title: Childhood colon cancer in a patient with ataxia telangiectasia.
abstract: BACKGROUND
  Ataxia-telangiectasia (AT) is a rare autosomal recessive disease characterized by progressive neurologic impairment and cerebellar ataxia. In addition, patients with this disease are known to have an inherent increased susceptibility to the development of cancer, predominantly hematologic malignancies.
  
  
  METHODS
  We report the case of a young boy with AT from Russia, who had abdominal pain. Laboratory tests and radiologic examinations were performed to him.
  
  
  RESULTS
  After abdominal computed tomography (CT), colonoscopy and surgical interventions, the young boy was diagnosed with colon cancer that had signet ring cell features.
  
  
  CONCLUSIONS
  It is known that the patient with AT appeared to be predisposed to various tumors, including leukemia or lymphoma, which are more common in childhood. Even if the patient with AT could have solid tumor such as stomach cancer or breast cancer, it is less likely to have colon cancer, especially signet ring cell type. Actually, no case of colon cancer has ever been reported, especially in young patient and hence, we have focused on this point and are hereby reporting this unique case.
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Kyeong Min
authors: KM
authors: Jo
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Sung Yeun
authors: SY
authors: Yang
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Jong Ha
authors: JH
authors: Park
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Tae Oh
authors: TO
authors: Kim
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Heui Jeong
authors: HJ
authors: Jeong
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Chang Min
authors: CM
authors: Heo
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Ji Hoon
authors: JH
authors: Jang
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: So Chong
authors: SC
authors: Hur
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Na Ri
authors: NR
authors: Jeong
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Su Jin
authors: SJ
authors: Jeong
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Sang Hoon
authors: SH
authors: Seol
authors: 1 Department of Internal Medicine, 2 Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
authors: Kyung Han
authors: KH
authors: Nam
keywords: Ataxia-telangiectasia (AT); childhood colon cancer; signet ring cell