title: Kingella kingae-Associated Pediatric Osteoarticular Infections: An Overview of 566 Reported Cases.
abstract: This study aimed to summarize clinical experience with Kingella kingae-associated pediatric osteoarticular infections (OAIs). We reviewed 566 cases in the English literature from 2000 to June 2014. More than 80% of the patients were diagnosed between 4 months and 4 years of age, and the male to female ratio was 1.14:1. The most frequent preceding illness was upper respiratory tract infections (82%). The top 3 OAIs types were septic arthritis (73.1%), osteomyelitis (15.7%), and spondylodiscitis (5.4%), and the most affected sites of these types were knee (46%), calcaneus (20%), and L4/5 disc (70%). All cases where polymerase chain reaction (PCR) technique was used were PCR positive, no reported cases of positive cultures for K kingae with negative PCR. The duration of antibiotics use ranged from 2 to 4 weeks. Beta-lactam antibiotics were the most frequently used intravenously and orally. The clinical efficacy was favorable.
authors: 1 Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
authors: Mohammed
authors: M
authors: Al-Qwbani
authors: 1 Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
authors: Nan
authors: N
authors: Jiang
authors: 1 Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
authors: Bin
authors: B
authors: Yu
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001850:Bone Diseases, Infectious / Q000188:drug therapy / Q000453:epidemiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007592:Joint Diseases / Q000188:drug therapy / Q000453:epidemiology*; D017882:Kingella kingae; D008297:Male; D016870:Neisseriaceae Infections / Q000188:drug therapy* / Q000453:epidemiology*; D016133:Polymerase Chain Reaction
chemical_list: D000900:Anti-Bacterial Agents
keywords: Kingella kingae; arthritis; osteomyelitis; pediatric osteoarticular infection; retrospective analysis; spondylodiscitis