title: Improvement of Pharmaceutical Properties of Isoprenoid Compounds through the Formation of Cyclodextrin Pseudorotaxane-Like Supramolecules.
abstract: The purpose of this study was to design cyclodextrin (CyD)-based pseudorotaxane-like supramolecular complexes with various isoprenoid compounds, such as reduced coenzyme Q10 (R-CoQ10), squalene, tocotrienol, and teprenone, and to evaluate their pharmaceutical properties. Squalene, tocotrienol, and teprenone formed precipitates with β-CyD and γ-CyD in aqueous solution, whereas R-CoQ10 formed precipitates with γ-CyD aqueous solution. The results of powder X-ray diffraction and (1)H-NMR analyses indicated that these precipitates are derived from pseudorotaxane-like supramolecular complexes. The photostability of teprenone was markedly improved by complexation with CyDs, especially in the γ-CyD system. In addition, the dispersion rates of teprenone in the γ-CyD system were higher than those in the β-CyD system, compared with the corresponding physical mixtures. In conclusion, pharmaceutical properties such as photostability and dispersion rates of isoprenoid compounds were improved by the formation of pseudorotaxane-like supramolecular complexes with β-CyD and/or γ-CyD.
authors: Graduate School of Pharmaceutical Sciences, Kumamoto University.
authors: Taishi
authors: T
authors: Higashi
authors: Haruki
authors: H
authors: Tanaka
authors: Ayumi
authors: A
authors: Yoshimatsu
authors: Haruna
authors: H
authors: Ikeda
authors: Kanako
authors: K
authors: Arima
authors: Masatoshi
authors: M
authors: Honjo
authors: Chihiro
authors: C
authors: Iwamoto
authors: Keiichi
authors: K
authors: Motoyama
authors: Hidetoshi
authors: H
authors: Arima
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D033362:Powder Diffraction; D066244:Proton Magnetic Resonance Spectroscopy; D043862:Rotaxanes / Q000737:chemistry*; D013729:Terpenes / Q000494:pharmacology*; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D043862:Rotaxanes; D013729:Terpenes; D014451:Ubiquinone; C024989:coenzyme Q10