title: A three-component reagent system for rapid and mild removal of O-, N- and S-trityl protecting groups.
abstract: A new reagent system consisting of a Lewis acid such as BF3·Et2O or Cu(OTf)2, the mild protic acid hexafluoroisopropanol and the reducing quenching agent triethylsilane was elaborated for O-, N- and S-detritylation of nucleoside, carbohydrate and amino acid derivatives. The method is compatible with acetyl, silyl, acetal and Fmoc groups.
authors: Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary. borbas.aniko@pharm.unideb.hu herczeghp@gmail.com.
authors: Máté
authors: M
authors: Kicsák
authors: Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary. borbas.aniko@pharm.unideb.hu herczeghp@gmail.com.
authors: Miklós
authors: M
authors: Bege
authors: Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary. borbas.aniko@pharm.unideb.hu herczeghp@gmail.com.
authors: Ilona
authors: I
authors: Bereczki
authors: Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary. borbas.aniko@pharm.unideb.hu herczeghp@gmail.com.
authors: Magdolna
authors: M
authors: Csávás
authors: Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary. borbas.aniko@pharm.unideb.hu herczeghp@gmail.com.
authors: Mihály
authors: M
authors: Herczeg
authors: Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
authors: Zoltán
authors: Z
authors: Kupihár
authors: Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
authors: Lajos
authors: L
authors: Kovács
authors: Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary. borbas.aniko@pharm.unideb.hu herczeghp@gmail.com.
authors: Anikó
authors: A
authors: Borbás
authors: Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary. borbas.aniko@pharm.unideb.hu herczeghp@gmail.com.
authors: Pál
authors: P
authors: Herczegh