title: Melatonin Suppresses the Growth of Ovarian Cancer Cell Lines (OVCAR-429 and PA-1) and Potentiates the Effect of G1 Arrest by Targeting CDKs.
abstract: Melatonin is found in animals as well as plants. In animals, it is a hormone that anticipates the daily onset of darkness and regulates physiological functions, such as sleep timing, blood pressure, and reproduction. Melatonin has also been found to have anti-tumor properties. Malignant cancers are the most common cause of death, and the mortality rate of ovarian tumor is the highest among gynecological diseases. This study investigated the anti-tumor effects of melatonin on the ovarian cancer lines, OVCAR-429 and PA-1. We observed the accumulation of melatonin-treated cells in the G₁ phase due to the down-regulation of CDK 2 and 4. Our results suggest that in addition to the known effects on prevention, melatonin may also provide anti-tumor activity in established ovarian cancer.
authors: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 807 Kaohsiung, Taiwan. chenmed.tw@yahoo.com.tw.|Department of Gynecology and Obstetrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 807 Kaohsiung, Taiwan. chenmed.tw@yahoo.com.tw.
authors: Ching-Ju
authors: CJ
authors: Shen
authors: Department of Obstetrics & Gynecology, E-Da Hospital, E-Da Hospital/I-Shou University, 82445 Kaohsiung, Taiwan. p2696373@yahoo.com.tw.
authors: Chi-Chang
authors: CC
authors: Chang
authors: Graduate Institute of Medical Science, College of Health Sciences, Chang Jung Christian University, 71101 Tainan, Taiwan. amy073640171@yahoo.com.tw.|Innovative Research Center of Medicine, College of Health Sciences, Chang Jung Christian University, 71101 Tainan, Taiwan. amy073640171@yahoo.com.tw.
authors: Yi-Tz
authors: YT
authors: Chen
authors: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 807 Kaohsiung, Taiwan. chshla@kmu.edu.tw.|Division of Plastic Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 807 Kaohsiung, Taiwan. chshla@kmu.edu.tw.
authors: Chung-Sheng
authors: CS
authors: Lai
authors: Graduate Institute of Medical Science, College of Health Sciences, Chang Jung Christian University, 71101 Tainan, Taiwan. jenway@mail.cjcu.edu.tw.|Innovative Research Center of Medicine, College of Health Sciences, Chang Jung Christian University, 71101 Tainan, Taiwan. jenway@mail.cjcu.edu.tw.
authors: Yi-Chiang
authors: YC
authors: Hsu
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D051357:Cyclin-Dependent Kinase 2 / Q000235:genetics / Q000378:metabolism*; D051358:Cyclin-Dependent Kinase 4 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D059585:G1 Phase Cell Cycle Checkpoints; D006801:Humans; D008550:Melatonin / Q000494:pharmacology*; D010051:Ovarian Neoplasms / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; C495894:CDK2 protein, human; C495900:CDK4 protein, human; D051357:Cyclin-Dependent Kinase 2; D051358:Cyclin-Dependent Kinase 4; D008550:Melatonin
keywords: CDK; cell cycle; melatonin; ovarian cancer