title: Stereotactic body radiation therapy for non-spine bone metastases--a review of the literature.
abstract: BACKGROUND
  Stereotactic body radiation therapy (SBRT) has the ability to deliver significantly higher biologically equivalent doses (BED) compared to conventional radiation treatment. The main goal of SBRT is to improve local tumor control while reducing pain. The side effects however may be greater than those of conventional treatment.
  
  
  METHODS
  A review of the literature was conducted and articles pertaining to studies of SBRT in non-spine bone metastases were included. Data on outcomes and toxicities were collected in addition to inclusion and exclusion criteria for each study.
  
  
  RESULTS
  A total of 14 studies were included in this review. Very rarely were grade 3 and 4 toxicities reported. Endpoints for the studies varied significantly, which made conclusions of overall local control and progression free survival near impossible. In studies that reported local control rates, these rates were all greater than 85%. Progression free survival varied significantly between studies.
  
  
  CONCLUSIONS
  Due to the lack of consistency in endpoint definitions, it is difficult to compare outcomes across trials. There is a need for consensus in endpoint definitions.
authors: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Gillian
authors: G
authors: Bedard
authors: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Rachel
authors: R
authors: McDonald
authors: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Ian
authors: I
authors: Poon
authors: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Darby
authors: D
authors: Erler
authors: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Hany
authors: H
authors: Soliman
authors: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Patrick
authors: P
authors: Cheung
authors: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Hans
authors: H
authors: Chung
authors: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: William
authors: W
authors: Chu
authors: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Andrew
authors: A
authors: Loblaw
authors: Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada. Edward.Chow@sunnybrook.ca.
authors: Edward
authors: E
authors: Chow
authors: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Arjun
authors: A
authors: Sahgal
mesh_terms: D001859:Bone Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D002986:Clinical Trials as Topic; D018572:Disease-Free Survival; D006801:Humans; D059352:Musculoskeletal Pain / Q000517:prevention & control; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome
keywords: Stereotactic radiation therapy; bone metastases; oligometastases; review