title: Cilia in autophagy and cancer.
abstract: Cancer cells are distinguished from normal cells by increased proliferation and metabolism, loss of polarity control, and the potential to invade other tissues of the body. As hubs of signaling transduction, primary cilia have been linked to diverse developmental and degenerative disorders. Interestingly, loss of cilia has been observed in multiple malignant tumors, suggesting a potential suppressive role of cilia in cancer development. More recently, emerging studies began to unveil the bidirectional interaction of cilia and autophagy, a basic cellular clearance and recycling mechanism to regulate cell homeostasis. Here, we summarize the interplay between cilia and autophagy and discuss the roles of cilia in both autophagy and cancer.
authors: Center for Autophagy Research; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX USA.
authors: Muqing
authors: M
authors: Cao
authors: Center for Autophagy Research; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX USA.
authors: Qing
authors: Q
authors: Zhong
keywords: Autophagy; Cancer; Cell cycle; Cilia; Cilia-related signaling