title: Compacting Chromatin to Ensure Muscle Satellite Cell Quiescence.
abstract: Satellite cells comprise a pool of quiescent stem cells that repair muscle damage, but the mechanisms enforcing their quiescence are poorly defined. In this issue of Cell Stem Cell, Boonsanay et al. (2016) show that the histone methyltransferase Suv4-20H1 maintains satellite cell quiescence by promoting a heterochromatic state through transcriptional repression of the myogenic master regulator MyoD.
authors: Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
authors: Yuefeng
authors: Y
authors: Li
authors: Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. Electronic address: jdilworth@ohri.ca.
authors: F Jeffrey
authors: FJ
authors: Dilworth
mesh_terms: D002454:Cell Differentiation; D002843:Chromatin; D006801:Humans; D018482:Muscle, Skeletal; D032496:Satellite Cells, Skeletal Muscle; D013234:Stem Cells
chemical_list: D002843:Chromatin