title: 68Ga Prostate-Specific Membrane Antigen Uptake in Renal Cell Cancer Lymph Node Metastases.
abstract: Ga prostate-specific membrane antigen (PSMA)-HBED-CC PET/CT in a patient with a history of both prostate cancer (PC) and renal cell cancer (RCC) shows high PSMA expression in the residual right seminal vesicle suggestive of local recurrence of PC as well as suspected PSMA-positive mediastinal, retroperitoneal, and iliac lymph nodes. Regarding the latter, biopsy revealed lymph node metastases from RCC excluding PC metastases. This case exemplarily demonstrates that high PSMA expression in RCC metastases can potentially mimic PC metastases. Thus, for accurate interpretation of imaging results in PC patients with additional primary tumors, knowledge of PSMA expression of non-PC tissue is necessary.
authors: From the Departments of *Nuclear Medicine and †Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Ingo
authors: I
authors: Einspieler
authors: Robert
authors: R
authors: Tauber
authors: Tobias
authors: T
authors: Maurer
authors: Markus
authors: M
authors: Schwaiger
authors: Matthias
authors: M
authors: Eiber
mesh_terms: D000085:Acetates; D000368:Aged; D000954:Antigens, Surface / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D005029:Ethylenediamines; D005710:Gallium Radioisotopes; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals
chemical_list: D000085:Acetates; D000954:Antigens, Surface; D005029:Ethylenediamines; D005710:Gallium Radioisotopes; C524457:N,N'-di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid; D019275:Radiopharmaceuticals; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II