title: Carotid Intima-Media Thickness is Not Associated with Markers of Atherosclerosis in Stroke Patients.
abstract: BACKGROUND
  It has been argued that carotid intima-media thickness (IMT) could better reflect an adaptive response of the vessel wall rather than being a marker of atherosclerosis. We explore this hypothesis by analyzing the ARTICO data.
  
  
  METHODS
  The ARTICO study was designed to evaluate the prognostic value of the pathological ankle-brachial index (ABI) for the emergence of new vascular events in patients who have suffered a noncardioembolic stroke. Collected variables were as follows: vascular risk factors, mean waist perimeter, quantification of carotid IMT, characteristics of carotid plaques, ABI, and presence of microalbuminuria.
  
  
  RESULTS
  A total of 591 patients with a complete carotid evaluation were available. There was no correlation between ABI and IMT (Spearman's, p NS). Logistic regression revealed that pathological ABI correlated significantly only with internal carotid artery stenosis greater than or equal to 50% (OR [odds ratio] 2.80, 1.66-4.71, P < .01) and peripheral artery disease (OR 3.33, 1.63-6.78, P < .01). However, multivariate regression analysis demonstrated that carotid IMT was independently associated with age (OR 1.05, 95% confidence interval [CI] 1.02-1.09, P < .01), hypertension (OR 1.83, 95% CI 1.02-3.26, P = .04), waist circumference (OR 1.03, 95% CI 1.01-1.05, P < .01), and microalbuminuria (OR 2.02, 95% CI 1.22-3.35, P < .01).
  
  
  CONCLUSIONS
  In our patients, carotid IMT does not seem to be associated with unequivocal markers of atheromatosis such as the existence of relevant carotid plaques or pathological ABI. These results as well as the association of IMT with age, hypertension, microalbuminuria, and mean waist perimeter support the hypothesis that IMT must be considered a risk factor for general vascular disease rather than a marker of atherosclerotic burden.
authors: Department of Neurology, Hospital Universitario de Albacete, Albacete, Spain. Electronic address: jggpillarno@hotmail.com.
authors: Jorge
authors: J
authors: García García
authors: Department of Neurology, Hospital Universitari del Mar, Parc de Salut Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), DCEXS Universitat Pompeu Fabra, Barcelona, Spain.
authors: Jaume
authors: J
authors: Roquer
authors: Department of Neurology, Hospital Universitario Dr. Josep Trueta, Institut d'Investigació Biomèdica de Girona, Girona, Spain.
authors: Joaquín
authors: J
authors: Serena
authors: Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors: José
authors: J
authors: Castillo
authors: Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors: Miguel
authors: M
authors: Blanco
authors: Department of Neurology, Hospital Universitario de Albacete, Albacete, Spain.
authors: Inmaculada
authors: I
authors: Díaz-Maroto
authors: Department of Neurology, Hospital Universitario de Albacete, Albacete, Spain.
authors: Tomás
authors: T
authors: Segura
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000150:complications / Q000000981:diagnostic imaging*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D013030:Spain; D020521:Stroke / Q000209:etiology*; D018615:Ultrasonography, Doppler, Color
keywords: Intima-media thickness; ankle-brachial index; atherothrombotic; carotid plaque; ischemic stroke; risk factors; ultrasound