title: Drug-drug co-crystallization presents a new opportunity for the development of stable vitamins.
abstract: Drug-drug co-crystallization could realize combination drugs at a molecular level. Two polymorphic co-crystals between VD2 and VD3 were successfully designed and synthesized. These enantiotropic polymorphs exhibit significantly different physicochemical stabilities.
authors: Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. xuefengmei@simm.ac.cn.
authors: Jian-Rong
authors: JR
authors: Wang
authors: Qihui
authors: Q
authors: Yu
authors: Wenjuan
authors: W
authors: Dai
authors: Xuefeng
authors: X
authors: Mei
mesh_terms: D002762:Cholecalciferol / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003460:Crystallization; D004872:Ergocalciferols / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D033362:Powder Diffraction; D013818:Thermogravimetry
chemical_list: D004872:Ergocalciferols; D004364:Pharmaceutical Preparations; D002762:Cholecalciferol