title: Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women.
abstract: OBJECTIVE
  We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women.
  
  
  METHODS
  Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. A repeated measures logistic regression model was used where the outcomes were recorded at 5, 10, 15 and 20-years follow-up.
  
  
  RESULTS
  The highest quartile of sCOMP was associated with increased risk of RKOA with overall OR of 1.97 (95% CI: 1.33-2.91) over 20 years when compared with the lowest sCOMP quartile. The association with painful KOA was similar and also independent, but only when the fourth and third sCOMP quartiles were compared.
  
  
  CONCLUSIONS
  This study demonstrates that sCOMP levels are predictive of subsequent structural changes and incidence of painful KOA, independently of age and BMI.
authors: a Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford , UK .|b Arthritis Research UK Sports, Exercise and Osteoarthritis Centre of Excellence, University of Oxford , Oxford , UK .
authors: Stefan
authors: S
authors: Kluzek
authors: c Nordic Bioscience Biomarkers and Research , Herlev , Denmark .
authors: Anne-Christine
authors: AC
authors: Bay-Jensen
authors: a Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford , UK .|d MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital , Southampton , UK .
authors: Andrew
authors: A
authors: Judge
authors: c Nordic Bioscience Biomarkers and Research , Herlev , Denmark .
authors: Morten A
authors: MA
authors: Karsdal
authors: e Medical Sciences Division, University of Oxford , Oxford , UK , and.
authors: Matthew
authors: M
authors: Shorthose
authors: f Department of Twin Research and Genetic Epidemiology , King's College London , London , UK.
authors: Tim
authors: T
authors: Spector
authors: f Department of Twin Research and Genetic Epidemiology , King's College London , London , UK.
authors: Deborah
authors: D
authors: Hart
authors: b Arthritis Research UK Sports, Exercise and Osteoarthritis Centre of Excellence, University of Oxford , Oxford , UK .
authors: Julia L
authors: JL
authors: Newton
authors: a Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford , UK .|b Arthritis Research UK Sports, Exercise and Osteoarthritis Centre of Excellence, University of Oxford , Oxford , UK .|d MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital , Southampton , UK .
authors: Nigel K
authors: NK
authors: Arden
mesh_terms: D018771:Arthralgia / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D064236:Cartilage Oligomeric Matrix Protein / Q000097:blood*; D018450:Disease Progression; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000378:metabolism*; D016015:Logistic Models; D008137:Longitudinal Studies; D008875:Middle Aged; D016017:Odds Ratio; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D010147:Pain Measurement; D011237:Predictive Value of Tests; D011859:Radiography; D012307:Risk Factors; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; C577553:TSP5 protein, human
keywords: COMP; Cohort; epidemiology; knee; osteoarthritis