title: Individualized radiotherapy by combining high-end irradiation and magnetic resonance imaging.
abstract: Image-guided radiotherapy (IGRT) has been integrated into daily clinical routine and can today be considered the standard especially with high-dose radiotherapy. Currently imaging is based on MV- or kV-CT, which has clear limitations especially in soft-tissue contrast. Thus, combination of magnetic resonance (MR) imaging and high-end radiotherapy opens a new horizon. The intricate technical properties of MR imagers pose a challenge to technology when combined with radiation technology. Several solutions that are almost ready for routine clinical application have been developed. The clinical questions include dose-escalation strategies, monitoring of changes during treatment as well as imaging without additional radiation exposure during treatment.
authors: Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Germany. Stephanie.combs@tum.de.|Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany. Stephanie.combs@tum.de.
authors: Stephanie E
authors: SE
authors: Combs
authors: Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Germany.
authors: Fridtjof
authors: F
authors: Nüsslin
authors: Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Germany.|Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
authors: Jan J
authors: JJ
authors: Wilkens
mesh_terms: D019583:Dose Fractionation, Radiation; D004867:Equipment Design; D019983:Guideline Adherence; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D058958:Organs at Risk; D057285:Precision Medicine / Q000379:methods*; D000069079:Radiation Exposure / Q000517:prevention & control; D011832:Radiation Injuries / Q000517:prevention & control; D011879:Radiotherapy Dosage; D061089:Radiotherapy, Image-Guided / Q000295:instrumentation* / Q000379:methods*
keywords: Image-guided radiotherapy; Individualized medicine; Magnetic resonance-guided radiotherapy; Organ sparing treatments; Organs at risk