title: Sedation Protocol Using Dexmedetomidine for Third Molar Extraction.
abstract: OBJECTIVE
  The aim of this study was to establish a proper sedative protocol of dexmedetomidine for outpatients.
  
  
  METHODS
  The study compared compare patients' pain, satisfaction, adverse events, and sedation depth during extraction of third molars using a sedative protocol of intravenous (IV; 1.0 μg/kg) versus intranasal (IN; 1.5 μg/kg) administration of dexmedetomidine. In total, 240 patients were randomized, 160 patients received dexmedetomidine, and data, including the amount of agent used, visual analog scale (VAS) pain score, adverse events, VAS score of patient satisfaction, and bispectral index, were recorded.
  
  
  RESULTS
  Patients in the dexmedetomidine groups reported lower VAS pain scores and higher VAS satisfaction scores than patients in the local anesthesia group. There were no statistically meaningful differences between dexmedetomidine groups. Sedation with the IV route was slightly deeper than with the IN route. However, there were no statistically meaningful differences.
  
  
  CONCLUSIONS
  IN or IV administration of dexmedetomidine is recommended as an effective, safe, and competent protocol in outpatient sedative surgeries.
authors: Resident, Department of Oral and Maxillofacial Surgery, Kyung Hee University Dental Hospital at Gangdong, Kyung Hee University, Seoul, Korea.
authors: Dae-Seung
authors: DS
authors: Ryu
authors: Associate Professor, Department of Oral and Maxillofacial Surgery, Kyung Hee University Dental Hospital at Gangdong, Kyung Hee University, Seoul, Korea. Electronic address: verycutebear@khu.ac.kr.
authors: Deok-Won
authors: DW
authors: Lee
authors: Associate Professor, Department of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
authors: Sung Chul
authors: SC
authors: Choi
authors: Assistant Professor, Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors: In-Hwan
authors: IH
authors: Oh
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D002985:Clinical Protocols; D016292:Procedural Sedation / Q000379:methods*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery*; D014081:Tooth Extraction / Q000379:methods*; D055815:Young Adult
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine