title: A Tutorial on RxODE: Simulating Differential Equation Pharmacometric Models in R.
abstract: This tutorial presents the application of an R package, RxODE, that facilitates quick, efficient simulations of ordinary differential equation models completely within R. Its application is illustrated through simulation of design decision effects on an adaptive dosing regimen. The package provides an efficient, versatile way to specify dosing scenarios and to perform simulation with variability with minimal custom coding. Models can be directly translated to Rshiny applications to facilitate interactive, real-time evaluation/iteration on simulation scenarios.
authors: Novartis Pharmaceuticals East Hanover New Jersey USA.
authors: W
authors: W
authors: Wang
authors: University of Georgia Athens Georgia USA.
authors: K M
authors: KM
authors: Hallow
authors: Novartis Pharmaceuticals East Hanover New Jersey USA.
authors: D A
authors: DA
authors: James
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D054796:Drug Dosage Calculations; D008958:Models, Molecular; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012984:Software
chemical_list: D004364:Pharmaceutical Preparations