title: Resistin: New serum marker for predicting severity of acute pancreatitis.
abstract: OBJECTIVE
  To assess the effectiveness of resistin in predicting the severity of acute pancreatitis.
  
  
  METHODS
  Patients with acute pancreatitis who presented at the Gastroenterology Clinic, Erzurum Education and Research Hospital, Turkey were enrolled in this prospective study. White blood cell (WBC), C-reactive protein (CRP) and resistin levels were measured on admission and at 24 h, day 3 and day 7 following admission, along with other blood parameters. Patients were divided into two groups: mild acute pancreatitis and moderate/severe acute pancreatitis.
  
  
  RESULTS
  Of 59 patients with acute pancreatitis (mild, n = 37; moderate/severe, n = 22), significant between-group differences were found in terms of resistin and CRP levels. Receiver operating curve analysis showed that resistin levels were better for predicting severe cases of acute pancreatitis than CRP or WBC levels on day 3 (area under the curve [AUC], 0.88 versus 0.81 and 0.63, respectively). Resistin levels on day 3 were better than CRP levels for predicting necrosis development (AUC, 0.70 versus 0.69, respectively).
  
  
  CONCLUSIONS
  Resistin may represent a new, effective indicator to predict the severity of acute pancreatitis and presence of necrosis in patients with acute pancreatitis.
authors: Department of Internal Medicine, Education and Research Hospital, Erzurum, Turkey.
authors: Yunus I
authors: YI
authors: Kibar
authors: Department of Internal Medicine, Section of Gastroenterology, Ataturk University Faculty of Medicine, Erzurum, Turkey.
authors: Fatih
authors: F
authors: Albayrak
authors: Department of Internal Medicine, Education and Research Hospital, Erzurum, Turkey.
authors: Mahmut
authors: M
authors: Arabul
authors: Department of Internal Medicine, Section of Gastroenterology, Ataturk University Faculty of Medicine, Erzurum, Turkey hadursun@hotmail.com.
authors: Hakan
authors: H
authors: Dursun
authors: Department of Surgery, Education and Research Hospital, Erzurum, Turkey.
authors: Yavuz
authors: Y
authors: Albayrak
authors: Department of Internal Medicine, Education and Research Hospital, Erzurum, Turkey.
authors: Yasin
authors: Y
authors: Ozturk
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D052243:Resistin / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; C499624:RETN protein, human; D052243:Resistin; D002097:C-Reactive Protein
keywords: C-reactive protein (CRP); Resistin; acute pancreatitis; predictive factor