title: Race-Specific Pharmacodynamic Model of Propofol-Induced Loss of Consciousness.
abstract: We present a race-specific model of propofol-induced loss of consciousness that is based on pharmacodynamic data collected and adapted from the peer-reviewed literature. In the proposed race-specific model that includes EC05 and EC95 concentrations, the median (EC50) (and where available 95%CI) propofol concentrations at the effect site compartment for propofol-induced loss of consciousness for whites, Chinese, blacks, and Indians are 2.8 (2.7-2.9), 2.2 (2.2-2.3), 2.0, and 1.9 μg/mL, respectively.
authors: Center for Safety, Simulation, and Advanced Learning Technologies, University of Florida, Gainesville, FL, USA.|Department of Anesthesiology, University of Florida, Gainesville, FL, USA.|Clinical & Translational Science Institute Simulation Core, University of Florida, Gainesville, FL, USA.|UF Health Shands Experiential Learning Center, University of Florida, Gainesville, FL, USA.
authors: Samsun
authors: S
authors: Lampotang
authors: Center for Safety, Simulation, and Advanced Learning Technologies, University of Florida, Gainesville, FL, USA.|Department of Anesthesiology, University of Florida, Gainesville, FL, USA.|Clinical & Translational Science Institute Simulation Core, University of Florida, Gainesville, FL, USA.
authors: David E
authors: DE
authors: Lizdas
authors: Department of Pharmaceutics, University of Florida, Gainesville, FL, USA.
authors: Hartmut
authors: H
authors: Derendorf
authors: Center for Safety, Simulation, and Advanced Learning Technologies, University of Florida, Gainesville, FL, USA.|Department of Anesthesiology, University of Florida, Gainesville, FL, USA.
authors: Nikolaus
authors: N
authors: Gravenstein
authors: Computer & Information Science and Engineering, University of Florida, Gainesville, FL, USA.
authors: Benjamin
authors: B
authors: Lok
authors: Department of Computer Science, University of Texas at San Antonio, San Antonio, TX, USA.
authors: John P
authors: JP
authors: Quarles
mesh_terms: D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D038622:Internationality; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015742:Propofol / Q000008:administration & dosage / Q000097:blood*; D011446:Prospective Studies; D044469:Racial Groups; D014474:Unconsciousness / Q000097:blood* / Q000139:chemically induced*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol
keywords: EC50; effect site compartment; loss of consciousness; propofol; race-specific model