title: Donor oocyte conception and pregnancy complications: a systematic review and meta-analysis.
abstract: BACKGROUND
  Observational studies showed that women with a donor oocyte (DO) pregnancy have an increased risk of pregnancy complications.
  
  
  OBJECTIVE
  Systematic review and meta-analysis to compare pregnancy complications of DO pregnancy with autologous oocyte in vitro fertilisation (IVF), and whether DO pregnancy acts as an independent risk factor.
  
  
  METHODS
  Online searches of databases from 1 January 1980 to 31 January 2015 were performed using a set of relevant keywords.
  
  
  METHODS
  All studies comparing pregnancy complications of women with donor oocyte IVF and autologous oocyte IVF were included.
  
  
  METHODS
  Data collected included demographics and pregnancy complications. Methodological quality assessment was performed using the Newcastle-Ottawa scale. Statistical analysis was performed using review manager 5.3 and stata 13.0. Meta-regression was performed for age.
  
  
  RESULTS
  In total, 11 studies (n = 81 752) were included. Ten studies (n = 11 539) examined the primary outcome. The risk of developing hypertensive disorders in pregnancy was significantly higher for DO pregnancy (odds ratio, OR 3.92; 95% confidence interval, 95% CI 3.21-4.78). Further subgroup analysis for singleton and twin pregnancies showed that the risk was significantly higher for DO pregnancy in each group. Secondary outcomes including small for gestational age (OR 1.81), caesarean section (OR 2.71), and preterm delivery (OR 1.34) were significantly higher with DO pregnancy. Meta-regression for the covariate of age suggested that risk was independent of age.
  
  
  CONCLUSIONS
  Donor oocyte pregnancy acts as an independent risk factor for pregnancy complications, including hypertensive disorders, small for gestational age, and preterm delivery. Women should be counselled carefully before undergoing DO-assisted conception.
  
  
  CONCLUSIONS
  Donor oocyte conception is an independent risk factor for obstetric complications.
authors: University Hospitals of Leicester NHS Trust, Leicester, UK.|Leicester Fertility Centre, University Hospitals of Leicester NHS Trust, Leicester, UK.
authors: Y B
authors: YB
authors: Jeve
authors: Leicester Fertility Centre, University Hospitals of Leicester NHS Trust, Leicester, UK.|University of Leicester, Leicester, UK.
authors: N
authors: N
authors: Potdar
authors: Homerton University Hospital NHS Foundation Trust, London, UK.
authors: A
authors: A
authors: Opoku
authors: University Hospitals of Leicester NHS Trust, Leicester, UK.
authors: M
authors: M
authors: Khare
mesh_terms: D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology*; D007236:Infant, Small for Gestational Age; D008423:Maternal Age; D016017:Odds Ratio; D018587:Oocyte Donation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology*; D012307:Risk Factors
keywords: Donor oocyte pregnancy; in vitro fertilisation; pre-elampsia; pregnancy-induced hypertension