title: Transcription factor gene GATA2: Association of leukemia and nonsynonymous to the synonymous substitution rate across five mammals.
abstract: GATA2 gene encodes a member of the GATA family of zinc-finger transcription factors that play a pivotal role during the transition of primitive blood forming cells into white blood cells. Mutation in GATA2 results in the loss of function or even gain of function, including abnormal proliferation of white blood cells that may predispose to acute myeloid leukemia. Our results showed that the codon usage in GATA2 has been influenced by GC mutation bias where nature has highly favored fourteen most over represented codons but disfavored the ATA codon across five mammals. Purifying natural selection has affected GATA2 gene in human and other mammals to maintain its protein function during the period of evolution. Our findings report an insight into the codon usage patterns in gaining the clues for codon optimization to alter the translational efficiency as well as for the functional conservation of gene expression and the significance of nucleotide composition in GATA2 gene within mammals.
authors: Department of Biotechnology, Assam University, Silchar 788011, Assam, India.
authors: Tarikul Huda
authors: TH
authors: Mazumder
authors: Department of Biotechnology, Assam University, Silchar 788011, Assam, India.
authors: Arif
authors: A
authors: Uddin
authors: Department of Biotechnology, Assam University, Silchar 788011, Assam, India. Electronic address: supriyoch_2008@rediffmail.com.
authors: Supriyo
authors: S
authors: Chakraborty
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000235:genetics; D000818:Animals; D001482:Base Composition; D002417:Cattle; D003062:Codon; D050989:GATA2 Transcription Factor / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D008322:Mammals / Q000235:genetics*; D051379:Mice; D051381:Rats; D012641:Selection, Genetic; D000069456:Silent Mutation; D034421:Sus scrofa
chemical_list: D000596:Amino Acids; D003062:Codon; D050989:GATA2 Transcription Factor
keywords: Amino acid substitution; GATA2; Mutation rate; Transcription factor