title: Assessment of collagen versus non collagen coated anterior vaginal mesh in pelvic reconstructive surgery: prospective study.
abstract: OBJECTIVE
  To evaluate the sonologic and clinical outcome of collagen coated (CC) versus non-collagen coated (NC) anterior vaginal mesh (AVM) for pelvic organ prolapse (POP) surgery.
  
  
  METHODS
  The study is a prospective observational study which included 122 patients who had symptomatic POP stage III and IV. AvaultaPlus™ (collagen coated, CC group) was compared to Perigee™ (non collagen coated, NC group). Introital ultrasound morphology, measure of neovascularization by color Doppler and clinical outcomes were assessed. Student t test was used for comparison of pre- and post-operation continuous data (p value of <0.05).
  
  
  RESULTS
  A total of 110 (CC group=50, NC group=60) women completed the study. A woman in the CC group developed ureteral injury. Both groups had comparable morphologic and clinical outcomes however, the onset of changes in mesh thickness and neovascularization occurred earlier in the NC group (1 month) compared to the CC group (6 months to 1 year).
  
  
  CONCLUSIONS
  CC group was comparable to the NC group in terms of erosion rate, ultrasound and clinical assessment. Collagen coating may induce delayed inflammatory response however may also delay tissue integration. The onset of changes in mesh thickness and neovascularization may give us an insight toward utilization of collagen coated mesh for host-tissue integration.
authors: Department of Obstetrics and Gynecology, Keelung Medical Center, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC; Division of Urogynecology, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taoyuan, Taiwan, ROC. Electronic address: 2378@cgmh.org.tw.
authors: Tsia-Shu
authors: TS
authors: Lo
authors: Fellow of the Division of Urogynecology, Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Department of Obstetrics and Gynecology, De La Salle University Medical Center, Dasmariñas Cavite, Philippines.
authors: Eileen Feliz M
authors: EFM
authors: Cortes
authors: Department of Obstetrics and Gynecology, Keelung Medical Center, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC.
authors: Pei-Ying
authors: PY
authors: Wu
authors: Fellow of the Division of Urogynecology, Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Department of Obstetrics and Gynecology, Kuching Specialist Hospital, Sarawak, Malaysia.
authors: Yiap Loong
authors: YL
authors: Tan
authors: Fellow of the Division of Urogynecology, Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Department of Obstetrics & Gynecology, King Abdullah University Hospital, University of Science & Technology, Irbid, Jordan.
authors: Ahlam
authors: A
authors: Al-Kharabsheh
authors: Fellow of the Division of Urogynecology, Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Department of Obstetrics and Gynecology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.
authors: Leng Boi
authors: LB
authors: Pue
mesh_terms: D000368:Aged; D003094:Collagen; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods*; D013526:Surgical Mesh; D014621:Vagina / Q000601:surgery*
chemical_list: D003094:Collagen
keywords: Avaulta; Collagen mesh; Introital ultrasound; Pelvic organ prolapse; Perigee