title: Time to Relax: Mechanical Stress Release Guides Stem Cell Responses.
abstract: Stem cells integrate spatiotemporal cues, including the mechanical properties of their microenvironment, into their fate decisions. Chaudhuri et al. (2015) show that the ability of the extracellular matrix to dissipate cell-induced forces, referred to as stress-relaxation, is a key mechanical signal influencing stem cell fate and function.
authors: Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
authors: Sven D
authors: SD
authors: Sommerfeld
authors: Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA. Electronic address: jhe@jhu.edu.
authors: Jennifer H
authors: JH
authors: Elisseeff
mesh_terms: D006801:Humans; D059630:Mesenchymal Stem Cells / Q000502:physiology*