title: Polyphosphate and acidocalcisomes.
abstract: Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton pyrophosphatase (V-H(+)-PPase or VP1), the vacuolar proton ATPase (V-H(+)-ATPase) or both, maintain their acidity. A vacuolar transporter chaperone (VTC) complex is involved in the synthesis and translocation of polyP to these organelles in several eukaryotes, such as yeast, trypanosomatids, Apicomplexan and algae. Studies in trypanosomatids have revealed the role of polyP and acidocalcisomes in osmoregulation and calcium signalling.
authors: Center for Tropical and Global Emerging Diseases and Department of Cellular Biology, University of Georgia, Athens 30602, U.S.A. Departamento de Patología Clínica, Universidade Estadual de Campinas, São Paulo 13083-877, Brazil.
authors: Noelia
authors: N
authors: Lander
authors: Center for Tropical and Global Emerging Diseases and Department of Cellular Biology, University of Georgia, Athens 30602, U.S.A.
authors: Ciro
authors: C
authors: Cordeiro
authors: Center for Tropical and Global Emerging Diseases and Department of Cellular Biology, University of Georgia, Athens 30602, U.S.A.
authors: Guozhong
authors: G
authors: Huang
authors: Center for Tropical and Global Emerging Diseases and Department of Cellular Biology, University of Georgia, Athens 30602, U.S.A. Departamento de Patología Clínica, Universidade Estadual de Campinas, São Paulo 13083-877, Brazil rdocampo@cb.uga.edu.
authors: Roberto
authors: R
authors: Docampo
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism; D015388:Organelles / Q000378:metabolism*; D064587:Osmoregulation; D011122:Polyphosphates / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D026901:Membrane Transport Proteins; D011122:Polyphosphates; D002118:Calcium
keywords: acidocalcisome; calcium; contractile vacuole; osmoregulation; polyphosphate