now in the clinic for certain cancers and are considered as potential treatment strategies to reverse latency in HIV-infected individuals. In this review, we discuss how drugs interfering with one epigenetic pathway, protein acetylation, perturb latency of three families of pathogenic human viruses-retroviruses, herpesviruses, and papillomaviruses.
authors: Gladstone Institute of Virology and Immunology , San Francisco, California 94158, United States.|Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California , San Francisco, California 94158, United States.|Department of Medicine, University of California , San Francisco, California 94158, United States.
authors: Ryan J
authors: RJ
authors: Conrad
authors: Gladstone Institute of Virology and Immunology , San Francisco, California 94158, United States.|Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California , San Francisco, California 94158, United States.|Department of Medicine, University of California , San Francisco, California 94158, United States.
authors: Melanie
authors: M
authors: Ott
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D017735:Virus Latency / Q000502:physiology*
chemical_list: D000998:Antiviral Agents