title: The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility.
abstract: As of late, polyphenols have increasingly interested the scientific community due to their proposed health benefits. Much of this attention has focused on their bioavailability. Polyphenol-gut microbiota interactions should be considered to understand their biological functions. The dichotomy between the biotransformation of polyphenols into their metabolites by gut microbiota and the modulation of gut microbiota composition by polyphenols contributes to positive health outcomes. Although there are many studies on the in vivo bioavailability of polyphenols, the mutual relationship between polyphenols and gut microbiota is not fully understood. This review focuses on the biotransformation of polyphenols by gut microbiota, modulation of gut microbiota by polyphenols, and the effects of these two-way mutual interactions on polyphenol bioavailability, and ultimately, human health.
authors: Department of Food Engineering, Faculty of Engineering and Architecture, Okan Univesity, Tuzla, Istanbul TR-34959, Turkey. tugba.ozdal@okan.edu.tr.
authors: Tugba
authors: T
authors: Ozdal
authors: Department of Food Science, University of Massachusetts Amherst, Amherst, MA 01003, USA. davidsela@umass.edu.
authors: David A
authors: DA
authors: Sela
authors: Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Taipa, Macau, China. jianboxiao@umac.mo.
authors: Jianbo
authors: J
authors: Xiao
authors: Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul TR-34469, Turkey. boyaci@itu.edu.tr.
authors: Dilek
authors: D
authors: Boyacioglu
authors: College of Food Science and Nutritional Engineering, National Engineering Research Centre for Fruits and Vegetables Processing, China Agricultural University, Beijing 100083, China. chenfangch@sina.com.
authors: Fang
authors: F
authors: Chen
authors: Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul TR-34469, Turkey. capanogl@itu.edu.tr.
authors: Esra
authors: E
authors: Capanoglu
mesh_terms: D001682:Biological Availability; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006801:Humans; D059808:Polyphenols / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D059808:Polyphenols
keywords: bioavailability; flavonoids; gut microbiota; health; interactions; microbial metabolism; phenolics; polyphenols