title: A Transient Translaminar GABAergic Interneuron Circuit Connects Thalamocortical Recipient Layers in Neonatal Somatosensory Cortex.
abstract: GABAergic activity is thought to influence developing neocortical sensory circuits. Yet the late postnatal maturation of local layer (L)4 circuits suggests alternate sources of GABAergic control in nascent thalamocortical networks. We show that a population of L5b, somatostatin (SST)-positive interneuron receives early thalamic synaptic input and, using laser-scanning photostimulation, identify an early transient circuit between these cells and L4 spiny stellates (SSNs) that disappears by the end of the L4 critical period. Sensory perturbation disrupts the transition to a local GABAergic circuit, suggesting a link between translaminar and local control of SSNs. Conditional silencing of SST+ interneurons or conversely biasing the circuit toward local inhibition by overexpression of neuregulin-1 type 1 results in an absence of early L5b GABAergic input in mutants and delayed thalamic innervation of SSNs. These data identify a role for L5b SST+ interneurons in the control of SSNs in the early postnatal neocortex.
authors: Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK.
authors: Andre
authors: A
authors: Marques-Smith
authors: Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK.
authors: Daniel
authors: D
authors: Lyngholm
authors: Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK.
authors: Anna-Kristin
authors: AK
authors: Kaufmann
authors: Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK.
authors: Jacqueline A
authors: JA
authors: Stacey
authors: Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK.
authors: Anna
authors: A
authors: Hoerder-Suabedissen
authors: Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK.
authors: Esther B E
authors: EB
authors: Becker
authors: Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
authors: Michael C
authors: MC
authors: Wilson
authors: Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK.
authors: Zoltán
authors: Z
authors: Molnár
authors: Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK. Electronic address: simon.butt@dpag.ox.ac.uk.
authors: Simon J B
authors: SJ
authors: Butt
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D005260:Female; D007395:Interneurons / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009434:Neural Pathways; D020890:Neuregulin-1 / Q000096:biosynthesis; D010775:Photic Stimulation; D013003:Somatosensory Cortex / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D013004:Somatostatin / Q000502:physiology; D013788:Thalamus / Q000166:cytology* / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D020890:Neuregulin-1; C490581:Nrg1 protein, mouse; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid