title: Catalytic Asymmetric Synthesis of anti-α,β-Diamino Acid Derivatives.
abstract: A novel approach to chiral anti-α,β-diamino acid derivatives through tandem orthogonal organocatalysis has been developed. Chiral phosphoric acid catalysts control the chemo-, regio-, and stereoselective addition of hydroxylamines to alkylideneoxazolones, while a phosphine catalyst promotes the isomerization of Z- alkylideneoxazolones to the more reactive E- alkylideneoxazolones.
authors: Graduate School of Pharmaceutical Sciences, Kyoto University , Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
authors: Sanae
authors: S
authors: Izumi
authors: Graduate School of Pharmaceutical Sciences, Kyoto University , Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
authors: Yusuke
authors: Y
authors: Kobayashi
authors: Graduate School of Pharmaceutical Sciences, Kyoto University , Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
authors: Yoshiji
authors: Y
authors: Takemoto
mesh_terms: D000599:Amino Acids, Diamino / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000599:Amino Acids, Diamino; D010756:Phosphoric Acids; C030242:phosphoric acid