title: Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers.
abstract: A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N-isopropylacrylamide) microfibers. The capillary-like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.
authors: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.|Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors: Jung Bok
authors: JB
authors: Lee
authors: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors: Xintong
authors: X
authors: Wang
authors: Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors: Shannon
authors: S
authors: Faley
authors: Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors: Bradly
authors: B
authors: Baer
authors: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors: Daniel A
authors: DA
authors: Balikov
authors: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors: Hak-Joon
authors: HJ
authors: Sung
authors: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.|Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors: Leon M
authors: LM
authors: Bellan
mesh_terms: D000180:Acrylic Resins / Q000494:pharmacology; D020405:Dermis / Q000166:cytology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005780:Gelatin / Q000494:pharmacology*; D006801:Humans; D020100:Hydrogels / Q000494:pharmacology*; D021621:Imaging, Three-Dimensional; D007231:Infant, Newborn; D018613:Microscopy, Confocal; D055806:Microvessels / Q000187:drug effects*; D010477:Perfusion; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D020100:Hydrogels; C052970:poly-N-isopropylacrylamide; D005780:Gelatin
keywords: artificial vasculature; gelatin hydrogel; microfibers; poly(N-isopropylacrylamide); tissue engineering