title: Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior.
abstract: The ventral hippocampus (vHPC), medial prefrontal cortex (mPFC), and basolateral amygdala (BLA) are each required for the expression of anxiety-like behavior. Yet the role of each individual element of the circuit is unclear. The projection from the vHPC to the mPFC has been implicated in anxiety-related neural synchrony and spatial representations of aversion. The role of this projection was examined using multi-site neural recordings combined with optogenetic terminal inhibition. Inhibition of vHPC input to the mPFC disrupted anxiety and mPFC representations of aversion, and reduced theta synchrony in a pathway-, frequency- and task-specific manner. Moreover, bilateral, but not unilateral, inhibition altered physiological correlates of anxiety in the BLA, mimicking a safety-like state. These results reveal a specific role for the vHPC-mPFC projection in anxiety-related behavior and the spatial representation of aversive information within the mPFC.
authors: Department of Neuroscience, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA; Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA.
authors: Nancy
authors: N
authors: Padilla-Coreano
authors: Department of Neuroscience, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA; Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA.
authors: Scott S
authors: SS
authors: Bolkan
authors: Department of Neuroscience, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA.
authors: Georgia M
authors: GM
authors: Pierce
authors: Department of Neuroscience, Barnard College, 3009 Broadway, New York, NY 10027, USA.
authors: Dakota R
authors: DR
authors: Blackman
authors: Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA.
authors: William D
authors: WD
authors: Hardin
authors: Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA.
authors: Alvaro L
authors: AL
authors: Garcia-Garcia
authors: Department of Physiology and Cellular Biophysics, Columbia University, 622 West 168(th) Street, New York, NY 10032, USA.
authors: Timothy J
authors: TJ
authors: Spellman
authors: Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA; Division of Integrative Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032 USA. Electronic address: jg343@columbia.edu.
authors: Joshua A
authors: JA
authors: Gordon
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001007:Anxiety / Q000473:pathology* / Q000503:physiopathology*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005071:Evoked Potentials / Q000502:physiology; D005508:Food Deprivation; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D017397:Prefrontal Cortex / Q000473:pathology*; D011930:Reaction Time / Q000502:physiology; D018709:Statistics, Nonparametric; D013826:Theta Rhythm / Q000502:physiology
chemical_list: D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2