title: Self-dispersible nanocrystals of albendazole produced by high pressure homogenization and spray-drying.
abstract: Albendazole (ABZ) is a broad-spectrum antiparasitic drug used in the treatment of human or animal infections. Although ABZ has shown a high efficacy for repeated doses in monogastric mammals, its low aqueous solubility leads to erratic bioavailability. The aim of this work was to optimize a procedure in order to obtain ABZ self-dispersible nanocrystals (SDNC) by combining high pressure homogenization (HPH) and spray-drying (SD). The material thus obtained was characterized and the variables affecting both the HPH and SD processes were studied. As expected, the homogenizing pressure and number of cycles influenced the final particle size, while the stabilizer concentration had a strong impact on SD output and redispersion of powders upon contact with water. ABZ SDNC were successfully obtained with high process yield and redispersibility. The characteristic peaks of ABZ were clearly identified in the X-ray patterns of the processed samples. A noticeable increase in the dissolution rate was observed in the aqueous environment.
authors: a Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, UNITEFA (CONICET) , Córdoba , Argentina ;|b Departamento de Farmacia , Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Córdoba , Argentina ;
authors: Alejandro Javier
authors: AJ
authors: Paredes
authors: a Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, UNITEFA (CONICET) , Córdoba , Argentina ;|b Departamento de Farmacia , Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Córdoba , Argentina ;
authors: Juan Manuel
authors: JM
authors: Llabot
authors: c Laboratorio de Farmacología, Facultad de Ciencias Veterinarias , CIVETAN (CONICET), Universidad del Centro de la Provincia de Buenos Aires, Campus Universitario , Tandil , Buenos Aires , Argentina.
authors: Sergio
authors: S
authors: Sánchez Bruni
authors: a Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, UNITEFA (CONICET) , Córdoba , Argentina ;|b Departamento de Farmacia , Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Córdoba , Argentina ;
authors: Daniel
authors: D
authors: Allemandi
authors: a Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, UNITEFA (CONICET) , Córdoba , Argentina ;|b Departamento de Farmacia , Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Córdoba , Argentina ;
authors: Santiago Daniel
authors: SD
authors: Palma
mesh_terms: D015766:Albendazole / Q000737:chemistry*; D001682:Biological Availability; D003890:Desiccation; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011208:Powders / Q000737:chemistry; D011312:Pressure; D012995:Solubility
chemical_list: D005079:Excipients; D011208:Powders; D015766:Albendazole
keywords: Albendazole; enhanced dissolution rate; high pressure homogenization; nanocrystals; pluronic 188; poloxamer 188; poor solubility; spray drying