title: Efficacy of triclosan-coated sutures for reducing risk of surgical site infection in adults: a meta-analysis of randomized clinical trials.
abstract: BACKGROUND
  Surgical site infection (SSI) is the third most frequent type of nosocomial infections. Triclosan-coated sutures are often used to reduce the risk of SSI, but studies examining this have given conflicting results. Therefore, this meta-analysis was performed to assess the efficacy of triclosan-coated sutures for reducing risk of SSI in adults.
  
  
  METHODS
  PubMed, EMBASE, Google Scholar, and ClinicalTrials.gov were searched to identify randomized clinical trials evaluating triclosan-coated sutures for preventing SSI on patients 18 y or older.
  
  
  RESULTS
  Thirteen randomized clinical trials involving 5256 participants were included. Triclosan-coated sutures were associated with lower risk of SSI than uncoated sutures across all surgeries (risk ratio [RR] 0.76, 95% confidence interval [CI] 0.65-0.88, P < 0.001). Similar proportions of patients experienced wound dehiscence with either type of suture (RR 0.97, 95% CI 0.49-1.89, P = 0.92). Subgroup analysis showed lower risk of SSI with triclosan-coated sutures in abdominal surgeries (RR 0.70, 95% CI 0.50-0.99, P = 0.04) and group with prophylactic antibiotic (RR 0.79, 95% CI 0.63-0.99, P = 0.04). However, such risk reduction was not observed in cardiac surgeries, breast surgeries, or group without prophylactic antibiotic.
  
  
  CONCLUSIONS
  Triclosan-coated sutures can decrease the incidence of SSI in abdominal surgeries and might not interfere with wound healing process. Nevertheless, further studies are needed to examine whether triclosan-coated sutures are effective at preventing SSI in non-abdominal surgeries and to further study the interaction of antibiotic prophylaxis with triclosan-coated sutures.
authors: Experimental Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
authors: Jiao
authors: J
authors: Guo
authors: Anesthesia Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
authors: Ling-Hui
authors: LH
authors: Pan
authors: Cancer Registry Department, People's Hospital of Fusui County, Fusui, PR China.
authors: Yun-Xi
authors: YX
authors: Li
authors: Experimental Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
authors: Xiang-Di
authors: XD
authors: Yang
authors: Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
authors: Le-Qun
authors: LQ
authors: Li
authors: Experimental Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China. Electronic address: zcy_263@163.com.
authors: Chun-Yan
authors: CY
authors: Zhang
authors: Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China. Electronic address: zhongjianhong66@163.com.
authors: Jian-Hong
authors: JH
authors: Zhong
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013529:Surgical Wound Dehiscence / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013537:Sutures / Q000191:economics; D014260:Triclosan / Q000008:administration & dosage*
chemical_list: D000891:Anti-Infective Agents, Local; D014260:Triclosan
keywords: Antimicrobial; Antiseptic; Surgical site infection; Suture; Triclosan