title: MACEs Not Associated With the Use of Biologic Therapy for Psoriasis in Real-World Clinical Practice: A Canadian Multicenter Retrospective Study.
abstract: BACKGROUND
  Previous reports have shown inconsistent findings with regard to the relationship between biologic therapy and risk for major adverse cardiovascular events (MACEs).
  
  
  OBJECTIVE
  The aim of this study was to determine the overall rate of MACEs in a cohort of 398 patients.
  
  
  METHODS
  All patients treated with biologics for psoriasis at 2 academic centers in Toronto, Ontario, between September 2005 and September 2014 were considered for inclusion. Medical records were reviewed to identify MACEs.
  
  
  RESULTS
  A total of 398 patients were included. The median duration of disease was 19.8 years. Median time to biologic therapy withdrawal because of an adverse event was 23.5 months. In this cohort, no MACEs were identified in patients treated with biologic therapy.
  
  
  CONCLUSIONS
  Biologic treatment for psoriasis was not associated with increased cardiovascular risk in this cohort. These results require validation in larger studies.
authors: Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
authors: Whan B
authors: WB
authors: Kim
authors: School of Medicine, University of Toronto, Toronto, ON, Canada.
authors: Judy
authors: J
authors: Qiang
authors: Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada Sunnybrook Health Sciences Centre, Toronto, ON, Canada Women's College Hospital, Toronto, ON, Canada jensen.yeung@utoronto.ca.
authors: Jensen
authors: J
authors: Yeung
mesh_terms: D001688:Biological Products / Q000009:adverse effects*; D001691:Biological Therapy / Q000009:adverse effects*; D002170:Canada; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D012189:Retrospective Studies
chemical_list: D001688:Biological Products
keywords: biologic; mace; psoriasis