title: Facial Scars following Toxic Epidermal Necrolysis: Role of Adnexal Involvement?
abstract: Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse drug reaction leading to extensive sloughing of the skin. Late cutaneous complications such as pigmentation disorders are frequently reported. In this report, we present particular facial cutaneous sequelae with histological analysis after TEN. Two young patients who had survived TEN presented permanent multiple hypopigmented papules on the face affecting their quality of life. Histological analysis revealed areas of scarring, dystrophic microcalcifications and sebaceous hyperplasia. Late cutaneous sequelae are well documented; however, the physiopathological mechanisms leading to different clinical presentations remain unknown. We suggest that the destruction of the hair follicle by necrolysis leads to secondary dermal microcalcifications, scarring and sebaceous hyperplasia. Further studies are needed for a better understanding of these findings.
authors: Referral Center for Autoimmune and Toxic Bullous Diseases, Dermatology Department, Hx00F4;pitaux Universitaires Henri-Mondor, Universitx00E9; Paris-Est Crx00E9;teil, Crx00E9;teil, France.
authors: Maya
authors: M
authors: Habre
authors: Nicolas
authors: N
authors: Ortonne
authors: Audrey
authors: A
authors: Colin
authors: Jean-Paul
authors: JP
authors: Meningaud
authors: Olivier
authors: O
authors: Chosidow
authors: Pierre
authors: P
authors: Wolkenstein
authors: Laurence
authors: L
authors: Valeyrie-Allanore
mesh_terms: D000293:Adolescent; D000328:Adult; D002114:Calcinosis / Q000473:pathology; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000473:pathology*; D005148:Facial Dermatoses / Q000209:etiology / Q000473:pathology*; D005260:Female; D005355:Fibrosis; D018859:Hair Follicle / Q000473:pathology*; D006801:Humans; D008297:Male; D012627:Sebaceous Glands / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D013262:Stevens-Johnson Syndrome / Q000150:complications*