title: CD4 T-LYMPHOCYTE SUBSETS IN WOMEN WITH INVASIVE CERVICAL CANCER IN KENYA.
abstract: OBJECTIVE
  Invasive cervical cancer (ICC) and HIV are common in sub-Sahara Africa. Both ICC and HIV are immunosuppressive, and are associated with decreased CD4 and CD8 profiles. In a group of women with ICC starting radiotherapy, we determined their CD4 profiles.
  
  
  METHODS
  A cross-sectional study.
  
  
  METHODS
  Kenyatta National Hospital, Nairobi, Kenya, radiotherapy unit.
  
  
  METHODS
  Women with invasive cervical cancer (344) seeking radiotherapy treatment for the first time between January 2000 and March 2003, had blood samples analyzed for CD4 and CD8 cell counts by flow cytometry. Haemoglobin, white cell count, lymphocyte and platelet counts were determined using coulter machine. All patients had received pre- and post HIV counseling.
  
  
  RESULTS
  The mean age was 49+13 years. About 13.1% of the women with ICC were HIV positive. Overall, mean and median CD4 cell count was 829+355 cells/mm and 792 cells/mm3. Among HIV+ patients, mean and median CD4 cell counts were 451+288 cells/mm and 405 cells/mm respectively. The mean CD4 cell count for the HIV+ womenwas 886+329 cells/mm3 with median of 833 cells/mm3, range 147-2065 cells/mm3. Only nine (20%) of the 45 HIV+ women had CD4 cell count of 0-200. HIV+ women had lower CD4 percentage and cell count and higher CD8 percentage and cell count as compared to HIV negative women, p < 0.001. HIV infection was significantly and independently associated with high proportion of women who had CD4 cell count of less than 200 cells/mm3 or less than 350 cells/mm3, p < 0.0001.
  
  
  CONCLUSIONS
  Women with ICC and concurrent HIV infection have decreased CD4 cell subset. These results suggest HIV infection may be associated with more severe CD4 depletion in women with ICC.
authors: Department of Human Anatomy, College of Health Sciences, University of Nairobi, PO Box 19676-00202, Nairobi, Kenya.
authors: P
authors: P
authors: Gichangi
authors: L
authors: L
authors: Gathece
authors: B
authors: B
authors: Estambale
authors: M
authors: M
authors: Temmerman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology*; D006801:Humans; D007630:Kenya; D008875:Middle Aged; D016176:T-Lymphocyte Subsets; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000276:immunology*; D055815:Young Adult