title: [Developmental and environnemental origin of male infertility: role of endocrine disruptors].
abstract: Human and wildlife exposure to chemicals is thought to be extensive and particularly to endocrine-disrupting chemicals (EDCs) suspected to alter male reproductive tract. When the exposure occurs during perinatal period (fetal, neonatal periods or puberty) the reproductive health alterations are irreversible suggesting a developmental origin to male infertility. This concept is supported by numerous epidemiologic and experimental studies. This review summarizes the data concerning the epigenetic mechanisms (DNA methylation, chromatin remodelling, small-non coding RNAs) involved in developmentally-induced male infertility. These data open potentially to new diagnosis tools and new trails to assessment of EDCs risks.
authors: Inserm, U1065, centre méditerranéen de médecine moléculaire (C3M), équipe 5, Centre hospitalier l'Archet 2, 151, route St Antoine Ginestière, Nice, F-06204, France - Université de Nice-Sophia, UFR médecine, Nice, F-06000, France - Université Lyon 1, UFR médecine Lyon sud, Lyon, F-69921, France - Hospices civils de Lyon, hôpital Lyon sud, laboratoire d'anatomie et de cytologie pathologiques, Pierre-Bénite, F-69495, France.
authors: Claire
authors: C
authors: Mauduit
authors: Inserm, U1065, centre méditerranéen de médecine moléculaire (C3M), équipe 5, Centre hospitalier l'Archet 2, 151, route St Antoine Ginestière, Nice, F-06204, France - Université de Nice-Sophia, UFR médecine, Nice, F-06000, France.
authors: Bénazir
authors: B
authors: Siddeek
authors: Inserm, U1065, centre méditerranéen de médecine moléculaire (C3M), équipe 5, Centre hospitalier l'Archet 2, 151, route St Antoine Ginestière, Nice, F-06204, France - Université de Nice-Sophia, UFR médecine, Nice, F-06000, France - Centre hospitalier universitaire de Nice, pôle digestif reproduction, CECOS, Nice, F-06202, France.
authors: Mohamed
authors: M
authors: Benahmed
mesh_terms: D000328:Adult; D000818:Animals; D000835:Animals, Wild; D052244:Endocrine Disruptors / Q000494:pharmacology / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007248:Infertility, Male / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants