title: The Event-related Potential P300 in Patients with Migraine.
abstract: OBJECTIVE
  Recording of event-related potentials by using oddball paradigm of auditory P300 has yielded conflicting results in migraine. The aim of this study was to demonstrate that migraine patients have reduced P300 amplitude and prolonged P300 latency, suggesting alterations of the cognitive-evaluative component.
  
  
  METHODS
  We recruited 29 migraine patients (24 females; median age 40 years) and 29 healthy age- and gender-matched participants. Participants were subjected to the same testing procedures of auditory P300 by discrimination the target auditory stimulus from the frequent stimulus, and analyzing P300 target/frequent stimulus amplitudes, and P300 target/frequent stimulus latencies.
  
  
  RESULTS
  Patients with migraine don't have prolonged P300 target stimulus latency, but have a longer P300 frequent stimulus latency for 17.5ms. Out of 29 participants with migraine 8 had pathological P300 target stimulus amplitude, and 19 had pathological P300 frequent stimulus amplitude.
  
  
  CONCLUSIONS
  People with migraine have altered the P300 which indicates the presence of cognitive dysfunction in these patients and importance of early diagnosis and intervention to preventing any deterioration in cognitive functions.
authors: Clinical Department of Neurology, Split University Hospital Center, Split, Croatia.
authors: Marina
authors: M
authors: Titlic
authors: Clinical Department of Neurology, Split University Hospital Center, Split, Croatia.
authors: Nikolina Ivica
authors: NI
authors: Mise
authors: Clinical Department of Neurology, Split University Hospital Center, Split, Croatia.
authors: Irena
authors: I
authors: Pintaric
authors: Clinical Department of Ophthalmology, Split University Hospital Center, Split, Croatia.
authors: Veljko
authors: V
authors: Rogosic
authors: Private Dermatovenerology Clinic, Split, Croatia.
authors: Lucija
authors: L
authors: Vanjaka-Rogosic
authors: Clinical Department of Neurology, Split University Hospital Center, Split, Croatia.
authors: Mario
authors: M
authors: Mihalj
authors: Clinical Department of Neurology, Split University Hospital Center, Split, Croatia.
authors: Pavao
authors: P
authors: Jurinovic
authors: Clinical Department of Neurology, Split University Hospital Center, Split, Croatia.
authors: Ana Curkovic
authors: AC
authors: Katic
authors: Department of Psychology, Faculty of Philosophy, University of Zagreb, Zagreb, Croatia.
authors: Maja
authors: M
authors: Andjelinovic
keywords: P300; cognition; event-related potentials; migraine disorders