title: [Cutaneous ulcerating nodules after many years of immunotherapy].
abstract: A 40-year-old female patient was referred to the department of Dermatology with subcutaneous nodules and ulcers years after starting with immunotherapy injections (Purethal) for hay fever. The skin reaction appeared to be due to aluminium hydroxide, which is used as an adjuvant to many injections and vaccins. Aluminium hydroxide can cause delayed granulomatous contact dermatitis or foreign body reactions.
authors: Erasmus MC, Rotterdam.
authors: Hanneke
authors: H
authors: Bouten
authors: Tamar E C
authors: TE
authors: Nijsten
authors: Vincent
authors: V
authors: Noordhoek Hegt
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects; D000328:Adult; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D007271:Injections, Intradermal; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology*
chemical_list: D000276:Adjuvants, Immunologic; D000536:Aluminum Hydroxide