title: An Overview of Non-Neural Sources of Calcitonin Gene-Related Peptide.
abstract: Calcitonin gene-related peptide (CGRP) is extensively distributed throughout the central and peripheral nervous systems and has been shown to be a 37 amino acid multifunctional neuropeptide involved in a wide range of physiological and pathological processes. Recently, there is increasing evidence suggesting that CGRP also exists in non-nerve cells, such as epithelial cells, endothelial cells, endothelial progenitor cells (EPCs), T lymphocytes, B lymphocytes, peripheral blood mononuclear cells (PBMCs), and adipocytes. The existence of CGRP in non-neural tissue is of great importance to the regulation of multiple physiological and pathological processes via different pathways, especially through an autocrine/paracrine mode. This review integrates evidence from recent developments and aims to provide novel insights into non-neural sources of CGRP and its effects on physiological and pathological processes.
authors: Rong
authors: R
authors: Hu
authors: Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha 410078, China. yuan_jianli@yahoo.com.
authors: Yuan-Jian
authors: YJ
authors: Li
authors: Xiao-Hui
authors: XH
authors: Li
mesh_terms: D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*
chemical_list: D015740:Calcitonin Gene-Related Peptide