title: Alkane biohydroxylation: Interests, constraints and future developments.
abstract: Alkanes constitute one of the vastest reserves of raw materials for the production of fine chemicals. This paper focuses on recent advances in alkane biohydroxylation, i.e. the bioactivation of alkanes into their corresponding alcohols. Enzyme and whole-cell biocatalysts have been reviewed. Process considerations to implement such biocatalysts in bioreactors at large scale by coupling the bioconversion with cofactor regeneration and product removal are also discussed.
authors: IEM (European Institute of Membranes), UMR 5635 (CNRS-ENSCM-Montpellier University), Place E. Bataillon, F-34095 Montpellier, France. Electronic address: Laurence.Soussan@enscm.fr.
authors: Laurence
authors: L
authors: Soussan
authors: IEM (European Institute of Membranes), UMR 5635 (CNRS-ENSCM-Montpellier University), Place E. Bataillon, F-34095 Montpellier, France.
authors: Nakry
authors: N
authors: Pen
authors: IEM (European Institute of Membranes), UMR 5635 (CNRS-ENSCM-Montpellier University), Place E. Bataillon, F-34095 Montpellier, France.
authors: Marie-Pierre
authors: MP
authors: Belleville
authors: IEM (European Institute of Membranes), UMR 5635 (CNRS-ENSCM-Montpellier University), Place E. Bataillon, F-34095 Montpellier, France.
authors: José Sanchez
authors: JS
authors: Marcano
authors: IEM (European Institute of Membranes), UMR 5635 (CNRS-ENSCM-Montpellier University), Place E. Bataillon, F-34095 Montpellier, France.
authors: Delphine
authors: D
authors: Paolucci-Jeanjean
mesh_terms: D000438:Alcohols / Q000737:chemistry / Q000378:metabolism; D000473:Alkanes / Q000737:chemistry / Q000378:metabolism; D055162:Biocatalysis; D019149:Bioreactors; D001709:Biotechnology / Q000379:methods / Q000639:trends; D006900:Hydroxylation
chemical_list: D000438:Alcohols; D000473:Alkanes
keywords: Alcohol removal; Alkanes; Biocatalysts; Biohydroxylation; Bioreactors; Cofactor regeneration