title: Translation regulation via nascent polypeptide-mediated ribosome stalling.
abstract: As the nascent polypeptide chain is being synthesized, it passes through a tunnel within the large ribosomal subunit. Interaction between the nascent polypeptide chain and the ribosomal tunnel can modulate the translation rate and induce translational stalling to regulate gene expression. In this article, we highlight recent structural insights into how the nascent polypeptide chain, either alone or in cooperation with co-factors, can interact with components of the ribosomal tunnel to regulate translation via inactivating the peptidyltransferase center of the ribosome and inducing ribosome stalling.
authors: Gene Center and Department of Biochemistry, Feodor-Lynenstr. 25, 81377 Munich, Germany; Center for Integrated Protein Science, Munich (CiPSM), Feodor-Lynenstr. 25, 81377 Munich, Germany. Electronic address: Wilson@lmb.uni-muenchen.de.
authors: Daniel N
authors: DN
authors: Wilson
authors: Gene Center and Department of Biochemistry, Feodor-Lynenstr. 25, 81377 Munich, Germany.
authors: Stefan
authors: S
authors: Arenz
authors: Gene Center and Department of Biochemistry, Feodor-Lynenstr. 25, 81377 Munich, Germany; Center for Integrated Protein Science, Munich (CiPSM), Feodor-Lynenstr. 25, 81377 Munich, Germany. Electronic address: Beckmann@lmb.uni-muenchen.de.
authors: Roland
authors: R
authors: Beckmann
mesh_terms: D016366:Open Reading Frames; D010455:Peptides / Q000737:chemistry*; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000737:chemistry*; D014759:Viral Envelope Proteins / Q000737:chemistry
chemical_list: D010455:Peptides; C082590:UL4 protein, Human cytomegalovirus; D014759:Viral Envelope Proteins