title: T Cells and Cancer: How Metabolism Shapes Immunity.
abstract: Tumor microenvironment is characterized by a consistent reduction in oxygen and blood-borne nutrients that significantly affects the metabolism of distinct cell subsets. Immune cells populating malignant lesions need to activate alternative pathways to overcome tumor-prolonged nutrient deprivation. In particular, the metabolic switch occurring in transforming tissues dramatically impacts on tumor-infiltrating T cell biology. Remarkably, the recruitment and activation of T cell within cancers are instrumental for effective antitumor response. Therefore, T cell metabolic adaptation acts as crucial checkpoint hijacked by tumors to dampen antitumor immunity.
authors: Department of Biomedical Sciences, University of Padua, Padua, Italy; Venetian Institute of Molecular Medicine (VIMM), Padova, Italy.
authors: Barbara
authors: B
authors: Molon
authors: Department of Biomedical Sciences, University of Padua, Padua, Italy; Venetian Institute of Molecular Medicine (VIMM), Padova, Italy.
authors: Bianca
authors: B
authors: Calì
authors: Department of Biomedical Sciences, University of Padua, Padua, Italy; Venetian Institute of Molecular Medicine (VIMM), Padova, Italy.
authors: Antonella
authors: A
authors: Viola
keywords: T lymphocyte activation; immune escape; immunotherapy; reactive nitrogen species; tumor microenvironment