title: Oct-4 is associated with gastric cancer progression and prognosis.
abstract: OBJECTIVE
  To investigate the clinical significance of Oct-4 in the development and progression of gastric cancer.
  
  
  METHODS
  Immunohistochemistry was used to analyze Oct-4 expression in 412 gastric cancer cases. Oct-4 protein levels were upregulated in gastric cancer tissues compared with adjacent noncancerous tissues.
  
  
  RESULTS
  Positive expression of Oct-4 correlated with age, depth of invasion, Lauren classification, lymph node metastasis, distant metastasis, and TNM stage. In stages I, II, and III, the 5-year survival rate of patients with high expression of Oct-4 was significantly lower than that in patients with low expression of Oct-4. In stage IV, Oct-4 expression did not correlate with the 5-year survival rate. Furthermore, multivariate analysis suggested that the depth of invasion, lymph node metastasis, distant metastasis, TNM stage, and upregulation of Oct-4 were independent prognostic factors of gastric cancer.
  
  
  CONCLUSIONS
  Oct-4 protein is a useful marker in predicting tumor progression and prognosis.
authors: Department of Surgery, Juxian People's Hospital, Rizhao People's Hospital of Traditional Chinese Medicine, Rizhao, People's Republic of China.
authors: Wen-Li
authors: WL
authors: Jiang
authors: Department of Surgery, Rizhao People's Hospital of Traditional Chinese Medicine, Rizhao, People's Republic of China.
authors: Peng-Fei
authors: PF
authors: Zhang
authors: Department of Surgery, Juxian People's Hospital, Rizhao People's Hospital of Traditional Chinese Medicine, Rizhao, People's Republic of China.
authors: Guo-Feng
authors: GF
authors: Li
authors: Department of Surgery, Juxian People's Hospital, Rizhao People's Hospital of Traditional Chinese Medicine, Rizhao, People's Republic of China.
authors: Jian-Hua
authors: JH
authors: Dong
authors: Department of Surgery, Juxian People's Hospital, Rizhao People's Hospital of Traditional Chinese Medicine, Rizhao, People's Republic of China.
authors: Xue-Song
authors: XS
authors: Wang
authors: Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou, People's Republic of China.
authors: Yuan-Yu
authors: YY
authors: Wang
keywords: gastric carcinoma; invasion; metastasis; survival rate