title: ADAMTS-18 in the host tissues exerts little effect on breast tumor progress in a murine 4T1 breast cancer model.
abstract: BACKGROUND
  In this study, we aimed to identify a novel extracellular proteinase ADAMTS-18 that could be a potential tumor suppressor gene.
  
  
  RESULTS
  We successfully constructed Adamts-18 knockout mice with BALB / c background. RT-PCR analysis showed syngeneic mammary tumor cell line 4 T1 per se has weakly endogenous ADAMTS-18 expression. Orthotopic inoculation of 4 T1 cells within the mammary fat pad of host mice, we found no significant difference in tumor growth and metastasis between Adamts-18 knockout mice and widetype control.
  
  
  CONCLUSIONS
  We did not confirm that ADAMTS-18 in the host tissues is relevant for breast tumor progress in a murine 4 T1 breast cancer model.
authors: Key Laboratory of Brain Functional Genomics (East China Normal University), Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (East China Normal University), School of Life Science, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China. minliu920120@163.com.
authors: Min
authors: M
authors: Liu
authors: Key Laboratory of Brain Functional Genomics (East China Normal University), Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (East China Normal University), School of Life Science, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China. tianmissing@sina.com.
authors: Tiantian
authors: T
authors: Lu
authors: Key Laboratory of Brain Functional Genomics (East China Normal University), Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (East China Normal University), School of Life Science, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China. fangjing@126.com.
authors: Fang
authors: F
authors: Jing
authors: Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 20025, China. suyindang@shsmu.edu.cn.
authors: Suying
authors: S
authors: Dang
authors: Key Laboratory of Brain Functional Genomics (East China Normal University), Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (East China Normal University), School of Life Science, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China. wzhang@sat.ecnu.edu.cn.
authors: Wei
authors: W
authors: Zhang
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism*; D000071096:ADAMTS Proteins; D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D018450:Disease Progression; D051379:Mice
chemical_list: D051722:ADAM Proteins; D000071096:ADAMTS Proteins; C510099:ADAMTS18 protein, human