title: Outstanding drug loading capacity by water stable microporous MOF: a potential drug carrier.
abstract: A robust, highly water stable (up to 3 weeks), microporous MOF, [Zn8(O)2(CDDB)6(DMF)4(H2O)] {where CDDB = 4,4'-(9-H carbazole-3,6-diyl)dibenzoic acid}, was synthesized based on an open N-H site by a solvothermal process and exhibited an outstanding loading capacity (around 53.3 wt%) and satisfactory release capability (64.9% and 81.9%) for 5-fluorouracil, constituting a negligible cytotoxicity effect.
authors: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, Fujian, P. R. China. rcao@fjirsm.ac.cn.
authors: Partha Pratim
authors: PP
authors: Bag
authors: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, Fujian, P. R. China. rcao@fjirsm.ac.cn and Fujian Normal University, Fuzhou, Fujian 350117, China.
authors: Dong
authors: D
authors: Wang
authors: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, Fujian, P. R. China. rcao@fjirsm.ac.cn.
authors: Zhuo
authors: Z
authors: Chen
authors: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, Fujian, P. R. China. rcao@fjirsm.ac.cn.
authors: Rong
authors: R
authors: Cao
mesh_terms: D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry*; D004337:Drug Carriers; D005472:Fluorouracil / Q000737:chemistry*; D008958:Models, Molecular; D014867:Water; D015032:Zinc / Q000737:chemistry*
chemical_list: D002227:Carbazoles; D056831:Coordination Complexes; D004337:Drug Carriers; D014867:Water; D015032:Zinc; D005472:Fluorouracil