title: Cardiac structure and function, and ventricular-arterial interaction 11 years following a pregnancy with preeclampsia.
abstract: Preeclampsia (PE) is associated with acute left ventricular dysfunction. Whether these changes eventually resolve remains unclear. This study assessed left and right ventricular structure and function, and ventricular-arterial interaction in 15 women 11 years after a pregnancy with PE and 16 matched control subjects with a normal pregnancy. We found normal left and right ventricular dimensions, systolic function, and global left ventricular strain, with no differences between the groups. In addition, indices of diastolic function, left and right atrial size, and amino-terminal pro-brain natriuretic peptide were normal and did not differ between the groups. Women with a previous PE had impaired night/day ratios for systolic and diastolic ambulatory blood pressure. However, indices of aortic stiffness or ventricular-arterial coupling did not differ between the groups. In conclusion, we could not demonstrate remaining alterations in systolic or diastolic left or right ventricular function, or in ventricular-arterial interaction in women 11 years after PE.
authors: Department of Women's and Children's Health, Division of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden.
authors: Maha
authors: M
authors: Al-Nashi
authors: Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
authors: Maria J
authors: MJ
authors: Eriksson
authors: Department of Clinical Science and Education South General Hospital, Division of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden.
authors: Eva
authors: E
authors: Östlund
authors: Department of Women's and Children's Health, Division of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden.
authors: Katarina
authors: K
authors: Bremme
authors: Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: thomas.kahan@ds.se.
authors: Thomas
authors: T
authors: Kahan
mesh_terms: D000328:Adult; D016275:Atrial Function; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D016022:Case-Control Studies; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D013599:Systole / Q000502:physiology; D059289:Vascular Stiffness; D018487:Ventricular Dysfunction, Left / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D016276:Ventricular Function
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Diastolic function; echocardiography; preeclampsia; systolic function; ventricular-arterial coupling