title: Cancer among patients with type 2 diabetes mellitus: A population-based cohort study in northeastern Italy.
abstract: Diabetes mellitus (DM) is associated with an elevated risk of cancer. The aim of this study was to assess cancer risk and survival in individuals with type 2 DM (T2DM) in Friuli Venezia Giulia, Italy. A retrospective population-based cohort study of 32,247 T2DM patients aged 40-84 years was conducted through a record linkage of local healthcare databases and cancer registry for the period 2002-2009. Standardized incidence ratios (SIRs) with 95% confidence intervals (95%CIs) and 5-year survival probabilities after T2DM and cancer diagnosis were computed. The SIRs for all cancers (n=2069) was 1.28 (95%CI: 1.23-1.34). The highest SIRs were observed for cancers of the liver, female genital organs, small intestine, and pancreas. After 3 years from T2DM diagnosis, a reduced risk of prostate cancer (SIR=0.73, 95%CI: 0.54-0.96) was found in men aged 65-74 years, and a higher risk for breast cancer (SIR=1.24, 95%CI: 1.00-1.52) was found among T2DM female patients. The overall 5-year survival after T2DM was 88.7%. Furthermore, T2DM appeared to have a negative effect on survival of women with breast cancer. This population-based study confirmed that T2DM patients are at increased risk of several cancers, and of premature death in women with breast cancer.
authors: Epidemiology and Biostatistics Unit, IRCCS CRO National Cancer Institute, Aviano, Italy. Electronic address: epidemiology@cro.it.
authors: Andrea
authors: A
authors: Gini
authors: Epidemiology and Biostatistics Unit, IRCCS CRO National Cancer Institute, Aviano, Italy.
authors: Ettore
authors: E
authors: Bidoli
authors: Friuli Venezia Giulia Central Health Direction, Udine, Italy.
authors: Loris
authors: L
authors: Zanier
authors: Friuli Venezia Giulia Central Health Direction, Udine, Italy.
authors: Elena
authors: E
authors: Clagnan
authors: Diabetology Unit, Santa Maria degli Angeli Hospital, Pordenone, Italy.
authors: Giorgio
authors: G
authors: Zanette
authors: Friuli Venezia Giulia Central Health Direction, Udine, Italy.
authors: Michele
authors: M
authors: Gobbato
authors: Scientific Directorate, IRCCS CRO National Cancer Institute, Aviano, Italy.
authors: Paolo
authors: P
authors: De Paoli
authors: Epidemiology and Biostatistics Unit, IRCCS CRO National Cancer Institute, Aviano, Italy.
authors: Diego
authors: D
authors: Serraino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Cancer; Cancer risk; Population-based cohort study; Record linkage; Survival; Type 2 diabetes mellitus