title: The PTEN protein: cellular localization and post-translational regulation.
abstract: The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the growth and proliferation of many cell types. It has been heavily studied, in large part due to its status as a tumour suppressor, the loss of function of which is observed through diverse mechanisms in many tumour types. Here we present a concise review of our understanding of the PTEN protein and highlight recent advances, particularly in our understanding of its localization and regulation by ubiquitination and SUMOylation.
authors: Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh EH14 4AS, U.K. n.r.leslie@hw.ac.uk.
authors: Nick R
authors: NR
authors: Leslie
authors: Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh EH14 4AS, U.K.
authors: Nisha
authors: N
authors: Kriplani
authors: Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh EH14 4AS, U.K.
authors: Miguel A
authors: MA
authors: Hermida
authors: Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh EH14 4AS, U.K.
authors: Virginia
authors: V
authors: Alvarez-Garcia
authors: Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh EH14 4AS, U.K.
authors: Helen M
authors: HM
authors: Wise
mesh_terms: D002477:Cells / Q000201:enzymology*; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D025841:Small Ubiquitin-Related Modifier Proteins; D025801:Ubiquitin; D051059:PTEN Phosphohydrolase
keywords: AKT; cancer; phosphatase; phosphoinositide 3-kinase; signal transduction; ubiquitin