title: Space: A Final Frontier for Vacuolar Pathogens.
abstract: There is a fundamental gap in our understanding of how a eukaryotic cell apportions the limited space within its cell membrane. Upon infection, a cell competes with intracellular pathogens for control of this same precious resource. The struggle between pathogen and host provides us with an opportunity to uncover the mechanisms regulating subcellular space by understanding how pathogens modulate vesicular traffic and membrane fusion events to create a specialized compartment for replication. By comparing several important intracellular pathogens, we review the molecular mechanisms and trafficking pathways that drive two space allocation strategies, the formation of tight and spacious pathogen-containing vacuoles. Additionally, we discuss the potential advantages of each pathogenic lifestyle, the broader implications these lifestyles might have for cellular biology and outline exciting opportunities for future investigation.
authors: Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX, USA.
authors: Elizabeth Di Russo
authors: ED
authors: Case
authors: Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
authors: Judith A
authors: JA
authors: Smith
authors: Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA.
authors: Thomas A
authors: TA
authors: Ficht
authors: Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX, USA.
authors: James E
authors: JE
authors: Samuel
authors: Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX, USA.|Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA.|Norman Borlaug Center, Texas A&M University, College Station, TX, USA.
authors: Paul
authors: P
authors: de Figueiredo
mesh_terms: D054884:Host-Pathogen Interactions; D008561:Membrane Fusion; D014617:Vacuoles / Q000382:microbiology*
keywords: Brucella; Chlamydia; Coxiella; Legionella; Mycobacterium; intracellular pathogens; membrane fusion; vesicular trafficking