title: Polymorphisms in NF-κB pathway genes & their association with risk of lung cancer in the Chinese population.
abstract: OBJECTIVE
  To investigate the association of NFKB1 -94 ins/del ATTG, NFKBIA -826C>T and NFKBIA -881A>G polymorphisms with risk of lung cancer in a Chinese population.
  
  
  METHODS
  Genotyping of the polymorphisms were performed on 1,436 subjects (718 cases and 718 controls) by using PCR-RFLP technique, followed by DNA sequencing.
  
  
  RESULTS
  We found a significant risk reduction associated with heterozygous ins/del (OR=0.705, 95% CI=0.566-0.878, P=0.002) and variant del/del (OR=0.342, 95% CI=0.221-0.528, P<0.001) genotypes of the NFKB1 polymorphism. In contrast, the heterozygous and variantgenotypes of theNFKBIA polymorphisms showed association with increased lung cancer risk (NFKBIA -826 CT,OR=1.256, 95%CI=1.004-1.572, P=0.046; TT,OR=1.773, 95% CI=1.131-2.778, P=0.013; NFKBIA -881 AG,OR=1.277, 95% CI=1.023-1.599, P=0.031; GG,OR=1.801, 95% CI=1.169-2.775, P=0.008). Several genotypic combinations of the three polymorphisms also showed significant association with lung cancer risk. The risk association of NFKB1 polymorphism remained significant when analyses were done according to gender and smoking status (P<0.05). The significance of NFKBIA risk association was not observed when gender-specific analyses were made (P>0.05), while only NFKBIA -881 GG genotype showed significant risk association among smokers when analyzed according to smoking status (P=0.032).
  
  
  CONCLUSIONS
  Polymorphisms in NFKB1 and NFKBIAgenes were associated with risk of lung cancer.
authors: Jing-Wei Zhang, MD. Department of Respiratory, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
authors: Jing-Wei
authors: JW
authors: Zhang
authors: Qiu-Sheng Chen, MD. Department of Respiratory, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
authors: Qiu-Sheng
authors: QS
authors: Chen
authors: Jian-Xia Zhai, MD. Department of Respiratory, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
authors: Jian-Xia
authors: JX
authors: Zhai
authors: Peng-Ju Lv, MD. Translational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
authors: Peng-Ju
authors: PJ
authors: Lv
authors: Xiao-Yan Sun, MD. Translational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
authors: Xiao-Yan
authors: XY
authors: Sun
keywords: Genetic variation; Lung cancer; NF-κB; Polymorphism; Risk