title: Relationship of N-Terminal fragment of Pro-B-Type Natriuretic Peptide and copeptin with erythrocytes-related parameters: A population-based study.
abstract: BACKGROUND
  Plasma levels of natriuretic peptides (NP) have been inversely related to hemoglobin (Hb) concentration in prior studies. However, the mechanism underlying this association remains unclear. We aimed to obtain further insights into potential mechanisms for this correlation in a cohort of healthy adults.
  
  
  METHODS
  A population-based study was performed among 2113 healthy adults aged 25-41years. Relationships of N-Terminal fragment of Pro-B-Type Natriuretic Peptide (NT-proBNP) or copeptin with volume-dependent (Hb, hematocrit (Hct), erythrocyte count (EC), mean corpuscular Hb concentration (MCHC)) and volume-independent (mean corpuscular volume (MCV), mean corpuscular Hb (MCH)) erythrocyte-related parameters were assessed using sex-specific multivariable linear regression analyses.
  
  
  RESULTS
  The median age was 36.7years. Median NT-proBNP (ng/L) levels were 49.5 and 20 among women and men, respectively (p<0.0001). Mean (standard deviation) Hb (g/L) levels were 130.1(9.1) and 149.7(8.6) among women and men, respectively (p<0.0001). Among men, multivariable adjusted β-coefficients (95% confidence interval) for NT-proBNP were -1.68 (-2.36; -1.01), p<0.0001 for Hb; -0.38 (-0.57; -0.20), p<0.0001 for Hct; -0.06 (-0.09; -0.04), p<0.0001 for EC; -0.78 (-1.50; -0.07), p=0.03 for MCHC; 0.26 (-0.04; 0.56), p=0.09 for MCV; and 0.03 (-0.08; 0.14), p=0.61 for MCH. For copeptin, these relationships were 1.36 (0.39; 2.32), p=0.006; 0.41 (0.15; 0.68), p=0.002; 0.06 (0.02; 0.09), p=0.002; -0.17 (-1.19; 0.86), p=0.75; -0.12 (-0.55; 0.31), p=0.58 and -0.05 (-0.21; 0.10), p=0.52. Similar results were observed among women.
  
  
  CONCLUSIONS
  We found significant relationships of NT-proBNP and copeptin with volume-dependent but not volume-independent erythrocyte-related parameters, suggesting that hemodilution may at least in part explain these associations.
authors: Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
authors: Francisco Javier
authors: FJ
authors: Ruperti Repilado
authors: Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
authors: Stefanie
authors: S
authors: Aeschbacher
authors: Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
authors: Matthias
authors: M
authors: Bossard
authors: Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
authors: Tobias
authors: T
authors: Schoen
authors: Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
authors: Rebecca
authors: R
authors: Gugganig
authors: Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
authors: Jan Gerrit
authors: JG
authors: van der Stouwe
authors: Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
authors: Philipp
authors: P
authors: Krisai
authors: Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
authors: Thomas
authors: T
authors: Kofler
authors: Hematology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
authors: Andreas
authors: A
authors: Buser
authors: Labormedizinisches Zentrum Dr. Risch, Schaan, FL, Liechtenstein; Division of Laboratory Medicine, Kantonsspital Graubünden, Chur, Switzerland.
authors: Martin
authors: M
authors: Risch
authors: Labormedizinisches Zentrum Dr. Risch, Schaan, FL, Liechtenstein; Division of Clinical Biochemistry, Medical University Innsbruck, Innsbruck, Austria; UFL Private University, Fürstentum, Liechtenstein.
authors: Lorenz
authors: L
authors: Risch
authors: Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
authors: Christian
authors: C
authors: Mueller
authors: Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. Electronic address: david.conen@usb.ch.
authors: David
authors: D
authors: Conen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006020:Glycopeptides / Q000097:blood*; D006333:Heart Failure / Q000097:blood / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D013557:Switzerland / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; D010446:Peptide Fragments; C048197:copeptins; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Copeptin; Epidemiology; Hemodilution; Hemoglobin; Natriuretic peptides; Population-based