title: Medical management of chronic rhinosinusitis - an update.
abstract: Chronic rhinosinusitis (CRS) is an epidemiologically important, chronic inflammatory disease process affecting the paranasal sinuses with significant and extensively reported economic implications. Despite an elusive pathophysiologic mechanism underlying this disease process, treatment outcomes are encouraging with the employment of an array of medical and surgical therapies. The goal of this paper is to provide a comprehensive, up to date analysis of the literature concerning the medical management of CRS by highlighting the most recent evidence based recommendations addressing this ongoing field of research.
authors: a Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine , University of Pennsylvania , Philadelphia , PA , USA.
authors: Joseph S
authors: JS
authors: Schwartz
authors: a Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine , University of Pennsylvania , Philadelphia , PA , USA.
authors: Bobby A
authors: BA
authors: Tajudeen
authors: a Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine , University of Pennsylvania , Philadelphia , PA , USA.|b Philadelphia Veterans Affairs Medical Center , Philadelphia , PA , USA.|c Perelman School of Medicine , University of Pennsylvania , Philadelphia , PA , USA.|d Monell Chemical Senses Centre , Philadelphia , PA , USA.
authors: Noam A
authors: NA
authors: Cohen
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D006801:Humans; D012220:Rhinitis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents
keywords: Chronic rhinosinusitis; anti-IL 5; anti-IgE; antimicrobial therapy; aspirin desensitization; immunotherapy; intranasal corticosteroids; leukotriene antagonists; oral corticosteroids; topical irrigations