title: Visual Field Change and 24-Hour IOP-Related Profile with a Contact Lens Sensor in Treated Glaucoma Patients.
abstract: OBJECTIVE
  To test the hypothesis that a 24-hour recording of intraocular pressure (IOP)-related measurements derived from a contact lens sensor (CLS) correlates to the rate of visual field progression in treated glaucomatous eyes.
  
  
  METHODS
  Prospective, cross-sectional study.
  
  
  METHODS
  Forty treated glaucomatous patients with 8 or more 24-2 visual field tests.
  
  
  METHODS
  Twenty-four-hour recording with a CLS that provides IOP-related measurements.
  
  
  METHODS
  Rates of visual field mean deviation (MD) change before and at the time of CLS recording and CLS parameters, namely number of large peaks, mean peak ratio, wake-to-sleep slope, amplitude and area under the cosine curve, and variability from the mean.
  
  
  RESULTS
  When comparing the rate of MD change before and at the time of CLS recording of all patients, the average slope was -0.05 dB/year faster in the beginning compared with the end (P = 0.087), suggesting a deceleration of progression by the time of CLS recording. The number of long peaks and the mean peak ratio when patients were awake were the best predictors of faster progression. The combination of CLS parameters provided better measures of goodness of fit than Goldmann IOP parameters (mean, peak, and fluctuation) in the same period.
  
  
  CONCLUSIONS
  Intraocular pressure-related parameters obtained with 24-hour recording with a CLS were associated with the rate of visual field progression in treated glaucomatous eyes. This technology may be useful in detecting eyes at higher risk of glaucoma progression while receiving treatment.
authors: Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York. Electronic address: cvd2109@columbia.edu.
authors: Carlos Gustavo
authors: CG
authors: De Moraes
authors: Department of Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.
authors: Jessica V
authors: JV
authors: Jasien
authors: Sensimed AG, Lausanne, Switzerland.
authors: Sonja
authors: S
authors: Simon-Zoula
authors: Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York.
authors: Jeffrey M
authors: JM
authors: Liebmann
authors: Department of Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.
authors: Robert
authors: R
authors: Ritch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002940:Circadian Rhythm / Q000502:physiology*; D003261:Contact Lenses; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D011446:Prospective Studies; D013686:Telemetry / Q000295:instrumentation; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*
chemical_list: D000959:Antihypertensive Agents