title: Electrical impedance myography in facioscapulohumeral muscular dystrophy.
abstract: In this study we determined the reliability and validity of electrical impedance myography (EIM) in facioscapulohumeral muscular dystrophy (FSHD).
  
  
  
  We performed a prospective study of EIM on 16 bilateral limb and trunk muscles in 35 genetically defined and clinically affected FSHD patients (reliability testing on 18 patients). Summary scores based on body region were derived. Reactance and phase (50 and 100 kHz) were compared with measures of strength, FSHD disease severity, and functional outcomes.
  
  
  
  Participants were mostly men, mean age 53.0 years, and included a full range of severity. Limb and trunk muscles showed good to excellent reliability [intraclass correlation coefficients (ICC) 0.72-0.99]. Summary scores for the arm, leg, and trunk showed excellent reliability (ICC 0.89-0.98). Reactance was the most sensitive EIM parameter to a broad range of FSHD disease metrics.
  
  
  
  EIM is a reliable measure of muscle composition in FSHD that offers the possibility to serially evaluate affected muscles. Muscle Nerve 54: 696-701, 2016.
authors: Department of Neurology, University of Kansas Medical Center, 4330 Shawnee Mission Parkway, Ste. 323, Fairway, Kansas, 66205, USA. jstatland@kumc.edu.
authors: Jeffrey M
authors: JM
authors: Statland
authors: Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
authors: Chad
authors: C
authors: Heatwole
authors: Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
authors: Katy
authors: K
authors: Eichinger
authors: Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
authors: Nuran
authors: N
authors: Dilek
authors: Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
authors: William B
authors: WB
authors: Martens
authors: Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
authors: Rabi
authors: R
authors: Tawil
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology*; D020391:Muscular Dystrophy, Facioscapulohumeral / Q000175:diagnosis* / Q000503:physiopathology*; D009213:Myography / Q000379:methods; D011446:Prospective Studies
keywords: electrical impedance myography; facioscapulohumeral muscular dystrophy; muscle composition; muscular dystrophy; outcome measure