title: [Stability of high-dose etoposide dilutions for use in hematopoietic stem cell transplantation conditioning regimens].
abstract: High-dose etoposide is used in conditioning regimens for allogeneic stem cell transplantation. The limited stability of the drug induces barriers for its use for pharmacists, nurses and patients. When using a concentration of 10 mg/mL etoposide in physiologic saline, limitations can be overcome. This study provides stability data for etoposide in a high concentration that can be used in conditioning regimens. The solution was stable for 48h at 5°C, for 48h at 5°C followed by 8h at 25°C and for 24 h at 25°C.
authors: T
authors: T
authors: Bauters
authors: J
authors: J
authors: Vandenbroucke
authors: S
authors: S
authors: Commeyne
mesh_terms: D000328:Adult; D004339:Drug Compounding; D005047:Etoposide / Q000737:chemistry* / Q000494:pharmacology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D059005:Topoisomerase II Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D019172:Transplantation Conditioning / Q000379:methods*
chemical_list: D059005:Topoisomerase II Inhibitors; D005047:Etoposide