title: Evaluation of oxidant/anti-oxidants status in patients with mild acute -pancreatitis.
abstract: OBJECTIVE
  Acute pancreatitis (AP), an inflammatory disorder of the pancreas, is associated with significant morbidity and mortality. The pathogenesis of AP has been suggested to -involve high oxidative stress (OS), combined with inadequate antioxidant status. We aimed to investigate the levels of serum total anti-oxidant status (TAS), total oxidant status (TOS) and ischemia-modified albumin (IMA) in patients with mild AP2016.
  
  
  METHODS
  Thirty subjects with mild AP and 29 healthy controls were enrolled into the study. The levels of TAS, TOS and IMA, C-reactive protein (CRP), high sensitivity CRP (hs-CRP) and fibrinogen were measured in both groups.
  
  
  RESULTS
  TAS levels were significantly lower (p = 0.037), while IMA levels were significantly higher (p < 0.001) in patients, compared to controls. TOS levels were similar between two groups. Fibrinogen, CRP and hs-CRP levels were significantly higher in patients than those of controls (p < 0.001 for all parameters). IMA levels were positively correlated with amylase and lipase levels (r = 0.448, p = 0.001 and r = 0.469, p < 0.001, respectively). There was a negative correlation between TAS levels, and amylase and lipase levels (r = -0.277, p = 0.035 and r = -0.278, p = 0.034, respectively).
  
  
  CONCLUSIONS
  OS is reported to be associated with the inflammatory process and the severity of AP. In our study, among OS parameters, an increase in IMA levels and a decrease in TAS levels were observed in mild AP patients.
authors: H
authors: H
authors: Baser
authors: U
authors: U
authors: Can
authors: D
authors: D
authors: Karasoy
authors: A S
authors: AS
authors: Ay
authors: S
authors: S
authors: Baser
authors: F H
authors: FH
authors: Yerlikaya
authors: S
authors: S
authors: Ecirli
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000681:Amylases / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008049:Lipase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress; D010195:Pancreatitis / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*; D000075462:Serum Albumin, Human; D012720:Severity of Illness Index
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D012709:Serum Albumin; C561522:ischemia-modified albumin; D005340:Fibrinogen; D002097:C-Reactive Protein; D008049:Lipase; D000681:Amylases; D000075462:Serum Albumin, Human