title: [Monomorphic post-transplant T-lymphoproliferative disorder after autologous stem cell transplantation for multiple myeloma].
abstract: We report a rare case of T cell type monomorphic post-transplant lymphoproliferative disorders (PTLD) after autologous stem cell transplantation. A 53-year-old man with multiple myeloma received autologous stem cell transplantation and achieved a very good partial response. Nine months later, he developed a high fever and consciousness disturbance, and had multiple swollen lymph nodes and a high titer of Epstein-Barr (EB) virus DNA in his peripheral blood. Neither CT nor MRI of the brain revealed any abnormalities. Cerebrospinal fluid contained no malignant cells, but the EB virus DNA titer was high. Lymph node biopsy revealed T cell type monomorphic PTLD. Soon after high-dose treatment with methotrexate and cytosine arabinoside, the high fever and consciousness disturbance subsided, and the lymph node swelling and EB virus DNA disappeared. Given the efficacy of chemotherapy in this case, we concluded that the consciousness disturbance had been induced by central nervous system involvement of monomorphic PTLD.
authors: Department of Medicine and Clinical Science, Gunma University.
authors: Tetsuya
authors: T
authors: Ishikawa
authors: Hiroaki
authors: H
authors: Shimizu
authors: Toshifumi
authors: T
authors: Takei
authors: Hiroko
authors: H
authors: Koya
authors: Hirono
authors: H
authors: Iriuchishima
authors: Takumi
authors: T
authors: Hosiho
authors: Junko
authors: J
authors: Hirato
authors: Masaru
authors: M
authors: Kojima
authors: Hiroshi
authors: H
authors: Handa
authors: Yoshihisa
authors: Y
authors: Nojima
authors: Hirokazu
authors: H
authors: Murakami
mesh_terms: D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009101:Multiple Myeloma / Q000628:therapy*; D049268:Positron-Emission Tomography; D013601:T-Lymphocytes / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous