title: Using Cystic Fibrosis Therapies for Non-Cystic Fibrosis Bronchiectasis.
abstract: Non-cystic fibrosis bronchiectasis (NCFB) is an increasingly prevalent disease that places a significant burden on patients and health systems globally. Although many of the therapies used to treat NCFB were originally developed as cystic fibrosis (CF) therapies, not all of them have been demonstrated to be efficacious in NCFB and some may even be harmful. This article explores the evidence for which therapeutic strategies used to treat CF have been translated into the care of NCFB. The conclusion is that therapies for adult NCFB cannot be simply extrapolated from CF clinical trials, and in some instances, doing so may actually result in harm.
authors: Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, 200 West Arbor Drive, MC 8372, San Diego, CA 92013, USA.
authors: Wael
authors: W
authors: ElMaraachli
authors: Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, 200 West Arbor Drive, MC 8372, San Diego, CA 92013, USA. Electronic address: dconrad@ucsd.edu.
authors: Douglas J
authors: DJ
authors: Conrad
authors: Division of Chest and Critical Care Medicine, Scripps Clinic, 10666 North Torrey Pines Road, W203, San Diego, CA 92037, USA.
authors: Angela C C
authors: AC
authors: Wang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001987:Bronchiectasis / Q000188:drug therapy* / Q000209:etiology; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000628:therapy*; D019468:Disease Management; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans
chemical_list: D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents
keywords: Bronchiectasis; Chest medicine; Cystic fibrosis; Non–cystic fibrosis; Treatment