title: Expression of Matrix Metalloproteinases-2/-9 is Associated With Microvessel Density in Pancreatic Cancer.
abstract: This study aimed to investigate the association of matrix-metalloproteinase (MMP)-2 and MMP-9 with microvessel density (MVD) in pancreatic cancer. The tumor tissues and para-tumor tissues of 30 patients with pancreatic cancer were pathologically examined. The normal pancreatic tissues of another 17 patients served as controls. The expression of MMP-2 and MMP-9 was examined using immunohistochemistry and scored. The association of MMP-2 and MMP-9 with the MVD values and pathological features were analyzed. The positive expression rates of MMP-2 and MMP-9 in the tumor tissues were significantly higher than those in the para-tumor tissues (P < 0.01). In normal pancreatic tissues, both MMP-2 and MMP-9 expressions were negative. The MVD values increased significantly along with higher tumor node metastasis stages (P = 0.04). The MVD values were positively correlated with MMP-2 scores (r = 0.563, P < 0.05) and MMP-9 scores (r = 0.451, P < 0.05). The expression of MMP-2 and MMP-9 is associated with angiogenesis in pancreatic cancer. MMPs might be used as prognostic factors and therapy targets for patients with pancreatic cancer.
authors: 1Department of Hepatobiliary Surgery, Binzhou People's Hospital, Binzhou, Shandong, China; and 2Section II, Department of Neurology, Binzhou People's Hospital, Binzhou, Shandong, China.
authors: Tinghai
authors: T
authors: Xiang
authors: Xiuliang
authors: X
authors: Xia
authors: Wenyan
authors: W
authors: Yan
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000032:analysis*; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000473:pathology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9