title: DNA-Based Sensor Particles Enable Measuring Light Intensity in Single Cells.
abstract: "Lab on a particle" architecture is employed in designing a light nanosensor. Light-sensitive protecting groups are installed on DNA, which is encapsulated in silica particles, qualifying as a self-sufficient light sensor. The nanosensors allow measuring light intensity and duration in very small volumes, such as single cells, and store the irradiation information until readout.
authors: Institute for Chemical and Bioengineering, ETH Zürich, Vladimir-Prelog-Weg 1, 8093, Zürich, Switzerland.
authors: Gediminas
authors: G
authors: Mikutis
authors: Institute for Chemical and Bioengineering, ETH Zürich, Vladimir-Prelog-Weg 1, 8093, Zürich, Switzerland.
authors: Carlos A
authors: CA
authors: Mora
authors: Institute for Chemical and Bioengineering, ETH Zürich, Vladimir-Prelog-Weg 1, 8093, Zürich, Switzerland.
authors: Michela
authors: M
authors: Puddu
authors: Institute for Chemical and Bioengineering, ETH Zürich, Vladimir-Prelog-Weg 1, 8093, Zürich, Switzerland.
authors: Daniela
authors: D
authors: Paunescu
authors: Institute for Chemical and Bioengineering, ETH Zürich, Vladimir-Prelog-Weg 1, 8093, Zürich, Switzerland.
authors: Robert N
authors: RN
authors: Grass
authors: Institute for Chemical and Bioengineering, ETH Zürich, Vladimir-Prelog-Weg 1, 8093, Zürich, Switzerland.
authors: Wendelin J
authors: WJ
authors: Stark
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004149:Dioxoles / Q000737:chemistry; D004926:Escherichia coli / Q000235:genetics / Q000302:isolation & purification; D008853:Microscopy; D036103:Nanotechnology; D048488:Paramecium caudatum / Q000235:genetics / Q000302:isolation & purification; D060888:Real-Time Polymerase Chain Reaction; D059010:Single-Cell Analysis / Q000379:methods*; D014466:Ultraviolet Rays
chemical_list: C569799:6-nitropiperonyloxymethyl chloride; D004149:Dioxoles; D004247:DNA
keywords: caged oligonucleotides; light sensors; nanosensor; sensor particles; single cell analysis