title: Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei.
abstract: New diazabicyclo[2.2.2]octane derivatives, peniciherquamides A-C (1-3), and a novel herqueinone derivative, neoherqueinone (5), were isolated from a fungal culture broth of Penicillium herquei. The structures of these novel compounds were determined by interpretation of spectroscopic data (1D/2D NMR, MS, and IR). Four known compounds, preparaherquamide (4), peniciherqueinone (6), and herqueinone/isoherqueinone (7/7a), were also obtained. The isolated compounds were tested for anti-hepatitis C virus (HCV) activity, and peniciherquamide C (3) was found to display an IC50 value of 5.1 μM. To our knowledge, this is the first report of a diazabicyclo[2.2.2]octane derivative with anti-HCV activity.
authors: Shu
authors: S
authors: Nishikori
authors: Kenji
authors: K
authors: Takemoto
authors: Shinji
authors: S
authors: Kamisuki
authors: Department of Virology II, National Institute of Infectious Diseases , Shinjuku-ku, Tokyo 162-8640, Japan.
authors: Syo
authors: S
authors: Nakajima
authors: Graduate School of Life and Environmental Sciences, Kyoto Prefectural University , Sakyo-ku, Kyoto 606-8522, Japan.
authors: Kouji
authors: K
authors: Kuramochi
authors: Department of Virology II, National Institute of Infectious Diseases , Shinjuku-ku, Tokyo 162-8640, Japan.
authors: Senko
authors: S
authors: Tsukuda
authors: Department of Virology II, National Institute of Infectious Diseases , Shinjuku-ku, Tokyo 162-8640, Japan.
authors: Masashi
authors: M
authors: Iwamoto
authors: Yuri
authors: Y
authors: Katayama
authors: Takahiro
authors: T
authors: Suzuki
authors: Susumu
authors: S
authors: Kobayashi
authors: Department of Virology II, National Institute of Infectious Diseases , Shinjuku-ku, Tokyo 162-8640, Japan.
authors: Koichi
authors: K
authors: Watashi
authors: Fumio
authors: F
authors: Sugawara
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001372:Aza Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects*; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D001372:Aza Compounds; D001688:Biological Products; D034242:Cyclooctanes; C578397:diazabicyclo(2.2.2)octane; C000608928:peniciherquamide A