title: Cell therapy for retinal disease.
abstract: OBJECTIVE
  The following review will provide an update on stem cell therapy with a focus on completed and ongoing human trials.
  
  
  RESULTS
  Significant progress has brought stem cell therapy from proof-of-concept animal models to human clinical trials. Although in its infancy, valuable safety and efficacy data are starting to emerge from trials looking at cell therapies for age-related macular degeneration, Stargardt's macular dystrophy, retinitis pigmentosa, and ischemic retinopathies.
  
  
  CONCLUSIONS
  Although clinical trials continue to enroll and evaluate stem cell therapy in patients with retinal diseases, preliminary results using both cellular replacement and trophic models have provided initial support for this exciting therapy. Results of these pivotal trials will form a key foundation for moving forward toward the ultimate goal of preventing blinding disease.
authors: Wills Eye Hospital, Philadelphia, Pennsylvania, USA.
authors: David
authors: D
authors: Ehmann
authors: Abtin
authors: A
authors: Shahlaee
authors: Allen C
authors: AC
authors: Ho
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D002986:Clinical Trials as Topic; D006801:Humans; D012164:Retinal Diseases / Q000628:therapy*