title: Impact of single-walled carbon nanotubes on the embryo: a brief review.
abstract: Carbon nanotubes (CNTs) are considered one of the most interesting materials in the 21st century due to their unique physiochemical characteristics and applicability to various industrial products and medical applications. However, in the last few years, questions have been raised regarding the potential toxicity of CNTs to humans and the environment; it is believed that the physiochemical characteristics of these materials are key determinants of CNT interaction with living cells and hence determine their toxicity in humans and other organisms as well as their embryos. Thus, several recent studies, including ours, pointed out that CNTs have cytotoxic effects on human and animal cells, which occur via the alteration of key regulator genes of cell proliferation, apoptosis, survival, cell-cell adhesion, and angiogenesis. Meanwhile, few investigations revealed that CNTs could also be harmful to the normal development of the embryo. In this review, we will discuss the toxic role of single-walled CNTs in the embryo, which was recently explored by several groups including ours.
authors: College of Medicine & Biomedical Research Centre, Qatar University, Doha, Qatar; Oncology Department, McGill University, Montreal, QC, Canada; Mechanical and Industrial Engineering Department, Concordia University, Montreal, QC, Canada; Syrian Research Cancer Centre of the Syrian Society against Cancer, Aleppo, Syria.
authors: Ala-Eddin
authors: AE
authors: Al Moustafa
authors: Nova Scotia Community College, Dartmouth, NS, Canada.
authors: Etienne
authors: E
authors: Mfoumou
authors: Mechanical and Industrial Engineering Department, Concordia University, Montreal, QC, Canada.
authors: Dacian E
authors: DE
authors: Roman
authors: École de Technologie Supérieure, Montreal, QC, Canada.
authors: Vahe
authors: V
authors: Nerguizian
authors: Department of Mechanical Engineering, Khalifa University, Abu Dhabi, UAE.
authors: Anas
authors: A
authors: Alazzam
authors: Mechanical and Industrial Engineering Department, Concordia University, Montreal, QC, Canada.
authors: Ion
authors: I
authors: Stiharu
authors: Segal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, Canada.
authors: Amber
authors: A
authors: Yasmeen
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects / Q000473:pathology*; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D037742:Nanotubes, Carbon / Q000009:adverse effects* / Q000737:chemistry; D018675:Toxicity Tests
chemical_list: D037742:Nanotubes, Carbon
keywords: embryo; single-walled carbon nanotubes; toxicity