title: Cytotoxic nor-dammarane triterpenes from Viburnum hainanense Merr. et Chun.
abstract: Five new nor-dammarane triterpenes, 12β-O-acetyl-17β-hydoxy-3,15-dioxo-20,21,22,23,24,25,26,27-octanordammanran (1), 12β-hydoxy-17β-methoxy-3,15-dioxo-20,21,22,23,24,25,26,27-octanordammanran (2), 12β-O-acetyl-3,15-dioxo-17-en-20,21,22,23,24,25,26,27-octanordammanran (3), 12β-hydoxy-15α-O-acetyl-3-oxo-17-en-20,21,22,23,24,25,26,27-octanordammanran (4) and 3β-hydoxy-17-oxo-12-en-20,21,22,23,24,25,26,27-octanordammanran (5), were obtained from the ethanol extract of the whole plants of Viburnum hainanense Merr. et Chun. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D NMR, IR, UV, and HRESIMS. The isolated compounds were tested in vitro for cytotoxic potential against seven tumor cell lines (Hep-2, SCL-1, CAL-27, UMSCC-1, Detroit-562, SCC-PKU, and TCA-83). As result, compounds 1 and 2 exhibited cytotoxic activities with IC50 values less than 10 μM.
authors: Department of gastroenterology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 110042, China.
authors: Wei
authors: W
authors: Wang
authors: Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China.
authors: Juan
authors: J
authors: Song
authors: Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China. Electronic address: gbshi@sohu.com.
authors: GuoBing
authors: G
authors: Shi
authors: Department of gastroenterology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 110042, China. Electronic address: qinggong_yu@163.com.
authors: QingGong
authors: Q
authors: Yu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D027925:Viburnum / Q000737:chemistry*; D000097669:Dammaranes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; D000097669:Dammaranes
keywords: Caprifoliaceae; Cytotoxicity; Nor-dammarane triterpenes; Viburnum hainanense