title: Enzymatic activatable self-assembled peptide nanowire for targeted therapy and fluorescence imaging of tumors.
abstract: We developed novel activatable probe using self-assembled peptide nanowires with low affinity and toxicity to tumor cells in the absence of matrix metalloproteinase that showed activated high affinity and toxicity and provided a highly selective and efficient platform for targeted therapy and tumor imaging.
authors: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. jianhuijiang@hnu.edu.cn zhanwu@hnu.edu.cn.
authors: Ying
authors: Y
authors: Tang
authors: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. jianhuijiang@hnu.edu.cn zhanwu@hnu.edu.cn.
authors: Zhan
authors: Z
authors: Wu
authors: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. jianhuijiang@hnu.edu.cn zhanwu@hnu.edu.cn.
authors: Chong-Hua
authors: CH
authors: Zhang
authors: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. jianhuijiang@hnu.edu.cn zhanwu@hnu.edu.cn.
authors: Xiao-Li
authors: XL
authors: Zhang
authors: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. jianhuijiang@hnu.edu.cn zhanwu@hnu.edu.cn.
authors: Jian-Hui
authors: JH
authors: Jiang
mesh_terms: D045744:Cell Line, Tumor; D005453:Fluorescence; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000737:chemistry*; D053770:Nanowires / Q000737:chemistry*; D009369:Neoplasms / Q000737:chemistry* / Q000188:drug therapy; D061848:Optical Imaging / Q000379:methods*; D010455:Peptides / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D010455:Peptides; D020781:Matrix Metalloproteinase 1