title: Treatment of Scabies: Comparison of Lindane 1% vs Permethrin 5.
abstract: Scabies, whose etiologic agent is Sarcoptes scabiei, is a neglected parasitic disease that is a major public health problem in many resourcepoor regions. Its current therapies include benzyl benzoate, lindane, permethrin, sulfur, crotamiton, monosulfiram, and oral ivermectin. The aim of this study was to compare the efficacy and safety of lindane 1% lotion vs permethrin 5% in the treatment of scabies. A total of 120 patients with scabies attending a dermatology outpatient department were included. Patients were randomly divided into two groups. Sixty patients and their family contacts received 5% permethrin cream and the other 60 received 1% lindane lotion. Treatment was evaluated at intervals of 2 and 4 weeks. Permethrin provided improvement in 48 patients (80%) after 2 weeks, whereas lindane was effective in only 28 patients (46.6%). Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies compared with lindane in this study. Adverse effects were rare in both the permethrin and lindane groups.
authors: Department of Medicinal Chemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Elham
authors: E
authors: Rezaee
authors: Department of Dermatology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Mohamad
authors: M
authors: Goldust
authors: Department of Dermatology, Tabriz University of Medical Sciences, Tabriz, Iran; alipour_homan@yahoo.com.
authors: Houman
authors: H
authors: Alipour
mesh_terms: D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D001556:Hexachlorocyclohexane / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007306:Insecticides / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D026023:Permethrin / Q000008:administration & dosage* / Q000009:adverse effects; D012532:Scabies / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007306:Insecticides; D026023:Permethrin; D001556:Hexachlorocyclohexane