title: Lipid Changes in Virologically Suppressed HIV-Infected Patients Switching from any Antiretroviral Therapy to the Emtricitabine/Rilpivirine/Tenofovir Single Tablet: GeSida Study 8114.
abstract: We carried out a retrospective, multicenter study of a cohort of 298 asymptomatic HIV-infected patients who switched from a regimen based on 2 nucleoside reverse transcriptase inhibitors + protease inhibitor (PI)/nonnucleoside reverse transcriptase inhibitor or ritonavir-boosted PI monotherapy to emtricitabine/rilpivirine/tenofovir disoproxil fumarate (FTC/RPV/TDF) to analyze lipid changes. At 24 weeks, 284 (95.3%) patients were still taking the same regimen, maintaining similar CD4 counts as at baseline (651 versus 672 cells/mm(3), P = .08), and 98.9% of them with an undetectable viral load. Eight of the other 14 patients were lost to follow up and 6 (2.0%) ceased the new regimen: 3 due to adverse effects, 2 due to virologic failure, and 1 due to abandonment. The mean levels of fasting total cholesterol (TC), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), and triglycerides fell at 12 and 24 weeks, with no changes detected in the TC to HDL-C ratio.
authors: Hospital Virgen de la Victoria, Málaga, Spain Instituto de Investigación Biomédica de Málaga (IBIMA), Spain rosariopalaci@gmail.com.
authors: Rosario
authors: R
authors: Palacios
authors: Hospital Carlos Haya, Málaga, Spain.
authors: Marisa
authors: M
authors: Mayorga
authors: Hospital Virgen de la Victoria, Málaga, Spain Instituto de Investigación Biomédica de Málaga (IBIMA), Spain.
authors: Isabel A
authors: IA
authors: Pérez-Hernández
authors: Hospital Costa del Sol, Marbella, Spain.
authors: Antonio
authors: A
authors: Rivero
authors: Hospital Reina Sofía, Córdoba, Spain.
authors: Alfonso Del
authors: AD
authors: Arco
authors: Hospital de Valme, Sevilla, Spain.
authors: Fernando
authors: F
authors: Lozano
authors: Hospital Virgen de la Victoria, Málaga, Spain Instituto de Investigación Biomédica de Málaga (IBIMA), Spain.
authors: Jesús
authors: J
authors: Santos
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood*; D057915:Drug Substitution / Q000379:methods / Q000706:statistics & numerical data; D000068678:Emtricitabine, Rilpivirine, Tenofovir Drug Combination / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013607:Tablets; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; D000068678:Emtricitabine, Rilpivirine, Tenofovir Drug Combination; D013607:Tablets; D002784:Cholesterol
keywords: HIV; lipids; switching study