title: Glioblastoma in long-term survivors of acute lymphoblastic leukemia: Report of two cases.
abstract: Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children. Second neoplasms as late effects of therapy for ALL have been recognized as a significant clinical issue given the increasing number of long-term survivors of ALL, because they can be the cause of death in such cases. In contrast, glioblastoma (GBM) is the most common primary brain tumor in adults. It is a malignant brain tumor that most often occurs in elderly patients, and GBM in young adults or adolescents appears to be rare. Here, we describe our experience of two cases of GBM in young long-term survivors of ALL, and emphasize the necessity of careful follow up of patients treated for ALL for the potential occurrence of central nervous system second neoplasms, especially when the patients have previously undergone cranial radiotherapy.
authors: Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.|Qingdao Municipal Hospital, Qingdao, China.
authors: Zi
authors: Z
authors: Wang
authors: Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors: Yuzo
authors: Y
authors: Terakawa
authors: Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors: Hiroyuki
authors: H
authors: Goto
authors: Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors: Naohiro
authors: N
authors: Tsuyuguchi
authors: Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors: Hidetoshi
authors: H
authors: Sato
authors: Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors: Junya
authors: J
authors: Abe
authors: Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors: Kenji
authors: K
authors: Ohata
keywords: acute lymphoblastic leukemia; glioblastoma; late effect; second neoplasm