title: Immune status does not predict high-risk HPV in anal condyloma.
abstract: BACKGROUND
  More than 90% of anal condyloma is attributed to nonhigh risk strains of human papillomavirus (HPV), thus patients with anal condyloma do not necessarily undergo HPV serotyping unless they are immunocompromised (IC). We hypothesized that IC patients with anal condyloma have a higher risk of high-risk HPV and dysplasia than nonimmunocompromised (NIC) patients.
  
  
  METHODS
  We performed a retrospective chart review of patients who underwent surgical treatment by a single surgeon for anal condyloma from 1/2000 to 1/2012. HPV serotyping was performed on all patient samples. We compared incidence of high-risk HPV and dysplasia in condyloma specimens from IC and NIC patients.
  
  
  RESULTS
  High-risk HPV was identified in 14 specimens with serotypes 16, 18, 31, 33, 51, 52, and 67. Twenty-two cases (18.3%) had dysplasia. Invasive carcinoma was identified in one IC patient. The prevalence of dysplasia or high-risk HPV was not significantly different between IC and NIC groups. High-risk HPV was a significant independent predictor of dysplasia (odds ratio [OR] = 5.2; 95% CI = 1.24-21.62). Immune status, however, was not a significant predictor of high-risk HPV (OR = 1.11; 95% CI = 0.16-5.12) nor dysplasia (OR = 0.27; 95% CI = 0.037-1.17).
  
  
  CONCLUSIONS
  IC patients did not have a significantly higher prevalence or risk of high-risk HPV or dysplasia in our study. HPV typing of all condylomata, regardless of immune status, should be considered as it may help predict risk of neoplastic transformation or identify NIC patients with an increased risk of developing anal intraepithelial neoplasia.
authors: Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis, Minnesota. Electronic address: leex1203@umn.edu.
authors: Janet T
authors: JT
authors: Lee
authors: Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.
authors: Stanley M
authors: SM
authors: Goldberg
authors: Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.
authors: Robert D
authors: RD
authors: Madoff
authors: Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.
authors: Patrick S
authors: PS
authors: Tawadros
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000276:immunology / Q000821:virology*; D003218:Condylomata Acuminata / Q000276:immunology / Q000821:virology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D011230:Precancerous Conditions / Q000276:immunology / Q000821:virology*; D012189:Retrospective Studies; D055815:Young Adult
keywords: Anal condyloma; Dysplasia; Genital warts; HPV