title: XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning.
abstract: Childhood lead (Pb) poisoning remains a global issue, especially in industrial areas. In this study, 115 children with average age 5.7 years were recruited as either patient diagnosed with Pb poisoning or controls at Xinhua Hospital in China. The subjects' bone Pb was measured with a K-shell X-ray fluorescence (KXRF) and a portable X-ray fluorescence (XRF) system. A significant correlation between KXRF bone Pb and blood Pb and portable XRF and KXRF measurements were observed. The half-life of blood-lead was calculated to be 9.96 ± 3.92 d. Our results indicate that bone is a useful biomarker for Pb in children.
authors: a School of Health Sciences , Purdue University , West Lafayette, IN , USA .
authors: Aaron J
authors: AJ
authors: Specht
authors: b Xinhua Hospital, MOE-Shanghai Key Laboratory of Children's Environmental Health, Department of Child and Adolescent Healthcare , Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine , Shanghai , China .
authors: Yanfen
authors: Y
authors: Lin
authors: c Harvard School of Public Health , Boston, MA , USA , and.
authors: Marc
authors: M
authors: Weisskopf
authors: b Xinhua Hospital, MOE-Shanghai Key Laboratory of Children's Environmental Health, Department of Child and Adolescent Healthcare , Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine , Shanghai , China .
authors: Chonghuai
authors: C
authors: Yan
authors: d Dalla Lana School of Public Health , University of Toronto , Toronto, ON , Canada.
authors: Howard
authors: H
authors: Hu
authors: b Xinhua Hospital, MOE-Shanghai Key Laboratory of Children's Environmental Health, Department of Child and Adolescent Healthcare , Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine , Shanghai , China .
authors: Jian
authors: J
authors: Xu
authors: a School of Health Sciences , Purdue University , West Lafayette, IN , USA .
authors: Linda H
authors: LH
authors: Nie
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D001842:Bone and Bones / Q000737:chemistry*; D002648:Child; D002675:Child, Preschool; D002681:China; D004781:Environmental Exposure; D006801:Humans; D007854:Lead / Q000032:analysis* / Q000493:pharmacokinetics; D007855:Lead Poisoning / Q000175:diagnosis*; D013052:Spectrometry, X-Ray Emission / Q000379:methods*
chemical_list: D015415:Biomarkers; D007854:Lead
keywords: In vivo; X-ray fluorescence; portable