title: Advances in dosimetry and biological predictors of radiation-induced esophagitis.
abstract: OBJECTIVE
  To summarize the research progress about the dosimetry and biological predictors of radiation-induced esophagitis.
  
  
  METHODS
  We performed a systematic literature review addressing radiation esophagitis in the treatment of lung cancer published between January 2009 and May 2015 in the PubMed full-text database index systems.
  
  
  RESULTS
  Twenty-eight eligible documents were included in the final analysis. Many clinical factors were related to the risk of radiation esophagitis, such as elder patients, concurrent chemoradiotherapy, and the intense radiotherapy regimen (hyperfractionated radiotherapy or stereotactic body radiotherapy). The parameters including Dmax, Dmean, V20, V30, V50, and V55 may be valuable in predicting the occurrence of radiation esophagitis in patients receiving concurrent chemoradiotherapy. Genetic variants in inflammation-related genes are also associated with radiation-induced toxicity.
  
  
  CONCLUSIONS
  Dosimetry and biological factors of radiation-induced esophagitis provide clinical information to decrease its occurrence and grade during radiotherapy. More prospective studies are warranted to confirm their prediction efficacy.
authors: School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, University of Jinan, Jinan, People's Republic of China.
authors: Yang
authors: Y
authors: Yu
authors: School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, University of Jinan, Jinan, People's Republic of China.
authors: Hui
authors: H
authors: Guan
authors: School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, University of Jinan, Jinan, People's Republic of China.
authors: Yuanli
authors: Y
authors: Dong
authors: Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong Province, People's Republic of China.
authors: Ligang
authors: L
authors: Xing
authors: Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong Province, People's Republic of China.
authors: Xiaolin
authors: X
authors: Li
keywords: esophagitis; lung cancer; predictors; radiation injuries