title: Three-dimensional morphology study of surgical adolescent idiopathic scoliosis patient from encoded geometric models.
abstract: The classification of three-dimensional (3D) spinal deformities remains an open question in adolescent idiopathic scoliosis. Recent studies have investigated pattern classification based on explicit clinical parameters. An emerging trend however seeks to simplify complex spine geometries and capture the predominant modes of variability of the deformation. The objective of this study is to perform a 3D characterization and morphology analysis of the thoracic and thoraco/lumbar scoliotic spines (cross-sectional study). The presence of subgroups within all Lenke types will be investigated by analyzing a simplified representation of the geometric 3D reconstruction of a patient's spine, and to establish the basis for a new classification approach based on a machine learning algorithm.
  
  
  
  Three-dimensional reconstructions of coronal and sagittal standing radiographs of 663 patients, for a total of 915 visits, covering all types of deformities in adolescent idiopathic scoliosis (single, double and triple curves) and reviewed by the 3D Classification Committee of the Scoliosis Research Society, were analyzed using a machine learning algorithm based on stacked auto-encoders. The codes produced for each 3D reconstruction would be then grouped together using an unsupervised clustering method. For each identified cluster, Cobb angle and orientation of the plane of maximum curvature in the thoracic and lumbar curves, axial rotation of the apical vertebrae, kyphosis (T4-T12), lordosis (L1-S1) and pelvic incidence were obtained. No assumptions were made regarding grouping tendencies in the data nor were the number of clusters predefined.
  
  
  
  Eleven groups were revealed from the 915 visits, wherein the location of the main curve, kyphosis and lordosis were the three major discriminating factors with slight overlap between groups. Two main groups emerge among the eleven different clusters of patients: a first with small thoracic deformities and large lumbar deformities, while the other with large thoracic deformities and small lumbar curvature. The main factor that allowed identifying eleven distinct subgroups within the surgical patients (major curves) from Lenke type-1 to type-6 curves, was the location of the apical vertebra as identified by the planes of maximum curvature obtained in both thoracic and thoraco/lumbar segments. Both hypokyphotic and hyperkypothic clusters were primarily composed of Lenke 1-4 curve type patients, while a hyperlordotic cluster was composed of Lenke 5 and 6 curve type patients.
  
  
  
  The stacked auto-encoder analysis technique helped to simplify the complex nature of 3D spine models, while preserving the intrinsic properties that are typically measured with explicit parameters derived from the 3D reconstruction.
authors: Polytechnique Montréal, P.O. Box 6079, Succursale Centre-ville, Montreal, QC, H3C 3A7, Canada.|Sainte-Justine University Hospital Centre, 3175 Cote-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
authors: William
authors: W
authors: Thong
authors: Sainte-Justine University Hospital Centre, 3175 Cote-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
authors: Stefan
authors: S
authors: Parent
authors: Sainte-Justine University Hospital Centre, 3175 Cote-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
authors: James
authors: J
authors: Wu
authors: Polytechnique Montréal, P.O. Box 6079, Succursale Centre-ville, Montreal, QC, H3C 3A7, Canada.|Sainte-Justine University Hospital Centre, 3175 Cote-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
authors: Carl-Eric
authors: CE
authors: Aubin
authors: Sainte-Justine University Hospital Centre, 3175 Cote-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
authors: Hubert
authors: H
authors: Labelle
authors: Polytechnique Montréal, P.O. Box 6079, Succursale Centre-ville, Montreal, QC, H3C 3A7, Canada. samuel.kadoury@polymtl.ca.|Sainte-Justine University Hospital Centre, 3175 Cote-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada. samuel.kadoury@polymtl.ca.
authors: Samuel
authors: S
authors: Kadoury
mesh_terms: D000293:Adolescent; D000465:Algorithms; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D015994:Incidence; D007738:Kyphosis / Q000000981:diagnostic imaging; D008141:Lordosis / Q000000981:diagnostic imaging; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008297:Male; D012189:Retrospective Studies; D012600:Scoliosis / Q000145:classification* / Q000000981:diagnostic imaging; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging*
keywords: Adolescent idiopathic scoliosis; Cluster analysis; Machine learning; Morphology; Spine