title: Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females.
abstract: This study evaluated the effect of moderate weight loss on the incidence of knee osteoarthritis (OA) in middle-aged overweight and obese women, without clinical and radiologic knee OA at baseline.
  
  
  
  A total of 353 women (87%) with followup data available were selected from the Prevention of Knee Osteoarthritis in Overweight Females study, which evaluated the preventive effect of a diet and exercise intervention and of oral glucosamine sulfate on the incidence of knee OA. This was an exploratory proof-of-concept analysis, which compared the incidence of knee OA between women who reached the clinically relevant weight loss target of 5 kg or 5% of body weight after 30 months and those who did not reach this target.
  
  
  
  The weight loss group showed a significantly lower incidence of knee OA according to the primary outcome measure, which was composed of the American College of Rheumatology criteria (clinical and radiographic), Kellgren/Lawrence grade ≥2, and joint space narrowing ≥1.0 mm (15% versus 20%; odds ratio 0.5, 95% confidence interval 0.3-0.9). Moreover, the weight loss also positively affected several health measures, such as blood glucose level, body fat percentage, and blood pressure.
  
  
  
  A reduction of ≥5 kg or 5% of body weight over a 30-month period reduces the risk for the onset of radiographic knee OA in middle-aged overweight and obese women. Because of the slow progression of the disease, a longer followup period will be necessary before the number of prevented cases of knee OA by moderate weight loss becomes clinically more relevant.
authors: Erasmus Medical Center, Rotterdam, The Netherlands. j.runhaar@erasmusmc.nl.
authors: Jos
authors: J
authors: Runhaar
authors: Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Bastiaan C
authors: BC
authors: de Vos
authors: Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Marienke
authors: M
authors: van Middelkoop
authors: Maasstad Hospital, Rotterdam, The Netherlands.
authors: Dammis
authors: D
authors: Vroegindeweij
authors: Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Edwin H G
authors: EH
authors: Oei
authors: Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Sita M A
authors: SM
authors: Bierma-Zeinstra
mesh_terms: D001835:Body Weight; D004038:Diet, Reducing / Q000379:methods*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005944:Glucosamine / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D020370:Osteoarthritis, Knee / Q000209:etiology / Q000517:prevention & control*; D050177:Overweight / Q000150:complications*; D012307:Risk Factors; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D005944:Glucosamine