title: Susceptibility pattern of uropathogens to ciprofloxacin at the Ghana police hospital.
abstract: BACKGROUND
  Reports of increasing resistance of uropathogens to antimicrobials is of global concern. Culture and drug susceptibility tests remain a vital guide to effective therapy. The aim of this study was to determine the susceptibility pattern of isolated uropathogens to ciprofloxacin at the Ghana Police Hospital.
  
  
  METHODS
  A total of 705 mid-stream urine samples were collected from patients suspected of having urinary tract infection, and visited the Ghana Police Hospital's laboratory from December 2013 to March 2014. Samples were cultured and isolates identified by standard methods, after which isolates susceptibility to ciprofloxacin was determined.
  
  
  RESULTS
  Prevalence of urinary tract infection among patients' whose samples were analyzed was 15.9%. Predominant uropathogens isolated were E. coli (46.4%), Coliform (41.1%) and Coliform spp. with Candida (6.2%). Other isolates were Pseudomonas spp. (2.7%), Salmonella spp. (1.8%), Candida spp. (0.9%) and Klebsiella spp (0.9%). The overall resistance among the top three isolated uropathogens to ciprofloxacin was 35.9%. Resistance pattern demonstrated by respective isolates to ciprofloxacin were: E. coli (38.5%), Coliform (54.3%), and Coliform spp. with Candida (15%). The other isolates showed 100% sensitivity.
  
  
  CONCLUSIONS
  This study revealed a relatively high ciprofloxacin resistance among isolated uropathogens, hence, the need for prudent prescribing and use of ciprofloxacin in urinary tract infection management.
authors: Ghana Police Hospital, Pharmacy Department, Accra, Ghana.
authors: Daniel Kwame
authors: DK
authors: Afriyie
authors: Ministry of Health, Accra, Ghana.
authors: Martha
authors: M
authors: Gyansa-Lutterodt
authors: Department of Pharmacology and Toxicology, University of Ghana School of Pharmacy, Accra, Ghana.
authors: Seth Kwabena
authors: SK
authors: Amponsah
authors: School of Biomedical and Allied Health Sciences, University of Ghana.
authors: George
authors: G
authors: Asare
authors: Ghana Police Hospital, Pharmacy Department, Accra, Ghana.
authors: Vanessa
authors: V
authors: Wiredu
authors: Ghana Police Hospital, Pharmacy Department, Accra, Ghana.
authors: Edem
authors: E
authors: Wormenor
authors: Department of Pharmacology and Toxicology, University of Ghana School of Pharmacy, Accra, Ghana.
authors: Kwasi Agyei
authors: KA
authors: Bugyei
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D002939:Ciprofloxacin / Q000494:pharmacology*; D003430:Cross-Sectional Studies; D024881:Drug Resistance, Bacterial; D005260:Female; D005869:Ghana; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin
keywords: Urinary tract infection; antibiotics; isolates; susceptibility; uropathogens