title: Dopaminergic Therapy Modulates Cortical Perfusion in Parkinson Disease With and Without Dementia According to Arterial Spin Labeled Perfusion Magnetic Resonance Imaging.
abstract: Arterial spin labeling (ASL) magnetic resonance imaging analyses allow for the quantification of altered cerebral blood flow, and provide a novel means of examining the impact of dopaminergic treatments. The authors examined the cerebral perfusion differences among 17 Parkinson disease (PD) patients, 17 PD with dementia (PDD) patients, and 17 healthy controls and used ASL-MRI to assess the effects of dopaminergic therapies on perfusion in the patients. The authors demonstrated progressive widespread cortical hypoperfusion in PD and PDD and robust effects for the dopaminergic therapies. Specifically, dopaminergic medications further decreased frontal lobe and cerebellum perfusion in the PD and PDD groups, respectively. These patterns of hypoperfusion could be related to cognitive dysfunctions and disease severity. Furthermore, desensitization to dopaminergic therapies in terms of cortical perfusion was found as the disease progressed, supporting the concept that long-term therapies are associated with the therapeutic window narrowing. The highly sensitive pharmaceutical response of ASL allows clinicians and researchers to easily and effectively quantify the absolute perfusion status, which might prove helpful for therapeutic planning.
authors: From the Department of Diagnostic Radiology (W-CL, P-CC, H-LC, M-HC, Y-WC); Department of Nuclear Medicine (Y-CH); Department of Neurology (N-WT, T-KL, C-HL); Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University (H-LC); Department of Neurosurgery (H-CW); and Brain Research Center, National Yang-Ming University, Taipei, Taiwan (K-HC).
authors: Wei-Che
authors: WC
authors: Lin
authors: Pei-Chin
authors: PC
authors: Chen
authors: Yung-Cheng
authors: YC
authors: Huang
authors: Nai-Wen
authors: NW
authors: Tsai
authors: Hsiu-Ling
authors: HL
authors: Chen
authors: Hung-Chen
authors: HC
authors: Wang
authors: Tsu-Kung
authors: TK
authors: Lin
authors: Kun-Hsien
authors: KH
authors: Chou
authors: Meng-Hsiang
authors: MH
authors: Chen
authors: Yi-Wen
authors: YW
authors: Chen
authors: Cheng-Hsien
authors: CH
authors: Lu
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003704:Dementia / Q000150:complications / Q000188:drug therapy*; D015259:Dopamine Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D015259:Dopamine Agents