title: Optimization and development of Nisoldipine nano-bioenhancers by novel orthogonal array (L27 array).
abstract: Our key objective was an attempt to apply a novel statistical method intended for designing, optimizing and developing Nisoldipine nano-bioenhancers using Taguchi (3 × 3=L27) design. This quality improvement orthogonal design array (L27) was used as a mathematical tool to find and study the response prediction of independent as well as significant variables (A=poly-concentration; B=bio-enhancer and C=ratio of organic medium). The array orthogonal (3 × 3=L27) at each level/spaces has been studied with respect to responses changeable (dependent factors); entrapment enhancement (X; evaluated using particle size; Y). All through experimentally performed runs, the results showed independent variables effect individually or simultaneously on changeable (dependent) variables. It also predicted significant variable via its "better to best" optimized spaces (independent level) and would be considered as novel statistically advanced oral drug delivery vehicle for anti-hypertensive agents.
authors: Research Scholar, Department of RIC, IKG Punjab Technical University, Kapurthala, Punjab, India.
authors: Permender
authors: P
authors: Rathee
authors: Chandigarh Group of Colleges, Landran, Punjab, India.
authors: Anjoo
authors: A
authors: Kamboj
authors: Department of Life Sciences and Technology, IKG Punjab Technical University, Kapurthala, Punjab, India. Electronic address: sidhushabir@rediffmail.com.
authors: Shabir
authors: S
authors: Sidhu
mesh_terms: D000959:Antihypertensive Agents / Q000737:chemistry / Q000493:pharmacokinetics; D001682:Biological Availability; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D065546:Drug Liberation; D007700:Kinetics; D008962:Models, Theoretical; D015737:Nisoldipine / Q000737:chemistry*; D010316:Particle Size
chemical_list: D000959:Antihypertensive Agents; D004337:Drug Carriers; D015737:Nisoldipine
keywords: Development; Nano-bioenhancers; Nisolodipine; Optimization; PLGA; Statistical array