title: Association of IL23R polymorphism (rs7530511) with intracerebral hemorrhage in Korean population.
abstract: Cytokines and their receptors are involved in the development of intracerebral hemorrhage (ICH). Interleukin 23 receptor (IL23R) has been implicated in numerous inflammatory and immune diseases. In this study, we investigated whether single nucleotide polymorphisms (SNPs) of IL23R were associated with the susceptibility of ICH in Korean population. Two coding region SNPs (cSNPs) [rs1884444 (Gln3His), and rs7530511 (Leu310Pro)] were selected, and genotyped in 167 ICH patients and 377 control subjects using direct sequencing. Of two cSNPs, only rs7530511 showed a significant association with ICH in codominant model (C/T vs. C/C, P = 0.017, odds ratio (OR) 4.15, 95 % confidential interval (CI) 1.27-13.58). Allele frequency analysis also revealed that rs7530511 was associated with ICH (P = 0.023, OR 3.68, 95 % CI 1.19-11.32). The frequency of the T allele was increased in the ICH patients, compared to the control subjects. These results suggest that IL23R may contribute to the development of ICH.
authors: Kohwang Medical Research Institute, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul, 130-701, South Korea.
authors: Hae Jeong
authors: HJ
authors: Park
authors: Kohwang Medical Research Institute, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul, 130-701, South Korea.
authors: Su Kang
authors: SK
authors: Kim
authors: Department of Emergency Medicine, School of Medicine, Kyung Hee University, Seoul, 130-701, South Korea.
authors: Hyun-Kyung
authors: HK
authors: Park
authors: Kohwang Medical Research Institute, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul, 130-701, South Korea. jhchung@khu.ac.kr.
authors: Joo-Ho
authors: JH
authors: Chung
mesh_terms: D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D056910:Republic of Korea
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin
keywords: Interleukin 23 receptor; Intracerebral hemorrhage; Single nucleotide polymorphism