title: A Complete Optical Sensor System Based on a POF-SPR Platform and a Thermo-Stabilized Flow Cell for Biochemical Applications.
abstract: An optical sensor platform based on surface plasmon resonance (SPR) in a plastic optical fiber (POF) integrated into a thermo-stabilized flow cell for biochemical sensing applications is proposed. This device has been realized and experimentally tested by using a classic receptor-analyte assay. For this purpose, the gold surface of the POF was chemically modified through the formation of a self-assembling monolayer. The surface robustness of the POF-SPR platform has been tested for the first time thanks to the flow cell. The experimental results show that the proposed device can be successfully used for label-free biochemical sensing. The final goal of this work is to achieve a complete, small-size, simple to use and low cost optical sensor system. The whole system with the flow cell and the optical sensor are extensively described, together with the experimental results obtained with an immunoglobulin G (IgG)/anti-IgG assay.
authors: Department of Industrial and Information Engineering, Second University of Naples, Via Roma 29, Aversa 81031, Italy. nunzio.cennamo@unina2.it.
authors: Nunzio
authors: N
authors: Cennamo
authors: Institute of Applied Physics "Nello Carrara", CNR, Via Madonna del Piano 10, Sesto Fiorentino 50019, Italy. f.chiavaioli@ifac.cnr.it.
authors: Francesco
authors: F
authors: Chiavaioli
authors: Institute of Applied Physics "Nello Carrara", CNR, Via Madonna del Piano 10, Sesto Fiorentino 50019, Italy. c.trono@ifac.cnr.it.
authors: Cosimo
authors: C
authors: Trono
authors: Institute of Applied Physics "Nello Carrara", CNR, Via Madonna del Piano 10, Sesto Fiorentino 50019, Italy. s.tombelli@ifac.cnr.it.
authors: Sara
authors: S
authors: Tombelli
authors: Institute of Applied Physics "Nello Carrara", CNR, Via Madonna del Piano 10, Sesto Fiorentino 50019, Italy. a.giannetti@ifac.cnr.it.
authors: Ambra
authors: A
authors: Giannetti
authors: Institute of Applied Physics "Nello Carrara", CNR, Via Madonna del Piano 10, Sesto Fiorentino 50019, Italy. f.baldini@ifac.cnr.it.
authors: Francesco
authors: F
authors: Baldini
authors: Department of Industrial and Information Engineering, Second University of Naples, Via Roma 29, Aversa 81031, Italy. luigi.zeni@unina2.it.
authors: Luigi
authors: L
authors: Zeni
keywords: biosensors; flow cell; plastic optical fiber; sensors system; surface plasmon resonance