title: Cardiovascular biomarkers in paired maternal and umbilical cord blood samples at term and near term delivery.
abstract: BACKGROUND
  Cardiovascular biomarkers might help to identify fetuses or pregnancies at risk.
  
  
  OBJECTIVE
  To examine the umbilical cord neonatal and maternal levels of cardiovascular biomarkers at the time of delivery, and to correlate maternal and fetal biomarker levels to each other, to gestational age and to delivery mode.
  
  
  METHODS
  In a prospective, observational, cross-sectional, single-center study biomarkers were measured in paired maternal and umbilical venous cord blood samples.
  
  
  METHODS
  The sample cohort included 66 sets of fetal and maternal blood samples (11 after multiple gestation, 53 after cesarean section, 17 after exposure to labor).
  
  
  METHODS
  Midregional pro-adrenomedullin (MRproADM), midregional-pro atrial natriuretic peptide (MRproANP), brain natriuretic peptide (BNP), n-terminal-pro brain natriuretic peptide (NTproBNP), copeptin, and high sensitive troponin I (hsTnI) levels were measured.
  
  
  RESULTS
  Mean ± SEM for biomarker levels in umbilical venous/maternal blood were: MRproADM [nmol/L] 1.02 ± 0.04/1.24 ± 0.08, MRproANP [pmol/L] 215.53 ± 12.96/54.65 ± 3.41, BNP [pg/mL] 32.02 ± 3.37/19.76 ± 3.29, NTproBNP [pg/mL] 1228.94 ± 91.73/71.48 ± 8.65, copeptin [pmol/L] 103.42 ± 22.89/10.41 ± 1.71, and hsTnI [pg/mL] 13.54 ± 5.17/4.91 ± 2.37. Fetal MRproANP, NTproBNP, and BNP were inversely correlated with gestational age. Maternal and fetal MRproANP (r=0.472, p=0.002) and copeptin (r=0.572, p<0.001) levels were correlated, whereas there was no feto-maternal correlation for the other biomarkers. Fetal copeptin was elevated after exposure to labor.
  
  
  CONCLUSIONS
  Biomarker levels appear to be regulated independently in mother and fetus. Fetal biomarkers are influenced by gestational age and delivery mode. In this study on term and near term pregnancies without specific fetal pathology, correlation between paired maternal and fetal biomarker levels was weak or not demonstrable.
authors: University Children's Hospital, Department of Pediatrics, Division of Neonatology and Pediatric Intensive Care, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany. Electronic address: m.blohm@uke.de.
authors: Martin E
authors: ME
authors: Blohm
authors: University Heart Center, Clinic for Pediatric Cardiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Florian
authors: F
authors: Arndt
authors: University Children's Hospital, Department of Pediatrics, Division of Neonatology and Pediatric Intensive Care, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors: Jan
authors: J
authors: Sandig
authors: Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Werner
authors: W
authors: Diehl
authors: University Heart Center, Clinic for General and Interventional Cardiology, German Center for Cardiovascular Research (DZHK), Partner Sites Hamburg, Lübeck, Kiel, Hamburg, Germany.
authors: Tanja
authors: T
authors: Zeller
authors: University Heart Center, Clinic for Pediatric Cardiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Goetz C
authors: GC
authors: Mueller
authors: University Heart Center, Clinic for Pediatric Cardiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Claudia
authors: C
authors: Schlesner
authors: University Heart Center, Clinic for Pediatric Cardiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Thomas S
authors: TS
authors: Mir
authors: University Heart Center, Clinic for General and Interventional Cardiology, German Center for Cardiovascular Research (DZHK), Partner Sites Hamburg, Lübeck, Kiel, Hamburg, Germany.
authors: Stefan
authors: S
authors: Blankenberg
authors: Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Kurt
authors: K
authors: Hecher
authors: University Children's Hospital, Department of Pediatrics, Division of Neonatology and Pediatric Intensive Care, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors: Dominique
authors: D
authors: Singer
authors: University Heart Center, Clinic for Pediatric Cardiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Jochen
authors: J
authors: Weil
mesh_terms: D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008297:Male; D011498:Protein Precursors / Q000097:blood*; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; D011498:Protein Precursors; D019210:Troponin I; C048197:copeptins; C088633:proadrenomedullin; D053607:Adrenomedullin; D009320:Atrial Natriuretic Factor
keywords: Atrial natriuretic factor; Beta-atrial natriuretic peptide; Copeptin; Human; Neonate; Proadrenomedullin; Troponin-I