title: Disordered haematopoiesis and athero-thrombosis.
abstract: Atherosclerosis, the major underlying cause of cardiovascular disease, is characterized by a lipid-driven infiltration of inflammatory cells in large and medium arteries. Increased production and activation of monocytes, neutrophils, and platelets, driven by hypercholesterolaemia and defective high-density lipoproteins-mediated cholesterol efflux, tissue necrosis and cytokine production after myocardial infarction, or metabolic abnormalities associated with diabetes, contribute to atherogenesis and athero-thrombosis. This suggests that in addition to traditional approaches of low-density lipoproteins lowering and anti-platelet drugs, therapies directed at abnormal haematopoiesis, including anti-inflammatory agents, drugs that suppress myelopoiesis, and excessive platelet production, rHDL infusions and anti-obesity and anti-diabetic agents, may help to prevent athero-thrombosis.
authors: Haematopoiesis and Leukocyte Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia Department of Immunology, Monash University, Melbourne, Victoria 3165, Australia andrew.murphy@bakeridi.edu.au.
authors: Andrew J
authors: AJ
authors: Murphy
authors: Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA.
authors: Alan R
authors: AR
authors: Tall
mesh_terms: D050197:Atherosclerosis / Q000503:physiopathology*; D001792:Blood Platelets / Q000502:physiology; D002784:Cholesterol / Q000378:metabolism; D006410:Hematopoiesis / Q000502:physiology*; D006411:Hematopoiesis, Extramedullary / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D007964:Leukocytosis / Q000150:complications / Q000503:physiopathology; D008659:Metabolic Diseases / Q000150:complications / Q000503:physiopathology; D009000:Monocytes / Q000502:physiology; D038042:Myelopoiesis / Q000502:physiology; D009196:Myeloproliferative Disorders / Q000150:complications / Q000503:physiopathology; D009504:Neutrophils / Q000502:physiology; D012307:Risk Factors; D034061:Thrombopoiesis / Q000502:physiology; D013927:Thrombosis / Q000503:physiopathology*
chemical_list: D002784:Cholesterol
keywords: Athero-thrombosis; Atherosclerosis; Haematopoiesis; Monocytes; Neutrophils; Platelets