title: Lithium doped calcium phosphate cement maintains physical mechanical properties and promotes osteoblast proliferation and differentiation.
abstract: Calcium phosphate cement (CPC) has been widely used in bone tissue repairing due to its physical mechanical properties and biocompatibility. Addition of trace element to CPC has shown promising evidence to improve the physical properties and biological activities of CPC. Lithium (Li) has effect on osteoblast proliferation and differentiation. In this study, we incorporated Li to CPC and examined the physical properties of Li/CPC and its effect on osteoblast proliferation and differentiation. We found that Li doped CPC maintained similar setting time, pore size distribution, compressive strength, composition, and morphology as CPC without Li. Additionally, Li doped CPC improved osteoblast proliferation and differentiation significantly compared to CPC without Li. To our knowledge, our results, for the first time, show that Li doped CPC has beneficial effect on osteoblast in cell culture while keeps the excellent physical-mechanical properties of CPC. This study will lead to potential application of Li doped CPC in bone tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 944-952, 2017.
authors: The Fourth Affiliated Hospital of Guangxi Medical University/Liu Zhou Work's Hospital, Liuzhou, Guangxi, 545005, China.
authors: Li
authors: L
authors: Li
authors: The Fourth Affiliated Hospital of Guangxi Medical University/Liu Zhou Work's Hospital, Liuzhou, Guangxi, 545005, China.
authors: Renchong
authors: R
authors: Wang
authors: The Fourth Affiliated Hospital of Guangxi Medical University/Liu Zhou Work's Hospital, Liuzhou, Guangxi, 545005, China.
authors: Baichuan
authors: B
authors: Li
authors: The Fourth Affiliated Hospital of Guangxi Medical University/Liu Zhou Work's Hospital, Liuzhou, Guangxi, 545005, China.
authors: Wei
authors: W
authors: Liang
authors: Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
authors: Haobo
authors: H
authors: Pan
authors: Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
authors: Xu
authors: X
authors: Cui
authors: The Fourth Affiliated Hospital of Guangxi Medical University/Liu Zhou Work's Hospital, Liuzhou, Guangxi, 545005, China.
authors: Jingli
authors: J
authors: Tang
authors: The Fourth Affiliated Hospital of Guangxi Medical University/Liu Zhou Work's Hospital, Liuzhou, Guangxi, 545005, China.
authors: Bing
authors: B
authors: Li
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002454:Cell Differentiation; D049109:Cell Proliferation; D019245:Compressive Strength; D008094:Lithium / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; C020243:calcium phosphate; D008094:Lithium
keywords: calcium phosphate cement; lithium; osteoblast proliferation; physical mechanical properties