title: Imaging and Data Acquisition in Clinical Trials for Radiation Therapy.
abstract: Cancer treatment evolves through oncology clinical trials. Cancer trials are multimodal and complex. Assuring high-quality data are available to answer not only study objectives but also questions not anticipated at study initiation is the role of quality assurance. The National Cancer Institute reorganized its cancer clinical trials program in 2014. The National Clinical Trials Network (NCTN) was formed and within it was established a Diagnostic Imaging and Radiation Therapy Quality Assurance Organization. This organization is Imaging and Radiation Oncology Core, the Imaging and Radiation Oncology Core Group, consisting of 6 quality assurance centers that provide imaging and radiation therapy quality assurance for the NCTN. Sophisticated imaging is used for cancer diagnosis, treatment, and management as well as for image-driven technologies to plan and execute radiation treatment. Integration of imaging and radiation oncology data acquisition, review, management, and archive strategies are essential for trial compliance and future research. Lessons learned from previous trials are and provide evidence to support diagnostic imaging and radiation therapy data acquisition in NCTN trials.
authors: Imaging and Radiation Oncology Core Rhode Island, University of Massachusetts Memorial Medical Center, University of Massachusetts Medical School, Worcester, Massachusetts. Electronic address: Thomas.Fitzgerald@umassmed.edu.
authors: Thomas J
authors: TJ
authors: FitzGerald
authors: Imaging and Radiation Oncology Core Rhode Island, University of Massachusetts Medical School, Worcester, Massachusetts.
authors: Maryann
authors: M
authors: Bishop-Jodoin
authors: Imaging and Radiation Oncology Core Houston, University of Texas MD Anderson Cancer Center, Houston, Texas.
authors: David S
authors: DS
authors: Followill
authors: Imaging and Radiation Oncology Core Philadelphia, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors: James
authors: J
authors: Galvin
authors: Imaging and Radiation Oncology Core Ohio, Wexner Medical Center, Ohio State University, Columbus, Ohio.
authors: Michael V
authors: MV
authors: Knopp
authors: Imaging and Radiation Oncology Core St. Louis, Washington University School of Medicine, St. Louis, Missouri.
authors: Jeff M
authors: JM
authors: Michalski
authors: Imaging and Radiation Oncology Core Philadelphia, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors: Mark A
authors: MA
authors: Rosen
authors: Washington University School of Medicine-Radiation Oncology, St. Louis, Missouri.
authors: Jeffrey D
authors: JD
authors: Bradley
authors: National Cancer Institute, Clinical Radiation Oncology Branch, Rockville, Maryland.
authors: Lalitha K
authors: LK
authors: Shankar
authors: Imaging and Radiation Oncology Core Rhode Island, University of Massachusetts Medical School, Worcester, Massachusetts.
authors: Fran
authors: F
authors: Laurie
authors: Imaging and Radiation Oncology Core Rhode Island, University of Massachusetts Memorial Medical Center, University of Massachusetts Medical School, Worcester, Massachusetts.
authors: M Giulia
authors: MG
authors: Cicchetti
authors: Imaging and Radiation Oncology Core Rhode Island, University of Massachusetts Memorial Medical Center, University of Massachusetts Medical School, Worcester, Massachusetts.
authors: Janaki
authors: J
authors: Moni
authors: National Cancer Institute, Clinical Radiation Oncology Branch, Rockville, Maryland.
authors: C Norman
authors: CN
authors: Coleman
authors: National Cancer Institute, Clinical Radiation Oncology Branch, Rockville, Maryland.
authors: James A
authors: JA
authors: Deye
authors: National Cancer Institute, Clinical Radiation Oncology Branch, Rockville, Maryland.
authors: Jacek
authors: J
authors: Capala
authors: National Cancer Institute, Clinical Radiation Oncology Branch, Rockville, Maryland.
authors: Bhadrasain
authors: B
authors: Vikram
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy; D002648:Child; D002986:Clinical Trials as Topic / Q000592:standards*; D003625:Data Collection / Q000592:standards; D003952:Diagnostic Imaging / Q000379:methods / Q000592:standards*; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis / Q000532:radiotherapy; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D054547:National Cancer Institute (U.S.) / Q000458:organization & administration*; D009369:Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D057285:Precision Medicine; D011785:Quality Assurance, Health Care; D014481:United States