title: Asthma phenotypes in childhood.
abstract: OBJECTIVE
  This review describes the literature over the past 18 months that evaluated childhood asthma phenotypes, highlighting the key aspects of these studies, and comparing these studies to previous ones in this area.
  
  
  RESULTS
  Recent studies on asthma phenotypes have identified new phenotypes on the basis of statistical analyses (using cluster analysis and latent class analysis methodology) and have evaluated the outcomes and associated risk factors of previously established early childhood asthma phenotypes that are based on asthma onset and patterns of wheezing illness. There have also been investigations focusing on immunologic, physiologic, and genetic correlates of various phenotypes, as well as identification of subphenotypes of severe childhood asthma.
  
  
  CONCLUSIONS
  Childhood asthma remains a heterogeneous condition, and investigations into these various presentations, risk factors, and outcomes are important since they can offer therapeutic and prognostic relevance. Further investigation into the immunopathology and genetic basis underlying childhood phenotypes is important so therapy can be tailored accordingly.
authors: aNational Jewish Health, Department of Pediatrics bUniversity of Colorado Denver Health Sciences Center, Denver, Colorado, USA.
authors: Monica B
authors: MB
authors: Reddy
authors: Ronina A
authors: RA
authors: Covar
mesh_terms: D000818:Animals; D001249:Asthma / Q000145:classification / Q000175:diagnosis*; D002648:Child; D016000:Cluster Analysis; D006801:Humans; D010641:Phenotype; D011379:Prognosis; D012135:Respiratory Sounds / Q000209:etiology; D012307:Risk Factors