title: Plasma Glucose Levels Affect Cerebral 18F-FDG Distribution in Cognitively Normal Subjects With Diabetes.
abstract: OBJECTIVE
  Increased plasma glucose levels can relatively reduce F-FDG uptake in Alzheimer disease (AD)-related regions and alter the cerebral distribution pattern of F-FDG, resulting in the appearance of an AD-like pattern. However, the relationship between the reversibility of the AD-like pattern and plasma glucose levels is uncertain.
  
  
  METHODS
  Four cognitively normal elderly subjects with diabetes underwent longitudinal F-FDG PET more than 5 times at various levels of plasma glucose. F-FDG data were proportionally scaled with a global normalization method and used in volume of interest-based and voxelwise analyses. Volumes of interest were placed on representative AD-related regions: precuneus/posterior cingulate (PP), lateral parietal cortex, and frontal cortex.
  
  
  RESULTS
  Volume of interest-based analyses showed negative correlations of plasma glucose levels with F-FDG uptake in the PP (r = -0.79, P < 0.001), lateral parietal cortex (r = -0.62, P = 0.002), and frontal cortex (r = -0.73, P < 0.001), controlling for the effects of interindividual differences and age. Voxelwise analyses also showed negative correlations between the 2 factors in the PP and medial frontal areas (P < 0.05, familywise error rate corrected).
  
  
  CONCLUSIONS
  This study indicates that the distribution pattern of F-FDG changes depending on plasma glucose levels in an individual and that the AD-like pattern can appear or disappear with increasing or decreasing plasma glucose levels, respectively.
authors: From the *Research Team for Neuroimaging, and †Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors: Kenji
authors: K
authors: Ishibashi
authors: Airin
authors: A
authors: Onishi
authors: Yoshinori
authors: Y
authors: Fujiwara
authors: Kiichi
authors: K
authors: Ishiwata
authors: Kenji
authors: K
authors: Ishii
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000502:physiology / Q000503:physiopathology; D003071:Cognition; D003920:Diabetes Mellitus / Q000097:blood* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18