title: Novel Structures and Temporal Changes of Arginine Catabolic Mobile Elements in Methicillin-Resistant Staphylococcus aureus Genotypes ST5-MRSA-II and ST764-MRSA-II in Japan.
abstract: Twenty-two of 1,103 methicillin-resistant Staphylococcus aureus (MRSA) isolates containing the type II staphylococcal cassette chromosome mec element (SCCmec) (collected in Hokkaido, Japan, from 2008 to 2011) harbored the arginine catabolic mobile element (ACME). Five genetic variations were identified in the ACME-staphylococcal cassette chromosome mec composite islands, 66 to 79 kb in size. The percentage of ACME carriage temporally increased from 0.85% to 4.5% in parallel with the emergence of shorter variants (66 to 72 kb). Shorter variants may have a selective advantage and accelerate the dissemination of ACME in Japanese MRSA.
authors: Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan noriko-u@sapmed.ac.jp.
authors: Noriko
authors: N
authors: Urushibara
authors: Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors: Mitsuyo
authors: M
authors: Kawaguchiya
authors: Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors: Mayumi
authors: M
authors: Onishi
authors: Department of Admissions, Center for Medical Education, Sapporo Medical University, Sapporo, Japan.
authors: Keiji
authors: K
authors: Mise
authors: Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors: Meiji Soe
authors: MS
authors: Aung
authors: Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors: Nobumichi
authors: N
authors: Kobayashi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002876:Chromosomes, Bacterial / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D005838:Genotype; D007564:Japan; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial