title: Expression of metabotropic glutamate receptor 4 in osteosarcoma.
abstract: Metabotropic glutamate receptor 4 (mGluR4) has been associated with the pathogenesis of osteosarcoma. The aim of this study was to investigate mGluR4 expression and its clinical significance in osteosarcoma patients. mGluR4 expression was investigated using immunohistochemistry (IHC) in 58 osteosarcomas and 32 giant-cell tumors of bone. The correlations between mGluR4 expression and clinicopathological characteristics were analyzed with the Chi-squared test and survival curves were generated using the Kaplan-Meier method. The IHC results demonstrated that 20.69% (12/58) of the osteosarcomas and 43.75% (14/32) of the giant-cell tumors were mGluR4-positive. The statistical analysis revealed that mGluR4 expression was correlated with gender, age, Enneking stage and tumor volume in osteosarcomas (P<0.05). In the multivariate stepwise Cox regression analysis, Enneking stage was found to be statistically signiﬁcantly associated with survival (P<0.05) and the survival analysis demonstrated that the survival probability was significantly higher in patients with higher mGluR4 expression compared with those with lower expression (P<0.05). Therefore, mGluR4 expression may be used to estimate the prognosis of osteosarcoma patients.
authors: Department of Orthopedic Oncology, the First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing 100048, P.R. China.
authors: Shuo
authors: S
authors: Wang
authors: Department of Orthopedic Oncology, the First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing 100048, P.R. China.
authors: Xing
authors: X
authors: Wei
authors: Department of Orthopedic Oncology, the First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing 100048, P.R. China.
authors: Bingyao
authors: B
authors: Chen
authors: Department of Pathology, the First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing 100048, P.R. China.
authors: Min
authors: M
authors: Zhao
authors: Department of Orthopedic Oncology, the First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing 100048, P.R. China.
authors: Guangze
authors: G
authors: Song
authors: Department of Orthopedic Oncology, the First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing 100048, P.R. China.
authors: Zengliang
authors: Z
authors: Zhang
authors: Department of Orthopedic Oncology, the First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing 100048, P.R. China.
authors: Nan
authors: N
authors: Li
keywords: immunohistochemistry; metabotropic glutamate receptor 4; osteosarcoma; prognosis