title: Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary Retinoblastoma.
abstract: Patients with hereditary retinoblastoma have a heightened risk of developing subsequent bone and soft tissue sarcomas, exacerbated by radiation and alkylating chemotherapy. Secondary leiomyosarcomas are rare. A 29-year-old patient with bilateral retinoblastoma history presented with concurrent, independent malignancies found to be Rb-suppressed uterine and Rb-positive bladder leiomyosarcomas. She had undergone both ifosfamide chemotherapy and radiation therapy but demonstrated rare simultaneous primary leiomyosarcomas not previously described in association with ifosfamide. This rare case underlines the protean genetic predisposition to malignancy in this patient population, heightening awareness of lifelong malignancy potential, and the necessity for continuous periodic screening.
authors: Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors: Katherine
authors: K
authors: Moore
authors: Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors: Ossama
authors: O
authors: Tawfik
authors: Department of Hematology/Oncology, Children's Mercy Hospital, Kansas City, MO 64108, USA; School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
authors: Allyson
authors: A
authors: Hays
authors: Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors: Isaac
authors: I
authors: Opole