title: Chimpanzee Adenovirus Vaccine Provides Multispecies Protection against Rift Valley Fever.
abstract: Rift Valley Fever virus (RVFV) causes recurrent outbreaks of acute life-threatening human and livestock illness in Africa and the Arabian Peninsula. No licensed vaccines are currently available for humans and those widely used in livestock have major safety concerns. A 'One Health' vaccine development approach, in which the same vaccine is co-developed for multiple susceptible species, is an attractive strategy for RVFV. Here, we utilized a replication-deficient chimpanzee adenovirus vaccine platform with an established human and livestock safety profile, ChAdOx1, to develop a vaccine for use against RVFV in both livestock and humans. We show that single-dose immunization with ChAdOx1-GnGc vaccine, encoding RVFV envelope glycoproteins, elicits high-titre RVFV-neutralizing antibody and provides solid protection against RVFV challenge in the most susceptible natural target species of the virus-sheep, goats and cattle. In addition we demonstrate induction of RVFV-neutralizing antibody by ChAdOx1-GnGc vaccination in dromedary camels, further illustrating the potency of replication-deficient chimpanzee adenovirus vaccine platforms. Thus, ChAdOx1-GnGc warrants evaluation in human clinical trials and could potentially address the unmet human and livestock vaccine needs.
authors: The Jenner Institute, University of Oxford, Oxford, UK.|Centre for Research in Therapeutic Sciences and, Institute for Healthcare Management, Strathmore University, Nairobi, Kenya.
authors: George M
authors: GM
authors: Warimwe
authors: International Livestock Research Institute (ILRI), Nairobi, Kenya.
authors: Joseph
authors: J
authors: Gesharisha
authors: The Pirbright Institute, Pirbright, Woking, UK.
authors: B Veronica
authors: BV
authors: Carr
authors: International Livestock Research Institute (ILRI), Nairobi, Kenya.
authors: Simeon
authors: S
authors: Otieno
authors: International Livestock Research Institute (ILRI), Nairobi, Kenya.
authors: Kennedy
authors: K
authors: Otingah
authors: The Jenner Institute, University of Oxford, Oxford, UK.
authors: Danny
authors: D
authors: Wright
authors: The Pirbright Institute, Pirbright, Woking, UK.
authors: Bryan
authors: B
authors: Charleston
authors: International Livestock Research Institute (ILRI), Nairobi, Kenya.
authors: Edward
authors: E
authors: Okoth
authors: Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CISA), Madrid, Spain.
authors: Lopez-Gil
authors: LG
authors: Elena
authors: Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CISA), Madrid, Spain.
authors: Gema
authors: G
authors: Lorenzo
authors: Qassim University, Qassim, Saudi Arabia.
authors: El-Behiry
authors: el-B
authors: Ayman
authors: The Jenner Institute, University of Oxford, Oxford, UK.|King Abdullah International Research Center, Riyadh, Saudi Arabia.
authors: Naif K
authors: NK
authors: Alharbi
authors: Qassim University, Qassim, Saudi Arabia.
authors: Musaad A
authors: MA
authors: Al-dubaib
authors: Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CISA), Madrid, Spain.
authors: Alejandro
authors: A
authors: Brun
authors: The Jenner Institute, University of Oxford, Oxford, UK.
authors: Sarah C
authors: SC
authors: Gilbert
authors: International Livestock Research Institute (ILRI), Nairobi, Kenya.
authors: Vishvanath
authors: V
authors: Nene
authors: The Jenner Institute, University of Oxford, Oxford, UK.
authors: Adrian V S
authors: AV
authors: Hill
mesh_terms: D062705:Adenovirus Vaccines / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D057134:Antibodies, Neutralizing / Q000378:metabolism*; D002162:Camelus; D002417:Cattle; D006041:Goats; D006801:Humans; D002679:Pan troglodytes / Q000276:immunology / Q000821:virology; D012295:Rift Valley Fever / Q000276:immunology / Q000517:prevention & control*; D012296:Rift Valley fever virus / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D012529:Saudi Arabia / Q000453:epidemiology; D012756:Sheep; D006113:United Kingdom / Q000453:epidemiology; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000008:administration & dosage; D014759:Viral Envelope Proteins / Q000235:genetics* / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D062705:Adenovirus Vaccines; D057134:Antibodies, Neutralizing; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; D014765:Viral Vaccines