title: Association of RBP4 levels with increased arterial stiffness in adolescents with family history of type 2 diabetes.
abstract: BACKGROUND
  The aim of this study was to explore the impact of family history of type 2 diabetes (FH2D) on arterial stiffness in young people and its relationship to adipocytokines.
  
  
  METHODS
  This case-control study included 52 adolescents (male/female 28/24) with FH2D (FH2D+) and 40 adolescents (male/female 21/19) without FH2D (FH2D-). Anthropometric measurements, including height, weight, waist circumference (WC), and blood pressure, were obtained. Blood samples were collected, fasting plasma glucose (FPG), serum lipids, Retinol Binding Protein 4 (RBP4), C reactive protein (CRP), adiponectin and visfatin were examined. Brachial-ankle pulse wave velocity (baPWV) was used to evaluate arterial stiffness. Visceral fat area (VFA) was measured by computerized tomography.
  
  
  RESULTS
  Compared with FH2D- group, FH2D+ group had a significantly higher oral glucose tolerance test (OGTT) 2-hour insulin, RBP4 and baPWV levels, a lower adiponectin and glucose infusing rate (GIR) (P<0.05). BaPWV was positively correlated with age, systolic blood pressure (SBP), diastolic blood pressure (DBP), 2-hour (OGTT) insulin, RBP4, and VFA, and negatively correlated with GIR in FH2D+ group. After multivariate analysis, age, SBP, RBP4 and VFA maintained an independent association with baPWV in FH2D+ group (P<0.05), while only age, SBP, and VFA were independent predictors of baPWV in FH2D- group (P<0.05).
  
  
  CONCLUSIONS
  These findings led to the conclusion that RBP4 level was associated with increased arterial stiffness in young subjects with family history of type 2 diabetes.
authors: Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China - sguangyao3@163.com.
authors: Ping
authors: P
authors: Li
authors: Yamin
authors: Y
authors: Lu
authors: Guangyao
authors: G
authors: Song
authors: Boqing
authors: B
authors: Ma
authors: Jing
authors: J
authors: Liu
authors: Jinhu
authors: J
authors: Chen
authors: Chao
authors: C
authors: Liu
mesh_terms: D050154:Adiposity; D000328:Adult; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D010375:Pedigree; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D015854:Up-Regulation; D059289:Vascular Stiffness; D055815:Young Adult
chemical_list: D015415:Biomarkers; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma