title: CrAgDb--a database of annotated chaperone repertoire in archaeal genomes.
abstract: Chaperones are a diverse class of ubiquitous proteins that assist other cellular proteins in folding correctly and maintaining their native structure. Many different chaperones cooperate to constitute the 'proteostasis' machinery in the cells. It has been proposed earlier that archaeal organisms could be ideal model systems for deciphering the basic functioning of the 'protein folding machinery' in higher eukaryotes. Several chaperone families have been characterized in archaea over the years but mostly one protein at a time, making it difficult to decipher the composition and mechanistics of the protein folding system as a whole. In order to deal with these lacunae, we have developed a database of all archaeal chaperone proteins, CrAgDb (Chaperone repertoire in Archaeal genomes). The data have been presented in a systematic way with intuitive browse and search facilities for easy retrieval of information. Access to these curated datasets should expedite large-scale analysis of archaeal chaperone networks and significantly advance our understanding of operation and regulation of the protein folding machinery in archaea. Researchers could then translate this knowledge to comprehend the more complex protein folding pathways in eukaryotic systems. The database is freely available at http://14.139.227.92/mkumar/cragdb/.
authors: Department of Biophysics, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India.
authors: Shikha
authors: S
authors: Rani
authors: Department of Biophysics, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India.
authors: Abhishikha
authors: A
authors: Srivastava
authors: Department of Biophysics, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India.
authors: Manish
authors: M
authors: Kumar
authors: Department of Biophysics, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India manishagoel@south.du.ac.in.
authors: Manisha
authors: M
authors: Goel
mesh_terms: D019843:Archaeal Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D019295:Computational Biology / Q000379:methods; D030541:Databases, Genetic; D020745:Genome, Archaeal; D018832:Molecular Chaperones / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012984:Software; D014584:User-Computer Interface; D064878:Web Browser
chemical_list: D019843:Archaeal Proteins; D018832:Molecular Chaperones
keywords: aggregation; archaea; chaperones; comparative genomics; protein folding machinery; proteostasis