title: A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells.
abstract: Bioinformatics and computational modelling are expected to offer innovative approaches in human medical science. In the present study, we performed computational analyses and made predictions using transcriptome and metabolome datasets obtained from fluorescence-based visualisations of chemotherapy-resistant cancer stem cells (CSCs) in the human oesophagus. This approach revealed an uncharacterized role for the ornithine metabolic pathway in the survival of chemotherapy-resistant CSCs. The present study fastens this rationale for further characterisation that may lead to the discovery of innovative drugs against robust CSCs.
authors: Department of Cancer Profiling Discovery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
authors: Jun
authors: J
authors: Koseki
authors: Faculty of Mathematics, Kyushu University, Fukuoka, 819-0395, Japan.
authors: Hidetoshi
authors: H
authors: Matsui
authors: Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
authors: Masamitsu
authors: M
authors: Konno
authors: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
authors: Naohiro
authors: N
authors: Nishida
authors: Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.|Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
authors: Koichi
authors: K
authors: Kawamoto
authors: Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.|Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
authors: Yoshihiro
authors: Y
authors: Kano
authors: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
authors: Masaki
authors: M
authors: Mori
authors: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
authors: Yuichiro
authors: Y
authors: Doki
authors: Department of Cancer Profiling Discovery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.|Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
authors: Hideshi
authors: H
authors: Ishii
mesh_terms: D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D019295:Computational Biology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects / Q000235:genetics*; D004947:Esophagus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005472:Fluorouracil / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053858:Metabolic Networks and Pathways; D055442:Metabolome; D015233:Models, Statistical; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009952:Ornithine / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D011700:Putrescine / Q000378:metabolism; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D013097:Spermine Synthase / Q000235:genetics / Q000378:metabolism; D059467:Transcriptome; D000099228:Diamine N-Acetyltransferase
chemical_list: D000123:Acetyltransferases; D000964:Antimetabolites, Antineoplastic; D002945:Cisplatin; D005472:Fluorouracil; D009952:Ornithine; D011506:Proteins; D011700:Putrescine; D013095:Spermidine; D013096:Spermine; D013097:Spermine Synthase; D000099228:Diamine N-Acetyltransferase; C031017:ornithine decarboxylase antizyme