title: A novel zinc(II) and hydrogen sulphate selective fluorescent "turn-on" chemosensor based on isonicotiamide: INHIBIT type's logic gate and application in cancer cell imaging.
abstract: We have developed a novel isonicotiamide-based fluorescent "turn-on" chemosensor 1 for the selective detection of Zn(2+) and HSO4(-). The sensor 1 can detect Zn(2+) and HSO4(-) with a detection limit down to the nanomolar level by forming a complex in 1 : 1 stoichiometry in the presence of other anions and 2 : 1 in presence of cations in aqueous solution. Density functional theory calculations on 1 and the 1-Zn(2+)/HSO4(-) complexes are consistent with the experimental results. We have successfully utilized the above cation and anion for the fabrication of INHIBIT molecular logic gates. Furthermore the receptor 1 successfully detected the Zn(2+) and HSO4(-) ions in HeLa cells cultured in Zn(2+) and HSO4(-) enriched medium.
authors: School of Chemical Sciences, North Maharashtra University, Jalgaon-425001, MS, India. kuwaras@gmail.com kundantayade@gmail.com.
authors: Kundan
authors: K
authors: Tayade
authors: Molecular Biology and Human Genetics Laboratory, Department of Zoology, The University of Burdwan, Burdwan, West Bengal, India.
authors: Banashree
authors: B
authors: Bondhopadhyay
authors: Department of Chemistry, Indian Institute of Science Education and Research, Bhopal- 462 066, Madhya Pradesh, India.
authors: Karunesh
authors: K
authors: Keshav
authors: Department of Applied Chemistry, SV National Institute of Technology, Surat-395007, Gujrat, India.
authors: Suban K
authors: SK
authors: Sahoo
authors: Molecular Biology and Human Genetics Laboratory, Department of Zoology, The University of Burdwan, Burdwan, West Bengal, India.
authors: Anupam
authors: A
authors: Basu
authors: Department of Chemistry, Indian Institute of Technology, Ropar, Rupanagar, Punjab, India.
authors: Jasmider
authors: J
authors: Singh
authors: Department of Chemistry, Indian Institute of Technology, Ropar, Rupanagar, Punjab, India.
authors: Narinder
authors: N
authors: Singh
authors: Department of Chemistry, M.J College, Jalgaon-425001, MS, India.
authors: Dileep T
authors: DT
authors: Nehete
authors: School of Chemical Sciences, North Maharashtra University, Jalgaon-425001, MS, India. kuwaras@gmail.com kundantayade@gmail.com.
authors: Anil
authors: A
authors: Kuwar