title: Ophthalmological Assessment of OCT and Electrophysiological Changes in Migraine Patients.
abstract: BACKGROUND
  A cross-sectional study to investigate the morphological and functional changes of the visual pathway taking place in patients with migraine.
  
  
  METHODS
  Fifteen patients (14 female, 1 male) diagnosed with migraine with aura and 23 patients (21 female, 2 male) diagnosed with migraine without aura were compared with 20 healthy volunteers (18 female, 2 male). All the participants underwent optical coherence tomography scan, electroretinogram (ERG), visual evoked potentials, and multifocal electroretinogram (mf-ERG) recording.
  
  
  RESULTS
  Assessing ERG recordings, no significant differences in mean N1-P1 amplitudes were measured among the groups. The mean visual evoked potentials N80-P100 amplitudes were not significantly different among the three groups (one way analysis of variance: P = 0.075, F = 2.718). No significant difference was found in P100 latency times among groups. The mean retinal response density of mf-ERG in ring 1 was higher in healthy individuals compared with migraineurs, with statistical significance (Kruskal-Wallis analysis of variance and Dunn multiple comparisons test; P < 0.001, mean rank difference = -24.857 and P < 0.001, mean rank difference = -20.9, for migraine with aura-control and migraine without aura-control comparisons, respectively). In migraine with aura subjects, retinal nerve fiber layer thickness in superior and inferior quadrants was significantly decreased compared with healthy individuals, whereas in migraine without aura group, only the superior quadrant was significantly thinner compared with the control group.
  
  
  CONCLUSIONS
  Retinal response density in mfERG of all migraineurs was significantly lessened compared with healthy individuals. There was no significant difference in visual evoked potentials N80-P100 amplitudes or P100 latencies among the groups. Moreover, retinal nerve fiber layer thinning observed in patients with migraine compared with control subjects, appeared statistically significant in some quadrants. The authors may be able to defend the retinal blood flow decrease theory in migraine. The results also indicate that several levels of the visual pathway seem to be affected in migraineurs.
authors: *First Department of Ophthalmology, University of Athens, Athens, Greece; and †Laboratory of Electrophysiology, First Department of Ophthalmology, University of Athens, Athens, Greece.
authors: George V
authors: GV
authors: Verroiopoulos
authors: Eirini
authors: E
authors: Nitoda
authors: Ioannis D
authors: ID
authors: Ladas
authors: Dimitrios
authors: D
authors: Brouzas
authors: Dimitra
authors: D
authors: Antonakaki
authors: Marilita M
authors: MM
authors: Moschos
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004596:Electroretinography; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000473:pathology* / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012160:Retina / Q000473:pathology*; D018709:Statistics, Nonparametric; D041623:Tomography, Optical Coherence