title: Neuroprotection by Polynitrogen Manganese Complexes: Regulation of Reactive Oxygen Species-Related Pathways.
abstract: Cell death in the central nervous system causes neurologic diseases, in which reactive oxygen species (ROS) play a critical role by either inducing cellular oxidative stress or by increasing the cell tolerance against insult. Neurologic diseases may potentially be treated by regulating ROS levels in a certain range with small molecules. We studied preconditioning with two polynitrogen manganese complexes (1 and 2) to regulate intracellular ROS levels in the protection of both the differentiated rat pheochromocytoma cell line (PC12 cells) and neurons against H2O2-induced apoptosis. Pre-treatment with the two complexes attenuated the cell apoptosis caused by H2O2. And the ROS-related neuroprotective mechanisms were explored. Both complexes activate the hypoxia inducible factor-related pathways and increase the cell adaptation to oxidative stress. Pre-treatment with complex 1 eliminated intracellular ROS, which also activated antioxidase system, while short-term incubation of complex 2, generated low levels of ROS leading to cell survival.
authors: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, P.R. China.
authors: Chunxia
authors: C
authors: Chen
authors: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, P.R. China.
authors: Jing
authors: J
authors: Cao
authors: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, P.R. China.
authors: Xiaoyan
authors: X
authors: Ma
authors: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, P.R. China.
authors: Xiaobo
authors: X
authors: Wang
authors: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P.R. China.
authors: Qiuyun
authors: Q
authors: Chen
authors: Department of Pharmacology, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, P.R. China.
authors: Shihai
authors: S
authors: Yan
authors: Department of Pharmacology, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, P.R. China.|Biomedical Research Laboratory, Shimadzu (China) Co., Ltd, Shanghai 200052, P.R. China.
authors: Ningwei
authors: N
authors: Zhao
authors: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, P.R. China.
authors: Zhirong
authors: Z
authors: Geng
authors: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, P.R. China.
authors: Zhilin
authors: Z
authors: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D017895:Manganese Compounds / Q000494:pharmacology*; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016716:PC12 Cells; D051381:Rats
chemical_list: D017895:Manganese Compounds; D018696:Neuroprotective Agents; D006861:Hydrogen Peroxide