title: [Hypothyroidism during pregnancy risks the child's neurocognitive development. New guidelines and remaining knowledge gaps].
abstract: Thyroid abnormalities are common during pregnancy and can affect pregnancy outcome. In 2012, the working group for endocrinology was assigned by SFOG to develop evidence based guidelines for their management. There is high quality evidence that untreated clinical hypothyroidism increases the risk of pregnancy and fetal complications. Subclinical hypothyroidism is associated with pregnancy complications. The presence of TPO-antibodies is linked to miscarriage and premature birth. It is uncertain whether subclinical hypothyroidism/maternal TPO-antibodies adversely affect the child's neurocognitive development. Reference intervals for TSH among pregnant women in Sweden need to be established.
authors: Uppsala Universitet - Inst för Kvinnors och Barns Hälsa Uppsala, Sweden Uppsala Universitet - Inst för Kvinnors och Barns Hälsa Uppsala, Sweden.
authors: Alkistis
authors: A
authors: Skalkidou
authors: Kvinnokliniken, Norrlands universitetssjukhus - Umea, Sweden Kvinnokliniken, Norrlands universitetssjukhus - Umea, Sweden.
authors: Marie
authors: M
authors: Bixo
authors: Kvinnokliniken, Danderyds sjukhus - Stockholm, Sweden Kvinnokliniken, Danderyds sjukhus - Stockholm, Sweden.
authors: Ann-Charlotte
authors: AC
authors: Sköldebrand Sparre
authors: Sahlgreska Universtitetssjukhus - Kvinnosjukvården Göteborg, Sweden Sahlgreska Universtitetssjukhus - Göteborg, Sweden.
authors: Annika
authors: A
authors: Strandell
authors: Kvinnokliniken, Karolinska Universitetssjukhuset, - Stockholm, Sweden Kvinnokliniken, Karolinska Universitetssjukhuset, - Stockholm, Sweden.
authors: Angelica
authors: A
authors: Lindén Hirschberg
authors: Endokrinsektionen, Medicinkliniken, Sahlgrenska Universitetssjukhuset - Göteborg, Sweden Endokrinsektionen, Medicinkliniken, Sahlgrenska Universitetssjukhuset - Göteborg, Sweden.
authors: Helena
authors: H
authors: Filipsson Nyström
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D007453:Iodide Peroxidase / Q000276:immunology; D019965:Neurocognitive Disorders / Q000209:etiology; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012016:Reference Values; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood
chemical_list: D001323:Autoantibodies; D013972:Thyrotropin; D007453:Iodide Peroxidase