title: Circulating memory T follicular helper subsets, Tfh2 and Tfh17, participate in the pathogenesis of Guillain-Barré syndrome.
abstract: Circulating memory T follicular helper subsets, Tfh2 and Tfh17 are found to be aberrantly regulated in many autoimmune diseases. However, their roles in the pathogenesis of GBS are still unclear. This study examined the phenotype, distribution, clinical relevance and potential function of Tfh2 and Tfh17 in 36 GBS patients (including 24 AMAN and 12 AIDP patients). We found that the absolute counts of total memory Tfh cells were significantly increased in AMAN, while no significant difference in AIDP compared with HC. Furthermore, the levels of the three subsets of memory Tfh cells, Tfh1, Tfh2 and Tfh17, were differentially altered in AMAN. The absolute counts of Tfh1, Tfh2 and Tfh17 were all increased to a higher level in AMAN. The ratio of (Tfh2+Tfh17)/Tfh1 and the percentages of ICOS(+) cells in Tfh2 and Tfh17 cells were greater in AMAN when compared to AIDP and HC, and the former had a positive correlation with the severity of both AMAN and AIDP. Conversely, the percentages of PD1(+) cells in Tfh2 and Tfh17 cells were lower in AMAN than in HC. Therefore, circulating memory Tfh2 and Tfh17 cells might promote the autoantibody-related immune response and serve as useful markers to evaluate the progression of AMAN.
authors: Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China.
authors: Yuanyuan
authors: Y
authors: Che
authors: Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China.
authors: Jinpeng
authors: J
authors: Qiu
authors: Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China.
authors: Tao
authors: T
authors: Jin
authors: Department of Neurology, The Second Hospital of Jilin University, Changchun 130021, China.
authors: Fei
authors: F
authors: Yin
authors: Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China.
authors: Man
authors: M
authors: Li
authors: Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China.|Key Laboratory of Zoonoses Research, Ministry of Education, The First Hospital of Jilin University, Changchun 130021, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.
authors: Yanfang
authors: Y
authors: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007156:Immunologic Memory; D016130:Immunophenotyping; D060889:Inducible T-Cell Co-Stimulator Protein / Q000235:genetics / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D061026:Programmed Cell Death 1 Receptor / Q000235:genetics / Q000276:immunology; D012720:Severity of Illness Index; D018417:Th1 Cells / Q000276:immunology / Q000473:pathology*; D058504:Th17 Cells / Q000276:immunology / Q000473:pathology*; D018418:Th2 Cells / Q000276:immunology / Q000473:pathology*
chemical_list: D001323:Autoantibodies; C556692:ICOS protein, human; D060889:Inducible T-Cell Co-Stimulator Protein; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor