title: Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin.
abstract: There is currently lack of information on the changes of acute phase proteins (APP) and antioxidant markers and their clinical relevance as treatment response indicators in canine monocytic ehrlichiosis (CME). The objective of this study was to investigate the patterns of C-reactive protein (CRP), haptoglobin (Hp), ferritin and paraoxonase-1 (PON-1) during treatment of dogs with acute CME with rifampicin. Blood serum samples from ten Beagle dogs with experimental acute CME were retrospectively examined. Five dogs (Group A) were treated with rifampicin (10mg/Kg/24h), per os, for 3 weeks and 5 dogs (Group B) received no treatment (infected controls). Two Beagle dogs served as uninfected controls. Blood serum samples were serially examined prior to Ehrlichia canis inoculation and on post-inoculation days 14, 21, 28, 35 and 42. Significant changes of CRP, Hp, ferritin and PON-1 values were found in the majority of infected dogs. However, their concentrations did not differ between the two groups during the treatment observation period. The results of this study indicate that although several APP and PON-1 tend to significantly change in the majority of dogs with acute CME, they were of limited clinical relevance as treatment response indicators in this experimental setting.
authors: Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki (CAC-AUTh), 11 Stavrou Voutyra Str., 54627 Thessaloniki, Greece.
authors: Dimitra
authors: D
authors: Karnezi
authors: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain.
authors: Jose J
authors: JJ
authors: Ceron
authors: Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki (CAC-AUTh), 11 Stavrou Voutyra Str., 54627 Thessaloniki, Greece.
authors: Konstantina
authors: K
authors: Theodorou
authors: Laboratory of Epidemiology, Biostatistics and Animal Health Economics, School of Veterinary Medicine, Faculty of Health Sciences, University of Thessaly, 224 Trikalon Str., 43100 Karditsa, Greece.
authors: Leonidas
authors: L
authors: Leontides
authors: Laboratory of Microbiology and Infectious Diseases, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University Campus,54124, Thessaloniki, Greece.
authors: Victoria I
authors: VI
authors: Siarkou
authors: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain.
authors: Silvia
authors: S
authors: Martinez
authors: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain.
authors: Asta
authors: A
authors: Tvarijonaviciute
authors: Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel.
authors: Shimon
authors: S
authors: Harrus
authors: Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki (CAC-AUTh), 11 Stavrou Voutyra Str., 54627 Thessaloniki, Greece.
authors: Christos K
authors: CK
authors: Koutinas
authors: Diagnostic Laboratory, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 11 Stavrou Voutyra Str., 54627, Thessaloniki, Greece.
authors: Dimitra
authors: D
authors: Pardali
authors: Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki (CAC-AUTh), 11 Stavrou Voutyra Str., 54627 Thessaloniki, Greece. Electronic address: mmylonak@vet.auth.gr.
authors: Mathios E
authors: ME
authors: Mylonakis
mesh_terms: D000209:Acute-Phase Proteins / Q000276:immunology; D000818:Animals; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000276:immunology; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy* / Q000276:immunology*; D004285:Dogs; D016873:Ehrlichiosis / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D005260:Female; D005293:Ferritins / Q000097:blood; D006242:Haptoglobins / Q000276:immunology; D008297:Male; D012293:Rifampin / Q000627:therapeutic use*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D006242:Haptoglobins; D002097:C-Reactive Protein; D005293:Ferritins; D043303:Aryldialkylphosphatase; D012293:Rifampin
keywords: Acute phase proteins; Dog; Ehrlichia canis; Paraoxonase-1