title: Intracranial spread of IgG4-related disease via skull base foramina.
abstract: IgG4-related disease (IgG4-RD) is a newly recognised, multiorgan, inflammatory disease, and its full clinical spectrum remains undefined. We present a biopsy-proven case of IgG4-RD presenting with a parapharyngeal mass with intracranial extension and possible involvement of the brain parenchyma. We highlight the importance of considering the diagnosis in those presenting with tumefactive lesions, leptomeningitis or pachymeningitis and emphasise the value of securing a tissue diagnosis so that appropriate long-term treatment can be instigated and complications avoided.
authors: Department of Neurology, North Bristol NHS Trust, Bristol, UK Clinical Neuroscience, School of Clinical Sciences, University of Bristol, Bristol, UK.
authors: C M
authors: CM
authors: Rice
authors: Department of Neurology, North Bristol NHS Trust, Bristol, UK.
authors: T
authors: T
authors: Spencer
authors: Department of Radiology, Sunderland Royal Hospital, Sunderland, UK.
authors: G
authors: G
authors: Bunea
authors: Department of Neurology, North Bristol NHS Trust, Bristol, UK Clinical Neuroscience, School of Clinical Sciences, University of Bristol, Bristol, UK.
authors: N J
authors: NJ
authors: Scolding
authors: Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors: P
authors: P
authors: Sloan
authors: Department of Neurology, Sunderland Royal Hospital, Sunderland, UK.
authors: U
authors: U
authors: Nath
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications*; D001706:Biopsy; D006801:Humans; D007074:Immunoglobulin G; D008297:Male; D008581:Meningitis; D008875:Middle Aged; D019291:Skull Base / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G
keywords: IgG4-related disease; NEUROIMMUNOLOGY; dacryosialoadenopathy; leptomeningitis; pachymeningitis