title: Aberrant expression of hSef and Sprouty4 in endometrial adenocarcinoma.
abstract: Fibroblast growth factor (FGF) 2-mediated signaling of the mitogen-activated protein kinase/RAS/extracellular signal-regulated kinase 1/2 pathway is a critical modulator in angiogenesis and is therefore essential for the pathogenesis of endometrial carcinoma. Human similar expression to FGFs (hSef) and Sprouty4 have each been reported to be negative regulators of FGF signaling. The aim of the present study was to investigate the expression of hSef and Sprouty4 in human endometrial adenocarcinoma. Using immunohistochemistry analysis, the expression of hSef and Sprouty4 was detected in human endometrial adenocarcinomas. Increased hSef expression was found to be present in endometrial adenocarcinomas. In addition, decreased hSef expression was identified in the blood vessels of endometrial adenocarcinoma samples. However, the expression of Sprouty4 was downregulated in human endometrial adenocarcinoma. Aberrant expression of hSef and Sprouty4 are involved in the pathogenesis of human endometrial adenocarcinoma.
authors: Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
authors: Hui
authors: H
authors: Zhang
authors: Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
authors: Qiufen
authors: Q
authors: Guo
authors: Department of Nursing, Shandong Rongjun General Hospital, Jinan, Shandong 250013, P.R. China.
authors: Xia
authors: X
authors: Wang
authors: Department of General Surgery, Shandong Rongjun General Hospital, Jinan, Shandong 250013, P.R. China.
authors: Chong
authors: C
authors: Wang
authors: Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
authors: Xingbo
authors: X
authors: Zhao
authors: Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
authors: Mingjiang
authors: M
authors: Li
keywords: Sprouty4; blood vessel; endometrial adenocarcinoma; fibroblast growth factor 2/mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 signaling; hSef