title: Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits.
abstract: The precise connectivity of somatostatin and parvalbumin cortical interneurons is generated during development. An understanding of how these interneuron classes incorporate into cortical circuitry is incomplete but essential to elucidate the roles they play during maturation. Here, we report that somatostatin interneurons in infragranular layers receive dense but transient innervation from thalamocortical afferents during the first postnatal week. During this period, parvalbumin interneurons and pyramidal neurons within the same layers receive weaker thalamocortical inputs, yet are strongly innervated by somatostatin interneurons. Further, upon disruption of the early (but not late) somatostatin interneuron network, the synaptic maturation of thalamocortical inputs onto parvalbumin interneurons is perturbed. These results suggest that infragranular somatostatin interneurons exhibit a transient early synaptic connectivity that is essential for the establishment of thalamic feedforward inhibition mediated by parvalbumin interneurons.
authors: NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
authors: Sebnem N
authors: SN
authors: Tuncdemir
authors: NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
authors: Brie
authors: B
authors: Wamsley
authors: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors: Floor J
authors: FJ
authors: Stam
authors: Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors: Fumitaka
authors: F
authors: Osakada
authors: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors: Martyn
authors: M
authors: Goulding
authors: Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors: Edward M
authors: EM
authors: Callaway
authors: NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
authors: Bernardo
authors: B
authors: Rudy
authors: NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA. Electronic address: fisheg01@nyumc.org.
authors: Gord
authors: G
authors: Fishell
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology* / Q000254:growth & development* / Q000502:physiology; D007395:Interneurons / Q000502:physiology*; D051379:Mice; D009434:Neural Pathways / Q000254:growth & development* / Q000502:physiology; D010320:Parvalbumins / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology; D013004:Somatostatin / Q000502:physiology*; D013788:Thalamus / Q000254:growth & development / Q000502:physiology*
chemical_list: D010320:Parvalbumins; D013004:Somatostatin