title: IL-12Rβ2 has a protective role in relapsing-remitting experimental autoimmune encephalomyelitis.
abstract: IL-12Rβ2 is a common receptor subunit of heterodimeric receptors for IL-12 and IL-35, two cytokines that are implicated in immunopathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. We evaluated the role of IL-12Rβ2 in relapsing-remitting EAE (RR-EAE). IL-12Rβ2-deficient SJL/J mice developed markedly more severe clinical EAE, and had greater mortality and more severe relapses compared with wild-type controls. IL-12Rβ2-deficient EAE mice also had more infiltrating mononuclear cells in the CNS, as well as higher T cell proliferative capacity and decreased IFN-γ production at the periphery. These findings demonstrate a protective role of IL-12Rβ2 in RR-EAE.
authors: Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
authors: Chong
authors: C
authors: Xie
authors: Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors: Bogoljub
authors: B
authors: Ciric
authors: Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors: Shuo
authors: S
authors: Yu
authors: Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors: Guang-Xian
authors: GX
authors: Zhang
authors: Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: a.m.rostami@jefferson.edu.
authors: Abdolmohamad
authors: A
authors: Rostami
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002490:Central Nervous System / Q000473:pathology*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000235:genetics / Q000473:pathology* / Q000517:prevention & control*; D005434:Flow Cytometry; D005620:Freund's Adjuvant; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018991:Myelin Proteolipid Protein / Q000633:toxicity; D020556:Neutrophil Infiltration / Q000235:genetics; D010446:Peptide Fragments / Q000633:toxicity; D053707:Receptors, Interleukin-12 / Q000172:deficiency* / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D013997:Time Factors
chemical_list: D016207:Cytokines; D018991:Myelin Proteolipid Protein; D010446:Peptide Fragments; D053707:Receptors, Interleukin-12; C435023:myelin proteolipid protein (139-151); D005620:Freund's Adjuvant
keywords: Experimental autoimmune encephalomyelitis (EAE); IL-12; IL-12Rβ2; IL-35; Relapse