title: Application of buccal fat pad-derived stem cells in combination with autogenous iliac bone graft in the treatment of maxillomandibular atrophy: a preliminary human study.
abstract: Stem cell therapy for the treatment of bone defects is an alternative or adjunct to autologous bone grafting. This study assessed the efficacy of buccal fat pad-derived stem cells (BFPSCs) with iliac bone block grafting for the treatment of extensive human alveolar ridge defects. Eight patients with extensive jaw atrophy were selected for this study. The jaws were reconstructed with non-vascularized anterior iliac crest bone blocks. Gaps between the blocks were filled with freeze-dried bone granules and covered with a collagen membrane. In the test group (n=4), these granules were seeded with BFPSCs. Cone beam computed tomography scans were used to assess the amount of new bone formed at six sites in each patient. Trephine biopsies of 2-mm were also taken from the graft site during implant placement for histomorphometric analysis. The mean bone width change at the graft site was greater in the test group than in the control group (3.94±1.62mm vs. 3.01±0.89mm). New bone formation was 65.32% in the test group versus 49.21% in the control group. The application of BFPSCs in conjunction with iliac bone block grafts may increase the amount of new bone formation and decrease secondary bone resorption in extensively atrophic jaws.
authors: Dental Research Centre, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran; School of Medicine, University of Antwerp, Antwerp, Belgium. Electronic address: arashkhojasteh@sbmu.ac.ir.
authors: A
authors: A
authors: Khojasteh
authors: Dental Research Centre, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: N
authors: N
authors: Sadeghi
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000328:Adult; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001284:Atrophy / Q000601:surgery; D016025:Bone Transplantation; D003758:Dental Implantation, Endosseous; D005260:Female; D006801:Humans; D007085:Ilium / Q000637:transplantation*; D008297:Male; D008334:Mandible / Q000473:pathology* / Q000601:surgery; D008437:Maxilla / Q000473:pathology* / Q000601:surgery; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells
keywords: bone defect; bone graft; mesenchymal stem cell; regenerative medicine; tissue engineering