title: Effects of Peroxisome Proliferator-Activated Receptor-δ Agonist on Cardiac Healing after Myocardial Infarction.
abstract: Peroxisome proliferator-activated receptor-delta (PPAR-δ)-dependent signaling is associated with rapid wound healing in the skin. Here, we investigated the therapeutic effects of PPAR-δ-agonist treatment on cardiac healing in post-myocardial infarction (MI) rats. Animals were assigned to the following groups: sham-operated control group, left anterior descending coronary artery ligation (MI) group, or MI with administration of the PPAR-δ agonist GW610742 group. GW610742 (1 mg/kg) was administrated intraperitoneally after the operation and repeated every 3 days. Echocardiographic data showed no differences between the two groups in terms of cardiac function and remodeling until 4 weeks. However, the degrees of angiogenesis and fibrosis after MI were significantly higher in the GW610742-treated rats than in the untreated MI rats at 1 week following MI, which changes were not different at 2 weeks after MI. Naturally, PPAR-δ expression in infarcted myocardium was highest increased in 3 day after MI and then disappeared in 14 day after MI. GW610742 increased myofibroblast differentiation and transforming growth factor-beta 2 expression in the infarct zone at 7 days after MI. GW610742 also increased bone marrow-derived mesenchymal stem cell (MSC) recruitment in whole myocardium, and increased serum platelet-derived growth factor B, stromal-derived factor-1 alpha, and matrix metallopeptidase 9 levels at day 3 after MI. PPAR-δ agonists treatment have the temporal effect on early fibrosis of infarcted myocardium, which might not sustain the functional and structural beneficial effect.
authors: Division of Cardiology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.|Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors: Jeong Rang
authors: JR
authors: Park
authors: Division of Cardiology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.|Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors: Jong Hwa
authors: JH
authors: Ahn
authors: Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, Republic of Korea.
authors: Myeong Hee
authors: MH
authors: Jung
authors: Division of Cardiology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.|Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors: Jin-Sin
authors: JS
authors: Koh
authors: Division of Cardiology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.|Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors: Yongwhi
authors: Y
authors: Park
authors: Division of Cardiology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.|Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors: Seok-Jae
authors: SJ
authors: Hwang
authors: Division of Cardiology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.|Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors: Young-Hoon
authors: YH
authors: Jeong
authors: Division of Cardiology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.|Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors: Choong Hwan
authors: CH
authors: Kwak
authors: Department of Pharmacology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors: Young Soo
authors: YS
authors: Lee
authors: Department of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea.
authors: Han Geuk
authors: HG
authors: Seo
authors: Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.|Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, Republic of Korea.
authors: Jin Hyun
authors: JH
authors: Kim
authors: Division of Cardiology, Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.|Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors: Jin-Yong
authors: JY
authors: Hwang
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation; D002465:Cell Movement; D054377:Chemokine CXCL12 / Q000378:metabolism; D004452:Echocardiography; D005355:Fibrosis / Q000503:physiopathology; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles; D007263:Infusions, Parenteral; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000473:pathology; D058628:Myofibroblasts / Q000166:cytology / Q000187:drug effects; D047494:PPAR delta / Q000819:agonists*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D013844:Thiazoles / Q000494:pharmacology*; D053781:Transforming Growth Factor beta2 / Q000378:metabolism; D020257:Ventricular Remodeling / Q000187:drug effects
chemical_list: C575935:CXCL12 protein, rat; D054377:Chemokine CXCL12; C503394:GW 610742; D047494:PPAR delta; D010982:Platelet-Derived Growth Factor; C509043:Tgfb2 protein, rat; D013844:Thiazoles; D053781:Transforming Growth Factor beta2; D020780:Matrix Metalloproteinase 9; C572337:Mmp9 protein, rat