title: Practical Direct α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis.
abstract: Direct arylation of cyclopentanones has been a long-standing challenge because of competitive self-aldol condensation and multiple arylations. Reported herein is a direct mono-α-C-H arylation of cyclopentanones with aryl bromides which is enabled by palladium/amine cooperative catalysis. This method is scalable and chemoselective with broad functional-group tolerance. Application to controlled sequential arylation of cyclopentanones has been also demonstrated.
authors: Department of Chemistry, University of Texas at Austin, 100 East 24th street, Austin, TX, 78712, USA.
authors: Yan
authors: Y
authors: Xu
authors: Department of Chemistry, University of Science and Technology of China (USTC), Hefei, Anhui, 230026, China.
authors: Tianshun
authors: T
authors: Su
authors: Department of Chemistry, University of Texas at Austin, 100 East 24th street, Austin, TX, 78712, USA.
authors: Zhongxing
authors: Z
authors: Huang
authors: Department of Chemistry, University of Texas at Austin, 100 East 24th street, Austin, TX, 78712, USA. gbdong@cm.utexas.edu.
authors: Guangbin
authors: G
authors: Dong
keywords: arylation; homogeneous catalysis; ketones; palladium; synthetic methods