title: Mechanisms of SNR and line shape improvement by B0correction in overdiscrete MRSI reconstruction.
abstract: Inhomogeneities of the main magnetic field cause line broadening and location-dependent frequency shifts in brain MRSI. These are often visible despite advanced B0shimming. The purpose of this work is to propose an advanced B0correction method that can easily be applied during postprocessing.
  
  
  
  A target-driven overdiscrete reconstruction method previously introduced for MRSI is modified by dividing it into two steps. In a first step, an intermediate spectroscopic image with arbitrarily high resolution is generated, on which B0correction is performed as an additional processing step based on an additionally acquired B0map. This frequency-aligns metabolite peaks and destroys noise correlations between neighboring subvoxels. Second, the voxel is shaped by application of the spatial response target. The method was tested with simulated spectroscopic imaging data as well as in a series of MRSI data sets obtained from four healthy volunteers at 7T.
  
  
  
  A systematic gain in spectral signal-to-noise ratio is achieved, due to spatial averaging now occurring over peak aligned and noise decorrelated subvoxel spectra. At the same time, metabolite peak line widths are reduced.
  
  
  
  In the presence of B0inhomogeneities across the field of view, the proposed method offers the potential to improve spectral quality with only a minimal additional effort during acquisition. Magn Reson Med 77:44-56, 2017. © 2015 Wiley Periodicals, Inc.
authors: Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
authors: Thomas
authors: T
authors: Kirchner
authors: Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
authors: Ariane
authors: A
authors: Fillmer
authors: Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.|Max Planck Institute for Biological Cybernetics, Tuebingen, Germany.
authors: Anke
authors: A
authors: Henning
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D059629:Signal-To-Noise Ratio
keywords: B0 correction; magnetic resonance spectroscopic imaging; signal-to-noise ratio