title: Recent vaccine technology in industrial animals.
abstract: Various new technologies have been applied for developing vaccines against various animal diseases. Virus-like particle (VLP) vaccine technology was used for manufacturing the porcine circovirus type 2 and RNA particle vaccines based on an alphavirus vector for porcine epidemic diarrhea (PED). Although VLP is classified as a killed-virus vaccine, because its structure is similar to the original virus, it can induce long-term and cell-mediated immunity. The RNA particle vaccine used a Venezuela equine encephalitis (VEE) virus gene as a vector. The VEE virus partial gene can be substituted with the PED virus spike gene. Recombinant vaccines can be produced by substitution of the target gene in the VEE vector. Both of these new vaccine technologies made it possible to control the infectious disease efficiently in a relatively short time.
authors: Optipharm, Inc., Cheongju, Korea.
authors: Hyunil
authors: 0000-0001-9313-1322
authors: H
authors: Kim
authors: Biopharmaceutical Policy Division, Ministry of Food & Drug Safety, Cheongju, Korea.
authors: Yoo-Kyoung
authors: 0000-0002-5639-8754
authors: YK
authors: Lee
authors: Optipharm, Inc., Cheongju, Korea.
authors: Sang Chul
authors: 0000-0003-2845-981X
authors: SC
authors: Kang
authors: Optipharm, Inc., Cheongju, Korea.
authors: Beom Ku
authors: 0000-0002-4406-6226
authors: BK
authors: Han
authors: Optipharm, Inc., Cheongju, Korea.
authors: Ki Myung
authors: 0000-0003-1330-0662
authors: KM
authors: Choi
keywords: Porcine circovirus; Porcine epidemic diarrhea virus; Vaccines; Venezuelan equine encephalitis virus; Virus-like particle vaccines