title: The T helper type 17/regulatory T cell paradigm in pregnancy.
abstract: T helper type 17 (Th17) and regulatory T (Treg) cells are active players in the establishment of tolerance and defence. These attributes of the immune system enmesh to guarantee the right level of protection. The healthy immune system, on the one hand, recognizes and eliminates dangerous non-self pathogens and, on the other hand, protects the healthy self. However, there are circumstances where this fine balance is disrupted. In fact, in situations such as in pregnancy, the foreign fetal antigens challenge the maternal immune system and Treg cells will dominate Th17 cells to guarantee fetal survival. In other situations such as autoimmunity, where the Th17 responses are often overwhelming, the immune system shifts towards an inflammatory profile and attacks the healthy tissue from the self. Interestingly, autoimmune patients have meliorating symptoms during pregnancy. This connects with the antagonist role of Th17 and Treg cells, and their specific profiles during these two immune challenging situations. In this review, we put into perspective the Th17/Treg ratio during pregnancy and autoimmunity, as well as in pregnant women with autoimmune conditions. We further review existing systems biology approaches that study specific mechanisms of these immune cells using mathematical modelling and we point out possible future directions of investigation. Understanding what maintains or disrupts the balance between these two opponent yet reciprocal cells in healthy physiological settings, sheds light into the development of innovative pharmacological approaches to fight pregnancy loss and autoimmunity.
authors: Medical Faculty, Institute for Experimental Internal Medicine, Otto-von-Guericke University, Magdeburg, Germany.
authors: Ana Sofia
authors: AS
authors: Figueiredo
authors: Medical Faculty, Institute for Experimental Obstetrics and Gynecology, Otto-von-Guericke University, Magdeburg, Germany.
authors: Anne
authors: A
authors: Schumacher
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology; D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology; D015551:Autoimmunity; D005260:Female; D006801:Humans; D008962:Models, Theoretical; D011225:Pre-Eclampsia / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D011248:Pregnancy Complications / Q000209:etiology; D047928:Premature Birth / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*
keywords: T helper type 17/regulatory T cell ratio; autoimmunity; defence; mathematical modelling; pregnancy; systems biology; tolerance