title: Positive Association Between Betatrophin and Diabetic Retinopathy Risk in Type 2 Diabetes Patients.
abstract: Betatrophin is a recently identified protein that has been shown to be associated with lipid metabolism and insulin resistance. This study aimed to measure serum betatrophin concentrations in patients with type 2 diabetes (T2DM) and evaluate the association of betatrophin with diabetic retinopthy (DR). Serum betatrophin concentrations were compared between (1) gender-, age- and body mass index-matched T2DM patients with (n=17) or without (n=33) DR; (2) gender-, age-, and body mass index-matched healthy subjects (n=31), newly-diagnosed T2DM patients before treatment (n=24), and T2DM patients under antidiabetic treatment (n=35). Serum betatrophin concentrations were determined by the enzyme-linked immunosorbent assay. Multivariate logistic regression was performed to assess the association between betatrophin concentration and DR. Serum betatrophin concentration was significantly associated with DR in T2DM patients under treatment (Odds Ratio 2.01; 95% Confidence Interval 1.12-3.60; p=0.019). Betatrophin concentrations were significantly increased in treated T2DM patients compared to the healthy subjects (4.17±0.60 vs. 0.54±0.07 ng/ml; p<0.001). Serum betatrophin concentrations are increased in T2DM patients under antidiabetic treatment and positively associated with diabetic retinopathy.
authors: Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Y-Y
authors: YY
authors: Wang
authors: Department of Special Medicine, School of Medicine, Qingdao University, Qingdao, China.
authors: D
authors: D
authors: Zhang
authors: Department of Physiology, School of Medicine, Qingdao University, Qingdao, China.
authors: Z-Y
authors: ZY
authors: Jiang
authors: School of Public Health, Qingdao University, Qingdao, China.
authors: X-Q
authors: XQ
authors: Lu
authors: Clinical Laboratory, Qingdao Municipal Hospital, Qingdao, China.
authors: X
authors: X
authors: Zheng
authors: Department of Special Medicine, School of Medicine, Qingdao University, Qingdao, China.
authors: Y-J
authors: YJ
authors: Yu
authors: Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Y-G
authors: YG
authors: Wang
authors: Department of Special Medicine, School of Medicine, Qingdao University, Qingdao, China.|Department of Physiology, School of Medicine, Qingdao University, Qingdao, China.
authors: J
authors: J
authors: Dong
mesh_terms: D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications* / Q000188:drug therapy; D003930:Diabetic Retinopathy / Q000097:blood* / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood*; D012307:Risk Factors
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D036361:Peptide Hormones