title: Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer.
abstract: This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann-Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson's correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (p > 0.05). Immunoexpression of p53 was higher in SCC than in AC (p < 0.001), while p21 expression was more observed in AC when compared to SCC group (p = 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression (r = -0.30, p = 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.
authors: Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, CEP 59056-000, Brazil. marialu.diniz@gmail.com.
authors: Maria Luiza Diniz de Sousa
authors: ML
authors: Lopes
authors: Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, CEP 59056-000, Brazil.
authors: Denise Hélen Imaculada Pereira
authors: DH
authors: de Oliveira
authors: State University of Paraíba, Araruna, PB, Brazil.
authors: Dmitry José de Santana
authors: DJ
authors: Sarmento
authors: Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, CEP 59056-000, Brazil.
authors: Lélia Maria Guedes
authors: LM
authors: Queiroz
authors: Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, CEP 59056-000, Brazil.
authors: Márcia Cristina da Costa
authors: MC
authors: Miguel
authors: Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, CEP 59056-000, Brazil.
authors: Éricka Janine Dantas
authors: ÉJ
authors: da Silveira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D063646:Carcinogenesis / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D018797:Cell Cycle Proteins / Q000378:metabolism; D002613:Cheilitis / Q000378:metabolism* / Q000473:pathology; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008046:Lip / Q000473:pathology; D008048:Lip Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051718:MutS Homolog 2 Protein / Q000378:metabolism*; D060787:Neoplasm Grading; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C493956:CDKN1A protein, human; D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein
keywords: Actinic cheilitis; Lip carcinogenesis; Oral cancer; Squamous cell carcinoma