title: Bone regeneration in rat femoral defects after osteotomy with surgical ultrasound.
abstract: To evaluate bone healing after osteotomy by surgical drill (D) and piezoelectric ultrasound (U), Wistar rats were submitted to femoral osteotomy and submitted to histological analysis. After 60 h, slight (83.3%) and moderate (3.4%) inflammatory areas were frequent in the U defects whereas D group presented moderate (33.3%) and severe (16.6%) inflammatory infiltrate (P<0.001). There was few intramedullary hemorrhaging in U (80%) than D group (100%, P<0.05). On the 7th day, inflammatory areas was less frequent in U (30%) than D osteotomies (93.4%) (P<0.005) and D osteotomies presented larger areas of ossification (median: 47%, quartile: 37-64%) than U group (30%, 18.5-38%; P<0.005). After 30 days, ossification was larger in the U defects (65.9±10.1%) than D group (57±14.5%, P<0.05). There was complete bone remodeling in both groups after 60 days. Piezoelectric ultrasound evokes less postoperative inflammatory response, but delay initial bone ossification.
authors: Department of Oral Medicine and Pediatric Dentistry, Health Sciences Center, State University of Londrina, Paraná, Brasil - beatrizpedriali@gmail.com.
authors: Maria B
authors: MB
authors: Bergonse Pereira Pedriali
authors: Wilson
authors: W
authors: Trevisan Junior
authors: Fabio
authors: F
authors: Goulart de Andrade
authors: João P
authors: JP
authors: Menck Sangiorgio
authors: William
authors: W
authors: Ricardo Pires
authors: Solange
authors: S
authors: De Paula Ramos
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D016723:Bone Remodeling; D005269:Femur / Q000502:physiology / Q000601:surgery*; D008297:Male; D010000:Osteitis / Q000209:etiology; D010027:Osteotomy / Q000295:instrumentation / Q000379:methods*; D059745:Piezosurgery / Q000009:adverse effects; D011183:Postoperative Complications / Q000209:etiology; D019106:Postoperative Hemorrhage / Q000209:etiology; D051381:Rats; D017208:Rats, Wistar