title: Damage to Fronto-Parietal Networks Impairs Motor Imagery Ability after Stroke: A Voxel-Based Lesion Symptom Mapping Study.
abstract: BACKGROUND
  Mental practice with motor imagery has been shown to promote motor skill acquisition in healthy subjects and patients. Although lesions of the common motor imagery and motor execution neural network are expected to impair motor imagery ability, functional equivalence appears to be at least partially preserved in stroke patients.
  
  
  OBJECTIVE
  To identify brain regions that are mandatory for preserved motor imagery ability after stroke.
  
  
  METHODS
  Thirty-seven patients with hemiplegia after a first time stroke participated. Motor imagery ability was measured using a Motor Imagery questionnaire and temporal congruence test. A voxelwise lesion symptom mapping approach was used to identify neural correlates of motor imagery in this cohort within the first year post-stroke.
  
  
  RESULTS
  Poor motor imagery vividness was associated with lesions in the left putamen, left ventral premotor cortex and long association fibers linking parieto-occipital regions with the dorsolateral premotor and prefrontal areas. Poor temporal congruence was otherwise linked to lesions in the more rostrally located white matter of the superior corona radiata.
  
  
  CONCLUSIONS
  This voxel-based lesion symptom mapping study confirms the association between white matter tract lesions and impaired motor imagery ability, thus emphasizing the importance of an intact fronto-parietal network for motor imagery. Our results further highlight the crucial role of the basal ganglia and premotor cortex when performing motor imagery tasks.
authors: Department of Physical and Rehabilitation Medicine, Ghent University Hospital Ghent, Belgium.
authors: Kristine M
authors: KM
authors: Oostra
authors: Department of Rehabilitation Sciences and Physiotherapy, Ghent University Ghent, Belgium.
authors: Anke
authors: A
authors: Van Bladel
authors: Department of Physical and Rehabilitation Medicine, Ghent University Hospital Ghent, Belgium.
authors: Ann C L
authors: AC
authors: Vanhoonacker
authors: Department of Experimental Psychology, Ghent University Ghent, Belgium.
authors: Guy
authors: G
authors: Vingerhoets
keywords: basal ganglia; lesion symptom mapping; motor imagery; stroke; white matter