title: Leptin levels in patients with anorexia nervosa following day/inpatient treatment do not predict weight 1 year post-referral.
abstract: Elevated serum leptin levels following rapid therapeutically induced weight gain in anorexia nervosa (AN) patients are discussed as a potential biomarker for renewed weight loss as a result of leptin-related suppression of appetite and increased energy expenditure. This study aims to analyze the predictive value of leptin levels at discharge as well as the average rate of weight gain during inpatient or day patient treatment for body weight at 1-year follow-up. 121 patients were recruited from the longitudinal Anorexia Nervosa Day patient versus Inpatient (ANDI) trial. Serum leptin levels were analyzed at referral and discharge. A multiple linear regression analysis to predict age-adjusted body mass index (BMI-SDS) at 1-year follow-up was performed. Leptin levels, the average rate of weight gain, premorbid BMI-SDS, BMI-SDS at referral, age and illness duration were included as independent variables. Neither leptin levels at discharge nor rate of weight gain significantly predicted BMI-SDS at 1-year follow-up explaining only 1.8 and 0.4 % of the variance, respectively. According to our results, leptin levels at discharge and average rate of weight gain did not exhibit any value in predicting weight at 1-year follow-up in our longitudinal observation study of adolescent patients with AN. Thus, research should focus on other potential factors to predict weight at follow-up. As elevated leptin levels and average rate of weight gain did not pose a risk for reduced weight, we found no evidence for the beneficial effect of slow refeeding in patients with acute AN.
authors: Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH University Aachen, Neuenhofer Weg 21, 52074, Aachen, Germany. jseitz@ukaachen.de.
authors: Jochen
authors: J
authors: Seitz
authors: Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH University Aachen, Neuenhofer Weg 21, 52074, Aachen, Germany.
authors: Katharina
authors: K
authors: Bühren
authors: Institute for Clinical Chemistry and Pathochemistry, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
authors: Ronald
authors: R
authors: Biemann
authors: Institute of Medical Biometry and Epidemiology, Philipps-University Marburg, Marburg, Germany.
authors: Nina
authors: N
authors: Timmesfeld
authors: Institute of Medical Informatics and Statistics, University Hospital Schleswig-Holstein, Christian Albrecht-University, Kiel, Germany.
authors: Astrid
authors: A
authors: Dempfle
authors: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
authors: Sibylle Maria
authors: SM
authors: Winter
authors: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany.
authors: Karin
authors: K
authors: Egberts
authors: Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Medical Centre Freiburg, Freiburg, Germany.
authors: Christian
authors: C
authors: Fleischhaker
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, Kliniken der Stadt Köln, Cologne, Germany.
authors: Christoph
authors: C
authors: Wewetzer
authors: Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH University Aachen, Neuenhofer Weg 21, 52074, Aachen, Germany.
authors: Beate
authors: B
authors: Herpertz-Dahlmann
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Essen, Germany.
authors: Johannes
authors: J
authors: Hebebrand
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Essen, Germany.
authors: Manuel
authors: M
authors: Föcker
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D002648:Child; D005260:Female; D006801:Humans; D007297:Inpatients; D020738:Leptin / Q000097:blood*; D010351:Patient Discharge; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D015430:Weight Gain / Q000502:physiology*
chemical_list: D015415:Biomarkers; D020738:Leptin
keywords: Anorexia nervosa; Follow-up; Leptin; Prognosis; Rate of weight gain