title: Sibling cord blood donor program for hematopoietic cell transplantation: the 20-year experience in the Rome Cord Blood Bank.
abstract: Umbilical cord blood (UCB) represents a source of hematopoietic stem cells for patients lacking a suitably matched and readily available related or unrelated stem cell donor. As UCB transplantation from compatible sibling provides good results in children therefore directed sibling UCB collection and banking is indicated in family who already have a child with a disease potentially treatable with an allogeneic hematopoietic stem cell transplantation. Particularly, related UCB collection is recommended when the patients urgently need a transplantation. To provide access to all patients in need, we developed a "Sibling cord blood donor program for hematopoietic cell transplantation". Here we report results of this project started 20years ago. To date, in this study a total of 194 families were enrolled, a total of 204 UCB samples were successfully collected and 15 pediatric patients have been transplanted. Recently, some authors have suggested novel role for UCB other than in the transplantation setting. Therefore, future studies in the immunotherapy and regenerative medicine areas could expand indication for sibling directed UCB collection.
authors: Immunohaematology and Transfusion Medicine Unit, Azienda Policlinico Umberto I, Via Chieti N 7, 00161 Rome, Italy. Electronic address: bancasanguecordonale@bce.uniroma1.it.
authors: Maria
authors: M
authors: Screnci
authors: Immunohaematology and Transfusion Medicine Unit, Azienda Policlinico Umberto I, Via Chieti N 7, 00161 Rome, Italy.
authors: Emilia
authors: E
authors: Murgi
authors: Immunohaematology and Transfusion Medicine Unit, Azienda Policlinico Umberto I, Via Chieti N 7, 00161 Rome, Italy.
authors: Veronica
authors: V
authors: Valle
authors: Immunohaematology and Transfusion Medicine Unit, Ospedale S. Eugenio, P.le dell'Umanesimo n10, 00144 Rome, Italy. Electronic address: tamburini.anna@aslrmc.it.
authors: Anna
authors: A
authors: Tamburini
authors: Obstetrics and Gynecology Unit, Ospedale S Giovanni Calibita, Piazza Fatebenefratelli n2, 00186 Rome, Italy. Electronic address: dir.ostgin.fbf@virgilio.it.
authors: Maria Grazia
authors: MG
authors: Pellegrini
authors: Obstetrics and Gynecology Unit, Ospedale S Pertini, Via dei Monti Tiburtini n 385, 00157 Rome, Italy. Electronic address: sabrina.strano@aslromab.it.
authors: Sabrina
authors: S
authors: Strano
authors: Immunohaematology and Transfusion Medicine Unit, Azienda Policlinico Umberto I, Via Chieti N 7, 00161 Rome, Italy.
authors: Francesca
authors: F
authors: Corona
authors: Immunohaematology and Transfusion Medicine Unit, Azienda Policlinico Umberto I, Via Chieti N 7, 00161 Rome, Italy.
authors: Eleonora Barbacci
authors: EB
authors: Ambrogi
authors: Immunohaematology and Transfusion Medicine Unit, Azienda Policlinico Umberto I, Via Chieti N 7, 00161 Rome, Italy.
authors: Gabriella
authors: G
authors: Girelli
mesh_terms: D000293:Adolescent; D001771:Blood Banks / Q000266:history*; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation / Q000266:history* / Q000379:methods; D005260:Female; D005312:Fetal Blood / Q000166:cytology* / Q000276:immunology; D019337:Hematologic Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000266:history* / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology; D006453:Hemoglobinopathies / Q000276:immunology / Q000473:pathology / Q000628:therapy; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007223:Infant; D007558:Italy; D008297:Male; D035781:Siblings; D061349:Unrelated Donors
keywords: Alternative donor; Family-directed cord blood banking; Related cord blood banking; Stem cell transplantation; Umbilical cord blood transplantation