title: Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis.
abstract: Single nucleotide polymorphisms (SNPs) in the interleukin-17 (IL-17) gene have been shown to be correlated with susceptibility to cancer. However, various studies report different results of this association. The aim of the present work was to clarify the effects of IL-17A G197A (rs2275913) and IL-17F T7488C (rs763780) polymorphisms on cancer risk. We performed systematic searches of the PubMed and CNKI databases to obtain relevant publications. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association of rs2275913 and rs763780 polymorphisms with cancer risk. Data were extracted from the selected studies, and statistical analysis was conducted using the STATA software. Our results indicated that rs2275913 and rs763780 polymorphisms significantly increase cancer risk, especially in gastric cancers. Subgroup analysis suggested the existence of a significant correlation between rs763780 polymorphism and cancer susceptibility in Caucasian populations. This updated meta-analysis confirms that rs2275913 and rs763780 polymorphisms are highly associated with increased risk for multiple forms of cancer.
authors: Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.|Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Zhi-Ming
authors: ZM
authors: Dai
authors: Department Of TCM, The Jing'an District Center Hospital of Shanghai, Shanghai 200040, China.
authors: Tian-Song
authors: TS
authors: Zhang
authors: Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Shuai
authors: S
authors: Lin
authors: Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Wang-Gang
authors: WG
authors: Zhang
authors: Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Jie
authors: J
authors: Liu
authors: Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Xing-Mei
authors: XM
authors: Cao
authors: Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors: Hong-Bao
authors: HB
authors: Li
authors: Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Meng
authors: M
authors: Wang
authors: Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Xing-Han
authors: XH
authors: Liu
authors: Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Kang
authors: K
authors: Liu
authors: Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Shan-Li
authors: SL
authors: Li
authors: Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Zhi-Jun
authors: ZJ
authors: Dai
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17