title: Effect of lanosterol on human cataract nucleus.
abstract: OBJECTIVE
  To study the effect of lanosterol on age-related cataractous human lens nuclei.
  
  
  METHODS
  Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity.
  
  
  RESULTS
  Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days.
  
  
  CONCLUSIONS
  Lanosterol 25 mM solution did not reverse opacification of human age-related cataractous nuclei.
authors: Department of Vitreoretinal Services and Ocular Oncology, Sankara Eye Hospital, Kundalahalli Gate, Bengaluru, Karnataka, India.
authors: P Mahesh
authors: PM
authors: Shanmugam
authors: Aditya
authors: A
authors: Barigali
authors: Jayant
authors: J
authors: Kadaskar
authors: Sandip
authors: S
authors: Borgohain
authors: Divaynsh Kailash Chandra
authors: DK
authors: Mishra
authors: Rajesh
authors: R
authors: Ramanjulu
authors: C K
authors: CK
authors: Minija
mesh_terms: D002386:Cataract / Q000175:diagnosis / Q000188:drug therapy*; D002387:Cataract Extraction; D003459:Crystallins / Q000187:drug effects; D018450:Disease Progression; D006801:Humans; D007810:Lanosterol / Q000494:pharmacology*; D019654:Lens Implantation, Intraocular; D007907:Lens Nucleus, Crystalline / Q000187:drug effects* / Q000473:pathology; D011446:Prospective Studies; D066263:Protein Aggregation, Pathological / Q000188:drug therapy*
chemical_list: D003459:Crystallins; D007810:Lanosterol