title: Postoperative complications in the treatment of rectal neoplasia by transanal endoscopic microsurgery: a prospective study of risk factors and time course.
abstract: OBJECTIVE
  Transanal endoscopic microsurgery (TEM) is a safe and efficient minimally invasive treatment for rectal benign and early malignant neoplasia, but postoperative complications may be severe. We aimed to evaluate the risk factors related to the incidence, severity, and time course of postoperative complications of TEM.
  
  
  METHODS
  This is a prospective study of postoperative complications in 53 patients (>18 years old) with benign or early rectal neoplasia who underwent TEM with curative intention or, for higher stages, palliation. Outcome measures included age, sex, American Society of Anesthesiologists score, neoadjuvant chemoradiotherapy, lesion height and size, pathologic margins, tumor histology, and suture type.
  
  
  RESULTS
  Overall morbidity was 50 %. Temporary fecal incontinence was the most frequent complication (17.3 %). Complication rates of Clavien-Dindo grades I and II were 21.1 % and those of grades III and IV 3.8 %. Of patients with complications, more had lesions under the first rectal valve than over the first valve (61.54 % vs 38.46 %, p = 0.04). Patients submitted to chemoradiotherapy had a 24-fold greater chance of presenting grade II complications (p = 0.002). When the surgical defect was treated using the TEM device to perform the suture, the chance of having grade III complications was reduced 16-fold (p = 0.04). Fifty-three percent of complications occurred in the first 10 days and 95 % within 20 days.
  
  
  CONCLUSIONS
  Postoperative complications after transanal endoscopic microsurgery for the treatment of rectal neoplasia are frequent, acceptable, and usually controllable with pharmacologic treatment. Over time the nature of complications is continuous, centered on the first 20 days after surgery.
authors: Digestive Surgery, Gastroenterology Department, Hospital das Clinicas/Cancer Institute University of São Paulo Medical School, Rua Dona Adma Jafet, 74, cj172-174, Bela Vista, São Paulo, SP, 01308-050, Brazil. sparapanmarques@gmail.com.
authors: Carlos Frederico S
authors: CF
authors: Marques
authors: Digestive Surgery, Gastroenterology Department, Hospital das Clinicas/Cancer Institute University of São Paulo Medical School, Rua Dona Adma Jafet, 74, cj172-174, Bela Vista, São Paulo, SP, 01308-050, Brazil.
authors: Caio Sergio R
authors: CS
authors: Nahas
authors: Digestive Surgery, Gastroenterology Department, Hospital das Clinicas/Cancer Institute University of São Paulo Medical School, Rua Dona Adma Jafet, 74, cj172-174, Bela Vista, São Paulo, SP, 01308-050, Brazil.
authors: Ulysses
authors: U
authors: Ribeiro
authors: Digestive Surgery, Gastroenterology Department, Hospital das Clinicas/Cancer Institute University of São Paulo Medical School, Rua Dona Adma Jafet, 74, cj172-174, Bela Vista, São Paulo, SP, 01308-050, Brazil.
authors: Leonardo A
authors: LA
authors: Bustamante
authors: Digestive Surgery, Gastroenterology Department, Hospital das Clinicas/Cancer Institute University of São Paulo Medical School, Rua Dona Adma Jafet, 74, cj172-174, Bela Vista, São Paulo, SP, 01308-050, Brazil.
authors: Rodrigo Ambar
authors: RA
authors: Pinto
authors: Digestive Surgery, Gastroenterology Department, Hospital das Clinicas/Cancer Institute University of São Paulo Medical School, Rua Dona Adma Jafet, 74, cj172-174, Bela Vista, São Paulo, SP, 01308-050, Brazil.
authors: Eduardo Kenzo
authors: EK
authors: Mory
authors: Digestive Surgery, Gastroenterology Department, Hospital das Clinicas/Cancer Institute University of São Paulo Medical School, Rua Dona Adma Jafet, 74, cj172-174, Bela Vista, São Paulo, SP, 01308-050, Brazil.
authors: Ivan
authors: I
authors: Cecconello
authors: Digestive Surgery, Gastroenterology Department, Hospital das Clinicas/Cancer Institute University of São Paulo Medical School, Rua Dona Adma Jafet, 74, cj172-174, Bela Vista, São Paulo, SP, 01308-050, Brazil.
authors: Sergio Carlos
authors: SC
authors: Nahas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy; D003710:Demography; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011183:Postoperative Complications / Q000209:etiology*; D011336:Probability; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000601:surgery*; D012307:Risk Factors; D013997:Time Factors; D000067369:Transanal Endoscopic Microsurgery / Q000009:adverse effects*
keywords: Minimally invasive surgery; Organ-sparing treatment; Postoperative complications; Risk factors; Transanal endoscopic microsurgery