title: Branched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations.
abstract: Recent studies revealed strong evidence that branched-chain and aromatic amino acids (BCAAs and AAAs) are closely associated with the risk of developing type 2 diabetes in several Western countries. The aim of this study was to evaluate the potential role of BCAAs and AAAs in predicting the diabetes development in Chinese populations. The serum levels of valine, leucine, isoleucine, tyrosine, and phenylalanine were measured in a longitudinal and a cross sectional studies with a total of 429 Chinese participants at different stages of diabetes development, using an ultra-performance liquid chromatography triple quadruple mass spectrometry platform. The alterations of the five AAs in Chinese populations are well in accordance with previous reports. Early elevation of the five AAs and their combined score was closely associated with future development of diabetes, suggesting an important role of these metabolites as early markers of diabetes. On the other hand, the five AAs were not as good as existing clinical markers in differentiating diabetic patients from their healthy counterparts. Our findings verified the close correlation of BCAAs and AAAs with insulin resistance and future development of diabetes in Chinese populations and highlighted the predictive value of these markers for future development of diabetes.
authors: Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors: Tianlu
authors: T
authors: Chen
authors: University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
authors: Yan
authors: Y
authors: Ni
authors: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai, 200233, China.
authors: Xiaojing
authors: X
authors: Ma
authors: Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.|Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai, 200233, China.
authors: Yuqian
authors: Y
authors: Bao
authors: Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors: Jiajian
authors: J
authors: Liu
authors: Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors: Fengjie
authors: F
authors: Huang
authors: Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.|Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai, 200233, China.
authors: Cheng
authors: C
authors: Hu
authors: University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
authors: Guoxiang
authors: G
authors: Xie
authors: Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors: Aihua
authors: A
authors: Zhao
authors: Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.|Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai, 200233, China.
authors: Weiping
authors: W
authors: Jia
authors: Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.|University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
authors: Wei
authors: W
authors: Jia
mesh_terms: D000328:Adult; D000368:Aged; D024322:Amino Acids, Aromatic / Q000097:blood*; D000597:Amino Acids, Branched-Chain / Q000097:blood*; D002681:China; D002853:Chromatography, Liquid; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D007532:Isoleucine / Q000097:blood; D007930:Leucine / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D010649:Phenylalanine / Q000097:blood; D012307:Risk Factors; D014443:Tyrosine / Q000097:blood; D014633:Valine / Q000097:blood; D055815:Young Adult
chemical_list: D024322:Amino Acids, Aromatic; D000597:Amino Acids, Branched-Chain; D007532:Isoleucine; D014443:Tyrosine; D010649:Phenylalanine; D007930:Leucine; D014633:Valine