title: Biophysical EPR Studies Applied to Membrane Proteins.
abstract: Membrane proteins are very important in controlling bioenergetics, functional activity, and initializing signal pathways in a wide variety of complicated biological systems. They also represent approximately 50% of the potential drug targets. EPR spectroscopy is a very popular and powerful biophysical tool that is used to study the structural and dynamic properties of membrane proteins. In this article, a basic overview of the most commonly used EPR techniques and examples of recent applications to answer pertinent structural and dynamic related questions on membrane protein systems will be presented.
authors: Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, United States of America.
authors: Indra D
authors: ID
authors: Sahu
authors: Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, United States of America.
authors: Gary A
authors: GA
authors: Lorigan
keywords: DEER; Electron paramagnetic resonance spectroscopy; Membrane proteins; Site-directed spin labeling; Structural topology and dynamics