title: Distribution of 28 kDa Calbindin-Immunopositive Neurons in the Cat Spinal Cord.
abstract: The distribution of vitamin D-dependent calcium-binding protein (28 kDa calbindin) was investigated in cat lumbar and sacral spinal cord segments (L1-S3). We observed specific multi-dimensional distributions over the spinal segments for small immunopositive cells in Rexed laminae II-III and medium-to-large cells of varying morphology in lamina I and laminae V-VIII. The small neurons in laminae II-III were clustered into the columns along the dorsal horn curvature. The medium-to-large cells were grouped into four assemblages that were located in (1) the most lateral region of lamina VII at the L1-L4 level; (2) the laminae IV-V boundary at the L5-L7 level; (3) the lamina VII dorsal border at the L5-L7 level; and (4) the lamina VIII at the L5-S3 level. The data obtained suggest that the morphological and physiological heterogeneity of calbindin immunolabeling cells formed morpho-functional clusters over the gray matter. A significant portion of the lumbosacral enlargement had immunopositive neurons within all Rexed laminae, suggesting an important functional role within and among the spinal networks that control hindlimb movements.
authors: Laboratory of Neuromorphology, Pavlov Institute of Physiology RASSaint-Petersburg, Russia; Laboratory of Neuroprosthetics, Institute of Translational Biomedicine, State UniversitySaint-Petersburg, Russia.
authors: Natalia
authors: N
authors: Merkulyeva
authors: Laboratory of Neuromorphology, Pavlov Institute of Physiology RAS Saint-Petersburg, Russia.
authors: Aleksandr
authors: A
authors: Veshchitskii
authors: Laboratory of Neuromorphology, Pavlov Institute of Physiology RAS Saint-Petersburg, Russia.
authors: Felix
authors: F
authors: Makarov
authors: Laboratory of Motor Physiology, Pavlov Institute of Physiology RAS Saint-Petersburg, Russia.
authors: Yury
authors: Y
authors: Gerasimenko
authors: Laboratory of Neuroprosthetics, Institute of Translational Biomedicine, State UniversitySaint-Petersburg, Russia; Laboratory of Motor Physiology, Pavlov Institute of Physiology RASSaint-Petersburg, Russia; Laboratory of Neurophysiology and Experimental Neurorehabilitation, Children's Surgery and Orthopedic Clinic, Department of Non-pulmonary Tuberculosis, Research Institute of PhthysiopulmonologySaint-Petersburg, Russia.
authors: Pavel
authors: P
authors: Musienko
keywords: Ca2+-binding proteins; calbindin-28 kDa; gray matter; interneurons; spinal cord