title: MicroRNAs in the Host-Apicomplexan Parasites Interactions: A Review of Immunopathological Aspects.
abstract: MicroRNAs (miRNAs), a class of small non-coding regulatory RNAs, have been detected in a variety of organisms ranging from ancient unicellular eukaryotes to mammals. They have been associated with numerous molecular mechanisms involving developmental, physiological and pathological changes of cells and tissues. Despite the fact that miRNA-silencing mechanisms appear to be absent in some Apicomplexan species, an increasing number of studies have reported a role for miRNAs in host-parasite interactions. Host miRNA expression can change following parasite infection and the consequences can lead, for instance, to parasite clearance. In this context, the immune system signaling appears to have a crucial role.
authors: Laboratory of Tropical Diseases, Department of Genetics, Evolution and Bioagents, University of Campinas UNICAMP, Campinas, Brazil.
authors: Carla C
authors: CC
authors: Judice
authors: Laboratory of Tropical Diseases, Department of Genetics, Evolution and Bioagents, University of Campinas UNICAMP, Campinas, Brazil.
authors: Catarina
authors: C
authors: Bourgard
authors: Laboratory of Tropical Diseases, Department of Genetics, Evolution and Bioagents, University of Campinas UNICAMP, Campinas, Brazil.
authors: Ana C A V
authors: AC
authors: Kayano
authors: Instituto Carlos Chagas, Fiocruz-Paraná Curitiba, Brazil.
authors: Letusa
authors: L
authors: Albrecht
authors: Laboratory of Tropical Diseases, Department of Genetics, Evolution and Bioagents, University of Campinas UNICAMP, Campinas, Brazil.
authors: Fabio T M
authors: FT
authors: Costa
mesh_terms: D003457:Cryptosporidiosis / Q000276:immunology / Q000382:microbiology; D003458:Cryptosporidium / Q000276:immunology*; D005786:Gene Expression Regulation / Q000235:genetics / Q000276:immunology*; D006790:Host-Parasite Interactions / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008288:Malaria / Q000276:immunology / Q000382:microbiology; D035683:MicroRNAs / Q000235:genetics*; D010961:Plasmodium / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000276:immunology / Q000382:microbiology
chemical_list: D035683:MicroRNAs
keywords: Apicomplexa; cell host; immune response; microRNA; parasites