title: Naphthoflavones as Antiproliferative Agents: Design, Synthesis and Biological Evaluation.
abstract: The present study involves the design and synthesis of naphthoflavones as antiproliferative agents. The strategy presents naphthoflavones as hybrids of naphthyl based chalcones and flavones. A panel of human cancer cell lines were employed for the cytotoxicity studies. DK-13 exhibited significant cytoxicity against MiaPaCa-2 cell lines with IC50 value of 1.93 μM and 5.63 μM against MCF-7 cell lines. The compound DK-13 was found to induce apoptosis evidenced through phase contrast microscopy, DAPI staining, and mitochondrial membrane potential loss. The cell phase distribution studies indicated an increase from 11.26 % (control sample) to 55.19 % (sample treated with 20 μM compound DK-13) in the apoptotic population.
authors: Dinesh
authors: D
authors: Kumar
authors: Onkar
authors: O
authors: Singh
authors: Kunal
authors: K
authors: Nepali
authors: Pms
authors: P
authors: Bedi
authors: Arem
authors: A
authors: Qayum
authors: Shashank
authors: S
authors: Singh
authors: Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab-143005. kunal_8855@rediffmail.com.
authors: Subheet K
authors: SK
authors: Jain
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D015195:Drug Design; D047309:Flavones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans
chemical_list: D047309:Flavones