title: Effect of Coronary Atherosclerosis and Myocardial Ischemia on Plasma Levels of High-Sensitivity Troponin T and NT-proBNP in Patients With Stable Angina.
abstract: OBJECTIVE
  Circulating levels of high-sensitivity cardiac troponin T (hs-cTnT) and N terminal pro brain natriuretic peptide (NT-proBNP) are predictors of prognosis in patients with coronary artery disease (CAD). We aimed at evaluating the effect of coronary atherosclerosis and myocardial ischemia on cardiac release of hs-cTnT and NT-proBNP in patients with suspected CAD.
  
  
  RESULTS
  Hs-cTnT and NT-proBNP were measured in 378 patients (60.1±0.5 years, 229 males) with stable angina and unknown CAD enrolled in the Evaluation of Integrated Cardiac Imaging (EVINCI) study. All patients underwent stress imaging to detect myocardial ischemia and coronary computed tomographic angiography to assess the presence and characteristics of CAD. An individual computed tomographic angiography score was calculated combining extent, severity, composition, and location of plaques. In the whole population, the median (25-75 percentiles) value of plasma hs-cTnT was 6.17 (4.2-9.1) ng/L and of NT-proBNP was 61.66 (31.2-132.6) ng/L. In a multivariate model, computed tomographic angiography score was an independent predictor of the plasma hs-cTnT (coefficient 0.06, SE 0.02; P=0.0089), whereas ischemia was a predictor of NT-proBNP (coefficient 0.38, SE 0.12; P=0.0015). Hs-cTnT concentrations were significantly increased in patients with CAD with or without myocardial ischemia (P<0.005), whereas only patients with CAD and ischemia showed significantly higher levels of NT-proBNP (P<0.001).
  
  
  CONCLUSIONS
  In patients with stable angina, the presence and extent of coronary atherosclerosis is related with circulating levels of hs-cTnT, also in the absence of ischemia, suggesting an ischemia-independent mechanism of hs-cTnT release. Obstructive CAD causing myocardial ischemia is associated with increased levels of NT-proBNP.
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.). chiara.caselli@ifc.cnr.it.
authors: Chiara
authors: C
authors: Caselli
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Concetta
authors: C
authors: Prontera
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Riccardo
authors: R
authors: Liga
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Michiel A
authors: MA
authors: De Graaf
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Oliver
authors: O
authors: Gaemperli
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Valentina
authors: V
authors: Lorenzoni
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Rosetta
authors: R
authors: Ragusa
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Martina
authors: M
authors: Marinelli
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Silvia
authors: S
authors: Del Ry
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Daniele
authors: D
authors: Rovai
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Daniela
authors: D
authors: Giannessi
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Santiago
authors: S
authors: Aguade-Bruix
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Alberto
authors: A
authors: Clemente
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Jeroen J
authors: JJ
authors: Bax
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Massimo
authors: M
authors: Lombardi
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Rosa
authors: R
authors: Sicari
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: José
authors: J
authors: Zamorano
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Arthur J
authors: AJ
authors: Scholte
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Philipp A
authors: PA
authors: Kaufmann
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Juhani
authors: J
authors: Knuuti
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: S Richard
authors: SR
authors: Underwood
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Aldo
authors: A
authors: Clerico
authors: From the CNR, Institute of Clinical Physiology, Pisa, Italy (C.C., M.M., S.D.R., D.R., D.G., R.S., D.N.); Fondazione Toscana G. Monasterio, Pisa, Italy (C.P., A.C., M.L., A.C., D.N.); Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Italy (R.L.); Leiden University Medical Center, Leiden, The Netherlands (M.A.D.G., J.J.B., A.J.S.); University Hospital Zurich, Zurich, Switzerland (O.G., P.A.K.); Scuola Superiore Sant'Anna, Pisa, Italy (V.L., R.R., A.C.); Hospital Universitario Vall d'Hebron, Barcelona, Spain (S.A.-B.); University Alcala, Hospital Ramón y Cajal, Madrid, Spain (J.Z.); University of Turku and Turku University Hospital, Turku, Finland (J.K.); and Imperial College London, United Kingdom (S.R.U.).
authors: Danilo
authors: D
authors: Neglia
mesh_terms: D060050:Angina, Stable / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D025401:Echocardiography, Stress; D005060:Europe; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000097:blood* / Q000175:diagnosis; D055414:Myocardial Perfusion Imaging; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C545568:TNNT2 protein, human; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: NT-proBNP; coronary artery disease; hs cardiac troponin T; myocardial ischemia; stable angina