title: The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment.
abstract: Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor microenvironment. The main feature of these cells is their potent immune suppressive activity. MDSC are generated in the bone marrow and, in tumor-bearing hosts, migrate to peripheral lymphoid organs and the tumor to contribute to the formation of the tumor microenvironment. Recent findings have revealed differences in the function and fate of MDSC in the tumor and peripheral lymphoid organs. We review these findings here and, in this context, we discuss the current understanding as to the nature of these differences, the underlying mechanisms, and their potential impact on the regulation of tumor progression.
authors: The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104.
authors: Vinit
authors: V
authors: Kumar
authors: The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104.
authors: Sima
authors: S
authors: Patel
authors: The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104.
authors: Evgenii
authors: E
authors: Tcyganov
authors: The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104.
authors: Dmitry I
authors: DI
authors: Gabrilovich
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D002454:Cell Differentiation; D018925:Chemokines / Q000378:metabolism; D006801:Humans; D007165:Immunosuppression Therapy; D008264:Macrophages / Q000502:physiology*; D000072737:Myeloid-Derived Suppressor Cells / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology*; D059016:Tumor Microenvironment
chemical_list: D018925:Chemokines