title: Concise Review: Cell Therapies for Stroke and Traumatic Brain Injury: Targeting Microglia.
abstract: We present a model hypothesis of how several types of cell therapies may target microglia as one of the principal cell types contributing to the inflammatory response after brain injury and discuss how imaging of brain inflammation could potentially be applied to develop biomarkers in patients with stroke and TBI enrolled into stem cell clinical trials.
authors: Department of Neurology, UT-Health, Houston, Texas, USA.
authors: Sean I
authors: SI
authors: Savitz
authors: Department of Pediatric Surgery, UT-Health, Houston, Texas, USA.
authors: Charles S
authors: CS
authors: Cox
mesh_terms: D000818:Animals; D015415:Biomarkers; D000070642:Brain Injuries, Traumatic / Q000473:pathology / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000473:pathology; D017628:Microglia / Q000378:metabolism / Q000473:pathology / Q000637:transplantation; D033581:Stem Cell Transplantation; D020521:Stroke / Q000473:pathology / Q000628:therapy*
chemical_list: D015415:Biomarkers
keywords: Brain injuries; Microglia; Stem cells; Stroke