title: Extended Ciprofloxacin Release Using Vitamin E Diffusion Barrier From Commercial Silicone-Based Soft Contact Lenses.
abstract: OBJECTIVE
  Ciprofloxacin (Cipro) is an antibiotic, widely used in form of ophthalmic drops (0.3%) for the treatment of eye infections. In this study, vitamin E was used as a hydrophobic barrier to improve and prolong the amount and time of Cipro release from silicone-based soft contact lenses.
  
  
  METHODS
  Three different commercial contact lenses (Air Optix, Biofinity, and Acuvue Oasys) were soaked in vitamin E solutions (0.1 and 0.2 g/mL). The effect of vitamin E on Cipro loading amount and drug releasing profile was evaluated in artificial tear. Swelling properties and diameter changes of the lenses were also investigated in aqueous media in presence and absence of vitamin E.
  
  
  RESULTS
  The data indicated that vitamin E, as a hydrophobic barrier, significantly decreased the water content of silicone-based soft contact lenses. After vitamin E loading, a 5% to 18% increase was observed in lens diameter in the hydrated state, whereas the lens diameter increased by 11% to 23% in the dry state. In all commercial lenses, vitamin E loading in a 0.2-g/mL solution caused a 27.94% to 37.08% increase in Cipro binding. The results indicated that applying vitamin E loading solutions, with 0.1 and 0.2 g/mL concentrations, could effectively enhance Cipro release time from 2 hr (in a pure non-vitamin E-loaded lens) to 14 to 17 and 30 to 33 days, respectively. These values showed an increase by a factor of 168 to 204 and 360 to 396 in Cipro release time after using vitamin E loading solutions with 0.1 and 0.2 g/mL concentrations, respectively, compared with pure non-vitamin E-loaded soft contact lenses.
  
  
  CONCLUSIONS
  This study indicated that vitamin E acts as an effective hydrophobic barrier, in increasing the Cipro loading capacity of silicone-based contact lenses and prolonging the drug release into the artificial tear.
authors: Student Research Committee (SRC) (M.S.R.), Mashhad University of Medical Sciences, Mashhad, Iran; and Pharmaceutical Research Center (M.S.R., S.A.M.), School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Maryam
authors: M
authors: Shayani Rad
authors: Seyed Ahmad
authors: SA
authors: Mohajeri
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002939:Ciprofloxacin / Q000008:administration & dosage*; D003263:Contact Lenses, Hydrophilic; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000737:chemistry; D012826:Silicone Elastomers / Q000737:chemistry*; D014810:Vitamin E / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D009883:Ophthalmic Solutions; D012826:Silicone Elastomers; D014815:Vitamins; D014810:Vitamin E; D002939:Ciprofloxacin