title: Technical Note: On GAFChromic EBT-XD film and the lateral response artifact.
abstract: OBJECTIVE
  The new radiochromic film, GAFChromic EBT-XD, contains the same active material, lithium-10,12-pentacosadiynoate, as GAFChromic EBT3, but the crystalline form is different. This work investigates the effect of this change on the well-known lateral response artifact when EBT-XD film is digitized on a flatbed scanner.
  
  
  METHODS
  The dose response of a single production lot of EBT-XD was characterized by scanning an unexposed film plus a set of films exposed to doses between 2.5 and 50 Gy using 6 MV photons. To characterize the lateral response artifact, the authors used the unexposed film plus a subset of samples exposed to doses between 20 and 50 Gy. Digital images of these films were acquired at seven discrete lateral locations perpendicular to the scan direction on three Epson 10000XL scanners. Using measurements at the discrete lateral positions, the scanner responses were determined as a function of the lateral position of the film. From the data for each scanner, a set of coefficients were derived whereby measured response values could be corrected to remove the effects of the lateral response artifact. The EBT-XD data were analyzed as in their previous work and compared to results reported for EBT3 in that paper.
  
  
  RESULTS
  For films scanned in the same orientation and having equal responses, the authors found that the lateral response artifact for EBT-XD and EBT3 films was remarkably similar. For both films, the artifact increases with increased net response. However, as EBT-XD is less sensitive than EBT3, a greater exposure dose is required to reach the same net response. On this basis, the lower sensitivity of EBT-XD relative to EBT3 results in less net response change for equal exposure and a reduction in the impact of the lateral response artifact.
  
  
  CONCLUSIONS
  The shape of the crystalline active component in EBT-XD and EBT3 does not affect the fundamental existence of the lateral response artifact when the films are digitized on flatbed scanners. Owing its lower sensitivity, EBT-XD film requires higher dose to reach the same response as EBT3, resulting in lesser impact of the lateral response artifact. For doses >10 Gy, the slopes of the EBT-XD red and green channel dose response curves are greater than the corresponding ones for EBT3. For these two reasons, the authors prefer EBT-XD for doses exceeding about 10 Gy.
authors: RC Film Consulting LLC, 54 Benedict Road, Monroe, Connecticut 06468.
authors: David F
authors: DF
authors: Lewis
authors: Memorial Sloan-Kettering Cancer Center, 136 Mountain View Boulevard, Basking Ridge, New Jersey 07920.
authors: Maria F
authors: MF
authors: Chan
mesh_terms: D016477:Artifacts; D005373:Film Dosimetry / Q000379:methods*; D008094:Lithium / Q000737:chemistry; D009942:Organometallic Compounds; D017785:Photons; D011829:Radiation Dosage
chemical_list: D009942:Organometallic Compounds; D008094:Lithium