title: Triazine-Based Sequence-Defined Polymers with Side-Chain Diversity and Backbone-Backbone Interaction Motifs.
abstract: Sequence control in polymers, well-known in nature, encodes structure and functionality. Here we introduce a new architecture, based on the nucleophilic aromatic substitution chemistry of cyanuric chloride, that creates a new class of sequence-defined polymers dubbed TZPs. Proof of concept is demonstrated with two synthesized hexamers, having neutral and ionizable side chains. Molecular dynamics simulations show backbone-backbone interactions, including H-bonding motifs and pi-pi interactions. This architecture is arguably biomimetic while differing from sequence-defined polymers having peptide bonds. The synthetic methodology supports the structural diversity of side chains known in peptides, as well as backbone-backbone hydrogen-bonding motifs, and will thus enable new macromolecules and materials with useful functions.
authors: Pacific Northwest National Laboratory, P.O. Box 999, Richland, WA, 99352, USA. jwgrate@pnnl.gov.
authors: Jay W
authors: http://orcid.org/0000-0002-2163-8383
authors: JW
authors: Grate
authors: Pacific Northwest National Laboratory, P.O. Box 999, Richland, WA, 99352, USA.
authors: Kai-For
authors: KF
authors: Mo
authors: Pacific Northwest National Laboratory, P.O. Box 999, Richland, WA, 99352, USA.
authors: Michael D
authors: MD
authors: Daily
mesh_terms: D006860:Hydrogen Bonding; D056004:Molecular Dynamics Simulation; D011108:Polymers / Q000737:chemistry*; D053719:Tandem Mass Spectrometry; D014227:Triazines / Q000737:chemistry*
chemical_list: D011108:Polymers; D014227:Triazines
keywords: biomimetics; macromolecules; sequence-defined polymers; simulations; solid-phase synthesis