title: The Past, Present, and (Possible) Future of Serologic Testing for Lyme Disease.
abstract: Lyme disease prevails as the most commonly transmitted tick-borne infection in the United States, and serologic evaluation for antibodies to Borrelia burgdorferi remains the recommended modality for diagnosis. This review presents a brief historical perspective on the evolution of serologic assays for Lyme disease and provides a summary of the performance characteristics for the currently recommended two-tiered testing algorithm (TTTA). Additionally, a recently proposed alternative to the traditional TTTA is discussed, and novel methodologies, including immuno-PCR and metabolic profiling for Lyme disease, are outlined.
authors: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA theel.elitza@mayo.edu.
authors: Elitza S
authors: ES
authors: Theel
mesh_terms: D000465:Algorithms; D000907:Antibodies, Bacterial / Q000097:blood*; D025065:Borrelia burgdorferi / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis*; D055432:Metabolomics / Q000379:methods; D016133:Polymerase Chain Reaction / Q000379:methods; D012698:Serologic Tests / Q000266:history* / Q000639:trends*; D014481:United States
chemical_list: D000907:Antibodies, Bacterial