title: Curcumin analog L3 alleviates diabetic atherosclerosis by multiple effects.
abstract: L3, an analog of curcumin, is a compound isolated from a traditional Chinese medicine Turmeric. In this paper, we aims to explore the efficacy of L3 on diabetic atherosclerosis and the related mechanism. The effect of L3 was studied on glucose and lipid metabolism, antioxidant status, atherosclerosis-related indexes and pathological changes of main organs in the mice model of diabetes induced by streptozotocin and high-fat diet. The results showed that L3 treatment could meliorate dyslipidemia and hyperglycemia, reduce oxidative stress, enhance the activity of antioxidases, increase the nitric oxide level in plasma and aortic arch, decrease the production of reactive oxygen species in pancreas and lectin-like oxidized low-density lipoprotein receptor-1 expression in aortic arch, and meliorate the fatty and atherosclerotic degeneration in aortic arch, thereby preventing the development of diabetes and its complications. These results suggested that L3 can alleviate the diabetic atherosclerosis by multiple effects. This study provided scientific basis for the further research and clinical application of L3.
authors: Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350004, China; Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fuzhou 350004, China; Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors: Bin
authors: B
authors: Zheng
authors: Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fuzhou 350004, China; Department of Medical Chemistry, School of Pharmacy, Fujian Medical University, Fuzhou 350004, China.
authors: Liu
authors: L
authors: Yang
authors: Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350004, China; Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fuzhou 350004, China.
authors: Caixia
authors: C
authors: Wen
authors: Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350004, China; Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fuzhou 350004, China.
authors: Xiuwang
authors: X
authors: Huang
authors: Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350004, China; Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fuzhou 350004, China; Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors: Chenxia
authors: C
authors: Xu
authors: School of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan.
authors: Kuan-Han
authors: KH
authors: Lee
authors: Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350004, China; Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fuzhou 350004, China. Electronic address: xjh@fjmu.edu.cn.
authors: Jianhua
authors: J
authors: Xu
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D050197:Atherosclerosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D003474:Curcumin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D059305:Diet, High-Fat; D006943:Hyperglycemia / Q000188:drug therapy; D006949:Hyperlipidemias / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D051127:Scavenger Receptors, Class E / Q000378:metabolism
chemical_list: D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; C495138:Olr1 protein, mouse; D017382:Reactive Oxygen Species; D051127:Scavenger Receptors, Class E; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D003474:Curcumin
keywords: Analog of curcumin; Diabetic atherosclerosis; Dyslipidemia; Hyperglycemia; L3