title: Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research.
abstract: Research challenges associated with understanding HIV persistence during antiretroviral therapy can be categorized as temporal, spatial and combinatorial. Temporal research challenges relate to the timing of events during establishment and maintenance of HIV persistence. Spatial research challenges regard the anatomical locations and cell subsets that harbor persistent HIV. Combinatorial research challenges pertain to the order of administration, timing of administration and specific combinations of compounds to be administered during HIV eradication therapy. Overcoming these challenges will improve our understanding of HIV persistence and move the field closer to achieving eradication of persistent HIV. Given that humanized mice and non-human primate HIV models permit rigorous control of experimental conditions, these models have been used extensively as in vivo research platforms for directly addressing these research challenges. The aim of this manuscript is to provide a comprehensive review of these recent translational advances made in animal models of HIV persistence.
authors: Institute of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, 8200, Aarhus, Denmark. pade@clin.au.dk.|Department of Infectious Diseases, Aarhus University Hospital, Skejby, Aarhus, Denmark. pade@clin.au.dk.|Aarhus Institute for Advanced Studies, Aarhus University, Aarhus, Denmark. pade@clin.au.dk.
authors: Paul W
authors: PW
authors: Denton
authors: Institute of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, 8200, Aarhus, Denmark. olesoega@rm.dk.|Department of Infectious Diseases, Aarhus University Hospital, Skejby, Aarhus, Denmark. olesoega@rm.dk.
authors: Ole S
authors: OS
authors: Søgaard
authors: Institute of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, 8200, Aarhus, Denmark. marttols@rm.dk.|Department of Infectious Diseases, Aarhus University Hospital, Skejby, Aarhus, Denmark. marttols@rm.dk.
authors: Martin
authors: M
authors: Tolstrup
mesh_terms: D000818:Animals; D035843:Biomedical Research; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D013997:Time Factors