title: Six Versus 12 Months of Dual Antiplatelet Therapy After Implantation of Biodegradable Polymer Sirolimus-Eluting Stent: Randomized Substudy of the I-LOVE-IT 2 Trial.
abstract: BACKGROUND
  There are no reports on a large-scale randomized trial exploring optimal dual antiplatelet therapy (DAPT) duration after biodegradable polymer sirolimus-eluting stent implantation. We sought to report the outcomes of a randomized substudy of the prospective Evaluate Safety and Effectiveness of the Tivoli DES and the Firebird DES for Treatment of Coronary Revascularization (I-LOVE-IT 2) trial.
  
  
  RESULTS
  In the prospective noninferiority randomized I-LOVE-IT 2 trial, 1829 patients allocated to the biodegradable polymer sirolimus-eluting stent group were also randomized to receive either 6-month (n=909) or 12-month DAPT (n=920). The primary end points of this noninferiority substudy were 12-month target lesion failure (composite of cardiac death, target vessel myocardial infarction or clinically indicated target lesion revascularization), and the major secondary end points were 12-month net adverse clinical and cerebral events (composite of all-cause death, all myocardial infarction, stroke, or major bleeding [Bleeding Academic Research Consortium type ≥3]). The 12-month target lesion failure in 6-month DAPT group was comparable with the 12-month DAPT group (6.8% versus 5.9%; difference and 95% confidence interval, 0.87% [-1.37% to 3.11%], P for noninferiority=0.0065). Further follow-up at 18 months showed that incidence of target lesion failure and net adverse clinical and cerebral events were similar between the 2 groups (7.5% versus 6.3%, log-rank P=0.32; 7.8% versus 7.3%, log-rank P=0.60; respectively), as well as their individual end point components.
  
  
  CONCLUSIONS
  This study indicated noninferiority in safety and efficacy of 6-month versus 12-month DAPT after implantation of a novel biodegradable polymer sirolimus-eluting stent.
  
  
  BACKGROUND
  URL: http://www.clinicaltrials.gov. Unique identifier: NCT01681381.
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.). hanyalingnh@163.com.
authors: Yaling
authors: Y
authors: Han
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Bo
authors: B
authors: Xu
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Kai
authors: K
authors: Xu
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Changdong
authors: C
authors: Guan
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Quanmin
authors: Q
authors: Jing
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Qiangsun
authors: Q
authors: Zheng
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Xueqi
authors: X
authors: Li
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Xianxian
authors: X
authors: Zhao
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Haichang
authors: H
authors: Wang
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Xuezhong
authors: X
authors: Zhao
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Xiaoyan
authors: X
authors: Li
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Pengfei
authors: P
authors: Yu
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Hongyun
authors: H
authors: Zang
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Zhifang
authors: Z
authors: Wang
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Xuebin
authors: X
authors: Cao
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Jun
authors: J
authors: Zhang
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Wenyue
authors: W
authors: Pang
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Jing
authors: J
authors: Li
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: Yuejin
authors: Y
authors: Yang
authors: From the Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, China (Y.H., K.X., Q.J., J.L.); Catheterization Laboratory, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (B.X., C.G.); Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China (Y.Y.); Department of Cardiology, Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi'an, China (Q.Z.); Department of Cardiology, Fourth Affiliated Hospital of Haerbin Medical University, Haerbin, China (Xueqi Li); Department of Cardiology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai, China (Xianxian Zhao); Department of Cardiology, Affiliated Xijing Hospital of the Fourth Military Medical University, Xi'an, China (H.W.); Department of Cardiology, Jilin University First Hospital, Changchun, China (Xuezhong Zhao); Department of Cardiology, General Hospital of Jinan Military Region, Jinan, China (Xiaoyan Li); Department of Cardiology, Pingdu People's Hospital, Pingdu, China (P.Y.); Department of Cardiology, NO. 463 Hospital of PLA, Shenyang, China (H.Z.); Department of Cardiology, Xinxiang Central Hospital, Xinxiang, China (Z.W.); Department of Cardiology, NO. 252 Hospital of PLA, Baoding, China (X.C.); Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China (J.Z.); Department of Cardiology, Shengjing Hospital, Shenyang, China (W.P.); and The Zena and Michael A. Wiener Cardiovascular Institute, Interventional Cardiovascular Research and Clinical Trials Center, Mount Sinai Medical Center, New York (G.D.D.).
authors: George D
authors: GD
authors: Dangas
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage*; D000077144:Clopidogrel; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D011446:Prospective Studies; D020123:Sirolimus / Q000008:administration & dosage; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000903:Antibiotics, Antineoplastic; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin; D020123:Sirolimus
keywords: clinical trial; drug-eluting stents; hemorrhage; myocardial infarction; polymers