title: Postural Orthostatic Tachycardia Syndrome (POTS)--A novel member of the autoimmune family.
abstract: Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous disorder of the autonomic nervous system in which a change from the supine position to an upright position causes an abnormally large increase in heart rate or tachycardia (30 bpm within 10 min of standing or head-up tilt). This response is accompanied by a decrease in blood flow to the brain and hence a spectrum of symptoms associated with cerebral hypoperfusion. Many of these POTS-related symptoms are also observed in chronic anxiety and panic disorders, and therefore POTS is frequently under- and misdiagnosed.
authors: Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors: S
authors: S
authors: Dahan
authors: Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
authors: L
authors: L
authors: Tomljenovic
authors: Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Israel Shoenfel@post.tau.ac.il.
authors: Y
authors: Y
authors: Shoenfeld
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology; D015551:Autoimmunity; D036022:Capsid Proteins / Q000276:immunology; D002560:Cerebrovascular Circulation; D003429:Cross Reactions; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D006339:Heart Rate; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000276:immunology; D053918:Papillomavirus Vaccines / Q000276:immunology; D054972:Postural Orthostatic Tachycardia Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology; D012307:Risk Factors; D016683:Supine Position
chemical_list: D036022:Capsid Proteins; D009856:Oncogene Proteins, Viral; D053918:Papillomavirus Vaccines; C063317:L1 protein, Human papillomavirus type 16
keywords: Postural orthostatic tachycardia syndrome (POTS); autoantibodies; autoimmunity; chronic fatigue syndrome (CFS); human papilloma virus (HPV); molecular mimicry