title: Recent discoveries and emerging therapeutics in eosinophilic esophagitis.
abstract: Eosinophilic esophagitis (EoE) is an allergy-mediated disease culminating in severe eosinophilic inflammation and dysfunction of the esophagus. This chronic disorder of the esophagus causes significant morbidity, poor quality of life, and complications involving fibrosis and esophageal remodeling. Overlapping features between EoE and gastroesophageal reflux disease (GERD) pose great challenges to differentiating the two conditions, although the two disorders are not mutually exclusive. Recent findings suggest that the confounding condition proton pump inhibitor - responsive esophageal eosinophilia (PPI-REE) is likely a subset of EoE. Since PPIs have therapeutic properties that can benefit EoE, PPIs should be considered as a therapeutic option for EoE rather than a diagnostic screen to differentiate GERD, PPI-REE, and EoE. Other current treatments include dietary therapy, corticosteroids, and dilation. Immunomodulators and biologic agents might have therapeutic value, and larger trials are needed to assess efficacy and safety. Understanding the pathophysiology of EoE is critical to the development of novel therapeutics.
authors: Aakash Goyal, Department of Pediatrics, Division of Gastroenterology, Children's Health Children's Medical Center and University of Texas Southwestern Medical Center, Dallas, TX 75390-9063, United States.
authors: Aakash
authors: A
authors: Goyal
authors: Aakash Goyal, Department of Pediatrics, Division of Gastroenterology, Children's Health Children's Medical Center and University of Texas Southwestern Medical Center, Dallas, TX 75390-9063, United States.
authors: Edaire
authors: E
authors: Cheng
keywords: Eosinophilic esophagitis; Eotaxin-3; Gastroesophageal reflux disease; Interleukin-5; Proton pump inhibitor-responsive esophageal eosinophilia; Proton pump inhibitors