title: Multiwalled Carbon Nanotubes-Dispersive Solid-Phase Extraction Coupled with UPLC-ESI-MS-MS for Simultaneous Determination of 10 Illegal Adulterants in Antihypertensive Functional Foods.
abstract: A reliable method for simultaneous determination of 10 illegal adulterants including chlortalidone, hydrochlorothiazide, indapamide, metoprolol, nifedipine, nimodipine, nitrendipine, reserpine, triamterene and valsartan in antihypertensive functional foods by ultra-high-performance liquid chromatography coupled with electrospray ionization-tandem mass spectrometry is presented in this article. The target chemicals were extracted with acetonitrile ultrasonically and cleaned up using multiwalled carbon nanotubes-dispersive solid-phase extraction. The separation was performed on a Waters ACQUITY UPLC BEH C18 Column (2.1 × 100 mm, 1.7 µm) with acetonitrile, 0.1% formic acid and 10 mmol/L ammonium acetate solution as mobile phase at a flow rate of 0.2 mL/min. Multiple reaction monitoring was applied for detection and sildenafil was used as the internal standard. The correlation coefficients of the method were >0.995, with the limits of detection of 0.022-0.30 ng/mL and the limits of quantification of 0.075-0.99 ng/mL. The interday and intraday relative standard deviations were <9.77% and the recoveries were in the range of 85.8-109%. The established method has been applied for the analysis of real samples, and reserpine was detected in a tonic wine sample with a content of 60.1 ± 3.2 mg/L.
authors: West China School of Public Health, Sichuan University, No. 17, Section 3, South Renmin Road, Chengdu 610041, China.
authors: Jielan
authors: J
authors: Hu
authors: West China School of Public Health, Sichuan University, No. 17, Section 3, South Renmin Road, Chengdu 610041, China.
authors: Li
authors: L
authors: Zeng
authors: Sichuan Center for Disease Control and Prevention, No. 6, Zhongxue Road, Chengdu 610041, China.
authors: Ling
authors: L
authors: He
authors: Sichuan Center for Disease Control and Prevention, No. 6, Zhongxue Road, Chengdu 610041, China.
authors: Fan
authors: F
authors: You
authors: West China School of Public Health, Sichuan University, No. 17, Section 3, South Renmin Road, Chengdu 610041, China Provincial Key Lab for Food Safety Monitoring and Risk Assessment of Sichuan, No.17, Section 3, South Renmin Road, Chengdu 610041, China sunchj@scu.edu.cn.
authors: Chengjun
authors: C
authors: Sun
mesh_terms: D005506:Food Contamination / Q000032:analysis*; D055951:Functional Food / Q000032:analysis*; D006973:Hypertension / Q000178:diet therapy*; D037742:Nanotubes, Carbon; D015203:Reproducibility of Results; D052616:Solid Phase Extraction / Q000379:methods*
chemical_list: D037742:Nanotubes, Carbon