title: Targeting Met and VEGFR Axis in Metastatic Castration-Resistant Prostate Cancer: 'Game Over'?
abstract: Despite recent advances that have been made in the therapeutic landscape of metastatic castration-resistant prostate cancer (mCRPC), effective management of bone metastases remains a key goal not yet reached. The receptor tyrosine kinase MET and the vascular endothelial growth factor receptor (VEGFR) seem to play an important role in prostate cancer progression and pathological bone turnover, representing potential targets for improving clinical outcomes in mCRPC. Studies evaluating agents that target one or both these pathways have demonstrated modest activity but no improvement in overall survival. Nevertheless, this therapeutic strategy seems to still be a promising and engaging area of prostate cancer research and the interest in better understanding the MET/VEGFR axis and the mechanism of action of these inhibitors is growing. This review describes the rationale for targeting MET and VEGFR pathway in mCRPC and provides the clinical data available to date and an update on ongoing trials.
authors: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (AOUI), University of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
authors: Alessandra
authors: A
authors: Modena
authors: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (AOUI), University of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy. fmassari79@gmail.com.
authors: Francesco
authors: F
authors: Massari
authors: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (AOUI), University of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
authors: Chiara
authors: C
authors: Ciccarese
authors: Department of Pathology and Diagnostic, Azienda Ospedaliera Universitaria Integrata (AOUI), University of Verona, Verona, Italy.
authors: Matteo
authors: M
authors: Brunelli
authors: Medical Oncology, Azienda Ospedaliera Universitaria (AOU) Ospedali Riuniti, Polytechnic University of the Marche Region, Ancona, Italy.
authors: Matteo
authors: M
authors: Santoni
authors: Section of Pathological Anatomy, School of Medicine, Azienda Ospedaliera Universitaria (AOU) Ospedali Riuniti, Polytechnic University of the Marche Region, Ancona, Italy.
authors: Rodolfo
authors: R
authors: Montironi
authors: Department of Pathology and Diagnostic, Azienda Ospedaliera Universitaria Integrata (AOUI), University of Verona, Verona, Italy.
authors: Guido
authors: G
authors: Martignoni
authors: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (AOUI), University of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
authors: Giampaolo
authors: G
authors: Tortora
mesh_terms: D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000473:pathology; D019859:Proto-Oncogene Proteins c-met; D042461:Vascular Endothelial Growth Factor A
chemical_list: D042461:Vascular Endothelial Growth Factor A; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met