title: The association between MR T1ρ and T2 of cartilage and patient-reported outcomes after ACL injury and reconstruction.
abstract: To determine if cartilage T1ρ and T2 relaxation time measures after ACL injury and prior to reconstruction (baseline) are associated with patient-reported outcomes at baseline, 6-months, and 1-year after surgery.
  
  
  
  Fifty-four ACL-injured participants were scanned in both knees at baseline using 3T MR T1ρ and T2 mapping. Participants also completed Knee-injury and Osteoarthritis Outcome Score (KOOS) and Marx activity level questionnaires at baseline, 6-months, and 1-year after reconstruction. The difference between cartilage T1ρ or T2 of the injured and contralateral knee (side-to-side difference, SSD) was calculated to account for physiological variations among patients. Linear regression models were built to evaluate the association between the baseline SSD T1ρ or T2 and KOOS or Marx at all time points.
  
  
  
  Higher baseline SSD T1ρ posterolateral tibia (pLT) was associated with worse KOOS in all subscales except symptoms at baseline, worse KOOS pain at 6-months, and worse KOOS in all subscales except sports function at 1-year. Higher baseline SSD T2 femoral trochlea (TrF) was associated with worse KOOS activities of daily living (ADL) at 1-year. Higher baseline SSD T1ρ pLT was associated with lower Marx activity level at 1-year. More severe cartilage lesions, as assessed by Whole-Organ MRI Scoring (WORMS), was significantly associated with worse KOOS pain at 6-months and 1-year.
  
  
  
  T1ρ and T2 of cartilage after ACL injury were associated with KOOS after injury and both KOOS and Marx after reconstruction. Such associations may help clinicians stratify outcomes post-injury, and thus, improve patient management.
authors: Musculoskeletal Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, UC San Francisco, San Francisco, CA, USA. Electronic address: favian.su@pitt.edu.
authors: F
authors: F
authors: Su
authors: Musculoskeletal Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, UC San Francisco, San Francisco, CA, USA. Electronic address: valentina.pedoia@ucsf.edu.
authors: V
authors: V
authors: Pedoia
authors: Musculoskeletal Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, UC San Francisco, San Francisco, CA, USA. Electronic address: hsiang-ling.teng@ucsf.edu.
authors: H-L
authors: HL
authors: Teng
authors: Musculoskeletal Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, UC San Francisco, San Francisco, CA, USA. Electronic address: martin.kretzschmar@ucsf.edu.
authors: M
authors: M
authors: Kretzschmar
authors: Department of Orthopaedic Surgery, UC San Francisco, San Francisco, CA, USA. Electronic address: brian.lau@ucsf.edu.
authors: B C
authors: BC
authors: Lau
authors: Department of Epidemiology and Biostatistics, UC San Francisco, San Francisco, CA, USA. Electronic address: charles.mcculloch@ucsf.edu.
authors: C E
authors: CE
authors: McCulloch
authors: Musculoskeletal Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, UC San Francisco, San Francisco, CA, USA. Electronic address: thomas.link@ucsf.edu.
authors: T M
authors: TM
authors: Link
authors: Department of Orthopaedic Surgery, UC San Francisco, San Francisco, CA, USA. Electronic address: maben@ucsf.edu.
authors: C B
authors: CB
authors: Ma
authors: Musculoskeletal Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, UC San Francisco, San Francisco, CA, USA. Electronic address: xiaojuan.li@ucsf.edu.
authors: X
authors: X
authors: Li
mesh_terms: D000203:Activities of Daily Living; D000070598:Anterior Cruciate Ligament Injuries; D059549:Anterior Cruciate Ligament Reconstruction; D006801:Humans; D007718:Knee Injuries; D000071066:Patient Reported Outcome Measures
keywords: ACL reconstruction; Cartilage; KOOS; Marx activity rating scale; T1ρ; T2