title: [Interaction of Membrane and Calcium Oscillators in Cardiac Pacemaker Cells: Mathematical Modeling].
abstract: An integrative model of the calcium dynamics in cardiac pacemaker cells is developed taking into account a synergetic effect of the interaction between an outer membrane oscillator and an intracellular calcium oscillator ("membrane and Ca(2+)-clock"). The main feature of the model is a description of the stochastic dynamics of Ca2+ release units within the electron-conformational mechanism of the functioning of ryanodine-sensitive calcium channels. It is shown that interaction of two cellular oscillators provides a stable action potential generation in the cardiac pacemaker cells even in the case of the stochastic Ca2+ dynamics. We studied in detail the effect of ryanodine channels sensitivity to an increase in the intracellular calcium concentration in sarcoplasmic reticulum and in the dyadic space on the behavior of calcium-release system. A parametric analysis of the integrative model of pacemaker cells is performed.
authors: A M
authors: AM
authors: Ryvkin
authors: N M
authors: NM
authors: Zorin
authors: A S
authors: AS
authors: Moskvin
authors: O E
authors: OE
authors: Solovyova
authors: V S
authors: VS
authors: Markhasin
mesh_terms: D000200:Action Potentials; D000818:Animals; D001683:Biological Clocks; D002118:Calcium / Q000737:chemistry / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology; D008566:Membranes / Q000737:chemistry / Q000378:metabolism; D008962:Models, Theoretical; D032383:Myocytes, Cardiac / Q000737:chemistry / Q000378:metabolism*; D010138:Pacemaker, Artificial; D019837:Ryanodine Receptor Calcium Release Channel / Q000737:chemistry* / Q000378:metabolism
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium