title: Synthesis of Gold Nanoparticles with Buffer-Dependent Variations of Size and Morphology in Biological Buffers.
abstract: The demand for biologically compatible and stable noble metal nanoparticles (NPs) has increased in recent years due to their inert nature and unique optical properties. In this article, we present 11 different synthetic methods for obtaining gold nanoparticles (Au NPs) through the use of common biological buffers. The results demonstrate that the sizes, shapes, and monodispersity of the NPs could be varied depending on the type of buffer used, as these buffers acted as both a reducing agent and a stabilizer in each synthesis. Theoretical simulations and electrochemical experiments were performed to understand the buffer-dependent variations of size and morphology exhibited by these Au NPs, which revealed that surface interactions and the electrostatic energy on the (111) surface of Au were the determining factors. The long-term stability of the synthesized NPs in buffer solution was also investigated. Most NPs synthesized using buffers showed a uniquely wide range of pH stability and excellent cell viability without the need for further modifications.
authors: Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya Suruga-ku, Shizuoka, 422-8529, Japan. rahin_sust@yahoo.com.
authors: Syed Rahin
authors: SR
authors: Ahmed
authors: Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, 46279, South Korea. ohsj1658@naver.com.
authors: Sangjin
authors: S
authors: Oh
authors: Department of Applied Biological Chemistry, Shizuoka University, 836 Ohya Suruga-ku, Shizuoka, 422-8529, Japan. babamaron11@yahoo.co.jp.
authors: Rina
authors: R
authors: Baba
authors: Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031, P. R. China. hjzhou@issp.ac.cn.
authors: Hongjian
authors: H
authors: Zhou
authors: Department of Nanomechatronics Engineering, Pusan National University, Miryang, 627-706, South Korea. sungu@pusan.ac.kr.
authors: Sungu
authors: S
authors: Hwang
authors: Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, 46279, South Korea. jaebeom@pusan.ac.kr.
authors: Jaebeom
authors: J
authors: Lee
authors: Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya Suruga-ku, Shizuoka, 422-8529, Japan. park.enoch@shizuoka.ac.jp.|Graduate School of Science and Technology, Shizuoka University, 836 Ohya Suruga-ku, Shizuoka, 422-8529, Japan. park.enoch@shizuoka.ac.jp.
authors: Enoch Y
authors: EY
authors: Park
keywords: Cell viability; Gold nanoparticles; Good’s buffer; MD simulation; Synthesis route