title: Low expression of long non-coding RNA-LET can indicate metastasis and a poor prognosis: a meta-analysis.
abstract: BACKGROUND
  Recent studies have reported that the lncRNA-LET was down-regulated in several cancers.The current meta-analysis aims to determine whether lncRNA-LET can be used as a potential biomarker for metastasis and prognosis.
  
  
  METHODS
  We collected all relevant papers by searching multiple electronic databases(Pubmed,EMBASE,Google Scholar,CNKI,Wanfang database) and explored the association between the expression levels of lncRNA-LETand lymph node metastasis (LNM),distant metastasis (DM) and overall survival (OS).
  
  
  RESULTS
  A total of 383 patients from four studies were finally included.The meta-analysis results showed that LNM occurred more frequently in patients with low lncRNA-LET expression group than in patients with high lncRNA-LET expression group(OR=4.56,95%CI:2.92-7.12,p<0.00001),and a similar result was observed between lncRNA-LET expression and DM,the OR was 4.77(95%CI:2.29-9.94, p<0.0001).Additionally,we found that patient with low lncRNA-LET expression had a poorer OS than those high lncRNA-LET expression (HR=2.39,95 %CI:1.57-3.21,p = 0.000).
  
  
  CONCLUSIONS
  LncRNA-LETmay serve as a common molecular marker for metastasis and prognosis in human cancers.
authors: Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China - zhupeiqian@163.com.
authors: Fangteng
authors: F
authors: Liu
authors: Yangxi
authors: Y
authors: Ou
authors: Quan S
authors: QS
authors: Lin
authors: Cheng
authors: C
authors: Qiu
authors: Hong L
authors: HL
authors: Luo
authors: Pei Q
authors: PQ
authors: Zhu