title: Mutated tau, amyloid and neuroinflammation in Alzheimer disease-A brief review.
abstract: This review discussed the importance of mutated tau, amyloid and neuroinflammatory factors and microglia in Alzheimer disease. In particular tau, CD4 and TNF alpha were included in the review and the colocalizations of these factors were highlighted. It is important to realize the Alzheimer disease may result from the interactions of these factors. Some of these factors may coexist at the same region and at the same time e.g. mutated tau and amyloid in plaques. A summary scheme of etiology leading to the disease was included.
authors: Schools of Biomedical Sciences and Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. Electronic address: angelahungsm@link.cuhk.edu.hk.
authors: A S M
authors: AS
authors: Hung
authors: School of Medicine, Taizhou University, Taizhou, Zhejiang, China. Electronic address: liangytu@aliyun.com.
authors: Y
authors: Y
authors: Liang
authors: Schools of Biomedical Sciences and Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. Electronic address: tonychowbr@gmail.com.
authors: Tony C H
authors: TC
authors: Chow
authors: Schools of Biomedical Sciences and Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. Electronic address: jonathanhctang@gmail.com.
authors: H C
authors: HC
authors: Tang
authors: Schools of Biomedical Sciences and Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. Electronic address: sharonlywu@gmail.com.
authors: Sharon L Y
authors: SL
authors: Wu
authors: Schools of Biomedical Sciences and Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. Electronic address: mariasmwai@cuhk.edu.hk.
authors: M S M
authors: MS
authors: Wai
authors: Schools of Biomedical Sciences and Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. Electronic address: david-yew@cuhk.edu.hk.
authors: D T
authors: DT
authors: Yew
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D058227:Amyloidogenic Proteins / Q000235:genetics* / Q000276:immunology; D000818:Animals; D001921:Brain / Q000276:immunology / Q000473:pathology; D015704:CD4 Antigens / Q000235:genetics / Q000276:immunology; D016923:Cell Death; D015870:Gene Expression; D006801:Humans; D007249:Inflammation; D017628:Microglia / Q000276:immunology / Q000473:pathology; D009154:Mutation; D058225:Plaque, Amyloid / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology; D016875:tau Proteins / Q000235:genetics* / Q000276:immunology
chemical_list: D058227:Amyloidogenic Proteins; D015704:CD4 Antigens; D014409:Tumor Necrosis Factor-alpha; D016875:tau Proteins
keywords: Amyloid; CD4; Microglia; Mutated tau; TNF alpha