title: Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea.
abstract: BACKGROUND
  In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive proliferation of cells in the sensory region, suggesting that Wnt signaling could be used to regenerate the sensory epithelium in the damaged adult inner ear. Manipulation of Wnt signaling for regeneration will require an understanding of the dynamics of Wnt pathway gene expression in the ear. We present a comprehensive screen for 84 Wnt signaling related genes across four developmental and postnatal time points.
  
  
  RESULTS
  We identified 72 Wnt related genes expressed in the inner ear on embryonic day (E) 12.5, postnatal day (P) 0, P6 and P30. These genes included secreted Wnts, Wnt antagonists, intracellular components of canonical signaling and components of non-canonical signaling/planar cell polarity.
  
  
  CONCLUSIONS
  A large number of Wnt signaling molecules were dynamically expressed during cochlear development and in the early postnatal period, suggesting complex regulation of Wnt transduction. The data revealed several potential key regulators for further study.
authors: Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
authors: Ruishuang
authors: R
authors: Geng
authors: Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
authors: Teppei
authors: T
authors: Noda
authors: Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
authors: Joanna F
authors: JF
authors: Mulvaney
authors: Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.|Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
authors: Vincent Y W
authors: VY
authors: Lin
authors: Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, United States of America.
authors: Albert S B
authors: AS
authors: Edge
authors: Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.|Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.|Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
authors: Alain
authors: A
authors: Dabdoub
mesh_terms: D000818:Animals; D003051:Cochlea / Q000166:cytology / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism*; D003053:Cochlear Duct / Q000166:cytology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D042541:Intracellular Space / Q000378:metabolism; D051379:Mice; D062211:Spatio-Temporal Analysis; D051153:Wnt Proteins / Q000037:antagonists & inhibitors; D060449:Wnt Signaling Pathway / Q000235:genetics*
chemical_list: D051153:Wnt Proteins