title: Pregnane steroids from a gorgonian coral Subergorgia suberosa with anti-flu virus effects.
abstract: Five new pregnane-type steroids namely subergorgols T-X (1-5) and three known analogues (6-8) were isolated from a gorgonian coral Subergorgia suberosa. The structures of new compounds were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analyses, in association with photochemical transformation and ECD methods for the configurational assignment. Compounds 1-8 were evaluated for the inhibitory effects against H1N1 virus infected in MDCK cells, while subergorgols T-U and 1,2-dehydroprogesterone exerted potent inhibition against A/WSN/33 virus.
authors: State Key Laboratory of Natural and Biomimetic Drugs, Institute of Ocean Research, Peking University, Beijing 100191, PR China.
authors: Wei
authors: W
authors: Cheng
authors: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China.
authors: Jinwei
authors: J
authors: Ren
authors: State Key Laboratory of Natural and Biomimetic Drugs, Institute of Ocean Research, Peking University, Beijing 100191, PR China.
authors: Qixi
authors: Q
authors: Huang
authors: State Key Laboratory of Natural and Biomimetic Drugs, Institute of Ocean Research, Peking University, Beijing 100191, PR China.
authors: Hailin
authors: H
authors: Long
authors: State Key Laboratory of Natural and Biomimetic Drugs, Institute of Ocean Research, Peking University, Beijing 100191, PR China.
authors: Hongwei
authors: H
authors: Jin
authors: State Key Laboratory of Natural and Biomimetic Drugs, Institute of Ocean Research, Peking University, Beijing 100191, PR China.
authors: Liangren
authors: L
authors: Zhang
authors: Guangxi University of Chinese Medicine, Nanning 530001, PR China.
authors: Huagang
authors: H
authors: Liu
authors: National Museum of Natural History Naturalis, 2300 RA Leiden, The Netherlands.
authors: Leen
authors: L
authors: van Ofwegen
authors: State Key Laboratory of Natural and Biomimetic Drugs, Institute of Ocean Research, Peking University, Beijing 100191, PR China. Electronic address: whlin@bjmu.edu.cn.
authors: Wenhan
authors: W
authors: Lin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D004285:Dogs; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D061985:Madin Darby Canine Kidney Cells; D011278:Pregnanes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011278:Pregnanes
keywords: Anti-virus effects; Gorgonian coral; Structural elucidation; Subergorgia suberosa; Subergorgols T–X