title: Increased frequency and severity of restless legs syndrome in patients with neuromyelitis optica spectrum disorder.
abstract: OBJECTIVE
  To investigate the comorbidity of restless legs syndrome (RLS) and neuromyelitis optica spectrum disorder (NMOSD).
  
  
  METHODS
  This study enrolled 159 NMOSD patients and 153 age- and gender-matched healthy controls. All participants completed a questionnaire based on the updated International Restless Legs Syndrome Study Group consensus criteria, the International RLS Severity scale, Epworth Sleepiness Scale, Fatigue Severity Scale, and Pittsburgh Sleep Quality Index, and were subsequently interviewed by a neurologist. The frequency and features of RLS were compared between NMOSD patients and healthy controls. The clinical and radiological characteristics of the NMOSD patients with and without RLS were also compared.
  
  
  RESULTS
  The frequency and severity of RLS were significantly higher in NMOSD patients than in healthy controls (p = 0.015 for both) and NMOSD patients with RLS had a longer disease duration and more severe disability than those without RLS.
  
  
  CONCLUSIONS
  This study indicated importance of considering RLS in NMOSD patients.
authors: Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea.
authors: Jae-Won
authors: JW
authors: Hyun
authors: Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea.
authors: Su-Hyun
authors: SH
authors: Kim
authors: Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea.
authors: In Hye
authors: IH
authors: Jeong
authors: Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea.
authors: AeRan
authors: A
authors: Joung
authors: Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea.
authors: Ji-Hee
authors: JH
authors: Kim
authors: Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea.
authors: Hyo Jin
authors: HJ
authors: Cho
authors: Department of Neurology, Dankook University College of Medicine, Dankook University Hospital, Cheonan, Republic of Korea.
authors: Jee Hyun
authors: JH
authors: Kim
authors: Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea. Electronic address: hojinkim@ncc.re.kr.
authors: Ho Jin
authors: HJ
authors: Kim
mesh_terms: D000328:Adult; D005221:Fatigue / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000150:complications*; D012148:Restless Legs Syndrome / Q000150:complications*; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D011795:Surveys and Questionnaires
keywords: Neuromyelitis optica spectrum disorder; Restless legs syndrome