title: Modified penetrating keratoplasty with Acell®bioscaffold implant in seven horses with deep full-thickness corneal stromal abscess.
abstract: OBJECTIVE
  To describe and evaluate a modified penetrating keratoplasty technique utilizing ACell®for management of equine deep stromal or full-thickness corneal stromal abscesses (SA).
  
  
  METHODS
  Cases presenting to the University of Georgia Ophthalmology service for surgical management of SA necessitating penetrating keratoplasty (PK) were included in the study population. Surgery entailed the use of an ACell®disk sutured within the deep level of a stepped full-thickness corneal incision with an overlying conjunctival pedicle flap placed in the superficial step incision. Patients were evaluated for success as defined by a comfortable, visual outcome.
  
  
  RESULTS
  Surgery was performed in seven horses. Conjunctival flap incorporation and globe retention occurred in all patients. Functional vision was maintained in six of seven eyes (85.7%) at last follow-up examination (mean of 87.6 days [range 41-251 days]). Mean size of ACell®implant was six millimeters (range 4-8 mm). Postoperative complications included moderate to severe anterior uveitis (n = 2), diffuse keratitis (n = 1), incipient cataract formation (n = 3), and anterior and posterior synechiae (n = 1).
  
  
  CONCLUSIONS
  This technique is a viable option for treatment of equine SA requiring PK. The use of bioscaffold implant is an alternative to frozen and fresh donor cornea transplantation.
authors: Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors: Brian M
authors: BM
authors: Cichocki
authors: Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors: Kathern E
authors: KE
authors: Myrna
authors: Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors: Phillip A
authors: PA
authors: Moore
mesh_terms: D000038:Abscess / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D003316:Corneal Diseases / Q000601:surgery*; D003319:Corneal Stroma / Q000601:surgery*; D005260:Female; D006734:Horse Diseases / Q000601:surgery*; D006736:Horses; D015948:Keratoplasty, Penetrating / Q000295:instrumentation / Q000379:methods / Q000662:veterinary*; D008297:Male; D054457:Tissue Scaffolds / Q000662:veterinary*
keywords: acell; acellular submucosa; corneal implant; equine; extracellular matrix; stromal abscess