title: Histological Study of Bone Marrow and Umbilical Cord Stromal Cell Transplantation in Regenerating Rat Peripheral Nerve.
abstract: OBJECTIVE
  Bone marrow and umbilical cord stromal cells are multipotential stem cells that have the ability to produce growth factors that play an important role in survival and generation of axons. The goal of this study was to evaluate the effects of the two different mesenchymal stem cells on peripheral nerve regeneration.
  
  
  METHODS
  In this experimental study, a 10 mm segment of the left sciatic nerve of male Wistar rats (250-300 g) was removed with a silicone tube interposed into this nerve gap. Bone marrow stromal cells (BMSCs) and human umbilical cord stromal cells (HUCSCs) were respectively obtained from rat and human. The cells were sepa- rately cultured and transplanted into the nerve gap. The sciatic nerve regeneration was evaluated by immunohistochemistry, and light and electron microscopy. Moreover, histo- morphology of the gastrocnemius muscle was observed.
  
  
  RESULTS
  The nerve regeneration in the BMSCs and HUCSCs groups that had received the stem cells was significantly more favorable than the control group. In addition, the BM- SCs group was significantly more favorable than the HUCSCs group (P<0.05).
  
  
  CONCLUSIONS
  The results of this study suggest that both homograft BMSCs and het- erograft HUCSCs may have the potential to regenerate peripheral nerve injury and transplantation of BMSCs may be more effective than HUCSCs in rat.
authors: Research Center of Nervous System Stem Cells, Department of Anatomy, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
authors: Sam
authors: S
authors: Zarbakhsh
authors: Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors: Nasim
authors: N
authors: Goudarzi
authors: Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors: Maryam
authors: M
authors: Shirmohammadi
authors: Research Center of Nervous System Stem Cells, Department of Anatomy, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
authors: Manouchehr
authors: M
authors: Safari
keywords: Bone Marrow Stromal Cells; Human Umbilical Cord Stromal Cells; Peripheral Nerve; Regeneration; Trans- plantation