title: A WUR SNP is associated with European Porcine Reproductive and Respiratory Virus Syndrome resistance and growth performance in pigs.
abstract: Porcine reproductive and respiratory syndrome (PRRS) causes decreased reproductive performance and respiratory problems in pigs. The goals of the current study were 1) to examine whether individual variation applies to infection with PRRSV European strains and 2) to investigate the association of a single nucleotide polymorphism (SNP) WUR10000125 (WUR) at the interferon-inducible guanylate-binding protein 1 gene (GBP1) with average daily gain (ADG) in PRRSV infected and uninfected pigs. The experimental procedure consisted of two trials in which pigs from negative PRRSV farms were infected with a wild-type (n=80) or vaccinated with an attenuated European PRRS virus strain (n=40) and then monitored after infection or vaccination. Viral load and ADG were determined for each pig. In a third trial, the ADG for PRRSV-free pigs was monitored. All pigs were genotyped for WUR at the GBP1 gene (AA and AG genotype were defined). Results indicated that there was individual variation in the viral load from pigs challenged with a wild-type or low virulent European PRRSV strain. Secondly, our data showed that WUR SNP was associated to ADG in vaccinated pigs. Thus, ADG in AG pigs was significantly higher than in AA ones after vaccinating with an attenuated PRRSV strain. However, the reverse happened in a PRRSV-free environment where the AA pigs were those that grew faster. Based on these results, there is a scope for selecting pigs according to their responses to PRRS virus infection with European strains and that WUR SNP may play a role in causing PRRSV resistance.
authors: Departament de Producció Animal, ETSEA, University of Lleida-Agrotecnio, 25198 Lleida, Spain; Pinsos del Segre SA, 25600 Balaguer, Spain.
authors: Glòria
authors: G
authors: Abella
authors: Departament de Producció Animal, ETSEA, University of Lleida-Agrotecnio, 25198 Lleida, Spain.
authors: Ramona N
authors: RN
authors: Pena
authors: Departament de Producció Animal, ETSEA, University of Lleida-Agrotecnio, 25198 Lleida, Spain.
authors: Carmina
authors: C
authors: Nogareda
authors: Departament de Producció Animal, ETSEA, University of Lleida-Agrotecnio, 25198 Lleida, Spain.
authors: Ramón
authors: R
authors: Armengol
authors: Vall Companys group, 25191 Lleida, Spain.
authors: Albert
authors: A
authors: Vidal
authors: Vall Companys group, 25191 Lleida, Spain.
authors: Luis
authors: L
authors: Moradell
authors: Group de Sanejament Porcí, 25192 Lleida, Spain.
authors: Vicens
authors: V
authors: Tarancon
authors: Group de Sanejament Porcí, 25192 Lleida, Spain.
authors: Elena
authors: E
authors: Novell
authors: Departament de Producció Animal, ETSEA, University of Lleida-Agrotecnio, 25198 Lleida, Spain.
authors: Joan
authors: J
authors: Estany
authors: Departament de Producció Animal, ETSEA, University of Lleida-Agrotecnio, 25198 Lleida, Spain. Electronic address: lorenzo.fraile@prodan.udl.cat.
authors: Lorenzo
authors: L
authors: Fraile
mesh_terms: D000818:Animals; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D019318:Porcine Reproductive and Respiratory Syndrome / Q000235:genetics* / Q000821:virology; D019316:Porcine respiratory and reproductive syndrome virus / Q000502:physiology*; D013552:Swine / Q000254:growth & development; D015430:Weight Gain
chemical_list: D019204:GTP-Binding Proteins
keywords: Genetic resistance; PRRSV; Piglets; SNP; Variation