title: Hyperpolarization MRI: Preclinical Models and Potential Applications in Neuroradiology.
abstract: Hyperpolarization is a novel technology that can dramatically increase signal to noise in magnetic resonance. The method is being applied to small injectable endogenous molecules, which can be used to monitor transient in vivo metabolic events, in real time. The emergence of hyperpolarized C-labeled probes, specifically C pyruvate, has enabled monitoring of core cellular metabolic events. Neuro-oncological applications have been demonstrated in preclinical models. Many more applications of this technology are envisioned, with transformative potential in magnetic resonance imaging.
authors: Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Vesselin Z
authors: VZ
authors: Miloushev
authors: Kayvan R
authors: KR
authors: Keshari
authors: Andrei I
authors: AI
authors: Holodny
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism*; D003198:Computer Simulation; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D057054:Molecular Imaging / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals