title: Different mechanisms of risperidone result in improved interpersonal trust, social engagement and cooperative behavior in patients with schizophrenia compared to trifluoperazine.
abstract: OBJECTIVE
  Atypical antipsychotic treatment (e.g. risperidone) has been found to improve social functioning more than standard antipsychotic treatment. However, it is unclear which specific social behaviors are implicated in this improvement. The current study employed an interactive puzzle game to examine how social behaviors contribute to the improvement of social functioning by comparing patients receiving risperidone with those receiving trifluoperazine.
  
  
  METHODS
  Scores on the Positive and Negative Syndrome Scale, executive functioning, and social functioning were obtained from 24 patients with schizophrenia receiving either risperidone (n = 12) or trifluoperazine (n = 12), before their social behavior was measured in the interactive Tangrams Game. Immediately after the Tangrams Game, participants filled in two questionnaires measuring their interpersonal trust and rejection toward their game partner.
  
  
  RESULTS
  Patients receiving risperidone showed more social engagement, cooperative behavior and interpersonal trust toward their game partners than those receiving trifluoperazine. Additional multivariate analysis of variance revealed that lower affiliative behavior was a function of positive symptoms; interpersonal trust had an impact on social engagement but executive functioning did not explain lower interpersonal trust or social disengagement.
  
  
  CONCLUSIONS
  Improvement of social competence by risperidone might be related to the enhancement of both social behaviors and interpersonal trust as well as better symptom resolution.
authors: Department of Educational Psychology, Chinese University of Hong Kong, Hong Kong, China.
authors: Wai Shing
authors: WS
authors: Tse
authors: Department of Applied Social Studies, City University of Hong Kong, Hong Kong, China.
authors: Ann Siu Wah
authors: AS
authors: Wong
authors: Department of Psychiatry, North District Hospital, Hong Kong, China.
authors: Fu
authors: F
authors: Chan
authors: Department of Psychiatry, North District Hospital, Hong Kong, China.
authors: Alfred Hin Tat
authors: AH
authors: Pang
authors: Department of Addiction, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
authors: Alyson Jane
authors: AJ
authors: Bond
authors: Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors: Chau Kiu Raymond
authors: CK
authors: Chan
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007398:Interpersonal Relations; D018967:Risperidone / Q000008:administration & dosage / Q000494:pharmacology*; D012559:Schizophrenia / Q000188:drug therapy*; D066107:Social Skills; D016896:Treatment Outcome; D014268:Trifluoperazine / Q000008:administration & dosage / Q000494:pharmacology*; D035502:Trust
chemical_list: D014150:Antipsychotic Agents; D014268:Trifluoperazine; D018967:Risperidone
keywords: atypical antipsychotics; psychopharmacology; schizophrenia; social behavior; trust