title: Microwave-Assisted Copper-Catalyzed Oxidative Cyclization of Acrylamides with Non-Activated Ketones.
abstract: An operationally simple and efficient microwave-assisted protocol for the oxidative cyclization of acrylamide derivatives with non-activated ketones to generate 3,3-disubstituted oxindoles is described. The reaction proceeds by a copper-catalyzed tandem radical addition/cyclization strategy and tolerates a series of functional groups with moderate to excellent yields.
authors: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001, Leuven, Belgium.|Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
authors: Yaping
authors: Y
authors: Zhao
authors: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001, Leuven, Belgium. n_sharma023@yahoo.co.in.
authors: Nandini
authors: http://orcid.org/0000-0001-6249-7815
authors: N
authors: Sharma
authors: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001, Leuven, Belgium.
authors: Upendra K
authors: UK
authors: Sharma
authors: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001, Leuven, Belgium.
authors: Zhenghua
authors: Z
authors: Li
authors: Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
authors: Gonghua
authors: G
authors: Song
authors: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001, Leuven, Belgium. erik.vandereycken@chem.kuleuven.be.
authors: Erik V
authors: EV
authors: Van der Eycken
keywords: alkenes; copper; ketones; oxindoles; radical addition