title: [Enzymatic Synthesis of Acidic β-Lactams (Review)].
abstract: The currently known methods of enzymatic β-lactam synthesis, as well as the enzymes and heterogeneous biocatalysts used for this purpose, are presented, and the published reports on advances in the field of enzymatic synthesis of selected antibiotics belonging to the groups of acidic penicillins and acidic cephalosporins are summarized in the present review. The key conditions and parameters of biocatalytic processes, such as the biocatalyst form, concentration of the precursor compounds, solvent type, pH, temperature, etc. are analyzed and compared, and guidelines for further optimization of β-lactam synthesis are given. The present review may be of use for a wide range of readers, as well as to enzymology and biotechnology experts.
authors: A V
authors: AV
authors: Sklyarenko
authors: M A
authors: MA
authors: EI'darov
authors: V B
authors: VB
authors: Kurochkina
authors: S V
authors: SV
authors: Yarotskii
mesh_terms: D000143:Acids; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000138:chemical synthesis*; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics; D055162:Biocatalysis; D002511:Cephalosporins / Q000096:biosynthesis / Q000138:chemical synthesis*; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000235:genetics; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D015870:Gene Expression; D006863:Hydrogen-Ion Concentration; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000235:genetics; D010399:Penicillin Amidase / Q000737:chemistry* / Q000235:genetics; D010406:Penicillins / Q000096:biosynthesis / Q000138:chemical synthesis*; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics; D012997:Solvents / Q000737:chemistry; D013696:Temperature
chemical_list: D000143:Acids; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002511:Cephalosporins; D004800:Enzymes, Immobilized; D009097:Multienzyme Complexes; D010406:Penicillins; D011994:Recombinant Proteins; D012997:Solvents; C038760:cephalosporin C synthetase system; D010399:Penicillin Amidase