title: Transanal Local Excision for Patients With Rectal Cancer: Can Radiation Compensate for What Is Perceived as a Nondefinitive Surgical Approach?
abstract: BACKGROUND
  Total mesorectal excision has long been the standard of care for patients with rectal cancer. However, in select patients, local excision is an appropriate alternative option. The role of adjuvant radiation therapy in patients treated with local excision is controversial and evidence is lacking.
  
  
  OBJECTIVE
  The purpose of this study was to report oncological outcomes of patients with rectal cancer treated with local excision and adjuvant radiation.
  
  
  METHODS
  This study was a retrospective chart review.
  
  
  METHODS
  The study was conducted at the BC Cancer Agency, a tertiary referral hospital.
  
  
  METHODS
  A total of 93 patients with node-negative rectal cancer treated with local excision and adjuvant radiotherapy between 2001 and 2010 were included in the study.
  
  
  METHODS
  Patient and tumor characteristics are reported. Five-year local control, progression-free survival, and overall survival were analyzed using Kaplan-Meier methods.
  
  
  RESULTS
  Five-year overall survival, local control, and progression-free survival for patients treated with local excision and adjuvant radiotherapy were 78.5%, 86.1%, and 83.8%. In T1 disease, local control was 92.5%.
  
  
  CONCLUSIONS
  Referral bias, selection bias, lack of uniform surveillance, and retrospective analysis are the study limitations.
  
  
  CONCLUSIONS
  Local excision with adjuvant radiotherapy provides a good level of local control in T1 disease and remains a good treatment option for patients who are either medically not suitable for a more radical surgical approach or who refuse this procedure. Local excision and radiotherapy should not be advocated in T2/T3 disease; however, it can provide a good alternative in those patients who are not fit enough for a more radical operation.
authors: 1 BC Cancer Agency, Vancouver, British Columbia, Canada 2 Division of Radiation Oncology, Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada 3 Division of General Surgery, Department of Surgery, St. Paul's Hospital, Vancouver, British Columbia, Canada.
authors: Thomas P
authors: TP
authors: Rackley
authors: Roy M K
authors: RM
authors: Ma
authors: Carl J
authors: CJ
authors: Brown
authors: John H
authors: JH
authors: Hay
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001955:British Columbia / Q000453:epidemiology; D003082:Colectomy / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods*; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends