title: Optical fiber-based full Mueller polarimeter for endoscopic imaging using a two-wavelength simultaneous measurement method.
abstract: This paper reports a technique based on spectrally differential measurement for determining the full Mueller matrix of a biological sample through an optical fiber. In this technique, two close wavelengths were used simultaneously, one for characterizing the fiber and the other for characterizing the assembly of fiber and sample. The characteristics of the fiber measured at one wavelength were used to decouple its contribution from the measurement on the assembly of fiber and sample and then to extract sample Mueller matrix at the second wavelength. The proof of concept was experimentally validated by measuring polarimetric parameters of various calibrated optical components through the optical fiber. Then, polarimetric images of histological cuts of human colon tissues were measured, and retardance, diattenuation, and orientation of the main axes of fibrillar regions were displayed. Finally, these images were successfully compared with images obtained by a free space Mueller microscope. As the reported method does not use any moving component, it offers attractive integration possibilities with an endoscopic probe.
authors: University of Limoges, CNRS, Xlim Institute, UMR 7252, 123 Avenue A. Thomas, F-87000 Limoges, France.
authors: Jérémy
authors: J
authors: Vizet
authors: University of Limoges, CNRS, Xlim Institute, UMR 7252, 123 Avenue A. Thomas, F-87000 Limoges, FrancebUniversité Paris Saclay, LPICM, CNRS, Ecole Polytechnique, 91128 Palaiseau, France.
authors: Sandeep
authors: S
authors: Manhas
authors: Université Paris Saclay, LPICM, CNRS, Ecole Polytechnique, 91128 Palaiseau, France.
authors: Jacqueline
authors: J
authors: Tran
authors: Institut Mutualiste Montsouris, Département d'anatomopathologie, 42 Boulevard Jourdan F-75014 Paris, France.
authors: Pierre
authors: P
authors: Validire
authors: Institut Mutualiste Montsouris, Département d'anatomopathologie, 42 Boulevard Jourdan F-75014 Paris, France.
authors: Abdelali
authors: A
authors: Benali
authors: Université Paris Saclay, LPICM, CNRS, Ecole Polytechnique, 91128 Palaiseau, France.
authors: Enric
authors: E
authors: Garcia-Caurel
authors: Université Paris Saclay, LPICM, CNRS, Ecole Polytechnique, 91128 Palaiseau, France.
authors: Angelo
authors: A
authors: Pierangelo
authors: Université Paris Saclay, LPICM, CNRS, Ecole Polytechnique, 91128 Palaiseau, France.
authors: Antonello
authors: A
authors: De Martino
authors: University of Limoges, CNRS, Xlim Institute, UMR 7252, 123 Avenue A. Thomas, F-87000 Limoges, France.
authors: Dominique
authors: D
authors: Pagnoux
mesh_terms: D003106:Colon / Q000033:anatomy & histology / Q000737:chemistry; D004724:Endoscopy / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D055100:Optical Fibers; D061848:Optical Imaging / Q000295:instrumentation* / Q000379:methods*