title: Burden of disease of dietary exposure to acrylamide in Denmark.
abstract: Acrylamide (AA) is a process-contaminant that potentially increases the risk of developing cancer in humans. AA is formed during heat treatment of starchy foods and detected in a wide range of commonly consumed products. Increased focus on risk ranking and prioritization of major causes of disease makes it relevant to estimate the impact that exposure to chemical contaminants and other hazards in food have on health. In this study, we estimated the burden of disease (BoD) caused by dietary exposure to AA, using disability adjusted life years (DALY) as health metric. We applied an exposure-based approach and proposed a model of three components: an exposure, health-outcome, and DALY-module. We estimated BoD using two approaches for estimating cancer risk based on toxicological data and two approaches for estimating DALY. In Denmark, 1.8 healthy life years per 100.000 inhabitants are lost each year due to exposure to AA through foods, as estimated by the most conservative approach. This result should be used to inform risk management decisions and for comparison with BoD of other food-borne hazards for prioritizing policies. However, our study shows that careful evaluation of methodological choices and assumptions used in BoD studies is necessary before use in policy making.
authors: Division for Diet, Disease Prevention and Toxicology, The National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 Søborg, Denmark. Electronic address: leaja@food.dtu.dk.
authors: Lea Sletting
authors: LS
authors: Jakobsen
authors: Division for Food Technology, The National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 Søborg, Denmark.
authors: Kit
authors: K
authors: Granby
authors: Division for Diet, Disease Prevention and Toxicology, The National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 Søborg, Denmark.
authors: Vibeke Kildegaard
authors: VK
authors: Knudsen
authors: Division for Diet, Disease Prevention and Toxicology, The National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 Søborg, Denmark.
authors: Maarten
authors: M
authors: Nauta
authors: Division for Diet, Disease Prevention and Toxicology, The National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 Søborg, Denmark.
authors: Sara Monteiro
authors: SM
authors: Pires
authors: Division for Diet, Disease Prevention and Toxicology, The National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 Søborg, Denmark. Electronic address: morp@food.dtu.dk.
authors: Morten
authors: M
authors: Poulsen
mesh_terms: D020106:Acrylamide / Q000737:chemistry / Q000633:toxicity*; D002273:Carcinogens / Q000737:chemistry; D017281:Cost of Illness; D003718:Denmark; D004781:Environmental Exposure / Q000032:analysis; D005506:Food Contamination; D006801:Humans; D008954:Models, Biological; D018570:Risk Assessment
chemical_list: D002273:Carcinogens; D020106:Acrylamide
keywords: Acrylamide; Cancer; DALY