title: Multidrug co-crystals: towards the development of effective therapeutic hybrids.
abstract: Co-crystals have garnered the interest of the pharmaceutical industry with the introduction of regulatory guidelines by the US Food and Drug Administration (FDA) as a result of expanded patent portfolios. The Phase II clinical success of tramadol and celecoxib co-crystal for the treatment of acute pain followed by a recent reflection paper published by the European Medicines Agency (EMA) have further boosted the development of drug-drug co-crystals. Here, we shed light on the developments of drug-drug co-crystals and highlight future perspectives for exploring new therapeutic hybrids deploying drug-drug, drug-nutraceuticals and drug-inorganic salt combinations with improved pharmaceutical and biopharmaceutical performance.
authors: Solid State Pharmaceutical Research Group (SSPRG), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
authors: Rajesh
authors: R
authors: Thipparaboina
authors: Solid State Pharmaceutical Research Group (SSPRG), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India; Solid State Pharmaceutical Cluster (SSPC), School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin, Ireland.
authors: Dinesh
authors: D
authors: Kumar
authors: Solid State Pharmaceutical Research Group (SSPRG), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
authors: Rahul B
authors: RB
authors: Chavan
authors: Solid State Pharmaceutical Research Group (SSPRG), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India. Electronic address: nalini.niperhyd@gov.in.
authors: Nalini R
authors: NR
authors: Shastri
mesh_terms: D003460:Crystallization; D004338:Drug Combinations; D004364:Pharmaceutical Preparations / Q000737:chemistry
chemical_list: D004338:Drug Combinations; D004364:Pharmaceutical Preparations