title: The effect of antenatal lifestyle advice for women who are overweight or obese on secondary measures of neonatal body composition: the LIMIT randomised trial.
abstract: OBJECTIVE
  To evaluate the effect of providing antenatal dietary and lifestyle advice on neonatal anthropometry, and to determine the inter-observer variability in obtaining anthropometric measurements.
  
  
  METHODS
  Randomised controlled trial.
  
  
  METHODS
  Public maternity hospitals across metropolitan Adelaide, South Australia.
  
  
  METHODS
  Pregnant women with a singleton gestation between 10(+0) and 20(+0) weeks, and body mass index (BMI) ≥25 kg/m(2).
  
  
  METHODS
  Women were randomised to either Lifestyle Advice (comprehensive dietary and lifestyle intervention over the course of pregnancy including dietary, exercise and behavioural strategies, delivered by a research dietician and research assistants) or continued Standard Care. Analyses were conducted using intention-to-treat principles.
  
  
  METHODS
  Secondary outcome measures for the trial included assessment of infant body composition using body circumference and skinfold thickness measurements (SFTM), percentage body fat, and bio-impedance analysis of fat-free mass.
  
  
  RESULTS
  Anthropometric measurements were obtained from 970 neonates (488 Lifestyle Advice Group, and 482 Standard Care Group). In 394 of these neonates (215 Lifestyle Advice Group, and 179 Standard Care Group) bio-impedance analysis was also obtained. There were no statistically significant differences identified between those neonates born to women receiving Lifestyle Advice and those receiving Standard Care, in terms of body circumference measures, SFTM, percentage body fat, fat mass, or fat-free mass. The intra-class correlation coefficient for SFTM was moderate to excellent (0.55-0.88).
  
  
  CONCLUSIONS
  Among neonates born to women who are overweight or obese, anthropometric measures of body composition were not modified by an antenatal dietary and lifestyle intervention.
authors: Discipline of Obstetrics and Gynaecology, The Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.|Women's and Babies Division, Department of Perinatal Medicine, The Women's and Children's Hospital, North Adelaide, SA, Australia.
authors: J M
authors: JM
authors: Dodd
authors: Discipline of Obstetrics and Gynaecology, The Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.
authors: A R
authors: AR
authors: Deussen
authors: Discipline of Obstetrics and Gynaecology, The Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.
authors: I
authors: I
authors: Mohamad
authors: Obesity Prevention Program, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
authors: S L
authors: SL
authors: Rifas-Shiman
authors: Women's and Children's Health Research Institute, North Adelaide, SA, Australia.|School of Population Health, The University of Adelaide, Adelaide, SA, Australia.
authors: L N
authors: LN
authors: Yelland
authors: School of Population Health, The University of Adelaide, Adelaide, SA, Australia.
authors: J
authors: J
authors: Louise
authors: Women's and Babies Division, Department of Neonatal Medicine, The Women's and Children's Hospital, Adelaide, SA, Australia.
authors: A J
authors: AJ
authors: McPhee
authors: Discipline of Obstetrics and Gynaecology, The Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.|Women's and Babies Division, Department of Perinatal Medicine, The Women's and Children's Hospital, North Adelaide, SA, Australia.
authors: R M
authors: RM
authors: Grivell
authors: Discipline of Obstetrics and Gynaecology, The Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.
authors: J A
authors: JA
authors: Owens
authors: Obesity Prevention Program, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
authors: M W
authors: MW
authors: Gillman
authors: Discipline of Obstetrics and Gynaecology, The Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.
authors: J S
authors: JS
authors: Robinson
mesh_terms: D000328:Adult; D001823:Body Composition; D037001:Directive Counseling / Q000379:methods*; D005247:Feeding Behavior / Q000523:psychology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008019:Life Style; D009520:New Zealand / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology / Q000517:prevention & control* / Q000523:psychology; D018743:Perinatal Care / Q000379:methods*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000517:prevention & control* / Q000523:psychology; D037841:Pregnant People / Q000523:psychology*; D013021:South Australia / Q000453:epidemiology; D016896:Treatment Outcome; D015430:Weight Gain
keywords: Antenatal dietary and lifestyle intervention; neonatal anthropometry; randomised trial; skinfold thickness measurements