title: [Proteomics and PCOS: Is it here the missing link? Literature review].
abstract: Polycystic ovary syndrome (PCOS) is known as a common gynecologic and endocrinology disease with multiple short and long-term consequences. It is one of the most common causes for hyperandrogenism and anovulation, increases the risk for metabolic syndrome, type 2 diabetes and cardiovascular disease. Its etiology remains unclear. PCOS is thought to be the result of the interaction between predisposing genetic variants with environmental factors and strongly depends on ethnicity. Proteomics allows the study of several hundreds or thousands of proteins in order to reveal physiological state of a tissue or an organ at the molecular level and to identify disease-specific biomarkers. Its use on PCOS patients will permit us to identify molecules that are involved in the PCOS pathology so we can develop specific diagnostic and management approaches.
authors: Israel Obed
authors: IO
authors: Carmona-Ruiz
authors: Eric
authors: E
authors: Saucedo de la Llata
authors: Maria Rosa
authors: MR
authors: Moraga-Sánchez
authors: Maria Luisa
authors: ML
authors: Hernáez-Sánchez
authors: Maria Dolores
authors: MD
authors: Gutiérrez-Blázquez
authors: Alberto
authors: A
authors: Romeu-Sarrió
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000209:etiology / Q000503:physiopathology*; D040901:Proteomics / Q000379:methods*
chemical_list: D015415:Biomarkers