title: Systematic Literature Review and Meta-Analysis of the Association of Sarcopenia With Mortality.
abstract: BACKGROUND
  The World Health Organization (2002) indicates that the prevention of frailty is a key indicator of successful aging, and the assessment of the muscular system is the core for determining the frailty syndrome in older adults. Sarcopenia in older adults will affect more than 50 million people and will affect more than 200 million people after 40 years. Systematic literature reviews have yet to focus on the association between sarcopenia and mortality.
  
  
  OBJECTIVE
  The aims of this study were to determine the correlation between sarcopenia and mortality by using various evaluation methods and to analyze any differences among the resulting correlations of the different assessment tools.
  
  
  METHODS
  This study conducted a systematic review of relevant studies in four databases (Cochrane Library, MEDLINE, Cumulative Index to Nursing and Allied Health Literature, and Ovid). The inclusion criteria were prospective research, the results included mortality or death, and risk estimates included risk ratio or hazard ratio estimates and 95% confidence intervals. Exclusion criteria included studies that provided no sarcopenia data, the risk of mortality or death, or data indicating deaths from cancers and in hospitals.
  
  
  RESULTS
  This study identified 10 studies that have investigated the association between sarcopenia and mortality with an average follow up of 4.17 years. In total, these studies have sampled 3,797 people and recorded 1,010 deaths. The result suggested that the risk of mortality in the sarcopenia group was higher than that in the nonsarcopenia group.
  
  
  CONCLUSIONS
  Although the results of evidence-based studies have suggested that sarcopenia is a geriatric syndrome associated with increased mortality, few studies have focused on decreasing sarcopenia mortality. Therefore, nurse practitioners must be aware of the correlation between sarcopenia and the mortality rate and become actively involved in developing intervention methods for reducing the mortality risk of sarcopenia.
authors: Professor, School of Nursing, College of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
authors: Shu-Fang
authors: SF
authors: Chang
authors: Research Assistant, School of Nursing, College of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
authors: Pei-Ling
authors: PL
authors: Lin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D016330:Frail Elderly / Q000706:statistics & numerical data; D006801:Humans; D011446:Prospective Studies; D055948:Sarcopenia / Q000401:mortality*
keywords: geriatric assessment; meta-analysis; mortality; nursing; sarcopenia; systematic review