title: Intestinal Microbiota in Pediatric Surgical Cases Administered Bifidobacterium Breve: A Randomized Controlled Trial.
abstract: The efficacy of perioperative probiotic administration has been reported in adults. We examined the effects of orally administered Bifidobacterium breve strain Yakult (BBG-01) on outcomes in pediatric surgical cases by assessing intestinal and blood microbiota. BBG-01 was well tolerated without adverse effects, and postoperative infectious complications were significantly decreased. Fecal analysis showed increased Bifidobacterium and decreased Enterobacteriaceae, Clostridium difficile, and Pseudomonas. Concentrations of fecal acetic acid were significantly increased, maintaining fecal pH at <7.0. The incidence of detecting bacteria in blood was significantly reduced. BBG-01 improved the intestinal environment, and may be implicated in suppressing bacterial translocation.
authors: *Department of Pediatric Surgery, Juntendo University Urayasu Hospital, Chiba, Japan†Department of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine‡Yakult Central Institute, Yakult Honsha Co, Ltd., Tokyo, Japan§Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan||Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors: Tadaharu
authors: T
authors: Okazaki
authors: Takashi
authors: T
authors: Asahara
authors: Atsuyuki
authors: A
authors: Yamataka
authors: Yuki
authors: Y
authors: Ogasawara
authors: Geoffrey J
authors: GJ
authors: Lane
authors: Koji
authors: K
authors: Nomoto
authors: Satoru
authors: S
authors: Nagata
authors: Yuichiro
authors: Y
authors: Yamashiro
mesh_terms: D000293:Adolescent; D001644:Bifidobacterium; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008297:Male; D019990:Perioperative Care; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control; D019936:Probiotics / Q000008:administration & dosage*; D013514:Surgical Procedures, Operative; D016896:Treatment Outcome