title: Effect of parsley (Petroselinum crispum, Apiaceae) juice against cadmium neurotoxicity in albino mice (Mus musculus).
abstract: BACKGROUND
  Parsley was employed as an experimental probe to prevent the behavioral, biochemical and morphological changes in the brain tissue of the albino mice following chronic cadmium (Cd) administration.
  
  
  METHODS
  Non-anesthetized adult male mice were given parsley juice (Petroselinum crispum, Apiaceae) daily by gastric intubation at doses of 10 and 20 g/kg/day. The animals were divided into six groups: Group A, mice were exposed to saline; Groups B and C, were given low and high doses of parsley juice, respectively; Group D, mice were exposed to Cd; Groups E and F, were exposed to Cd and concomitantly given low and high doses of parsley, respectively.
  
  
  RESULTS
  Cd intoxication can cause behavioral abnormalities, biochemical and histopathological disturbances in treated mice. Parsley juice has significantly improved the Cd-associated behavioral changes, reduced the elevation of lipid peroxidation and normalized the Cd effect on reduced glutathione and peroxidase activities in the brain of treated mice. Histological data have supported these foundations whereas Cd treatment has induced neuronal degeneration, chromatolysis and pyknosis in the cerebrum, cerebellum and medulla oblongata.
  
  
  CONCLUSIONS
  The low dose (5 g/kg/day) of parsley exhibited beneficial effects in reducing the deleterious changes associated with Cd treatment on the behavior, neurotransmitters level, oxidative stress and brain neurons of the Cd-treated mice.
authors: Department of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. maodaa_28@yahoo.com.
authors: Saleh N
authors: SN
authors: Maodaa
authors: Department of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. aallam@ksu.edu.sa.|Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt. aallam@ksu.edu.sa.
authors: Ahmed A
authors: AA
authors: Allam
authors: Department of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. jajarem@ksu.edu.sa.
authors: Jamaan
authors: J
authors: Ajarem
authors: Department of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. harrany@gmail.com.
authors: Mostafa A
authors: MA
authors: Abdel-Maksoud
authors: Department of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. galbeshr@gmail.com.
authors: Gadah I
authors: GI
authors: Al-Basher
authors: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing, 210023, Jiangsu, People's Republic of China. wangzun315cn@163.com.
authors: Zun Yao
authors: ZY
authors: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002104:Cadmium / Q000633:toxicity; D002105:Cadmium Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000067030:Fruit and Vegetable Juices; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D020258:Neurotoxicity Syndromes / Q000188:drug therapy* / Q000209:etiology; D018384:Oxidative Stress / Q000187:drug effects; D028528:Petroselinum / Q000737:chemistry*; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D002104:Cadmium