title: [Severe erythema and pustules after antibiotic use: acute generalised exanthematous pustulosis].
abstract: BACKGROUND
  Acute generalised exanthematous pustulosis (AGEP) is a rare and self-limiting pustular cutaneous reaction to a drug or infection.
  
  
  METHODS
  A 62-year-old male presented to the Emergency Department with fever, erythema and pustules on both thighs. The initial blood analysis showed increased inflammatory parameters. The patient was admitted to the Dermatology Department with suspected AGEP. All medication was stopped. The diagnosis was confirmed histologically. During hospitalisation, the cutaneous reaction spread over 30% of the skin surface. Seven days after onset, the skin disorder regressed and the patient was discharged after 16 days. Use of amoxicillin/clavulanic acid was very likely the triggering factor for the development of AGEP.
  
  
  CONCLUSIONS
  AGEP, although self-limiting, can have a fulminant course, requiring admission to a burns centre. It is imperative that rechallenge with the triggering drug is avoided.
authors: Universiteit Gent, faculteit Geneeskunde en Gezondheidswetenschappen, Gent, België.
authors: Thomas
authors: T
authors: Vandekerckhove
authors: Linda
authors: L
authors: Temmerman
authors: Paul
authors: P
authors: Calle
authors: Marieke
authors: M
authors: Dutré
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis* / Q000209:etiology*; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge; D013848:Thigh / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination