title: Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs).
abstract: Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides.
authors: Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. yaohouzong@163.com.
authors: Houzong
authors: H
authors: Yao
authors: Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. jiangfeng@nbu.edu.cn.|Faculty of Materials Science and Chemical Engineering, the State Key Laboratory Base of Novel Functional Materials and Preparation Science, Ningbo University, Ningbo 315211, Zhejiang, China. jiangfeng@nbu.edu.cn.
authors: Feng
authors: F
authors: Jiang
authors: Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. aipinglu@hkbu.edu.hk.
authors: Aiping
authors: A
authors: Lu
authors: Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. zhangge@hkbu.edu.hk.
authors: Ge
authors: G
authors: Zhang
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D015195:Drug Design; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry*
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D018796:Immunoconjugates
keywords: antibody-drug conjugates (ADCs); drugs; linkers; monoclonal antibodies (mAbs); targeted therapy