title: Retardation of fracture healing by cerclage wire near the elbow in radius fracture models.
abstract: Cerclage wire is widely used in the treatment of fracture internal fixation and is shown effective in clinic. But a report by S.L. has pointed that the wire loop delayed the growth of bone. We have established a radius fracture model to study the possible detrimental effects of cerclage wire on fracture healing and the potential mechanism. By high-resolution CT analysis cerclage wire is found to delay fracture healing, by histological assessment cerclage wire is found to extended the time of hematoma and the marrow cavity appearing, by confocal microscopy cerclage wire decreased the content of calcium and the expression of alkaline phosphatase (ALP), and by RT-PCR analysis cerclage wire decreased the mRNA levels of bone sialoprotein and ALP. These results suggest that the cerclage wire near the elbow delayed the fracture healing in radius fracture models.
authors: College of Veterinary Medicine, Jilin University, China.
authors: Fangning
authors: F
authors: Liu
authors: Fuwai Hospital CAMS & PUMC, National Center for Cardiovascular Diseases, China.
authors: Bin
authors: B
authors: Li
authors: College of Veterinary Medicine, Jilin University, China.
authors: Haiyu
authors: H
authors: Wang
authors: The Second Hospital of Jilin University, China.
authors: Qinghe
authors: Q
authors: Han
authors: The Second Hospital of Jilin University, China.
authors: Guoxi
authors: G
authors: Shao
authors: College of Veterinary Medicine, Jilin University, China.
authors: Yingjie
authors: Y
authors: Gao
authors: College of Veterinary Medicine, Jilin University, China. Electronic address: xiegh@jlu.edu.cn.
authors: Guanghong
authors: G
authors: Xie
mesh_terms: D000818:Animals; D001864:Bone Wires / Q000662:veterinary*; D005260:Female; D005593:Fracture Fixation, Internal / Q000662:veterinary*; D017102:Fracture Healing; D011817:Rabbits; D011884:Radius / Q000293:injuries* / Q000601:surgery; D011885:Radius Fractures / Q000601:surgery / Q000662:veterinary*; D051381:Rats
keywords: Bone defect; Cerclage wire; Fracture healing