title: Rapid T2 mapping of mouse heart using the carr-purcell-meiboom-gill sequence and compressed sensing reconstruction.
abstract: To develop and prove preliminary validation of a fast in vivo T2 mapping technique for mouse heart.
  
  
  
  Magnetic resonance imaging (MRI) experiments were performed on a 7T animal scanner. The standard Carr-Purcell-Meiboom-Gill (CPMG) sequence was modified to minimize the effect of stimulated echoes for accurate T2 quantification. The acquisition was further accelerated with the compressed sensing approach. The accuracy of the proposed method was first validated with both phantom experiments and numerical simulations. In vivo T2 measurement was performed on seven mice in a manganese-enhanced MRI study.
  
  
  
  In phantom studies, T2 values obtained with the modified CPMG sequence are in good agreement with the standard spin-echo method (P > 0.05). Numerical simulations further demonstrated that with the application of the compressed sensing approach, fast T2 quantification with a spatial resolution of 2.3 mm can be achieved at a high temporal resolution of 1 minute per slice. With the proposed technique, an average T2 value of 25 msec was observed for mouse heart at 7T and this number decreased significantly after manganese infusion (P < 0.001).
  
  
  
  A rapid T2 mapping technique was developed and assessed, which allows accurate T2 quantification of mouse heart at a temporal resolution of 1 minute per slice. J. Magn. Reson. Imaging 2016;44:375-382.
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
authors: Yong
authors: Y
authors: Chen
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
authors: Wen
authors: W
authors: Li
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
authors: Kai
authors: K
authors: Jiang
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
authors: Charlie Y
authors: CY
authors: Wang
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.|Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.|Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA.|Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, USA.
authors: Xin
authors: X
authors: Yu
mesh_terms: D000465:Algorithms; D000818:Animals; D057791:Cardiac Imaging Techniques / Q000379:methods*; D006352:Heart Ventricles; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
keywords: CPMG sequence; T2 mapping; cardiac imaging; compressed sensing; manganese-enhanced MRI