title: Effects of Heterogeneous Diffuse Fibrosis on Arrhythmia Dynamics and Mechanism.
abstract: Myocardial fibrosis is an important risk factor for cardiac arrhythmias. Previous experimental and numerical studies have shown that the texture and spatial distribution of fibrosis may play an important role in arrhythmia onset. Here, we investigate how spatial heterogeneity of fibrosis affects arrhythmia onset using numerical methods. We generate various tissue textures that differ by the mean amount of fibrosis, the degree of heterogeneity and the characteristic size of heterogeneity. We study the onset of arrhythmias using a burst pacing protocol. We confirm that spatial heterogeneity of fibrosis increases the probability of arrhythmia induction. This effect is more pronounced with the increase of both the spatial size and the degree of heterogeneity. The induced arrhythmias have a regular structure with the period being mostly determined by the maximal local fibrosis level. We perform ablations of the induced fibrillatory patterns to classify their type. We show that in fibrotic tissue fibrillation is usually of the mother rotor type but becomes of the multiple wavelet type with increase in tissue size. Overall, we conclude that the most important factor determining the formation and dynamics of arrhythmia in heterogeneous fibrotic tissue is the value of maximal local fibrosis.
authors: Department of Physics and Astronomy, Ghent University, Ghent, Belgium.
authors: Ivan V
authors: IV
authors: Kazbanov
authors: Department of Biology, Utrecht University, Utrecht, the Netherlands.
authors: Kirsten H W J
authors: KH
authors: ten Tusscher
authors: Department of Physics and Astronomy, Ghent University, Ghent, Belgium.|Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russia.
authors: Alexander V
authors: AV
authors: Panfilov
mesh_terms: D000465:Algorithms; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D009202:Cardiomyopathies / Q000150:complications* / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D008954:Models, Biological