title: Advances in microfluidics in combating infectious diseases.
abstract: One of the important pursuits in science and engineering research today is to develop low-cost and user-friendly technologies to improve the health of people. Over the past decade, research efforts in microfluidics have been made to develop methods that can facilitate low-cost diagnosis of infectious diseases, especially in resource-poor settings. Here, we provide an overview of the recent advances in microfluidic devices for point-of-care (POC) diagnostics for infectious diseases and emphasis is placed on malaria, sepsis and AIDS/HIV. Other infectious diseases such as SARS, tuberculosis, and dengue are also briefly discussed. These infectious diseases are chosen as they contribute the most to disability-adjusted life-years (DALYs) lost according to the World Health Organization (WHO). The current state of research in this area is evaluated and projection toward future applications and accompanying challenges are also discussed.
authors: BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore 117575, Singapore; Department of Bioengineering, University of California Los Angeles, CA 90025, United States.
authors: Andy
authors: A
authors: Tay
authors: BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602, Singapore.
authors: Andrea
authors: A
authors: Pavesi
authors: BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602, Singapore; Polytechnic University of Milan, Milan 20133, Italy.
authors: Saeed Rismani
authors: SR
authors: Yazdi
authors: BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602, Singapore; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore 117575, Singapore.
authors: Chwee Teck
authors: CT
authors: Lim
authors: BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602, Singapore; School of Mechanical and Manufacturing Engineering, Australian Centre for NanoMedicine, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: m.warkiani@unsw.edu.au.
authors: Majid Ebrahimi
authors: ME
authors: Warkiani
mesh_terms: D000818:Animals; D003141:Communicable Diseases / Q000175:diagnosis*; D006801:Humans; D051379:Mice; D008828:Microbiological Techniques; D046210:Microfluidic Analytical Techniques
keywords: Diagnostics; HIV; Infectious diseases; Malaria; Microfluidics; Point-of-care; Sepsis