title: [Expression Difference of MicroRNAs in Colorectal Adenoma and Colorectal Cancer].
abstract: OBJECTIVE
  To investigate the expression difference of microRNAs in colorectal tubular adenoma, tubulovillous adenoma and colorectal cancer.
  
  
  METHODS
  Real time-polymerase chain reaction was used to analysis the expression level of miR-1, miR-9, miR-31, miR-135a, miR-137 and miR-145 between colorectal tubular adenoma (n=44), tubulovillous adenoma (n=16), colorectal cancer (n=20) and paired paracancerous normal colorectal tissues.
  
  
  RESULTS
  Compared with paired paracancerous normal colorectal tissues, colorectal tubular adenoma had decreased expression of miR-1, miR-9, miR-137 and miR-145 as well as increased expression of miR-31 and miR-135a. Colorectal tubulovillous adenoma had decreased levels of miR-1, miR-137, miR-145, as well as increased levels of miR-9, miR-135a, and miR-31. Colorectal cancer had the expressions of miR-1, miR-9, miR-137 and miR-145 decreased while the expression of miR-135a and miR-31 increased.
  
  
  CONCLUSIONS
  The differential expressions of microRNAs suggested that miRNAs participate in the development of colorectal adenoma and cancer.
authors: Lin-lin
authors: LL
authors: Zhu
authors: Wei
authors: W
authors: Chen
authors: Jin
authors: J
authors: Wang
authors: Tao
authors: T
authors: Gan
authors: Yi-ping
authors: YP
authors: Wang
authors: Jin-lin
authors: JL
authors: Yang
mesh_terms: D000236:Adenoma / Q000378:metabolism*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D035683:MicroRNAs