title: Development and Delivery of a Physical Activity Intervention for People With Huntington Disease: Facilitating Translation to Clinical Practice.
abstract: OBJECTIVE
  We studied the development and delivery of a 14-week complex physical activity intervention for people with Huntington disease, where detailed information about the intervention was fully embedded in the trial design process.
  
  
  METHODS
  Intervention Development: The intervention was developed through a series of focus groups. The findings from the focus groups informed the development of a logic model for the physical activity intervention that was broadly consistent with the framework of self-determination theory. Intervention Delivery: Key components underpinning the delivery of the intervention were implemented including a defined coach training program and intervention fidelity assessment methods. Training of coaches (physical therapists, occupational therapists, research nurses, and exercise trainers) was delivered via group and 1:1 training sessions using a detailed coach's manual, and with ongoing support via video calls, and e-mail communication as needed. Detailed documentation was provided to determine costs of intervention development and coach training.
  
  
  RESULTS
  Intervention delivery coaches at 8 sites across the United Kingdom participated in the face-to-face training. Self-report checklists completed by each of the coaches indicated that all components of the intervention were delivered in accordance with the protocol. Mean (standard deviation) intervention fidelity scores (n = 15), as measured using a purpose-developed rating scale, was 11 (2.4) (out of 16 possible points). Coaches' perceptions of intervention fidelity were similarly high. The total cost of developing the intervention and providing training was £30,773 ($47,042 USD).
  
  
  CONCLUSIONS
  An important consideration in promoting translation of clinical research into practice is the ability to convey the detailed components of how the intervention was delivered to facilitate replication if the results are favorable. This report presents an illustrative example of a physical activity intervention, including the development and the training required to deliver it. This approach has the potential to facilitate reproducibility, evidence synthesis, and implementation in clinical practice.Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A122).
authors: School of Healthcare Sciences (L.Q., M.B.), Schools of Medicine and Biosciences (A.R.), and South East Wales Trials Unit (R.T., J.T., C.D., M.K., V.P., K.H.), Cardiff University, Cardiff, United Kingdom; Department of Biobehavioral Sciences (L.Q.), Teachers College, Columbia University, New York; Wales School of Primary Care Research (N.G.), Cochrane Institute of Primary Care Research, School of Medicine, Cardiff University, Cardiff, United Kingdom; Department of Sport and Health Sciences (H.D.), Oxford Brookes University, Oxford, United Kingdom; and Centre for Health Economics and Medicines Evaluation (R.T.E., C.J.), Bangor University, Bangor, United Kingdom.
authors: Lori
authors: L
authors: Quinn
authors: Rob
authors: R
authors: Trubey
authors: Nina
authors: N
authors: Gobat
authors: Helen
authors: H
authors: Dawes
authors: Rhiannon Tudor
authors: RT
authors: Edwards
authors: Carys
authors: C
authors: Jones
authors: Julia
authors: J
authors: Townson
authors: Cheney
authors: C
authors: Drew
authors: Mark
authors: M
authors: Kelson
authors: Vincent
authors: V
authors: Poile
authors: Anne
authors: A
authors: Rosser
authors: Kerenza
authors: K
authors: Hood
authors: Monica
authors: M
authors: Busse
mesh_terms: D015444:Exercise; D005081:Exercise Therapy / Q000379:methods; D006801:Humans; D006816:Huntington Disease / Q000628:therapy*; D059825:Physical Therapists; D026741:Physical Therapy Modalities; D016896:Treatment Outcome