title: Serum angiogenic profile in abnormal placentation.
abstract: OBJECTIVE
  To evaluate the circulating soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF) and vascular endothelial growth factor (VEGF) levels in women with abnormal placentation and to compare the data with the results of women with normal pregnancy.
  
  
  METHODS
  Serum biomarkers of angiogenesis and maternal and perinatal characteristics of 68 pregnant women, all in the third trimester, who were diagnosed to have vaginal bleeding due to complete placenta previa with and without concomitant placenta accreta, increta and percreta as the study group and 30 pregnant women without any placentation abnormality who eventually delivered at  ≥37 weeks of gestational age as the control group were evaluated.
  
  
  RESULTS
  There was no statistical difference in the maternal serum values of sFlt1, PlGF, sFlt1/PlGF ratio and VEGF in groups with placental abnormality as compared to controls. Not even a single case of preeclampsia and intrauterine fetal growth restriction was encountered in the study group.
  
  
  CONCLUSIONS
  We demonstrated that regardless of the localization and the degree of the myometrial invasion of the placenta in the uterus, the circulatory biomarkers of angiogenesis and vascularization were comparable.
authors: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors: Ebru
authors: E
authors: Biberoglu
authors: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors: Ayse
authors: A
authors: Kirbas
authors: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors: Korkut
authors: K
authors: Daglar
authors: b Department of Obstetrics and Gynecology , Gazi University Medical School , Ankara , Turkey .
authors: Kutay
authors: K
authors: Biberoglu
authors: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors: Hakan
authors: H
authors: Timur
authors: c Department of Biochemistry , Gazi University Medical School , Ankara , Turkey , and.
authors: Canan
authors: C
authors: Demirtas
authors: d Department of Biostatistics , Hacettepe University Medical School , Ankara , Turkey.
authors: Erdem
authors: E
authors: Karabulut
authors: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors: Nuri
authors: N
authors: Danisman
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D010921:Placenta Accreta / Q000378:metabolism*; D000072483:Placenta Growth Factor / Q000097:blood*; D010923:Placenta Previa / Q000097:blood*; D011247:Pregnancy; D011505:Protein-Tyrosine Kinases / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor; D011505:Protein-Tyrosine Kinases
keywords: Angiogenesis; abnormally invasive placenta; placenta previa; placental growth factor; soluble Fms-like tyrosine kinase 1; vascular endothelial growth factor