title: Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation.
abstract: Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry), and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone to stimulate osteogenesis. Surface-modified wrap-implants placed around rabbit tibias osseointegrated by 6 w. Finally, patient-specific constructs designed to support dental implants produced via AM and surface-processing were implanted on edentulous mandibular bone. 3 and 8 month post-operative images showed new bone formation and osseointegration of the device and indicated stability of the dental implants.
authors: Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, U.S.A.
authors: D J
authors: DJ
authors: Cohen
authors: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, U.S.A.|Department of Biomedical Engineering, Peking University, Beijing, China.
authors: A
authors: A
authors: Cheng
authors: Department of Oral and Maxillofacial Surgery, Tel Aviv University, Tel Aviv, Israel.
authors: A
authors: A
authors: Kahn
authors: Tipul Behiuch Private Clinic, Tel Aviv, Israel.
authors: M
authors: M
authors: Aviram
authors: Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, U.S.A.
authors: A J
authors: AJ
authors: Whitehead
authors: Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, U.S.A.
authors: S L
authors: SL
authors: Hyzy
authors: Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, U.S.A.
authors: R M
authors: RM
authors: Clohessy
authors: Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, U.S.A.|Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, U.S.A.
authors: B D
authors: BD
authors: Boyan
authors: Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, U.S.A.|Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, U.S.A.
authors: Z
authors: Z
authors: Schwartz
mesh_terms: D000497:Alloys; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D001863:Bone Screws; D002460:Cell Line; D015921:Dental Implants; D004867:Equipment Design; D006801:Humans; D008297:Male; D016348:Osseointegration / Q000187:drug effects*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects*; D016062:Porosity; D011817:Rabbits; D051381:Rats; D011923:Rats, Nude; D017207:Rats, Sprague-Dawley; D012886:Skull / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D013499:Surface Properties; D013977:Tibia / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D015921:Dental Implants; C031462:titanium alloy (TiAl6V4); D014025:Titanium