title: Autoantibodies directed to centromere protein F in a patient with BRCA1 gene mutation.
abstract: BACKGROUND
  Autoantibodies directed to centromere protein F were first reported in 1993 and their association with malignancy has been well documented.
  
  
  METHODS
  We present the case of a 48-year-old Caucasian female with a BRCA1 gene mutation associated with bilateral breast cancer. Antinuclear autoantibody immunofluorescence performed for workup of possible inflammatory arthropathy showed a high titre cell cycle related nuclear speckled pattern, with subsequent confirmation by addressable laser bead immunoassay of the target antigen as an immunodominant epitope at the C-terminus of centromere protein F.
  
  
  CONCLUSIONS
  Here we review the current literature on centromere protein F, its association with breast cancer and present the first case of this antibody being identified in a person with a BRCA1 gene mutation.
authors: Australian Clinical Laboratories, Melbourne, Australia. moghaddas.f@wehi.edu.au.
authors: Fiona
authors: F
authors: Moghaddas
authors: Department of Rheumatology, Prince of Wales Hospital, Sydney, Australia. fredjoshua@unsw.edu.au.
authors: Fredrick
authors: F
authors: Joshua
authors: Australian Clinical Laboratories, Melbourne, Australia. Roberta.Taylor@clinicallabs.com.au.
authors: Roberta
authors: R
authors: Taylor
authors: Department of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada. fritzler@ucalgary.ca.
authors: Marvin J
authors: MJ
authors: Fritzler
authors: Australian Clinical Laboratories, Melbourne, Australia. ban-hock.toh@monash.edu.|Department of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia. ban-hock.toh@monash.edu.
authors: Ban Hock
authors: BH
authors: Toh
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D002453:Cell Cycle / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone / Q000276:immunology*; D005260:Female; D019398:Genes, BRCA1; D006801:Humans; D008840:Microfilament Proteins / Q000276:immunology*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*
chemical_list: D001323:Autoantibodies; D002868:Chromosomal Proteins, Non-Histone; D008840:Microfilament Proteins; C094772:centromere protein F