title: Functions of Rab Proteins at Presynaptic Sites.
abstract: Presynaptic neurotransmitter release is dominated by the synaptic vesicle (SV) cycle and entails the biogenesis, fusion, recycling, reformation or turnover of synaptic vesicles-a process involving bulk movement of membrane and proteins. As key mediators of membrane trafficking, small GTPases from the Rab family of proteins play critical roles in this process by acting as molecular switches that dynamically interact with and regulate the functions of different sets of macromolecular complexes involved in each stage of the cycle. Importantly, mutations affecting Rabs, and their regulators or effectors have now been identified that are implicated in severe neurological and neurodevelopmental disorders. Here, we summarize the roles and functions of presynaptic Rabs and discuss their involvement in the regulation of presynaptic function.
authors: Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen 37077, Germany.
authors: Beyenech
authors: B
authors: Binotti
authors: Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen 37077, Germany.
authors: Reinhard
authors: R
authors: Jahn
authors: Interactomics and Intracellular Trafficking laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore. phsjcje@nus.edu.sg.|Neurobiology/Ageing Programme, National University of Singapore, Singapore 117456, Singapore. phsjcje@nus.edu.sg.|Research Group Protein trafficking in synaptic development and function, Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen 37077, Germany. phsjcje@nus.edu.sg.
authors: John Jia En
authors: JJ
authors: Chua
keywords: Presynapse; Rabs; autophagy; intracellular membrane trafficking; small GTPases; synaptic transmission; synaptic vesicle cycle