title: Health outcomes of neonates with osteogenesis imperfecta: a cross-sectional study.
abstract: OBJECTIVE
  To assess at-birth health outcomes of neonates with osteogenesis imperfecta (OI).
  
  
  METHODS
  A total of 53 women who self-reported having had at least one child with OI completed the survey. We evaluated pregnancy length, neonatal intensive care unit (NICU) usage, at-birth complications, and the child's clinical information including OI type, height and weight.
  
  
  RESULTS
  Information was gathered on a total of 77 children (60 type I, 4 type III and 13 type IV). Health conditions reported at birth included breech presentation (24%), prematurity (27%), fracture (18%), bone deformity (18%) and respiratory problems (22%). Approximately 31% (n = 24) received NICU care. There was a significant association between younger maternal age, preterm delivery and NICU admission.
  
  
  CONCLUSIONS
  Our findings suggest that newborns with OI appear to be at high risk of skeletal disorders, preterm delivery and breech presentation. Younger maternal age and preterm delivery seem to be strong predictors of the need for NICU care. Our data suggest that pregnant women with OI younger than 20 years of age may benefit from added clinical supervision in anticipation of adverse effects on their child.
authors: a Bone and Osteogenesis Imperfecta Department, Kennedy Krieger Institute, Johns Hopkins School of Medicine , Baltimore , MD , USA and.
authors: Doris P
authors: DP
authors: Yimgang
authors: a Bone and Osteogenesis Imperfecta Department, Kennedy Krieger Institute, Johns Hopkins School of Medicine , Baltimore , MD , USA and.|b Post Graduate Program in Child and Adolescent Health, Faculty of Medicine, Federal University of Rio Grande Do Sul , Porto Alegre , Brazil.
authors: Evelise
authors: E
authors: Brizola
authors: a Bone and Osteogenesis Imperfecta Department, Kennedy Krieger Institute, Johns Hopkins School of Medicine , Baltimore , MD , USA and.
authors: Jay R
authors: JR
authors: Shapiro
mesh_terms: D000328:Adult; D000367:Age Factors; D001724:Birth Weight; D001946:Breech Presentation / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D008297:Male; D009139:Musculoskeletal Abnormalities / Q000209:etiology*; D010013:Osteogenesis Imperfecta / Q000145:classification / Q000150:complications*; D011247:Pregnancy; D047928:Premature Birth / Q000209:etiology*; D011295:Prenatal Care / Q000379:methods; D011296:Prenatal Diagnosis; D012042:Registries; D012120:Respiration Disorders / Q000209:etiology; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Fracture; intensive care; neonatal outcomes; osteogenesis imperfecta; preterm delivery