title: Same sibling marrow following cord allogeneic transplantation as therapy for second relapse acute promyelocytic leukemia in a pediatric patient.
abstract: Optimal therapy for relapsed APL in pediatric patients is controversial. Allogeneic HSCT is an alternative, with event-free survival of 70-75%. We report a pediatric patient with APL who relapsed 28 months after CBT from her sibling and then was treated with BMT from the same donor. Bone marrow was selected for higher cell dose, donor availability, and partial donor chimerism. Persistent molecular remission was achieved, currently at 65 months after BMT. This case suggests the potential role of GVL activity in APL and illustrates the use of different cell sources from the same donor in allogeneic transplantation for pediatric patients.
authors: Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.|Division of Hematology/Oncology, Mattel Children's Hospital-UCLA Medical Center, Los Angeles, CA, USA.
authors: Satiro N
authors: SN
authors: De Oliveira
authors: Division of Hematology/Oncology, Mattel Children's Hospital-UCLA Medical Center, Los Angeles, CA, USA.
authors: Roy L
authors: RL
authors: Kao
authors: Department of Internal Medicine, Scripps Mercy Hospital, San Diego, CA, USA.
authors: Andrew
authors: A
authors: Pham
authors: Division of Hematology/Oncology, Mattel Children's Hospital-UCLA Medical Center, Los Angeles, CA, USA.
authors: LaMarr Taylor
authors: LT
authors: Smith
authors: Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.|Division of Hematology/Oncology, Mattel Children's Hospital-UCLA Medical Center, Los Angeles, CA, USA.
authors: Pamela
authors: P
authors: Kempert
authors: Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.|Division of Hematology/Oncology, Mattel Children's Hospital-UCLA Medical Center, Los Angeles, CA, USA.
authors: Theodore B
authors: TB
authors: Moore
mesh_terms: D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D005260:Female; D006086:Graft vs Host Disease; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000628:therapy*; D008297:Male; D012008:Recurrence; D012074:Remission Induction; D035781:Siblings; D013997:Time Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D006680:HLA Antigens
keywords: acute promyelocytic leukemia; bone marrow transplant; graft-versus-leukemia; umbilical cord blood