title: Modified alginate and gelatin cross-linked hydrogels for soft tissue adhesive.
abstract: Soft tissue adhesives made from natural hydrogel are attractive in clinical applications due to their excellent properties, such as high water content, good biocompatibility, low immune, good biodegradability. Hydrogels derived from natural polysaccharides and proteins are ideal components for soft tissue adhesive since they resemble the extracellular matrices of the tissue composed of various sugar and amino acids-based macromolecules. In this paper, a series of novel tissue adhesives mixed by aldehyde sodium alginate (ASA) with amino gelatin (AG) were developed and characterized. The effect of aldehyde content in ASA and amino group content in AG on the properties of ASA/AG cross-linked hydrogel was measured. The results showed the gelling time, swelling behavior and the bonding strength of the hydrogel can be tuned by varying the content of aldehyde groups in ASA and the content of amino groups in AG. The gelation time could be controlled within 4-18 min. When the aldehyde content of ASA is 75.24% and the amino content of AG is 0.61 mmol/g, the hydrogel almost has the adhesive strength equal to the commercially available adhesive ﬁbrin glue. So, this tunable ASA/AG hydrogels in this study could be a promising candidate as soft tissue adhesive and have a wide range of biomedical applications.
authors: a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials , College of Materials Science and Engineering, Donghua University , Shanghai , China.|b Biomaterials and Tissue Engineering Lab , College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai , China.
authors: Liu
authors: L
authors: Yuan
authors: b Biomaterials and Tissue Engineering Lab , College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai , China.
authors: Yu
authors: Y
authors: Wu
authors: a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials , College of Materials Science and Engineering, Donghua University , Shanghai , China.|b Biomaterials and Tissue Engineering Lab , College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai , China.
authors: Jun
authors: J
authors: Fang
authors: c Shandong Enoch Biotechnology , Shandong , China.
authors: Xiaojuan
authors: X
authors: Wei
authors: c Shandong Enoch Biotechnology , Shandong , China.
authors: Qisheng
authors: Q
authors: Gu
authors: d Department of Chemistry , College of Science, King Saud University , Riyadh , Kingdom of Saudi Arabia.|e Department of Chemistry, Faculty of Science , Tanta University , Tanta , Egypt.
authors: Hany
authors: H
authors: El-Hamshary
authors: d Department of Chemistry , College of Science, King Saud University , Riyadh , Kingdom of Saudi Arabia.
authors: Salem S
authors: SS
authors: Al-Deyab
authors: f Faculty of Engineering and Industry Science , Swinburne University of Technology , Melbourne , VIC , Australia.
authors: Yosry
authors: Y
authors: Morsi
authors: a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials , College of Materials Science and Engineering, Donghua University , Shanghai , China.|b Biomaterials and Tissue Engineering Lab , College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai , China.
authors: Xiumei
authors: X
authors: Mo
mesh_terms: D000464:Alginates / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D020723:Glucuronic Acid / Q000737:chemistry / Q000494:pharmacology; D006603:Hexuronic Acids / Q000737:chemistry / Q000494:pharmacology; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice; D014014:Tissue Adhesives / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020100:Hydrogels; D014014:Tissue Adhesives; D020723:Glucuronic Acid
keywords: Biodegradable; hydrogel; modified alginate polymer; tissue adhesive