title: Regioselective ortho-trifluoromethylthiolation of 2-arylbenzo[d]thiazole via tandem substrate-assisted C-H iodination and trifluoromethylthiolation.
abstract: A mild and efficient tandem benzo[d]thiazole directed C-H iodination and trifluoromethylthiolation for the synthesis of ortho-trifluoromethylthiolated 2-arylbenzo[d]thiazoles have been developed using AgSCF3 as a coupling partner. The reaction exhibits a diverse array of functional group tolerance giving the desired products in good to excellent yields. Regioselective trifluoromethylthiolation was observed at the less sterically hindered site when the phenyl ring of the substrate possesses a methyl group at its meta position.
authors: Department of Occupational and Environmental Health, School of Public Health, Central South University, 110 Xiang-ya Road, Changsha, Hunan 410078, P. R. China. jiananhu@csu.edu.cn and Department of Obstetrics and Gynecology, Jiangxi Provincial people's Hospital, Nanchang, Jiangxi 330006, P. R. China.
authors: Puying
authors: P
authors: Luo
authors: College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China. dingqiuping@jxnu.edu.cn.
authors: Qiuping
authors: Q
authors: Ding
authors: College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China. dingqiuping@jxnu.edu.cn.
authors: Yuanyuan
authors: Y
authors: Ping
authors: Department of Occupational and Environmental Health, School of Public Health, Central South University, 110 Xiang-ya Road, Changsha, Hunan 410078, P. R. China. jiananhu@csu.edu.cn.
authors: Jianan
authors: J
authors: Hu