title: Midterm Patency After Femoropopliteal Interventions: A Comparison of Standard and Interwoven Nitinol Stents and Drug-Coated Balloons in a Single-Center, Propensity Score-Matched Analysis.
abstract: OBJECTIVE
  To describe and compare primary patency rates in patients undergoing endovascular femoropopliteal interventions with standard or interwoven nitinol stents or drug-coated balloons.
  
  
  METHODS
  A cohort of 1292 patients was treated for symptomatic femoropopliteal occlusive disease classified as Rutherford category ≥ 1 at a large vascular center between June 2006 and August 2013 using either standard nitinol stents (SNS; n=432), interwoven nitinol stents (INS; n=470), or drug-coated balloons (DCB; n=390). Primary patency rates were assessed by ultrasound or angiographic readings for over 3 years of follow-up. Propensity score-matched pairs were formed to compare each treatment with another using survival analysis.
  
  
  RESULTS
  Survival curves of primary patency favored INS compared with SNS in 368 propensity score-matched pairs (p<0.001). Kaplan-Meier estimates at 1, 2, and 3 years were 86.6%, 76.4%, and 68.9%, respectively, in the INS group vs 60.5%, 46.1%, and 42.1%, respectively, in the SNS group. No significant difference (p=0.232) was seen for the comparison of SNS vs DCB in 284 matched pairs over long-term follow-up (primary patency estimates at 1, 2, and 3 years were 79.8%, 53.8%, and 32.9%, respectively, in the DCB group vs 60.5%, 44.8%, and 40.3%, respectively, in the SNS group). Survival curves of primary patency favored INS over DCB in 254 matched pairs (p<0.001). Kaplan-Meier estimates at 1, 2, and 3 years were 79.0%, 51.2%, and 30.1%, respectively, in the DCB group vs 89.0%, 76.9%, and 66.2%, respectively, in the INS group.
  
  
  CONCLUSIONS
  Propensity score-based analysis of primary patency suggests profound differences in restenosis rates between various treatment modalities for femoropopliteal disease for over 3 years of follow-up.
authors: Department of Interventional Angiology, Medical Faculty, University of Leipzig, Germany sabine.steiner@yahoo.com.
authors: Sabine
authors: S
authors: Steiner
authors: Department of Interventional Angiology, Medical Faculty, University of Leipzig, Germany.
authors: Andrej
authors: A
authors: Schmidt
authors: Department of Interventional Angiology, Medical Faculty, University of Leipzig, Germany.
authors: Yvonne
authors: Y
authors: Bausback
authors: Cardiovascular Center Bethanien, Frankfurt, Germany.
authors: Michael
authors: M
authors: Piorkowski
authors: Department of Angiology, Hanusch Hospital, Vienna, Austria.
authors: Martin
authors: M
authors: Werner
authors: Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany.
authors: Maryam
authors: M
authors: Yahiaoui-Doktor
authors: Department of Interventional Angiology, Medical Faculty, University of Leipzig, Germany.
authors: Ursula
authors: U
authors: Banning-Eichenseer
authors: Department of Interventional Angiology, Medical Faculty, University of Leipzig, Germany.
authors: Dierk
authors: D
authors: Scheinert
mesh_terms: D000368:Aged; D000497:Alloys; D016009:Chi-Square Distribution; D020099:Coated Materials, Biocompatible; D003251:Constriction, Pathologic; D016208:Databases, Factual; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D005858:Germany; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D057216:Propensity Score; D016016:Proportional Hazards Models; D012008:Recurrence; D012307:Risk Factors; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D062666:Vascular Access Devices; D014654:Vascular Patency
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; C013616:nitinol
keywords: drug-coated balloon; drug-eluting balloon; femoropopliteal segment; nitinol stent; patency; popliteal artery; propensity score matching; restenosis; superficial femoral artery