title: Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer.
abstract: Cancer cells in G0/G1 are resistant to cytotoxic chemotherapy agents which kill only cycling cancer cells. Salmonella typhimurium A1-R (S. typhimurium A1-R) decoyed cancer cells in monolayer culture and in tumor spheres to cycle from G0/G1 to S/G2/M, as demonstrated by fluorescence ubiquitination-based cell cycle indicator (FUCCI) imaging. S. typhimurium A1-R targeted FUCCI-expressing subcutaneous tumors, and tumors growing on the liver, growing in nude mice and also decoyed quiescent cancer cells, which were the majority of the cells in the tumors, to cycle from G0/G1 to S/G2/M. The S. typhimurium A1-R-decoyed cancer cells became sensitive to cytotoxic agents.
authors: AntiCancer Inc., and Department of Surgery, University of California, San Diego, CA, USA. all@anticancer.com.
authors: Robert M
authors: RM
authors: Hoffman
authors: AntiCancer Inc., and Department of Surgery, University of California, San Diego, CA, USA. all@anticancer.com.
authors: Shuya
authors: S
authors: Yano
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D015870:Gene Expression; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D012486:Salmonella typhimurium / Q000235:genetics* / Q000378:metabolism*; D019076:Transgenes; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents
keywords: Amino acid; Auxotroph; Cancer; Cell cycle; Chemotherapy; Decoy; Fluorescence ubiquitination-based cell cycle indicator (FUCCI); Green fluorescent protein (GFP)Red fluorescent protein (RFP); Imaging; Metastasis; Mouse models; Nude mice; Salmonella typhimurium A1-R; Surgical orthotopic implantation (SOI); Tumor-targeting