title: Associations between a fatty acid desaturase gene polymorphism and blood arachidonic acid compositions in Japanese elderly.
abstract: We investigated whether the single nucleotide polymorphism rs174547 (T/C) of the fatty acid desaturase-1 gene, FADS1, is associated with changes in erythrocyte membrane and plasma phospholipid (PL) long-chain polyunsaturated fatty acid (LCPUFA) composition in elderly Japanese participants (n=124; 65 years or older; self-feeding and oral intake). The rs174547 C-allele carriers had significantly lower arachidonic acid (ARA; n-6 PUFA) and higher linoleic acid (LA, n-6 PUFA precursor) levels in erythrocyte membrane and plasma PL (15% and 6% ARA reduction, respectively, per C-allele), suggesting a low LA to ARA conversion rate in erythrocyte membrane and plasma PL of C-allele carriers. α-linolenic acid (n-3 PUFA precursor) levels were higher in the plasma PL of C-allele carriers, whereas levels of the n-3 LCPUFAs eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) were unchanged in erythrocyte membrane and plasma PL. Thus, rs174547 genotypes were significantly associated with different ARA compositions of the blood of elderly Japanese.
authors: Kagawa Nutrition University, Japan. Electronic address: hsa101@eiyo.ac.jp.
authors: Sayaka
authors: S
authors: Horiguchi
authors: Jichi Medical University, Japan.
authors: Kazuhiro
authors: K
authors: Nakayama
authors: Jichi Medical University, Japan.
authors: Sadahiko
authors: S
authors: Iwamoto
authors: Mamie Hospital, Japan.
authors: Akiko
authors: A
authors: Ishijima
authors: Mamie Hospital, Japan.
authors: Takayuki
authors: T
authors: Minezaki
authors: Mamie Hospital, Japan.
authors: Mamiko
authors: M
authors: Baba
authors: Niigata Prefecture University, Japan.
authors: Yoshiko
authors: Y
authors: Kontai
authors: Suntory Wellness Ltd., Japan.
authors: Chika
authors: C
authors: Horikawa
authors: Suntory Wellness Ltd., Japan.
authors: Hiroshi
authors: H
authors: Kawashima
authors: Suntory Wellness Ltd., Japan.
authors: Hiroshi
authors: H
authors: Shibata
authors: Kagawa Nutrition University, Japan.
authors: Yasuo
authors: Y
authors: Kagawa
authors: Kagawa Nutrition University, Japan.
authors: Terue
authors: T
authors: Kawabata
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016718:Arachidonic Acid / Q000097:blood*; D044466:Asian People; D000090943:Delta-5 Fatty Acid Desaturase; D004281:Docosahexaenoic Acids / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood; D044943:Fatty Acid Desaturases / Q000235:genetics*; D015525:Fatty Acids, Omega-3 / Q000097:blood; D005260:Female; D006801:Humans; D019787:Linoleic Acid / Q000097:blood; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017962:alpha-Linolenic Acid / Q000097:blood
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; D015525:Fatty Acids, Omega-3; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D019787:Linoleic Acid; D015118:Eicosapentaenoic Acid; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human
keywords: Arachidonic acid synthesis; Fatty acid desaturase; Single nucleotide polymorphism