title: How breast cancer chemotherapy increases the risk of leukemia: Thoughts about a case of diffuse large B-cell lymphoma and leukemia after breast cancer chemotherapy.
abstract: The latest studies suggest that prophylactic chemotherapy or adjuvant chemotherapy for early stage breast cancer may increase the leukemia risk in patients. For patients with a low risk for breast cancer recurrence, physicians who make the choice for adjuvant therapy should consider the risk of its long-term side effects. Is the occurrence of lymphatic system cancer and leukemia after breast cancer treatment associated with chemotherapy? Can these types of leukemia be classified as therapy-related leukaemias? We believe that there may be correlations between any diseases, butwe cannot rush to conclusions or dismiss a correlation because we understand little about the diseases themselves.In this paper, we present a case of secondary diffuse large B-cell lymphoma and leukemia in patients after breast cancer chemotherapy, it is undeniable that this is a special event. For two distinct tumouroccurrences at different times, we cannot give a clear explanation because of thechanges in the genes that might link them together and we hope to attract the attention of other clinicians.
authors: a Department of Radiation Oncology , Shandong Cancer Hospital and Institute, Shandong University , Jinan , P.R. China.|b Department of Oncology , The First Affiliated Hospital of Dalian Medical University , Dalian , P.R. China.
authors: Bin
authors: B
authors: Zhang
authors: c Department of Oncology , Shandong Cancer Hospital and Institute, Shandong University , Jinan , P.R. China.
authors: Xia
authors: X
authors: Zhang
authors: a Department of Radiation Oncology , Shandong Cancer Hospital and Institute, Shandong University , Jinan , P.R. China.
authors: Minghuan
authors: M
authors: Li
authors: a Department of Radiation Oncology , Shandong Cancer Hospital and Institute, Shandong University , Jinan , P.R. China.
authors: Li
authors: L
authors: Kong
authors: d Department of Radiation Oncology , The First Affiliated Hospital of Dalian Medical University , Dalian , P.R. China.
authors: Xiaoqin
authors: X
authors: Deng
authors: a Department of Radiation Oncology , Shandong Cancer Hospital and Institute, Shandong University , Jinan , P.R. China.
authors: Jinming
authors: J
authors: Yu
mesh_terms: D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology*
keywords: Breast cancer; bone marrow puncture; lymphoma; lymphoma cell leukemia; therapy-related leukaemias