title: Relationship between ultrasound elastography and myofibroblast distribution in breast cancer and its clinical significance.
abstract: The study investigated the relationship between ultrasound elastography (USE) scoring and myofibroblast distribution with expression features of α-SMA +/CD34- in patients of Uyghur and Han ethnicities with breast masses in Xinjiang, China. The data was used to evaluate its clinical significance in the early diagnosis of breast cancer. A total of 300 patients with breast masses were included in the study, which involved conventional sonography and USE, with histopathologic diagnosis as the reference standard. Myofibroblast distribution was investigated by detecting the expression levels of α-SMA and CD34 in lesions using immunohistochemistry and real-time PCR. Out of 300 lesions, 185 were histologically malignant and 115 benign. The mean elasticity score for malignant lesions was significantly higher than for benign lesions. The expression level of α-SMA was elevated while the expression level of CD34 was lower in malignancies, compared with benign lesions. The expression of α-SMA was positively associated with the USE scores, while a negative relationship was observed between CD34 expression and USE scoring. The combination of USE and molecular diagnosis provides a promising modality for the early diagnosis and evaluation of the risks in particular types of breast cancer.
authors: Department of Ultrasound, the Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang, China.
authors: Yi
authors: Y
authors: Hao
authors: Central Laboratory of XinJiang Medical University/Collaborative Innovation Center of XinJiang Medical University, Urumqi 830011, Xinjiang, China.
authors: Xia
authors: X
authors: Guo
authors: Department of breast surgery, the Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang, China.
authors: Binlin
authors: B
authors: Ma
authors: Research Service Office, the Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang, China.
authors: Lin
authors: L
authors: Zhu
authors: Department of Ultrasound, the Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang, China.
authors: Lisha
authors: L
authors: Liu
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000235:genetics / Q000378:metabolism; D019540:Area Under Curve; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002681:China; D055088:Early Detection of Cancer; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D058628:Myofibroblasts / Q000378:metabolism / Q000473:pathology*; D012372:ROC Curve; D060888:Real-Time Polymerase Chain Reaction
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D018952:Antigens, CD34