title: Tissue-resident memory T cells in cytomegalovirus infection.
abstract: Herpesviruses establish life-long infection in their hosts and maintain latent reservoirs for sporadic reactivation at peripheral sites, such as skin and mucosae. For herpes simplex virus infection, experimental studies in mice revealed that immediate protection against local reactivation or superinfection events in the skin relies on tissue resident memory T cells (TRM) rather than on their circulating counterparts. Recent evidence extends this notion to cytomegalovirus infection, which potently induces TRM cells in both mice and humans particularly in mucosal tissues that constitute important viral sanctuaries and are relevant entry sites for challenge and superinfections. The discovery unravels promising opportunities to exploit cytomegalovirus based vaccine vectors for the specific induction of tissue resident T cell subsets.
authors: Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.
authors: Jenny Tosca
authors: JT
authors: Thom
authors: Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: oxenius@micro.biol.ethz.ch.
authors: Annette
authors: A
authors: Oxenius
mesh_terms: D000818:Animals; D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000517:prevention & control / Q000821:virology*; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D009092:Mucous Membrane / Q000276:immunology / Q000473:pathology / Q000821:virology; D009928:Organ Specificity / Q000276:immunology; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D014765:Viral Vaccines / Q000276:immunology; D014775:Virus Activation / Q000276:immunology; D014779:Virus Replication
chemical_list: D014765:Viral Vaccines