title: Nickel-Catalyzed Hydroacylation of Styrenes with Simple Aldehydes: Reaction Development and Mechanistic Insights.
abstract: The first nickel-catalyzed intermolecular hydroacylation reaction of alkenes with simple aldehydes has been developed. This reaction offers a new approach to the selective preparation of branched ketones in high yields (up to 99%) and branched selectivities (up to 99:1). Experimental data provide evidence for reversible formation of acyl-nickel-alkyl intermediate, and DFT calculations show that the aldehyde C-H bond transfer to a coordinated alkene without oxidative addition is involved. The origin of the reactivity and regioselectivity of this reaction was also investigated computationally, which are consistent with experimental observations.
authors: Li-Jun
authors: LJ
authors: Xiao
authors: Xiao-Ning
authors: XN
authors: Fu
authors: Min-Jie
authors: MJ
authors: Zhou
authors: Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, China.
authors: Jian-Hua
authors: JH
authors: Xie
authors: Li-Xin
authors: LX
authors: Wang
authors: Xiu-Fang
authors: XF
authors: Xu
authors: Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, China.
authors: Qi-Lin
authors: QL
authors: Zhou