title: Influence of H. pylori CagA Coupled with Alcohol Consumption on Cytokine Profiles in Men.
abstract: The aim of this study was to evaluate the effect of Helicobacter pylori (H pylori) cytotoxin-associated gene A (CagA) coupled with chronic alcohol ingestion on cytokine profiles.A total of 215 male subjects were divided into the following 4 groups: 130 alcohol H pylori CagA-negative consumers (CagA-) (group A), 50 alcohol H pylori CagA-positive consumers (CagA+) (group B), 24 nonalcohol H pylori CagA-negative consumers (group C), and 11 nonalcohol H pylori CagA-positive consumers (group D). The serum CagA, C-reactive protein (CRP), interleukin (IL)-6, IL-10, E-selectin, adiponectin (ADP), and tumor necrosis factor-α (TNF-α) levels were measured through enzyme-linked immunosorbent assays (ELISAs).After adjusting for age and mean alcohol drinking history, a multivariable linear regression analysis revealed that the mean daily alcohol consumption, IL-6, TNF-α, and ADP levels were significantly increased with increases in the serum CagA concentrations (P = 0.008, P = 0.000, P = 0.000, and P = 0.006, respectively). The serum IL-6 and IL-10 levels of group A were significantly lower than those of group B (all P = 0.000). Furthermore, the serum IL-6 and IL-10 levels of groups A and C were significantly lower than those of group D (all P = 0.000), and the serum IL-6 and IL-10 levels of group C were significantly lower than those of group B (all P = 0.000). The serum ADP and E-selectin levels of groups B and D were significantly higher than those of group A (P = 0.000). The serum ADP levels of group B were significantly higher than those of group C (P = 0.000), and the serum ADP and E-selectin levels of group C were significantly lower than those of group D (P = 0.000 and P = 0.005, respectively). Finally, the serum TNF-α levels of groups B, C, and D were significantly higher than those of group A (all P = 0.000), and the serum TNF-α levels of group C were significantly higher than those of group D (P = 0.005).In conclusion, H pylori CagA may result in significantly higher levels of several inflammatory markers in both alcohol consumers and nonalcohol consumers. However, chronic alcohol ingestion coupled with H pylori CagA positivity does not result in significant changes in cytokine profiles.
authors: From the Department of Gastroenterology, Taishan Hospital, Taian, Shandong, PR China; and Taishan Medical College, Taian, Shandong, PR China.
authors: Baoge
authors: B
authors: Qu
authors: Xinghai
authors: X
authors: Han
authors: Guangying
authors: G
authors: Ren
authors: Yiguo
authors: Y
authors: Jia
authors: Yuanxun
authors: Y
authors: Liu
authors: Jiliang
authors: J
authors: Su
authors: Zhongdong
authors: Z
authors: Wang
authors: Yafei
authors: Y
authors: Wang
authors: Hui
authors: H
authors: Wang
authors: Jindun
authors: J
authors: Pan
authors: Li-Li
authors: LL
authors: Liu
authors: Wen-Juan
authors: WJ
authors: Hu
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000097:blood*; D000942:Antigens, Bacterial / Q000097:blood*; D001426:Bacterial Proteins / Q000097:blood*; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D016207:Cytokines; C080866:cagA protein, Helicobacter pylori