title: Neuroendocrine carcinoma of the larynx with metastasis to the eyelid.
abstract: Neuroendocrine tumors are a rare type of neoplasms that comprise only 0.5% of all malignancies.¹ They usually arise from the gastrointestinal tract and the lung.¹,² Neuroendocrine carcinoma of the head and neck is a relatively rare malignancy described in the literature. The larynx is the most commonly affected region of the head and neck.³,⁴ Nevertheless, small-cell carcinoma comprises only 0.5% of all laryngeal cancers.⁵ Neuroendocrine carcinoma of the larynx carries variable prognosis depending on the histological subtype.⁶ Typical carcinoid rarely metastasizes, but atypical carcinoid and small-cell carcinoma have high rates of metastasis, usually in the lung and liver.² Cutaneous metastasis from neuroendocrine carcinoma is an extremely rare entity, with only few cases reported in the English literature.⁷,⁸ We report the case of an elderly man with recurrent laryngeal neuroendocrine carcinoma with metastasis to the eyelid.
authors: Department of Internal Medicine, Albany Medical Center, Albany, New York, USA. assih@mail.amc.edu.
authors: Hussein A
authors: HA
authors: Assi
authors: Department of Pathology, Albany Stratton VA Medical Center, Albany, New York, USA.
authors: Raina
authors: R
authors: Patel
authors: Division of Hematology/Oncology, Albany Stratton VA Medical Center, Albany, New York, USA.
authors: Syed
authors: S
authors: Mehdi
keywords: laryngeal cancer; neuroendocrine carcinoma; skin metastasis