title: DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior.
abstract: DNA origami is a DNA-based nanotechnology that utilizes programmed combinations of short complementary oligonucleotides to fold a large single strand of DNA into precise 2D and 3D shapes. The exquisite nanoscale shape control of this inherently biocompatible material is combined with the potential to spatially address the origami structures with diverse cargoes including drugs, antibodies, nucleic acid sequences, small molecules, and inorganic particles. This programmable flexibility enables the fabrication of precise nanoscale devices that have already shown great potential for biomedical applications such as: drug delivery, biosensing, and synthetic nanopore formation. Here, the advances in the DNA-origami field since its inception several years ago are reviewed with a focus on how these DNA-nanodevices can be designed to interact with cells to direct or probe their behavior.
authors: Department of Anatomy, Tissue Engineering Research Group and Advanced Materials and Bioengineering Research Center, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, Ireland.
authors: Cathal J
authors: CJ
authors: Kearney
authors: Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
authors: Christopher R
authors: CR
authors: Lucas
authors: Department of Anatomy, Tissue Engineering Research Group and Advanced Materials and Bioengineering Research Center, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, Ireland.
authors: Fergal J
authors: FJ
authors: O'Brien
authors: Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
authors: Carlos E
authors: CE
authors: Castro
mesh_terms: D004247:DNA / Q000737:chemistry*; D058608:Nanopores; D049329:Nanostructures; D036103:Nanotechnology; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides
chemical_list: D009841:Oligonucleotides; D004247:DNA
keywords: DNA origami; biosensing; drug delivery; nanoparticles; nanopores