title: Baclofen differentially mediates fructose-conditioned flavor preference and quinine-conditioned flavor avoidance in rats.
abstract: Rats display both fructose-conditioned flavor preference (CFP) and quinine conditioned flavor avoidance (CFA). Dopamine (D1 and D2), muscarinic and nicotinic, but not NMDA or opioid receptor antagonists reduced fructose-CFP expression. Dopamine D1, dopamine D2, muscarinic or NMDA, but not opioid or nicotinic receptor antagonists reduced fructose-CFP acquisition. Dopamine D1, NMDA, nicotinic or opioid, but not dopamine D2 or muscarinic receptor antagonists enhanced quinine-CFA acquisition. Baclofen (BAC), a GABAB receptor agonist, alternately enhances or reduces feeding under specific conditions. The present study examined whether systemic BAC administration mediated fructose-CFP expression and acquisition or quinine-CFA acquisition. Fructose-CFP expression studies trained rats with one flavor (CS+) in 8% fructose and 0.2% saccharin and a second (CS-) flavor in 0.2% saccharin, followed by vehicle (VEH) and BAC (0.5-5 mg/kg) preceding 2-bottle (CS+, CS-) 0.2% saccharin choice tests. Fructose-CFP acquisition studies administered VEH or BAC (3 or 5 mg/kg) prior to CS+ and CS- training sessions followed by six 2-bottle (CS+, CS-) 0.2% saccharin choice tests. Quinine-CFA acquisition studies administered VEH or BAC (3 or 5 mg/kg) prior to CS- (8% fructose+0.2% saccharin) and CS+ (fructose+saccharin+0.030% quinine) training sessions followed by six 2-bottle (CS-, CS+) fructose+saccharin choice tests. BAC (3 mg/kg) minimally (66%) reduced fructose-CFP expression. BAC failed to alter fructose-CFP acquisition. Quinine-CFA acquisition was enhanced by the 5 mg/kg BAC dose (15-25%) relative to VEH (34-48%). These data implicate GABAB receptor signaling in acquisition of quinine avoidance with minimal or no effects upon fructose preferences.
authors: Behavioral and Cognitive Neuroscience Cluster, Psychology Doctoral Program, The Graduate Center, United States.
authors: Francis M
authors: FM
authors: Rotella
authors: Department of Psychology, Queens College, City University of New York, NY, NY, United States.
authors: Vishal
authors: V
authors: Vig
authors: Department of Psychology, Queens College, City University of New York, NY, NY, United States.
authors: Kerstin
authors: K
authors: Olsson
authors: Department of Psychology, Queens College, City University of New York, NY, NY, United States.
authors: Jeremy
authors: J
authors: Pagirsky
authors: Department of Psychology, Queens College, City University of New York, NY, NY, United States.
authors: Alon
authors: A
authors: Aminov
authors: Department of Psychology, Queens College, City University of New York, NY, NY, United States.
authors: Ilanna
authors: I
authors: Kohen
authors: Behavioral and Cognitive Neuroscience Cluster, Psychology Doctoral Program, The Graduate Center, United States; Department of Psychology, Queens College, City University of New York, NY, NY, United States. Electronic address: richard.bodnar@qc.cuny.edu.
authors: Richard J
authors: RJ
authors: Bodnar
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001418:Baclofen / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D005632:Fructose; D058786:GABA-B Receptor Agonists / Q000494:pharmacology*; D008297:Male; D011803:Quinine; D017207:Rats, Sprague-Dawley; D012439:Saccharin; D013649:Taste
chemical_list: D058786:GABA-B Receptor Agonists; D005632:Fructose; D011803:Quinine; D012439:Saccharin; D001418:Baclofen
keywords: Conditioning; GABA(B) receptor; Learning