title: Gelsolin rs1078305 and rs10818524 polymorphisms were associated with risk of oral squamous cell carcinoma in a Chinese Han population.
abstract: BACKGROUND
  Gelsolin (GSN) is one of the most abundant actin-binding proteins, and is involved in cancer development and progression.
  
  
  METHODS
  A hospital-based case-control study including 201 patients with OSCC and 199 healthy controls was conducted. Seventeen single-nucleotide polymorphisms (SNPs) of GSN were investigated by Sequenom Mass ARRAY and iPLEX-MALDI-TOF technology.
  
  
  RESULTS
  Through comparison of the 17 SNPs on GSN gene between the two groups, SNP rs1078305 and rs10818524 were verified to be significantly associated with an increased risk of OSCC. For GSN rs1078305, the TT genotype was associated with increased risk for OSCC (OR = 1.92, 95% CI = 1.11-3.32, p = 0.028). CT/TT variants were also associated with increased risk for OSCC compared to the CC genotype (OR = 1.83, 95% CI = 1.25-3.84, p = 0.032).
  
  
  CONCLUSIONS
  The rs1078305 and rs10818524 SNPs of GSN were associated with increased risk for OSCC development in a Chinese Han population.
authors: a Department of Oral and Maxillofacial Surgery , Nanjing Stomatological Hospital, Medical School of Nanjing University , Nanjing , PR China.
authors: Xu-Dong
authors: XD
authors: Yang
authors: a Department of Oral and Maxillofacial Surgery , Nanjing Stomatological Hospital, Medical School of Nanjing University , Nanjing , PR China.
authors: Su-Feng
authors: SF
authors: Zhao
authors: a Department of Oral and Maxillofacial Surgery , Nanjing Stomatological Hospital, Medical School of Nanjing University , Nanjing , PR China.
authors: Qian
authors: Q
authors: Zhang
authors: a Department of Oral and Maxillofacial Surgery , Nanjing Stomatological Hospital, Medical School of Nanjing University , Nanjing , PR China.
authors: Wei
authors: W
authors: Li
authors: a Department of Oral and Maxillofacial Surgery , Nanjing Stomatological Hospital, Medical School of Nanjing University , Nanjing , PR China.
authors: Yu-Xin
authors: YX
authors: Wang
authors: a Department of Oral and Maxillofacial Surgery , Nanjing Stomatological Hospital, Medical School of Nanjing University , Nanjing , PR China.
authors: Xiao-Wei
authors: XW
authors: Hong
authors: a Department of Oral and Maxillofacial Surgery , Nanjing Stomatological Hospital, Medical School of Nanjing University , Nanjing , PR China.
authors: Qin-Gang
authors: QG
authors: Hu
mesh_terms: D000328:Adult; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002681:China; D005260:Female; D018260:Gelsolin / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D018260:Gelsolin
keywords: GSN; oral squamous cell carcinoma; single-nucleotide polymorphism; susceptibility