title: Case Report of an Hepatoid Adenocarcinoma of the Stomach.
abstract: Hepatoid adenocarcinoma (HAC) is a rare but important type of extrahepatic tumor that has a morphologic similarity to hepatocellular carcinoma, with production of α-fetoprotein in high amounts and a poor prognosis. Stomach is one of the organs in which HAC has been most commonly identified. We report a case of an old man with a polypoid mass in the prepyloric region. The microscopical aspects were suggestive for an undifferentiated adenocarcinoma, but the positive immunohistochemical staining for α-fetoprotein, α-1-antitrypsin, α-1-antichymotrypsin, and Hep Par1 were crucial for the final diagnosis of hepatoid adenocarcinoma of the stomach. Because of the poor prognosis for this type of tumor, correct and early-stage diagnosis of HAC is essential and long-term follow-up is required.
authors: U.O. Anatomia Patologica III, Azienda Ospedaliero-Universitaria Pisana, University of Pisa, Pisa, Italy.
authors: Raffaele
authors: R
authors: Gaeta
authors: Clara
authors: C
authors: Ugolini
authors: Maura
authors: M
authors: Castagna
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D022781:Hepatocytes / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D015843:Serpins / Q000378:metabolism; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: C043392:SERPINA1 protein, human; D015843:Serpins; D000515:alpha 1-Antitrypsin; D000509:alpha-Fetoproteins; C072138:antichymotrypsin II