title: Discriminant analysis forecasting model of first trimester pregnancy outcomes developed by following 9,963 infertile patients after in vitro fertilization.
abstract: To investigate a forecasting method developed to predict first trimester pregnancy outcomes using the first routine ultrasound scan for early pregnancy on days 27-29 after ET and to determine whether to perform a repeated scan several days later based on this forecasting method.
  
  
  
  Prospective analysis.
  
  
  
  Infertile patients at an assisted reproductive technology center.
  
  
  
  A total of 9,963 patients with an early singleton pregnancy after in vitro fertilization (IVF)-ET.
  
  
  
  None.
  
  
  
  Ongoing pregnancy >12 weeks of gestation.
  
  
  
  The classification score of ongoing pregnancy was equal to (1.57 × Maternal age) + (1.01 × Mean sac diameter) + (-0.19 × Crown-rump length) + 25.15 (if cardiac activity is present) + 1.30 (if intrauterine hematomas are present) - 47.35. The classification score of early pregnancy loss was equal to (1.66 × Maternal age) + (0.84 × Mean sac diameter) + (-0.38 × Crown-rump length) + 8.69 (if cardiac activity is present) + 1.60 (if intrauterine hematomas are present) - 34.77. In verification samples, 94.44% of cases were correctly classified using these forecasting models.
  
  
  
  The discriminant forecasting models are accurate in predicting first trimester pregnancy outcomes based on the first scan for early pregnancy after ET. When the predictive result is ongoing pregnancy, a second scan can be postponed until 11-14 weeks if no symptoms of abdominal pain or vaginal bleeding are present. When the predictive results suggest early pregnancy loss, repeated scans are imperative to avoid a misdiagnosis before evacuating the uterus.
authors: Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha city, Hunan, People's Republic of China.
authors: Yan
authors: Y
authors: Yi
authors: Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha city, Hunan, People's Republic of China.
authors: Xihong
authors: X
authors: Li
authors: Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha city, Hunan, People's Republic of China.
authors: Yan
authors: Y
authors: Ouyang
authors: Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha city, Hunan, People's Republic of China; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha city, Hunan, People's Republic of China.
authors: Ge
authors: G
authors: Lin
authors: Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha city, Hunan, People's Republic of China; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha city, Hunan, People's Republic of China.
authors: Guangxiu
authors: G
authors: Lu
authors: Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha city, Hunan, People's Republic of China; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha city, Hunan, People's Republic of China. Electronic address: feigongzxxy@163.com.
authors: Fei
authors: F
authors: Gong
mesh_terms: D000328:Adult; D016002:Discriminant Analysis; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000639:trends*; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007247:Infertility, Female / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011261:Pregnancy Trimester, First / Q000502:physiology*
keywords: Discriminate analysis; early pregnancy loss; forecasting model; in vitro fertilization-embryo transfer; transvaginal ultrasound