title: Classification of vocal fold leukoplakia by clinical scoring.
abstract: Vocal cord leukoplakia comprises a variety of lesions. The purpose of this study was to stratify vocal leukoplakias before surgery.
  
  
  
  Patients with an initial diagnosis of vocal leukoplakia who underwent surgical excision at a tertiary referral center in Taiwan were recruited for this study. Their clinical records, including age, sex, preoperative laryngoscopic images in the office setting, and final pathology reports were collected and analyzed.
  
  
  
  Patient age (p = .010), nonhomogenous lesion texture (p = .001), and existence of hyperemia (p = .014) were identified as independent factors predicting malignancy. A predictive formula was established accordingly. The model showed an excellent discrimination role by receiver operating characteristic curve analysis (area under the curve = 0.86; p < .001).
  
  
  
  This study confirmed the value of a scoring system based on laryngoscopic characteristics and patient age for predicting the histologic results in vocal leukoplakia. It is helpful for classifying vocal leukoplakia and pretreatment planning. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1998-E2003, 2016.
authors: Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.|School of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors: Tuan-Jen
authors: TJ
authors: Fang
authors: Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.|School of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors: Wan-Ni
authors: WN
authors: Lin
authors: School of Medicine, Chang Gung University, Taoyuan, Taiwan.|Department of Pathology, Chang Gung Memorial Hospital, Linkou, Taiwan.
authors: Li-Yu
authors: LY
authors: Lee
authors: Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors: Chi-Kuang
authors: CK
authors: Young
authors: Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.|School of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors: Li-Ang
authors: LA
authors: Lee
authors: Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.|School of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors: Kai-Ping
authors: KP
authors: Chang
authors: Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.|School of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors: Chun-Ta
authors: CT
authors: Liao
authors: Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.|School of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors: Hseuh-Yu
authors: HY
authors: Li
authors: School of Medicine, Chang Gung University, Taoyuan, Taiwan.|Department of Nuclear Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
authors: Tzu-Chen
authors: TC
authors: Yen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000145:classification* / Q000473:pathology; D007828:Laryngoscopy; D007971:Leukoplakia / Q000145:classification* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D013624:Taiwan; D014827:Vocal Cords / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: dysphonia; laryngoscopy; larynx; scoring; vocal leukoplakia