title: Increased Ghrelin Levels and Unchanged Adipocytokine Levels in Major Depressive Disorder.
abstract: One of the hypotheses of the pathophysiology of major depressive disorder (MDD) proposes that there is a relationship between adipocytokine and ghrelin levels and depression.
  
  
  
  Patients with major depression with a BMI ≤25 kg/m2between the ages of 11 and 18 years (n = 30) were compared with a healthy control group (n = 30). Both groups were evaluated across a pretreatment period (MD-PT) and an improved period (MD-I). We measured serum leptin, adiponectin, resistin, and ghrelin levels and other parameters related to metabolic syndrome, such as glucose, insulin, insulin resistance (homeostasis model assessment [HOMA]), triglycerides (TG), and total cholesterol (TCHOL).
  
  
  
  Leptin, adiponectin, and resistin levels did not differ across groups; however, ghrelin levels were increased in the MD-I group compared with the control and MD-PT groups (p < 0.05). HOMA levels were also higher in the MD-PT group than in the control group (p < 0.05). After treatment, there was no difference in this measurement.
  
  
  
  The relationship between adipocytokines and major depression may be dependent on ghrelin levels as a result of antidepressant treatment and subsequent obesity.
authors: 1 Medical Biochemistry Department, Faculty of Medicine, Ondokuz Mayıs University , Samsun, Turkey .
authors: Özgür Korhan
authors: ÖK
authors: Tunçel
authors: 2 Child and Adolescent Psychiatry Department, Faculty of Medicine, Ondokuz Mayıs University , Samsun, Turkey .
authors: Seher
authors: S
authors: Akbaş
authors: 1 Medical Biochemistry Department, Faculty of Medicine, Ondokuz Mayıs University , Samsun, Turkey .
authors: Birşen
authors: B
authors: Bilgici
mesh_terms: D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D003865:Major Depressive Disorder / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000453:epidemiology
chemical_list: D054392:Adipokines; D000928:Antidepressive Agents; D001786:Blood Glucose; D054439:Ghrelin; D007328:Insulin
keywords: adipocytokine; depression; ghrelin; insulin resistance; sertraline