title: [Dualistic classification of epithelial ovarian cancer: Is it clinically relevant?].
abstract: Malignant epithelial tumors (carcinomas) are the most common ovarian cancers and the most lethal gynecological malignancies. Based on their heterogeneous morphology, a dualistic model of carcinogenesis was proposed in 2004. Type I carcinomas, composed of low grade serous, endometrioid, mucinous, clear cell carcinomas and malignant Brenner tumors, were distinct from type II carcinomas (high grade serous, undifferentiated carcinomas and carcinosarcomas). However, clinical studies failed to demonstrate the prognostic value of such a classification. The main reproach to this dualistic model was that it lumped together in type I tumors, heterogeneous lesions such as clear cell and mucinous carcinomas. Recent advances on molecular genetic alterations and precursor lesions favor the classification of ovarian carcinomas as five distinct diseases. The dualistic model of carcinogenesis in type I and II can finally be applied only to serous ovarian carcinomas (low grade and high grade).
authors: Hôpital de la Croix-Rousse, service de pathologie Nord, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France. Electronic address: Mojgan.devouassoux@chu-lyon.fr.
authors: Mojgan
authors: M
authors: Devouassoux-Shisheboran
authors: Gustave-Roussy, département de biopathologie, 39, rue Camille-Desmoulins, 94805 Villejuif cedex, France.
authors: Catherine
authors: C
authors: Genestie
authors: Centre Léon-Bérard, service d'oncologie médicale, 28, rue Laennec, 69008 Lyon, France.
authors: Isabelle
authors: I
authors: Ray-Coquard
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D001948:Brenner Tumor / Q000473:pathology; D018269:Carcinoma, Endometrioid / Q000473:pathology; D000077216:Carcinoma, Ovarian Epithelial; D002296:Carcinosarcoma / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000473:pathology; D005260:Female; D006801:Humans; D009154:Mutation; D009375:Neoplasms, Glandular and Epithelial / Q000145:classification* / Q000235:genetics / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000145:classification* / Q000235:genetics / Q000473:pathology*
keywords: Carcinomas; Carcinomes; Classification; Heterogeneous; Histologie; Histology; Hétérogénéité; Ovaire; Ovary