title: Acute Myeloid Leukemia: analysis of epidemiological profile and survival rate.
abstract: OBJECTIVE
  To describe the epidemiological profile and the survival rate of patients with acute myeloid leukemia (AML) in a state reference pediatric hospital.
  
  
  METHODS
  Clinical-epidemiological, observational, retrospective, descriptive study. The study included new cases of patients with AML, diagnosed between 2004 and 2012, younger than 15 years.
  
  
  RESULTS
  Of the 51 patients studied, 84% were white; 45% were females and 55%, males. Regarding age, 8% were younger than 1 year, 47% were aged between 1 and 10 years, and 45% were older than 10 years. The main signs/symptoms were fever (41.1%), asthenia/lack of appetite (35.2%), and hemorrhagic manifestations (27.4%). The most affected extra-medullary site was the central nervous system (14%). In 47% of patients, the white blood cell (WBC) count was below 10,000/mm(3) at diagnosis. The minimal residual disease (MRD) was less than 0.1%, on the 15th day of treatment in 16% of the sample. Medullary relapse occurred in 14% of cases. When comparing the bone marrow MRD with the vital status, it was observed that 71.42% of the patients with type M3 AML were alive, as were 54.05% of those with non-M3 AML. The death rate was 43% and the main proximate cause was septic shock (63.6%).
  
  
  CONCLUSIONS
  In this study, the majority of patients were male, white, and older than 1 year. Most patients with WBC count <10,000/mm(3) at diagnosis lived. Overall survival was higher in patients with MRD <0.1%. The prognosis was better in patients with AML-M3.
authors: Service of Pediatric Oncology, Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil. Electronic address: marianac_lima@yahoo.com.br.
authors: Mariana Cardoso
authors: MC
authors: de Lima
authors: Service of Pediatric Oncology, Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil.
authors: Denise Bousfield
authors: DB
authors: da Silva
authors: Service of Pediatric Oncology, Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil.
authors: Ana Paula Ferreira
authors: AP
authors: Freund
authors: Service of Pediatric Oncology, Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil.
authors: Juliana Shmitz
authors: JS
authors: Dacoregio
authors: Service of Pediatric Oncology, Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil.
authors: Tatiana El Jaick Bonifácio
authors: Tel J
authors: Costa
authors: Service of Pediatric Oncology, Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil.
authors: Imaruí
authors: I
authors: Costa
authors: Service of Pediatric Oncology, Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil.
authors: Daniel
authors: D
authors: Faraco
authors: Service of Pediatric Oncology, Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil.
authors: Maurício Laerte
authors: ML
authors: Silva
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000401:mortality*; D008297:Male; D018365:Neoplasm, Residual; D011379:Prognosis; D012189:Retrospective Studies; D012772:Shock, Septic; D015996:Survival Rate
keywords: Acute myeloid leukemia; Children; Criança; Leucemia; Leucemia mielóide aguda; Leukemia