title: Analysis of genetic admixture in Uyghur using the 26 Y-STR loci system.
abstract: The Uyghur population has experienced extensive interaction with European and Eastern Asian populations historically. A set of high-resolution genetic markers could be useful to infer the genetic relationships between the Uyghur population and European and Asian populations. In this study we typed 100 unrelated Uyghur males living in southern Xinjiang at 26 Y-STR loci. Using the high-resolution 26 Y-STR loci system, we investigated genetic and phylogenetic relationship between the Uyghur population and 23 reference European or Asian populations. We found that the Uyghur population exhibited a genetic admixture of Eastern Asian and European populations, and had a slightly closer relationship with the selected European populations than the Eastern Asian populations. We also demonstrated that the 26 Y-STR loci system was potentially useful in forensic sciences because it has a large power of discrimination and rarely exhibits common haplotypes. However, ancestry inference of Uyghur samples could be challenging due to the admixed nature of the population.
authors: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, China.
authors: Yingnan
authors: Y
authors: Bian
authors: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, China.|State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China.
authors: Suhua
authors: S
authors: Zhang
authors: University of Pennsylvania, 3451 Walnut Street, Philadelphia, PA 19104, United States.
authors: Wei
authors: W
authors: Zhou
authors: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, China.|Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China.
authors: Qi
authors: Q
authors: Zhao
authors: Shihezi City Public Security Bureau Traffic Institute of Science and Technology, Xinjiang 832000, China.
authors: Siqintuya
authors: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, China.
authors: Ruxin
authors: R
authors: Zhu
authors: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, China.
authors: Zheng
authors: Z
authors: Wang
authors: Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China.
authors: Yuzhen
authors: Y
authors: Gao
authors: Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Institution of Digestive Disease; Key Laboratory of Gastroenterology and Hepatology, Ministry of Health; State Key Laboratory of Oncogene and Related Genes, Shanghai Jiao-Tong University School of Medicine, Shanghai 200001, China.
authors: Jie
authors: J
authors: Hong
authors: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China.
authors: Daru
authors: D
authors: Lu
authors: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, China.
authors: Chengtao
authors: C
authors: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D041322:Chromosomes, Human, Y / Q000145:classification / Q000235:genetics*; D016002:Discriminant Analysis; D053803:Forensic Genetics; D005787:Gene Frequency; D056426:Genetic Loci; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D010802:Phylogeny; D044465:White People / Q000235:genetics