title: Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage.
abstract: OBJECTIVE
  We tested the hypothesis that intraventricular hemorrhage (IVH) is associated with incontinence and gait disturbance among survivors of intracerebral hemorrhage (ICH) at 3-month follow-ups.
  
  
  METHODS
  The Genetic and Environmental Risk Factors for Hemorrhagic Stroke study was used as the discovery set. The Ethnic/Racial Variations of Intracerebral Hemorrhage study served as a replication set. Both studies performed prospective hot-pursuit recruitment of ICH cases with 3-month follow-up. Multivariable logistic regression analyses were computed to identify risk factors for incontinence and gait dysmobility at 3 months after ICH.
  
  
  RESULTS
  The study population consisted of 307 ICH cases in the discovery set and 1,374 cases in the replication set. In the discovery set, we found that increasing IVH volume was associated with incontinence (odds ratio [OR] 1.50; 95% confidence interval [CI] 1.10-2.06) and dysmobility (OR 1.58; 95% CI 1.17-2.15) after controlling for ICH location, initial ICH volume, age, baseline modified Rankin Scale score, sex, and admission Glasgow Coma Scale score. In the replication set, increasing IVH volume was also associated with both incontinence (OR 1.42; 95% CI 1.27-1.60) and dysmobility (OR 1.40; 95% CI 1.24-1.57) after controlling for the same variables.
  
  
  CONCLUSIONS
  ICH subjects with IVH extension are at an increased risk for developing incontinence and dysmobility after controlling for factors associated with severity and disability. This finding suggests a potential target to prevent or treat long-term disability after ICH with IVH.
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL. woodl@ucmail.uc.edu.
authors: Daniel
authors: D
authors: Woo
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Andrew J
authors: AJ
authors: Kruger
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Padmini
authors: P
authors: Sekar
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Mary
authors: M
authors: Haverbusch
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Jennifer
authors: J
authors: Osborne
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Charles J
authors: CJ
authors: Moomaw
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Sharyl
authors: S
authors: Martini
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Shahla M
authors: SM
authors: Hosseini
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Simona
authors: S
authors: Ferioli
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Bradford B
authors: BB
authors: Worrall
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Mitchell S V
authors: MS
authors: Elkind
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Gene
authors: G
authors: Sung
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Michael L
authors: ML
authors: James
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Fernando D
authors: FD
authors: Testai
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Carl D
authors: CD
authors: Langefeld
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Joseph P
authors: JP
authors: Broderick
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Sebastian
authors: S
authors: Koch
authors: From the Department of Neurology and Rehabilitation Medicine (D.W., A.J.K., P.S., M.H., J.O., C.J.M., S.M.H., S.F., J.P.B., M.L.F.), University of Cincinnati College of Medicine, OH; Department of Neurology (S.M.), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville; Department of Neurology (M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (G.S.), University of Southern California, Los Angeles; Departments of Anesthesiology and Neurology (M.L.J.), Duke University, Durham, NC; Departments of Neurology and Rehabilitation (F.D.T.), University of Illinois at Chicago; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; and Miller School of Medicine (S.K.), University of Miami, FL.
authors: Matthew L
authors: ML
authors: Flaherty
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000453:epidemiology; D002552:Cerebral Ventricles / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D020233:Gait Disorders, Neurologic / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000175:diagnosis* / Q000453:epidemiology