title: Importance of Tight Junctions in Relation to Skin Barrier Function.
abstract: Tight junctions (TJs) are complex cell-cell junctions that form a barrier in the stratum granulosum of mammalian skin. Besides forming a barrier themselves, TJs influence other skin barriers, e.g. the stratum corneum barrier, and are influenced by other skin barriers, e.g. by the chemical, the microbiome, or the immunological barrier and likely by the basement membrane. This review summarizes the dynamic interaction of the TJ barrier with other barriers in the skin and the central role of TJs in skin barrier function.
authors: Department of Dermatology and Venerology, Laboratory for Cell and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
authors: Johanna M
authors: JM
authors: Brandner
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D057167:Claudins / Q000378:metabolism*; D004817:Epidermis / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D010539:Permeability; D012879:Skin Physiological Phenomena; D019108:Tight Junctions / Q000276:immunology / Q000382:microbiology / Q000502:physiology*; D062825:Zonula Occludens Proteins / Q000378:metabolism*
chemical_list: D023181:Antimicrobial Cationic Peptides; D057167:Claudins; D062825:Zonula Occludens Proteins