title: Efficacy of Dragon's blood cream on wound healing: A randomized, double-blind, placebo-controlled clinical trial.
abstract: The blood-red sap of Dragon's blood has been used in folk medicine for fractures, wounds, inflammation, gastrointestinal disorders, rheumatism, blood circulation dysfunctions, and cancer. Existing in vitro and in vivo bioactivity of this herb on different mechanisms of healing shows strong potential of this sap in wound healing. This clinical trial study was designated to evaluate the wound healing effect of Dragon's blood on human wounds. Sixty patients, between the ages of 14-65 years, who were referred to remove their skin tag, were assigned to this double-blind, placebo-controlled, randomized clinical trial and received either Dragon's blood or a placebo cream. They were visited on the 3rd, 5th, 7th, 10th, 14th, and 20th day of the trial to check the process of healing and to measure the wound's surface. At the end of trial, there was a significant difference in the mean duration of wound healing between the two groups (p = 0.0001). The phenolic compounds and the alkaloid taspine, which exist in Dragon's-blood resin, are probably the main reasons for the wound healing property of this plant. Being natural accessible, safe, and affordable makes Dragon's blood cream, a good choice for addition to the wound healing armamentarium. Further studies on wounds with different causes and among larger populations are suggested to ensure the effectiveness and safety of Dragon's blood.
authors: Pharmacognosy Department, Marine Natural Pharmaceutical Research Center, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors: Foroogh
authors: F
authors: Namjoyan
authors: School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors: Fatemeh
authors: F
authors: Kiashi
authors: Dermatology Department, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors: Zahra Beigom
authors: ZB
authors: Moosavi
authors: School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors: Fatemeh
authors: F
authors: Saffari
authors: Pharmaceutics Department, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors: Behzad Sharif
authors: BS
authors: Makhmalzadeh
keywords: Dragon's blood; clinical trial; wound healing