title: [CATALITICAL PROPERTIES OF LIVER MONOAMINE OXIDASE IN THE CHUM SALMON ONCORHYNCHUS KETA].
abstract: The substrate and inhibitory specificity of mitochondrial monoamine oxidase (MAO) in the liver of males of the summer form of the chum salmon Oncorhynchus keta was studied. As to the spectrum of deaminated substrates, the hepatic MAO of the chum salmon is similar to MAO of most terrestrial mammals, for eight classical MAO substrates similarity in their substrate characteristics were found. Analysis of the antimonoamine oxidase activity of two derivaties of 2-propinilamine, five derivatives of acridine as well as of pyronine G revealed significant qualitative and quantitative differences as compared to the hepatic enzyme of tuna and whitefish. The compounds tested manifested themselves as irreversible inhibitors of chum salmon's hepatic MAO possessing various efficacy, but lacking the selectivity of action as dependent on the deaminated substrate. The obtained data on the substrate and inhibitory analysis provide an indirect evidence for the presence of a single molecular form of MAO in the chum salmon liver.
authors: I N
authors: IN
authors: Basova
authors: N E
authors: NE
authors: Basova
authors: O V
authors: OV
authors: Yagodina
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D029941:Fish Proteins / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D024101:Mitochondrial Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism*; D010293:Pargyline / Q000031:analogs & derivatives / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D011754:Pyronine / Q000494:pharmacology; D012474:Salmon / Q000378:metabolism*; D012487:Salmonidae / Q000378:metabolism; D013045:Species Specificity; D014413:Tuna / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D029941:Fish Proteins; D024101:Mitochondrial Proteins; D011437:Propylamines; C009054:propargylamine; D010293:Pargyline; D008995:Monoamine Oxidase; D011754:Pyronine