title: Genetic Risk Factors for Psoriasis in Turkish Population: -1540 C/A, -1512 Ins18, and +405 C/G Polymorphisms within the Vascular Endothelial Growth Factor Gene.
abstract: BACKGROUND
  Evidence regarding the vascular endothelial growth factor A (VEGFA) as a potent mediator of angiogenesis and inflammation in psoriasis has revealed variations in this gene as surrogate markers of psoriasis.
  
  
  OBJECTIVE
  VEGFA gene polymorphisms (-1540 C/A, -1512 Ins18, -460 T/C, and +405 C/G) in psoriasis susceptibility in Turkish population were investigated.
  
  
  METHODS
  A total of 200 age, sex and ethnicity-matched psoriatic and healthy individuals were examined for clinical type, response to therapy, serum VEGFA and its receptor levels, genotypes and haplotypes.
  
  
  RESULTS
  The +405 GG, +405 CG, -1540 CA, and -1512 +Ins18 genotypes conferred a significant risk for developing psoriasis. The C-InsTC haplotype in the controls and C+InsTG, A+InsTC, and A-InsTG haplotypes in psoriatic patients were observed to be significantly high. Increased serum levels of VEGFA were detected in psoriatic patients with the C-InsTC haplotype than that in the controls. The +405 GG genotype was significantly more frequent in psoriatic patients with a positive family history, and the moderate form of psoriasis was more frequent among C+InsTG haplotype carriers than that among the other patients. The +405 GG genotype was found to be more frequent in patients responding to oral retinoids. Serum VEGFR1/FLT1 and VEGFR2/KDR levels were not significantly different when psoriatic patients and controls were stratified based on the risk polymorphic variants.
  
  
  CONCLUSIONS
  VEGFA gene +405 GG and CG, -1512+Ins18, and -1540 CA genotypes are associated with an increased risk of psoriasis in Turkish population. The G allele at +405 and an 18-bp insertion at -1512 are primarily the risk factors for psoriasis, and this risk is potentiated by the presence of the A allele at the -1540 locus.
authors: Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: Tuba
authors: T
authors: Bozduman
authors: Department of Dermatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: Sibel
authors: S
authors: Ersoy Evans
authors: Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: Sevilay
authors: S
authors: Karahan
authors: Department of Dermatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: Yildiz
authors: Y
authors: Hayran
authors: Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.; Clinical Pathology Laboratory, Hacettepe University Hospitals, Ankara, Turkey.
authors: Filiz
authors: F
authors: Akbiyik
authors: Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.; Clinical Pathology Laboratory, Hacettepe University Hospitals, Ankara, Turkey.
authors: Incilay
authors: I
authors: Lay
keywords: Angiogenesis; Psoriasis; Turkish population; VEGFA gene polymorphisms; Vascular endothelial growth factor