title: Luteal phase support after mild ovulation induction with intrauterine insemination: an on-going debate.
abstract: OBJECTIVE
  To evaluate the effect of luteal phase support (LPS) using progesterone vaginal gel on pregnancy rate (PR) and live birth rate (LBR) during cycles in which controlled ovarian stimulation (COH) was performed using gonadotropins with intrauterine insemination (IUI) cycles in patients with unexplained infertility and polycystic ovarian syndrome.
  
  
  METHODS
  From 2010 to 2015, all IUI cycles in which COH was performed using gonadotropins were evaluated retrospectively. LPS was not used until July 2013, after which vaginal progesterone gel was applied in the luteal phase of IUI cycles. Both groups of patients were evaluated in terms of the effect of LPS on PR and LBR.
  
  
  RESULTS
  In total, 1578 IUI cycles were evaluated, of which 481 were LPS (+) and 1097 LPS (-). PR and LBR per cycle were 10.6% and 7.4%, respectively, in the LPS (+) group, and 11.6% and 7.7%, respectively, in the LPS (-) group (p = 0.31 and p = 0.25). PR and LBR per patient were 17% and 12%, respectively, in the LPS (+) group, and 17.4% and 12.3%, respectively, in the LPS (-) group (p = 0.48 and p = 0.82).
  
  
  CONCLUSIONS
  We found no difference in PR and LBR per cycle and per patient according to the use of LPS in IUI cycles in which COH was performed using gonadotropins. Thus, routine use of LPS in gonadotropin-stimulated cycles requires further research involving larger numbers of patients.
authors: a Division of Reproductive Endocrinology and IVF Unit and.
authors: Pinar Caglar
authors: PC
authors: Aytac
authors: a Division of Reproductive Endocrinology and IVF Unit and.
authors: Esra
authors: E
authors: Bulgan Kilicdag
authors: a Division of Reproductive Endocrinology and IVF Unit and.
authors: Bulent
authors: B
authors: Haydardedeoglu
authors: a Division of Reproductive Endocrinology and IVF Unit and.
authors: Erhan
authors: E
authors: Simsek
authors: a Division of Reproductive Endocrinology and IVF Unit and.
authors: Tayfun
authors: T
authors: Cok
authors: b Division of Oncology, Department of Obstetrics and Gynecology , Faculty of Medicine, Baskent University , Adana , Turkey.
authors: Gonca
authors: G
authors: Coban
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D005260:Female; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D008183:Luteal Phase / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage / Q000494:pharmacology*; D012189:Retrospective Studies; D014622:Vaginal Creams, Foams, and Jellies; D055815:Young Adult
chemical_list: D006062:Gonadotropins; D014622:Vaginal Creams, Foams, and Jellies; D011374:Progesterone
keywords: Gonadotrophins; insemination; luteal phase support; pregnancy rate; vaginal progesterone gel