title: Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease.
abstract: The objective of this study was to determine the utility of subjective memory decline (SMD) to predict episodic memory change and rates of clinical progression in cognitively normal older adults with evidence of high β-amyloid burden (CN Aβ+).
  
  
  
  Fifty-eight CN Aβ+ participants from the Australian Imaging, Biomarkers, and Lifestyle study responded to an SMD questionnaire and underwent comprehensive neuropsychological assessments. Participant data for three follow-up assessments were analyzed.
  
  
  
  In CN Aβ+, subjects with high SMD did not exhibit significantly greater episodic memory decline than those with low SMD. High SMD was related to greater rates of progression to mild cognitive impairment or Alzheimer's disease (AD) dementia (hazard ratio = 5.1; 95% confidence interval, 1.4-20.0, P = .02) compared with low SMD. High SMD was associated with greater depressive symptomatology and smaller left hippocampal volume.
  
  
  
  High SMD is a harbinger of greater rates of clinical progression in preclinical AD. Although SMD reflects broader diagnostic implications for CN Aβ+, more sensitive measures may be required to detect early subtle cognitive change.
authors: Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia. Electronic address: rachel.buckley@unimelb.edu.au.
authors: Rachel F
authors: RF
authors: Buckley
authors: Cogstate Ltd, Melbourne, Australia.
authors: Paul
authors: P
authors: Maruff
authors: The Academic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, University of Melbourne.
authors: David
authors: D
authors: Ames
authors: The Australian eHealth Research Centre, CSIRO Health & Biosecurity Flagship, QLD, Australia.
authors: Pierrick
authors: P
authors: Bourgeat
authors: Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, WA, Australia; School of Psychiatry and Clinical Neurosciences and West Australian Centre for Health & Ageing, University of Western Australia; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia.
authors: Ralph N
authors: RN
authors: Martins
authors: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
authors: Colin L
authors: CL
authors: Masters
authors: Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, WA, Australia; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia.
authors: Stephanie
authors: S
authors: Rainey-Smith
authors: The Academic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, University of Melbourne; School of Psychiatry and Clinical Neurosciences and West Australian Centre for Health & Ageing, University of Western Australia.
authors: Nicola
authors: N
authors: Lautenschlager
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia; Department of Medicine, Austin Health, University of Melbourne, Melbourne, Australia.
authors: Christopher C
authors: CC
authors: Rowe
authors: ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, Australia.
authors: Greg
authors: G
authors: Savage
authors: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia; Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia; Department of Medicine, Austin Health, University of Melbourne, Melbourne, Australia.
authors: Victor L
authors: VL
authors: Villemagne
authors: The Academic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, University of Melbourne.
authors: Kathryn A
authors: KA
authors: Ellis
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001315:Australia; D003072:Cognition Disorders / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D049268:Positron-Emission Tomography; D062706:Prodromal Symptoms; D011446:Prospective Studies
chemical_list: D016229:Amyloid beta-Peptides
keywords: Amyloid; PET imaging; Preclinical AD; Prodromal AD; Subjective cognitive decline; Subjective memory decline cognitively normal older adults