title: Squamous Cell Cancer of Unknown Primary and Primary Breast Cancer in an HIV-Infected Woman: The Importance of Cancer Screening for People Living with HIV/AIDS.
abstract: People living with HIV/AIDS (PLWHA) are surviving longer, with an increased risk of cancer. Cancer screening strategies in PLWHA are lacking. We describe the case of a woman with a history of AIDS, who had a nondetectable viral load on treatment. She is an activist, promoting HIV care, but had not undergone routine screening for breast, cervical, or colonic neoplasia. She presented with a left groin mass, which on biopsy proved to be a p16 immuno-histochemical positive squamous cell carcinoma. Anal and cervicovaginal examinations did not show invasive cancer, although high-resolution anoscopy identified high-grade anal dysplasia. A mammogram followed by magnetic resonance imaging showed invasive ductal carcinoma. Her breast cancer was treated with lumpectomy, adjuvant brachytherapy and chemotherapy. The left groin tumor was treated with chemo-radiation. Herein, we also review medical literature concerning anal, cervical, breast, colorectal, and lung cancer screening for PLWHA, which is important for our aging population of PLWHA.
authors: Division of General Internal Medicine, Virginia Mason Medical Center, Seattle, WA, USA.
authors: Joshua
authors: 0000-0002-6752-3530
authors: J
authors: Gulvin
authors: Section of Hematology and Oncology, Virginia Mason Medical Center, Seattle, WA, USA Division of Hematology, University of Washington, Seattle, WA, USA hemdma@virginiamason.org.
authors: David M
authors: DM
authors: Aboulafia
mesh_terms: D001943:Breast Neoplasms / Q000150:complications / Q000000981:diagnostic imaging; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000000981:diagnostic imaging / Q000556:secondary; D055088:Early Detection of Cancer; D005260:Female; D006119:Groin / Q000000981:diagnostic imaging / Q000473:pathology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D030361:Papillomavirus Infections
keywords: HIV/AIDS; HPV; cancer of unknown primary; cancer screening