title: Hippocampal but not amygdalar volume loss in narcolepsy with cataplexy.
abstract: OBJECTIVE
  Narcolepsy with cataplexy (NC) and narcolepsy without cataplexy (NwoC) are lifelong neurological disorders characterized primarily by excessive daytime sleepiness. Emotional events such as laughter are a trigger of cataplexy in NC.
  
  
  METHODS
  We compared the volumes of key limbic structures, the amygdala and hippocampus, in 53 NC, 23 NwoC and 37 control subjects. MRI volumetry was performed in FreeSurfer (FS) and by manual delineation.
  
  
  RESULTS
  We found no differences in amygdalar volume in the three groups, however, hippocampal volume was significantly smaller in the NC group than in other groups. Amygdalar and hippocampal volumes assessed by FS were significantly greater, but strong positive correlation between manual and FS results were observed. Thus, both methods are suitable for amygdalar and hippocampal volumetry.
authors: Department of Anatomy, Charles University in Prague, First Faculty of Medicine, Czech Republic.
authors: Veronika
authors: V
authors: Nemcova
authors: Department of Radiology, Charles University in Prague, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
authors: Jan
authors: J
authors: Krasensky
authors: Department of Neurology and Centre of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic.
authors: David
authors: D
authors: Kemlink
authors: Department of Anatomy, Charles University in Prague, First Faculty of Medicine, Czech Republic.
authors: Pavel
authors: P
authors: Petrovicky
authors: Department of Radiology, Charles University in Prague, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
authors: Manuela
authors: M
authors: Vaneckova
authors: Department of Radiology, Charles University in Prague, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
authors: Zdenek
authors: Z
authors: Seidl
authors: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic.
authors: Aaron
authors: A
authors: Rulseh
authors: National Institute of Mental Health, Klecany, Czech Republic.
authors: Jitka
authors: J
authors: Buskova
authors: Department of Neurology and Centre of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic.
authors: Marek
authors: M
authors: Susta
authors: Department of Neurology and Centre of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic.
authors: Karel
authors: K
authors: Sonka