title: Targeting Dysbiosis for the Treatment of Liver Disease.
abstract: The gut microbiome is composed of a vast number of microbes in the gastrointestinal tract, which benefit host metabolism, aid in digestion, and contribute to normal immune function. Alterations in microbial composition can result in intestinal dysbiosis, which has been implicated in several diseases including obesity, inflammatory bowel disease, and liver diseases. Over the past several years, significant interactions between the intestinal microbiota and liver have been discovered, with possible mechanisms for the development as well as progression of liver disease and promising therapeutic targets to either prevent or halt the progression of liver disease. In this review the authors examine mechanisms of dysbiosis-induced liver disease; highlight current knowledge regarding the role of dysbiosis in nonalcoholic liver disease, alcoholic liver disease, and cirrhosis; and discuss potential therapeutic targets.
authors: Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, California.
authors: Gobind
authors: G
authors: Anand
authors: Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, California.
authors: Amir
authors: A
authors: Zarrinpar
authors: Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, California.
authors: Rohit
authors: R
authors: Loomba
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D019587:Dietary Supplements / Q000009:adverse effects; D064806:Dysbiosis; D000069467:Fecal Microbiota Transplantation / Q000009:adverse effects; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008099:Liver / Q000382:microbiology*; D008107:Liver Diseases / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D056692:Prebiotics; D019936:Probiotics / Q000627:therapeutic use; D058616:Synbiotics; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D056692:Prebiotics