title: Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice.
abstract: Hearing loss has been associated with cognitive decline in the elderly and is considered to be an independent risk factor for dementia. One of the most common causes for acquired sensorineural hearing loss is exposure to excessive noise, which has been found to impair learning ability and cognitive performance in human subjects and animal models. Noise exposure has also been found to depress neurogenesis in the hippocampus. However, the effect is mainly attributed to the oxidant stress of noise on the cognitive brain. In the present study, young adult CBA/CAJ mice (between 1.5 and 2 months of age) were briefly exposed a high sound level to produce moderate-to-severe hearing loss. In both the blood and hippocampus, only transient oxidative stress was observed after noise exposure. However, a deficit in spatial learning/memory was revealed 3 months after noise exposure. Moreover, the deficit was correlated with the degree of hearing loss and was associated with a decrease in neurogenesis in the hippocampus. We believe that the observed effects were likely due to hearing loss rather than the initial oxidant stress, which only lasted for a short period of time.
authors: Department of Physiology, Medical College of Southeast University, Nanjing China.
authors: Lijie
authors: L
authors: Liu
authors: Department of Physiology, Medical College of Southeast University, Nanjing China.
authors: Pei
authors: P
authors: Shen
authors: Department of Physiology, Medical College of Southeast University, Nanjing China.
authors: Tingting
authors: T
authors: He
authors: Department of Physiology, Medical College of Southeast University, Nanjing China.
authors: Ying
authors: Y
authors: Chang
authors: Department of Physiology, Medical College of Southeast University, Nanjing China.
authors: Lijuan
authors: L
authors: Shi
authors: Department of Physiology, Medical College of Southeast University, Nanjing China.
authors: Shan
authors: S
authors: Tao
authors: Department of Physiology, Medical College of Southeast University, Nanjing China.
authors: Xiaowei
authors: X
authors: Li
authors: Department of Physiology, Medical College of Southeast University, Nanjing China.
authors: Qingying
authors: Q
authors: Xun
authors: Department of Physiology, Medical College of Southeast University, Nanjing China.|Children's medical center, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: Xiaojing
authors: X
authors: Guo
authors: School of Human Communication Disorders, Dalhousie University, Halifax, Canada.
authors: Zhiping
authors: Z
authors: Yu
authors: Department of Physiology, Medical College of Southeast University, Nanjing China.|School of Human Communication Disorders, Dalhousie University, Halifax, Canada.
authors: Jian
authors: J
authors: Wang
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D006317:Hearing Loss, Noise-Induced / Q000378:metabolism / Q000473:pathology*; D006624:Hippocampus / Q000378:metabolism*; D051379:Mice; D008808:Mice, Inbred CBA; D055495:Neurogenesis; D018384:Oxidative Stress; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D065853:Spatial Learning / Q000502:physiology*; D065852:Spatial Memory / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D003345:Corticosterone