title: Letter: Supermetallization of peptides and proteins with tetravalent metal Th(IV).
abstract: Supermetallization is the recently observed phenomenon of the formation of complex ions of peptide-metal in the gas phase when the peptide accepts an unexpectedly large number of metal atoms. It has been found that supermetallization takes place during electrospray ionization when charged droplets are evaporating at relatively high temperature (ca 400°C). In the present paper, we demonstrate supermetallized complexes of small protein ubiquitin and two peptides with Th(IV). We have observed complexes of ubiquitin with up to five thorium atoms, and attaching each Th(IV) requires the removal of four hydrogen atoms. To our knowledge, this is the first demonstration of gas-phase complexes of peptides and proteins with tetravalent metal atoms..
authors: Skolkovo Institute of Science and Technology Novaya St., 100, Skolkovo 143025 Russian Federation. Institute for Energy Problems of Chemical Physics Russian Academy of Sciences Leninskij pr. 38 k.2, 119334 Moscow, Russia. Emanuel Institute for Biochemical Physics Russian Academy of Sciences Kosygina st. 4, 119334 Moscow, Russia. Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russia.. yura542@rambler.ru.
authors: Yury
authors: Y
authors: Kostyukevich
authors: Institute for Energy Problems of Chemical Physics Russian Academy of Sciences Leninskij pr. 38 k.2, 119334 Moscow, Russia. Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russia.. konoleha@yandex.ru.
authors: Alexey
authors: A
authors: Kononikhin
authors: Institute for Energy Problems of Chemical Physics Russian Academy of Sciences Leninskij pr. 38 k.2, 119334 Moscow, Russia. Emanuel Institute for Biochemical Physics Russian Academy of Sciences Kosygina st. 4, 119334 Moscow, Russia. Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russia.. kukaev@mail.ru.
authors: Eugene
authors: E
authors: Kukaev
authors: Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan. jetea@fac.nsysu.edu.tw.
authors: Jentaie
authors: J
authors: Shiea
authors: Emanuel Institute for Biochemical Physics Russian Academy of Sciences Kosygina st. 4, 119334 Moscow, Russia. Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russia.. hexapole@gmail.com.
authors: Igor
authors: I
authors: Popov
authors: Skolkovo Institute of Science and Technology Novaya St., 100, Skolkovo 143025 Russian Federation. Institute for Energy Problems of Chemical Physics Russian Academy of Sciences Leninskij pr. 38 k.2, 119334 Moscow, Russia. Emanuel Institute for Biochemical Physics Russian Academy of Sciences Kosygina st. 4, 119334 Moscow, Russia. Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russia.. ennikolaev@rambler.ru.
authors: Eugene
authors: E
authors: Nikolaev
mesh_terms: D005740:Gases / Q000737:chemistry; D006859:Hydrogen; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013910:Thorium / Q000737:chemistry*
chemical_list: D005740:Gases; D010455:Peptides; D011506:Proteins; D013910:Thorium; D006859:Hydrogen