title: Cytomegalovirus Enterocolitis in Immunocompetent Young Children: A Report of Two Cases and Review of the Literature.
abstract: Cytomegalovirus (CMV) causes significant morbidity and mortality in congenitally infected children and immunocompromised hosts. Among healthy individuals, CMV is generally thought to cause mild, self-limited illness. CMV enterocolitis, in particular, is rarely considered among immunocompetent children presenting with diarrhea. We describe 2 cases of invasive CMV colitis in immunocompetent infants presenting with diarrhea and review the literature to date on this topic. Although invasive CMV enterocolitis has been sporadically reported among immunocompetent children, it remains an underrecognized cause of infectious diarrhea in this population and indications for antiviral therapy are lacking. We propose that CMV should be included in the differential diagnosis of intractable diarrhea in immunocompetent children.
authors: From the *Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland; †Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; ‡Division of Microbiology, Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland; §Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee; and ¶Department of Pathology, Hofstra Northwell School of Medicine, Lake Success, New York.
authors: Paul K
authors: PK
authors: Sue
authors: Nicole M
authors: NM
authors: Salazar-Austin
authors: Oliver G
authors: OG
authors: McDonald
authors: Arvind
authors: A
authors: Rishi
authors: Toby C
authors: TC
authors: Cornish
authors: Ravit
authors: R
authors: Arav-Boger
mesh_terms: D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*; D003967:Diarrhea / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D004760:Enterocolitis / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male