title: Multiple Imputation for General Missing Data Patterns in the Presence of High-dimensional Data.
abstract: Multiple imputation (MI) has been widely used for handling missing data in biomedical research. In the presence of high-dimensional data, regularized regression has been used as a natural strategy for building imputation models, but limited research has been conducted for handling general missing data patterns where multiple variables have missing values. Using the idea of multiple imputation by chained equations (MICE), we investigate two approaches of using regularized regression to impute missing values of high-dimensional data that can handle general missing data patterns. We compare our MICE methods with several existing imputation methods in simulation studies. Our simulation results demonstrate the superiority of the proposed MICE approach based on an indirect use of regularized regression in terms of bias. We further illustrate the proposed methods using two data examples.
authors: Department of Biostatistics and Bioinformatics, Emory University, Atlanta, 30322, USA.
authors: Yi
authors: Y
authors: Deng
authors: Department of Biostatistics and Bioinformatics, Emory University, Atlanta, 30322, USA.
authors: Changgee
authors: C
authors: Chang
authors: Georgia Department of Public Health, 30303, USA.
authors: Moges Seyoum
authors: MS
authors: Ido
authors: Department of Biostatistics and Bioinformatics, Emory University, Atlanta, 30322, USA.
authors: Qi
authors: Q
authors: Long
mesh_terms: D019295:Computational Biology / Q000379:methods*; D066264:Datasets as Topic; D001330:Electronic Data Processing / Q000379:methods*; D008962:Models, Theoretical