title: Dendrite and Axon Specific Geometrical Transformation in Neurite Development.
abstract: We propose a model of neurite growth to explain the differences in dendrite and axon specific neurite development. The model implements basic molecular kinetics, e.g., building protein synthesis and transport to the growth cone, and includes explicit dependence of the building kinetics on the geometry of the neurite. The basic assumption was that the radius of the neurite decreases with length. We found that the neurite dynamics crucially depended on the relationship between the rate of active transport and the rate of morphological changes. If these rates were in the balance, then the neurite displayed axon specific development with a constant elongation speed. For dendrite specific growth, the maximal length was rapidly saturated by degradation of building protein structures or limited by proximal part expansion reaching the characteristic cell size.
authors: Department of Neurotechnologies, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod Nizhny Novgorod, Russia.
authors: Vasily I
authors: VI
authors: Mironov
authors: Department of Neurotechnologies, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod Nizhny Novgorod, Russia.
authors: Alexey V
authors: AV
authors: Semyanov
authors: Department of Neurotechnologies, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny NovgorodNizhny Novgorod, Russia; Laboratory of Nonlinear Dynamics of Living Systems, Institute of Applied Physics of the Russian Academy of ScienceNizhny Novgorod, Russia.
authors: Victor B
authors: VB
authors: Kazantsev
keywords: active transport; microtubule cytoskeleton; neurite outgrowth; shape specific elongation; tubulin