title: Walking-induced muscle fatigue impairs postural control in adolescents with unilateral spastic cerebral palsy.
abstract: BACKGROUND
  Fatigue is likely to be an important limiting factor in adolescents with spastic cerebral palsy (CP).
  
  
  OBJECTIVE
  To determine the effects of walking-induced fatigue on postural control adjustments in adolescents with unilateral CP and their typically developing (TD) peers.
  
  
  METHODS
  Ten adolescents with CP (14.2 ± 1.7 yr) and 10 age-, weight- and height-matched TD adolescents (14.1 ± 1.9 yr) walked for 15 min on a treadmill at their preferred walking speed. Before and after this task, voluntary strength capacity of knee extensors (MVC) and postural control were evaluated in 3 conditions: eyes open (EO), eyes closed (EC) and with dual cognitive task (EODT).
  
  
  RESULTS
  After walking, MVC decreased significantly in CP (-11%, P<0.05) but not in TD. The CoP area was only significantly increased in CP (90%, 34% and 60% for EO, EC and EODT conditions, respectively). The CoP length was significantly increased in the EO condition in CP and TD (20% and 21%) and was significantly increased in the EODT condition by 18% in CP only.
  
  
  CONCLUSIONS
  Unlike TD adolescents, treadmill walking for 15 min at their preferred speed lead to significant knee extensor strength losses and impairments in postural control in adolescents with unilateral spastic CP.
authors: Laboratory of Fundamental and Applied Bioenergetics, Inserm U1055, University of Grenoble, Grenoble, France; University of Health Sciences, University of Applied Sciences and Arts Western, Lausanne, Switzerland.
authors: Damien
authors: D
authors: Vitiello
authors: Institute of Sport Sciences University of Lausanne (ISSUL), University of Lausanne, Lausanne, Switzerland.
authors: Ludmilla
authors: L
authors: Pochon
authors: Institute of Sport Sciences University of Lausanne (ISSUL), University of Lausanne, Lausanne, Switzerland; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
authors: Davide
authors: D
authors: Malatesta
authors: Institute of Sport Sciences University of Lausanne (ISSUL), University of Lausanne, Lausanne, Switzerland; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
authors: Olivier
authors: O
authors: Girard
authors: Pediatric Neurology and Neurorehabilitation Unit, Lausanne University Hospital, Lausanne, Switzerland.
authors: Christopher J
authors: CJ
authors: Newman
authors: University of Health Sciences, University of Applied Sciences and Arts Western, Lausanne, Switzerland; Institute of Sport Sciences University of Lausanne (ISSUL), University of Lausanne, Lausanne, Switzerland. Electronic address: francis.degache@hesav.ch.
authors: Francis
authors: F
authors: Degache
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000503:physiopathology* / Q000523:psychology; D003071:Cognition; D005260:Female; D006801:Humans; D008297:Male; D018763:Muscle Fatigue / Q000502:physiology*; D018482:Muscle, Skeletal / Q000503:physiopathology; D004856:Postural Balance / Q000502:physiology*; D052097:Quadriceps Muscle / Q000503:physiopathology*; D013647:Task Performance and Analysis; D016138:Walking
keywords: Hemiplegic adolescents; Muscle weakness; Postural control; Standing