title: The Application of Aptamers for Immunohistochemistry.
abstract: Immunohistochemistry has helped to make surgical pathology the "gold" standard for tumor diagnosis. However, given the numerous problems associated with the use of antibodies for the staining of cellular markers in paraffin-embedded tissues, there is a requirement for novel agents that have the advantages of antibodies, but with few of the disadvantages. Aptamers, which are chemical antibodies, are highly specific and sensitive, like their protein counterparts, but display few of the disadvantages. These molecules represent a unique reagent that has the potential to revolutionize the field of histopathological diagnostics. In this study, we present a review of some of the aptamers that have been validated for use in diagnoses and suggest some of the advantages to using these molecules in the future.
authors: 1 School of Medicine, Deakin University , Geelong, Victoria, Australia .
authors: Michelle
authors: M
authors: Bauer
authors: 1 School of Medicine, Deakin University , Geelong, Victoria, Australia .
authors: Joanna
authors: J
authors: Macdonald
authors: 1 School of Medicine, Deakin University , Geelong, Victoria, Australia .
authors: Justin
authors: J
authors: Henri
authors: 1 School of Medicine, Deakin University , Geelong, Victoria, Australia .|2 Centre for Molecular and Medical Research, Deakin University , Geelong, Victoria, Australia .
authors: Wei
authors: W
authors: Duan
authors: 1 School of Medicine, Deakin University , Geelong, Victoria, Australia .|2 Centre for Molecular and Medical Research, Deakin University , Geelong, Victoria, Australia .
authors: Sarah
authors: S
authors: Shigdar
mesh_terms: D000906:Antibodies / Q000235:genetics* / Q000627:therapeutic use; D052157:Aptamers, Nucleotide / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry / Q000639:trends; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D016612:Paraffin Embedding; D052156:SELEX Aptamer Technique / Q000639:trends*
chemical_list: D000906:Antibodies; D052157:Aptamers, Nucleotide