title: ADPr-ChAP: Mapping ADP-Ribosylation onto the Genome.
abstract: In this issue of Molecular Cell, Bartolomei et al. (2016) describe a chromatin affinity precipitation method using well-characterized ADP-ribose binding domains to provide the first genome-wide view of ADP-ribosylated chromatin. Here, we discuss its potential applications and the remaining challenges ahead.
authors: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
authors: Robert Lyle
authors: RL
authors: McPherson
authors: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: anthony.leung@jhu.edu.
authors: Anthony K L
authors: AKL
authors: Leung
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism*; D047369:Chromatin Immunoprecipitation / Q000379:methods*; D006801:Humans
chemical_list: D002843:Chromatin; D000246:Adenosine Diphosphate Ribose