title: Clinical Characteristics of Severe Histiocytic Necrotizing Lymphadenitis (Kikuchi-Fujimoto Disease) in Children.
abstract: OBJECTIVE
  To analyze the clinical characteristics of children with Kikuchi-Fujimoto disease focusing on cases with prolonged fever.
  
  
  METHODS
  This was a retrospective study of children diagnosed with Kikuchi-Fujimoto disease from March 2003 to February 2015 in South Korea. Electronic medical records were searched for clinical and laboratory manifestations.
  
  
  RESULTS
  Among 86 histopathologically confirmed cases, the mean age was 13.2 (SD ± 3.1) years, and male to female ratio was 1:1.32. Cervical lymph node enlargement, found in 85 of the patients (99%), was predominantly unilateral in 64 (75%), and involved the cervical lymph node level V in 67 (81%). Fever was present in 76% of the cases, with a median duration of 9 days (IQR 0.25-17.0). Multivariate analysis revealed that a high fever peak ≥ 39.0°C (P = .010) and presentation with ≥ 2 systemic symptoms other than fever (P = .027) were factors that were significantly associated with longer fever duration. As the size of the largest lymph node's short diameter increased, the fever duration increased (P = .015). Leukopenia (P = .022) also had a significant association with a longer fever duration. Patients with sonographic findings of conglomerated enlarged lymph nodes had a longer median duration of fever compared with those with separate enlarged lymph nodes (11 vs 4.5 days, P = .019).
  
  
  CONCLUSIONS
  Patients with high fever, more systemic symptoms, leukopenia, and larger lymph nodes with a conglomerated distribution may benefit from early recognition and selective consideration of corticosteroid therapy.
authors: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors: Hyun Mi
authors: HM
authors: Kang
authors: Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors: Ji Young
authors: JY
authors: Kim
authors: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea.
authors: Eun Hwa
authors: EH
authors: Choi
authors: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea.
authors: Hoan Jong
authors: HJ
authors: Lee
authors: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea.
authors: Ki Wook
authors: KW
authors: Yun
authors: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address: mdopd@hanmail.net.
authors: Hyunju
authors: H
authors: Lee
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D057286:Electronic Health Records; D005260:Female; D005334:Fever / Q000150:complications; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D007970:Leukopenia / Q000150:complications; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D015999:Multivariate Analysis; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence; D056910:Republic of Korea; D012189:Retrospective Studies; D012621:Seasons; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D011241:Prednisone