title: A case of miriplatin-induced lung injury.
abstract: A 69-year-old man with an 8-year history of hepatocellular carcinoma (HCC) was hospitalized for treatment of recurrent tumour. In 2010, the first transcatheter arterial chemoembolization (TACE) using miriplatin with agents (Lipiodol Ultra-Fluid) was performed and did not occur any adverse events. In 2014, since his HCC recurred, the TACE using miriplatin with agents was performed. Following this therapy, pyrexia occurred on day 3, followed by respiratory failure with cough and dyspnea on day 5. Chest radiography revealed scattered infiltration in the right upper lung fields, and chest computed tomography revealed ground grass attenuations, indicating fibrotic non-specific interstitial pneumonia. These findings progressively deteriorated, and a diagnosis of miriplatin-induced lung injury was made. His respiratory failure also progressively deteriorated. Treatment with pulse methylprednisolone therapy resulted in a dramatic improvement in both patient symptoms and radiological abnormalities.
authors: Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan. Electronic address: fumiokumasawa@gmail.com.
authors: Fumio
authors: F
authors: Kumasawa
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Takao
authors: T
authors: Miura
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Toshimi
authors: T
authors: Takahashi
authors: Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Daisuke
authors: D
authors: Endo
authors: Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Takashi
authors: T
authors: Ohki
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Hiroshi
authors: H
authors: Nakagawara
authors: Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Shuichiro
authors: S
authors: Maruoka
authors: Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Ichiro
authors: I
authors: Tsujino
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Ogawa
authors: O
authors: Masahiro
authors: Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Yasuhiro
authors: Y
authors: Gon
authors: Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Noriaki
authors: N
authors: Takahashi
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Mitsuhiko
authors: M
authors: Moriyama
authors: Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors: Shu
authors: S
authors: Hashimoto
mesh_terms: D000368:Aged; D006801:Humans; D055370:Lung Injury / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D009944:Organoplatinum Compounds; C406530:miriplatin
keywords: Drug-induced lung injury; Interstitial pneumonia; Miriplatin; Steroid