title: Measurement, Interpretation and Use of Free Ligand Solution Conformations in Drug Discovery.
authors: C4X Discovery Ltd, Manchester One, Manchester, United Kingdom.
authors: Charles D
authors: CD
authors: Blundell
authors: C4X Discovery Ltd, Manchester One, Manchester, United Kingdom.
authors: Thorsten
authors: T
authors: Nowak
authors: C4X Discovery Ltd, Manchester One, Manchester, United Kingdom.
authors: Martin J
authors: MJ
authors: Watson
mesh_terms: D055808:Drug Discovery; D006860:Hydrogen Bonding; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012996:Solutions
chemical_list: D008024:Ligands; D012996:Solutions
keywords: Cambridge Structural Database; Conformation; Conformational analysis; Conformational design; Conformational preference; Conformational selection; Conformer; Conformetrics; Ligand-based drug design; Nuclear magnetic resonance; Protein Data Bank; Rational drug design; Stereoelectronic effect; Torsional preferences