title: Can postpartum maternal urinary iodine be used to estimate iodine nutrition status of newborns?
abstract: I deficiency can lead to detrimental effects, particularly in neonates and young infants. The aim of this study was to explore whether postpartum maternal urinary I can be used to estimate the I status of newborns. In this cross-sectional study conducted in Tehran, lactating mothers and newborns, within 3-5 d postpartum, were randomly selected. Urine samples were collected from each mother and newborn, and a heel-prick blood sample was obtained from all newborns as part of the routine national newborn screening programme. According to the WHO criteria, median urinary I concentration (UIC) 5 mIU/l was considered as I insufficiency. A total of 147 postpartum women and neonates, aged 27·8 (SD 5·3) years and 4·2 (SD 0·6) d, respectively, completed this study. The median UIC was 68·0 (interquartile range (IQR) 39·4-133·5) and 212·5 (IQR 92·3-307·3) µg/l in postpartum mothers and newborns, respectively. The median neonatal TSH was 1·00 (IQR 0·50-1·70) mIU/l. There was no significant difference in the neonatal UIC and TSH of infants whose mothers had deficient and sufficient urinary I. In the multiple linear regression, neonatal UIC value was associated with maternal urinary I (P=0·048) and parity (P=0·039); a significant association was observed between neonatal TSH and infant sex (P=0·038) and birth weight (P=0·049). The findings of our study demonstrate that, despite postpartum mothers being mildly I deficient, I status of their infants was adequate as assessed by UIC and TSH values. It seems factors other than maternal urinary I may influence the I status in newborns.
authors: 1Nutrition and Endocrine Research Center,Research Institute for Endocrine Sciences,Shahid Beheshti University of Medical Sciences,19395-4763,Tehran,Iran.
authors: Pantea
authors: P
authors: Nazeri
authors: 1Nutrition and Endocrine Research Center,Research Institute for Endocrine Sciences,Shahid Beheshti University of Medical Sciences,19395-4763,Tehran,Iran.
authors: Parvin
authors: P
authors: Mirmiran
authors: 2Cellular and Molecular Research Center,Research Institute for Endocrine Sciences,Shahid Beheshti University of Medical Sciences,19395-4763,Tehran,Iran.
authors: Mehdi
authors: M
authors: Hedayati
authors: 3Department of Epidemiology,School of Public Health,Shahid Beheshti University of Medical Sciences,19835-35511,Tehran,Iran.
authors: Yadollah
authors: Y
authors: Mehrabi
authors: 4Endocrine Research Center,Research Institute for Endocrine Sciences,Shahid Beheshti University of Medical Sciences,19395-4763,Tehran,Iran.
authors: Hossein
authors: H
authors: Delshad
authors: 4Endocrine Research Center,Research Institute for Endocrine Sciences,Shahid Beheshti University of Medical Sciences,19395-4763,Tehran,Iran.
authors: Fereidoun
authors: F
authors: Azizi
mesh_terms: D000328:Adult; D001724:Birth Weight; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007455:Iodine / Q000172:deficiency* / Q000652:urine*; D007492:Iran; D016014:Linear Models; D008297:Male; D015997:Neonatal Screening / Q000379:methods*; D009752:Nutritional Status; D049590:Postpartum Period / Q000652:urine*; D012737:Sex Factors; D013972:Thyrotropin / Q000097:blood
chemical_list: D013972:Thyrotropin; D007455:Iodine
keywords: IQR interquartile range; Newborns; Postpartum mothers; TSH thyroid stimulating hormone; Thyroid stimulating hormone; UIC urinary iodine concentration; Urinary iodine