title: Dimensional assessment of behavioral changes in the cuprizone short-term exposure model for psychosis.
abstract: Recent clinical studies have suggested a role for immune/inflammatory responses in the pathophysiology of psychosis. However, a mechanistic understanding of this process and its application for drug discovery is underdeveloped. Here we assessed our recently developed cuprizone short-term exposure (CSE) mouse model across behavioral domains targeting neurocognitive and neuroaffective systems. We propose that the CSE model may be useful for understanding the mechanism associating inflammation and psychosis, with applications for drug discovery in that context.
authors: Department of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors: Mari A
authors: MA
authors: Kondo
authors: Department of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors: Daisuke
authors: D
authors: Fukudome
authors: Neurogenetics and Behavior Center, Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors: Dani R
authors: DR
authors: Smith
authors: Neurogenetics and Behavior Center, Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors: Michela
authors: M
authors: Gallagher
authors: Department of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors: Atsushi
authors: A
authors: Kamiya
authors: Department of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors: Akira
authors: A
authors: Sawa
mesh_terms: D000339:Affect; D000818:Animals; D001522:Behavior, Animal; D003071:Cognition; D003471:Cuprizone; D004195:Disease Models, Animal; D056344:Executive Function; D008297:Male; D008810:Mice, Inbred C57BL; D011618:Psychotic Disorders / Q000209:etiology / Q000523:psychology*; D012919:Social Behavior
chemical_list: D003471:Cuprizone
keywords: Behavior; Cuprizone; Cuprizone short-term exposure (CSE); Dimensional approach; Hippocampus; Inflammation; Psychosis; Research Domain Criteria (RDoC)