title: Effects of Femtosecond Laser-Assisted Cataract Pretreatment on Pupil Diameter: A Comparison Between Three Laser Platforms.
abstract: OBJECTIVE
  To assess pupil diameter before and after femtosecond laser-assisted cataract surgery (FLACS) pretreatment and compare the outcomes of three laser platforms.
  
  
  METHODS
  This prospective observational case series included consecutive patients scheduled to undergo cataract extraction using FLACS between August 2013 and February 2015. All eyes received FLACS pretreatment using three laser platforms: LenSx (Alcon Laboratories, Inc., Fort Worth, TX), Catalys (Abbott Medical Optics Inc., Santa Ana, CA), and Victus (Bausch & Lomb, Inc., Rochester, NY). The same protocol for preoperative medical mydriasis was used for all patients, and pupil diameter was assessed immediately before and 3 minutes after FLACS using a surgical ruler.
  
  
  RESULTS
  A total of 198 eyes of 161 patients were included in the study. Mean pupillary miosis was 1.42 ± 1.26 mm for the LenSx, 0.66 ± 0.89 mm for the Catalys, and 0.14 ± 0.34 mm for the Victus groups. Furthermore, 8 of the 198 eyes (4.0%) demonstrated a pupil diameter of less than 5 mm after FLACS and 48 eyes (24.24%) demonstrated a pupil diameter of 6 mm or less. There was a statistically significant decrease in pupil diameter for all groups individually (P < .05). There was also a statistically significant difference among the three groups (P < .05), with LenSx inducing the highest degree of miosis, followed by Catalys, and finally Victus. A correlation between the pupil diameter before FLACS and degree of FLACS-induced miosis was demonstrated (P < .05), with larger pupil diameter before FLACS associated with greater miosis.
  
  
  CONCLUSIONS
  FLACS pretreatment seems to induce significant pupillary miosis with all laser platforms assessed in this study. The decrease in pupil diameter after FLACS reached clinical significance for cataract extraction (< 5 mm) in 4.0% of cases, whereas 20.2% of eyes demonstrated small pupil diameter (≤ 6 mm) after FLACS pretreatment.
authors: Vasilios F
authors: VF
authors: Diakonis
authors: Nilufer
authors: N
authors: Yesilirmak
authors: Ibrahim O
authors: IO
authors: Sayed-Ahmed
authors: Daniel P
authors: DP
authors: Warren
authors: George A
authors: GA
authors: Kounis
authors: Zachary
authors: Z
authors: Davis
authors: Florence
authors: F
authors: Cabot
authors: Sonia H
authors: SH
authors: Yoo
authors: Terrence P
authors: TP
authors: O'Brien
authors: Kendall E
authors: KE
authors: Donaldson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction / Q000379:methods*; D005260:Female; D006801:Humans; D007498:Iris / Q000473:pathology*; D053685:Laser Therapy / Q000009:adverse effects* / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D015877:Miosis / Q000175:diagnosis / Q000209:etiology*; D057234:Preoperative Period; D011446:Prospective Studies; D011680:Pupil