title: First clinical experience with a dedicated MRI-guided high-intensity focused ultrasound system for breast cancer ablation.
abstract: OBJECTIVE
  To assess the safety and feasibility of MRI-guided high-intensity focused ultrasound (MR-HIFU) ablation in breast cancer patients using a dedicated breast platform.
  
  
  METHODS
  Patients with early-stage invasive breast cancer underwent partial tumour ablation prior to surgical resection. MR-HIFU ablation was performed using proton resonance frequency shift MR thermometry and an MR-HIFU system specifically designed for breast tumour ablation. The presence and extent of tumour necrosis was assessed by histopathological analysis of the surgical specimen. Pearson correlation coefficients were calculated to assess the relationship between sonication parameters, temperature increase and size of tumour necrosis at histopathology.
  
  
  RESULTS
  Ten female patients underwent MR-HIFU treatment. No skin redness or burns were observed in any of the patients. No correlation was found between the applied energy and the temperature increase. In six patients, tumour necrosis was observed with a maximum diameter of 3-11 mm. In these patients, the number of targeted locations was equal to the number of areas with tumour necrosis. A good correlation was found between the applied energy and the size of tumour necrosis at histopathology (Pearson = 0.76, p = 0.002).
  
  
  CONCLUSIONS
  Our results show that MR-HIFU ablation with the dedicated breast system is safe and results in histopathologically proven tumour necrosis.
  
  
  CONCLUSIONS
  • MR-HIFU ablation with the dedicated breast system is safe and feasible • In none of the patients was skin redness or burns observed • No correlation was found between the applied energy and the temperature increase • The correlation between applied energy and size of tumour necrosis was good.
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands. L.G.Merckel-2@umcutrecht.nl.
authors: Laura G
authors: LG
authors: Merckel
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.
authors: Floor M
authors: FM
authors: Knuttel
authors: Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Roel
authors: R
authors: Deckers
authors: Department of Surgery, Diakonessenhuis Utrecht, Utrecht, The Netherlands.
authors: Thijs
authors: T
authors: van Dalen
authors: Philips Healthcare, Best, The Netherlands.
authors: Gerald
authors: G
authors: Schubert
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.
authors: Nicky H G M
authors: NH
authors: Peters
authors: Department of Radiology, Diakonessenhuis Utrecht, Utrecht, The Netherlands.
authors: Teun
authors: T
authors: Weits
authors: Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Paul J
authors: PJ
authors: van Diest
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.
authors: Willem P Th M
authors: WP
authors: Mali
authors: Department of Anesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Paul H H B
authors: PH
authors: Vaessen
authors: Department of Pathology, Diakonessenhuis Utrecht, Utrecht, The Netherlands.
authors: Joost M H H
authors: JM
authors: van Gorp
authors: Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Chrit T W
authors: CT
authors: Moonen
authors: Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Lambertus W
authors: LW
authors: Bartels
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O. Box 85500, 3584 CX, Utrecht, The Netherlands.
authors: Maurice A A J
authors: MA
authors: van den Bosch
mesh_terms: D001940:Breast / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008875:Middle Aged; D016896:Treatment Outcome
keywords: Ablation; Breast cancer; High-intensity focused ultrasound; Magnetic resonance imaging; Minimally invasive treatment