title: Genomic and proteomic profiling for cancer diagnosis in dogs.
abstract: Global gene expression, whereby tumours are classified according to similar gene expression patterns or 'signatures' regardless of cell morphology or tissue characteristics, is being increasingly used in both the human and veterinary fields to assist in cancer diagnosis and prognosis. Many studies on canine tumours have focussed on RNA expression using techniques such as microarrays or next generation sequencing. However, proteomic studies combining two-dimensional polyacrylamide gel electrophoresis or two-dimensional differential gel electrophoresis with mass spectrometry have also provided a wealth of data on gene expression in tumour tissues. In addition, proteomics has been instrumental in the search for tumour biomarkers in blood and other body fluids.
authors: College of Medical, Veterinary and Life Sciences, School of Veterinary Medicine, University of Glasgow, Bearsden, Glasgow G61 1QH, UK. Electronic address: joanna.morris@glasgow.ac.uk.
authors: Joanna S
authors: JS
authors: Morris
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D004285:Dogs; D016678:Genome; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*; D020543:Proteome
chemical_list: D020543:Proteome
keywords: Biomarkers; Gene expression signatures; Mass spectrometry; Microarray; Next generation sequencing