title: [Investigation of the antioxidant activity and cardioprotective effect of reamberin and cytoflavin in newborn rats exposed to chronic hemic hypoxia].
abstract: The authors analyzed the antioxidant activity of reamberin and cytoflavin and evaluated their cardioprotective effect, by investigating lipid peroxidation and oxidative modification of plasma proteins, as well as the ultrastructure of newborn rat cardiomyocytes under chronic hemic hypoxia induced by sodium nitrite. Reamberin and cytoflavin can reduce the manifestations of mitochondrial dysfunction and the degree of cardiomyocyte damage in the neonatal rats due to the antioxidant and membrane-protective properties of the drugs. Succinic acid in combination with the metabolic components of the drugs significantly inhibits lipid peroxidation, by improving the structure of membranes and the mitochondrial function of cardiomyocytes.
authors: S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Republic of Crimea, Russia.
authors: I V
authors: IV
authors: Zadnipryanyi
authors: S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Republic of Crimea, Russia.
authors: O S
authors: OS
authors: Tretyakova
authors: S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Republic of Crimea, Russia.
authors: T P
authors: TP
authors: Sataeva
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D001798:Blood Proteins / Q000378:metabolism; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D004338:Drug Combinations; D005486:Flavin Mononucleotide / Q000008:administration & dosage*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007290:Inosine Diphosphate / Q000008:administration & dosage*; D015227:Lipid Peroxidation / Q000187:drug effects; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology; D009536:Niacinamide / Q000008:administration & dosage*; D051381:Rats; D012977:Sodium Nitrite / Q000633:toxicity; D013386:Succinates / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D001798:Blood Proteins; D002316:Cardiotonic Agents; D004338:Drug Combinations; C549374:Reamberin; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D008536:Meglumine; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D012977:Sodium Nitrite