title: Quadruple Vessel Coronary Artery Bypass Grafting in a 14-Year-Old Child With Plasminogen Activator Inhibitor-1 4G/4G Gene Polymorphism.
abstract: Myocardial ischemia due to coronary artery disease is an extremely rare condition in childhood and adolescence. Absence of obvious serious risk factors remains a challenge to modern cardiology. We present the case of a 14-year-old boy who underwent quadruple-vessel coronary artery bypass grafting with bilateral pedicled internal mammary artery and bilateral radial artery grafting. We try to highlight a rare but important 4G variant PAI-1 (SERPINE 1) gene mutation as the etiology of severe coronary artery disease in our patient. To the best of our knowledge, he is one of the youngest patients who underwent coronary artery bypass surgery with 4 arterial grafts.
authors: New York Medical College and Westchester Medical Center, Valhalla, NY, USA draginjacvetkovic@yahoo.com.
authors: Draginja
authors: D
authors: Cvetkovic
authors: New York Medical College and Westchester Medical Center, Valhalla, NY, USA.
authors: Rocco
authors: R
authors: Lafaro
authors: New York Medical College and Westchester Medical Center, Valhalla, NY, USA.
authors: Joseph
authors: J
authors: Giamelli
authors: New York Medical College and Westchester Medical Center, Valhalla, NY, USA.
authors: Sett
authors: S
authors: Suvro
authors: New York Medical College and Westchester Medical Center, Valhalla, NY, USA.
authors: Markus
authors: M
authors: Erb
authors: New York Medical College and Westchester Medical Center, Valhalla, NY, USA.
authors: Saman
authors: S
authors: Yaghoubian
mesh_terms: D000293:Adolescent; D001026:Coronary Artery Bypass / Q000379:methods*; D003324:Coronary Artery Disease / Q000235:genetics / Q000601:surgery*; D004562:Electrocardiography; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D017395:Plasminogen Activator Inhibitor 1
keywords: 4G variant of PAI-1 (SERPINE1) gene; coronary artery bypass graft (CABG); coronary artery disease (CAD) in children