title: Impact of the Increased Recommended Dosage of Isoniazid on Pyridoxine Levels in Children and Adolescents.
abstract: Isoniazid exposure causes dose-dependent pyridoxine deficiency. Recently, the recommended dosage of isoniazid in children was increased from 5 (4-6) to 10 (10-15) mg/kg/day. We aimed to analyze longitudinally pyridoxine levels in a cohort of previously healthy children and adolescents treated with isoniazid. Mild symptom-free pyridoxine deficiency was observed in 4/75 (5.6%) and 3/40 (7.5%) at baseline and at 3-month follow-up, respectively. Classical age-related risk factors identified patients at risk of pyridoxine deficiency. Our preliminary results support current recommendations regarding pyridoxine supplementation in healthy children.
authors: From the *Infectious Diseases Unit, Pediatrics Department, and †Pediatric Tuberculosis Unit, Nursing Department, Hospital Sant Joan de Déu-Universitat de Barcelona, Barcelona, Spain; and ‡Department of Biochemistry and Inborn Errors of Metabolism, Hospital Sant Joan de Déu and CIBERER-ISCIII, Barcelona, Spain.
authors: Diana
authors: D
authors: Rodà
authors: Librada
authors: L
authors: Rozas
authors: Clàudia
authors: C
authors: Fortuny
authors: Cristina
authors: C
authors: Sierra
authors: Antoni
authors: A
authors: Noguera-Julian
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage* / Q000009:adverse effects*; D008137:Longitudinal Studies; D008297:Male; D011736:Pyridoxine / Q000097:blood*; D026681:Vitamin B 6 Deficiency / Q000139:chemically induced* / Q000453:epidemiology*
chemical_list: D000995:Antitubercular Agents; D011736:Pyridoxine; D007538:Isoniazid