title: Strain-Related Differences in the Immune Response: Relevance to Human Stroke.
abstract: There are significant differences in the immune response and in the susceptibility to autoimmune diseases among rodent strains. It would thus be expected that the contribution of the immune response to cerebral ischemic injury would also differ among rodent strains. More importantly, there are significant differences between the immune responses of rodents and humans. All of these factors are likely to impact the successful translation of immunomodulatory therapies from experimental rodent models to patients with stroke.
authors: Department of Neurology, University of Washington School of Medicine, Harborview Medical Center, 325 9th Ave, Box 359775, Seattle, WA, 98104-2499, USA. kjb@uw.edu.
authors: Kyra J
authors: KJ
authors: Becker
mesh_terms: D000367:Age Factors; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans / Q000276:immunology; D012377:Rodentia / Q000276:immunology; D012737:Sex Factors; D013045:Species Specificity; D020521:Stroke / Q000276:immunology* / Q000628:therapy
chemical_list: D016207:Cytokines
keywords: EAE; Immune response; Immunology; Strain; Stroke