title: Long non-coding RNA PVT1 and cancer.
abstract: Genome-wide sequencing technologies have led to the identification of many non-coding RNAs and revealed an important role for these molecules in cancer. Although there have been many studies on the role of short non-coding RNAs in cancer, much work remains to characterize the functions of long non-coding RNAs. PVT1, a long non-coding RNA encoded by the human PVT1 gene, is located in the well-known cancer-related region 8q24, also known as the 8q24 'gene desert.' PVT1 has three main molecular mechanisms of action: participating in DNA rearrangements, encoding microRNAs, and interacting with MYC. Studies on the association between PVT1 and cancer have shown that PVT1 is a potential oncogene in a variety of cancer types. However, the underlying molecular mechanisms of PVT1 in cancer remain unknown. Further studies of PVT1 will be required to test the utility of this molecule as a target for cancer diagnosis and therapy, and they should also increase our understanding of the role of long non-coding RNAs in tumorigenesis.
authors: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union, Medical College, Beijing 100730, China.
authors: Ming
authors: M
authors: Cui
authors: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union, Medical College, Beijing 100730, China.
authors: Lei
authors: L
authors: You
authors: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union, Medical College, Beijing 100730, China.
authors: Xiaoxia
authors: X
authors: Ren
authors: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union, Medical College, Beijing 100730, China.
authors: Wenjing
authors: W
authors: Zhao
authors: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union, Medical College, Beijing 100730, China. Electronic address: lqpumc@126.com.
authors: Quan
authors: Q
authors: Liao
authors: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union, Medical College, Beijing 100730, China. Electronic address: zhao8028@263.net.
authors: Yupei
authors: Y
authors: Zhao
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics*; D063646:Carcinogenesis / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers; C521123:PVT1 long-non-coding RNA, human; D062085:RNA, Long Noncoding
keywords: Cancer; Long non-coding RNAs; PVT1; Tumorigenesis