title: Serum cross-linked N-telopeptide of type I collagen for the diagnosis of bone metastases from solid tumours in the Chinese population: Meta-analysis.
abstract: OBJECTIVE
  A meta-analysis to determine the diagnostic value of serum cross-linked N-telopeptide of type I collagen (NTx) for bone metastasis from solid tumours in the Chinese population.
  
  
  METHODS
  Eligible case-control studies published up until 22 September 2014 were identified by searching the electronic literature databases PubMed®, Web of Science, China National Knowledge Infrastructure and Wanfang using the keyword 'NTx' in combination with 'cancer'. A meta-analysis of the diagnostic value of serum NTx for bone metastasis from solid tumours was undertaken.
  
  
  RESULTS
  The meta-analysis included 14 studies (1279 patients: 668 with bone metastasis; 611 controls without bone metastasis). There was a significant relationship between serum NTx concentration and bone metastasis from solid tumours in the Chinese population (odds ratio 1.39, 95% confidence intervals 1.26, 1.51). Significant heterogeneity was found in this study, but no publication bias was observed.
  
  
  CONCLUSIONS
  Serum NTx concentration may play an important role in the diagnosis of bone metastasis from solid tumours in the Chinese population.
authors: ICU Centre, The Second Xiangya Hospital, Central South University, Furong, Changsha, Hunan Province, China.
authors: Yudong
authors: Y
authors: Zhang
authors: The State Key Laboratory of Medical Genetics, Department of Medical Informatics, Central South University, Changsha, Hunan Province, China.
authors: Minhan
authors: M
authors: Yi
authors: Department of Respiratory Medicine, Anhui Provincial Hospital, Hefei, Anhui Province, China.
authors: Jie
authors: J
authors: Cao
authors: ICU Centre, The Second Xiangya Hospital, Central South University, Furong, Changsha, Hunan Province, China.
authors: Can
authors: C
authors: Hou
authors: ICU Centre, The Second Xiangya Hospital, Central South University, Furong, Changsha, Hunan Province, China.
authors: Yanyan
authors: Y
authors: Zhou
authors: ICU Centre, The Second Xiangya Hospital, Central South University, Furong, Changsha, Hunan Province, China zhongyanjun2@163.com.
authors: Yanjun
authors: Y
authors: Zhong
mesh_terms: D044466:Asian People; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics / Q000556:secondary; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics / Q000473:pathology; D024042:Collagen Type I / Q000097:blood / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics / Q000473:pathology; D008297:Male; D016017:Odds Ratio; D010455:Peptides / Q000097:blood / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics / Q000473:pathology; D012306:Risk
chemical_list: D014408:Biomarkers, Tumor; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide
keywords: Serum cross-linked N-telopeptide of type I collagen (NTx); bone metastasis; meta-analysis; solid tumour