title: The relationship between chronic obstructive pulmonary disease and transcatheter aortic valve implantation--A systematic review and meta-analysis.
abstract: OBJECTIVE
  The present study was performed to investigate the relationship between chronic obstructive pulmonary disease (COPD) and transcatheter aortic valve implantation (TAVI).
  
  
  BACKGROUND
  Controversies regarding the relationship between COPD and TAVI have intensified.
  
  
  METHODS
  A literature review of the PubMed online database was performed, and articles published between January 1, 2002 and March 20, 2015 were analyzed. Random-effect and fixed-effect models were used, depending on the between-study heterogeneity.
  
  
  RESULTS
  A total of 28 studies, involving 51,530 patients, were identified in our review. The burden of COPD ranged from 12.5% to 43.4%, and COPD negatively impacted both short-term and long-term all-cause survival (30 days: odds ratio [OR], 1.43, 95% CI, 1.14-1.79; >2 years: hazard ratio [HR], 1.34, 95% CI, 1.12-1.61). COPD was also associated with increased short-term and mid-term cardiac-cause mortality (30 days: OR, 1.29, 95% CI, 1.02-1.64; 1 year: HR: 1.09, 1.02-1.17). Moreover, COPD (OR, 1.97, 95% CI, 1.29-3.0) predicted post-TAVI acute kidney disease. Importantly, chronic kidney disease (CKD) (HR, 1.2, 95% CI, 1.1-1.32) and the distance of the 6 minute walk test (6MWT) (HR, 1.16, 1.06-1.27) predicted TAVI futility in patients with COPD.
  
  
  CONCLUSIONS
  COPD is common among patients undergoing TAVI, and COPD impacts both short- and long-term survival. COPD patients, who had a lower BMI, shorter distance of 6MWT and CKD, were at higher risk for TAVI futility.
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic China.
authors: Yan-Biao
authors: YB
authors: Liao
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic China.
authors: Ze-Xia
authors: ZX
authors: He
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic China.
authors: Zhen-Gang
authors: ZG
authors: Zhao
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic China.
authors: Xin
authors: X
authors: Wei
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic China.
authors: Zhi-Liang
authors: ZL
authors: Zuo
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic China.
authors: Yi-Jian
authors: YJ
authors: Li
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic China.
authors: Tian-Yuan
authors: TY
authors: Xiong
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic China.
authors: Yuan-Ning
authors: YN
authors: Xu
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic China.
authors: Yuan
authors: Y
authors: Feng
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic China.
authors: Mao
authors: M
authors: Chen
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D015992:Body Mass Index; D006328:Cardiac Catheterization / Q000295:instrumentation / Q000379:methods* / Q000401:mortality; D016009:Chi-Square Distribution; D015897:Comorbidity; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods* / Q000401:mortality; D006801:Humans; D016015:Logistic Models; D008168:Lung / Q000503:physiopathology; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D016138:Walking
keywords: aortic stenosis; chronic obstructive pulmonary disease; transcatheter aortic valve