title: Low-level laser therapy versus 5% amlexanox: a comparison of treatment effects in a cohort of patients with minor aphthous ulcers.
abstract: OBJECTIVE
  The aim of the study was to compare the treatment effects of 5% amlexanox and low-level laser therapy (LLLT) in a cohort of patients who experienced minor aphthous stomatitis.
  
  
  METHODS
  A clinical trial was performed between 2012 and 2014 on 50 participants having minor aphthous ulcers. Group A participants were treated with amlexanox oral paste (lexanox 5% oral paste), and group B participants were treated with LLLT. Pain scores and sizes of ulcers were measured on the first, third, and seventh days of treatment in both groups. Data were analyzed using paired t test and independent t test.
  
  
  RESULTS
  No significant difference was observed between the two groups with respect to pain level on the first and seventh days of treatment.
  
  
  CONCLUSIONS
  Both amlexanox and LLLT were equally effective in relieving pain associated with minor aphthous stomatitis. Both groups showed significant reduction in ulcer sizes and in pain scores.
authors: Department of Oral Medicine & Radiology, Coorg Institute of Dental Sciences, Virajpet, Coorg District, Karnataka State, India. Electronic address: Drjijin@gmail.com.
authors: Mekkadath Jayakrishnan
authors: MJ
authors: Jijin
authors: Professor and HOD, Department of Oral Medicine & Radiology, Coorg Institute of Dental Sciences, Virajpet, Coorg District, Karnataka State, India.
authors: Mangala
authors: M
authors: Rakaraddi
authors: Professor, Department of Periodontics, Coorg Institute of Dental Sciences, Virajpet, Coorg District, Karnataka State, India.
authors: Jagadish
authors: J
authors: Pai
authors: Professor, Department of Oral Medicine & Radiology, JSS Dental College, Mysore, Karnataka State, India.
authors: Hombarvali Puttabuddi
authors: HP
authors: Jaishankar
authors: Reader, Department of Oral Medicine & Radiology, Coorg Institute of Dental Sciences, Virajpet, Coorg District, Karnataka State, India.
authors: Rangaswamy
authors: R
authors: Krupashankar
authors: Senior Lecturer, Department of Oral Medicine & Radiology, Coorg Institute of Dental Sciences, Virajpet, Coorg District, Karnataka State, India.
authors: Ankanathapura Puthaswamy
authors: AP
authors: Kavitha
authors: Medical officer ECHS, Virajpet, Coorg District, Karnataka State, India.
authors: Ramachandran
authors: R
authors: Anjana
authors: Department of Oral Medicine & Radiology, Coorg Institute of Dental Sciences, Virajpet, Coorg District, Karnataka State, India.
authors: Raju
authors: R
authors: Shobha
mesh_terms: D000293:Adolescent; D000328:Adult; D000631:Aminopyridines / Q000627:therapeutic use*; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007194:India; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D013281:Stomatitis, Aphthous / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000631:Aminopyridines; D018926:Anti-Allergic Agents; C045742:amlexanox