title: Novel Silicone-Coated 125I Seeds for the Treatment of Extrahepatic Cholangiocarcinoma.
abstract: 125I seeds coated with titanium are considered a safe and effective interstitial brachytherapy for tumors, while the cost of 125I seeds is a major problem for the patients implanting lots of seeds. The aim of this paper was to develop a novel silicone coating for 125I seeds with a lower cost. In order to show the radionuclide utilization ratio, the silicone was coated onto the seeds using the electro-spinning method and the radioactivity was evaluated, then the anti-tumor efficacy of silicone 125I seeds was compared with titanium 125I seeds. The seeds were divided into four groups: A (control), B (pure silicone), C (silicone 125I), D (titanium 125I) at 2 Gy or 4 Gy. Their anti-tumour activity and mechanism were assessed in vitro and in vivo using a human extrahepatic cholangiocarcinoma cell line FRH-0201 and tumor-bearing BALB/c nude mice. The silicone 125I seeds showed higher radioactivity; the rate of cell apoptosis in vitro and the histopathology in vivo demonstrated that the silicone 125I seeds shared similar anti-tumor efficacy with the titanium 125I seeds for the treatment of extrahepatic cholangiocarcinoma, while they have a much lower cost.
authors: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, People's Republic of China.
authors: Lizhou
authors: L
authors: Lin
authors: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, People's Republic of China.
authors: Lili
authors: L
authors: Guo
authors: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, People's Republic of China.
authors: Weixing
authors: W
authors: Zhang
authors: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, People's Republic of China.
authors: Xiaobo
authors: X
authors: Cai
authors: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, People's Republic of China.
authors: Dafan
authors: D
authors: Chen
authors: Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, People's Republic of China.
authors: Xinjian
authors: X
authors: Wan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D001650:Bile Duct Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D001918:Brachytherapy / Q000379:methods*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000528:radiation effects; D018281:Cholangiocarcinoma / Q000473:pathology* / Q000532:radiotherapy*; D004195:Disease Models, Animal; D006801:Humans; D007457:Iodine Radioisotopes; D051379:Mice; D012828:Silicones; D023041:Xenograft Model Antitumor Assays
chemical_list: D007457:Iodine Radioisotopes; D012828:Silicones