title: Hepatitis C Virus-Associated B-Cell Non-Hodgkin's Lymphoma: Clinical and Therapeutic Challenges.
abstract: Hepatitis C virus (HCV) is a major cause of liver-related morbidity and is strongly associated with B-cell lymphoproliferative disorders. Data from epidemiological, biological and clinical investigations support the hypothesis of a pathogenetic role of HCV in at least a subgroup of patients with B-cell non-Hodgkin's lymphoma (B-NHL). Morphologically, HCV-associated B-NHL represents a variety of histological subtypes. The comprehension of the mechanisms of HCV persistence and of its role in the lymphomagenesis will be useful to set new strategies with the aim to prevent and treat HCV-associated B-NHLs. This hypothesis of a virus-induced mechanism of lymphomagenesis arises from the growing evidence that successful antiviral treatment is often linked to regression of some types of HCV-related indolent B-NHLs.
authors: Liver Unit, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy.
authors: Sabino
authors: S
authors: Russi
authors: Azienda Ospedaliera "Mellino Mellini", Chiari (BS), Italy.
authors: Loredana
authors: L
authors: Sansonno
authors: Liver Unit, Department of Internal Medicine and Human Oncology, University of Bari Medical School, Policlinico - Piazza Giulio Cesare, 11 - 70124 Bari, Italy.
authors: Domenico
authors: D
authors: Sansonno
mesh_terms: D004194:Disease; D014644:Genetic Variation; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics* / Q000502:physiology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000453:epidemiology; D054884:Host-Pathogen Interactions; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000821:virology*
keywords: B-cell non-hodgkin’s lymphoma; Hepatitis C virus; lymphomagenesis; lymphoproliferation; mixed cryoglobulinemia; vasculitis