title: Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases.
abstract: tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs.
authors: Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors: Yu
authors: Y
authors: Fu
authors: miRcore, Ann Arbor, MI 48105, USA.
authors: Inhan
authors: I
authors: Lee
authors: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors: Yong Sun
authors: YS
authors: Lee
authors: Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.; Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.; The Institute of Translational Science, University of Texas Medical Branch, Galveston, TX 77555, USA.; The Institute for Human Infections & Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors: Xiaoyong
authors: X
authors: Bao
keywords: RSV replication, tRNA, tRNA-derived RNA fragments; neoplasms; neurodegenerative diseases