title: Accelerating Lead Compound Optimization.
abstract: Chemists at The Scripps Research Institute in La Jolla, CA, and Pfizer's La Jolla Laboratories have devised a new way to rapidly synthesize strained-ring structures, which are increasingly favored to optimize potential drugs. With this method, strain-release amination, Pfizer researchers were able to produce sufficient quantities of a particular structure they needed to evaluate a promising cancer drug candidate.
authors: Alissa
authors: A
authors: Poh
mesh_terms: D055808:Drug Discovery / Q000379:methods / Q000592:standards; D006801:Humans