title: [Effects of thyroid autoimmunity on pregnancy outcomes in euthyroid women receiving in vitro fertilization: a meta-analysis].
abstract: OBJECTIVE
  To investigate the association of thyroid autoimmunity (TAI) with pregnancy outcomes in euthyroid women undergoing in vitro fertilization (IVF).
  
  
  METHODS
  The meta-analysis was a systematic review of cohort studies published before May 10th, 2014. Data were retrieved from Medline, Embase and Cochrane library, and the keywords were "thyroid autoimmunity" and "pregnancy outcome", with restriction to artificial reproductive technique. RevMan 5.2 software was used for data analysis.
  
  
  RESULTS
  In all, 11 cohort studies met the inclusion criteria and were included in the meta-analysis. The results showed that TAI was not associated with clinical pregnancy rate (RR=0.99, 95%CI: 0.89-1.11, P=0.92), but significantly associated with miscarriage risk (RR=1.54, 95%CI: 1.24-1.92, P<0.001). Live birth/ongoing pregnancy rate decreased in the TAI group compared with the control group, but there was no statistically significant difference (RR=0.89, 95%CI: 0.79-1.00, P=0.06).
  
  
  CONCLUSIONS
  As for euthyroid women who are receiving IVF, TAI contributes to increased risk of miscarriage. Therefore, we recommend universal screening for thyroid disease among women undergoing IVF.
authors: Department of Endocrinology, Peking University Third Hospital, Beijing 100191, China.
authors: Huinan
authors: H
authors: Wu
authors: Department of Endocrinology, Peking University Third Hospital, Beijing 100191, China.
authors: Tianpei
authors: T
authors: Hong
authors: Department of Endocrinology, Peking University Third Hospital, Beijing 100191, China.
authors: Hongwei
authors: H
authors: Gao
authors: Department of Endocrinology, Peking University Third Hospital, Beijing 100191, China; Email: hainingmail@bjmu.edu.cn.
authors: Haining
authors: H
authors: Wang
mesh_terms: D000022:Abortion, Spontaneous; D015551:Autoimmunity; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D013961:Thyroid Gland