title: Stereoselective organocatalytic oxidation of alcohols to enals: a homologation method to prepare polyenes.
abstract: A novel method for organocatalytic oxidation through oxidative enamine catalysis was developed with excellent compatibility for the direct syntheses of enals from simple saturated alcohols. By using this amine-catalyzed IBX-oxidation, a wide range of aromatic and aliphatic substituted enals were successfully generated in high yields and exclusively stereoselective E-geometry. Moreover, varying the solvents and/or the loading amounts of IBX allowed for the selective oxidation of alcohols and aldehydes. Importantly, the homologous application of this method provided a selective and efficient way of preparing various highly sensitive conjugated polyene frameworks, which are enriched in natural products.
authors: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases & Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, 199 Ren'ai Road, Suzhou 215123, China. zhangshilei@suda.edu.cn.
authors: Xiaobei
authors: X
authors: Chen
authors: Yinan
authors: Y
authors: Zhang
authors: Huixin
authors: H
authors: Wan
authors: Wei
authors: W
authors: Wang
authors: Shilei
authors: S
authors: Zhang