title: Jurassic PARK2: You eat your mitochondria, and you are what your mitochondria eat.
abstract: Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our findings demonstrate how functional interactions between mitophagic mitochondrial removal and biogenic mitochondrial replacement facilitate metabolic maturation of the heart.
authors: a Dept. of Internal Medicine , Center for Pharmacogenomics , Washington University , School of Medicine , St. Louis , MO , USA.
authors: Gerald W
authors: GW
authors: Dorn
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D032383:Myocytes, Cardiac / Q000378:metabolism; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein
keywords: Heart; Parkin; metabolomics; mitofusin 2; mitophagy; transcriptomics