title: TNFα-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38α MAPK Pathway.
abstract: Smac mimetics (SMs), a class of drugs that can promote tumor cell death, represent a potential therapeutic strategy for the treatment of cancer. In this issue of Cancer Cell, Lalaoui et al. (2016) report that SM efficacy can be potently increased by inhibition of the p38α MAPK/MK2 signaling pathway.
authors: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors: Nomeda
authors: N
authors: Girnius
authors: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA; Howard Hughes Medical Institute. Electronic address: roger.davis@umassmed.edu.
authors: Roger J
authors: RJ
authors: Davis
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology*; D007938:Leukemia / Q000188:drug therapy*; D024101:Mitochondrial Proteins / Q000502:physiology*; D018716:Molecular Mimicry; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D047908:Intracellular Signaling Peptides and Proteins; D024101:Mitochondrial Proteins; D017346:Protein Serine-Threonine Kinases; D048051:p38 Mitogen-Activated Protein Kinases