title: Simultaneous and sequential hemorrhage of multiple cerebral cavernous malformations: a case report.
abstract: BACKGROUND
  The etiology of cerebral cavernous malformation hemorrhage is not well understood. Causative physiologic parameters preceding hemorrhagic cavernous malformation events are often not reported. We present a case of an individual with sequential simultaneous hemorrhages in multiple cerebral cavernous malformations with a new onset diagnosis of hypertension.
  
  
  METHODS
  A 42-year-old white man was admitted to our facility with worsening headache, left facial and tongue numbness, dizziness, diplopia, and elevated blood pressure. His past medical history was significant for new onset diagnosis of hypertension and chronic seasonal allergies. Serial imaging over the ensuing 8 days revealed sequential hemorrhagic lesions. He underwent suboccipital craniotomy for resection of the lesions located in the fourth ventricle and right cerebellum. One month after surgery, he had near complete resolution of his symptoms with mild residual vertigo but symptomatic chronic hypertension.
  
  
  CONCLUSIONS
  Many studies have focused on genetic and inflammatory mechanisms contributing to cerebral cavernous malformation rupture, but few have reported on the potential of hemodynamic changes contributing to cerebral cavernous malformation rupture. Systemic blood pressure changes clearly have an effect on angioma pressures. When considering the histopathological features of cerebral cavernous malformation architecture, changes in arterial pressure could cause meaningful alterations in hemorrhage propensity and patterns.
authors: Department of Neurosurgery, Cabell Huntington Hospital, Marshall University, 1600 Medical Center Drive, Huntington, WV, 25701, USA. aidnul@icloud.com.
authors: Nundia
authors: N
authors: Louis
authors: Department of Neurosurgery, Cabell Huntington Hospital, Marshall University, 1600 Medical Center Drive, Huntington, WV, 25701, USA. marshr@gmail.com.
authors: Robert
authors: R
authors: Marsh
mesh_terms: D000328:Adult; D016543:Central Nervous System Neoplasms / Q000150:complications* / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000209:etiology*; D003399:Craniotomy; D020786:Hemangioma, Cavernous, Central Nervous System / Q000150:complications* / Q000601:surgery; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male