title: Magnetic resonance imaging-based measures of atlas position: Relationship to canine atlantooccipital overlapping, syringomyelia and clinical signs.
abstract: Canine atlantooccipital overlapping (AOO) is characterized by a decreased distance between the dorsal arch of the atlas and the supraoccipital bone. Current diagnostic criteria for this condition are subjective and clinician-dependent; objective criteria are needed to allow a reliable and reproducible diagnosis in clinical and research settings and assess clinical significance. We propose four standardized MRI-based measurements to objectively assess the proximity of the atlas to the foramen magnum. Inclusion criteria for dogs in this study were bodyweight <15 kg, age >5 months, and availability of a complete MRI study performed with the craniocervical junction in extension. Exclusion criteria were space-occupying lesions and poor image quality (i.e. unclear bony margins). Measurements also included blinded determinations of skull type, presence of craniocervical junction anomalies and presence and severity of syringomyelia. Clinical status at the time of imaging was noted. Measurements were obtained in 271 dogs; these were reproducible and reliable. Findings varied by skull type: dolichocephalic dogs had smaller foramen magnum, whereas brachycephalic dogs had more cranially and dorsally positioned atlas bodies in comparison to the other skull types. Measurements also increased with increases in bodyweight. This study demonstrated a close association between AOO, syringomyelia and clinical signs. Toy and small breed dogs (including Cavalier King Charles spaniels) showed higher than previously reported prevalence of AOO; its occurrence was also associated with lower bodyweights within the study population of <15 kg toy/small breed dogs.
authors: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. Electronic address: sc224@cornell.edu.
authors: S
authors: S
authors: Cerda-Gonzalez
authors: College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors: K F
authors: KF
authors: Bibi
authors: College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors: A T
authors: AT
authors: Gifford
authors: Statistical Consulting Unit, College of Human Ecology, Cornell University, Ithaca, NY 14853, USA.
authors: E L
authors: EL
authors: Mudrak
authors: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors: P V
authors: PV
authors: Scrivani
mesh_terms: D000818:Animals; D001269:Atlanto-Occipital Joint / Q000000981:diagnostic imaging / Q000473:pathology; D001270:Cervical Atlas / Q000000981:diagnostic imaging / Q000473:pathology; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D004285:Dogs; D005260:Female; D005539:Foramen Magnum / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D013595:Syringomyelia / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*
keywords: Brachycephalic; Cavalier; Cervicomedullary; Craniocervical; Neuropathic pain