title: The cut-off value for interleukin 34 as an additional potential inflammatory biomarker for the prediction of the risk of diabetic complications.
abstract: In the present study, we have decided to evaluate whether serum interleukin 34 (IL-34) levels may have diagnostic value in predicting the risk of vascular diabetic complications. The study included 49 patients with type 2 diabetes mellitus (T2DM) and 23 high-risk group. The receiver operating characteristic (ROC) curve analysis has shown that IL-34 has more discriminatory power than C-reactive protein (CRP) for the risk of diabetic complications. The cut-off value for IL-34 was established as 91.2 pg/mL. The gist of our research was identification of IL-34 as an additional potential inflammatory biomarker for the prediction of the risk of vascular diabetic complications.
authors: a Department of Immunobiology and Environment Microbiology , Medical University of Gdańsk , Gdańsk , Poland .
authors: Katarzyna
authors: K
authors: Zorena
authors: b Diabetic Outpatient Clinic in Gdynia , Gdynia , Poland , and.
authors: Olga
authors: O
authors: Jachimowicz-Duda
authors: c Department of Nuclear Medicine , Medical University of Gdańsk , Gdańsk , Poland.
authors: Piotr
authors: P
authors: Wąż
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; C529076:IL34 protein, human; D007378:Interleukins; D002097:C-Reactive Protein
keywords: C-reactive protein; IL-34 cut-off; type 2 diabetes mellitus