title: Relationship between vitamin D and body fat distribution evaluated by DXA in postmenopausal women.
abstract: OBJECTIVE
  The aim of this study was to explore the relationship between 25-hydroxyvitamin D (25[OH]D) serum concentrations and body fat distribution in a sample of postmenopausal women.
  
  
  METHODS
  We enrolled sixty-two postmenopausal women; 25(OH)D serum concentrations, serum intact parathyroid hormone, blood analyses, and anthropometric measurements were carried out. Body fat composition was evaluated by dual-energy X-ray absorptiometry. Insulin resistance was estimated by homeostatic model assessment of insulin resistance (HOMA-IR) calculation.
  
  
  RESULTS
  Low levels of vitamin D (<30 ng/mL) were found in 77.4% of the population studied. There was a correlation (P < 0.0001) between 25(OH)D and waist circumference (r = -0.543), android fat to gynoid fat (A/G) ratio (r = -0.554), high-density lipoprotein cholesterol (r = 0.498), and HOMA-IR (r = -0.520). A/G fat ratio (B = -34.90; 95% confidence interval [-55.30, -14.1]; P = 0.019), HOMA-IR (B = -3.17; 95% confidence interval [-5.99, -0.351]; P = 0.028), and high-density lipoprotein cholesterol (B = 0.361; 95% confidence interval [0.033, 0.698]; P = 0.032), were found to be independent predictors of lower 25(OH)D by multilogistic regression analysis. Except for waist circumference, both these results were maintained when correlations were adjusted for age, onset of menopause, serum intact parathyroid hormone, and medications, and when body mass index was added as covariate.
  
  
  CONCLUSIONS
  Vitamin D deficiency and insufficiency are common conditions. A/G ratio appeared to be associated with 25(OH)D concentrations and it is well-known that the android disposition of body fat is more closely associated with the onset of metabolic syndrome. Longitudinal studies are needed to better characterize the direction and the causal links of this association.
authors: Predictive Medicine Unit, Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Paola
authors: P
authors: Andreozzi
authors: Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: walter.verrusio@uniroma1.it.
authors: Walter
authors: W
authors: Verrusio
authors: Predictive Medicine Unit, Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Giovanni
authors: G
authors: Viscogliosi
authors: Predictive Medicine Unit, Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Maria Luna
authors: ML
authors: Summa
authors: Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Nicolò
authors: N
authors: Gueli
authors: Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Mauro
authors: M
authors: Cacciafesta
authors: Department of Radiologycal Sciences, Oncology and Anatomo Pathology, "Sapienza" University of Rome, Rome, Italy.
authors: Carlina V
authors: CV
authors: Albanese
mesh_terms: D015502:Absorptiometry, Photon / Q000706:statistics & numerical data*; D050218:Body Fat Distribution / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000096:biosynthesis; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood
chemical_list: D008075:Lipoproteins, HDL; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Body fat distribution; Insulin resistance; Metabolic syndrome; Postmenopausal women; Vitamin D