title: Substrate-Controlled, One-Pot Synthesis: Access to Chiral Chroman-2-one and Polycyclic Derivatives.
abstract: Based on the appropriate choice of electrophiles, one-pot, multicomponent, enantioselective domino reactions have been realized which contain a five-step sequence and provide highly efficient access to potentially bioactive chroman-2-one derivatives as a single diastereoisomer with excellent enantioselectivities and in high yields. This new strategy could significantly improve the previous protocol by directly starting from commercial 2-hydroxybenzaldehydes rather than preformed lactols, which have to be synthesized in several additional steps.
authors: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, P. R. China.
authors: Xue-Li
authors: XL
authors: Sun
authors: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, P. R. China.
authors: Ying-Han
authors: YH
authors: Chen
authors: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, P. R. China.
authors: Dan-Yang
authors: DY
authors: Zhu
authors: Hubei Key Laboratory for Processing and Application of Catalytic Materials, Huanggang Normal University , Huanggang 438000, P. R. China.
authors: Yan
authors: Y
authors: Zhang
authors: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, P. R. China.
authors: Yan-Kai
authors: YK
authors: Liu
mesh_terms: D002384:Catalysis; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002867:Chromones; D011084:Polycyclic Aromatic Hydrocarbons