title: A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia.
abstract: An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems.
authors: School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.|School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu Darul Iman, Malaysia.
authors: Laili
authors: L
authors: Che Rose
authors: Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
authors: Joseph C
authors: JC
authors: Bear
authors: School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
authors: Paul D
authors: PD
authors: McNaughter
authors: UCL Healthcare Biomagnetics Laboratories, Royal Institution of Great Britain, 21 Albemarle Street, London, W1S 4BS, UK.
authors: Paul
authors: P
authors: Southern
authors: Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK.
authors: R Ben
authors: RB
authors: Piggott
authors: Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
authors: Ivan P
authors: IP
authors: Parkin
authors: School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
authors: Sheng
authors: S
authors: Qi
authors: School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
authors: Andrew G
authors: AG
authors: Mayes
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D052203:Ferrosoferric Oxide / Q000737:chemistry; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000473:Alkanes; D002214:Capsules; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D014867:Water; C050821:eicosane; D052203:Ferrosoferric Oxide