title: The relationships among the levels of oxidative and antioxidative parameters, FEV1 and prolidase activity in COPD.
abstract: BACKGROUND
  Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by poorly reversible airflow limitations associated with an abnormal inflammatory response of the lung.
  
  
  METHODS
  We investigated whether prolidase levels in serum, total antioxidant status, total oxidative status (TOS), and the oxidative stress index (OSI) were associated with the etiopathogenesis of COPD, and whether there is a relationship between prolidase activity and oxidative parameters and carotid artery intima-media thickness (CIMT) in patients with COPD. This study included 91 patients with COPD and 15 control cases. Routine haematological and biochemical parameters were determined in all patients. All subjects were fully informed about the study and provided consent.
  
  
  RESULTS
  The mean age of the patients with COPD was 61.3 ± 10.5 years and that of the control group was 56.2 ± 12.1 years. The control group had a significantly higher plasma prolidase level than that in the COPD group. TOS and OSI levels in the control group were significantly lower than those in the COPD group. However, no significant differences were found in TALs or CIMT levels between the COPD and control groups. A negative correlation was detected between prolidase activity and age; however, no significant difference in age was observed between the two groups.
  
  
  CONCLUSIONS
  These results indicate that prolidase activity decreases in patients with COPD.
authors: a Yuzuncu Yıl University, Pulmonary Medicine , 65080 Van , Turkey.
authors: Selami
authors: S
authors: Ekin
authors: a Yuzuncu Yıl University, Pulmonary Medicine , 65080 Van , Turkey.
authors: Ahmet
authors: A
authors: Arısoy
authors: a Yuzuncu Yıl University, Pulmonary Medicine , 65080 Van , Turkey.
authors: Hulya
authors: H
authors: Gunbatar
authors: a Yuzuncu Yıl University, Pulmonary Medicine , 65080 Van , Turkey.
authors: Bunyamin
authors: B
authors: Sertogullarindan
authors: a Yuzuncu Yıl University, Pulmonary Medicine , 65080 Van , Turkey.
authors: Aysel
authors: A
authors: Sunnetcioglu
authors: b Department of Biochemistry , Harran University , Turkey.
authors: Hatice
authors: H
authors: Sezen
authors: a Yuzuncu Yıl University, Pulmonary Medicine , 65080 Van , Turkey.
authors: Selvi
authors: S
authors: Asker
authors: c Private Lokman Hekim Hospital , Pulmonary Medicine , Turkey.
authors: Hanifi
authors: H
authors: Yıldız
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D004150:Dipeptidases / Q000097:blood* / Q000378:metabolism; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology
chemical_list: D000975:Antioxidants; D004150:Dipeptidases; C022449:proline dipeptidase
keywords: COPD; Oxidative stress; Prolidase