title: Prognostic role of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 in various cancers: A meta-analysis.
abstract: Several studies have investigated the correlation between the expression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and cancer prognosis, with inconsistent results. Therefore, a meta-analysis was conducted to identify the potential correlation after pooling data from eligible studies. PubMed/Medline, Web of Science and The Cochrane Library electronic databases were searched for eligible studies on the prognostic role of MALAT1 in cancer, from inception to January, 2015. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to summarize the effect. A total of 1,198 patients from 10 studies were included in the analysis. The results suggested that MALAT1 expression was significantly associated with overall survival (HR=2.07, 95% CI: 1.67-2.56), disease-free survival (HR=2.60, 95% CI: 1.69-4.00) and recurrence-free survival (HR=3.28, 95% CI: 1.52-7.09). MALAT1 was also found to be significantly associated with tumor size (P=0.013). Overall, MALAT1 expression may be considered as a potential prognostic factor for cancer patients.
authors: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China; The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Jin
authors: J
authors: Yan
authors: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China; The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Xiaoying
authors: X
authors: Zhou
authors: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China; The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Yini
authors: Y
authors: Dang
authors: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China; The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Chengqiang
authors: C
authors: Yin
authors: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China; The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors: Guoxin
authors: G
authors: Zhang
keywords: cancer; clinicopathological characteristics; meta-analysis; metastasis-associated lung adenocarcinoma transcript 1; prognosis