title: Resistance patterns of multidrug resistant Acinetobacter baumannii in an ICU of a tertiary care hospital, Malaysia.
abstract: Antimicrobial resistance is a major health problem worldwide in hospitals. The main contributing factors are exposures to broad-spectrum antimicrobials and cross-infections. Understanding the extent and type of antimicrobial use in tertiary care hospitals will aid in developing national antimicrobial stewardship priorities.
  
  
  METHODS
  In this study, we have analyzed the antimicrobial agents' usage for acquisition of multidrug resistant using retrospective, cross-sectional, single-centre study in a multidisciplinary ICU at tertiary care hospital.
  
  
  RESULTS
  Acinetobacter baumannii (ACB) was isolated in various specimens from 662 patients. From these, 136 patients who were diagnosed with Ventilator-associated pneumonia (VAP) caused by ACB were included into the study. In our study, MDR strain accounts for 51% of all VAP cases caused by ACB. The development of ACB VAP were 10.5 + 6.4 days for MDR strains compared to susceptible organism (7.8 + 4.5 days) and had significantly longer ICU stay.
  
  
  CONCLUSIONS
  The study concludes that prudent use of antimicrobial agents is important to reduce acquisition of MDR ACB.
authors: Sivakami Janahiraman, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Wilayah Persekutuan Kuala Lumpur, Malaysia.
authors: Sivakami
authors: S
authors: Janahiraman
authors: Muhammad Nazri Aziz, LABLINK (M) SDN. BHD. Bangunan LABLINK, 14 (129) Jalan Pahang Barat, Off Jalan Pahang, 53000 Kuala Lumpur. Malaysia.
authors: Muhammad Nazri
authors: MN
authors: Aziz
authors: Fan Kee Hoo, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
authors: Fan Kee
authors: FK
authors: Hoo
authors: Hon Shen P'ng, Department of Medicine, Hospital Sultanah Nora Ismail, Batu Pahat, Johor, Malaysia.
authors: Hon Shen
authors: HS
authors: P'ng
authors: Yang Liang Boo, Department of Medicine, Hospital Enche' Besar Hajjah Khalsom, Kluang Johor, Malaysia.
authors: Yang Liang
authors: YL
authors: Boo
authors: Vasudevan Ramachandran, Malaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang, Malaysia.
authors: Vasudevan
authors: V
authors: Ramachandran
authors: Ahmad Fuad Shamsuddin, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Wilayah Persekutuan Kuala Lumpur, Malaysia.
authors: Ahmad Fuad
authors: AF
authors: Shamsuddin
keywords: Acinetobacter baumannii; Acinetobacter baumannii: ACB; Clinical and Laboratory Standards Institute: (CLSI); Culture and sensitivity: C&S; Drug Resistance; Intensive Care Units; Malaysia; Ventilator-associated pneumonia; intensive care units: ICU; multidrug-resistant: MDR; ventilator-associated pneumonia: VAP