title: Changes in surface electrocardiogram in patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary endarterectomy. Correlations with hemodynamic and echocardiographic improvements after surgery.
abstract: BACKGROUND
  The aim of the present study was to evaluate the changes of electrocardiographic (ECG) markers of right ventricular (RV) hypertrophy/overload in patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing pulmonary endarterectomy (PEA).
  
  
  RESULTS
  We evaluated 99 CTEPH patients who underwent PEA. P wave amplitude in DII, R wave amplitude in V1 and the number of patients with negative T wave in V1-V3 decreased significantly at 1month after surgery with no further change at 1year, in parallel with the rapid improvement in right heart hemodynamics. S wave amplitude in V1, R:S wave ratio in lead V6 and prevalence of SIQIII pattern improved significantly at 1year, in parallel with the progressive reverse remodeling of the right ventricle at echocardiography.
  
  
  CONCLUSIONS
  The study shows that some of the ECG markers of RV hypertrophy/overload better reflect RV hemodynamic overload while others better reflect the pathologic remodeling of the right ventricle.
authors: Division of Cardiology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy. Electronic address: s.ghio@smatteo.pv.it.
authors: Stefano
authors: S
authors: Ghio
authors: Division of Cardiology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
authors: Annalisa
authors: A
authors: Turco
authors: Service of Biometrics & Statistics, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
authors: Catherine
authors: C
authors: Klersy
authors: Division of Cardiology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
authors: Laura
authors: L
authors: Scelsi
authors: Division of Cardiology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
authors: Claudia
authors: C
authors: Raineri
authors: Division of Cardiology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
authors: Valeria
authors: V
authors: Crescio
authors: Division of Cardiology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
authors: Arianna
authors: A
authors: Viscardi
authors: Unit of Cardiac Surgery, Cardiothoracic Transplantation and Pulmonary Hypertension, University of Pavia School of Medicine, Pavia, Italy.
authors: Valentina
authors: V
authors: Grazioli
authors: Unit of Cardiac Surgery, Cardiothoracic Transplantation and Pulmonary Hypertension, University of Pavia School of Medicine, Pavia, Italy.
authors: Antonio
authors: A
authors: Sciortino
authors: Division of Cardiology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
authors: Luigi
authors: L
authors: Oltrona Visconti
authors: Unit of Cardiac Surgery, Cardiothoracic Transplantation and Pulmonary Hypertension, University of Pavia School of Medicine, Pavia, Italy.
authors: Andrea Maria
authors: AM
authors: D'Armini
mesh_terms: D002908:Chronic Disease; D004452:Echocardiography / Q000379:methods; D004562:Electrocardiography / Q000379:methods*; D004691:Endarterectomy; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000000981:diagnostic imaging* / Q000601:surgery*; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000601:surgery*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis / Q000601:surgery
keywords: Electrocardiogram; Pulmonary hypertension