title: Insulin-Like Growth Factor-I is a Marker for the Nutritional State.
abstract: Measurement of the serum concentration of insulin-like growth factor-I (IGF-l) is generally used as a screening investigation for disorders of the growth hormone (GH)/IGF-I axis in children and adolescents with short stature. IGF-I concentration is sensitive to short-term and chronic alterations in the nutritional state, and the interpretation of IGF-I measurements requires knowledge of the child's nutritional status. In this review, we summarize the effects of nutrition on the GH/IGF-I axis, and review the clinical implications of these interactions throughout childhood, both in under-nutrition and over-nutrition.
authors: Colin P
authors: CP
authors: Hawkes
authors: Adda
authors: A
authors: Grimberg
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004044:Dietary Proteins; D002149:Energy Intake; D005260:Female; D047109:Fetal Development; D019382:Human Growth Hormone / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008286:Malabsorption Syndromes; D044342:Malnutrition / Q000097:blood; D009752:Nutritional Status / Q000502:physiology*; D009765:Obesity / Q000097:blood; D044343:Overnutrition / Q000097:blood; D011247:Pregnancy; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D004044:Dietary Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I