title: Association between drug intake and incidence of malignancies in patients with Juvenile Idiopathic Arthritis: a nested case-control study.
abstract: BACKGROUND
  Several medications for treatment of Juvenile Idiopathic Arthritis (JIA) are considered to be carcinogenic. Therefore, the aim was to assess whether there is an association between therapeutic interventions and malignancies in JIA patients.
  
  
  RESULTS
  A nested case-control study was carried out within a retrospective cohort study of 3698 JIA patients diagnosed between 1952 and 2010. All 48 JIA patients with a diagnosis of a malignant tumour and up to four matched controls for each received a questionnaire about their use of medication. Subsequently treatment was compared between cases and controls and analyses performed for 37 cases and 125 controls (response 88.5 %). Treatment with DMARD (84 %) was most frequently used, followed by glucocorticoids (66 %) and immunosuppressives (65 %). Twenty percent reported to have ever been taking biologics. Medication use did not differ significantly between cases and controls.
  
  
  CONCLUSIONS
  Our results did not show an association between medications used and malignancies in JIA patients.
authors: Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich (Ludwig-Maximilans-University), Ziemssenstr.1, 80337, Munich, Germany. Swaantje.Barth@gmail.com.
authors: Swaantje
authors: S
authors: Barth
authors: Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich (Ludwig-Maximilans-University), Ziemssenstr.1, 80337, Munich, Germany. Jenny.Schlichtiger@med.uni-muenchen.de.
authors: Jenny
authors: J
authors: Schlichtiger
authors: Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich (Ludwig-Maximilans-University), Ziemssenstr.1, 80337, Munich, Germany. Betty.Bisdorff@med.uni-muenchen.de.
authors: Betty
authors: B
authors: Bisdorff
authors: German Center for Pediatric and Adolescent Rheumatology, Gehfeldstraße 24, 82467, Garmisch-Partenkirchen, Germany. Huegle.Boris@rheuma-kinderklinik.de.
authors: Boris
authors: B
authors: Hügle
authors: German Center for Pediatric and Adolescent Rheumatology, Gehfeldstraße 24, 82467, Garmisch-Partenkirchen, Germany. michels.garmisch-partenkirchen@t-online.de.
authors: Hartmut
authors: H
authors: Michels
authors: Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich (Ludwig-Maximilans-University), Ziemssenstr.1, 80337, Munich, Germany. Sekretariat-Radon@med.uni-muenchen.de.
authors: Katja
authors: K
authors: Radon
authors: German Center for Pediatric and Adolescent Rheumatology, Gehfeldstraße 24, 82467, Garmisch-Partenkirchen, Germany. haas.johannes-peter@rheuma-kinderklinik.de.
authors: Johannes-Peter
authors: JP
authors: Haas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000150:complications* / Q000188:drug therapy; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D018501:Antirheumatic Agents