title: Neural correlates of dystonic tremor: a multimodal study of voice tremor in spasmodic dysphonia.
abstract: Tremor, affecting a dystonic body part, is a frequent feature of adult-onset dystonia. However, our understanding of dystonic tremor pathophysiology remains ambiguous as its interplay with the main co-occurring disorder, dystonia, is largely unknown. We used a combination of functional MRI, voxel-based morphometry and diffusion-weighted imaging to investigate similar and distinct patterns of brain functional and structural alterations in patients with dystonic tremor of voice (DTv) and isolated spasmodic dysphonia (SD). We found that, compared to controls, SD patients with and without DTv showed similarly increased activation in the sensorimotor cortex, inferior frontal (IFG) and superior temporal gyri, putamen and ventral thalamus, as well as deficient activation in the inferior parietal cortex and middle frontal gyrus (MFG). Common structural alterations were observed in the IFG and putamen, which were further coupled with functional abnormalities in both patient groups. Abnormal activation in left putamen was correlated with SD onset; SD/DTv onset was associated with right putaminal volumetric changes. DTv severity established a significant relationship with abnormal volume of the left IFG. Direct patient group comparisons showed that SD/DTv patients had additional abnormalities in MFG and cerebellar function and white matter integrity in the posterior limb of the internal capsule. Our findings suggest that dystonia and dystonic tremor, at least in the case of SD and SD/DTv, are heterogeneous disorders at different ends of the same pathophysiological spectrum, with each disorder carrying a characteristic neural signature, which may potentially help development of differential markers for these two conditions.
authors: Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1137, NY, 10029, USA.
authors: Diana N
authors: DN
authors: Kirke
authors: Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1137, NY, 10029, USA.
authors: Giovanni
authors: G
authors: Battistella
authors: Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1137, NY, 10029, USA.
authors: Veena
authors: V
authors: Kumar
authors: Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1137, NY, 10029, USA.
authors: Estee
authors: E
authors: Rubien-Thomas
authors: Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1137, NY, 10029, USA.
authors: Melissa
authors: M
authors: Choy
authors: School of Health and Rehabilitation Sciences, Speech Pathology, University of Queensland, Brisbane, QLD, Australia.
authors: Anna
authors: A
authors: Rumbach
authors: Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1137, NY, 10029, USA. kristina.simonyan@mssm.edu.|Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, NY, USA. kristina.simonyan@mssm.edu.
authors: Kristina
authors: K
authors: Simonyan
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping; D055154:Dysphonia / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D020821:Dystonic Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging
keywords: Dystonic tremor; Laryngeal dystonia; Tbss; VBM; fMRI