title: Probing Chromatin-modifying Enzymes with Chemical Tools.
abstract: Chromatin is the universal template of genetic information in all eukaryotic organisms. Chemical modifications of the DNA-packaging histone proteins and the DNA bases are crucial signaling events in directing the use and readout of eukaryotic genomes. The enzymes that install and remove these chromatin modifications as well as the proteins that bind these marks govern information that goes beyond the sequence of DNA. Therefore, these so-called epigenetic regulators are intensively studied and represent promising drug targets in modern medicine. We summarize and discuss recent advances in the field of chemical biology that have provided chromatin research with sophisticated tools for investigating the composition, activity, and target sites of chromatin modifying enzymes and reader proteins.
authors: King Abdullah University of Science and Technology (KAUST) , Environmental Epigenetics Program, Thuwal 23955-6900, Saudi Arabia.|Max Planck Institute for Biophysical Chemistry , Laboratory of Chromatin Biochemistry, Am Fassberg 11, 37077 Göttingen, Germany.
authors: Wolfgang
authors: W
authors: Fischle
authors: Interfaculty Institute of Biochemistry (IFIB), University of Tübingen , Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany.
authors: Dirk
authors: D
authors: Schwarzer
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000235:genetics; D044127:Epigenesis, Genetic / Q000502:physiology*; D042421:Histone Code; D006657:Histones / Q000235:genetics; D008745:Methylation
chemical_list: D002843:Chromatin; D006657:Histones; D004247:DNA