title: Integrated systems of stroke care and reduction in 30-day mortality: A retrospective analysis.
abstract: OBJECTIVE
  To evaluate the association between the presence of integrated systems of stroke care and stroke case-fatality across Canada.
  
  
  METHODS
  We used the Canadian Institute of Health Information's Discharge Abstract Database to retrospectively identify a cohort of stroke/TIA patients admitted to all acute care hospitals, excluding the province of Quebec, in 11 fiscal years from 2003/2004 to 2013/2014. We used a modified Poisson regression model to compute the adjusted incidence rate ratio (aIRR) of 30-day in-hospital mortality across time for provinces with stroke systems compared to those without, controlling for age, sex, stroke type, comorbidities, and discharge year. We conducted surveys of stroke care resources in Canadian hospitals in 2009 and 2013, and compared resources in provinces with integrated systems to those without.
  
  
  RESULTS
  A total of 319,972 patients were hospitalized for stroke/TIA. The crude 30-day mortality rate decreased from 15.8% in 2003/2004 to 12.7% in 2012/2013 in provinces with stroke systems, while remaining 14.5% in provinces without such systems. Starting with the fiscal year 2009/2010, there was a clear reduction in relative mortality in provinces with stroke systems vs those without, sustained at aIRR of 0.85 (95% confidence interval 0.79-0.92) in the 2011/2012, 2012/2013, and 2013/2014 fiscal years. The surveys indicated that facilities in provinces with such systems were more likely to care for patients on a stroke unit, and have timely access to a stroke prevention clinic and telestroke services.
  
  
  CONCLUSIONS
  In this retrospective study, the implementation of integrated systems of stroke care was associated with a population-wide reduction in mortality after stroke.
authors: From the Calgary Stroke Program, Department of Clinical Neurosciences (A.G.), and Departments of Clinical Neurosciences, Medicine, Radiology, and Community Health Sciences, Hotchkiss Brain Institute, Faculty of Medicine (M.D.H.), University of Calgary; The Heart & Stroke Foundation of Canada (P.L., I.J.), Ottawa; Institute for Clinical Evaluative Sciences (J.F., M.K.K.), Toronto; Department of Medicine (M.K.K.), University of Toronto; Department of Neurology (R.C.), McGill University, Montréal; and Division of Neurology and Ottawa Hospital Research Institute (A.M.H.), University of Ottawa and The Heart & Stroke Foundation Centre for Stroke Recovery, Ottawa, Canada.
authors: Aravind
authors: A
authors: Ganesh
authors: From the Calgary Stroke Program, Department of Clinical Neurosciences (A.G.), and Departments of Clinical Neurosciences, Medicine, Radiology, and Community Health Sciences, Hotchkiss Brain Institute, Faculty of Medicine (M.D.H.), University of Calgary; The Heart & Stroke Foundation of Canada (P.L., I.J.), Ottawa; Institute for Clinical Evaluative Sciences (J.F., M.K.K.), Toronto; Department of Medicine (M.K.K.), University of Toronto; Department of Neurology (R.C.), McGill University, Montréal; and Division of Neurology and Ottawa Hospital Research Institute (A.M.H.), University of Ottawa and The Heart & Stroke Foundation Centre for Stroke Recovery, Ottawa, Canada.
authors: Patrice
authors: P
authors: Lindsay
authors: From the Calgary Stroke Program, Department of Clinical Neurosciences (A.G.), and Departments of Clinical Neurosciences, Medicine, Radiology, and Community Health Sciences, Hotchkiss Brain Institute, Faculty of Medicine (M.D.H.), University of Calgary; The Heart & Stroke Foundation of Canada (P.L., I.J.), Ottawa; Institute for Clinical Evaluative Sciences (J.F., M.K.K.), Toronto; Department of Medicine (M.K.K.), University of Toronto; Department of Neurology (R.C.), McGill University, Montréal; and Division of Neurology and Ottawa Hospital Research Institute (A.M.H.), University of Ottawa and The Heart & Stroke Foundation Centre for Stroke Recovery, Ottawa, Canada.
authors: Jiming
authors: J
authors: Fang
authors: From the Calgary Stroke Program, Department of Clinical Neurosciences (A.G.), and Departments of Clinical Neurosciences, Medicine, Radiology, and Community Health Sciences, Hotchkiss Brain Institute, Faculty of Medicine (M.D.H.), University of Calgary; The Heart & Stroke Foundation of Canada (P.L., I.J.), Ottawa; Institute for Clinical Evaluative Sciences (J.F., M.K.K.), Toronto; Department of Medicine (M.K.K.), University of Toronto; Department of Neurology (R.C.), McGill University, Montréal; and Division of Neurology and Ottawa Hospital Research Institute (A.M.H.), University of Ottawa and The Heart & Stroke Foundation Centre for Stroke Recovery, Ottawa, Canada.
authors: Moira K
authors: MK
authors: Kapral
authors: From the Calgary Stroke Program, Department of Clinical Neurosciences (A.G.), and Departments of Clinical Neurosciences, Medicine, Radiology, and Community Health Sciences, Hotchkiss Brain Institute, Faculty of Medicine (M.D.H.), University of Calgary; The Heart & Stroke Foundation of Canada (P.L., I.J.), Ottawa; Institute for Clinical Evaluative Sciences (J.F., M.K.K.), Toronto; Department of Medicine (M.K.K.), University of Toronto; Department of Neurology (R.C.), McGill University, Montréal; and Division of Neurology and Ottawa Hospital Research Institute (A.M.H.), University of Ottawa and The Heart & Stroke Foundation Centre for Stroke Recovery, Ottawa, Canada.
authors: Robert
authors: R
authors: Côté
authors: From the Calgary Stroke Program, Department of Clinical Neurosciences (A.G.), and Departments of Clinical Neurosciences, Medicine, Radiology, and Community Health Sciences, Hotchkiss Brain Institute, Faculty of Medicine (M.D.H.), University of Calgary; The Heart & Stroke Foundation of Canada (P.L., I.J.), Ottawa; Institute for Clinical Evaluative Sciences (J.F., M.K.K.), Toronto; Department of Medicine (M.K.K.), University of Toronto; Department of Neurology (R.C.), McGill University, Montréal; and Division of Neurology and Ottawa Hospital Research Institute (A.M.H.), University of Ottawa and The Heart & Stroke Foundation Centre for Stroke Recovery, Ottawa, Canada.
authors: Ian
authors: I
authors: Joiner
authors: From the Calgary Stroke Program, Department of Clinical Neurosciences (A.G.), and Departments of Clinical Neurosciences, Medicine, Radiology, and Community Health Sciences, Hotchkiss Brain Institute, Faculty of Medicine (M.D.H.), University of Calgary; The Heart & Stroke Foundation of Canada (P.L., I.J.), Ottawa; Institute for Clinical Evaluative Sciences (J.F., M.K.K.), Toronto; Department of Medicine (M.K.K.), University of Toronto; Department of Neurology (R.C.), McGill University, Montréal; and Division of Neurology and Ottawa Hospital Research Institute (A.M.H.), University of Ottawa and The Heart & Stroke Foundation Centre for Stroke Recovery, Ottawa, Canada.
authors: Antoine M
authors: AM
authors: Hakim
authors: From the Calgary Stroke Program, Department of Clinical Neurosciences (A.G.), and Departments of Clinical Neurosciences, Medicine, Radiology, and Community Health Sciences, Hotchkiss Brain Institute, Faculty of Medicine (M.D.H.), University of Calgary; The Heart & Stroke Foundation of Canada (P.L., I.J.), Ottawa; Institute for Clinical Evaluative Sciences (J.F., M.K.K.), Toronto; Department of Medicine (M.K.K.), University of Toronto; Department of Neurology (R.C.), McGill University, Montréal; and Division of Neurology and Ottawa Hospital Research Institute (A.M.H.), University of Ottawa and The Heart & Stroke Foundation Centre for Stroke Recovery, Ottawa, Canada. michael.hill@ucalgary.ca.
authors: Michael D
authors: MD
authors: Hill
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002170:Canada / Q000453:epidemiology; D015331:Cohort Studies; D019033:Delivery of Health Care, Integrated / Q000379:methods / Q000639:trends*; D005260:Female; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D008297:Male; D008875:Middle Aged; D005791:Patient Care / Q000379:methods / Q000401:mortality* / Q000639:trends; D012189:Retrospective Studies; D020521:Stroke / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy*