title: The Barrier to Autointegration Factor: Interlocking Antiviral Defense with Genome Maintenance.
abstract: Intrinsic defenses targeting foreign DNA are one facet of the cellular armament tasked with protecting host genomic integrity. The DNA binding protein BAF (barrier to autointegration factor) contributes to multiple aspects of genome maintenance and intercepts retrovirus, poxvirus, and herpesvirus genomes during infection. In this gem, we discuss the unique position BAF occupies at the virus-host interface and how both viral and cellular mechanisms may regulate its capacity to act as a pro- or antiviral effector targeting viral DNA.
authors: School of Veterinary Medicine and Biomedical Sciences, University of Nebraska, Lincoln, Nebraska, USA mwiebe@unl.edu.|Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska, USA.
authors: Matthew S
authors: MS
authors: Wiebe
authors: Department of Cancer Immunology and Virology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
authors: Augusta
authors: A
authors: Jamin
mesh_terms: D004279:DNA, Viral / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D015894:Genome, Human; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism*; D016662:Virus Integration
chemical_list: C501959:BANF1 protein, human; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins