title: Discriminatory value of carotid artery elasticity changes for the evaluation of thyroid dysfunction in patients with hashimoto's thyroiditis.
abstract: OBJECTIVE
  To evaluate the discriminatory value of carotid artery wall thickness and elasticity for thyroid dysfunction in Hashimoto's thyroiditis (HT) patients.
  
  
  METHODS
  A total of 180 female HT patients were assigned to three groups on the basis of laboratory testing: HT hyperthyroidism group (group A), HT hypothyroidism group (group B), and HT euthyroid group (group C). We used radiofrequency sonographic signal analysis for the measurement of intima-media thickness and arterial stiffness.
  
  
  RESULTS
  Intima-media thickness was significantly higher in group A than in other groups. After stepwise variable selection, distensibility coefficient (DC), compliance coefficient, stiffness index (β), and pulse wave velocity (PWV) were selected to discriminate different thyroid hormone levels, resulting in the following discriminant function: Z1 = -0.398DC + 0.803PWV. The receiver-operator characteristic curve analysis showed that the critical points were DC = 0.022 kPa(-1) and PWV = 5.36 m/s for HT hyperthyroidism, and DC = 0.016 kPa(-1) and PWV = 6.875 m/s for HT hypothyroidism.
  
  
  CONCLUSIONS
  DC and PWV may be useful for the evaluation of thyroid function in HT patients. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 44:298-304, 2016.
authors: Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, 710004, China.
authors: Xiaolei
authors: X
authors: Feng
authors: Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, 710004, China.
authors: Linlin
authors: L
authors: Zhao
authors: Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, 710004, China.
authors: Jue
authors: J
authors: Jiang
authors: Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, 710004, China.
authors: Wenqi
authors: W
authors: Ma
authors: Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, 710004, China.
authors: Xue
authors: X
authors: Shang
authors: Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, 710004, China.
authors: Qi
authors: Q
authors: Zhou
authors: Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, 710004, China.
authors: Hongli
authors: H
authors: Zhang
authors: Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, 710004, China.
authors: Shanshan
authors: S
authors: Yu
authors: Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, 710004, China.
authors: Yanhua
authors: Y
authors: Qi
mesh_terms: D000328:Adult; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D005260:Female; D050031:Hashimoto Disease / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D013961:Thyroid Gland / Q000503:physiopathology*; D014463:Ultrasonography; D059289:Vascular Stiffness / Q000502:physiology*
keywords: Hashimoto's thyroiditis; IMT; arterial wall; carotid artery; elasticity; hyperthyroidism; radiofrequency analysis; ultrasound