title: Do Symptoms among Home Palliative Care Patients with Advanced Cancer Decide the Place of Death? Focusing on the Presence or Absence of Symptoms during Home Care.
abstract: Our goal was to investigate the association between actual place of death among Japanese home end-of-life care patients with advanced cancer and individual, illness, and environmental factors, including the presence or absence of symptoms.
  
  
  
  Using structured interviews, we asked 44 nurses from 19 home-visit nursing agencies about changes in status of all 123 of their home end-of-life care patients with advanced cancer between April and September 2013. The main outcome variable was actual place of death (Home/Hospital/Still surviving) and independent variables were the patient's symptoms as a time-dependent variable. Competing risk analysis was conducted with adjustment for patient individual factors (demographics, medical factors, caregiver support, and patient's and caregiver's preference for place of death) and environmental factors (availability of physician-visit and policy at discharge).
  
  
  
  Among all patients, 53 died in the hospital, 52 at home, and 16 still survived. Multivariate analyses revealed the following: 1) patients were more likely to die in the hospital when pain and dyspnea were present (adjusted sub hazard ratio [SHR]: 1.50 [95% confidence interval (CI): 1.23-1.83] and 1.71 [95% CI: 1.36-2.15], respectively); 2) patients were less likely to die in the hospital when delirium was present (adjusted SHR: 0.64 [95%CI: 0.43-0.96]); and 3) other factors associated with hospital death were patient's gender, primary cancer site, caregiver support, health care service, policy at discharge, and congruence between the patient's and family's preference for place of death.
  
  
  
  To alleviate pain and dyspnea among home end-of-life care patients, development of both a rapid admission system to a hospital/hospice/care facility in the community and specialist-level palliative care at home is needed.
authors: 1 Department of Community Health Nursing, Graduate School of Nursing, Japanese Red Cross University , Tokyo, Japan .
authors: Yuko
authors: Y
authors: Okamoto
authors: 1 Department of Community Health Nursing, Graduate School of Nursing, Japanese Red Cross University , Tokyo, Japan .
authors: Sakiko
authors: S
authors: Fukui
authors: 2 Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan .
authors: Kazuhiro
authors: K
authors: Yoshiuchi
authors: 1 Department of Community Health Nursing, Graduate School of Nursing, Japanese Red Cross University , Tokyo, Japan .
authors: Takako
authors: T
authors: Ishikawa
mesh_terms: D003643:Death; D006699:Home Care Services; D017051:Hospice Care; D006801:Humans; D009369:Neoplasms; D010166:Palliative Care