title: Psoralea corylifolia L. Seed Extract Attenuates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice.
abstract: Nonalcoholic fatty liver disease (NAFLD), along with obesity, is increasing world-wide and is one of the major causes of chronic hepatic disease. The present study evaluated the ameliorative effect of extract of Psoralea corylifolia L. seed (PCS) on high fat diet-induced NAFLD in C57BL/6 mice after daily administration at 300 or 500 mg/kg for 12 weeks. Treatment with PCS extract significantly reduced body weight and blood glucose levels and improved glucose tolerance and insulin sensitivity. In addition, PCS extract treatment significantly attenuated lipid accumulation in liver and adipose tissue and reduced serum lipid and hepatic triglyceride levels. Furthermore, the expression of lipogenic genes and inflammatory genes were reduced, and the expression of fat oxidation-related genes was increased in the liver of PCS extract-treated mice compared with control mice. Our study suggests the therapeutic potential of PCS extract for NAFLD by inhibiting lipid accumulation and inflammation in liver.
authors: College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Korea.|Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.
authors: Eunhui
authors: E
authors: Seo
authors: Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.|Gachon Medical Research Institute, Gil Hospital, Incheon 21565, Korea.
authors: Yoon Sin
authors: YS
authors: Oh
authors: College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Korea. hsjun@gachon.ac.kr.|Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea. hsjun@gachon.ac.kr.|Gachon Medical Research Institute, Gil Hospital, Incheon 21565, Korea. hsjun@gachon.ac.kr.
authors: Hee-Sook
authors: HS
authors: Jun
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat; D007249:Inflammation / Q000235:genetics; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects* / Q000235:genetics; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D065626:Non-alcoholic Fatty Liver Disease / Q000209:etiology / Q000517:prevention & control*; D009765:Obesity / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D010084:Oxidation-Reduction; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D029907:Psoralea; D012639:Seeds
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts
keywords: Psoralea corylifolia L. seed; diabetes; nonalcoholic fatty liver disease; obesity