title: MxA mRNA expression as a biomarker of interferon beta response in multiple sclerosis patients.
abstract: Myxovirus resistance protein A (MxA) is a molecule induced after interferon-β injection. The aim of this study was to investigate whether MxA determination one year after starting interferon-β can predict treatment response in multiple sclerosis patients. MxA mRNA expression was evaluated in blood samples obtained at baseline and at month 12. Clinical variables were prospectively recorded. A threshold of 5 was defined to establish MxA induction. On survival analysis, time to the next relapse and to EDSS progression were significantly longer in patients showing MxA induction, suggesting that MxA induction after one year may be useful to identify interferon-β responders.
authors: Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge-IDIBELL, Edifici Tècnic-Quirúrgic, Planta 1, mòdul E, Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain. Electronic address: ematas@bellvitgehospital.cat.
authors: Elisabet
authors: E
authors: Matas
authors: Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge-IDIBELL, Edifici Tècnic-Quirúrgic, Planta 1, mòdul E, Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain. Electronic address: lbau@bellvitgehospital.cat.
authors: Laura
authors: L
authors: Bau
authors: Translational Research Laboratory, Institut Català d'Oncologia-IDIBELL, Gran via s/n, L'Hospitalet de Llobregat 08907, Spain. Electronic address: mmi@iconcologia.net.
authors: María
authors: M
authors: Martínez-Iniesta
authors: Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge-IDIBELL, Edifici Tècnic-Quirúrgic, Planta 1, mòdul E, Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain. Electronic address: luciaromero@bellvitgehospital.cat.
authors: Lucía
authors: L
authors: Romero-Pinel
authors: Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge-IDIBELL, Edifici Tècnic-Quirúrgic, Planta 1, mòdul E, Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain; Department of Neurology, Joan XXIII University Hospital, Universitat Rovira i Virgili, Dr. Mallafrè Guasch, 4, Tarragona 43005, Spain. Electronic address: amane.hj23.ics@gencat.cat.
authors: M Alba
authors: MA
authors: Mañé-Martínez
authors: Department of Neurology, Hospital del Mar Medical Research Institute, Dr. Aiguader, 88, Barcelona 08003, Spain. Electronic address: acobo@imim.es.
authors: Álvaro
authors: Á
authors: Cobo-Calvo
authors: Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge-IDIBELL, Edifici Tècnic-Quirúrgic, Planta 1, mòdul E, Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain. Electronic address: smartinezy@bellvitgehospital.cat.
authors: Sergio
authors: S
authors: Martínez-Yélamos
mesh_terms: D000328:Adult; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D016899:Interferon-beta / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D011446:Prospective Studies; D012333:RNA, Messenger / Q000378:metabolism*; D018709:Statistics, Nonparametric; D016019:Survival Analysis
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D015415:Biomarkers; D007155:Immunologic Factors; C499330:MAX protein, human; D012333:RNA, Messenger; D016899:Interferon-beta
keywords: Biomarker; Interferon-beta; Multiple sclerosis; MxA; Treatment response