title: Prevalence of Urinary Tract Infection and Antimicrobial Susceptibility among Diabetic Patients with Controlled and Uncontrolled Glycemia in Kuwait.
abstract: Diabetic patients have higher risk of urinary tract infection (UTI). In the present study, we investigated the impact of glycemic control in diabetic patients on UTI prevalence, type of strains, and their antimicrobial drugs susceptibility. This study was conducted on urine samples from 722 adult diabetic patients from which 252 (35%) samples were positive for uropathogens. Most UTI cases occurred in the uncontrolled glycemic group (197 patients) versus 55 patients with controlled glycemia. Higher glycemic levels were measured in uncontrolled glycemia group (HbA1c = 8.3 ± 1.5 and 5.4 ± 0.4, resp., P < 0.0001). Females showed much higher prevalence of UTI than males in both glycemic groups (88.5% and 11.5%, resp., P < 0.0001). In the uncontrolled glycemia group 90.9% of the UTI cases happened at ages above 40 years and a clear correlation was obtained between patient age ranges and number of UTI cases (r = 0.94; P = 0.017), whereas in the group with controlled glycemia no trend was observed. Escherichia coli was the predominant uropathogen followed by Klebsiella pneumoniae and they were together involved in 76.2% of UTI cases. Those species were similarly present in both diabetic groups and displayed comparable antibiotic resistance pattern. These results highlight the importance of controlling glycemia in diabetic patients to reduce the UTI regardless of age and gender.
authors: Clinical Services Department, Dasman Diabetes Institute, P.O. Box 1180, 15462 Kuwait, Kuwait.
authors: May
authors: M
authors: Sewify
authors: Clinical Services Department, Dasman Diabetes Institute, P.O. Box 1180, 15462 Kuwait, Kuwait.
authors: Shinu
authors: S
authors: Nair
authors: Biochemistry & Molecular Biology Unit, Dasman Diabetes Institute, P.O. Box 1180, 15462 Kuwait, Kuwait.
authors: Samia
authors: S
authors: Warsame
authors: Clinical Services Department, Dasman Diabetes Institute, P.O. Box 1180, 15462 Kuwait, Kuwait.
authors: Mohamed
authors: M
authors: Murad
authors: Clinical Services Department, Dasman Diabetes Institute, P.O. Box 1180, 15462 Kuwait, Kuwait.
authors: Asma
authors: A
authors: Alhubail
authors: Clinical Services Department, Dasman Diabetes Institute, P.O. Box 1180, 15462 Kuwait, Kuwait; Biochemistry & Molecular Biology Unit, Dasman Diabetes Institute, P.O. Box 1180, 15462 Kuwait, Kuwait.
authors: Kazem
authors: K
authors: Behbehani
authors: Clinical Services Department, Dasman Diabetes Institute, P.O. Box 1180, 15462 Kuwait, Kuwait.
authors: Faisal
authors: F
authors: Al-Refaei
authors: Biochemistry & Molecular Biology Unit, Dasman Diabetes Institute, P.O. Box 1180, 15462 Kuwait, Kuwait.
authors: Ali
authors: A
authors: Tiss
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001786:Blood Glucose; D048909:Diabetes Complications / Q000382:microbiology*; D003920:Diabetes Mellitus / Q000382:microbiology*; D004926:Escherichia coli; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000382:microbiology*; D007711:Klebsiella pneumoniae; D007730:Kuwait / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015995:Prevalence; D012306:Risk; D016482:Urinalysis; D014552:Urinary Tract Infections / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D001786:Blood Glucose