title: [Cost-effectiveness of consolidation treatments for acute myeloid leukemia in high-risk pediatric patients within the Colombian healthcare system].
abstract: BACKGROUND
  Acute myeloid leukemia represents about 20% of leukemias in minors under 18 years old. At present, there are only two consolidation treatment alternatives: Chemotherapy and stem-cell transplantation.
  
  
  OBJECTIVE
  To evaluate the cost-effectiveness of unrelated and related hematopoietic stem cell transplantations, versus chemotherapy consolidation in pediatric patients with high-risk acute myeloid leukemia.
  
  
  METHODS
  A decision tree was constructed with life-years gained as the outcome. Costs and probabilities were extracted from the literature. Probabilistic sensitivity analyses and acceptability curves were computed. The cost-effectiveness threshold was three times the 2010 per capita gross domestic product.
  
  
  RESULTS
  When compared to consolidation chemotherapy cycles, related and unrelated hematopoietic stem-cell transplantation had incremental cost-effectiveness ratios of COP$ 9,226,421 (USD$ 4,820) and COP$ 6,544,116 (USD$ 3,419) respectively, which are lower than the per capita gross domestic product (COP$ 12,047,418, USD$ 6,294). Transplant proved to be cost-effective in 70% of the simulations and had a higher probability of the willingness to pay being over than COP$ 7,200,000 (USD$ 3,762).
  
  
  CONCLUSIONS
  In Colombia, related and unrelated hematopoietic stem-cell transplants are cost-effective alternatives to consolidation treatment for high-risk acute myeloid leukemia in pediatric patients.
authors: Facultad de Ciencias Económicas, Universidad Nacional de Colombia, Bogotá, D.C, Colombia.
authors: Mario
authors: M
authors: García
authors: Facultad de Ciencias Económicas, Universidad Nacional de Colombia, Bogotá, D.C, Colombia.
authors: Liliana Alejandra
authors: LA
authors: Chicaíza
authors: Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, D.C, Colombia.
authors: Hoover
authors: H
authors: Quitián
authors: Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C, Colombia.
authors: Adriana
authors: A
authors: Linares
authors: Centro Médico Imbanaco, Unidad de Trasplante de Médula Ósea, Cali, Colombia.
authors: Óscar
authors: Ó
authors: Ramírez
mesh_terms: D000293:Adolescent; D064591:Allografts / Q000191:economics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000191:economics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003105:Colombia; D003131:Combined Modality Therapy; D003198:Computer Simulation; D060830:Consolidation Chemotherapy / Q000191:economics*; D003362:Cost-Benefit Analysis; D003663:Decision Trees; D018380:Hematopoietic Stem Cell Transplantation / Q000191:economics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000191:economics* / Q000628:therapy; D018803:Models, Economic; D012306:Risk