title: Ficus recemosa bark extract attenuates diabetic complications and oxidative stress in STZ-induced diabetic rats.
abstract: Context Ficus recemosa Linn. (Moraceae) has been reported as a natural folk medicine with diverse pathological activities such as antioxidant, antidiabetic, renoprotective and cardioprotective. Objective The present study evaluates the preventive effect of standardised ethanol extract of F. racemosa stem bark (EEFSB) on diabetic cardiomyopathy (DC) and diabetic nephropathy (DN). Materials and methods Animals were rendered diabetic by one time administration of STZ (45 mg kg(-1), i.v.) and, after 7 d, diabetic rats were randomised into four groups of eight rats each. EEFSB (200 and 400 mg kg(-1)) was administered to diabetic rats once daily for 8 weeks. Furthermore, the presence of phytochemicals was evaluated by HPTLC. Results Treatment with EEFSB markedly restores the blood glucose and lipid level (p < 0.001), also reduced creatinine kinase (p < 0.001), lactate dehydrogenase (p < 0.001), C-reactive protein (p < 0.001), creatinine (p < 0.001), blood urea nitrogen (p < 0.001), collagen (p < 0.05) and albumin (p < 0.001) levels. Reduced level of sodium (p < 0.001), creatinine (p < 0.001), albumin (p < 0.001) and malondialdehyde (p < 0.01) in heart and kidney tissue along with enhanced activities of superoxide dismutase (p < 0.001) and reduced glutathione (p < 0.001). Moreover, left ventricular hypertrophic index and cardiac hypertrophic index were markedly reduced by EEFSB treatment. Conclusion The findings of this study provided strong scientific evidence for the traditional use of F. racemosa and postulate protective effects against diabetes and its complications such as DC and DN.
authors: a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.
authors: Hiral
authors: H
authors: Joshi
authors: a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.
authors: Devendra
authors: D
authors: Vaishnav
authors: a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.
authors: Gaurav
authors: G
authors: Sanghvi
authors: a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.
authors: Samir
authors: S
authors: Rabadia
authors: a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.
authors: Vishal
authors: V
authors: Airao
authors: a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.
authors: Tejas
authors: T
authors: Sharma
authors: a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.
authors: Sachin
authors: S
authors: Parmar
authors: a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.
authors: Navin
authors: N
authors: Sheth
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002855:Chromatography, Thin Layer; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D058065:Diabetic Cardiomyopathies / Q000097:blood / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D003928:Diabetic Nephropathies / Q000097:blood / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D030681:Ficus / Q000737:chemistry; D017379:Hypertrophy, Left Ventricular / Q000139:chemically induced / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D000432:Methanol / Q000737:chemistry; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry; D013311:Streptozocin; D013997:Time Factors
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D012997:Solvents; D013311:Streptozocin; D000432:Methanol
keywords: Antioxidants; cardiomyopathy; diabetes mellitus; nephropathy