title: Hot Topics in Primary Care: Management of Opioid-induced Constipation.
abstract: Constipation is a common complication of opioid therapy that contributes to substantial patient morbidity, decreased productivity, and opioid nonadherence. Other causes of constipation may occur concomitantly and should be investigated. Although evidence supporting their use is limited, the use of fiber, water, laxatives, and/or exercise is recommended in current guidelines as initial management. Peripherally acting μ-opioid receptor antagonists are important treatment options, are well-tolerated, and improve many signs and symptoms of OIC in patients taking an opioid for chronic noncancer pain.
authors: Professor of Medicine, Chief of Gastroenterology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
authors: David A
authors: DA
authors: Johnson
authors: Professor of Neurology, Director, Comprehensive Pain Center, Albany Medical College, Albany, New York, USA.
authors: Charles E
authors: CE
authors: Argoff
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000627:therapeutic use; D059350:Chronic Pain / Q000188:drug therapy; D003131:Combined Modality Therapy; D003248:Constipation / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D011320:Primary Health Care / Q000379:methods
chemical_list: D000701:Analgesics, Opioid